## Fri Jan 3 07:04:59 2025 ## emapper-2.1.12 ## /data/home/zhuyingjie/miniforge3/envs/eggnog/bin/emapper.py -i /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/mmseqs_cluster/PRJNA858966/SRR20218967/SRR20218967_p_cluster_rep_seq.fasta --output PRJNA858966_SRR20218967 --data_dir /data/software/eggnog_database -m diamond --sensmode fast --output_dir /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/annotation --temp_dir /data/software/eggnog_database/temp --excel --dbmem --cpu 24 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs k59_1153791_1 945713.IALB_1901 5.33e-77 260.0 COG4590@1|root,COG4590@2|Bacteria 2|Bacteria P Binding-protein-dependent transport system inner membrane component pstC - - ko:K02037,ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_996765_1 1144275.COCOR_06353 3.05e-94 296.0 COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria 1224|Proteobacteria G Glycoside Hydrolase - - - - - - - - - - - - Glyco_hydro_15 k59_632674_1 583355.Caka_2195 1.18e-100 306.0 COG3119@1|root,COG3119@2|Bacteria 2|Bacteria P arylsulfatase activity aslA - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_1101771_1 509190.Cseg_2097 7.8e-06 48.9 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2U0JP@28211|Alphaproteobacteria,2KJZI@204458|Caulobacterales 204458|Caulobacterales K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_1049462_1 1185876.BN8_02342 6.36e-43 159.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,4NFKH@976|Bacteroidetes,47JB7@768503|Cytophagia 976|Bacteroidetes E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_789276_1 1298858.AUEL01000019_gene3199 3.56e-41 149.0 COG4671@1|root,COG4671@2|Bacteria,1NE6T@1224|Proteobacteria,2U08G@28211|Alphaproteobacteria,43GQW@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Glycosyltransferase family 28 C-terminal domain redA - - - - - - - - - - - Glyco_tran_28_C k59_1049463_1 1317124.DW2_03204 9.9e-62 202.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2TUHU@28211|Alphaproteobacteria,2XNZF@285107|Thioclava 28211|Alphaproteobacteria E Peptidase dimerisation domain - - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_944540_1 1123400.KB904754_gene1029 1.2e-20 94.4 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,460EA@72273|Thiotrichales 72273|Thiotrichales F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_789281_1 246195.DNO_0634 4.57e-37 134.0 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,1S8R3@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) ltg - - - - - - - - - - - DUF4124,SLT k59_840504_1 305700.B447_12082 8.74e-62 200.0 COG0491@1|root,COG0491@2|Bacteria,1NCIF@1224|Proteobacteria,2VJVR@28216|Betaproteobacteria,2KV3A@206389|Rhodocyclales 206389|Rhodocyclales S COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B k59_1207331_1 710421.Mycch_0546 3.98e-16 76.6 COG0451@1|root,COG0451@2|Bacteria,2HS3E@201174|Actinobacteria,23D32@1762|Mycobacteriaceae 201174|Actinobacteria GM NmrA-like family - - - - - - - - - - - - Epimerase,F420H2_quin_red k59_1207331_2 1172188.KB911826_gene105 6.41e-25 104.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4FF8I@85021|Intrasporangiaceae 201174|Actinobacteria Q Belongs to the cytochrome P450 family cyp20 - 1.14.14.1 ko:K00493 ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120 - R03629,R04121,R05259 RC00046,RC01311 ko00000,ko00001,ko01000 - - - p450 k59_370362_2 1280666.ATVS01000014_gene704 3.87e-46 162.0 COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,4BWEW@830|Butyrivibrio 186801|Clostridia S Protein of unknown function (DUF1015) - - - - - - - - - - - - DUF1015 k59_1362852_1 366602.Caul_1908 0.000711 48.1 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1259450_1 697282.Mettu_2798 1.96e-35 130.0 COG1411@1|root,COG1411@2|Bacteria,1RHWE@1224|Proteobacteria,1S8KI@1236|Gammaproteobacteria,1XF7T@135618|Methylococcales 135618|Methylococcales S Belongs to the HisA HisF family - - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_684813_1 187272.Mlg_1887 2.69e-71 218.0 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1WY2N@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_944548_1 1122603.ATVI01000006_gene42 1.8e-49 171.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1X31U@135614|Xanthomonadales 135614|Xanthomonadales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_944548_2 1335757.SPICUR_09505 8.29e-26 101.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1WY1N@135613|Chromatiales 135613|Chromatiales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_579275_1 626887.J057_23480 6.2e-91 285.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,4645B@72275|Alteromonadaceae 1236|Gammaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_58029_1 1283300.ATXB01000001_gene684 1.67e-17 79.0 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1XF1C@135618|Methylococcales 135618|Methylococcales H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_58029_2 1318628.MARLIPOL_14075 9.27e-72 228.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,464S8@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_00243,iECBD_1354.ECBD_3376,iECB_1328.ECB_00240,iECD_1391.ECD_00240,iYL1228.KPN_00280 Aldedh k59_1153821_1 1232683.ADIMK_2476 6.26e-49 165.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,464U7@72275|Alteromonadaceae 1236|Gammaproteobacteria S stress-induced protein yicC GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575 - - - - - - - - - - DUF1732,YicC_N k59_108732_1 754477.Q7C_2153 7.58e-81 253.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria,45ZW0@72273|Thiotrichales 72273|Thiotrichales F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_265956_1 316067.Geob_0994 5.16e-23 103.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42RS8@68525|delta/epsilon subdivisions,2WND0@28221|Deltaproteobacteria,43UCV@69541|Desulfuromonadales 28221|Deltaproteobacteria L PFAM RNA-directed DNA polymerase (Reverse transcriptase) - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - Cas_Cas1,GIIM,RVT_1 k59_944557_1 1382356.JQMP01000003_gene2043 3.17e-57 201.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2G5ZQ@200795|Chloroflexi,27XZV@189775|Thermomicrobia 189775|Thermomicrobia C FAD linked oxidases, C-terminal domain - - - - - - - - - - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17 k59_1571473_1 3711.Bra024288.1-P 5.15e-27 109.0 COG0288@1|root,KOG1578@2759|Eukaryota,37QZ9@33090|Viridiplantae,3G7Q6@35493|Streptophyta,3HNNB@3699|Brassicales 35493|Streptophyta P Reversible hydration of carbon dioxide - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_1571473_3 1304885.AUEY01000041_gene3693 9.31e-20 88.6 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,42MVM@68525|delta/epsilon subdivisions,2WJ4I@28221|Deltaproteobacteria,2MHWY@213118|Desulfobacterales 28221|Deltaproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535,ko:K13599 ko00540,ko01100,ko02020,map00540,map01100,map02020 M00060,M00498 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005,ko02022 - - - LpxC k59_840526_1 331869.BAL199_28235 6.94e-16 79.3 COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2TUT7@28211|Alphaproteobacteria,4BQQC@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Nitronate monooxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_58048_1 1144310.PMI07_005331 2.84e-37 133.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,4B8MV@82115|Rhizobiaceae 28211|Alphaproteobacteria E ABC-type polar amino acid transport system, ATPase component glnQ - 3.6.3.21 ko:K02028,ko:K09972 ko02010,map02010 M00232,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - ABC_tran k59_213620_1 983917.RGE_06490 6.58e-14 72.0 COG1024@1|root,COG1024@2|Bacteria,1RGAR@1224|Proteobacteria,2VSC3@28216|Betaproteobacteria 28216|Betaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_213620_2 1095769.CAHF01000013_gene3288 1.57e-33 125.0 COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2VNCV@28216|Betaproteobacteria,475IH@75682|Oxalobacteraceae 28216|Betaproteobacteria S Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_422637_1 243365.CV_0631 3.3e-39 149.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,2KU45@206351|Neisseriales 206351|Neisseriales P ABC transporter transmembrane region - - - ko:K06147,ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1153843_1 1415780.JPOG01000001_gene2897 4.31e-70 227.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,1X587@135614|Xanthomonadales 135614|Xanthomonadales S Succinylglutamate desuccinylase / Aspartoacylase family - - - - - - - - - - - - AstE_AspA k59_735967_2 1177179.A11A3_15147 3.67e-17 80.9 COG0454@1|root,COG0456@2|Bacteria,1N4JC@1224|Proteobacteria,1SDHV@1236|Gammaproteobacteria,1XMSM@135619|Oceanospirillales 135619|Oceanospirillales K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1 k59_1153844_1 1131269.AQVV01000021_gene2159 9.29e-83 265.0 COG1154@1|root,COG1154@2|Bacteria 2|Bacteria H 1-deoxy-D-xylulose-5-phosphate synthase activity dxs GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030145,GO:0030975,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0040007,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527 DXP_synthase_N,Transket_pyr,Transketolase_C k59_422638_1 565045.NOR51B_372 1.4e-15 76.6 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the NadC ModD family nadC GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_0109 QRPTase_C,QRPTase_N k59_422638_2 314278.NB231_08745 2.07e-51 165.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1S617@1236|Gammaproteobacteria,1X1IW@135613|Chromatiales 135613|Chromatiales O FKBP-type peptidyl-prolyl cis-trans - - - - - - - - - - - - FKBP_C k59_422638_3 396588.Tgr7_0799 2.29e-21 93.2 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,1WXAG@135613|Chromatiales 135613|Chromatiales E PFAM sodium alanine symporter - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_1467661_1 482537.XP_008568807.1 3.52e-15 75.5 COG0045@1|root,KOG1447@2759|Eukaryota,3AFKM@33154|Opisthokonta,3BHY2@33208|Metazoa,3CWAC@33213|Bilateria,486K1@7711|Chordata,494BP@7742|Vertebrata,3J200@40674|Mammalia,35J3G@314146|Euarchontoglires 33208|Metazoa C GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit SUCLG2 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0004777,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006104,GO:0006105,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016620,GO:0016874,GO:0016877,GO:0016878,GO:0016903,GO:0016999,GO:0017076,GO:0017144,GO:0019001,GO:0019003,GO:0019637,GO:0019693,GO:0019752,GO:0030062,GO:0031974,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0036094,GO:0042709,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045244,GO:0045333,GO:0046483,GO:0046982,GO:0046983,GO:0051186,GO:0055086,GO:0055114,GO:0070013,GO:0071704,GO:0071944,GO:0072350,GO:0072521,GO:0097159,GO:0097367,GO:0098798,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902494 6.2.1.4,6.2.1.5 ko:K01900 ko00020,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011 R00432,R00727 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ATP-grasp_2,Ligase_CoA k59_892930_2 641147.HMPREF9021_00869 0.000546 42.7 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2VINM@28216|Betaproteobacteria,2KPEU@206351|Neisseriales 206351|Neisseriales M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_789333_1 391625.PPSIR1_31323 1.26e-95 300.0 COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,42NBI@68525|delta/epsilon subdivisions,2WM33@28221|Deltaproteobacteria,2YUS1@29|Myxococcales 28221|Deltaproteobacteria T Carbon starvation protein cstA - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM k59_1101823_1 1120792.JAFV01000001_gene2103 0.000406 44.7 COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2UBYM@28211|Alphaproteobacteria,36YIH@31993|Methylocystaceae 28211|Alphaproteobacteria S Thioesterase-like superfamily ybgC - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT k59_1101823_2 981336.F944_00327 4.33e-08 55.8 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,3NK2Q@468|Moraxellaceae 1236|Gammaproteobacteria U MotA/TolQ/ExbB proton channel family tolQ GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0017038,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0033036,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_474698_1 235985.BBPN01000012_gene6842 1.15e-24 108.0 COG0421@1|root,COG0421@2|Bacteria 2|Bacteria E spermidine synthase activity - - - - - - - - - - - - Spermine_synth k59_632746_1 768679.TTX_1787 7.19e-49 173.0 COG1012@1|root,arCOG01252@2157|Archaea,2XRM8@28889|Crenarchaeota 28889|Crenarchaeota C Aldehyde dehydrogenase family - - 1.2.1.88 ko:K00294 ko00250,ko00330,ko01100,map00250,map00330,map01100 - R00245,R00707,R00708,R04444,R04445,R05051 RC00080,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000 - - - Aldedh k59_944585_1 765911.Thivi_2221 2.14e-91 282.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1WWNX@135613|Chromatiales 135613|Chromatiales E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_422658_1 335543.Sfum_2243 4.23e-78 240.0 COG1216@1|root,COG1216@2|Bacteria,1R50T@1224|Proteobacteria,42P74@68525|delta/epsilon subdivisions,2WK88@28221|Deltaproteobacteria,2MQ8C@213462|Syntrophobacterales 28221|Deltaproteobacteria S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2,Methyltransf_23 k59_632768_1 1408424.JHYI01000058_gene1560 6.22e-63 208.0 COG3547@1|root,COG3547@2|Bacteria,1V427@1239|Firmicutes,4HGY6@91061|Bacilli,1ZERT@1386|Bacillus 91061|Bacilli L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_579331_1 1163617.SCD_n02328 3.22e-45 150.0 COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,2VSE7@28216|Betaproteobacteria 28216|Betaproteobacteria J chain release factor yaeJ - - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 k59_579331_2 1348657.M622_02600 3.05e-21 87.0 COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,2VSZE@28216|Betaproteobacteria,2KWRE@206389|Rhodocyclales 206389|Rhodocyclales L HNH nucleases - - - - - - - - - - - - HNH k59_944602_1 671143.DAMO_2812 7.75e-88 270.0 COG0372@1|root,COG0372@2|Bacteria,2NP9P@2323|unclassified Bacteria 2|Bacteria C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_1101849_1 391615.ABSJ01000054_gene1458 7.79e-36 135.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1J5D0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KL HELICc2 yoaA GO:0003674,GO:0003824,GO:0004386,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:1901360 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,ResIII k59_1101849_2 1500893.JQNB01000001_gene150 1.97e-43 160.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1X3ZE@135614|Xanthomonadales 135614|Xanthomonadales KL Helicase yoaA - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,Helicase_C_2,ResIII k59_475423_2 795797.C497_07869 1.37e-14 75.5 COG0530@1|root,arCOG02881@2157|Archaea,2XTN0@28890|Euryarchaeota,23TQ3@183963|Halobacteria 183963|Halobacteria P COG0530 Ca2 Na antiporter - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_1624691_1 1121459.AQXE01000003_gene1104 2.08e-17 85.5 COG1253@1|root,COG1253@2|Bacteria,1MWT3@1224|Proteobacteria,42N45@68525|delta/epsilon subdivisions,2WKUD@28221|Deltaproteobacteria,2M8FS@213115|Desulfovibrionales 28221|Deltaproteobacteria S CBS domain containing protein - - - - - - - - - - - - CBS,DUF21 k59_841202_1 266834.SM_b21477 1.05e-40 153.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U1Z0@28211|Alphaproteobacteria,4BBMN@82115|Rhizobiaceae 28211|Alphaproteobacteria L reverse transcriptase - - - ko:K15342 - - - - ko00000,ko02048,ko03400 - - - Cas_Cas1,GIIM,RVT_1 k59_527580_1 472759.Nhal_3811 9.14e-24 95.1 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria,1WY0E@135613|Chromatiales 135613|Chromatiales F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_527580_2 1328313.DS2_06581 4.96e-20 86.3 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria,4677N@72275|Alteromonadaceae 1236|Gammaproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate tsaC GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061710,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC k59_945263_1 1121472.AQWN01000002_gene2301 3.44e-61 212.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,2605R@186807|Peptococcaceae 186801|Clostridia L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_371085_1 1232410.KI421424_gene1751 9.99e-65 211.0 COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,42NS9@68525|delta/epsilon subdivisions,2WJMJ@28221|Deltaproteobacteria,43SCR@69541|Desulfuromonadales 28221|Deltaproteobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_109462_1 517418.Ctha_0472 2.91e-14 71.6 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1FEF9@1090|Chlorobi 1090|Chlorobi C electron transfer flavoprotein-ubiquinone oxidoreductase - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO k59_109462_3 264462.Bd1016 1.68e-20 90.1 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,42UYD@68525|delta/epsilon subdivisions,2MUPZ@213481|Bdellovibrionales,2WR5I@28221|Deltaproteobacteria 213481|Bdellovibrionales P Plays a role in the regulation of phosphate uptake - - - ko:K02039 - - - - ko00000 - - - PhoU k59_266711_1 1056512.D515_02896 3.98e-18 84.7 COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,1S682@1236|Gammaproteobacteria,1XSNS@135623|Vibrionales 135623|Vibrionales S protein conserved in bacteria TLL0138 - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_1518556_1 1501230.ET33_00550 2.91e-62 204.0 COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,4HBXF@91061|Bacilli,26SEN@186822|Paenibacillaceae 91061|Bacilli M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_1518556_2 251221.35214275 5.63e-68 212.0 COG1898@1|root,COG1898@2|Bacteria,1G0QA@1117|Cyanobacteria 1117|Cyanobacteria G Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_1311205_2 1333998.M2A_0668 2.06e-26 100.0 COG1545@1|root,COG1545@2|Bacteria,1RFF1@1224|Proteobacteria,2UTI3@28211|Alphaproteobacteria 28211|Alphaproteobacteria S DUF35 OB-fold domain, acyl-CoA-associated - - - - - - - - - - - - DUF35_N,OB_aCoA_assoc k59_997625_1 909663.KI867150_gene1564 6.43e-65 221.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2MQ92@213462|Syntrophobacterales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K01338,ko:K04076 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Lon_C,Mg_chelatase k59_1624718_1 1463887.KL590035_gene7057 1.06e-20 95.9 COG1216@1|root,COG1216@2|Bacteria,2GKTW@201174|Actinobacteria 201174|Actinobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glyco_transf_7C,Glycos_transf_2 k59_736676_1 1535422.ND16A_3185 1.59e-72 246.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q7E9@267889|Colwelliaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_371103_1 468059.AUHA01000002_gene563 2.22e-16 84.7 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IR3J@117747|Sphingobacteriia 976|Bacteroidetes K Tetratricopeptide repeat - - - - - - - - - - - - ANAPC3,Guanylate_cyc,HTH_18,TPR_8 k59_427525_1 519989.ECTPHS_07242 8.12e-92 285.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales 135613|Chromatiales K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_1521295_1 269799.Gmet_1849 3.75e-34 133.0 COG1192@1|root,COG1192@2|Bacteria,1NPCB@1224|Proteobacteria,42Y7J@68525|delta/epsilon subdivisions,2WUHN@28221|Deltaproteobacteria,43T7Q@69541|Desulfuromonadales 28221|Deltaproteobacteria D NUBPL iron-transfer P-loop NTPase - - - - - - - - - - - - AAA_31 k59_1521295_2 999141.GME_03842 2.76e-25 102.0 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,1XIE8@135619|Oceanospirillales 135619|Oceanospirillales M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_218560_2 314278.NB231_17408 6.64e-38 145.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) - - 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_690501_1 1996.JOFO01000013_gene3361 7.28e-101 313.0 COG0318@1|root,COG0318@2|Bacteria,2GMVB@201174|Actinobacteria,4EGSF@85012|Streptosporangiales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_480099_1 243365.CV_3686 4.45e-50 171.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria,2KPBZ@206351|Neisseriales 206351|Neisseriales BQ histone deacetylase hda - - - - - - - - - - - Hist_deacetyl k59_1001452_1 330214.NIDE3947 3.48e-77 247.0 COG0668@1|root,COG0668@2|Bacteria 2|Bacteria M transmembrane transport mscM - - - - - - - - - - - MS_channel k59_639053_1 349124.Hhal_1035 3.73e-87 277.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1WWGK@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase, dimerisation - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_1106786_1 1192034.CAP_5616 1.57e-25 108.0 COG2866@1|root,COG2866@2|Bacteria,1R586@1224|Proteobacteria,433ZT@68525|delta/epsilon subdivisions,2X4AT@28221|Deltaproteobacteria,2YYMP@29|Myxococcales 28221|Deltaproteobacteria E Zn_pept - - - - - - - - - - - - Peptidase_M14 k59_584025_1 402881.Plav_0163 5.36e-58 197.0 28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,2U2TN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_480102_1 502025.Hoch_4987 1.55e-43 159.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2YU3Z@29|Myxococcales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-2 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_480102_2 1473546.CH76_03170 1.75e-21 94.0 COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,4H9U4@91061|Bacilli,3IW42@400634|Lysinibacillus 91061|Bacilli O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_1576154_1 177437.HRM2_36780 8.57e-65 213.0 COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria 1224|Proteobacteria K iron dependent repressor - - - - - - - - - - - - - k59_1265799_1 1111732.AZOD01000013_gene1991 6.72e-17 85.1 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1X3DY@135614|Xanthomonadales 135614|Xanthomonadales C NADH-quinone oxidoreductase nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_323675_1 1255043.TVNIR_1362 5.57e-110 335.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria,1WW7Z@135613|Chromatiales 135613|Chromatiales J TIGRFAM glutaminyl-tRNA synthetase glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_427540_1 1122915.AUGY01000035_gene1073 1.23e-18 87.8 COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,4HC6W@91061|Bacilli,26RIU@186822|Paenibacillaceae 91061|Bacilli J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS k59_427540_2 266117.Rxyl_1636 9.34e-15 74.3 COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4CPCY@84995|Rubrobacteria 84995|Rubrobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_113398_1 1163617.SCD_n00476 6.84e-20 87.8 COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,2VIG6@28216|Betaproteobacteria 28216|Betaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_113398_2 1255043.TVNIR_0863 9.75e-19 78.6 2E3CD@1|root,32YBP@2|Bacteria,1N8PD@1224|Proteobacteria,1SCSK@1236|Gammaproteobacteria,1WZ7C@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_113398_3 1266914.ATUK01000012_gene202 7.88e-38 135.0 2CARE@1|root,2Z8Q5@2|Bacteria,1R7S8@1224|Proteobacteria,1RRAH@1236|Gammaproteobacteria,1WW2H@135613|Chromatiales 135613|Chromatiales S TIGRFAM CRISPR-associated protein - - - - - - - - - - - - Cas6 k59_1576160_1 675806.VII_003361 1.4e-42 152.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1XSJM@135623|Vibrionales 135623|Vibrionales M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008784,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_1001468_1 1120959.ATXF01000010_gene180 1.54e-13 75.9 COG1322@1|root,COG1322@2|Bacteria,2HSYS@201174|Actinobacteria,4FQYM@85023|Microbacteriaceae 201174|Actinobacteria S RmuC family - - - - - - - - - - - - RmuC k59_1367774_1 1192034.CAP_7597 3.36e-19 88.2 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2YU9B@29|Myxococcales 28221|Deltaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_375482_1 1121878.AUGL01000007_gene1190 7.57e-55 179.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0000287,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019899,GO:0022613,GO:0032296,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_795955_1 1379270.AUXF01000001_gene2303 3.58e-22 101.0 COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,1ZUB1@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative glutamine amidotransferase - - - - - - - - - - - - GATase1_like k59_64540_1 215803.DB30_1616 5.99e-97 301.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2YU6B@29|Myxococcales 28221|Deltaproteobacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_64540_2 631454.N177_1277 8.25e-34 124.0 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2U5V2@28211|Alphaproteobacteria,1JP2U@119043|Rhodobiaceae 28211|Alphaproteobacteria O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_1265818_1 930169.B5T_00591 3.08e-52 174.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,1XHZW@135619|Oceanospirillales 135619|Oceanospirillales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_1265818_2 1125863.JAFN01000001_gene1718 4.31e-27 105.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,42NRX@68525|delta/epsilon subdivisions,2WK1K@28221|Deltaproteobacteria 28221|Deltaproteobacteria E TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0388 His_biosynth k59_897848_1 396588.Tgr7_0522 1.09e-73 232.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1WXFU@135613|Chromatiales 135613|Chromatiales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_480133_1 279010.BL03013 1.62e-108 324.0 COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,4HAP6@91061|Bacilli,1ZE4V@1386|Bacillus 91061|Bacilli C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit acoB - - ko:K21417 - - - - ko00000,ko01000 - - - Transket_pyr,Transketolase_C k59_1158330_1 1121403.AUCV01000026_gene2322 1.02e-105 324.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2WJ2N@28221|Deltaproteobacteria,2MI0Z@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_1265833_1 1380355.JNIJ01000050_gene134 4.25e-33 128.0 2BSZ4@1|root,32N30@2|Bacteria,1NTM8@1224|Proteobacteria,2UNVX@28211|Alphaproteobacteria,3K2SH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_480147_1 83406.HDN1F_27420 7.37e-54 181.0 COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,1RPZN@1236|Gammaproteobacteria,1J4S3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S FMN-dependent dehydrogenase - - 1.13.12.16,1.3.1.9 ko:K00459,ko:K02371 ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212 M00083 R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076,RC02541,RC02759 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO k59_1420256_1 449447.MAE_36130 4.81e-55 196.0 COG0841@1|root,COG0841@2|Bacteria,1G0C2@1117|Cyanobacteria 1117|Cyanobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_740753_1 1267535.KB906767_gene3554 4.69e-90 272.0 COG0074@1|root,COG0074@2|Bacteria,3Y3UX@57723|Acidobacteria,2JHSN@204432|Acidobacteriia 204432|Acidobacteriia C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_1001503_1 222534.KB893746_gene2703 5.59e-76 243.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria 201174|Actinobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_375514_1 436308.Nmar_0026 1.24e-50 169.0 COG1028@1|root,arCOG01259@2157|Archaea,41SXY@651137|Thaumarchaeota 651137|Thaumarchaeota I Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1054509_1 697282.Mettu_1569 3.17e-52 168.0 COG2905@1|root,COG2905@2|Bacteria,1MZGY@1224|Proteobacteria,1S86K@1236|Gammaproteobacteria,1XF65@135618|Methylococcales 135618|Methylococcales T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_1054509_2 207954.MED92_02274 1.37e-51 165.0 COG0347@1|root,COG0347@2|Bacteria,1RI28@1224|Proteobacteria,1S62Z@1236|Gammaproteobacteria,1XK6I@135619|Oceanospirillales 135619|Oceanospirillales K Nitrogen regulatory protein P-II - - - - - - - - - - - - - k59_1054509_3 754436.JCM19237_173 3.65e-51 169.0 arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,1RMI8@1236|Gammaproteobacteria,1XUA3@135623|Vibrionales 135623|Vibrionales S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_845460_1 875328.JDM601_1950 2.17e-53 178.0 COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,23456@1762|Mycobacteriaceae 201174|Actinobacteria S alcohol dehydrogenase adhA - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1576198_1 436308.Nmar_0063 6.85e-136 397.0 COG0423@1|root,arCOG00405@2157|Archaea,41S8S@651137|Thaumarchaeota 651137|Thaumarchaeota J synthetase (class II) - - 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b k59_1265841_1 1123355.JHYO01000002_gene1309 8.98e-15 80.1 COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,2UHNB@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins tonB_2 - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_691514_2 1123058.KB894219_gene166 2.51e-09 58.2 2CC49@1|root,33MRB@2|Bacteria,4P8SJ@976|Bacteroidetes 976|Bacteroidetes S Protein of unknown function (DUF1367) - - - - - - - - - - - - DUF1367 k59_428568_1 1195246.AGRI_12781 3.14e-33 135.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,4645Y@72275|Alteromonadaceae 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF,GAF_2,GGDEF,MASE3,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1159224_1 1111732.AZOD01000010_gene1041 4.93e-13 69.3 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1X3ZE@135614|Xanthomonadales 135614|Xanthomonadales KL Helicase yoaA - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,Helicase_C_2,ResIII k59_1159224_2 1122134.KB893650_gene940 2.06e-46 162.0 COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,1XH93@135619|Oceanospirillales 135619|Oceanospirillales J Elongation factor P--(R)-beta-lysine ligase genX - - ko:K04568 - - - - ko00000,ko01000,ko03012 - - - tRNA-synt_2 k59_1316009_1 331869.BAL199_21754 2.6e-76 237.0 COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TU63@28211|Alphaproteobacteria,4BSNZ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_846447_2 1265310.CCBD010000059_gene1324 1.01e-52 171.0 2F5RB@1|root,31WQN@2|Bacteria,2I9IG@201174|Actinobacteria,238AF@1762|Mycobacteriaceae 201174|Actinobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 k59_1630236_1 944479.JQLX01000012_gene1173 1.28e-18 84.7 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,42M7Y@68525|delta/epsilon subdivisions,2WIRN@28221|Deltaproteobacteria,2M6G5@213113|Desulfurellales 28221|Deltaproteobacteria E Argininosuccinate lyase C-terminal argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1,NUDIX k59_1630236_2 880072.Desac_2314 1.47e-51 172.0 COG1280@1|root,COG1280@2|Bacteria,1RJBR@1224|Proteobacteria,42T9G@68525|delta/epsilon subdivisions,2WP76@28221|Deltaproteobacteria,2MRPY@213462|Syntrophobacterales 28221|Deltaproteobacteria E LysE type translocator - - - - - - - - - - - - LysE k59_1421561_1 555079.Toce_0365 3.02e-14 75.9 COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia,42GCS@68295|Thermoanaerobacterales 186801|Clostridia G PFAM class II aldolase adducin family protein - - 4.1.2.17,5.1.3.4 ko:K01628,ko:K03077 ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120 M00550 R02262,R05850 RC00603,RC00604,RC01479 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II k59_797406_1 983545.Glaag_4154 6.65e-71 231.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,465RZ@72275|Alteromonadaceae 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1316017_1 204669.Acid345_1900 8.65e-76 249.0 COG2936@1|root,COG2936@2|Bacteria,3Y6W3@57723|Acidobacteria 57723|Acidobacteria S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_4945_1 557598.LHK_02092 3.63e-05 45.1 COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2VR8D@28216|Betaproteobacteria 28216|Betaproteobacteria CO Periplasmic protein thiol ccmG - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA,Redoxin k59_4945_2 768671.ThimaDRAFT_3410 3.79e-42 144.0 COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,1S9DV@1236|Gammaproteobacteria,1WY4S@135613|Chromatiales 135613|Chromatiales P subunit of a heme lyase - - - ko:K02200 - - - - ko00000 - - - CcmH k59_898901_1 331869.BAL199_27646 3.47e-08 57.4 COG0340@1|root,COG0340@2|Bacteria,1N1WU@1224|Proteobacteria,2TQK4@28211|Alphaproteobacteria 28211|Alphaproteobacteria H COG0340 Biotin-(acetyl-CoA carboxylase) ligase - - - - - - - - - - - - BPL_LplA_LipB_2,DUF4444 k59_585113_1 1517681.HW45_09505 1.49e-70 221.0 COG1794@1|root,COG1794@2|Bacteria,1MV03@1224|Proteobacteria,1RMHT@1236|Gammaproteobacteria,1XSX2@135623|Vibrionales 135623|Vibrionales M Aspartate racemase - - 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race k59_376583_1 582515.KR51_00002240 2.49e-27 106.0 COG0500@1|root,COG2226@2|Bacteria,1G1WF@1117|Cyanobacteria 1117|Cyanobacteria Q Methylase involved in ubiquinone menaquinone biosynthesis - - - - - - - - - - - - Methyltransf_25,Ubie_methyltran k59_1577184_1 1229909.NSED_02640 3.18e-101 295.0 COG1522@1|root,arCOG01580@2157|Archaea 1229909.NSED_02640|- K COG1522 Transcriptional regulators - - - - - - - - - - - - - k59_691547_2 1380356.JNIK01000015_gene2622 9.01e-09 58.2 COG0584@1|root,COG0584@2|Bacteria,2GJ5W@201174|Actinobacteria,4ESIX@85013|Frankiales 201174|Actinobacteria C glycerophosphoryl diester phosphodiesterase glpQ2 - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_1214613_1 330214.NIDE1528 3.18e-32 122.0 COG1716@1|root,COG1716@2|Bacteria 2|Bacteria T histone H2A K63-linked ubiquitination - - - - - - - - - - - - DUF4388,FHA,Yop-YscD_cpl k59_1055559_1 84531.JMTZ01000032_gene311 2.42e-27 111.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1X3I7@135614|Xanthomonadales 135614|Xanthomonadales S peptidoglycan-binding protein, lysm - - - - - - - - - - - - LysM k59_1055559_2 754477.Q7C_1939 3.93e-06 47.4 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,460SD@72273|Thiotrichales 72273|Thiotrichales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_1107839_1 933262.AXAM01000043_gene1184 3.9e-19 89.0 COG0177@1|root,COG0177@2|Bacteria,1RAK3@1224|Proteobacteria,42M4V@68525|delta/epsilon subdivisions,2WPRX@28221|Deltaproteobacteria,2MJJR@213118|Desulfobacterales 28221|Deltaproteobacteria L Protein of unknown function (DUF2400) - - - - - - - - - - - - DUF2400 k59_898915_1 342113.DM82_646 1.1e-91 274.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,1K20D@119060|Burkholderiaceae 28216|Betaproteobacteria O Belongs to the GST superfamily gstI - 2.5.1.18 ko:K00799,ko:K11209 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N,GST_N_2 k59_1214621_1 1144325.PMI22_04378 3.04e-19 90.5 COG0477@1|root,COG2814@2|Bacteria,1MXKN@1224|Proteobacteria,1S1A0@1236|Gammaproteobacteria 1236|Gammaproteobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_1107843_1 999419.HMPREF1077_00773 2.41e-50 173.0 COG0673@1|root,COG0673@2|Bacteria,4NGGS@976|Bacteroidetes,2FTQH@200643|Bacteroidia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_376596_1 671143.DAMO_0040 1.23e-54 186.0 COG0577@1|root,COG0577@2|Bacteria,2NQJU@2323|unclassified Bacteria 2|Bacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1421601_1 330214.NIDE3443 4.2e-116 347.0 COG0111@1|root,COG4747@1|root,COG0111@2|Bacteria,COG4747@2|Bacteria,3J0DZ@40117|Nitrospirae 40117|Nitrospirae E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_1522000_1 335543.Sfum_2205 1.74e-59 195.0 COG0715@1|root,COG0715@2|Bacteria,1MXA3@1224|Proteobacteria,42PS8@68525|delta/epsilon subdivisions,2WKAJ@28221|Deltaproteobacteria,2MRFQ@213462|Syntrophobacterales 28221|Deltaproteobacteria P NMT1/THI5 like - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1 k59_532819_1 330214.NIDE1429 1.1e-82 256.0 COG0265@1|root,COG0265@2|Bacteria 2|Bacteria O serine-type endopeptidase activity - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_428621_1 330214.NIDE0811 8.28e-11 61.2 COG0685@1|root,COG0685@2|Bacteria,3J0I8@40117|Nitrospirae 40117|Nitrospirae C Methylenetetrahydrofolate reductase - - - - - - - - - - - - MTHFR k59_428621_2 330214.NIDE0810 4.3e-109 319.0 COG0190@1|root,COG0190@2|Bacteria,3J0FT@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_585136_1 1504981.KO116_1614 1.11e-38 136.0 COG2010@1|root,COG2010@2|Bacteria,1MW1W@1224|Proteobacteria,1S1DG@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG2010 Cytochrome c, mono- and diheme variants - - - - - - - - - - - - Cytochrome_CBB3,DUF4440 k59_65877_1 279714.FuraDRAFT_3837 9.03e-97 314.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,2KQ3P@206351|Neisseriales 206351|Neisseriales M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_1107853_1 1458275.AZ34_04075 2.76e-82 258.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2VIDR@28216|Betaproteobacteria,4AAKQ@80864|Comamonadaceae 28216|Betaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_646017_1 1267533.KB906735_gene4585 1.06e-97 301.0 COG1053@1|root,COG1053@2|Bacteria,3Y6IU@57723|Acidobacteria,2JKAD@204432|Acidobacteriia 204432|Acidobacteriia C Fumarate reductase flavoprotein C-term - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_276245_1 13035.Dacsa_1323 1.6e-37 143.0 COG0768@1|root,COG0768@2|Bacteria,1G03W@1117|Cyanobacteria 1117|Cyanobacteria M Cell division protein FtsI penicillin-binding protein 2 mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_1006940_1 309801.trd_A0566 7.92e-76 235.0 COG1319@1|root,COG1319@2|Bacteria,2G84Z@200795|Chloroflexi,27Z3G@189775|Thermomicrobia 189775|Thermomicrobia C CO dehydrogenase flavoprotein C-terminal domain - - 1.2.5.3 ko:K03519 - - R11168 RC02800 ko00000,ko01000 - - - CO_deh_flav_C,FAD_binding_5 k59_954633_1 268746.Q58ML6_BPPRM 7.01e-63 194.0 4QE8Y@10239|Viruses,4QW3S@35237|dsDNA viruses no RNA stage,4QPGZ@28883|Caudovirales,4QISX@10662|Myoviridae 10662|Myoviridae S Recombination, repair and ssDNA binding protein UvsY - - - - - - - - - - - - - k59_954633_2 268746.Q58ML7_BPPRM 3.73e-63 197.0 4QAQQ@10239|Viruses,4QVZX@35237|dsDNA viruses no RNA stage,4QPBX@28883|Caudovirales,4QIBM@10662|Myoviridae 10662|Myoviridae S T4-like virus tail tube protein gp19 - - - - - - - - - - - - - k59_1059874_1 247634.GPB2148_187 6.8e-95 295.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_745895_1 298655.KI912266_gene4132 1.27e-27 115.0 COG0215@1|root,COG0730@1|root,COG0215@2|Bacteria,COG0730@2|Bacteria,2GJ4W@201174|Actinobacteria,4ERBT@85013|Frankiales 201174|Actinobacteria J PFAM Cysteinyl-tRNA synthetase class Ia - - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1e k59_646030_1 756275.H2BCS5_9CAUD 1.73e-36 142.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - GO:0008150,GO:0044403,GO:0044409,GO:0044411,GO:0044419,GO:0051701,GO:0051704,GO:0051828,GO:0051830,GO:0085027 - - - - - - - - - - - k59_1480797_1 523791.Kkor_2630 4.64e-124 367.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1XHRG@135619|Oceanospirillales 135619|Oceanospirillales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1427149_1 1229909.NSED_01230 2.13e-25 94.7 COG5466@1|root,arCOG05278@2157|Archaea,41T8X@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF1059) - - - - - - - - - - - - DUF1059 k59_1427149_2 436308.Nmar_0253 2.12e-37 133.0 COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota 651137|Thaumarchaeota C oxidoreductase FAD NAD(P)-binding - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_646037_1 1120953.AUBH01000014_gene2523 0.000126 47.8 COG0265@1|root,COG0265@2|Bacteria,1R9ZV@1224|Proteobacteria,1S2AZ@1236|Gammaproteobacteria,466XQ@72275|Alteromonadaceae 1236|Gammaproteobacteria O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - - - - - - - - - - Trypsin_2 k59_646037_2 1134445.AJJM01000016_gene314 3.66e-05 47.8 COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria 201174|Actinobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase k59_71375_1 232721.Ajs_3386 3.09e-82 255.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,4AB2U@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM fatty acid desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - DDE_Tnp_ISL3,FA_desaturase k59_1272821_1 1242864.D187_002072 7.88e-48 173.0 COG1640@1|root,COG1640@2|Bacteria,1QTDU@1224|Proteobacteria,437WN@68525|delta/epsilon subdivisions,2X36B@28221|Deltaproteobacteria,2YUHJ@29|Myxococcales 28221|Deltaproteobacteria G 4-alpha-glucanotransferase - - - - - - - - - - - - Glyco_hydro_77 k59_954639_1 472759.Nhal_1890 3.56e-72 222.0 COG1818@1|root,COG1818@2|Bacteria,1NEZ5@1224|Proteobacteria 1224|Proteobacteria S THUMP - - - - - - - - - - - - THUMP k59_954639_2 56780.SYN_01163 2.07e-76 236.0 COG0500@1|root,COG2226@2|Bacteria,1RFJD@1224|Proteobacteria,42S09@68525|delta/epsilon subdivisions,2WPB6@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q Methylase involved in ubiquinone menaquinone biosynthesis - - - - - - - - - - - - Methyltransf_11,Nitro_FeMo-Co k59_954639_3 472759.Nhal_2962 3.4e-17 80.1 COG0462@1|root,COG0462@2|Bacteria,1QHJ7@1224|Proteobacteria,1RZJH@1236|Gammaproteobacteria,1WZXT@135613|Chromatiales 135613|Chromatiales F Ribose-phosphate pyrophosphokinase - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_328903_1 330214.NIDE0545 1.54e-30 125.0 COG0745@1|root,COG2202@1|root,COG3290@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG3290@2|Bacteria 2|Bacteria T protein histidine kinase activity - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - GGDEF,HATPase_c,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SpoIIE,dCache_1 k59_745908_2 445686.E3SL94_9CAUD 1.54e-46 153.0 4QAY0@10239|Viruses,4QVSS@35237|dsDNA viruses no RNA stage,4QQ2W@28883|Caudovirales,4QJ6J@10662|Myoviridae 10662|Myoviridae S Hsp20/alpha crystallin family - - - - - - - - - - - - - k59_1112784_1 665959.HMPREF1013_03320 4.56e-35 139.0 COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,4H9T6@91061|Bacilli,1ZC1J@1386|Bacillus 91061|Bacilli S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_1582213_1 330214.NIDE1303 4.13e-123 385.0 COG0085@1|root,COG0085@2|Bacteria,3J0CW@40117|Nitrospirae 40117|Nitrospirae K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1635870_1 1229909.NSED_04595 1.42e-76 241.0 COG0498@1|root,arCOG01434@2157|Archaea,41S5N@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_382712_1 1380394.JADL01000011_gene3799 1.38e-49 169.0 COG0074@1|root,COG0074@2|Bacteria,1MX67@1224|Proteobacteria,2U0AT@28211|Alphaproteobacteria,2JU3W@204441|Rhodospirillales 204441|Rhodospirillales C Protein of unknown function (DUF1116) - - - - - - - - - - - - DUF1116 k59_382712_2 1197906.CAJQ02000043_gene2070 4.64e-13 70.5 COG0074@1|root,COG0074@2|Bacteria,1MWWN@1224|Proteobacteria,2TTYT@28211|Alphaproteobacteria,3JXIV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C CoA-ligase - - - - - - - - - - - - CoA_binding,Ligase_CoA k59_1319795_1 713586.KB900536_gene2532 4.15e-96 292.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1WW3A@135613|Chromatiales 135613|Chromatiales F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_1219640_1 1049564.TevJSym_ag00680 8.38e-42 148.0 COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,1RYIC@1236|Gammaproteobacteria 1236|Gammaproteobacteria C FAD dependent oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388,ko:K16885 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_oxidored,Pyr_redox_2 k59_1219640_2 292415.Tbd_1647 2.59e-65 219.0 COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,2WEVG@28216|Betaproteobacteria 28216|Betaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - ko:K16886 - - - - ko00000 - - - Fer4,FlpD,Pyr_redox_2 k59_590086_1 187272.Mlg_2442 2.75e-51 183.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1007739_1 110457.Q9MBZ1_9CAUD 7.02e-22 89.7 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales,4QNC3@10744|Podoviridae 10744|Podoviridae S endonuclease activity - - - - - - - - - - - - - k59_1007739_2 438753.AZC_3597 1.44e-24 103.0 COG0749@1|root,COG0749@2|Bacteria,1P27P@1224|Proteobacteria,2TVEI@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA polymerase family A - - - - - - - - - - - - DNA_pol_A k59_804102_1 402881.Plav_0358 0.000544 43.1 COG0784@1|root,COG3920@1|root,COG0784@2|Bacteria,COG3920@2|Bacteria,1NC9X@1224|Proteobacteria,2TYHT@28211|Alphaproteobacteria,1JP3K@119043|Rhodobiaceae 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - HWE_HK,Response_reg k59_804102_2 411466.ACTODO_00754 1.89e-35 130.0 COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,4D3V5@85005|Actinomycetales 201174|Actinobacteria C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_955367_1 570952.ATVH01000015_gene1382 2.06e-45 158.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2TS7B@28211|Alphaproteobacteria,2JQR2@204441|Rhodospirillales 204441|Rhodospirillales L Transposase - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_1273844_1 1260251.SPISAL_05885 4.68e-86 275.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1WXQF@135613|Chromatiales 135613|Chromatiales P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_1635899_1 426114.THI_1757 1.64e-65 224.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,1KJJ2@119065|unclassified Burkholderiales 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA2 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_537653_1 344747.PM8797T_14716 6.94e-19 81.6 2DX6Z@1|root,343NZ@2|Bacteria 2|Bacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_3 k59_1319812_1 1089552.KI911559_gene699 1.01e-21 100.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,2JR2R@204441|Rhodospirillales 204441|Rhodospirillales E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1582241_1 1278309.KB907102_gene15 1.08e-38 144.0 COG0836@1|root,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,1RNQI@1236|Gammaproteobacteria,1XH2I@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the mannose-6-phosphate isomerase type 2 family cpsB - 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_433622_1 1031711.RSPO_c02379 1.11e-14 75.5 COG0625@1|root,COG3832@1|root,COG0625@2|Bacteria,COG3832@2|Bacteria,1RC4Y@1224|Proteobacteria,2VW3S@28216|Betaproteobacteria,1KH88@119060|Burkholderiaceae 28216|Betaproteobacteria O Glutathione S-transferase gstF - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - AHSA1,GST_C,GST_N,GST_N_3 k59_433622_2 287.DR97_3411 2.37e-38 140.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,1RPPD@1236|Gammaproteobacteria,1YDBV@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Peptidase dimerisation domain - - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_955382_1 485913.Krac_3042 3.2e-56 190.0 COG1506@1|root,COG1506@2|Bacteria 2|Bacteria E serine-type peptidase activity - - 3.4.19.1 ko:K01303 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S9 k59_488239_1 1038859.AXAU01000028_gene28 2.5e-56 187.0 2BSZ4@1|root,32N30@2|Bacteria,1NTM8@1224|Proteobacteria,2UNVX@28211|Alphaproteobacteria,3K2SH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_120583_2 207954.MED92_01669 1.34e-45 155.0 COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,1RNBU@1236|Gammaproteobacteria,1XIMF@135619|Oceanospirillales 135619|Oceanospirillales S metal-binding protein - - - - - - - - - - - - NIF3 k59_1273869_1 290397.Adeh_3742 1.21e-11 67.0 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,43AM0@68525|delta/epsilon subdivisions,2X615@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.1.1.41 ko:K11264 ko00640,map00640 - R00923 RC00097 ko00000,ko00001,ko01000 - - - ECH_1 k59_1273869_2 981336.F944_02357 7.36e-14 71.6 COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,1SYG7@1236|Gammaproteobacteria,3NTAA@468|Moraxellaceae 1236|Gammaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_746686_1 215803.DB30_5880 1.85e-26 113.0 COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,42Z37@68525|delta/epsilon subdivisions,2WUNE@28221|Deltaproteobacteria,2YZFR@29|Myxococcales 28221|Deltaproteobacteria Q Multicopper oxidase - - - - - - - - - - - - - k59_804133_2 243233.MCA1467 1.05e-141 416.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XE25@135618|Methylococcales 135618|Methylococcales M Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_433640_1 1232410.KI421425_gene1546 4.47e-81 246.0 COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,42TN7@68525|delta/epsilon subdivisions,2WQK7@28221|Deltaproteobacteria,43TGA@69541|Desulfuromonadales 28221|Deltaproteobacteria U MotA/TolQ/ExbB proton channel family - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_851464_1 338966.Ppro_0583 1.09e-17 80.1 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,42MTF@68525|delta/epsilon subdivisions,2WJ6X@28221|Deltaproteobacteria,43T9A@69541|Desulfuromonadales 28221|Deltaproteobacteria D PFAM Cobyrinic acid a,c-diamide synthase soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_851464_2 999423.HMPREF9161_01283 2.21e-13 74.3 COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,4H2EW@909932|Negativicutes 909932|Negativicutes J Specifically methylates the N7 position of a guanine in 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_1163347_3 656519.Halsa_0338 2e-28 108.0 COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,3WB9U@53433|Halanaerobiales 186801|Clostridia L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - HHH,RecR,Toprim_4 k59_1428194_1 246197.MXAN_2742 1.45e-27 115.0 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,42M2B@68525|delta/epsilon subdivisions,2WJDZ@28221|Deltaproteobacteria,2YTWQ@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the biosynthesis of agmatine from arginine speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_1428194_2 626522.GCWU000325_01271 3.98e-16 78.6 COG0388@1|root,COG0388@2|Bacteria,4NEME@976|Bacteroidetes,2FMCZ@200643|Bacteroidia,1WCZ8@1283313|Alloprevotella 976|Bacteroidetes S Carbon-nitrogen hydrolase pabB - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_804168_2 1229780.BN381_130222 6.73e-138 398.0 COG1024@1|root,COG1024@2|Bacteria,2GN3P@201174|Actinobacteria 201174|Actinobacteria I Enoyl-CoA hydratase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_433671_1 290318.Cvib_0385 5.87e-06 48.5 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1FEF9@1090|Chlorobi 1090|Chlorobi C electron transfer flavoprotein-ubiquinone oxidoreductase - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO k59_488295_1 1382359.JIAL01000001_gene680 2.56e-47 165.0 COG0719@1|root,COG0719@2|Bacteria,3Y4EK@57723|Acidobacteria 57723|Acidobacteria O Uncharacterized protein family (UPF0051) - - - ko:K09015 - - - - ko00000 - - - UPF0051 k59_488295_2 1128421.JAGA01000002_gene1805 3.98e-34 122.0 COG0822@1|root,COG0822@2|Bacteria,2NPXN@2323|unclassified Bacteria 2|Bacteria C NifU-like N terminal domain nifU - - ko:K04488 - - - - ko00000 - - - NifU_N k59_903944_1 1440774.Y900_020830 6.68e-61 199.0 COG0183@1|root,COG0183@2|Bacteria,2IDAP@201174|Actinobacteria,233A4@1762|Mycobacteriaceae 201174|Actinobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_488300_1 1267535.KB906767_gene2302 7.64e-50 172.0 COG0577@1|root,COG0577@2|Bacteria,3Y6CK@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1112872_1 69279.BG36_09595 2.64e-116 351.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,43HBK@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_537712_1 1123290.AUDQ01000008_gene2116 6.95e-09 55.1 COG0454@1|root,COG0456@2|Bacteria,1V4R5@1239|Firmicutes,4HGWU@91061|Bacilli 91061|Bacilli K L-2,4-diaminobutyric acid acetyltransferase ectA - 2.3.1.178 ko:K06718 ko00260,ko01100,ko01120,map00260,map01100,map01120 M00033 R06978 RC00004,RC00096 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1 k59_537712_2 472759.Nhal_2707 1.78e-122 361.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,1RQKU@1236|Gammaproteobacteria,1WXFB@135613|Chromatiales 135613|Chromatiales H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.76 ko:K00836 ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230 M00033 R06977 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1219754_1 1144275.COCOR_03152 1.9e-76 255.0 COG3391@1|root,COG3391@2|Bacteria,1R66T@1224|Proteobacteria,439FZ@68525|delta/epsilon subdivisions,2X4RS@28221|Deltaproteobacteria,2YZGC@29|Myxococcales 28221|Deltaproteobacteria G 6-phosphogluconolactonase activity - - - - - - - - - - - - - k59_1635992_1 445686.E3SL77_9CAUD 1.62e-156 463.0 4QAKZ@10239|Viruses,4QUSW@35237|dsDNA viruses no RNA stage,4QPYH@28883|Caudovirales,4QIYN@10662|Myoviridae 10662|Myoviridae S exonuclease activity - - - - - - - - - - - - - k59_955444_2 247634.GPB2148_756 9.24e-29 117.0 COG0535@1|root,COG0535@2|Bacteria,1NEM7@1224|Proteobacteria 1224|Proteobacteria M radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_1163384_1 706587.Desti_5251 3.76e-61 195.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,42MZP@68525|delta/epsilon subdivisions,2WJ1Z@28221|Deltaproteobacteria,2MQWW@213462|Syntrophobacterales 28221|Deltaproteobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_647152_1 436308.Nmar_1309 1.65e-120 363.0 COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S7I@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18594 ko00720,ko01120,map00720,map01120 - R03157 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_804202_1 502025.Hoch_4016 1.21e-71 243.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2YUEA@29|Myxococcales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1112886_1 472759.Nhal_3162 6.77e-80 256.0 COG3829@1|root,COG3829@2|Bacteria,1MXSB@1224|Proteobacteria,1RVV6@1236|Gammaproteobacteria,1WWEN@135613|Chromatiales 135613|Chromatiales K Sigma-54 interaction domain - - - - - - - - - - - - Sigma54_activat k59_433702_1 452637.Oter_2407 3.26e-10 67.8 COG4191@1|root,COG4191@2|Bacteria,46W3V@74201|Verrucomicrobia,3K9SN@414999|Opitutae 414999|Opitutae T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_1013903_1 886293.Sinac_0967 2.2e-53 189.0 COG0841@1|root,COG0841@2|Bacteria,2IX3P@203682|Planctomycetes 203682|Planctomycetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_80461_1 1270193.JARP01000004_gene1484 8.44e-15 77.0 COG2068@1|root,COG2068@2|Bacteria,4NQNF@976|Bacteroidetes,1I2S6@117743|Flavobacteriia,2NSZJ@237|Flavobacterium 976|Bacteroidetes S Molybdopterin-guanine dinucleotide biosynthesis protein MobA - - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_857653_1 713586.KB900536_gene166 5.85e-106 312.0 COG3298@1|root,COG3298@2|Bacteria,1MVZJ@1224|Proteobacteria,1S4HU@1236|Gammaproteobacteria 1236|Gammaproteobacteria L 3'-5' exonuclease related to the exonuclease domain of PolB - - - ko:K07501 - - - - ko00000 - - - DNA_pol_B_exo2 k59_655137_1 338966.Ppro_1665 1.94e-11 63.5 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,42RK3@68525|delta/epsilon subdivisions,2WNES@28221|Deltaproteobacteria,43U3M@69541|Desulfuromonadales 28221|Deltaproteobacteria F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_655137_2 1125863.JAFN01000001_gene1963 1.21e-23 102.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdJ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD k59_127681_3 1121957.ATVL01000006_gene2857 7.84e-62 193.0 COG0048@1|root,COG0048@2|Bacteria,4NM3Y@976|Bacteroidetes,47PCE@768503|Cytophagia 976|Bacteroidetes J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_1642935_1 335543.Sfum_3556 2.14e-73 229.0 COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,42MI8@68525|delta/epsilon subdivisions,2WJDT@28221|Deltaproteobacteria,2MQ5W@213462|Syntrophobacterales 28221|Deltaproteobacteria M Male sterility protein uxs - 4.1.1.35 ko:K08678 ko00520,ko01100,map00520,map01100 M00361 R01384 RC00508 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_335619_1 911045.PSE_1955 2.07e-35 133.0 COG0673@1|root,COG0673@2|Bacteria 2|Bacteria S inositol 2-dehydrogenase activity - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_1379373_1 864069.MicloDRAFT_00010690 1.59e-120 360.0 COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,2TQPC@28211|Alphaproteobacteria,1JXET@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Homeodomain-like domain - - - - - - - - - - - - HTH_28,HTH_29,HTH_32,rve k59_1167875_1 391625.PPSIR1_40085 1.01e-78 248.0 COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,42PRH@68525|delta/epsilon subdivisions,2WPXH@28221|Deltaproteobacteria,2YV87@29|Myxococcales 28221|Deltaproteobacteria CH Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ,MobB k59_1167875_2 378806.STAUR_1774 1.07e-25 101.0 COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,42W4M@68525|delta/epsilon subdivisions,2X5QP@28221|Deltaproteobacteria,2Z36W@29|Myxococcales 28221|Deltaproteobacteria S Pfam:DUF59 - - - - - - - - - - - - FeS_assembly_P k59_1167875_3 1183438.GKIL_1934 6.28e-48 157.0 COG0822@1|root,COG0822@2|Bacteria,1G590@1117|Cyanobacteria 1117|Cyanobacteria C SUF system FeS assembly protein, NifU family - - - ko:K04488 - - - - ko00000 - - - NifU_N k59_1642951_1 1207063.P24_08584 4.12e-77 241.0 COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,2TRM7@28211|Alphaproteobacteria,2JR24@204441|Rhodospirillales 204441|Rhodospirillales E FAD dependent oxidoreductase - - 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO k59_1642951_2 1479235.KK366039_gene1995 2.13e-72 231.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1XH2G@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism - - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_1013916_1 1047171.Mycgr3P72887 2.62e-11 65.5 COG0642@1|root,KOG0519@2759|Eukaryota,391YN@33154|Opisthokonta,3NV7C@4751|Fungi,3QPHU@4890|Ascomycota,1ZYFD@147541|Dothideomycetes,3MFQK@451867|Dothideomycetidae 4751|Fungi T GAF domain CHK1 GO:0000155,GO:0000160,GO:0001932,GO:0001934,GO:0002831,GO:0002833,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0007162,GO:0007165,GO:0008150,GO:0008152,GO:0009272,GO:0009365,GO:0009405,GO:0009607,GO:0009893,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010562,GO:0010570,GO:0010604,GO:0010646,GO:0010647,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019220,GO:0019222,GO:0019538,GO:0022407,GO:0022408,GO:0023014,GO:0023051,GO:0023052,GO:0023056,GO:0030100,GO:0030155,GO:0030447,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032268,GO:0032270,GO:0032872,GO:0032874,GO:0032879,GO:0032991,GO:0033554,GO:0033993,GO:0034599,GO:0035556,GO:0036180,GO:0036211,GO:0040007,GO:0040008,GO:0042221,GO:0042325,GO:0042327,GO:0042546,GO:0042710,GO:0043170,GO:0043408,GO:0043410,GO:0043412,GO:0043900,GO:0044010,GO:0044011,GO:0044085,GO:0044182,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044764,GO:0045806,GO:0045927,GO:0045937,GO:0046677,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0050764,GO:0050765,GO:0050789,GO:0050794,GO:0050896,GO:0051040,GO:0051042,GO:0051049,GO:0051051,GO:0051128,GO:0051129,GO:0051171,GO:0051173,GO:0051174,GO:0051246,GO:0051247,GO:0051703,GO:0051704,GO:0051716,GO:0060255,GO:0060627,GO:0061695,GO:0065007,GO:0070302,GO:0070304,GO:0070887,GO:0070994,GO:0071236,GO:0071310,GO:0071396,GO:0071554,GO:0071704,GO:0071840,GO:0071852,GO:0080090,GO:0080134,GO:0080135,GO:0090033,GO:0090605,GO:0090609,GO:0097305,GO:0097306,GO:0097307,GO:0097308,GO:0140096,GO:1900190,GO:1900231,GO:1900428,GO:1900430,GO:1900443,GO:1900445,GO:1901564,GO:1901700,GO:1901701,GO:1902494,GO:1902531,GO:1902533,GO:1902911,GO:1990234 2.7.13.3 ko:K19690 ko02020,map02020 M00516 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,Pkinase,Response_reg k59_1013916_2 1382306.JNIM01000001_gene3126 1.1e-39 151.0 COG0683@1|root,COG0683@2|Bacteria,2G6Q1@200795|Chloroflexi 200795|Chloroflexi E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_440487_1 83406.HDN1F_08610 6.6e-28 108.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,1J5PU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN746.PP_4715 TIM k59_440487_2 472759.Nhal_3701 6.88e-26 101.0 COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,1SD3P@1236|Gammaproteobacteria,1WZFD@135613|Chromatiales 135613|Chromatiales U PFAM Preprotein translocase SecG subunit secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_702602_1 68223.JNZY01000047_gene2093 9.91e-18 83.2 COG2267@1|root,COG2267@2|Bacteria,2I9JC@201174|Actinobacteria 201174|Actinobacteria I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Hydrolase_4 k59_1282206_1 1047013.AQSP01000132_gene1748 7.48e-141 429.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2NNNY@2323|unclassified Bacteria 2|Bacteria G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.3.13,2.7.9.1 ko:K01006,ko:K22424 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_961046_2 1229780.BN381_10325 2.44e-19 88.6 COG0076@1|root,COG0076@2|Bacteria,2GKIH@201174|Actinobacteria,3UWJB@52018|unclassified Actinobacteria (class) 201174|Actinobacteria E Pyridoxal-dependent decarboxylase conserved domain - - 4.1.1.11,4.1.1.25,4.1.2.27 ko:K01634,ko:K18933 ko00350,ko00410,ko00600,ko00680,ko00770,ko01100,ko01110,ko04071,map00350,map00410,map00600,map00680,map00770,map01100,map01110,map04071 M00100 R00489,R00736,R02464,R06516 RC00264,RC00299,RC00721,RC01266 ko00000,ko00001,ko00002,ko01000 - - - Pyridoxal_deC k59_230415_1 1121422.AUMW01000003_gene867 1.59e-30 120.0 COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,260BA@186807|Peptococcaceae 186801|Clostridia C electron transfer flavoprotein, alpha subunit etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha,Fer4 k59_496368_1 1120965.AUBV01000015_gene1110 3.82e-51 184.0 COG2355@1|root,COG2355@2|Bacteria,4NP5X@976|Bacteroidetes,47PUH@768503|Cytophagia 976|Bacteroidetes E Zn-dependent dipeptidase, microsomal dipeptidase - - - - - - - - - - - - - k59_910041_1 215803.DB30_7321 1.43e-47 155.0 2CI53@1|root,32S7C@2|Bacteria,1RE39@1224|Proteobacteria,430ZA@68525|delta/epsilon subdivisions,2WW1C@28221|Deltaproteobacteria,2Z0S8@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1642979_2 1229780.BN381_290074 1.68e-44 153.0 COG0208@1|root,COG0208@2|Bacteria 2|Bacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - - - - - - - - - - - Ald_deCOase k59_80521_1 99598.Cal7507_3827 2.43e-61 207.0 COG2192@1|root,COG2192@2|Bacteria,1G1FV@1117|Cyanobacteria,1HMHD@1161|Nostocales 1117|Cyanobacteria O Carbamoyltransferase C-terminus - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_1226687_1 909663.KI867151_gene3160 2.53e-18 82.4 COG2197@1|root,COG2197@2|Bacteria,1RARA@1224|Proteobacteria,43B1G@68525|delta/epsilon subdivisions,2X5U5@28221|Deltaproteobacteria,2MRK4@213462|Syntrophobacterales 28221|Deltaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_1489860_2 323848.Nmul_A1663 1.79e-14 72.8 COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,372TF@32003|Nitrosomonadales 28216|Betaproteobacteria KT PFAM Metal-dependent phosphohydrolase, HD - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,GAF_2,HD k59_702630_1 1089552.KI911559_gene1139 3.4e-42 150.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TU9X@28211|Alphaproteobacteria,2JR0M@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation metE - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_1,Meth_synt_2 k59_596230_1 1120998.AUFC01000051_gene568 7.47e-13 63.5 2DQE0@1|root,33689@2|Bacteria,1VH8J@1239|Firmicutes,24WJ6@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_389828_1 324602.Caur_1783 1.19e-40 153.0 COG2211@1|root,COG2211@2|Bacteria,2G6RZ@200795|Chloroflexi 200795|Chloroflexi G MFS/sugar transport protein - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_1167908_1 1094980.Mpsy_2024 5.72e-87 266.0 COG1260@1|root,arCOG04213@2157|Archaea,2XVGK@28890|Euryarchaeota,2N96M@224756|Methanomicrobia 224756|Methanomicrobia I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth k59_127754_1 247490.KSU1_C0628 5.05e-28 110.0 COG1912@1|root,COG1912@2|Bacteria,2IZNZ@203682|Planctomycetes 203682|Planctomycetes S S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans k59_1489868_1 525904.Tter_0058 2.08e-74 240.0 COG0154@1|root,COG0154@2|Bacteria,2NNSD@2323|unclassified Bacteria 2|Bacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1643005_1 1693.BMIN_0648 1.13e-09 59.3 COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4CYQW@85004|Bifidobacteriales 201174|Actinobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_1643005_2 713586.KB900536_gene2168 1.03e-34 130.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1WYMY@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase k59_1588501_1 1207063.P24_06931 1.62e-41 140.0 COG0251@1|root,COG0251@2|Bacteria,1MZ5K@1224|Proteobacteria,2U9DU@28211|Alphaproteobacteria,2JTAM@204441|Rhodospirillales 204441|Rhodospirillales J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_1588501_2 28258.KP05_15020 4.5e-06 49.3 COG0451@1|root,COG0451@2|Bacteria,1MU1A@1224|Proteobacteria,1RQD8@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0451 Nucleoside-diphosphate-sugar epimerases - - 1.1.1.410,5.1.3.2 ko:K01784,ko:K22025 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_752729_1 1515613.HQ37_03130 6.78e-16 80.5 COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,2FMPG@200643|Bacteroidia 976|Bacteroidetes T acetoacetate metabolism regulatory protein AtoC K07714 - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_752729_2 999419.HMPREF1077_00702 1.79e-09 62.4 COG5000@1|root,COG5000@2|Bacteria,4NFQN@976|Bacteroidetes,2FQJW@200643|Bacteroidia,22Z6G@171551|Porphyromonadaceae 976|Bacteroidetes T PAS domain - - - - - - - - - - - - HATPase_c,PAS,PAS_8 k59_812341_1 1192034.CAP_4238 5.01e-09 57.8 COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,42S7G@68525|delta/epsilon subdivisions,2WNH7@28221|Deltaproteobacteria,2YYYG@29|Myxococcales 28221|Deltaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_812341_2 479433.Caci_5359 2e-67 208.0 COG2030@1|root,COG2030@2|Bacteria,2IPFP@201174|Actinobacteria 201174|Actinobacteria I MaoC like domain - - - - - - - - - - - - MaoC_dehydratas k59_596253_2 285514.JNWO01000002_gene4905 7.21e-49 171.0 COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria 201174|Actinobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_335696_1 1457393.AZ09_03460 2.51e-20 87.8 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2U59K@28211|Alphaproteobacteria,2JS03@204441|Rhodospirillales 204441|Rhodospirillales O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_702666_1 1300345.LF41_1650 8.38e-31 108.0 COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,1SC8Q@1236|Gammaproteobacteria,1X88Q@135614|Xanthomonadales 135614|Xanthomonadales C rubredoxin rubA - - - - - - - - - - - Rubredoxin k59_1379453_1 555778.Hneap_0941 1.25e-19 95.5 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1WWJF@135613|Chromatiales 135613|Chromatiales M TIGRFAM RHS repeat-associated core domain - - - - - - - - - - - - RHS,RHS_repeat k59_283300_1 1242864.D187_001017 1.88e-68 234.0 COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,42MX2@68525|delta/epsilon subdivisions,2WIUV@28221|Deltaproteobacteria 28221|Deltaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_812363_1 1116472.MGMO_53c00310 3.5e-64 199.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,1S4VI@1236|Gammaproteobacteria,1XF76@135618|Methylococcales 135618|Methylococcales O PFAM Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_496449_1 1384484.AEQU_0871 4.37e-12 69.3 COG1597@1|root,COG1597@2|Bacteria,2GK3P@201174|Actinobacteria,4CV1Y@84998|Coriobacteriia 84998|Coriobacteriia I lipid kinase, YegS Rv2252 BmrU family - - - - - - - - - - - - DAGK_cat k59_496449_2 1118235.CAJH01000025_gene1809 6.79e-33 129.0 COG2132@1|root,COG2132@2|Bacteria,1PE36@1224|Proteobacteria,1RYCS@1236|Gammaproteobacteria,1X8PP@135614|Xanthomonadales 135614|Xanthomonadales Q Multicopper oxidase - - 1.10.3.3 ko:K00423 ko00053,ko01100,map00053,map01100 - R00068 RC00092 ko00000,ko00001,ko01000 - - - Cu-oxidase_2,Cu-oxidase_3 k59_961117_1 491952.Mar181_1270 2.43e-15 75.5 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1XH5E@135619|Oceanospirillales 135619|Oceanospirillales C 2-oxoglutarate dehydrogenase complex lpdG - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_961117_2 1049564.TevJSym_at00030 6.93e-45 156.0 28I2K@1|root,2Z86N@2|Bacteria,1R1GA@1224|Proteobacteria,1RRPU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1118765_1 561175.KB894094_gene1771 5.81e-36 135.0 COG2141@1|root,COG2141@2|Bacteria,2GKP1@201174|Actinobacteria,4EI5A@85012|Streptosporangiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1379456_1 991905.SL003B_0529 2.03e-15 82.0 COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2TR02@28211|Alphaproteobacteria,4BT81@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_10218_1 349124.Hhal_0987 2.12e-68 213.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,1RPK3@1236|Gammaproteobacteria,1WWEP@135613|Chromatiales 135613|Chromatiales J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_857762_1 987059.RBXJA2T_08013 3.67e-78 247.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,1KJ4Y@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Dehydrogenase odhL GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_1226773_1 1192034.CAP_5303 7.16e-73 239.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YUJ9@29|Myxococcales 28221|Deltaproteobacteria T Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_1643076_1 395493.BegalDRAFT_1819 9.52e-40 142.0 COG0789@1|root,COG0789@2|Bacteria,1R9SN@1224|Proteobacteria,1S78T@1236|Gammaproteobacteria,463IS@72273|Thiotrichales 72273|Thiotrichales K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 k59_1436193_1 1284708.HMPREF1634_06555 1.33e-76 256.0 COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,3WCXH@538999|Clostridiales incertae sedis 186801|Clostridia F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1282345_1 864073.HFRIS_021988 1.06e-57 194.0 COG4630@1|root,COG4630@2|Bacteria,1MWI1@1224|Proteobacteria,2VI0J@28216|Betaproteobacteria 28216|Betaproteobacteria C Xanthine dehydrogenase small subunit xdhA - 1.17.1.4 ko:K13481 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2 k59_1066896_1 472175.EL18_02166 4.29e-45 160.0 COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,43H44@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Citrate transporter - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_1014030_1 1415779.JOMH01000001_gene2889 4.67e-08 57.4 COG0664@1|root,COG0664@2|Bacteria,1RE4X@1224|Proteobacteria,1S6Z7@1236|Gammaproteobacteria,1X91Q@135614|Xanthomonadales 135614|Xanthomonadales K Cyclic nucleotide-monophosphate binding domain - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1014030_3 269796.Rru_A3213 7.29e-05 44.3 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,2JQVJ@204441|Rhodospirillales 204441|Rhodospirillales T transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,PAS_9 k59_544442_1 671143.DAMO_0751 2.06e-78 244.0 COG0638@1|root,COG0638@2|Bacteria,2NQJR@2323|unclassified Bacteria 2|Bacteria O Proteasome subunit prcB GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome k59_911145_1 298386.PBPRB0650 3.97e-109 339.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,1XU9K@135623|Vibrionales 1224|Proteobacteria C Catalytic subunit of the nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC. Essential function for nitrate assimilation and may have a role in anaerobic metabolism - - - ko:K02567 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_858732_2 399795.CtesDRAFT_PD5491 2.18e-09 60.8 COG1960@1|root,COG1960@2|Bacteria,1R6EH@1224|Proteobacteria,2WGBA@28216|Betaproteobacteria 28216|Betaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_597253_1 1173027.Mic7113_1202 2.81e-77 250.0 COG1506@1|root,COG1506@2|Bacteria,1G200@1117|Cyanobacteria,1H8T3@1150|Oscillatoriales 1117|Cyanobacteria E PFAM Prolyl oligopeptidase family dap2 - - - - - - - - - - - PD40,Peptidase_S9 k59_753761_1 1283300.ATXB01000001_gene1010 3.95e-75 241.0 COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,1RZ41@1236|Gammaproteobacteria,1XEKE@135618|Methylococcales 1236|Gammaproteobacteria T TIGRFAM Diguanylate cyclase - - - - - - - - - - - - GGDEF k59_599675_1 1026882.MAMP_01033 6.32e-73 224.0 COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,460KS@72273|Thiotrichales 72273|Thiotrichales U MotA TolQ ExbB proton channel family - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_756207_1 1131269.AQVV01000020_gene2195 1.02e-80 248.0 COG1173@1|root,COG1173@2|Bacteria 2|Bacteria P ABC-type dipeptide oligopeptide nickel transport systems, permease components appC - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_756207_2 553184.ATORI0001_0250 2.67e-12 67.4 COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria 201174|Actinobacteria O Belongs to the ABC transporter superfamily oppD GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_659843_2 1123371.ATXH01000018_gene1402 3.33e-72 240.0 COG0466@1|root,COG0466@2|Bacteria,2GGZQ@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_659845_1 926569.ANT_25720 3.53e-62 198.0 COG4555@1|root,COG4555@2|Bacteria 2|Bacteria CP ABC transporter natA - 3.6.3.7 ko:K09697 ko02010,ko02020,map02010,map02020 M00253 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.115 - iYO844.BSU02750 ABC_tran k59_132085_1 519442.Huta_1526 3.12e-06 52.0 COG1171@1|root,arCOG01431@2157|Archaea,2XT4W@28890|Euryarchaeota,23SNZ@183963|Halobacteria 183963|Halobacteria E Threonine dehydratase ilvA1 - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT_4,PALP k59_132085_2 518766.Rmar_2719 6.69e-20 90.5 COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes 976|Bacteroidetes Q COG1228 Imidazolonepropionase and related - - - - - - - - - - - - Amidohydro_1 k59_444819_1 1122197.ATWI01000008_gene2665 1.09e-188 543.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,4651B@72275|Alteromonadaceae 1236|Gammaproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tktA GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c27750,iLF82_1304.LF82_2271,iNRG857_1313.NRG857_12300,iSDY_1059.SDY_3141,iYL1228.KPN_01127,iYL1228.KPN_02799,ic_1306.c2990 Transket_pyr,Transketolase_C,Transketolase_N k59_11656_1 1121878.AUGL01000002_gene2195 1.61e-42 151.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033817,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b1095,iAPECO1_1312.APECO1_176,iB21_1397.B21_01099,iBWG_1329.BWG_0943,iE2348C_1286.E2348C_1187,iEC042_1314.EC042_1165,iEC55989_1330.EC55989_1207,iECABU_c1320.ECABU_c13085,iECBD_1354.ECBD_2506,iECB_1328.ECB_01091,iECDH10B_1368.ECDH10B_1167,iECDH1ME8569_1439.ECDH1ME8569_1030,iECD_1391.ECD_01091,iECED1_1282.ECED1_1238,iECH74115_1262.ECH74115_1474,iECIAI1_1343.ECIAI1_1130,iECIAI39_1322.ECIAI39_2066,iECO103_1326.ECO103_1140,iECO111_1330.ECO111_1372,iECO26_1355.ECO26_1428,iECOK1_1307.ECOK1_1202,iECP_1309.ECP_1087,iECS88_1305.ECS88_1109,iECSE_1348.ECSE_1159,iECSF_1327.ECSF_0994,iECSP_1301.ECSP_1396,iECUMN_1333.ECUMN_1270,iECW_1372.ECW_m1203,iECs_1301.ECs1473,iEKO11_1354.EKO11_2739,iETEC_1333.ETEC_1160,iEcDH1_1363.EcDH1_2552,iEcE24377_1341.EcE24377A_1216,iEcSMS35_1347.EcSMS35_2032,iG2583_1286.G2583_1355,iJO1366.b1095,iJR904.b1095,iLF82_1304.LF82_0607,iNRG857_1313.NRG857_05280,iSF_1195.SF1099,iSFxv_1172.SFxv_1251,iS_1188.S1179,iUMN146_1321.UM146_11850,iWFL_1372.ECW_m1203,iY75_1357.Y75_RS05720,iZ_1308.Z1734,ic_1306.c1365 Ketoacyl-synt_C,ketoacyl-synt k59_11656_2 7213.XP_004527970.1 2.4e-24 101.0 COG0236@1|root,COG0304@1|root,KOG1394@2759|Eukaryota,KOG1748@2759|Eukaryota,38H9Y@33154|Opisthokonta,3BF6J@33208|Metazoa,3CYM9@33213|Bilateria,41XX5@6656|Arthropoda,3SKFX@50557|Insecta,44XVE@7147|Diptera 33208|Metazoa I Transferase activity, transferring acyl groups other than amino-acyl groups. It is involved in the biological process described with fatty acid biosynthetic process - - - - - - - - - - - - Ketoacyl-synt_C,PP-binding,ketoacyl-synt k59_501003_2 243233.MCA0291 3.32e-43 153.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1XESH@135618|Methylococcales 135618|Methylococcales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_85102_2 479435.Kfla_6631 1.02e-28 115.0 COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4DP2R@85009|Propionibacteriales 201174|Actinobacteria EG Dehydratase family - - - - - - - - - - - - ILVD_EDD k59_132095_1 1458275.AZ34_14955 3.07e-14 78.6 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,4AA4E@80864|Comamonadaceae 28216|Betaproteobacteria M TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family lolC - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_756218_1 472759.Nhal_3717 4.17e-34 130.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1WW09@135613|Chromatiales 135613|Chromatiales CH Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 - - - ko:K03185 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04989,R08773 RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_1532530_1 543526.Htur_1030 5.51e-28 117.0 COG0277@1|root,arCOG00340@2157|Archaea,2Y85H@28890|Euryarchaeota,24157@183963|Halobacteria 183963|Halobacteria C COG0277 FAD FMN-containing dehydrogenases - - - - - - - - - - - - BBE,FAD_binding_4 k59_964661_1 1121403.AUCV01000012_gene4117 3.07e-22 93.2 COG3584@1|root,COG3584@2|Bacteria 2|Bacteria T 3D domain protein DR0488 - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - 3D,NLPC_P60,Peptidase_M23 k59_816893_1 751994.AGIG01000035_gene357 6.3e-140 415.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1J7VQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F 5'-nucleotidase, C-terminal domain soxB - - ko:K17224 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - 5_nucleotid_C k59_1382431_1 1267533.KB906735_gene5088 1.65e-12 68.9 COG0618@1|root,COG0618@2|Bacteria,3Y2GZ@57723|Acidobacteria,2JI0W@204432|Acidobacteriia 204432|Acidobacteriia S DHH family - - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_1382431_2 880072.Desac_2291 4.44e-25 102.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,42MU5@68525|delta/epsilon subdivisions,2WKWY@28221|Deltaproteobacteria,2MQI6@213462|Syntrophobacterales 28221|Deltaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB_C_2,TruB_N k59_546801_1 1229909.NSED_04255 6.76e-80 239.0 COG1259@1|root,arCOG01759@2157|Archaea,41SQI@651137|Thaumarchaeota 651137|Thaumarchaeota S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase k59_1017480_1 1200792.AKYF01000011_gene3445 6.96e-36 130.0 COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,4HA37@91061|Bacilli,26S30@186822|Paenibacillaceae 91061|Bacilli I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_1017480_2 935948.KE386494_gene258 3.12e-55 179.0 COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,24HWS@186801|Clostridia,42FRZ@68295|Thermoanaerobacterales 186801|Clostridia J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_861253_1 1469245.JFBG01000061_gene2296 5.86e-78 245.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1WWD4@135613|Chromatiales 135613|Chromatiales J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_756231_1 754477.Q7C_780 2.01e-49 165.0 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,460JH@72273|Thiotrichales 72273|Thiotrichales O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_756231_2 1122194.AUHU01000007_gene284 8.2e-18 81.6 COG3147@1|root,COG3147@2|Bacteria,1N9GW@1224|Proteobacteria,1T2WQ@1236|Gammaproteobacteria,46DE4@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 k59_1494424_1 400682.PAC_15703144 1.22e-132 389.0 COG0365@1|root,KOG1175@2759|Eukaryota,38BR4@33154|Opisthokonta,3BE2N@33208|Metazoa 33208|Metazoa I acetate-CoA ligase activity - - - - - - - - - - - - ACAS_N,AMP-binding,AMP-binding_C k59_85137_1 240016.ABIZ01000001_gene965 5.81e-57 190.0 COG0760@1|root,COG0760@2|Bacteria,46VUP@74201|Verrucomicrobia,2IVK4@203494|Verrucomicrobiae 203494|Verrucomicrobiae O PPIC-type PPIASE domain - - - - - - - - - - - - Rotamase_2 k59_1592108_1 1163408.UU9_07718 5.93e-13 66.6 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1X3QU@135614|Xanthomonadales 135614|Xanthomonadales J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_1592108_2 630626.EBL_c39170 2.14e-29 114.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Stress-induced protein yicC GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575 - - - - - - - - - - DUF1732,YicC_N k59_1017499_1 768066.HELO_3866 1.17e-33 128.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1XH4G@135619|Oceanospirillales 135619|Oceanospirillales P Mg2 and Co2 transporter CorB - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1017500_1 882378.RBRH_02171 3e-62 202.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2VHSQ@28216|Betaproteobacteria,1K0Y0@119060|Burkholderiaceae 28216|Betaproteobacteria C Cytochrome d ubiquinol oxidase, subunit II cydB - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_756244_1 875328.JDM601_3807 4.27e-08 61.2 COG0451@1|root,COG3848@1|root,COG0451@2|Bacteria,COG3848@2|Bacteria,2I789@201174|Actinobacteria 201174|Actinobacteria T PEP-utilising enzyme, mobile domain - - - - - - - - - - - - PEP-utilizers k59_1122339_1 330214.NIDE0399 1.28e-90 283.0 COG0072@1|root,COG0072@2|Bacteria,3J0U7@40117|Nitrospirae 40117|Nitrospirae J B3/4 domain - - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B5 k59_1286983_1 269799.Gmet_2526 8.71e-15 71.2 COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,42SG5@68525|delta/epsilon subdivisions,2WNPI@28221|Deltaproteobacteria,43UXJ@69541|Desulfuromonadales 28221|Deltaproteobacteria L Staphylococcal nuclease homologues - - - - - - - - - - - - Ada_Zn_binding,Excalibur,SNase k59_1122340_1 765913.ThidrDRAFT_1095 1.32e-19 92.4 COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,1RR67@1236|Gammaproteobacteria,1WX31@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_1122345_1 373903.Hore_20360 0.00029 43.1 COG2812@1|root,COG2812@2|Bacteria,1VCQC@1239|Firmicutes,248U4@186801|Clostridia,3WAJV@53433|Halanaerobiales 186801|Clostridia L TIGRFAM DNA polymerase III, delta holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C k59_659916_2 1463936.JOJI01000011_gene1097 1.69e-55 184.0 COG1545@1|root,COG1545@2|Bacteria,2GJHW@201174|Actinobacteria 201174|Actinobacteria I nucleic-acid-binding protein containing a Zn-ribbon - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_233829_1 1122603.ATVI01000008_gene2232 1.22e-55 195.0 COG0664@1|root,COG1033@1|root,COG0664@2|Bacteria,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1X3P5@135614|Xanthomonadales 135614|Xanthomonadales T Sterol-sensing domain of SREBP cleavage-activation - - - - - - - - - - - - MMPL,cNMP_binding k59_85168_1 96561.Dole_0151 3.72e-76 243.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2MI5B@213118|Desulfobacterales 28221|Deltaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1647677_1 290397.Adeh_3006 1.88e-10 58.5 COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,42VRD@68525|delta/epsilon subdivisions,2WSCM@28221|Deltaproteobacteria,2Z2UB@29|Myxococcales 28221|Deltaproteobacteria C 4TM region of pyridine nucleotide transhydrogenase, mitoch - - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB_4TM k59_1647677_2 1121403.AUCV01000007_gene1233 6.03e-52 176.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,42NHS@68525|delta/epsilon subdivisions,2WJHI@28221|Deltaproteobacteria,2MIF6@213118|Desulfobacterales 28221|Deltaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane - - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_1070446_1 639030.JHVA01000001_gene166 9.35e-19 93.6 COG0760@1|root,COG0760@2|Bacteria,3Y3BW@57723|Acidobacteria,2JIP1@204432|Acidobacteriia 204432|Acidobacteriia O Peptidylprolyl isomerase - - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,Rotamase_3,SurA_N_3 k59_756269_1 1229909.NSED_05460 2.43e-127 375.0 COG1884@1|root,arCOG04232@2157|Archaea,41SBW@651137|Thaumarchaeota 651137|Thaumarchaeota I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_659933_1 1158762.KB898045_gene479 0.000724 41.6 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1WX60@135613|Chromatiales 135613|Chromatiales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_659933_2 1123368.AUIS01000005_gene292 2.57e-21 90.9 COG1418@1|root,COG1418@2|Bacteria,1RH6M@1224|Proteobacteria,1S81F@1236|Gammaproteobacteria,2NCJD@225057|Acidithiobacillales 225057|Acidithiobacillales S mRNA catabolic process - - - - - - - - - - - - - k59_132181_2 498211.CJA_2145 4.86e-18 78.2 2EH3I@1|root,33AVI@2|Bacteria,1NPJN@1224|Proteobacteria,1SJ2A@1236|Gammaproteobacteria,1FIF7@10|Cellvibrio 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1440787_1 765911.Thivi_1617 2.19e-48 176.0 COG1409@1|root,COG1409@2|Bacteria 2|Bacteria S acid phosphatase activity - - - - - - - - - - - - CBM_6,F5_F8_type_C,Glyco_hydro_92,Metallophos,PA14 k59_1231342_1 517418.Ctha_0993 7.7e-18 85.1 COG0697@1|root,COG0697@2|Bacteria 2|Bacteria EG spore germination cnrT - - - - - - - - - - - EamA k59_1231342_2 426117.M446_2978 5.92e-44 154.0 COG0421@1|root,COG0421@2|Bacteria,1QUUH@1224|Proteobacteria,2TW88@28211|Alphaproteobacteria,1JTH8@119045|Methylobacteriaceae 28211|Alphaproteobacteria E Spermidine synthase speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_1231342_3 1333998.M2A_1447 6.9e-70 222.0 COG1028@1|root,COG1028@2|Bacteria,1MWGC@1224|Proteobacteria,2TSNX@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ short-chain dehydrogenase - - - - - - - - - - - - adh_short_C2 k59_1231342_4 882083.SacmaDRAFT_2599 2.25e-30 116.0 COG1028@1|root,COG1028@2|Bacteria,2GM6W@201174|Actinobacteria,4E97T@85010|Pseudonocardiales 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short,adh_short_C2 k59_659946_1 572480.Arnit_1440 8.36e-32 117.0 COG2010@1|root,COG2010@2|Bacteria,1NKKK@1224|Proteobacteria,42UAC@68525|delta/epsilon subdivisions,2YRSI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Haem-binding domain - - - - - - - - - - - - Haem_bd k59_659946_2 1207063.P24_06766 1.45e-07 51.6 COG0625@1|root,COG0625@2|Bacteria,1REDI@1224|Proteobacteria,2TR9W@28211|Alphaproteobacteria,2JRYS@204441|Rhodospirillales 204441|Rhodospirillales O Belongs to the GST superfamily - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N,GST_N_3 k59_756279_1 639283.Snov_3626 3.57e-47 171.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,3EYE2@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_1231347_1 857087.Metme_0352 2.42e-42 157.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1XEUV@135618|Methylococcales 135618|Methylococcales H TonB dependent receptor - - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_85198_1 36630.CADNFIAP00009651 5.8e-71 235.0 COG1012@1|root,KOG2450@2759|Eukaryota,38CDB@33154|Opisthokonta,3NW4N@4751|Fungi,3QJDB@4890|Ascomycota,20BUA@147545|Eurotiomycetes,3S6ZQ@5042|Eurotiales 4751|Fungi E Belongs to the aldehyde dehydrogenase family ALD2 GO:0001505,GO:0003674,GO:0003824,GO:0004028,GO:0004029,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006082,GO:0006520,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009308,GO:0009310,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019482,GO:0019483,GO:0019752,GO:0034641,GO:0042133,GO:0042136,GO:0042402,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 1.2.1.3,1.2.1.5 ko:K00128,ko:K00129 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00350,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00980,ko00981,ko00982,ko01100,ko01110,ko01120,ko01130,ko05204,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00350,map00360,map00380,map00410,map00561,map00620,map00625,map00903,map00980,map00981,map00982,map01100,map01110,map01120,map01130,map05204 M00135 R00264,R00631,R00710,R00711,R00904,R01752,R01986,R02536,R02537,R02549,R02678,R02695,R02697,R02940,R02957,R03283,R03300,R03302,R03869,R04065,R04506,R04882,R04883,R04888,R04889,R04891,R04892,R04903,R04996,R05050,R05237,R05238,R05286,R06366,R07104,R08146,R08282,R08283,R08307 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500,RC01735 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_502628_2 1380394.JADL01000008_gene3523 8.41e-15 71.6 COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,2TSX7@28211|Alphaproteobacteria,2JRUR@204441|Rhodospirillales 204441|Rhodospirillales G Class II Aldolase and Adducin N-terminal domain - - 4.1.1.104 ko:K22130 - - - - ko00000,ko01000 - - - Aldolase_II k59_178850_2 85643.Tmz1t_0536 2.4e-18 83.6 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2VJEC@28216|Betaproteobacteria,2KU6S@206389|Rhodocyclales 206389|Rhodocyclales P Molybdenum ABC transporter periplasmic molybdate-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_1171863_1 1385515.N791_14835 6e-29 120.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1X3AY@135614|Xanthomonadales 135614|Xanthomonadales T Chemotaxis protein histidine kinase and related kinases pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_235055_1 1229909.NSED_06525 2.34e-146 418.0 COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota 651137|Thaumarchaeota T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,dCache_1 k59_1288593_2 472759.Nhal_3799 6.75e-27 105.0 COG0730@1|root,COG0730@2|Bacteria,1R712@1224|Proteobacteria,1S6UI@1236|Gammaproteobacteria,1WXAK@135613|Chromatiales 135613|Chromatiales S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_914911_1 403833.Pmob_1202 5.4e-93 288.0 COG0128@1|root,COG0128@2|Bacteria,2GCCE@200918|Thermotogae 200918|Thermotogae E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM0345 EPSP_synthase k59_340397_1 1122925.KB895382_gene3711 4.27e-29 119.0 COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,4H9Q8@91061|Bacilli,26RNE@186822|Paenibacillaceae 91061|Bacilli D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_133521_1 517417.Cpar_0333 1.19e-77 249.0 COG2170@1|root,COG2170@2|Bacteria,1FEUU@1090|Chlorobi 1090|Chlorobi S ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity - - - - - - - - - - - - - k59_914918_1 205918.Psyr_3617 1.47e-37 135.0 COG0500@1|root,COG0500@2|Bacteria,1RAE4@1224|Proteobacteria,1S0RC@1236|Gammaproteobacteria,1Z7T9@136849|Pseudomonas syringae group 1236|Gammaproteobacteria J thiopurine S-methyltransferase activity tpm GO:0003674,GO:0003824,GO:0008119,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008757,GO:0010035,GO:0010038,GO:0016740,GO:0016741,GO:0032259,GO:0042221,GO:0046690,GO:0050896 2.1.1.67 ko:K00569 ko00983,map00983 - R08236,R08239,R08246 RC00003,RC00980,RC02277 ko00000,ko00001,ko01000 - - - TPMT k59_178868_1 1121035.AUCH01000002_gene1673 4.55e-43 154.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,2KUWF@206389|Rhodocyclales 206389|Rhodocyclales O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1123556_1 395493.BegalDRAFT_2781 1.25e-115 337.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,1RNWH@1236|Gammaproteobacteria,460MF@72273|Thiotrichales 72273|Thiotrichales T Transcriptional regulatory protein, C terminal - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_1123556_2 1121448.DGI_2300 5.75e-80 255.0 COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,42SW9@68525|delta/epsilon subdivisions,2WPN3@28221|Deltaproteobacteria,2M9KZ@213115|Desulfovibrionales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1288615_1 1219035.NT2_09_01280 2.48e-33 121.0 COG5517@1|root,COG5517@2|Bacteria,1RDWV@1224|Proteobacteria,2U2PR@28211|Alphaproteobacteria,2KAJW@204457|Sphingomonadales 204457|Sphingomonadales Q Ring hydroxylating beta subunit - - - - - - - - - - - - Ring_hydroxyl_B k59_1288615_2 1394178.AWOO02000022_gene7183 1.44e-37 139.0 COG4638@1|root,COG4638@2|Bacteria,2GP4B@201174|Actinobacteria,4EQU8@85012|Streptosporangiales 201174|Actinobacteria P Ring hydroxylating alpha subunit (catalytic domain) - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_396760_1 768066.HELO_1354 1.19e-08 55.1 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1XH2S@135619|Oceanospirillales 135619|Oceanospirillales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_396760_3 1049564.TevJSym_ab01840 1.27e-19 84.0 COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1S94K@1236|Gammaproteobacteria,1J6Y3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG2927 DNA polymerase III, chi subunit holC GO:0005575,GO:0005622,GO:0005623,GO:0006275,GO:0008150,GO:0009314,GO:0009360,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032298,GO:0032991,GO:0042575,GO:0043846,GO:0043847,GO:0044424,GO:0044464,GO:0045740,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:0090329,GO:1902494,GO:1990234,GO:2000105,GO:2000112 2.7.7.7 ko:K02339 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_chi k59_666267_1 1280390.CBQR020000146_gene3728 5.22e-49 167.0 COG1014@1|root,COG1144@1|root,COG1014@2|Bacteria,COG1144@2|Bacteria,1TRFJ@1239|Firmicutes,4HBXC@91061|Bacilli,26T0J@186822|Paenibacillaceae 91061|Bacilli C ferredoxin porG - 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_7,POR k59_666267_2 877414.ATWA01000003_gene384 5.42e-11 61.2 COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,268S8@186813|unclassified Clostridiales 186801|Clostridia L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - HHH,RecR,Toprim_4 k59_1654009_1 472759.Nhal_1845 2e-60 210.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,LysM k59_507366_1 1335757.SPICUR_06695 1.05e-81 266.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WW1G@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1596235_2 317025.Tcr_0117 3.02e-24 102.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,45ZWG@72273|Thiotrichales 72273|Thiotrichales H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - Fer4_14,HemN_C,Radical_SAM k59_344811_2 765911.Thivi_3082 1.58e-12 67.4 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,1WWVX@135613|Chromatiales 135613|Chromatiales E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1076181_1 1144305.PMI02_01321 7.94e-16 85.1 COG3000@1|root,COG3000@2|Bacteria,1R646@1224|Proteobacteria,2U1PJ@28211|Alphaproteobacteria,2K0N0@204457|Sphingomonadales 28211|Alphaproteobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_1076181_2 83406.HDN1F_00350 1.6e-110 337.0 COG1680@1|root,COG1680@2|Bacteria,1R5MK@1224|Proteobacteria,1S015@1236|Gammaproteobacteria,1JBWQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1500776_2 1072685.IX83_02540 5.03e-44 156.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2VH04@28216|Betaproteobacteria,3T2NR@506|Alcaligenaceae 28216|Betaproteobacteria K transcriptional regulatory protein Btr fnr - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_450624_1 42345.XP_008793069.1 4.5e-13 75.9 COG0318@1|root,KOG1176@2759|Eukaryota,37M0N@33090|Viridiplantae,3G7ZG@35493|Streptophyta,3KT7R@4447|Liliopsida 35493|Streptophyta I AMP-binding enzyme - - - ko:K18660 ko00280,map00280 - R03383 RC00004,RC00137 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_1445263_1 439235.Dalk_5276 2.75e-63 213.0 2DUVJ@1|root,33SIS@2|Bacteria,1NUA7@1224|Proteobacteria,42YIB@68525|delta/epsilon subdivisions,2WU68@28221|Deltaproteobacteria,2MMP2@213118|Desulfobacterales 28221|Deltaproteobacteria S Parallel beta-helix repeats - - - - - - - - - - - - - k59_238522_2 413404.Rmag_0125 3.46e-55 185.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1J4ST@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0306 Phosphate sulphate permeases pitA GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_1076193_1 743299.Acife_0255 9.01e-58 189.0 COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,1RRR0@1236|Gammaproteobacteria,2NCB2@225057|Acidithiobacillales 225057|Acidithiobacillales O PFAM 20S proteasome, A and B subunits - - - ko:K07395 - - - - ko00000 - - - Proteasome k59_1386727_1 1121924.ATWH01000007_gene2010 6.17e-11 63.5 COG1024@1|root,COG1024@2|Bacteria,2GKJ6@201174|Actinobacteria 201174|Actinobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_1386727_2 485913.Krac_2597 1.71e-75 233.0 COG0778@1|root,COG0778@2|Bacteria 2|Bacteria C coenzyme F420-1:gamma-L-glutamate ligase activity - - - - - - - - - - - - Nitroreductase k59_14268_1 330214.NIDE0531 4.18e-49 166.0 COG0240@1|root,COG0240@2|Bacteria,3J0GP@40117|Nitrospirae 40117|Nitrospirae I NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_14268_2 99598.Cal7507_0822 4.8e-16 80.1 COG1691@1|root,COG1691@2|Bacteria,1G1W3@1117|Cyanobacteria,1HIMJ@1161|Nostocales 1117|Cyanobacteria S PFAM AIR carboxylase cpmA - - ko:K06898 - - - - ko00000 - - - AIRC k59_551461_1 1168065.DOK_17145 1.28e-24 100.0 COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,1RSEU@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the phosphoglycerate mutase family pgmA - 3.1.3.73 ko:K02226 ko00860,ko01100,map00860,map01100 M00122 R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_450639_1 483219.LILAB_03770 2.56e-155 469.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2YUB0@29|Myxococcales 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_1175020_1 1097668.BYI23_A024250 1.57e-09 53.1 COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,2VXPQ@28216|Betaproteobacteria,1KB36@119060|Burkholderiaceae 28216|Betaproteobacteria J Belongs to the bacterial ribosomal protein bL36 family rpmJ - - ko:K02919 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L36 k59_1175020_2 396588.Tgr7_2304 7.8e-99 299.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1WWJA@135613|Chromatiales 135613|Chromatiales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_507416_1 1038860.AXAP01000004_gene5251 4.08e-83 280.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2UQRW@28211|Alphaproteobacteria,3K2WX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T AAA ATPase domain - - - - - - - - - - - - AAA_16,Guanylate_cyc k59_450655_1 215803.DB30_5710 1.19e-24 97.4 COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,42P3W@68525|delta/epsilon subdivisions,2WNCT@28221|Deltaproteobacteria,2YYDE@29|Myxococcales 28221|Deltaproteobacteria M dTDP-4-dehydrorhamnose 3,5-epimerase rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_760544_1 1358423.N180_16440 0.000688 43.5 COG3071@1|root,COG3071@2|Bacteria,4NUU1@976|Bacteroidetes,1IY1A@117747|Sphingobacteriia 976|Bacteroidetes H Tetratricopeptide repeat - - - - - - - - - - - - TPR_17,TPR_8 k59_760544_2 395961.Cyan7425_0438 6.28e-20 84.7 COG3791@1|root,COG3791@2|Bacteria,1GAQM@1117|Cyanobacteria 1117|Cyanobacteria S Glutathione-dependent formaldehyde-activating - - - - - - - - - - - - GFA k59_238552_1 926556.Echvi_2202 2.09e-26 106.0 COG0115@1|root,COG0115@2|Bacteria,4NEJY@976|Bacteroidetes,47M72@768503|Cytophagia 976|Bacteroidetes EH Branched-chain amino acid aminotransferase ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_238552_2 504472.Slin_1099 4.36e-44 150.0 COG2096@1|root,COG2096@2|Bacteria,4NFHQ@976|Bacteroidetes,47P8Y@768503|Cytophagia 976|Bacteroidetes S PFAM Cobalamin adenosyltransferase yvqK - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_603939_1 1207063.P24_02356 5.48e-09 64.7 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2TQRC@28211|Alphaproteobacteria,2JQ0M@204441|Rhodospirillales 204441|Rhodospirillales M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_1445300_1 1121935.AQXX01000144_gene4524 3.53e-05 47.8 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,1S9Z9@1236|Gammaproteobacteria,1XKPZ@135619|Oceanospirillales 135619|Oceanospirillales C cytochrome c5 - - - - - - - - - - - - Cytochrome_CBB3 k59_551489_1 1266925.JHVX01000008_gene356 1.68e-19 84.0 COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,2VSI6@28216|Betaproteobacteria,3738X@32003|Nitrosomonadales 28216|Betaproteobacteria K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_551489_2 983545.Glaag_3084 3.62e-56 186.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,466CJ@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0382 AIRS,AIRS_C k59_919783_1 1121937.AUHJ01000010_gene1707 2.37e-68 219.0 COG2159@1|root,COG2159@2|Bacteria,1PZ2I@1224|Proteobacteria,1S1Y9@1236|Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase of the TIM-barrel fold - - - - - - - - - - - - Amidohydro_2 k59_603943_1 391937.NA2_15469 1.02e-142 410.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TT67@28211|Alphaproteobacteria,43IB2@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily adhC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0008150,GO:0008152,GO:0015945,GO:0034308,GO:0044281,GO:0044424,GO:0044464,GO:0071704,GO:1901615 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_507449_1 1565129.JSFF01000002_gene3568 2.18e-38 149.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,2Q8WX@267890|Shewanellaceae 1236|Gammaproteobacteria M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0009636,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042221,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0050896,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:1901264 - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - iG2583_1286.G2583_0058 OstA,OstA_C k59_396819_1 1265503.KB905164_gene1781 4.91e-115 353.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,2Q6Y5@267889|Colwelliaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_760560_2 1173021.ALWA01000027_gene2647 8.58e-23 96.7 COG0625@1|root,COG0625@2|Bacteria,1G34I@1117|Cyanobacteria 1117|Cyanobacteria O Belongs to the GST superfamily - - 2.5.1.18 ko:K00799,ko:K11209 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N,GST_N_3 k59_1175053_1 1499967.BAYZ01000030_gene1167 1.05e-17 87.8 COG1520@1|root,COG1572@1|root,COG3210@1|root,COG1520@2|Bacteria,COG1572@2|Bacteria,COG3210@2|Bacteria,2NRGG@2323|unclassified Bacteria 2|Bacteria U Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - 1.1.2.6 ko:K05889,ko:K12678 - - R03136 - ko00000,ko01000,ko02000,ko02044 1.B.12.1.1,1.B.12.1.3 - - CARDB,Cadherin-like,Calx-beta,Chlam_PMP,Flg_new,Lectin_legB,PQQ_2,SLH k59_137808_1 1229909.NSED_01325 2.41e-116 352.0 COG1009@1|root,arCOG01539@2157|Archaea,41SC4@651137|Thaumarchaeota 651137|Thaumarchaeota C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_970438_1 582744.Msip34_0030 3.58e-54 181.0 COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,2KKU7@206350|Nitrosomonadales 206350|Nitrosomonadales C PFAM oxidoreductase FAD NAD(P)-binding domain protein - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_1295005_2 768706.Desor_2994 1.41e-155 450.0 COG0183@1|root,COG0183@2|Bacteria,1TT8U@1239|Firmicutes,24AD9@186801|Clostridia 186801|Clostridia I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - DUF35_N,Thiolase_C,Thiolase_N,ketoacyl-synt k59_1295005_3 1265310.CCBD010000034_gene2095 2.45e-17 80.9 COG1545@1|root,COG1545@2|Bacteria,2IFQP@201174|Actinobacteria,238SF@1762|Mycobacteriaceae 201174|Actinobacteria S nucleic-acid-binding protein containing a Zn-ribbon - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_921219_1 639030.JHVA01000001_gene3765 0.000181 44.7 COG0673@1|root,COG0673@2|Bacteria,3Y486@57723|Acidobacteria,2JHJI@204432|Acidobacteriia 204432|Acidobacteriia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_921219_2 1162668.LFE_2226 8.27e-28 112.0 COG0677@1|root,COG0677@2|Bacteria,3J0HI@40117|Nitrospirae 40117|Nitrospirae C Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.136 ko:K02474,ko:K13015 ko00520,map00520 - R00421,R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_866790_2 1415780.JPOG01000001_gene2897 2.07e-62 207.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,1X587@135614|Xanthomonadales 135614|Xanthomonadales S Succinylglutamate desuccinylase / Aspartoacylase family - - - - - - - - - - - - AstE_AspA k59_552799_1 861299.J421_2559 4.54e-29 115.0 COG0682@1|root,COG0682@2|Bacteria,1ZSYY@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_239803_1 710393.HSUHS1_1187 2.01e-29 120.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2YMZG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB k59_1655883_1 1150469.RSPPHO_02663 1.3e-87 270.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2TRUG@28211|Alphaproteobacteria,2JQ3T@204441|Rhodospirillales 204441|Rhodospirillales M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_1655883_2 313589.JNB_00635 4.96e-11 67.8 COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4FEIE@85021|Intrasporangiaceae 201174|Actinobacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iNJ661.Rv2155c AlaDh_PNT_C,Mur_ligase_C,Mur_ligase_M k59_1537725_1 998674.ATTE01000001_gene2664 3.39e-78 248.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,4600M@72273|Thiotrichales 72273|Thiotrichales O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1537725_2 1034943.BN1094_01660 2.05e-11 59.7 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,1JEPU@118969|Legionellales 118969|Legionellales O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_92808_1 1192034.CAP_5039 1.73e-108 321.0 COG1125@1|root,COG1125@2|Bacteria,1QTUC@1224|Proteobacteria,42MXW@68525|delta/epsilon subdivisions,2WK94@28221|Deltaproteobacteria,2YWE8@29|Myxococcales 28221|Deltaproteobacteria E ABC transporter - - - ko:K05847 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - ABC_tran,CBS k59_970455_1 870187.Thini_0288 4.15e-31 118.0 COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,460TW@72273|Thiotrichales 72273|Thiotrichales S High frequency lysogenization protein hflD homolog hflD - - ko:K07153 - - - - ko00000 - - - DUF489 k59_14806_1 637730.C8XUR7_9CAUD 4.96e-14 80.1 4QBAK@10239|Viruses,4QY34@35237|dsDNA viruses no RNA stage,4QQBQ@28883|Caudovirales,4QIQI@10662|Myoviridae 10662|Myoviridae S Bacteriophage T4-like capsid assembly protein (Gp20) - GO:0005575,GO:0019012 - - - - - - - - - - - k59_509246_1 1381123.AYOD01000011_gene2886 2.74e-21 97.4 COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,2TSDU@28211|Alphaproteobacteria,43HJT@69277|Phyllobacteriaceae 28211|Alphaproteobacteria V multidrug norM - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_921237_1 436308.Nmar_1769 4.04e-70 226.0 COG0531@1|root,arCOG00009@2157|Archaea,41SXX@651137|Thaumarchaeota 651137|Thaumarchaeota E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_452436_1 1123355.JHYO01000036_gene619 1.37e-56 186.0 COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TRQ7@28211|Alphaproteobacteria,370IF@31993|Methylocystaceae 28211|Alphaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_452436_2 377629.TERTU_1934 1.54e-29 116.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,2PMG7@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria H HemN C-terminal domain hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.98.3 ko:K02495 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R06895 RC00884 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_3134,iZ_1308.Z5403 HemN_C,Radical_SAM k59_1023011_1 1123399.AQVE01000007_gene1165 4.11e-72 231.0 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,45ZRD@72273|Thiotrichales 72273|Thiotrichales H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_1077771_1 309807.SRU_1985 4.24e-16 84.7 COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,1FJR9@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp k59_711881_1 1283300.ATXB01000001_gene797 2.62e-75 243.0 COG0119@1|root,COG0119@2|Bacteria,1R7YB@1224|Proteobacteria,1RQB8@1236|Gammaproteobacteria,1XEJD@135618|Methylococcales 135618|Methylococcales E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.1.182 ko:K09011 ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230 M00535 R07399 RC00004,RC01205 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_346236_1 436308.Nmar_1725 4.4e-57 186.0 COG0301@1|root,arCOG00038@2157|Archaea,41T1A@651137|Thaumarchaeota 651137|Thaumarchaeota H Thiamine biosynthesis protein (ThiI) - - - - - - - - - - - - DUF814,ThiI k59_509270_1 177437.HRM2_42010 3.06e-18 79.7 COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2MHUF@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_509270_2 933262.AXAM01000083_gene767 1.76e-21 85.1 2CCKF@1|root,334IH@2|Bacteria,1NDED@1224|Proteobacteria,42VZE@68525|delta/epsilon subdivisions,2WRMN@28221|Deltaproteobacteria,2MM08@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1023016_1 96561.Dole_1326 1.15e-62 214.0 COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,42NVI@68525|delta/epsilon subdivisions,2WJTD@28221|Deltaproteobacteria,2MMNF@213118|Desulfobacterales 28221|Deltaproteobacteria EH PFAM thiamine pyrophosphate protein domain protein TPP-binding - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_970479_1 1499967.BAYZ01000099_gene4398 4.21e-29 115.0 COG1943@1|root,COG1943@2|Bacteria,2NQ84@2323|unclassified Bacteria 2|Bacteria L Transposase IS200 like - - - - - - - - - - - - Bac_DnaA_C,Y1_Tnp k59_1238656_1 1370121.AUWS01000081_gene821 1.1e-39 138.0 COG1335@1|root,COG1335@2|Bacteria,2ID48@201174|Actinobacteria,237YC@1762|Mycobacteriaceae 201174|Actinobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_1176232_1 374847.Kcr_0230 3.38e-98 296.0 COG0136@1|root,arCOG00494@2157|Archaea 2157|Archaea E aspartate-semialdehyde dehydrogenase - - 1.2.1.12,1.2.1.59 ko:K00134,ko:K00150 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061,R01063 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_452470_1 1088869.GMO_09320 7.65e-08 56.6 COG4208@1|root,COG4208@2|Bacteria,1MV8X@1224|Proteobacteria,2TQR8@28211|Alphaproteobacteria,2JP94@204441|Rhodospirillales 204441|Rhodospirillales P sulfate transport system, permease cysW - - ko:K02047 ko00920,ko02010,map00920,map02010 M00185 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3 - - BPD_transp_1 k59_452470_2 360911.EAT1b_1934 1.37e-14 77.4 COG1840@1|root,COG1840@2|Bacteria,1TSKP@1239|Firmicutes,4HBH2@91061|Bacilli,3WF4A@539002|Bacillales incertae sedis 91061|Bacilli P Bacterial extracellular solute-binding protein - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6,SBP_bac_8 k59_1178272_1 1144310.PMI07_003681 5.01e-91 275.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,4BDWB@82115|Rhizobiaceae 28211|Alphaproteobacteria E Cobalamin-independent synthase, Catalytic domain metE - 2.1.1.14,4.4.1.23 ko:K00549,ko:K22363 ko00270,ko00450,ko00625,ko01100,ko01110,ko01230,map00270,map00450,map00625,map01100,map01110,map01230 M00017 R04405,R09365,R11897,R11899 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_2 k59_1178275_2 1042377.AFPJ01000028_gene2159 7.8e-09 56.6 2BWPY@1|root,2Z8BI@2|Bacteria,1QHHB@1224|Proteobacteria,1RP8D@1236|Gammaproteobacteria,4657P@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_671150_1 1210908.HSB1_34490 2.24e-19 92.0 COG4948@1|root,arCOG01168@2157|Archaea,2XTSG@28890|Euryarchaeota,23SSG@183963|Halobacteria 183963|Halobacteria M COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily - - 4.2.1.6 ko:K01684 ko00052,ko01100,ko01120,map00052,map01100,map01120 M00552 R03033 RC00543 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_1241015_1 391625.PPSIR1_03323 3.51e-67 215.0 COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,43AEV@68525|delta/epsilon subdivisions,2X5YA@28221|Deltaproteobacteria,2YUMQ@29|Myxococcales 28221|Deltaproteobacteria S Nitronate monooxygenase - - 1.13.12.16,1.3.1.9 ko:K00459,ko:K02371 ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212 M00083 R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076,RC02541,RC02759 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO k59_1539696_1 479434.Sthe_1416 9.18e-17 78.2 COG2332@1|root,COG2332@2|Bacteria,2G7CS@200795|Chloroflexi,27YD4@189775|Thermomicrobia 189775|Thermomicrobia O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH - - - ko:K02197 - - - - ko00000 - - - CcmE k59_1505767_1 1123279.ATUS01000001_gene1384 1.46e-152 447.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1J4UV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iUTI89_1310.UTI89_C0210 HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_606932_1 317936.Nos7107_0087 3.24e-10 66.2 COG2199@1|root,COG2200@1|root,COG2203@1|root,COG2200@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1GQ5I@1117|Cyanobacteria,1HN0Q@1161|Nostocales 1117|Cyanobacteria T Diguanylate cyclase - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - CBS,EAL,GAF,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_1659078_1 1357272.AVEO02000151_gene1444 1.74e-12 64.7 COG5626@1|root,COG5626@2|Bacteria,1N8QB@1224|Proteobacteria,1SDJI@1236|Gammaproteobacteria,1Z86X@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S Protein of unknown function (DUF2288) - - - - - - - - - - - - DUF2288 k59_868822_1 1121940.AUDZ01000013_gene640 1.11e-43 154.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1XI4U@135619|Oceanospirillales 135619|Oceanospirillales L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_606937_1 572477.Alvin_2369 2.47e-74 251.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1241027_1 572477.Alvin_2064 4.07e-66 221.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales 135613|Chromatiales O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_1659087_1 498211.CJA_0765 5.3e-49 174.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1FGMX@10|Cellvibrio 1236|Gammaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_1659087_2 1049564.TevJSym_ac02040 2.16e-09 55.5 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,1S61A@1236|Gammaproteobacteria,1J67Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Yqey-like protein lporfX - - ko:K09117 - - - - ko00000 - - - YqeY k59_454880_1 765420.OSCT_0127 1.53e-82 263.0 COG0423@1|root,COG0423@2|Bacteria,2G62M@200795|Chloroflexi,376EQ@32061|Chloroflexia 32061|Chloroflexia J Catalyzes the attachment of glycine to tRNA(Gly) glyQS - 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b k59_972747_1 886293.Sinac_4737 6.52e-74 240.0 COG1164@1|root,COG1164@2|Bacteria,2IWWZ@203682|Planctomycetes 203682|Planctomycetes E oligoendopeptidase F - - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_1659111_1 1379270.AUXF01000001_gene2678 1.08e-52 176.0 COG1234@1|root,COG1234@2|Bacteria,1ZTG7@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_141806_1 1255043.TVNIR_1350 5.45e-44 160.0 28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria,1S1M3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S phosphoenolpyruvate carboxykinase (diphosphate) activity - - 4.1.1.38 ko:K20370 ko00620,ko01100,map00620,map01100 - R00346 RC02741 ko00000,ko00001,ko01000 - - - - k59_606953_1 330214.NIDE1577 3.4e-112 327.0 COG0777@1|root,COG0777@2|Bacteria,3J0CK@40117|Nitrospirae 40117|Nitrospirae I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1505812_1 404589.Anae109_0681 2.11e-80 251.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NSM@68525|delta/epsilon subdivisions,2WJXQ@28221|Deltaproteobacteria,2YXY8@29|Myxococcales 28221|Deltaproteobacteria V AAA domain, putative AbiEii toxin, Type IV TA system pilH - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_399959_2 706587.Desti_3807 2.1e-50 180.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2MR9G@213462|Syntrophobacterales 28221|Deltaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdA1 - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD k59_1505825_1 314278.NB231_09768 3.86e-125 376.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1WXVV@135613|Chromatiales 135613|Chromatiales J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_763753_1 1121439.dsat_2345 5.46e-25 101.0 COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,42R55@68525|delta/epsilon subdivisions,2WN4E@28221|Deltaproteobacteria,2M82H@213115|Desulfovibrionales 28221|Deltaproteobacteria S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_1505831_2 631362.Thi970DRAFT_00091 7.27e-66 212.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1WXI6@135613|Chromatiales 135613|Chromatiales F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_349180_1 1408418.JNJH01000044_gene2658 2.04e-87 268.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,2JQ78@204441|Rhodospirillales 204441|Rhodospirillales E Aminotransferase class-V - - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_1448543_2 502025.Hoch_5332 1.67e-59 192.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria,2YZAP@29|Myxococcales 28221|Deltaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_1080696_1 1463881.KL591017_gene3380 7.51e-25 102.0 COG5486@1|root,COG5486@2|Bacteria,2IAYZ@201174|Actinobacteria 201174|Actinobacteria S Predicted metal-binding integral membrane protein (DUF2182) - - - - - - - - - - - - DUF2182 k59_1080696_2 266835.14024522 5.48e-05 44.3 COG5588@1|root,COG5588@2|Bacteria,1MWK3@1224|Proteobacteria,2TQPP@28211|Alphaproteobacteria,43ITC@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1326) - - - - - - - - - - - - DUF1326 k59_1298229_1 1227487.C474_13091 2.27e-17 85.9 COG3408@1|root,arCOG03287@2157|Archaea,2Y33S@28890|Euryarchaeota,23Z12@183963|Halobacteria 183963|Halobacteria G Trehalase - - - - - - - - - - - - Trehalase k59_512460_1 903818.KI912268_gene924 4.5e-32 128.0 COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria 2|Bacteria I CoA carboxylase activity - - - - - - - - - - - - ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans k59_556207_2 27337.EGY18883 0.000139 45.1 COG0493@1|root,KOG1800@2759|Eukaryota,38D89@33154|Opisthokonta,3NUPV@4751|Fungi,3QKPF@4890|Ascomycota,213KI@147550|Sordariomycetes,1EZWR@1028384|Glomerellales 4751|Fungi C NADPH adrenodoxin oxidoreductase, mitochondrial ARH1 GO:0000166,GO:0003674,GO:0003824,GO:0004324,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006091,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006790,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008860,GO:0009058,GO:0009108,GO:0009987,GO:0015039,GO:0015980,GO:0016020,GO:0016043,GO:0016226,GO:0016491,GO:0016730,GO:0016731,GO:0019725,GO:0019866,GO:0022607,GO:0022900,GO:0022904,GO:0030003,GO:0031090,GO:0031163,GO:0031966,GO:0031967,GO:0031975,GO:0036094,GO:0042180,GO:0042181,GO:0042592,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044571,GO:0045333,GO:0046916,GO:0048037,GO:0048878,GO:0050660,GO:0050662,GO:0050801,GO:0051186,GO:0051188,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:0098771,GO:1901265,GO:1901363,GO:1901576,GO:1901661,GO:1901663 1.18.1.6 ko:K18914 - - - - ko00000,ko01000,ko03029 - - - Pyr_redox_2 k59_1660670_2 349163.Acry_0213 2.57e-38 139.0 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2TVBT@28211|Alphaproteobacteria,2JRQJ@204441|Rhodospirillales 204441|Rhodospirillales O once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran k59_715368_1 977880.RALTA_A1156 9.99e-21 96.3 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,1JZT5@119060|Burkholderiaceae 28216|Betaproteobacteria S Competence protein ComEC comA - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_1390933_2 326427.Cagg_2354 8.88e-45 158.0 COG1190@1|root,COG1190@2|Bacteria,2G65Z@200795|Chloroflexi,3754Z@32061|Chloroflexia 32061|Chloroflexia J PFAM tRNA synthetase class II (G H P and S) lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_925251_1 555387.C7BVB4_9CAUD 1.01e-06 55.1 4QGK4@10239|Viruses,4QYDG@35237|dsDNA viruses no RNA stage,4QUFN@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_455963_1 936573.HMPREF1147_0417 2.44e-17 84.0 COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,4H420@909932|Negativicutes 909932|Negativicutes J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_829969_1 1232666.JANE01000045_gene1180 1.37e-14 76.3 COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,4H9PH@91061|Bacilli,4GXHW@90964|Staphylococcaceae 91061|Bacilli E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - iYO844.BSU23070 2-Hacid_dh,2-Hacid_dh_C,ACT k59_1133820_1 317619.ANKN01000149_gene1477 0.000267 48.9 COG2755@1|root,COG2755@2|Bacteria,1GJ2K@1117|Cyanobacteria,1MPGZ@1212|Prochloraceae 1117|Cyanobacteria E lipolytic protein G-D-S-L family - - - - - - - - - - - - - k59_1390937_1 1000565.METUNv1_02311 4.2e-96 304.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,2KV4W@206389|Rhodocyclales 206389|Rhodocyclales I AcyL-CoA dehydrogenase fadE - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N,DUF1974 k59_715377_1 1341151.ASZU01000030_gene2732 3.22e-07 48.1 29SZF@1|root,30E5V@2|Bacteria,1UC5P@1239|Firmicutes,4INN3@91061|Bacilli,27D57@186824|Thermoactinomycetaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_764838_2 187272.Mlg_2622 5.46e-184 525.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales 135613|Chromatiales P PFAM TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_715378_1 443598.AUFA01000028_gene7123 4.86e-18 81.6 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TT8N@28211|Alphaproteobacteria,3JSX4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E ATPases associated with a variety of cellular activities MA20_42585 - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_715378_2 1125863.JAFN01000001_gene166 1.99e-97 295.0 COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,42ND9@68525|delta/epsilon subdivisions,2WK5F@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Periplasmic binding protein - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1242110_1 1173025.GEI7407_0433 3.24e-05 52.8 COG3209@1|root,COG3210@1|root,COG3240@1|root,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3240@2|Bacteria 2|Bacteria I lipase activity - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - CHU_C,Calx-beta,Lipase_GDSL,RHS_repeat k59_1600328_1 314285.KT71_06909 2.01e-35 129.0 2C852@1|root,32YB2@2|Bacteria,1RH28@1224|Proteobacteria,1TH5C@1236|Gammaproteobacteria,1J8I3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4136) - - - - - - - - - - - - DUF4136 k59_16724_1 502025.Hoch_3329 4.43e-08 53.9 COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria,2YWME@29|Myxococcales 28221|Deltaproteobacteria L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD ku - - ko:K10979 ko03450,map03450 - - - ko00000,ko00001,ko03400 - - - Ku k59_16724_2 404589.Anae109_0939 6e-52 182.0 COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,42U99@68525|delta/epsilon subdivisions,2WQ5W@28221|Deltaproteobacteria,2YWMR@29|Myxococcales 28221|Deltaproteobacteria L ATP dependent DNA ligase domain protein - - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N k59_1335503_1 1210884.HG799464_gene10885 7.24e-39 146.0 COG1233@1|root,COG1233@2|Bacteria,2IX17@203682|Planctomycetes 203682|Planctomycetes Q FAD dependent oxidoreductase - - - - - - - - - - - - Amino_oxidase k59_1335503_2 925775.XVE_3057 4.16e-22 95.1 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1X32A@135614|Xanthomonadales 135614|Xanthomonadales I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation pcaF - 2.3.1.174 ko:K07823 ko00362,ko01120,map00362,map01120 - R00829 RC00004,RC00326 ko00000,ko00001,ko01000 - - - Thiolase_C,Thiolase_N k59_715394_1 1046724.KB889880_gene1925 2.3e-24 98.6 COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,468BK@72275|Alteromonadaceae 1236|Gammaproteobacteria S Modulates RecA activity recX GO:0003674,GO:0005488,GO:0005515,GO:0006282,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0071496,GO:0080090,GO:0080134,GO:0080135,GO:0098772,GO:2001020 - ko:K03565 - - - - ko00000,ko03400 - - - RecX k59_400947_1 118173.KB235914_gene1772 4.5e-06 54.3 COG1020@1|root,COG1020@2|Bacteria,1G2QF@1117|Cyanobacteria,1HD5R@1150|Oscillatoriales 1117|Cyanobacteria Q Condensation domain - - - - - - - - - - - - Condensation k59_764863_2 293613.A1E_03845 0.000425 43.5 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria,47F2C@766|Rickettsiales 766|Rickettsiales O COG0330 Membrane protease subunits, stomatin prohibitin homologs hflC1 - - - - - - - - - - - Band_7,Band_7_C k59_830019_1 318996.AXAZ01000032_gene3403 4.12e-19 89.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,3JRJI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - DUF4118,HATPase_c,HisKA,PAS_3,PAS_9 k59_830019_2 935845.JADQ01000010_gene3057 9.97e-05 45.8 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,4HVYH@91061|Bacilli,26S67@186822|Paenibacillaceae 91061|Bacilli T response regulator - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg k59_350358_1 436308.Nmar_1601 6.08e-13 65.5 COG2811@1|root,arCOG03363@2157|Archaea,41TA7@651137|Thaumarchaeota 651137|Thaumarchaeota C H subunit - - - ko:K02107 ko00190,map00190 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - - k59_243323_1 1211643.K4JQL7_9CAUD 2.62e-16 85.1 4QAQ9@10239|Viruses,4QUYQ@35237|dsDNA viruses no RNA stage,4QPTV@28883|Caudovirales,4QKRS@10699|Siphoviridae 10699|Siphoviridae S Putative phage tail protein - GO:0005575,GO:0008150,GO:0016032,GO:0018995,GO:0019012,GO:0019058,GO:0019062,GO:0022610,GO:0030430,GO:0033643,GO:0033646,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044403,GO:0044406,GO:0044419,GO:0044650,GO:0051704 - - - - - - - - - - - k59_556263_1 1095769.CAHF01000021_gene938 8.19e-101 299.0 COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2VNEK@28216|Betaproteobacteria,477GY@75682|Oxalobacteraceae 28216|Betaproteobacteria P ABC-type sugar transport system, permease component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_514047_1 1229780.BN381_70071 7.9e-46 154.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4,Polysacc_synt_3,Polysacc_synt_C k59_514047_2 1313172.YM304_38750 3.63e-58 191.0 COG2267@1|root,COG2267@2|Bacteria 2|Bacteria I carboxylic ester hydrolase activity - - - - - - - - - - - - Hydrolase_4 k59_400966_1 706587.Desti_1274 1.4e-09 63.5 COG2030@1|root,COG2030@2|Bacteria,1RC8D@1224|Proteobacteria,42R40@68525|delta/epsilon subdivisions,2WMNV@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM MaoC like domain - - - - - - - - - - - - MaoC_dehydrat_N,MaoC_dehydratas k59_764885_1 1229909.NSED_09780 4.79e-18 80.5 COG5491@1|root,arCOG00452@2157|Archaea,41SYC@651137|Thaumarchaeota 651137|Thaumarchaeota D conserved protein implicated in secretion - - - - - - - - - - - - - k59_1540745_1 944480.ATUV01000001_gene1162 5.28e-36 141.0 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2WJGZ@28221|Deltaproteobacteria,2M708@213113|Desulfurellales 28221|Deltaproteobacteria S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_1390985_1 706587.Desti_4022 2.16e-13 69.3 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RCI@68525|delta/epsilon subdivisions,2WMYC@28221|Deltaproteobacteria,2MQGX@213462|Syntrophobacterales 28221|Deltaproteobacteria C Electron transfer flavoprotein domain etfB - - ko:K03521 - - - - ko00000 - - - ETF k59_1390985_2 153721.MYP_1941 2.66e-49 165.0 COG1611@1|root,COG1611@2|Bacteria,4NF20@976|Bacteroidetes,47KCT@768503|Cytophagia 976|Bacteroidetes S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_1540752_1 1380394.JADL01000012_gene856 4.46e-105 323.0 28JZQ@1|root,2Z9PN@2|Bacteria,1N2WN@1224|Proteobacteria,2U0QD@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_870010_2 1041139.KB902613_gene284 1.33e-17 76.6 COG5476@1|root,COG5476@2|Bacteria,1R1ER@1224|Proteobacteria,2TQK8@28211|Alphaproteobacteria,4BFX5@82115|Rhizobiaceae 28211|Alphaproteobacteria S MlrC C-terminus - - - - - - - - - - - - DUF1485,MlrC_C k59_243343_1 1429916.X566_09575 1.76e-82 253.0 COG1028@1|root,COG1028@2|Bacteria,1QTUD@1224|Proteobacteria,2TWT3@28211|Alphaproteobacteria,3K6NW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1507496_1 67373.JOBF01000001_gene5972 6.24e-22 101.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2GMFD@201174|Actinobacteria 201174|Actinobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_1299913_1 485913.Krac_9972 1.39e-37 144.0 COG0515@1|root,COG0515@2|Bacteria,2G7ZS@200795|Chloroflexi 485913.Krac_9972|- KLT Serine threonine protein kinase - - - - - - - - - - - - - k59_973954_2 411469.EUBHAL_00175 4.94e-29 113.0 COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,25VC7@186806|Eubacteriaceae 186801|Clostridia L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_870019_1 1458427.BAWN01000020_gene1241 2.29e-87 267.0 COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,2VV80@28216|Betaproteobacteria,4AGJ4@80864|Comamonadaceae 28216|Betaproteobacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_1299920_1 1125973.JNLC01000011_gene480 1.74e-76 250.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,3JXXJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E FAD dependent oxidoreductase Sardh GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006575,GO:0006576,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008480,GO:0009056,GO:0009063,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019695,GO:0019752,GO:0019842,GO:0031406,GO:0031974,GO:0033218,GO:0034641,GO:0035999,GO:0036094,GO:0042133,GO:0042135,GO:0042219,GO:0042402,GO:0042426,GO:0042558,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046483,GO:0046653,GO:0046997,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072341,GO:0097159,GO:0097164,GO:1901052,GO:1901053,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.5.3.19 ko:K19191 ko00760,ko01120,map00760,map01120 - R10102 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO,FAO_M,GCV_T,GCV_T_C k59_1105179_1 1266925.JHVX01000001_gene2509 3.02e-19 82.4 COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,2VVQJ@28216|Betaproteobacteria,373MD@32003|Nitrosomonadales 28216|Betaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsB - - ko:K05589 - - - - ko00000,ko03036 - - - DivIC k59_1105179_2 395493.BegalDRAFT_3015 1.91e-70 222.0 COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,460Q8@72273|Thiotrichales 72273|Thiotrichales I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - - IspD k59_1105179_3 218491.ECA3534 1.82e-58 186.0 COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1MS09@122277|Pectobacterium 1236|Gammaproteobacteria F Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008270,GO:0008685,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016849,GO:0030145,GO:0042180,GO:0042181,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.6.1.12 ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO3360 YgbB k59_1263718_1 1229909.NSED_09670 3.81e-102 311.0 COG0652@1|root,arCOG04767@2157|Archaea,41T0W@651137|Thaumarchaeota 651137|Thaumarchaeota O Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_582369_1 765911.Thivi_2619 2.35e-105 317.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,1WX6R@135613|Chromatiales 135613|Chromatiales E PFAM Aminotransferase class I and II - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_999650_1 1163617.SCD_n01692 1.23e-61 204.0 COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,2VM95@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF1015) - - - - - - - - - - - - DUF1015 k59_373660_1 1123072.AUDH01000001_gene2803 2.42e-85 268.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,2JQP4@204441|Rhodospirillales 204441|Rhodospirillales EQ Hydantoinase B/oxoprolinase - - - - - - - - - - - - Hydantoinase_B k59_1052857_1 1249627.D779_0440 4.02e-66 221.0 COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,1T2FP@1236|Gammaproteobacteria,1WWXW@135613|Chromatiales 135613|Chromatiales C PFAM 2Fe-2S iron-sulfur cluster binding domain - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2 k59_582372_1 2754.EH55_00105 3.7e-06 55.5 COG1319@1|root,COG1319@2|Bacteria,3TCD9@508458|Synergistetes 508458|Synergistetes C CO dehydrogenase flavoprotein C-terminal domain - - - - - - - - - - - - CO_deh_flav_C,FAD_binding_5 k59_162616_1 469618.FVAG_02846 1.17e-19 83.6 COG0198@1|root,COG0198@2|Bacteria,37AIF@32066|Fusobacteria 32066|Fusobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_162616_2 1162668.LFE_0893 1.8e-38 130.0 COG0093@1|root,COG0093@2|Bacteria,3J0JD@40117|Nitrospirae 40117|Nitrospirae J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_373664_2 1191523.MROS_0140 1.42e-25 108.0 COG0248@1|root,COG0248@2|Bacteria 2|Bacteria FP Ppx GppA phosphatase ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - HD,Ppx-GppA k59_216903_1 330214.NIDE3358 8.25e-20 93.6 COG1729@1|root,COG4372@1|root,COG1729@2|Bacteria,COG4372@2|Bacteria 2|Bacteria Q Transposase - - - ko:K01991,ko:K02557,ko:K07161,ko:K07484 ko02026,ko02030,ko02040,map02026,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1,1.B.18 - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,DUF3084,LZ_Tnp_IS66,TPR_6,zf-IS66 k59_1211615_1 1380394.JADL01000014_gene195 2.62e-88 265.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2U08R@28211|Alphaproteobacteria,2JUXU@204441|Rhodospirillales 204441|Rhodospirillales C 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - - Fer2_3,Fer4_17 k59_1211615_2 391616.OA238_c16270 8.44e-27 104.0 COG2128@1|root,COG2128@2|Bacteria,1N0RE@1224|Proteobacteria,2TQZK@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_947611_1 1121456.ATVA01000002_gene3194 4.93e-19 89.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,42R6I@68525|delta/epsilon subdivisions,2WN1K@28221|Deltaproteobacteria,2MBSJ@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM VacJ family lipoprotein - - - ko:K04754 - - - - ko00000 - - - MlaA k59_1052872_1 518766.Rmar_1913 1.97e-22 103.0 COG0457@1|root,COG0457@2|Bacteria,4PM61@976|Bacteroidetes,1FJ2G@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - - k59_111787_1 349124.Hhal_1195 2.59e-58 192.0 COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria 1236|Gammaproteobacteria G sugar kinase adoK - 2.7.1.20 ko:K00856 ko00230,ko01100,map00230,map01100 - R00185 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_1105209_1 335543.Sfum_2496 1.67e-38 137.0 COG2834@1|root,COG2834@2|Bacteria,1R5U8@1224|Proteobacteria,42MIS@68525|delta/epsilon subdivisions,2WMK7@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_111791_1 118005.AWNK01000005_gene1526 3.21e-47 166.0 COG1060@1|root,COG1060@2|Bacteria 2|Bacteria H 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity mqnE GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 2.5.1.120,2.5.1.77 ko:K11779,ko:K11780,ko:K11781,ko:K18285 ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120 M00378 R09396,R10667 RC00021,RC01381,RC03002,RC03007,RC03234 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3391 Radical_SAM k59_843841_2 330214.NIDE4114 3.12e-66 216.0 COG0440@1|root,COG0460@1|root,COG0440@2|Bacteria,COG0460@2|Bacteria,3J0G1@40117|Nitrospirae 40117|Nitrospirae E Homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_1418298_1 998674.ATTE01000001_gene2402 2.22e-27 109.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,45ZWY@72273|Thiotrichales 72273|Thiotrichales Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_1418298_2 991905.SL003B_0824 1.22e-85 266.0 COG4665@1|root,COG4665@2|Bacteria,1R4T4@1224|Proteobacteria,2U2FK@28211|Alphaproteobacteria,4BREP@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - - - - - - - - - - DctQ k59_947634_2 1121918.ARWE01000001_gene3124 7.41e-72 231.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WKPK@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_896260_1 1121918.ARWE01000001_gene3583 4.51e-104 320.0 COG2414@1|root,COG2414@2|Bacteria,1R5AG@1224|Proteobacteria,42NHF@68525|delta/epsilon subdivisions,2WK3Z@28221|Deltaproteobacteria,43TN7@69541|Desulfuromonadales 28221|Deltaproteobacteria C Aldehyde ferredoxin oxidoreductase, N-terminal domain bamB-1 - 1.2.7.5 ko:K03738,ko:K19515 ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200 M00309,M00541 R08571,R10961 RC00242,RC01839 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_269331_1 435908.IDSA_03625 8.37e-47 163.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,2QFQ8@267893|Idiomarinaceae 1236|Gammaproteobacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901564 - ko:K07082 - - - - ko00000 - - - YceG k59_793735_1 748247.AZKH_2160 5.88e-37 139.0 COG1309@1|root,COG1309@2|Bacteria,1N2QP@1224|Proteobacteria,2WEG2@28216|Betaproteobacteria,2KVNQ@206389|Rhodocyclales 206389|Rhodocyclales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_637021_1 1342299.Z947_4091 1.18e-10 68.2 COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria,3ZWX2@60136|Sulfitobacter 28211|Alphaproteobacteria P Sulfatase MA20_44000 - - - - - - - - - - - DUF4976,Sulfatase k59_322059_1 204669.Acid345_0280 8.38e-55 194.0 COG0574@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0784@2|Bacteria,3Y7G5@57723|Acidobacteria 57723|Acidobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - - - - - - - - - - PPDK_N k59_793737_1 1122939.ATUD01000001_gene66 1.75e-54 189.0 COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4CPV8@84995|Rubrobacteria 84995|Rubrobacteria C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_688906_1 1229780.BN381_90026 4.63e-99 303.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,3UX62@52018|unclassified Actinobacteria (class) 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_62470_1 1007105.PT7_1576 2.73e-82 271.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VHCG@28216|Betaproteobacteria,3T6RJ@506|Alcaligenaceae 28216|Betaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_1105229_1 224911.27350975 1.08e-75 244.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,3JRJV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E GMC oxidoreductase MA20_17575 - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_843855_1 56780.SYN_01990 7.67e-65 214.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2WJ7E@28221|Deltaproteobacteria,2MQ8K@213462|Syntrophobacterales 28221|Deltaproteobacteria L PFAM MgsA AAA ATPase C terminal rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_637042_1 1122599.AUGR01000010_gene1051 1.43e-66 215.0 COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,1RN4G@1236|Gammaproteobacteria,1XHN3@135619|Oceanospirillales 135619|Oceanospirillales C FAD binding domain glcE - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 k59_1471847_1 880073.Calab_2261 3.89e-106 328.0 COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,2NNZ0@2323|unclassified Bacteria 2|Bacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefC - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_1574547_1 1122169.AREN01000008_gene819 1.03e-10 65.9 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1JD0N@118969|Legionellales 118969|Legionellales J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_843874_1 983917.RGE_05390 1.11e-21 100.0 COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VMMZ@28216|Betaproteobacteria,1KMB6@119065|unclassified Burkholderiales 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS,PAS_3,PAS_4,Response_reg,SBP_bac_3,dCache_1 k59_1418340_2 1280380.KR100_02830 4.34e-06 50.4 COG0540@1|root,COG0540@2|Bacteria,1G2UX@1117|Cyanobacteria,1GYHT@1129|Synechococcus 1117|Cyanobacteria F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_322092_1 1123288.SOV_5c02770 6.93e-40 141.0 COG4662@1|root,COG4662@2|Bacteria,1TRK7@1239|Firmicutes,4H2EH@909932|Negativicutes 909932|Negativicutes H Binding-protein-dependent transport system inner membrane component - - - ko:K05773 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - BPD_transp_1 k59_217590_2 1297742.A176_03422 1.76e-25 107.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,42N6U@68525|delta/epsilon subdivisions,2WQ3X@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Lipid A biosynthesis acyltransferase htrB - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_163279_1 160492.XF_0239 4.51e-131 394.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1X3VD@135614|Xanthomonadales 135614|Xanthomonadales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_322690_1 330214.NIDE0228 8.72e-101 312.0 COG1009@1|root,COG1009@2|Bacteria,3J0AN@40117|Nitrospirae 40117|Nitrospirae CP NADH-quinone oxidoreductase - - 1.6.5.3 ko:K00341,ko:K05568,ko:K12139 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_583054_1 472759.Nhal_0506 8.88e-78 243.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,1WWG7@135613|Chromatiales 135613|Chromatiales G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_583054_2 1163407.UU7_05504 4.59e-12 68.2 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1X2ZN@135614|Xanthomonadales 135614|Xanthomonadales S Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - - - - - - - - - - - - Peptidase_M48,TPR_19 k59_1418954_1 550540.Fbal_0469 2.93e-46 154.0 COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria 1236|Gammaproteobacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - iYL1228.KPN_03664 Biotin_lipoyl k59_896874_1 1215092.PA6_007_00050 2.07e-40 152.0 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,1RQ4U@1236|Gammaproteobacteria,1YGPF@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria U Pilus formation protein N terminal region cpaC - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - BON,Secretin,T2SS-T3SS_pil_N k59_163292_1 448385.sce6513 3.68e-85 258.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,42MTW@68525|delta/epsilon subdivisions,2WJ0J@28221|Deltaproteobacteria,2YUI8@29|Myxococcales 28221|Deltaproteobacteria S ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA,AAA_5 k59_63289_1 97138.C820_02226 2.45e-19 92.4 28HYB@1|root,2Z83S@2|Bacteria,1TR86@1239|Firmicutes,24C5E@186801|Clostridia,36MBN@31979|Clostridiaceae 186801|Clostridia S Putative amidoligase enzyme - - - - - - - - - - - - Amidoligase_2 k59_1575183_1 990285.RGCCGE502_12224 1.25e-27 113.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,4BA7W@82115|Rhizobiaceae 28211|Alphaproteobacteria O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_1314252_2 1122201.AUAZ01000005_gene604 9.74e-50 165.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,4649A@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483,ko:K07660 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_1628097_1 706587.Desti_5031 1.42e-60 213.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,Pyr_redox_2 k59_1418972_1 768671.ThimaDRAFT_0605 2.15e-127 379.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WWEY@135613|Chromatiales 135613|Chromatiales C FAD linked oxidase - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_689562_1 686340.Metal_3689 0.000243 43.5 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1XEMT@135618|Methylococcales 135618|Methylococcales H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Glu_cys_ligase k59_689562_2 396588.Tgr7_0212 2.24e-14 72.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1WWQ7@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1366834_1 436308.Nmar_0297 2.15e-07 48.9 arCOG10955@1|root,arCOG10955@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1366834_2 1459636.NTE_00251 5.11e-24 94.0 COG0662@1|root,arCOG03003@2157|Archaea 2157|Archaea G PFAM Cupin 2, conserved barrel domain protein - - - ko:K11312 - - - - ko00000 - - - Cupin_2,Cupin_3 k59_1053515_1 211165.AJLN01000149_gene6676 6.53e-53 180.0 COG1702@1|root,COG1702@2|Bacteria,1G0U5@1117|Cyanobacteria,1JHMM@1189|Stigonemataceae 1117|Cyanobacteria T PhoH-like protein phoH - - ko:K06217 - - - - ko00000 - - - PhoH k59_1628101_1 1082933.MEA186_00170 5.72e-27 115.0 COG2267@1|root,COG3629@1|root,COG2267@2|Bacteria,COG3629@2|Bacteria,1QU9N@1224|Proteobacteria,2TW44@28211|Alphaproteobacteria,43NT3@69277|Phyllobacteriaceae 28211|Alphaproteobacteria IT Ndr family - - - - - - - - - - - - Abhydrolase_1 k59_217619_1 1168067.JAGP01000001_gene94 4.24e-24 107.0 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,1T1GZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_63303_1 159450.NH14_00385 3.88e-37 143.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,1K1DV@119060|Burkholderiaceae 28216|Betaproteobacteria MU TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family - - - ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 - - OEP k59_269971_1 1151127.KB906327_gene1796 1.26e-56 189.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1YN6R@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor bioA GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUTI89_1310.UTI89_C0772,iZ_1308.Z0993 Aminotran_3 k59_478888_1 69328.PVLB_14615 5.4e-85 274.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S720@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Adenylate cyclase - - - - - - - - - - - - TPR_11,TPR_16,TPR_19,TPR_2,TPR_8,Trans_reg_C k59_844511_1 1173264.KI913949_gene2075 4.95e-08 53.1 COG1309@1|root,COG1309@2|Bacteria,1G676@1117|Cyanobacteria 1117|Cyanobacteria K PFAM Bacterial regulatory proteins, tetR family - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N k59_426621_1 644966.Tmar_0595 1.47e-34 135.0 COG0079@1|root,COG0141@1|root,COG0079@2|Bacteria,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,248X8@186801|Clostridia,3WCUR@538999|Clostridiales incertae sedis 186801|Clostridia E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23,1.1.1.308 ko:K00013,ko:K15509 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_1_2,Histidinol_dh k59_426621_2 945713.IALB_0305 8.57e-34 119.0 COG0776@1|root,COG0776@2|Bacteria 2|Bacteria L regulation of translation hup - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_163321_1 330214.NIDE0003 6.97e-94 296.0 COG0187@1|root,COG0187@2|Bacteria,3J0BB@40117|Nitrospirae 40117|Nitrospirae L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_739769_1 1026882.MAMP_00928 2.54e-73 231.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,45ZWY@72273|Thiotrichales 72273|Thiotrichales Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_689578_1 627192.SLG_28180 1.44e-16 84.7 COG2267@1|root,COG2267@2|Bacteria,1RE00@1224|Proteobacteria,2UGX6@28211|Alphaproteobacteria,2K74N@204457|Sphingomonadales 204457|Sphingomonadales I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_426622_1 326427.Cagg_2620 1.59e-43 155.0 COG1215@1|root,COG1215@2|Bacteria,2G9DX@200795|Chloroflexi,377P0@32061|Chloroflexia 32061|Chloroflexia M PFAM glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_637881_1 686340.Metal_2497 3.45e-132 382.0 COG0482@1|root,COG0482@2|Bacteria,1QV6H@1224|Proteobacteria,1RQSV@1236|Gammaproteobacteria,1XH1D@135618|Methylococcales 135618|Methylococcales J Thiamine biosynthesis protein (ThiI) - - - - - - - - - - - - - k59_374453_1 1125863.JAFN01000001_gene1649 2.32e-15 75.9 COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,42SYM@68525|delta/epsilon subdivisions,2WP8C@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_374453_2 269799.Gmet_1262 7.16e-158 452.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria,43TFX@69541|Desulfuromonadales 28221|Deltaproteobacteria F Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_1575212_1 1123073.KB899241_gene2226 5.88e-141 426.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1X333@135614|Xanthomonadales 135614|Xanthomonadales I converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_844522_1 443144.GM21_2798 1.64e-69 233.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria 28221|Deltaproteobacteria C malic protein domain protein maeB - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1637 Malic_M,PTA_PTB,malic k59_844522_2 1254432.SCE1572_42325 1.99e-43 155.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2YU6I@29|Myxococcales 28221|Deltaproteobacteria I Carboxyl transferase domain pccB - 2.1.3.1,2.1.3.15,6.4.1.3 ko:K01966,ko:K17489 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R00353,R01859 RC00040,RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1628123_1 489825.LYNGBM3L_22030 3.79e-79 254.0 COG3961@1|root,COG3961@2|Bacteria,1G1A5@1117|Cyanobacteria,1H9TP@1150|Oscillatoriales 1117|Cyanobacteria GH Belongs to the TPP enzyme family pdc - 4.1.1.74 ko:K04103 ko00380,ko01100,map00380,map01100 - R01974 RC00506 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_169719_1 1123242.JH636435_gene826 1.1e-58 197.0 COG0129@1|root,COG0129@2|Bacteria,2IWXV@203682|Planctomycetes 203682|Planctomycetes H Belongs to the IlvD Edd family ilvD GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_71665_1 706191.PANA_2059 1.52e-40 143.0 COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,3VZJ8@53335|Pantoea 1236|Gammaproteobacteria IQ short-chain dehydrogenase reductase SDR yciK GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575 - - - - - - - - - - adh_short k59_803416_1 314345.SPV1_01822 1.45e-128 369.0 COG2020@1|root,COG2020@2|Bacteria,1R7G6@1224|Proteobacteria 1224|Proteobacteria O Methyl-transferase - - - - - - - - - - - - ICMT,PEMT k59_803416_2 317025.Tcr_1013 8.11e-122 349.0 COG2249@1|root,COG2249@2|Bacteria,1MUHN@1224|Proteobacteria,1RU3S@1236|Gammaproteobacteria,4637K@72273|Thiotrichales 72273|Thiotrichales S Flavodoxin-like fold - - - - - - - - - - - - Flavodoxin_2 k59_1373175_1 795666.MW7_1438 6.21e-46 153.0 COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,2VI3V@28216|Betaproteobacteria,1KFMV@119060|Burkholderiaceae 28216|Betaproteobacteria T Low molecular weight phosphotyrosine protein phosphatase arsC2 - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_432960_1 1410668.JNKC01000002_gene2144 8.8e-18 86.7 COG1840@1|root,COG1840@2|Bacteria,1TQC3@1239|Firmicutes,24B3A@186801|Clostridia,36DI5@31979|Clostridiaceae 186801|Clostridia P PFAM Bacterial extracellular solute-binding protein - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 k59_746137_1 338963.Pcar_0394 6.34e-23 97.4 COG2165@1|root,COG2165@2|Bacteria,1RK34@1224|Proteobacteria,42Y1S@68525|delta/epsilon subdivisions,2WTH8@28221|Deltaproteobacteria,43U7J@69541|Desulfuromonadales 28221|Deltaproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K12285 - - - - ko00000,ko02044 - - - N_methyl k59_119859_1 391595.RLO149_c031200 3.06e-09 65.1 COG2885@1|root,COG2911@1|root,COG2931@1|root,COG2885@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2P3XE@2433|Roseobacter 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - 3.4.24.40 ko:K01406,ko:K07004 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - An_peroxidase,Cadherin,Calx-beta,Exo_endo_phos,HemolysinCabind,Metallophos,Peptidase_M10_C k59_746140_1 1469245.JFBG01000056_gene2467 2.66e-97 305.0 28JZQ@1|root,2Z9PN@2|Bacteria,1N2WN@1224|Proteobacteria,1S4QJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_7042_1 468059.AUHA01000003_gene1742 1.33e-50 171.0 28HGI@1|root,2Z7SC@2|Bacteria,4NJUF@976|Bacteroidetes,1IUS8@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1162877_1 1379701.JPJC01000074_gene2575 9.83e-17 80.5 COG4186@1|root,COG4186@2|Bacteria,1RD94@1224|Proteobacteria,2U7MY@28211|Alphaproteobacteria,2K43W@204457|Sphingomonadales 204457|Sphingomonadales S Phosphoesterase or phosphohydrolase - - - - - - - - - - - - Metallophos_2 k59_537141_1 880073.Calab_2811 8.13e-95 302.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,2NPC4@2323|unclassified Bacteria 2|Bacteria P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - iAF987.Gmet_3470 CBS,TrkA_C,Voltage_CLC k59_904137_1 1229909.NSED_09440 4.85e-114 339.0 COG0004@1|root,arCOG04397@2157|Archaea,41SZ0@651137|Thaumarchaeota 651137|Thaumarchaeota P Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_1061027_1 436308.Nmar_1792 4.4e-135 399.0 COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota 651137|Thaumarchaeota O PFAM TCP-1 cpn60 chaperonin family - - - ko:K22447 - - - - ko00000,ko03110 - - - Cpn60_TCP1 k59_696797_2 326427.Cagg_3109 9.61e-51 173.0 COG2141@1|root,COG2141@2|Bacteria,2G5MF@200795|Chloroflexi,376CU@32061|Chloroflexia 32061|Chloroflexia C PFAM luciferase family protein - - - - - - - - - - - - Bac_luciferase k59_746903_1 1265313.HRUBRA_01287 2.96e-11 64.7 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RMGZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria CH Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively ghrB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008873,GO:0008875,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0019520,GO:0019522,GO:0019752,GO:0030267,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046176,GO:0046181,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.215,1.1.1.43,1.1.1.79,1.1.1.81,1.20.1.1 ko:K00032,ko:K00090,ko:K18916 ko00030,ko00260,ko00480,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00480,map00620,map00630,map01100,map01110,map01120 - R00465,R01388,R01392,R01739,R02032,R02034 RC00001,RC00031,RC00042,RC00084 ko00000,ko00001,ko01000 - - iSFV_1184.SFV_3534 2-Hacid_dh,2-Hacid_dh_C k59_1113045_1 1380394.JADL01000011_gene3988 1.97e-84 271.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQ9H@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_537891_1 1205680.CAKO01000040_gene599 2.27e-50 162.0 COG3785@1|root,COG3785@2|Bacteria,1RHM7@1224|Proteobacteria,2U9MS@28211|Alphaproteobacteria,2JTI6@204441|Rhodospirillales 204441|Rhodospirillales S Hemimethylated DNA-binding protein YccV like - - - ko:K11940 - - - - ko00000,ko03036 - - - YccV-like k59_851695_1 1410622.JNKY01000010_gene1147 0.000559 50.4 COG3857@1|root,COG3857@2|Bacteria,1TQJW@1239|Firmicutes,2487T@186801|Clostridia,27JPS@186928|unclassified Lachnospiraceae 186801|Clostridia L PD-(D/E)XK nuclease superfamily addB - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - Exonuc_V_gamma,PDDEXK_1,UvrD_C k59_120891_1 911045.PSE_2406 3.61e-12 71.6 COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1MUAK@1224|Proteobacteria,2TSUC@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1219962_1 396588.Tgr7_2506 3.8e-80 240.0 28PZA@1|root,2ZCIS@2|Bacteria,1RCMD@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_851697_1 1283299.AUKG01000002_gene4334 4.97e-102 304.0 COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria,4CSIF@84995|Rubrobacteria 84995|Rubrobacteria C Succinyl-CoA ligase like flavodoxin domain - - - - - - - - - - - - CoA_binding,Succ_CoA_lig k59_224859_1 593907.Celgi_0691 2.47e-07 53.1 COG1322@1|root,COG1322@2|Bacteria,2GP4U@201174|Actinobacteria,4F12D@85016|Cellulomonadaceae 201174|Actinobacteria S RmuC family rmuC - - ko:K09760 - - - - ko00000 - - - RmuC k59_224859_2 876269.ARWA01000001_gene266 9.17e-23 105.0 COG2199@1|root,COG4191@1|root,COG3706@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TYH2@28211|Alphaproteobacteria,3NCC3@45404|Beijerinckiaceae 28211|Alphaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_955613_1 1121335.Clst_1721 2.41e-23 110.0 COG0840@1|root,COG0840@2|Bacteria,1UZ0J@1239|Firmicutes,24F2H@186801|Clostridia 186801|Clostridia NT Chemotaxis pilJ - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_170522_2 436308.Nmar_0429 7.86e-28 105.0 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1219970_1 330214.NIDE1707 1.11e-86 279.0 COG0013@1|root,COG0013@2|Bacteria,3J0D3@40117|Nitrospirae 40117|Nitrospirae J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_277431_1 1225184.ALXE01000022_gene2029 1.85e-05 52.4 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily yceJ - - - - - - - - - - - MFS_1,Sugar_tr k59_537897_1 864051.BurJ1DRAFT_1463 1.31e-150 430.0 COG1099@1|root,COG1099@2|Bacteria,1MY2H@1224|Proteobacteria,2VJVP@28216|Betaproteobacteria 28216|Betaproteobacteria S TatD related DNase - - - ko:K07051 - - - - ko00000 - - - TatD_DNase k59_537897_2 864051.BurJ1DRAFT_1460 3.05e-80 251.0 COG0382@1|root,COG0382@2|Bacteria,1RFNQ@1224|Proteobacteria,2W5W3@28216|Betaproteobacteria 28216|Betaproteobacteria H UbiA prenyltransferase family - - - - - - - - - - - - UbiA k59_537900_1 436308.Nmar_0549 3.59e-135 389.0 COG1685@1|root,arCOG01025@2157|Archaea,41SGZ@651137|Thaumarchaeota 651137|Thaumarchaeota E GHMP kinases N terminal domain aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_170528_1 1565129.JSFF01000003_gene2054 1.87e-33 134.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,2QAZD@267890|Shewanellaceae 1236|Gammaproteobacteria M surface antigen variable number repeat protein ytfM GO:0002790,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009279,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045203,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0097347 - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 k59_804441_1 268746.Q58MX1_BPPRM 9.38e-34 135.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_433933_1 582744.Msip34_0683 1.64e-101 310.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,2KM01@206350|Nitrosomonadales 206350|Nitrosomonadales C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_383106_1 1469245.JFBG01000027_gene1470 3.34e-141 417.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria 1224|Proteobacteria E ABC-Type Dipeptide Transport System Periplasmic Component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_851720_1 670487.Ocepr_2061 1.37e-43 162.0 COG3420@1|root,COG3420@2|Bacteria,1WNFU@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P Right handed beta helix region - - - - - - - - - - - - Beta_helix,DUF11 k59_1373962_1 477228.YO5_16925 7.93e-27 114.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,1RMBF@1236|Gammaproteobacteria,1Z1P8@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M COG0859 ADP-heptose LPS heptosyltransferase rfaF GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 iECH74115_1262.ECH74115_4993,iECSP_1301.ECSP_4617,iECs_1301.ECs4498,iG2583_1286.G2583_4359,iZ_1308.Z5047 Glyco_transf_9 k59_1373962_2 378806.STAUR_5559 2.98e-21 88.6 COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,42SGQ@68525|delta/epsilon subdivisions,2WPTP@28221|Deltaproteobacteria,2YZ6S@29|Myxococcales 28221|Deltaproteobacteria IM Cytidylyltransferase-like rfaE - - - - - - - - - - - CTP_transf_like k59_170538_1 1380394.JADL01000001_gene2209 8.44e-64 207.0 COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2TSE9@28211|Alphaproteobacteria,2JST0@204441|Rhodospirillales 204441|Rhodospirillales EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_433940_1 573065.Astex_3013 3.31e-08 55.1 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2U0ZM@28211|Alphaproteobacteria,2KEYW@204458|Caulobacterales 204458|Caulobacterales E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate - - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_433940_2 1121468.AUBR01000044_gene1828 8.15e-19 85.9 COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248W2@186801|Clostridia,42FMH@68295|Thermoanaerobacterales 186801|Clostridia J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_647425_1 444876.E3SQN8_9CAUD 2.09e-40 155.0 4QEE3@10239|Viruses,4QV4S@35237|dsDNA viruses no RNA stage,4QSER@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_72750_1 187944.H8YJB1_9CAUD 2.21e-48 174.0 4QGMJ@10239|Viruses,4QX02@35237|dsDNA viruses no RNA stage,4QSYG@28883|Caudovirales,4QM5B@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_1061085_1 1244869.H261_01462 2.22e-12 72.0 COG0265@1|root,COG0790@1|root,COG0265@2|Bacteria,COG0790@2|Bacteria,1MV63@1224|Proteobacteria,2TS54@28211|Alphaproteobacteria,2JSRF@204441|Rhodospirillales 204441|Rhodospirillales O Trypsin-like peptidase domain - - - - - - - - - - - - Sel1,Trypsin_2 k59_746946_1 2340.JV46_16680 1.73e-31 116.0 COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,1J6IW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G HAD-hyrolase-like gph GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0031404,GO:0033554,GO:0034641,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_3372,iSbBS512_1146.SbBS512_E3762,iYL1228.KPN_03756 HAD_2 k59_746946_2 519989.ECTPHS_03774 1.84e-122 367.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WX6V@135613|Chromatiales 135613|Chromatiales E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1482176_1 1229909.NSED_01125 6.86e-101 312.0 COG1204@1|root,arCOG00553@2157|Archaea,41SAK@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks hel308 - - ko:K03726 - - - - ko00000,ko01000 - - - DEAD,HHH_5,Helicase_C k59_1113103_1 1282876.BAOK01000001_gene2540 9.54e-06 46.6 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,4BPAA@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1113103_2 325777.GW15_0219710 2.3e-10 65.9 COG0845@1|root,COG0845@2|Bacteria,1R73J@1224|Proteobacteria,1S249@1236|Gammaproteobacteria,1X6HC@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K15727 - - - - ko00000,ko02000 8.A.1.2.1 - - HlyD_D23 k59_696855_1 1121439.dsat_0193 5.01e-39 148.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,42NFP@68525|delta/epsilon subdivisions,2WK64@28221|Deltaproteobacteria,2M9T7@213115|Desulfovibrionales 28221|Deltaproteobacteria EQ PFAM Hydantoinase oxoprolinase hyuA - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_590389_1 519989.ECTPHS_07027 2.35e-66 209.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,1WW6U@135613|Chromatiales 135613|Chromatiales G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_1428505_2 1280954.HPO_04135 6.03e-49 163.0 COG2227@1|root,COG2227@2|Bacteria,1R17N@1224|Proteobacteria,2U8MA@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_23,Methyltransf_25 k59_804473_1 290512.Paes_0606 8.8e-81 249.0 COG0189@1|root,COG0189@2|Bacteria,1FEIE@1090|Chlorobi 1090|Chlorobi H Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_120963_1 349124.Hhal_1084 2.39e-93 287.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1X0AC@135613|Chromatiales 135613|Chromatiales C dihydrolipoamide dehydrogenase - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_955663_1 76114.ebA7118 3.87e-22 93.6 COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,2VQ8U@28216|Betaproteobacteria,2KW52@206389|Rhodocyclales 206389|Rhodocyclales F Deoxynucleoside kinase - - - - - - - - - - - - dNK k59_955663_2 1095772.CAHH01000068_gene314 3.07e-24 104.0 COG0801@1|root,COG1539@1|root,COG0801@2|Bacteria,COG1539@2|Bacteria,2H3G6@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folK - 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 - - - FolB,HPPK k59_1428515_1 1316936.K678_11815 2.56e-55 184.0 COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2U0CA@28211|Alphaproteobacteria,2JS5Q@204441|Rhodospirillales 204441|Rhodospirillales G Belongs to the bacterial glucokinase family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase k59_433979_1 1356852.N008_09760 6.17e-39 140.0 COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes,47MGP@768503|Cytophagia 976|Bacteroidetes H Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA kbl - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1274256_1 345341.KUTG_07286 3.54e-35 134.0 COG0477@1|root,COG2814@2|Bacteria,2GMKX@201174|Actinobacteria,4DY8V@85010|Pseudonocardiales 201174|Actinobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1,MFS_3 k59_224917_1 305900.GV64_02350 0.000566 41.2 COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1XM4G@135619|Oceanospirillales 135619|Oceanospirillales K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_224917_2 187272.Mlg_2442 5.81e-74 243.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1589969_2 316273.XCV2263 4.05e-24 94.7 COG2963@1|root,COG2963@2|Bacteria,1N28U@1224|Proteobacteria,1S9BK@1236|Gammaproteobacteria,1XAPX@135614|Xanthomonadales 135614|Xanthomonadales L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_1644950_1 1268303.RHODMAR_1236 1.61e-23 101.0 COG0500@1|root,COG2226@2|Bacteria,2HIVE@201174|Actinobacteria,4G4U7@85025|Nocardiaceae 201174|Actinobacteria Q Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - - - - - - - - - - Methyltransf_31 k59_911562_1 316058.RPB_0141 6.5e-88 270.0 COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,2TWTC@28211|Alphaproteobacteria,3JWWH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1015414_1 1313172.YM304_30670 1.06e-67 226.0 COG0166@1|root,COG0363@1|root,COG0166@2|Bacteria,COG0363@2|Bacteria,2GJG0@201174|Actinobacteria,4CMVT@84992|Acidimicrobiia 84992|Acidimicrobiia G Phosphoglucose isomerase pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_859142_2 429009.Adeg_0940 3.9e-30 115.0 COG1618@1|root,COG1618@2|Bacteria,1VE8K@1239|Firmicutes,24Q8Z@186801|Clostridia,42IED@68295|Thermoanaerobacterales 186801|Clostridia F NTPase - - 3.6.1.15 ko:K06928 ko00230,ko00730,ko01100,map00230,map00730,map01100 - R00086,R00615 RC00002 ko00000,ko00001,ko01000 - - - NTPase_1 k59_498329_1 649638.Trad_1076 1.01e-14 79.0 COG0037@1|root,COG0590@1|root,COG0037@2|Bacteria,COG0590@2|Bacteria,1WIEH@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus DFJ Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tadA - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,MafB19-deam,TilS_C,dCMP_cyt_deam_1 k59_657160_2 614083.AWQR01000046_gene3347 1.07e-07 56.2 COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2VM3A@28216|Betaproteobacteria,4AFGH@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Sel1 domain protein repeat-containing protein - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_962621_1 330214.NIDE2738 1.73e-80 243.0 COG0634@1|root,COG0634@2|Bacteria,3J0NZ@40117|Nitrospirae 40117|Nitrospirae F Phosphoribosyl transferase domain hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_1589982_1 290397.Adeh_1284 3.62e-16 81.3 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIVD@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU General secretory system II, protein E domain protein pulE-3 - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1228656_1 933262.AXAM01000004_gene2391 1.57e-33 125.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42Q40@68525|delta/epsilon subdivisions,2WKYI@28221|Deltaproteobacteria,2MJHB@213118|Desulfobacterales 28221|Deltaproteobacteria T helix_turn_helix, Lux Regulon - - - ko:K02479 - - - - ko00000,ko02022 - - - GerE,Response_reg k59_284799_1 234267.Acid_5798 9.34e-60 208.0 COG0841@1|root,COG0841@2|Bacteria,3Y79D@57723|Acidobacteria 57723|Acidobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_814214_1 861299.J421_3812 1.41e-130 393.0 COG0296@1|root,COG0296@2|Bacteria,1ZT8Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_231863_1 1006006.Mcup_0005 9.84e-20 88.6 COG1912@1|root,arCOG04309@2157|Archaea,2XQIS@28889|Crenarchaeota 28889|Crenarchaeota S PFAM S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans k59_657171_1 526224.Bmur_2446 1.02e-18 87.4 COG0206@1|root,COG0206@2|Bacteria,2J5EQ@203691|Spirochaetes 203691|Spirochaetes D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_231864_1 1379281.AVAG01000011_gene1297 6.53e-109 339.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42MZJ@68525|delta/epsilon subdivisions,2WJK1@28221|Deltaproteobacteria,2M804@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Aldehyde ferredoxin oxidoreductase aorA - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_1325428_1 1408303.JNJJ01000054_gene1391 3.81e-07 51.2 COG0240@1|root,COG0240@2|Bacteria,1TQ5P@1239|Firmicutes,4HAXW@91061|Bacilli,1ZCHQ@1386|Bacillus 91061|Bacilli I Glycerol-3-phosphate dehydrogenase gpsA GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0047952,GO:0055114 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_1325428_2 1026882.MAMP_00946 1.07e-38 134.0 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,460QW@72273|Thiotrichales 72273|Thiotrichales U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB - - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_1380757_2 644282.Deba_0133 1.7e-18 85.1 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,42MSF@68525|delta/epsilon subdivisions,2WKJ5@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - iAF987.Gmet_1099 AlaDh_PNT_C,AlaDh_PNT_N k59_442366_1 929558.SMGD1_1968 8.01e-08 58.9 COG0451@1|root,COG0451@2|Bacteria,1Q1MW@1224|Proteobacteria,42QQU@68525|delta/epsilon subdivisions,2YP2V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria GM GDP-mannose 4,6 dehydratase - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_442366_2 1123326.JFBL01000001_gene1534 1.41e-51 176.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42M4C@68525|delta/epsilon subdivisions,2YMFK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the DegT DnrJ EryC1 family wlaK - 2.6.1.98 ko:K13017 ko00520,map00520 - R10141 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k59_911584_1 391615.ABSJ01000059_gene2177 8.66e-65 199.0 COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,1S6Y1@1236|Gammaproteobacteria,1J6ER@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional VL23_01195 - - - - - - - - - - - MerR_1 k59_1438038_1 1123073.KB899243_gene625 4.9e-55 183.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1X36D@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_1438038_2 314287.GB2207_00300 7.52e-07 51.6 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1J56M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_129621_1 592010.GCWU000182_001103 9.42e-63 213.0 COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,4H9VD@91061|Bacilli,27DH4@186827|Aerococcaceae 91061|Bacilli G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0051179,GO:0051234,GO:0071702 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_1068335_1 485916.Dtox_0214 1.51e-61 214.0 COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,2600Y@186807|Peptococcaceae 186801|Clostridia L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_390990_1 344747.PM8797T_18941 2.79e-145 432.0 COG2192@1|root,COG2192@2|Bacteria,2IYCS@203682|Planctomycetes 203682|Planctomycetes O Carbamoyltransferase C-terminus - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_390990_2 91464.S7335_4510 0.000164 51.2 COG0500@1|root,COG2226@2|Bacteria,1G1DE@1117|Cyanobacteria,1GYY7@1129|Synechococcus 1117|Cyanobacteria H Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0051741 2.1.1.295 ko:K18534 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00112 R07501,R10709,R10710 RC00003,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_390990_3 41431.PCC8801_3454 3.93e-12 60.8 2EGPU@1|root,33AFZ@2|Bacteria,1G9QJ@1117|Cyanobacteria,3KISQ@43988|Cyanothece 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_1530928_1 56780.SYN_02166 1.1e-47 161.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,42QQ4@68525|delta/epsilon subdivisions,2WQGH@28221|Deltaproteobacteria,2MQNN@213462|Syntrophobacterales 28221|Deltaproteobacteria I CDP-alcohol phosphatidyltransferase pgsA - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_1590028_1 1207063.P24_10031 7.32e-101 304.0 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2TR7D@28211|Alphaproteobacteria,2JRC6@204441|Rhodospirillales 204441|Rhodospirillales C CoA-transferase family III - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_597688_2 869210.Marky_0739 6e-96 290.0 COG0451@1|root,COG0451@2|Bacteria,1WMCY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M PFAM NAD dependent epimerase dehydratase family - - - - - - - - - - - - Epimerase k59_231899_1 330214.NIDE1225 1.45e-33 121.0 COG0299@1|root,COG0299@2|Bacteria,3J0MC@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_1015472_1 998674.ATTE01000001_gene215 4.68e-30 120.0 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria,4600Z@72273|Thiotrichales 72273|Thiotrichales J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides rnd - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_1068352_1 1229909.NSED_00210 6.53e-89 273.0 COG0252@1|root,arCOG01924@2157|Archaea,41SD7@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate gatD - 6.3.5.7 ko:K09482 ko00970,ko01100,map00970,map01100 - R03905 RC00010 ko00000,ko00001,ko01000 - - - Asparaginase k59_704107_2 1096546.WYO_0597 5.34e-07 51.2 COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,2U77Q@28211|Alphaproteobacteria,1JUJX@119045|Methylobacteriaceae 28211|Alphaproteobacteria FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.1,3.5.4.3,3.5.4.33 ko:K01485,ko:K01487,ko:K11991 ko00230,ko00240,ko00330,ko01100,map00230,map00240,map00330,map01100 - R00974,R01411,R01676,R02922,R10223 RC00074,RC00204,RC00477,RC00514,RC00809 ko00000,ko00001,ko01000,ko03016 - - - MafB19-deam,dCMP_cyt_deam_1 k59_1380786_1 436308.Nmar_1452 1.03e-34 123.0 arCOG05529@1|root,arCOG05529@2157|Archaea,41SSJ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - dsDNA_bind k59_1380786_2 1229909.NSED_07975 1.51e-40 136.0 arCOG08729@1|root,arCOG08729@2157|Archaea,41T8R@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1380786_3 1229909.NSED_07970 5.03e-55 174.0 COG0100@1|root,arCOG04240@2157|Archaea,41SII@651137|Thaumarchaeota 651137|Thaumarchaeota J Located on the platform of the 30S subunit rps11 - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_337179_1 56107.Cylst_3064 4.61e-55 178.0 COG1515@1|root,COG1515@2|Bacteria,1G2HF@1117|Cyanobacteria,1HKHQ@1161|Nostocales 1117|Cyanobacteria L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA nfi - 3.1.21.7 ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 k59_337179_2 1121940.AUDZ01000006_gene276 2.46e-22 91.3 COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria 1224|Proteobacteria O Peroxiredoxin VY92_02980 - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - Glutaredoxin,Redoxin k59_597696_1 123899.JPQP01000019_gene2649 4.92e-33 129.0 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2VHCE@28216|Betaproteobacteria,3T1E6@506|Alcaligenaceae 28216|Betaproteobacteria F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_129647_1 926560.KE387025_gene3982 2.31e-79 247.0 COG1136@1|root,COG1136@2|Bacteria,1WM2T@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus V COGs COG1136 ABC-type antimicrobial peptide transport system ATPase component - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_657239_1 330214.NIDE4087 1.9e-71 224.0 COG0552@1|root,COG0552@2|Bacteria,3J0GY@40117|Nitrospirae 40117|Nitrospirae D Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_754250_1 357808.RoseRS_2844 9.26e-37 142.0 COG2204@1|root,COG3829@1|root,COG4191@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,2G7PG@200795|Chloroflexi,3763G@32061|Chloroflexia 32061|Chloroflexia T SMART PAS domain containing protein - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_4,Response_reg k59_1491863_1 225849.swp_2750 2.9e-28 112.0 COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,2Q8PT@267890|Shewanellaceae 1236|Gammaproteobacteria L Belongs to the DnaA family hda GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113 - ko:K10763 - - - - ko00000,ko03032 - - - Bac_DnaA k59_1284243_1 686340.Metal_3282 2.37e-68 214.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,1RRVZ@1236|Gammaproteobacteria,1XEBI@135618|Methylococcales 135618|Methylococcales S Belongs to the BI1 family - - - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_1068368_1 546271.Selsp_1823 9.11e-29 119.0 COG0769@1|root,COG0770@1|root,COG0769@2|Bacteria,COG0770@2|Bacteria,1TPQE@1239|Firmicutes,4H2VD@909932|Negativicutes 909932|Negativicutes M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.10,6.3.2.13 ko:K01928,ko:K15792 ko00300,ko00550,map00300,map00550 - R02788,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1228737_1 65393.PCC7424_4879 3.3e-101 313.0 COG3961@1|root,COG3961@2|Bacteria,1G1A5@1117|Cyanobacteria,3KFXX@43988|Cyanothece 1117|Cyanobacteria C Thiamine pyrophosphate enzyme, central domain pdc - 4.1.1.74 ko:K04103 ko00380,ko01100,map00380,map01100 - R01974 RC00506 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1380798_1 266117.Rxyl_3050 2.03e-38 141.0 COG1071@1|root,COG1071@2|Bacteria,2I3T8@201174|Actinobacteria,4CU2B@84995|Rubrobacteria 84995|Rubrobacteria C Transketolase, thiamine diphosphate binding domain - - 1.2.4.1 ko:K00161,ko:K21416 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_337194_1 267608.RSc3319 1.32e-105 319.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,1K1JD@119060|Burkholderiaceae 28216|Betaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1438092_1 522306.CAP2UW1_1975 1.84e-10 58.5 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cusB - - ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_442437_1 570952.ATVH01000015_gene1317 4.28e-109 325.0 COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TU4H@28211|Alphaproteobacteria,2JRHB@204441|Rhodospirillales 204441|Rhodospirillales G Belongs to the HpcH HpaI aldolase family - - 4.1.3.24,4.1.3.25 ko:K08691 ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,map00630,map00660,map00680,map00720,map01120,map01200 M00346,M00373,M00376 R00237,R00473,R00934 RC00307,RC00308,RC00311,RC00407,RC00502,RC01205 ko00000,ko00001,ko00002,ko01000 - - - HpcH_HpaI k59_1438094_1 436308.Nmar_1764 1.18e-47 160.0 arCOG08028@1|root,arCOG08028@2157|Archaea,41SWE@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1438094_2 436308.Nmar_1763 8.61e-65 208.0 COG0520@1|root,arCOG00065@2157|Archaea,41SYH@651137|Thaumarchaeota 651137|Thaumarchaeota E Aminotransferase class-V - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_597719_1 745310.G432_09560 1.15e-138 405.0 2BWJ3@1|root,2Z8E8@2|Bacteria,1QZVQ@1224|Proteobacteria,2TYF6@28211|Alphaproteobacteria,2KEMF@204457|Sphingomonadales 204457|Sphingomonadales S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_1228751_1 114615.BRADO0007 7.49e-42 151.0 COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TU63@28211|Alphaproteobacteria,3JVEM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_657276_1 1458462.JNLK01000001_gene2625 3.68e-11 69.3 COG4412@1|root,COG5263@1|root,COG4412@2|Bacteria,COG5263@2|Bacteria,1UYZF@1239|Firmicutes,24JRR@186801|Clostridia 186801|Clostridia G Pkd domain containing protein - - - - - - - - - - - - F5_F8_type_C,Peptidase_M6 k59_1438108_1 67281.JNZZ01000008_gene5750 5.01e-05 48.9 COG2761@1|root,COG2761@2|Bacteria 2|Bacteria Q protein disulfide oxidoreductase activity - - - - - - - - - - - - DSBA k59_1438108_2 247490.KSU1_C0854 6.9e-06 48.5 COG0430@1|root,COG0430@2|Bacteria,2IYUF@203682|Planctomycetes 203682|Planctomycetes A Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP rtcA - 6.5.1.4 ko:K01974 - - - - ko00000,ko01000 - - - RTC,RTC_insert k59_1590069_1 1238182.C882_2156 4.87e-16 78.6 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,2TSIP@28211|Alphaproteobacteria,2JPR1@204441|Rhodospirillales 204441|Rhodospirillales M 3-beta hydroxysteroid dehydrogenase/isomerase family - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_1590069_2 370438.PTH_1095 1.68e-75 236.0 COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,25EDZ@186801|Clostridia,261N7@186807|Peptococcaceae 186801|Clostridia M Polysaccharide biosynthesis protein - - 5.1.3.2,5.1.3.20,5.1.3.7 ko:K01784,ko:K02473,ko:K03274 ko00052,ko00520,ko00540,ko01100,map00052,map00520,map00540,map01100 M00064,M00361,M00362,M00632 R00291,R00418,R02984,R05176 RC00289,RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase,GDP_Man_Dehyd k59_754285_1 1211115.ALIQ01000197_gene38 4.46e-21 95.9 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_442467_1 76869.PputGB1_1714 0.000553 44.3 2DP7B@1|root,330UW@2|Bacteria,1QVJ5@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF4406) - - - - - - - - - - - - DUF4406 k59_442467_2 1542498.A0A088FSB1_9CAUD 0.000865 45.8 4QFN3@10239|Viruses,4QQ4M@28883|Caudovirales,4QNXC@10744|Podoviridae 10744|Podoviridae S exonuclease activity - - - - - - - - - - - - - k59_443607_1 765911.Thivi_4575 2.6e-85 274.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1WWT9@135613|Chromatiales 135613|Chromatiales O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1016456_1 1340493.JNIF01000003_gene3199 1.83e-12 72.8 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_1229957_2 205869.Q857Q0_9CAUD 1.75e-36 129.0 4QDM7@10239|Viruses,4R03F@35237|dsDNA viruses no RNA stage,4QPZC@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_705042_1 318167.Sfri_0290 1.55e-120 365.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,2QAFC@267890|Shewanellaceae 1236|Gammaproteobacteria P TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - CitMHS,TrkA_C k59_755217_1 222534.KB893719_gene1012 2.7e-42 148.0 COG2141@1|root,COG2141@2|Bacteria,2GMRE@201174|Actinobacteria,4EU7W@85013|Frankiales 201174|Actinobacteria C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Bac_luciferase k59_755217_2 1206744.BAGL01000064_gene4541 4.07e-27 109.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4FTXB@85025|Nocardiaceae 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_499694_2 59374.Fisuc_0498 1.07e-12 74.3 2DBVG@1|root,2ZBB1@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_963695_2 502025.Hoch_5396 7.45e-145 416.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42N64@68525|delta/epsilon subdivisions,2WJ73@28221|Deltaproteobacteria,2Z00Y@29|Myxococcales 28221|Deltaproteobacteria U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_130888_1 880070.Cycma_1309 1.5e-28 112.0 COG0414@1|root,COG0414@2|Bacteria,4NFT9@976|Bacteroidetes,47MNB@768503|Cytophagia 976|Bacteroidetes H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_511082_1 760568.Desku_1151 2.94e-60 205.0 COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,260TC@186807|Peptococcaceae 186801|Clostridia M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_511082_2 397945.Aave_0818 2.01e-12 68.9 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2VHAP@28216|Betaproteobacteria,4ABVH@80864|Comamonadaceae 28216|Betaproteobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_348064_1 314275.MADE_000001021755 4.64e-50 179.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,46415@72275|Alteromonadaceae 1236|Gammaproteobacteria OU COG0616 Periplasmic serine proteases (ClpP class) sppA GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_1296849_1 526227.Mesil_1713 2.26e-35 129.0 COG0039@1|root,COG0039@2|Bacteria,1WJHY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Catalyzes the reversible oxidation of malate to oxaloacetate mdh GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_1296849_2 1205680.CAKO01000025_gene4630 5.99e-23 94.0 2B14M@1|root,31TIF@2|Bacteria,1RH0J@1224|Proteobacteria,2UDJQ@28211|Alphaproteobacteria,2JX12@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function (DUF2938) - - - - - - - - - - - - DUF2938 k59_1447732_1 697282.Mettu_3990 2.91e-161 485.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1RNIF@1236|Gammaproteobacteria,1XE0G@135618|Methylococcales 135618|Methylococcales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1538915_1 1288826.MSNKSG1_13507 3.91e-18 82.8 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,465UN@72275|Alteromonadaceae 1236|Gammaproteobacteria F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_1538915_2 1123368.AUIS01000011_gene1154 7.01e-65 202.0 COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,1S6WA@1236|Gammaproteobacteria,2NCX5@225057|Acidithiobacillales 225057|Acidithiobacillales F Phosphoribosyl transferase domain - - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran k59_1538915_3 641149.HMPREF9016_00434 2.64e-24 98.2 COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2VUH0@28216|Betaproteobacteria,2KR8J@206351|Neisseriales 206351|Neisseriales L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yqgF - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_1538915_4 765910.MARPU_15875 3.58e-46 154.0 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1WX8T@135613|Chromatiales 135613|Chromatiales K Belongs to the UPF0301 (AlgH) family - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_1296864_1 448385.sce2034 7.78e-47 166.0 COG1641@1|root,COG1641@2|Bacteria,1MUKU@1224|Proteobacteria,42MHQ@68525|delta/epsilon subdivisions,2WJAC@28221|Deltaproteobacteria,2YUS7@29|Myxococcales 28221|Deltaproteobacteria S Belongs to the LarC family - - 4.99.1.12 ko:K09121 - - - - ko00000,ko01000 - - - DUF111 k59_511108_1 509635.N824_16465 2.62e-07 55.8 COG0810@1|root,COG0810@2|Bacteria 2|Bacteria M energy transducer activity - - - - - - - - - - - - Peptidase_M56,Plug,TonB_C k59_1504530_1 264201.pc0672 8.94e-81 257.0 COG0415@1|root,COG0415@2|Bacteria,2JFX9@204428|Chlamydiae 204428|Chlamydiae L DNA photolyase phrB - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_453926_1 401053.AciPR4_2800 3.97e-184 544.0 COG1048@1|root,COG1048@2|Bacteria,3Y34Q@57723|Acidobacteria,2JHMV@204432|Acidobacteriia 204432|Acidobacteriia C aconitate hydratase - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1024253_1 572480.Arnit_0033 3.1e-06 53.5 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2YMTF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239,ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1131652_1 1260251.SPISAL_04085 7.81e-24 91.3 COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,1SC9G@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL32 family rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p k59_1131652_2 717774.Marme_2005 1.01e-24 101.0 COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,1RRK3@1236|Gammaproteobacteria,1XJKJ@135619|Oceanospirillales 135619|Oceanospirillales S metal-binding, possibly nucleic acid-binding protein - - - ko:K07040 - - - - ko00000 - - - DUF177 k59_606174_1 396588.Tgr7_2029 2.43e-38 138.0 COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,1S0GF@1236|Gammaproteobacteria,1X0AW@135613|Chromatiales 135613|Chromatiales S Serine aminopeptidase, S33 - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 k59_399143_1 459495.SPLC1_S220160 1.65e-13 76.3 COG0778@1|root,COG0778@2|Bacteria,1G0G3@1117|Cyanobacteria,1H7D8@1150|Oscillatoriales 1117|Cyanobacteria C TIGRFAM SagB-type dehydrogenase domain - - - - - - - - - - - - Nitroreductase k59_971832_1 994479.GL877878_gene2715 5.82e-35 129.0 COG1159@1|root,COG1159@2|Bacteria,2GJJE@201174|Actinobacteria,4DXE1@85010|Pseudonocardiales 201174|Actinobacteria S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_971832_2 883126.HMPREF9710_00921 3.19e-07 52.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,475D0@75682|Oxalobacteraceae 28216|Betaproteobacteria I Thiolase, C-terminal domain thlA_2 - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_762842_1 330214.NIDE1418 4.87e-82 251.0 COG1386@1|root,COG1386@2|Bacteria,3J15Z@40117|Nitrospirae 40117|Nitrospirae D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_606179_1 744979.R2A130_1725 2.08e-52 186.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily gsiA3 - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_1296899_1 1278073.MYSTI_05376 4.18e-85 270.0 COG2211@1|root,COG2211@2|Bacteria,1QTSE@1224|Proteobacteria,43C8U@68525|delta/epsilon subdivisions,2X7J6@28221|Deltaproteobacteria,2Z3H1@29|Myxococcales 28221|Deltaproteobacteria G Acetyl-coenzyme A transporter 1 - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_511144_1 1121859.KB890750_gene264 1.48e-38 145.0 COG3119@1|root,COG3119@2|Bacteria,4NGX1@976|Bacteroidetes,47K2H@768503|Cytophagia 976|Bacteroidetes P Sulfatase - - - - - - - - - - - - Sulfatase k59_554165_2 391595.RLO149_c041100 2.45e-05 45.1 COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,2U7H5@28211|Alphaproteobacteria,2P4M3@2433|Roseobacter 28211|Alphaproteobacteria M Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - - - - - - - - - - Fasciclin k59_1079602_1 479434.Sthe_2697 4.75e-57 185.0 COG1656@1|root,COG1977@1|root,COG1656@2|Bacteria,COG1977@2|Bacteria,2G6GZ@200795|Chloroflexi,27Y8I@189775|Thermomicrobia 189775|Thermomicrobia H Mut7-C ubiquitin - - - ko:K09122 - - - - ko00000 - - - Mut7-C,Ub-Mut7C k59_1538962_1 686578.AFFX01000001_gene1581 2.82e-42 148.0 COG5429@1|root,COG5429@2|Bacteria,1MW6R@1224|Proteobacteria,1S834@1236|Gammaproteobacteria 1236|Gammaproteobacteria S secreted protein - - - - - - - - - - - - DUF1223 k59_1504593_1 1380393.JHVP01000003_gene1268 2.9e-90 280.0 COG1073@1|root,COG2114@1|root,COG1073@2|Bacteria,COG2114@2|Bacteria,2IASU@201174|Actinobacteria 201174|Actinobacteria IT Pfam Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - Abhydrolase_1,Guanylate_cyc k59_184135_1 1121939.L861_07830 3.17e-74 234.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1XI0C@135619|Oceanospirillales 135619|Oceanospirillales H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_1657857_1 765910.MARPU_04140 2.51e-171 493.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1WWTW@135613|Chromatiales 135613|Chromatiales S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_1333772_2 196162.Noca_4298 0.000222 43.9 COG1960@1|root,COG1960@2|Bacteria,2I8DF@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - ko:K04117 ko00362,ko01120,map00362,map01120 M00540 R05619 RC02035 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1333772_3 402881.Plav_1102 9.36e-16 76.3 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria,1JNS3@119043|Rhodobiaceae 28211|Alphaproteobacteria S PFAM Alcohol dehydrogenase zinc-binding domain protein MA20_40260 - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N k59_1177570_3 1232446.BAIE02000065_gene3713 4.82e-18 88.6 COG3598@1|root,COG3598@2|Bacteria,1TU5N@1239|Firmicutes,247KK@186801|Clostridia 186801|Clostridia L COG NOG19743 non supervised orthologous group - - - - - - - - - - - - AAA_25 k59_1333775_1 472759.Nhal_0357 2.73e-69 221.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales 1236|Gammaproteobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_762889_1 1210884.HG799466_gene12833 2.43e-25 103.0 COG2957@1|root,COG2957@2|Bacteria,2IXRY@203682|Planctomycetes 203682|Planctomycetes E Belongs to the agmatine deiminase family aguA - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph k59_1390100_2 1232410.KI421421_gene3632 6.7e-50 170.0 COG0656@1|root,COG0656@2|Bacteria 2|Bacteria S aldo-keto reductase (NADP) activity - - 1.1.1.65 ko:K05275 ko00750,ko01100,ko01120,map00750,map01100,map01120 - R01708 RC00116 ko00000,ko00001,ko01000 - - - Aldo_ket_red k59_763920_1 330214.NIDE2073 1.78e-87 276.0 COG1389@1|root,COG1389@2|Bacteria 2|Bacteria L DNA topoisomerase II activity top6B - 5.99.1.3 ko:K03167 - - - - ko00000,ko01000,ko03032 - - - HATPase_c,HATPase_c_3,Topo-VIb_trans k59_828646_1 397948.Cmaq_0373 1.48e-60 201.0 COG0281@1|root,arCOG00853@2157|Archaea,2XPUQ@28889|Crenarchaeota 28889|Crenarchaeota C malic enzyme - - 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic k59_1448674_1 400668.Mmwyl1_1533 7.88e-82 254.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,1XHA8@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_714417_1 880073.Calab_1598 1.07e-64 221.0 COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria 2|Bacteria P Prokaryotic cytochrome b561 cbcY - - - - - - - - - - - Cytochrom_c3_2,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese k59_924294_1 667014.Thein_1400 3.28e-09 58.5 COG1934@1|root,COG1934@2|Bacteria,2GHYI@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S OstA-like protein - - - ko:K09774 - - - - ko00000,ko02000 1.B.42.1 - - OstA k59_924294_2 517418.Ctha_1039 4.88e-38 135.0 COG1137@1|root,COG1137@2|Bacteria,1FDNI@1090|Chlorobi 1090|Chlorobi S PFAM ABC transporter related - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_185078_2 1219084.AP014508_gene1174 1.48e-30 115.0 COG0218@1|root,COG0218@2|Bacteria,2GCYP@200918|Thermotogae 200918|Thermotogae D Necessary for normal cell division and for the maintenance of normal septation engB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_95889_1 1123368.AUIS01000010_gene2375 1.59e-81 258.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1S14K@1236|Gammaproteobacteria,2NBXM@225057|Acidithiobacillales 225057|Acidithiobacillales J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) - - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_828675_1 1121875.KB907555_gene370 5.18e-111 329.0 COG1830@1|root,COG1830@2|Bacteria,4NEUM@976|Bacteroidetes,1HZ0Q@117743|Flavobacteriia 976|Bacteroidetes G PFAM DeoC LacD family aldolase fbaB - 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - DeoC k59_828675_2 498761.HM1_1603 1.69e-81 258.0 COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia 186801|Clostridia F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_1539913_1 1335757.SPICUR_00495 8.92e-49 169.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria,1WWJG@135613|Chromatiales 135613|Chromatiales S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_671533_1 583345.Mmol_0653 2.21e-66 224.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,2KKET@206350|Nitrosomonadales 206350|Nitrosomonadales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_671533_2 322710.Avin_44900 1.49e-55 193.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0339 Transketolase_N k59_1390134_1 317025.Tcr_0758 6.96e-26 104.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1RN67@1236|Gammaproteobacteria,461S9@72273|Thiotrichales 72273|Thiotrichales NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_1390134_2 1116472.MGMO_25c00370 8.49e-39 135.0 COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,1S41X@1236|Gammaproteobacteria,1XEGP@135618|Methylococcales 135618|Methylococcales NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis - - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD k59_607147_2 1288484.APCS01000151_gene1383 1.79e-52 184.0 COG1132@1|root,COG1132@2|Bacteria,1WJ5B@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus V ABC-type multidrug transport system ATPase and permease - - - ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_1334702_1 1449065.JMLL01000010_gene215 2.15e-17 88.6 COG0642@1|root,COG0642@2|Bacteria,1QTVA@1224|Proteobacteria,2U5EI@28211|Alphaproteobacteria,43RTQ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain MA20_15235 - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1298514_1 330214.NIDE1643 6.78e-109 332.0 COG0365@1|root,COG0365@2|Bacteria,3J0BJ@40117|Nitrospirae 40117|Nitrospirae I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_763969_1 323261.Noc_2665 5.82e-85 272.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1WW5E@135613|Chromatiales 135613|Chromatiales J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_400169_1 395493.BegalDRAFT_0127 2.48e-51 180.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,4608P@72273|Thiotrichales 72273|Thiotrichales G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_973006_1 1192034.CAP_7544 2.96e-52 185.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,2YUKG@29|Myxococcales 28221|Deltaproteobacteria F Carbamoyl-phosphate synthetase ammonia chain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,GATase,MGS k59_1241287_1 1122604.JONR01000025_gene4582 2.73e-26 102.0 COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,1X6EJ@135614|Xanthomonadales 135614|Xanthomonadales K Ribosomal-protein-alanine acetyltransferase rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_1241287_2 637390.AFOH01000056_gene1571 4.61e-44 153.0 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,1S2U7@1236|Gammaproteobacteria,2NC0V@225057|Acidithiobacillales 225057|Acidithiobacillales L Uracil DNA glycosylase superfamily - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_185125_1 1049564.TevJSym_bb00290 1.33e-65 223.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T216@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg k59_1178531_1 1323663.AROI01000007_gene2681 4.16e-73 231.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1448729_1 215358.XP_010737360.1 6.51e-18 80.1 COG1324@1|root,KOG3338@2759|Eukaryota,3A1S2@33154|Opisthokonta,3BQH3@33208|Metazoa,3D77M@33213|Bilateria,481RA@7711|Chordata,49BFJ@7742|Vertebrata,4A3AM@7898|Actinopterygii 33208|Metazoa P cutA divalent cation tolerance homolog (E. coli) CUTA GO:0003674,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0008104,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0019899,GO:0022607,GO:0033036,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0046872,GO:0046914,GO:0051179,GO:0051259,GO:0051260,GO:0065003,GO:0071840 - ko:K03926 - - - - ko00000 - - - CutA1 k59_973010_1 1123371.ATXH01000021_gene1134 1.83e-22 97.8 COG0711@1|root,COG0711@2|Bacteria,2GHRB@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_185129_1 391937.NA2_00895 2.45e-54 181.0 COG0391@1|root,COG0391@2|Bacteria,1NK78@1224|Proteobacteria,2TUUA@28211|Alphaproteobacteria,43JUE@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S 2-phospho-L-lactate transferase cofD - 2.7.8.28 ko:K11212 ko00680,ko01120,map00680,map01120 M00378 R09398 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - UPF0052 k59_422000_3 765914.ThisiDRAFT_0694 2e-89 287.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1WXCW@135613|Chromatiales 135613|Chromatiales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_1258637_1 76114.ebA1185 9.13e-78 247.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,2KUH8@206389|Rhodocyclales 206389|Rhodocyclales O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groEL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1258637_2 765914.ThisiDRAFT_0398 2.83e-47 153.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,1WYJ2@135613|Chromatiales 135613|Chromatiales O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_578642_2 443144.GM21_3603 3.03e-24 102.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NV6@68525|delta/epsilon subdivisions,2WIPB@28221|Deltaproteobacteria,43TPR@69541|Desulfuromonadales 28221|Deltaproteobacteria E Aminotransferase class I and II cobD - 4.1.1.81 ko:K04720 ko00860,map00860 - R06530 RC00517 ko00000,ko00001,ko01000 - - iAF987.Gmet_0487 Aminotran_1_2 k59_1623412_1 1177179.A11A3_13590 9.19e-92 280.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1XIP7@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_996143_1 1236959.BAMT01000001_gene1012 1.85e-177 511.0 COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,2VHAK@28216|Betaproteobacteria,2KKWD@206350|Nitrosomonadales 206350|Nitrosomonadales O Carbamoyltransferase C-terminus - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_422007_1 189753.AXAS01000031_gene4399 2.09e-05 52.0 COG3917@1|root,COG3917@2|Bacteria,1RA6I@1224|Proteobacteria,2U5JB@28211|Alphaproteobacteria,3JRJN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q DSBA-like thioredoxin domain MA20_25040 - 5.99.1.4 ko:K14584 ko00626,ko01100,ko01120,ko01220,map00626,map01100,map01120,map01220 M00534 R05137 RC03084 br01602,ko00000,ko00001,ko00002,ko01000 - - - DSBA k59_1101179_1 314270.RB2083_909 1.02e-67 212.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,3ZIFX@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria L L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve,rve_3 k59_213019_2 1380391.JIAS01000014_gene2059 4.43e-09 57.0 COG1250@1|root,COG1250@2|Bacteria,1MV8M@1224|Proteobacteria,2TRAW@28211|Alphaproteobacteria,2JQXY@204441|Rhodospirillales 204441|Rhodospirillales I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - 3HCDH,3HCDH_N k59_2314_1 931627.MycrhDRAFT_5354 8.09e-28 115.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,23CSB@1762|Mycobacteriaceae 201174|Actinobacteria C Cytochrome P450 - - 1.14.13.221 ko:K16046 ko00984,ko01120,map00984,map01120 - R09859,R11361 RC01216,RC03368 ko00000,ko00001,ko00199,ko01000 - - - p450 k59_1466933_1 1449353.JQMQ01000004_gene6136 1.39e-19 94.0 COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria,2NFQA@228398|Streptacidiphilus 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1258658_1 637389.Acaty_c1958 2.18e-16 84.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,2NCRI@225057|Acidithiobacillales 225057|Acidithiobacillales CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_527066_1 207954.MED92_04649 3.11e-66 218.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1XHQ8@135619|Oceanospirillales 135619|Oceanospirillales CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases ubiH - - ko:K03185 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04989,R08773 RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_474847_1 1123401.JHYQ01000002_gene2646 3.99e-110 334.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,4600M@72273|Thiotrichales 72273|Thiotrichales O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1467833_1 1458427.BAWN01000017_gene1127 2.07e-45 152.0 COG1487@1|root,COG1487@2|Bacteria,1N9J5@1224|Proteobacteria 1224|Proteobacteria S PIN domain - - - - - - - - - - - - PIN k59_1259682_1 1101195.Meth11DRAFT_0954 3.06e-34 132.0 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,2VH49@28216|Betaproteobacteria,2KKVZ@206350|Nitrosomonadales 206350|Nitrosomonadales G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB - - ko:K19804 - - - - ko00000 - - - TPR_16,TPR_7 k59_422765_1 290400.Jann_2166 4.4e-39 143.0 COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,2TT2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Belongs to the HpcH HpaI aldolase family hpcH - 4.1.2.20,4.1.2.52 ko:K01630,ko:K02510 ko00053,ko00350,ko01120,map00053,map00350,map01120 - R01645,R01647,R02754,R03277 RC00307,RC00435,RC00572,RC00574,RC03057 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_474855_1 1304284.L21TH_0106 2.47e-58 194.0 COG1929@1|root,COG1929@2|Bacteria,1TPSI@1239|Firmicutes,249SH@186801|Clostridia,36E78@31979|Clostridiaceae 186801|Clostridia G Belongs to the glycerate kinase type-1 family glxK - 2.7.1.165 ko:K00865 ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 - R08572 RC00002,RC00428 ko00000,ko00001,ko01000 - - - Gly_kinase k59_893071_1 260799.BAS4487 5.97e-57 189.0 COG0538@1|root,COG0538@2|Bacteria,1UHPE@1239|Firmicutes,4H9US@91061|Bacilli,1ZBWV@1386|Bacillus 91061|Bacilli C isocitrate icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_893071_2 270374.MELB17_13966 2.16e-74 236.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,464GC@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - 4.4.1.11 ko:K01761,ko:K10764 ko00270,ko00450,ko00920,ko01100,map00270,map00450,map00920,map01100 - R00654,R01288,R04770 RC00020,RC00196,RC00348,RC01209,RC01210,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_944711_1 1219375.CM002139_gene3503 6.1e-90 275.0 COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,1RP7G@1236|Gammaproteobacteria,1X3KP@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rmlB GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008460,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_1467850_1 595536.ADVE02000002_gene4118 1.99e-43 145.0 COG2801@1|root,COG2801@2|Bacteria,1NEIM@1224|Proteobacteria 1224|Proteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - - k59_1154017_1 1120998.AUFC01000001_gene1968 1.28e-38 137.0 COG4887@1|root,COG4887@2|Bacteria,1V4ZU@1239|Firmicutes,24CCD@186801|Clostridia 186801|Clostridia C Psort location Cytoplasmic, score - - - - - - - - - - - - DUF1847 k59_1049653_1 268746.Q58MK4_BPPRM 3.32e-97 308.0 4QERI@10239|Viruses,4QYA1@35237|dsDNA viruses no RNA stage,4QS5A@28883|Caudovirales,4QIAY@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_996998_1 710685.MycrhN_0147 4.26e-22 95.9 COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,2362Z@1762|Mycobacteriaceae 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_996998_2 1121272.KB903292_gene3982 4.29e-42 150.0 COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria,4DAUP@85008|Micromonosporales 201174|Actinobacteria IQ AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_474880_1 1415774.U728_29 1.16e-06 56.6 COG1408@1|root,COG1408@2|Bacteria,1UU17@1239|Firmicutes,25CIK@186801|Clostridia,36WWQ@31979|Clostridiaceae 186801|Clostridia S Calcineurin-like phosphoesterase superfamily domain - - - ko:K07098 - - - - ko00000 - - - Metallophos k59_1049654_1 331869.BAL199_12411 1.88e-40 144.0 COG1051@1|root,COG1051@2|Bacteria,1QUQ0@1224|Proteobacteria,2TXKI@28211|Alphaproteobacteria 28211|Alphaproteobacteria F NUDIX domain - - 2.7.6.2 ko:K00949 ko00730,ko01100,map00730,map01100 - R00619 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DUF4743,NUDIX k59_1049654_2 981384.AEYW01000006_gene2520 5.78e-73 240.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2U2E4@28211|Alphaproteobacteria,4NDQ0@97050|Ruegeria 28211|Alphaproteobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_944728_1 1283300.ATXB01000001_gene1286 6.66e-144 414.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1XEDQ@135618|Methylococcales 135618|Methylococcales F Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_944729_1 330214.NIDE2746 8.81e-79 241.0 COG0755@1|root,COG0755@2|Bacteria,3J14H@40117|Nitrospirae 40117|Nitrospirae O Cytochrome C assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_944729_2 330214.NIDE2745 1.76e-14 72.0 COG0373@1|root,COG0373@2|Bacteria,3J0BD@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_422795_1 765912.Thimo_2605 3.41e-69 223.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1WWPA@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase - - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_789542_1 519989.ECTPHS_11727 4.63e-52 184.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1WW2Y@135613|Chromatiales 135613|Chromatiales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_893100_1 349124.Hhal_1999 1.39e-77 246.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1WW3A@135613|Chromatiales 135613|Chromatiales F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_474893_1 570967.JMLV01000008_gene1335 2.55e-127 371.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TSBB@28211|Alphaproteobacteria,2JR85@204441|Rhodospirillales 204441|Rhodospirillales CE Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.83,1.1.1.93,4.1.1.73 ko:K07246 ko00630,ko00650,map00630,map00650 - R00215,R01751,R02545,R06180 RC00084,RC00105,RC00594 ko00000,ko00001,ko01000 - - - Iso_dh k59_1415222_1 1463936.JOJI01000001_gene1997 2.76e-41 152.0 COG0500@1|root,COG0500@2|Bacteria,2I2Y4@201174|Actinobacteria 201174|Actinobacteria Q o-methyltransferase - - 2.1.1.302 ko:K21377 - - - - ko00000,ko01000 - - - Dimerisation2,Methyltransf_2 k59_527115_1 63737.Npun_R2169 3.89e-65 212.0 COG0577@1|root,COG0577@2|Bacteria,1G20M@1117|Cyanobacteria,1HQXC@1161|Nostocales 1117|Cyanobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1571677_2 1218084.BBJK01000058_gene4460 1.37e-13 70.5 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2VI4S@28216|Betaproteobacteria,1K0NF@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the mannose-6-phosphate isomerase type 2 family algA - 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_422802_1 768671.ThimaDRAFT_1125 1.22e-70 225.0 COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria,1WWYR@135613|Chromatiales 135613|Chromatiales S PFAM Succinylglutamate desuccinylase Aspartoacylase - - - - - - - - - - - - AstE_AspA k59_422802_3 1137799.GZ78_18610 1.03e-10 59.7 COG0776@1|root,COG0776@2|Bacteria,1RFWH@1224|Proteobacteria,1SBVN@1236|Gammaproteobacteria,1XREE@135619|Oceanospirillales 135619|Oceanospirillales L Belongs to the bacterial histone-like protein family - - - - - - - - - - - - Bac_DNA_binding k59_474904_1 330214.NIDE4122 3.21e-69 233.0 COG0249@1|root,COG0249@2|Bacteria,3J0CE@40117|Nitrospirae 40117|Nitrospirae L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1310636_1 1229909.NSED_01700 8.53e-81 241.0 COG0195@1|root,arCOG01760@2157|Archaea,41SJQ@651137|Thaumarchaeota 651137|Thaumarchaeota K Participates in transcription termination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_2 k59_1310636_2 1229909.NSED_01705 4.75e-08 52.0 COG0048@1|root,arCOG04255@2157|Archaea,41SIB@651137|Thaumarchaeota 651137|Thaumarchaeota J With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits rps12 - - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_527122_2 1439940.BAY1663_02958 3.39e-89 276.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063,iJN746.PP_4889 Adenylsucc_synt k59_318751_2 444859.E3SIC4_9CAUD 1.56e-38 130.0 4QI4K@10662|Myoviridae 10662|Myoviridae S copper ion binding - - - - - - - - - - - - - k59_944757_1 1382358.JHVN01000013_gene1769 4.5e-141 408.0 COG0189@1|root,COG0189@2|Bacteria,1TSHN@1239|Firmicutes,4HBFG@91061|Bacilli 91061|Bacilli HJ COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) - - - - - - - - - - - - RimK k59_370581_1 1382304.JNIL01000001_gene317 3.79e-12 70.9 COG0346@1|root,COG2185@1|root,COG0346@2|Bacteria,COG2185@2|Bacteria,1V3QN@1239|Firmicutes,4IRRS@91061|Bacilli,2794J@186823|Alicyclobacillaceae 91061|Bacilli EI B12 binding domain - - 5.4.99.2 ko:K01849 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,Glyoxalase_4 k59_1049703_1 1141136.K4F7E6_9CAUD 1.86e-19 86.3 4QH9H@10239|Viruses,4QXST@35237|dsDNA viruses no RNA stage,4QTW5@28883|Caudovirales,4QKJS@10662|Myoviridae 10662|Myoviridae S kinase activity - - - - - - - - - - - - - k59_1207682_1 36809.MAB_2316 1.74e-57 198.0 COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria,23426@1762|Mycobacteriaceae 201174|Actinobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.7 ko:K15868 ko00121,map00121 - - - ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_1467947_1 266835.14024285 1.6e-69 219.0 COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2TSTD@28211|Alphaproteobacteria,43I92@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Belongs to the binding-protein-dependent transport system permease family - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_266204_1 754477.Q7C_2134 2.15e-66 211.0 2BVTQ@1|root,2Z7J9@2|Bacteria,1P01Z@1224|Proteobacteria,1RNNB@1236|Gammaproteobacteria,4603Z@72273|Thiotrichales 72273|Thiotrichales S Protein of unknown function (DUF2797) - - - - - - - - - - - - DUF2797 k59_108973_1 1123261.AXDW01000017_gene3163 0.000473 48.1 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,1RMYF@1236|Gammaproteobacteria,1X30X@135614|Xanthomonadales 135614|Xanthomonadales C COG2010 Cytochrome c, mono- and diheme variants - - - - - - - - - - - - Cytochrom_C k59_58360_1 391625.PPSIR1_34807 3.92e-121 365.0 COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria,4379P@68525|delta/epsilon subdivisions,2X9XU@28221|Deltaproteobacteria,2Z1Y1@29|Myxococcales 28221|Deltaproteobacteria S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_1467949_1 196367.JNFG01000017_gene4104 2.84e-15 77.8 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2VHBC@28216|Betaproteobacteria,1K0G3@119060|Burkholderiaceae 28216|Betaproteobacteria S Aminoglycoside phosphotransferase - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_1467949_2 1266925.JHVX01000003_gene596 2.37e-39 150.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,371ZN@32003|Nitrosomonadales 28216|Betaproteobacteria M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_213832_1 713586.KB900536_gene921 1.17e-61 213.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales 135613|Chromatiales Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_633014_2 1144343.PMI41_03484 1.06e-12 73.6 COG3209@1|root,COG3740@1|root,COG3209@2|Bacteria,COG3740@2|Bacteria,1N2D8@1224|Proteobacteria,2UD3U@28211|Alphaproteobacteria,43IST@69277|Phyllobacteriaceae 28211|Alphaproteobacteria M Caudovirus prohead serine protease gp35 - - ko:K06904 - - - - ko00000 - - - Peptidase_S78 k59_58367_1 391625.PPSIR1_01824 2.31e-37 137.0 COG1309@1|root,COG1309@2|Bacteria,1MUUY@1224|Proteobacteria,42VQ5@68525|delta/epsilon subdivisions,2WSX2@28221|Deltaproteobacteria,2YZU5@29|Myxococcales 28221|Deltaproteobacteria K WHG domain - - - - - - - - - - - - TetR_N,WHG k59_685140_1 1333998.M2A_0959 1.69e-90 273.0 COG0596@1|root,COG0596@2|Bacteria,1R4ZX@1224|Proteobacteria,2TU6R@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons dhaA - 3.8.1.5 ko:K01563 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_1473440_1 765914.ThisiDRAFT_1527 6.07e-200 558.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1WXC0@135613|Chromatiales 135613|Chromatiales G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_1158065_1 1026882.MAMP_00013 3.36e-40 150.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,45ZPB@72273|Thiotrichales 72273|Thiotrichales U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_1266306_1 472759.Nhal_3887 1.03e-70 234.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1WWYN@135613|Chromatiales 135613|Chromatiales U type IV pilus secretin PilQ - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_1001916_1 1123253.AUBD01000007_gene686 2.1e-89 286.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1X3DK@135614|Xanthomonadales 135614|Xanthomonadales J due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_1107208_1 1229909.NSED_01325 1.38e-105 324.0 COG1009@1|root,arCOG01539@2157|Archaea,41SC4@651137|Thaumarchaeota 651137|Thaumarchaeota C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_639602_1 1163407.UU7_01202 4.37e-38 141.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1X42D@135614|Xanthomonadales 135614|Xanthomonadales H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_218993_1 237609.PSAKL28_50390 1.53e-13 70.5 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the peptidase M20A family. ArgE subfamily argE GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0008777,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019752,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - iECUMN_1333.ECUMN_4488 M20_dimer,Peptidase_M20,Peptidase_M28 k59_218993_2 1049564.TevJSym_aw00630 5.27e-25 105.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J4C2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain ykoW - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_1576576_1 754477.Q7C_2315 4.35e-06 54.3 COG0810@1|root,COG2304@1|root,COG2931@1|root,COG0810@2|Bacteria,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - Cadherin_3,DUF4347,VWA_2 k59_1001928_1 931627.MycrhDRAFT_1491 2.24e-24 101.0 COG3384@1|root,COG3384@2|Bacteria,2GJDG@201174|Actinobacteria,232MJ@1762|Mycobacteriaceae 201174|Actinobacteria S Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - - - - - - - - - - LigB k59_639618_2 1462526.BN990_04478 8.33e-47 162.0 COG1136@1|root,COG1136@2|Bacteria,1TNZG@1239|Firmicutes,4H9UT@91061|Bacilli,4C6D5@84406|Virgibacillus 91061|Bacilli V ABC transporter yxdL_2 - - ko:K02003,ko:K11635 ko02020,map02020 M00258,M00315 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.134.6 - - ABC_tran k59_1629604_1 118005.AWNK01000011_gene159 4.1e-39 144.0 COG0282@1|root,COG0282@2|Bacteria 2|Bacteria F acetate kinase activity ackA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1034,iNJ661.Rv0409 Acetate_kinase k59_845853_1 237368.SCABRO_01870 3.89e-40 150.0 COG0043@1|root,COG0043@2|Bacteria,2IYCA@203682|Planctomycetes 203682|Planctomycetes H COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and - - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_113828_1 555778.Hneap_1715 1.4e-91 277.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1WWMZ@135613|Chromatiales 135613|Chromatiales E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1266344_1 316279.Syncc9902_2036 9.94e-143 409.0 2DBBD@1|root,2Z87P@2|Bacteria,1G08A@1117|Cyanobacteria,1GYWQ@1129|Synechococcus 1117|Cyanobacteria C Photosystem II (PSII) is a light-driven water plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1 D2 (PsbA PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors psbA2 - 1.10.3.9 ko:K02703 ko00195,ko01100,map00195,map01100 M00161 - - ko00000,ko00001,ko00002,ko00194,ko01000 - - - Photo_RC k59_532202_1 1191523.MROS_2302 2.55e-28 105.0 COG0799@1|root,COG0799@2|Bacteria 2|Bacteria S negative regulation of ribosome biogenesis rsfS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 2.7.7.18 ko:K00969,ko:K09710 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03009 - - - RsfS k59_639631_1 2340.JV46_05690 2.78e-82 254.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L L COG2826 Transposase and inactivated derivatives, IS30 family insI GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K07482 - - - - ko00000 - - - HTH_38,rve k59_1420789_1 648757.Rvan_3136 1.81e-26 106.0 COG4186@1|root,COG4186@2|Bacteria,1RD94@1224|Proteobacteria,2U7MY@28211|Alphaproteobacteria,3N946@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S Phosphoesterase or phosphohydrolase - - - - - - - - - - - - Metallophos,Metallophos_2 k59_796573_1 1121396.KB893104_gene1783 1.8e-50 176.0 28J8Y@1|root,2Z943@2|Bacteria,1REXC@1224|Proteobacteria,43DCS@68525|delta/epsilon subdivisions,2X8IT@28221|Deltaproteobacteria,2MK0X@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF4338) - - - - - - - - - - - - DUF4338 k59_1368185_2 1496688.ER33_15295 2.43e-08 53.5 2A1SJ@1|root,30Q19@2|Bacteria,1GJH3@1117|Cyanobacteria,22TVM@167375|Cyanobium 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_1368185_3 444860.E3SIY9_9CAUD 7.72e-66 202.0 4QB1K@10239|Viruses,4QUUK@35237|dsDNA viruses no RNA stage,4QPBK@28883|Caudovirales,4QI9B@10662|Myoviridae 10662|Myoviridae S Gene 25-like lysozyme - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098025 - - - - - - - - - - - k59_639637_1 247634.GPB2148_2162 2.15e-46 158.0 COG3917@1|root,COG3917@2|Bacteria,1RJFB@1224|Proteobacteria,1S772@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q 2-hydroxychromene-2-carboxylate isomerase - - - - - - - - - - - - DSBA k59_480692_2 436308.Nmar_0804 2.03e-80 243.0 COG0092@1|root,arCOG04097@2157|Archaea,41SIM@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds the lower part of the 30S subunit head rps3 - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_427984_1 626887.J057_08786 8.16e-09 63.5 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,4650G@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1576609_1 444860.E3SJ11_9CAUD 3.87e-101 296.0 4QAWI@10239|Viruses,4QW40@35237|dsDNA viruses no RNA stage,4QPUX@28883|Caudovirales,4QINW@10662|Myoviridae 10662|Myoviridae S Pfam:Peptidase_S77 - - - - - - - - - - - - - k59_1629625_1 1278073.MYSTI_04828 4.78e-58 196.0 COG2124@1|root,COG2124@2|Bacteria,1MV8Q@1224|Proteobacteria,438NC@68525|delta/epsilon subdivisions,2X3WD@28221|Deltaproteobacteria,2YXBV@29|Myxococcales 28221|Deltaproteobacteria C Cytochrome P450 - - 1.14.13.151,1.14.15.14 ko:K05525,ko:K20497 ko00902,ko01110,map00902,map01110 - R04366,R09922,R09923,R09924,R09925 RC01137,RC02561,RC02626 ko00000,ko00001,ko00199,ko01000 - - - p450 k59_1266368_1 317025.Tcr_1284 1.8e-66 212.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,45ZY5@72273|Thiotrichales 72273|Thiotrichales J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_1521604_1 1190606.AJYG01000049_gene1210 6.95e-21 91.3 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,1XU2Z@135623|Vibrionales 135623|Vibrionales U COG1115 Na alanine symporter - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_1521604_2 314285.KT71_09247 1.17e-36 134.0 COG4221@1|root,COG4221@2|Bacteria,1R83E@1224|Proteobacteria,1T1UP@1236|Gammaproteobacteria,1JABR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S KR domain - - - - - - - - - - - - adh_short k59_796592_1 103690.17134335 9.5e-05 47.4 COG4671@1|root,COG4671@2|Bacteria,1G0X1@1117|Cyanobacteria,1HNIA@1161|Nostocales 1117|Cyanobacteria S PFAM Glycosyltransferase family 28 C-terminal domain - - - - - - - - - - - iJN678.sll1722 Glyco_tran_28_C k59_1266369_1 1380394.JADL01000001_gene2792 3.52e-111 332.0 COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,2JPME@204441|Rhodospirillales 204441|Rhodospirillales KQ helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20,HTH_5,Methyltransf_11 k59_1576610_1 1184267.A11Q_2346 3.9e-29 124.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein - - - - - - - - - - - - Fer4_12,SPASM k59_164711_1 305900.GV64_02665 6.55e-102 304.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1XHX5@135619|Oceanospirillales 135619|Oceanospirillales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_845868_1 1121033.AUCF01000027_gene2732 3.6e-59 190.0 COG1335@1|root,COG1335@2|Bacteria,1RE3C@1224|Proteobacteria,2U0GC@28211|Alphaproteobacteria,2JSP8@204441|Rhodospirillales 204441|Rhodospirillales Q COG1335 Amidases related to nicotinamidase - - - - - - - - - - - - Isochorismatase k59_845868_2 583355.Caka_2310 3.32e-38 130.0 COG3837@1|root,COG3837@2|Bacteria 2|Bacteria S Cupin domain - - 3.4.13.22 ko:K08641,ko:K11312 ko01502,ko02020,map01502,map02020 M00651 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 - - - Cupin_2,HTH_18 k59_845868_3 102232.GLO73106DRAFT_00001180 1.47e-35 128.0 2BCFE@1|root,32611@2|Bacteria,1G6WH@1117|Cyanobacteria 1117|Cyanobacteria S Bacterial PH domain - - - - - - - - - - - - bPH_5 k59_845868_4 2340.JV46_04030 3.28e-87 263.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,1S237@1236|Gammaproteobacteria,1J9MC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Reversible hydration of carbon dioxide cynT - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_845868_5 580332.Slit_2775 9.6e-35 130.0 COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,2VUQP@28216|Betaproteobacteria 28216|Betaproteobacteria IQ PFAM Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short k59_1474433_1 1288494.EBAPG3_2310 5.71e-59 205.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,2VHS4@28216|Betaproteobacteria,3743Q@32003|Nitrosomonadales 28216|Betaproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide - - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_427988_1 292415.Tbd_0077 0.0 920.0 COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2VHSF@28216|Betaproteobacteria,1KS6X@119069|Hydrogenophilales 119069|Hydrogenophilales C Cytochrome D1 heme domain - - 1.7.2.1,1.7.99.1 ko:K15864 ko00910,ko01120,map00910,map01120 M00529 R00143,R00783,R00785 RC00086,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_D1,Cytochrome_CBB3 k59_1474434_1 1125863.JAFN01000001_gene1123 2.18e-65 213.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_1107257_2 1123368.AUIS01000001_gene1984 1.8e-37 132.0 COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,1SH5E@1236|Gammaproteobacteria,2NC54@225057|Acidithiobacillales 225057|Acidithiobacillales I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_741159_1 292459.STH2817 9.19e-74 241.0 COG1215@1|root,COG1215@2|Bacteria,1UYDS@1239|Firmicutes,25BCG@186801|Clostridia 186801|Clostridia M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_741159_2 1121939.L861_01745 3.01e-93 276.0 COG1765@1|root,COG1765@2|Bacteria,1QUE7@1224|Proteobacteria,1S84Z@1236|Gammaproteobacteria,1XKED@135619|Oceanospirillales 135619|Oceanospirillales O OsmC-like protein - - - - - - - - - - - - OsmC k59_1001976_1 1323663.AROI01000035_gene1395 1.19e-69 224.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria 1236|Gammaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ GO:0006457,GO:0008150,GO:0009987 - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1368209_1 1405.DJ92_4103 2.6e-17 86.3 COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,4H9SA@91061|Bacilli,1ZAXY@1386|Bacillus 91061|Bacilli M penicillin-binding protein pbp2A - 2.4.1.129,3.4.16.4 ko:K12555 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_690987_1 95619.PM1_0221305 7.31e-12 65.1 COG1024@1|root,COG1024@2|Bacteria,1RAAV@1224|Proteobacteria,1RRTJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Enoyl-CoA hydratase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_690987_2 1161401.ASJA01000012_gene808 5.22e-17 82.8 COG3544@1|root,COG3544@2|Bacteria,1NTI3@1224|Proteobacteria,2UMCM@28211|Alphaproteobacteria,43Z3F@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF305) - - - - - - - - - - - - DUF305 k59_1576630_1 1166018.FAES_4065 1.85e-29 119.0 2C4HH@1|root,33XVS@2|Bacteria,4P2Z3@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1576630_2 1300345.LF41_2407 5.81e-17 82.8 2EES9@1|root,338JX@2|Bacteria 2|Bacteria L RNase_H superfamily - - - - - - - - - - - - RNase_H_2 k59_375978_1 765911.Thivi_3047 2.76e-35 135.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1WWYU@135613|Chromatiales 135613|Chromatiales P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3333 k59_691004_1 1116472.MGMO_88c00180 5.53e-09 63.5 COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,1S3FX@1236|Gammaproteobacteria,1XDS4@135618|Methylococcales 135618|Methylococcales S Protein conserved in bacteria - - - - - - - - - - - - - k59_796639_1 362976.HQ_2652A 3.27e-10 65.9 COG0187@1|root,arCOG04371@2157|Archaea,2XSVX@28890|Euryarchaeota,23THF@183963|Halobacteria 183963|Halobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_480745_2 388467.A19Y_2873 1.04e-72 241.0 COG2303@1|root,COG2303@2|Bacteria,1G3V7@1117|Cyanobacteria,1H9T9@1150|Oscillatoriales 1117|Cyanobacteria E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_65157_1 1105110.MC5_06210 2.81e-91 278.0 COG0708@1|root,COG0708@2|Bacteria,1MVMC@1224|Proteobacteria,2TRWQ@28211|Alphaproteobacteria,47F4V@766|Rickettsiales 766|Rickettsiales L Endonuclease/Exonuclease/phosphatase family xth1 - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_898329_1 290317.Cpha266_1345 7.35e-23 103.0 29M6H@1|root,3083Y@2|Bacteria,1FEEU@1090|Chlorobi 1090|Chlorobi - - - - - - - - - - - - - - - k59_428023_1 1121373.KB903654_gene1536 1.66e-19 90.5 COG2253@1|root,COG2253@2|Bacteria,4NME0@976|Bacteroidetes,47SE1@768503|Cytophagia 976|Bacteroidetes S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii k59_480749_1 396588.Tgr7_1535 1.79e-129 394.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_796651_2 697282.Mettu_0781 4.46e-19 84.3 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1XEKQ@135618|Methylococcales 135618|Methylococcales H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0044271,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas k59_219081_2 1535422.ND16A_2692 2.09e-21 94.4 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,2Q646@267889|Colwelliaceae 1236|Gammaproteobacteria C Cytochrome c cc4 - - - - - - - - - - - Cytochrom_C k59_639723_1 573569.F7308_0537 7.2e-10 60.8 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,45ZQ9@72273|Thiotrichales 72273|Thiotrichales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_639723_2 228410.NE1771 1.15e-31 127.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,372H6@32003|Nitrosomonadales 28216|Betaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1474495_1 1265310.CCBD010000059_gene1317 2.49e-08 54.7 COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,234BM@1762|Mycobacteriaceae 201174|Actinobacteria C acyl-CoA dehydrogenase fadE17 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1474495_2 1030157.AFMP01000031_gene2999 5.01e-75 239.0 COG4638@1|root,COG4638@2|Bacteria,1N3CA@1224|Proteobacteria,2VG2K@28211|Alphaproteobacteria,2K2PB@204457|Sphingomonadales 204457|Sphingomonadales P Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_1002039_1 330214.NIDE1926 1.07e-48 160.0 COG3794@1|root,COG3794@2|Bacteria 2|Bacteria C PFAM blue (type 1) copper domain protein amcY GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Copper-bind,Cupredoxin_1 k59_164774_2 870187.Thini_2281 5.92e-117 352.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,1RSCT@1236|Gammaproteobacteria,4624S@72273|Thiotrichales 72273|Thiotrichales C Aldehyde ferredoxin oxidoreductase, N-terminal domain - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_324216_1 123214.PERMA_1115 3.11e-38 137.0 COG0414@1|root,COG0414@2|Bacteria,2G3TD@200783|Aquificae 200783|Aquificae H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_324216_2 287986.DV20_20155 4.17e-11 60.8 COG0853@1|root,COG0853@2|Bacteria,2IHTC@201174|Actinobacteria,4E2JG@85010|Pseudonocardiales 201174|Actinobacteria H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD GO:0003674,GO:0003824,GO:0004068,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006523,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0030312,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox k59_1368270_1 1229909.NSED_05735 3.5e-21 87.0 COG0589@1|root,arCOG02053@2157|Archaea,41TB2@651137|Thaumarchaeota 651137|Thaumarchaeota T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp k59_1368270_2 436308.Nmar_0995 1.1e-65 202.0 COG0225@1|root,arCOG02816@2157|Archaea,41SMP@651137|Thaumarchaeota 651137|Thaumarchaeota O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_272195_1 1254432.SCE1572_28450 1.14e-60 202.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42RS8@68525|delta/epsilon subdivisions,2WND0@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Group II intron maturase-specific domain protein - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - Cas_Cas1,GIIM,RVT_1 k59_1316191_1 1469245.JFBG01000046_gene2241 1.17e-102 326.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WXAN@135613|Chromatiales 135613|Chromatiales C FAD linked oxidases, C-terminal domain - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_324914_1 269799.Gmet_0588 8.01e-10 68.6 COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria,43TXB@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8 k59_324914_2 448385.sce4720 2.32e-12 71.2 COG1858@1|root,COG2706@1|root,COG3391@1|root,COG1858@2|Bacteria,COG2706@2|Bacteria,COG3391@2|Bacteria,1R66T@1224|Proteobacteria,438GV@68525|delta/epsilon subdivisions,2X3RP@28221|Deltaproteobacteria,2YWY2@29|Myxococcales 28221|Deltaproteobacteria P cytochrome C peroxidase - - - - - - - - - - - - - k59_1164672_1 1121937.AUHJ01000002_gene3523 3.88e-68 221.0 COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,1RMHA@1236|Gammaproteobacteria,464JE@72275|Alteromonadaceae 1236|Gammaproteobacteria N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 k59_122748_1 492774.JQMB01000005_gene5038 1.97e-89 287.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,4B8TC@82115|Rhizobiaceae 28211|Alphaproteobacteria E Belongs to the GcvT family Sardh GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006575,GO:0006576,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008480,GO:0009056,GO:0009063,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019695,GO:0019752,GO:0019842,GO:0031406,GO:0031974,GO:0033218,GO:0034641,GO:0035999,GO:0036094,GO:0042133,GO:0042135,GO:0042219,GO:0042402,GO:0042426,GO:0042558,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046483,GO:0046653,GO:0046997,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072341,GO:0097159,GO:0097164,GO:1901052,GO:1901053,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.5.3.19 ko:K19191 ko00760,ko01120,map00760,map01120 - R10102 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO,FAO_M,GCV_T,GCV_T_C k59_171718_1 443144.GM21_0105 1.77e-68 226.0 COG2010@1|root,COG5557@1|root,COG2010@2|Bacteria,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42PIE@68525|delta/epsilon subdivisions,2WM3C@28221|Deltaproteobacteria,43SBI@69541|Desulfuromonadales 28221|Deltaproteobacteria C Polysulphide reductase, NrfD moz - - ko:K00185 - - - - ko00000 5.A.3 - - DUF3341,NrfD k59_331432_1 877424.ATWC01000001_gene2050 1.42e-05 50.8 COG2423@1|root,COG2423@2|Bacteria,1UQHC@1239|Firmicutes,25895@186801|Clostridia,27JMW@186928|unclassified Lachnospiraceae 186801|Clostridia E Ornithine cyclodeaminase/mu-crystallin family - - - - - - - - - - - - OCD_Mu_crystall k59_649224_1 1161401.ASJA01000001_gene236 4.1e-22 101.0 COG2304@1|root,COG2304@2|Bacteria,1PBVT@1224|Proteobacteria,2U3NK@28211|Alphaproteobacteria,43YWS@69657|Hyphomonadaceae 28211|Alphaproteobacteria S von Willebrand factor (vWF) type A domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA,VWA_2 k59_1637568_1 743720.Psefu_0428 2.49e-75 236.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1YWNV@136845|Pseudomonas putida group 1236|Gammaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB GO:0000166,GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3389,iBWG_1329.BWG_3080,iECDH10B_1368.ECDH10B_3564,iECDH1ME8569_1439.ECDH1ME8569_3268,iECNA114_1301.ECNA114_3486,iEcDH1_1363.EcDH1_0324,iJO1366.b3389,iJR904.b3389,iY75_1357.Y75_RS20275 DHQ_synthase k59_1637568_2 871585.BDGL_002656 1.46e-54 178.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,3NJ5H@468|Moraxellaceae 1236|Gammaproteobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_698314_1 290398.Csal_0021 5.93e-35 127.0 COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,1S612@1236|Gammaproteobacteria,1XJPQ@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig k59_331448_1 330214.NIDE3360 1.97e-11 69.3 COG0823@1|root,COG0823@2|Bacteria,3J0U9@40117|Nitrospirae 40117|Nitrospirae U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 k59_1276182_1 1336243.JAEA01000006_gene329 5.3e-45 163.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria,1JX4A@119045|Methylobacteriaceae 28211|Alphaproteobacteria O Peptidase family M41 - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_853262_1 314287.GB2207_09311 2.14e-68 223.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1RMSA@1236|Gammaproteobacteria,1J4VD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U MotA TolQ ExbB proton channel family protein - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_74599_1 472759.Nhal_3293 5.61e-16 80.9 COG3291@1|root,COG4733@1|root,COG3291@2|Bacteria,COG4733@2|Bacteria,1R0I3@1224|Proteobacteria,1T4IC@1236|Gammaproteobacteria,1WYCZ@135613|Chromatiales 135613|Chromatiales S PFAM Fibronectin type III - - - - - - - - - - - - fn3 k59_74599_2 1123392.AQWL01000004_gene2579 5.7e-55 177.0 COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,2VQ3T@28216|Betaproteobacteria,1KSM7@119069|Hydrogenophilales 119069|Hydrogenophilales L Uracil DNA glycosylase superfamily - - - - - - - - - - - - UDG k59_122792_2 1192034.CAP_2685 1.5e-12 64.3 COG0346@1|root,COG0346@2|Bacteria,1RH4C@1224|Proteobacteria,431XP@68525|delta/epsilon subdivisions,2WWM1@28221|Deltaproteobacteria,2Z0KY@29|Myxococcales 28221|Deltaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_331455_1 1232410.KI421413_gene574 1.67e-11 70.1 COG1404@1|root,COG1520@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,1MU3S@1224|Proteobacteria,42SPI@68525|delta/epsilon subdivisions 1224|Proteobacteria O COG1404 Subtilisin-like serine proteases - - 3.4.21.111 ko:K12685,ko:K20754 - - - - ko00000,ko01000,ko01002,ko02000,ko02044 1.B.12.5.1,1.B.12.5.3 - - Inhibitor_I9,Peptidase_S8 k59_1430294_1 1255043.TVNIR_1306 4.76e-73 238.0 COG3118@1|root,COG3118@2|Bacteria 2|Bacteria O belongs to the thioredoxin family ybbN GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K03671,ko:K05838 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_698328_1 425104.Ssed_1136 1.53e-52 179.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,2Q9DF@267890|Shewanellaceae 1236|Gammaproteobacteria P ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA GO:0003674,GO:0005215,GO:0005451,GO:0005488,GO:0005543,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006873,GO:0006875,GO:0006883,GO:0006885,GO:0006950,GO:0006970,GO:0008150,GO:0008289,GO:0008324,GO:0009628,GO:0009651,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0035725,GO:0042592,GO:0043157,GO:0043167,GO:0043168,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051453,GO:0055065,GO:0055067,GO:0055078,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1901611,GO:1901612,GO:1902600 - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - iSF_1195.SF0016,iSFxv_1172.SFxv_0017,iS_1188.S0018 Na_H_antiport_1 k59_1009563_1 1089545.KB913037_gene7305 9.58e-71 242.0 COG1361@1|root,COG4935@1|root,COG1361@2|Bacteria,COG4935@2|Bacteria,2I2W6@201174|Actinobacteria,4EDRS@85010|Pseudonocardiales 201174|Actinobacteria MO Proprotein convertase P-domain - - - - - - - - - - - - P_proprotein,Peptidase_S8 k59_74611_1 519989.ECTPHS_12423 2.17e-102 306.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,1RMHP@1236|Gammaproteobacteria,1WW13@135613|Chromatiales 135613|Chromatiales L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_7970_1 1004785.AMBLS11_16595 2.24e-28 113.0 COG3221@1|root,COG3221@2|Bacteria,1R4SK@1224|Proteobacteria,1RR7M@1236|Gammaproteobacteria,467E5@72275|Alteromonadaceae 1236|Gammaproteobacteria P ABC-type phosphate phosphonate transport system, periplasmic component - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_7970_2 640081.Dsui_2999 1.88e-17 85.5 COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,2WGMB@28216|Betaproteobacteria,2KZXX@206389|Rhodocyclales 1224|Proteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_698336_1 462590.A9J580_BPPYU 4.55e-83 266.0 4QB49@10239|Viruses,4QUZD@35237|dsDNA viruses no RNA stage,4QPU2@28883|Caudovirales,4QKRQ@10699|Siphoviridae 10699|Siphoviridae S Domain of unknown function (DUF4055) - - - - - - - - - - - - - k59_1584153_1 1229909.NSED_00010 1.72e-13 68.9 COG0423@1|root,arCOG00405@2157|Archaea,41S8S@651137|Thaumarchaeota 651137|Thaumarchaeota J synthetase (class II) - - 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b k59_1584153_2 436308.Nmar_0064 1.97e-75 232.0 COG0648@1|root,arCOG01894@2157|Archaea,41SDW@651137|Thaumarchaeota 651137|Thaumarchaeota L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo - 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 k59_74623_1 455632.SGR_6560 4.76e-11 65.1 COG0642@1|root,COG2205@2|Bacteria,2GIV9@201174|Actinobacteria,41BS5@629295|Streptomyces griseus group 201174|Actinobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_74623_2 1125863.JAFN01000001_gene746 1.12e-13 71.6 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Y98@68525|delta/epsilon subdivisions,2WTXU@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_385092_1 861299.J421_2767 7.93e-102 328.0 COG0085@1|root,COG0085@2|Bacteria,1ZSQH@142182|Gemmatimonadetes 142182|Gemmatimonadetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_698342_1 272624.lpg1034 2.43e-06 47.8 COG4244@1|root,COG4244@2|Bacteria,1NB74@1224|Proteobacteria,1SI9C@1236|Gammaproteobacteria,1JEFS@118969|Legionellales 118969|Legionellales S Predicted membrane protein (DUF2231) - - - - - - - - - - - - DUF2231 k59_74626_1 497321.C664_10058 1.03e-54 182.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2VHF7@28216|Betaproteobacteria,2KUT9@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_905732_1 1291050.JAGE01000001_gene2157 7.14e-44 164.0 COG1067@1|root,COG1067@2|Bacteria,1TQT5@1239|Firmicutes,248NE@186801|Clostridia,3WI8I@541000|Ruminococcaceae 186801|Clostridia O Belongs to the peptidase S16 family - - - - - - - - - - - - AAA_32,Lon_C k59_649303_1 1123257.AUFV01000002_gene2680 1.67e-70 240.0 COG0664@1|root,COG1033@1|root,COG0664@2|Bacteria,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1X3P5@135614|Xanthomonadales 135614|Xanthomonadales T Sterol-sensing domain of SREBP cleavage-activation - - - - - - - - - - - - MMPL,cNMP_binding k59_1009593_2 246200.SPO2711 9e-17 80.1 COG1804@1|root,COG1853@1|root,COG1804@2|Bacteria,COG1853@2|Bacteria,1MU2K@1224|Proteobacteria,2V8QS@28211|Alphaproteobacteria,4ND14@97050|Ruegeria 28211|Alphaproteobacteria C Flavin reductase like domain - - - - - - - - - - - - CoA_transf_3,Flavin_Reduct k59_957011_1 396588.Tgr7_0041 9.63e-83 256.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1WVUW@135613|Chromatiales 135613|Chromatiales E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_806407_1 768671.ThimaDRAFT_0679 1.67e-67 230.0 COG3387@1|root,COG3387@2|Bacteria,1MW9J@1224|Proteobacteria,1T2G2@1236|Gammaproteobacteria,1WWTU@135613|Chromatiales 135613|Chromatiales G PFAM Glycoside hydrolase 15-related - - - - - - - - - - - - F5_F8_type_C k59_1164724_1 762376.AXYL_04967 1.08e-58 196.0 COG2124@1|root,COG2124@2|Bacteria,1MV8Q@1224|Proteobacteria,2VN4A@28216|Betaproteobacteria 28216|Betaproteobacteria C cytochrome P450 - - - - - - - - - - - - p450 k59_1164724_2 1273125.Rrhod_2054 9.85e-22 99.4 COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4FV5K@85025|Nocardiaceae 201174|Actinobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_698365_1 330214.NIDE1728 6.95e-12 67.0 COG0443@1|root,COG0443@2|Bacteria,3J0D2@40117|Nitrospirae 40117|Nitrospirae O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_698365_2 9707.XP_004410574.1 6.62e-12 65.9 COG0484@1|root,KOG0550@2759|Eukaryota,38CD1@33154|Opisthokonta,3BAMR@33208|Metazoa,3CY9P@33213|Bilateria,48BGK@7711|Chordata,496I4@7742|Vertebrata,3JBUT@40674|Mammalia,3ER4Z@33554|Carnivora 33208|Metazoa O homolog subfamily C member 7 DNAJC7 GO:0001671,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008047,GO:0008150,GO:0009987,GO:0030234,GO:0031072,GO:0031974,GO:0031981,GO:0032781,GO:0043085,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043462,GO:0044093,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0051082,GO:0051084,GO:0051085,GO:0051336,GO:0051345,GO:0060589,GO:0060590,GO:0061077,GO:0065007,GO:0065009,GO:0070013,GO:0080134,GO:0080135,GO:0098772,GO:1900034 - ko:K09527 - - - - ko00000,ko03110 - - - DnaJ,TPR_1,TPR_16,TPR_2,TPR_8 k59_1164725_1 1122135.KB893135_gene1031 2.08e-68 225.0 28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,2TUAV@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_385139_1 861299.J421_1415 1.25e-67 219.0 COG0577@1|root,COG0577@2|Bacteria,1ZUG3@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1430363_1 1249627.D779_1787 2.27e-146 440.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales 135613|Chromatiales K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_1164732_1 1333998.M2A_0327 9.06e-33 120.0 COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,2U69V@28211|Alphaproteobacteria,4BRYX@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Protein of unknown function (DUF3501) - - - - - - - - - - - - DUF3501 k59_957031_1 666685.R2APBS1_1019 1.88e-40 138.0 COG3296@1|root,COG3296@2|Bacteria,1N8TC@1224|Proteobacteria,1SEZY@1236|Gammaproteobacteria,1X76D@135614|Xanthomonadales 135614|Xanthomonadales S Domain of unknown function (DUF4870) - - - ko:K09940 - - - - ko00000 - - - DUF4870 k59_957031_2 105559.Nwat_0409 3.14e-76 236.0 COG0500@1|root,COG2226@2|Bacteria,1RDI3@1224|Proteobacteria,1S423@1236|Gammaproteobacteria,1WWQ9@135613|Chromatiales 135613|Chromatiales Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_23,Methyltransf_25 k59_1277413_1 378806.STAUR_6427 1.75e-15 81.6 COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1REF1@1224|Proteobacteria,42Q4N@68525|delta/epsilon subdivisions,2WS51@28221|Deltaproteobacteria,2YWNR@29|Myxococcales 28221|Deltaproteobacteria O Fibronectin type 3 domain - - - - - - - - - - - - Peptidase_M6,Peptidase_S8 k59_749346_1 5141.EFNCRP00000006697 1.61e-10 67.0 COG1404@1|root,KOG1153@2759|Eukaryota,38H6S@33154|Opisthokonta,3NU05@4751|Fungi,3QR0F@4890|Ascomycota,211EN@147550|Sordariomycetes,3UAY3@5139|Sordariales,3UKUU@5148|Sordariaceae 4751|Fungi O Peptidase inhibitor I9 SUB2 - - - - - - - - - - - Inhibitor_I9,Peptidase_S8 k59_1277419_1 105559.Nwat_0559 1.62e-116 344.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_854180_1 713586.KB900536_gene699 5.82e-56 189.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1SYV1@1236|Gammaproteobacteria,1X2IS@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_75811_1 713586.KB900536_gene826 1.55e-05 45.8 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_75811_2 187272.Mlg_1095 3.49e-69 219.0 COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,1S9RP@1236|Gammaproteobacteria,1WZQP@135613|Chromatiales 135613|Chromatiales D Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division - - - ko:K14160 - - - - ko00000,ko03400 - - - SulA k59_75811_3 1380387.JADM01000009_gene3149 2.44e-14 77.8 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,1S28B@1236|Gammaproteobacteria,1XKB0@135619|Oceanospirillales 135619|Oceanospirillales L nucleotidyltransferase DNA polymerase involved in DNA repair - - - ko:K14161 - - - - ko00000,ko03400 - - - IMS k59_749352_1 391589.RGAI101_2664 4.77e-21 93.6 COG1024@1|root,COG1024@2|Bacteria,1N2V7@1224|Proteobacteria,2U4VQ@28211|Alphaproteobacteria,2P312@2433|Roseobacter 28211|Alphaproteobacteria I COG1024 Enoyl-CoA hydratase carnithine racemase - - - - - - - - - - - - ECH_1 k59_1222886_1 1463887.KL590001_gene5597 1.15e-27 115.0 COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria 201174|Actinobacteria M PFAM Glycosyl transferase, group 1 pimB - 2.4.1.346 ko:K13668 - - R11703,R11704 - ko00000,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_957841_1 1196323.ALKF01000166_gene443 2.26e-24 106.0 COG1331@1|root,COG1331@2|Bacteria,1TPRD@1239|Firmicutes,4H9ZS@91061|Bacilli,26R4I@186822|Paenibacillaceae 91061|Bacilli O Highly conserved protein containing a thioredoxin domain yyaL - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Glyco_hydro_9,Thioredox_DsbH k59_1063543_1 330214.NIDE2042 4.6e-41 145.0 COG0547@1|root,COG0547@2|Bacteria,3J0HE@40117|Nitrospirae 40117|Nitrospirae E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_1063543_2 330214.NIDE2043 2.51e-22 93.2 COG0134@1|root,COG0134@2|Bacteria,3J0NT@40117|Nitrospirae 40117|Nitrospirae E Indole-3-glycerol phosphate synthase trpC - 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS k59_854185_1 269798.CHU_3259 4.06e-11 66.2 COG3210@1|root,COG3210@2|Bacteria,4P1PQ@976|Bacteroidetes 976|Bacteroidetes U domain, Protein - - - - - - - - - - - - - k59_1010490_1 684949.ATTJ01000001_gene701 3.66e-73 237.0 COG0366@1|root,COG0366@2|Bacteria,1WIU5@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G PFAM alpha amylase, catalytic - - 3.2.1.133,3.2.1.135,3.2.1.54 ko:K01208 ko00500,ko01100,map00500,map01100 - R02112,R03122,R11262 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3459,Malt_amylase_C k59_1115445_1 382464.ABSI01000011_gene2990 2.95e-11 67.4 COG1968@1|root,COG1968@2|Bacteria,46SP6@74201|Verrucomicrobia,2IURU@203494|Verrucomicrobiae 203494|Verrucomicrobiae V Bacitracin resistance protein BacA uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_386310_1 991905.SL003B_2331 8.21e-81 247.0 COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,2TSAI@28211|Alphaproteobacteria,4BQ9P@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O Cytochrome C biogenesis protein transmembrane region ccdA - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD k59_650490_1 1448389.BAVQ01000023_gene1510 4.46e-06 50.4 COG5517@1|root,COG5517@2|Bacteria,2II1F@201174|Actinobacteria 201174|Actinobacteria Q SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_279925_1 246200.SPO0560 5.32e-27 110.0 COG0747@1|root,COG0747@2|Bacteria,1MU3P@1224|Proteobacteria,2TT4M@28211|Alphaproteobacteria,4NBG0@97050|Ruegeria 28211|Alphaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1222900_1 444860.E3SJ54_9CAUD 2.21e-56 192.0 4QDUC@10239|Viruses,4QV7K@35237|dsDNA viruses no RNA stage,4QR22@28883|Caudovirales,4QJ6D@10662|Myoviridae 10662|Myoviridae S transferase activity - - - - - - - - - - - - - k59_124032_1 765914.ThisiDRAFT_0356 5.35e-93 279.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,1WW7W@135613|Chromatiales 135613|Chromatiales E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_386323_1 685727.REQ_13820 2.66e-114 345.0 COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria,4FUVB@85025|Nocardiaceae 201174|Actinobacteria Q cytochrome P450 cyp51 GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0008398,GO:0016125,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0032451,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046906,GO:0048037,GO:0055114,GO:0070988,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901615 1.14.13.70 ko:K05917 ko00100,ko01100,ko01110,ko01130,map00100,map01100,map01110,map01130 M00101 R05640,R05731 RC01442 ko00000,ko00001,ko00002,ko00199,ko01000 - - - p450 k59_1063559_1 43354.JOIJ01000002_gene4438 2.32e-72 232.0 COG1960@1|root,COG1960@2|Bacteria,2GJDT@201174|Actinobacteria,4E2HV@85010|Pseudonocardiales 201174|Actinobacteria I Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1063559_2 1223545.GS4_36_00130 4.34e-17 80.5 COG1960@1|root,COG1960@2|Bacteria,2GIXS@201174|Actinobacteria,4GB0G@85026|Gordoniaceae 201174|Actinobacteria I Acyl-CoA dehydrogenase, middle domain fadE29 GO:0000166,GO:0003674,GO:0005488,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016125,GO:0016127,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044110,GO:0044116,GO:0044117,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0046164,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0051704,GO:0055114,GO:0071704,GO:0071949,GO:0072329,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652 - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1376213_1 227377.CBU_0548 2.17e-15 78.6 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1JCNE@118969|Legionellales 118969|Legionellales M Transglycosylase SLT domain mltB_2 - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_1376213_2 765913.ThidrDRAFT_0189 4.38e-36 132.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1WWAV@135613|Chromatiales 135613|Chromatiales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_1485173_1 700598.Niako_2072 4.34e-11 64.7 COG1680@1|root,COG1680@2|Bacteria,4NHJN@976|Bacteroidetes 976|Bacteroidetes V COG1680 Beta-lactamase class C and other penicillin binding - - - - - - - - - - - - Beta-lactamase k59_1485173_2 1089544.KB912942_gene7643 9.21e-64 213.0 COG1793@1|root,COG1793@2|Bacteria,2GJ2P@201174|Actinobacteria,4DXPV@85010|Pseudonocardiales 201174|Actinobacteria L DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair lig GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 ko:K10747 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N k59_1063565_1 472759.Nhal_1689 1.45e-76 255.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1WXAA@135613|Chromatiales 135613|Chromatiales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_650518_1 1125863.JAFN01000001_gene3326 2.16e-94 293.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,42M3D@68525|delta/epsilon subdivisions,2WJEA@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_75860_1 102232.GLO73106DRAFT_00001180 1.37e-34 124.0 2BCFE@1|root,32611@2|Bacteria,1G6WH@1117|Cyanobacteria 1117|Cyanobacteria S Bacterial PH domain - - - - - - - - - - - - bPH_5 k59_1169586_1 748247.AZKH_3081 1.15e-94 304.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,2KUXH@206389|Rhodocyclales 206389|Rhodocyclales EF Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_83301_1 436308.Nmar_0090 9.53e-73 227.0 COG1131@1|root,arCOG00194@2157|Archaea,41TB8@651137|Thaumarchaeota 651137|Thaumarchaeota E AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_83301_2 1229909.NSED_00155 3.5e-35 126.0 COG0842@1|root,arCOG01467@2157|Archaea,41SH0@651137|Thaumarchaeota 651137|Thaumarchaeota V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_545517_1 1469245.JFBG01000057_gene2376 2.42e-37 134.0 COG4665@1|root,COG4665@2|Bacteria,1RG47@1224|Proteobacteria,1S3PZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system small permease component - - - - - - - - - - - - DctQ k59_545517_2 331869.BAL199_27031 9.92e-43 152.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,4BPBH@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - - - - - - - - - - DctM k59_912287_1 396595.TK90_1984 7.18e-17 79.7 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1WWPA@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase - - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_285494_1 1049564.TevJSym_ab00030 2.53e-195 578.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,1J4PP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0591 Na proline symporter cbrA - - - - - - - - - - - HATPase_c,HisKA,PAS k59_815113_1 118173.KB235914_gene1926 4.15e-07 51.6 COG0500@1|root,COG2226@2|Bacteria,1G0WT@1117|Cyanobacteria,1HC1U@1150|Oscillatoriales 1117|Cyanobacteria Q Dimerisation domain - - - - - - - - - - - - Dimerisation2,Methyltransf_2 k59_1381311_1 69395.JQLZ01000006_gene2151 7.53e-99 298.0 COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2U3PD@28211|Alphaproteobacteria,2KG4N@204458|Caulobacterales 204458|Caulobacterales S PFAM 2-nitropropane dioxygenase NPD - - 1.3.1.9 ko:K02371 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO k59_499248_1 265072.Mfla_2364 2.23e-88 262.0 COG1795@1|root,COG1795@2|Bacteria,1NMVA@1224|Proteobacteria,2W0JG@28216|Betaproteobacteria,2KKKR@206350|Nitrosomonadales 206350|Nitrosomonadales S Formaldehyde-activating enzyme (Fae) - - - - - - - - - - - - Fae k59_1492685_1 368407.Memar_1772 1.85e-31 120.0 COG1226@1|root,arCOG01958@2157|Archaea 2157|Archaea P COG1226 Kef-type K transport systems - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_N k59_658042_1 671143.DAMO_0405 1.94e-183 524.0 COG3391@1|root,COG3391@2|Bacteria,2NQ4U@2323|unclassified Bacteria 2|Bacteria S 56kDa selenium binding protein (SBP56) - - - ko:K17285 - - - - ko00000,ko04147 - - - SBP56 k59_963341_1 215803.DB30_7799 5.76e-82 275.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2YUFE@29|Myxococcales 28221|Deltaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_1325982_1 1049564.TevJSym_bq00100 2.84e-11 69.7 COG2931@1|root,COG2982@1|root,COG3291@1|root,COG2931@2|Bacteria,COG2982@2|Bacteria,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - 3.4.21.10 ko:K01317 - - - - ko00000,ko01000,ko01002,ko04131 - - - DUF11,FG-GAP,Flg_new k59_232535_1 675817.VDA_001033 3.14e-16 80.9 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,1XTUF@135623|Vibrionales 135623|Vibrionales S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_1381320_1 1121859.KB890741_gene3766 2.19e-36 126.0 COG0316@1|root,COG0316@2|Bacteria,4NS6K@976|Bacteroidetes,47S7I@768503|Cytophagia 976|Bacteroidetes S Belongs to the HesB IscA family iscA - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_1381320_2 504472.Slin_5834 5.81e-09 55.5 COG1539@1|root,COG1539@2|Bacteria,4NQ53@976|Bacteroidetes,47QM5@768503|Cytophagia 976|Bacteroidetes H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB k59_499262_1 1089552.KI911559_gene1697 8.41e-70 235.0 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,2JQIX@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the GcvT family - - 1.5.3.1 ko:K00302 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2 k59_83326_1 519989.ECTPHS_12545 2e-95 308.0 COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1WWWU@135613|Chromatiales 135613|Chromatiales C CoA-binding domain protein - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_704735_1 1198232.CYCME_0531 4e-24 104.0 COG2433@1|root,COG2433@2|Bacteria,1R1QS@1224|Proteobacteria,1T58I@1236|Gammaproteobacteria,463VZ@72273|Thiotrichales 72273|Thiotrichales S Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124 k59_499263_1 794903.OPIT5_25145 4.92e-53 189.0 COG0821@1|root,COG0821@2|Bacteria,46SEF@74201|Verrucomicrobia,3K7GD@414999|Opitutae 414999|Opitutae I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_1645901_2 1387197.AWGA01000006_gene1426 1.94e-09 58.5 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der GO:0000027,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0022613,GO:0022618,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363 - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_1590702_1 1282876.BAOK01000002_gene381 3.05e-17 82.8 COG0475@1|root,COG0475@2|Bacteria,1MVGV@1224|Proteobacteria,2TUCH@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Sodium hydrogen exchanger - - - - - - - - - - - - Na_H_Exchanger k59_1645902_1 159087.Daro_2785 3.79e-19 89.4 COG4206@1|root,COG4206@2|Bacteria,1QTTF@1224|Proteobacteria,2WGSE@28216|Betaproteobacteria,2KZX7@206389|Rhodocyclales 206389|Rhodocyclales M TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1645902_2 262316.MAP_2772c 5.32e-88 277.0 COG2159@1|root,COG2159@2|Bacteria,2GP2D@201174|Actinobacteria,236MM@1762|Mycobacteriaceae 201174|Actinobacteria S amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_963360_1 1304885.AUEY01000045_gene250 8.13e-50 180.0 COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WJSJ@28221|Deltaproteobacteria,2MN6H@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_499275_1 444860.E3SIQ0_9CAUD 1.85e-93 280.0 4QAJD@10239|Viruses,4QW4M@35237|dsDNA viruses no RNA stage,4QQ7U@28883|Caudovirales,4QIAP@10662|Myoviridae 10662|Myoviridae S gp32 DNA binding protein like - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_337816_1 472759.Nhal_2481 1.84e-24 100.0 28JXP@1|root,2Z9N4@2|Bacteria,1MXG4@1224|Proteobacteria,1S2DJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - - - - - - - - - - Peptidase_C92 k59_1286689_1 1236959.BAMT01000002_gene1909 2.38e-91 271.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,2VHGQ@28216|Betaproteobacteria,2KMC5@206350|Nitrosomonadales 206350|Nitrosomonadales EH TIGRFAM glutamine amidotransferase of anthranilate synthase - - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_84869_1 1191523.MROS_1494 1.27e-72 234.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_444599_1 1207063.P24_03036 2.54e-52 171.0 COG0412@1|root,COG0412@2|Bacteria,1MW88@1224|Proteobacteria,2U1D8@28211|Alphaproteobacteria,2JR1X@204441|Rhodospirillales 204441|Rhodospirillales Q Dienelactone hydrolase family - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_500778_1 338966.Ppro_1736 6.47e-31 122.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,43TWZ@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1647373_1 330214.NIDE3350 2.3e-79 237.0 COG2010@1|root,COG2010@2|Bacteria,3J17C@40117|Nitrospirae 2|Bacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - CopD,Cytochrome_CBB3 k59_444601_2 143224.JQMD01000002_gene1536 1.7e-18 91.7 2BVW3@1|root,2Z7TB@2|Bacteria,4NJ8C@976|Bacteroidetes,1HZ31@117743|Flavobacteriia 976|Bacteroidetes S 5'-nucleotidase - - 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5-nucleotidase k59_1494174_1 873449.STRCR_1825 1.95e-39 147.0 COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,4HA1D@91061|Bacilli 91061|Bacilli L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_705776_1 448385.sce7305 3.98e-86 272.0 COG1213@1|root,COG2513@1|root,COG1213@2|Bacteria,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,42PWB@68525|delta/epsilon subdivisions,2X5K5@28221|Deltaproteobacteria 28221|Deltaproteobacteria C TIGRFAM phosphoenolpyruvate phosphomutase - - 5.4.2.9 ko:K01841 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 - R00661 RC02792 ko00000,ko00001,ko01000 - - - CTP_transf_like,NTP_transf_3,PEP_mutase k59_338961_1 1122603.ATVI01000005_gene2820 3.81e-14 78.6 COG1233@1|root,COG1233@2|Bacteria 2|Bacteria Q all-trans-retinol 13,14-reductase activity - - 1.3.99.23,5.2.1.13 ko:K09516,ko:K09835 ko00830,ko00906,ko01100,ko01110,map00830,map00906,map01100,map01110 M00097 R07163,R07512 RC01835,RC01960 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase,NAD_binding_8 k59_1494182_2 671143.DAMO_2755 5.32e-62 214.0 COG0568@1|root,COG0568@2|Bacteria,2NNY9@2323|unclassified Bacteria 2|Bacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoD GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_659653_1 330214.NIDE0364 1.89e-86 261.0 COG1192@1|root,COG1192@2|Bacteria,3J0H4@40117|Nitrospirae 40117|Nitrospirae D Cellulose biosynthesis protein BcsQ - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1382285_1 395493.BegalDRAFT_0212 9.15e-268 740.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,460AT@72273|Thiotrichales 72273|Thiotrichales C Belongs to the heme-copper respiratory oxidase family - - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_1382285_2 760117.JN27_04155 1.6e-111 324.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,472VR@75682|Oxalobacteraceae 28216|Betaproteobacteria C Cytochrome C oxidase, mono-heme subunit/FixO ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_659659_1 985867.AEWF01000003_gene736 4.33e-32 128.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,2TRCZ@28211|Alphaproteobacteria,47FZ3@766|Rickettsiales 766|Rickettsiales S OPT oligopeptide transporter protein - - - - - - - - - - - - OPT k59_11600_1 105559.Nwat_1985 1.29e-99 300.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,1WWVX@135613|Chromatiales 135613|Chromatiales E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1494199_1 1205680.CAKO01000002_gene2394 1.59e-24 105.0 COG2251@1|root,COG2251@2|Bacteria,1QU5K@1224|Proteobacteria,2TW0K@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - RNase_H_2 k59_131895_1 1260251.SPISAL_03990 3.93e-97 298.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1WX2I@135613|Chromatiales 135613|Chromatiales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_1122155_1 944481.JAFP01000001_gene1297 1.13e-51 185.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2M6R5@213113|Desulfurellales 28221|Deltaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_861108_2 1121024.AUCD01000023_gene726 6.45e-09 59.7 COG2189@1|root,COG2189@2|Bacteria,1UHUQ@1239|Firmicutes,4HCEV@91061|Bacilli 91061|Bacilli L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_1591945_1 1163408.UU9_13498 3.57e-21 93.2 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1X3MB@135614|Xanthomonadales 135614|Xanthomonadales J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB k59_1647427_2 1499968.TCA2_0452 4.28e-34 125.0 COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,4HII3@91061|Bacilli,26WY5@186822|Paenibacillaceae 91061|Bacilli H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS08510 CoaE k59_659692_1 880070.Cycma_4553 1.43e-47 166.0 COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,4NM18@976|Bacteroidetes,47XKA@768503|Cytophagia 976|Bacteroidetes C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4_20,Pyr_redox_2 k59_444657_1 1229909.NSED_03790 5.95e-71 229.0 COG0277@1|root,arCOG00337@2157|Archaea,41T0E@651137|Thaumarchaeota 651137|Thaumarchaeota C FAD linked - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_1382311_1 1205753.A989_03180 0.000614 42.4 COG4969@1|root,COG4969@2|Bacteria,1N7EQ@1224|Proteobacteria,1SCES@1236|Gammaproteobacteria,1X7XK@135614|Xanthomonadales 135614|Xanthomonadales NU Belongs to the N-Me-Phe pilin family - - - ko:K02650 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - N_methyl,Pilin k59_177544_1 566466.NOR53_1681 5.36e-44 161.0 28HMZ@1|root,33SQT@2|Bacteria,1NSN6@1224|Proteobacteria,1SJN2@1236|Gammaproteobacteria,1J97Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_964534_1 391595.RLO149_c015120 1.12e-61 216.0 COG2114@1|root,COG3899@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,COG3903@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,2P3FI@2433|Roseobacter 28211|Alphaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain MA20_09880 - - - - - - - - - - - AAA_16,Guanylate_cyc,SAM_1,SAM_2 k59_964538_1 238854.Q5GQW5_BPSYP 9.15e-10 67.8 4QI3D@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_233663_1 706587.Desti_1057 2.58e-26 109.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,42PMQ@68525|delta/epsilon subdivisions,2WKB8@28221|Deltaproteobacteria,2MQEZ@213462|Syntrophobacterales 28221|Deltaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_599561_1 1459636.NTE_02403 1.97e-40 139.0 COG0251@1|root,arCOG01630@2157|Archaea,41T4N@651137|Thaumarchaeota 651137|Thaumarchaeota J YjgF/chorismate_mutase-like, putative endoribonuclease - - - - - - - - - - - - YjgF_endoribonc k59_599561_2 436308.Nmar_0677 8.78e-15 78.2 arCOG04668@1|root,arCOG04668@2157|Archaea,41SMD@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_177551_1 1379858.N508_01986 2.02e-29 114.0 COG0652@1|root,COG0652@2|Bacteria,2GG0J@200930|Deferribacteres 200930|Deferribacteres O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - Pro_isomerase k59_177551_2 886293.Sinac_3436 2.25e-18 83.2 COG3228@1|root,COG3228@2|Bacteria,2IZES@203682|Planctomycetes 203682|Planctomycetes S Belongs to the MtfA family - - - ko:K09933 - - - - ko00000,ko01002 - - - Peptidase_M90,SEC-C k59_339013_1 1122137.AQXF01000001_gene3288 7.66e-35 133.0 COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,2TS5S@28211|Alphaproteobacteria 28211|Alphaproteobacteria M membrane-bound lytic murein transglycosylase mltA - - ko:K08304 - - - - ko00000,ko01000,ko01011 - GH102 - 3D,MltA k59_1647453_1 1123367.C666_15420 4.99e-33 119.0 COG0824@1|root,COG0824@2|Bacteria,1RF7Q@1224|Proteobacteria,2VR5T@28216|Betaproteobacteria,2KWHU@206389|Rhodocyclales 206389|Rhodocyclales S Thioesterase-like superfamily - - 3.1.2.23 ko:K01075 ko00130,ko00362,ko01100,ko01110,ko01120,map00130,map00362,map01100,map01110,map01120 - R01301 RC00004,RC00174 ko00000,ko00001,ko01000 - - - 4HBT_2 k59_11616_2 298654.FraEuI1c_3224 2.17e-05 51.2 COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria 201174|Actinobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase k59_392454_2 330214.NIDE1286 1.01e-19 87.8 COG1413@1|root,COG1413@2|Bacteria,3J1E2@40117|Nitrospirae 40117|Nitrospirae C Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - HEAT_2,HEAT_PBS k59_11617_1 861299.J421_2423 1.9e-101 319.0 COG0495@1|root,COG0495@2|Bacteria,1ZSXC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Leucyl-tRNA synthetase, Domain 2 leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_816761_1 518766.Rmar_0118 1.02e-71 230.0 COG2939@1|root,COG2939@2|Bacteria,4NF48@976|Bacteroidetes,1FJ5Z@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Serine carboxypeptidase - - - - - - - - - - - - Peptidase_S10 k59_913589_2 1122611.KB903953_gene5729 5e-47 161.0 COG0436@1|root,COG0436@2|Bacteria,2GTYR@201174|Actinobacteria 201174|Actinobacteria E Aminotransferase - - 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - - - k59_869007_1 379066.GAU_1917 1.14e-67 215.0 COG0468@1|root,COG0468@2|Bacteria,1ZT78@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_1298439_1 237368.SCABRO_01711 1.99e-18 85.9 COG1533@1|root,COG1533@2|Bacteria,2J47J@203682|Planctomycetes 203682|Planctomycetes L DNA photolyase activity - - 4.1.99.14 ko:K03716 - - - - ko00000,ko01000 - - - - k59_1506050_1 439292.Bsel_1864 1.56e-62 205.0 COG1060@1|root,COG1060@2|Bacteria,1TRHG@1239|Firmicutes 1239|Firmicutes H Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnC - 1.21.98.1,2.5.1.77 ko:K11779,ko:K11784 ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120 M00378 R08588,R09396 RC01381,RC02329,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_95873_1 756499.Desde_0320 2.81e-54 182.0 COG0388@1|root,COG0388@2|Bacteria,1TQDK@1239|Firmicutes,24AWV@186801|Clostridia,260HN@186807|Peptococcaceae 186801|Clostridia S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - - - - - - - - - - CN_hydrolase k59_830164_1 926566.Terro_2899 4.55e-75 242.0 COG2303@1|root,COG2303@2|Bacteria,3Y6FS@57723|Acidobacteria,2JM7Q@204432|Acidobacteriia 204432|Acidobacteriia E GMC oxidoreductase - - - - - - - - - - - - - k59_870089_1 378806.STAUR_5849 2.93e-20 84.7 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,42VJQ@68525|delta/epsilon subdivisions,2WR7Z@28221|Deltaproteobacteria,2YVPB@29|Myxococcales 28221|Deltaproteobacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_870089_2 479434.Sthe_1595 7.08e-29 110.0 COG0359@1|root,COG0359@2|Bacteria,2G6V2@200795|Chloroflexi,27YFC@189775|Thermomicrobia 189775|Thermomicrobia J Ribosomal protein L9, C-terminal domain rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_456103_1 269799.Gmet_2013 1.6e-10 66.2 COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,42VRI@68525|delta/epsilon subdivisions,2WRUV@28221|Deltaproteobacteria,43VFC@69541|Desulfuromonadales 28221|Deltaproteobacteria G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_556368_1 562970.Btus_0228 6.73e-12 66.6 COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,4HANB@91061|Bacilli,2781V@186823|Alicyclobacillaceae 91061|Bacilli O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_556368_2 490899.DKAM_1405 7.17e-08 56.6 COG0030@1|root,arCOG04131@2157|Archaea,2XQCE@28889|Crenarchaeota 28889|Crenarchaeota J Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_1026423_1 933262.AXAM01000008_gene1963 1.61e-29 122.0 COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1MV93@1224|Proteobacteria,42MQH@68525|delta/epsilon subdivisions,2WJPV@28221|Deltaproteobacteria,2MJ8R@213118|Desulfobacterales 28221|Deltaproteobacteria CE Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - iAF987.Gmet_3512 Aldedh,Pro_dh k59_1081988_1 436308.Nmar_0713 5.95e-79 237.0 arCOG10536@1|root,arCOG10536@2157|Archaea 2157|Archaea S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 k59_1133985_1 1177154.Y5S_00555 4.26e-110 342.0 COG1129@1|root,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,1T1GD@1236|Gammaproteobacteria 1236|Gammaproteobacteria V (ABC) transporter ybhF - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_925417_1 323848.Nmul_A0650 3.05e-74 229.0 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2VJQQ@28216|Betaproteobacteria,3724M@32003|Nitrosomonadales 28216|Betaproteobacteria F Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage mtaP - 2.4.2.28 ko:K00772,ko:K03815 ko00230,ko00270,ko01100,ko01110,map00230,map00270,map01100,map01110 M00034 R01402,R02297 RC00063,RC00122,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_1391076_2 85643.Tmz1t_2959 1e-07 55.1 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VMWP@28216|Betaproteobacteria,2KVYZ@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.5.1,3.1.2.25 ko:K18361 ko00360,map00360 - R07222,R07294 RC00004,RC01844,RC01903 ko00000,ko00001,ko01000 - - - Molybdopterin,Molydop_binding k59_1660918_1 195250.CM001776_gene3954 2.37e-07 57.0 COG0795@1|root,COG0795@2|Bacteria,1G14H@1117|Cyanobacteria,1H045@1129|Synechococcus 1117|Cyanobacteria S Predicted permease YjgP/YjgQ family - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1449639_1 1380370.JIBA01000015_gene376 4.91e-54 192.0 COG0642@1|root,COG2205@2|Bacteria,2I2M2@201174|Actinobacteria,4FFYD@85021|Intrasporangiaceae 201174|Actinobacteria T GAF domain - - - - - - - - - - - - DUF3365,GAF_2,HAMP,HATPase_c,HisKA,Response_reg k59_514211_1 1227457.C451_04918 7.51e-07 56.6 COG0642@1|root,arCOG02327@2157|Archaea,2XTH8@28890|Euryarchaeota,23S6Q@183963|Halobacteria 183963|Halobacteria T Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_7TM,PAS_8 k59_1507638_1 105559.Nwat_0716 1.24e-74 233.0 COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,1RPYF@1236|Gammaproteobacteria,1WX5H@135613|Chromatiales 135613|Chromatiales P pfam abc-3 - - - ko:K09816 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_456132_1 1123400.KB904749_gene720 3.86e-11 67.4 COG1100@1|root,COG1100@2|Bacteria,1QXSV@1224|Proteobacteria,1S5FA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 50S ribosome-binding GTPase - - - ko:K06883 - - - - ko00000 - - - DUF697,MMR_HSR1 k59_1660927_1 713586.KB900536_gene2165 1.55e-39 142.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1WVWF@135613|Chromatiales 135613|Chromatiales H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_1179437_1 3649.evm.model.supercontig_46.160 8.35e-18 85.1 COG0204@1|root,KOG2848@2759|Eukaryota,37M0C@33090|Viridiplantae,3GDYJ@35493|Streptophyta,3HN2C@3699|Brassicales 35493|Streptophyta I 1-acyl-sn-glycerol-3-phosphate acyltransferase - GO:0000003,GO:0003006,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0007275,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009507,GO:0009526,GO:0009536,GO:0009790,GO:0009791,GO:0009793,GO:0009941,GO:0009987,GO:0010154,GO:0019637,GO:0022414,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0061458,GO:0071704,GO:0090407,GO:1901576 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_514225_1 909663.KI867150_gene1145 2.77e-97 312.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WISW@28221|Deltaproteobacteria,2MQA5@213462|Syntrophobacterales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1242276_1 292459.STH1614 5.43e-06 54.3 COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia 186801|Clostridia E PFAM Extracellular ligand-binding receptor braC - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1391088_1 472759.Nhal_1712 4.26e-138 407.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WXNN@135613|Chromatiales 1236|Gammaproteobacteria F PFAM glycosyl transferase family 35 - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_673098_1 1229909.NSED_00695 5.83e-79 248.0 COG1571@1|root,arCOG01115@2157|Archaea,41S9G@651137|Thaumarchaeota 651137|Thaumarchaeota J ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA tiaS - 6.3.4.22 ko:K06932 - - - - ko00000,ko01000,ko03016 - - - DUF1743 k59_186015_1 1122180.Lokhon_03102 5.88e-16 75.5 2BC0N@1|root,30KFT@2|Bacteria,1Q6GJ@1224|Proteobacteria,2VCMC@28211|Alphaproteobacteria,2P9WW@245186|Loktanella 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_870145_1 743721.Psesu_0389 7.25e-16 80.5 2DA4I@1|root,32TUN@2|Bacteria,1N0WK@1224|Proteobacteria,1S6HI@1236|Gammaproteobacteria,1X665@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_974079_1 331678.Cphamn1_0868 3.42e-09 54.7 COG1917@1|root,COG1917@2|Bacteria,1FE3K@1090|Chlorobi 1090|Chlorobi S PFAM Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 k59_974079_2 458817.Shal_0815 1.16e-17 79.0 COG1917@1|root,COG1917@2|Bacteria,1MZNT@1224|Proteobacteria,1S8TU@1236|Gammaproteobacteria,2QCN3@267890|Shewanellaceae 1236|Gammaproteobacteria S PFAM Cupin 2, conserved barrel domain protein - - - ko:K11312 - - - - ko00000 - - - Cupin_2 k59_1179458_1 1411685.U062_01600 1.06e-08 57.0 COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,1S612@1236|Gammaproteobacteria,1J6KP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family ygfA GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298 5-FTHF_cyc-lig k59_514256_1 1265313.HRUBRA_02254 6.72e-51 174.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,1J4M8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_925462_1 686340.Metal_3444 4.74e-08 59.3 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1XEVV@135618|Methylococcales 135618|Methylococcales EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1134030_1 59748.PA0554 2.17e-13 72.4 COG0484@1|root,COG0484@2|Bacteria,3WSX8@544448|Tenericutes 544448|Tenericutes O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686,ko:K05516 - - - - ko00000,ko03029,ko03036,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1660976_1 322710.Avin_04360 5.26e-72 228.0 COG1453@1|root,COG1453@2|Bacteria,1NIR6@1224|Proteobacteria,1T3EJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_22 k59_974088_2 981384.AEYW01000001_gene1564 2.24e-49 169.0 COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,1PYP4@1224|Proteobacteria,2TVEP@28211|Alphaproteobacteria,4NCYJ@97050|Ruegeria 28211|Alphaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,Response_reg k59_514267_1 76114.ebA6680 3.4e-54 177.0 COG0500@1|root,COG2226@2|Bacteria,1MVIS@1224|Proteobacteria,2VRUU@28216|Betaproteobacteria,2KWI9@206389|Rhodocyclales 206389|Rhodocyclales Q ubiE/COQ5 methyltransferase family - - 2.1.1.17,2.1.1.71 ko:K00570 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00091 R01320,R02056,R03424 RC00003,RC00060,RC00181,RC00496 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_1449676_1 1079460.ATTQ01000005_gene2146 1.84e-23 104.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,TPR_16,TPR_2,TPR_8 k59_1026485_1 1047013.AQSP01000138_gene1051 1.26e-30 121.0 COG0438@1|root,COG0438@2|Bacteria,2NPA0@2323|unclassified Bacteria 2|Bacteria M glycosyl transferase group 1 - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_765046_2 1449355.JQNR01000005_gene5367 1.36e-39 140.0 COG1082@1|root,COG1082@2|Bacteria,2IH92@201174|Actinobacteria 201174|Actinobacteria G Xylose isomerase domain protein TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_673145_1 187272.Mlg_1812 3.75e-56 185.0 COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,1WX0F@135613|Chromatiales 135613|Chromatiales S Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxH - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos,Metallophos_2 k59_830285_1 1192034.CAP_4075 3.02e-18 83.6 COG1116@1|root,COG1116@2|Bacteria,1P4HB@1224|Proteobacteria,42NNH@68525|delta/epsilon subdivisions,2WUV9@28221|Deltaproteobacteria,2YUPS@29|Myxococcales 28221|Deltaproteobacteria P ABC transporter - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_608100_1 1201288.M900_1378 4.42e-41 148.0 COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,42QEX@68525|delta/epsilon subdivisions,2MSY0@213481|Bdellovibrionales,2WMFU@28221|Deltaproteobacteria 213481|Bdellovibrionales F A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response srkA - - - - - - - - - - - APH k59_186037_1 1123360.thalar_01845 7.45e-09 57.4 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2TSD1@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_186037_2 760568.Desku_2556 2.68e-44 152.0 COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,260D7@186807|Peptococcaceae 186801|Clostridia H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_514283_1 1279017.AQYJ01000021_gene2888 3.72e-101 305.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,465TC@72275|Alteromonadaceae 1236|Gammaproteobacteria CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1990928 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - iECs_1301.ECs0077,iYL1228.KPN_00079,iZ_1308.Z0082 Iso_dh k59_1179476_1 1229909.NSED_00815 7.79e-50 159.0 arCOG10520@1|root,arCOG10520@2157|Archaea,41T7W@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1179476_2 1229909.NSED_00810 1.58e-63 194.0 COG0640@1|root,arCOG00731@2157|Archaea,41T40@651137|Thaumarchaeota 651137|Thaumarchaeota K Bacterial regulatory protein, arsR family - - - - - - - - - - - - HTH_5 k59_1179476_3 436308.Nmar_0201 1.76e-09 57.0 COG1032@1|root,arCOG01363@2157|Archaea,41S6P@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - - - - - - - - - - - Radical_SAM k59_143086_1 1121935.AQXX01000144_gene4308 2.32e-62 214.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C,Acyltransferase,Aminotran_1_2,NAD_binding_4,PP-binding,Thioesterase k59_925490_1 1110702.G8GIV1_9CAUD 2.2e-15 76.3 4QC5J@10239|Viruses,4QXP7@35237|dsDNA viruses no RNA stage,4QTBX@28883|Caudovirales,4QJQT@10662|Myoviridae 10662|Myoviridae S Domain of unknown function (DUF2828) - - - - - - - - - - - - - k59_830299_1 1244869.H261_06576 1.17e-75 241.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,2JRZP@204441|Rhodospirillales 204441|Rhodospirillales C B12 binding domain - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_1600539_2 1317118.ATO8_00265 6.39e-26 100.0 COG1416@1|root,COG1416@2|Bacteria,1RE8C@1224|Proteobacteria,2U80W@28211|Alphaproteobacteria 28211|Alphaproteobacteria S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE k59_556462_1 870187.Thini_0824 1.9e-40 140.0 COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,1S5X6@1236|Gammaproteobacteria,460RV@72273|Thiotrichales 72273|Thiotrichales T Low molecular weight phosphotyrosine protein phosphatase yfkJ - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc k59_143094_1 1122939.ATUD01000001_gene761 2.7e-21 99.4 COG1012@1|root,COG1012@2|Bacteria,2GM5R@201174|Actinobacteria,4CPBR@84995|Rubrobacteria 84995|Rubrobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.88,1.5.5.2 ko:K00294,ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh k59_401130_1 1094980.Mpsy_0698 1.53e-84 268.0 COG0058@1|root,arCOG01421@2157|Archaea,2XV8J@28890|Euryarchaeota,2NACZ@224756|Methanomicrobia 224756|Methanomicrobia G PFAM glycosyl transferase, family 35 - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_1600543_1 283942.IL2637 3.07e-13 75.1 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,2QFUJ@267893|Idiomarinaceae 1236|Gammaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_243528_1 335543.Sfum_0266 1.75e-75 234.0 COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,42PQM@68525|delta/epsilon subdivisions,2WJIF@28221|Deltaproteobacteria,2MRCK@213462|Syntrophobacterales 28221|Deltaproteobacteria Q ubiE/COQ5 methyltransferase family - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - HTH_20,Methyltransf_31 k59_1134064_1 1283300.ATXB01000001_gene1637 3.5e-15 73.2 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1XE78@135618|Methylococcales 135618|Methylococcales O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_1134064_2 360910.BAV1236 2.8e-121 363.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2VH0Z@28216|Betaproteobacteria,3T2JI@506|Alcaligenaceae 28216|Betaproteobacteria S Peptidogalycan biosysnthesis/recognition - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_765073_2 366602.Caul_5303 3.82e-144 416.0 COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2TSWA@28211|Alphaproteobacteria,2KF1F@204458|Caulobacterales 204458|Caulobacterales E Converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH tdh - 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1026523_1 1123393.KB891327_gene473 1.49e-93 278.0 COG2210@1|root,COG2210@2|Bacteria,1QCK1@1224|Proteobacteria,2WE8S@28216|Betaproteobacteria,1KSAI@119069|Hydrogenophilales 119069|Hydrogenophilales S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 k59_1391143_1 330214.NIDE1156 3.45e-35 126.0 COG0484@1|root,COG0484@2|Bacteria 2|Bacteria O heat shock protein binding dnaJ2 - - ko:K03686,ko:K05516 - - - - ko00000,ko03029,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_1391143_2 1120972.AUMH01000005_gene847 2.74e-06 49.3 COG1228@1|root,COG1228@2|Bacteria,1TQQ0@1239|Firmicutes,4HDKW@91061|Bacilli 91061|Bacilli Q Imidazolonepropionase and related amidohydrolases hutI - - - - - - - - - - - Amidohydro_1 k59_1600551_1 236097.ADG881_2129 2.32e-65 215.0 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1XQZT@135619|Oceanospirillales 135619|Oceanospirillales PT COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - Rhodanese,cNMP_binding k59_1507777_1 481448.Minf_0020 2.46e-93 296.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,46SVA@74201|Verrucomicrobia,37FY0@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_673203_1 1121918.ARWE01000001_gene231 5.66e-33 129.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43S4M@69541|Desulfuromonadales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1608611_1 1085623.GNIT_3466 4.24e-17 82.8 COG3031@1|root,COG3031@2|Bacteria,1RD3I@1224|Proteobacteria,1RQKA@1236|Gammaproteobacteria,465CV@72275|Alteromonadaceae 1236|Gammaproteobacteria U General secretion pathway protein C gspC GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K02452 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - PDZ_2,T2SSC k59_1253010_1 240015.ACP_0337 1.96e-36 137.0 COG3046@1|root,COG3046@2|Bacteria,3Y47V@57723|Acidobacteria,2JJ03@204432|Acidobacteriia 204432|Acidobacteriia S Deoxyribodipyrimidine photo-lyase-related protein - - - ko:K06876 - - - - ko00000 - - - DPRP,FAD_binding_7 k59_1093416_1 1254432.SCE1572_34410 2.16e-124 369.0 COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,42N4Y@68525|delta/epsilon subdivisions,2WKGT@28221|Deltaproteobacteria,2YXYB@29|Myxococcales 28221|Deltaproteobacteria S DinB superfamily - - 1.14.99.50 ko:K18912 ko00340,map00340 - R11013 RC03323,RC03324 ko00000,ko00001,ko01000 - - - DinB_2,FGE-sulfatase,Methyltransf_31 k59_412920_1 257310.BB3964 6.11e-30 119.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2W09W@28216|Betaproteobacteria,3T6CP@506|Alcaligenaceae 28216|Betaproteobacteria E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1460020_1 1123229.AUBC01000031_gene285 3.32e-28 111.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2TSWH@28211|Alphaproteobacteria,3JRXN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria D Cellulose biosynthesis protein BcsQ parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1460020_2 1392486.JIAF01000004_gene962 6.87e-09 58.5 COG1475@1|root,COG1475@2|Bacteria,4NFZ9@976|Bacteroidetes,2FP81@200643|Bacteroidia 976|Bacteroidetes K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_1253028_1 1249627.D779_1681 4.63e-42 157.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMFB@1236|Gammaproteobacteria,1X2JU@135613|Chromatiales 135613|Chromatiales E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 k59_566977_1 472759.Nhal_1221 1.28e-48 163.0 COG5424@1|root,COG5424@2|Bacteria,1NQWN@1224|Proteobacteria,1SMYT@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ - - - - - - - - - - - - - k59_566977_2 105559.Nwat_1520 1.78e-31 114.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,1S400@1236|Gammaproteobacteria,1WYBM@135613|Chromatiales 135613|Chromatiales S PFAM Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_309846_1 1415754.JQMK01000002_gene2697 1.46e-121 385.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,466FE@72275|Alteromonadaceae 1236|Gammaproteobacteria NU Neisseria PilC beta-propeller domain pilY - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,PA14 k59_1552471_2 290397.Adeh_0640 7.44e-16 72.0 COG1396@1|root,COG1396@2|Bacteria,1QYFR@1224|Proteobacteria,43CBW@68525|delta/epsilon subdivisions,2X7MR@28221|Deltaproteobacteria,2Z2CU@29|Myxococcales 28221|Deltaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_31 k59_775184_1 443218.AS9A_0277 1.03e-27 110.0 COG0560@1|root,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,233DS@1762|Mycobacteriaceae 201174|Actinobacteria E HAD-superfamily subfamily IB hydrolase, TIGR01490 serB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - HAD k59_1552482_1 765911.Thivi_3845 2.19e-58 192.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,1RPRD@1236|Gammaproteobacteria,1X29Z@135613|Chromatiales 135613|Chromatiales C PFAM Alcohol dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N_2 k59_936996_1 30611.ENSOGAP00000003991 2.22e-05 47.0 COG0604@1|root,KOG1198@2759|Eukaryota,38GB8@33154|Opisthokonta,3BBM9@33208|Metazoa,3CXRG@33213|Bilateria,47Z7C@7711|Chordata,492P1@7742|Vertebrata,3JAMP@40674|Mammalia,35H02@314146|Euarchontoglires,4MG9U@9443|Primates 33208|Metazoa C Tumor protein p53 inducible protein 3 TP53I3 GO:0000166,GO:0003674,GO:0003824,GO:0003960,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009987,GO:0010941,GO:0016491,GO:0016651,GO:0016655,GO:0019362,GO:0019637,GO:0034641,GO:0036094,GO:0042802,GO:0042803,GO:0042981,GO:0043067,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0048038,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0051186,GO:0055086,GO:0055114,GO:0065007,GO:0070402,GO:0071704,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564 - ko:K10133 ko04115,map04115 - - - ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_936996_2 1121952.ATXT01000015_gene168 5.03e-19 89.4 COG0038@1|root,COG0038@2|Bacteria,2GPPN@201174|Actinobacteria,4FNNY@85023|Microbacteriaceae 201174|Actinobacteria P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC k59_880607_1 1238182.C882_0490 6.89e-102 323.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,2JQJ8@204441|Rhodospirillales 204441|Rhodospirillales S transport system, fused permease components - - - - - - - - - - - - DUF3394,DctM k59_880608_1 351348.Maqu_3130 5.02e-39 140.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,1RSKA@1236|Gammaproteobacteria 1236|Gammaproteobacteria C radical SAM protein nirJ - - ko:K06139 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_880608_2 1255043.TVNIR_1647 1.45e-31 115.0 COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,1S7GD@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Nitrite reductase heme biosynthesis H protein nirH - - - - - - - - - - - HTH_AsnC-type k59_1189870_1 379066.GAU_3508 5.85e-114 343.0 COG4584@1|root,COG4584@2|Bacteria,1ZV8R@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Integrase core domain - - - - - - - - - - - - rve k59_1037021_1 997296.PB1_02435 4.34e-06 53.9 COG4106@1|root,COG4106@2|Bacteria,1V21K@1239|Firmicutes,4HE11@91061|Bacilli,1ZBE4@1386|Bacillus 91061|Bacilli H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_1146728_1 105559.Nwat_1612 6.3e-124 382.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1WXAA@135613|Chromatiales 135613|Chromatiales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_1253085_1 1178482.BJB45_14975 3.77e-17 81.6 COG4067@1|root,COG4067@2|Bacteria,1RFKA@1224|Proteobacteria,1S40X@1236|Gammaproteobacteria,1XP6P@135619|Oceanospirillales 135619|Oceanospirillales O protein conserved in archaea - - - - - - - - - - - - Zn_protease k59_413001_1 1469245.JFBG01000086_gene1624 7.89e-67 207.0 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1WWTG@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, E subunit - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_413001_2 1123502.AQXD01000004_gene28 2.66e-17 81.3 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1X2ZD@135614|Xanthomonadales 135614|Xanthomonadales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_1037046_1 1219035.NT2_09_00200 4.51e-57 186.0 COG1063@1|root,COG1063@2|Bacteria,1MWX0@1224|Proteobacteria,2TU6B@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Dehydrogenase - - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N k59_1037046_2 1123023.JIAI01000008_gene1611 8.31e-09 60.8 COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,4E0C4@85010|Pseudonocardiales 201174|Actinobacteria Q Cytochrome P450 - - - - - - - - - - - - p450 k59_1093499_1 870187.Thini_0583 2.65e-69 221.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,1RNMF@1236|Gammaproteobacteria,460BX@72273|Thiotrichales 72273|Thiotrichales S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_361737_1 1117958.PE143B_0106235 1.28e-102 305.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_1460114_1 330214.NIDE4133 7.61e-152 452.0 COG0532@1|root,COG0532@2|Bacteria,3J0CC@40117|Nitrospirae 40117|Nitrospirae J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_153882_1 1528106.JRJE01000032_gene3124 1.23e-111 330.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,2JPCY@204441|Rhodospirillales 204441|Rhodospirillales I COG1960 Acyl-CoA dehydrogenases - - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_361755_1 511062.GU3_14385 2.9e-42 154.0 COG0591@1|root,COG0591@2|Bacteria,1MWX6@1224|Proteobacteria,1RSQD@1236|Gammaproteobacteria,1Y5XI@135624|Aeromonadales 135624|Aeromonadales E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1401564_2 1137799.GZ78_00330 3.78e-43 153.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RTA0@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - - - - - - - - - - Oxidored_FMN k59_309961_1 330214.NIDE3363 9.83e-85 258.0 COG0811@1|root,COG0811@2|Bacteria,3J0PX@40117|Nitrospirae 40117|Nitrospirae U MotA/TolQ/ExbB proton channel family - - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_1093547_1 330214.NIDE0498 8.55e-86 268.0 COG1322@1|root,COG1322@2|Bacteria,3J15T@40117|Nitrospirae 40117|Nitrospirae S RmuC family - - - ko:K09760 - - - - ko00000 - - - RmuC k59_1253143_1 1121403.AUCV01000007_gene1279 7.36e-60 201.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MPSH@213118|Desulfobacterales 28221|Deltaproteobacteria T Sigma-54 interaction domain - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1552591_1 1001585.MDS_4955 2.05e-58 199.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1YCU3@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_1401583_1 1049564.TevJSym_ap00260 7.83e-67 223.0 COG0637@1|root,COG1234@1|root,COG0637@2|Bacteria,COG1234@2|Bacteria,1PPRD@1224|Proteobacteria,1RRV8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Beta-lactamase superfamily domain rnz - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - CLP1_P,Lactamase_B,Lactamase_B_2 k59_937114_2 948071.S4S2F1_9CAUD 2.55e-09 57.8 4QGR5@10239|Viruses,4QWIC@35237|dsDNA viruses no RNA stage,4QTRA@28883|Caudovirales,4QNYN@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_775285_1 1235457.C404_19575 8.87e-32 121.0 COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2VI5G@28216|Betaproteobacteria,1K3TY@119060|Burkholderiaceae 28216|Betaproteobacteria I enoyl-CoA hydratase - - 4.2.1.18 ko:K13766,ko:K15312 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000,ko01008 - - - ECH_1 k59_21553_1 272624.lpg0323 5.73e-133 416.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1JD5C@118969|Legionellales 118969|Legionellales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1608753_1 12957.ACEP15258-PA 5.49e-17 85.5 COG0039@1|root,KOG1495@2759|Eukaryota,38G9C@33154|Opisthokonta,3BGT7@33208|Metazoa,3CW73@33213|Bilateria,41XUM@6656|Arthropoda,3SI56@50557|Insecta,46GC2@7399|Hymenoptera 33208|Metazoa C lactate/malate dehydrogenase, NAD binding domain - - 1.1.1.27 ko:K00016 ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922 - R00703,R01000,R03104 RC00031,RC00044 ko00000,ko00001,ko01000,ko04147 - - - Ldh_1_C,Ldh_1_N k59_880715_1 265072.Mfla_2268 1.08e-85 266.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2VIKZ@28216|Betaproteobacteria,2KMBW@206350|Nitrosomonadales 206350|Nitrosomonadales M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_620188_1 637911.AM305_11950 1.25e-75 241.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1Y7FG@135625|Pasteurellales 135625|Pasteurellales H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB k59_620188_2 1123253.AUBD01000011_gene2067 1e-22 97.8 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1X4GI@135614|Xanthomonadales 135614|Xanthomonadales M transferase waaA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N k59_983837_1 1254432.SCE1572_36155 4.91e-37 129.0 COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,4360E@68525|delta/epsilon subdivisions,2X0HX@28221|Deltaproteobacteria,2Z0TS@29|Myxococcales 28221|Deltaproteobacteria L High confidence in function and specificity - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_1608757_1 1163407.UU7_03552 1.43e-175 504.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1X3UC@135614|Xanthomonadales 135614|Xanthomonadales J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_413099_1 857087.Metme_0253 2.41e-10 61.2 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1XESR@135618|Methylococcales 135618|Methylococcales D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_413099_2 323261.Noc_2854 6.61e-29 112.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1WW5R@135613|Chromatiales 135613|Chromatiales M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_1401602_1 153948.NAL212_0901 2.53e-73 227.0 COG1309@1|root,COG1309@2|Bacteria,1RFC9@1224|Proteobacteria,2VTB8@28216|Betaproteobacteria,3733F@32003|Nitrosomonadales 28216|Betaproteobacteria K COQ9 - - - - - - - - - - - - COQ9,TetR_N k59_361798_1 404589.Anae109_0556 7.66e-70 232.0 COG4783@1|root,COG4783@2|Bacteria,1RAJB@1224|Proteobacteria 1224|Proteobacteria S peptidase m48, ste24p - - - - - - - - - - - - Peptidase_M48 k59_567113_1 436308.Nmar_1431 2.85e-98 292.0 COG0084@1|root,arCOG00891@2157|Archaea,41SGP@651137|Thaumarchaeota 651137|Thaumarchaeota L TatD related DNase - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_1148043_2 1441629.PCH70_25960 8.69e-17 80.5 COG2175@1|root,COG2175@2|Bacteria,1MWQ6@1224|Proteobacteria,1RP8I@1236|Gammaproteobacteria,1Z5SU@136849|Pseudomonas syringae group 1236|Gammaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_1347335_1 523791.Kkor_1830 2.35e-58 194.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1XHGT@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_1347335_2 903503.MEPCIT_295 1.89e-63 199.0 COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,1S60Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA GO:0002097,GO:0002100,GO:0003674,GO:0003824,GO:0004000,GO:0005488,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008251,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0052717,GO:0071704,GO:0090304,GO:1901360 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam,dCMP_cyt_deam_1 k59_1347335_3 595494.Tola_2732 6.01e-28 106.0 COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,1S5WH@1236|Gammaproteobacteria,1Y4NY@135624|Aeromonadales 135624|Aeromonadales S Belongs to the CinA family - - 3.5.1.42 ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA k59_255069_1 566466.NOR53_3686 8.12e-79 248.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,1RQ3D@1236|Gammaproteobacteria,1JA8Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG1541 Coenzyme F390 synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C_2 k59_199284_1 768671.ThimaDRAFT_1994 1.6e-39 144.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales 135613|Chromatiales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_199284_2 1265502.KB905932_gene1921 7.96e-08 53.1 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2VIH1@28216|Betaproteobacteria,4ACJH@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM TrkA-N domain protein trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_311059_2 870187.Thini_3075 4.39e-46 156.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,4626R@72273|Thiotrichales 72273|Thiotrichales V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1347344_1 314230.DSM3645_15790 1e-20 93.6 COG1082@1|root,COG1082@2|Bacteria,2IYD1@203682|Planctomycetes 203682|Planctomycetes G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_154872_1 1132855.KB913035_gene1758 2.47e-11 60.5 COG3439@1|root,COG3439@2|Bacteria,1RHJQ@1224|Proteobacteria,2W3X3@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_1402686_1 1125863.JAFN01000001_gene3240 6.43e-37 137.0 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42M3T@68525|delta/epsilon subdivisions,2WIV8@28221|Deltaproteobacteria 28221|Deltaproteobacteria C electron transfer flavoprotein, alpha subunit etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_1609625_1 1049564.TevJSym_ac00650 1.76e-100 311.0 COG0589@1|root,COG0589@2|Bacteria 2|Bacteria T AMP binding - - - - - - - - - - - - Usp k59_1148091_1 1504823.CCMM01000008_gene876 2.38e-23 92.4 COG0335@1|root,COG0335@2|Bacteria,2NPKD@2323|unclassified Bacteria 2|Bacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_1148091_2 1123325.JHUV01000009_gene469 9.02e-31 115.0 COG4752@1|root,COG4752@2|Bacteria,2G42R@200783|Aquificae 200783|Aquificae S SAM-dependent RNA methyltransferase - GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 - - - - - - - - - - Methyltrn_RNA_4 k59_568057_1 1142394.PSMK_p00280 4.56e-42 154.0 COG1538@1|root,COG1538@2|Bacteria,2IZPU@203682|Planctomycetes 203682|Planctomycetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1191178_1 436308.Nmar_0552 7.13e-80 247.0 COG1465@1|root,arCOG04353@2157|Archaea,41S88@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis aroB' - 1.4.1.24 ko:K11646 ko00400,ko01110,ko01130,map00400,map01110,map01130 - R08569 RC02302 ko00000,ko00001,ko01000 - - - DHQS k59_209850_2 1133849.O3I_011275 5.88e-41 148.0 COG0053@1|root,COG0053@2|Bacteria,2GQJJ@201174|Actinobacteria,4FVUX@85025|Nocardiaceae 201174|Actinobacteria P Cation efflux family - - - - - - - - - - - - Cation_efflux k59_105333_2 1123366.TH3_13364 5.37e-25 101.0 COG4520@1|root,COG4520@2|Bacteria,1N0YF@1224|Proteobacteria,2UA8D@28211|Alphaproteobacteria,2JSUH@204441|Rhodospirillales 204441|Rhodospirillales M 17 kDa outer membrane surface antigen - - - - - - - - - - - - 17kDa_Anti_2,Rick_17kDa_Anti k59_105333_4 1044.EH31_12860 1.69e-15 77.8 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2U787@28211|Alphaproteobacteria,2K074@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_Omp,OmpA k59_523269_1 1227349.C170_17622 3.26e-39 146.0 COG2272@1|root,COG2272@2|Bacteria,1UXY5@1239|Firmicutes,4HCKV@91061|Bacilli,26S80@186822|Paenibacillaceae 91061|Bacilli I Belongs to the type-B carboxylesterase lipase family pnbA - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_1202610_1 1283283.ATXA01000014_gene3543 9.11e-47 165.0 COG0183@1|root,COG0183@2|Bacteria,2GKH4@201174|Actinobacteria,4EUHT@85013|Frankiales 201174|Actinobacteria I Acetyl-CoA acetyltransferase - - - - - - - - - - - - DUF35_N,OB_aCoA_assoc k59_993334_1 1082933.MEA186_29842 3.07e-56 184.0 COG5285@1|root,COG5285@2|Bacteria,1R7DG@1224|Proteobacteria,2TTB2@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - - - - - - - - - - PhyH k59_262182_1 395965.Msil_1718 2.98e-48 174.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2TR6F@28211|Alphaproteobacteria,3NC0Z@45404|Beijerinckiaceae 28211|Alphaproteobacteria C Phosphoenolpyruvate carboxylase ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_209860_1 553178.CAPGI0001_1455 3.08e-09 58.5 COG0714@1|root,COG0714@2|Bacteria,4NDVZ@976|Bacteroidetes,1HXA1@117743|Flavobacteriia,1ERDA@1016|Capnocytophaga 976|Bacteroidetes S MCM2/3/5 family - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1620265_1 134676.ACPL_7039 1.65e-12 74.3 COG0546@1|root,COG0546@2|Bacteria,2IHMV@201174|Actinobacteria,4DCVA@85008|Micromonosporales 201174|Actinobacteria S HAD-hyrolase-like - - - - - - - - - - - - HAD_2 k59_53467_1 349521.HCH_02130 3.46e-47 159.0 COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,1RQAB@1236|Gammaproteobacteria,1XJ5X@135619|Oceanospirillales 135619|Oceanospirillales D probably involved in intracellular septation ispZ - - ko:K06190 - - - - ko00000 - - - IspA k59_53467_2 160488.PP_4502 6.11e-47 152.0 COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,1S8UC@1236|Gammaproteobacteria,1YYUT@136845|Pseudomonas putida group 1236|Gammaproteobacteria S PFAM YCII-related yciI GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K05527,ko:K09780 - - - - ko00000,ko03000 - - - YCII k59_53467_3 383372.Rcas_0877 1.4e-15 77.0 COG0272@1|root,COG0272@2|Bacteria,2G5TK@200795|Chloroflexi,3756T@32061|Chloroflexia 32061|Chloroflexia L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_680297_1 519989.ECTPHS_07097 9.72e-82 257.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1WXM2@135613|Chromatiales 135613|Chromatiales C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_523307_1 1380356.JNIK01000007_gene504 8.01e-39 141.0 COG4221@1|root,COG4221@2|Bacteria,2HA4H@201174|Actinobacteria 201174|Actinobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1202634_1 1123399.AQVE01000002_gene2344 4.34e-143 429.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,46032@72273|Thiotrichales 72273|Thiotrichales P STAS domain - - - - - - - - - - - - STAS,Sulfate_transp k59_1359200_1 1283300.ATXB01000001_gene253 3.95e-19 86.3 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1XEN4@135618|Methylococcales 135618|Methylococcales M Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process dsbC - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_53490_2 7719.XP_002125844.1 4.21e-81 254.0 COG5285@1|root,KOG3290@2759|Eukaryota,38EX9@33154|Opisthokonta,3B9VM@33208|Metazoa,3CV1M@33213|Bilateria,488Y9@7711|Chordata 33208|Metazoa I phytanoyl-CoA dioxygenase activity PHYH GO:0001561,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006103,GO:0006605,GO:0006625,GO:0006629,GO:0006631,GO:0006720,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0008198,GO:0009056,GO:0009062,GO:0009987,GO:0015031,GO:0015833,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016705,GO:0016706,GO:0019395,GO:0019752,GO:0030258,GO:0031406,GO:0031907,GO:0031974,GO:0032787,GO:0033036,GO:0033365,GO:0034440,GO:0034613,GO:0036094,GO:0042579,GO:0042886,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043648,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046395,GO:0046872,GO:0046907,GO:0046914,GO:0048037,GO:0048244,GO:0051179,GO:0051186,GO:0051213,GO:0051234,GO:0051641,GO:0051649,GO:0055114,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072329,GO:0072594,GO:0072662,GO:0072663,GO:0097089,GO:1901575 1.14.11.18 ko:K00477 ko04146,map04146 - - - ko00000,ko00001,ko01000 - - - PhyH k59_732340_1 246197.MXAN_5605 1.42e-48 174.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,42MG2@68525|delta/epsilon subdivisions,2WJ01@28221|Deltaproteobacteria,2YTX5@29|Myxococcales 28221|Deltaproteobacteria D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_732340_2 439235.Dalk_3133 2.05e-86 278.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,42MJY@68525|delta/epsilon subdivisions,2WJAQ@28221|Deltaproteobacteria,2MHTV@213118|Desulfobacterales 28221|Deltaproteobacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - AlaDh_PNT_C,FAD_binding_3,Mur_ligase_C,Mur_ligase_M,NAD_binding_8 k59_732340_3 880072.Desac_0600 7.98e-106 317.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,42MCP@68525|delta/epsilon subdivisions,2WJDS@28221|Deltaproteobacteria,2MQC4@213462|Syntrophobacterales 28221|Deltaproteobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - iAF987.Gmet_0409 Glycos_transf_4,MraY_sig1 k59_575605_1 439235.Dalk_1318 2.04e-58 183.0 COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,43BHF@68525|delta/epsilon subdivisions,2WQUJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_1463628_1 1192034.CAP_5040 1.04e-93 293.0 COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1MXA1@1224|Proteobacteria,42PXZ@68525|delta/epsilon subdivisions,2X667@28221|Deltaproteobacteria,2Z33M@29|Myxococcales 28221|Deltaproteobacteria P Substrate binding domain of ABC-type glycine betaine transport system - - - ko:K05845,ko:K05846 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1,OpuAC k59_1306709_1 1229909.NSED_09180 2.47e-165 469.0 COG0006@1|root,arCOG01000@2157|Archaea,41T14@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the peptidase M24B family - - 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_1098008_1 330214.NIDE2031 3.93e-102 305.0 COG1980@1|root,COG1980@2|Bacteria 2|Bacteria G fructose-bisphosphate aldolase activity fbp - 3.1.3.11,4.1.2.13 ko:K01622 ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00003 R00762,R01068,R01070,R02568,R04780 RC00017,RC00438,RC00439 ko00000,ko00001,ko00002,ko01000 - - - FBPase_3 k59_575612_2 765914.ThisiDRAFT_0497 1.49e-10 63.2 COG4968@1|root,COG4968@2|Bacteria,1NAXM@1224|Proteobacteria 1224|Proteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K02459 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_1464448_1 1380391.JIAS01000017_gene453 1.43e-117 367.0 COG0160@1|root,COG2334@1|root,COG0160@2|Bacteria,COG2334@2|Bacteria,1MX0Y@1224|Proteobacteria,2TRAZ@28211|Alphaproteobacteria,2JRF7@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - APH,Aminotran_3,Peptidase_M23 k59_681185_1 1496688.ER33_15295 3.78e-07 49.7 2A1SJ@1|root,30Q19@2|Bacteria,1GJH3@1117|Cyanobacteria,22TVM@167375|Cyanobium 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_681185_2 268746.Q58MP5_BPPRM 2.16e-49 161.0 4QB1K@10239|Viruses,4QPBK@28883|Caudovirales,4QI9B@10662|Myoviridae 10662|Myoviridae S Gene 25-like lysozyme - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098025 - - - - - - - - - - - k59_576170_1 1500301.JQMF01000027_gene2927 7.85e-40 144.0 COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TT8C@28211|Alphaproteobacteria,4BDRU@82115|Rhizobiaceae 28211|Alphaproteobacteria C Luciferase-like monooxygenase MA20_04750 - 1.14.13.162 ko:K21731 - - - - ko00000,ko01000 - - - Bac_luciferase k59_471509_1 760192.Halhy_1845 8.57e-12 70.9 COG1960@1|root,COG1960@2|Bacteria,4NEKJ@976|Bacteroidetes,1INZ7@117747|Sphingobacteriia 976|Bacteroidetes I acyl-CoA dehydrogenase gcdH - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_733111_1 436308.Nmar_0260 1.9e-18 78.2 COG2142@1|root,arCOG04162@2157|Archaea,41SRA@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinate dehydrogenase/Fumarate reductase transmembrane subunit - - - ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_733111_2 436308.Nmar_0261 5.88e-74 227.0 COG0479@1|root,arCOG00962@2157|Archaea,41SAW@651137|Thaumarchaeota 651137|Thaumarchaeota C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein - - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 k59_941725_1 1121468.AUBR01000012_gene2572 6.77e-53 181.0 COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,42FIY@68295|Thermoanaerobacterales 186801|Clostridia G PFAM ROK family protein glcK - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS10220 ROK k59_785641_1 1380394.JADL01000007_gene4630 1.27e-96 309.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria 1224|Proteobacteria C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_54397_1 314285.KT71_18736 1.86e-08 61.2 COG1404@1|root,COG1520@1|root,COG3209@1|root,COG3291@1|root,COG3391@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria 1236|Gammaproteobacteria M rhs family - - - - - - - - - - - - RHS_repeat k59_681192_1 266264.Rmet_4145 1.48e-12 72.8 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VJJD@28216|Betaproteobacteria,1K3WS@119060|Burkholderiaceae 28216|Betaproteobacteria C CoA-transferase family III - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_262965_1 1207063.P24_09936 6.65e-29 113.0 COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,2TSXR@28211|Alphaproteobacteria,2JR83@204441|Rhodospirillales 204441|Rhodospirillales S VWA domain containing CoxE-like protein - - - ko:K07161 - - - - ko00000 - - - VWA_CoxE k59_262965_2 1207063.P24_09931 2.55e-44 153.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TREB@28211|Alphaproteobacteria,2JQDG@204441|Rhodospirillales 204441|Rhodospirillales S AAA domain (dynein-related subfamily) - - - - - - - - - - - - AAA,AAA_5 k59_471514_1 5722.XP_001320581.1 1.3e-23 105.0 2CRJK@1|root,2R89C@2759|Eukaryota 2759|Eukaryota S DNA polymerase type B, organellar and viral - - - - - - - - - - - - DNA_pol_B_2 k59_1464459_1 686340.Metal_1832 1.89e-103 333.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1XDT8@135618|Methylococcales 135618|Methylococcales L DEAD DEAH box - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_1516004_1 448385.sce0197 1.52e-42 158.0 COG3857@1|root,COG3857@2|Bacteria 2|Bacteria L exonuclease activity addB - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - Exonuc_V_gamma,PDDEXK_1,UvrD_C k59_889893_1 637389.Acaty_c2139 4.45e-38 140.0 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,2NCCP@225057|Acidithiobacillales 225057|Acidithiobacillales S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_54415_1 472759.Nhal_2772 2.1e-17 78.6 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria,1WYHM@135613|Chromatiales 135613|Chromatiales J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_54415_2 429009.Adeg_1704 1.05e-12 69.3 COG1550@1|root,COG2087@1|root,COG1550@2|Bacteria,COG2087@2|Bacteria,1V6F8@1239|Firmicutes,24JF6@186801|Clostridia,42G03@68295|Thermoanaerobacterales 186801|Clostridia H cobalbumin biosynthesis protein cobU - 2.7.1.156,2.7.7.62 ko:K02231 ko00860,ko01100,map00860,map01100 M00122 R05221,R05222,R06558 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - CobU k59_1046493_1 1419583.V466_01975 2.29e-64 218.0 COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,1RMMI@1236|Gammaproteobacteria,1YRVB@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain pilS - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_941743_1 189753.AXAS01000084_gene6056 4.83e-30 122.0 COG2114@1|root,COG3629@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,BTAD,DZR,Guanylate_cyc,SAM_1,Trans_reg_C k59_576195_2 330214.NIDE0357 4.08e-78 247.0 COG3034@1|root,COG3034@2|Bacteria,3J19Y@40117|Nitrospirae 40117|Nitrospirae S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD k59_1046502_1 1288826.MSNKSG1_04461 1.71e-33 130.0 COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,46511@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 1.3.1.12,1.3.1.43,2.5.1.19 ko:K00210,ko:K00220,ko:K00800 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00022,M00025,M00040 R00732,R01728,R03460 RC00125,RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase,PDH k59_1046502_2 765913.ThidrDRAFT_0048 6.22e-29 113.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1WXIX@135613|Chromatiales 135613|Chromatiales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_54426_1 395493.BegalDRAFT_1255 2.2e-109 337.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,45ZPV@72273|Thiotrichales 72273|Thiotrichales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_54426_2 1123270.ATUR01000010_gene1892 1.22e-15 74.3 COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,2TSUP@28211|Alphaproteobacteria,2K0J4@204457|Sphingomonadales 204457|Sphingomonadales L Uracil-DNA glycosylase - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1324_1 1121904.ARBP01000005_gene4837 1.43e-06 55.1 COG3356@1|root,COG3356@2|Bacteria,4NH6U@976|Bacteroidetes,47NFZ@768503|Cytophagia 976|Bacteroidetes S PFAM Neutral alkaline nonlysosomal ceramidase - - - - - - - - - - - - Ceramidase_alk k59_733142_1 1048339.KB913029_gene947 2.21e-08 56.2 COG2030@1|root,COG2030@2|Bacteria,2GJJI@201174|Actinobacteria,4EV8M@85013|Frankiales 201174|Actinobacteria I N-terminal half of MaoC dehydratase htdY - - - - - - - - - - - MaoC_dehydrat_N,MaoC_dehydratas k59_1411824_1 1304888.ATWF01000001_gene1893 2.27e-05 53.1 COG4972@1|root,COG4972@2|Bacteria,2GF79@200930|Deferribacteres 200930|Deferribacteres NU Type IV pilus assembly protein PilM; - - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_785681_2 1336233.JAEH01000025_gene1084 1.32e-52 178.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,2QAEN@267890|Shewanellaceae 1236|Gammaproteobacteria S PFAM YicC N-terminal domain protein yicC GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575 - - - - - - - - - - DUF1732,YicC_N k59_419653_1 396588.Tgr7_1536 4.78e-88 268.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1WWHV@135613|Chromatiales 135613|Chromatiales E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_837567_1 1232410.KI421415_gene3017 2.11e-58 197.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,42NA6@68525|delta/epsilon subdivisions,2WIMU@28221|Deltaproteobacteria,43SCK@69541|Desulfuromonadales 28221|Deltaproteobacteria S GTP-binding GTPase Middle Region hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_419655_1 1144325.PMI22_00801 7.78e-37 134.0 COG2045@1|root,COG2045@2|Bacteria,1N3KG@1224|Proteobacteria,1SGMF@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the ComB family - - 3.1.3.71 ko:K05979 ko00680,ko01120,map00680,map01120 M00358 R05789 RC00428 ko00000,ko00001,ko00002,ko01000 - - - 2-ph_phosp k59_576207_1 686340.Metal_0362 9.07e-44 158.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1XDU2@135618|Methylococcales 135618|Methylococcales H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis ubiD - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_1307378_1 1229909.NSED_08165 8.14e-110 337.0 COG1048@1|root,arCOG01697@2157|Archaea,41SE6@651137|Thaumarchaeota 651137|Thaumarchaeota C aconitate hydratase - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1411832_1 1123368.AUIS01000026_gene1464 7.73e-111 342.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,2NBVQ@225057|Acidithiobacillales 225057|Acidithiobacillales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1046524_1 4909.A0A099NYB9 9.85e-30 122.0 COG2440@1|root,KOG3519@1|root,KOG2415@2759|Eukaryota,KOG3519@2759|Eukaryota,38H8R@33154|Opisthokonta,3NY0G@4751|Fungi,3QQD7@4890|Ascomycota,3RT3Z@4891|Saccharomycetes 4751|Fungi C Saccharomyces cerevisiae YOR356w - GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0006116,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009117,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019362,GO:0019637,GO:0019674,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0046483,GO:0046496,GO:0048037,GO:0048038,GO:0048039,GO:0051186,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0055114,GO:0070013,GO:0071704,GO:0072524,GO:0098573,GO:0098798,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_576212_1 330214.NIDE3944 1.43e-74 235.0 COG0577@1|root,COG0577@2|Bacteria,3J0EW@40117|Nitrospirae 40117|Nitrospirae V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_210753_1 292459.STH1922 5.34e-24 99.4 COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,248U7@186801|Clostridia 186801|Clostridia E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_210753_2 1479239.JQMU01000001_gene1107 7.7e-100 301.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria,2K03K@204457|Sphingomonadales 204457|Sphingomonadales F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_54468_1 1131269.AQVV01000007_gene1066 6.85e-52 171.0 COG0175@1|root,COG0175@2|Bacteria 2|Bacteria EH sulfate reduction cysH GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114 1.7.7.1,1.8.4.10,1.8.4.8,2.7.1.25 ko:K00366,ko:K00390,ko:K00860 ko00230,ko00910,ko00920,ko01100,ko01120,map00230,map00910,map00920,map01100,map01120 M00176,M00531 R00509,R00790,R02021,R04928 RC00002,RC00007,RC00078,RC00176,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_161961_2 382359.Q0QZ38_BPSYS 1.61e-28 103.0 4QEK3@10239|Viruses,4QZMA@35237|dsDNA viruses no RNA stage,4QREW@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_161961_3 1589733.A0A0C5AMW7_9CAUD 5.29e-11 67.0 4QBNS@10239|Viruses,4QU05@28883|Caudovirales,4QK7T@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1104540_1 1207063.P24_16030 9.93e-29 112.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2UR9F@28211|Alphaproteobacteria,2JT0R@204441|Rhodospirillales 204441|Rhodospirillales S protein conserved in bacteria - - - - - - - - - - - - TctC k59_1312965_1 1123376.AUIU01000014_gene641 3.15e-08 56.6 COG1008@1|root,COG1008@2|Bacteria,3J0EQ@40117|Nitrospirae 40117|Nitrospirae C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1262880_1 1423734.JCM14202_3490 1.33e-24 110.0 COG0765@1|root,COG0834@1|root,COG0765@2|Bacteria,COG0834@2|Bacteria,1TPM3@1239|Firmicutes,4HAS2@91061|Bacilli,3F48Y@33958|Lactobacillaceae 91061|Bacilli P ABC transporter permease arpJ - - ko:K02029,ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - iSB619.SA_RS09465 BPD_transp_1,SBP_bac_3 k59_895604_2 196367.JNFG01000047_gene1400 9.03e-59 189.0 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,1K3K2@119060|Burkholderiaceae 28216|Betaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_1573823_2 290398.Csal_1273 1.31e-33 120.0 COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,1S6IB@1236|Gammaproteobacteria,1XK71@135619|Oceanospirillales 135619|Oceanospirillales S ATPase or kinase - - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k59_895607_1 644548.SCNU_11740 2.81e-54 182.0 COG1960@1|root,COG1960@2|Bacteria,2GIXS@201174|Actinobacteria,4GADN@85026|Gordoniaceae 201174|Actinobacteria C Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_478252_3 1229909.NSED_01475 1.01e-11 63.5 COG0500@1|root,arCOG01631@2157|Archaea,41SJC@651137|Thaumarchaeota 651137|Thaumarchaeota Q RNA methylase - - - - - - - - - - - - DOT1 k59_1105371_1 926560.KE387023_gene2058 7e-14 70.1 COG2020@1|root,COG2020@2|Bacteria 2|Bacteria O methyltransferase activity - - - - - - - - - - - - PEMT k59_1105371_2 1122612.AUBA01000007_gene1123 5.07e-46 153.0 COG0346@1|root,COG0346@2|Bacteria,1N1D4@1224|Proteobacteria,2VEQX@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_1418470_1 1215092.PA6_008_00540 2.07e-69 224.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1YENE@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_530343_1 90813.JQMT01000001_gene1246 3.27e-75 243.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,45ZZ8@72273|Thiotrichales 72273|Thiotrichales J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_162829_1 1177154.Y5S_03650 5.68e-21 91.3 COG2885@1|root,COG2885@2|Bacteria,1MWHF@1224|Proteobacteria,1S1AU@1236|Gammaproteobacteria,1XR3J@135619|Oceanospirillales 1236|Gammaproteobacteria M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA k59_162829_2 709986.Deima_2024 9.2e-20 86.3 COG0071@1|root,COG0071@2|Bacteria,1WJV5@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O Belongs to the small heat shock protein (HSP20) family ibpA - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_1520348_1 160492.XF_0580 6.66e-40 145.0 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1SWJN@1236|Gammaproteobacteria,1X61K@135614|Xanthomonadales 135614|Xanthomonadales F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_1574703_1 47763.JNZA01000007_gene4789 1.68e-26 103.0 COG2606@1|root,COG2606@2|Bacteria,2IKUX@201174|Actinobacteria 201174|Actinobacteria S YbaK prolyl-tRNA synthetase associated region - - - - - - - - - - - - tRNA_edit k59_1574703_2 1192034.CAP_7003 2.09e-166 478.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,42M67@68525|delta/epsilon subdivisions,2WJQX@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Cys Met metabolism - - 2.5.1.48,4.4.1.11,4.4.1.8 ko:K01739,ko:K01760,ko:K01761 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_426135_1 765912.Thimo_1052 4.89e-212 603.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1WW8W@135613|Chromatiales 135613|Chromatiales I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1627557_1 335543.Sfum_2689 3.44e-120 368.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,2MQ5F@213462|Syntrophobacterales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_269506_1 444878.E3SR49_9CAUD 1.45e-64 200.0 4QGRU@10239|Viruses,4QTMP@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1053068_1 1198232.CYCME_1299 2.22e-101 318.0 28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,1RN0X@1236|Gammaproteobacteria,461PJ@72273|Thiotrichales 72273|Thiotrichales M Fatty acid cis/trans isomerase (CTI) - - - - - - - - - - - - CTI k59_793987_1 686340.Metal_1630 2.93e-87 271.0 COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria,1XEVC@135618|Methylococcales 135618|Methylococcales S Domain of unknown function (DUF4478) - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - DUF3412,DUF4478,Lysine_decarbox k59_1472061_1 1191523.MROS_0712 7.39e-91 296.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria 2|Bacteria E L-glutamate biosynthetic process gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_530360_1 1120963.KB894505_gene3705 5.97e-29 114.0 COG2755@1|root,COG2755@2|Bacteria,1NAAJ@1224|Proteobacteria,1SK9B@1236|Gammaproteobacteria 1236|Gammaproteobacteria E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - Lipase_GDSL k59_1418494_1 1385517.N800_13180 1.07e-66 229.0 COG2373@1|root,COG4932@1|root,COG2373@2|Bacteria,COG4932@2|Bacteria,1QZFW@1224|Proteobacteria 1224|Proteobacteria M domain protein - - - - - - - - - - - - DUF11,SdrD_B k59_1366362_1 1304865.JAGF01000001_gene3756 2.12e-12 70.1 COG0842@1|root,COG0842@2|Bacteria,2GVC2@201174|Actinobacteria 201174|Actinobacteria V transport, permease protein - - - ko:K09694 ko02010,map02010 M00252 - - ko00000,ko00001,ko00002,ko02000 3.A.1.102 - - ABC2_membrane k59_739303_1 756272.Plabr_0265 1.57e-61 209.0 COG2211@1|root,COG2211@2|Bacteria,2IY9C@203682|Planctomycetes 203682|Planctomycetes G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1313840_2 1279038.KB907350_gene2929 2.35e-35 134.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria,2JQ2D@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_793995_1 1410633.JHWR01000004_gene410 1.28e-22 98.6 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,27IZZ@186928|unclassified Lachnospiraceae 186801|Clostridia I Enoyl-CoA hydratase/isomerase crt - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_896470_1 118173.KB235914_gene3372 1.2e-51 182.0 COG1834@1|root,COG1915@1|root,COG1834@2|Bacteria,COG1915@2|Bacteria,1G2AU@1117|Cyanobacteria,1H7S0@1150|Oscillatoriales 1117|Cyanobacteria E PFAM LOR SDH bifunctional enzyme conserved region - - - - - - - - - - - - Amidinotransf,Saccharop_dh_N k59_637265_1 391615.ABSJ01000039_gene1793 8.85e-39 142.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,1J50F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J glycyl-tRNA synthetase, alpha subunit glyQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF1260.b3560,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360 tRNA-synt_2e k59_111991_1 493475.GARC_2157 4.61e-24 111.0 COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,1SEWA@1236|Gammaproteobacteria,469S7@72275|Alteromonadaceae 1236|Gammaproteobacteria M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11,SdrD_B k59_794003_1 1125863.JAFN01000001_gene1790 2.07e-45 154.0 COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,42UR1@68525|delta/epsilon subdivisions,2WPQ1@28221|Deltaproteobacteria 28221|Deltaproteobacteria L NUDIX domain - - - - - - - - - - - - NUDIX k59_947857_1 243233.MCA1057 5.35e-48 159.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,1XEUB@135618|Methylococcales 135618|Methylococcales J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_947857_2 1163617.SCD_n02621 1.68e-25 102.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2VHU0@28216|Betaproteobacteria 28216|Betaproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_1053086_1 330214.NIDE2913 5.06e-105 315.0 COG0148@1|root,COG0148@2|Bacteria,3J0DB@40117|Nitrospirae 40117|Nitrospirae G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_111997_1 671143.DAMO_0751 2.16e-62 201.0 COG0638@1|root,COG0638@2|Bacteria,2NQJR@2323|unclassified Bacteria 2|Bacteria O Proteasome subunit prcB GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome k59_896478_1 443255.SCLAV_p0642 1.45e-48 172.0 COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_896478_2 1202768.JROF01000001_gene1622 4.03e-16 80.5 COG0842@1|root,arCOG01467@2157|Archaea,2XT3B@28890|Euryarchaeota,23UKT@183963|Halobacteria 183963|Halobacteria V COG0842 ABC-type multidrug transport system, permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_1313865_1 296591.Bpro_0276 9.39e-96 282.0 COG3576@1|root,COG3576@2|Bacteria,1NBWC@1224|Proteobacteria,2VKQ8@28216|Betaproteobacteria,4AFYK@80864|Comamonadaceae 28216|Betaproteobacteria S Pfam:Pyridox_oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_1366390_2 631454.N177_1753 1.79e-45 161.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,1JNGM@119043|Rhodobiaceae 28211|Alphaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - - - - - - - - - - - - Cpn60_TCP1 k59_689129_1 1324957.K933_02681 1.94e-22 98.2 COG5013@1|root,arCOG01497@2157|Archaea,2XTNG@28890|Euryarchaeota,23TXI@183963|Halobacteria 183963|Halobacteria C Nitrate reductase alpha subunit narG - - ko:K17050 - - - - ko00000,ko02000 5.A.3.8 - - Molybdopterin,Molydop_binding k59_689129_2 1123325.JHUV01000008_gene870 9.47e-06 48.9 COG0664@1|root,COG0664@2|Bacteria,2G4H3@200783|Aquificae 200783|Aquificae K Transcriptional regulator, Crp Fnr family - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_62750_1 331869.BAL199_27861 7.31e-77 239.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - 3.6.3.30 ko:K02010,ko:K02052 ko02010,ko02024,map02010,map02024 M00190,M00193 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10,3.A.1.11 - - ABC_tran,TOBE_2 k59_582650_2 572477.Alvin_0300 1.23e-82 254.0 COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1RNDT@1236|Gammaproteobacteria,1WW02@135613|Chromatiales 135613|Chromatiales GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - Epimerase,NAD_binding_10,RmlD_sub_bind k59_373972_1 935567.JAES01000002_gene626 3.62e-18 76.6 2EGKD@1|root,33ACM@2|Bacteria,1NAVJ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_373972_2 986075.CathTA2_2489 9.1e-29 109.0 COG2050@1|root,COG2050@2|Bacteria,1VA0Y@1239|Firmicutes,4IR16@91061|Bacilli 91061|Bacilli Q Thioesterase superfamily - - - ko:K02614 ko00360,map00360 - R09840 RC00004,RC00014 ko00000,ko00001,ko01000 - - - 4HBT k59_896503_1 395495.Lcho_3298 0.000164 43.1 COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,2VQM0@28216|Betaproteobacteria 28216|Betaproteobacteria K Psort location Cytoplasmic, score 9.97 - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_896503_2 493475.GARC_2329 8.46e-34 132.0 28HKI@1|root,2Z7VC@2|Bacteria,1MW0I@1224|Proteobacteria,1RQ5H@1236|Gammaproteobacteria,469C8@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1211938_1 56780.SYN_02850 1.62e-109 328.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,42M46@68525|delta/epsilon subdivisions,2WJ7G@28221|Deltaproteobacteria,2MQCF@213462|Syntrophobacterales 28221|Deltaproteobacteria F Catalyzes the conversion of dihydroorotate to orotate pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 ko:K00254,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01868,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_1211938_2 391625.PPSIR1_12668 3.92e-08 54.3 COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,42RQK@68525|delta/epsilon subdivisions,2WNJU@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( pyrK - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_582654_1 1157490.EL26_12775 3.23e-25 100.0 COG0528@1|root,COG0528@2|Bacteria,1TPXN@1239|Firmicutes,4H9UB@91061|Bacilli,278X5@186823|Alicyclobacillaceae 91061|Bacilli F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - iSB619.SA_RS06240 AA_kinase k59_582654_2 96561.Dole_0477 1.46e-54 177.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,42NAA@68525|delta/epsilon subdivisions,2WNMN@28221|Deltaproteobacteria,2MJ2A@213118|Desulfobacterales 28221|Deltaproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_62764_1 1208321.D104_10780 9.5e-18 84.7 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1XHRW@135619|Oceanospirillales 135619|Oceanospirillales P Phosphate transport system permease protein - - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_62764_2 465817.ETA_10540 3.64e-17 81.3 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,3X5B8@551|Erwinia 1236|Gammaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015114,GO:0015318,GO:0015399,GO:0015405,GO:0015415,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0035435,GO:0042623,GO:0042626,GO:0043225,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0098660,GO:0098661,GO:0099133 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_217191_1 713586.KB900536_gene1176 1.8e-144 447.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1157261_1 278963.ATWD01000001_gene1097 5.53e-29 114.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,3Y7AG@57723|Acidobacteria,2JKC5@204432|Acidobacteriia 204432|Acidobacteriia L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_32,rve,rve_3 k59_1157261_2 93220.LV28_19325 1.28e-38 130.0 COG2963@1|root,COG2963@2|Bacteria,1RIC2@1224|Proteobacteria,2VTGY@28216|Betaproteobacteria,1K9Z5@119060|Burkholderiaceae 28216|Betaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_739357_1 436308.Nmar_0347 1.02e-107 338.0 COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates - - 2.7.7.6 ko:K13798 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_896510_1 215803.DB30_5796 2.98e-182 535.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2YTUI@29|Myxococcales 28221|Deltaproteobacteria P copper-translocating P-type ATPase copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_322301_1 373903.Hore_17550 1.5e-19 92.0 COG1043@1|root,COG1043@2|Bacteria,1TQRI@1239|Firmicutes,24EGS@186801|Clostridia,3WAIK@53433|Halanaerobiales 186801|Clostridia M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_530427_1 84531.JMTZ01000084_gene1395 1.13e-13 77.4 COG1361@1|root,COG3420@1|root,COG1361@2|Bacteria,COG3420@2|Bacteria 2|Bacteria P alginic acid biosynthetic process - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Beta_helix,Big_5,DUF11,DUF3494 k59_947898_1 349124.Hhal_0734 1.26e-77 260.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1WX1Z@135613|Chromatiales 135613|Chromatiales EQ Hydantoinase B/oxoprolinase - - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_269578_1 1286631.X805_28860 1.1e-34 132.0 COG0845@1|root,COG0845@2|Bacteria,1MV1R@1224|Proteobacteria,2VHJC@28216|Betaproteobacteria,1KMMN@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_D23 k59_1627648_1 1224318.DT73_23300 0.000126 50.8 COG2931@1|root,COG5295@1|root,COG2931@2|Bacteria,COG5295@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - He_PIG,HemolysinCabind,VWA_2 k59_582665_1 1122221.JHVI01000022_gene1208 1.83e-108 326.0 COG0156@1|root,COG0156@2|Bacteria,1WIXA@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide - GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_645277_1 82654.Pse7367_0957 1.42e-14 76.3 COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,1G0BH@1117|Cyanobacteria,1H94Z@1150|Oscillatoriales 1117|Cyanobacteria O PFAM Peptidase family M48 - - - - - - - - - - - - Peptidase_M48,TPR_14 k59_588731_1 1037409.BJ6T_67370 1.39e-11 70.1 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TT4A@28211|Alphaproteobacteria,3JU8B@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_118760_1 444861.E3SPM8_9CAUD 8.79e-09 52.8 4QGWZ@10239|Viruses,4QZS3@35237|dsDNA viruses no RNA stage,4QU3U@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1059225_1 502025.Hoch_4824 9.49e-45 163.0 COG0531@1|root,COG1762@1|root,COG0531@2|Bacteria,COG1762@2|Bacteria,1MXNJ@1224|Proteobacteria,42Q9Q@68525|delta/epsilon subdivisions,2WKCR@28221|Deltaproteobacteria,2YZDF@29|Myxococcales 28221|Deltaproteobacteria E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2,PTS_EIIA_2 k59_588741_1 756276.A0A096VKK6_9VIRU 2.3e-133 392.0 4QAWG@10239|Viruses,4QV6X@35237|dsDNA viruses no RNA stage 10239|Viruses S DnaB-like helicase C terminal domain - - - - - - - - - - - - - k59_1218021_1 1123256.KB907928_gene2130 2.37e-07 52.0 COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,1RRR0@1236|Gammaproteobacteria,1X366@135614|Xanthomonadales 135614|Xanthomonadales O Proteasome subunit - - - ko:K07395 - - - - ko00000 - - - Proteasome k59_1218021_2 765913.ThidrDRAFT_1278 1.85e-36 136.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1WVZB@135613|Chromatiales 135613|Chromatiales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_486488_1 1231336.L248_3157 0.000738 48.1 COG3666@1|root,COG3666@2|Bacteria,1TQQ9@1239|Firmicutes,4H9KK@91061|Bacilli,3F4M8@33958|Lactobacillaceae 91061|Bacilli L Transposase - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_168925_1 713586.KB900536_gene1057 3.7e-73 236.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1WXVV@135613|Chromatiales 135613|Chromatiales J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_1580813_1 247490.KSU1_D0999 3.22e-43 160.0 COG1409@1|root,COG3204@1|root,COG1409@2|Bacteria,COG3204@2|Bacteria,2IYSB@203682|Planctomycetes 203682|Planctomycetes G Purple acid Phosphatase, N-terminal domain - - - - - - - - - - - - Metallophos,Pur_ac_phosph_N k59_536339_1 985054.JQEZ01000003_gene1304 4.5e-76 243.0 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria,4NBWW@97050|Ruegeria 28211|Alphaproteobacteria S N-terminal domain of oxidoreductase MA20_27525 - 1.1.1.1 ko:K00001,ko:K07119 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N_2,ADH_zinc_N k59_536339_2 690585.JNNU01000004_gene4053 1.12e-140 407.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,4BDWB@82115|Rhizobiaceae 28211|Alphaproteobacteria E Cobalamin-independent synthase, Catalytic domain metE - 2.1.1.14,4.4.1.23 ko:K00549,ko:K22363 ko00270,ko00450,ko00625,ko01100,ko01110,ko01230,map00270,map00450,map00625,map01100,map01110,map01230 M00017 R04405,R09365,R11897,R11899 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_2 k59_1372391_1 187272.Mlg_1278 5.47e-92 283.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1WVYA@135613|Chromatiales 135613|Chromatiales H TIGRFAM molybdenum cofactor synthesis - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1218032_1 658086.HMPREF0994_03742 4.22e-50 186.0 2CC7E@1|root,2Z7WG@2|Bacteria,1TTBK@1239|Firmicutes,24D8G@186801|Clostridia 1239|Firmicutes - - - - - - - - - - - - - - - k59_275616_1 1236902.ANAS01000025_gene430 9.66e-70 227.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4EIG2@85012|Streptosporangiales 201174|Actinobacteria C Aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1480068_1 118173.KB235914_gene497 6.73e-81 252.0 COG1085@1|root,COG1085@2|Bacteria,1G1CA@1117|Cyanobacteria,1H82Z@1150|Oscillatoriales 1117|Cyanobacteria C galactose-1-phosphate - - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GalP_UDP_tr_C,GalP_UDP_transf,HIT k59_588762_1 331869.BAL199_22112 4.97e-77 247.0 COG0747@1|root,COG0747@2|Bacteria,1MXQ4@1224|Proteobacteria,2TTIZ@28211|Alphaproteobacteria,4BRB6@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E ABC-type dipeptide transport system, periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_536348_1 1089553.Tph_c29090 8.9e-41 151.0 COG1109@1|root,COG1109@2|Bacteria,1TS6S@1239|Firmicutes,2491F@186801|Clostridia,42FFK@68295|Thermoanaerobacterales 186801|Clostridia G alpha beta alpha domain I manB - 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_432013_1 234831.PSM_A1746 6.09e-05 53.9 COG0210@1|root,COG0210@2|Bacteria,1MVWI@1224|Proteobacteria,1RN1N@1236|Gammaproteobacteria,2Q0UU@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria L COG0210 Superfamily I DNA and RNA helicases helD - 3.6.4.12 ko:K03658 - - - - ko00000,ko01000,ko03400 - - - Helicase_IV_N,UvrD-helicase,UvrD_C,zf-C4_Topoisom k59_1059269_1 1226994.AMZB01000100_gene1008 7.32e-15 73.2 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1YE1N@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECS88_1305.ECS88_0100 LpxC k59_486527_1 1225184.ALXE01000001_gene2939 2.52e-19 88.6 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,3VXJZ@53335|Pantoea 1236|Gammaproteobacteria I Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities fadJ GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c26730,iETEC_1333.ETEC_2476,iEcE24377_1341.EcE24377A_2637,ic_1306.c2886 3HCDH,3HCDH_N,ECH_1 k59_486527_2 525904.Tter_1734 2.98e-18 85.5 COG4243@1|root,COG4243@2|Bacteria 2|Bacteria S quinone binding - - - - - - - - - - - - Thioredoxin_4,VKOR k59_536374_1 1254432.SCE1572_45725 2.04e-66 221.0 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,42N58@68525|delta/epsilon subdivisions,2WIQS@28221|Deltaproteobacteria,2YTWI@29|Myxococcales 28221|Deltaproteobacteria T PhoH-like protein phoH2 - - ko:K06217 - - - - ko00000 - - - PhoH k59_1272113_1 314278.NB231_09623 2.34e-53 193.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1T3U5@1236|Gammaproteobacteria,1X1MF@135613|Chromatiales 135613|Chromatiales M Putative transposase - - - - - - - - - - - - Y2_Tnp k59_645364_1 349124.Hhal_0019 2.67e-16 79.7 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1WWI5@135613|Chromatiales 135613|Chromatiales H Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - - - - - - - - - - HemN_C,Radical_SAM k59_645364_2 1307759.JOMJ01000003_gene1479 1.17e-42 155.0 COG0569@1|root,COG1226@1|root,COG0569@2|Bacteria,COG1226@2|Bacteria,1R4J8@1224|Proteobacteria,42NKU@68525|delta/epsilon subdivisions,2WIRH@28221|Deltaproteobacteria,2M9MG@213115|Desulfovibrionales 28221|Deltaproteobacteria P Ion transport 2 domain protein - - - - - - - - - - - - Ion_trans_2,TrkA_C,TrkA_N k59_223334_1 1380394.JADL01000003_gene5182 5.79e-57 186.0 COG2267@1|root,COG2267@2|Bacteria,1NK3M@1224|Proteobacteria,2TRP8@28211|Alphaproteobacteria,2JS7D@204441|Rhodospirillales 204441|Rhodospirillales I hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_168969_1 1120948.KB903217_gene1644 5e-21 94.4 COG1075@1|root,COG1075@2|Bacteria,2GMZA@201174|Actinobacteria,4DXTV@85010|Pseudonocardiales 201174|Actinobacteria S Putative serine esterase (DUF676) - - - - - - - - - - - - Abhydrolase_1,DUF676,PGAP1 k59_645372_1 1211815.CBYP010000063_gene1913 1.1e-65 217.0 COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria 201174|Actinobacteria I Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta - - - - - - - - - - - - Carboxyl_trans k59_381069_1 555079.Toce_0387 1.07e-68 218.0 COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,42FCC@68295|Thermoanaerobacterales 186801|Clostridia S PFAM 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase - - - ko:K06898 - - - - ko00000 - - - AIRC k59_1426480_1 1005048.CFU_3043 8.55e-10 60.5 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VJ0T@28216|Betaproteobacteria,475KE@75682|Oxalobacteraceae 28216|Betaproteobacteria BQ Histone deacetylase domain acuC - - - - - - - - - - - Hist_deacetyl k59_1426480_2 1237149.C900_04937 1.3e-23 99.4 COG0584@1|root,COG0584@2|Bacteria,4NGI1@976|Bacteroidetes,47MFN@768503|Cytophagia 976|Bacteroidetes C PFAM Glycerophosphoryl diester phosphodiesterase glpQ - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD,Phytase-like k59_850075_1 411467.BACCAP_03768 7.52e-21 95.9 COG0498@1|root,COG0498@2|Bacteria,1UVJ6@1239|Firmicutes,25M4C@186801|Clostridia,26AMD@186813|unclassified Clostridiales 186801|Clostridia E Pyridoxal-phosphate dependent enzyme - - - - - - - - - - - - PALP k59_745380_3 1034943.BN1094_00881 2.27e-07 50.1 2AQ08@1|root,31F55@2|Bacteria,1QCIT@1224|Proteobacteria,1T89I@1236|Gammaproteobacteria,1JGET@118969|Legionellales 118969|Legionellales - - - - - - - - - - - - - - - k59_223343_1 113395.AXAI01000004_gene4271 2.25e-07 57.8 COG2267@1|root,COG2267@2|Bacteria,1MW9H@1224|Proteobacteria,2U1YC@28211|Alphaproteobacteria,3JUEG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_118863_1 420324.KI911970_gene1564 6.06e-114 348.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1426490_1 1229909.NSED_01285 1.3e-125 357.0 COG0377@1|root,arCOG01554@2157|Archaea,41S6D@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the complex I 20 kDa subunit family - - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_802463_1 1040986.ATYO01000016_gene927 2.02e-110 328.0 COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2U0HR@28211|Alphaproteobacteria,43R9S@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G Phosphoenolpyruvate phosphomutase - - - - - - - - - - - - PEP_mutase k59_536399_1 228410.NE0361 2.05e-06 48.9 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,371SW@32003|Nitrosomonadales 28216|Betaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_536399_2 744979.R2A130_0200 1.94e-38 139.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2TRP3@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_6739_1 1163617.SCD_n02227 2.16e-80 251.0 COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,2WGKB@28216|Betaproteobacteria 28216|Betaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_1634229_1 396588.Tgr7_2271 7.76e-125 371.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1WW9V@135613|Chromatiales 135613|Chromatiales J TIGRFAM ribonuclease, Rne Rng family - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_902534_1 1089551.KE386572_gene449 1.23e-10 67.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,4BRCV@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_275688_1 391615.ABSJ01000042_gene2275 5.51e-95 310.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1J55M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glutamate synthase domain gltB GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495,iPC815.YPO3557 GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_432074_1 502025.Hoch_2147 4.38e-23 105.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2WIUD@28221|Deltaproteobacteria,2YVAG@29|Myxococcales 28221|Deltaproteobacteria M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_70743_1 96561.Dole_0194 1.21e-13 70.5 COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,43BQI@68525|delta/epsilon subdivisions 1224|Proteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family ddhA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4,1.8.5.3 ko:K00370,ko:K07306,ko:K10700,ko:K16964,ko:K17050 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500,R09501 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.3,5.A.3.8,5.A.3.9 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_70743_2 1192034.CAP_8031 3.17e-05 46.2 COG0667@1|root,COG0667@2|Bacteria,1NWQE@1224|Proteobacteria,42ZW2@68525|delta/epsilon subdivisions,2WVDI@28221|Deltaproteobacteria,2YVXI@29|Myxococcales 28221|Deltaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red,HEAT_2 k59_1219027_1 742159.HMPREF0004_1846 3.26e-98 300.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VJJ7@28216|Betaproteobacteria,3T5C8@506|Alcaligenaceae 28216|Betaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_23,HTH_38,HTH_7,rve k59_1273143_1 105559.Nwat_1523 9.71e-109 349.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_646374_1 1150469.RSPPHO_01095 2.87e-37 139.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2TR63@28211|Alphaproteobacteria,2JQ9U@204441|Rhodospirillales 204441|Rhodospirillales T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_646374_2 663321.REG_0358 5.49e-06 48.9 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,283J9@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria G Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides nagZ - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_1219032_1 316056.RPC_3223 5.19e-27 102.0 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2UFSY@28211|Alphaproteobacteria,3JZEK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20,HTH_5 k59_1219032_2 886379.AEWI01000013_gene2073 4.29e-05 48.5 COG1538@1|root,COG1538@2|Bacteria,4NFTV@976|Bacteroidetes,2FMYV@200643|Bacteroidia,3XJPP@558415|Marinilabiliaceae 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_803445_1 570967.JMLV01000004_gene705 2.53e-09 63.5 COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,2VAG8@28211|Alphaproteobacteria,2JRZ9@204441|Rhodospirillales 204441|Rhodospirillales S Virulence factor BrkB - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_803445_2 590998.Celf_2371 1.75e-06 53.9 COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4F2PZ@85016|Cellulomonadaceae 201174|Actinobacteria L Helix-hairpin-helix motif comEA - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3,SLBB k59_646376_1 1207063.P24_11802 8.67e-101 303.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2TRUK@28211|Alphaproteobacteria,2JPUE@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the peptidase M20A family. ArgE subfamily argE - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_1219034_1 1236959.BAMT01000020_gene740 2.4e-29 122.0 COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2VKDG@28216|Betaproteobacteria,2KNFW@206350|Nitrosomonadales 206350|Nitrosomonadales G Glycosyl hydrolase 36 superfamily, catalytic domain - - - - - - - - - - - - Glyco_hydro_36,Glyco_transf_36,Glycoamylase k59_1581698_1 84531.JMTZ01000021_gene3832 5.73e-20 90.9 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1X3X2@135614|Xanthomonadales 135614|Xanthomonadales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_1581698_2 1158182.KB905023_gene1337 6.56e-17 75.9 COG3116@1|root,COG3116@2|Bacteria,1NI3C@1224|Proteobacteria,1SGSB@1236|Gammaproteobacteria,1WZ00@135613|Chromatiales 135613|Chromatiales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsL - - ko:K03586 - - - - ko00000,ko03036 - - - FtsL k59_1581698_3 1249627.D779_1225 3.28e-80 250.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1WX5B@135613|Chromatiales 135613|Chromatiales J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_487592_1 426117.M446_5885 1.43e-06 55.5 COG2114@1|root,COG3899@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,COG3903@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,1JR57@119045|Methylobacteriaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1,SAM_2 k59_433015_1 1122164.JHWF01000016_gene1563 2.97e-74 237.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1JCJV@118969|Legionellales 118969|Legionellales G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_646410_2 502025.Hoch_5323 4.56e-27 102.0 COG0346@1|root,COG0346@2|Bacteria,1RA9H@1224|Proteobacteria,439N8@68525|delta/epsilon subdivisions,2X4ZH@28221|Deltaproteobacteria,2YZW4@29|Myxococcales 28221|Deltaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase_4 k59_224127_1 765913.ThidrDRAFT_3273 4.28e-56 187.0 COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,1RP5X@1236|Gammaproteobacteria,1WVX3@135613|Chromatiales 135613|Chromatiales S PFAM Uncharacterised conserved protein UCP029693 - - - - - - - - - - - - DUF2333 k59_1273187_1 391615.ABSJ01000026_gene151 6.18e-64 208.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,1J4Y7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009014,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_1112313_1 290397.Adeh_0928 7.79e-51 174.0 COG0003@1|root,COG0003@2|Bacteria,1PMWP@1224|Proteobacteria,42RUR@68525|delta/epsilon subdivisions,2WNEE@28221|Deltaproteobacteria,2YUU4@29|Myxococcales 28221|Deltaproteobacteria D AAA domain agmR - - - - - - - - - - - ArsA_ATPase k59_1007243_1 572265.HDEF_0343 6.24e-07 56.6 COG3297@1|root,COG3297@2|Bacteria,1PPZ2@1224|Proteobacteria,1SWSM@1236|Gammaproteobacteria,283P9@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria U GspL periplasmic domain - - - ko:K02461 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - GspL_C,T2SSL k59_954903_2 1212548.B381_01065 2.39e-29 104.0 COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,1SC8Q@1236|Gammaproteobacteria,1Z3IG@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C Rubredoxin rubA - 1.18.1.1 ko:K05297 ko00071,map00071 - R02000 - ko00000,ko00001,ko01000 - - - Rubredoxin k59_954903_3 1286093.C266_22635 3.63e-06 48.5 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2VHEU@28216|Betaproteobacteria,1K3QR@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_1434155_3 472759.Nhal_1964 1.17e-08 55.8 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1WVVA@135613|Chromatiales 135613|Chromatiales NU FimV C-terminal - - - ko:K08086 - - - - ko00000 - - - TPR_19 k59_908544_1 1005994.GTGU_01440 2.29e-28 117.0 COG2887@1|root,COG2887@2|Bacteria,1QEBA@1224|Proteobacteria,1RSK2@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Protein of unknown function (DUF2800) - - - - - - - - - - - - DUF2800 k59_1377940_1 118168.MC7420_5695 6.43e-27 108.0 COG0297@1|root,COG0297@2|Bacteria,1G3UW@1117|Cyanobacteria,1HAE0@1150|Oscillatoriales 1117|Cyanobacteria G Sucrose synthase - - 2.4.1.14 ko:K00696 ko00500,ko01100,map00500,map01100 - R00766 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000 - GT4 - Glyco_trans_4_4,Glycos_transf_1 k59_1377940_2 1499967.BAYZ01000161_gene372 2.61e-59 192.0 COG0572@1|root,COG0572@2|Bacteria,2NRHW@2323|unclassified Bacteria 2|Bacteria F Phosphoribulokinase / Uridine kinase family - - 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 - - - AAA_18,AAA_33,Hydrolase_like,NTP_transferase,PRK,RNA_lig_T4_1 k59_126019_1 570967.JMLV01000008_gene1425 1.57e-39 138.0 COG1595@1|root,COG1595@2|Bacteria,1NRNT@1224|Proteobacteria,2TT5K@28211|Alphaproteobacteria,2JZNH@204441|Rhodospirillales 204441|Rhodospirillales K Sigma-70, region 4 - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 k59_541990_1 1056816.JAFQ01000004_gene4078 1.36e-05 47.0 COG0596@1|root,COG0596@2|Bacteria,2HHT8@201174|Actinobacteria,4G09S@85025|Nocardiaceae 201174|Actinobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_6 k59_541990_2 1037409.BJ6T_69390 1.97e-33 122.0 COG2030@1|root,COG2030@2|Bacteria,1RGUP@1224|Proteobacteria,2UHVT@28211|Alphaproteobacteria 28211|Alphaproteobacteria I MaoC like domain - - - - - - - - - - - - MaoC_dehydratas k59_541990_3 1265310.CCBD010000069_gene412 1.18e-11 64.7 COG3386@1|root,COG3386@2|Bacteria,2GNV1@201174|Actinobacteria,236DC@1762|Mycobacteriaceae 201174|Actinobacteria G PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - SGL k59_1065348_1 89187.ISM_12900 2.5e-40 149.0 COG0265@1|root,COG1716@1|root,COG0265@2|Bacteria,COG1716@2|Bacteria,1NT6K@1224|Proteobacteria,2UPAI@28211|Alphaproteobacteria 28211|Alphaproteobacteria OT Trypsin-like peptidase domain - - - - - - - - - - - - Trypsin_2 k59_653211_1 1128427.KB904821_gene1928 4.06e-20 93.6 COG0598@1|root,COG0598@2|Bacteria,1G1AG@1117|Cyanobacteria,1H99G@1150|Oscillatoriales 1117|Cyanobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_228989_1 330214.NIDE1093 1.75e-21 87.8 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator - - - - - - - - - - - - AroM,GerE k59_810343_1 1049564.TevJSym_aa02130 3.02e-48 165.0 2B5QC@1|root,31YJX@2|Bacteria,1RIBA@1224|Proteobacteria,1SPMT@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - MotA_ExbB k59_959551_1 1185766.DL1_20105 1.59e-12 65.9 COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2TU5A@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Peroxiredoxin - - - - - - - - - - - - Redoxin k59_959551_2 444878.E3SR96_9CAUD 8.65e-15 66.6 4QD34@10239|Viruses,4QX75@35237|dsDNA viruses no RNA stage,4QSAJ@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1280300_2 1267535.KB906767_gene602 1.11e-40 143.0 COG2220@1|root,COG2220@2|Bacteria,3Y4RK@57723|Acidobacteria,2JM7M@204432|Acidobacteriia 204432|Acidobacteriia S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_3 k59_856253_1 257363.RT0514 2.69e-61 206.0 COG0500@1|root,COG2226@2|Bacteria,1QWA7@1224|Proteobacteria,2TWUC@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG0500 SAM-dependent methyltransferases - - - - - - - - - - - - Methyltransf_12,Methyltransf_31 k59_1377965_1 338966.Ppro_2424 1.1e-14 81.6 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,42NIZ@68525|delta/epsilon subdivisions,2WM5U@28221|Deltaproteobacteria,43T8Z@69541|Desulfuromonadales 28221|Deltaproteobacteria E Domain of unknown function (DUF3488) - - - - - - - - - - - - DUF3488,DUF4129,Transglut_core k59_856258_1 485916.Dtox_2855 1.54e-72 228.0 COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,25EDZ@186801|Clostridia,261N7@186807|Peptococcaceae 186801|Clostridia M Polysaccharide biosynthesis protein - - 5.1.3.2,5.1.3.20,5.1.3.7 ko:K01784,ko:K02473,ko:K03274 ko00052,ko00520,ko00540,ko01100,map00052,map00520,map00540,map01100 M00064,M00361,M00362,M00632 R00291,R00418,R02984,R05176 RC00289,RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase,GDP_Man_Dehyd k59_653255_1 1120936.KB907210_gene5770 1.43e-14 80.5 COG1198@1|root,COG1198@2|Bacteria,2GKES@201174|Actinobacteria,4EHCM@85012|Streptosporangiales 201174|Actinobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - - k59_1587024_1 322710.Avin_15850 1.5e-129 394.0 COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 1.3.1.12,1.3.1.43,2.5.1.19 ko:K00210,ko:K00220,ko:K00800 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00022,M00025,M00040 R00732,R01728,R03460 RC00125,RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase,PDH k59_1587024_2 1046724.KB889875_gene1725 3.03e-18 85.1 COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,46511@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 1.3.1.12,1.3.1.43,2.5.1.19 ko:K00210,ko:K00220,ko:K00800 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00022,M00025,M00040 R00732,R01728,R03460 RC00125,RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase,PDH k59_494477_1 1469245.JFBG01000059_gene2424 7.8e-114 346.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1WWAE@135613|Chromatiales 135613|Chromatiales S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_1323163_2 1229909.NSED_09930 4.36e-45 155.0 COG1794@1|root,arCOG02005@2157|Archaea,41SM4@651137|Thaumarchaeota 651137|Thaumarchaeota M Asp/Glu/Hydantoin racemase - - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_1117289_1 4929.XP_001482077.1 4.06e-34 131.0 COG2021@1|root,2QR3J@2759|Eukaryota,38CHD@33154|Opisthokonta,3NVHE@4751|Fungi,3QM8P@4890|Ascomycota,3RRA8@4891|Saccharomycetes,47AHW@766764|Debaryomycetaceae 4751|Fungi H alpha/beta hydrolase fold cys2 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009066,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1280342_1 330214.NIDE0826 1.61e-121 350.0 COG0226@1|root,COG0226@2|Bacteria,3J0YH@40117|Nitrospirae 2|Bacteria P Evidence 2a Function of homologous gene experimentally demonstrated in an other organism forD - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - CO_dh,PBP_like_2 k59_334253_1 13690.CP98_05260 1.66e-61 204.0 COG3039@1|root,COG3039@2|Bacteria,1R70H@1224|Proteobacteria,2U4GT@28211|Alphaproteobacteria,2K8WF@204457|Sphingomonadales 204457|Sphingomonadales L Transposase or inactivated derivative - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_1323172_1 472759.Nhal_2460 4.58e-07 51.6 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales 135613|Chromatiales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1323172_2 261292.Nit79A3_3476 7.02e-48 169.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,371TQ@32003|Nitrosomonadales 28216|Betaproteobacteria M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_701191_1 9823.ENSSSCP00000004085 4.32e-27 109.0 COG1960@1|root,KOG0140@2759|Eukaryota,38BNR@33154|Opisthokonta,3BCJM@33208|Metazoa,3CV7W@33213|Bilateria,484GK@7711|Chordata,4905F@7742|Vertebrata,3JB1J@40674|Mammalia,4J473@91561|Cetartiodactyla 33208|Metazoa I Medium-chain specific acyl-CoA dehydrogenase ACADM GO:0000062,GO:0000166,GO:0000271,GO:0001889,GO:0003674,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006082,GO:0006091,GO:0006109,GO:0006111,GO:0006112,GO:0006575,GO:0006577,GO:0006578,GO:0006629,GO:0006631,GO:0006635,GO:0006807,GO:0006950,GO:0007275,GO:0007507,GO:0007584,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009062,GO:0009250,GO:0009266,GO:0009409,GO:0009437,GO:0009605,GO:0009628,GO:0009719,GO:0009725,GO:0009791,GO:0009888,GO:0009889,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010675,GO:0010906,GO:0014070,GO:0014706,GO:0015980,GO:0016020,GO:0016042,GO:0016043,GO:0016051,GO:0016054,GO:0016491,GO:0016604,GO:0016607,GO:0016627,GO:0016853,GO:0017076,GO:0019216,GO:0019222,GO:0019254,GO:0019395,GO:0019752,GO:0022607,GO:0030154,GO:0030258,GO:0030424,GO:0030554,GO:0031090,GO:0031323,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033692,GO:0033993,GO:0034440,GO:0034637,GO:0034641,GO:0034645,GO:0035051,GO:0036094,GO:0042221,GO:0042398,GO:0042493,GO:0042594,GO:0042692,GO:0042802,GO:0042995,GO:0043005,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043436,GO:0043933,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0045329,GO:0046395,GO:0046688,GO:0048037,GO:0048513,GO:0048545,GO:0048731,GO:0048732,GO:0048738,GO:0048856,GO:0048869,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051146,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0051791,GO:0051793,GO:0055007,GO:0055114,GO:0060537,GO:0061008,GO:0061061,GO:0062012,GO:0065003,GO:0065007,GO:0070013,GO:0070991,GO:0071704,GO:0071840,GO:0072329,GO:0072359,GO:0080090,GO:0097159,GO:0097164,GO:0097367,GO:0097458,GO:0120025,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901567,GO:1901575,GO:1901576,GO:1901681 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_701191_2 235985.BBPN01000073_gene7191 5.29e-45 159.0 COG1414@1|root,COG1414@2|Bacteria,2GM23@201174|Actinobacteria,2NHGX@228398|Streptacidiphilus 201174|Actinobacteria K helix_turn_helix isocitrate lyase regulation allR - - - - - - - - - - - HTH_IclR,IclR k59_810398_1 485913.Krac_12552 1.4e-07 56.6 COG0842@1|root,COG1131@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,2G7J8@200795|Chloroflexi 200795|Chloroflexi V FHA modulated ABC efflux pump with fused ATPase and integral membrane subunits - - - - - - - - - - - - ABC2_membrane,ABC_tran,FHA k59_810398_2 876044.IMCC3088_1490 1.74e-26 108.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_1166790_1 756272.Plabr_0265 1.58e-38 145.0 COG2211@1|root,COG2211@2|Bacteria,2IY9C@203682|Planctomycetes 203682|Planctomycetes G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_542037_2 1380390.JIAT01000010_gene4327 2.17e-126 369.0 COG2037@1|root,COG2037@2|Bacteria 2|Bacteria H Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT) ffsA GO:0003674,GO:0003824,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0015947,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0030270,GO:0043446,GO:0044237,GO:0044281,GO:0071704 2.3.1.101 ko:K00672 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03390 RC00197,RC00870,RC02881 ko00000,ko00001,ko00002,ko01000 - - - FTR,FTR_C k59_909713_2 246197.MXAN_5916 2.45e-12 70.1 COG0697@1|root,COG0697@2|Bacteria,1N024@1224|Proteobacteria,42NW9@68525|delta/epsilon subdivisions,2WJEJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_543098_1 330214.NIDE1184 2.92e-58 190.0 COG2159@1|root,COG2159@2|Bacteria 2|Bacteria E amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_440118_1 436308.Nmar_0408 9.87e-59 185.0 arCOG08670@1|root,arCOG08670@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - DM13 k59_174694_1 1229909.NSED_02650 1.34e-34 119.0 COG0361@1|root,arCOG01179@2157|Archaea,41SRK@651137|Thaumarchaeota 651137|Thaumarchaeota J Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits - - - ko:K03236 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - eIF-1a k59_174694_2 436308.Nmar_0527 1.36e-36 123.0 COG1278@1|root,arCOG02983@2157|Archaea,41T9B@651137|Thaumarchaeota 651137|Thaumarchaeota K Cold shock protein domain - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_1324031_2 243090.RB1656 8.42e-58 206.0 COG2199@1|root,COG3290@1|root,COG3437@1|root,COG3290@2|Bacteria,COG3437@2|Bacteria,COG3706@2|Bacteria,2IYJM@203682|Planctomycetes 203682|Planctomycetes T GGDEF domain - - - - - - - - - - - - GGDEF,HD,PAS_4 k59_543110_1 1283300.ATXB01000001_gene1758 2.84e-50 162.0 COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria,1XF9T@135618|Methylococcales 135618|Methylococcales NU PFAM Type IV pilus assembly PilZ pilZ - - ko:K02676 - - - - ko00000,ko02035,ko02044 - - - PilZ k59_595896_1 1379698.RBG1_1C00001G1725 1.54e-47 175.0 COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria 2|Bacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrD - - ko:K03296,ko:K18138,ko:K18307 ko01501,ko01503,ko02024,map01501,map01503,map02024 M00644,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.20,2.A.6.2.32 - - ACR_tran k59_1281828_1 1245471.PCA10_55280 4.96e-68 213.0 COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria,1YCTM@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE GO:0000287,GO:0003674,GO:0003824,GO:0004588,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2819,iECIAI39_1322.ECIAI39_4161,iEcSMS35_1347.EcSMS35_3977,iUTI89_1310.UTI89_C4186 Pribosyltran k59_1435699_1 1229909.NSED_09905 5.65e-87 275.0 COG1293@1|root,arCOG01695@2157|Archaea,41SB0@651137|Thaumarchaeota 651137|Thaumarchaeota K Fibronectin-binding protein A N-terminus (FbpA) - - - - - - - - - - - - DUF814,FbpA k59_495987_1 342610.Patl_1680 1.94e-08 61.6 COG2202@1|root,COG3292@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3292@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2Q09Q@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_4,PAS_9,Reg_prop,Y_Y_Y k59_1167661_1 248742.XP_005648541.1 5.01e-31 117.0 COG0214@1|root,KOG1606@2759|Eukaryota,37KWB@33090|Viridiplantae,34H49@3041|Chlorophyta 3041|Chlorophyta H Belongs to the PdxS SNZ family - - 4.3.3.6 ko:K06215 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SOR_SNZ k59_1066497_1 525146.Ddes_0591 1.35e-06 51.2 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,42M0S@68525|delta/epsilon subdivisions,2WITR@28221|Deltaproteobacteria,2M7ZW@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM ABC transporter related - - 3.6.3.21 ko:K02028,ko:K10004 ko02010,ko02020,map02010,map02020 M00230,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.19,3.A.1.3.4 - - ABC_tran k59_1066497_2 543913.D521_0765 1.44e-63 201.0 COG0765@1|root,COG0765@2|Bacteria,1QN80@1224|Proteobacteria,2VPCF@28216|Betaproteobacteria 28216|Betaproteobacteria P Abc transporter tcyB_2 - - ko:K02029,ko:K10009 ko02010,map02010 M00234,M00236 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.10,3.A.1.3.14 - - BPD_transp_1 k59_752413_1 1033802.SSPSH_002092 8.45e-25 103.0 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_752413_2 765914.ThisiDRAFT_1243 1.78e-28 112.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria,1WXIF@135613|Chromatiales 135613|Chromatiales S associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1435709_1 444860.E3SJ03_9CAUD 1e-126 386.0 4QB53@10239|Viruses,4QW98@35237|dsDNA viruses no RNA stage,4QSJ1@28883|Caudovirales,4QK7P@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_80135_1 330214.NIDE0403 2.61e-53 185.0 COG0441@1|root,COG0441@2|Bacteria,3J0F4@40117|Nitrospirae 40117|Nitrospirae J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_SAD k59_496003_1 237368.SCABRO_03724 9.62e-96 297.0 COG1389@1|root,COG1389@2|Bacteria,2J2A8@203682|Planctomycetes 203682|Planctomycetes L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6B - 5.99.1.3 ko:K03167 - - - - ko00000,ko01000,ko03032 - - - HATPase_c,Topo-VIb_trans k59_1226271_1 330214.NIDE0762 8.41e-115 342.0 COG0773@1|root,COG0773@2|Bacteria,3J0D5@40117|Nitrospirae 40117|Nitrospirae M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1118428_1 1121403.AUCV01000012_gene4067 9.62e-09 59.7 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - 3.8.1.5 ko:K01563 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1281867_1 929556.Solca_2745 5.78e-64 205.0 COG0275@1|root,COG0275@2|Bacteria,4NFQB@976|Bacteroidetes,1INNA@117747|Sphingobacteriia 976|Bacteroidetes M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_1489470_2 1090318.ATTI01000001_gene726 2.24e-20 90.5 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2U9QB@28211|Alphaproteobacteria,2K55Y@204457|Sphingomonadales 204457|Sphingomonadales O Belongs to the glutaredoxin family. Monothiol subfamily grxD - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin k59_1435732_1 1229909.NSED_08400 1.35e-30 122.0 arCOG07561@1|root,arCOG07561@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - TSP_3,VWA k59_543147_1 1121374.KB891575_gene1052 1.04e-107 345.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,1RSEQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C indolepyruvate ferredoxin oxidoreductase - - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_543147_2 1159870.KB907784_gene1894 8.17e-45 166.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VN0R@28216|Betaproteobacteria,3T2D1@506|Alcaligenaceae 28216|Betaproteobacteria C Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits - - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_1379142_1 1128427.KB904821_gene1366 0.000694 48.1 COG2931@1|root,COG3291@1|root,COG3391@1|root,COG5276@1|root,COG2931@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG5276@2|Bacteria,1G02E@1117|Cyanobacteria,1H9TQ@1150|Oscillatoriales 1117|Cyanobacteria Q Hemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - Calx-beta,HemolysinCabind,SBBP k59_752444_1 472759.Nhal_1615 1.95e-84 263.0 COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,1RP1B@1236|Gammaproteobacteria,1WZVK@135613|Chromatiales 135613|Chromatiales C Prokaryotic cytochrome b561 - - - ko:K00127 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Ni_hydr_CYTB k59_1281899_1 1192868.CAIU01000019_gene2652 8.88e-130 385.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,43J3W@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q COG1233 Phytoene dehydrogenase and related - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_857433_1 330214.NIDE1955 8.39e-138 419.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria 2|Bacteria S CHAT domain - - - - - - - - - - - - CHAT,TPR_10,TPR_12,TPR_16,TPR_7,TPR_8 k59_80190_1 999549.KI421513_gene2108 2.41e-107 327.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2TSZY@28211|Alphaproteobacteria,27ZH3@191028|Leisingera 28211|Alphaproteobacteria E Glu/Leu/Phe/Val dehydrogenase, dimerisation domain gdh - 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N,Response_reg k59_389623_1 1049564.TevJSym_ad00400 4.84e-34 127.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,1J4YQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0436 Aspartate tyrosine aromatic aminotransferase dapC - 2.6.1.17 ko:K14261,ko:K14267 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1291247_1 444860.E3SJ07_9CAUD 3.48e-12 67.0 4QAQQ@10239|Viruses,4QVZX@35237|dsDNA viruses no RNA stage,4QPBX@28883|Caudovirales,4QIBM@10662|Myoviridae 10662|Myoviridae S T4-like virus tail tube protein gp19 - - - - - - - - - - - - - k59_1291247_2 445686.E3SL62_9CAUD 1.11e-93 291.0 4QBAK@10239|Viruses,4QY34@35237|dsDNA viruses no RNA stage,4QQBQ@28883|Caudovirales,4QIQI@10662|Myoviridae 10662|Myoviridae S Bacteriophage T4-like capsid assembly protein (Gp20) - GO:0005575,GO:0019012 - - - - - - - - - - - k59_1291249_1 1121935.AQXX01000141_gene2024 1.25e-63 209.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,1RQ50@1236|Gammaproteobacteria,1XH84@135619|Oceanospirillales 135619|Oceanospirillales E D-amino acid - - 1.4.3.19 ko:K03153 ko00730,ko01100,map00730,map01100 - R07463 RC01788 ko00000,ko00001,ko01000 - - - DAO k59_505312_1 203119.Cthe_2631 7.66e-34 125.0 COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia,3WIEP@541000|Ruminococcaceae 186801|Clostridia J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_1385385_1 550540.Fbal_1908 1.53e-36 145.0 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria 1236|Gammaproteobacteria P P-type atpase ccoI - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_1498768_1 1215092.PA6_008_01860 1.04e-05 47.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1YFHC@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria P Ammonium Transporter Family amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_1330008_1 1265505.ATUG01000002_gene2754 2.34e-36 138.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,42RFR@68525|delta/epsilon subdivisions,2WJYK@28221|Deltaproteobacteria,2MIFF@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF1732) yicC - - - - - - - - - - - DUF1732,YicC_N k59_1020384_1 330214.NIDE4173 8.17e-93 288.0 COG2220@1|root,COG2220@2|Bacteria 2|Bacteria S N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity - - - - - - - - - - - - Lactamase_B_2,Lactamase_B_3 k59_709092_2 1122599.AUGR01000002_gene3524 9.39e-62 197.0 COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,1S425@1236|Gammaproteobacteria,1XJU2@135619|Oceanospirillales 135619|Oceanospirillales O Belongs to the glutathione peroxidase family - - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_448647_1 1121937.AUHJ01000009_gene1470 5.6e-146 435.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,469GD@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1126306_1 765914.ThisiDRAFT_2097 3.78e-26 104.0 COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1WXDF@135613|Chromatiales 135613|Chromatiales J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit - - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_549966_1 251221.35212249 7.15e-27 103.0 COG0745@1|root,COG0745@2|Bacteria,1G6W5@1117|Cyanobacteria 1117|Cyanobacteria T Response regulator receiver - - - - - - - - - - - - Response_reg k59_135812_1 1266925.JHVX01000007_gene2343 2.32e-45 164.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VISA@28216|Betaproteobacteria,371XU@32003|Nitrosomonadales 28216|Betaproteobacteria C Cysteine-rich domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_8 k59_1330027_1 385682.AFSL01000102_gene63 2.79e-12 66.2 COG2035@1|root,COG2035@2|Bacteria,4NFKI@976|Bacteroidetes,2FPD1@200643|Bacteroidia,3XIX4@558415|Marinilabiliaceae 976|Bacteroidetes S Domain of unknown function (DUF368) - - - ko:K08974 - - - - ko00000 - - - DUF368 k59_1330027_2 395493.BegalDRAFT_3383 7.2e-86 265.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,45ZXW@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_13573_1 420324.KI912061_gene6197 5.5e-26 109.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,1JR57@119045|Methylobacteriaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,Abhydrolase_1,Guanylate_cyc,TPR_4 k59_137133_1 448385.sce3157 1.04e-78 254.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42MYN@68525|delta/epsilon subdivisions,2WIND@28221|Deltaproteobacteria,2YUEV@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - GATase,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1021353_1 870187.Thini_0776 2.85e-54 175.0 COG2230@1|root,COG2230@2|Bacteria,1QVX6@1224|Proteobacteria,1T2MM@1236|Gammaproteobacteria,4628Q@72273|Thiotrichales 72273|Thiotrichales M Protein of unknown function (DUF938) - - - - - - - - - - - - DUF938 k59_551003_2 1396858.Q666_06665 0.000866 46.6 COG3391@1|root,COG3391@2|Bacteria,1QX6H@1224|Proteobacteria,1T3DD@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Thrombospondin type 3 repeat - - - - - - - - - - - - TSP_3 k59_865206_1 197221.22295620 9.69e-18 86.7 COG1612@1|root,COG1612@2|Bacteria,1G08Q@1117|Cyanobacteria 1117|Cyanobacteria O cytochrome oxidase assembly ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_1075614_1 1209072.ALBT01000047_gene454 1.47e-76 245.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1FGTN@10|Cellvibrio 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_344334_1 264462.Bd2151 6.8e-47 167.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,43DIW@68525|delta/epsilon subdivisions,2MUTK@213481|Bdellovibrionales,2X8Q7@28221|Deltaproteobacteria 213481|Bdellovibrionales C Catalyzes the reversible hydration of fumarate to (S)- malate fumB - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_292150_1 595494.Tola_2147 9.66e-50 181.0 COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,1RMQ1@1236|Gammaproteobacteria,1Y43X@135624|Aeromonadales 135624|Aeromonadales L DNA polymerase polB - 2.7.7.7 ko:K02336 - - - - ko00000,ko01000,ko03400 - - - DNA_pol_B,DNA_pol_B_exo1 k59_1075615_1 1124983.PFLCHA0_c08110 2.48e-118 347.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1RQ31@1236|Gammaproteobacteria,1YUNX@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria E Membrane dipeptidase (Peptidase family M19) HA62_13665 - - - - - - - - - - - Peptidase_M19 k59_137167_2 330214.NIDE0970 7.28e-95 283.0 COG1013@1|root,COG1013@2|Bacteria,3J0Z2@40117|Nitrospirae 40117|Nitrospirae C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_968766_2 7739.XP_002590381.1 7.9e-18 82.4 COG4992@1|root,KOG1401@2759|Eukaryota,38GP9@33154|Opisthokonta,3BSXV@33208|Metazoa,3DA60@33213|Bilateria,48KD0@7711|Chordata 33208|Metazoa E Aminotransferase class-III - - - - - - - - - - - - Aminotran_3 k59_1236342_1 396588.Tgr7_1541 2.48e-93 286.0 COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1WX54@135613|Chromatiales 135613|Chromatiales E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_1330923_1 83406.HDN1F_20090 2.5e-86 286.0 COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,1T2GI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.7.5.1,1.8.5.3 ko:K00370,ko:K07306,ko:K17050 ko00910,ko00920,ko01120,ko02020,map00910,map00920,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497,R09501 RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.3,5.A.3.8 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_760130_1 237368.SCABRO_02249 2.56e-52 167.0 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity - - - - - - - - - - - - Glyoxalase,Glyoxalase_2 k59_137175_1 987059.RBXJA2T_13966 1.7e-130 375.0 COG0447@1|root,COG0447@2|Bacteria,1QTZ2@1224|Proteobacteria,2VJ36@28216|Betaproteobacteria,1KKKJ@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) menB - 4.1.3.36 ko:K01661,ko:K07536 ko00130,ko00362,ko01100,ko01110,ko01120,ko01220,map00130,map00362,map01100,map01110,map01120,map01220 M00116,M00540 R05592,R07263 RC01429,RC01923 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_137175_2 1049564.TevJSym_ac00200 5.41e-15 75.5 COG1575@1|root,COG1575@2|Bacteria,1PKCZ@1224|Proteobacteria,1SXAN@1236|Gammaproteobacteria,1J9HU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H UbiA prenyltransferase family - - - - - - - - - - - - UbiA k59_344349_1 111781.Lepto7376_4064 1.75e-43 163.0 COG0577@1|root,COG0577@2|Bacteria,1G04T@1117|Cyanobacteria 1117|Cyanobacteria V ABC-type transport system involved in lipoprotein release permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1536287_1 1283300.ATXB01000001_gene42 1.78e-60 201.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RQMD@1236|Gammaproteobacteria,1XGZF@135618|Methylococcales 135618|Methylococcales G Carbohydrate phosphorylase - - - - - - - - - - - - Phosphorylase k59_181387_1 768671.ThimaDRAFT_1574 3.91e-80 252.0 COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,1RPGZ@1236|Gammaproteobacteria,1WWD2@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_603562_1 756272.Plabr_1020 2.61e-42 156.0 COG1966@1|root,COG1966@2|Bacteria,2IWZE@203682|Planctomycetes 203682|Planctomycetes T Carbon starvation protein cstA - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM k59_1500224_1 1266925.JHVX01000007_gene2372 1.2e-31 119.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2VKP0@28216|Betaproteobacteria,372US@32003|Nitrosomonadales 28216|Betaproteobacteria S Protein of unknown function (DUF692) - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_1500224_3 1265503.KB905167_gene1712 1.96e-23 98.2 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,2Q5V6@267889|Colwelliaceae 1236|Gammaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_1127831_1 390989.JOEG01000006_gene889 5.87e-14 75.1 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - - - ko:K16648,ko:K20444 - - - - ko00000,ko01000,ko01003,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_tranf_2_3,Glycos_transf_2,Methyltransf_11,NTP_transf_5 k59_1386356_1 395493.BegalDRAFT_1120 6.77e-90 271.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,4603P@72273|Thiotrichales 72273|Thiotrichales E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_90824_1 1342301.JASD01000001_gene346 1.94e-67 212.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSMP@28211|Alphaproteobacteria,3ZXH5@60136|Sulfitobacter 28211|Alphaproteobacteria E ATPases associated with a variety of cellular activities - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_551043_1 331869.BAL199_24834 3.8e-80 255.0 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,4BPB8@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria CP Proton-conducting membrane transporter nuoN2 - 1.6.5.3 ko:K00343,ko:K05568 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 - - Proton_antipo_M k59_1021407_1 314285.KT71_05105 3.75e-25 94.0 COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,1SCEJ@1236|Gammaproteobacteria,1J6XH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL33 family rpmG GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 k59_1021407_2 1123399.AQVE01000006_gene3428 1.44e-32 114.0 COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,1S8UG@1236|Gammaproteobacteria,460X2@72273|Thiotrichales 72273|Thiotrichales J Belongs to the bacterial ribosomal protein bL28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k59_603577_1 526222.Desal_1855 6.51e-09 62.4 COG2204@1|root,COG2204@2|Bacteria,1NSFC@1224|Proteobacteria,42Y7Y@68525|delta/epsilon subdivisions,2WU6N@28221|Deltaproteobacteria,2M9NX@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - Sigma54_activat k59_90846_1 1121004.ATVC01000071_gene1165 9.22e-38 137.0 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2VJP9@28216|Betaproteobacteria,2KU4J@206351|Neisseriales 206351|Neisseriales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_710195_1 1145276.T479_04375 5.79e-10 65.5 COG0584@1|root,COG0584@2|Bacteria,1TQ3Y@1239|Firmicutes,4HAI9@91061|Bacilli,3IVP3@400634|Lysinibacillus 91061|Bacilli C phosphodiesterase - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_1500252_1 1415780.JPOG01000001_gene1772 1.79e-82 265.0 2DCM2@1|root,32TZV@2|Bacteria,1NAGE@1224|Proteobacteria,1SMRS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_603581_2 1305836.AXVE01000004_gene1338 1.43e-07 56.6 COG1372@1|root,COG1372@2|Bacteria,1UP4T@1239|Firmicutes,4HCZ5@91061|Bacilli 91061|Bacilli L LAGLIDADG-like domain - - - - - - - - - - - - LAGLIDADG_3 k59_344398_1 595460.RRSWK_04269 7.03e-59 199.0 COG3119@1|root,COG3119@2|Bacteria,2IXR4@203682|Planctomycetes 2|Bacteria P COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - Sulfatase k59_1444931_1 1312954.KI914852_gene670 2.55e-06 48.5 COG4108@1|root,COG4108@2|Bacteria,2GKQA@201174|Actinobacteria,1WB6R@1268|Micrococcaceae 201174|Actinobacteria J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,RF3_C k59_1444931_2 1344012.ATMI01000002_gene1525 3.16e-109 325.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,4BTNP@82986|Tatumella 1236|Gammaproteobacteria V AAA domain, putative AbiEii toxin, Type IV TA system yadG GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_396430_1 472759.Nhal_2694 3.06e-78 244.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,1WWM3@135613|Chromatiales 135613|Chromatiales S PFAM Alpha beta hydrolase - - - ko:K07019 - - - - ko00000 - - - Abhydrolase_1,Hydrolase_4 k59_292232_1 2880.D7G980 1.1e-60 200.0 COG0152@1|root,KOG2835@2759|Eukaryota 2759|Eukaryota F phosphoribosylaminoimidazole carboxylase activity - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009719,GO:0009725,GO:0009733,GO:0009987,GO:0010033,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_344409_1 706587.Desti_3607 1.29e-202 572.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2MR6S@213462|Syntrophobacterales 28221|Deltaproteobacteria E TIGRFAM glutamine synthetase, type I glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_1292748_1 883110.HMPREF9260_00994 2.95e-34 133.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HCVN@91061|Bacilli,27DPS@186827|Aerococcaceae 91061|Bacilli V ABC transporter, ATP-binding protein XK27_10035 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1292748_2 489825.LYNGBM3L_21190 9.12e-38 143.0 COG0438@1|root,COG0438@2|Bacteria,1GC2Y@1117|Cyanobacteria 1117|Cyanobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - k59_919229_1 1122165.AUHS01000026_gene1207 6.18e-144 421.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,1JCP3@118969|Legionellales 118969|Legionellales J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_865289_1 330214.NIDE2871 1.97e-105 322.0 COG2192@1|root,COG2192@2|Bacteria 2|Bacteria O nodulation nolO - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_396453_1 290398.Csal_1523 7.06e-34 125.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,1XJNP@135619|Oceanospirillales 135619|Oceanospirillales J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_137269_1 1479235.KK366039_gene1869 1.8e-62 204.0 COG2801@1|root,COG2801@2|Bacteria,1R6QN@1224|Proteobacteria,1S7GS@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - rve,rve_3 k59_292262_1 1123360.thalar_01998 5.59e-28 107.0 28I8Y@1|root,2Z8BR@2|Bacteria,1MXN1@1224|Proteobacteria,2TRAQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1638) - - - - - - - - - - - - DUF1638 k59_292262_2 1120956.JHZK01000010_gene2791 1.71e-74 229.0 COG5012@1|root,COG5012@2|Bacteria,1RDEU@1224|Proteobacteria,2TVXN@28211|Alphaproteobacteria,1JNIM@119043|Rhodobiaceae 28211|Alphaproteobacteria S B12 binding domain mtbC - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2 k59_1500302_1 755731.Clo1100_0799 1.15e-26 114.0 COG1251@1|root,COG1251@2|Bacteria,1TQYX@1239|Firmicutes,24AD5@186801|Clostridia,36WGG@31979|Clostridiaceae 186801|Clostridia C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_450154_1 1123368.AUIS01000028_gene1322 2.09e-36 134.0 COG2197@1|root,COG2197@2|Bacteria,1N8MU@1224|Proteobacteria,1S90D@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_1653547_1 1123376.AUIU01000014_gene552 5.72e-117 353.0 COG0296@1|root,COG0296@2|Bacteria,3J0WY@40117|Nitrospirae 40117|Nitrospirae G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_1292778_1 1493511.A0A0E3HIC2_9CAUD 2.45e-35 134.0 4QAZ6@10239|Viruses,4QPHV@28883|Caudovirales,4QI4H@10662|Myoviridae 10662|Myoviridae S Phage tail sheath protein - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098027 - - - - - - - - - - - k59_1292778_2 1493510.A0A0E3HJR8_9CAUD 2.53e-24 93.6 4QBDD@10239|Viruses,4QTX4@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1292778_3 268746.Q58MM6_BPPRM 2.14e-96 295.0 4QHDM@10239|Viruses,4QYV6@35237|dsDNA viruses no RNA stage,4QRD0@28883|Caudovirales,4QI2W@10662|Myoviridae 10662|Myoviridae S Terminase-like family - GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016032,GO:0016043,GO:0016787,GO:0016788,GO:0019058,GO:0019068,GO:0019069,GO:0019072,GO:0019075,GO:0022607,GO:0032991,GO:0034641,GO:0043170,GO:0043493,GO:0044085,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0046483,GO:0046797,GO:0051704,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0098009,GO:1901360,GO:1902494,GO:1904949 - - - - - - - - - - - k59_1536359_1 745014.OMB55_00006640 1.73e-108 331.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_760214_1 243231.GSU2758 7.75e-101 327.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_245637_1 1521187.JPIM01000063_gene2494 4.53e-61 201.0 COG2133@1|root,COG2133@2|Bacteria,2G62S@200795|Chloroflexi,375V8@32061|Chloroflexia 32061|Chloroflexia G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH k59_1181210_1 1411685.U062_00647 8.57e-80 263.0 COG1472@1|root,COG2730@1|root,COG1472@2|Bacteria,COG2730@2|Bacteria,1MVIV@1224|Proteobacteria,1RMA0@1236|Gammaproteobacteria,1J9ES@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G COG1472 Beta-glucosidase-related glycosidases - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Glyco_hydro_3,Glyco_hydro_3_C k59_1337432_1 522306.CAP2UW1_0384 2.95e-62 212.0 COG2885@1|root,COG3808@1|root,COG2885@2|Bacteria,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,1KQ7I@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_872197_1 1313172.YM304_32130 6.05e-68 222.0 COG1236@1|root,COG1236@2|Bacteria,2HEXB@201174|Actinobacteria 201174|Actinobacteria J Beta-lactamase - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL k59_99252_1 953739.SVEN_4233 1.76e-77 249.0 COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_99252_2 312153.Pnuc_0974 5.26e-20 84.3 COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,2VVNP@28216|Betaproteobacteria,1K8DM@119060|Burkholderiaceae 28216|Betaproteobacteria T Belongs to the BolA IbaG family bolA - - ko:K05527 - - - - ko00000,ko03000 - - - BolA k59_1028614_1 671143.DAMO_1656 1.24e-05 53.9 COG4591@1|root,COG4591@2|Bacteria,2NP18@2323|unclassified Bacteria 2|Bacteria M ABC-type transport system involved in lipoprotein release permease component lolC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778 - ko:K02004,ko:K09808 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.125 - - FtsX,MacB_PCD k59_517211_1 1382359.JIAL01000001_gene826 3.1e-62 209.0 COG0443@1|root,COG0443@2|Bacteria,3Y2F8@57723|Acidobacteria,2JIVF@204432|Acidobacteriia 204432|Acidobacteriia O heat shock protein 70 - - - ko:K04043,ko:K04044 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33,1.A.33.1 - - HSP70 k59_99255_1 756272.Plabr_1086 2.26e-33 126.0 COG0502@1|root,COG0502@2|Bacteria,2IXTG@203682|Planctomycetes 203682|Planctomycetes H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_403074_1 909663.KI867150_gene433 5.77e-143 423.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MQB7@213462|Syntrophobacterales 28221|Deltaproteobacteria O Belongs to the peptidase S1C family degP-2 - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_403074_2 236097.ADG881_2559 8.46e-42 151.0 COG4990@1|root,COG4990@2|Bacteria,1MVC4@1224|Proteobacteria,1RS1H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4872) - - - - - - - - - - - - BtrH_N,DUF4872 k59_676104_1 444860.E3SIV3_9CAUD 4.67e-33 116.0 4QGXP@10239|Viruses,4QYPM@35237|dsDNA viruses no RNA stage,4QRN0@28883|Caudovirales,4QIDG@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_352714_1 330214.NIDE0483 4.25e-90 275.0 COG4992@1|root,COG4992@2|Bacteria,3J0AB@40117|Nitrospirae 40117|Nitrospirae E Aminotransferase class-III argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1028638_1 1123367.C666_05030 2.92e-48 166.0 COG0348@1|root,COG0348@2|Bacteria,1MWR5@1224|Proteobacteria,2VJGG@28216|Betaproteobacteria,2KUBY@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S binding domain - - - ko:K02574 - - - - ko00000 - - - Fer4,Fer4_5 k59_717723_1 1229909.NSED_06105 2.41e-34 129.0 COG1793@1|root,arCOG01347@2157|Archaea,41SCK@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair lig - 6.5.1.1,6.5.1.6,6.5.1.7 ko:K10747 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N k59_1181247_1 1121033.AUCF01000005_gene5355 1.11e-34 135.0 COG4547@1|root,COG4547@2|Bacteria,1MX11@1224|Proteobacteria,2TS4N@28211|Alphaproteobacteria,2JQPT@204441|Rhodospirillales 204441|Rhodospirillales H COG4547 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide 5, 6-dimethylbenzimidazole phosphoribosyltransferase) cobT - 6.6.1.2 ko:K09883 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - CobT,CobT_C k59_1181247_2 1430440.MGMSRv2_4075 8.27e-14 70.1 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2TS1Z@28211|Alphaproteobacteria,2JPUC@204441|Rhodospirillales 204441|Rhodospirillales S Cobaltochelatase CobS subunit N terminal cobS - 6.6.1.2 ko:K09882 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - AAA_5,CobS_N k59_1392901_1 1313301.AUGC01000003_gene2067 5.7e-06 50.1 COG0593@1|root,COG0593@2|Bacteria,4NE6Q@976|Bacteroidetes 976|Bacteroidetes L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_1392901_2 1437882.AZRU01000022_gene6288 1.55e-16 79.7 COG1231@1|root,COG1231@2|Bacteria,1MUPQ@1224|Proteobacteria,1RZXR@1236|Gammaproteobacteria 1236|Gammaproteobacteria E amine oxidase pao - 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_188028_2 1463926.JOCA01000014_gene896 1.08e-12 71.2 COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria 201174|Actinobacteria HI Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_458028_1 159087.Daro_3360 4.07e-29 112.0 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2VM6F@28216|Betaproteobacteria,2KUQG@206389|Rhodocyclales 206389|Rhodocyclales T Serine/threonine phosphatases, family 2C, catalytic domain pppL - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 k59_458028_2 159087.Daro_3359 3.69e-18 81.3 COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,2VJ1K@28216|Betaproteobacteria,2KUV6@206389|Rhodocyclales 206389|Rhodocyclales T (FHA) domain - - - - - - - - - - - - FHA k59_1451415_1 247639.MGP2080_13508 1.09e-38 141.0 COG0625@1|root,COG0625@2|Bacteria,1P71B@1224|Proteobacteria,1RQZH@1236|Gammaproteobacteria,1J88N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0625 Glutathione S-transferase - - - - - - - - - - - - GST_C,GST_C_2,GST_N_3 k59_676186_1 1395571.TMS3_0117445 7.11e-55 191.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1664054_1 1121875.KB907547_gene3051 6.87e-09 60.1 COG4857@1|root,COG4857@2|Bacteria,4NHKI@976|Bacteroidetes,1I08V@117743|Flavobacteriia 976|Bacteroidetes S Phosphotransferase enzyme family mtnK - 2.7.1.100 ko:K00899 ko00270,ko01100,map00270,map01100 M00034 R04143 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APH k59_976273_1 105559.Nwat_0279 1.85e-35 128.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1WXGX@135613|Chromatiales 135613|Chromatiales E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_872271_1 441620.Mpop_1596 6.95e-51 179.0 COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,2TSVE@28211|Alphaproteobacteria,1JTSU@119045|Methylobacteriaceae 28211|Alphaproteobacteria C FAD binding domain - - 1.1.3.8,1.1.98.3 ko:K00103,ko:K16653 ko00053,ko01100,map00053,map01100 M00129 R00647,R03184,R10053 RC00195,RC00346,RC00869 ko00000,ko00001,ko00002,ko01000 - - - ALO,FAD_binding_4 k59_1028686_1 261292.Nit79A3_1360 7.8e-108 346.0 COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2WEJA@28216|Betaproteobacteria,374P7@32003|Nitrosomonadales 28216|Betaproteobacteria EO pdz dhr glgf - - - - - - - - - - - - PDZ_2,Peptidase_M1,Peptidase_M28 k59_1664072_1 1323663.AROI01000035_gene1402 1.06e-45 152.0 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria 1236|Gammaproteobacteria I oligoketide cyclase lipid transport protein ratA GO:0003674,GO:0005488,GO:0006417,GO:0006446,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044877,GO:0045947,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113 - - - - - - - - - - Polyketide_cyc k59_1181280_1 187272.Mlg_1981 6.41e-99 317.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1WVW8@135613|Chromatiales 135613|Chromatiales EF Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_1028692_2 948071.S4T7X9_9CAUD 1.76e-39 133.0 4QCEX@10239|Viruses,4QV7Q@35237|dsDNA viruses no RNA stage,4QU8B@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_517325_1 1260251.SPISAL_06810 9.33e-24 100.0 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,1WWW5@135613|Chromatiales 135613|Chromatiales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_517325_2 765911.Thivi_2316 1.94e-29 114.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1WWYB@135613|Chromatiales 135613|Chromatiales M Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_144938_1 316067.Geob_3632 1.11e-56 199.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,43T41@69541|Desulfuromonadales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_188060_1 762550.LEGAS_1873 6.04e-50 173.0 COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,4H9TQ@91061|Bacilli,4AXHH@81850|Leuconostocaceae 91061|Bacilli E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_144940_1 1166948.JPZL01000004_gene179 3.32e-106 315.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,1RR8F@1236|Gammaproteobacteria,1XRIQ@135619|Oceanospirillales 135619|Oceanospirillales L Integrase core domain - - - - - - - - - - - - HTH_21,rve_3 k59_676227_1 1469245.JFBG01000023_gene1254 5.07e-50 179.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales 135613|Chromatiales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1542970_1 1163617.SCD_n00358 2.42e-120 353.0 COG1277@1|root,COG1277@2|Bacteria,1MWUZ@1224|Proteobacteria,2VJDE@28216|Betaproteobacteria 28216|Betaproteobacteria S ABC-type transport system involved in multi-copper enzyme maturation permease component nosY - - ko:K01992,ko:K19341 ko02010,map02010 M00254,M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.132.2 - - ABC2_membrane_2 k59_188068_1 436308.Nmar_1072 4.13e-119 355.0 COG0028@1|root,arCOG01998@2157|Archaea,41S63@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM acetolactate synthase, large subunit, biosynthetic type - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_610161_1 765910.MARPU_07485 1.17e-52 176.0 COG2242@1|root,COG2242@2|Bacteria,1R79F@1224|Proteobacteria,1RY3Z@1236|Gammaproteobacteria,1WX5D@135613|Chromatiales 135613|Chromatiales H protein methyltransferase activity - - - - - - - - - - - - Methyltransf_25 k59_927745_1 429009.Adeg_1903 1.83e-16 87.0 COG5013@1|root,COG5013@2|Bacteria,1TQG1@1239|Firmicutes,25EID@186801|Clostridia,42HW2@68295|Thermoanaerobacterales 186801|Clostridia C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.7.5.1 ko:K00370,ko:K17050 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8 - - Molybdopterin,Molydop_binding k59_976307_1 1385521.N803_00820 2.14e-38 138.0 COG2353@1|root,COG2353@2|Bacteria,2GJUB@201174|Actinobacteria,4FF00@85021|Intrasporangiaceae 201174|Actinobacteria S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_1392940_2 519989.ECTPHS_07481 1.51e-114 342.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1WWNX@135613|Chromatiales 135613|Chromatiales E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_676242_1 1175306.GWL_14740 1.04e-09 59.3 COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VHZ2@28216|Betaproteobacteria,472VS@75682|Oxalobacteraceae 28216|Betaproteobacteria V Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K05685 ko02010,map02010 M00709 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.122.1,3.A.1.122.12 - - ABC_tran,FtsX,MacB_PCD k59_676242_2 330214.NIDE0349 1.39e-35 130.0 COG2755@1|root,COG2755@2|Bacteria 2|Bacteria E lipolytic protein G-D-S-L family tesA GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365 Lipase_GDSL_2 k59_517354_1 323261.Noc_2803 3.68e-38 138.0 COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,1WWHF@135613|Chromatiales 135613|Chromatiales EGP Major facilitator superfamily - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_517354_2 1266925.JHVX01000009_gene143 3.52e-18 83.2 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2VJA4@28216|Betaproteobacteria,37234@32003|Nitrosomonadales 28216|Betaproteobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_872305_1 1415778.JQMM01000001_gene1745 7.44e-65 220.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1J4IX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins ftsK GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1510799_1 351348.Maqu_2295 9.9e-05 44.7 COG2807@1|root,COG2807@2|Bacteria,1QUCZ@1224|Proteobacteria,1S32M@1236|Gammaproteobacteria,46AQQ@72275|Alteromonadaceae 1236|Gammaproteobacteria P Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1510799_2 1299327.I546_5435 8.38e-36 126.0 2DQ16@1|root,334AZ@2|Bacteria,2IMJY@201174|Actinobacteria,23A9M@1762|Mycobacteriaceae 201174|Actinobacteria S SpoIIAA-like - - - - - - - - - - - - SpoIIAA-like k59_1303268_1 589924.Ferp_1683 4.16e-55 191.0 COG0683@1|root,arCOG01020@2157|Archaea,2XVWV@28890|Euryarchaeota,245XV@183980|Archaeoglobi 183980|Archaeoglobi E Periplasmic binding protein domain - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_927752_1 1499967.BAYZ01000184_gene4591 1.22e-73 236.0 COG0638@1|root,COG0638@2|Bacteria,2NQFW@2323|unclassified Bacteria 2|Bacteria O Pup-ligase protein pafA GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 ko:K13571 - M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 - - - Pup_ligase k59_517362_1 1047013.AQSP01000126_gene2726 1.22e-98 303.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2NNR2@2323|unclassified Bacteria 2|Bacteria G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_1181310_1 436114.SYO3AOP1_1577 1.26e-44 161.0 COG4591@1|root,COG4591@2|Bacteria,2G3PU@200783|Aquificae 200783|Aquificae M lipoprotein releasing system, transmembrane protein, LolC E family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_1303278_2 289376.THEYE_A0881 2.12e-10 65.9 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity - - - - - - - - - - - - OEP k59_833408_1 926550.CLDAP_04830 2.91e-48 169.0 COG0473@1|root,COG0473@2|Bacteria,2G66J@200795|Chloroflexi 200795|Chloroflexi C PFAM isocitrate isopropylmalate dehydrogenase - - 1.1.1.87 ko:K05824 ko00300,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map01100,map01120,map01130,map01210,map01230 M00030,M00433 R01934,R01936,R04862 RC00084,RC00114,RC00626 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_1542996_1 378806.STAUR_5618 6.03e-77 243.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,2YXTZ@29|Myxococcales 28221|Deltaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1664140_1 472759.Nhal_0357 9.39e-135 392.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales 1236|Gammaproteobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_1512402_2 1123024.AUII01000035_gene1223 1.28e-30 120.0 COG2414@1|root,COG2414@2|Bacteria,2IF1J@201174|Actinobacteria 201174|Actinobacteria C Aldehyde ferredoxin oxidoreductase - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_611335_1 1286106.MPL1_07308 5.89e-115 354.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,45ZUH@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_1665784_1 1049564.TevJSym_am00450 8.98e-33 122.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1J4PD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1665784_2 1266925.JHVX01000004_gene1298 3.33e-42 151.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,371UM@32003|Nitrosomonadales 28216|Betaproteobacteria C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase odhL GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_301931_1 649638.Trad_0736 8.9e-26 105.0 COG0438@1|root,COG0438@2|Bacteria,1WJTX@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M PFAM Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_301931_2 1121033.AUCF01000004_gene4701 2.12e-35 134.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JQXF@204441|Rhodospirillales 204441|Rhodospirillales E COG0367 Asparagine synthase (glutamine-hydrolyzing) - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_146083_1 1219072.VHA01S_024_00240 5.17e-50 175.0 COG1396@1|root,COG1396@2|Bacteria,1R3Z8@1224|Proteobacteria,1RRMV@1236|Gammaproteobacteria,1XVVD@135623|Vibrionales 135623|Vibrionales K Protein of unknown function (DUF3612) - - - - - - - - - - - - DUF3612,HTH_3,Peptidase_M78 k59_364844_2 1249627.D779_3911 4.18e-182 518.0 COG0076@1|root,COG0076@2|Bacteria,1MX25@1224|Proteobacteria,1RNSQ@1236|Gammaproteobacteria,1WXI5@135613|Chromatiales 135613|Chromatiales E Belongs to the group II decarboxylase family - - 4.1.1.15 ko:K01580 ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940 M00027 R00261,R00489,R01682,R02466 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Pyridoxal_deC k59_1039573_1 522306.CAP2UW1_1857 3.54e-47 169.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,1KQJR@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P Transport of potassium into the cell kup - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_1039573_2 1219065.VPR01S_06_02170 5.59e-13 69.3 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,1RPM6@1236|Gammaproteobacteria,1XW3V@135623|Vibrionales 135623|Vibrionales P Transport of potassium into the cell kup GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_416377_1 765911.Thivi_3209 4.26e-102 310.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,1WW9T@135613|Chromatiales 135613|Chromatiales P PFAM Citrate transporter - - - - - - - - - - - - CitMHS k59_940212_1 445973.CLOBAR_01242 6.64e-22 95.5 COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,247Y5@186801|Clostridia,25QNU@186804|Peptostreptococcaceae 186801|Clostridia H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS thiI - 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07461 - ko00000,ko00001,ko01000,ko03016 - - - THUMP,ThiI k59_777776_1 270374.MELB17_21395 5.55e-40 144.0 COG0715@1|root,COG0715@2|Bacteria,1R5S6@1224|Proteobacteria,1RZSB@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1_2 k59_569667_1 1123322.KB904634_gene2366 3.61e-40 143.0 COG0412@1|root,COG0412@2|Bacteria 2|Bacteria Q carboxymethylenebutenolidase activity - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_364861_1 243233.MCA2375 6.92e-93 293.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1XDNZ@135618|Methylococcales 135618|Methylococcales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_623548_1 1101189.AQUO01000002_gene165 4.47e-11 64.7 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TV6K@28211|Alphaproteobacteria,2PVIQ@265|Paracoccus 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1096681_1 891968.Anamo_1755 3.31e-66 213.0 COG2513@1|root,COG2513@2|Bacteria,3T9VU@508458|Synergistetes 508458|Synergistetes G Phosphoenolpyruvate phosphomutase - - 4.1.3.32 ko:K20454 ko00760,ko01120,map00760,map01120 - R01355 RC00286,RC01810 ko00000,ko00001,ko01000 - - - PEP_mutase k59_256676_1 671143.DAMO_2489 1.41e-58 200.0 COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria 2|Bacteria NU Type II secretion system (T2SS), protein E, N-terminal domain xpsE GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_1039597_1 1434929.X946_1621 1.63e-45 152.0 COG3791@1|root,COG3791@2|Bacteria,1N6S5@1224|Proteobacteria,2VWNN@28216|Betaproteobacteria,1K87H@119060|Burkholderiaceae 28216|Betaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_416439_1 1122236.KB905144_gene2404 7.24e-15 75.1 COG5488@1|root,COG5488@2|Bacteria,1N5Z9@1224|Proteobacteria,2VU1W@28216|Betaproteobacteria,2KN5A@206350|Nitrosomonadales 206350|Nitrosomonadales S Integral membrane protein (DUF2244) - - - - - - - - - - - - DUF2244 k59_1193624_1 1123400.KB904748_gene312 3.22e-47 164.0 COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,1RP7K@1236|Gammaproteobacteria,4625M@72273|Thiotrichales 72273|Thiotrichales M Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division - - - ko:K08304 - - - - ko00000,ko01000,ko01011 - GH102 - 3D,MltA k59_256705_1 756272.Plabr_0265 3.54e-26 111.0 COG2211@1|root,COG2211@2|Bacteria,2IY9C@203682|Planctomycetes 203682|Planctomycetes G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1096734_1 1479239.JQMU01000001_gene834 7.31e-19 87.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria,2JZVP@204457|Sphingomonadales 204457|Sphingomonadales I acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1096734_2 1304275.C41B8_06032 3.75e-21 92.4 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C acyl-CoA transferases carnitine dehydratase - - - - - - - - - - - - CoA_transf_3 k59_728763_1 1123229.AUBC01000013_gene2654 1.01e-09 64.3 COG0697@1|root,COG0697@2|Bacteria,1RA23@1224|Proteobacteria,2U6RA@28211|Alphaproteobacteria,3K41U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_1039641_1 1007104.SUS17_2837 1.67e-09 53.9 2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2UG8Q@28211|Alphaproteobacteria,2K7CP@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_1039641_2 1187851.A33M_4071 3.25e-28 110.0 COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,2TU8X@28211|Alphaproteobacteria,3FE8I@34008|Rhodovulum 28211|Alphaproteobacteria K Cyclic nucleotide-monophosphate binding domain - - - ko:K01420,ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1349857_1 153721.MYP_3027 1.27e-80 268.0 COG1201@1|root,COG1201@2|Bacteria,4NGQ0@976|Bacteroidetes,47NAU@768503|Cytophagia 976|Bacteroidetes L DEAD DEAH box helicase lhr - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_987304_1 436308.Nmar_0064 3.36e-99 295.0 COG0648@1|root,arCOG01894@2157|Archaea,41SDW@651137|Thaumarchaeota 651137|Thaumarchaeota L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo - 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 k59_201599_1 448385.sce8249 6.59e-45 168.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2YYD8@29|Myxococcales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1349872_1 1121937.AUHJ01000010_gene1710 2.6e-38 135.0 COG4689@1|root,COG4689@2|Bacteria,1NSF0@1224|Proteobacteria,1RZ1E@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Acetoacetate decarboxylase - - - - - - - - - - - - ADC k59_987317_1 1122176.KB903536_gene1794 1.71e-11 69.7 COG1361@1|root,COG2356@1|root,COG3291@1|root,COG1361@2|Bacteria,COG2356@2|Bacteria,COG3291@2|Bacteria,4PM78@976|Bacteroidetes 976|Bacteroidetes M Conserved repeat domain - - - - - - - - - - - - CARDB k59_623692_1 999141.GME_07919 1.3e-36 134.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RM9E@1236|Gammaproteobacteria,1XIQM@135619|Oceanospirillales 135619|Oceanospirillales P Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system - - - - - - - - - - - - ABC_tran,TOBE_2 k59_623692_2 331869.BAL199_17938 6.85e-52 177.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,4BPQ9@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C C-terminal domain of alpha-glycerophosphate oxidase glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_1096775_3 335284.Pcryo_1451 7.76e-11 63.9 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1RGCV@1224|Proteobacteria,1SJP8@1236|Gammaproteobacteria,3NTQ6@468|Moraxellaceae 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF,PAS,PAS_9,Response_reg,dCache_1,dCache_3 k59_22861_1 543728.Vapar_4440 3.63e-09 63.5 COG0457@1|root,COG0457@2|Bacteria,1Q84V@1224|Proteobacteria,2VJAQ@28216|Betaproteobacteria,4AB2J@80864|Comamonadaceae 28216|Betaproteobacteria NU PFAM TPR repeat-containing protein - - - - - - - - - - - - DUF4440,TPR_11,TPR_16,TPR_17,TPR_19,TPR_8 k59_1405234_1 330214.NIDE1009 1.62e-83 258.0 COG2385@1|root,COG2385@2|Bacteria,3J15K@40117|Nitrospirae 40117|Nitrospirae D Stage II sporulation protein - - - ko:K06381 - - - - ko00000 - - - SpoIID k59_883287_1 553385.JEMF01000016_gene470 4.29e-39 144.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1XH8M@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_256753_1 1094508.Tsac_1834 3.75e-12 66.2 COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia,42F53@68295|Thermoanaerobacterales 186801|Clostridia J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_256753_2 1304885.AUEY01000003_gene541 1.66e-34 121.0 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,42TPZ@68525|delta/epsilon subdivisions,2WQ0P@28221|Deltaproteobacteria,2MKH5@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA rpsO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_1611355_1 493475.GARC_2930 4.11e-79 251.0 COG1228@1|root,COG1228@2|Bacteria,1RCA0@1224|Proteobacteria,1S08B@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1,CIA30 k59_1405256_1 296591.Bpro_5325 5.51e-13 68.2 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VMFC@28216|Betaproteobacteria,4AFKG@80864|Comamonadaceae 28216|Betaproteobacteria I Fatty acid desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_365005_1 1123487.KB892834_gene3070 2.83e-31 115.0 COG0671@1|root,COG0671@2|Bacteria,1QFZ7@1224|Proteobacteria 1224|Proteobacteria I PAP2 superfamily - - - - - - - - - - - - PAP2_3 k59_365005_2 382464.ABSI01000012_gene2146 1.82e-16 79.3 COG1593@1|root,COG1593@2|Bacteria 2|Bacteria G mannitol 2-dehydrogenase activity - - - ko:K11690 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctM,DctQ k59_313330_1 301.JNHE01000004_gene1682 9.15e-40 136.0 COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,1S3XB@1236|Gammaproteobacteria,1YD6T@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria F Nudix N-terminal - - - - - - - - - - - - NUDIX,Nudix_N_2 k59_1349934_2 991905.SL003B_2008 6.5e-62 197.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,4BPA2@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E ABC transporter glnQ - 3.6.3.21 ko:K02028,ko:K09972 ko02010,map02010 M00232,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - ABC_tran k59_1612935_1 1121921.KB898706_gene3090 2.15e-57 203.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RNWM@1236|Gammaproteobacteria,2PNAV@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_779803_1 1158345.JNLL01000001_gene749 5.42e-34 130.0 COG1721@1|root,COG1721@2|Bacteria,2G50A@200783|Aquificae 200783|Aquificae S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_885102_1 1229909.NSED_09745 6.36e-14 79.0 COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger k59_1407817_1 404589.Anae109_3692 0.000146 44.7 COG1664@1|root,COG1664@2|Bacteria,1RHS7@1224|Proteobacteria 1224|Proteobacteria M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_571940_2 911045.PSE_2508 2.87e-45 159.0 COG0665@1|root,COG0665@2|Bacteria,1MU7M@1224|Proteobacteria,2TT69@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0665 Glycine D-amino acid oxidases (deaminating) - - - - - - - - - - - - DAO k59_205079_1 794903.OPIT5_19995 9.15e-19 90.5 COG1629@1|root,COG4771@2|Bacteria,46U6D@74201|Verrucomicrobia,3K90V@414999|Opitutae 414999|Opitutae P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug,TonB_dep_Rec k59_205081_1 472759.Nhal_0508 8.01e-45 156.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1WW19@135613|Chromatiales 135613|Chromatiales J Responsible for synthesis of pseudouridine from uracil - - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1559635_1 1125863.JAFN01000001_gene622 7.16e-16 80.1 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,42M2D@68525|delta/epsilon subdivisions,2WJU6@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Lipopolysaccharide biosynthesis protein wzc1 - - - - - - - - - - - GNVR,Wzz k59_1559658_1 329726.AM1_2758 1.74e-26 103.0 COG0854@1|root,COG0854@2|Bacteria,1G0QW@1117|Cyanobacteria 1117|Cyanobacteria H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_1559658_2 882.DVU_1282 1.8e-29 117.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,42M6I@68525|delta/epsilon subdivisions,2WJTV@28221|Deltaproteobacteria,2M8BX@213115|Desulfovibrionales 28221|Deltaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - iAF987.Gmet_1886 PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1612994_1 68170.KL590489_gene10334 2.35e-09 63.5 COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria,4E68P@85010|Pseudonocardiales 201174|Actinobacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - 5.5.1.1 ko:K01856 ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220 M00568 R05300,R05390,R06989,R08116,R09229 RC00903,RC01038,RC01108,RC01321,RC01356 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_885153_1 471854.Dfer_3148 4.54e-50 183.0 COG2931@1|root,COG2931@2|Bacteria,4NKIR@976|Bacteroidetes,47S7V@768503|Cytophagia 976|Bacteroidetes Q SMART Integrin alpha beta-propellor repeat protein - - - - - - - - - - - - CHU_C,FG-GAP,HYR,VCBS k59_23814_1 1121935.AQXX01000060_gene1987 4.3e-21 89.4 COG4089@1|root,COG4089@2|Bacteria,1MV8K@1224|Proteobacteria,1S5RT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1614) - - - - - - - - - - - - DUF1614 k59_23814_3 330214.NIDE3826 5.76e-19 85.5 COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,3J0XX@40117|Nitrospirae 40117|Nitrospirae I CoA enzyme activase uncharacterised domain (DUF2229) - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_779887_1 1192034.CAP_2209 2.38e-57 196.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,42M94@68525|delta/epsilon subdivisions,2WINB@28221|Deltaproteobacteria,2YUHB@29|Myxococcales 28221|Deltaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_731001_1 661367.LLO_1764 7.44e-120 357.0 COG4651@1|root,COG4651@2|Bacteria,1QUQS@1224|Proteobacteria,1T21E@1236|Gammaproteobacteria,1JCA1@118969|Legionellales 118969|Legionellales P sodium hydrogen antiporter kefC_2 - - - - - - - - - - - Na_H_Exchanger k59_885168_2 1124983.PFLCHA0_c06830 1.02e-55 180.0 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,1S3PX@1236|Gammaproteobacteria,1YPGV@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0560 DHquinase_II k59_990904_2 1502852.FG94_04744 6.2e-14 71.6 COG5496@1|root,COG5496@2|Bacteria,1RKFT@1224|Proteobacteria,2VV65@28216|Betaproteobacteria,4756V@75682|Oxalobacteraceae 28216|Betaproteobacteria S Thioesterase - - 3.1.2.29 ko:K18700 - - - - ko00000,ko01000 - - - 4HBT k59_731013_1 316274.Haur_4652 1.41e-16 84.3 COG1404@1|root,COG1404@2|Bacteria,2G8UU@200795|Chloroflexi,3759F@32061|Chloroflexia 32061|Chloroflexia O PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Peptidase_S8 k59_1559724_1 1323663.AROI01000006_gene2841 1.66e-06 55.1 COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,1RNU3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Von willebrand factor, type a - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_1613018_1 580332.Slit_1835 3.74e-53 190.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,44VD6@713636|Nitrosomonadales 28216|Betaproteobacteria C 2-oxoglutarate dehydrogenase N-terminus sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_259008_1 247634.GPB2148_990 7.73e-140 414.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1407925_1 472759.Nhal_0505 4.82e-90 275.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1WX43@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_990976_1 1535422.ND16A_2889 1.55e-31 118.0 COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,1S40A@1236|Gammaproteobacteria,2Q74I@267889|Colwelliaceae 1236|Gammaproteobacteria S Bacterial protein of unknown function (DUF924) - - - - - - - - - - - - DUF924 k59_259021_1 1480694.DC28_04730 2.47e-07 59.3 COG2211@1|root,COG2211@2|Bacteria,2J6P4@203691|Spirochaetes 203691|Spirochaetes G transporter - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_577522_1 105559.Nwat_0472 2.01e-55 182.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1WXUC@135613|Chromatiales 135613|Chromatiales S ABC-type transport system involved in multi-copper enzyme maturation, permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 k59_525352_1 1232410.KI421424_gene1839 1.02e-83 264.0 COG0477@1|root,COG2814@2|Bacteria,1QUY6@1224|Proteobacteria,43DH9@68525|delta/epsilon subdivisions,2X8P2@28221|Deltaproteobacteria 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_525352_2 1121033.AUCF01000001_gene1961 1.61e-08 60.5 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria 28211|Alphaproteobacteria O COG0457 FOG TPR repeat - - - - - - - - - - - - Glyco_transf_41,TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8 k59_1047784_1 345219.Bcoa_1387 9.91e-25 113.0 COG0514@1|root,COG0514@2|Bacteria,1TPN5@1239|Firmicutes,4H9QP@91061|Bacilli,1ZC4U@1386|Bacillus 91061|Bacilli L DNA helicase recQ GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind k59_1516879_1 1283300.ATXB01000001_gene1582 5.21e-54 186.0 COG0852@1|root,COG3261@1|root,COG0852@2|Bacteria,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,1RSJ4@1236|Gammaproteobacteria,1XERA@135618|Methylococcales 135618|Methylococcales C Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - - - - - - - - - - Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases k59_316660_1 519989.ECTPHS_08231 4.27e-76 250.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_211986_1 314266.SKA58_06950 3.14e-48 167.0 COG3239@1|root,COG3239@2|Bacteria,1MVY5@1224|Proteobacteria,2U156@28211|Alphaproteobacteria,2K0CR@204457|Sphingomonadales 204457|Sphingomonadales I Fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_1047786_1 1283300.ATXB01000002_gene3171 1.43e-111 329.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1XEK1@135618|Methylococcales 135618|Methylococcales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_942996_1 697282.Mettu_0561 2.9e-82 254.0 28HK0@1|root,2Z7V0@2|Bacteria,1MXSJ@1224|Proteobacteria,1RRAP@1236|Gammaproteobacteria,1XG88@135618|Methylococcales 135618|Methylococcales S Domain of unknown function (DUF4105) - - - - - - - - - - - - DUF4105 k59_1361260_1 96561.Dole_0490 2.13e-16 86.3 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WKJV@28221|Deltaproteobacteria,2MHMF@213118|Desulfobacterales 28221|Deltaproteobacteria NU Tfp pilus assembly protein tip-associated adhesin pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,PA14 k59_264306_1 1234364.AMSF01000037_gene228 4.38e-18 83.6 2CM2H@1|root,32SDI@2|Bacteria,1NPEY@1224|Proteobacteria,1TH36@1236|Gammaproteobacteria,1XAW5@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_838878_1 316275.VSAL_I0442 4.07e-81 269.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1XSUY@135623|Vibrionales 135623|Vibrionales E COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_995170_1 1266925.JHVX01000003_gene591 5.86e-39 150.0 COG2857@1|root,COG2857@2|Bacteria,1QWB9@1224|Proteobacteria,2WGY5@28216|Betaproteobacteria,371Z2@32003|Nitrosomonadales 28216|Betaproteobacteria C Cytochrome c1 - - - - - - - - - - - - - k59_1257342_1 1121890.AUDO01000019_gene1053 2.26e-18 89.7 COG3829@1|root,COG4251@1|root,COG3829@2|Bacteria,COG4251@2|Bacteria,4NF1K@976|Bacteroidetes,1IINU@117743|Flavobacteriia,2P0EW@237|Flavobacterium 976|Bacteroidetes T Heme NO binding associated - - - - - - - - - - - - GAF_2,HATPase_c,HNOBA,HisKA,PAS_9 k59_1257342_2 1129794.C427_4367 5.48e-13 66.2 COG1060@1|root,COG1060@2|Bacteria,1N4ZG@1224|Proteobacteria,1SR1B@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Haem-NO-binding - - - - - - - - - - - - HNOB k59_1516891_1 768671.ThimaDRAFT_0726 8.5e-49 167.0 COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,1RXX2@1236|Gammaproteobacteria,1WX24@135613|Chromatiales 135613|Chromatiales S VWA-like domain (DUF2201) - - - - - - - - - - - - DUF2201,DUF2201_N k59_577547_1 227377.CBU_0811 1.85e-96 297.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1JC6Q@118969|Legionellales 118969|Legionellales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_1047803_1 338966.Ppro_2419 2.68e-10 65.5 COG4972@1|root,COG4972@2|Bacteria,1NUYA@1224|Proteobacteria,42ZJI@68525|delta/epsilon subdivisions,2WV3A@28221|Deltaproteobacteria,43UN3@69541|Desulfuromonadales 28221|Deltaproteobacteria NU Pilus assembly protein pulM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_316680_1 247490.KSU1_B0409 1.15e-90 272.0 COG0529@1|root,COG0529@2|Bacteria,2IYUQ@203682|Planctomycetes 203682|Planctomycetes F Catalyzes the synthesis of activated sulfate cysC GO:0000096,GO:0000103,GO:0003674,GO:0003824,GO:0004779,GO:0004781,GO:0006082,GO:0006520,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010134,GO:0016740,GO:0016772,GO:0016779,GO:0019379,GO:0019419,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0055114,GO:0070566,GO:0071704,GO:1901564 2.7.1.25 ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase k59_1152011_1 530564.Psta_1013 3.86e-26 105.0 COG1163@1|root,COG1163@2|Bacteria,2IWYP@203682|Planctomycetes 203682|Planctomycetes S TGS domain - - - ko:K06944 - - - - ko00000 - - - MMR_HSR1,TGS k59_1047810_1 105559.Nwat_3080 1.2e-95 296.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1WXE2@135613|Chromatiales 135613|Chromatiales EGP PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_107191_1 1201293.AKXQ01000023_gene4229 1.03e-131 384.0 COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate tdh GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006566,GO:0006567,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0008652,GO:0008743,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046870,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - iEC042_1314.EC042_3926,iECUMN_1333.ECUMN_4133,iPC815.YPO0060 ADH_N,ADH_zinc_N k59_56029_1 1121937.AUHJ01000008_gene2135 5.75e-60 200.0 2DBBP@1|root,2Z88Z@2|Bacteria,1R3B4@1224|Proteobacteria,1S25X@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_995186_1 1380394.JADL01000004_gene5741 1.04e-121 352.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2TSVS@28211|Alphaproteobacteria,2JQE0@204441|Rhodospirillales 204441|Rhodospirillales S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_212020_1 1134474.O59_002395 1.81e-11 70.1 COG1376@1|root,COG2931@1|root,COG4254@1|root,COG4932@1|root,COG1376@2|Bacteria,COG2931@2|Bacteria,COG4254@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1FGNW@10|Cellvibrio 1236|Gammaproteobacteria MQ Cadherin-like - - - - - - - - - - - - Cadherin,Cadherin_3,HemolysinCabind,PA14 k59_1622430_2 1265505.ATUG01000003_gene24 3.78e-33 127.0 COG0436@1|root,COG0436@2|Bacteria,1QW10@1224|Proteobacteria,42MQA@68525|delta/epsilon subdivisions,2WJDK@28221|Deltaproteobacteria,2MJ7D@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM aminotransferase class I and II bamJ - - - - - - - - - - - Aminotran_1_2 k59_212025_1 436308.Nmar_0500 2.61e-146 421.0 COG0126@1|root,arCOG00496@2157|Archaea,41SMB@651137|Thaumarchaeota 651137|Thaumarchaeota G Phosphoglycerate kinase pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_74114_1 765912.Thimo_3273 3.07e-15 74.7 COG0457@1|root,COG0457@2|Bacteria,1RESK@1224|Proteobacteria,1S41N@1236|Gammaproteobacteria,1WYBB@135613|Chromatiales 135613|Chromatiales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_2 k59_74114_2 986075.CathTA2_2854 1.34e-08 56.2 COG1038@1|root,COG1038@2|Bacteria,1UHP9@1239|Firmicutes,4IS56@91061|Bacilli 91061|Bacilli C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second pyc - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA k59_1320793_6 1123058.KB894230_gene1204 1.25e-46 155.0 COG3023@1|root,COG3023@2|Bacteria,4NQ2J@976|Bacteroidetes,1I3X8@117743|Flavobacteriia 976|Bacteroidetes V N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01447 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Amidase_2 k59_1275654_1 1480694.DC28_11625 1.01e-75 245.0 COG1166@1|root,COG1166@2|Bacteria,2J9X5@203691|Spirochaetes 203691|Spirochaetes H arginine decarboxylase speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_489977_1 1121878.AUGL01000021_gene2815 3.26e-131 390.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_697929_1 1341679.P253_00129 2.16e-29 110.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,1RMX1@1236|Gammaproteobacteria,3NIF3@468|Moraxellaceae 1236|Gammaproteobacteria E ABC transporter gltL GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.21 ko:K02028,ko:K02029,ko:K10004 ko02010,ko02020,map02010,map02020 M00230,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.19,3.A.1.3.4 - iAPECO1_1312.APECO1_1411,iE2348C_1286.E2348C_0545,iECOK1_1307.ECOK1_0655,iECP_1309.ECP_0675,iECS88_1305.ECS88_0687,iEcSMS35_1347.EcSMS35_0673,iUMN146_1321.UM146_14290,iUTI89_1310.UTI89_C0648 ABC_tran k59_697929_2 1380394.JADL01000002_gene1465 1.18e-64 204.0 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2TQZ7@28211|Alphaproteobacteria,2JWM5@204441|Rhodospirillales 204441|Rhodospirillales E Binding-protein-dependent transport system inner membrane component - - - ko:K10002 ko02010,ko02020,map02010,map02020 M00230 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.19,3.A.1.3.4 - - BPD_transp_1 k59_1221277_1 1026882.MAMP_01479 6.92e-48 169.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,45ZQH@72273|Thiotrichales 72273|Thiotrichales E peptidase - - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_1221277_2 396588.Tgr7_2532 6.55e-06 49.7 COG2433@1|root,COG2433@2|Bacteria,1QWB7@1224|Proteobacteria,1T3FV@1236|Gammaproteobacteria,1X2R3@135613|Chromatiales 135613|Chromatiales S Bacterial SH3 domain homologues - - - ko:K07184 - - - - ko00000 - - - SH3_3 k59_384560_1 948106.AWZT01000002_gene6156 2.53e-36 142.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria,1K0RI@119060|Burkholderiaceae 28216|Betaproteobacteria F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_384560_2 1134474.O59_003259 1.66e-60 197.0 COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,1S2TG@1236|Gammaproteobacteria,1FGKC@10|Cellvibrio 1236|Gammaproteobacteria S Beta-lactamase superfamily domain yycJ - - - - - - - - - - - Lactamase_B_2 k59_489984_2 713587.THITH_04330 6.55e-11 64.3 COG0789@1|root,COG0789@2|Bacteria,1R9SN@1224|Proteobacteria,1S967@1236|Gammaproteobacteria,1WYBA@135613|Chromatiales 135613|Chromatiales K helix_turn_helix, mercury resistance - - - ko:K22491 - - - - ko00000,ko03000 - - - MerR_1 k59_538989_1 566466.NOR53_590 6.93e-82 270.0 COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,1RZK1@1236|Gammaproteobacteria,1J7X0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 k59_74134_1 589924.Ferp_1065 0.000424 47.8 COG3979@1|root,arCOG02537@1|root,arCOG02537@2157|Archaea,arCOG07581@2157|Archaea 2157|Archaea C PKD domain containing protein - - - - - - - - - - - - PKD k59_852879_1 1120970.AUBZ01000003_gene149 1.85e-13 69.7 COG0220@1|root,COG0220@2|Bacteria,1RE0G@1224|Proteobacteria,1RS5R@1236|Gammaproteobacteria,466IB@72275|Alteromonadaceae 1236|Gammaproteobacteria J Putative methyltransferase - - - - - - - - - - - - Methyltransf_4 k59_1583738_1 1229909.NSED_02125 1.43e-47 162.0 COG0517@1|root,arCOG00601@2157|Archaea 2157|Archaea C CBS domain - - - - - - - - - - - - - k59_1320801_1 639282.DEFDS_0397 4.98e-11 68.2 COG1287@1|root,COG1287@2|Bacteria,2GEIR@200930|Deferribacteres 200930|Deferribacteres S oligosaccharyl transferase activity - - 2.4.99.18 ko:K07151 ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141 M00072 R04216,R05976 RC00005,RC00482 ko00000,ko00001,ko00002,ko01000,ko01003 - GT66 - STT3 k59_122330_1 998674.ATTE01000001_gene3483 2.03e-13 70.1 COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S953@1236|Gammaproteobacteria,4611G@72273|Thiotrichales 72273|Thiotrichales S Protein of unknown function, DUF484 - - - ko:K09921 - - - - ko00000 - - - DUF484 k59_122330_2 1384054.N790_06705 1.31e-26 107.0 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1X31C@135614|Xanthomonadales 135614|Xanthomonadales L Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_1583739_1 861299.J421_0093 1.74e-06 54.7 COG4257@1|root,COG4257@2|Bacteria,1ZUIM@142182|Gemmatimonadetes 142182|Gemmatimonadetes V antibiotic catabolic process - - - ko:K18235 - - - - ko00000,ko01000,ko01504 - - - - k59_1009161_1 1229205.BUPH_03869 1.01e-91 280.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2VHDY@28216|Betaproteobacteria,1K3NA@119060|Burkholderiaceae 28216|Betaproteobacteria C NADH flavin oxidoreductase NADH oxidase namA - 1.14.13.40,1.3.1.34 ko:K00219,ko:K09461 ko00627,ko01120,map00627,map01120 - R03998,R03999 RC00244 ko00000,ko00001,ko01000 - - - Oxidored_FMN k59_489994_1 471857.Svir_29050 4.23e-19 79.0 COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria,4E6UD@85010|Pseudonocardiales 201174|Actinobacteria K PFAM 'Cold-shock' DNA-binding domain - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_956643_3 797304.Natgr_2810 4.96e-38 142.0 COG0516@1|root,arCOG00612@2157|Archaea,2XUCE@28890|Euryarchaeota,23TVE@183963|Halobacteria 183963|Halobacteria F IMP dehydrogenase GMP reductase guaB2 - 1.1.1.205,1.7.1.7 ko:K00088,ko:K00364 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R01134,R08240 RC00143,RC00457,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - IMPDH k59_331082_1 1396141.BATP01000023_gene509 2.46e-07 53.1 COG0500@1|root,COG0500@2|Bacteria,46YTR@74201|Verrucomicrobia,2IU3A@203494|Verrucomicrobiae 203494|Verrucomicrobiae Q methyltransferase - - - - - - - - - - - - Methyltransf_23,Response_reg k59_852890_1 1267005.KB911255_gene2707 7.07e-05 51.2 COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,1PJRR@1224|Proteobacteria,2U625@28211|Alphaproteobacteria 28211|Alphaproteobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - DUF4189,PG_binding_1,Pkinase,WD40 k59_697944_1 1231185.BAMP01000004_gene3825 1.24e-14 73.2 COG1014@1|root,COG1014@2|Bacteria,1MV7Q@1224|Proteobacteria,2TTHE@28211|Alphaproteobacteria,43H1P@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C Involved in the incorporation of exogenous aryl acids in the biosynthesis of aromatic amino acids catalysis of the ferredoxin-dependent oxidative decarboxylation of arylpyruvates - - 1.2.7.8 ko:K00180 - - - - br01601,ko00000,ko01000 - - - POR k59_697944_2 1231391.AMZF01000010_gene1702 2.84e-46 166.0 COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VK1K@28216|Betaproteobacteria,3T1XW@506|Alcaligenaceae 28216|Betaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding - - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - TPP_enzyme_C k59_1114177_2 984262.SGRA_0201 2.79e-28 109.0 COG0020@1|root,COG0020@2|Bacteria,4NF2B@976|Bacteroidetes,1IPRJ@117747|Sphingobacteriia 976|Bacteroidetes I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_1429843_1 298386.PBPRB0645 3.33e-57 194.0 COG0348@1|root,COG0348@2|Bacteria,1N605@1224|Proteobacteria 1224|Proteobacteria C COG0348 Polyferredoxin vnfA - - - - - - - - - - - Fer4_5 k59_384587_1 1434929.X946_1154 4.92e-29 117.0 COG0665@1|root,COG4121@1|root,COG0665@2|Bacteria,COG4121@2|Bacteria,1MZW5@1224|Proteobacteria,2VHGY@28216|Betaproteobacteria,1K1MC@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 mnmC - 2.1.1.61 ko:K15461 - - R00601,R08702 RC00003,RC00053,RC00060,RC01483 ko00000,ko01000,ko03016 - - - DAO,Methyltransf_30 k59_384587_2 1121406.JAEX01000015_gene586 3.17e-08 55.8 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2M7U6@213115|Desulfovibrionales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K01338,ko:K04076,ko:K04770 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Lon_C k59_1483558_3 1270193.JARP01000006_gene1776 8.91e-13 65.9 COG1335@1|root,COG1335@2|Bacteria,4NMQE@976|Bacteroidetes,1I2GJ@117743|Flavobacteriia,2NWK0@237|Flavobacterium 976|Bacteroidetes Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_1275708_1 768710.DesyoDRAFT_0806 1.76e-12 68.6 COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,26079@186807|Peptococcaceae 186801|Clostridia E TIGRFAM peptidase T-like protein - - 3.4.11.4 ko:K01258 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_852905_1 1304885.AUEY01000029_gene2512 5.35e-13 68.9 COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,42R2J@68525|delta/epsilon subdivisions,2WIJ6@28221|Deltaproteobacteria,2MIMF@213118|Desulfobacterales 28221|Deltaproteobacteria J PFAM ribosomal RNA methyltransferase RrmJ FtsJ tlyA - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k59_852905_2 498761.HM1_0295 2.07e-69 231.0 COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia 186801|Clostridia H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_544685_1 747365.Thena_1036 6.52e-126 393.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,42EYT@68295|Thermoanaerobacterales 186801|Clostridia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family nolG2 - - - - - - - - - - - ACR_tran k59_1168903_1 1187851.A33M_0656 3.39e-24 98.2 COG3382@1|root,COG3382@2|Bacteria,1N6A7@1224|Proteobacteria,2UJ4A@28211|Alphaproteobacteria 28211|Alphaproteobacteria S B3/4 domain - - - - - - - - - - - - B3_4 k59_1168903_2 1111479.AXAR01000020_gene1219 4.59e-54 180.0 COG1960@1|root,COG1960@2|Bacteria,1UK89@1239|Firmicutes,4HAR5@91061|Bacilli,279JU@186823|Alicyclobacillaceae 91061|Bacilli C Acyl-CoA dehydrogenase, N-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_442146_1 983548.Krodi_2522 7.46e-35 129.0 COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes,1HYK6@117743|Flavobacteriia,37EHB@326319|Dokdonia 976|Bacteroidetes M Glycine zipper yiaD - - - - - - - - - - - Gly-zipper_Omp,OmpA k59_1228455_1 395495.Lcho_4131 1.26e-34 124.0 COG3245@1|root,COG3245@2|Bacteria,1RG2V@1224|Proteobacteria,2VS0Q@28216|Betaproteobacteria,1KNH3@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - Cytochrome_C7 k59_1228456_1 335543.Sfum_1609 7.54e-59 198.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MQAN@213462|Syntrophobacterales 28221|Deltaproteobacteria J TIGRFAM ribonuclease, Rne Rng family cafA - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_813996_1 765914.ThisiDRAFT_1141 4.69e-166 478.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_1228460_1 1121106.JQKB01000032_gene4434 1.27e-97 307.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQ9H@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_499284_1 1417296.U879_04755 7.78e-22 97.8 COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2TTX8@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG1960 Acyl-CoA dehydrogenases - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_859892_1 330214.NIDE4178 8.11e-113 330.0 COG1262@1|root,COG1262@2|Bacteria 2|Bacteria T PFAM Formylglycine-generating sulfatase enzyme - - - - - - - - - - - - FGE-sulfatase k59_285535_1 1123023.JIAI01000001_gene7505 1.34e-07 55.5 COG0010@1|root,COG0010@2|Bacteria 2|Bacteria E hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines - - 3.5.3.1,3.5.3.11 ko:K01476,ko:K01480 ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146 M00029,M00133,M00134 R00551,R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_912328_1 1121937.AUHJ01000010_gene1608 1.32e-59 196.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,4654G@72275|Alteromonadaceae 1236|Gammaproteobacteria H Involved in the biosynthesis of porphyrin-containing compound yggW GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_1285148_1 1042377.AFPJ01000043_gene953 4.47e-71 225.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,464RG@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050570,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_0056 PdxA k59_1016168_1 1205680.CAKO01000038_gene1637 4.71e-97 294.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TU1G@28211|Alphaproteobacteria,2JPQP@204441|Rhodospirillales 204441|Rhodospirillales C Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_1285155_1 1121374.KB891575_gene1260 8.55e-30 117.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_1285155_2 285514.JNWO01000035_gene7322 2.84e-20 88.2 COG3467@1|root,COG3467@2|Bacteria,2GJ76@201174|Actinobacteria 201174|Actinobacteria J Flavin-nucleotide-binding protein - - - ko:K07005 - - - - ko00000 - - - Pyridox_ox_2 k59_11150_1 398767.Glov_3496 9.15e-77 239.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,42N3Z@68525|delta/epsilon subdivisions,2WIPM@28221|Deltaproteobacteria,43TJM@69541|Desulfuromonadales 28221|Deltaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_11150_2 887898.HMPREF0551_1185 1.07e-05 46.6 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2VICH@28216|Betaproteobacteria,1K0BX@119060|Burkholderiaceae 28216|Betaproteobacteria F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_859910_1 1123368.AUIS01000011_gene1190 2.14e-36 134.0 COG0842@1|root,COG0842@2|Bacteria,1N55T@1224|Proteobacteria,1S29T@1236|Gammaproteobacteria,2NCSV@225057|Acidithiobacillales 225057|Acidithiobacillales V ABC-2 type transporter - - - ko:K09694 ko02010,map02010 M00252 - - ko00000,ko00001,ko00002,ko02000 3.A.1.102 - - ABC2_membrane k59_1120959_2 375286.mma_1958 1.33e-14 73.6 COG1463@1|root,COG1463@2|Bacteria,1R565@1224|Proteobacteria,2VK63@28216|Betaproteobacteria,473VY@75682|Oxalobacteraceae 28216|Betaproteobacteria Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_1229598_2 1297865.APJD01000008_gene5593 1.19e-19 92.0 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3JTUH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain cckA - 2.7.13.3 ko:K13587 ko02020,ko04112,map02020,map04112 M00512 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg k59_1438988_1 1449126.JQKL01000048_gene2663 3.49e-19 95.9 COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia,268GR@186813|unclassified Clostridiales 186801|Clostridia L ATP-dependent helicase nuclease subunit A - - 3.6.4.12 ko:K16898 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_1016190_1 1304878.AUGD01000040_gene3272 2.17e-37 130.0 COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria,3JZI8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_1016190_2 504472.Slin_2662 1.6e-84 261.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,4NJ32@976|Bacteroidetes,47TE9@768503|Cytophagia 976|Bacteroidetes L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_32,rve,rve_3 k59_754952_1 338963.Pcar_0023 2.25e-22 103.0 COG1199@1|root,COG2003@1|root,COG1199@2|Bacteria,COG2003@2|Bacteria,1MVCU@1224|Proteobacteria,42N57@68525|delta/epsilon subdivisions,2WJ82@28221|Deltaproteobacteria,43RYW@69541|Desulfuromonadales 28221|Deltaproteobacteria L HELICc2 dinG - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,RadC,ResIII k59_1326041_1 1123237.Salmuc_00331 3.72e-91 281.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG4584 Transposase and inactivated derivatives istA - - - - - - - - - - - rve k59_232595_1 392499.Swit_3641 3.11e-45 159.0 COG5361@1|root,COG5361@2|Bacteria,1PF7H@1224|Proteobacteria,2U4QR@28211|Alphaproteobacteria,2K2I1@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF1214) - - - - - - - - - - - - DUF1214 k59_815224_1 1192034.CAP_2864 5.71e-18 82.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42NBA@68525|delta/epsilon subdivisions,2X5CP@28221|Deltaproteobacteria 28221|Deltaproteobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_815224_2 1038859.AXAU01000003_gene6187 1.07e-59 202.0 COG0845@1|root,COG3409@1|root,COG0845@2|Bacteria,COG3409@2|Bacteria 2|Bacteria M Peptidoglycan-binding domain 1 protein - - 3.2.1.35 ko:K01197,ko:K02022 ko00531,ko01100,map00531,map01100 M00076,M00077 R07824,R07825,R10905 - ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042 - - - Biotin_lipoyl_2,HlyD_3,PG_binding_1,YkuD k59_1069092_1 1123073.KB899242_gene1358 8.78e-53 176.0 COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,1RP85@1236|Gammaproteobacteria,1X52R@135614|Xanthomonadales 135614|Xanthomonadales I enoyl-CoA hydratase - - 4.2.1.18 ko:K13766 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1645988_1 1042375.AFPL01000043_gene1400 7.32e-38 135.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,464DZ@72275|Alteromonadaceae 1236|Gammaproteobacteria D COG1192 ATPases involved in chromosome partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1645988_2 396588.Tgr7_3313 1.33e-33 125.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1WWNZ@135613|Chromatiales 135613|Chromatiales K Belongs to the ParB family - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_1285210_1 1122602.ATXP01000001_gene907 7.02e-07 48.5 COG0255@1|root,COG0255@2|Bacteria,2IQ6V@201174|Actinobacteria,1W9RW@1268|Micrococcaceae 201174|Actinobacteria J Belongs to the universal ribosomal protein uL29 family rpmC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_1285210_2 443254.Marpi_0871 3.73e-22 89.4 COG0186@1|root,COG0186@2|Bacteria,2GD97@200918|Thermotogae 200918|Thermotogae J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_1285210_4 215803.DB30_6152 1.16e-48 162.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,42QS6@68525|delta/epsilon subdivisions,2WMPD@28221|Deltaproteobacteria,2YURE@29|Myxococcales 28221|Deltaproteobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_391562_1 436308.Nmar_0308 8.8e-20 81.6 COG2146@1|root,arCOG02852@2157|Archaea,41SSE@651137|Thaumarchaeota 651137|Thaumarchaeota P Rieske 2Fe-2S - - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske k59_391562_2 1229909.NSED_01490 4.72e-63 202.0 COG0454@1|root,arCOG00845@2157|Archaea,41T5Q@651137|Thaumarchaeota 651137|Thaumarchaeota K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 k59_176701_1 1232410.KI421425_gene1545 3.63e-08 52.8 COG0848@1|root,COG0848@2|Bacteria,1N8FU@1224|Proteobacteria,42WU3@68525|delta/epsilon subdivisions,2WSMD@28221|Deltaproteobacteria,43UYT@69541|Desulfuromonadales 28221|Deltaproteobacteria U Biopolymer transport protein ExbD/TolR - - - - - - - - - - - - ExbD k59_1285219_1 1229909.NSED_00025 1.02e-52 175.0 COG1467@1|root,arCOG04110@2157|Archaea,41SCB@651137|Thaumarchaeota 651137|Thaumarchaeota L Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair priS - - ko:K02683 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DNA_primase_S k59_1531514_1 570952.ATVH01000005_gene1152 5.15e-12 67.4 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2JPCQ@204441|Rhodospirillales 28211|Alphaproteobacteria P COG2217 Cation transport ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_815252_1 316274.Haur_2046 1.05e-67 218.0 COG0517@1|root,COG0517@2|Bacteria 2|Bacteria S IMP dehydrogenase activity - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_83434_1 1112212.JH584235_gene3512 1.2e-06 59.3 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,2K1TQ@204457|Sphingomonadales 204457|Sphingomonadales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_83434_2 5679.XP_010697230.1 9.2e-16 89.0 COG0749@1|root,KOG0950@2759|Eukaryota,3XTEJ@5653|Kinetoplastida 5653|Kinetoplastida L mitochondrial DNA polymerase I protein D - - - - - - - - - - - - DNA_pol_A,DNA_pol_A_exo1 k59_1492824_1 572480.Arnit_0209 5.84e-35 130.0 COG3769@1|root,COG3769@2|Bacteria,1NFV5@1224|Proteobacteria,42SQA@68525|delta/epsilon subdivisions 1224|Proteobacteria S HAD-superfamily hydrolase, subfamily IIB yedP - 2.7.1.31,3.1.3.70 ko:K07026,ko:K15918 ko00051,ko00260,ko00561,ko00630,ko01100,ko01110,ko01130,ko01200,map00051,map00260,map00561,map00630,map01100,map01110,map01130,map01200 M00532 R01514,R05790 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Hydrolase_3,S6PP k59_1646020_1 1469245.JFBG01000016_gene959 4.99e-97 291.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,1WWRE@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes rpoH - - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_754990_2 1237149.C900_02493 4.37e-102 315.0 COG4409@1|root,COG4409@2|Bacteria,4NI5M@976|Bacteroidetes,47JYZ@768503|Cytophagia 976|Bacteroidetes G exo-alpha-(2->6)-sialidase activity - - - - - - - - - - - - BNR_2 k59_754990_3 1131553.JIBI01000026_gene58 2.76e-41 144.0 COG0500@1|root,COG2226@2|Bacteria,1PE85@1224|Proteobacteria,2W92M@28216|Betaproteobacteria,373FB@32003|Nitrosomonadales 28216|Betaproteobacteria Q Mycolic acid cyclopropane synthetase - - - - - - - - - - - - Methyltransf_25 k59_704835_1 323848.Nmul_A1038 4.52e-43 148.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHZW@28216|Betaproteobacteria,372AQ@32003|Nitrosomonadales 28216|Betaproteobacteria O prohibitin homologues - - - - - - - - - - - - Band_7 k59_704835_2 765912.Thimo_3322 4.39e-89 279.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria,1WXRD@135613|Chromatiales 135613|Chromatiales O NfeD-like C-terminal, partner-binding - - - ko:K07403 - - - - ko00000 - - - NfeD k59_499404_1 1169161.KB897723_gene4635 1.59e-49 180.0 2DBGS@1|root,2Z95N@2|Bacteria,2ICPX@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1646027_2 1163409.UUA_15778 4.95e-55 183.0 COG0463@1|root,COG0463@2|Bacteria,1MXC1@1224|Proteobacteria,1RRHP@1236|Gammaproteobacteria,1X33S@135614|Xanthomonadales 135614|Xanthomonadales M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_598457_1 1122194.AUHU01000004_gene1617 4.19e-27 114.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,466AG@72275|Alteromonadaceae 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9 k59_598457_2 1454004.AW11_01230 1.44e-13 71.2 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria 28216|Betaproteobacteria T metal-dependent phosphohydrolase, HD sub domain - - - ko:K07814,ko:K13815 ko02020,ko02024,map02020,map02024 M00517 - - ko00000,ko00001,ko00002,ko02022 - - - HD,HD_5,Response_reg k59_1492847_1 754477.Q7C_160 2.74e-34 129.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,45ZS4@72273|Thiotrichales 72273|Thiotrichales S Succinylglutamate desuccinylase aspartoacylase - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_443353_1 1209984.BN978_00918 3.29e-22 100.0 COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria,2370G@1762|Mycobacteriaceae 201174|Actinobacteria S amidohydrolase - - - - - - - - - - - - Amidohydro_3 k59_130610_1 1504981.KO116_2283 9.01e-29 117.0 COG0477@1|root,COG2814@2|Bacteria,1R02E@1224|Proteobacteria 1224|Proteobacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_545650_1 436308.Nmar_0471 6.04e-77 251.0 COG1948@1|root,arCOG02284@2157|Archaea,41T0R@651137|Thaumarchaeota 651137|Thaumarchaeota L Beta propeller domain - - - - - - - - - - - - Beta_propel k59_963479_2 1265313.HRUBRA_00256 2.84e-29 117.0 COG1711@1|root,COG1711@2|Bacteria,1RIA0@1224|Proteobacteria,1S715@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3014) - - - - - - - - - - - - DUF3014 k59_1531541_1 985665.HPL003_03470 5.08e-90 275.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,4H9YB@91061|Bacilli,26QEH@186822|Paenibacillaceae 91061|Bacilli P Belongs to the ABC transporter superfamily - - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_815312_2 83406.HDN1F_19680 1.39e-44 158.0 COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,1J56U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the acetyltransferase family. ArgA subfamily argA GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_2830,iLF82_1304.LF82_0116,iNRG857_1313.NRG857_13920,iYL1228.KPN_03226 AA_kinase,Acetyltransf_1 k59_443379_2 1121127.JAFA01000007_gene5162 1.15e-20 97.1 COG1960@1|root,COG1960@2|Bacteria,1NCCF@1224|Proteobacteria,2VTAD@28216|Betaproteobacteria,1K4F4@119060|Burkholderiaceae 28216|Betaproteobacteria C acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_704859_2 384765.SIAM614_14770 2.87e-61 195.0 COG3427@1|root,COG3427@2|Bacteria,1RHUC@1224|Proteobacteria,2U9HD@28211|Alphaproteobacteria 28211|Alphaproteobacteria S carbon monoxide dehydrogenase coxG - - ko:K09386 - - - - ko00000 - - - COXG k59_285656_1 224911.27355304 3.3e-08 59.3 COG1309@1|root,COG1309@2|Bacteria,1QTG5@1224|Proteobacteria,2U294@28211|Alphaproteobacteria,3JWM0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - TetR_C_7,TetR_N k59_130640_1 414684.RC1_0800 1.62e-50 177.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,2TU50@28211|Alphaproteobacteria,2JSBB@204441|Rhodospirillales 204441|Rhodospirillales U MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_912439_1 1110697.NCAST_26_01430 2.05e-31 124.0 COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria,4FVES@85025|Nocardiaceae 201174|Actinobacteria T phosphatase - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - Y_phosphatase3 k59_391607_2 1294143.H681_04485 4.62e-11 62.4 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_499448_1 425104.Ssed_2492 7.63e-41 154.0 COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,1RNU3@1236|Gammaproteobacteria,2QAT1@267890|Shewanellaceae 1236|Gammaproteobacteria S PFAM von Willebrand factor type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_912442_1 1166130.H650_14535 4.71e-73 223.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,3X1R0@547|Enterobacter 1236|Gammaproteobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0051259,GO:0051260,GO:0055086,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_912442_2 1454004.AW11_01205 3.1e-18 84.3 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2VJ29@28216|Betaproteobacteria,1KPVU@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III algC GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_668692_1 1415778.JQMM01000001_gene1407 2.83e-28 119.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1J4E5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Cation transporter/ATPase, N-terminus ctpF - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_1503166_1 1123073.KB899242_gene1226 5.3e-05 45.4 COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,1X4N7@135614|Xanthomonadales 135614|Xanthomonadales O Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmB - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB k59_1503166_2 686340.Metal_1019 5.09e-54 176.0 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,1RP3R@1236|Gammaproteobacteria,1XDXU@135618|Methylococcales 135618|Methylococcales U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm k59_668706_1 572477.Alvin_0947 5.56e-06 50.1 2DS56@1|root,33EJS@2|Bacteria,1NQ3F@1224|Proteobacteria,1SI4P@1236|Gammaproteobacteria,1WZU9@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_15077_1 28444.JODQ01000007_gene5269 3.89e-112 333.0 COG0596@1|root,COG0596@2|Bacteria,2GK79@201174|Actinobacteria,4EGQ4@85012|Streptosporangiales 201174|Actinobacteria S Epoxide hydrolase N terminus - - - - - - - - - - - - EHN k59_346795_2 876044.IMCC3088_716 5.41e-42 145.0 COG3101@1|root,COG3101@2|Bacteria,1NUZ3@1224|Proteobacteria,1SNKF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Elongation factor P hydroxylase - - - ko:K09906 - - - - ko00000,ko01000,ko03012 - - - EpmC k59_1597751_1 298655.KI912267_gene7641 3.68e-74 231.0 COG1024@1|root,COG1024@2|Bacteria,2HG10@201174|Actinobacteria,4EW6A@85013|Frankiales 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_1597751_2 331869.BAL199_22497 6.3e-28 108.0 COG1024@1|root,COG1024@2|Bacteria,1MWF6@1224|Proteobacteria,2TTQ1@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase MA20_19270 - - - - - - - - - - - ECH_1 k59_1332833_1 1229909.NSED_08790 2.78e-32 115.0 COG2238@1|root,arCOG01344@2157|Archaea,41SK1@651137|Thaumarchaeota 651137|Thaumarchaeota J May be involved in maturation of the 30S ribosomal subunit rps19e - - ko:K02966 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19e k59_1332833_2 1229909.NSED_08785 5.26e-37 128.0 COG2118@1|root,arCOG04179@2157|Archaea,41SR0@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the PDCD5 family - - - ko:K06875 - - - - ko00000 - - - dsDNA_bind k59_1176620_1 1056512.D515_00659 2.79e-06 54.7 COG0845@1|root,COG0845@2|Bacteria,1R67N@1224|Proteobacteria,1RYPZ@1236|Gammaproteobacteria,1XST6@135623|Vibrionales 135623|Vibrionales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - - k59_668718_2 138119.DSY3234 2.36e-28 115.0 COG4865@1|root,COG4865@2|Bacteria,1TS6B@1239|Firmicutes,24AYE@186801|Clostridia,2610W@186807|Peptococcaceae 186801|Clostridia E Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate) glmE - 5.4.99.1 ko:K19268 ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200 M00740 R00262 RC01221 ko00000,ko00001,ko00002,ko01000 - - - Met_asp_mut_E k59_1538114_1 997346.HMPREF9374_0715 1.96e-51 172.0 COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,4H9N5@91061|Bacilli,27AV1@186824|Thermoactinomycetaceae 91061|Bacilli J Ribosomal protein S2 rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_1538114_2 1121430.JMLG01000001_gene2166 2.28e-85 258.0 COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,260PI@186807|Peptococcaceae 186801|Clostridia J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_1538114_3 1121468.AUBR01000029_gene1586 7.37e-44 150.0 COG0528@1|root,COG0528@2|Bacteria,1TPXN@1239|Firmicutes,247KR@186801|Clostridia,42EJV@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_1130462_1 1286631.X805_24910 5.69e-16 77.4 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2VIGG@28216|Betaproteobacteria,1KIWS@119065|unclassified Burkholderiales 28216|Betaproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_1130462_2 396588.Tgr7_0597 1.2e-28 111.0 28J26@1|root,2Z8YT@2|Bacteria,1R7S5@1224|Proteobacteria,1RNDH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2914) - - - - - - - - - - - - DUF2914 k59_712316_1 1121403.AUCV01000063_gene4177 5.22e-73 244.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,43EBY@68525|delta/epsilon subdivisions,2X7W0@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_1656532_1 2340.JV46_05690 8.26e-204 572.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L L COG2826 Transposase and inactivated derivatives, IS30 family insI GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K07482 - - - - ko00000 - - - HTH_38,rve k59_762078_1 1340810.V5UTB4_9CAUD 2.17e-09 65.5 4QB3T@10239|Viruses,4QWCJ@35237|dsDNA viruses no RNA stage,4QS7B@28883|Caudovirales,4QK0J@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_553262_1 1232410.KI421420_gene3156 5.15e-68 231.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,43T20@69541|Desulfuromonadales 28221|Deltaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_970916_1 1121123.AUAO01000001_gene890 5.83e-19 90.5 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,2KFVI@204458|Caulobacterales 204458|Caulobacterales S PFAM peptidase M16 domain protein - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_712327_1 330214.NIDE3939 9.58e-13 68.9 COG3829@1|root,COG3829@2|Bacteria 2|Bacteria T transcription factor binding - - - - - - - - - - - - HTH_8,PAS,PilZ,Sigma54_activat k59_712327_2 1150626.PHAMO_340128 2.99e-05 47.8 COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2U06A@28211|Alphaproteobacteria,2JSHZ@204441|Rhodospirillales 204441|Rhodospirillales K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_1078400_1 396588.Tgr7_3073 2.54e-58 194.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMFM@1236|Gammaproteobacteria,1WXWQ@135613|Chromatiales 135613|Chromatiales L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_294785_1 1123261.AXDW01000001_gene1396 4.03e-93 284.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1X570@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_1295676_1 1123368.AUIS01000006_gene604 1.77e-68 223.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,2NCMY@225057|Acidithiobacillales 225057|Acidithiobacillales F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_7,Pribosyltran k59_970919_1 1449049.JONW01000010_gene3522 3.34e-55 189.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 k59_509906_1 1178482.BJB45_19395 2.6e-39 148.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1T3SF@1236|Gammaproteobacteria,1XP4Q@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_921896_2 1197706.AKKK01000004_gene264 8.11e-05 49.3 COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria,1WATB@1268|Micrococcaceae 201174|Actinobacteria O DnaJ molecular chaperone homology domain cbpA - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_453007_1 237609.PSAKL28_33610 1.21e-11 66.2 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve k59_453007_2 1472418.BBJC01000002_gene893 0.000558 42.4 COG2963@1|root,COG2963@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_294796_1 1535422.ND16A_3654 6.7e-22 89.7 COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,1S8W1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM glutathione-dependent formaldehyde-activating - - - - - - - - - - - - GFA k59_294796_2 1163617.SCD_n01404 0.000143 46.2 COG3291@1|root,COG3291@2|Bacteria,1RFUT@1224|Proteobacteria,2VS7V@28216|Betaproteobacteria 28216|Betaproteobacteria S Pkd domain containing protein - - - - - - - - - - - - Peptidase_M10,VPEP k59_553280_1 1304885.AUEY01000002_gene321 3.78e-107 317.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,42P5X@68525|delta/epsilon subdivisions,2WIQW@28221|Deltaproteobacteria,2MI3X@213118|Desulfobacterales 28221|Deltaproteobacteria E Methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_921912_1 1313301.AUGC01000009_gene1058 4.3e-58 190.0 COG0451@1|root,COG0451@2|Bacteria,4NDV4@976|Bacteroidetes 976|Bacteroidetes GM Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction fcl - 1.1.1.271 ko:K02377 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R05692 RC01014 ko00000,ko00001,ko01000 - - - Epimerase k59_346853_1 96561.Dole_2258 1.39e-38 142.0 COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1QZPK@1224|Proteobacteria,42NQE@68525|delta/epsilon subdivisions,2WJPH@28221|Deltaproteobacteria,2MI1D@213118|Desulfobacterales 28221|Deltaproteobacteria T GHKL domain - - - - - - - - - - - - HATPase_c,PAS_4,PAS_9,Response_reg k59_294806_1 1454004.AW11_01634 5.62e-91 296.0 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,2VJSM@28216|Betaproteobacteria,1KQDM@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P Heavy-metal-associated domain ccoI - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_183303_1 1219084.AP014508_gene995 1.12e-15 77.4 COG0383@1|root,COG0383@2|Bacteria,2GCGE@200918|Thermotogae 200918|Thermotogae G PFAM glycoside hydrolase family 38 - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C k59_1388321_1 997829.HMPREF1121_01616 3.09e-06 52.8 COG0793@1|root,COG0793@2|Bacteria,4NFEN@976|Bacteroidetes,2FMMP@200643|Bacteroidia,22WMS@171551|Porphyromonadaceae 976|Bacteroidetes M peptidase S41 - - - - - - - - - - - - Peptidase_S41,Tricorn_C1 k59_346866_1 1120971.AUCA01000057_gene2496 6.92e-07 56.2 COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,4HB5P@91061|Bacilli 91061|Bacilli I AMP-dependent synthetase acs - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1176672_1 944481.JAFP01000001_gene1254 2.67e-66 221.0 COG0019@1|root,COG0019@2|Bacteria,1PKGS@1224|Proteobacteria,42PPS@68525|delta/epsilon subdivisions,2X9TT@28221|Deltaproteobacteria,2M7JX@213113|Desulfurellales 28221|Deltaproteobacteria E Pyridoxal-dependent decarboxylase, C-terminal sheet domain - - - - - - - - - - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_762108_1 1034115.G1D5L0_9CAUD 3.03e-39 140.0 4QCF5@10239|Viruses,4QV2A@35237|dsDNA viruses no RNA stage,4QPJI@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1503261_2 926554.KI912615_gene1763 3.77e-06 54.3 COG0673@1|root,COG0673@2|Bacteria,1WM5A@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_921931_1 765914.ThisiDRAFT_0960 6.78e-90 277.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1WWNX@135613|Chromatiales 135613|Chromatiales E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_1388336_1 177437.HRM2_34570 3.44e-35 132.0 COG0477@1|root,COG2814@2|Bacteria,1R9V9@1224|Proteobacteria,42Q1C@68525|delta/epsilon subdivisions,2WK7P@28221|Deltaproteobacteria,2MMQA@213118|Desulfobacterales 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_668800_1 269796.Rru_A2910 1.01e-26 111.0 COG1463@1|root,COG1463@2|Bacteria,1RCV1@1224|Proteobacteria,2U6E9@28211|Alphaproteobacteria,2JRVS@204441|Rhodospirillales 204441|Rhodospirillales Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_867224_2 96561.Dole_0621 2.2e-37 137.0 COG0845@1|root,COG0845@2|Bacteria,1RC4B@1224|Proteobacteria,42T2B@68525|delta/epsilon subdivisions,2WPEV@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_670010_1 288000.BBta_4201 2.74e-54 195.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria,3JRJK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Penicillin-binding protein OB-like domain mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_296013_1 187272.Mlg_2698 7.3e-185 553.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales 135613|Chromatiales OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_762891_1 502025.Hoch_2165 6.84e-29 118.0 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,42NEZ@68525|delta/epsilon subdivisions,2WJ5R@28221|Deltaproteobacteria 28221|Deltaproteobacteria S AAA domain - - - ko:K07028 - - - - ko00000 - - - AAA_33,APH k59_827193_1 521719.ATXQ01000001_gene616 2.29e-27 108.0 COG1934@1|root,COG1934@2|Bacteria,1N776@1224|Proteobacteria,1RPM7@1236|Gammaproteobacteria,1YENH@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm lptA GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0010876,GO:0015920,GO:0016020,GO:0017089,GO:0019867,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044462,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264 - ko:K09774 - - - - ko00000,ko02000 1.B.42.1 - iB21_1397.B21_03016,iECBD_1354.ECBD_0542,iECB_1328.ECB_03065,iECD_1391.ECD_03065 OstA k59_296030_1 330214.NIDE3373 4.18e-23 97.1 COG1262@1|root,COG1262@2|Bacteria 2|Bacteria T PFAM Formylglycine-generating sulfatase enzyme - - - ko:K20333 ko02024,map02024 - - - ko00000,ko00001 - - - FGE-sulfatase,NACHT k59_1657913_1 1442599.JAAN01000022_gene1736 8.5e-42 153.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,1X3T3@135614|Xanthomonadales 135614|Xanthomonadales EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_1657913_2 1504981.KO116_4648 1.15e-07 55.1 COG0789@1|root,COG0789@2|Bacteria,1RJD4@1224|Proteobacteria,1S8DH@1236|Gammaproteobacteria,1XKGY@135619|Oceanospirillales 135619|Oceanospirillales K Transcriptional - - - - - - - - - - - - MerR,MerR-DNA-bind,MerR_1 k59_713354_1 998674.ATTE01000001_gene511 3.12e-83 259.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,4601Y@72273|Thiotrichales 72273|Thiotrichales F Belongs to the GARS family purD - 6.3.2.6,6.3.4.13 ko:K01945,ko:K13713 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N,SAICAR_synt k59_348187_1 268746.Q58MM0_BPPRM 3.42e-97 296.0 4QHPV@10239|Viruses,4QWVT@35237|dsDNA viruses no RNA stage,4QTVP@28883|Caudovirales,4QICC@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1598530_1 768704.Desmer_2320 1.01e-08 55.5 COG0686@1|root,COG0686@2|Bacteria,1TNZ5@1239|Firmicutes,2489D@186801|Clostridia,260WZ@186807|Peptococcaceae 186801|Clostridia C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_1598530_2 1048983.EL17_04755 2.12e-26 107.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,4NE4A@976|Bacteroidetes,47KBI@768503|Cytophagia 976|Bacteroidetes C Dehydrogenase E1 component pdhB - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_827220_1 1122599.AUGR01000001_gene229 2.93e-42 158.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XI40@135619|Oceanospirillales 135619|Oceanospirillales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - 5TM-5TMR_LYT,EAL,GGDEF,PAS_9 k59_1333808_1 29581.BW37_04969 1.02e-91 276.0 COG4525@1|root,COG4525@2|Bacteria,1QTUA@1224|Proteobacteria,2VIKA@28216|Betaproteobacteria,476MM@75682|Oxalobacteraceae 28216|Betaproteobacteria P Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system tauB - 3.6.3.36 ko:K10831 ko00920,ko02010,map00920,map02010 M00435 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.17.1,3.A.1.17.4 - - ABC_tran k59_1504669_1 1122135.KB893134_gene3130 6.53e-90 277.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2TU8Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3,CTP_transf_3 k59_140980_1 1279017.AQYJ01000022_gene2608 2.29e-53 178.0 COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria,466ZS@72275|Alteromonadaceae 1236|Gammaproteobacteria S Secreted protein, containing von Willebrand factor - - - - - - - - - - - - - k59_971898_1 159749.E7BWK2 1.72e-118 345.0 COG0755@1|root,2QU0T@2759|Eukaryota,2XFBW@2836|Bacillariophyta 2836|Bacillariophyta P Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment ccsA - - - - - - - - - - - Cytochrom_C_asm k59_971898_2 35128.Thapsdraft1447 7.25e-14 65.9 28RUB@1|root,2QYHP@2759|Eukaryota,2XG8B@2836|Bacillariophyta 2836|Bacillariophyta J Binds together with S18 to 16S ribosomal RNA rps6 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0019843,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0070181,GO:0097159,GO:1901363 - - - - - - - - - - Ribosomal_S6 k59_1240204_1 330214.NIDE1399 8.86e-66 205.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity - - - - - - - - - - - - AhpC-TSA k59_1131761_1 309801.trd_1918 4.64e-29 112.0 COG3970@1|root,COG3970@2|Bacteria,2G6JI@200795|Chloroflexi,27YVJ@189775|Thermomicrobia 189775|Thermomicrobia S Fumarylacetoacetate (FAA) hydrolase family - - 4.2.1.141 ko:K14259 ko00040,map00040 - R09186 RC00429 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_1131761_2 1121004.ATVC01000034_gene2258 1.57e-19 87.0 COG0679@1|root,COG0679@2|Bacteria,1P2SH@1224|Proteobacteria,2VNH9@28216|Betaproteobacteria,2KQWI@206351|Neisseriales 206351|Neisseriales S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_1177627_1 926549.KI421517_gene3224 3.48e-83 264.0 COG2225@1|root,COG2225@2|Bacteria,4NF5H@976|Bacteroidetes,47JKU@768503|Cytophagia 976|Bacteroidetes C Malate synthase - - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_399234_1 321327.CYA_2683 2.72e-23 101.0 COG0003@1|root,COG0003@2|Bacteria,1G1UB@1117|Cyanobacteria,1GYPY@1129|Synechococcus 1117|Cyanobacteria P Anion-transporting ATPase - - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase k59_929672_2 246197.MXAN_1823 3.68e-28 107.0 2CGYE@1|root,3355Z@2|Bacteria,1NJNH@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1339118_1 999423.HMPREF9161_00839 3.03e-10 65.9 COG1629@1|root,COG4771@2|Bacteria,1UK28@1239|Firmicutes,4H9AZ@909932|Negativicutes 909932|Negativicutes P TonB-dependent receptor - - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_1513317_1 1166948.JPZL01000001_gene2232 1.96e-10 67.8 COG2199@1|root,COG3706@2|Bacteria,1R8M0@1224|Proteobacteria,1S0A3@1236|Gammaproteobacteria,1XR49@135619|Oceanospirillales 135619|Oceanospirillales T CHASE4 domain - - - - - - - - - - - - CHASE4,GGDEF k59_247616_1 526222.Desal_0401 5.3e-24 104.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2M9D6@213115|Desulfovibrionales 28221|Deltaproteobacteria NU PFAM type II secretion system gspF - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF k59_1666791_1 95619.PM1_0204890 6.39e-63 205.0 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Lytic murein transglycosylase mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_405177_1 1380390.JIAT01000009_gene2198 9.11e-06 50.1 COG0265@1|root,COG0265@2|Bacteria,2INQH@201174|Actinobacteria 201174|Actinobacteria O Domain present in PSD-95, Dlg, and ZO-1/2. - - - - - - - - - - - - PDZ_2,Trypsin_2 k59_1030645_2 1085623.GNIT_0114 2.02e-26 108.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,464P3@72275|Alteromonadaceae 1236|Gammaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family fadN - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1245983_1 247490.KSU1_C1031 1.01e-19 88.2 COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2IZRY@203682|Planctomycetes 203682|Planctomycetes S Peptidase family M50 - - - - - - - - - - - - CBS,Peptidase_M50 k59_1245983_2 869213.JCM21142_93880 8.12e-19 86.7 COG0484@1|root,COG0484@2|Bacteria,4NF41@976|Bacteroidetes,47MD9@768503|Cytophagia 976|Bacteroidetes O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_405183_1 1123024.AUII01000021_gene49 8.81e-49 167.0 COG0346@1|root,COG0346@2|Bacteria,2GM8H@201174|Actinobacteria,4DYGP@85010|Pseudonocardiales 201174|Actinobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - 1.13.11.25 ko:K11945,ko:K16049 ko00624,ko00984,ko01100,ko01120,ko01220,map00624,map00984,map01100,map01120,map01220 - R04597,R05650 RC01443,RC01610 ko00000,ko00001,ko01000 - - - Glyoxalase k59_1544961_1 717774.Marme_0329 5.01e-86 263.0 COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria,1RPPC@1236|Gammaproteobacteria,1XHQN@135619|Oceanospirillales 135619|Oceanospirillales P TIGRFAM 2-aminoethylphosphonate ABC transport system, 1-aminoethylphosphonate-binding protein component - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 k59_1245986_1 1033743.CAES01000033_gene1025 1.24e-79 241.0 COG2818@1|root,COG2818@2|Bacteria,1UYWG@1239|Firmicutes,4HGWW@91061|Bacilli,26TEW@186822|Paenibacillaceae 91061|Bacilli L DNA-3-methyladenine glycosylase tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_929712_1 713586.KB900536_gene3074 8.37e-44 150.0 2E55J@1|root,32ZYF@2|Bacteria,1N9FR@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1138170_1 187272.Mlg_1298 4.27e-34 124.0 COG1142@1|root,COG1142@2|Bacteria,1MWE1@1224|Proteobacteria,1T2WV@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4,Fer4_11,Fer4_4 k59_1138170_2 1123371.ATXH01000002_gene382 4.92e-30 119.0 COG2414@1|root,COG2414@2|Bacteria,2GGWI@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C Aldehyde ferredoxin oxidoreductase, N-terminal domain - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_1544973_1 318829.MGG_17829T0 2.35e-18 88.2 COG2055@1|root,2QRW5@2759|Eukaryota,38RRZ@33154|Opisthokonta,3NYKR@4751|Fungi,3QPRT@4890|Ascomycota,211XY@147550|Sordariomycetes,41IYQ@639021|Magnaporthales 4751|Fungi C Malate/L-lactate dehydrogenase - - - - - - - - - - - - Ldh_2 k59_874199_1 1297742.A176_03524 3.78e-40 140.0 COG1959@1|root,COG1959@2|Bacteria,1N0E2@1224|Proteobacteria,42VZX@68525|delta/epsilon subdivisions,2WYIT@28221|Deltaproteobacteria,2YW0H@29|Myxococcales 28221|Deltaproteobacteria K Transcriptional regulator - - - - - - - - - - - - Rrf2 k59_769098_1 429009.Adeg_0300 4.42e-14 73.2 COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,249X0@186801|Clostridia,42GDI@68295|Thermoanaerobacterales 186801|Clostridia S Belongs to the UPF0173 family - - - - - - - - - - - - Lactamase_B_2,Lactamase_B_3 k59_247650_1 1156937.MFUM_940009 2.79e-14 71.2 COG0839@1|root,COG0839@2|Bacteria,46T5P@74201|Verrucomicrobia,37GUV@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia C NADH-ubiquinone/plastoquinone oxidoreductase chain 6 nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_247650_2 992406.RIA_1530 6.83e-10 61.2 COG1005@1|root,COG1005@2|Bacteria,4NGK7@976|Bacteroidetes,1HY4Q@117743|Flavobacteriia 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_460016_1 1223543.GP2_013_00280 4.82e-22 99.4 COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4GAY3@85026|Gordoniaceae 201174|Actinobacteria S Transporter associated domain corC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1138192_1 1232683.ADIMK_1592 5.85e-39 148.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,465GZ@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD k59_520114_1 105559.Nwat_1681 3.75e-81 264.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,LysM k59_1666846_1 1121434.AULY01000008_gene261 1.45e-68 235.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,2M7ZN@213115|Desulfovibrionales 28221|Deltaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_679041_1 292459.STH1274 1.29e-68 224.0 COG0076@1|root,COG0076@2|Bacteria,1TPVX@1239|Firmicutes,2493I@186801|Clostridia 186801|Clostridia E Belongs to the group II decarboxylase family - - 4.1.2.27 ko:K01634 ko00600,ko01100,ko04071,map00600,map01100,map04071 M00100 R02464,R06516 RC00264,RC00721,RC01266 ko00000,ko00001,ko00002,ko01000 - - - Pyridoxal_deC k59_146793_1 477184.KYC_08425 1.25e-57 192.0 COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,2VIDZ@28216|Betaproteobacteria,3T2AT@506|Alcaligenaceae 28216|Betaproteobacteria P COG4597 ABC-type amino acid transport system, permease component - - - ko:K09970 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_1030689_1 344747.PM8797T_28774 4.07e-15 80.1 COG1572@1|root,COG3210@1|root,COG4625@1|root,COG1572@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria,2J27Z@203682|Planctomycetes 203682|Planctomycetes U domain, Protein - - - - - - - - - - - - PATR k59_460032_1 305700.B447_18944 4.09e-86 266.0 COG0683@1|root,COG0683@2|Bacteria,1MWGW@1224|Proteobacteria,2VK6Q@28216|Betaproteobacteria,2KXTM@206389|Rhodocyclales 206389|Rhodocyclales E ABC transporter substrate-binding protein - - - - - - - - - - - - Peripla_BP_6 k59_1545001_1 1000565.METUNv1_00206 4.03e-19 87.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2VHX4@28216|Betaproteobacteria,2KV65@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the FPP GGPP synthase family ispB - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_1545001_2 882.DVU_1185 3.1e-07 55.8 COG1286@1|root,COG1286@2|Bacteria,1RJE1@1224|Proteobacteria,42SCW@68525|delta/epsilon subdivisions,2WPNX@28221|Deltaproteobacteria,2MDHW@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM Colicin V production protein - - - ko:K03558 - - - - ko00000 - - - Colicin_V k59_405234_2 35128.Thapsdraft2063 4.25e-83 257.0 COG3854@1|root,2QQ4X@2759|Eukaryota,2XEFS@2836|Bacillariophyta 2836|Bacillariophyta L AAA domain ycf45 - - - - - - - - - - - - k59_1394568_2 1173021.ALWA01000012_gene1168 0.000776 45.8 COG0038@1|root,COG0517@1|root,COG0589@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,COG0589@2|Bacteria,1G17J@1117|Cyanobacteria 1117|Cyanobacteria PT Chloride channel eriC - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Usp,Voltage_CLC k59_1513431_1 243233.MCA3004 6.27e-93 290.0 COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1NR3M@1224|Proteobacteria,1T1WT@1236|Gammaproteobacteria,1XGD0@135618|Methylococcales 135618|Methylococcales P Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_770244_1 107635.AZUO01000005_gene4352 4.7e-33 123.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,36XYF@31993|Methylocystaceae 28211|Alphaproteobacteria S Polyphosphate kinase 2 (PPK2) - - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 k59_875405_1 187272.Mlg_1362 1.48e-66 221.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1WWEF@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_1139320_1 379066.GAU_3535 4.85e-17 80.9 2DBN7@1|root,2ZA2Y@2|Bacteria,1ZUIR@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4159) - - - - - - - - - - - - DUF4159 k59_1139320_2 595460.RRSWK_02330 2.29e-06 51.2 COG0457@1|root,COG0457@2|Bacteria,2IWTH@203682|Planctomycetes 203682|Planctomycetes S Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - - - - - - - - - - Peptidase_MA_2,TPR_16,TPR_19 k59_1668532_1 314278.NB231_09783 2.11e-59 193.0 COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria,1WWKH@135613|Chromatiales 135613|Chromatiales IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_102537_1 296591.Bpro_4279 4.97e-52 185.0 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria 28216|Betaproteobacteria E Spermine/spermidine synthase domain - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_521679_1 518766.Rmar_0337 6.73e-25 107.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,4NEP3@976|Bacteroidetes,1FIWT@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Pyruvate:ferredoxin oxidoreductase core domain II porA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1395557_2 1128421.JAGA01000003_gene3229 2.84e-31 119.0 COG2890@1|root,COG2890@2|Bacteria 2|Bacteria J protein-(glutamine-N5) methyltransferase activity - - - - - - - - - - - - Methyltransf_25,NodS,PIG-L k59_1183976_1 998674.ATTE01000001_gene3691 1.45e-18 83.2 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,460V0@72273|Thiotrichales 72273|Thiotrichales K Bacterial regulatory helix-turn-helix protein, lysR family - - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_1183976_2 1236542.BALM01000016_gene1356 4.01e-41 139.0 COG0783@1|root,COG0783@2|Bacteria,1RAC5@1224|Proteobacteria,1S2H7@1236|Gammaproteobacteria,2QBUR@267890|Shewanellaceae 1236|Gammaproteobacteria P Belongs to the Dps family dps - - ko:K04047 - - - - ko00000,ko03036 - - - Ferritin k59_1668556_1 670292.JH26_02420 2.4e-106 334.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Adenylate cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,TPR_2,TPR_8 k59_1546316_1 472759.Nhal_3822 1.48e-87 271.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales 135613|Chromatiales P PFAM TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_1546316_2 396588.Tgr7_0202 1.53e-23 99.8 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales 135613|Chromatiales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_978117_1 1415780.JPOG01000001_gene28 6.82e-14 77.4 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1X4DT@135614|Xanthomonadales 135614|Xanthomonadales G Na melibiose symporter and related transporters ynaJ - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_1183984_1 1297863.APJF01000038_gene1765 2.15e-15 84.7 COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,2TV0G@28211|Alphaproteobacteria,3K6XF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_4,PAS_7 k59_406556_1 365528.KB891262_gene5089 2.01e-32 125.0 COG2124@1|root,COG2124@2|Bacteria,2GJ3T@201174|Actinobacteria 201174|Actinobacteria Q cytochrome P450 - - - - - - - - - - - - p450 k59_613512_1 331869.BAL199_06324 1.45e-90 290.0 COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Methionine synthase metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_875444_1 216594.MMAR_4340 2.35e-46 160.0 COG2114@1|root,COG2114@2|Bacteria,2I8W5@201174|Actinobacteria,234SY@1762|Mycobacteriaceae 201174|Actinobacteria T PFAM Adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - Guanylate_cyc k59_875444_2 1116472.MGMO_36c00110 9.41e-16 78.6 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1XF7M@135618|Methylococcales 135618|Methylococcales G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_561761_1 631454.N177_0072 1.25e-77 248.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,1JNY6@119043|Rhodobiaceae 28211|Alphaproteobacteria EQ Hydantoinase B/oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_18958_1 1242864.D187_008070 9.03e-88 273.0 COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2WJ6D@28221|Deltaproteobacteria,2YTZV@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans k59_18958_2 862908.BMS_2518 1.78e-05 45.8 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2MSV5@213481|Bdellovibrionales,2WIZ2@28221|Deltaproteobacteria 213481|Bdellovibrionales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_102582_1 1207055.C100_18070 1.02e-70 231.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria 28211|Alphaproteobacteria EQ N-methylhydantoinase B acetone carboxylase alpha subunit - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_248822_1 1049564.TevJSym_bn00090 1.41e-51 176.0 COG0810@1|root,COG0810@2|Bacteria,1R330@1224|Proteobacteria,1RQAX@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Periplasmic protein TonB links inner and outer membranes - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_248822_2 1122236.KB905141_gene1389 6.17e-16 75.1 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2VJQA@28216|Betaproteobacteria,2KMR8@206350|Nitrosomonadales 206350|Nitrosomonadales K Belongs to the UPF0301 (AlgH) family - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_1546346_1 444157.Tneu_0419 2.28e-11 71.6 COG1062@1|root,arCOG01456@2157|Archaea,2XRMG@28889|Crenarchaeota 28889|Crenarchaeota C alcohol dehydrogenase - - - ko:K14465 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00374,M00375 R09281 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N k59_356008_1 1510531.JQJJ01000009_gene793 1.31e-36 132.0 COG0596@1|root,COG0596@2|Bacteria,1MUVB@1224|Proteobacteria,2TREP@28211|Alphaproteobacteria,3JWVC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Alpha/beta hydrolase family dehH - 3.8.1.3 ko:K01561 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_356008_2 443144.GM21_1742 8.68e-34 122.0 COG1335@1|root,COG1335@2|Bacteria,1RDHA@1224|Proteobacteria,42S3C@68525|delta/epsilon subdivisions,2X5QU@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_147940_1 1049564.TevJSym_bu00070 2.17e-37 130.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1J5V2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_147940_2 523791.Kkor_0429 2.42e-16 73.9 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,1S5V7@1236|Gammaproteobacteria,1XJXD@135619|Oceanospirillales 135619|Oceanospirillales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_1139382_1 243233.MCA1504 9.13e-195 553.0 COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,1RP2M@1236|Gammaproteobacteria,1XGME@135618|Methylococcales 135618|Methylococcales S Mo-co oxidoreductase dimerisation domain - - - ko:K17225 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - Mo-co_dimer,Oxidored_molyb k59_406573_2 641491.DND132_1169 4.49e-10 58.2 COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,42SKP@68525|delta/epsilon subdivisions,2WNEV@28221|Deltaproteobacteria,2MBNA@213115|Desulfovibrionales 28221|Deltaproteobacteria S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily - - - ko:K03976 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_1668606_1 868131.MSWAN_2326 1.39e-41 152.0 COG1950@1|root,arCOG09731@2157|Archaea,2Y2F9@28890|Euryarchaeota,23PAN@183925|Methanobacteria 183925|Methanobacteria S Mycobacterial 4 TMS phage holin, superfamily IV - - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2,Phosphodiest k59_613541_1 1380386.JIAW01000013_gene2466 4.8e-30 122.0 COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,2IASU@201174|Actinobacteria,23CKV@1762|Mycobacteriaceae 201174|Actinobacteria IT Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6,Guanylate_cyc k59_18967_2 1123367.C666_18150 1.71e-42 144.0 COG3671@1|root,COG3671@2|Bacteria,1N51H@1224|Proteobacteria,2VUKZ@28216|Betaproteobacteria,2KWZK@206389|Rhodocyclales 206389|Rhodocyclales S membrane - - - - - - - - - - - - - k59_1454259_1 713586.KB900536_gene1421 1.9e-72 228.0 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,1S02U@1236|Gammaproteobacteria,1WX9F@135613|Chromatiales 135613|Chromatiales T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_988604_1 1439940.BAY1663_01811 2.42e-36 138.0 COG0004@1|root,COG5001@1|root,COG0004@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - 2.1.1.80,3.1.1.61 ko:K03320,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02000,ko02022,ko02035 1.A.11 - - Ammonium_transp,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_988604_2 867900.Celly_2204 5.16e-05 44.7 COG0031@1|root,COG0031@2|Bacteria,4NDZ9@976|Bacteroidetes,1HX09@117743|Flavobacteriia,1F8YW@104264|Cellulophaga 976|Bacteroidetes H PFAM Pyridoxal phosphate-dependent enzyme, beta subunit - - 4.2.1.22 ko:K01697 ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 M00035,M00338 R00891,R01290,R04942 RC00056,RC00069,RC00256,RC00489,RC01246 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP k59_417845_2 292459.STH1787 6.54e-24 97.1 COG2715@1|root,COG2715@2|Bacteria,1V1E2@1239|Firmicutes,249G0@186801|Clostridia 186801|Clostridia S membrane protein required for spore maturation spmA - - ko:K06373 - - - - ko00000 - - - Gate k59_417847_1 1110502.TMO_0540 2.07e-25 101.0 COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TRQ7@28211|Alphaproteobacteria,2JR8D@204441|Rhodospirillales 204441|Rhodospirillales T Universal stress protein UspA - - - - - - - - - - - - Usp k59_417847_2 697282.Mettu_0374 1.37e-46 155.0 COG0517@1|root,COG0517@2|Bacteria,1QJRF@1224|Proteobacteria,1THSQ@1236|Gammaproteobacteria,1XFJQ@135618|Methylococcales 135618|Methylococcales S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_417856_1 666685.R2APBS1_1296 1.18e-25 95.5 COG0053@1|root,COG0053@2|Bacteria,1N8A3@1224|Proteobacteria,1SDJW@1236|Gammaproteobacteria,1XB32@135614|Xanthomonadales 1236|Gammaproteobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - - k59_417856_2 1530186.JQEY01000033_gene1843 5.86e-06 50.8 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria 28211|Alphaproteobacteria P P-type ATPase' actP - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_570500_1 1208321.D104_02050 9.65e-46 158.0 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1XIXM@135619|Oceanospirillales 135619|Oceanospirillales O peptidase - - - - - - - - - - - - Peptidase_M48 k59_257488_1 1283300.ATXB01000001_gene1981 2.32e-90 284.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,1XDYX@135618|Methylococcales 135618|Methylococcales IQ TIGRFAM Amino acid adenylation - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_625020_2 1037409.BJ6T_61730 1.9e-50 176.0 COG0845@1|root,COG3409@1|root,COG0845@2|Bacteria,COG3409@2|Bacteria 2|Bacteria M Peptidoglycan-binding domain 1 protein - - 3.2.1.35 ko:K01197,ko:K02022 ko00531,ko01100,map00531,map01100 M00076,M00077 R07824,R07825,R10905 - ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042 - - - Biotin_lipoyl_2,HlyD_3,PG_binding_1,YkuD k59_1557446_1 445686.E3SKU6_9CAUD 6.94e-69 235.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_202985_1 13249.RPRC003010-PA 2.21e-114 357.0 COG1877@1|root,KOG1050@2759|Eukaryota,38EGS@33154|Opisthokonta,3BMA5@33208|Metazoa,3CWD5@33213|Bilateria,41VGH@6656|Arthropoda,3SJ1W@50557|Insecta,3E8RS@33342|Paraneoptera 33208|Metazoa G Trehalose-phosphatase Tps1 GO:0003674,GO:0003824,GO:0004805,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044464,GO:0046351,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:1901576 2.4.1.15,3.1.3.12 ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,Trehalose_PPase k59_203000_1 330214.NIDE4388 4.46e-82 269.0 COG3002@1|root,COG3002@2|Bacteria,3J0VY@40117|Nitrospirae 40117|Nitrospirae S Uncharacterized protein conserved in bacteria (DUF2309) - - - ko:K09822 - - - - ko00000 - - - DUF2309 k59_1406227_1 1333998.M2A_0365 1.99e-103 310.0 COG1633@1|root,COG1633@2|Bacteria,1R02H@1224|Proteobacteria,2TYHQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_625072_2 1173026.Glo7428_0408 8.63e-44 163.0 COG0438@1|root,COG0438@2|Bacteria,1G12R@1117|Cyanobacteria 1117|Cyanobacteria M synthase susA - 2.4.1.13 ko:K00695 ko00500,ko01100,map00500,map01100 - R00806 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000,ko01003 - GT4 - Glycos_transf_1,Sucrose_synth k59_1194748_1 338963.Pcar_0532 3.03e-89 273.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,43TYM@69541|Desulfuromonadales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_780978_1 1869.MB27_42465 1.52e-12 70.1 COG1231@1|root,COG1231@2|Bacteria,2GK23@201174|Actinobacteria,4DF00@85008|Micromonosporales 201174|Actinobacteria E Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,cNMP_binding k59_1197616_2 472759.Nhal_0023 2.09e-84 264.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1WVY6@135613|Chromatiales 135613|Chromatiales G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_1409088_1 1123368.AUIS01000016_gene2527 9.95e-57 190.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,2NCEA@225057|Acidithiobacillales 225057|Acidithiobacillales M Lipoprotein releasing system transmembrane protein LolC - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_1409094_1 330214.NIDE4060 3.17e-122 358.0 COG1858@1|root,COG1858@2|Bacteria,3J0GH@40117|Nitrospirae 40117|Nitrospirae C Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_1561450_1 1125863.JAFN01000001_gene2518 7.51e-41 157.0 COG0840@1|root,COG0840@2|Bacteria,1RA20@1224|Proteobacteria,42QNV@68525|delta/epsilon subdivisions,2WMT1@28221|Deltaproteobacteria 28221|Deltaproteobacteria NT histidine kinase HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_260112_1 1229909.NSED_08410 1.48e-46 158.0 COG0731@1|root,arCOG04174@2157|Archaea,41SBS@651137|Thaumarchaeota 651137|Thaumarchaeota C Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) taw1 - 4.1.3.44 ko:K15449 - - - - ko00000,ko01000,ko03016 - - - Radical_SAM,Wyosine_form k59_260112_2 436308.Nmar_1528 1.6e-15 75.9 arCOG07561@1|root,arCOG07561@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - TSP_3,VWA k59_206955_1 290397.Adeh_0736 6.33e-103 326.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2YU97@29|Myxococcales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_260116_2 1071085.KK033114_gene255 1.59e-58 196.0 COG0318@1|root,arCOG00856@2157|Archaea,2XSZG@28890|Euryarchaeota,23S87@183963|Halobacteria 183963|Halobacteria I COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1353703_2 466038.KI421440_gene924 2.45e-40 144.0 COG4175@1|root,COG4175@2|Bacteria,1MU86@1224|Proteobacteria,2TS8Y@28211|Alphaproteobacteria,4BPTN@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E TIGRFAM glycine betaine L-proline transport ATP binding subunit - - 3.6.3.32 ko:K02000 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.12 - - ABC_tran k59_206988_3 493475.GARC_1060 1.2e-19 88.2 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,1RYN7@1236|Gammaproteobacteria,46BC6@72275|Alteromonadaceae 1236|Gammaproteobacteria P Ring hydroxylating alpha subunit (catalytic domain) - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_573188_1 330214.NIDE0427 1.5e-75 234.0 COG0616@1|root,COG0616@2|Bacteria,3J0J0@40117|Nitrospirae 40117|Nitrospirae OU Peptidase family S49 - - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_886222_1 247634.GPB2148_744 2.21e-51 172.0 COG1028@1|root,COG1028@2|Bacteria,1MXVZ@1224|Proteobacteria,1RRUK@1236|Gammaproteobacteria,1J5NX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_573203_1 404589.Anae109_3471 4.34e-56 181.0 COG5483@1|root,COG5483@2|Bacteria,1RDGV@1224|Proteobacteria,42WDP@68525|delta/epsilon subdivisions,2WRK2@28221|Deltaproteobacteria,2YVP5@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function, DUF488 - - - - - - - - - - - - DUF488 k59_207029_1 330214.NIDE0859 1.34e-141 405.0 COG0761@1|root,COG0761@2|Bacteria,3J0PP@40117|Nitrospirae 40117|Nitrospirae IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_573223_1 460265.Mnod_6692 1.76e-139 402.0 COG0329@1|root,COG0329@2|Bacteria,1MXI1@1224|Proteobacteria,2TTWT@28211|Alphaproteobacteria,1JX00@119045|Methylobacteriaceae 28211|Alphaproteobacteria EM Belongs to the DapA family MA20_04665 - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_573225_1 944435.AXAJ01000001_gene193 2.48e-34 134.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VHST@28216|Betaproteobacteria,1JZV1@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.76 ko:K15785 ko00260,map00260 - R06977 RC00006,RC00062 ko00000,ko00001,ko01000 - - - Aminotran_3 k59_260193_1 545276.KB898727_gene453 4e-61 210.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales 135613|Chromatiales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_1197738_1 697282.Mettu_4360 1.2e-51 176.0 COG0019@1|root,COG0019@2|Bacteria,1MW3T@1224|Proteobacteria,1RP8C@1236|Gammaproteobacteria,1XE2W@135618|Methylococcales 135618|Methylococcales H Belongs to the Orn Lys Arg decarboxylase class-II family. NspC subfamily nspC - 4.1.1.96 ko:K13747 ko00330,ko01100,map00330,map01100 - R09081,R09082 RC00299 ko00000,ko00001,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1613901_1 1499967.BAYZ01000158_gene430 7.18e-23 103.0 COG1200@1|root,COG1200@2|Bacteria,2NNS3@2323|unclassified Bacteria 2|Bacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_1197757_1 268746.Q58MD9_BPPRM 2.19e-27 106.0 4QG02@10239|Viruses,4QZDU@35237|dsDNA viruses no RNA stage,4QTM9@28883|Caudovirales,4QJIP@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1409244_1 1463920.JOGB01000013_gene383 2.53e-05 52.8 COG1874@1|root,COG3119@1|root,COG1874@2|Bacteria,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria 201174|Actinobacteria P Pfam Sulfatase - - - - - - - - - - - - NPCBM,NPCBM_assoc,Sulfatase k59_1353828_1 1408254.T458_21700 1.93e-27 114.0 COG1975@1|root,COG1975@2|Bacteria,1URM5@1239|Firmicutes,4HEI3@91061|Bacilli,26WVE@186822|Paenibacillaceae 91061|Bacilli O XdhC Rossmann domain - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_207191_1 481448.Minf_0142 6.08e-34 127.0 COG4798@1|root,COG4798@2|Bacteria,46T4I@74201|Verrucomicrobia,37GDY@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia S Met-10+ like-protein - - - - - - - - - - - - Methyltransf_31 k59_1613953_1 1122917.KB899659_gene5590 2.47e-06 51.6 COG1051@1|root,COG1051@2|Bacteria,1VAMK@1239|Firmicutes,4HKCB@91061|Bacilli,26Y7J@186822|Paenibacillaceae 91061|Bacilli F Belongs to the Nudix hydrolase family apfA - 3.6.1.61 ko:K18445 ko00230,map00230 - R00184 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_1353856_2 330214.NIDE2870 3.34e-52 173.0 COG0451@1|root,COG0451@2|Bacteria,3J0BW@40117|Nitrospirae 40117|Nitrospirae M 3-beta hydroxysteroid dehydrogenase/isomerase family - - 4.1.1.35,4.2.1.46 ko:K01710,ko:K08678 ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00793 R01384,R06513 RC00402,RC00508 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_207244_1 1121456.ATVA01000012_gene2522 6.78e-68 213.0 COG4313@1|root,COG4313@2|Bacteria,1N1DR@1224|Proteobacteria,432MC@68525|delta/epsilon subdivisions,2WXBW@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Protein involved in meta-pathway of phenol degradation - - - - - - - - - - - - - k59_886381_1 103733.JNYO01000027_gene2465 3.52e-17 85.9 COG4992@1|root,COG4992@2|Bacteria,2GK0J@201174|Actinobacteria,4DZYH@85010|Pseudonocardiales 201174|Actinobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family rocD - 2.6.1.13 ko:K00819 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R00667 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_886385_1 521000.PROVRETT_06583 1.75e-13 76.6 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,3Z8SE@586|Providencia 1236|Gammaproteobacteria M Transfers the fatty acyl group on membrane lipoproteins lnt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016021,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576 - ko:K03820 - - - - ko00000,ko01000 - GT2 iEcSMS35_1347.EcSMS35_0678,iSbBS512_1146.SbBS512_E0590 CN_hydrolase k59_207259_2 1120953.AUBH01000005_gene2449 1.85e-89 265.0 COG5472@1|root,COG5472@2|Bacteria,1RI0Q@1224|Proteobacteria,1SAYN@1236|Gammaproteobacteria,4699W@72275|Alteromonadaceae 1236|Gammaproteobacteria S Predicted small integral membrane protein (DUF2165) - - - - - - - - - - - - DUF2165 k59_886389_1 743722.Sph21_0028 1.87e-18 89.7 COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,1IQN0@117747|Sphingobacteriia 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_1613978_1 883103.HMPREF9703_01058 2.37e-19 83.6 COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,4HIK3@91061|Bacilli,27GF0@186828|Carnobacteriaceae 91061|Bacilli J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_1613978_2 445972.ANACOL_00746 3.8e-11 62.4 COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,3WKWI@541000|Ruminococcaceae 186801|Clostridia L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_1197853_1 491205.JARQ01000008_gene3842 1.34e-15 76.6 COG4874@1|root,COG4874@2|Bacteria,4NFG3@976|Bacteroidetes,1HX0R@117743|Flavobacteriia,3ZPA1@59732|Chryseobacterium 976|Bacteroidetes S Amidinotransferase - - - - - - - - - - - - Amidinotransf k59_24410_1 744979.R2A130_1222 1.94e-23 101.0 COG4664@1|root,COG4665@1|root,COG4664@2|Bacteria,COG4665@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system large permease component - - - - - - - - - - - - DctM,DctQ k59_24410_2 1400525.JNIU01000001_gene500 4.39e-81 256.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,4BRA7@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q TIGRFAM TRAP transporter, DctM subunit - - - - - - - - - - - - DctM,DctQ k59_1197865_1 1380394.JADL01000001_gene2569 3.82e-05 45.1 2EDW0@1|root,32VXH@2|Bacteria,1R3JT@1224|Proteobacteria,2U03S@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1197865_2 472759.Nhal_2009 3.57e-55 184.0 COG4783@1|root,COG4783@2|Bacteria,1RAJB@1224|Proteobacteria,1SA1F@1236|Gammaproteobacteria,1X0C0@135613|Chromatiales 135613|Chromatiales S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_260349_1 765912.Thimo_3609 3.64e-43 149.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,1WX1Y@135613|Chromatiales 135613|Chromatiales K transcriptional regulatory protein - - - - - - - - - - - - Transcrip_reg k59_260349_2 1469245.JFBG01000002_gene442 5.11e-21 89.7 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1WW8M@135613|Chromatiales 135613|Chromatiales L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_1561864_1 1121878.AUGL01000005_gene2636 3.65e-38 142.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_207363_1 545276.KB898724_gene1885 8.93e-65 209.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1WW8H@135613|Chromatiales 135613|Chromatiales I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_1561892_1 545276.KB898724_gene1772 1.19e-94 290.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1WVZB@135613|Chromatiales 135613|Chromatiales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_24430_3 1408428.JNJP01000089_gene1222 3.19e-29 116.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2M88K@213115|Desulfovibrionales 28221|Deltaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_207423_1 765910.MARPU_03675 2.9e-38 132.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1WXDE@135613|Chromatiales 135613|Chromatiales J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_1623111_1 1117647.M5M_10885 2.06e-103 315.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,1J5GX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EH Thiamine pyrophosphate enzyme, C-terminal TPP binding domain alsS - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_159315_1 1128421.JAGA01000001_gene2334 2.62e-08 57.0 COG0438@1|root,COG0438@2|Bacteria,2NQ17@2323|unclassified Bacteria 2|Bacteria M glycosyl transferase group 1 bplH - - - - - - - - - - - Glyco_trans_4_2,Glyco_trans_4_4,Glycos_transf_1 k59_1048536_1 1353531.AZNX01000005_gene3261 2.5e-21 99.4 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2U4F6@28211|Alphaproteobacteria,4BCVF@82115|Rhizobiaceae 28211|Alphaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - Spermine_synth k59_212715_1 330214.NIDE0835 1.17e-30 119.0 COG0074@1|root,COG0372@1|root,COG0074@2|Bacteria,COG0372@2|Bacteria 2|Bacteria C Belongs to the citrate synthase family - - 2.3.3.8,6.2.1.5 ko:K01902,ko:K15230,ko:K15233 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00352,R00405,R01322,R02404 RC00004,RC00014,RC00067 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0306 Citrate_synt,CoA_binding,Ligase_CoA,Succ_CoA_lig k59_212715_2 330214.NIDE0836 8.46e-75 243.0 COG1048@1|root,COG1048@2|Bacteria,3J0E6@40117|Nitrospirae 40117|Nitrospirae C Aconitase C-terminal domain - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_891994_1 1123400.KB904754_gene1034 5.28e-33 119.0 COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,1RS1Y@1236|Gammaproteobacteria,460NU@72273|Thiotrichales 72273|Thiotrichales G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 k59_891994_2 511.JT27_08045 1.85e-51 168.0 COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,2VR6S@28216|Betaproteobacteria,3T3NC@506|Alcaligenaceae 28216|Betaproteobacteria H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose aut - 2.7.7.70 ko:K21345 ko00540,ko01100,map00540,map01100 M00064 R05644 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_891995_1 665571.STHERM_c02830 1.16e-99 304.0 COG0174@1|root,COG0174@2|Bacteria,2J6JS@203691|Spirochaetes 203691|Spirochaetes E PFAM Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_1413937_1 1229909.NSED_06385 1.93e-22 94.4 COG0372@1|root,arCOG04237@2157|Archaea,41SAN@651137|Thaumarchaeota 651137|Thaumarchaeota C TIGRFAM 2-methylcitrate synthase citrate synthase II - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_683729_1 572477.Alvin_0395 2.76e-40 146.0 COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,1WWFE@135613|Chromatiales 135613|Chromatiales J Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs truD - 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_735122_2 1305737.JAFX01000001_gene635 4.57e-08 54.7 COG0216@1|root,COG0216@2|Bacteria,4PPXH@976|Bacteroidetes,47YSM@768503|Cytophagia 976|Bacteroidetes J RF-1 domain yaeJ - - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 k59_265043_1 1538295.JY96_01125 1.51e-39 136.0 COG2391@1|root,COG2391@2|Bacteria,1MZC0@1224|Proteobacteria,2VT72@28216|Betaproteobacteria,1KMCS@119065|unclassified Burkholderiales 28216|Betaproteobacteria S transporter component - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_265043_2 640511.BC1002_6746 6.29e-40 138.0 COG2391@1|root,COG2391@2|Bacteria,1MZ3A@1224|Proteobacteria,2VSDD@28216|Betaproteobacteria,1K8TY@119060|Burkholderiaceae 28216|Betaproteobacteria S transporter component - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_56926_2 1385517.N800_00780 1.3e-72 238.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1X4EX@135614|Xanthomonadales 135614|Xanthomonadales J elongation factor G - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_212734_1 436308.Nmar_0333 2.06e-69 235.0 arCOG08778@1|root,arCOG08778@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1100894_1 1217720.ALOX01000111_gene2125 2.58e-87 274.0 COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,2TU4P@28211|Alphaproteobacteria,2JPXU@204441|Rhodospirillales 204441|Rhodospirillales V COG0842 ABC-type multidrug transport system, permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_578361_1 391625.PPSIR1_20459 8.56e-13 67.8 COG1664@1|root,COG1664@2|Bacteria,1N7TF@1224|Proteobacteria,42VWZ@68525|delta/epsilon subdivisions,2WRPF@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_578361_2 1246995.AFR_41810 5.11e-05 48.1 COG2812@1|root,COG5164@1|root,COG2812@2|Bacteria,COG5164@2|Bacteria,2GJKA@201174|Actinobacteria,4DB0V@85008|Micromonosporales 201174|Actinobacteria L DNA polymerase III dnaX GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 k59_735125_1 395493.BegalDRAFT_0740 5.82e-10 60.5 29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,1SBT1@1236|Gammaproteobacteria,463I0@72273|Thiotrichales 72273|Thiotrichales S Domain of unknown function (DUF4390) - - - - - - - - - - - - DUF4390 k59_735125_2 187272.Mlg_2624 2.55e-71 240.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_8 k59_2190_1 2340.JV46_22530 5.72e-57 191.0 COG0845@1|root,COG0845@2|Bacteria,1PDUT@1224|Proteobacteria,1RQKD@1236|Gammaproteobacteria,1JBNA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M HlyD family secretion protein - - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - HlyD_3,HlyD_D23,OEP k59_892011_1 1303518.CCALI_01855 2.53e-114 347.0 COG0277@1|root,COG0277@2|Bacteria 2|Bacteria C FAD linked oxidase domain protein glcD GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 1.1.2.4,1.1.3.15 ko:K00102,ko:K00104 ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130 - R00197,R00475 RC00042,RC00044 ko00000,ko00001,ko01000 - - iJN746.PP_3745,iLF82_1304.LF82_0831,iNRG857_1313.NRG857_14750 FAD-oxidase_C,FAD_binding_4 k59_788232_1 290397.Adeh_0104 2.98e-24 103.0 COG2887@1|root,COG2887@2|Bacteria 2|Bacteria L Belongs to the helicase family. UvrD subfamily uvrD3 - - - - - - - - - - - AAA_19,PDDEXK_1,UvrD-helicase,UvrD_C k59_1152853_1 1123400.KB904747_gene523 7.78e-85 254.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,460JZ@72273|Thiotrichales 72273|Thiotrichales O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_369568_2 1121127.JAFA01000001_gene894 1.02e-53 186.0 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,2VIKX@28216|Betaproteobacteria,1K2MD@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA polymerase III delta subunit holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta k59_683761_1 1117647.M5M_08905 2.3e-15 74.3 COG1596@1|root,COG1596@2|Bacteria,1RFBH@1224|Proteobacteria,1S35N@1236|Gammaproteobacteria,1J5ZH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG1596 Periplasmic protein involved in polysaccharide export wza - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB k59_683761_2 1382359.JIAL01000001_gene921 2.46e-15 79.0 COG2204@1|root,COG2204@2|Bacteria,3Y41F@57723|Acidobacteria,2JIZR@204432|Acidobacteriia 204432|Acidobacteriia T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_369570_1 383372.Rcas_4299 7.79e-38 137.0 COG0530@1|root,COG0530@2|Bacteria,2G7I2@200795|Chloroflexi 200795|Chloroflexi P PFAM sodium calcium exchanger membrane region - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_1206172_1 686340.Metal_0529 1.4e-86 281.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1XDIX@135618|Methylococcales 135618|Methylococcales E PFAM Bacterial extracellular solute-binding - - - - - - - - - - - - SBP_bac_5 k59_1206172_2 1159870.KB907784_gene2217 4.22e-18 84.3 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2WEDQ@28216|Betaproteobacteria,3T2IB@506|Alcaligenaceae 28216|Betaproteobacteria P ABC-type dipeptide oligopeptide nickel transport systems, permease components oppB - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_735144_1 1042375.AFPL01000046_gene1781 1.42e-133 390.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,1RPNJ@1236|Gammaproteobacteria,464A3@72275|Alteromonadaceae 1236|Gammaproteobacteria G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - ko:K11688,ko:K21395 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_683764_1 933262.AXAM01000033_gene1627 1.23e-70 227.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2WIQD@28221|Deltaproteobacteria,2MJGP@213118|Desulfobacterales 28221|Deltaproteobacteria BQ PFAM Histone deacetylase - - - - - - - - - - - - Hist_deacetyl k59_1206176_1 105559.Nwat_1394 1.29e-28 119.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1WWF6@135613|Chromatiales 135613|Chromatiales M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_1309470_1 1229909.NSED_08685 1.58e-82 253.0 COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota 651137|Thaumarchaeota K Phosphate uptake regulator - - - - - - - - - - - - MazE_antitoxin,PhoU k59_1206184_1 391625.PPSIR1_01774 2.19e-18 84.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42QKW@68525|delta/epsilon subdivisions,2WKH1@28221|Deltaproteobacteria,2YWTQ@29|Myxococcales 1224|Proteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1206184_2 311424.DhcVS_933 3.37e-52 179.0 COG1236@1|root,COG1236@2|Bacteria,2G62G@200795|Chloroflexi,34D19@301297|Dehalococcoidia 301297|Dehalococcoidia J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B_6,RMMBL k59_421786_1 1122201.AUAZ01000032_gene1614 8.01e-106 313.0 COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,46407@72275|Alteromonadaceae 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) yciK GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575 - - - - - - - - - - adh_short k59_56977_2 9305.ENSSHAP00000013258 4e-29 116.0 COG1171@1|root,KOG1251@2759|Eukaryota,38E04@33154|Opisthokonta,3BJ90@33208|Metazoa,3CVU5@33213|Bilateria,48AWK@7711|Chordata,497NJ@7742|Vertebrata,3JCGN@40674|Mammalia,4JZ94@9263|Metatheria 33208|Metazoa ET Serine racemase SRR GO:0000166,GO:0000287,GO:0002237,GO:0003674,GO:0003824,GO:0003941,GO:0005488,GO:0005509,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006090,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007568,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008721,GO:0009058,GO:0009069,GO:0009070,GO:0009410,GO:0009605,GO:0009607,GO:0009617,GO:0009987,GO:0010033,GO:0010243,GO:0014070,GO:0014072,GO:0016020,GO:0016043,GO:0016053,GO:0016594,GO:0016597,GO:0016829,GO:0016840,GO:0016841,GO:0016853,GO:0016854,GO:0016855,GO:0017076,GO:0017144,GO:0018114,GO:0019752,GO:0019842,GO:0019904,GO:0022607,GO:0030165,GO:0030170,GO:0030378,GO:0030554,GO:0031406,GO:0032496,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033993,GO:0035639,GO:0036094,GO:0036361,GO:0036477,GO:0042165,GO:0042221,GO:0042493,GO:0042802,GO:0042803,GO:0042866,GO:0043025,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043207,GO:0043278,GO:0043279,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044297,GO:0044424,GO:0044444,GO:0044464,GO:0045177,GO:0046394,GO:0046416,GO:0046437,GO:0046872,GO:0046983,GO:0047661,GO:0048037,GO:0048513,GO:0048731,GO:0048856,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051704,GO:0051707,GO:0060322,GO:0060359,GO:0065003,GO:0070178,GO:0070179,GO:0070279,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072347,GO:0097159,GO:0097367,GO:0097458,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901698,GO:1901700 4.3.1.19,5.1.1.18 ko:K01754,ko:K12235 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00589,R00996 RC00302,RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1413983_1 83219.PM02_03525 0.00032 46.6 COG1547@1|root,COG1547@2|Bacteria,1N9G9@1224|Proteobacteria,2UGCP@28211|Alphaproteobacteria,3ZXKW@60136|Sulfitobacter 28211|Alphaproteobacteria S Domain of unknown function (DUF309) - - - ko:K09763 - - - - ko00000 - - - DUF309 k59_1413983_2 1122236.KB905146_gene1896 2.29e-122 358.0 COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,2VMU5@28216|Betaproteobacteria,2KNMV@206350|Nitrosomonadales 206350|Nitrosomonadales E Transglutaminase/protease-like homologues - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_1413983_3 746697.Aeqsu_0300 1.21e-07 55.5 COG0526@1|root,COG0526@2|Bacteria,4NNU2@976|Bacteroidetes,1I22P@117743|Flavobacteriia 976|Bacteroidetes CO alkyl hydroperoxide reductase resA - - - - - - - - - - - AhpC-TSA,Redoxin k59_107941_1 479434.Sthe_0838 4.79e-55 184.0 COG0709@1|root,COG0709@2|Bacteria,2G5W4@200795|Chloroflexi,27XGA@189775|Thermomicrobia 189775|Thermomicrobia H Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C k59_578410_1 314230.DSM3645_27698 6.28e-27 114.0 COG3696@1|root,COG3696@2|Bacteria,2IWXA@203682|Planctomycetes 203682|Planctomycetes P AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_1362067_1 1112212.JH584235_gene2540 6.87e-75 236.0 COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,2U0BA@28211|Alphaproteobacteria,2K2ZH@204457|Sphingomonadales 204457|Sphingomonadales S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_1152889_1 1493511.A0A0E3FMD1_9CAUD 1.79e-28 124.0 4QEE7@10239|Viruses,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae 10662|Myoviridae S Pfam:DUF4815 - - - - - - - - - - - - - k59_735169_1 240292.Ava_1206 4.06e-48 171.0 COG0365@1|root,COG0365@2|Bacteria,1G0E7@1117|Cyanobacteria,1HM2H@1161|Nostocales 1117|Cyanobacteria H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_735169_2 42565.FP66_02815 5.98e-34 128.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1XHSG@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the peptidase M24B family pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_1258381_1 292415.Tbd_0566 2.46e-21 87.8 COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2VT8I@28216|Betaproteobacteria,1KT0V@119069|Hydrogenophilales 119069|Hydrogenophilales S Sulfur oxidation protein SoxY - - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY k59_1362076_1 243231.GSU3384 3.79e-18 89.7 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,42M77@68525|delta/epsilon subdivisions,2WM41@28221|Deltaproteobacteria,43SS1@69541|Desulfuromonadales 28221|Deltaproteobacteria I Phospholipase D. Active site motifs. - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_892070_1 1163617.SCD_n02706 9.09e-78 247.0 COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,2VI93@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 k59_57002_1 1056820.KB900633_gene2126 2.47e-46 169.0 COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,2PN69@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M LppC putative lipoprotein lpoA GO:0000270,GO:0003674,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - ko:K07121 - - - - ko00000 - - - LppC k59_107963_1 1047013.AQSP01000059_gene2098 1.8e-72 228.0 COG0451@1|root,COG0451@2|Bacteria,2NQD6@2323|unclassified Bacteria 2|Bacteria GM RmlD substrate binding domain ltd - 4.2.1.45 ko:K01709 ko00520,map00520 - R02426 RC00402 ko00000,ko00001,ko01000 - - - Epimerase k59_317604_1 1122201.AUAZ01000005_gene623 4.43e-09 54.7 COG3462@1|root,COG3462@2|Bacteria,1NGXC@1224|Proteobacteria,1SGF3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Short C-terminal domain - - - ko:K08982 - - - - ko00000 - - - SHOCT k59_1100969_1 378806.STAUR_6918 2.94e-75 235.0 COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,43B0A@68525|delta/epsilon subdivisions,2X6EE@28221|Deltaproteobacteria,2YUMP@29|Myxococcales 28221|Deltaproteobacteria C Dehydrogenase leuB2 - 1.1.1.41,1.1.1.85 ko:K00030,ko:K00052 ko00020,ko00290,ko00660,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00660,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00432,M00535 R00709,R00994,R04426,R10052 RC00084,RC00114,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_995953_1 443143.GM18_4037 2.15e-29 123.0 COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria,43TPS@69541|Desulfuromonadales 28221|Deltaproteobacteria M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11,SdrD_B k59_1623218_1 1121438.JNJA01000005_gene1035 1.99e-16 84.0 COG0438@1|root,COG0438@2|Bacteria,1NTNW@1224|Proteobacteria,42Z8E@68525|delta/epsilon subdivisions,2WTUS@28221|Deltaproteobacteria,2M8UN@213115|Desulfovibrionales 28221|Deltaproteobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - k59_1466729_1 1121920.AUAU01000005_gene993 1.14e-25 105.0 COG0427@1|root,COG0427@2|Bacteria,3Y79K@57723|Acidobacteria 57723|Acidobacteria C Citrate lyase, alpha subunit (CitF) - - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_1258400_1 1343740.M271_05975 2.57e-29 114.0 COG1893@1|root,COG1893@2|Bacteria,2I3AM@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_1258400_2 991.IW20_11305 7.8e-24 94.4 COG0724@1|root,COG0724@2|Bacteria,4NT1J@976|Bacteroidetes,1I4VC@117743|Flavobacteriia,2NWBZ@237|Flavobacterium 976|Bacteroidetes S RNA recognition motif - - - - - - - - - - - - RRM_1 k59_1258400_3 857087.Metme_0971 1.29e-53 169.0 COG3461@1|root,COG3461@2|Bacteria,1MZZN@1224|Proteobacteria,1S688@1236|Gammaproteobacteria,1XFTT@135618|Methylococcales 135618|Methylococcales S Evidence 4 Homologs of previously reported genes of - - - ko:K09700 - - - - ko00000 - - - - k59_1258400_4 384765.SIAM614_25267 2.54e-26 103.0 COG2318@1|root,COG2318@2|Bacteria,1RD3M@1224|Proteobacteria,2U8HG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - DinB k59_735188_2 1278309.KB907099_gene2933 7.16e-25 105.0 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1QYEW@1224|Proteobacteria,1T3PI@1236|Gammaproteobacteria 1236|Gammaproteobacteria CO Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_5,Pyr_redox_3 k59_995956_3 1265490.JHVY01000027_gene474 1.5e-89 271.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,1RMH5@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the arginase family speB - 3.5.3.11,3.5.3.7,3.5.3.8 ko:K01479,ko:K01480,ko:K12255 ko00330,ko00340,ko01100,map00330,map00340,map01100 M00045,M00133 R01157,R01990,R02285 RC00024,RC00221,RC00329,RC00681 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_526155_1 228410.NE0350 4.32e-65 219.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,371V5@32003|Nitrosomonadales 28216|Betaproteobacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_631672_1 391625.PPSIR1_37229 6.25e-105 313.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42QAU@68525|delta/epsilon subdivisions,2WMD2@28221|Deltaproteobacteria,2YUNE@29|Myxococcales 28221|Deltaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - - ko:K11731 ko00281,map00281 - R08089 RC01893 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_683830_1 639282.DEFDS_2114 9.99e-131 394.0 COG0443@1|root,COG0443@2|Bacteria,2GEXS@200930|Deferribacteres 200930|Deferribacteres O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_839704_1 649638.Trad_0988 2.5e-118 354.0 COG0129@1|root,COG0129@2|Bacteria,1WIP6@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_1153373_1 1123320.KB889687_gene951 8.56e-134 403.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_892493_1 436308.Nmar_0043 1.69e-72 228.0 COG0392@1|root,arCOG00899@2157|Archaea,41SFV@651137|Thaumarchaeota 651137|Thaumarchaeota S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_689208_2 1335757.SPICUR_02975 3.51e-64 203.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,1WX1J@135613|Chromatiales 135613|Chromatiales I Enoyl- acyl-carrier-protein reductase NADH - - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_269619_1 1238182.C882_2434 1.14e-09 60.5 COG2010@1|root,COG2010@2|Bacteria,1MW1W@1224|Proteobacteria,2TVSN@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome C - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_269619_3 1229909.NSED_05375 1.78e-57 188.0 arCOG02703@1|root,arCOG02703@2157|Archaea 2157|Archaea S Methyltransferase type 11 - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 k59_269619_4 525904.Tter_1555 1.2e-51 173.0 COG1611@1|root,COG1611@2|Bacteria,2NP7M@2323|unclassified Bacteria 2|Bacteria S Possible lysine decarboxylase yvdD_2 - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_1627708_1 1123368.AUIS01000001_gene2062 6.16e-61 211.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2NDJD@225057|Acidithiobacillales 225057|Acidithiobacillales T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_4,Response_reg k59_426273_1 330214.NIDE1392 3.17e-49 175.0 COG0046@1|root,COG0046@2|Bacteria,3J0TJ@40117|Nitrospirae 40117|Nitrospirae F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,GATase_5 k59_162969_1 926560.KE387023_gene3327 8.71e-23 95.5 COG2062@1|root,COG2062@2|Bacteria,1WN47@1297|Deinococcus-Thermus 2|Bacteria T phosphohistidine phosphatase, SixA - - - - - - - - - - - - His_Phos_1 k59_1472217_1 880073.Calab_0228 5e-09 62.8 COG0457@1|root,COG4105@1|root,COG0457@2|Bacteria,COG4105@2|Bacteria 2|Bacteria S cell envelope organization bamD - - ko:K05807,ko:K08309 - - - - ko00000,ko01000,ko01011,ko02000 1.B.33.1 GH23 - TPR_16,TPR_6,YfiO k59_1053206_1 1089552.KI911559_gene301 5.34e-121 381.0 COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,2TRSY@28211|Alphaproteobacteria,2JPPS@204441|Rhodospirillales 204441|Rhodospirillales V ABC transporter transmembrane region - - - ko:K02021 - - - - ko00000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran,cNMP_binding k59_1053206_2 1168059.KB899087_gene3591 1.17e-09 61.2 COG0664@1|root,COG0664@2|Bacteria,1RDKD@1224|Proteobacteria,2UAYF@28211|Alphaproteobacteria,3F02G@335928|Xanthobacteraceae 28211|Alphaproteobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_637430_1 1234595.C725_0381 1.71e-63 208.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MVYW@1224|Proteobacteria,2TS8D@28211|Alphaproteobacteria,4BRUW@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Cupredoxin-like domain - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,Cytochrom_C,Cytochrome_CBB3 k59_1212046_1 331869.BAL199_30640 1.86e-124 378.0 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,4BR4G@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - ko:K06400 - - - - ko00000 - - - Recombinase,Resolvase,Zn_ribbon_recom k59_1105536_1 1179778.PMM47T1_12968 2.03e-95 287.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,1RMH5@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the arginase family speB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008783,GO:0009058,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0030145,GO:0034641,GO:0042401,GO:0043167,GO:0043169,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11,3.5.3.8 ko:K01479,ko:K01480 ko00330,ko00340,ko01100,map00330,map00340,map01100 M00045,M00133 R01157,R02285 RC00024,RC00221,RC00329,RC00681 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_02730,iECB_1328.ECB_02767,iECD_1391.ECD_02767,iSbBS512_1146.SbBS512_E3370 Arginase k59_112119_1 1114856.C496_20785 2.97e-21 94.0 COG1975@1|root,arCOG01929@2157|Archaea,2XVCW@28890|Euryarchaeota,23S20@183963|Halobacteria 183963|Halobacteria O COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family xdhC - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_162980_1 1232410.KI421415_gene2933 6.01e-111 358.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_530503_1 502025.Hoch_0991 8.42e-66 213.0 COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,4313Z@68525|delta/epsilon subdivisions,2WX2K@28221|Deltaproteobacteria,2Z2QP@29|Myxococcales 28221|Deltaproteobacteria L Integrase core domain - - - - - - - - - - - - rve k59_1053209_1 1188256.BASI01000002_gene3217 4.77e-08 55.1 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_1053209_2 402881.Plav_2793 3.51e-155 450.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,1JN80@119043|Rhodobiaceae 28211|Alphaproteobacteria C Belongs to the aldehyde dehydrogenase family gabD GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0032787,GO:0034641,GO:0042133,GO:0042135,GO:0042402,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0097164,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.2.1.16,1.2.1.20,1.2.1.24,1.2.1.79 ko:K00135,ko:K08324 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_269641_1 76114.ebA2038 1.23e-57 198.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VGZU@28216|Betaproteobacteria,2KY7I@206389|Rhodocyclales 1224|Proteobacteria I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1520453_1 1397528.Q671_03525 1.96e-54 183.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1XIWE@135619|Oceanospirillales 135619|Oceanospirillales E PFAM Cys Met metabolism - - 2.5.1.48,4.4.1.1 ko:K01739,ko:K01758 ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017,M00338 R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366 RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP k59_1520453_2 1232410.KI421421_gene3294 1.15e-08 56.2 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,43U1S@69541|Desulfuromonadales 28221|Deltaproteobacteria E Beta-eliminating lyase - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_1472248_1 330214.NIDE0200 3.78e-35 125.0 COG0793@1|root,COG0793@2|Bacteria 2|Bacteria M Belongs to the peptidase S41A family prc - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_1574869_1 330214.NIDE1392 5.41e-54 193.0 COG0046@1|root,COG0046@2|Bacteria,3J0TJ@40117|Nitrospirae 40117|Nitrospirae F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,GATase_5 k59_1264218_1 767817.Desgi_0419 3.65e-30 121.0 COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia 186801|Clostridia C aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_689255_1 399739.Pmen_4601 1.27e-11 62.8 COG2963@1|root,COG2963@2|Bacteria,1N28U@1224|Proteobacteria,1S9BK@1236|Gammaproteobacteria,1YKK5@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_426315_1 498211.CJA_1911 3.51e-31 127.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1FGBQ@10|Cellvibrio 1236|Gammaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_217311_1 411467.BACCAP_03646 7.94e-13 75.9 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,268G3@186813|unclassified Clostridiales 186801|Clostridia V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1053239_1 420324.KI911970_gene1564 3.27e-110 336.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1105572_1 472759.Nhal_1845 1.84e-78 260.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,LysM k59_163015_1 1121937.AUHJ01000011_gene2876 2.19e-20 95.1 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RZG3@1236|Gammaproteobacteria,466R7@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_844223_1 247633.GP2143_01100 5.1e-53 186.0 COG0642@1|root,COG2205@2|Bacteria,1QVQF@1224|Proteobacteria,1T2GZ@1236|Gammaproteobacteria,1JC0W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Signal transduction histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c k59_62937_1 228410.NE0622 6.19e-14 67.4 COG0662@1|root,COG0662@2|Bacteria,1RFTK@1224|Proteobacteria,2WG1F@28216|Betaproteobacteria,374QB@32003|Nitrosomonadales 28216|Betaproteobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 k59_62937_2 1304872.JAGC01000003_gene2560 4.19e-29 109.0 2C46F@1|root,32SRD@2|Bacteria,1N540@1224|Proteobacteria,42UJ6@68525|delta/epsilon subdivisions,2WQUS@28221|Deltaproteobacteria,2MBJ9@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1418687_1 1211815.CBYP010000063_gene1913 4.3e-137 404.0 COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria 201174|Actinobacteria I Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta - - - - - - - - - - - - Carboxyl_trans k59_1418687_2 1123247.AUIJ01000025_gene752 6.43e-70 232.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Acetyl propionyl-CoA carboxylase alpha subunit - - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_739490_1 56110.Oscil6304_3162 5.11e-13 75.5 COG1520@1|root,COG2304@1|root,COG4719@1|root,COG1520@2|Bacteria,COG2304@2|Bacteria,COG4719@2|Bacteria,1GQAT@1117|Cyanobacteria 1117|Cyanobacteria S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - k59_948021_1 269796.Rru_A1016 2.94e-109 325.0 COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2TSFD@28211|Alphaproteobacteria,2JQTE@204441|Rhodospirillales 204441|Rhodospirillales E Putrescine transport system permease potH - - ko:K11075 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - BPD_transp_1 k59_896624_1 1469245.JFBG01000014_gene2029 6.5e-224 624.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C acyl-CoA transferases carnitine dehydratase - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_896624_2 28444.JODQ01000008_gene970 2.23e-316 872.0 COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4EI6J@85012|Streptosporangiales 201174|Actinobacteria EH Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_896624_3 1380394.JADL01000005_gene5615 5.69e-86 261.0 COG1802@1|root,COG1802@2|Bacteria,1MXNF@1224|Proteobacteria,2U1PK@28211|Alphaproteobacteria,2JUZ9@204441|Rhodospirillales 204441|Rhodospirillales K FCD - - - - - - - - - - - - FCD,GntR k59_530550_1 1238182.C882_4011 7.58e-74 233.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,2JPIB@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1105589_1 865861.AZSU01000003_gene1719 5.14e-26 102.0 COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,24HWS@186801|Clostridia,36E62@31979|Clostridiaceae 186801|Clostridia J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_739495_2 1304885.AUEY01000041_gene3678 2.4e-13 69.3 COG1331@1|root,COG1331@2|Bacteria,1N55I@1224|Proteobacteria,42VTZ@68525|delta/epsilon subdivisions,2WQ84@28221|Deltaproteobacteria,2MPIU@213118|Desulfobacterales 28221|Deltaproteobacteria O Thioredoxin-like - - - - - - - - - - - - FKBP_C,Thioredoxin_7 k59_112180_1 479431.Namu_3835 8.27e-24 101.0 COG1695@1|root,COG1695@2|Bacteria,2IFDN@201174|Actinobacteria,4ET5U@85013|Frankiales 201174|Actinobacteria K Transcriptional regulator - - - - - - - - - - - - PadR k59_1264272_1 436308.Nmar_1383 6.66e-62 191.0 COG1460@1|root,arCOG01016@2157|Archaea,41SQ1@651137|Thaumarchaeota 651137|Thaumarchaeota K RNA polymerase Rpb4 - - 2.7.7.6 ko:K03051 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb4 k59_1264272_2 436308.Nmar_1384 5.82e-45 146.0 COG2139@1|root,arCOG04129@2157|Archaea,41SRF@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the eukaryotic ribosomal protein eL21 family rpl21e - - ko:K02889 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21e k59_1574917_1 268746.Q58M38_BPPRM 9.37e-27 101.0 4QCB4@10239|Viruses,4QVPP@35237|dsDNA viruses no RNA stage,4QQW0@28883|Caudovirales,4QI3R@10662|Myoviridae 10662|Myoviridae S Protein of unknown function (DUF2973) - - - - - - - - - - - - - k59_638384_2 867902.Ornrh_1452 7.75e-54 174.0 COG0588@1|root,COG0588@2|Bacteria,4NFP5@976|Bacteroidetes,1I215@117743|Flavobacteriia 976|Bacteroidetes G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmA GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_1000876_1 290512.Paes_1052 4.8e-08 57.0 COG0318@1|root,COG0318@2|Bacteria,1FDAB@1090|Chlorobi 1090|Chlorobi IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1000876_2 15368.BRADI1G14590.1 3.31e-08 55.5 COG0002@1|root,KOG4354@2759|Eukaryota,37R6A@33090|Viridiplantae,3G7HC@35493|Streptophyta,3KT4T@4447|Liliopsida,3I998@38820|Poales 35493|Streptophyta E N-acetyl-gamma-glutamyl-phosphate reductase - GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0010035,GO:0010038,GO:0016020,GO:0031974,GO:0031981,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046686,GO:0046872,GO:0046914,GO:0050896,GO:0070013 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_218048_1 330214.NIDE1460 1.78e-56 177.0 COG0316@1|root,COG0316@2|Bacteria,3J0TZ@40117|Nitrospirae 40117|Nitrospirae S Belongs to the HesB IscA family - - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_374892_2 1028800.RG540_CH13660 2.26e-28 112.0 COG3023@1|root,COG3023@2|Bacteria,1N032@1224|Proteobacteria,2U6P9@28211|Alphaproteobacteria,4BHDN@82115|Rhizobiaceae 28211|Alphaproteobacteria V N-acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - Amidase_2,PG_binding_1 k59_323163_1 395493.BegalDRAFT_3125 2.01e-102 309.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,1RPTT@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the binding-protein-dependent transport system permease family livM GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - iPC815.YPO3806,iSDY_1059.SDY_3605 BPD_transp_2,DUF3382 k59_1053954_1 556268.OFAG_00203 9.99e-41 149.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,2VIBP@28216|Betaproteobacteria,472TJ@75682|Oxalobacteraceae 28216|Betaproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_1265154_3 1434929.X946_5204 5.16e-52 170.0 COG1796@1|root,COG1796@2|Bacteria,1QF8Z@1224|Proteobacteria,2WASJ@28216|Betaproteobacteria,1K40Q@119060|Burkholderiaceae 28216|Betaproteobacteria L Helix-hairpin-helix domain - - - ko:K04477 - - - - ko00000 - - - HHH_5,HHH_8 k59_323164_1 481448.Minf_0214 8.57e-70 229.0 COG1034@1|root,COG3383@1|root,COG1034@2|Bacteria,COG3383@2|Bacteria,46S6S@74201|Verrucomicrobia,37G1Z@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3 k59_531274_1 1517416.IDAT_07270 3.45e-37 140.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,2QF1Q@267893|Idiomarinaceae 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944 - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_1575637_1 756272.Plabr_0919 2.26e-35 138.0 COG1409@1|root,COG1409@2|Bacteria,2J2TN@203682|Planctomycetes 203682|Planctomycetes S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_1473202_2 596151.DesfrDRAFT_3236 2.45e-73 236.0 COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,42QRA@68525|delta/epsilon subdivisions,2WN1V@28221|Deltaproteobacteria,2M9E5@213115|Desulfovibrionales 28221|Deltaproteobacteria S Beta-lactamase superfamily domain - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - Lactamase_B k59_1473202_4 1232437.KL662006_gene4388 6e-49 162.0 2C477@1|root,32RDF@2|Bacteria,1RKW1@1224|Proteobacteria,42SWN@68525|delta/epsilon subdivisions,2WP88@28221|Deltaproteobacteria 28221|Deltaproteobacteria S DGC domain - - - - - - - - - - - - DGC k59_740201_1 1380391.JIAS01000011_gene5426 7.21e-77 241.0 COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2TTX8@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG1960 Acyl-CoA dehydrogenases - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_844930_1 1435356.Y013_20190 6.84e-51 178.0 COG0204@1|root,COG0560@1|root,COG0204@2|Bacteria,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,4FUIH@85025|Nocardiaceae 201174|Actinobacteria EI Phosphate acyltransferases plsC - 2.3.1.51,3.1.3.3 ko:K00655,ko:K15781 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase,HAD k59_1314611_2 1125863.JAFN01000001_gene2325 4.31e-26 109.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_948759_1 765913.ThidrDRAFT_4263 1.92e-65 205.0 COG3153@1|root,COG3153@2|Bacteria,1R18E@1224|Proteobacteria,1S3BU@1236|Gammaproteobacteria,1WY6P@135613|Chromatiales 135613|Chromatiales S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_10 k59_948759_2 765912.Thimo_0396 2.87e-21 87.0 2E1AT@1|root,32WQS@2|Bacteria,1N2PK@1224|Proteobacteria,1SADT@1236|Gammaproteobacteria,1WYUU@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_795267_1 857087.Metme_2937 1.24e-106 320.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XFEP@135618|Methylococcales 135618|Methylococcales P Ammonium Transporter Family - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_1424122_1 1499967.BAYZ01000095_gene4149 3.56e-25 99.8 COG0071@1|root,COG0071@2|Bacteria,2NPWF@2323|unclassified Bacteria 2|Bacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_1424122_2 313612.L8106_09416 4.55e-43 154.0 COG0484@1|root,COG0484@2|Bacteria,1FZXU@1117|Cyanobacteria,1HA29@1150|Oscillatoriales 1117|Cyanobacteria O DnaJ C terminal domain - - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_68324_1 472759.Nhal_3447 5.53e-89 276.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1WXEF@135613|Chromatiales 135613|Chromatiales G Belongs to the pyruvate kinase family - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_1004692_1 1288826.MSNKSG1_05526 4.64e-26 108.0 COG3156@1|root,COG3156@2|Bacteria,1RBNV@1224|Proteobacteria,1S5US@1236|Gammaproteobacteria,46CQU@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG3156 Type II secretory pathway, component PulK xcpX - - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_799898_1 187272.Mlg_2618 4.53e-46 153.0 COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,1S61I@1236|Gammaproteobacteria,1WYB4@135613|Chromatiales 135613|Chromatiales J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd - - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_1632306_1 748247.AZKH_3967 2.68e-57 182.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2VR2Z@28216|Betaproteobacteria,2KWHT@206389|Rhodocyclales 206389|Rhodocyclales L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_167290_3 190486.XAC1064 1.66e-105 323.0 COG5410@1|root,COG5410@2|Bacteria,1N0W2@1224|Proteobacteria,1TCS2@1236|Gammaproteobacteria,1X9QW@135614|Xanthomonadales 135614|Xanthomonadales K chromosome segregation - - - - - - - - - - - - - k59_743692_1 519989.ECTPHS_03774 2.25e-82 259.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WX6V@135613|Chromatiales 135613|Chromatiales E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1160853_1 1415779.JOMH01000001_gene538 3.02e-77 239.0 COG0412@1|root,COG0412@2|Bacteria,1PSEB@1224|Proteobacteria,1RNZS@1236|Gammaproteobacteria,1X352@135614|Xanthomonadales 135614|Xanthomonadales Q Dienelactone hydrolase family - - - - - - - - - - - - DLH k59_693530_1 1123023.JIAI01000002_gene5532 3e-09 63.2 COG2114@1|root,COG2114@2|Bacteria,2GN02@201174|Actinobacteria,4E1TB@85010|Pseudonocardiales 201174|Actinobacteria T Adenylate cyclase regulatory domain cya - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Ad_Cy_reg,Guanylate_cyc k59_799921_1 243159.AFE_2681 6.68e-11 68.6 COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria,1S4C5@1236|Gammaproteobacteria 1236|Gammaproteobacteria M tpr domain protein - - - - - - - - - - - - DUF29,Glyco_transf_9,TPR_1,TPR_16,TPR_19,TPR_2,TPR_8 k59_5724_1 986075.CathTA2_2407 8.71e-23 100.0 COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,4H9KT@91061|Bacilli 91061|Bacilli M transferase tagO GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914 2.7.8.33,2.7.8.35 ko:K02851 - - R08856 RC00002 ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_4 k59_1632323_1 323261.Noc_3068 3.14e-47 171.0 COG0438@1|root,COG0438@2|Bacteria,1QZ01@1224|Proteobacteria,1RZJA@1236|Gammaproteobacteria,1X05E@135613|Chromatiales 135613|Chromatiales M sucrose synthase - - 2.4.1.13 ko:K00695 ko00500,ko01100,map00500,map01100 - R00806 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000,ko01003 - GT4 - Glycos_transf_1,Sucrose_synth k59_1370767_1 1089549.AZUQ01000001_gene2729 1.88e-20 89.7 COG1309@1|root,COG1309@2|Bacteria,2HMJ5@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - TetR_N k59_1370767_2 1304872.JAGC01000009_gene1527 1.02e-29 120.0 COG2067@1|root,COG2067@2|Bacteria,1RDE4@1224|Proteobacteria,42Y3S@68525|delta/epsilon subdivisions,2WY29@28221|Deltaproteobacteria,2MAMJ@213115|Desulfovibrionales 28221|Deltaproteobacteria I long-chain fatty acid transport protein - - - - - - - - - - - - - k59_1216542_1 522373.Smlt1622 3.74e-05 46.2 COG4967@1|root,COG4967@2|Bacteria 2|Bacteria NU type IV pilus modification protein PilV pilV - - ko:K02671 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_1216542_2 582744.Msip34_2597 2.14e-06 55.1 COG4970@1|root,COG4970@2|Bacteria,1NA9B@1224|Proteobacteria,2VWAB@28216|Betaproteobacteria,2KN37@206350|Nitrosomonadales 206350|Nitrosomonadales NU Type II transport protein GspH - - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_378680_1 204669.Acid345_3219 7.35e-32 133.0 COG0323@1|root,COG0323@2|Bacteria,3Y2T3@57723|Acidobacteria,2JI29@204432|Acidobacteriia 204432|Acidobacteriia L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_587179_1 95619.PM1_0216610 2.59e-46 162.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1RQ0H@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Threonine synthase thrC GO:0003674,GO:0003824,GO:0004795,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - iLF82_1304.LF82_2261,iNRG857_1313.NRG857_00025 PALP,Thr_synth_N k59_273925_1 1379698.RBG1_1C00001G1061 7.5e-85 265.0 COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria 2|Bacteria C NADH-quinone oxidoreductase, chain M nuoM-1 - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_430458_1 565045.NOR51B_2303 1.54e-108 320.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system ttcA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_1523301_2 1038859.AXAU01000029_gene78 7.14e-26 105.0 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2U7XT@28211|Alphaproteobacteria,3K02I@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H GTP cyclohydrolase I - - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_1109832_1 1514668.JOOA01000002_gene3257 1.05e-10 60.5 COG0236@1|root,COG0236@2|Bacteria,1VGGM@1239|Firmicutes,24Q2V@186801|Clostridia,3WKNG@541000|Ruminococcaceae 186801|Clostridia IQ Phosphopantetheine attachment site - - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_1370788_1 1121948.AUAC01000003_gene2510 8.05e-20 82.8 COG4327@1|root,COG4327@2|Bacteria,1N0TK@1224|Proteobacteria,2UC3P@28211|Alphaproteobacteria,43Y3N@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF4212) - - - - - - - - - - - - DUF4212 k59_1370788_2 479433.Caci_5356 7.03e-45 156.0 COG1960@1|root,COG1960@2|Bacteria,2ICK3@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_378698_1 1454004.AW11_01799 1.03e-11 65.5 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,1KQC7@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_378698_2 1123367.C666_13375 3.68e-39 132.0 COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2VU8W@28216|Betaproteobacteria,2KWVF@206389|Rhodocyclales 206389|Rhodocyclales G Phosphotransferase System ptsH - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr k59_378698_3 582744.Msip34_0198 1.22e-08 53.9 COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2VT9I@28216|Betaproteobacteria,2KMX4@206350|Nitrosomonadales 206350|Nitrosomonadales G PFAM PTS system fructose subfamily IIA component - - 2.7.1.194 ko:K02821 ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 M00283,M00550 R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.7.1 - - EIIA-man k59_430463_1 555500.I215_07087 7.11e-39 142.0 COG5421@1|root,COG5421@2|Bacteria,4PAGJ@976|Bacteroidetes,1IAIH@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - DDE_Tnp_1 k59_379433_2 629265.PMA4326_21192 1.23e-61 196.0 COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,1Z5W8@136849|Pseudomonas syringae group 1236|Gammaproteobacteria JM Nucleotidyl transferase - GO:0000166,GO:0000270,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006040,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019752,GO:0030203,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044281,GO:0046872,GO:0070569,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.7.13,2.7.7.99 ko:K00966,ko:K00992 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885,R11025 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_1161225_1 156889.Mmc1_0444 6.79e-26 108.0 COG1651@1|root,COG1651@2|Bacteria,1MX2T@1224|Proteobacteria 1224|Proteobacteria O DSBA oxidoreductase MA20_20720 - - - - - - - - - - - DSBA,Thioredoxin_4 k59_643773_1 317025.Tcr_0338 2.79e-187 531.0 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1RRMI@1236|Gammaproteobacteria,462ZC@72273|Thiotrichales 72273|Thiotrichales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1424929_1 392499.Swit_3254 1.12e-47 169.0 COG3391@1|root,COG3391@2|Bacteria,1R8X0@1224|Proteobacteria,2U257@28211|Alphaproteobacteria,2K2QA@204457|Sphingomonadales 204457|Sphingomonadales S Methylamine dehydrogenase heavy chain (MADH) - - 1.4.9.1 ko:K15229 ko00680,ko01120,map00680,map01120 - R00606 RC00189 ko00000,ko00001,ko01000 - - - Me-amine-dh_H k59_848798_1 1283300.ATXB01000001_gene40 1.49e-89 270.0 COG1611@1|root,COG1611@2|Bacteria,1R8EU@1224|Proteobacteria,1SKDD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S YHS domain - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - YHS k59_1270500_1 445686.E3SKU6_9CAUD 4.43e-43 161.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_379446_2 1123252.ATZF01000005_gene4108 8.2e-11 67.8 COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,4HEMP@91061|Bacilli,27BJ6@186824|Thermoactinomycetaceae 91061|Bacilli P MgtE intracellular N domain - - - - - - - - - - - - CBS,MgtE,MgtE_N k59_274347_1 380703.AHA_0548 3.95e-54 188.0 COG0025@1|root,COG1226@1|root,COG0025@2|Bacteria,COG1226@2|Bacteria,1QTUE@1224|Proteobacteria,1T1HJ@1236|Gammaproteobacteria,1Y6MG@135624|Aeromonadales 135624|Aeromonadales P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - - - - - - - - - - Na_H_Exchanger,TrkA_N k59_1523572_1 243233.MCA1567 1.55e-53 182.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1XEJX@135618|Methylococcales 135618|Methylococcales H MoeA N-terminal region (domain I - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_643785_1 326424.FRAAL3537 8.19e-76 240.0 COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria 201174|Actinobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_848806_1 8081.XP_008423351.1 7.83e-21 96.7 2CMBX@1|root,2QPXH@2759|Eukaryota,39R4Y@33154|Opisthokonta,3BEII@33208|Metazoa,3CUKT@33213|Bilateria,48C7J@7711|Chordata,49A3F@7742|Vertebrata,49W32@7898|Actinopterygii 33208|Metazoa S Zgc 172049 - - 2.7.1.43 ko:K16190 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014 R01476 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N,NTP_transferase k59_69156_1 395493.BegalDRAFT_0811 2.09e-89 273.0 COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,1RMH8@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC transporter (permease) yejB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0022857,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944 - ko:K13894 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - BPD_transp_1 k59_694046_1 247634.GPB2148_1795 1.49e-51 173.0 2F6IW@1|root,33Z1T@2|Bacteria,1NKX4@1224|Proteobacteria 1224|Proteobacteria S sterol desaturase - - - - - - - - - - - - FA_hydroxylase k59_694046_2 931627.MycrhDRAFT_1541 1.06e-15 82.0 COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,235XV@1762|Mycobacteriaceae 201174|Actinobacteria S amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_848808_1 95619.PM1_0204980 1.59e-25 103.0 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria 1236|Gammaproteobacteria L dna polymerase III delta subunit holA GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta k59_848808_2 497964.CfE428DRAFT_3347 3.68e-12 63.2 COG2835@1|root,COG2835@2|Bacteria 2|Bacteria EG tetraacyldisaccharide 4'-kinase activity - - - ko:K09791 - - - - ko00000 - - - Methyltransf_25,Trm112p k59_430810_1 76114.ebA2245 1.46e-120 361.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,2KVQ1@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_430813_1 1442599.JAAN01000045_gene2797 8.95e-59 205.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,1RSEQ@1236|Gammaproteobacteria,1X3DR@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_800828_1 1335757.SPICUR_03170 1.99e-59 188.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,1WY5U@135613|Chromatiales 135613|Chromatiales K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_800828_2 1026882.MAMP_00891 9.58e-20 89.4 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,45ZPA@72273|Thiotrichales 72273|Thiotrichales F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_1632747_1 1201290.M902_2199 6.04e-05 56.2 COG4932@1|root,COG4932@2|Bacteria 2|Bacteria M domain protein - - - - - - - - - - - - CHU_C,Flg_new,PKD,SprB k59_222161_1 479434.Sthe_2560 5.97e-23 95.1 COG0526@1|root,COG0526@2|Bacteria,2G72F@200795|Chloroflexi,27YHJ@189775|Thermomicrobia 189775|Thermomicrobia CO alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA k59_1216861_2 519989.ECTPHS_11687 1.89e-99 295.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,1WXK5@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K07660 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_800839_1 649638.Trad_0654 1.36e-73 234.0 COG0183@1|root,COG0183@2|Bacteria,1WIPU@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I Belongs to the thiolase family - - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1424973_1 765914.ThisiDRAFT_0954 1.65e-59 201.0 COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,1WX9B@135613|Chromatiales 135613|Chromatiales E Belongs to the acetyltransferase family. ArgA subfamily argA - 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Acetyltransf_1 k59_535268_1 926569.ANT_12500 0.000923 41.6 COG0517@1|root,COG0517@2|Bacteria,2G6TI@200795|Chloroflexi 2|Bacteria S amino acid-binding ACT domain protein - - - - - - - - - - - - CBS,GGDEF k59_694062_1 1122194.AUHU01000004_gene1313 4.2e-24 103.0 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,1RRDQ@1236|Gammaproteobacteria,46495@72275|Alteromonadaceae 1236|Gammaproteobacteria V COG0534 Na -driven multidrug efflux pump - - - - - - - - - - - - MatE k59_694062_2 667632.KB890170_gene3621 6.21e-58 186.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2VJVA@28216|Betaproteobacteria,1K0P4@119060|Burkholderiaceae 28216|Betaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family paaF - 4.2.1.17 ko:K01692,ko:K01715 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_222167_1 462590.A9J587_BPPYU 3.48e-20 87.4 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0005575,GO:0019012,GO:0019028,GO:0032991,GO:0044423,GO:0046806 - - - - - - - - - - - k59_430824_1 370438.PTH_1626 2.3e-39 143.0 COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,2600U@186807|Peptococcaceae 186801|Clostridia F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_6211_1 1449063.JMLS01000002_gene1150 5.8e-43 145.0 COG2077@1|root,COG2077@2|Bacteria,1V474@1239|Firmicutes,4HFMW@91061|Bacilli,26RRH@186822|Paenibacillaceae 91061|Bacilli O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - AhpC-TSA,Redoxin k59_6211_2 398767.Glov_3186 1.23e-30 108.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WQ3M@28221|Deltaproteobacteria 28221|Deltaproteobacteria K cold-shock protein cspD - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_379495_1 1173029.JH980292_gene1295 1.69e-71 228.0 COG0598@1|root,COG0598@2|Bacteria,1G1AG@1117|Cyanobacteria,1H99G@1150|Oscillatoriales 1117|Cyanobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_694066_1 1255043.TVNIR_2243 6.74e-67 214.0 COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,1RQI4@1236|Gammaproteobacteria,1WVY9@135613|Chromatiales 135613|Chromatiales S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase k59_694066_2 626887.J057_16230 0.000113 44.3 COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,1RR44@1236|Gammaproteobacteria,466C6@72275|Alteromonadaceae 1236|Gammaproteobacteria S Histidine-specific methyltransferase, SAM-dependent egtD - 2.1.1.44 ko:K18911 ko00340,map00340 - R01169 RC00003,RC02308 ko00000,ko00001,ko01000 - - - Methyltransf_33 k59_327148_1 1229909.NSED_03210 6.37e-66 211.0 arCOG08741@1|root,arCOG08741@2157|Archaea,41SWQ@651137|Thaumarchaeota 651137|Thaumarchaeota E CAAX protease self-immunity - - - - - - - - - - - - Abi k59_1270553_2 426716.JOAJ01000003_gene3786 3.46e-92 278.0 COG4221@1|root,COG4221@2|Bacteria,2I3PD@201174|Actinobacteria,4G9PJ@85025|Nocardiaceae 201174|Actinobacteria S Enoyl-(Acyl carrier protein) reductase - - 1.1.1.53 ko:K00038 ko00140,ko01100,map00140,map01100 - R04831,R04834,R04844,R04847 RC00139,RC01219,RC01220 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_535276_2 1048834.TC41_1649 4.33e-31 120.0 COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,277XE@186823|Alicyclobacillaceae 91061|Bacilli D Tyrosine recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_226208_1 1187851.A33M_4208 2.82e-220 620.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,3FCY5@34008|Rhodovulum 28211|Alphaproteobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2 k59_1277239_2 483215.BACFIN_08407 3.58e-26 100.0 COG0614@1|root,COG0614@2|Bacteria,4NRGG@976|Bacteroidetes,2FT59@200643|Bacteroidia,4AREE@815|Bacteroidaceae 976|Bacteroidetes P PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_3 k59_1277239_3 326297.Sama_2235 5.25e-17 79.7 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,2Q8KK@267890|Shewanellaceae 1236|Gammaproteobacteria M PFAM NAD-dependent epimerase dehydratase - - 5.1.3.25,5.1.3.6 ko:K08679,ko:K17947 ko00520,ko00523,ko01100,ko01130,map00520,map00523,map01100,map01130 - R01385,R10279 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_1527142_1 1719.CPTC_00286 1.07e-10 58.2 COG1841@1|root,COG1841@2|Bacteria,2GQV0@201174|Actinobacteria,22P8I@1653|Corynebacteriaceae 201174|Actinobacteria J Ribosomal protein L30 rpmD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_1527142_2 439292.Bsel_0132 2.35e-23 94.4 COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,4HFN4@91061|Bacilli,26NPT@186821|Sporolactobacillaceae 91061|Bacilli J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_957706_1 880073.Calab_1147 1.03e-47 157.0 COG0720@1|root,COG0720@2|Bacteria,2NR5B@2323|unclassified Bacteria 2|Bacteria H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_957706_2 1191523.MROS_1984 4.53e-13 65.9 COG0720@1|root,COG0720@2|Bacteria 2|Bacteria H synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_1431322_2 1198232.CYCME_0821 6.54e-57 185.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,45ZN2@72273|Thiotrichales 72273|Thiotrichales Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_332236_1 693986.MOC_1019 1.72e-58 201.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TQMV@28211|Alphaproteobacteria,1JQQW@119045|Methylobacteriaceae 28211|Alphaproteobacteria G PQQ-like domain - - - - - - - - - - - - PQQ,PQQ_2,PQQ_3 k59_1222706_1 984262.SGRA_3600 9.18e-54 178.0 COG1089@1|root,COG1089@2|Bacteria,4NEB6@976|Bacteroidetes,1IQAV@117747|Sphingobacteriia 976|Bacteroidetes M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_1222706_2 1123276.KB893245_gene1252 5.26e-17 81.3 COG1087@1|root,COG1087@2|Bacteria,4NEM9@976|Bacteroidetes,47JM5@768503|Cytophagia 976|Bacteroidetes M PFAM NAD dependent epimerase dehydratase family galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_540102_1 1123073.KB899242_gene1358 4.08e-49 166.0 COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,1RP85@1236|Gammaproteobacteria,1X52R@135614|Xanthomonadales 135614|Xanthomonadales I enoyl-CoA hydratase - - 4.2.1.18 ko:K13766 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_279790_1 445686.E3SL91_9CAUD 4.92e-37 137.0 4QCGC@10239|Viruses,4QZFA@35237|dsDNA viruses no RNA stage,4QTZH@28883|Caudovirales,4QJ8J@10662|Myoviridae 10662|Myoviridae S Domain of unknown function (DUF4338) - - - - - - - - - - - - - k59_279790_2 445696.E3SSZ1_9CAUD 4.12e-12 62.4 4QAZ9@10239|Viruses,4QXZS@35237|dsDNA viruses no RNA stage,4QRUZ@28883|Caudovirales,4QK3Q@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_123823_2 414684.RC1_0800 1.88e-83 264.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,2TU50@28211|Alphaproteobacteria,2JSBB@204441|Rhodospirillales 204441|Rhodospirillales U MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_699135_1 765910.MARPU_02560 2.27e-76 246.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales 135613|Chromatiales U sulphate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_1376076_1 1167006.UWK_01967 4.62e-34 129.0 28I4Q@1|root,2Z886@2|Bacteria,1R41F@1224|Proteobacteria,42U62@68525|delta/epsilon subdivisions,2WQUC@28221|Deltaproteobacteria,2MNHB@213118|Desulfobacterales 28221|Deltaproteobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_1010361_1 880072.Desac_2908 1.36e-34 135.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2MQ7V@213462|Syntrophobacterales 28221|Deltaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_279802_1 1229520.ADIAL_0699 2.94e-21 94.4 COG0471@1|root,COG0471@2|Bacteria,1W70N@1239|Firmicutes,4IESN@91061|Bacilli,27HKN@186828|Carnobacteriaceae 91061|Bacilli P Sodium:sulfate symporter transmembrane region - - - - - - - - - - - - Na_sulph_symp k59_279802_2 998674.ATTE01000001_gene182 2.08e-125 376.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,45ZNP@72273|Thiotrichales 72273|Thiotrichales T GTP-binding protein TypA - - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_1485001_1 945713.IALB_1902 2.91e-88 270.0 COG0226@1|root,COG0226@2|Bacteria 2|Bacteria P phosphate ion binding pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_1527167_1 925409.KI911562_gene1835 1.19e-79 251.0 COG0334@1|root,COG0334@2|Bacteria,4NEBH@976|Bacteroidetes,1IPRA@117747|Sphingobacteriia 976|Bacteroidetes E Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_1115332_1 1158182.KB905022_gene857 4.37e-36 139.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1X0DP@135613|Chromatiales 135613|Chromatiales G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_1115332_2 1265313.HRUBRA_02554 3.02e-06 48.5 COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,1RQID@1236|Gammaproteobacteria,1J956@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S membrane - - - - - - - - - - - - DUF1295 k59_1010379_1 335992.SAR11_1361 6.04e-84 264.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2VFEC@28211|Alphaproteobacteria,4BQWR@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_807439_1 251229.Chro_0876 9.1e-80 260.0 COG1216@1|root,COG3250@1|root,COG1216@2|Bacteria,COG3250@2|Bacteria,1G2MT@1117|Cyanobacteria,3VNJZ@52604|Pleurocapsales 1117|Cyanobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glyco_hydro_2_C,Glycos_transf_2 k59_8244_2 743721.Psesu_0063 1.55e-52 175.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,1RTDE@1236|Gammaproteobacteria,1X5AI@135614|Xanthomonadales 135614|Xanthomonadales K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form cobB - - - - - - - - - - - SIR2 k59_1321658_1 305900.GV64_07580 8.34e-15 80.5 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1XHD2@135619|Oceanospirillales 135619|Oceanospirillales M Peptidase M23 - - - - - - - - - - - - OapA,Peptidase_M23 k59_957746_1 291112.PAU_02476 4.43e-45 156.0 COG0500@1|root,COG2226@2|Bacteria,1MV4M@1224|Proteobacteria,1RMWY@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM) cmoA GO:0002097,GO:0002098,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 - ko:K15256 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_25 k59_854079_1 1242864.D187_005763 4.04e-79 251.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Heat shock 70 kDa protein - - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_592698_1 765911.Thivi_4487 6.27e-73 244.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1WW7V@135613|Chromatiales 135613|Chromatiales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1063443_1 1219035.NT2_01_05660 5.43e-08 60.1 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2K0PV@204457|Sphingomonadales 204457|Sphingomonadales C dehydratase - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_491416_1 1122603.ATVI01000012_gene1131 1.99e-48 172.0 COG1231@1|root,COG1231@2|Bacteria,1MWPH@1224|Proteobacteria,1RPNY@1236|Gammaproteobacteria,1X5AK@135614|Xanthomonadales 135614|Xanthomonadales E Monoamine oxidase - - 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_75689_1 1232410.KI421425_gene1552 1.88e-75 253.0 COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales 28221|Deltaproteobacteria M OmpA family - - - - - - - - - - - - OmpA k59_1222754_1 671143.DAMO_2342 5.81e-89 286.0 COG0178@1|root,COG0178@2|Bacteria,2NNT3@2323|unclassified Bacteria 2|Bacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_592700_1 911045.PSE_0780 7.75e-09 56.6 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TYVX@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0604 NADPH quinone reductase and related Zn-dependent - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_650342_1 1125863.JAFN01000001_gene2969 1.77e-96 298.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU PFAM Type II secretion system protein E gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1222758_1 484770.UFO1_4522 1.3e-10 62.4 COG0517@1|root,COG0517@2|Bacteria,1V0XU@1239|Firmicutes,4H33K@909932|Negativicutes 909932|Negativicutes S CBS domain acuB - - ko:K04767 - - - - ko00000 - - - ACT,CBS k59_491426_2 1122599.AUGR01000012_gene901 1.22e-52 173.0 arCOG03638@1|root,2Z7NN@2|Bacteria,1R3Y6@1224|Proteobacteria,1RTWY@1236|Gammaproteobacteria,1XIZW@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_1376110_1 1283284.AZUK01000001_gene977 5.71e-06 47.4 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1Y3KP@135624|Aeromonadales 135624|Aeromonadales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_1376110_2 1121405.dsmv_2683 1.71e-05 49.3 28H91@1|root,2Z7KU@2|Bacteria,1R4NB@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_436757_2 28072.Nos7524_2763 1.81e-12 67.4 COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1GC0N@1117|Cyanobacteria,1HR0M@1161|Nostocales 1117|Cyanobacteria S Belongs to the peptidase M50B family - - - - - - - - - - - - CBS,Peptidase_M50 k59_699172_1 640511.BC1002_5497 9.66e-15 75.1 COG0457@1|root,COG0457@2|Bacteria,1N4HS@1224|Proteobacteria,2VMAM@28216|Betaproteobacteria,1K5Q1@119060|Burkholderiaceae 28216|Betaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_17,TPR_7,TPR_8 k59_699172_2 861299.J421_5988 1.86e-14 73.9 COG1273@1|root,COG1273@2|Bacteria 2|Bacteria M With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD ku - - ko:K10979 ko03450,map03450 - - - ko00000,ko00001,ko03400 - - - Ku k59_123884_1 1131553.JIBI01000009_gene1247 3.51e-105 310.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,2VJZS@28216|Betaproteobacteria 28216|Betaproteobacteria HJ Belongs to the RimK family rimK - - - - - - - - - - - RimK k59_957757_1 1265313.HRUBRA_00218 3.01e-175 503.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,1RQAM@1236|Gammaproteobacteria,1J4HJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Peptidase dimerisation domain - - - ko:K01436 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_906531_1 240015.ACP_0337 7.38e-82 261.0 COG3046@1|root,COG3046@2|Bacteria,3Y47V@57723|Acidobacteria,2JJ03@204432|Acidobacteriia 204432|Acidobacteriia S Deoxyribodipyrimidine photo-lyase-related protein - - - ko:K06876 - - - - ko00000 - - - DPRP,FAD_binding_7 k59_386199_1 756272.Plabr_3531 2.83e-31 122.0 COG0141@1|root,COG0141@2|Bacteria,2IXQ3@203682|Planctomycetes 203682|Planctomycetes E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_386199_2 1410628.JNKS01000005_gene1208 8.8e-34 122.0 COG0131@1|root,COG0131@2|Bacteria,1TRH7@1239|Firmicutes,247WC@186801|Clostridia,27JWB@186928|unclassified Lachnospiraceae 186801|Clostridia E Imidazoleglycerol-phosphate dehydratase hisB - 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD k59_1115366_1 518766.Rmar_1698 5.97e-48 172.0 COG0466@1|root,COG0466@2|Bacteria,4NE1G@976|Bacteroidetes,1FJX3@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes O Found in ATP-dependent protease La (LON) lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1321676_2 384765.SIAM614_01619 2.89e-74 238.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_172362_1 1163617.SCD_n02298 2.65e-46 168.0 COG2804@1|root,COG3437@1|root,COG2804@2|Bacteria,COG3437@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria 28216|Betaproteobacteria NU type II secretion system protein E - - - ko:K02454,ko:K02652,ko:K12276 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - Response_reg,T2SSE,T2SSE_N k59_807485_1 485915.Dret_1581 9.52e-43 150.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,42SR7@68525|delta/epsilon subdivisions,2WP65@28221|Deltaproteobacteria,2MBIV@213115|Desulfovibrionales 28221|Deltaproteobacteria D PFAM Maf family protein maf - - ko:K06287 - - - - ko00000 - - - Maf k59_807488_1 558152.IQ37_02135 0.000214 48.5 COG3666@1|root,COG3666@2|Bacteria,4NEDD@976|Bacteroidetes,1I0PW@117743|Flavobacteriia,3ZSET@59732|Chryseobacterium 976|Bacteroidetes L Transposase domain (DUF772) - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_491458_1 1150599.MPHLEI_00692 5.7e-68 223.0 COG4548@1|root,COG4548@2|Bacteria,2GIYK@201174|Actinobacteria,234RV@1762|Mycobacteriaceae 201174|Actinobacteria P von willebrand factor type a - - - - - - - - - - - - VWA,VWA_2,VWA_CoxE k59_854120_1 1049564.TevJSym_at00190 5.11e-66 205.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,1J5X0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_1485069_1 1254432.SCE1572_15020 3.43e-41 155.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,42M5P@68525|delta/epsilon subdivisions,2WIW8@28221|Deltaproteobacteria,2YUB7@29|Myxococcales 28221|Deltaproteobacteria KL Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_75742_1 405948.SACE_5396 5.62e-30 115.0 2DMDM@1|root,32Q85@2|Bacteria,2I484@201174|Actinobacteria,4EDPF@85010|Pseudonocardiales 201174|Actinobacteria S RES - - - - - - - - - - - - RES k59_699206_1 314278.NB231_11744 1.14e-13 71.6 COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,1RZ44@1236|Gammaproteobacteria 1236|Gammaproteobacteria N OmpA MotB - - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - OmpA k59_699206_2 1380394.JADL01000003_gene5023 3.73e-14 73.9 COG1511@1|root,COG1511@2|Bacteria,1NYJB@1224|Proteobacteria,2TSX0@28211|Alphaproteobacteria,2JPFY@204441|Rhodospirillales 204441|Rhodospirillales S MotA TolQ ExbB proton channel family - - - - - - - - - - - - - k59_436802_1 383372.Rcas_2300 2.94e-103 306.0 COG1878@1|root,COG1878@2|Bacteria,2G6VY@200795|Chloroflexi,3777F@32061|Chloroflexia 32061|Chloroflexia S Putative cyclase - - - - - - - - - - - - Cyclase k59_1277363_1 153948.NAL212_2341 1.93e-14 68.6 2E7GT@1|root,331ZH@2|Bacteria,1NAHD@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1277363_3 948071.S4S2D9_9CAUD 1.21e-23 100.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QNQ6@10744|Podoviridae 10744|Podoviridae S ribonucleoside-triphosphate reductase activity - - - - - - - - - - - - - k59_386244_1 1278073.MYSTI_00047 8.48e-79 248.0 COG3386@1|root,COG3386@2|Bacteria,1NIN4@1224|Proteobacteria 1224|Proteobacteria G Major royal jelly protein - - - - - - - - - - - - MRJP k59_279873_1 671143.DAMO_0457 4.96e-119 356.0 COG1029@1|root,COG1029@2|Bacteria 2|Bacteria - - fhcB GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0044237,GO:0044281 1.2.7.12 ko:K00201 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Molybdopterin k59_1431460_1 1229909.NSED_08810 5e-47 158.0 COG1422@1|root,arCOG02673@2157|Archaea,41SNR@651137|Thaumarchaeota 651137|Thaumarchaeota U membrane - - - - - - - - - - - - DUF106 k59_1376162_1 330214.NIDE2930 8.34e-25 101.0 COG1230@1|root,COG1230@2|Bacteria,3J11Z@40117|Nitrospirae 40117|Nitrospirae P Cation efflux family - - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux k59_1376162_2 330214.NIDE2933 2.08e-47 160.0 COG0523@1|root,COG0523@2|Bacteria 2|Bacteria P cobalamin synthesis protein COBW1 - - - - - - - - - - - CobW_C,cobW k59_749334_2 43989.cce_4500 1.67e-53 173.0 COG0454@1|root,COG0456@2|Bacteria,1G8NU@1117|Cyanobacteria,3KJV3@43988|Cyanothece 1117|Cyanobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_1431479_1 330214.NIDE1143 1.03e-36 129.0 COG2041@1|root,COG2041@2|Bacteria 2|Bacteria V Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide yuiH - - - - - - - - - - - Oxidored_molyb k59_1431479_2 234267.Acid_0524 4.2e-21 95.1 COG1651@1|root,COG1651@2|Bacteria 2|Bacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - - - - - - - - - - Thioredoxin_4 k59_436842_1 305900.GV64_14300 5.75e-20 87.8 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1XH86@135619|Oceanospirillales 135619|Oceanospirillales O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_436847_1 646529.Desaci_3566 4.03e-40 145.0 COG1206@1|root,COG1206@2|Bacteria,1TP67@1239|Firmicutes,24971@186801|Clostridia,260G4@186807|Peptococcaceae 186801|Clostridia J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs trmFO - 2.1.1.74 ko:K04094 - - - - ko00000,ko01000,ko03016,ko03036 - - - GIDA k59_386284_2 444860.E3SIT8_9CAUD 4.88e-31 109.0 4QBEG@10239|Viruses,4QW97@35237|dsDNA viruses no RNA stage,4QTIF@28883|Caudovirales,4QKJ5@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_501789_2 1380394.JADL01000008_gene3679 1.1e-55 182.0 COG2030@1|root,COG2030@2|Bacteria,1MUR2@1224|Proteobacteria,2TUM7@28211|Alphaproteobacteria,2JRMA@204441|Rhodospirillales 204441|Rhodospirillales I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydrat_N,MaoC_dehydratas k59_501791_1 718252.FP2_12470 2.5e-68 227.0 COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,3WGP7@541000|Ruminococcaceae 186801|Clostridia L Belongs to the DEAD box helicase family rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_1592636_1 518766.Rmar_0806 1.28e-133 390.0 COG0113@1|root,COG0113@2|Bacteria,4NFW6@976|Bacteroidetes,1FJ2J@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Delta-aminolevulinic acid dehydratase hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_1592636_2 1142394.PSMK_15220 3.41e-131 392.0 COG0143@1|root,COG0143@2|Bacteria,2IXD4@203682|Planctomycetes 203682|Planctomycetes J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_11921_1 314270.RB2083_918 4.02e-48 164.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,3ZI2P@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria L L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_287511_3 87626.PTD2_16361 3.34e-10 56.6 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,1S9DN@1236|Gammaproteobacteria,2Q2RP@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria O COG0760 Parvulin-like peptidyl-prolyl isomerase ppiC - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3 k59_1327569_1 1178482.BJB45_04915 8.99e-15 77.0 COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,1RMCH@1236|Gammaproteobacteria,1XIZQ@135619|Oceanospirillales 135619|Oceanospirillales G ABC transporter - - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran k59_287515_2 426117.M446_2719 2.17e-18 82.8 COG0664@1|root,COG0664@2|Bacteria,1RI6M@1224|Proteobacteria,2U9WH@28211|Alphaproteobacteria,1JUUA@119045|Methylobacteriaceae 28211|Alphaproteobacteria T PFAM Cyclic nucleotide-binding - - - - - - - - - - - - cNMP_binding k59_1441493_1 1229909.NSED_09505 5.78e-28 108.0 COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota 651137|Thaumarchaeota F Ribose-phosphate pyrophosphokinase - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran,Pribosyltran_N k59_1441493_2 1229909.NSED_09510 6.48e-55 181.0 COG1041@1|root,arCOG00047@2157|Archaea 2157|Archaea L RNA methylase trmG10 GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004809,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363 2.1.1.213 ko:K07446 - - - - ko00000,ko01000,ko03016 - - - THUMP,UPF0020 k59_706527_1 332101.JIBU02000023_gene4633 1.68e-28 119.0 COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,36DEW@31979|Clostridiaceae 186801|Clostridia L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity polC - 2.7.7.7 ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon k59_1071022_1 1054213.HMPREF9946_00179 3.86e-49 170.0 COG0477@1|root,COG2814@2|Bacteria,1R7EW@1224|Proteobacteria,2TXMM@28211|Alphaproteobacteria,2JW1M@204441|Rhodospirillales 204441|Rhodospirillales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_85955_1 1463885.KL578401_gene7402 1.8e-143 417.0 COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria 201174|Actinobacteria C PFAM FAD linked oxidase domain protein - - - - - - - - - - - - BBE,FAD_binding_4 k59_393064_1 977880.RALTA_A2814 1.9e-92 285.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,1K24M@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23,OmpA k59_861844_1 745310.G432_17825 7.24e-22 89.7 COG0346@1|root,COG0346@2|Bacteria,1RHD4@1224|Proteobacteria,2UCUY@28211|Alphaproteobacteria,2K4NH@204457|Sphingomonadales 204457|Sphingomonadales E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_861844_2 247634.GPB2148_96 8.02e-26 107.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria,1SMN0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1287760_1 1498011.A0A096XUX6_9CAUD 2.52e-112 372.0 4QCZC@10239|Viruses,4QRH3@28883|Caudovirales 28883|Caudovirales S Bacterial DNA polymerase III alpha subunit - - - - - - - - - - - - - k59_914334_2 649349.Lbys_2207 2.33e-07 52.0 COG1770@1|root,COG1770@2|Bacteria,4NEQS@976|Bacteroidetes,47KWW@768503|Cytophagia 976|Bacteroidetes E PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain ptrB - 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_1533121_1 562970.Btus_0709 3.17e-84 265.0 COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,4H9MX@91061|Bacilli,277WD@186823|Alicyclobacillaceae 91061|Bacilli E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_1533121_2 879243.Poras_1410 2.22e-40 138.0 COG0509@1|root,COG0509@2|Bacteria,4NQ35@976|Bacteroidetes,2FT3J@200643|Bacteroidia,22Y67@171551|Porphyromonadaceae 976|Bacteroidetes E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H k59_1533121_3 1122613.ATUP01000001_gene2187 3.26e-08 54.3 COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,2TR6C@28211|Alphaproteobacteria,43X9Y@69657|Hyphomonadaceae 28211|Alphaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_914342_1 159087.Daro_2582 4.45e-58 188.0 COG0737@1|root,COG0737@2|Bacteria,1RFNB@1224|Proteobacteria,2VR8M@28216|Betaproteobacteria,2KY2Y@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554 k59_1382970_1 1535422.ND16A_2150 1.11e-21 98.2 COG3485@1|root,COG4932@1|root,COG5276@1|root,COG3485@2|Bacteria,COG4932@2|Bacteria,COG5276@2|Bacteria,1QUEG@1224|Proteobacteria 1224|Proteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,CarboxypepD_reg,DUF11,FG-GAP k59_914344_1 693986.MOC_4714 9.58e-29 105.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2U9AQ@28211|Alphaproteobacteria,1JXZQ@119045|Methylobacteriaceae 28211|Alphaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_660706_1 1123242.JH636435_gene2162 1.65e-47 174.0 COG0616@1|root,COG0616@2|Bacteria,2IXFS@203682|Planctomycetes 203682|Planctomycetes OU Peptidase family S49 - - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_1122956_1 443152.MDG893_07955 6.12e-101 324.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,4645X@72275|Alteromonadaceae 1236|Gammaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1533133_1 945713.IALB_2101 2.22e-125 366.0 COG0074@1|root,COG0074@2|Bacteria 2|Bacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_287548_1 1182590.BN5_02893 3.55e-58 195.0 COG1704@1|root,COG1704@2|Bacteria,1RDUH@1224|Proteobacteria,1S2KR@1236|Gammaproteobacteria,1YHK2@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S E3 Ubiquitin ligase - - - - - - - - - - - - GIDE k59_861870_1 713587.THITH_14930 2.92e-95 290.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,1X0VD@135613|Chromatiales 135613|Chromatiales F Belongs to the dGTPase family. Type 2 subfamily - - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_817864_1 375286.mma_2407 0.000363 48.9 COG5164@1|root,COG5164@2|Bacteria,1MX1Z@1224|Proteobacteria,2VKEC@28216|Betaproteobacteria 28216|Betaproteobacteria K regulation of DNA-templated transcription, elongation - - - - - - - - - - - - - k59_1327620_1 686340.Metal_0101 6.86e-110 333.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1XDMC@135618|Methylococcales 1236|Gammaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_287562_1 314270.RB2083_1823 0.000183 48.9 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,3ZGW5@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria I carboxylase, alpha subunit mccA - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_756853_1 571.MC52_21980 1.14e-17 84.3 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,1RMX1@1236|Gammaproteobacteria 1236|Gammaproteobacteria E (ABC) transporter gluA - 3.6.3.21 ko:K02028,ko:K02029,ko:K10004,ko:K10010,ko:K10038,ko:K16960 ko02010,ko02020,map02010,map02020 M00227,M00230,M00234,M00236,M00585 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.10,3.A.1.3.13,3.A.1.3.14,3.A.1.3.19,3.A.1.3.2,3.A.1.3.4 - - ABC_tran,BPD_transp_1 k59_660746_1 317619.ANKN01000230_gene216 9.95e-33 122.0 COG3001@1|root,COG3001@2|Bacteria,1G040@1117|Cyanobacteria,1MM08@1212|Prochloraceae 1117|Cyanobacteria G Ribulosamine erythrulosamine 3-kinase potentially involved in protein deglycation - GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 - - - - - - - - - - Fructosamin_kin k59_660746_2 595537.Varpa_3406 9.03e-26 108.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,4AARI@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1533152_2 1589733.A0A0C5AIT8_9CAUD 7.66e-39 138.0 4QAQQ@10239|Viruses,4QPBX@28883|Caudovirales,4QIBM@10662|Myoviridae 10662|Myoviridae S T4-like virus tail tube protein gp19 - - - - - - - - - - - - - k59_817879_1 292415.Tbd_0889 8.36e-36 132.0 COG4398@1|root,COG4398@2|Bacteria,1MUX9@1224|Proteobacteria,2VIY7@28216|Betaproteobacteria 28216|Betaproteobacteria S FIST N domain - - - - - - - - - - - - FIST,FIST_C k59_1071075_1 395961.Cyan7425_2538 2.76e-28 114.0 COG0002@1|root,COG0002@2|Bacteria,1G0UX@1117|Cyanobacteria,3KGTV@43988|Cyanothece 1117|Cyanobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_132921_1 1049564.TevJSym_ab01790 3.36e-87 271.0 COG0265@1|root,COG3016@1|root,COG0265@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,1RPWZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Iron-regulated protein - - - - - - - - - - - - Cofac_haem_bdg,PDZ_2 k59_501906_1 420324.KI912006_gene8659 1.04e-17 81.6 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,1JTBI@119045|Methylobacteriaceae 28211|Alphaproteobacteria C PFAM biotin lipoyl attachment domain-containing protein lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_501906_2 10141.ENSCPOP00000007740 1.99e-52 179.0 COG0596@1|root,KOG2382@2759|Eukaryota,KOG4178@2759|Eukaryota,39UJH@33154|Opisthokonta,3BHQ0@33208|Metazoa,3CX97@33213|Bilateria,4895K@7711|Chordata,48YTE@7742|Vertebrata,3JCH1@40674|Mammalia,35PD4@314146|Euarchontoglires,4Q23F@9989|Rodentia 33208|Metazoa S Alpha beta hydrolase domain-containing protein 11 ABHD11 GO:0003674,GO:0003824,GO:0016787 - ko:K13703 - - - - ko00000,ko01002 - - - Abhydrolase_1,Abhydrolase_6 k59_501907_1 996637.SGM_0895 3.48e-09 54.3 2DEB4@1|root,2ZM7Z@2|Bacteria,2GQVF@201174|Actinobacteria 201174|Actinobacteria S Helix-turn-helix domain - - - - - - - - - - - - HTH_17 k59_707410_1 713586.KB900536_gene2639 1.81e-24 101.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1WX43@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_707410_2 1049564.TevJSym_by00060 5.66e-43 143.0 2E7PJ@1|root,33255@2|Bacteria,1NANJ@1224|Proteobacteria,1SDCV@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_548298_1 1220589.CD32_18940 3.23e-24 101.0 COG2514@1|root,COG2514@2|Bacteria,1TPRF@1239|Firmicutes,4HAE7@91061|Bacilli,3IWSS@400634|Lysinibacillus 91061|Bacilli S Glyoxalase catE - 1.13.11.2 ko:K07104 ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220 M00569 R00816,R04089,R05295,R05404,R05406,R07795 RC00387,RC00643,RC01075,RC01364,RC01914 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase k59_862638_1 333138.LQ50_17505 0.000643 43.9 COG1251@1|root,COG1251@2|Bacteria,1TQYX@1239|Firmicutes,4HASM@91061|Bacilli,1ZQ9P@1386|Bacillus 91061|Bacilli C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family nasD - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_86879_2 272952.HpaP802767 3.93e-16 78.2 COG0326@1|root,KOG0019@2759|Eukaryota,3QD9F@4776|Peronosporales 4776|Peronosporales O Hsp90 protein - - - ko:K09488 - - - - ko00000,ko03110 - - - HATPase_c_3,HSP90 k59_1288995_1 330214.NIDE4267 9.2e-112 328.0 COG3794@1|root,COG3794@2|Bacteria 2|Bacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - CarboxypepD_reg,fn3_3 k59_340758_1 1283300.ATXB01000001_gene1784 1.02e-56 186.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1XDJA@135618|Methylococcales 135618|Methylococcales S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 k59_86884_1 330214.NIDE3434 3.7e-27 108.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - pilI - - - - - - - - - - - ABC2_membrane_2 k59_86884_2 1192034.CAP_9007 8.15e-31 120.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NSM@68525|delta/epsilon subdivisions,2WJXQ@28221|Deltaproteobacteria,2YUS3@29|Myxococcales 28221|Deltaproteobacteria V ABC transporter, ATP-binding protein pilH - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1442442_1 1469245.JFBG01000027_gene1470 1.72e-205 581.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria 1224|Proteobacteria E ABC-Type Dipeptide Transport System Periplasmic Component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1289017_1 1121106.JQKB01000065_gene5222 3.81e-23 95.9 COG0028@1|root,COG0028@2|Bacteria,1R6QP@1224|Proteobacteria,2TXAJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - - - - - - - - - - TPP_enzyme_C k59_1289017_2 1380394.JADL01000009_gene3408 7.58e-19 81.6 COG4032@1|root,COG4032@2|Bacteria,1P0HU@1224|Proteobacteria,2TRJ2@28211|Alphaproteobacteria,2JS9A@204441|Rhodospirillales 204441|Rhodospirillales S Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - - - - - - - - - - TPP_enzyme_N k59_548319_1 287.DR97_5225 1.24e-43 144.0 COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,1S6Y1@1236|Gammaproteobacteria,1YG86@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K MerR family regulatory protein VL23_01195 - - - - - - - - - - - MerR_1 k59_548319_2 472759.Nhal_3202 2.92e-41 138.0 COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,1S61Z@1236|Gammaproteobacteria,1WYKZ@135613|Chromatiales 135613|Chromatiales K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control himA - - ko:K04764 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_915277_1 999141.GME_03722 6.51e-66 213.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1XIQQ@135619|Oceanospirillales 135619|Oceanospirillales M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_235370_1 1229909.NSED_09395 5.46e-50 162.0 COG2453@1|root,arCOG03413@2157|Archaea,41SK5@651137|Thaumarchaeota 651137|Thaumarchaeota T Dual specificity phosphatase, catalytic domain - - 3.1.3.16,3.1.3.48 ko:K14165 - - - - ko00000,ko01000,ko01009 - - - DSPc k59_235370_2 1229909.NSED_09390 1.68e-15 68.9 arCOG08748@1|root,arCOG08748@2157|Archaea,41TAF@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_235370_3 1229909.NSED_09385 5.7e-28 101.0 arCOG08748@1|root,arCOG08748@2157|Archaea,41SV7@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_915286_1 1210884.HG799465_gene12245 3.62e-69 219.0 COG1089@1|root,COG1089@2|Bacteria,2IWZ4@203682|Planctomycetes 203682|Planctomycetes M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_548327_1 1192034.CAP_8987 6.28e-93 289.0 COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria,43A4M@68525|delta/epsilon subdivisions,2WYKE@28221|Deltaproteobacteria,2Z0NN@29|Myxococcales 28221|Deltaproteobacteria E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_242560_1 314278.NB231_15358 6.91e-41 148.0 COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,1S03J@1236|Gammaproteobacteria,1WYH5@135613|Chromatiales 135613|Chromatiales S Major facilitator superfamily - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_1506415_2 396588.Tgr7_0333 4.8e-91 282.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1WWMQ@135613|Chromatiales 135613|Chromatiales C PFAM Aldehyde dehydrogenase - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_185272_1 88036.EFJ21685 2.7e-15 80.9 COG0661@1|root,KOG1235@2759|Eukaryota,37N5M@33090|Viridiplantae,3GF6V@35493|Streptophyta 35493|Streptophyta S domain-containing protein - - - ko:K08869 - - - - ko00000,ko01001 - - - ABC1,Beta-lactamase,WaaY k59_1081112_1 566466.NOR53_1273 1.6e-05 52.4 COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,1SM0B@1236|Gammaproteobacteria,1J7TW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sortilin, neurotensin receptor 3, - - - - - - - - - - - - - k59_869252_1 42256.RradSPS_3034 3.06e-58 199.0 COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,4CSAD@84995|Rubrobacteria 84995|Rubrobacteria C FAD dependent oxidoreductase - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_1448893_1 935261.JAGL01000015_gene3731 1.18e-38 142.0 COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,2TVK6@28211|Alphaproteobacteria,43IKQ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E N-formylglutamate amidohydrolase - - - - - - - - - - - - FGase k59_1334887_1 1229909.NSED_09915 6.59e-89 265.0 COG2242@1|root,arCOG00977@2157|Archaea,41SID@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 cbiT - 2.1.1.196 ko:K02191 ko00860,map00860 - R05813,R07774 RC00003,RC02052,RC02054 ko00000,ko00001,ko01000 - - - Methyltransf_31 k59_924546_1 1229909.NSED_05295 1.89e-89 271.0 COG2064@1|root,arCOG01808@2157|Archaea 2157|Archaea NU Type II secretion system - - - ko:K07333 - - - - ko00000,ko02035,ko02044 - - - T2SSF k59_671848_1 1380394.JADL01000011_gene3854 4.61e-14 70.9 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria,2JSM7@204441|Rhodospirillales 204441|Rhodospirillales I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_671848_2 5270.UM01923P0 1.86e-23 100.0 COG1804@1|root,KOG3957@2759|Eukaryota,38CWZ@33154|Opisthokonta,3NU4P@4751|Fungi,3UXUJ@5204|Basidiomycota,3N0QX@452284|Ustilaginomycotina 4751|Fungi I CoA-transferase family III - - 2.8.3.13 ko:K18703 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_1540107_1 330214.NIDE4318 2.41e-91 295.0 COG1197@1|root,COG1197@2|Bacteria,3J0BA@40117|Nitrospirae 40117|Nitrospirae L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_297484_1 1220582.RRU01S_12_01530 1.17e-25 112.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2V3KD@28211|Alphaproteobacteria,4B882@82115|Rhizobiaceae 28211|Alphaproteobacteria T Histidine kinase barA - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_764168_1 911045.PSE_1953 1.73e-26 113.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_973203_1 1348657.M622_04415 1.25e-76 245.0 COG0318@1|root,COG0318@2|Bacteria,1MWSD@1224|Proteobacteria,2VR64@28216|Betaproteobacteria 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.48 ko:K02182 - - - - ko00000,ko01000 - - - AMP-binding,AMP-binding_C k59_1334897_1 1030157.AFMP01000065_gene1128 7.37e-20 89.0 COG1309@1|root,COG1309@2|Bacteria,1NM2A@1224|Proteobacteria,2VE44@28211|Alphaproteobacteria,2K3MQ@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_869282_1 1125863.JAFN01000001_gene1438 6.47e-90 292.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_607352_1 1158756.AQXQ01000012_gene1265 6.58e-07 57.4 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_9 k59_607353_1 298386.PBPRA0788 1.01e-108 347.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1XTXA@135623|Vibrionales 135623|Vibrionales F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_1659769_1 598659.NAMH_0018 3.76e-18 89.4 COG1351@1|root,COG1351@2|Bacteria 2|Bacteria F thymidylate synthase (FAD) activity thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_869289_1 713586.KB900536_gene1195 2.82e-94 290.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1WX4H@135613|Chromatiales 135613|Chromatiales M PFAM peptidase - - - - - - - - - - - - OapA,Peptidase_M23 k59_829052_1 1229909.NSED_08160 2.32e-71 219.0 arCOG08637@1|root,arCOG08637@2157|Archaea,41SV0@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_924579_1 436308.Nmar_0319 1.14e-47 159.0 COG2178@1|root,arCOG04318@2157|Archaea,41SKR@651137|Thaumarchaeota 651137|Thaumarchaeota J Translin family - - - ko:K07477 - - - - ko00000 - - - Translin k59_924579_2 436308.Nmar_0320 1.38e-83 251.0 COG0063@1|root,arCOG00018@2157|Archaea,41SHM@651137|Thaumarchaeota 651137|Thaumarchaeota G Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX nnrE - 5.1.99.6 ko:K17759 - - - - ko00000,ko01000 - - - YjeF_N k59_671902_2 626887.J057_08821 0.000265 44.7 COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,1S3A6@1236|Gammaproteobacteria,465SW@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0810 Periplasmic protein TonB, links inner and outer membranes tonB3 - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_1300469_1 1433126.BN938_0150 2.55e-38 141.0 COG0714@1|root,COG0714@2|Bacteria,4NDVZ@976|Bacteroidetes,2FMGP@200643|Bacteroidia,22U05@171550|Rikenellaceae 976|Bacteroidetes S ATPase family associated with various cellular activities (AAA) moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1179685_2 1454004.AW11_02688 8.4e-45 154.0 29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,2VR98@28216|Betaproteobacteria,1KQVH@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF4390) - - - - - - - - - - - - DUF4390 k59_673498_1 330214.NIDE1867 6.11e-26 103.0 2FKUS@1|root,34CF5@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_298696_1 866536.Belba_2877 1.1e-40 157.0 COG2866@1|root,COG2866@2|Bacteria,4NGIE@976|Bacteroidetes,47N2M@768503|Cytophagia 976|Bacteroidetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_1082312_2 861299.J421_2056 5.18e-10 65.1 COG2234@1|root,COG2234@2|Bacteria 2|Bacteria DZ aminopeptidase activity - - - - - - - - - - - - Peptidase_M28 k59_1661358_1 530564.Psta_4240 6.03e-12 71.2 COG4260@1|root,COG4260@2|Bacteria,2IYIR@203682|Planctomycetes 203682|Planctomycetes S virion core protein (lumpy skin disease virus) - - - - - - - - - - - - Band_7_1,DUF4339 k59_673511_1 397287.C807_03324 1.63e-49 169.0 COG0863@1|root,COG0863@2|Bacteria,1V0ZF@1239|Firmicutes,24CQV@186801|Clostridia,27N66@186928|unclassified Lachnospiraceae 186801|Clostridia L DNA methylase - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_298699_1 1223521.BBJX01000001_gene796 3.07e-05 48.5 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,4AA8D@80864|Comamonadaceae 28216|Betaproteobacteria M TIGRFAM penicillin-binding protein, 1A family mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_298699_2 640081.Dsui_1184 7.32e-34 119.0 COG1965@1|root,COG1965@2|Bacteria,1RH9A@1224|Proteobacteria,2VVS3@28216|Betaproteobacteria,2KWZ7@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the frataxin cyaY - - ko:K06202 - - - - ko00000 - - - Frataxin_Cyay k59_715865_1 485913.Krac_6942 3.16e-43 155.0 COG4584@1|root,COG4584@2|Bacteria,2G808@200795|Chloroflexi 200795|Chloroflexi L Integrase core domain - - - - - - - - - - - - rve k59_186256_1 443255.SCLAV_4921 0.0009 48.9 COG3420@1|root,COG3420@2|Bacteria,2GNYS@201174|Actinobacteria 201174|Actinobacteria P Periplasmic copper-binding protein (NosD) - - - - - - - - - - - - Beta_helix k59_143336_1 444862.E3SM06_9CAUD 1.44e-40 144.0 4QHGQ@10239|Viruses,4QXXQ@35237|dsDNA viruses no RNA stage,4QQMM@28883|Caudovirales,4QK7P@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_974384_1 1121939.L861_18905 3.13e-52 171.0 COG1628@1|root,COG1628@2|Bacteria,1RCX1@1224|Proteobacteria,1S7VS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function DUF99 - - - ko:K09120 - - - - ko00000 - - - DUF99 k59_974384_2 483219.LILAB_16320 7.51e-54 172.0 COG0251@1|root,COG0251@2|Bacteria,1RES6@1224|Proteobacteria,435VN@68525|delta/epsilon subdivisions,2X0B9@28221|Deltaproteobacteria,2Z1FV@29|Myxococcales 28221|Deltaproteobacteria J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_974384_3 111781.Lepto7376_3060 5.56e-27 105.0 COG3384@1|root,COG3384@2|Bacteria,1GC5F@1117|Cyanobacteria,1HFH7@1150|Oscillatoriales 1117|Cyanobacteria S Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B - - - ko:K15777 ko00965,map00965 - R08836 RC00387 ko00000,ko00001,ko01000 - - - LigB k59_765336_1 469381.Dpep_2004 0.000152 43.9 COG0106@1|root,COG0106@2|Bacteria,3TAX8@508458|Synergistetes 508458|Synergistetes E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_765336_2 1131269.AQVV01000004_gene587 9.58e-80 244.0 COG0107@1|root,COG0107@2|Bacteria 2|Bacteria E imidazoleglycerol-phosphate synthase activity hisF GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_870474_1 1356854.N007_18685 8e-57 192.0 COG3666@1|root,COG3666@2|Bacteria,1TQQ9@1239|Firmicutes,4H9KK@91061|Bacilli 91061|Bacilli L Transposase - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_1026791_1 1125863.JAFN01000001_gene2673 9.33e-137 402.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2WIK7@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_673575_2 391625.PPSIR1_35322 1.5e-119 349.0 COG4422@1|root,COG4422@2|Bacteria,1MXQI@1224|Proteobacteria,42NZ6@68525|delta/epsilon subdivisions,2WKPZ@28221|Deltaproteobacteria,2YWD6@29|Myxococcales 28221|Deltaproteobacteria S Pfam:Gp37_Gp68 - - - - - - - - - - - - DUF5131 k59_556785_1 1141136.K4F6U7_9CAUD 4.82e-44 154.0 4QG1R@10239|Viruses,4QZZI@35237|dsDNA viruses no RNA stage,4QPEI@28883|Caudovirales,4QIQN@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_556787_1 998088.B565_0170 9.7e-56 185.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1Y3T2@135624|Aeromonadales 135624|Aeromonadales I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_1449958_1 436308.Nmar_1721 1.8e-130 380.0 COG0452@1|root,arCOG01704@2157|Archaea,41SYG@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine - - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_97440_1 224911.27355261 5.77e-38 142.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2TW3U@28211|Alphaproteobacteria,3JUDT@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004,ko:K05685 ko02010,map02010 M00258,M00709 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.122.1,3.A.1.122.12 - - FtsX,MacB_PCD k59_925827_1 7897.ENSLACP00000005308 7.29e-27 107.0 COG0516@1|root,KOG2550@2759|Eukaryota,38BP6@33154|Opisthokonta,3BAD2@33208|Metazoa,3CRAZ@33213|Bilateria,487ZH@7711|Chordata,48WCU@7742|Vertebrata 33208|Metazoa F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides GMPR2 GO:0002376,GO:0002520,GO:0002521,GO:0002573,GO:0003674,GO:0003824,GO:0003920,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006163,GO:0006195,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009126,GO:0009128,GO:0009150,GO:0009154,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009167,GO:0009169,GO:0009259,GO:0009261,GO:0009987,GO:0016491,GO:0016651,GO:0016657,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030097,GO:0030099,GO:0030154,GO:0030224,GO:0032501,GO:0032502,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0043094,GO:0043101,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046038,GO:0046128,GO:0046130,GO:0046434,GO:0046483,GO:0046700,GO:0048513,GO:0048534,GO:0048731,GO:0048856,GO:0048869,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901068,GO:1901069,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1903131 1.7.1.7 ko:K00364 ko00230,map00230 - R01134 RC00457 ko00000,ko00001,ko01000 - - - IMPDH k59_830761_1 1142394.PSMK_12210 9.11e-15 81.3 COG0559@1|root,COG1413@1|root,COG4177@1|root,COG0559@2|Bacteria,COG1413@2|Bacteria,COG4177@2|Bacteria,2IWS7@203682|Planctomycetes 203682|Planctomycetes E Branched-chain amino acid transport system / permease component - - - ko:K01997,ko:K11960 ko02010,ko02024,map02010,map02024 M00237,M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4,3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_974443_1 1521187.JPIM01000078_gene1054 6.25e-28 114.0 COG0500@1|root,COG2226@2|Bacteria,2G948@200795|Chloroflexi,376TJ@32061|Chloroflexia 32061|Chloroflexia Q Methyltransferase type 12 - - - - - - - - - - - - Methyltransf_11 k59_974445_1 105559.Nwat_1338 1.06e-34 129.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1WX22@135613|Chromatiales 135613|Chromatiales IQ Belongs to the beta-ketoacyl-ACP synthases family - - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_974445_2 1158292.JPOE01000002_gene3640 8.64e-69 211.0 COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,2VQ71@28216|Betaproteobacteria,1KN9C@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length fabA - 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_1179771_2 1089552.KI911559_gene1422 3.22e-23 99.0 COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2TR20@28211|Alphaproteobacteria,2JPF7@204441|Rhodospirillales 204441|Rhodospirillales H ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity - - - ko:K06048 - - - - ko00000,ko01000 - - - GCS2 k59_1082412_1 367737.Abu_1426 8.13e-09 57.8 COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,42NQ3@68525|delta/epsilon subdivisions,2YMRF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Ni Fe-hydrogenase, b-type cytochrome subunit hydC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Ni_hydr_CYTB k59_1082412_2 243159.AFE_3286 1.69e-47 169.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family hydB - 1.12.5.1,1.12.99.6 ko:K05922,ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_102851_1 926549.KI421517_gene3736 1.06e-163 491.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes,47KS7@768503|Cytophagia 976|Bacteroidetes EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_931306_1 1552758.NC00_01795 7.51e-08 58.5 COG4970@1|root,COG4970@2|Bacteria,1N7RS@1224|Proteobacteria,1SCFB@1236|Gammaproteobacteria,1X7PF@135614|Xanthomonadales 135614|Xanthomonadales NU Type II transport protein GspH - - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_931306_2 395493.BegalDRAFT_3063 6.56e-23 94.4 COG4967@1|root,COG4967@2|Bacteria,1N6TG@1224|Proteobacteria,1SC9Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU type IV pilus modification protein PilV - - - ko:K02671 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_249055_1 1071679.BG57_05260 5.53e-56 184.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VHUC@28216|Betaproteobacteria,1K4YM@119060|Burkholderiaceae 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_1184198_2 1121377.KB906399_gene1721 0.00027 48.9 COG0526@1|root,COG0526@2|Bacteria,1WJ2P@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus CO periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily - - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA k59_1247369_1 1304883.KI912532_gene562 3.48e-87 272.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2VH37@28216|Betaproteobacteria,2KUE9@206389|Rhodocyclales 206389|Rhodocyclales C Electron transfer flavoprotein-ubiquinone oxidoreductase - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,NAD_binding_8 k59_875711_1 439235.Dalk_3373 2.99e-67 224.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42N1H@68525|delta/epsilon subdivisions,2WJ0R@28221|Deltaproteobacteria,2MHVX@213118|Desulfobacterales 28221|Deltaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_406869_2 1244083.CSUNSWCD_1133 3.55e-47 163.0 COG4314@1|root,COG4314@2|Bacteria,1R8N3@1224|Proteobacteria,42M7R@68525|delta/epsilon subdivisions,2YN99@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C lipoprotein involved in nitrous oxide reduction - - - - - - - - - - - - - k59_406869_3 522306.CAP2UW1_3417 1.84e-31 118.0 COG2863@1|root,COG2863@2|Bacteria,1R6DK@1224|Proteobacteria,2VNV6@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrom_C k59_1455626_2 391625.PPSIR1_07757 4.62e-96 291.0 COG0332@1|root,COG0332@2|Bacteria,1RB9M@1224|Proteobacteria,42YNV@68525|delta/epsilon subdivisions,2WTQM@28221|Deltaproteobacteria,2YYYC@29|Myxococcales 28221|Deltaproteobacteria I 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III - - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_771710_1 545264.KB898746_gene934 2.92e-125 388.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1WXM6@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_305587_2 509635.N824_03940 0.000775 47.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Glyco_hydro_cc,Sigma70_r2,Sigma70_r4_2 k59_1341582_2 1206730.BAGA01000086_gene515 1.54e-25 106.0 COG1028@1|root,COG1028@2|Bacteria,2GIX2@201174|Actinobacteria,4FWWE@85025|Nocardiaceae 201174|Actinobacteria IQ KR domain - - - ko:K07535 ko00362,ko01120,ko01220,map00362,map01120,map01220 M00540 R05582 RC00154 ko00000,ko00001,ko00002,ko01000 - - - adh_short_C2 k59_1248492_1 870187.Thini_1983 1.94e-13 69.7 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,4600Q@72273|Thiotrichales 72273|Thiotrichales O PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7 k59_1248492_2 1397528.Q671_01545 1.83e-48 171.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria,1XIN1@135619|Oceanospirillales 135619|Oceanospirillales O NfeD-like C-terminal, partner-binding - - - ko:K07403 - - - - ko00000 - - - NfeD k59_104175_1 68223.JNZY01000024_gene6406 9.37e-34 131.0 COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria 201174|Actinobacteria C FAD linked agpS - 2.5.1.26 ko:K00803 ko00565,ko01100,ko04146,map00565,map01100,map04146 - R04311 RC00020,RC02886 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_876959_2 683083.C414_000080009 1.09e-06 53.9 2EJ8Y@1|root,33D05@2|Bacteria,1NI81@1224|Proteobacteria 1224|Proteobacteria S A blastn search against coding sequences extracted from AL111168.1, CP000025.1, CP000538.1, CP000768.1, CP000814.1 failed to identify a - - - - - - - - - - - - - k59_876959_3 753085.F4YCT2_9CAUD 2.22e-16 79.3 4QGP7@10239|Viruses,4R0IR@35237|dsDNA viruses no RNA stage,4QQ0Q@28883|Caudovirales,4QKUN@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_104180_1 1437329.A0A0A8KWW5_9CAUD 4e-53 179.0 4QARC@10239|Viruses,4QV4E@35237|dsDNA viruses no RNA stage,4QPDS@28883|Caudovirales,4QP0H@10744|Podoviridae 10744|Podoviridae S nucleic acid binding - - - - - - - - - - - - - k59_1033457_1 471223.GWCH70_0414 0.000183 46.2 COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,1TRH0@1239|Firmicutes,4HBC2@91061|Bacilli,1WHCM@129337|Geobacillus 91061|Bacilli T Signal transduction histidine kinase, nitrogen specific, NtrB - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_104193_1 713587.THITH_07425 1.04e-67 223.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1SMH6@1236|Gammaproteobacteria,1X0JB@135613|Chromatiales 135613|Chromatiales E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1248526_1 1198452.Jab_2c30110 6.64e-05 45.8 COG3663@1|root,COG3663@2|Bacteria,1REPV@1224|Proteobacteria,2VRAT@28216|Betaproteobacteria,474IV@75682|Oxalobacteraceae 28216|Betaproteobacteria L Uracil DNA glycosylase superfamily mug - 3.2.2.28 ko:K03649 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1248526_2 551789.ATVJ01000003_gene208 1.68e-30 112.0 COG0346@1|root,COG0346@2|Bacteria,1N1D4@1224|Proteobacteria,2UBYV@28211|Alphaproteobacteria,43Y5Z@69657|Hyphomonadaceae 28211|Alphaproteobacteria E COG0346 Lactoylglutathione lyase and related lyases - - - - - - - - - - - - Glyoxalase k59_615240_1 436308.Nmar_0849 4.24e-63 201.0 arCOG08708@1|root,arCOG08708@2157|Archaea,41SPK@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_932730_1 264732.Moth_0263 6.12e-42 150.0 COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,42F8F@68295|Thermoanaerobacterales 186801|Clostridia F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_932730_2 383372.Rcas_0991 3.69e-32 120.0 COG0149@1|root,COG0149@2|Bacteria,2G69W@200795|Chloroflexi,3750D@32061|Chloroflexia 32061|Chloroflexia F Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_1141396_1 330214.NIDE0486 3.32e-59 197.0 COG0165@1|root,COG0165@2|Bacteria,3J0EN@40117|Nitrospirae 40117|Nitrospirae E Argininosuccinate lyase C-terminal argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_1089054_1 1415754.JQMK01000002_gene3606 3.96e-26 105.0 COG1596@1|root,COG1596@2|Bacteria,1RFBH@1224|Proteobacteria,1S35N@1236|Gammaproteobacteria,464WW@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG1596 Periplasmic protein involved in polysaccharide export wza - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB k59_1089054_2 204669.Acid345_4134 1.71e-107 329.0 COG2204@1|root,COG2204@2|Bacteria,3Y41F@57723|Acidobacteria,2JIZR@204432|Acidobacteriia 204432|Acidobacteriia T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_462970_1 323261.Noc_1276 6.88e-53 184.0 COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,1S3MR@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_19646_1 1288494.EBAPG3_29640 6.35e-103 306.0 COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,2VK2N@28216|Betaproteobacteria 28216|Betaproteobacteria GM Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction fcl - 1.1.1.271 ko:K02377 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R05692 RC01014 ko00000,ko00001,ko01000 - - - Epimerase k59_104212_1 880073.Calab_0526 4.64e-09 63.2 COG1404@1|root,COG3291@1|root,COG3386@1|root,COG5276@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria,COG5276@2|Bacteria 2|Bacteria G gluconolactonase activity - - 3.1.1.17,3.2.1.4 ko:K01053,ko:K01179,ko:K07214,ko:K12287 ko00030,ko00053,ko00500,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00500,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02933,R03751,R06200,R11307,R11308 RC00537,RC00983 ko00000,ko00001,ko00002,ko01000,ko02044,ko04147 - GH5,GH9 - Big_5,DUF285,Esterase,He_PIG,SGL k59_615257_2 1532557.JL37_19520 4.29e-29 120.0 COG1053@1|root,COG1053@2|Bacteria,1QWW9@1224|Proteobacteria,2WH2Y@28216|Betaproteobacteria,3T7DM@506|Alcaligenaceae 28216|Betaproteobacteria C FAD dependent oxidoreductase - - - - - - - - - - - - FAD_oxidored k59_1605493_2 477974.Daud_2024 1.34e-21 91.7 COG0070@1|root,COG0070@2|Bacteria,1TQEB@1239|Firmicutes,24AQ1@186801|Clostridia,261IX@186807|Peptococcaceae 186801|Clostridia E PFAM glutamate synthase alpha subunit - - - - - - - - - - - - GXGXG k59_1185405_2 1279009.ADICEAN_03033 0.000747 42.4 COG3004@1|root,COG3004@2|Bacteria,4NFC4@976|Bacteroidetes,47JZ0@768503|Cytophagia 976|Bacteroidetes P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_149349_1 440512.C211_11387 1.64e-50 176.0 COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,1RPXH@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Succinate dehydrogenase fumarate reductase, flavoprotein subunit - - 1.3.99.33 ko:K17363 ko00340,map00340 - R10330 RC00669 ko00000,ko00001,ko01000 - - - FAD_binding_2,FMN_bind k59_563331_2 1123234.AUKI01000015_gene2306 3.62e-08 57.8 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glycos_transf_2 k59_250404_1 866895.HBHAL_5049 1.66e-07 55.5 COG0477@1|root,COG2814@2|Bacteria,1UV35@1239|Firmicutes,4IJSX@91061|Bacilli,3NFNE@45667|Halobacillus 91061|Bacilli EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1 k59_149353_1 1267535.KB906767_gene913 2.6e-15 84.7 COG4775@1|root,COG4775@2|Bacteria,3Y2Q9@57723|Acidobacteria,2JHYD@204432|Acidobacteriia 204432|Acidobacteriia M TIGRFAM outer membrane protein assembly complex, YaeT protein - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1185419_1 1229909.NSED_08160 1.54e-46 155.0 arCOG08637@1|root,arCOG08637@2157|Archaea,41SV0@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1141451_2 401526.TcarDRAFT_0963 7.42e-09 60.1 COG0579@1|root,COG0579@2|Bacteria,1TRDH@1239|Firmicutes,4H2AD@909932|Negativicutes 909932|Negativicutes C FAD dependent oxidoreductase - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,Fer2_BFD k59_1248570_1 713586.KB900536_gene1002 1.21e-15 75.5 COG0790@1|root,COG0790@2|Bacteria,1PFSC@1224|Proteobacteria,1TJ65@1236|Gammaproteobacteria,1WY15@135613|Chromatiales 135613|Chromatiales S Sel1-like repeats. - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_19662_1 760117.JN27_08895 1.84e-39 142.0 COG1028@1|root,COG1028@2|Bacteria,1QU4S@1224|Proteobacteria,2VH03@28216|Betaproteobacteria,47439@75682|Oxalobacteraceae 28216|Betaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short k59_104253_1 880070.Cycma_2062 3.08e-49 172.0 COG3394@1|root,COG3394@2|Bacteria,4NKJ2@976|Bacteroidetes,47NPC@768503|Cytophagia 976|Bacteroidetes G YdjC-like protein - - 3.5.1.105 ko:K03478 - - - - ko00000,ko01000 - - - YdjC k59_1185428_1 1121456.ATVA01000011_gene1656 7.65e-36 137.0 COG1463@1|root,COG1463@2|Bacteria,1MYEF@1224|Proteobacteria,42SPY@68525|delta/epsilon subdivisions,2X5NV@28221|Deltaproteobacteria,2MGTK@213115|Desulfovibrionales 28221|Deltaproteobacteria Q MlaD protein - - - ko:K06192 - - - - ko00000 - - - MlaD k59_357667_1 929558.SMGD1_2448 2.24e-24 106.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2YMHP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF k59_1141465_1 1300345.LF41_972 4.33e-19 94.7 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1SZUM@1236|Gammaproteobacteria,1X325@135614|Xanthomonadales 135614|Xanthomonadales S ABC transporter substrate-binding protein - - - - - - - - - - - - ABC1 k59_932800_1 1636182.A0A0F6R513_9CAUD 3.54e-09 61.6 4QAK6@10239|Viruses,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_149375_1 349124.Hhal_1366 1.69e-21 90.9 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,1RP3R@1236|Gammaproteobacteria,1WX10@135613|Chromatiales 135613|Chromatiales U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm k59_149375_2 452638.Pnec_1382 1.48e-41 144.0 COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2VNPU@28216|Betaproteobacteria,1K602@119060|Burkholderiaceae 28216|Betaproteobacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmB - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB k59_1548140_1 489825.LYNGBM3L_21220 2.47e-69 233.0 COG1216@1|root,COG5309@1|root,COG1216@2|Bacteria,COG5309@2|Bacteria,1G2MT@1117|Cyanobacteria,1H8YG@1150|Oscillatoriales 1117|Cyanobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glyco_hydro_2_C,Glycos_transf_2 k59_104271_2 330214.NIDE4084 2.36e-43 152.0 COG0823@1|root,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PA,PD40,PDZ_2,Peptidase_M28 k59_1089131_1 426117.M446_4618 2.28e-31 122.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TUKZ@28211|Alphaproteobacteria,1JSNK@119045|Methylobacteriaceae 28211|Alphaproteobacteria J Belongs to the amidase family - - 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_771816_1 472759.Nhal_3349 7.86e-20 94.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1089133_1 1163617.SCD_n00904 2.63e-34 135.0 COG2199@1|root,COG2200@1|root,COG5002@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WHDZ@28216|Betaproteobacteria 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_4,PAS_9 k59_193233_1 1118235.CAJH01000047_gene2958 6.14e-45 159.0 COG2084@1|root,COG2084@2|Bacteria,1RA7F@1224|Proteobacteria,1RMMY@1236|Gammaproteobacteria,1X5AQ@135614|Xanthomonadales 135614|Xanthomonadales I Belongs to the 3-hydroxyisobutyrate dehydrogenase family mmsB - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1605526_1 1515746.HR45_00565 2.99e-100 317.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,2Q9A7@267890|Shewanellaceae 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1605526_2 713586.KB900536_gene1141 6.94e-64 211.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1WXE2@135613|Chromatiales 135613|Chromatiales EGP PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_563382_1 1227352.C173_05756 1.22e-09 58.2 COG0315@1|root,COG0315@2|Bacteria,1V3J4@1239|Firmicutes,4HH39@91061|Bacilli,26WTM@186822|Paenibacillaceae 91061|Bacilli H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC k59_563382_2 720555.BATR1942_13040 1.13e-08 60.5 COG2267@1|root,COG2267@2|Bacteria,1UZ5S@1239|Firmicutes,4HEHP@91061|Bacilli,1ZBD1@1386|Bacillus 91061|Bacilli I Alpha beta hydrolase ytpA GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0008150,GO:0008152,GO:0016020,GO:0016298,GO:0016787,GO:0016788,GO:0044238,GO:0071704 3.1.1.5 ko:K01048 ko00564,map00564 - - - ko00000,ko00001,ko01000 - - - Hydrolase_4 k59_1033539_3 1197951.I6S295_9CAUD 2.72e-24 93.6 4QCEX@10239|Viruses,4QV7Q@35237|dsDNA viruses no RNA stage,4QU8B@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_771826_2 2342.SOPEG_2945 1.12e-22 99.8 COG2981@1|root,COG2981@2|Bacteria,1MVFT@1224|Proteobacteria,1RMQT@1236|Gammaproteobacteria 1236|Gammaproteobacteria U High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway cysZ GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008150,GO:0008152,GO:0008271,GO:0008272,GO:0008324,GO:0008509,GO:0008512,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009675,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015103,GO:0015116,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015296,GO:0015318,GO:0015672,GO:0015698,GO:0016020,GO:0016021,GO:0016053,GO:0019344,GO:0019752,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044425,GO:0044459,GO:0044464,GO:0046394,GO:0051179,GO:0051234,GO:0055085,GO:0071704,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0098660,GO:0098661,GO:0098662,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682,GO:1902358,GO:1902600 - ko:K06203 - - - - ko00000 - - iJR904.b2413,iYL1228.KPN_02760 EI24 k59_357697_1 56110.Oscil6304_4221 1.48e-36 146.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_193251_1 177437.HRM2_35260 2.54e-39 144.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,42S9I@68525|delta/epsilon subdivisions,2WNTW@28221|Deltaproteobacteria,2MJMG@213118|Desulfobacterales 28221|Deltaproteobacteria M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_1455766_1 748247.AZKH_p0168 3.34e-28 108.0 28I8Y@1|root,2Z8BR@2|Bacteria,1MXN1@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF1638) - - - - - - - - - - - - DUF1638 k59_1455766_2 748247.AZKH_p0167 5.33e-28 105.0 2CDZD@1|root,32RYT@2|Bacteria,1N0AT@1224|Proteobacteria 1224|Proteobacteria S Virulence factor - - - - - - - - - - - - Virulence_fact k59_1455766_3 998674.ATTE01000001_gene275 4.52e-19 82.0 COG0685@1|root,COG0685@2|Bacteria,1RHDY@1224|Proteobacteria,1T0DC@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Methylene-tetrahydrofolate reductase C terminal - - - - - - - - - - - - MTHFR_C k59_722578_1 105559.Nwat_0840 4.23e-34 133.0 28MV6@1|root,2ZB2T@2|Bacteria,1R710@1224|Proteobacteria,1SMZR@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_33997_1 1165094.RINTHH_6140 1.97e-06 49.7 COG1259@1|root,COG1259@2|Bacteria,1G4YX@1117|Cyanobacteria,1HJ2E@1161|Nostocales 1117|Cyanobacteria S PFAM Uncharacterised ACR, COG1259 - - - ko:K08999 - - - - ko00000 - - - DNase-RNase k59_33997_2 1380370.JIBA01000013_gene1399 9.95e-20 86.7 COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria,4FGHI@85021|Intrasporangiaceae 201174|Actinobacteria S Bifunctional nuclease - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K08999 - - - - ko00000 - - - DNase-RNase k59_34015_1 330214.NIDE2731 1.89e-103 308.0 COG0182@1|root,COG0182@2|Bacteria,3J0G0@40117|Nitrospirae 40117|Nitrospirae E Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B k59_34042_2 288000.BBta_6157 7.14e-17 83.6 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,3JUVV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Flavin containing amine oxidoreductase MA20_01895 - - - - - - - - - - - Amino_oxidase k59_34112_1 1229909.NSED_01530 8.73e-83 256.0 COG0148@1|root,arCOG01169@2157|Archaea,41SE9@651137|Thaumarchaeota 651137|Thaumarchaeota G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_34118_1 1283300.ATXB01000002_gene2581 2.67e-106 317.0 COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,1RNTN@1236|Gammaproteobacteria,1XFKZ@135618|Methylococcales 135618|Methylococcales Q Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 k59_34346_1 1301098.PKB_2148 4.15e-21 94.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c oxidase accessory protein ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_34346_2 1123487.KB892841_gene4270 1.24e-14 72.8 COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,2VTYE@28216|Betaproteobacteria,2KX1A@206389|Rhodocyclales 206389|Rhodocyclales S FixH family - - - ko:K09926 - - - - ko00000 - - - FixH k59_34361_1 639030.JHVA01000001_gene3479 1.04e-06 55.8 COG0457@1|root,COG0457@2|Bacteria,3Y3VT@57723|Acidobacteria,2JHXZ@204432|Acidobacteriia 204432|Acidobacteriia S ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_34376_1 1280686.AUKE01000020_gene2737 1.89e-27 117.0 COG1387@1|root,COG5263@1|root,COG1387@2|Bacteria,COG5263@2|Bacteria,1UDBB@1239|Firmicutes,25G22@186801|Clostridia,4BYC8@830|Butyrivibrio 186801|Clostridia E oxidoreductase activity - - - - - - - - - - - - CHB_HEX_C,CHB_HEX_C_1,CW_binding_1 k59_34414_1 1356854.N007_13980 2.57e-41 149.0 COG0287@1|root,COG0287@2|Bacteria,1UKW8@1239|Firmicutes,4ITKE@91061|Bacilli 91061|Bacilli E Domain of unknown function (DUF1932) - - - - - - - - - - - - DUF1932,F420_oxidored,NAD_binding_2 k59_34542_1 457398.HMPREF0326_05781 1.32e-15 81.6 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2M92Z@213115|Desulfovibrionales 28221|Deltaproteobacteria T SMART Adenylyl cyclase class-3 4 guanylyl cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_34564_1 1121405.dsmv_3405 2.4e-107 325.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,2MIR1@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_34614_1 1304275.C41B8_05453 4.99e-52 189.0 COG0234@1|root,COG0234@2|Bacteria,1NJKP@1224|Proteobacteria 1224|Proteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - - k59_34616_1 1469607.KK073768_gene928 8.59e-07 54.3 COG3225@1|root,COG3225@2|Bacteria,1G0JN@1117|Cyanobacteria,1HMIS@1161|Nostocales 1117|Cyanobacteria N transport system involved in gliding motility, auxiliary component - - - - - - - - - - - - ABC_transp_aux k59_34616_2 1407650.BAUB01000003_gene712 1.71e-24 105.0 COG1277@1|root,COG1277@2|Bacteria,1G272@1117|Cyanobacteria,1GYWZ@1129|Synechococcus 1117|Cyanobacteria S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3 k59_34647_1 994573.T472_0207915 1.85e-05 49.7 COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,36EVT@31979|Clostridiaceae 186801|Clostridia P Ammonium Transporter amt - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp,P-II k59_34649_1 1122603.ATVI01000005_gene3244 2.46e-09 59.7 COG2266@1|root,COG2266@2|Bacteria,1RFQ8@1224|Proteobacteria,1S0QF@1236|Gammaproteobacteria 1236|Gammaproteobacteria H MobA-like NTP transferase domain - - - - - - - - - - - - NTP_transf_3 k59_34649_2 1101190.ARWB01000001_gene2667 1.06e-12 68.9 COG1132@1|root,COG1132@2|Bacteria,1MVJD@1224|Proteobacteria,2U2HD@28211|Alphaproteobacteria,3707M@31993|Methylocystaceae 28211|Alphaproteobacteria V ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_membrane,ABC_tran k59_34690_1 595593.JREV01000049_gene1222 3.65e-13 76.6 COG1305@1|root,COG1305@2|Bacteria,2HQBB@201174|Actinobacteria 201174|Actinobacteria E PFAM transglutaminase domain protein - - - - - - - - - - - - Transglut_core k59_35073_1 1131266.ARWQ01000011_gene121 4.18e-83 256.0 COG1163@1|root,arCOG00358@2157|Archaea,41SAD@651137|Thaumarchaeota 651137|Thaumarchaeota S small GTP-binding protein - - - ko:K06944 - - - - ko00000 - - - MMR_HSR1,MMR_HSR1_Xtn,TGS k59_35219_2 1125863.JAFN01000001_gene2231 5.76e-44 150.0 COG4659@1|root,COG4659@2|Bacteria,1N2GK@1224|Proteobacteria,42UH0@68525|delta/epsilon subdivisions,2WRRX@28221|Deltaproteobacteria 28221|Deltaproteobacteria C FMN_bind - - - - - - - - - - - - - k59_35219_3 857087.Metme_0581 5.37e-40 149.0 COG2433@1|root,COG2433@2|Bacteria,1QW3W@1224|Proteobacteria,1T2RV@1236|Gammaproteobacteria,1XENI@135618|Methylococcales 135618|Methylococcales S Pfam Transposase IS66 - - - - - - - - - - - - - k59_35484_1 338963.Pcar_2003 1.97e-17 80.5 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,42RVM@68525|delta/epsilon subdivisions,2WQIY@28221|Deltaproteobacteria,43SIT@69541|Desulfuromonadales 28221|Deltaproteobacteria J Ribosomal L25p family ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_35484_2 338966.Ppro_0743 2.5e-17 81.6 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,42MI2@68525|delta/epsilon subdivisions,2WJ5W@28221|Deltaproteobacteria,43UCQ@69541|Desulfuromonadales 28221|Deltaproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2848 Pribosyl_synth,Pribosyltran_N k59_35569_1 671143.DAMO_1102 1.68e-84 272.0 COG4590@1|root,COG4590@2|Bacteria,2NS4H@2323|unclassified Bacteria 2|Bacteria U Binding-protein-dependent transport system inner membrane component pstC - - ko:K02037,ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_35628_1 392499.Swit_1834 9.67e-66 225.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,2K2DM@204457|Sphingomonadales 204457|Sphingomonadales C PFAM pyruvate ferredoxin flavodoxin oxidoreductase - - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_35631_1 926569.ANT_24640 8.44e-35 134.0 COG2006@1|root,COG2006@2|Bacteria 2|Bacteria U 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - - - - - - - - - - DUF362 k59_35769_1 595460.RRSWK_06187 9.08e-30 120.0 COG0348@1|root,COG0348@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding - - - ko:K02574 - - - - ko00000 - - - Fer4,Fer4_5 k59_35814_1 68260.JOAY01000001_gene3599 7.8e-57 189.0 COG4301@1|root,COG4301@2|Bacteria,2GJAX@201174|Actinobacteria 201174|Actinobacteria S Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine egtD - 2.1.1.44 ko:K18911 ko00340,map00340 - R01169 RC00003,RC02308 ko00000,ko00001,ko01000 - - - Methyltransf_33 k59_35843_1 519989.ECTPHS_05090 3.32e-28 114.0 COG1463@1|root,COG1463@2|Bacteria,1MYEF@1224|Proteobacteria,1S8EQ@1236|Gammaproteobacteria,1WYKW@135613|Chromatiales 135613|Chromatiales Q MlaD protein - - - ko:K06192 - - - - ko00000 - - - MlaD k59_35843_2 237368.SCABRO_03848 1.53e-25 101.0 COG1127@1|root,COG1127@2|Bacteria,2J2WI@203682|Planctomycetes 203682|Planctomycetes Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_35913_1 436308.Nmar_0514 1.89e-61 197.0 COG0667@1|root,arCOG01617@2157|Archaea,41S90@651137|Thaumarchaeota 651137|Thaumarchaeota C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_35913_2 1229909.NSED_02575 5.22e-19 80.5 arCOG10528@1|root,arCOG10528@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_35924_1 392500.Swoo_4207 8.57e-43 152.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,2Q9J3@267890|Shewanellaceae 1236|Gammaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_35924_2 1260251.SPISAL_02810 3.86e-26 106.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1WWIB@135613|Chromatiales 135613|Chromatiales E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_36081_1 472759.Nhal_0131 3.46e-176 544.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_36318_1 665029.EAMY_0434 3.78e-28 108.0 COG0494@1|root,COG0494@2|Bacteria,1RDMW@1224|Proteobacteria,1RPZV@1236|Gammaproteobacteria,3X4EP@551|Erwinia 1236|Gammaproteobacteria L NUDIX domain nudF GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019144,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0047631,GO:0050896 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - iECP_1309.ECP_3126 NUDIX k59_36343_1 331869.BAL199_15643 1.35e-65 202.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2U5SV@28211|Alphaproteobacteria,4BSBP@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Endoribonuclease L-PSP MA20_29855 - - ko:K09021 ko00240,ko01100,map00240,map01100 - R09982 RC02768 ko00000,ko00001 - - - Ribonuc_L-PSP k59_36347_1 1229909.NSED_05415 2.74e-58 186.0 COG0149@1|root,arCOG01087@2157|Archaea,41SHT@651137|Thaumarchaeota 651137|Thaumarchaeota G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_36398_1 1280950.HJO_06435 1.8e-11 69.3 COG4206@1|root,COG4206@2|Bacteria,1QVV2@1224|Proteobacteria 1224|Proteobacteria H COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_36434_1 1205680.CAKO01000002_gene2489 4.98e-76 239.0 COG2159@1|root,COG2159@2|Bacteria,1P6G6@1224|Proteobacteria,2TU10@28211|Alphaproteobacteria 28211|Alphaproteobacteria S metal-dependent hydrolase of the TIM-barrel fold - - - - - - - - - - - - Amidohydro_2 k59_36468_2 987059.RBXJA2T_03471 2.24e-53 175.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,1KIXU@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Belongs to the GST superfamily gstI - 2.5.1.18 ko:K00799,ko:K11209 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N,GST_N_2 k59_36525_2 1265503.KB905165_gene1275 1.51e-07 57.4 COG1409@1|root,COG1409@2|Bacteria 2|Bacteria S acid phosphatase activity - - - - - - - - - - - - Metallophos k59_36764_1 523791.Kkor_2630 5.71e-59 197.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1XHRG@135619|Oceanospirillales 135619|Oceanospirillales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_36953_1 330214.NIDE1634 8.17e-105 329.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,3J101@40117|Nitrospirae 40117|Nitrospirae G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_36959_1 1121403.AUCV01000005_gene207 2.64e-72 222.0 COG2020@1|root,COG2020@2|Bacteria,1R7G6@1224|Proteobacteria,42TT9@68525|delta/epsilon subdivisions 1224|Proteobacteria O methyltransferase - - - - - - - - - - - - ICMT,PEMT k59_36983_1 460265.Mnod_0487 8.17e-85 259.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,1JR8B@119045|Methylobacteriaceae 28211|Alphaproteobacteria EP Belongs to the ABC transporter superfamily dppD GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015232,GO:0015886,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678 - ko:K12371 ko02010,map02010 M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_37016_1 1442599.JAAN01000044_gene2886 6.38e-52 174.0 COG3182@1|root,COG3182@2|Bacteria,1R59B@1224|Proteobacteria,1S0MV@1236|Gammaproteobacteria,1XA11@135614|Xanthomonadales 135614|Xanthomonadales S PepSY-associated TM region - - - - - - - - - - - - PepSY_TM k59_37016_2 1280953.HOC_19016 8.9e-29 118.0 COG2871@1|root,COG3182@1|root,COG2871@2|Bacteria,COG3182@2|Bacteria,1QTUV@1224|Proteobacteria,2TWD7@28211|Alphaproteobacteria,440YP@69657|Hyphomonadaceae 28211|Alphaproteobacteria C COG2871 Na -transporting NADH ubiquinone oxidoreductase, subunit NqrF nqrF - 1.6.5.8 ko:K00351,ko:K16246 ko00361,ko00362,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00623,map01100,map01120,map01220 M00548 R03560,R03608,R10042,R10043 RC00046,RC00490 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1,PepSY_TM k59_37236_1 1278073.MYSTI_03018 9.7e-21 97.4 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,42N3S@68525|delta/epsilon subdivisions,2WJ5P@28221|Deltaproteobacteria,2YUX0@29|Myxococcales 28221|Deltaproteobacteria S DNA internalization-related competence protein ComEC Rec2 - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_37258_1 42256.RradSPS_0393 1.2e-32 124.0 COG5424@1|root,COG5424@2|Bacteria 2|Bacteria H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ - - 1.3.3.11,2.6.1.76 ko:K00836,ko:K06137 ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230 M00033 R06977 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Cupin_2,Haem_oxygenas_2 k59_37296_1 1123368.AUIS01000026_gene1464 1.03e-118 363.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,2NBVQ@225057|Acidithiobacillales 225057|Acidithiobacillales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_37365_1 1449048.JQKU01000008_gene950 1.3e-20 97.4 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,233ZQ@1762|Mycobacteriaceae 201174|Actinobacteria Q cytochrome p450 - - - - - - - - - - - - p450 k59_37416_1 436308.Nmar_0808 2.22e-91 274.0 COG0469@1|root,arCOG04071@2157|Archaea,41SHB@651137|Thaumarchaeota 651137|Thaumarchaeota J Ribosomal protein L4 - - - ko:K02930 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_37568_1 83406.HDN1F_18370 3.02e-10 61.2 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria,1J5QT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Amino acid permease - - - - - - - - - - - - AA_permease_2 k59_37568_2 1265310.CCBD010000008_gene2784 3.59e-42 151.0 COG1063@1|root,COG1063@2|Bacteria,2IBQC@201174|Actinobacteria,23300@1762|Mycobacteriaceae 201174|Actinobacteria E Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_37705_1 631362.Thi970DRAFT_02439 3.53e-97 314.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_37718_1 1273125.Rrhod_3206 2.43e-14 71.2 COG2897@1|root,COG2897@2|Bacteria,2GIYU@201174|Actinobacteria,4FVQZ@85025|Nocardiaceae 201174|Actinobacteria P Rhodanese Homology Domain sseA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_37718_2 316274.Haur_2531 1.06e-36 129.0 COG0822@1|root,COG0822@2|Bacteria,2GAEI@200795|Chloroflexi,375SH@32061|Chloroflexia 32061|Chloroflexia C PFAM nitrogen-fixing NifU domain protein - - - ko:K04488 - - - - ko00000 - - - NifU_N k59_38398_1 754477.Q7C_1935 2.09e-100 315.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,4608B@72273|Thiotrichales 72273|Thiotrichales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_941062_1 436308.Nmar_1104 4.02e-150 448.0 COG0178@1|root,arCOG04694@2157|Archaea,41T01@651137|Thaumarchaeota 651137|Thaumarchaeota L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_523102_1 1429046.RR21198_3470 9.47e-29 122.0 COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4FZD4@85025|Nocardiaceae 201174|Actinobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_314253_1 204669.Acid345_0159 3.17e-52 174.0 COG1606@1|root,COG1606@2|Bacteria,3Y30C@57723|Acidobacteria,2JKD3@204432|Acidobacteriia 204432|Acidobacteriia L tRNA processing - - - ko:K06864 - - - - ko00000 - - - NAD_synthase k59_575451_1 765910.MARPU_13730 3.46e-20 82.4 2C7TU@1|root,32RJT@2|Bacteria,1N2CD@1224|Proteobacteria,1S96C@1236|Gammaproteobacteria,1WYZ5@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_575451_2 329726.AM1_4941 1.71e-39 133.0 COG3450@1|root,COG3450@2|Bacteria,1G7YR@1117|Cyanobacteria 1117|Cyanobacteria S of the cupin superfamily - - - ko:K06995 - - - - ko00000 - - - Cupin_3 k59_1254570_2 566466.NOR53_696 1.46e-17 83.6 COG3544@1|root,COG3544@2|Bacteria,1N0KY@1224|Proteobacteria,1SBTF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF305) - - - - - - - - - - - - DUF305 k59_627862_1 1415780.JPOG01000001_gene2508 1.02e-76 254.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria,1SMN0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_262029_2 933262.AXAM01000014_gene271 1.04e-92 287.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,42M6S@68525|delta/epsilon subdivisions,2WJU8@28221|Deltaproteobacteria,2MIPX@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_157292_1 1156937.MFUM_990003 1.82e-62 204.0 COG0637@1|root,COG0637@2|Bacteria,46VII@74201|Verrucomicrobia,37GKC@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_1045550_2 1232453.BAIF02000087_gene300 1.14e-36 129.0 COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,269MZ@186813|unclassified Clostridiales 186801|Clostridia L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yrrK - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_1311090_1 1123487.KB892836_gene3111 5.04e-40 152.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHZQ@28216|Betaproteobacteria 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_841128_1 1262914.BN533_00252 4.8e-42 157.0 COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,4H360@909932|Negativicutes 909932|Negativicutes M Penicillin-binding Protein pbpD - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_736563_1 425104.Ssed_3773 4.76e-55 182.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MURA@1224|Proteobacteria,1RN27@1236|Gammaproteobacteria,2QECY@267890|Shewanellaceae 1236|Gammaproteobacteria P Metallo-beta-lactamase superfamily blh - - - - - - - - - - - Lactamase_B,Rhodanese k59_1050122_1 247490.KSU1_D0507 1.41e-68 234.0 COG2132@1|root,COG2132@2|Bacteria,2J4J4@203682|Planctomycetes 203682|Planctomycetes Q Multicopper oxidase - - - - - - - - - - - - - k59_997515_1 400682.PAC_15710327 1.26e-68 219.0 COG4579@1|root,2S4PR@2759|Eukaryota,39ZYX@33154|Opisthokonta,3BPWJ@33208|Metazoa 33208|Metazoa T Isocitrate dehydrogenase kinase/phosphatase (AceK) - - - - - - - - - - - - AceK k59_1518498_1 530564.Psta_0211 1.33e-35 125.0 COG0640@1|root,COG0640@2|Bacteria,2J0NM@203682|Planctomycetes 203682|Planctomycetes K PFAM Bacterial regulatory protein, arsR family - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5 k59_160366_1 1031711.RSPO_c02847 8.33e-103 318.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1K3N3@119060|Burkholderiaceae 28216|Betaproteobacteria JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_633545_1 402626.Rpic_3030 1.05e-20 86.7 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2VR4Y@28216|Betaproteobacteria,1K5S0@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_1572122_1 709797.CSIRO_1174 5.58e-20 85.5 COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2TSAM@28211|Alphaproteobacteria,3JV0Z@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_1572122_2 1395571.TMS3_0101955 4.69e-11 62.4 2E4CH@1|root,32Z7Y@2|Bacteria,1NBRN@1224|Proteobacteria,1SCB9@1236|Gammaproteobacteria 1236|Gammaproteobacteria S pilus assembly protein, PilZ - - - - - - - - - - - - PilZ k59_893558_1 864702.OsccyDRAFT_4785 8.3e-27 110.0 COG0334@1|root,COG0334@2|Bacteria,1G0WP@1117|Cyanobacteria,1H98K@1150|Oscillatoriales 1117|Cyanobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family gdhA GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 - R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - iJN678.gdhA ELFV_dehydrog,ELFV_dehydrog_N k59_109397_1 268746.Q58MM6_BPPRM 1.3e-119 357.0 4QHDM@10239|Viruses,4QYV6@35237|dsDNA viruses no RNA stage,4QRD0@28883|Caudovirales,4QI2W@10662|Myoviridae 10662|Myoviridae S Terminase-like family - GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016032,GO:0016043,GO:0016787,GO:0016788,GO:0019058,GO:0019068,GO:0019069,GO:0019072,GO:0019075,GO:0022607,GO:0032991,GO:0034641,GO:0043170,GO:0043493,GO:0044085,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0046483,GO:0046797,GO:0051704,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0098009,GO:1901360,GO:1902494,GO:1904949 - - - - - - - - - - - k59_893563_1 349966.DJ58_2904 8.01e-27 111.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RMCS@1236|Gammaproteobacteria,41ERB@629|Yersinia 1236|Gammaproteobacteria I Catalyzes the conversion of UDP-4-keto-arabinose (UDP- Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides arnB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0008483,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:0099620,GO:1901363 2.6.1.87 ko:K07806 ko00520,ko01503,ko02020,map00520,map01503,map02020 M00721,M00761 R07659 RC00006,RC01514 ko00000,ko00001,ko00002,ko01000,ko01005,ko01007 - - iSFxv_1172.SFxv_2574 DegT_DnrJ_EryC1 k59_58915_1 330214.NIDE0302 6.8e-105 317.0 COG0621@1|root,COG0621@2|Bacteria,3J0CD@40117|Nitrospirae 40117|Nitrospirae J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_1311117_2 472759.Nhal_1056 2.36e-77 242.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1WWRK@135613|Chromatiales 135613|Chromatiales H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_1102440_1 1266925.JHVX01000009_gene36 7.81e-09 58.5 2CAM1@1|root,301FE@2|Bacteria,1RJ36@1224|Proteobacteria,2VR84@28216|Betaproteobacteria,372P3@32003|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - Ceramidase k59_1260370_1 768671.ThimaDRAFT_4173 3.07e-79 243.0 COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1WX63@135613|Chromatiales 135613|Chromatiales S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_1260370_2 1122201.AUAZ01000008_gene438 3.14e-26 104.0 COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,1S6FG@1236|Gammaproteobacteria,468R1@72275|Alteromonadaceae 1236|Gammaproteobacteria S AMMECR1 - - - ko:K09141 - - - - ko00000 - - - AMMECR1 k59_58928_1 997346.HMPREF9374_1798 1.5e-17 84.7 COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,4H9YV@91061|Bacilli,27AW4@186824|Thermoactinomycetaceae 91061|Bacilli J tRNA synthetases class I (W and Y) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_1154530_1 384676.PSEEN5530 7.01e-112 352.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria I acyl-CoA dehydrogenase - - - ko:K06446 ko00930,ko01100,ko01120,map00930,map01100,map01120 - R06943 RC00052 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_790173_1 1120951.AUBG01000007_gene166 0.000197 47.0 COG0115@1|root,COG0115@2|Bacteria,4NEJY@976|Bacteroidetes,1HY87@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_790173_2 521674.Plim_0771 1.41e-25 103.0 COG0180@1|root,COG0180@2|Bacteria,2IWRB@203682|Planctomycetes 203682|Planctomycetes J Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_475380_1 1255043.TVNIR_0850 6.25e-71 221.0 COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,1RRYZ@1236|Gammaproteobacteria,1WVZM@135613|Chromatiales 135613|Chromatiales C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11,Fer4_7 k59_1363503_2 285535.JOEY01000073_gene9813 6.26e-95 288.0 COG1024@1|root,COG1024@2|Bacteria,2I9QY@201174|Actinobacteria 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - 3.7.1.18 ko:K20765 - - - - ko00000,ko01000 - - - ECH_1 k59_109418_1 383407.XOC_3404 4.35e-98 309.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1X499@135614|Xanthomonadales 135614|Xanthomonadales O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_527542_1 1380394.JADL01000005_gene5444 6.75e-55 195.0 COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2TW4K@28211|Alphaproteobacteria,2JPWC@204441|Rhodospirillales 204441|Rhodospirillales G 4-alpha-glucanotransferase - - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_423254_1 1288494.EBAPG3_28650 1.18e-37 143.0 COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,2VHP6@28216|Betaproteobacteria,371WS@32003|Nitrosomonadales 28216|Betaproteobacteria H TonB-dependent Receptor Plug Domain phuR - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_423254_3 639030.JHVA01000001_gene3146 6.13e-25 102.0 COG0266@1|root,COG0266@2|Bacteria,3Y39U@57723|Acidobacteria,2JI11@204432|Acidobacteriia 204432|Acidobacteriia L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates - - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_1415730_2 1123508.JH636444_gene5649 5.59e-17 79.3 COG1595@1|root,COG1595@2|Bacteria,2J090@203682|Planctomycetes 203682|Planctomycetes K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1260391_1 1121396.KB893112_gene1983 5.5e-32 125.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2MIF7@213118|Desulfobacterales 28221|Deltaproteobacteria U General secretion pathway protein F gspF - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF k59_1260391_2 525897.Dbac_0421 5.56e-13 70.5 COG2203@1|root,COG2804@1|root,COG2203@2|Bacteria,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2M915@213115|Desulfovibrionales 28221|Deltaproteobacteria NU PFAM Type II secretion system protein E gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - GAF,T2SSE,T2SSE_N k59_1468525_2 1288494.EBAPG3_2340 8.36e-40 136.0 COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,2VYD4@28216|Betaproteobacteria,374C6@32003|Nitrosomonadales 28216|Betaproteobacteria S Hydrogenase/urease nickel incorporation, metallochaperone, hypA - - - ko:K04651 - - - - ko00000,ko03110 - - - HypA k59_1468525_3 768671.ThimaDRAFT_2617 8.56e-15 72.4 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RN9Y@1236|Gammaproteobacteria,1WWGI@135613|Chromatiales 135613|Chromatiales KO TIGRFAM Hydrogenase accessory protein HypB - - - ko:K04652 - - - - ko00000,ko03110 - - - cobW k59_1468527_1 196162.Noca_1634 6.14e-29 120.0 COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2GIVI@201174|Actinobacteria,4DND3@85009|Propionibacteriales 201174|Actinobacteria C Xanthine dehydrogenase, molybdenum binding subunit - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2 k59_1415737_1 1469245.JFBG01000007_gene674 1.01e-44 163.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,1X2DA@135613|Chromatiales 135613|Chromatiales S Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_997572_1 744979.R2A130_3536 4.72e-06 47.4 COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2TR02@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_997572_2 196490.AUEZ01000002_gene4255 1.13e-12 76.6 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc,TPR_16,TPR_8 k59_685715_2 161156.JQKW01000008_gene462 4.47e-27 108.0 COG1059@1|root,COG1059@2|Bacteria 2|Bacteria L Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) ogg - 4.2.99.18 ko:K03653 - - - - ko00000,ko01000 - - - - k59_1572169_1 498211.CJA_3194 9.15e-40 148.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1FGCP@10|Cellvibrio 1236|Gammaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0010033,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0031249,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035966,GO:0036094,GO:0042221,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1572169_2 626887.J057_18445 1.63e-12 68.9 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,464KS@72275|Alteromonadaceae 1236|Gammaproteobacteria NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_423276_1 338963.Pcar_2113 3.35e-20 94.4 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,42M77@68525|delta/epsilon subdivisions,2WM41@28221|Deltaproteobacteria,43SS1@69541|Desulfuromonadales 28221|Deltaproteobacteria I Phospholipase D. Active site motifs. - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_423276_2 1123511.KB905840_gene861 2.41e-15 73.6 COG0861@1|root,COG0861@2|Bacteria,1VRPT@1239|Firmicutes,4H76Q@909932|Negativicutes 909932|Negativicutes P Integral membrane protein TerC family - - - - - - - - - - - - TerC k59_1363530_1 118163.Ple7327_2953 6.85e-15 79.3 COG4424@1|root,COG4424@2|Bacteria,1G6NT@1117|Cyanobacteria 1117|Cyanobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_58978_1 1121013.P873_12090 1.64e-52 181.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1X8AF@135614|Xanthomonadales 135614|Xanthomonadales S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_475420_1 445686.E3SL70_9CAUD 4.93e-28 111.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae 10662|Myoviridae S Type III restriction enzyme, res subunit - - - - - - - - - - - - - k59_214253_1 156978.CIMIT_11730 5.97e-69 228.0 COG4638@1|root,COG4638@2|Bacteria,2GP4B@201174|Actinobacteria,22MMB@1653|Corynebacteriaceae 201174|Actinobacteria P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit hcaE_2 - 1.14.12.10,1.14.12.19 ko:K00479,ko:K05549,ko:K05708,ko:K14748 ko00360,ko00362,ko00364,ko00622,ko00642,ko01100,ko01120,ko01220,map00360,map00362,map00364,map00622,map00642,map01100,map01120,map01220 M00545,M00551 R05290,R05291,R05428,R05440,R05621,R05622,R05665,R06782,R06783,R08100,R08101,R08108,R08109,R08110 RC00098,RC00270,RC01378,RC01450,RC01910 br01602,ko00000,ko00001,ko00002,ko01000 - - - Rieske,Ring_hydroxyl_A k59_475423_1 1123261.AXDW01000001_gene1490 1.32e-28 111.0 COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,1X3WT@135614|Xanthomonadales 135614|Xanthomonadales G Sugar kinase VL23_05530 - 2.7.1.20 ko:K00856 ko00230,ko01100,map00230,map01100 - R00185 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_634378_1 426117.M446_2892 4.46e-06 52.8 COG2227@1|root,COG2227@2|Bacteria,1R6NW@1224|Proteobacteria,2U1N3@28211|Alphaproteobacteria,1JURC@119045|Methylobacteriaceae 28211|Alphaproteobacteria H PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_23 k59_841763_1 1089551.KE386572_gene41 8.85e-32 123.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,4BS0N@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q Dienelactone hydrolase family - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_945794_1 330214.NIDE3373 3.89e-18 88.2 COG1262@1|root,COG1262@2|Bacteria 2|Bacteria T PFAM Formylglycine-generating sulfatase enzyme - - - ko:K20333 ko02024,map02024 - - - ko00000,ko00001 - - - FGE-sulfatase,NACHT k59_1625235_1 1415780.JPOG01000001_gene2737 4.5e-24 105.0 COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,1T214@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - DUF3306,Fer4,Fer4_10,Fer4_6,Fer4_7 k59_686453_1 1121374.KB891575_gene1138 4.37e-20 87.0 COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU pilus assembly protein PilN pilN - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_686453_2 472759.Nhal_3889 8.7e-12 64.7 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1WXKR@135613|Chromatiales 135613|Chromatiales NU Pilus assembly protein PilO - - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_319883_1 1357275.AVEL02000109_gene4411 1.05e-63 211.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1Z6HM@136849|Pseudomonas syringae group 1236|Gammaproteobacteria F Bifunctional purine biosynthesis protein PurH purH GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - iEcHS_1320.EcHS_A4240,iPC815.YPO3728 AICARFT_IMPCHas,MGS k59_160802_1 351160.RRC204 5e-42 150.0 COG0265@1|root,arCOG02833@2157|Archaea,2XT7Y@28890|Euryarchaeota,2NAWS@224756|Methanomicrobia 224756|Methanomicrobia O Trypsin - - - - - - - - - - - - PDZ_2,Trypsin_2 k59_3020_1 1124780.ANNU01000006_gene2903 6.45e-34 127.0 COG0398@1|root,COG0398@2|Bacteria,4NIT2@976|Bacteroidetes,47KFE@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function, DUF547 - - - - - - - - - - - - DUF547 k59_319884_1 497964.CfE428DRAFT_1458 5.63e-153 448.0 COG0129@1|root,COG0129@2|Bacteria,46SBY@74201|Verrucomicrobia 74201|Verrucomicrobia EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_790945_1 1304874.JAFY01000002_gene1080 1.85e-48 174.0 COG0367@1|root,COG0367@2|Bacteria 2|Bacteria E asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1209090_1 243231.GSU2224 1.17e-19 96.3 COG0745@1|root,COG0745@2|Bacteria,1N9YT@1224|Proteobacteria,42W15@68525|delta/epsilon subdivisions,2WS2V@28221|Deltaproteobacteria,43T56@69541|Desulfuromonadales 28221|Deltaproteobacteria T regulator, PATAN and FRGAF domain-containing - - - - - - - - - - - - DUF4388,Response_reg k59_1261173_1 1121949.AQXT01000002_gene1122 1.22e-49 171.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TU1G@28211|Alphaproteobacteria,43ZGF@69657|Hyphomonadaceae 28211|Alphaproteobacteria C Alcohol dehydrogenase GroES-like domain MA20_19250 - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_790950_1 911239.CF149_01057 1.96e-07 53.9 2E41E@1|root,32YY1@2|Bacteria,1NGB3@1224|Proteobacteria,1SDTK@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4398) - - - - - - - - - - - - DUF4398 k59_790951_2 485916.Dtox_3816 1.91e-14 73.2 COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,24QQ6@186801|Clostridia,263BK@186807|Peptococcaceae 186801|Clostridia T PFAM Universal stress protein family - - - - - - - - - - - - Usp k59_1572713_1 713586.KB900536_gene1636 1.06e-33 121.0 2BVK0@1|root,32QXS@2|Bacteria,1RKSK@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_267266_1 123214.PERMA_1351 2.93e-67 216.0 COG1633@1|root,COG1814@1|root,COG1633@2|Bacteria,COG1814@2|Bacteria,2G4UT@200783|Aquificae 200783|Aquificae S VIT family - - - - - - - - - - - - Rubrerythrin,VIT1 k59_894229_1 472759.Nhal_3017 1.48e-109 350.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1WX8F@135613|Chromatiales 135613|Chromatiales F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_1050854_2 247634.GPB2148_2933 2.16e-09 58.9 COG4638@1|root,COG4638@2|Bacteria,1PXC0@1224|Proteobacteria,1SM12@1236|Gammaproteobacteria 1236|Gammaproteobacteria P And related ring-hydroxylating dioxygenases, large terminal subunit - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_737231_1 1049564.TevJSym_ca00050 2.92e-70 239.0 COG1033@1|root,COG2834@1|root,COG1033@2|Bacteria,COG2834@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1J96Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M MMPL family VP1286 - - ko:K07003 - - - - ko00000 - - - MMPL k59_1572717_1 1123274.KB899410_gene3492 2.91e-20 95.1 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2J6FV@203691|Spirochaetes 203691|Spirochaetes T Adenylate guanylate cyclase catalytic domain protein - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_1364123_1 999141.GME_05730 1.16e-47 171.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1XHA5@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_1216176_1 1254432.SCE1572_49110 1.71e-30 114.0 COG0639@1|root,COG0639@2|Bacteria,1QQKD@1224|Proteobacteria,43EN6@68525|delta/epsilon subdivisions,2X9QX@28221|Deltaproteobacteria,2YYXC@29|Myxococcales 28221|Deltaproteobacteria T Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos_2 k59_1216176_2 1189619.pgond44_08110 8.7e-55 188.0 COG5276@1|root,COG5276@2|Bacteria,4NDUD@976|Bacteroidetes,1HZ43@117743|Flavobacteriia,4C2D7@83612|Psychroflexus 976|Bacteroidetes S LVIVD repeat - - - - - - - - - - - - CarboxypepD_reg,LVIVD,MAM,TSP_3,fn3 k59_378255_1 321327.CYA_0178 1.32e-139 409.0 COG0044@1|root,COG0044@2|Bacteria,1G2H3@1117|Cyanobacteria,1GYM9@1129|Synechococcus 1117|Cyanobacteria F dihydroorotase pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_273528_1 1123236.KB899386_gene1866 6.24e-65 209.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,465RN@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008033,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016740,GO:0016765,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0033554,GO:0034248,GO:0034470,GO:0034605,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043555,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051716,GO:0052381,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990497,GO:2000112,GO:2000765 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_483538_1 1123393.KB891329_gene1025 2.25e-92 277.0 COG3298@1|root,COG3298@2|Bacteria,1MVZJ@1224|Proteobacteria,2VISP@28216|Betaproteobacteria,1KRCC@119069|Hydrogenophilales 119069|Hydrogenophilales L Predicted 3'-5' exonuclease related to the exonuclease domain of PolB - - - ko:K07501 - - - - ko00000 - - - DNA_pol_B_exo2 k59_743341_1 84531.JMTZ01000081_gene1298 2.07e-84 264.0 COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,1RPN7@1236|Gammaproteobacteria,1X4BQ@135614|Xanthomonadales 135614|Xanthomonadales E peptidase M20 - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_221325_1 1116472.MGMO_15c00320 6.88e-32 119.0 COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,1RNXI@1236|Gammaproteobacteria,1XDPD@135618|Methylococcales 135618|Methylococcales K Response regulator receiver - - - - - - - - - - - - GerE,Response_reg k59_483551_1 1089550.ATTH01000001_gene1570 9.02e-41 148.0 COG1181@1|root,COG1181@2|Bacteria,4PEAY@976|Bacteroidetes,1FIPX@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C k59_273544_1 1177154.Y5S_01713 1.45e-90 299.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,1XI5R@135619|Oceanospirillales 135619|Oceanospirillales S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16 k59_534466_1 1283300.ATXB01000001_gene2242 1.57e-70 222.0 COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,1S6JM@1236|Gammaproteobacteria,1XE76@135618|Methylococcales 135618|Methylococcales S Serine aminopeptidase, S33 - - - - - - - - - - - - Hydrolase_4 k59_67886_1 330214.NIDE2981 3.34e-42 148.0 COG0158@1|root,COG0158@2|Bacteria,3J12X@40117|Nitrospirae 40117|Nitrospirae G Fructose-1-6-bisphosphatase, N-terminal domain - - 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase k59_67886_2 330214.NIDE2982 5.9e-39 137.0 COG3170@1|root,COG3170@2|Bacteria,3J1DA@40117|Nitrospirae 40117|Nitrospirae NU Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 k59_586834_1 1500890.JQNL01000001_gene910 1.23e-23 95.9 COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,1S23N@1236|Gammaproteobacteria,1X3BY@135614|Xanthomonadales 135614|Xanthomonadales K Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C k59_586834_2 472759.Nhal_2759 7.58e-46 153.0 COG4446@1|root,COG4446@2|Bacteria,1N7IZ@1224|Proteobacteria,1SCZH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF1499 k59_799473_1 59374.Fisuc_1628 1.27e-27 109.0 COG0664@1|root,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding - - - ko:K01420,ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_799473_2 1125863.JAFN01000001_gene1639 1.99e-50 177.0 COG0836@1|root,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,42MDP@68525|delta/epsilon subdivisions,2WJEN@28221|Deltaproteobacteria 28221|Deltaproteobacteria M TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase manAC - 2.7.7.13 ko:K00971 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_1109472_1 582744.Msip34_0871 1.48e-92 272.0 COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,2VQ71@28216|Betaproteobacteria,2KM1Q@206350|Nitrosomonadales 206350|Nitrosomonadales I Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length fabA - 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_1109472_2 317025.Tcr_1945 3.97e-15 74.7 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,45ZXJ@72273|Thiotrichales 72273|Thiotrichales IQ Belongs to the beta-ketoacyl-ACP synthases family - - 2.3.1.179,2.3.1.41 ko:K00647,ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_534477_1 323261.Noc_2823 5.04e-24 95.5 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,1WY8C@135613|Chromatiales 135613|Chromatiales J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_534477_2 472759.Nhal_0027 4.51e-57 188.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1WXMZ@135613|Chromatiales 135613|Chromatiales I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_534481_1 701176.VIBRN418_13256 1.25e-55 184.0 COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,1RPYF@1236|Gammaproteobacteria,1XTAW@135623|Vibrionales 135623|Vibrionales P COG1108 ABC-type Mn2 Zn2 transport systems, permease components znuB - - ko:K09816 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_848037_1 1536769.P40081_26335 5.41e-06 48.1 COG0745@1|root,COG0745@2|Bacteria,1TSWT@1239|Firmicutes,4HGB5@91061|Bacilli,26RSX@186822|Paenibacillaceae 91061|Bacilli T Heme response regulator HssR - - - - - - - - - - - - Response_reg,Trans_reg_C k59_848037_2 83406.HDN1F_02500 2.41e-74 226.0 COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,1S0DD@1236|Gammaproteobacteria,1J5PB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Acyl dehydratase nodN - - - - - - - - - - - MaoC_dehydratas k59_848037_3 1030157.AFMP01000031_gene3063 2.27e-109 323.0 COG1028@1|root,COG1028@2|Bacteria,1PGYV@1224|Proteobacteria,2VEVG@28211|Alphaproteobacteria,2K2ZW@204457|Sphingomonadales 204457|Sphingomonadales IQ short-chain dehydrogenase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_273567_1 926564.KI911625_gene4028 5.1e-37 134.0 COG4923@1|root,COG4923@2|Bacteria,2IJP8@201174|Actinobacteria 201174|Actinobacteria K Protein of unknown function (DUF429) - - - - - - - - - - - - DUF429 k59_1578853_1 391937.NA2_14322 2.62e-05 50.4 COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,2UEQ6@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_642553_1 1229780.BN381_210110 1.41e-73 233.0 COG1960@1|root,COG1960@2|Bacteria,2HY6H@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase fadE21 - - ko:K00257 - - R04547,R04592 RC01942 ko00000,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_534491_1 330214.NIDE3200 1.04e-96 291.0 COG1234@1|root,COG1234@2|Bacteria,3J113@40117|Nitrospirae 40117|Nitrospirae S tRNA 3'-trailer cleavage - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - - k59_642554_1 1384056.N787_09565 1.68e-47 173.0 COG1770@1|root,COG1770@2|Bacteria,1MUED@1224|Proteobacteria,1RMSV@1236|Gammaproteobacteria,1X31I@135614|Xanthomonadales 135614|Xanthomonadales E peptidase ptrB - 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_430120_1 349521.HCH_01836 6.27e-71 244.0 COG0501@1|root,COG0501@2|Bacteria,1NA37@1224|Proteobacteria,1RY3D@1236|Gammaproteobacteria,1XNVU@135619|Oceanospirillales 135619|Oceanospirillales O Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_326931_1 460265.Mnod_0142 6.49e-44 157.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,1JTWU@119045|Methylobacteriaceae 28211|Alphaproteobacteria E TIGRFAM asparagine synthase (glutamine-hydrolyzing) asnO - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1270111_1 359.CN09_03510 1.44e-12 75.9 COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria,4BC7V@82115|Rhizobiaceae 28211|Alphaproteobacteria L Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07497 - - - - ko00000 - - - HTH_28,HTH_32,rve,rve_3 k59_1270114_1 1265503.KB905166_gene680 3.26e-67 213.0 COG1597@1|root,COG1597@2|Bacteria,1MY37@1224|Proteobacteria,1RMX9@1236|Gammaproteobacteria 1224|Proteobacteria I the in vivo substrate is - - - - - - - - - - - - DAGK_cat k59_484518_1 582744.Msip34_0531 5.27e-67 216.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2VHSQ@28216|Betaproteobacteria,2KMGQ@206350|Nitrosomonadales 28216|Betaproteobacteria C Cytochrome bd terminal oxidase subunit II cydB - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_1057824_1 225937.HP15_3661 5.99e-32 121.0 292MF@1|root,2ZQ5C@2|Bacteria,1RCYR@1224|Proteobacteria,1S44V@1236|Gammaproteobacteria,46BI2@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3047) - - - - - - - - - - - - DUF3047 k59_379059_1 1051632.TPY_2134 1.84e-06 53.9 COG1215@1|root,COG1215@2|Bacteria,1TSD3@1239|Firmicutes,248YQ@186801|Clostridia 186801|Clostridia M Glycosyl transferase family group 2 - - 2.4.1.12 ko:K00694 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - Cellulose_synt,Glyco_tranf_2_3,Glycos_transf_2,PilZ k59_379059_2 262316.MAP_3619 2.68e-15 82.0 COG3804@1|root,COG3804@2|Bacteria,2GKE3@201174|Actinobacteria,23829@1762|Mycobacteriaceae 201174|Actinobacteria S dihydrodipicolinate reductase - - 1.4.1.12,1.4.1.26 ko:K21672 ko00310,ko00330,ko00472,map00310,map00330,map00472 - R02825,R04200,R04201,R04687,R04688 RC00249,RC00790 ko00000,ko00001,ko01000 - - - DapB_N k59_535054_1 176299.Atu2190 0.000828 43.9 COG0451@1|root,COG0451@2|Bacteria,1MXYR@1224|Proteobacteria,2TT4T@28211|Alphaproteobacteria,4B9P6@82115|Rhizobiaceae 28211|Alphaproteobacteria GM NmrA-like family - - - - - - - - - - - - Epimerase,NAD_binding_10 k59_535054_2 449447.MAE_31780 1.38e-100 306.0 COG4992@1|root,COG4992@2|Bacteria,1G4MC@1117|Cyanobacteria 1117|Cyanobacteria E Aminotransferase class-III - - 2.6.1.13 ko:K00819 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R00667 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_1216723_1 765912.Thimo_2636 9.41e-29 116.0 COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,1RQZJ@1236|Gammaproteobacteria,1WX5R@135613|Chromatiales 135613|Chromatiales I aromatic hydrocarbon degradation - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_1478118_1 1207063.P24_02221 7.43e-99 298.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,2JPG4@204441|Rhodospirillales 204441|Rhodospirillales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_1004979_1 1500893.JQNB01000001_gene361 9e-89 268.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1X38C@135614|Xanthomonadales 135614|Xanthomonadales M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_1004983_1 1124780.ANNU01000006_gene2788 7.23e-40 146.0 COG3693@1|root,COG3693@2|Bacteria,4NE5Z@976|Bacteroidetes,47KU5@768503|Cytophagia 976|Bacteroidetes G PFAM Glycosyl hydrolase family 10 - - 3.2.1.8 ko:K01181 - - - - ko00000,ko01000 - - - Glyco_hydro_10 k59_743970_1 1125863.JAFN01000001_gene1090 1.39e-28 120.0 COG0618@1|root,COG0618@2|Bacteria,1N0JS@1224|Proteobacteria,42P1S@68525|delta/epsilon subdivisions,2WJV0@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM phosphoesterase, RecJ domain protein - - - - - - - - - - - - DHH,DHHA1 k59_1004986_1 247639.MGP2080_00345 1.76e-92 286.0 COG2200@1|root,COG2200@2|Bacteria,1N299@1224|Proteobacteria 1224|Proteobacteria T EAL domain - - - - - - - - - - - - EAL,Response_reg k59_1004986_2 29581.BW37_05245 6.86e-95 288.0 COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,4730X@75682|Oxalobacteraceae 28216|Betaproteobacteria F A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response srkA - - - - - - - - - - - APH k59_800432_1 330214.NIDE0677 1.22e-88 267.0 COG1651@1|root,COG1651@2|Bacteria 2|Bacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process dsbA GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071236,GO:0140096 - ko:K03673 ko01503,map01503 M00728 - - ko00000,ko00001,ko00002,ko03110 - - iEcSMS35_1347.EcSMS35_4241 DSBA k59_274189_1 1493508.A0A0E3FSZ1_9CAUD 4.5e-29 117.0 4QEE7@10239|Viruses,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae 10662|Myoviridae S Pfam:DUF4815 - - - - - - - - - - - - - k59_274189_2 1589733.A0A0C5AMW5_9CAUD 1.28e-18 89.0 4QB1D@10239|Viruses,4QPED@28883|Caudovirales,4QI2Z@10662|Myoviridae 10662|Myoviridae S Bacteriophage T4, Gp8 - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098025 - - - - - - - - - - - k59_1057852_2 2074.JNYD01000048_gene753 4.27e-33 127.0 COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4DZCT@85010|Pseudonocardiales 201174|Actinobacteria Q Belongs to the long-chain O-acyltransferase family tgs3 GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - DUF1298,WES_acyltransf k59_1161074_1 287.DR97_2365 5.01e-67 219.0 COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,1RQE3@1236|Gammaproteobacteria,1YFFJ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Glycosyl transferases group 1 rfaG GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02844 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT4 iSDY_1059.SDY_4061 Glyco_transf_4,Glycos_transf_1 k59_1161074_2 1165096.ARWF01000001_gene846 1.31e-32 124.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,2VHHX@28216|Betaproteobacteria,2KM3T@206350|Nitrosomonadales 206350|Nitrosomonadales M TIGRFAM lipopolysaccharide heptosyltransferase II - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_1317746_1 365046.Rta_01360 2.92e-44 163.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VIAP@28216|Betaproteobacteria,4AJZ4@80864|Comamonadaceae 28216|Betaproteobacteria P ATPases associated with a variety of cellular activities - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1632587_1 1246626.BleG1_2698 2.88e-74 237.0 COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,4H9NS@91061|Bacilli,1ZCF9@1386|Bacillus 91061|Bacilli G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapB GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016491,GO:0016620,GO:0016903,GO:0019318,GO:0019319,GO:0036094,GO:0043891,GO:0044238,GO:0044281,GO:0044283,GO:0046364,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_116941_1 1123368.AUIS01000003_gene1841 1.73e-06 47.4 COG4783@1|root,COG4783@2|Bacteria,1N76P@1224|Proteobacteria,1T4CE@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16 k59_116941_2 190650.CC_3660 9.15e-59 186.0 COG3651@1|root,COG3651@2|Bacteria,1RH68@1224|Proteobacteria,2U9D3@28211|Alphaproteobacteria,2KINW@204458|Caulobacterales 204458|Caulobacterales S Uncharacterized protein conserved in bacteria (DUF2237) - - - ko:K09966 - - - - ko00000 - - - DUF2237 k59_484605_1 1223542.GM1_019_00360 1.95e-57 191.0 COG1735@1|root,COG1735@2|Bacteria,2GMZ6@201174|Actinobacteria,4GC9B@85026|Gordoniaceae 201174|Actinobacteria S Phosphotriesterase family php - - ko:K07048 - - - - ko00000 - - - PTE k59_5995_1 156889.Mmc1_3292 1.31e-157 463.0 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,2TW7V@28211|Alphaproteobacteria 28211|Alphaproteobacteria L PFAM transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_643501_2 1123242.JH636434_gene4996 1.18e-122 356.0 COG1432@1|root,COG1432@2|Bacteria,2IY4C@203682|Planctomycetes 203682|Planctomycetes S OST-HTH/LOTUS domain - - - - - - - - - - - - NYN,OST-HTH k59_744010_1 713586.KB900536_gene354 4.65e-98 306.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1WVYK@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_1216751_1 548477.HMPREF0294_0416 1.17e-66 209.0 COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,22KIT@1653|Corynebacteriaceae 201174|Actinobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_901139_1 1192124.LIG30_3668 4.93e-23 100.0 COG1129@1|root,COG4177@1|root,COG1129@2|Bacteria,COG4177@2|Bacteria,1R9IW@1224|Proteobacteria,2VKMT@28216|Betaproteobacteria,1KIFF@119060|Burkholderiaceae 28216|Betaproteobacteria EG Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_901139_2 706587.Desti_1992 9.94e-15 72.4 COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria 1224|Proteobacteria E amino acid - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_116955_2 686340.Metal_0282 3.03e-72 226.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1XE2A@135618|Methylococcales 135618|Methylococcales C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family - - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_1424664_1 5346.XP_001833053.1 3.69e-33 132.0 COG1025@1|root,KOG0959@2759|Eukaryota,38D2B@33154|Opisthokonta,3NUAC@4751|Fungi,3V026@5204|Basidiomycota,2261U@155619|Agaricomycetes,3W6BW@5338|Agaricales 4751|Fungi O Belongs to the peptidase M16 family STE23 GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0007323,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0010467,GO:0016020,GO:0016787,GO:0019538,GO:0019898,GO:0031136,GO:0031137,GO:0031139,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043900,GO:0043902,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0046999,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051604,GO:0065007,GO:0070011,GO:0071432,GO:0071704,GO:0140096,GO:1901564,GO:2000241,GO:2000243 3.4.24.56 ko:K01408 ko05010,map05010 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C,Peptidase_M16_M k59_1317762_2 1131266.ARWQ01000006_gene235 2.23e-06 48.1 COG2101@1|root,arCOG01764@2157|Archaea,41SZD@651137|Thaumarchaeota 651137|Thaumarchaeota K General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation - - - ko:K03120 ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203 - - - ko00000,ko00001,ko03000,ko03021 - - - TBP k59_952685_1 1410626.JHXB01000001_gene2169 8.94e-24 103.0 COG2206@1|root,COG3292@1|root,COG2206@2|Bacteria,COG3292@2|Bacteria,1UZN2@1239|Firmicutes,25EWN@186801|Clostridia 186801|Clostridia T metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - DUF3369,GAF_2,HAMP,HD,HD_5,PAS_9,Reg_prop,Response_reg,Y_Y_Y,dCache_1 k59_326987_1 1112217.PPL19_14954 7.89e-31 118.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_326987_2 472759.Nhal_0366 4.86e-33 122.0 2DKHM@1|root,309GY@2|Bacteria,1RFJ6@1224|Proteobacteria,1S4EG@1236|Gammaproteobacteria,1X1R5@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_484637_1 649638.Trad_2375 0.000119 43.5 COG0718@1|root,COG0718@2|Bacteria,1WK7U@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_1270228_1 1353531.AZNX01000005_gene3261 6.84e-44 163.0 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2U4F6@28211|Alphaproteobacteria,4BCVF@82115|Rhizobiaceae 28211|Alphaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - Spermine_synth k59_1270228_2 1283300.ATXB01000002_gene3045 1.02e-94 284.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1S2WI@1236|Gammaproteobacteria,1XEYK@135618|Methylococcales 135618|Methylococcales O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_1270228_3 396588.Tgr7_2599 1.04e-36 127.0 2BXG1@1|root,347YM@2|Bacteria,1P06C@1224|Proteobacteria,1SRS0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1064999_1 1121937.AUHJ01000006_gene2437 6.76e-51 169.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,464NM@72275|Alteromonadaceae 1236|Gammaproteobacteria S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1064999_2 501479.ACNW01000062_gene2714 2.98e-30 115.0 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,2TTXZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_493810_3 471881.PROPEN_02005 1.34e-24 98.6 2CWYZ@1|root,32T0P@2|Bacteria,1MZEM@1224|Proteobacteria,1S9HP@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_228656_1 948106.AWZT01000016_gene128 1.37e-26 113.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,2VJGK@28216|Betaproteobacteria,1K2VM@119060|Burkholderiaceae 28216|Betaproteobacteria L TIGRFAM ATP-dependent DNA helicase, RecQ family - - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecQ_Zn_bind k59_281422_1 1194972.MVAC_16550 2.49e-53 194.0 COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,233RN@1762|Mycobacteriaceae 201174|Actinobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1065015_1 1341151.ASZU01000004_gene657 2.57e-43 152.0 COG0306@1|root,COG0306@2|Bacteria,1TQ3D@1239|Firmicutes,4HAPD@91061|Bacilli,27BNU@186824|Thermoactinomycetaceae 91061|Bacilli P Phosphate transporter family pit GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_1065015_2 626418.bglu_1g13990 9.3e-06 47.0 COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,2VKF1@28216|Betaproteobacteria,1K3P4@119060|Burkholderiaceae 28216|Betaproteobacteria P phosphate transport regulator - - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_1166451_1 1229909.NSED_06490 1.73e-70 237.0 COG0060@1|root,arCOG00807@2157|Archaea,41SFF@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family - - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_438557_1 1121106.JQKB01000017_gene4847 4.34e-76 236.0 COG2267@1|root,COG2267@2|Bacteria,1N9CI@1224|Proteobacteria,2UG67@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_493823_1 247634.GPB2148_828 8.63e-67 219.0 COG1757@1|root,COG1757@2|Bacteria,1MY5C@1224|Proteobacteria,1RP6I@1236|Gammaproteobacteria,1J53V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C C4-dicarboxylate anaerobic carrier mleN - - - - - - - - - - - Na_H_antiporter k59_1012077_1 314231.FP2506_13339 2.11e-120 355.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2PKH2@255475|Aurantimonadaceae 28211|Alphaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1012077_2 1458357.BG58_21650 3.76e-23 94.7 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,1K3K2@119060|Burkholderiaceae 28216|Betaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_1377639_1 243233.MCA0647 2.42e-29 117.0 COG1226@1|root,32Y28@2|Bacteria,1NEAT@1224|Proteobacteria,1S588@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Ion channel - - - - - - - - - - - - Ion_trans_2 k59_1377639_2 396588.Tgr7_2598 6.39e-35 130.0 COG0265@1|root,COG0265@2|Bacteria,1R6MU@1224|Proteobacteria,1S181@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Trypsin-like serine protease - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_439599_1 66377.JOBH01000006_gene219 1.97e-16 79.3 COG1024@1|root,COG1024@2|Bacteria,2HEIS@201174|Actinobacteria 201174|Actinobacteria I Enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 k59_439599_2 925409.KI911562_gene187 6.57e-07 54.7 COG1024@1|root,COG1024@2|Bacteria,4NFEM@976|Bacteroidetes,1INKY@117747|Sphingobacteriia 976|Bacteroidetes I Belongs to the enoyl-CoA hydratase isomerase family crt - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_334919_1 1125863.JAFN01000001_gene3058 8.88e-35 135.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKFA@28221|Deltaproteobacteria 68525|delta/epsilon subdivisions T response regulator - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1641900_1 1282876.BAOK01000001_gene1495 4.39e-76 258.0 COG0613@1|root,COG0613@2|Bacteria,1R4N5@1224|Proteobacteria 1224|Proteobacteria S PHP domain protein - - - - - - - - - - - - - k59_1013211_1 477184.KYC_02094 3.76e-12 65.9 COG1414@1|root,COG1853@1|root,COG1414@2|Bacteria,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,2VQA1@28216|Betaproteobacteria,3T4H9@506|Alcaligenaceae 28216|Betaproteobacteria K Flavin reductase like domain ntaB - - - - - - - - - - - Flavin_Reduct,IclR k59_1013211_2 202952.BBLI01000024_gene1923 6.11e-21 89.7 COG1846@1|root,COG1846@2|Bacteria,1RCY7@1224|Proteobacteria,1S49H@1236|Gammaproteobacteria,3NNRE@468|Moraxellaceae 1236|Gammaproteobacteria K helix_turn_helix multiple antibiotic resistance protein hpaR - - - - - - - - - - - MarR k59_495430_1 572477.Alvin_1437 3.01e-113 350.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales 135613|Chromatiales D DNA segregation ATPase FtsK SpoIIIE - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1488869_2 1123393.KB891316_gene1815 4.35e-30 118.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2VIJH@28216|Betaproteobacteria,1KSJU@119069|Hydrogenophilales 119069|Hydrogenophilales P NMT1-like family - - - - - - - - - - - - NMT1_2 k59_811347_1 1121861.KB899925_gene2473 2.28e-55 190.0 COG5476@1|root,COG5476@2|Bacteria,1NS9S@1224|Proteobacteria,2UNYM@28211|Alphaproteobacteria,2JUXX@204441|Rhodospirillales 204441|Rhodospirillales S MlrC C-terminus - - - - - - - - - - - - DUF1485,MlrC_C k59_542727_1 1235457.C404_21575 5.9e-29 122.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,1K0VI@119060|Burkholderiaceae 28216|Betaproteobacteria S Peptidase M48 yggG_1 - - - - - - - - - - - Peptidase_M48,TPR_19 k59_126815_1 318167.Sfri_0951 5.95e-06 48.1 COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,1RR85@1236|Gammaproteobacteria,2QA0V@267890|Shewanellaceae 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrC GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0097159,GO:0097367,GO:1901265,GO:1901363 1.6.5.8 ko:K00348 - - - - ko00000,ko01000 - - - FMN_bind k59_126815_2 305700.B447_16874 2.95e-66 213.0 COG1805@1|root,COG1805@2|Bacteria,1QTUU@1224|Proteobacteria,2VN5U@28216|Betaproteobacteria 28216|Betaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrB - 1.6.5.8 ko:K00347 - - - - ko00000,ko01000 - - - NQR2_RnfD_RnfE k59_229731_1 1348657.M622_02875 1.29e-77 249.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2W9JH@28216|Betaproteobacteria,2KZ4U@206389|Rhodocyclales 206389|Rhodocyclales S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_9891_2 265072.Mfla_1147 8.05e-07 50.8 COG1525@1|root,COG1525@2|Bacteria,1PRMF@1224|Proteobacteria,2VX3N@28216|Betaproteobacteria,2KP7K@206350|Nitrosomonadales 206350|Nitrosomonadales L Staphylococcal nuclease homologues - - - - - - - - - - - - SNase k59_1013238_1 742726.HMPREF9448_02159 5.67e-06 50.8 COG2869@1|root,COG2869@2|Bacteria,4NF7A@976|Bacteroidetes,2FMQM@200643|Bacteroidia,22XWP@171551|Porphyromonadaceae 976|Bacteroidetes C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrC - 1.6.5.8 ko:K00348 - - - - ko00000,ko01000 - - - FMN_bind k59_1013238_2 547045.NEISICOT_00500 3.01e-10 60.5 COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,2VM5K@28216|Betaproteobacteria,2KSGS@206351|Neisseriales 206351|Neisseriales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrD - 1.6.5.8 ko:K00349 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_495468_1 1247649.D560_3828 1.14e-61 201.0 COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,2VN7F@28216|Betaproteobacteria,3T7ZU@506|Alcaligenaceae 28216|Betaproteobacteria L Transposase for IS481 element - - - - - - - - - - - - LZ_Tnp_IS481,rve,rve_3 k59_752018_3 1288494.EBAPG3_23850 1.3e-51 173.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,37215@32003|Nitrosomonadales 28216|Betaproteobacteria I fatty acid desaturase ole1 - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - DDE_Tnp_ISL3,FA_desaturase k59_1281310_1 765911.Thivi_3892 4.54e-65 215.0 COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,1S0CA@1236|Gammaproteobacteria,1WXQT@135613|Chromatiales 135613|Chromatiales L Transposase IS4 family - - - - - - - - - - - - DDE_Tnp_1,DUF4338,Dimer_Tnp_Tn5,Tnp_DNA_bind k59_9892_1 1121346.KB899814_gene1816 1.4e-17 84.0 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,4H9Y8@91061|Bacilli,26R5G@186822|Paenibacillaceae 91061|Bacilli L Participates in initiation and elongation during chromosome replication dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_495473_2 685727.REQ_15580 1.94e-58 200.0 COG0318@1|root,COG0318@2|Bacteria,2GJYP@201174|Actinobacteria,4FVK2@85025|Nocardiaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1488898_1 330214.NIDE2460 1.43e-89 269.0 COG0177@1|root,COG0177@2|Bacteria,3J0K6@40117|Nitrospirae 40117|Nitrospirae L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD k59_1118021_1 330214.NIDE2573 1.03e-72 232.0 COG0151@1|root,COG0151@2|Bacteria,3J0H5@40117|Nitrospirae 40117|Nitrospirae F Phosphoribosylglycinamide synthetase, C domain purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_595513_1 768671.ThimaDRAFT_2470 8.99e-90 272.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1WWP3@135613|Chromatiales 135613|Chromatiales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_1118022_1 1046724.KB889887_gene461 1.53e-21 98.2 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,1RRDQ@1236|Gammaproteobacteria,46495@72275|Alteromonadaceae 1236|Gammaproteobacteria V COG0534 Na -driven multidrug efflux pump VVA1228 - - - - - - - - - - - MatE k59_1435192_1 1123279.ATUS01000001_gene1361 1.07e-20 95.1 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,1RRHA@1236|Gammaproteobacteria,1J643@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_1641975_1 1565314.OA34_12795 9.41e-17 79.3 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2YMDS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Belongs to the aldehyde dehydrogenase family aldB - - ko:K00138 ko00010,ko00620,ko01100,ko01110,ko01120,map00010,map00620,map01100,map01110,map01120 - R00711 RC00047 ko00000,ko00001,ko01000 - - - Aldedh k59_1641975_2 1123242.JH636436_gene382 2.2e-05 48.1 COG3829@1|root,COG3829@2|Bacteria,2IYAF@203682|Planctomycetes 203682|Planctomycetes KT GAF domain - - - - - - - - - - - - GAF,HTH_8,Sigma54_activat k59_1118031_2 1408444.JHYC01000020_gene212 4.94e-47 162.0 COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,1RQNF@1236|Gammaproteobacteria,1JDG1@118969|Legionellales 118969|Legionellales L Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_857011_1 395493.BegalDRAFT_0738 4.97e-47 165.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,45ZZX@72273|Thiotrichales 72273|Thiotrichales T response regulator receiver - - - - - - - - - - - - DUF229,HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat k59_9899_1 1121405.dsmv_1463 4.33e-125 384.0 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,42P3Z@68525|delta/epsilon subdivisions,2WKRN@28221|Deltaproteobacteria,2MJ14@213118|Desulfobacterales 28221|Deltaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain - - 1.5.3.1 ko:K00302 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - Fer2_4,Fer2_BFD,GCV_T,GCV_T_C,Pyr_redox_2 k59_229759_1 234267.Acid_0272 3.75e-29 120.0 COG0367@1|root,COG0367@2|Bacteria,3Y75N@57723|Acidobacteria 57723|Acidobacteria E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1378719_1 985255.APHJ01000054_gene2016 4.89e-23 99.0 COG0277@1|root,COG0277@2|Bacteria,4NHFC@976|Bacteroidetes,1HYJ4@117743|Flavobacteriia,2P79G@244698|Gillisia 976|Bacteroidetes C Berberine and berberine like - - - - - - - - - - - - BBE,DUF805,FAD_binding_4 k59_857017_2 62928.azo3816 4.42e-50 170.0 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2VSS5@28216|Betaproteobacteria,2KZV5@206389|Rhodocyclales 28216|Betaproteobacteria K AraC family transcriptional regulator - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_811405_1 1255043.TVNIR_3599 5.56e-45 157.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1WX83@135613|Chromatiales 135613|Chromatiales S PFAM YicC-like - - - - - - - - - - - - DUF1732,YicC_N k59_1488930_1 323261.Noc_3041 2.01e-13 70.5 COG1999@1|root,COG1999@2|Bacteria,1N6R6@1224|Proteobacteria 1224|Proteobacteria S signal sequence binding VVA1110 - - - - - - - - - - - - k59_1488930_2 1122599.AUGR01000001_gene160 4.79e-24 100.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,1XI1Y@135619|Oceanospirillales 135619|Oceanospirillales O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group cyoE - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_334988_1 316067.Geob_0980 6.33e-32 129.0 COG1305@1|root,COG1305@2|Bacteria,1PEH8@1224|Proteobacteria 1224|Proteobacteria E Transglutaminase-like - - - - - - - - - - - - Transglut_core k59_542777_1 1123367.C666_05880 1.93e-39 142.0 COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,2VI8U@28216|Betaproteobacteria 28216|Betaproteobacteria HP Abc transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran,Mg_chelatase k59_229776_1 331869.BAL199_24044 1.17e-131 396.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,4BR7T@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782,ko:K07516 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04743,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1529168_1 242159.ABP00607 4.01e-17 82.8 2D2NJ@1|root,2S4YP@2759|Eukaryota 2759|Eukaryota S NAD dependent epimerase/dehydratase family - - - - - - - - - - - - Epimerase k59_1529168_2 29176.XP_003883660.1 8.26e-12 67.4 COG3914@1|root,KOG4626@2759|Eukaryota,3YB6K@5794|Apicomplexa,3YN6Y@5796|Coccidia,3YQYD@5809|Sarcocystidae 5794|Apicomplexa GOT Glycosyl transferase family 41 - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_10,TPR_17,TPR_8 k59_654307_1 105559.Nwat_1202 2.95e-174 506.0 COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,1S118@1236|Gammaproteobacteria,1X0F2@135613|Chromatiales 135613|Chromatiales I Squalene-hopene cyclase N-terminal domain - - 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 - R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 - - - SQHop_cyclase_C,SQHop_cyclase_N k59_542788_1 314285.KT71_02682 9.85e-56 189.0 COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,1T3IW@1236|Gammaproteobacteria,1J8JS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1 k59_960388_1 506534.Rhein_1903 9.02e-15 80.9 COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,1RMWB@1236|Gammaproteobacteria,1WXW1@135613|Chromatiales 135613|Chromatiales P Iron permease FTR1 - - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - Cytochrome_CBB3,FTR1 k59_811435_1 444860.E3SJ08_9CAUD 7.73e-89 276.0 4QBAK@10239|Viruses,4QY34@35237|dsDNA viruses no RNA stage,4QQBQ@28883|Caudovirales,4QIQI@10662|Myoviridae 10662|Myoviridae S Bacteriophage T4-like capsid assembly protein (Gp20) - GO:0005575,GO:0019012 - - - - - - - - - - - k59_495550_1 99598.Cal7507_1092 1.67e-80 248.0 COG0788@1|root,COG0788@2|Bacteria,1G0SN@1117|Cyanobacteria,1HK5T@1161|Nostocales 1117|Cyanobacteria F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,Formyl_trans_N k59_1225791_1 876044.IMCC3088_1265 1.06e-107 328.0 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria 1236|Gammaproteobacteria E alanine symporter - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_857050_1 358220.C380_02960 5.43e-95 286.0 COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2VJCK@28216|Betaproteobacteria,4A9UI@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Glyoxalase bleomycin resistance protein dioxygenase hppD - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Glyoxalase,Glyoxalase_5 k59_1225797_2 123214.PERMA_1351 1.48e-25 106.0 COG1633@1|root,COG1814@1|root,COG1633@2|Bacteria,COG1814@2|Bacteria,2G4UT@200783|Aquificae 200783|Aquificae S VIT family - - - - - - - - - - - - Rubrerythrin,VIT1 k59_389316_1 519989.ECTPHS_00660 1.03e-99 318.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QUWB@1224|Proteobacteria,1T23G@1236|Gammaproteobacteria,1X2J6@135613|Chromatiales 135613|Chromatiales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_439732_1 1094557.ME3_00178 1.45e-09 65.5 COG0642@1|root,COG2205@2|Bacteria,1MVY8@1224|Proteobacteria,2TS5B@28211|Alphaproteobacteria,48TEK@772|Bartonellaceae 28211|Alphaproteobacteria T GHKL domain divL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - HATPase_c,HisKA,PAS_7,PAS_8 k59_811457_1 794903.OPIT5_20685 5.15e-33 128.0 COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,46UY4@74201|Verrucomicrobia,3K7AN@414999|Opitutae 414999|Opitutae K Hypothetical methyltransferase - - - - - - - - - - - - HTH_5,Methyltransf_11 k59_752103_1 78245.Xaut_0551 7.44e-86 264.0 COG2856@1|root,COG2856@2|Bacteria,1RAU7@1224|Proteobacteria,2TU1W@28211|Alphaproteobacteria 28211|Alphaproteobacteria E IrrE N-terminal-like domain - - - - - - - - - - - - Peptidase_M78 k59_1225815_1 1229909.NSED_09170 3.23e-62 199.0 COG0500@1|root,arCOG04347@2157|Archaea,41T35@651137|Thaumarchaeota 651137|Thaumarchaeota Q Nodulation protein S (NodS) - - - - - - - - - - - - - k59_1489004_1 479434.Sthe_1091 4.73e-130 389.0 COG0296@1|root,COG0296@2|Bacteria,2G5IR@200795|Chloroflexi,27XZS@189775|Thermomicrobia 189775|Thermomicrobia G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_506333_1 765914.ThisiDRAFT_2159 2.52e-65 214.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales 135613|Chromatiales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_709822_1 504832.OCAR_4498 3.08e-32 124.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TQYV@28211|Alphaproteobacteria,3JS31@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Belongs to the beta-ketoacyl-ACP synthases family fabB GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_343926_1 1191523.MROS_0856 1.31e-54 175.0 COG2606@1|root,COG2606@2|Bacteria 2|Bacteria S Cys-tRNA(Pro) hydrolase activity - - - ko:K03976,ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_1235946_1 1122135.KB893140_gene1318 2.9e-69 227.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TR1V@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Dehydrogenase nuoEF - 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_237754_1 314345.SPV1_05704 7.06e-11 69.7 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria 1224|Proteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1330643_1 1146883.BLASA_4994 5.01e-208 592.0 COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4ERW2@85013|Frankiales 201174|Actinobacteria G SMART alpha amylase, catalytic sub domain - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - Alpha-amylase,DUF3459 k59_1330645_1 1122197.ATWI01000008_gene3243 2.96e-12 65.9 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,46577@72275|Alteromonadaceae 1236|Gammaproteobacteria F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004017,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006412,GO:0006518,GO:0006629,GO:0006644,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0010467,GO:0015949,GO:0015950,GO:0015951,GO:0016070,GO:0016208,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019205,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - iECH74115_1262.ECH74115_0566,iEKO11_1354.EKO11_3373,iG2583_1286.G2583_0586,iJN746.PP_1506 ADK,ADK_lid k59_1235962_1 1009858.BUMPG002_CDS00081 2.88e-13 66.2 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,1S8VX@1236|Gammaproteobacteria,37DBH@32199|Buchnera 1236|Gammaproteobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_1235962_2 582744.Msip34_0304 2.23e-66 209.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2VHSD@28216|Betaproteobacteria,2KM4M@206350|Nitrosomonadales 206350|Nitrosomonadales J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_665295_1 1094980.Mpsy_0698 4.62e-89 281.0 COG0058@1|root,arCOG01421@2157|Archaea,2XV8J@28890|Euryarchaeota,2NACZ@224756|Methanomicrobia 224756|Methanomicrobia G PFAM glycosyl transferase, family 35 - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_759858_1 1085623.GNIT_2020 8.88e-05 47.4 COG2755@1|root,COG2755@2|Bacteria,1R43M@1224|Proteobacteria,1RRTK@1236|Gammaproteobacteria,465MH@72275|Alteromonadaceae 1236|Gammaproteobacteria E lipolytic protein G-D-S-L family - - - - - - - - - - - - Lipase_GDSL_2 k59_759858_2 41431.PCC8801_3454 1.27e-23 90.1 2EGPU@1|root,33AFZ@2|Bacteria,1G9QJ@1117|Cyanobacteria,3KISQ@43988|Cyanothece 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_822354_1 67281.JNZZ01000015_gene6552 4.21e-35 125.0 COG0663@1|root,COG0663@2|Bacteria,2GP22@201174|Actinobacteria,419XY@629295|Streptomyces griseus group 201174|Actinobacteria S Bacterial transferase hexapeptide (six repeats) - - - - - - - - - - - - Hexapep,Hexapep_2 k59_1021095_2 1123508.JH636441_gene3468 1.87e-10 61.6 COG2189@1|root,COG2189@2|Bacteria,2IWRP@203682|Planctomycetes 203682|Planctomycetes L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_396111_1 706587.Desti_1073 3.96e-26 110.0 COG1012@1|root,COG1012@2|Bacteria,1MV2I@1224|Proteobacteria,42R7M@68525|delta/epsilon subdivisions,2WMUH@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Succinylglutamic semialdehyde dehydrogenase astD - 1.2.1.71 ko:K06447 ko00330,ko01100,map00330,map01100 - R05049 RC00080 ko00000,ko00001,ko01000 - - - Aldedh k59_90367_1 161156.JQKW01000007_gene859 3.27e-53 181.0 COG0019@1|root,COG0019@2|Bacteria,2GHHY@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_343971_1 1429916.X566_22755 9e-53 177.0 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TUHP@28211|Alphaproteobacteria,3JRVY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family MA20_35605 - - - - - - - - - - - adh_short k59_1536037_2 425400.LS65_08335 2.74e-12 67.8 COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,42RJM@68525|delta/epsilon subdivisions,2YP5P@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S protein conserved in bacteria - - - ko:K09778 - - - - ko00000 - - - DUF374 k59_1595571_1 1123399.AQVE01000002_gene2386 1.58e-05 53.9 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,461EP@72273|Thiotrichales 72273|Thiotrichales T Methyl-accepting chemotaxis protein (MCP) signaling domain - - - - - - - - - - - - HAMP,MCPsignal k59_1595571_2 1123401.JHYQ01000045_gene3367 1.05e-146 428.0 COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,1RS1M@1236|Gammaproteobacteria,462NJ@72273|Thiotrichales 72273|Thiotrichales E PFAM Receptor family ligand binding region - - - - - - - - - - - - Peripla_BP_6 k59_291803_1 1410620.SHLA_40c000420 4.57e-11 65.5 COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,2TR17@28211|Alphaproteobacteria,4B9EG@82115|Rhizobiaceae 28211|Alphaproteobacteria V ABC-type protease lipase transport system, ATPase and permease components prsD - - ko:K06148 - - - - ko00000,ko02000 3.A.1 - - ABC_membrane,ABC_tran k59_1653062_2 1049564.TevJSym_ar00240 8.22e-08 55.8 COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,1RMYN@1236|Gammaproteobacteria,1J5R9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - Peptidase_M23 k59_1499856_1 330214.NIDE1591 4.85e-99 297.0 COG3359@1|root,COG3359@2|Bacteria,3J137@40117|Nitrospirae 40117|Nitrospirae L RNase_H superfamily - - - ko:K07502 - - - - ko00000 - - - RNase_H_2 k59_1499856_2 1444712.BN1013_01702 6.24e-09 56.6 COG0631@1|root,COG0631@2|Bacteria,2JG4D@204428|Chlamydiae 204428|Chlamydiae T Serine threonine protein phosphatase prpC - 3.1.3.16 ko:K01090,ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 k59_1499858_1 1192034.CAP_6602 7.64e-71 231.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WKB4@28221|Deltaproteobacteria,2YTUD@29|Myxococcales 28221|Deltaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4,Fer4_20,Pyr_redox_2 k59_709890_1 1120792.JAFV01000001_gene1051 7.55e-88 273.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2TSD1@28211|Alphaproteobacteria,36X4A@31993|Methylocystaceae 28211|Alphaproteobacteria I 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal dxr GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_1386100_1 1122194.AUHU01000008_gene3413 8.14e-05 44.3 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria,4677N@72275|Alteromonadaceae 1236|Gammaproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate tsaC GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061710,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC k59_1386100_2 998088.B565_3805 9.17e-23 92.8 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria,1Y48K@135624|Aeromonadales 135624|Aeromonadales F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) - - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_396147_1 1485545.JQLW01000006_gene350 3.76e-34 129.0 COG1985@1|root,COG1985@2|Bacteria,1RDMT@1224|Proteobacteria 1224|Proteobacteria H RibD C-terminal domain - - - - - - - - - - - - RibD_C k59_396152_1 1121405.dsmv_2119 9.83e-24 105.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MIDR@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-3 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1174405_1 472759.Nhal_1241 9.37e-100 308.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1WWHQ@135613|Chromatiales 135613|Chromatiales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_1174407_1 1121918.ARWE01000001_gene2505 1.41e-78 255.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,42YX3@68525|delta/epsilon subdivisions,2WTY2@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Phosphoenolpyruvate phosphomutase - - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_237828_1 861299.J421_3420 5.86e-87 274.0 COG0539@1|root,COG0539@2|Bacteria,1ZSKI@142182|Gemmatimonadetes 142182|Gemmatimonadetes J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_665377_1 1267005.KB911255_gene2830 2.08e-44 166.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria 28211|Alphaproteobacteria H receptor - - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_1386123_1 1229909.NSED_09670 6.92e-64 212.0 COG0652@1|root,arCOG04767@2157|Archaea,41T0W@651137|Thaumarchaeota 651137|Thaumarchaeota O Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_1021157_1 1125863.JAFN01000001_gene366 1.84e-42 155.0 COG0768@1|root,COG0768@2|Bacteria,1R7A0@1224|Proteobacteria,42MJC@68525|delta/epsilon subdivisions,2WJZ2@28221|Deltaproteobacteria 28221|Deltaproteobacteria M penicillin-binding protein pbp4 - - - - - - - - - - - Transpeptidase k59_603360_1 1144325.PMI22_03703 4.8e-53 182.0 COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,1RQA2@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - HTH_23,HTH_24,rve k59_1653128_1 1122134.KB893650_gene852 6.47e-74 230.0 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,1RMW5@1236|Gammaproteobacteria,1XI5A@135619|Oceanospirillales 135619|Oceanospirillales P Plays a role in the regulation of phosphate uptake phoU - - ko:K02039 - - - - ko00000 - - - PhoU k59_1653128_2 1283284.AZUK01000001_gene421 7.68e-08 52.4 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,1Y3VS@135624|Aeromonadales 135624|Aeromonadales P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_1536100_1 323261.Noc_0510 4.18e-65 213.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1WX0A@135613|Chromatiales 135613|Chromatiales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_1536100_2 396588.Tgr7_0522 6.77e-27 108.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1WXFU@135613|Chromatiales 135613|Chromatiales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_865023_1 1411685.U062_01222 2.15e-86 293.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,1J5BG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_237859_1 1123487.KB892867_gene1012 1.54e-103 323.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,2KV8K@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_1536105_1 105559.Nwat_0625 7.09e-104 311.0 COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,1RQWC@1236|Gammaproteobacteria,1WWH8@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0229 family - - - ko:K09786 - - - - ko00000 - - - DUF444 k59_1292398_1 1137269.AZWL01000008_gene4758 5.65e-08 59.3 COG0438@1|root,COG4424@1|root,COG0438@2|Bacteria,COG4424@2|Bacteria,2HYF0@201174|Actinobacteria 201174|Actinobacteria M Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_291897_1 481448.Minf_1259 1.09e-44 154.0 COG0406@1|root,COG0406@2|Bacteria,46T4J@74201|Verrucomicrobia,37GSS@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia G Phosphoglycerate mutase family phoE - - - - - - - - - - - His_Phos_1 k59_90500_1 436308.Nmar_1790 2.88e-166 475.0 COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM glutamine synthetase, type I - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_1174434_1 290397.Adeh_1905 1.7e-89 268.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,437B2@68525|delta/epsilon subdivisions,2X2FR@28221|Deltaproteobacteria,2Z0QW@29|Myxococcales 28221|Deltaproteobacteria L HNH endonuclease - - - - - - - - - - - - HNH_5 k59_1174434_2 862908.BMS_2873 5.08e-62 206.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,42R3H@68525|delta/epsilon subdivisions,2MTYJ@213481|Bdellovibrionales,2WMNY@28221|Deltaproteobacteria 213481|Bdellovibrionales D CobQ CobB MinD ParA nucleotide binding - - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,CbiA,HTH_25,ParA k59_1174434_3 404589.Anae109_1956 1.8e-13 70.9 COG0484@1|root,COG1426@1|root,COG0484@2|Bacteria,COG1426@2|Bacteria 2|Bacteria S sequence-specific DNA binding - - - - - - - - - - - - DnaJ,HTH_25,TPR_14 k59_918867_1 243231.GSU1593 4.45e-73 240.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,43TFC@69541|Desulfuromonadales 28221|Deltaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_506525_1 1469245.JFBG01000065_gene122 7e-11 62.4 COG1863@1|root,COG1863@2|Bacteria,1MZYJ@1224|Proteobacteria,1S7Z3@1236|Gammaproteobacteria,1X25W@135613|Chromatiales 135613|Chromatiales P Na+/H+ ion antiporter subunit - - - ko:K05569 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MNHE k59_1595658_1 396588.Tgr7_0340 2.31e-112 348.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1RQK9@1236|Gammaproteobacteria,1WWPF@135613|Chromatiales 135613|Chromatiales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.6 ko:K21307 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1499954_1 1167006.UWK_02000 1.01e-14 78.6 COG1216@1|root,COG1216@2|Bacteria,1PFY9@1224|Proteobacteria,437C1@68525|delta/epsilon subdivisions,2XA0C@28221|Deltaproteobacteria,2MPDT@213118|Desulfobacterales 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_91749_1 330214.NIDE0359 8.88e-20 85.1 COG0594@1|root,COG0594@2|Bacteria 2|Bacteria J ribonuclease P activity rnpA GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 ko:K03536,ko:K08998 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_91749_2 999141.GME_04242 5.92e-27 108.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1XIK3@135619|Oceanospirillales 135619|Oceanospirillales J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_1596567_1 246197.MXAN_2832 1.21e-74 233.0 COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,42PYZ@68525|delta/epsilon subdivisions,2WK4B@28221|Deltaproteobacteria,2YUCX@29|Myxococcales 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02050,ko:K15599 ko02010,map02010 M00188,M00442 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.17,3.A.1.17.3,3.A.1.17.6 - - BPD_transp_1 k59_604201_1 330214.NIDE0940 4.58e-68 213.0 COG3764@1|root,COG3764@2|Bacteria 2|Bacteria M Sortase family srtA - 3.4.22.70 ko:K07284 - - - - ko00000,ko01000,ko01002,ko01011 - - - Sortase k59_1175330_1 1268237.G114_08285 4.79e-34 124.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,1Y3WI@135624|Aeromonadales 135624|Aeromonadales J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_1175330_2 991.IW20_22995 2.85e-06 48.5 COG1192@1|root,COG1192@2|Bacteria,4NFEX@976|Bacteroidetes,1HXYG@117743|Flavobacteriia,2NTM9@237|Flavobacterium 976|Bacteroidetes D Chromosome partitioning protein ParA soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_397089_1 411483.FAEPRAA2165_02660 3.73e-57 195.0 COG0004@1|root,COG0347@1|root,COG0004@2|Bacteria,COG0347@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,3WH0N@541000|Ruminococcaceae 186801|Clostridia P Belongs to the P(II) protein family - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp,P-II k59_760830_1 309801.trd_A0838 7.77e-12 67.8 COG2146@1|root,COG3369@1|root,COG2146@2|Bacteria,COG3369@2|Bacteria,2G7AG@200795|Chloroflexi,27YM0@189775|Thermomicrobia 189775|Thermomicrobia P Rieske-like [2Fe-2S] domain - - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske k59_1128797_1 309807.SRU_2216 7.04e-32 125.0 COG0002@1|root,COG0002@2|Bacteria,4NEQR@976|Bacteroidetes,1FK0Z@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1596577_2 998674.ATTE01000001_gene207 1.22e-124 368.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,45ZRY@72273|Thiotrichales 72273|Thiotrichales E TIGRFAM glutamine synthetase, type I glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_182039_1 1123320.KB889566_gene5764 4.3e-73 246.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,2GKBW@201174|Actinobacteria 201174|Actinobacteria C indolepyruvate ferredoxin oxidoreductase - - 1.2.7.8 ko:K00179,ko:K04090 - - - - br01601,ko00000,ko01000 - - - Fer4,POR,POR_N,TPP_enzyme_C k59_188939_1 452637.Oter_4221 4.23e-11 68.2 COG2211@1|root,COG2211@2|Bacteria,46YMU@74201|Verrucomicrobia,3K7KX@414999|Opitutae 414999|Opitutae G MFS/sugar transport protein - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_301592_1 1269813.ATUL01000008_gene1511 4.47e-131 383.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_301592_2 395493.BegalDRAFT_1884 1.34e-11 67.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,45ZUB@72273|Thiotrichales 72273|Thiotrichales C NADH-quinone oxidoreductase nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1452201_1 1250006.JHZZ01000001_gene1789 0.000684 48.1 COG0784@1|root,COG2202@1|root,COG3829@1|root,COG4585@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4585@2|Bacteria,4NG0M@976|Bacteroidetes,1HWM9@117743|Flavobacteriia,3VX2E@52959|Polaribacter 976|Bacteroidetes T Histidine kinase narQ - - - - - - - - - - - HATPase_c,HisKA_3,PAS_9,PilJ k59_1393641_1 330214.NIDE1825 7.77e-49 160.0 COG1502@1|root,COG1502@2|Bacteria,3J1DV@40117|Nitrospirae 40117|Nitrospirae I PLD-like domain - - - - - - - - - - - - PLDc_2 k59_1393641_2 330214.NIDE1826 2.26e-34 128.0 COG0654@1|root,COG0654@2|Bacteria,3J16C@40117|Nitrospirae 40117|Nitrospirae C FAD binding domain - - - - - - - - - - - - FAD_binding_3 k59_873189_1 558884.JRGM01000150_gene3530 3.13e-14 72.4 COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1S90Z@1236|Gammaproteobacteria,1Y619@135624|Aeromonadales 135624|Aeromonadales C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrom_C k59_458963_1 1121035.AUCH01000003_gene1256 2.36e-74 230.0 COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,2VI8M@28216|Betaproteobacteria,2KV5F@206389|Rhodocyclales 206389|Rhodocyclales C Prokaryotic cytochrome b561 - - - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Ni_hydr_CYTB k59_718683_1 266835.14022537 3.49e-08 59.7 COG1028@1|root,COG1028@2|Bacteria,1MXE0@1224|Proteobacteria,2U1P2@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Dehydrogenase - - - - - - - - - - - - adh_short_C2 k59_301615_1 525897.Dbac_2750 1.63e-70 219.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2WJGN@28221|Deltaproteobacteria,2M894@213115|Desulfovibrionales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_677554_1 1282876.BAOK01000001_gene1038 3.23e-06 47.8 COG0730@1|root,COG0730@2|Bacteria,1MVY3@1224|Proteobacteria,2TU6M@28211|Alphaproteobacteria,4BQEX@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_677554_2 314345.SPV1_06084 4.2e-44 150.0 COG5587@1|root,COG5587@2|Bacteria,1R8B4@1224|Proteobacteria 1224|Proteobacteria S PFAM conserved - - - - - - - - - - - - DUF2461 k59_1338270_1 1219076.N646_1566 1.64e-05 46.6 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1XVI5@135623|Vibrionales 135623|Vibrionales J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_1245069_1 398767.Glov_2832 4.53e-97 292.0 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,42P58@68525|delta/epsilon subdivisions,2WKYK@28221|Deltaproteobacteria,43TAQ@69541|Desulfuromonadales 28221|Deltaproteobacteria M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_0547 Asp_Glu_race k59_404091_1 1198232.CYCME_1776 1.71e-09 58.2 COG0515@1|root,COG0631@1|root,COG0515@2|Bacteria,COG0631@2|Bacteria,1MV1P@1224|Proteobacteria,1RNQN@1236|Gammaproteobacteria,4603S@72273|Thiotrichales 72273|Thiotrichales KLT Serine/threonine phosphatases, family 2C, catalytic domain - - - - - - - - - - - - PP2C_2,Pkinase k59_404091_2 413404.Rmag_0687 1.14e-47 166.0 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,1RP5H@1236|Gammaproteobacteria,1J8E0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG2223 Nitrate nitrite transporter - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1,Sugar_tr k59_1245070_1 395963.Bind_3264 4.54e-13 69.3 COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2TRMH@28211|Alphaproteobacteria,3N9YE@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Histidine-specific methyltransferase, SAM-dependent - - - - - - - - - - - - Methyltransf_33 k59_1245070_2 1121405.dsmv_3020 7.89e-26 97.8 2E9MH@1|root,333U5@2|Bacteria,1NDRZ@1224|Proteobacteria,42VYW@68525|delta/epsilon subdivisions,2WR91@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_834681_1 948565.AFFP02000006_gene229 4.3e-31 121.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1Y7RE@135625|Pasteurellales 135625|Pasteurellales C fumarate reductase, flavoprotein subunit frdA GO:0000104,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0022900,GO:0032991,GO:0044237,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803 1.3.5.4 ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1543916_1 1288494.EBAPG3_26850 1.62e-43 159.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,371M3@32003|Nitrosomonadales 28216|Betaproteobacteria E extracellular solute-binding protein, family 5 oppA - - - - - - - - - - - SBP_bac_5 k59_1543916_2 305900.GV64_12470 4.47e-05 44.7 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1XMA6@135619|Oceanospirillales 135619|Oceanospirillales P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1085191_1 1122134.KB893650_gene1037 4.66e-56 179.0 COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,1XJ86@135619|Oceanospirillales 135619|Oceanospirillales I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_1085191_2 1282356.H045_03210 2.91e-19 89.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1YP92@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria I Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - ic_1306.c0216 Hexapep,Hexapep_2,LpxD k59_1085192_1 1121405.dsmv_2454 2.26e-07 58.2 COG2199@1|root,COG3706@2|Bacteria,1RGSE@1224|Proteobacteria,42S8P@68525|delta/epsilon subdivisions,2WNZ9@28221|Deltaproteobacteria,2MJYC@213118|Desulfobacterales 28221|Deltaproteobacteria T diguanylate cyclase - - 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,PAS_9,Response_reg k59_1543931_1 1307761.L21SP2_1349 1.51e-22 96.7 COG0811@1|root,COG0811@2|Bacteria,2J700@203691|Spirochaetes 203691|Spirochaetes U MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_1512073_1 1089550.ATTH01000001_gene1477 1.05e-49 178.0 COG5276@1|root,COG5276@2|Bacteria,4NDUD@976|Bacteroidetes,1FIMC@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S repeat protein - - - - - - - - - - - - CarboxypepD_reg,LVIVD,MAM,TSP_3,fn3 k59_1543940_1 1121920.AUAU01000007_gene519 8.54e-29 115.0 COG0187@1|root,COG0187@2|Bacteria,3Y369@57723|Acidobacteria 57723|Acidobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1543940_2 553184.ATORI0001_1258 3.62e-23 99.8 COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4CU8E@84998|Coriobacteriia 84998|Coriobacteriia L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_718736_1 177437.HRM2_38480 8.62e-83 258.0 COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,42NTX@68525|delta/epsilon subdivisions,2WMFG@28221|Deltaproteobacteria 28221|Deltaproteobacteria E sarcosine oxidase - - - - - - - - - - - - DAO k59_1512087_1 290397.Adeh_0625 8.52e-26 112.0 COG3852@1|root,COG3852@2|Bacteria,1QVPN@1224|Proteobacteria,42PS3@68525|delta/epsilon subdivisions,2X7MQ@28221|Deltaproteobacteria,2YVCB@29|Myxococcales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS,PAS_8 k59_928693_1 1128421.JAGA01000001_gene2005 3.93e-50 180.0 COG3280@1|root,COG3280@2|Bacteria 2|Bacteria G synthase treY GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Alpha-amylase,Glyco_hydro_77 k59_677629_1 1123399.AQVE01000004_gene2618 1.47e-20 95.5 COG1716@1|root,COG3456@1|root,COG1716@2|Bacteria,COG3456@2|Bacteria,1R3R7@1224|Proteobacteria,1S0GX@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Type VI secretion fha1 - - ko:K07169,ko:K11894,ko:K11913 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko02044 3.A.23.1 - - FHA k59_246716_1 243231.GSU0331 2.41e-85 269.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,43UDA@69541|Desulfuromonadales 28221|Deltaproteobacteria M PFAM peptidase S1 and S6, chymotrypsin Hap degP - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_518694_1 926569.ANT_26910 1.89e-28 119.0 COG0596@1|root,COG0596@2|Bacteria,2G6Y2@200795|Chloroflexi 200795|Chloroflexi I PFAM alpha beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_301684_1 86106.I862_06525 7.68e-05 52.8 COG1287@1|root,COG1287@2|Bacteria,1N1IK@1224|Proteobacteria,2U2U7@28211|Alphaproteobacteria 28211|Alphaproteobacteria S oligosaccharyl transferase activity - - - - - - - - - - - - - k59_1452273_1 1229909.NSED_06830 6.25e-60 203.0 COG4257@1|root,arCOG03564@2157|Archaea,41SM7@651137|Thaumarchaeota 651137|Thaumarchaeota V antibiotic catabolic process - - - ko:K18235 - - - - ko00000,ko01000,ko01504 - - - - k59_873269_1 397945.Aave_3235 3.15e-71 226.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2VJUU@28216|Betaproteobacteria,4ABJY@80864|Comamonadaceae 28216|Betaproteobacteria K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form cobB - - - - - - - - - - - SIR2 k59_1665480_1 713586.KB900536_gene1717 1.8e-22 88.6 COG3785@1|root,COG3785@2|Bacteria,1RGWN@1224|Proteobacteria,1S62D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress hspQ - - ko:K11940 - - - - ko00000,ko03036 - - - YccV-like k59_1665480_2 62928.azo2062 3.2e-08 56.2 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,2VQA2@28216|Betaproteobacteria,2KW5U@206389|Rhodocyclales 206389|Rhodocyclales O FKBP-type peptidyl-prolyl cis-trans slyD - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_1393711_1 745411.B3C1_18411 7.59e-45 154.0 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1J5SC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048519,GO:0050789,GO:0051186,GO:0051188,GO:0051604,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - iECSF_1327.ECSF_0569,iSFV_1184.SFV_0696,iSFxv_1172.SFxv_0718 BPL_LplA_LipB k59_145882_1 679926.Mpet_0522 1.1e-81 262.0 COG0500@1|root,arCOG01791@2157|Archaea,2XZTQ@28890|Euryarchaeota,2NAGP@224756|Methanomicrobia 224756|Methanomicrobia Q Methyltransferase domain - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Methyltransf_25 k59_1304612_1 5061.CADANGAP00007398 0.000845 47.4 COG2319@1|root,KOG0263@2759|Eukaryota,39JXU@33154|Opisthokonta,3Q4A8@4751|Fungi,3RMGC@4890|Ascomycota,20KUN@147545|Eurotiomycetes 4751|Fungi K WD domain, G-beta repeat - - - - - - - - - - - - NACHT,WD40 k59_301694_2 670487.Ocepr_2069 8.63e-31 118.0 COG2998@1|root,COG2998@2|Bacteria,1WJKH@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H PBP superfamily domain - - - ko:K05772 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - PBP_like_2 k59_1085249_1 671143.DAMO_0872 3.08e-104 309.0 COG2267@1|root,COG2267@2|Bacteria,2NRR1@2323|unclassified Bacteria 2|Bacteria I Alpha/beta hydrolase family - - 3.1.1.24 ko:K01055 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00568 R02991 RC00825 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1 k59_611144_1 314230.DSM3645_17365 1.85e-23 103.0 COG1092@1|root,COG1092@2|Bacteria,2IWV1@203682|Planctomycetes 203682|Planctomycetes J (SAM)-dependent - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_1029734_1 1121935.AQXX01000122_gene5683 2.64e-35 131.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1XH4R@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_1512164_2 880073.Calab_1229 9.03e-06 48.9 COG0526@1|root,COG0526@2|Bacteria,2NPYK@2323|unclassified Bacteria 2|Bacteria O Thioredoxin-like resA - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA,Thioredoxin_8 k59_1304662_1 1123399.AQVE01000011_gene1230 2.21e-35 129.0 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,1RQRT@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Xanthine and CO dehydrogenases maturation factor XdhC CoxF family xdhC2 - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_834821_1 1265505.ATUG01000003_gene585 4.86e-155 452.0 COG1960@1|root,COG1960@2|Bacteria,1R15B@1224|Proteobacteria,42MUT@68525|delta/epsilon subdivisions,2WJ8T@28221|Deltaproteobacteria,2MI3E@213118|Desulfobacterales 28221|Deltaproteobacteria C acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_1452308_1 1123288.SOV_3c09450 3.78e-13 75.1 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H35F@909932|Negativicutes 909932|Negativicutes NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_301728_1 626887.J057_18130 4.27e-76 241.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,4643J@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_1029744_1 1283300.ATXB01000001_gene1419 2.48e-44 159.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,1RQ8J@1236|Gammaproteobacteria,1XFN6@135618|Methylococcales 135618|Methylococcales M Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1304667_1 444860.E3SJA1_9CAUD 1.35e-32 127.0 4QCVH@10239|Viruses,4QVG6@35237|dsDNA viruses no RNA stage 10239|Viruses S transferase activity - - - - - - - - - - - - - k59_1338369_1 330214.NIDE3591 1.38e-61 209.0 COG0744@1|root,COG0744@2|Bacteria,3J1FP@40117|Nitrospirae 40117|Nitrospirae M Transglycosylase - - 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_101554_2 227377.CBU_0099 1.47e-28 110.0 COG2062@1|root,COG2062@2|Bacteria,1RGWQ@1224|Proteobacteria,1S9W7@1236|Gammaproteobacteria,1JEYS@118969|Legionellales 118969|Legionellales T Histidine phosphatase superfamily (branch 1) sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_190297_1 278963.ATWD01000002_gene506 2.02e-08 58.9 COG1215@1|root,COG1215@2|Bacteria,3Y2GM@57723|Acidobacteria,2JI7F@204432|Acidobacteriia 204432|Acidobacteriia M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 k59_190297_2 1230476.C207_00264 1.76e-20 89.0 COG0111@1|root,COG0111@2|Bacteria,1MW0R@1224|Proteobacteria,2TWC9@28211|Alphaproteobacteria,3JVP3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_769306_1 1121939.L861_00505 2.06e-38 137.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1XIUA@135619|Oceanospirillales 135619|Oceanospirillales S Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_1086405_2 436308.Nmar_1198 4.36e-56 186.0 COG0585@1|root,arCOG04252@2157|Archaea,41S7C@651137|Thaumarchaeota 651137|Thaumarchaeota J tRNA pseudouridine synthase - - 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_929969_1 745014.OMB55_00020080 1.96e-127 383.0 COG1520@1|root,COG1520@2|Bacteria,1R8EB@1224|Proteobacteria,1SN3M@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - k59_247868_1 330214.NIDE3908 9.25e-119 346.0 COG1127@1|root,COG1127@2|Bacteria,3J0J2@40117|Nitrospirae 2|Bacteria Q ABC transporter iamA - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_247868_2 330214.NIDE3907 4.87e-50 167.0 COG1463@1|root,COG1463@2|Bacteria 2|Bacteria Q ABC-type transport system involved in resistance to organic solvents, periplasmic component iamC - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_1453369_1 1397666.RS24_01114 1.24e-41 150.0 COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2TVBB@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1394741_1 1235279.C772_03038 1.71e-15 81.3 COG2366@1|root,COG2366@2|Bacteria,1UFHA@1239|Firmicutes,4HACM@91061|Bacilli,26EP7@186818|Planococcaceae 91061|Bacilli S Penicillin acylase acyII - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_247876_1 243231.GSU0485 1.29e-07 55.1 COG3222@1|root,COG3222@2|Bacteria,1RHCP@1224|Proteobacteria,43B9I@68525|delta/epsilon subdivisions,2X6NN@28221|Deltaproteobacteria,43SK2@69541|Desulfuromonadales 28221|Deltaproteobacteria S Guanylyl transferase CofC like - - - ko:K09931 - - - - ko00000 - - - DUF2064 k59_1183175_1 330214.NIDE2199 1.16e-54 186.0 COG2206@1|root,COG2206@2|Bacteria,3J14V@40117|Nitrospirae 40117|Nitrospirae T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - DUF3391,HD k59_1183175_2 330214.NIDE2197 4.45e-13 67.4 COG2825@1|root,COG2825@2|Bacteria,3J1AH@40117|Nitrospirae 40117|Nitrospirae M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K06142 - - - - ko00000 - - - OmpH k59_874463_1 1298880.AUEV01000004_gene1915 2.21e-09 60.1 COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria 201174|Actinobacteria C FAD linked agpS - 2.5.1.26 ko:K00803 ko00565,ko01100,ko04146,map00565,map01100,map04146 - R04311 RC00020,RC02886 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_874463_2 1155718.KB891889_gene6874 5.28e-53 177.0 COG2141@1|root,COG2141@2|Bacteria,2GJTP@201174|Actinobacteria 201174|Actinobacteria C F420-dependent oxidoreductase - - - - - - - - - - - - Bac_luciferase k59_929998_1 1121405.dsmv_2047 9.54e-38 138.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MG3@68525|delta/epsilon subdivisions,2WKC7@28221|Deltaproteobacteria,2MJDD@213118|Desulfobacterales 28221|Deltaproteobacteria Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE,STAS_2 k59_929998_2 1049564.TevJSym_ad01540 3.36e-20 85.9 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1J5PY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q E COG1126 ABC-type polar amino acid transport system, ATPase component - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_936781_1 1128421.JAGA01000002_gene1496 2.16e-55 185.0 COG3875@1|root,COG3875@2|Bacteria 2|Bacteria S lactate racemase activity - - 5.1.2.1 ko:K22373 ko00620,map00620 - R01450 RC00519 ko00000,ko00001,ko01000 - - - DUF2088 k59_1401264_1 765914.ThisiDRAFT_1267 5.38e-20 94.4 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1WWF6@135613|Chromatiales 135613|Chromatiales M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_412735_1 998674.ATTE01000001_gene2518 1.38e-112 337.0 COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,461R6@72273|Thiotrichales 72273|Thiotrichales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway nqrF - 1.6.5.8 ko:K00351 - - - - ko00000,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_725933_2 555778.Hneap_0770 2.34e-38 130.0 COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,1S5WU@1236|Gammaproteobacteria,1WYVE@135613|Chromatiales 135613|Chromatiales S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_725935_1 1121403.AUCV01000036_gene2934 2.92e-45 160.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,2MICK@213118|Desulfobacterales 28221|Deltaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_619825_1 298654.FraEuI1c_2843 1.8e-05 47.0 COG2159@1|root,COG2159@2|Bacteria,2GKAB@201174|Actinobacteria,4ETXR@85013|Frankiales 201174|Actinobacteria S PFAM Amidohydrolase 2 - - - - - - - - - - - - Amidohydro_2 k59_1093255_1 2002.JOEQ01000009_gene6528 1.69e-17 87.8 COG2311@1|root,COG2311@2|Bacteria,2GQ7S@201174|Actinobacteria,4EMTM@85012|Streptosporangiales 201174|Actinobacteria S Protein of unknown function (DUF418) - - - ko:K07148 - - - - ko00000 - - - DUF418 k59_1189676_1 497965.Cyan7822_1369 2.96e-22 103.0 COG0745@1|root,COG2202@1|root,COG2203@1|root,COG3829@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1GHFQ@1117|Cyanobacteria,3KKU4@43988|Cyanothece 1117|Cyanobacteria T Histidine kinase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_566834_1 118163.Ple7327_3133 1.37e-52 180.0 COG0530@1|root,COG0530@2|Bacteria,1G1Y9@1117|Cyanobacteria,3VJ8Y@52604|Pleurocapsales 1117|Cyanobacteria P Sodium/calcium exchanger protein ecm27 - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_983497_1 1229909.NSED_09625 1.27e-35 126.0 arCOG08041@1|root,arCOG08041@2157|Archaea,41SRT@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - HTH_27 k59_983497_2 1229909.NSED_09620 7.43e-13 63.9 arCOG08806@1|root,arCOG08806@2157|Archaea,41SUU@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1459892_1 557598.LHK_00996 7.12e-88 263.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,2KQ51@206351|Neisseriales 206351|Neisseriales C subunit II ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_361516_1 876044.IMCC3088_634 2.2e-32 115.0 COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria 1224|Proteobacteria L COG2963, Transposase and inactivated derivatives - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_361516_2 883078.HMPREF9695_00465 9.97e-85 259.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,3JS1E@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L leucine-zipper of insertion element IS481 - - 2.7.7.49 ko:K00986,ko:K07497 - - - - ko00000,ko01000 - - - HTH_32,rve k59_1093292_1 2340.JV46_08820 1.45e-48 162.0 2DS2H@1|root,33E82@2|Bacteria,1NPEB@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_253950_1 1120936.KB907210_gene5519 2.34e-66 211.0 COG2141@1|root,COG2141@2|Bacteria,2GMMJ@201174|Actinobacteria,4EGKE@85012|Streptosporangiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_197833_2 351348.Maqu_2581 3.97e-132 385.0 COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,1RPTN@1236|Gammaproteobacteria,4647V@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - 2.4.1.266 ko:K13693 - - - - ko00000,ko01000,ko01003 - GT81 - - k59_309711_2 118168.MC7420_253 1.92e-13 71.2 COG5285@1|root,COG5285@2|Bacteria,1G5BN@1117|Cyanobacteria,1HARI@1150|Oscillatoriales 1117|Cyanobacteria C COG5285 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - 1.14.11.46 ko:K21195 ko00440,map00440 - R10724 RC01107 ko00000,ko00001,ko01000 - - - PhyH k59_775066_1 996637.SGM_3705 3.44e-21 93.6 COG0220@1|root,COG0220@2|Bacteria,2GJ8R@201174|Actinobacteria 201174|Actinobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_1459919_1 760568.Desku_2885 4.68e-109 327.0 COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,260XK@186807|Peptococcaceae 186801|Clostridia CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_309724_1 316067.Geob_1002 1.96e-78 254.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2WINJ@28221|Deltaproteobacteria,43UFT@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_983545_1 90814.KL370892_gene1958 8.18e-41 142.0 COG1596@1|root,COG1596@2|Bacteria,1MXYS@1224|Proteobacteria,1SC60@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG1596 Periplasmic protein involved in polysaccharide export gumB - - ko:K20988 ko05111,map05111 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB k59_153703_2 68194.JNXR01000016_gene7486 6.95e-09 54.3 COG1141@1|root,COG1141@2|Bacteria 2|Bacteria C electron transfer activity - - - ko:K05337 - - - - ko00000 - - - Fer4_13,Fer4_15 k59_153703_3 1030157.AFMP01000031_gene2904 8.33e-22 93.6 COG1309@1|root,COG1309@2|Bacteria,1NM2A@1224|Proteobacteria,2VE44@28211|Alphaproteobacteria,2K3MQ@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial regulatory proteins, tetR family - - - ko:K09017 - - - - ko00000,ko03000 - - - TetR_N k59_412825_1 105559.Nwat_0795 7.69e-69 220.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1WW7C@135613|Chromatiales 135613|Chromatiales E Belongs to the aspartokinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_1552351_1 436308.Nmar_0193 8.38e-79 249.0 COG0527@1|root,arCOG00861@2157|Archaea,41SFK@651137|Thaumarchaeota 651137|Thaumarchaeota E Amino acid kinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_412833_1 80637.XP_007773763.1 3.64e-05 51.2 KOG0271@1|root,KOG0271@2759|Eukaryota,3AGU6@33154|Opisthokonta,3Q4J3@4751|Fungi,3V7B1@5204|Basidiomycota,22FCW@155619|Agaricomycetes 4751|Fungi U WD40 repeat-like protein - - - ko:K14855 - - - - ko00000,ko03009 - - - NACHT,WD40 k59_1608551_2 436308.Nmar_0018 7.12e-39 132.0 arCOG08804@1|root,arCOG08804@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1146561_1 1265490.JHVY01000005_gene1386 5.25e-40 143.0 COG2885@1|root,COG2885@2|Bacteria,1REH1@1224|Proteobacteria,1S139@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the ompA family - - - - - - - - - - - - DUF4398,OmpA k59_197898_1 314278.NB231_15308 9.31e-62 197.0 COG0566@1|root,COG0566@2|Bacteria,1MWBE@1224|Proteobacteria,1RMPR@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA trmH GO:0001510,GO:0002128,GO:0002938,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008175,GO:0008757,GO:0009020,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0106050,GO:0140098,GO:0140101,GO:1901360 2.1.1.34 ko:K00556 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylas_C,SpoU_methylase k59_983583_1 323848.Nmul_A1119 1.53e-84 266.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,372E5@32003|Nitrosomonadales 28216|Betaproteobacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_153736_1 1535422.ND16A_0740 2.84e-120 357.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,2Q7EB@267889|Colwelliaceae 1236|Gammaproteobacteria P PFAM sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_880530_1 1038862.KB893847_gene5947 2.17e-49 175.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2U37P@28211|Alphaproteobacteria,3JXAU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - TPR_8,Trans_reg_C k59_199703_1 1122194.AUHU01000004_gene1236 3.52e-20 85.9 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,1S63J@1236|Gammaproteobacteria,467BR@72275|Alteromonadaceae 1236|Gammaproteobacteria H COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase folK GO:0000287,GO:0003674,GO:0003824,GO:0003848,GO:0005488,GO:0016740,GO:0016772,GO:0016778,GO:0043167,GO:0043169,GO:0046872 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iECDH1ME8569_1439.ECDH1ME8569_0136,iEcDH1_1363.EcDH1_3460,iJN746.PP_4698,iSBO_1134.SBO_0131 HPPK k59_199703_2 247634.GPB2148_1074 6.7e-13 72.4 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004652,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006276,GO:0006378,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0031124,GO:0034641,GO:0043170,GO:0043412,GO:0043631,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_938614_1 1071679.BG57_25890 1.44e-23 106.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,1K1R9@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_727455_1 1408224.SAMCCGM7_c4032 3.93e-47 172.0 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,4B81Q@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_311495_1 313606.M23134_04205 1.41e-28 118.0 COG1404@1|root,COG1404@2|Bacteria,4PM4C@976|Bacteroidetes,47KZM@768503|Cytophagia 976|Bacteroidetes O Subtilase family - - - - - - - - - - - - Peptidase_S8,fn3 k59_468946_1 1121403.AUCV01000020_gene3115 6.42e-95 296.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,42MGS@68525|delta/epsilon subdivisions,2WJ1K@28221|Deltaproteobacteria,2MINV@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_1609971_1 1229909.NSED_08810 2.2e-65 206.0 COG1422@1|root,arCOG02673@2157|Archaea,41SNR@651137|Thaumarchaeota 651137|Thaumarchaeota U membrane - - - - - - - - - - - - DUF106 k59_938635_1 1123257.AUFV01000003_gene1066 5.11e-166 506.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1X465@135614|Xanthomonadales 135614|Xanthomonadales E Glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1403190_1 266117.Rxyl_3202 1.51e-63 216.0 COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,4CPVB@84995|Rubrobacteria 84995|Rubrobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_414682_1 237368.SCABRO_01870 1.77e-112 345.0 COG0043@1|root,COG0043@2|Bacteria,2IYCA@203682|Planctomycetes 203682|Planctomycetes H COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and - - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_155298_1 861299.J421_0146 1.74e-42 152.0 COG1090@1|root,COG1090@2|Bacteria,1ZTIF@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF1731) - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase k59_468976_1 1168065.DOK_04688 3.53e-83 251.0 COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,1RRRU@1236|Gammaproteobacteria,1J5MZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0560 Phosphoserine phosphatase thrH - 2.7.1.39,3.1.3.3 ko:K02203 ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230 M00018 R00582,R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD,Hydrolase k59_199784_1 926556.Echvi_0902 1.33e-10 67.0 COG1807@1|root,COG1807@2|Bacteria,4NKI5@976|Bacteroidetes,47XJQ@768503|Cytophagia 976|Bacteroidetes M Dolichyl-phosphate-mannose-protein mannosyltransferase arnT - - - - - - - - - - - PMT_2 k59_938662_1 5145.XP_001912510.1 8.66e-08 58.2 28XSC@1|root,2R4JR@2759|Eukaryota,38CC2@33154|Opisthokonta,3NY61@4751|Fungi,3QRZK@4890|Ascomycota,2159A@147550|Sordariomycetes,3U5WY@5139|Sordariales 4751|Fungi E Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_985492_2 247634.GPB2148_1808 1.54e-47 165.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria 1236|Gammaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine - - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - DUF1989,GCV_T,GCV_T_C k59_568440_2 1380386.JIAW01000027_gene7119 6.89e-93 283.0 COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria,237RH@1762|Mycobacteriaceae 201174|Actinobacteria S Oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_155326_2 257310.BB2488 7.52e-21 93.6 COG0154@1|root,COG0154@2|Bacteria,1MWWQ@1224|Proteobacteria,2VKHW@28216|Betaproteobacteria,3T6D8@506|Alcaligenaceae 28216|Betaproteobacteria J Belongs to the amidase family - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_1347917_1 1384054.N790_08745 1.61e-45 162.0 COG3975@1|root,COG3975@2|Bacteria,1QX25@1224|Proteobacteria,1RWD8@1236|Gammaproteobacteria,1X9T6@135614|Xanthomonadales 135614|Xanthomonadales S protease with the C-terminal PDZ domain - - - - - - - - - - - - - k59_727511_2 686340.Metal_1012 2.55e-45 160.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1XE4R@135618|Methylococcales 135618|Methylococcales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_469008_1 1121403.AUCV01000043_gene108 1.16e-27 113.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42MQS@68525|delta/epsilon subdivisions,2WINP@28221|Deltaproteobacteria,2MPXR@213118|Desulfobacterales 28221|Deltaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 ko:K01782,ko:K01825 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_469008_2 1049564.TevJSym_bc00270 8.35e-53 179.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,1J4GS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the thiolase family pcaF - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_414739_1 1121878.AUGL01000001_gene174 1.19e-40 146.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria 1236|Gammaproteobacteria P antiporter yrbG GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005262,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006816,GO:0006873,GO:0006874,GO:0006875,GO:0008150,GO:0008273,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015081,GO:0015085,GO:0015267,GO:0015291,GO:0015297,GO:0015298,GO:0015318,GO:0015368,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0019725,GO:0022803,GO:0022804,GO:0022821,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030955,GO:0031224,GO:0031226,GO:0031402,GO:0031420,GO:0034220,GO:0035725,GO:0042592,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070588,GO:0070838,GO:0071804,GO:0071805,GO:0071944,GO:0072503,GO:0072507,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516 - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - iAPECO1_1312.APECO1_3239,iECABU_c1320.ECABU_c36110,iECNA114_1301.ECNA114_3275,iECOK1_1307.ECOK1_3617,iECS88_1305.ECS88_3578,iECSF_1327.ECSF_3028,iUMN146_1321.UM146_00400,iUTI89_1310.UTI89_C3632,ic_1306.c3956 Na_Ca_ex k59_621896_1 1121127.JAFA01000043_gene4191 3.08e-38 140.0 COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,2VMXT@28216|Betaproteobacteria,1K33I@119060|Burkholderiaceae 28216|Betaproteobacteria S paraquat-inducible protein A pqiA - - ko:K03808 - - - - ko00000 - - - PqiA k59_1461930_2 1453503.AU05_12950 8.95e-29 106.0 COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,1SDIM@1236|Gammaproteobacteria,1YGGJ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria J CRS1_YhbY yhbY GO:0000027,GO:0000028,GO:0000966,GO:0000967,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0034470,GO:0034471,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0042274,GO:0043021,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1990275 - ko:K07574 - - - - ko00000,ko03009 - - - CRS1_YhbY k59_1461930_3 1122962.AULH01000007_gene1977 0.00046 42.4 COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,2TSBW@28211|Alphaproteobacteria,36XU7@31993|Methylocystaceae 28211|Alphaproteobacteria J FtsJ-like methyltransferase ftsJ - 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_1038433_1 330214.NIDE3294 1.53e-61 200.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 k59_106736_1 1279038.KB907338_gene979 4.46e-41 147.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRI1@28211|Alphaproteobacteria,2JQVU@204441|Rhodospirillales 204441|Rhodospirillales I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_106736_2 388739.RSK20926_22419 3.17e-41 150.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2P25M@2433|Roseobacter 28211|Alphaproteobacteria I COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit pccA - 6.4.1.3 ko:K01965 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1151566_1 1191299.AJYX01000115_gene27 1.65e-58 191.0 COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,1RNVI@1236|Gammaproteobacteria,1XU77@135623|Vibrionales 135623|Vibrionales F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism - - 3.5.4.2 ko:K21053 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase k59_524942_1 330214.NIDE0605 1.33e-34 120.0 COG0713@1|root,COG0713@2|Bacteria,3J0SN@40117|Nitrospirae 40117|Nitrospirae C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_524942_2 330214.NIDE0606 3.13e-22 92.8 COG0839@1|root,COG0839@2|Bacteria,3J0RP@40117|Nitrospirae 40117|Nitrospirae C Belongs to the complex I subunit 6 family - - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_472311_1 1192034.CAP_5717 1.01e-10 67.8 COG2270@1|root,COG2270@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - - ko:K08162,ko:K08226,ko:K16211 - - - - ko00000,ko02000 2.A.1.2.21,2.A.1.41,2.A.2.6 - - MFS_1,PUCC k59_682301_1 1535422.ND16A_0036 1.68e-30 112.0 2DN04@1|root,32UP0@2|Bacteria,1N3MR@1224|Proteobacteria,1SARX@1236|Gammaproteobacteria,2Q89Y@267889|Colwelliaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_682301_2 568076.XP_007821022.1 4.12e-10 63.2 COG1228@1|root,2QRDE@2759|Eukaryota,38P80@33154|Opisthokonta,3NXY9@4751|Fungi,3QKFZ@4890|Ascomycota,2166X@147550|Sordariomycetes,3TCNY@5125|Hypocreales,3G6HD@34397|Clavicipitaceae 4751|Fungi G Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_838415_1 338963.Pcar_2145 3.38e-11 64.7 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43UCF@69541|Desulfuromonadales 28221|Deltaproteobacteria T response regulator pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_682306_1 2711.XP_006490510.1 1.41e-06 50.1 COG0069@1|root,KOG0399@2759|Eukaryota,37RTT@33090|Viridiplantae,3G7BE@35493|Streptophyta 35493|Streptophyta E glutamate synthase GLT1 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009719,GO:0009725,GO:0009735,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0015930,GO:0016040,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0032502,GO:0040007,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045181,GO:0046394,GO:0046686,GO:0048589,GO:0050896,GO:0055114,GO:0060359,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901698 1.4.1.13,1.4.1.14 ko:K00264 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,GATase_2,GXGXG,Glu_syn_central,Glu_synthase,Pyr_redox_2 k59_682306_2 928724.SacglDRAFT_00931 4.44e-62 204.0 COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,4DYTC@85010|Pseudonocardiales 201174|Actinobacteria E NADH NADPH, small subunit gltD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iNJ661.Rv3858c Fer4_20,Pyr_redox_2 k59_942565_1 29581.BW37_02111 7.27e-07 50.1 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2VR66@28216|Betaproteobacteria,474KC@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Type II secretion system (T2SS), protein G gspG2 - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_942565_2 264462.Bd1595 1.11e-25 106.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2MUP1@213481|Bdellovibrionales,2WJE0@28221|Deltaproteobacteria 213481|Bdellovibrionales U General secretion pathway protein F gspF - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF k59_1412666_1 439235.Dalk_5049 7.99e-46 159.0 COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,42QRA@68525|delta/epsilon subdivisions,2WN1V@28221|Deltaproteobacteria,2MK22@213118|Desulfobacterales 28221|Deltaproteobacteria S Metallo-beta-lactamase superfamily - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - Lactamase_B k59_1099703_1 338963.Pcar_1271 5.21e-70 221.0 COG0463@1|root,COG0463@2|Bacteria,1MW2G@1224|Proteobacteria,43BKJ@68525|delta/epsilon subdivisions,2WIZJ@28221|Deltaproteobacteria,43U4H@69541|Desulfuromonadales 28221|Deltaproteobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_733965_1 1288494.EBAPG3_25860 3.32e-54 181.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2VJA4@28216|Betaproteobacteria,37234@32003|Nitrosomonadales 28216|Betaproteobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_1465388_1 1235457.C404_27930 9.93e-70 219.0 COG1024@1|root,COG1024@2|Bacteria,1PSRK@1224|Proteobacteria,2VKV4@28216|Betaproteobacteria,1K365@119060|Burkholderiaceae 28216|Betaproteobacteria I enoyl-CoA hydratase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1465388_2 1218074.BAXZ01000011_gene2700 0.000177 43.9 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2VIQT@28216|Betaproteobacteria,1JZSR@119060|Burkholderiaceae 28216|Betaproteobacteria C acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_577084_1 338963.Pcar_1385 8.68e-59 193.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria,43TYM@69541|Desulfuromonadales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_786723_1 316274.Haur_0795 3.6e-19 89.0 COG0318@1|root,COG0318@2|Bacteria 2|Bacteria IQ PFAM AMP-dependent synthetase and ligase - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,LuxE k59_786723_2 682795.AciX8_1960 3.67e-48 171.0 COG0160@1|root,COG0160@2|Bacteria,3Y3P2@57723|Acidobacteria,2JIZJ@204432|Acidobacteriia 204432|Acidobacteriia E Aminotransferase class-III - - 2.6.1.19 ko:K00823 ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_55468_1 335543.Sfum_0899 1.64e-62 210.0 COG0490@1|root,COG0569@1|root,COG1226@1|root,COG0490@2|Bacteria,COG0569@2|Bacteria,COG1226@2|Bacteria,1R4J8@1224|Proteobacteria,42NKU@68525|delta/epsilon subdivisions,2WIRH@28221|Deltaproteobacteria,2MRD0@213462|Syntrophobacterales 28221|Deltaproteobacteria P Ion channel - - - - - - - - - - - - Ion_trans_2,TrkA_C,TrkA_N k59_55468_2 1033802.SSPSH_000293 6.27e-12 65.9 COG3555@1|root,COG3555@2|Bacteria,1MW3M@1224|Proteobacteria,1RN80@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Aspartyl Asparaginyl beta-hydroxylase - - - ko:K12979 - - - - ko00000,ko01000,ko01005 - - - Asp_Arg_Hydrox k59_1412672_1 265072.Mfla_2071 2.6e-44 163.0 COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,2VJ4Z@28216|Betaproteobacteria,2KM8F@206350|Nitrosomonadales 206350|Nitrosomonadales P TrkA-N domain - - - - - - - - - - - - Ion_trans_2,TrkA_N k59_1621968_1 330214.NIDE0789 1.68e-45 150.0 COG0360@1|root,COG0360@2|Bacteria,3J0VS@40117|Nitrospirae 40117|Nitrospirae J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_106756_1 861299.J421_2864 4.97e-66 213.0 COG2133@1|root,COG2133@2|Bacteria 2|Bacteria G pyrroloquinoline quinone binding - - - - - - - - - - - - CBM_2,GSDH k59_786731_1 1121439.dsat_0513 4.96e-18 86.3 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,42P77@68525|delta/epsilon subdivisions,2WK7E@28221|Deltaproteobacteria,2M7ZP@213115|Desulfovibrionales 28221|Deltaproteobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_682327_2 69279.BG36_09610 7.04e-113 343.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TS14@28211|Alphaproteobacteria,43IAX@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E ABC-type dipeptide transport system periplasmic component MA20_19540 - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1412684_1 395493.BegalDRAFT_1564 0.000192 43.5 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,460EP@72273|Thiotrichales 72273|Thiotrichales G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1048184_1 243233.MCA2173 7.35e-108 328.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - MacB_PCD k59_1048184_2 290400.Jann_3111 4.92e-13 69.7 COG0803@1|root,COG0803@2|Bacteria,1RAQU@1224|Proteobacteria,2UQPU@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Zinc-uptake complex component A periplasmic - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_943381_1 1123320.KB889697_gene8968 1.05e-20 93.2 COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria 201174|Actinobacteria Q cytochrome P450 - - 1.14.13.141 ko:K15981 ko00984,ko01120,map00984,map01120 - R09859,R11357 RC01216,RC03368 ko00000,ko00001,ko00199,ko01000 - - - p450 k59_1100535_1 1160137.KB907307_gene2825 2.39e-32 121.0 COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4FX1Q@85025|Nocardiaceae 201174|Actinobacteria I Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1100535_2 525368.HMPREF0591_4539 1.66e-51 178.0 COG1960@1|root,COG1960@2|Bacteria,2HQGI@201174|Actinobacteria,2335V@1762|Mycobacteriaceae 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1 k59_473187_1 103733.JNYO01000002_gene500 1.24e-16 78.2 COG2128@1|root,COG2128@2|Bacteria,2I829@201174|Actinobacteria,4E36F@85010|Pseudonocardiales 201174|Actinobacteria S carboxymuconolactone decarboxylase - - - ko:K07486 - - - - ko00000 - - - CMD k59_683287_1 713586.KB900536_gene2526 1.68e-115 335.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1WX43@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_1517167_1 1469245.JFBG01000027_gene1473 3.5e-50 173.0 COG1012@1|root,COG1012@2|Bacteria,1QUBI@1224|Proteobacteria,1T3J1@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG1012 NAD-dependent aldehyde dehydrogenases - - 1.1.1.1,1.2.1.10,1.2.1.87 ko:K04072,ko:K13922 ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00640,map00650,map01100,map01110,map01120,map01130,map01220 - R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927,R09097 RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195 ko00000,ko00001,ko01000 - - - Aldedh k59_1517167_2 1207063.P24_05444 1.37e-46 160.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,2JQE6@204441|Rhodospirillales 204441|Rhodospirillales E Pyridoxal-phosphate dependent enzyme - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1257842_1 1266998.ATUJ01000005_gene1177 2.47e-13 69.3 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2TQKR@28211|Alphaproteobacteria,2PU7Y@265|Paracoccus 28211|Alphaproteobacteria G Ribulose-phosphate 3 epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_1257842_2 1408473.JHXO01000005_gene1502 2.15e-105 323.0 COG0364@1|root,COG0364@2|Bacteria,4NE59@976|Bacteroidetes,2FNER@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_943385_1 1049564.TevJSym_ab00410 8.13e-96 301.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1J50Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0659 Sulfate permease and related transporters (MFS superfamily) - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,STAS_2,Sulfate_transp k59_525739_1 444860.E3SJ18_9CAUD 6.28e-298 816.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae 10662|Myoviridae S Type III restriction enzyme, res subunit - - - - - - - - - - - - - k59_264713_1 985054.JQEZ01000004_gene723 9.75e-31 113.0 COG2832@1|root,COG2832@2|Bacteria,1N7BI@1224|Proteobacteria,2UFAC@28211|Alphaproteobacteria,4NCDQ@97050|Ruegeria 28211|Alphaproteobacteria S Protein of unknown function (DUF454) ybaN - - ko:K09790 - - - - ko00000 - - - DUF454 k59_264713_2 1122603.ATVI01000005_gene3497 4.79e-11 62.8 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1T49A@1236|Gammaproteobacteria 1236|Gammaproteobacteria S cAMP biosynthetic process - - - - - - - - - - - - - k59_1152433_1 1265310.CCBD010000031_gene1772 4.67e-16 75.5 COG1846@1|root,COG1846@2|Bacteria,2I3KG@201174|Actinobacteria,238P5@1762|Mycobacteriaceae 201174|Actinobacteria K nitroreductase - GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0030312,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070967,GO:0071944,GO:0097159,GO:0097367,GO:1901363 - - - - - - - - - - F420H2_quin_red,MarR k59_1152433_2 502025.Hoch_2048 7.11e-60 202.0 COG0121@1|root,COG1305@1|root,COG0121@2|Bacteria,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,42PJK@68525|delta/epsilon subdivisions,2WMCS@28221|Deltaproteobacteria,2YU92@29|Myxococcales 28221|Deltaproteobacteria E Bacterial transglutaminase-like N-terminal region - - - - - - - - - - - - Bact_transglu_N,GATase_4,Transglut_core k59_1048204_1 1299327.I546_1532 3.23e-09 59.7 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity devC - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1048204_2 273121.WS0924 1.85e-05 47.8 COG1131@1|root,COG1131@2|Bacteria,1MXHE@1224|Proteobacteria,42PFF@68525|delta/epsilon subdivisions,2YMKC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria V abc transporter atp-binding protein nosF - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_577973_1 1313172.YM304_26210 2.51e-49 177.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria,4CMW5@84992|Acidimicrobiia 201174|Actinobacteria CJ CoA binding domain acdA1 - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_577973_2 251229.Chro_0825 1.33e-119 360.0 COG1115@1|root,COG1115@2|Bacteria,1G1I5@1117|Cyanobacteria,3VJ8N@52604|Pleurocapsales 1117|Cyanobacteria E PFAM Sodium alanine symporter family - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_56499_1 502025.Hoch_5279 1.13e-41 151.0 COG0543@1|root,COG0543@2|Bacteria,1QTSK@1224|Proteobacteria,43CMU@68525|delta/epsilon subdivisions,2X7V0@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Oxidoreductase FAD-binding domain - - - - - - - - - - - - FAD_binding_6,NAD_binding_1 k59_683309_1 153721.MYP_2422 6.12e-136 404.0 COG0438@1|root,COG0438@2|Bacteria,4NDUY@976|Bacteroidetes 976|Bacteroidetes M Glycosyl transferases group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 k59_1152443_1 1089439.KB902240_gene720 3.84e-31 123.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,4601P@72273|Thiotrichales 72273|Thiotrichales EGP major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_212403_1 1144305.PMI02_01116 4.93e-95 304.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria,2K03D@204457|Sphingomonadales 204457|Sphingomonadales S PFAM amidohydrolase - - - - - - - - - - - - Amidohydro_3 k59_1413563_1 760117.JN27_20210 1.26e-50 171.0 COG1295@1|root,COG1295@2|Bacteria,1NH82@1224|Proteobacteria,2VJW7@28216|Betaproteobacteria,472BA@75682|Oxalobacteraceae 28216|Betaproteobacteria S Virulence factor BrkB - - - - - - - - - - - - Virul_fac_BrkB k59_1152447_1 439235.Dalk_4633 1.36e-40 150.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WJKC@28221|Deltaproteobacteria,2MJ79@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_943408_1 1504672.669785679 7.66e-94 289.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2VKD6@28216|Betaproteobacteria,4AF3N@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM transposase, mutator type - - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_1100563_2 444860.E3SJ54_9CAUD 6.04e-25 102.0 4QDUC@10239|Viruses,4QV7K@35237|dsDNA viruses no RNA stage,4QR22@28883|Caudovirales,4QJ6D@10662|Myoviridae 10662|Myoviridae S transferase activity - - - - - - - - - - - - - k59_159096_1 1535422.ND16A_0875 2.32e-19 89.7 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1RMXU@1236|Gammaproteobacteria,2Q61F@267889|Colwelliaceae 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - - SSF k59_159096_2 266779.Meso_1502 3.9e-32 127.0 COG2230@1|root,COG2230@2|Bacteria,1QY55@1224|Proteobacteria,2TXG3@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Putative methyltransferase - - - - - - - - - - - - Methyltransf_31 k59_1413571_1 1121935.AQXX01000114_gene3255 5.42e-86 275.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1XH5U@135619|Oceanospirillales 135619|Oceanospirillales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_107577_1 153948.NAL212_2787 1.37e-18 80.5 2AHT0@1|root,3185H@2|Bacteria,1PZUW@1224|Proteobacteria,2WC28@28216|Betaproteobacteria,373KC@32003|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_577996_1 1121949.AQXT01000002_gene2815 8.58e-28 116.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2TVI8@28211|Alphaproteobacteria,43XT1@69657|Hyphomonadaceae 28211|Alphaproteobacteria G COG2211 Na melibiose symporter and related transporters - - - - - - - - - - - - MFS_2 k59_1152458_1 2340.JV46_21300 7.48e-34 125.0 2CDCV@1|root,308Y1@2|Bacteria,1N74F@1224|Proteobacteria,1SFME@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1152458_2 1117647.M5M_10547 7.33e-28 111.0 COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,1T05M@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Magnesium transport protein CorA corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_525768_1 666685.R2APBS1_1716 1.2e-59 207.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1X3SD@135614|Xanthomonadales 135614|Xanthomonadales Q multicopper - - - - - - - - - - - - Cu-oxidase_2,Cu-oxidase_3,DUF4396 k59_525768_2 1123024.AUII01000049_gene3642 3.86e-05 49.3 COG0346@1|root,COG0346@2|Bacteria,2HKRN@201174|Actinobacteria 201174|Actinobacteria E glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_1257896_1 756272.Plabr_4327 2.32e-54 186.0 COG0160@1|root,COG0160@2|Bacteria,2IX55@203682|Planctomycetes 203682|Planctomycetes H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1205745_1 1000565.METUNv1_03397 6.34e-09 58.2 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2VSP6@28216|Betaproteobacteria,2KWKV@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the ompA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_1205745_2 400682.PAC_15706429 8.46e-24 96.7 COG0823@1|root,2QPTW@2759|Eukaryota,3968E@33154|Opisthokonta,3BR8I@33208|Metazoa 33208|Metazoa U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40,TolB_N k59_317170_1 1183438.GKIL_3738 1.01e-66 219.0 COG1232@1|root,COG1232@2|Bacteria,1G05M@1117|Cyanobacteria 1117|Cyanobacteria H Protoporphyrinogen oxidase - - - - - - - - - - - - Amino_oxidase k59_473246_1 1283300.ATXB01000001_gene693 5.84e-127 379.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1XDMC@135618|Methylococcales 135618|Methylococcales J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_1309093_1 1485544.JQKP01000002_gene1434 1.16e-119 350.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2VHBP@28216|Betaproteobacteria,44UYZ@713636|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_525773_1 309801.trd_1931 5.75e-155 474.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G86T@200795|Chloroflexi,27XQK@189775|Thermomicrobia 189775|Thermomicrobia G Alpha-amylase domain - - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - APH,Alpha-amylase,Malt_amylase_C k59_1048245_1 95619.PM1_0206645 1.65e-74 239.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the MurCDEF family murC GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iECP_1309.ECP_0093 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1466333_1 671143.DAMO_2383 9.96e-210 590.0 COG0719@1|root,COG0719@2|Bacteria,2NNKT@2323|unclassified Bacteria 2|Bacteria O FeS assembly protein SufB sufB GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840 - ko:K07033,ko:K09014 - - - - ko00000 - - iAPECO1_1312.APECO1_760,iECH74115_1262.ECH74115_2397,iECSF_1327.ECSF_1543,iECSP_1301.ECSP_2250,iUTI89_1310.UTI89_C1875,ic_1306.c2078 UPF0051 k59_264762_1 994479.GL877878_gene2640 1.55e-27 112.0 COG2141@1|root,COG2141@2|Bacteria,2GMMJ@201174|Actinobacteria,4DZWI@85010|Pseudonocardiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_683367_1 172088.AUGA01000001_gene6253 3.13e-107 343.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,3JSNT@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Glutamate synthase gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1156493_1 861299.J421_0897 1.76e-114 342.0 COG0031@1|root,COG0031@2|Bacteria,1ZTA6@142182|Gemmatimonadetes 142182|Gemmatimonadetes EK Domain in cystathionine beta-synthase and other proteins. - - 4.2.1.22 ko:K01697 ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 M00035,M00338 R00891,R01290,R04942 RC00056,RC00069,RC00256,RC00489,RC01246 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP k59_738566_1 28583.AMAG_13152T0 3.48e-09 61.6 KOG0591@1|root,KOG0591@2759|Eukaryota,38DMS@33154|Opisthokonta,3PCZE@4751|Fungi 33154|Opisthokonta D Allomyces macrogynus ATCC 38327 NEK NEK6 protein kinase NEK6 GO:0000003,GO:0000166,GO:0000226,GO:0000278,GO:0000287,GO:0000922,GO:0001221,GO:0001222,GO:0001932,GO:0001934,GO:0003006,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005815,GO:0005819,GO:0005829,GO:0005856,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0006997,GO:0006998,GO:0007010,GO:0007017,GO:0007049,GO:0007051,GO:0007059,GO:0007077,GO:0007088,GO:0007154,GO:0007165,GO:0007275,GO:0007346,GO:0007548,GO:0008092,GO:0008134,GO:0008144,GO:0008150,GO:0008152,GO:0008406,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010256,GO:0010556,GO:0010557,GO:0010562,GO:0010564,GO:0010604,GO:0010638,GO:0010941,GO:0010965,GO:0015630,GO:0016020,GO:0016043,GO:0016301,GO:0016310,GO:0016324,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018105,GO:0018193,GO:0018209,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0019894,GO:0019899,GO:0019900,GO:0019901,GO:0022402,GO:0022411,GO:0022414,GO:0022607,GO:0023014,GO:0023052,GO:0030071,GO:0030397,GO:0030554,GO:0031098,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031399,GO:0031401,GO:0031625,GO:0031974,GO:0031981,GO:0032147,GO:0032204,GO:0032206,GO:0032210,GO:0032212,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033043,GO:0033044,GO:0033045,GO:0033047,GO:0033554,GO:0033613,GO:0033674,GO:0035264,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042303,GO:0042325,GO:0042327,GO:0042981,GO:0043067,GO:0043085,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043549,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044451,GO:0044459,GO:0044464,GO:0045137,GO:0045177,GO:0045859,GO:0045860,GO:0045935,GO:0045937,GO:0046777,GO:0046872,GO:0048513,GO:0048518,GO:0048522,GO:0048583,GO:0048589,GO:0048608,GO:0048731,GO:0048856,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051081,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051174,GO:0051225,GO:0051246,GO:0051247,GO:0051338,GO:0051347,GO:0051716,GO:0051726,GO:0051783,GO:0051972,GO:0051973,GO:0051983,GO:0060255,GO:0061024,GO:0061458,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070925,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0080134,GO:0080135,GO:0090342,GO:0097159,GO:0097367,GO:0098590,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901987,GO:1901990,GO:1902099,GO:1903047,GO:1904353,GO:1904355,GO:1904356,GO:1904358,GO:1905818,GO:2000112,GO:2000278,GO:2000573,GO:2000772,GO:2001252 2.7.11.1 ko:K20875,ko:K20876 ko04621,map04621 - - - ko00000,ko00001,ko01000,ko01001,ko03036 1.I.1.1.3 - - Pkinase k59_738566_2 366394.Smed_5507 3.05e-05 47.0 COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,2TQRI@28211|Alphaproteobacteria,4BA4I@82115|Rhizobiaceae 28211|Alphaproteobacteria H molybdopterin moeA - 2.10.1.1 ko:K03750,ko:K07219 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N,PBP_like k59_162100_1 7176.CPIJ040086-PA 5.16e-15 80.1 COG1290@1|root,KOG4663@2759|Eukaryota,38FBZ@33154|Opisthokonta,3BCGI@33208|Metazoa,3CZ4H@33213|Bilateria,41ZKH@6656|Arthropoda,3SJNY@50557|Insecta,451FJ@7147|Diptera,45GXE@7148|Nematocera 33208|Metazoa C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis CYTB GO:0000003,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005750,GO:0006091,GO:0006119,GO:0006122,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0006979,GO:0007275,GO:0007276,GO:0007283,GO:0007584,GO:0008121,GO:0008150,GO:0008152,GO:0009055,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009266,GO:0009408,GO:0009605,GO:0009628,GO:0009636,GO:0009651,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010243,GO:0014070,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016679,GO:0016681,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0019953,GO:0020037,GO:0022414,GO:0022900,GO:0022904,GO:0031090,GO:0031099,GO:0031100,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031667,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0032504,GO:0032592,GO:0032991,GO:0033273,GO:0033590,GO:0033762,GO:0034220,GO:0034641,GO:0036293,GO:0036296,GO:0042221,GO:0042493,GO:0042538,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043434,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044703,GO:0044877,GO:0045275,GO:0045333,GO:0045471,GO:0046034,GO:0046483,GO:0046677,GO:0046686,GO:0046688,GO:0046689,GO:0046906,GO:0048037,GO:0048038,GO:0048039,GO:0048232,GO:0048513,GO:0048609,GO:0048731,GO:0048856,GO:0050896,GO:0051179,GO:0051234,GO:0051592,GO:0051704,GO:0055085,GO:0055086,GO:0055093,GO:0055114,GO:0070069,GO:0070469,GO:0070482,GO:0071704,GO:0072521,GO:0097159,GO:0097305,GO:0098573,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1901652,GO:1901698,GO:1901700,GO:1902494,GO:1902600,GO:1990204 - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_792930_1 357804.Ping_2963 4.32e-26 109.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,2QHD0@267894|Psychromonadaceae 1236|Gammaproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0019897,GO:0019898,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 iE2348C_1286.E2348C_0187,iEcolC_1368.EcolC_3478 LpxB k59_947037_1 1123400.KB904816_gene1593 9.24e-112 345.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,45ZYT@72273|Thiotrichales 72273|Thiotrichales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_738573_1 472759.Nhal_0598 5.52e-95 290.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WVVT@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_373084_2 1167006.UWK_01423 4.34e-29 110.0 COG3090@1|root,COG3090@2|Bacteria,1MZNX@1224|Proteobacteria,42TZJ@68525|delta/epsilon subdivisions,2WQB8@28221|Deltaproteobacteria,2MKJH@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Tripartite ATP-independent periplasmic transporter, DctQ component - - - - - - - - - - - - DctQ k59_1519845_1 1313421.JHBV01000002_gene522 2.8e-40 142.0 COG0020@1|root,COG0020@2|Bacteria,4NF2B@976|Bacteroidetes,1IPRJ@117747|Sphingobacteriia 976|Bacteroidetes I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_1471869_1 653733.Selin_0876 2.73e-111 328.0 COG1086@1|root,COG1086@2|Bacteria 2|Bacteria GM Polysaccharide biosynthesis protein pseB - 4.2.1.115 ko:K15894 ko00520,map00520 - R09697 RC02609 ko00000,ko00001,ko01000 - - - Polysacc_synt_2 k59_1211704_1 1254432.SCE1572_20990 1.45e-44 157.0 COG0604@1|root,COG0604@2|Bacteria,1R2DZ@1224|Proteobacteria,43DM8@68525|delta/epsilon subdivisions,2X65T@28221|Deltaproteobacteria,2Z39E@29|Myxococcales 28221|Deltaproteobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_62505_1 626887.J057_09971 1.91e-122 363.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,4653S@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the peptidase M20A family. ArgE subfamily argE GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0008777,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019752,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - iECUMN_1333.ECUMN_4488 M20_dimer,Peptidase_M20,Peptidase_M28 k59_582449_1 290400.Jann_3111 9.35e-26 107.0 COG0803@1|root,COG0803@2|Bacteria,1RAQU@1224|Proteobacteria,2UQPU@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Zinc-uptake complex component A periplasmic - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_269374_1 998674.ATTE01000001_gene2455 9.15e-79 246.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_269374_2 413404.Rmag_0035 3.03e-66 216.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1J4DV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - iJN746.PP_0104 COX1 k59_216982_1 1232410.KI421418_gene2158 4.66e-30 123.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria,43UC5@69541|Desulfuromonadales 28221|Deltaproteobacteria NU Bacterial type II/III secretion system short domain gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_1052940_1 768671.ThimaDRAFT_0077 6.79e-82 258.0 COG0526@1|root,COG0526@2|Bacteria,1MWDE@1224|Proteobacteria,1S0NV@1236|Gammaproteobacteria,1WXDD@135613|Chromatiales 135613|Chromatiales CO COG0526, thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - Glutaredoxin k59_1157078_1 443144.GM21_1226 5.37e-32 125.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,42NBS@68525|delta/epsilon subdivisions,2WIP2@28221|Deltaproteobacteria,43T8J@69541|Desulfuromonadales 28221|Deltaproteobacteria H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1624 RibD_C,dCMP_cyt_deam_1 k59_373754_1 1449347.JQLN01000004_gene6453 0.000363 48.9 COG2132@1|root,COG2132@2|Bacteria,2IDP7@201174|Actinobacteria 201174|Actinobacteria Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase_3 k59_1313705_1 402626.Rpic_4115 3.47e-77 235.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VR39@28216|Betaproteobacteria,1K5JG@119060|Burkholderiaceae 28216|Betaproteobacteria S Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_1105271_1 717774.Marme_0765 2.88e-25 109.0 COG0477@1|root,COG2814@2|Bacteria,1MXKN@1224|Proteobacteria,1S1A0@1236|Gammaproteobacteria,1XKDK@135619|Oceanospirillales 135619|Oceanospirillales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1052945_1 349124.Hhal_1682 3.08e-111 335.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1WXCW@135613|Chromatiales 135613|Chromatiales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_1157082_2 163908.KB235896_gene4692 1.28e-40 142.0 COG0748@1|root,COG0748@2|Bacteria,1G7II@1117|Cyanobacteria,1HN5M@1161|Nostocales 1117|Cyanobacteria P heme iron utilization protein - - - ko:K07226 - - - - ko00000 - - - Putative_PNPOx k59_426012_1 272624.lpg1911 7.76e-51 175.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1JDM9@118969|Legionellales 118969|Legionellales J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_530228_1 596151.DesfrDRAFT_3046 6.2e-13 73.6 COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,42R2X@68525|delta/epsilon subdivisions,2WMU1@28221|Deltaproteobacteria,2MAZ8@213115|Desulfovibrionales 28221|Deltaproteobacteria NU PFAM Type II secretion system F - - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF k59_530228_2 667632.KB890165_gene2425 0.00027 44.7 COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2VJ80@28216|Betaproteobacteria,1K2UP@119060|Burkholderiaceae 28216|Betaproteobacteria U Type II secretion system tadB1 - - ko:K12510 - - - - ko00000,ko02044 - - - T2SSF k59_216992_1 1459636.NTE_02907 2.55e-105 313.0 COG0010@1|root,arCOG01700@2157|Archaea,41T03@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the arginase family - - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_62531_1 645991.Sgly_0883 4.42e-17 82.4 COG0745@1|root,COG0745@2|Bacteria,1TSWT@1239|Firmicutes,248B6@186801|Clostridia,261AI@186807|Peptococcaceae 186801|Clostridia K PFAM Response regulator receiver domain - - - - - - - - - - - - Response_reg,Trans_reg_C k59_843902_1 999141.GME_18872 3.7e-137 406.0 COG3960@1|root,COG3960@2|Bacteria,1MV88@1224|Proteobacteria,1RW45@1236|Gammaproteobacteria,1XNQX@135619|Oceanospirillales 135619|Oceanospirillales S Belongs to the TPP enzyme family - - 4.1.1.47 ko:K01608 ko00630,ko01100,map00630,map01100 - R00013 RC00899 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_793811_1 316067.Geob_0929 2.37e-51 172.0 COG2823@1|root,COG2823@2|Bacteria,1RFX5@1224|Proteobacteria,42UUG@68525|delta/epsilon subdivisions,2WQ1N@28221|Deltaproteobacteria,43U92@69541|Desulfuromonadales 28221|Deltaproteobacteria S BON domain - - - - - - - - - - - - BON k59_530232_1 247634.GPB2148_429 2.54e-83 259.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1J4ST@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0306 Phosphate sulphate permeases pitA GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_947707_1 945713.IALB_2743 2.24e-48 159.0 COG2110@1|root,COG2110@2|Bacteria 2|Bacteria P phosphatase homologous to the C-terminal domain of histone macroH2A1 ymdB - - - - - - - - - - - Macro k59_947707_2 686340.Metal_0305 3.87e-19 82.4 COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,1XFC6@135618|Methylococcales 135618|Methylococcales S PFAM Stringent starvation protein B sspB - - ko:K03600 - - - - ko00000,ko03021 - - - SspB k59_269389_1 45351.EDO40599 1.2e-05 55.5 KOG3644@1|root,KOG3644@2759|Eukaryota,38BM7@33154|Opisthokonta,3BA9E@33208|Metazoa 33208|Metazoa T extracellularly glycine-gated chloride channel activity GluCl GO:0001508,GO:0003008,GO:0003674,GO:0005215,GO:0005216,GO:0005230,GO:0005231,GO:0005234,GO:0005253,GO:0005254,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006821,GO:0007154,GO:0007165,GO:0007166,GO:0007267,GO:0007268,GO:0007600,GO:0007606,GO:0007610,GO:0007626,GO:0008068,GO:0008144,GO:0008150,GO:0008509,GO:0009987,GO:0015075,GO:0015103,GO:0015108,GO:0015267,GO:0015276,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0016043,GO:0016595,GO:0016597,GO:0022607,GO:0022803,GO:0022834,GO:0022836,GO:0022838,GO:0022839,GO:0022857,GO:0023052,GO:0031224,GO:0031226,GO:0031406,GO:0031987,GO:0032501,GO:0034220,GO:0036094,GO:0040011,GO:0042221,GO:0042391,GO:0042493,GO:0042802,GO:0043051,GO:0043167,GO:0043168,GO:0043177,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050795,GO:0050877,GO:0050890,GO:0050893,GO:0050896,GO:0051179,GO:0051234,GO:0051259,GO:0051716,GO:0055085,GO:0060078,GO:0060079,GO:0060259,GO:0065003,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:0098916,GO:0099095,GO:0099536,GO:0099537,GO:0099565,GO:1902476,GO:1903998,GO:1905114 - ko:K05193,ko:K05194,ko:K05195,ko:K05273 ko04080,map04080 - - - ko00000,ko00001,ko04040,ko04131 1.A.9.3,1.A.9.4 - - Neur_chan_LBD,Neur_chan_memb k59_793820_1 1121382.JQKG01000001_gene2422 6.51e-15 70.9 COG0824@1|root,COG0824@2|Bacteria,1WKEF@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S PFAM thioesterase superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_478155_1 1279019.ARQK01000043_gene2163 2.02e-30 115.0 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,1WYRV@135613|Chromatiales 135613|Chromatiales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_1211747_1 445686.E3SL60_9CAUD 2.87e-217 627.0 4QAZ6@10239|Viruses,4QUU8@35237|dsDNA viruses no RNA stage,4QPHV@28883|Caudovirales,4QI4H@10662|Myoviridae 10662|Myoviridae S Phage tail sheath protein - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098027 - - - - - - - - - - - k59_111875_1 1046714.AMRX01000003_gene235 3.22e-19 97.4 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,464CY@72275|Alteromonadaceae 1236|Gammaproteobacteria S membrane yhdP GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - - - - - - - - - - AsmA_2,DUF3971 k59_637115_2 1463864.JOGO01000001_gene1722 1.1e-49 178.0 COG1168@1|root,COG1168@2|Bacteria,2GJFQ@201174|Actinobacteria 201174|Actinobacteria E Aminotransferase, class I aecD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 4.4.1.8 ko:K00842,ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_62564_1 1038859.AXAU01000026_gene2328 2.05e-102 306.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,3JRF7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EP Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_843932_1 1095769.CAHF01000006_gene1913 2.78e-107 319.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VJI3@28216|Betaproteobacteria,475IE@75682|Oxalobacteraceae 28216|Betaproteobacteria E Pyridoxal-phosphate dependent enzyme cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_793849_1 2340.JV46_23390 6.7e-08 53.9 COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria,1S4VY@1236|Gammaproteobacteria,1JAMV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D sister chromatid segregation - - - - - - - - - - - - - k59_947733_1 439375.Oant_1366 1.32e-36 136.0 28HK0@1|root,2Z7V0@2|Bacteria,1MXSJ@1224|Proteobacteria,2TSDQ@28211|Alphaproteobacteria,1J28P@118882|Brucellaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF4105) - - - - - - - - - - - - DUF4105 k59_1263893_1 1396141.BATP01000044_gene1492 1.11e-41 153.0 COG0644@1|root,COG0644@2|Bacteria,46TIC@74201|Verrucomicrobia 74201|Verrucomicrobia C Tryptophan halogenase - - - - - - - - - - - - Trp_halogenase k59_1211767_1 246196.MSMEI_0647 1.83e-89 280.0 COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,234PD@1762|Mycobacteriaceae 201174|Actinobacteria Q NAD(P)-binding Rossmann-like domain - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_1052981_1 65393.PCC7424_0688 1.71e-150 444.0 COG0028@1|root,COG0028@2|Bacteria,1G0KQ@1117|Cyanobacteria,3KG17@43988|Cyanothece 1117|Cyanobacteria EH Belongs to the TPP enzyme family ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1627463_1 1144307.PMI04_04529 1.23e-07 53.1 COG0625@1|root,COG0625@2|Bacteria,1N8XH@1224|Proteobacteria,2TTHQ@28211|Alphaproteobacteria,2K1AK@204457|Sphingomonadales 204457|Sphingomonadales O Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C_3 k59_1627463_2 247633.GP2143_05250 4.56e-155 441.0 COG1024@1|root,COG1024@2|Bacteria,1PK10@1224|Proteobacteria,1RSCH@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG1024 Enoyl-CoA hydratase carnithine racemase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1627463_3 1206101.AZXC01000010_gene47 3.15e-36 133.0 COG1309@1|root,COG1309@2|Bacteria,2ICRJ@201174|Actinobacteria 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1627463_4 1283299.AUKG01000001_gene3024 5.86e-11 63.2 COG3226@1|root,COG3226@2|Bacteria,2HPR7@201174|Actinobacteria,4CR4E@84995|Rubrobacteria 84995|Rubrobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_689007_1 246197.MXAN_0988 9.22e-108 340.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2YUB0@29|Myxococcales 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_1627465_1 314278.NB231_15993 5.12e-43 150.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,1WXAH@135613|Chromatiales 135613|Chromatiales J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_689008_1 861299.J421_5987 8.09e-78 256.0 COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria 2|Bacteria L DNA ligase (ATP) activity - - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N k59_1471958_1 1405498.SSIM_11195 1.31e-14 72.8 COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,4HHI5@91061|Bacilli,4GX17@90964|Staphylococcaceae 91061|Bacilli L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_1471958_2 1191523.MROS_0744 1.02e-10 62.4 COG0817@1|root,COG0817@2|Bacteria 2|Bacteria L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_1263907_1 331869.BAL199_02679 1.73e-102 310.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,4BP6C@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_999819_1 756272.Plabr_3778 2e-30 125.0 COG3119@1|root,COG3119@2|Bacteria,2IYH5@203682|Planctomycetes 203682|Planctomycetes P COG3119 Arylsulfatase A - - - - - - - - - - - - Sulfatase k59_478193_1 1108045.GORHZ_040_00230 1.26e-19 89.7 COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4GA6P@85026|Gordoniaceae 201174|Actinobacteria C Alcohol dehydrogenase GroES-like domain - - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_478193_2 1101188.KI912155_gene1515 2.42e-20 99.4 COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria 201174|Actinobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1211786_1 312309.VF_2067 6.1e-86 264.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,1XSUN@135623|Vibrionales 135623|Vibrionales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoS - - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1211786_2 765914.ThisiDRAFT_1457 1.64e-34 126.0 COG4942@1|root,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,1RR11@1236|Gammaproteobacteria,1WW55@135613|Chromatiales 135613|Chromatiales DM peptidase - - - ko:K06194 - - - - ko00000 1.A.34.1.2 - - LysM,Peptidase_M23 k59_1157136_1 765914.ThisiDRAFT_1982 5.94e-95 287.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1WXNW@135613|Chromatiales 135613|Chromatiales E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_217048_1 519989.ECTPHS_03884 1.13e-77 244.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1WX7A@135613|Chromatiales 135613|Chromatiales H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_999825_1 1230476.C207_02667 4.86e-24 100.0 COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,2TSIV@28211|Alphaproteobacteria,3JVD2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Fructose-bisphosphate aldolase class-I fbaB - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic k59_1366287_1 153948.NAL212_1385 4.27e-09 62.8 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VHNB@28216|Betaproteobacteria,371VU@32003|Nitrosomonadales 28216|Betaproteobacteria L Belongs to the helicase family. UvrD subfamily addA - 3.1.11.5 ko:K03582 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_739237_1 985255.APHJ01000025_gene1062 3.11e-18 90.9 COG0457@1|root,COG0642@1|root,COG0784@1|root,COG0457@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,4NDXU@976|Bacteroidetes,1HXPB@117743|Flavobacteriia,2P5JI@244698|Gillisia 976|Bacteroidetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg,TPR_12,TPR_8 k59_162781_1 305700.B447_01426 5.41e-09 57.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,2KV7H@206389|Rhodocyclales 206389|Rhodocyclales I Desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - DDE_Tnp_ISL3,FA_desaturase k59_1263926_1 1045009.AFXQ01000003_gene2754 1.24e-44 163.0 COG0477@1|root,COG0477@2|Bacteria,2GIYR@201174|Actinobacteria,1WB3X@1268|Micrococcaceae 201174|Actinobacteria EGP Sugar (and other) transporter proP - - ko:K03762 - - - - ko00000,ko02000 2.A.1.6.4 - - MFS_1,Sugar_tr k59_999828_1 935848.JAEN01000008_gene616 4.23e-50 185.0 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TUMK@28211|Alphaproteobacteria,2PWEW@265|Paracoccus 28211|Alphaproteobacteria E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_1053012_2 1231391.AMZF01000030_gene321 2.57e-13 74.3 COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,2VMZQ@28216|Betaproteobacteria,3T34Z@506|Alcaligenaceae 28216|Betaproteobacteria T factor regulatory protein rseB - - ko:K03598 - - - - ko00000,ko03021 - - - MucB_RseB,MucB_RseB_C k59_947777_1 911045.PSE_0438 7.38e-90 273.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR3F@28211|Alphaproteobacteria 28211|Alphaproteobacteria EP COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1366307_2 996637.SGM_0018 2.36e-13 72.8 COG0642@1|root,COG2205@2|Bacteria,2GM17@201174|Actinobacteria 201174|Actinobacteria T Histidine kinase - - 2.7.13.3 ko:K07653 ko02020,map02020 M00460 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_1105353_2 472759.Nhal_1310 4.7e-140 409.0 COG1562@1|root,COG1562@2|Bacteria,1R4ZD@1224|Proteobacteria,1RS93@1236|Gammaproteobacteria,1X0KC@135613|Chromatiales 135613|Chromatiales I Squalene phytoene synthase - - 2.5.1.21 ko:K00801 ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130 - R00702,R02872,R06223 RC00362,RC00796,RC02839 ko00000,ko00001,ko01000,ko01006 - - - SQS_PSY k59_999851_1 266779.Meso_2677 2.14e-55 193.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2TR5K@28211|Alphaproteobacteria,43JF8@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_1211823_1 247490.KSU1_C1324 7.98e-34 138.0 COG1957@1|root,COG3055@1|root,COG3204@1|root,COG4932@1|root,COG1957@2|Bacteria,COG3055@2|Bacteria,COG3204@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - - ko:K02674,ko:K07004 - - - - ko00000,ko02035,ko02044 - - - DUF547,Laminin_G_3,Malectin k59_221846_2 929556.Solca_1659 8.61e-54 175.0 COG0702@1|root,COG0702@2|Bacteria,4NMI5@976|Bacteroidetes,1ISKB@117747|Sphingobacteriia 976|Bacteroidetes GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - NAD_binding_10 k59_484342_1 330214.NIDE0261 8.03e-22 89.7 COG0740@1|root,COG0740@2|Bacteria,3J0A3@40117|Nitrospirae 40117|Nitrospirae O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_484342_2 330214.NIDE0262 1.89e-29 118.0 COG0544@1|root,COG0544@2|Bacteria,3J12E@40117|Nitrospirae 40117|Nitrospirae O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - Trigger_C,Trigger_N k59_643269_1 1174528.JH992893_gene5975 1.78e-94 303.0 COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1G15G@1117|Cyanobacteria,1JHXK@1189|Stigonemataceae 1117|Cyanobacteria G Transaldolase/Fructose-6-phosphate aldolase - - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k59_800208_1 452637.Oter_0491 1.25e-22 105.0 COG4888@1|root,COG4888@2|Bacteria,46UDG@74201|Verrucomicrobia 74201|Verrucomicrobia O PFAM ASPIC UnbV domain protein - - - - - - - - - - - - FG-GAP,UnbV_ASPIC,VCBS k59_743857_1 1123073.KB899241_gene2109 2.43e-08 60.8 COG1879@1|root,COG2374@1|root,COG1879@2|Bacteria,COG2374@2|Bacteria,1MX52@1224|Proteobacteria,1RRGN@1236|Gammaproteobacteria,1X3H2@135614|Xanthomonadales 135614|Xanthomonadales Q Lamin Tail Domain - - - - - - - - - - - - Calx-beta,LTD k59_378910_2 231434.JQJH01000001_gene1841 1.7e-05 50.8 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria,3N9U4@45404|Beijerinckiaceae 28211|Alphaproteobacteria O Tetratricopeptide repeat trxA2 - - ko:K03671,ko:K05838 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_1477957_2 754477.Q7C_1857 8.52e-05 47.4 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria,460PI@72273|Thiotrichales 72273|Thiotrichales H HemY protein N-terminus - - - ko:K02498 - - - - ko00000 - - - HemY_N k59_643287_2 1337093.MBE-LCI_2049 3.23e-62 207.0 COG2223@1|root,COG2223@2|Bacteria,1MWC7@1224|Proteobacteria,2TWNV@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1632474_1 648996.Theam_1691 2.27e-06 52.4 COG0539@1|root,COG0539@2|Bacteria,2G4B4@200783|Aquificae 200783|Aquificae J RNA binding S1 domain protein rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_1109984_2 261292.Nit79A3_2908 7.47e-48 159.0 COG1278@1|root,COG1544@1|root,COG1278@2|Bacteria,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,2VR5Q@28216|Betaproteobacteria,372T2@32003|Nitrosomonadales 28216|Betaproteobacteria J Sigma 54 modulation protein / S30EA ribosomal protein - - - - - - - - - - - - CSD,Ribosomal_S30AE k59_116739_1 159087.Daro_4041 1.32e-20 95.5 COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,2VKGG@28216|Betaproteobacteria,2KVG7@206389|Rhodocyclales 206389|Rhodocyclales S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_643309_1 448385.sce2973 8.11e-41 150.0 COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria,43A4M@68525|delta/epsilon subdivisions,2WYKE@28221|Deltaproteobacteria,2Z0NN@29|Myxococcales 28221|Deltaproteobacteria E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_1477984_2 525909.Afer_1034 3.14e-44 153.0 COG1024@1|root,COG1024@2|Bacteria,2GJ0N@201174|Actinobacteria,4CNYM@84992|Acidimicrobiia 84992|Acidimicrobiia I Enoyl-CoA hydratase/isomerase - - 4.2.1.18 ko:K13766 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1004900_1 1283078.M1HM90_9CAUD 2.48e-14 81.6 4QBHY@10239|Viruses,4QVX2@35237|dsDNA viruses no RNA stage,4QQWC@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1317670_1 444861.E3SPB3_9CAUD 2.41e-14 69.3 4QD1C@10239|Viruses,4QXXJ@35237|dsDNA viruses no RNA stage,4QQTB@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1317670_2 10726.TFLIV_BPT5 1.58e-23 96.7 4QCEE@10239|Viruses,4R0AI@35237|dsDNA viruses no RNA stage,4QUJC@28883|Caudovirales 28883|Caudovirales - - - GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_484408_1 886882.PPSC2_c0980 7.62e-06 53.1 COG1309@1|root,COG1309@2|Bacteria,1V956@1239|Firmicutes,4HIJQ@91061|Bacilli,26TKY@186822|Paenibacillaceae 91061|Bacilli K Transcriptional regulator tetR3 - - ko:K18476 - M00668 - - ko00000,ko00002,ko03000 - - - TetR_C,TetR_N k59_68661_1 1380355.JNIJ01000001_gene3989 7.29e-56 180.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,3JU16@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E ATPases associated with a variety of cellular activities - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_693740_1 998674.ATTE01000001_gene4344 2.22e-74 233.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,46040@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_693740_2 1304883.KI912532_gene1615 6.02e-10 58.9 COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,2VI8F@28216|Betaproteobacteria,2KW3F@206389|Rhodocyclales 206389|Rhodocyclales M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_743904_1 243231.GSU2187 6.07e-31 126.0 COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,42MX2@68525|delta/epsilon subdivisions,2WIUV@28221|Deltaproteobacteria 28221|Deltaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_116766_1 1500306.JQLA01000010_gene923 3.96e-24 103.0 COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,2U3ND@28211|Alphaproteobacteria,4BB6E@82115|Rhizobiaceae 28211|Alphaproteobacteria S phenazine biosynthesis protein phzF - 5.3.3.17 ko:K06998 ko00405,ko01130,ko02024,map00405,map01130,map02024 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - PhzC-PhzF k59_952570_2 265072.Mfla_0592 1.03e-30 112.0 COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,2VQ2M@28216|Betaproteobacteria,2KMNH@206350|Nitrosomonadales 206350|Nitrosomonadales J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase k59_901047_2 1502851.FG93_00529 4.36e-36 131.0 COG0560@1|root,COG0560@2|Bacteria,1MW38@1224|Proteobacteria,2TVAB@28211|Alphaproteobacteria,3JUMP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD k59_326900_1 247633.GP2143_10897 2.25e-10 61.2 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1J574@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Glycos_transf_4,MraY_sig1 k59_326900_2 395493.BegalDRAFT_0742 7.52e-23 99.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,4606K@72273|Thiotrichales 72273|Thiotrichales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_326902_1 497964.CfE428DRAFT_0230 2.75e-52 187.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,46TGZ@74201|Verrucomicrobia 74201|Verrucomicrobia T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_116778_1 588596.U9UPA2 2.93e-14 69.3 COG3526@1|root,2S6UH@2759|Eukaryota,3A6V6@33154|Opisthokonta,3P55U@4751|Fungi 4751|Fungi O selenoprotein - - - ko:K07401 - - - - ko00000 - - - Rdx k59_167519_1 1267535.KB906767_gene907 6.32e-19 91.3 COG0308@1|root,COG0457@1|root,COG0308@2|Bacteria,COG0457@2|Bacteria 2|Bacteria S peptidyl-tyrosine sulfation - - - - - - - - - - - - Peptidase_M1,TPR_16,TPR_19,TPR_8 k59_848594_1 1156937.MFUM_960010 5.99e-17 82.0 COG2107@1|root,COG2107@2|Bacteria,46U2Z@74201|Verrucomicrobia,37GAB@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia S Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnD - - ko:K11785 ko00130,ko01110,map00130,map01110 - R08589 RC02330 ko00000,ko00001,ko01000 - - - VitK2_biosynth k59_221913_1 1380355.JNIJ01000050_gene130 3.07e-77 239.0 COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2TTC6@28211|Alphaproteobacteria,3JSJ8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1370960_1 589865.DaAHT2_2410 3.21e-17 80.9 COG0535@1|root,COG0535@2|Bacteria,1RADC@1224|Proteobacteria,42RDA@68525|delta/epsilon subdivisions,2WN4I@28221|Deltaproteobacteria,2MM5N@213118|Desulfobacterales 28221|Deltaproteobacteria C Iron-sulfur cluster-binding domain - - - - - - - - - - - - Fer4_14,Radical_SAM,SPASM k59_1370960_2 589865.DaAHT2_2411 4.97e-38 140.0 COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42PFW@68525|delta/epsilon subdivisions,2WJ1N@28221|Deltaproteobacteria,2MI4U@213118|Desulfobacterales 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,Radical_SAM k59_68709_1 288000.BBta_4887 8.44e-32 117.0 COG3258@1|root,COG3258@2|Bacteria,1QTYW@1224|Proteobacteria,2TWPT@28211|Alphaproteobacteria,3JVV3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrome_CBB3 k59_68709_2 547042.BACCOPRO_00394 2.34e-08 60.5 COG0526@1|root,COG0526@2|Bacteria,4NEX3@976|Bacteroidetes,2FN8N@200643|Bacteroidia,4AQ4F@815|Bacteroidaceae 976|Bacteroidetes CO Thioredoxin - - - - - - - - - - - - AhpC-TSA,DUF4369,Thioredoxin_8 k59_68709_3 472759.Nhal_3501 1.37e-07 55.5 COG2132@1|root,COG2132@2|Bacteria,1R7BF@1224|Proteobacteria,1S0VI@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase_2,Cu-oxidase_3 k59_484472_1 1122194.AUHU01000004_gene1633 2.57e-33 125.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,464AG@72275|Alteromonadaceae 1236|Gammaproteobacteria C CoA-transferase family III frc - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_484472_2 935567.JAES01000027_gene1290 2.72e-06 49.7 COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,1RMUX@1236|Gammaproteobacteria,1X3WV@135614|Xanthomonadales 135614|Xanthomonadales E Hydroxymethylglutaryl-CoA lyase mvaB - 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_379012_1 713587.THITH_14475 2.39e-06 49.7 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1WWI1@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_643367_1 330214.NIDE4287 2.16e-75 247.0 COG0205@1|root,COG0406@1|root,COG0205@2|Bacteria,COG0406@2|Bacteria 2|Bacteria G alpha-ribazole phosphatase activity pfkA - 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - His_Phos_1,PFK k59_1424522_1 545264.KB898754_gene1864 4.48e-45 158.0 COG0479@1|root,COG0479@2|Bacteria,1QVWG@1224|Proteobacteria,1RNMQ@1236|Gammaproteobacteria,1WYUM@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_22 k59_1270086_1 926566.Terro_3411 1.74e-06 49.3 COG0688@1|root,COG0688@2|Bacteria,3Y4AZ@57723|Acidobacteria,2JJ6I@204432|Acidobacteriia 204432|Acidobacteriia I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_1270086_2 1523503.JPMY01000011_gene817 7.62e-49 170.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_1270086_3 290398.Csal_2451 6.69e-30 116.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1XH6T@135619|Oceanospirillales 135619|Oceanospirillales CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_1478056_2 56780.SYN_01134 1.17e-29 119.0 COG2244@1|root,COG2244@2|Bacteria 2|Bacteria S polysaccharide biosynthetic process cps2I - - - - - - - - - - - Polysacc_synt,Polysacc_synt_C k59_326915_1 582744.Msip34_0329 3.13e-44 146.0 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2VR6I@28216|Betaproteobacteria,2KMTV@206350|Nitrosomonadales 206350|Nitrosomonadales J PFAM ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_326915_2 1123020.AUIE01000022_gene3153 1.14e-165 471.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1YCXZ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_326915_3 1163617.SCD_n00649 2.91e-85 256.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2VGZH@28216|Betaproteobacteria 28216|Betaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_274146_1 1056820.KB900699_gene1281 3.23e-16 76.6 COG1983@1|root,COG1983@2|Bacteria,1N085@1224|Proteobacteria,1S98J@1236|Gammaproteobacteria,2PQDE@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria KT PspC domain pspC GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0016020,GO:0019222,GO:0044464,GO:0048518,GO:0050789,GO:0060255,GO:0065007,GO:0071944 - ko:K03973 - - - - ko00000,ko02048,ko03000 - - - PspC k59_535030_1 321332.CYB_1145 3.81e-164 484.0 COG3957@1|root,COG3957@2|Bacteria,1G0B2@1117|Cyanobacteria,1GZSA@1129|Synechococcus 1117|Cyanobacteria G Phosphoketolase - - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_484483_1 1122247.C731_3136 3.68e-06 56.2 COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria,2362T@1762|Mycobacteriaceae 201174|Actinobacteria V beta-lactamase - - 3.4.16.4 ko:K01286 - - - - ko00000,ko01000 - - - Beta-lactamase k59_167541_1 1279038.KB907337_gene267 2.76e-65 209.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria,2JQNJ@204441|Rhodospirillales 204441|Rhodospirillales E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_379032_1 1265313.HRUBRA_01799 4.82e-20 85.9 COG4764@1|root,COG4764@2|Bacteria,1MVRK@1224|Proteobacteria,1RQ79@1236|Gammaproteobacteria,1J5V9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - SLT k59_587393_1 1279017.AQYJ01000028_gene2262 9.67e-55 184.0 28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,1RQUY@1236|Gammaproteobacteria,464CA@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1632534_1 765911.Thivi_3494 1.2e-113 352.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales 135613|Chromatiales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_901084_1 272562.CA_C0707 6.98e-06 55.1 COG1508@1|root,COG1508@2|Bacteria,1TQ0H@1239|Firmicutes,2480F@186801|Clostridia,36ENH@31979|Clostridiaceae 186801|Clostridia K RNA polymerase sigma54 factor rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_901888_1 243090.RB1431 7.19e-72 232.0 COG0651@1|root,COG0651@2|Bacteria,2IXRM@203682|Planctomycetes 203682|Planctomycetes CP Proton-conducting membrane transporter - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_1633441_1 765914.ThisiDRAFT_2021 4.54e-65 207.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1WW2U@135613|Chromatiales 135613|Chromatiales I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1633441_2 631362.Thi970DRAFT_04968 7.95e-12 65.1 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1WXGF@135613|Chromatiales 135613|Chromatiales E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_431360_1 95619.PM1_0217455 5.14e-131 381.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria 1236|Gammaproteobacteria K RNA polymerase sigma rpoS GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1633444_1 396588.Tgr7_1464 4.61e-53 179.0 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1WWK8@135613|Chromatiales 135613|Chromatiales S Belongs to the GcvT family - - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_855300_2 247634.GPB2148_693 1.39e-10 60.8 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1J4HN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1011534_1 570268.ANBB01000047_gene3927 1.03e-06 50.4 COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4EG2X@85012|Streptosporangiales 201174|Actinobacteria EH Thiamine pyrophosphate enzyme, central domain ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1432862_1 102129.Lepto7375DRAFT_7541 1.64e-45 156.0 COG1484@1|root,COG1484@2|Bacteria,1GBSA@1117|Cyanobacteria 1117|Cyanobacteria L PFAM IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_808963_1 1038859.AXAU01000028_gene23 4.96e-101 322.0 COG3889@1|root,COG3889@2|Bacteria,1R6EI@1224|Proteobacteria,2UQR6@28211|Alphaproteobacteria,3K2HR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - - - - - - - - - - - k59_1064523_1 472759.Nhal_0300 5.01e-83 250.0 COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,1RR4R@1236|Gammaproteobacteria,1WWMM@135613|Chromatiales 135613|Chromatiales S TIGRFAM channel protein, hemolysin III family - - - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII k59_907658_1 1117108.PAALTS15_19618 9.96e-36 136.0 COG0350@1|root,COG1600@1|root,COG0350@2|Bacteria,COG1600@2|Bacteria,1TP6Q@1239|Firmicutes,4HAEW@91061|Bacilli,26R4Y@186822|Paenibacillaceae 91061|Bacilli C Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated queG GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16,HEAT_2 k59_438086_1 526227.Mesil_1947 0.000246 47.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1WIRD@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Vitamin B12 dependent methionine synthase activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_750411_1 13689.BV96_04330 9.15e-54 185.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2K8FK@204457|Sphingomonadales 204457|Sphingomonadales C Aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_1166102_1 1380391.JIAS01000020_gene1609 1.24e-22 95.5 COG0730@1|root,COG0730@2|Bacteria,1NAFA@1224|Proteobacteria,2U1B5@28211|Alphaproteobacteria,2JT8C@204441|Rhodospirillales 204441|Rhodospirillales S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_1166102_2 1216976.AX27061_3155 4.32e-09 56.6 COG0028@1|root,COG0028@2|Bacteria,1MWUB@1224|Proteobacteria,2VMC1@28216|Betaproteobacteria,3T5NB@506|Alcaligenaceae 28216|Betaproteobacteria EH Belongs to the TPP enzyme family xsc - 2.3.3.15 ko:K03852 ko00430,map00430 - R05651 RC02903,RC02909 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_907663_1 348824.LPU83_3314 3.65e-13 72.8 COG2114@1|root,COG2114@2|Bacteria,1R4VB@1224|Proteobacteria,2TRX8@28211|Alphaproteobacteria,4B79H@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc k59_1011556_1 1205753.A989_13244 3.25e-05 48.5 COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,1X5K2@135614|Xanthomonadales 135614|Xanthomonadales S Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxH - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos,Metallophos_2 k59_1011556_2 335543.Sfum_1527 3.62e-15 75.9 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,42PNZ@68525|delta/epsilon subdivisions,2WM13@28221|Deltaproteobacteria,2MQS1@213462|Syntrophobacterales 28221|Deltaproteobacteria C CoA-transferase family III - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_1486583_1 330214.NIDE1215 1.66e-107 318.0 COG0407@1|root,COG0407@2|Bacteria,3J0C3@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_750418_1 1267534.KB906756_gene100 6.98e-10 59.3 COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria 2|Bacteria D von Willebrand factor, type A - - - - - - - - - - - - GATase1_like k59_593890_1 1220535.IMCC14465_17390 2.21e-61 211.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_77232_2 717773.Thicy_0336 9.87e-39 139.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,45ZU9@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_8845_1 1121430.JMLG01000003_gene623 3.47e-08 55.5 COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,260TC@186807|Peptococcaceae 186801|Clostridia M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_8845_2 321327.CYA_0196 5.01e-64 216.0 COG0769@1|root,COG0769@2|Bacteria,1G0HH@1117|Cyanobacteria,1GZ2T@1129|Synechococcus 1117|Cyanobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_651889_1 706587.Desti_3813 2.67e-46 167.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,42NMY@68525|delta/epsilon subdivisions,2WJ8S@28221|Deltaproteobacteria,2MR1Q@213462|Syntrophobacterales 28221|Deltaproteobacteria M Mur ligase family, catalytic domain mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1486605_1 330214.NIDE2074 1.94e-109 323.0 COG1697@1|root,COG1697@2|Bacteria 2|Bacteria L DNA topoisomerase VI subunit A top6A - 5.99.1.3 ko:K03166 - - - - ko00000,ko01000,ko03032 - - - DUF2220,DUF3322,TP6A_N k59_809006_1 1198232.CYCME_0049 9.38e-106 317.0 COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,1RSQ1@1236|Gammaproteobacteria,460MY@72273|Thiotrichales 72273|Thiotrichales S Zn-dependent protease - - - - - - - - - - - - Peptidase_M48 k59_1116474_1 502025.Hoch_4825 7.4e-38 146.0 COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,42YZ2@68525|delta/epsilon subdivisions,2WTQ1@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K02668,ko:K07709 ko02020,map02020 M00499,M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HAMP,HATPase_c,HisKA,PAS,PAS_10,PAS_4,PAS_9,sCache_3_2 k59_593907_3 658401.C7F4B8_9CAUD 2.69e-10 63.9 4QH5W@10239|Viruses,4QYFG@35237|dsDNA viruses no RNA stage,4QQD8@28883|Caudovirales,4QN2T@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_1586187_1 997346.HMPREF9374_3885 2.15e-37 132.0 COG0346@1|root,COG0346@2|Bacteria,1V36W@1239|Firmicutes,4IQ29@91061|Bacilli 91061|Bacilli E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K07032 - - - - ko00000 - - - Glyoxalase k59_1586187_3 349521.HCH_01738 1.27e-13 67.4 COG4067@1|root,COG4067@2|Bacteria,1RGX8@1224|Proteobacteria,1S5YR@1236|Gammaproteobacteria,1XKPE@135619|Oceanospirillales 135619|Oceanospirillales O protein conserved in archaea - - - - - - - - - - - - Zn_protease k59_958817_1 305900.GV64_22125 1.06e-39 144.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1XJ25@135619|Oceanospirillales 135619|Oceanospirillales S Protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD pmbA - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_958817_2 488538.SAR116_2475 3.88e-06 48.1 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,4BPDB@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_1278887_1 1267535.KB906767_gene1612 2.43e-19 96.7 COG0612@1|root,COG0612@2|Bacteria,3Y3M9@57723|Acidobacteria,2JHY4@204432|Acidobacteriia 204432|Acidobacteriia S Belongs to the peptidase M16 family - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_750452_1 471854.Dfer_0310 7.92e-48 162.0 COG0656@1|root,COG0656@2|Bacteria,4NK47@976|Bacteroidetes,47MZY@768503|Cytophagia 976|Bacteroidetes S Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_77268_1 1203554.HMPREF1476_01492 8.54e-67 222.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,4PQ83@995019|Sutterellaceae 28216|Betaproteobacteria O Cytochrome c-type biogenesis protein CcmF C-terminal ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_1432937_1 395493.BegalDRAFT_3163 3.92e-69 233.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,45ZXM@72273|Thiotrichales 72273|Thiotrichales C 2-oxoglutarate dehydrogenase, E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_8877_1 1403819.BATR01000137_gene4864 2.01e-31 124.0 2ECB1@1|root,3369C@2|Bacteria,46WPZ@74201|Verrucomicrobia,2IW2Q@203494|Verrucomicrobiae 203494|Verrucomicrobiae - - - - - - - - - - - - - - - k59_387833_1 266117.Rxyl_2529 4.83e-79 266.0 COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4CPJ1@84995|Rubrobacteria 84995|Rubrobacteria E Bacterial NAD-glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_809043_1 314230.DSM3645_20022 1.53e-17 80.1 COG0106@1|root,COG0106@2|Bacteria,2IYYG@203682|Planctomycetes 203682|Planctomycetes E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_959582_1 1121382.JQKG01000003_gene4241 8.9e-52 186.0 COG3525@1|root,COG3525@2|Bacteria,1WM5J@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G beta-N-acetylglucosaminidase - - - - - - - - - - - - NAGidase k59_1280365_1 1318628.MARLIPOL_13884 3.64e-29 116.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RNWM@1236|Gammaproteobacteria,465X0@72275|Alteromonadaceae 1236|Gammaproteobacteria S exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1280365_2 765912.Thimo_2752 1.59e-07 54.7 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,1RNJW@1236|Gammaproteobacteria,1WXHN@135613|Chromatiales 135613|Chromatiales Q PFAM toluene tolerance - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_1487986_1 378806.STAUR_5933 3.06e-41 160.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2YUHY@29|Myxococcales 28221|Deltaproteobacteria M penicillin-binding protein mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_1377991_1 66875.JODY01000006_gene2209 8.47e-36 135.0 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria 201174|Actinobacteria J Belongs to the amidase family amiC_1 - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_1377991_3 1123242.JH636434_gene4155 2.89e-20 92.8 COG3379@1|root,COG3379@2|Bacteria,2IXA8@203682|Planctomycetes 203682|Planctomycetes S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_701206_1 269799.Gmet_0448 1.45e-21 94.4 COG1449@1|root,COG1449@2|Bacteria,1R51R@1224|Proteobacteria,42P4W@68525|delta/epsilon subdivisions,2WK2R@28221|Deltaproteobacteria,43U1D@69541|Desulfuromonadales 28221|Deltaproteobacteria G Glycosyl hydrolase family 57 - - - - - - - - - - - - Glyco_hydro_57 k59_438900_1 679897.HMU04360 2.13e-13 69.7 COG0355@1|root,COG0355@2|Bacteria 2|Bacteria C proton-transporting ATP synthase activity, rotational mechanism atpC GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02113,ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N k59_438900_2 1121413.JMKT01000008_gene1469 4.37e-160 461.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,42KZA@68525|delta/epsilon subdivisions,2WJ1V@28221|Deltaproteobacteria,2M86R@213115|Desulfovibrionales 28221|Deltaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_1117324_2 1089552.KI911559_gene2131 5.57e-32 125.0 COG1129@1|root,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2TW58@28211|Alphaproteobacteria,2JPP0@204441|Rhodospirillales 204441|Rhodospirillales V transporter, ATP-binding protein - - - ko:K13926 - - - - ko00000 - - - ABC2_membrane_3,ABC_tran k59_908628_1 314287.GB2207_06084 2.44e-24 108.0 COG3391@1|root,COG3391@2|Bacteria,1QYUP@1224|Proteobacteria 1224|Proteobacteria EH HYR domain - - - - - - - - - - - - HYR k59_751315_1 330214.NIDE1063 8.18e-114 343.0 COG0422@1|root,COG0422@2|Bacteria,3J0AY@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC_Rad_SAM k59_751315_2 330214.NIDE1062 8.19e-20 85.5 COG1635@1|root,COG1635@2|Bacteria 2|Bacteria H Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur thi4 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0018131,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0046872,GO:0046914,GO:0052837,GO:0052838,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - ko:K03146 ko00730,ko01100,map00730,map01100 - R10685 RC00033,RC03253,RC03254 ko00000,ko00001 - - - FAD_oxidored,Thi4 k59_1323186_1 688270.Celal_2384 2.53e-13 82.8 COG2931@1|root,COG3210@1|root,COG3420@1|root,COG4935@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3420@2|Bacteria,COG4935@2|Bacteria,4PNSZ@976|Bacteroidetes,1IKBE@117743|Flavobacteriia,1F8UJ@104264|Cellulophaga 976|Bacteroidetes PQU SdrD B-like domain - - - - - - - - - - - - Beta_helix,CUB,Calx-beta,SdrD_B k59_334276_1 396588.Tgr7_0122 1.42e-148 432.0 COG1488@1|root,COG1488@2|Bacteria 2|Bacteria H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP pncB GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - iYO844.BSU31750 NAPRTase k59_1528601_1 765913.ThidrDRAFT_0850 3.72e-20 94.4 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria,1WXUR@135613|Chromatiales 135613|Chromatiales P PFAM Na Picotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_908630_1 713586.KB900536_gene2239 2.31e-107 317.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1WX13@135613|Chromatiales 135613|Chromatiales H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas k59_1488013_1 391615.ABSJ01000042_gene2194 1.7e-27 116.0 COG4254@1|root,COG4254@2|Bacteria,1RJR0@1224|Proteobacteria,1S8WR@1236|Gammaproteobacteria,1JBNT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S FecR protein - - - - - - - - - - - - FecR k59_78685_1 255470.cbdbA1487 6.53e-91 273.0 COG2801@1|root,COG2801@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia 301297|Dehalococcoidia L PFAM Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_388726_2 403833.Pmob_1005 0.00072 41.6 COG0740@1|root,COG0740@2|Bacteria,2GC7E@200918|Thermotogae 200918|Thermotogae O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_1166824_1 380358.XALC_2576 7.97e-09 56.2 COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S953@1236|Gammaproteobacteria,1X35M@135614|Xanthomonadales 135614|Xanthomonadales S protein conserved in bacteria - - - ko:K09921 - - - - ko00000 - - - DUF484 k59_1166824_2 1175306.GWL_36810 4.53e-09 60.5 COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,2WI50@28216|Betaproteobacteria,4794G@75682|Oxalobacteraceae 28216|Betaproteobacteria D Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_1587077_1 583345.Mmol_2231 1.28e-83 270.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,2KKM5@206350|Nitrosomonadales 206350|Nitrosomonadales S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48,TPR_19 k59_1323196_2 330214.NIDE1575 9.98e-40 141.0 COG2215@1|root,COG2215@2|Bacteria 2|Bacteria O Belongs to the NiCoT transporter (TC 2.A.52) family ureH - - - - - - - - - - - DsbD_2,NicO k59_1280407_1 316067.Geob_2465 0.00053 47.8 COG2834@1|root,COG2834@2|Bacteria 2|Bacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - - - - - - - - - - DUF1329,DUF4367,LolA_like,MucB_RseB,Sigma70_r2,Sigma70_r4_2 k59_9615_1 439235.Dalk_4838 0.00034 45.1 COG0455@1|root,COG2214@1|root,COG0455@2|Bacteria,COG2214@2|Bacteria,1R8IW@1224|Proteobacteria,42R3H@68525|delta/epsilon subdivisions,2WMNY@28221|Deltaproteobacteria,2MKRR@213118|Desulfobacterales 28221|Deltaproteobacteria D NUBPL iron-transfer P-loop NTPase - - - ko:K04562 - - - - ko00000,ko02035 - - - CbiA,ParA k59_78698_1 743299.Acife_0890 3.02e-109 335.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1S1ID@1236|Gammaproteobacteria,2NC8Z@225057|Acidithiobacillales 225057|Acidithiobacillales P copper-translocating P-type ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase k59_1280421_1 909663.KI867150_gene1303 5.41e-83 275.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2MR0B@213462|Syntrophobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1065449_1 1049564.TevJSym_aw00100 2.84e-70 221.0 COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,1RRYZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein dsrO - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11,Fer4_7 k59_653374_1 1049564.TevJSym_ag00550 1.11e-27 103.0 2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SD3Y@1236|Gammaproteobacteria,1J6YA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_173902_1 870187.Thini_3621 5.79e-62 192.0 28PZA@1|root,2ZCIS@2|Bacteria,1RCMD@1224|Proteobacteria,1SEW0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1231457_1 713586.KB900536_gene177 2.31e-119 359.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1WW67@135613|Chromatiales 135613|Chromatiales M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_1592241_1 1177154.Y5S_01713 2.8e-75 253.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,1XI5R@135619|Oceanospirillales 135619|Oceanospirillales S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16 k59_817122_1 1120959.ATXF01000007_gene2169 5.14e-12 71.6 2CA6S@1|root,2Z9P6@2|Bacteria,2IAT3@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_132315_1 224911.27350975 9.88e-45 159.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,3JRJV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E GMC oxidoreductase MA20_17575 - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_132315_2 997296.PB1_16744 3.56e-30 115.0 COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,4HII3@91061|Bacilli,1ZFSI@1386|Bacillus 91061|Bacilli F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS08510 CoaE k59_706099_1 314278.NB231_03962 1.96e-18 91.7 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1WX8M@135613|Chromatiales 135613|Chromatiales NU Tfp pilus assembly protein, tip-associated adhesin PilY1 - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_339306_1 395494.Galf_0178 1.06e-36 133.0 293CN@1|root,2ZQV6@2|Bacteria,1QVH7@1224|Proteobacteria,2WGR5@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_660085_1 323261.Noc_2682 1.07e-33 130.0 COG3829@1|root,COG5001@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_9 k59_287103_1 1318628.MARLIPOL_02480 2.25e-39 132.0 COG3526@1|root,COG3526@2|Bacteria,1MZ5V@1224|Proteobacteria,1S8S8@1236|Gammaproteobacteria,468BE@72275|Alteromonadaceae 1236|Gammaproteobacteria O protein conserved in bacteria - - - ko:K07401 - - - - ko00000 - - - Rdx k59_132341_1 402881.Plav_2411 3.45e-107 319.0 COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2U14P@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Alcohol dehydrogenase zinc-binding domain protein - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_599914_1 1122132.AQYH01000010_gene3786 4.19e-11 61.6 COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,2U7UT@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG2111 Multisubunit Na H antiporter, MnhB subunit - - - ko:K05566 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040 k59_599914_2 1304888.ATWF01000002_gene128 5.62e-19 83.6 COG2111@1|root,COG2111@2|Bacteria,2GFXF@200930|Deferribacteres 200930|Deferribacteres P Domain related to MnhB subunit of Na+/H+ antiporter - - - ko:K05566 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MnhB k59_1287189_1 1129794.C427_5467 4.44e-10 60.1 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,46554@72275|Alteromonadaceae 1236|Gammaproteobacteria S hydrolase of the alpha beta-hydrolase fold yheT GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0050526,GO:0052689,GO:0071704 - ko:K07019 - - - - ko00000 - - - Abhydrolase_1 k59_1017666_1 765913.ThidrDRAFT_0707 2.17e-88 272.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1WX4Z@135613|Chromatiales 135613|Chromatiales S AI-2E family transporter - - - ko:K03548 - - - - ko00000,ko02000 2.A.86.1 - - AI-2E_transport k59_861435_1 1535422.ND16A_1247 3.52e-292 840.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1231513_1 977880.RALTA_A0971 1.48e-14 73.6 COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2VI8J@28216|Betaproteobacteria,1K4EB@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM FAD linked oxidase domain protein - - - - - - - - - - - - BBE,FAD_binding_4 k59_393421_1 224719.Abm4_1630 4.01e-11 67.8 COG1035@1|root,arCOG02651@2157|Archaea,2XUH6@28890|Euryarchaeota,23NWU@183925|Methanobacteria 183925|Methanobacteria C PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit frhB1 - 1.12.98.1 ko:K00441 ko00680,ko01100,ko01120,map00680,map01100,map01120 - R03025 RC02628 ko00000,ko00001,ko01000 - - - FrhB_FdhB_C,FrhB_FdhB_N k59_661137_1 1268303.RHODMAR_4111 1.16e-07 52.4 COG1028@1|root,COG1028@2|Bacteria,2IAK8@201174|Actinobacteria,4G143@85025|Nocardiaceae 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_661137_2 886293.Sinac_1681 3.94e-26 109.0 COG2358@1|root,COG2358@2|Bacteria,2IY5Z@203682|Planctomycetes 203682|Planctomycetes S NMT1-like family - - - - - - - - - - - - NMT1_3 k59_133197_1 1121422.AUMW01000017_gene1971 7.5e-52 174.0 COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,248Z4@186801|Clostridia,26736@186807|Peptococcaceae 186801|Clostridia T response regulator receiver walR - - ko:K07658,ko:K07668 ko02020,map02020 M00434,M00459 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_133197_2 690850.Desaf_3046 1.54e-05 50.4 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,2M83V@213115|Desulfovibrionales 28221|Deltaproteobacteria T Signal transducing histidine kinase homodimeric cheA34H - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_133197_3 526225.Gobs_4657 2.71e-17 82.0 COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4ERG0@85013|Frankiales 201174|Actinobacteria T Two component transcriptional regulator, winged helix family phoP - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_502289_1 1121948.AUAC01000008_gene823 1.78e-54 186.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,43X4S@69657|Hyphomonadaceae 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_287874_1 97096.XP_007797560.1 6.54e-21 90.9 COG0302@1|root,KOG2698@2759|Eukaryota,38CYY@33154|Opisthokonta,3NVRA@4751|Fungi,3QP0W@4890|Ascomycota,214NU@147550|Sordariomycetes 4751|Fungi H GTP cyclohydrolase - GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006066,GO:0006082,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046394,GO:0046483,GO:0046655,GO:0046656,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - iMM904.YGR267C,iND750.YGR267C GTP_cyclohydroI k59_287874_2 1235792.C808_03593 7.6e-27 110.0 COG1028@1|root,COG1028@2|Bacteria,1TSND@1239|Firmicutes,24DU0@186801|Clostridia,27RX9@186928|unclassified Lachnospiraceae 186801|Clostridia IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short,adh_short_C2 k59_86317_1 1267535.KB906767_gene5095 2.63e-12 66.6 COG2957@1|root,COG2957@2|Bacteria,3Y2W5@57723|Acidobacteria,2JIKF@204432|Acidobacteriia 204432|Acidobacteriia E Belongs to the agmatine deiminase family - - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph k59_86317_2 1123024.AUII01000011_gene4422 5e-141 417.0 COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4DZPA@85010|Pseudonocardiales 201174|Actinobacteria C succinate dehydrogenase frdA GO:0000104,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0022900,GO:0032991,GO:0044237,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803 1.3.5.1,1.3.5.4,1.4.3.16 ko:K00239,ko:K00244,ko:K00278 ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00115,M00149,M00150,M00173,M00374,M00376 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv1552 FAD_binding_2,Succ_DH_flav_C k59_1592945_1 1137799.GZ78_26480 6.51e-24 105.0 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1XIW5@135619|Oceanospirillales 135619|Oceanospirillales NU Tfp pilus assembly protein - - - ko:K08086 - - - - ko00000 - - - LysM,TPR_19 k59_547771_1 445686.E3SL91_9CAUD 4.32e-82 254.0 4QCGC@10239|Viruses,4QZFA@35237|dsDNA viruses no RNA stage,4QTZH@28883|Caudovirales,4QJ8J@10662|Myoviridae 10662|Myoviridae S Domain of unknown function (DUF4338) - - - - - - - - - - - - - k59_1495743_1 994479.GL877879_gene5771 2.06e-65 215.0 COG0028@1|root,COG0028@2|Bacteria,2GN3X@201174|Actinobacteria,4DZWK@85010|Pseudonocardiales 201174|Actinobacteria EH PFAM Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_N k59_965624_1 1038867.AXAY01000008_gene541 1.64e-61 210.0 COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2TRRK@28211|Alphaproteobacteria,3JWB5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Coenzyme A transferase pct - 2.8.3.1 ko:K01026 ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120 - R00928,R01449,R05508 RC00012,RC00014,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_234816_1 1163407.UU7_11265 9.51e-66 219.0 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1X53W@135614|Xanthomonadales 135614|Xanthomonadales S L,D-transpeptidase catalytic domain - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_706897_1 110319.CF8_3008 5.56e-19 89.4 COG0340@1|root,COG0340@2|Bacteria,2GN8Q@201174|Actinobacteria,4DQT5@85009|Propionibacteriales 201174|Actinobacteria H Biotin/lipoate A/B protein ligase family birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB k59_706897_2 330214.NIDE1730 1.35e-31 118.0 COG1521@1|root,COG1521@2|Bacteria,3J0TR@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k59_1171633_2 904314.SEVCU012_1012 7.79e-08 53.1 COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,4HATK@91061|Bacilli,4GYQF@90964|Staphylococcaceae 91061|Bacilli I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabHB GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0071704 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_1495749_1 395495.Lcho_3193 3.26e-50 167.0 COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,2VK1C@28216|Betaproteobacteria,1KKI4@119065|unclassified Burkholderiales 28216|Betaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_1495749_2 392499.Swit_0205 2.45e-20 85.5 COG0662@1|root,COG0662@2|Bacteria,1N71F@1224|Proteobacteria,2UFSH@28211|Alphaproteobacteria,2KBHV@204457|Sphingomonadales 204457|Sphingomonadales G Cupin domain - - - - - - - - - - - - Cupin_2 k59_1441929_1 1479237.JMLY01000001_gene2107 5.36e-24 98.6 COG3713@1|root,COG3713@2|Bacteria,1QSEK@1224|Proteobacteria,1RNGI@1236|Gammaproteobacteria,465W1@72275|Alteromonadaceae 1236|Gammaproteobacteria M MltA-interacting MipA family protein - - - - - - - - - - - - MipA k59_1327979_1 519989.ECTPHS_02641 1.91e-44 148.0 COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,1S92I@1236|Gammaproteobacteria,1WYCK@135613|Chromatiales 135613|Chromatiales M Recycling of diacylglycerol produced during the turnover of membrane phospholipid - - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar k59_1327979_2 485915.Dret_1022 1.94e-12 68.2 COG3528@1|root,COG3528@2|Bacteria,1R601@1224|Proteobacteria,42Q98@68525|delta/epsilon subdivisions,2WM5S@28221|Deltaproteobacteria,2MA0W@213115|Desulfovibrionales 28221|Deltaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2219) - - - - - - - - - - - - DUF2219 k59_1232376_1 926566.Terro_0847 2.76e-15 78.2 COG1403@1|root,COG1403@2|Bacteria,3Y500@57723|Acidobacteria,2JJK7@204432|Acidobacteriia 204432|Acidobacteriia L HNH nucleases - - - - - - - - - - - - HNH k59_393445_1 1379270.AUXF01000006_gene27 2.49e-39 141.0 COG0142@1|root,COG0142@2|Bacteria,1ZT7D@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Polyprenyl synthetase - - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_1018377_1 78245.Xaut_1358 2.99e-26 107.0 COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,3F1JV@335928|Xanthobacteraceae 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1018377_2 314264.ROS217_20032 3.92e-26 103.0 COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2VGRS@28211|Alphaproteobacteria 28211|Alphaproteobacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA - - - - - - - - - - - - Biotin_lipoyl k59_502328_1 472759.Nhal_2791 4.75e-22 96.3 COG2885@1|root,COG2885@2|Bacteria,1REH1@1224|Proteobacteria,1S4WV@1236|Gammaproteobacteria,1WZ8J@135613|Chromatiales 135613|Chromatiales M Belongs to the ompA family - - - - - - - - - - - - DUF4398,OmpA k59_287898_2 269796.Rru_A1349 1.47e-23 102.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TQWP@28211|Alphaproteobacteria,2JQ0B@204441|Rhodospirillales 204441|Rhodospirillales E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_600783_1 1379698.RBG1_1C00001G0296 8.19e-58 188.0 COG0437@1|root,COG0437@2|Bacteria,2NR78@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S binding domain ttrB - - ko:K08358 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Fer4_11,Fer4_3,Fer4_7 k59_1123346_1 1121405.dsmv_3691 1.02e-76 241.0 COG3547@1|root,COG3547@2|Bacteria,1NP2U@1224|Proteobacteria,43A5Q@68525|delta/epsilon subdivisions,2X2AM@28221|Deltaproteobacteria,2MPDW@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - - k59_1288280_1 436308.Nmar_0871 1.8e-198 557.0 COG0017@1|root,arCOG00406@2157|Archaea,41SBT@651137|Thaumarchaeota 651137|Thaumarchaeota J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) - - 6.1.1.23 ko:K09759 ko00970,map00970 M00360 R03647,R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_1495783_2 1380394.JADL01000012_gene856 2.49e-50 176.0 28JZQ@1|root,2Z9PN@2|Bacteria,1N2WN@1224|Proteobacteria,2U0QD@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1123349_1 243231.GSU2574 2.81e-33 129.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42QAG@68525|delta/epsilon subdivisions,2X5DT@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Response regulator receiver - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg k59_1018385_1 1123070.KB899269_gene2392 8.08e-101 313.0 COG0480@1|root,COG0480@2|Bacteria,46TP0@74201|Verrucomicrobia,2IU37@203494|Verrucomicrobiae 203494|Verrucomicrobiae J Elongation factor G, domain IV - - - - - - - - - - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1288281_1 251229.Chro_3041 9.57e-44 153.0 COG3001@1|root,COG3001@2|Bacteria,1G040@1117|Cyanobacteria,3VJB7@52604|Pleurocapsales 1117|Cyanobacteria G PFAM Fructosamine kinase - GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 - - - - - - - - - - Fructosamin_kin k59_818356_1 1384054.N790_11475 8.18e-24 104.0 COG1524@1|root,COG1524@2|Bacteria,1N5SF@1224|Proteobacteria,1RS7W@1236|Gammaproteobacteria,1X350@135614|Xanthomonadales 135614|Xanthomonadales S proteins of the AP superfamily - - - - - - - - - - - - Phosphodiest k59_1649032_1 305700.B447_17861 1.55e-19 85.5 COG2030@1|root,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2VREB@28216|Betaproteobacteria,2KWED@206389|Rhodocyclales 206389|Rhodocyclales I N-terminal half of MaoC dehydratase - - 4.2.1.55 ko:K17865 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R03027 RC00831 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydratas k59_706935_1 1121921.KB898708_gene1582 3.57e-70 228.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,2PMMZ@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M Lysin motif mltD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009 - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_133252_1 1123508.JH636439_gene1131 0.000529 48.1 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Big_5,VCBS k59_547819_1 649638.Trad_0146 2.77e-19 92.0 COG1957@1|root,COG1957@2|Bacteria 2|Bacteria F ribosylpyrimidine nucleosidase activity - - - - - - - - - - - - IU_nuc_hydro k59_393464_1 998674.ATTE01000001_gene152 1.93e-81 254.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,45ZRJ@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_393464_2 1343739.PAP_01860 1.4e-37 128.0 COG2343@1|root,arCOG06569@2157|Archaea,2Y5DB@28890|Euryarchaeota 28890|Euryarchaeota S Domain of unknown function (DUF427) - - - - - - - - - - - - NTP_transf_9 k59_393464_3 768671.ThimaDRAFT_2385 1.19e-53 172.0 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,1WY9X@135613|Chromatiales 135613|Chromatiales S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_393464_4 1123279.ATUS01000005_gene3283 7.83e-05 46.2 COG4446@1|root,COG4446@2|Bacteria,1N31A@1224|Proteobacteria,1RRKY@1236|Gammaproteobacteria,1JADN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1499) - - - - - - - - - - - - DUF1499 k59_1592991_1 224911.27352823 7.07e-12 64.3 COG3812@1|root,COG3812@2|Bacteria,1MWRC@1224|Proteobacteria,2TTTM@28211|Alphaproteobacteria,3JW2S@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF1993) - - - ko:K09983 - - - - ko00000 - - - DUF1993 k59_1592991_2 1168065.DOK_10522 1.46e-85 261.0 COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,1RNSP@1236|Gammaproteobacteria,1J8V0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Endonuclease/Exonuclease/phosphatase family ybhP - - - - - - - - - - - Exo_endo_phos k59_818368_1 330214.NIDE4158 2.41e-55 194.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,3J0DP@40117|Nitrospirae 40117|Nitrospirae L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A k59_1533542_1 1131269.AQVV01000030_gene274 3.85e-66 211.0 COG0668@1|root,COG0668@2|Bacteria 2|Bacteria M transmembrane transport ynaI GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944 - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_1533542_2 983545.Glaag_0211 4.36e-38 137.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,464H0@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_4494 DAP_epimerase k59_706944_1 106370.Francci3_1241 7.72e-35 127.0 COG0491@1|root,COG0491@2|Bacteria,2GNS6@201174|Actinobacteria 201174|Actinobacteria P PFAM Metallo-beta-lactamase superfamily gloB GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006090,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019184,GO:0019752,GO:0031974,GO:0032787,GO:0034641,GO:0042398,GO:0043043,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051186,GO:0051188,GO:0070013,GO:0071704,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - Lactamase_B k59_706944_2 1452535.JARD01000022_gene3298 1.18e-09 61.2 COG3571@1|root,COG3571@2|Bacteria,2GKKE@201174|Actinobacteria,4FPN5@85023|Microbacteriaceae 201174|Actinobacteria S Dienelactone hydrolase family - - - ko:K07020 - - - - ko00000 - - - DLH k59_340225_1 1249627.D779_4132 2.01e-25 105.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1WWGK@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase, dimerisation - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_1328016_1 679935.Alfi_1683 4.97e-11 64.7 COG0137@1|root,COG0137@2|Bacteria,4NE3R@976|Bacteroidetes,2FMRA@200643|Bacteroidia,22UZN@171550|Rikenellaceae 976|Bacteroidetes E Arginosuccinate synthase argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_1328016_2 1121920.AUAU01000010_gene48 7.04e-47 163.0 COG0132@1|root,COG0132@2|Bacteria 2|Bacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.21,6.3.2.3,6.3.3.3 ko:K00857,ko:K01920,ko:K01935 ko00240,ko00270,ko00480,ko00780,ko00983,ko01100,map00240,map00270,map00480,map00780,map00983,map01100 M00118,M00123,M00573,M00577 R00497,R01567,R02099,R03182,R08233,R10994 RC00002,RC00017,RC00096,RC00141,RC00868 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,TK k59_1018408_1 243159.AFE_0233 1.93e-19 90.9 COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,1RRUD@1236|Gammaproteobacteria,2NCU8@225057|Acidithiobacillales 225057|Acidithiobacillales S Glycosyltransferase like family 2 - - - ko:K07011 - - - - ko00000 - - - Glyco_tranf_2_3,Glycos_transf_2 k59_1495819_1 1144305.PMI02_00153 6.68e-59 205.0 COG0318@1|root,COG0318@2|Bacteria,1NTR7@1224|Proteobacteria,2UPRR@28211|Alphaproteobacteria,2K8P4@204457|Sphingomonadales 204457|Sphingomonadales IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_93896_1 1232410.KI421421_gene3541 3.38e-20 86.3 COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,42WGY@68525|delta/epsilon subdivisions,2WS4W@28221|Deltaproteobacteria,43VDK@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tellurite resistance protein TerB - - - - - - - - - - - - TerB k59_972320_2 1525715.IX54_05235 2.21e-37 132.0 COG2010@1|root,COG2010@2|Bacteria,1RGXM@1224|Proteobacteria,2U95Y@28211|Alphaproteobacteria,2PXGV@265|Paracoccus 28211|Alphaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III cytC - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_972320_3 215803.DB30_4052 2.75e-45 167.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42QKW@68525|delta/epsilon subdivisions,2WKH1@28221|Deltaproteobacteria,2YWTQ@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_670646_1 911045.PSE_0439 1.15e-147 424.0 COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2TT4V@28211|Alphaproteobacteria 28211|Alphaproteobacteria EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_923636_1 288000.BBta_p0171 4.98e-81 251.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,2TQSJ@28211|Alphaproteobacteria,3JRGA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O hydrogenase expression formation protein - - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_1598920_1 436308.Nmar_0219 3.79e-59 194.0 arCOG08635@1|root,arCOG08635@2157|Archaea,41T54@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_763355_1 396588.Tgr7_0678 2.73e-137 396.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1WWM6@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_923646_2 1307437.J139_03600 1.14e-38 146.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2PZF3@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_16179_1 1348114.OM33_21025 2.14e-22 98.6 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,2Q0IU@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_16179_2 1218084.BBJK01000003_gene496 3.76e-33 120.0 COG3832@1|root,COG3832@2|Bacteria,1REDB@1224|Proteobacteria,2VXCY@28216|Betaproteobacteria,1KHJ0@119060|Burkholderiaceae 28216|Betaproteobacteria S Polyketide cyclase / dehydrase and lipid transport - - - ko:K16260 ko00680,ko01120,map00680,map01120 - - - ko00000,ko00001 - - - Polyketide_cyc2 k59_1539393_1 1229909.NSED_03625 3.62e-32 119.0 arCOG04054@1|root,arCOG04054@2157|Archaea,41SIQ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1539393_2 1229909.NSED_03620 2.77e-58 181.0 arCOG08659@1|root,arCOG08659@2157|Archaea,41T5K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1539393_3 1229909.NSED_03615 1.04e-14 72.8 COG1351@1|root,arCOG01884@2157|Archaea,41SF6@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - - - - - - - - - - Thy1 k59_1505284_2 404589.Anae109_4467 3.67e-69 219.0 COG1100@1|root,COG1100@2|Bacteria,1RCJJ@1224|Proteobacteria,42R57@68525|delta/epsilon subdivisions,2WN5Y@28221|Deltaproteobacteria,2YUYK@29|Myxococcales 28221|Deltaproteobacteria S Small GTP-binding protein - - - ko:K06883 - - - - ko00000 - - - Arf k59_95240_1 1266925.JHVX01000008_gene368 7.36e-88 276.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,371S5@32003|Nitrosomonadales 28216|Betaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_454534_1 1303692.SFUL_2902 1.56e-47 161.0 COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - 1.1.1.53 ko:K00038 ko00140,ko01100,map00140,map01100 - R04831,R04834,R04844,R04847 RC00139,RC01219,RC01220 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_511879_1 395019.Bmul_0487 1.93e-20 91.7 COG3637@1|root,COG3637@2|Bacteria,1N7IC@1224|Proteobacteria,2VVZ0@28216|Betaproteobacteria,1K72N@119060|Burkholderiaceae 28216|Betaproteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety pagL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008653,GO:0009279,GO:0009311,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0016788,GO:0019637,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0042802,GO:0042803,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044462,GO:0044464,GO:0046493,GO:0046983,GO:0050528,GO:0052689,GO:0071704,GO:0071944,GO:1901135,GO:1901269,GO:1903509 - ko:K12976 - - - - ko00000,ko01000,ko01005 - - - PagL k59_95243_1 247490.KSU1_C1324 1.35e-42 160.0 COG1957@1|root,COG3055@1|root,COG3204@1|root,COG4932@1|root,COG1957@2|Bacteria,COG3055@2|Bacteria,COG3204@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - - ko:K02674,ko:K07004 - - - - ko00000,ko02035,ko02044 - - - DUF547,Laminin_G_3,Malectin k59_1297669_1 876044.IMCC3088_71 9.06e-54 187.0 28HMZ@1|root,2Z7WD@2|Bacteria 2|Bacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1024785_1 716544.wcw_1107 4.75e-06 48.9 COG1212@1|root,COG1212@2|Bacteria,2JFZ3@204428|Chlamydiae 204428|Chlamydiae F Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria - - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_1658579_1 243159.AFE_2856 2.28e-38 140.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,2NBU6@225057|Acidithiobacillales 225057|Acidithiobacillales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_1658579_2 1116472.MGMO_5c00100 7.9e-18 84.7 COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1XDJP@135618|Methylococcales 135618|Methylococcales S PFAM Cytochrome c assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_606633_1 247633.GP2143_13266 7.71e-12 67.4 COG1011@1|root,COG1011@2|Bacteria,1QFFB@1224|Proteobacteria,1S4NP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_606633_2 1123279.ATUS01000001_gene2262 9.78e-86 265.0 COG4221@1|root,COG4221@2|Bacteria,1PH8K@1224|Proteobacteria,1RPDR@1236|Gammaproteobacteria,1J7QY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_670695_1 1121861.KB899918_gene3295 1.62e-74 239.0 COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,2JTNS@204441|Rhodospirillales 204441|Rhodospirillales S MmgE/PrpD family - - - - - - - - - - - - MmgE_PrpD k59_141458_1 1122135.KB893134_gene3933 6.39e-81 248.0 COG0518@1|root,COG0518@2|Bacteria,1Q2PQ@1224|Proteobacteria,2U196@28211|Alphaproteobacteria 28211|Alphaproteobacteria F glutamine amidotransferase - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase k59_141458_2 1122135.KB893134_gene3934 4.99e-38 134.0 COG1011@1|root,COG1011@2|Bacteria 2|Bacteria S phosphatase activity - - 3.1.3.10 ko:K07025,ko:K20866 ko00010,ko01120,map00010,map01120 - R00947 RC00078 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase,Hydrolase_like k59_511907_1 290397.Adeh_2651 9.84e-60 200.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Y98@68525|delta/epsilon subdivisions,2WTXU@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_763389_1 338966.Ppro_0642 9.11e-97 308.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,43TQ2@69541|Desulfuromonadales 28221|Deltaproteobacteria H Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1539415_1 1499967.BAYZ01000152_gene1383 1.3e-47 173.0 COG3437@1|root,COG5002@1|root,COG3437@2|Bacteria,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity - - 2.7.13.3 ko:K07814,ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_606638_1 330214.NIDE0690 1.19e-109 335.0 COG4772@1|root,COG4772@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_868480_2 555500.I215_10515 1.03e-30 121.0 COG5557@1|root,COG5557@2|Bacteria,4NE3X@976|Bacteroidetes,1HY9P@117743|Flavobacteriia 976|Bacteroidetes C Polysulphide reductase nrfD - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_511917_1 2325.TKV_c08950 1.49e-15 74.7 COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,24GFQ@186801|Clostridia,42G1K@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE - 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE k59_511917_2 396014.BF93_18045 2.1e-09 58.9 COG0135@1|root,COG0135@2|Bacteria,2IHPP@201174|Actinobacteria 201174|Actinobacteria E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_399637_1 452638.Pnec_1383 0.00026 43.5 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2VMGA@28216|Betaproteobacteria,1K840@119060|Burkholderiaceae 28216|Betaproteobacteria O once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran k59_399637_2 395494.Galf_1772 2.06e-71 222.0 COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2VNPU@28216|Betaproteobacteria,44VAM@713636|Nitrosomonadales 28216|Betaproteobacteria O Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmB - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB k59_511920_1 69395.JQLZ01000007_gene1764 6.72e-19 90.5 COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1QV6D@1224|Proteobacteria,2TTB1@28211|Alphaproteobacteria 28211|Alphaproteobacteria I 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III - - - - - - - - - - - - ACP_syn_III_C,OB_aCoA_assoc k59_511920_2 247634.GPB2148_2980 5.91e-24 94.7 COG1950@1|root,COG1950@2|Bacteria 2|Bacteria S Mycobacterial 4 TMS phage holin, superfamily IV yvlD - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 k59_923696_1 1469245.JFBG01000091_gene1645 2.07e-76 238.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1WXNB@135613|Chromatiales 135613|Chromatiales BQ PFAM Histone deacetylase - - - - - - - - - - - - Hist_deacetyl k59_348774_1 1123399.AQVE01000017_gene3702 8.11e-46 160.0 COG3509@1|root,COG3509@2|Bacteria,1NTIV@1224|Proteobacteria,1RZ9J@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Esterase PHB depolymerase - - - - - - - - - - - - Esterase,Esterase_phd k59_348774_2 1123514.KB905899_gene1735 2.06e-17 75.9 2EFT3@1|root,339J3@2|Bacteria,1NH28@1224|Proteobacteria,1SI3W@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_348774_3 329726.AM1_2826 1.27e-28 116.0 COG1266@1|root,COG1266@2|Bacteria 2|Bacteria V CAAX protease self-immunity yprA - 3.4.11.19 ko:K01266,ko:K07052 - - - - ko00000,ko01000,ko01002 - - - Abi k59_454578_1 314287.GB2207_07761 1.77e-49 171.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,1J4Z3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon birA GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k59_399652_1 483219.LILAB_32750 1.31e-09 63.9 COG0484@1|root,COG0484@2|Bacteria,1QXUZ@1224|Proteobacteria,43C7N@68525|delta/epsilon subdivisions,2X7HY@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Domain of unknown function (DUF4388) - - - - - - - - - - - - DUF4388 k59_95306_1 331869.BAL199_04969 7.78e-06 46.6 COG0789@1|root,COG0789@2|Bacteria,1MZ3P@1224|Proteobacteria,2UC95@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator merR - - ko:K08365 - - - - ko00000,ko03000 - - - MerR,MerR-DNA-bind,MerR_1 k59_95306_2 93220.LV28_01955 1.67e-25 104.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VMYW@28216|Betaproteobacteria,1K1RG@119060|Burkholderiaceae 28216|Betaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_348784_1 1284708.HMPREF1634_04415 3.27e-19 89.7 COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,3WD3D@538999|Clostridiales incertae sedis 186801|Clostridia D 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1658653_1 335543.Sfum_3971 8.03e-80 251.0 COG2308@1|root,COG2308@2|Bacteria,1NG4H@1224|Proteobacteria,42WK0@68525|delta/epsilon subdivisions,2WS0X@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - k59_1448276_1 1286106.MPL1_07089 1.26e-23 94.7 COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,460D7@72273|Thiotrichales 72273|Thiotrichales L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 k59_1448276_2 396588.Tgr7_1079 9.08e-17 76.3 COG2010@1|root,COG2010@2|Bacteria,1N71Z@1224|Proteobacteria,1SF76@1236|Gammaproteobacteria,1WZJF@135613|Chromatiales 135613|Chromatiales C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 k59_348791_1 314278.NB231_05816 1.31e-09 59.7 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1WW30@135613|Chromatiales 135613|Chromatiales S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - ko:K11206 - - - - ko00000,ko01000 - - - CN_hydrolase k59_348791_2 1005058.UMN179_01336 2.19e-06 50.1 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria,1Y7CC@135625|Pasteurellales 135625|Pasteurellales IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_296653_1 1247649.D560_0394 1.14e-20 90.9 COG3639@1|root,COG3639@2|Bacteria,1MUD6@1224|Proteobacteria,2VNB0@28216|Betaproteobacteria,3T3ZQ@506|Alcaligenaceae 28216|Betaproteobacteria P ABC-type phosphate phosphonate transport system permease component phnE_1 - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 k59_296653_2 653733.Selin_2166 8.04e-29 112.0 COG3639@1|root,COG3639@2|Bacteria 2|Bacteria P organic phosphonate transmembrane transporter activity phnE - 3.6.1.63 ko:K02042,ko:K06162 ko00440,ko02010,map00440,map02010 M00223 R10186 RC00002 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.9 - - BPD_transp_1 k59_241804_1 237368.SCABRO_03232 5.32e-46 159.0 COG4798@1|root,COG4798@2|Bacteria,2IYU0@203682|Planctomycetes 203682|Planctomycetes S COG2226 Methylase involved in ubiquinone menaquinone - - - - - - - - - - - - Methyltransf_11 k59_184638_1 330214.NIDE1417 1.08e-32 121.0 COG1354@1|root,COG1354@2|Bacteria,3J13J@40117|Nitrospirae 40117|Nitrospirae D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_923759_1 500632.CLONEX_00384 1.22e-21 90.5 COG0231@1|root,COG0231@2|Bacteria,1TR8P@1239|Firmicutes,249DV@186801|Clostridia 186801|Clostridia J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_95351_1 314264.ROS217_01860 1.47e-32 119.0 COG0831@1|root,COG0832@1|root,COG0831@2|Bacteria,COG0832@2|Bacteria,1RGXE@1224|Proteobacteria,2U0RZ@28211|Alphaproteobacteria,46QX8@74030|Roseovarius 28211|Alphaproteobacteria E Belongs to the urease gamma subunit family - - 3.5.1.5 ko:K14048 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Urease_beta,Urease_gamma k59_95351_2 1116472.MGMO_118c00190 3.69e-07 52.0 COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,1RMEM@1236|Gammaproteobacteria,1XE0E@135618|Methylococcales 135618|Methylococcales E ABC transporter - - - ko:K11963 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran k59_1024857_1 1229909.NSED_00410 4.28e-42 142.0 arCOG08825@1|root,arCOG08825@2157|Archaea,41T4G@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1024857_2 436308.Nmar_0186 1.51e-63 197.0 COG0109@1|root,arCOG03103@2157|Archaea,41SNT@651137|Thaumarchaeota 651137|Thaumarchaeota O Cytochrome oxidase assembly protein - - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_1024857_3 1229909.NSED_00400 3.75e-16 76.3 COG2132@1|root,arCOG03914@2157|Archaea,41T22@651137|Thaumarchaeota 651137|Thaumarchaeota Q Multicopper oxidase - - 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Copper-bind k59_241824_1 309801.trd_0262 2.59e-34 133.0 COG0247@1|root,COG0247@2|Bacteria,2G5V8@200795|Chloroflexi,27XTC@189775|Thermomicrobia 189775|Thermomicrobia C Cysteine-rich domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_8 k59_1334282_1 489825.LYNGBM3L_63180 5.88e-93 295.0 COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria,1H9BF@1150|Oscillatoriales 1117|Cyanobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1297791_1 316058.RPB_3211 6.5e-47 172.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TQMV@28211|Alphaproteobacteria,3JSPM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G PQQ-like domain gcd - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 k59_1389717_1 935840.JAEQ01000011_gene1814 4.85e-119 350.0 COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,2TSXQ@28211|Alphaproteobacteria,43I2S@69277|Phyllobacteriaceae 28211|Alphaproteobacteria F Inosine-uridine preferring nucleoside hydrolase rihA GO:0003674,GO:0003824,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008655,GO:0009056,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009164,GO:0009165,GO:0009435,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019357,GO:0019358,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0034356,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0043094,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0045437,GO:0046135,GO:0046483,GO:0046496,GO:0046497,GO:0046700,GO:0050263,GO:0051186,GO:0051188,GO:0055086,GO:0070635,GO:0070636,GO:0071704,GO:0072521,GO:0072523,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.2.2.1 ko:K01239 ko00230,ko00760,ko01100,map00230,map00760,map01100 - R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 - - - IU_nuc_hydro k59_1448307_1 570952.ATVH01000014_gene1908 4.37e-05 47.0 COG0730@1|root,COG0730@2|Bacteria,1MWAN@1224|Proteobacteria,2TS4X@28211|Alphaproteobacteria,2JSQQ@204441|Rhodospirillales 204441|Rhodospirillales S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_1448307_2 258594.RPA1011 3.06e-44 150.0 COG3917@1|root,COG3917@2|Bacteria,1MV6E@1224|Proteobacteria,2TVJ4@28211|Alphaproteobacteria,3JRC6@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q DSBA-like thioredoxin domain MA20_23730 - - - - - - - - - - - DSBA k59_348831_1 1173028.ANKO01000009_gene1747 2.76e-36 139.0 COG2199@1|root,COG2202@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,1FZWU@1117|Cyanobacteria 1117|Cyanobacteria T Diguanylate cyclase with PAS PAC and GAF sensors - - - - - - - - - - - - CHASE3,GAF,GAF_2,GAF_3,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_95366_1 436308.Nmar_1273 3.3e-24 102.0 COG3794@1|root,arCOG02926@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind k59_1453879_1 1121434.AULY01000007_gene1026 6.43e-60 201.0 COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,42Q1H@68525|delta/epsilon subdivisions,2WK7W@28221|Deltaproteobacteria,2M8T3@213115|Desulfovibrionales 28221|Deltaproteobacteria G pfam mofrl Glyctk - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_720515_1 1055815.AYYA01000055_gene952 1.43e-11 72.0 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,3NII0@468|Moraxellaceae 1236|Gammaproteobacteria T Signal transducing histidine kinase, homodimeric domain chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1545900_1 1125863.JAFN01000001_gene1535 3.03e-79 253.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42MZZ@68525|delta/epsilon subdivisions,2WIQI@28221|Deltaproteobacteria 28221|Deltaproteobacteria H MoeA domain protein domain I and II moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_769909_1 338963.Pcar_3003 6.81e-43 160.0 COG1538@1|root,COG1538@2|Bacteria,1MYXE@1224|Proteobacteria,42TA7@68525|delta/epsilon subdivisions,2WR7T@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1668037_1 330214.NIDE0563 1.75e-115 345.0 COG1032@1|root,COG1032@2|Bacteria,3J0WM@40117|Nitrospirae 40117|Nitrospirae C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_1339901_1 395964.KE386496_gene1402 1.01e-24 98.6 COG3686@1|root,COG3686@2|Bacteria,1N00R@1224|Proteobacteria,2U94Y@28211|Alphaproteobacteria,3NCQ3@45404|Beijerinckiaceae 28211|Alphaproteobacteria S MAPEG family - - - - - - - - - - - - MAPEG k59_406140_1 1299327.I546_6563 3.17e-58 188.0 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator - - - - - - - - - - - - DUF1956,TetR_N k59_1183674_1 330214.NIDE3966 6.61e-184 526.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cvaA - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,OEP k59_561395_1 1278073.MYSTI_02361 1.73e-106 327.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2WIXI@28221|Deltaproteobacteria,2YUJG@29|Myxococcales 28221|Deltaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_460913_1 472759.Nhal_1115 1.09e-218 634.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales 135613|Chromatiales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_406163_1 304371.MCP_0949 1.13e-18 90.1 COG1004@1|root,COG1215@1|root,arCOG00253@2157|Archaea,arCOG01389@2157|Archaea,2Y2BI@28890|Euryarchaeota,2NAA2@224756|Methanomicrobia 224756|Methanomicrobia M glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2,UDPG_MGDP_dh,UDPG_MGDP_dh_N k59_1545934_1 318167.Sfri_2292 1.31e-30 113.0 COG1814@1|root,COG1814@2|Bacteria,1RBQN@1224|Proteobacteria,1S2ZU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S membrane - - - - - - - - - - - - - k59_1545934_2 314345.SPV1_09583 5.29e-54 190.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria 1224|Proteobacteria P ATPase, P-type transporting, HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_1395284_1 1463820.JOGW01000004_gene4552 3.66e-22 95.9 COG2141@1|root,COG2141@2|Bacteria,2IB78@201174|Actinobacteria 201174|Actinobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_1395286_1 330214.NIDE1146 7.53e-34 128.0 COG1249@1|root,COG1249@2|Bacteria,3J0IM@40117|Nitrospirae 40117|Nitrospirae C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_1395286_2 330214.NIDE1147 3.11e-99 295.0 292MF@1|root,2ZQ5C@2|Bacteria 2|Bacteria S Protein of unknown function (DUF3047) - - - - - - - - - - - - DUF3047 k59_1668097_1 436308.Nmar_0015 1.46e-16 74.7 COG0239@1|root,arCOG04701@2157|Archaea,41T4U@651137|Thaumarchaeota 651137|Thaumarchaeota U Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB k59_1668097_2 1229909.NSED_09710 1.14e-26 98.6 COG5466@1|root,arCOG05278@2157|Archaea 2157|Archaea S small metal-binding protein - - - - - - - - - - - - DUF1059 k59_1668102_1 1417296.U879_20410 2.04e-05 50.1 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases MA20_25935 - 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1668102_2 266117.Rxyl_2877 1.46e-13 69.3 COG1246@1|root,COG1246@2|Bacteria 2|Bacteria E Belongs to the acetyltransferase family. ArgA subfamily ywlB - 2.3.1.1 ko:K00619 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7,C_GCAxxG_C_C k59_1183704_1 1038859.AXAU01000028_gene27 1.92e-55 179.0 COG0410@1|root,COG0410@2|Bacteria,1R6QK@1224|Proteobacteria,2U82Z@28211|Alphaproteobacteria,3JZBP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_1183704_2 1038859.AXAU01000028_gene25 2.06e-75 241.0 COG4177@1|root,COG4177@2|Bacteria,1N5I8@1224|Proteobacteria,2U0PT@28211|Alphaproteobacteria,3JSC7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_460949_1 641491.DND132_0692 1.54e-20 88.2 2DMKI@1|root,32S70@2|Bacteria,1N1FV@1224|Proteobacteria,42VW0@68525|delta/epsilon subdivisions 1224|Proteobacteria S SpoIIAA-like VVA0543 - - - - - - - - - - - SpoIIAA-like k59_875112_1 1110697.NCAST_15_00005 4.56e-06 50.1 COG3415@1|root,COG3415@2|Bacteria 2|Bacteria L Transposase - - - - - - - - - - - - HTH_23,HTH_28,LZ_Tnp_IS481 k59_303629_2 436308.Nmar_1653 7.26e-71 220.0 COG1108@1|root,arCOG01006@2157|Archaea,41SG2@651137|Thaumarchaeota 651137|Thaumarchaeota P ABC 3 transport family - - - ko:K09816 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_1604124_1 640511.BC1002_2248 7.69e-35 133.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,1JZNE@119060|Burkholderiaceae 28216|Betaproteobacteria C Formate dehydrogenase alpha subunit fdsA - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1604124_2 1123228.AUIH01000013_gene169 1.49e-34 130.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1XH7K@135619|Oceanospirillales 135619|Oceanospirillales C NADH-quinone oxidoreductase subunit F fdsB - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Complex1_51K,NADH_4Fe-4S,SLBB k59_1453938_1 71139.XP_010066017.1 2.12e-09 58.5 COG0693@1|root,KOG2764@2759|Eukaryota,37JAT@33090|Viridiplantae,3G8PR@35493|Streptophyta 35493|Streptophyta V Protein DJ-1 homolog C - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006996,GO:0008150,GO:0009507,GO:0009536,GO:0009657,GO:0009658,GO:0009987,GO:0016043,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0071840 3.5.1.124 ko:K03152 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_1453938_2 637910.ROD_42021 1.86e-10 64.3 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,1RNKH@1236|Gammaproteobacteria,3WWUD@544|Citrobacter 1236|Gammaproteobacteria S Divergent polysaccharide deacetylase yibQ - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_1139046_1 1499967.BAYZ01000078_gene970 1.75e-20 97.1 COG0557@1|root,COG0557@2|Bacteria,2NNV2@2323|unclassified Bacteria 2|Bacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_102253_1 517417.Cpar_1721 4.78e-11 68.6 COG2177@1|root,COG2177@2|Bacteria,1FDVX@1090|Chlorobi 1090|Chlorobi D Belongs to the ABC-4 integral membrane protein family. FtsX subfamily - - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - - k59_521322_1 502025.Hoch_6809 2.56e-14 73.6 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria,2YUIX@29|Myxococcales 28221|Deltaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_521322_2 498761.HM1_1354 2.31e-45 161.0 COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia 186801|Clostridia I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB k59_1453958_1 1122185.N792_11820 5.12e-09 63.5 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1X36C@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the peptidase S41A family ctp - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_1246872_1 1318628.MARLIPOL_07114 2.36e-124 369.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,4658N@72275|Alteromonadaceae 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0031224,GO:0031226,GO:0034641,GO:0036094,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - iEcE24377_1341.EcE24377A_1810 AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_147641_1 502025.Hoch_3422 3.52e-11 68.6 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2WIQ7@28221|Deltaproteobacteria,2YTZJ@29|Myxococcales 28221|Deltaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1339971_1 1536769.P40081_25115 6.84e-24 99.0 COG3153@1|root,COG3153@2|Bacteria,1V3PW@1239|Firmicutes,4HGZK@91061|Bacilli,26XET@186822|Paenibacillaceae 91061|Bacilli S GCN5 family acetyltransferase - - - ko:K03824 - - - - ko00000,ko01000 - - - Acetyltransf_1,Acetyltransf_7,Acetyltransf_9 k59_1668162_1 1087448.Eab7_0755 2.41e-08 61.6 COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,4H9KA@91061|Bacilli,3WE5G@539002|Bacillales incertae sedis 91061|Bacilli O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_460985_1 1235788.C802_03026 2.76e-23 104.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FKYX@200643|Bacteroidia,4AK5Y@815|Bacteroidaceae 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1087121_1 247490.KSU1_B0329 4.64e-83 254.0 COG0226@1|root,COG0226@2|Bacteria,2IYX0@203682|Planctomycetes 203682|Planctomycetes P COG0226 ABC-type phosphate transport system periplasmic - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like,PBP_like_2 k59_1087121_2 1397528.Q671_08845 0.000253 44.7 COG4590@1|root,COG4590@2|Bacteria,1QTTD@1224|Proteobacteria,1T1GK@1236|Gammaproteobacteria,1XHZ0@135619|Oceanospirillales 135619|Oceanospirillales P ABC transporter permease pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_613187_1 1229909.NSED_01250 3.94e-149 428.0 COG0470@1|root,arCOG00470@2157|Archaea,41S9F@651137|Thaumarchaeota 651137|Thaumarchaeota L ATPase family associated with various cellular activities (AAA) - - - ko:K04800 ko03030,map03030 - - - ko00000,ko00001,ko03032 - - - AAA k59_1604149_1 324925.Ppha_0446 1.94e-07 56.6 COG0457@1|root,COG0457@2|Bacteria,1FD7Y@1090|Chlorobi 1090|Chlorobi K PFAM TPR repeat-containing protein - - - - - - - - - - - - TPR_12,TPR_7,TPR_8 k59_18827_1 945713.IALB_0962 7.21e-13 67.0 COG3536@1|root,COG3536@2|Bacteria 2|Bacteria S Protein of unknown function (DUF971) - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - DUF971 k59_561484_1 323850.Shew_1230 3.59e-11 60.8 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria,2QA3I@267890|Shewanellaceae 1236|Gammaproteobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_561484_2 765912.Thimo_0189 2.35e-111 333.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1WW3A@135613|Chromatiales 135613|Chromatiales F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_303681_1 555217.Zmob_1148 0.000178 46.2 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 MA20_08330 - - - - - - - - - - - - k59_303681_3 445686.E3SLF3_9CAUD 1.8e-23 100.0 4QEWA@10239|Viruses,4QVNR@35237|dsDNA viruses no RNA stage,4QU9E@28883|Caudovirales,4QINZ@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_461002_1 105559.Nwat_2043 4.44e-18 88.2 COG0412@1|root,COG0412@2|Bacteria,1QW3K@1224|Proteobacteria,1S38F@1236|Gammaproteobacteria,1X0ND@135613|Chromatiales 135613|Chromatiales Q Alpha/beta hydrolase family - - - - - - - - - - - - - k59_1339986_1 1382356.JQMP01000003_gene1584 2.01e-19 91.3 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi,27XKK@189775|Thermomicrobia 189775|Thermomicrobia C Succinyl-CoA ligase like flavodoxin domain - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_1339986_2 318424.EU78_02930 1.76e-14 75.9 COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,2341G@1762|Mycobacteriaceae 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1546025_1 1131269.AQVV01000070_gene1534 4.56e-32 126.0 COG0592@1|root,COG0592@2|Bacteria 2|Bacteria L DNA-directed DNA polymerase activity dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_1546028_1 330214.NIDE4374 8.82e-66 210.0 COG1091@1|root,COG1091@2|Bacteria 2|Bacteria M dTDP-4-dehydrorhamnose reductase activity rmlD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_521379_1 1415780.JPOG01000001_gene2508 1.13e-51 184.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria,1SMN0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_249642_1 398767.Glov_1376 8.19e-33 132.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria 28221|Deltaproteobacteria T histidine kinase HAMP region domain protein ntrY - 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_721743_1 1499967.BAYZ01000081_gene1046 5.46e-27 106.0 COG1280@1|root,COG1280@2|Bacteria,2NR6Y@2323|unclassified Bacteria 2|Bacteria E LysE type translocator - - - - - - - - - - - - LysE k59_1088300_1 330214.NIDE1029 2.03e-68 219.0 COG1477@1|root,COG1477@2|Bacteria 2|Bacteria H protein flavinylation nosX - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_1547274_1 272562.CA_C3055 2.95e-67 217.0 COG2605@1|root,COG2605@2|Bacteria,1V0XM@1239|Firmicutes,25D2P@186801|Clostridia,36U63@31979|Clostridiaceae 186801|Clostridia S GHMP kinases C terminal - - 2.7.1.168 ko:K07031 ko00540,map00540 - R09770 RC00002,RC00078 ko00000,ko00001,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_562569_1 1454004.AW11_03604 3.17e-17 85.5 COG2165@1|root,COG2165@2|Bacteria,1RHE1@1224|Proteobacteria,2VSJ6@28216|Betaproteobacteria 28216|Betaproteobacteria NU general secretion pathway protein - - - - - - - - - - - - N_methyl k59_1340991_1 1121440.AUMA01000006_gene1447 5.28e-184 540.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2WJ2W@28221|Deltaproteobacteria,2M92I@213115|Desulfovibrionales 28221|Deltaproteobacteria O ATP-dependent Clp protease ATP-binding subunit ClpA clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1247903_1 1117647.M5M_04610 4.66e-35 129.0 COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria,1J4YC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U COG0811 Biopolymer transport proteins - - - - - - - - - - - - MotA_ExbB k59_1088313_1 330214.NIDE3334 2.06e-82 252.0 COG3751@1|root,COG3751@2|Bacteria 2|Bacteria O 2OG-Fe(II) oxygenase superfamily - - - ko:K07394 - - - - ko00000 - - - 2OG-FeII_Oxy_3,2OG-FeII_Oxy_4 k59_407520_1 583355.Caka_2912 7.91e-82 257.0 COG3303@1|root,COG3303@2|Bacteria,46UP1@74201|Verrucomicrobia,3K7Z3@414999|Opitutae 414999|Opitutae C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_C552 k59_407523_1 926561.KB900619_gene2568 2.12e-52 173.0 COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,3WA6N@53433|Halanaerobiales 186801|Clostridia J TIGRFAM methionine aminopeptidase, type I map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_407523_2 717231.Flexsi_0486 2.01e-28 103.0 COG0361@1|root,COG0361@2|Bacteria,2GFTE@200930|Deferribacteres 200930|Deferribacteres J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_249666_1 644801.Psest_3546 9.39e-08 53.5 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1Z20B@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) pgpA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - iECSP_1301.ECSP_0485,iECUMN_1333.ECUMN_0456,iECs_1301.ECs0471,iG2583_1286.G2583_0529,iPC815.YPO3179,iZ_1308.Z0520 PgpA k59_249666_2 519989.ECTPHS_05836 2.04e-54 183.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1WW48@135613|Chromatiales 135613|Chromatiales H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1032777_1 395493.BegalDRAFT_1605 9.02e-44 150.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,45ZN2@72273|Thiotrichales 72273|Thiotrichales Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_876289_1 1229909.NSED_05220 5.58e-75 234.0 COG0367@1|root,arCOG00071@2157|Archaea,41SMA@651137|Thaumarchaeota 651137|Thaumarchaeota E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase k59_1140544_1 706587.Desti_1872 2.08e-25 100.0 COG3448@1|root,COG3448@2|Bacteria,1Q1A8@1224|Proteobacteria,42SIQ@68525|delta/epsilon subdivisions,2WPF0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM CBS domain - - - - - - - - - - - - CBS k59_721774_1 768671.ThimaDRAFT_4172 8.87e-121 354.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,1T0C6@1236|Gammaproteobacteria,1WXH4@135613|Chromatiales 135613|Chromatiales C PFAM Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_1140558_1 330214.NIDE1331 5.2e-100 301.0 COG0201@1|root,COG0201@2|Bacteria,3J0C0@40117|Nitrospirae 40117|Nitrospirae U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_1140558_2 403833.Pmob_0769 4.41e-10 58.9 COG0563@1|root,COG0563@2|Bacteria,2GCW0@200918|Thermotogae 200918|Thermotogae F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_356904_2 316067.Geob_3107 2.14e-37 137.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,42M7V@68525|delta/epsilon subdivisions,2WIUB@28221|Deltaproteobacteria,43U4M@69541|Desulfuromonadales 28221|Deltaproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_562613_1 443143.GM18_3943 7.43e-90 284.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,42MZ4@68525|delta/epsilon subdivisions,2WJPB@28221|Deltaproteobacteria,43T5J@69541|Desulfuromonadales 28221|Deltaproteobacteria H Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_1032805_1 545264.KB898750_gene333 2.53e-45 155.0 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1WY2F@135613|Chromatiales 135613|Chromatiales O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_570739_1 187303.BN69_1147 5.44e-70 235.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria,36XVQ@31993|Methylocystaceae 28211|Alphaproteobacteria G PEP-utilising enzyme, mobile domain ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_203326_1 1524467.IV04_16030 1.13e-20 88.6 COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,1TAPS@1236|Gammaproteobacteria,4037X@613|Serratia 1236|Gammaproteobacteria S Domain of unknown function (DUF1993) - - - - - - - - - - - - DUF1993 k59_1351163_1 1444711.CCJF01000005_gene302 2.23e-20 88.6 COG1392@1|root,COG1392@2|Bacteria,2JFZT@204428|Chlamydiae 204428|Chlamydiae P Protein of unknown function DUF47 CP_0066 - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_1351163_2 338966.Ppro_0522 1.51e-09 55.8 COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,42URG@68525|delta/epsilon subdivisions,2WNDG@28221|Deltaproteobacteria,43URU@69541|Desulfuromonadales 28221|Deltaproteobacteria E Glyoxalase-like domain mceE - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 k59_1040610_1 997829.HMPREF1121_01757 4.41e-10 65.1 COG1752@1|root,COG1752@2|Bacteria,4NERH@976|Bacteroidetes,2FNX7@200643|Bacteroidia,22XKQ@171551|Porphyromonadaceae 976|Bacteroidetes S Phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_625464_1 321955.AAGP01000005_gene15 1.95e-17 87.0 COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria,4FAVJ@85019|Brevibacteriaceae 201174|Actinobacteria C FAD linked oxidases, C-terminal domain eapA - 2.5.1.26 ko:K00803 ko00565,ko01100,ko04146,map00565,map01100,map04146 - R04311 RC00020,RC02886 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_23350_1 1453505.JASY01000006_gene1240 5.05e-13 75.5 COG3254@1|root,COG3420@1|root,COG3254@2|Bacteria,COG3420@2|Bacteria,4NF5Y@976|Bacteroidetes,1I4UI@117743|Flavobacteriia,2NV2S@237|Flavobacterium 976|Bacteroidetes P L-rhamnose mutarotase - - - - - - - - - - - - Beta_helix,rhaM k59_1406505_2 330214.NIDE3365 4.88e-78 253.0 COG0683@1|root,COG0683@2|Bacteria,3J18U@40117|Nitrospirae 40117|Nitrospirae E Periplasmic binding protein - - - - - - - - - - - - Peripla_BP_6 k59_989116_1 857087.Metme_1947 9.95e-18 80.9 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,1S400@1236|Gammaproteobacteria,1XF3U@135618|Methylococcales 135618|Methylococcales S PFAM Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_989116_2 43989.cce_2226 2.5e-37 128.0 COG2154@1|root,COG2154@2|Bacteria,1G6T6@1117|Cyanobacteria,3KI7J@43988|Cyanothece 1117|Cyanobacteria H PFAM transcriptional coactivator pterin dehydratase - - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a k59_1612200_1 2340.JV46_07080 1.8e-65 216.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1J4ZC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_1351250_2 331869.BAL199_30057 1.81e-06 49.3 COG3608@1|root,COG3608@2|Bacteria,1MV55@1224|Proteobacteria,2U00P@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Succinylglutamate desuccinylase / Aspartoacylase family - - - - - - - - - - - - AstE_AspA k59_570854_1 414684.RC1_0800 3.64e-105 322.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,2TU50@28211|Alphaproteobacteria,2JSBB@204441|Rhodospirillales 204441|Rhodospirillales U MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_729902_1 1038859.AXAU01000028_gene30 1.21e-57 201.0 COG0348@1|root,COG3889@1|root,COG0348@2|Bacteria,COG3889@2|Bacteria,1R9JQ@1224|Proteobacteria,2U3WR@28211|Alphaproteobacteria,3K36U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C domain, Protein - - - - - - - - - - - - - k59_203525_1 349521.HCH_04249 3.22e-50 175.0 COG3517@1|root,COG3517@2|Bacteria,1MU5C@1224|Proteobacteria,1RNP7@1236|Gammaproteobacteria,1XN9P@135619|Oceanospirillales 135619|Oceanospirillales S Type VI secretion protein, EvpB/VC_A0108, tail sheath - - - ko:K11899 - - - - ko00000,ko02044 - - - VipB k59_1351296_1 488538.SAR116_0889 9.73e-48 165.0 COG3839@1|root,COG3839@2|Bacteria,1MX8G@1224|Proteobacteria,2TSXF@28211|Alphaproteobacteria,4BP6W@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G ABC transporter glpS - - ko:K17324 ko02010,map02010 M00607 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.35 - - ABC_tran,TOBE_2 k59_989230_1 1328313.DS2_11478 4.75e-105 314.0 COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,1RPTN@1236|Gammaproteobacteria,4647V@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - 2.4.1.266 ko:K13693 - - - - ko00000,ko01000,ko01003 - GT81 - - k59_257886_1 1123400.KB904817_gene1460 1.21e-105 325.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,46061@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_729932_1 1122604.JONR01000026_gene2951 2.39e-76 255.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1X3MQ@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_778931_1 649639.Bcell_3756 1.06e-93 285.0 COG0667@1|root,COG0667@2|Bacteria,1TRS0@1239|Firmicutes,4HBX5@91061|Bacilli,1ZB9B@1386|Bacillus 91061|Bacilli C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_778931_2 317619.ANKN01000068_gene3589 1.16e-05 46.6 COG4445@1|root,COG4445@2|Bacteria,1G1MM@1117|Cyanobacteria,1MKNN@1212|Prochloraceae 1117|Cyanobacteria FJ Alternative locus ID miaE - - ko:K06169 - - - - ko00000,ko01000,ko03016 - - - MiaE k59_24148_2 398527.Bphyt_2668 4.01e-47 164.0 COG5429@1|root,COG5429@2|Bacteria,1MW6R@1224|Proteobacteria,2VSC6@28216|Betaproteobacteria,1K582@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1223) - - - - - - - - - - - - DUF1223 k59_572785_1 290397.Adeh_4214 1.7e-129 391.0 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2WITS@28221|Deltaproteobacteria,2YUCV@29|Myxococcales 28221|Deltaproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,PurS k59_1560917_1 519989.ECTPHS_00390 3.78e-65 216.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1WWKZ@135613|Chromatiales 135613|Chromatiales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_572793_1 1254432.SCE1572_30505 2.28e-50 171.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,42PQH@68525|delta/epsilon subdivisions,2WM5W@28221|Deltaproteobacteria,2Z39N@29|Myxococcales 28221|Deltaproteobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_992135_1 686578.AFFX01000010_gene2269 2.77e-68 214.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the UPF0758 family radC GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - ko:K03630 - - - - ko00000 - - - RadC k59_1197250_1 643562.Daes_0041 1.33e-36 139.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42MAP@68525|delta/epsilon subdivisions,2X85M@28221|Deltaproteobacteria,2M8ZC@213115|Desulfovibrionales 28221|Deltaproteobacteria P Sodium:sulfate symporter transmembrane region - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_885878_1 298654.FraEuI1c_5558 1.72e-24 103.0 COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria 201174|Actinobacteria S Pfam Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_885878_2 13690.CP98_03777 1.09e-19 88.2 COG2030@1|root,COG2030@2|Bacteria,1NTV7@1224|Proteobacteria,2UQFU@28211|Alphaproteobacteria,2K8I3@204457|Sphingomonadales 204457|Sphingomonadales I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydrat_N k59_780697_1 911045.PSE_0437 1.01e-116 349.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQQH@28211|Alphaproteobacteria 28211|Alphaproteobacteria E ABC-type dipeptide transport system periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_992202_2 224324.aq_199 1.53e-36 138.0 COG1503@1|root,COG1503@2|Bacteria 2|Bacteria J translation release factor activity yocB GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0016020,GO:0030312,GO:0036293,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944 - ko:K03265 ko03015,map03015 - - - ko00000,ko00001,ko03012,ko03019 - - - - k59_992209_2 717785.HYPMC_0346 2.09e-24 103.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2TRHK@28211|Alphaproteobacteria,3N62R@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2 k59_1561033_1 1499967.BAYZ01000184_gene4591 2.72e-95 291.0 COG0638@1|root,COG0638@2|Bacteria,2NQFW@2323|unclassified Bacteria 2|Bacteria O Pup-ligase protein pafA GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 ko:K13571 - M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 - - - Pup_ligase k59_885927_1 713586.KB900536_gene1938 5.18e-16 78.6 COG1413@1|root,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity - - - - - - - - - - - - HEAT_2,NB-ARC,cNMP_binding k59_1197332_1 337075.U4LBQ6 1.27e-45 158.0 COG0388@1|root,KOG0807@2759|Eukaryota,38BM9@33154|Opisthokonta,3NW7Z@4751|Fungi,3QJKF@4890|Ascomycota 4751|Fungi E nitrilase NIT2 GO:0003674,GO:0003824,GO:0004551,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015962,GO:0015964,GO:0016462,GO:0016787,GO:0016810,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0047710,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.5.1.6 ko:K01431,ko:K11206 ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100 M00046 R00905,R04666,R08228 RC00096 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase k59_992241_1 1317124.DW2_08622 2.44e-81 267.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,2TR2N@28211|Alphaproteobacteria,2XP1Q@285107|Thioclava 28211|Alphaproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_206549_1 243233.MCA0970 5.01e-11 65.1 COG0524@1|root,COG0524@2|Bacteria,1MWX4@1224|Proteobacteria,1RU49@1236|Gammaproteobacteria,1XETS@135618|Methylococcales 135618|Methylococcales G Belongs to the carbohydrate kinase PfkB family - - - - - - - - - - - - PfkB k59_992264_1 477974.Daud_1920 3.65e-116 352.0 COG1322@1|root,COG1322@2|Bacteria,1TPWI@1239|Firmicutes,24CA4@186801|Clostridia,260IP@186807|Peptococcaceae 186801|Clostridia S RmuC family rmuC - - ko:K09760 - - - - ko00000 - - - RmuC k59_1613659_1 416591.Tlet_0492 1.47e-12 67.0 COG1515@1|root,COG1515@2|Bacteria,2GCUF@200918|Thermotogae 200918|Thermotogae L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA nfi - 3.1.21.7 ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 k59_1613659_2 1230476.C207_02108 4.41e-25 105.0 COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,3JRVJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - POR_N,TPP_enzyme_C k59_206569_1 519989.ECTPHS_10666 7.48e-84 261.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1WW0V@135613|Chromatiales 135613|Chromatiales M lipoprotein releasing system, transmembrane protein, LolC E family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_1197380_1 323848.Nmul_A1268 3.79e-36 129.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2VZ53@28216|Betaproteobacteria,374MG@32003|Nitrosomonadales 28216|Betaproteobacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_780778_1 1110502.TMO_0855 1.18e-38 139.0 COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2TUQ1@28211|Alphaproteobacteria,2JPSS@204441|Rhodospirillales 204441|Rhodospirillales S Putative cyclase - - - - - - - - - - - - Cyclase k59_780778_2 1133849.O3I_007150 9.67e-17 78.6 COG1028@1|root,COG1028@2|Bacteria,2GIX2@201174|Actinobacteria,4FUS7@85025|Nocardiaceae 201174|Actinobacteria IQ 3-oxoacyl- acyl-carrier-protein reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_885980_1 378806.STAUR_4690 3.27e-179 516.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,42MMB@68525|delta/epsilon subdivisions,2WJBM@28221|Deltaproteobacteria,2YTUN@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_206615_1 331869.BAL199_12941 6.16e-82 255.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2VFEC@28211|Alphaproteobacteria,4BQWR@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_572956_1 243233.MCA0120 9.61e-07 51.6 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated - - - - - - - - - - - - AI-2E_transport k59_572956_2 1210884.HG799467_gene13274 8.32e-15 77.4 COG3659@1|root,COG3659@2|Bacteria,2IXZU@203682|Planctomycetes 203682|Planctomycetes M Belongs to the OprB family - - - ko:K07267 - - - - ko00000,ko02000 1.B.19.1 - - OprB k59_992341_1 1123504.JQKD01000098_gene2964 2.58e-66 218.0 COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VI39@28216|Betaproteobacteria,4AJ2P@80864|Comamonadaceae 28216|Betaproteobacteria EH Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_992349_1 1397666.RS24_00073 1.22e-42 158.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,4BPJW@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C acyl-CoA transferases carnitine dehydratase - - - - - - - - - - - - CoA_transf_3 k59_1353512_2 118161.KB235922_gene2796 3.88e-46 155.0 COG0545@1|root,COG0545@2|Bacteria,1G5T1@1117|Cyanobacteria,3VJJ8@52604|Pleurocapsales 1117|Cyanobacteria O PFAM FKBP-type peptidyl-prolyl cis-trans isomerase fkpA - 5.2.1.8 ko:K01802,ko:K03772 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_206646_1 684949.ATTJ01000001_gene1872 1.8e-17 83.2 COG0839@1|root,COG0839@2|Bacteria,1WKIC@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Belongs to the complex I subunit 6 family nuoJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_206646_2 992406.RIA_1530 3.64e-36 136.0 COG1005@1|root,COG1005@2|Bacteria,4NGK7@976|Bacteroidetes,1HY4Q@117743|Flavobacteriia 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_886006_1 314278.NB231_01289 4.44e-58 190.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1WXRN@135613|Chromatiales 135613|Chromatiales J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_886006_2 637390.AFOH01000046_gene2095 1.86e-12 65.5 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,2NCD7@225057|Acidithiobacillales 225057|Acidithiobacillales F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_992363_2 436308.Nmar_1777 2.22e-85 256.0 COG0846@1|root,arCOG04248@2157|Archaea,41SWP@651137|Thaumarchaeota 651137|Thaumarchaeota K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_992364_1 203122.Sde_3548 6.2e-21 99.0 COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,46408@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG0823 Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - PD40 k59_1353523_1 323261.Noc_2265 1.76e-25 109.0 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,1WXRZ@135613|Chromatiales 135613|Chromatiales M PFAM AsmA family protein - - - ko:K07289 - - - - ko00000 - - - AsmA k59_1408905_1 570967.JMLV01000006_gene275 1.15e-82 261.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VGSR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_1613699_1 472759.Nhal_2437 1.74e-195 556.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1WVXY@135613|Chromatiales 135613|Chromatiales J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_1100194_1 1166018.FAES_0685 3.16e-30 119.0 COG2220@1|root,COG2220@2|Bacteria,4NENZ@976|Bacteroidetes,47MND@768503|Cytophagia 976|Bacteroidetes S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_1100194_2 1033802.SSPSH_000482 3.78e-24 97.8 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,1RSP8@1236|Gammaproteobacteria 1236|Gammaproteobacteria T OST-HTH/LOTUS domain - - - - - - - - - - - - NYN,OST-HTH k59_56070_1 765912.Thimo_1444 1.31e-15 76.6 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1WWF7@135613|Chromatiales 135613|Chromatiales H TonB-dependent Receptor Plug - - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_577607_1 1122180.Lokhon_00643 1.75e-122 361.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2P8GI@245186|Loktanella 28211|Alphaproteobacteria G TRAP-type C4-dicarboxylate transport system - - - - - - - - - - - - DctM k59_787325_1 1392838.AWNM01000018_gene3433 2.35e-47 166.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2VHK9@28216|Betaproteobacteria,3T22S@506|Alcaligenaceae 28216|Betaproteobacteria H Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_264368_1 1229909.NSED_00115 2.74e-58 190.0 COG0702@1|root,arCOG03015@2157|Archaea,41T19@651137|Thaumarchaeota 651137|Thaumarchaeota M NAD(P)H-binding - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - NAD_binding_10 k59_525436_1 314278.NB231_09623 7e-99 301.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1T3U5@1236|Gammaproteobacteria,1X1MF@135613|Chromatiales 135613|Chromatiales M Putative transposase - - - - - - - - - - - - Y2_Tnp k59_1152062_1 519442.Huta_0024 4.91e-45 176.0 COG5013@1|root,arCOG01497@2157|Archaea,2XTNG@28890|Euryarchaeota,23TXI@183963|Halobacteria 183963|Halobacteria C Nitrate reductase alpha subunit narG - - ko:K17050 - - - - ko00000,ko02000 5.A.3.8 - - Molybdopterin,Molydop_binding k59_891303_1 62928.azo1888 8.71e-29 114.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VKJI@28216|Betaproteobacteria,2KVFT@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1569908_1 748280.NH8B_0112 2.07e-75 249.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2VJ54@28216|Betaproteobacteria 28216|Betaproteobacteria O Belongs to the peptidase S16 family - - - - - - - - - - - - AAA_32,Lon_C k59_943078_1 1121033.AUCF01000013_gene1600 2.12e-166 478.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRI1@28211|Alphaproteobacteria,2JQVU@204441|Rhodospirillales 204441|Rhodospirillales I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1308694_1 471853.Bcav_3232 8.35e-15 78.2 COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria 201174|Actinobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) menG GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044464,GO:0071944 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_368909_1 443598.AUFA01000005_gene3865 1.51e-36 136.0 COG2084@1|root,COG2084@2|Bacteria,1MX8V@1224|Proteobacteria,2TVBS@28211|Alphaproteobacteria,3JTCY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Domain of unknown function (DUF1932) MA20_26655 - - - - - - - - - - - DUF1932,NAD_binding_2 k59_1205265_1 436308.Nmar_1692 6.72e-89 265.0 COG1390@1|root,arCOG00869@2157|Archaea,41T4W@651137|Thaumarchaeota 651137|Thaumarchaeota C Produces ATP from ADP in the presence of a proton gradient across the membrane atpE - - ko:K02121 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_E k59_1100223_1 1122609.AUGT01000003_gene2247 1.53e-72 235.0 COG1960@1|root,COG1960@2|Bacteria,2GNBW@201174|Actinobacteria,4DNDM@85009|Propionibacteriales 201174|Actinobacteria I acyl-CoA dehydrogenase fadE23 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_1100227_1 1229909.NSED_06830 5.78e-48 168.0 COG4257@1|root,arCOG03564@2157|Archaea,41SM7@651137|Thaumarchaeota 651137|Thaumarchaeota V antibiotic catabolic process - - - ko:K18235 - - - - ko00000,ko01000,ko01504 - - - - k59_1100227_2 1042877.GQS_03510 2.28e-05 44.3 COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,24457@183968|Thermococci 183968|Thermococci J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K04794 - - - - ko00000,ko01000,ko03012 - - - PTH2 k59_943087_1 1458427.BAWN01000094_gene2212 2.33e-37 140.0 COG0399@1|root,COG4448@1|root,COG0399@2|Bacteria,COG4448@2|Bacteria,1MUMJ@1224|Proteobacteria,2VQRJ@28216|Betaproteobacteria 28216|Betaproteobacteria M Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_525455_1 153948.NAL212_0272 1.48e-71 226.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2VIR9@28216|Betaproteobacteria,3725N@32003|Nitrosomonadales 28216|Betaproteobacteria D cell shape determining protein, MreB Mrl mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_995248_2 3712.Bo1g016210.1 0.000112 50.1 COG0526@1|root,COG1524@1|root,KOG0907@2759|Eukaryota,KOG2645@2759|Eukaryota,37KCI@33090|Viridiplantae,3GAUW@35493|Streptophyta,3HQH0@3699|Brassicales 35493|Streptophyta L type I phosphodiesterase nucleotide pyrophosphatase - GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002276,GO:0002366,GO:0002376,GO:0002682,GO:0002683,GO:0002684,GO:0002694,GO:0002695,GO:0002697,GO:0002698,GO:0002699,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004528,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006955,GO:0008081,GO:0008150,GO:0008152,GO:0008270,GO:0008285,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009143,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0031347,GO:0031348,GO:0032101,GO:0032102,GO:0033003,GO:0033004,GO:0033006,GO:0033007,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036230,GO:0042127,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045321,GO:0045575,GO:0046034,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047429,GO:0048471,GO:0048518,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050727,GO:0050728,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0050865,GO:0050866,GO:0050896,GO:0055086,GO:0065007,GO:0070663,GO:0070664,GO:0070666,GO:0070667,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0080134,GO:0090304,GO:0090305,GO:0098552,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901575,GO:1901576 3.1.4.1,3.6.1.9 ko:K01513 ko00230,ko00240,ko00500,ko00740,ko00760,ko00770,ko01100,map00230,map00240,map00500,map00740,map00760,map00770,map01100 - R00056,R00087,R00103,R00160,R00287,R00515,R00662,R03004,R03036,R11323 RC00002 ko00000,ko00001,ko00537,ko01000,ko04090 - - - Phosphodiest k59_630734_1 1123508.JH636446_gene6165 1.26e-36 138.0 COG0304@1|root,COG0304@2|Bacteria,2IYQ8@203682|Planctomycetes 203682|Planctomycetes I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1308708_2 1121035.AUCH01000002_gene1673 2.13e-100 306.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,2KUWF@206389|Rhodocyclales 206389|Rhodocyclales O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_838970_1 76114.ebA3896 2.69e-10 64.3 COG1711@1|root,COG1711@2|Bacteria,1RIA0@1224|Proteobacteria,2VIHJ@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF3014) - - - - - - - - - - - - DUF3014 k59_682951_1 857087.Metme_3472 5.86e-104 311.0 COG0535@1|root,COG0535@2|Bacteria,1MXM1@1224|Proteobacteria,1RNQ1@1236|Gammaproteobacteria,1XEET@135618|Methylococcales 135618|Methylococcales S TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH - - - - - - - - - - - - DUF3463,Fer4_14,Radical_SAM k59_787380_1 78245.Xaut_2681 2.59e-31 119.0 COG2345@1|root,COG2345@2|Bacteria 2|Bacteria K Transcriptional regulator - - - - - - - - - - - - HTH_11,HTH_20,HTH_24,HTH_5,MarR_2 k59_682953_1 227377.CBU_1839 2.23e-53 181.0 COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,1RN24@1236|Gammaproteobacteria,1JG3H@118969|Legionellales 118969|Legionellales C FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_368936_2 243233.MCA2842 4.66e-44 160.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1XE9I@135618|Methylococcales 135618|Methylococcales S LysM domain - - - - - - - - - - - - LysM k59_316798_2 388919.SSA_0314 0.00021 46.6 COG0451@1|root,COG0451@2|Bacteria,1TRTD@1239|Firmicutes,4HFGT@91061|Bacilli,1WQGX@1305|Streptococcus sanguinis 91061|Bacilli GM Dihydrokaempferol 4-reductase wcaG - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase k59_995272_1 1163617.SCD_n02780 3e-61 203.0 COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,2VKQB@28216|Betaproteobacteria 28216|Betaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_682964_1 568706.BN118_1898 7.76e-40 135.0 COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,2VSJ2@28216|Betaproteobacteria,3T46T@506|Alcaligenaceae 28216|Betaproteobacteria S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection ybaB - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_682964_2 519989.ECTPHS_10316 1.75e-24 109.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1WX0K@135613|Chromatiales 135613|Chromatiales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5 k59_264422_1 1131730.BAVI_09741 2.55e-71 226.0 COG0334@1|root,COG0334@2|Bacteria,1TQU2@1239|Firmicutes,4HAB2@91061|Bacilli,1ZB55@1386|Bacillus 91061|Bacilli E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.20 ko:K00270 ko00350,ko00360,ko00400,ko01100,ko01110,ko01130,map00350,map00360,map00400,map01100,map01110,map01130 - R00688,R09830 RC00006 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_630774_1 498211.CJA_2165 8.27e-22 98.2 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1FFWE@10|Cellvibrio 1236|Gammaproteobacteria S Protein of unknown function (DUF1194) - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA,VWA_2 k59_1361390_1 1207063.P24_15444 3.22e-74 244.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2TSZ9@28211|Alphaproteobacteria,2JQNV@204441|Rhodospirillales 204441|Rhodospirillales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_N k59_1885_1 1163617.SCD_n00190 4.06e-31 123.0 COG2199@1|root,COG3829@1|root,COG5002@1|root,COG2199@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WH9B@28216|Betaproteobacteria 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS_4 k59_1308737_1 1247726.MIM_c29400 1.72e-06 53.1 2A4J7@1|root,315VR@2|Bacteria,1NPWX@1224|Proteobacteria,2WGX3@28216|Betaproteobacteria,3T9J4@506|Alcaligenaceae 28216|Betaproteobacteria S zinc-ribbon domain - - - - - - - - - - - - DUF3426,zinc_ribbon_4,zinc_ribbon_5 k59_1308737_2 298386.PBPRA3409 1.32e-56 187.0 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1XTMC@135623|Vibrionales 135623|Vibrionales J Methylates ribosomal protein L11 prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_1100261_2 1123500.ATUU01000006_gene1137 2.79e-11 67.0 COG0143@1|root,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,4H9VC@91061|Bacilli,4AWJS@81850|Leuconostocaceae 91061|Bacilli J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_107292_1 1240350.AMZE01000041_gene49 1.5e-28 122.0 COG4191@1|root,COG4191@2|Bacteria,1R8JK@1224|Proteobacteria,1SC56@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_525490_1 1380356.JNIK01000014_gene3174 6.9e-58 187.0 COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4EUBM@85013|Frankiales 201174|Actinobacteria K Sir2 family cobB2 - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_630785_1 1282876.BAOK01000002_gene301 1.29e-12 66.6 COG1309@1|root,COG1309@2|Bacteria,1N71J@1224|Proteobacteria,2UHJN@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - TetR_N k59_630785_2 765912.Thimo_1942 7.53e-42 153.0 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1WXBQ@135613|Chromatiales 135613|Chromatiales O PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_1516984_1 748247.AZKH_0643 8.27e-84 255.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VJBY@28216|Betaproteobacteria,2KVSB@206389|Rhodocyclales 206389|Rhodocyclales V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_577691_1 1121937.AUHJ01000005_gene2239 1.69e-79 246.0 COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,1RNYC@1236|Gammaproteobacteria,4685I@72275|Alteromonadaceae 1236|Gammaproteobacteria EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C k59_212136_1 1528106.JRJE01000032_gene3010 2.68e-26 105.0 COG0500@1|root,COG0500@2|Bacteria,1RIQB@1224|Proteobacteria,2U356@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_23 k59_212136_2 1121952.ATXT01000015_gene236 4.92e-22 100.0 COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,2GKQ8@201174|Actinobacteria,4FMBE@85023|Microbacteriaceae 201174|Actinobacteria M Glycosyl transferases group 1 - - 2.4.1.345 ko:K08256 - - R11702 - ko00000,ko01000,ko01003 - GT4 - Glyco_tranf_2_3,Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2 k59_472916_1 204669.Acid345_2210 1.23e-11 63.9 COG0720@1|root,COG0720@2|Bacteria,3Y4K2@57723|Acidobacteria,2JJD0@204432|Acidobacteriia 204432|Acidobacteriia H PFAM 6-pyruvoyl tetrahydropterin - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_472916_2 926566.Terro_2635 1.2e-27 107.0 COG0720@1|root,COG0720@2|Bacteria,3Y56Y@57723|Acidobacteria,2JJNB@204432|Acidobacteriia 204432|Acidobacteriia H PFAM 6-pyruvoyl tetrahydropterin - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_1257515_1 161528.ED21_23756 1.19e-37 143.0 COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,2U31V@28211|Alphaproteobacteria,2K3PY@204457|Sphingomonadales 204457|Sphingomonadales O heat shock protein binding - - - - - - - - - - - - - k59_1622549_1 1547437.LL06_18545 2.47e-49 166.0 COG0625@1|root,COG0625@2|Bacteria,1Q05U@1224|Proteobacteria,2U5IH@28211|Alphaproteobacteria,43I1H@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_472920_1 929713.NIASO_15580 0.000114 49.7 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1IVX6@117747|Sphingobacteriia 976|Bacteroidetes G Fibronectin type III-like domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,NAGLU,NAGLU_C,NAGLU_N k59_56185_1 1123354.AUDR01000013_gene634 1.34e-05 45.8 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2VHY3@28216|Betaproteobacteria,1KS0G@119069|Hydrogenophilales 119069|Hydrogenophilales F Queuosine biosynthesis protein QueC - - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_56185_2 545276.KB898724_gene1813 1.64e-53 185.0 COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,1RSMW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_735194_1 458817.Shal_0708 1.36e-54 193.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,2QAEU@267890|Shewanellaceae 1236|Gammaproteobacteria P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_57037_1 1038862.KB893806_gene3180 7.53e-15 77.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2TT7W@28211|Alphaproteobacteria,3JS89@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_369633_1 1173025.GEI7407_0197 9.63e-26 112.0 COG0043@1|root,COG0043@2|Bacteria,1G09E@1117|Cyanobacteria,1H8H9@1150|Oscillatoriales 1117|Cyanobacteria H Belongs to the UbiD family ubiD GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_1570670_1 985867.AEWF01000004_gene154 1.38e-50 182.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2TTGI@28211|Alphaproteobacteria,47EUX@766|Rickettsiales 766|Rickettsiales I COG0477 Permeases of the major facilitator superfamily aas - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_788328_1 436308.Nmar_1607 8.08e-109 314.0 COG1675@1|root,arCOG04270@2157|Archaea,41SJ8@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes tfe - - ko:K03136 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIE_alpha k59_473718_2 1227349.C170_16805 3.93e-15 78.6 COG1235@1|root,COG1235@2|Bacteria,1TQ8E@1239|Firmicutes,4HAKD@91061|Bacilli,26RZN@186822|Paenibacillaceae 91061|Bacilli S Metal-dependent hydrolases of the beta-lactamase superfamily I vicX - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B,Lactamase_B_2 k59_1152941_1 316055.RPE_1780 9.14e-10 58.9 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3JS0G@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ AMP-binding enzyme C-terminal domain MA20_16355 - 6.2.1.3 ko:K00666,ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1152941_2 1313172.YM304_35710 9.68e-87 264.0 COG1410@1|root,COG1410@2|Bacteria,2IC7C@201174|Actinobacteria 201174|Actinobacteria E CO dehydrogenase/acetyl-CoA synthase delta subunit - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_1466756_1 688245.CtCNB1_1280 4.09e-72 225.0 COG1024@1|root,COG1024@2|Bacteria,1PSRK@1224|Proteobacteria,2VKV4@28216|Betaproteobacteria,4AFAY@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM Enoyl-CoA hydratase isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_943821_1 243924.LT42_12175 3.5e-16 86.7 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Membrane yhdP GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - - - - - - - - - - AsmA_2,DUF3971 k59_683843_1 34506.g1912 5.55e-40 149.0 COG0007@1|root,COG0079@1|root,KOG0633@2759|Eukaryota,KOG1527@2759|Eukaryota,38FWZ@33154|Opisthokonta,3C0U5@33208|Metazoa,3DGK7@33213|Bilateria 33208|Metazoa H Tetrapyrrole (Corrin/Porphyrin) Methylases - - - - - - - - - - - - TP_methylase k59_683843_2 1121939.L861_07830 1.26e-74 239.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1XI0C@135619|Oceanospirillales 135619|Oceanospirillales H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_683843_3 269796.Rru_A0749 4.88e-11 67.8 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,2U0WS@28211|Alphaproteobacteria,2JQ4U@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_321250_1 519989.ECTPHS_10681 1.11e-52 186.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1WWQ3@135613|Chromatiales 135613|Chromatiales S DNA internalization-related competence protein ComEC Rec2 - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_1156223_1 144197.XP_008275338.1 1.26e-13 71.2 COG1028@1|root,KOG1208@2759|Eukaryota,38E7S@33154|Opisthokonta,3BE90@33208|Metazoa,3CTUW@33213|Bilateria,485H2@7711|Chordata,4918B@7742|Vertebrata,49YF5@7898|Actinopterygii 33208|Metazoa Q Dehydrogenase reductase SDR family member DHRS13 - - ko:K11169 - - - - ko00000,ko01000 - - - adh_short k59_738300_1 1286171.EAL2_c11810 5.15e-46 161.0 COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,247NS@186801|Clostridia,25VSG@186806|Eubacteriaceae 186801|Clostridia H Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C k59_1626415_2 1178825.ALIH01000003_gene2198 2.56e-21 87.0 2C9B9@1|root,32RP0@2|Bacteria,4NSK0@976|Bacteroidetes,1I3XD@117743|Flavobacteriia 976|Bacteroidetes S type III effector - - - - - - - - - - - - HopJ k59_425159_1 519989.ECTPHS_05365 1.7e-08 55.1 COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,1RNRI@1236|Gammaproteobacteria,1WYA5@135613|Chromatiales 135613|Chromatiales I Squalene phytoene synthase - - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY k59_635874_1 1004785.AMBLS11_18985 7.79e-62 207.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,465DI@72275|Alteromonadaceae 1236|Gammaproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_1156224_1 177437.HRM2_16470 2.87e-82 264.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2WJ1G@28221|Deltaproteobacteria,2MHZQ@213118|Desulfobacterales 28221|Deltaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 k59_635875_1 330214.NIDE0388 6.58e-36 127.0 COG1729@1|root,COG1729@2|Bacteria 2|Bacteria S protein trimerization - - - - - - - - - - - - FecR,TPR_16,TPR_6,WG_beta_rep k59_529290_1 987059.RBXJA2T_18071 1.06e-29 112.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2VQ06@28216|Betaproteobacteria,1KJVN@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_1573689_2 13689.BV96_02366 1.91e-53 172.0 COG2185@1|root,COG2185@2|Bacteria,1RKGS@1224|Proteobacteria,2TVS3@28211|Alphaproteobacteria,2KA21@204457|Sphingomonadales 204457|Sphingomonadales I B12 binding domain - - - - - - - - - - - - B12-binding k59_1262663_1 1048834.TC41_2761 3.39e-10 64.7 COG0637@1|root,COG0637@2|Bacteria,1VDYE@1239|Firmicutes,4HN34@91061|Bacilli 91061|Bacilli S HAD hydrolase, family IA, variant 3 - - - - - - - - - - - - HAD_2 k59_1262663_2 1476583.DEIPH_ctg079orf0129 3.63e-10 60.5 COG0120@1|root,COG0120@2|Bacteria,1WIR4@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A k59_843070_1 1280954.HPO_12863 2.59e-56 181.0 COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,2U5H3@28211|Alphaproteobacteria,43XIY@69657|Hyphomonadaceae 28211|Alphaproteobacteria G Belongs to the pseudouridine synthase RsuA family rluE - 5.4.99.20 ko:K06181 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_1262669_2 1337093.MBE-LCI_1707 7.32e-15 69.3 COG3360@1|root,COG3360@2|Bacteria,1PURT@1224|Proteobacteria,2V0YH@28211|Alphaproteobacteria,2P9ZI@245186|Loktanella 28211|Alphaproteobacteria S Dodecin - - - - - - - - - - - - Dodecin k59_1262669_3 446471.Xcel_2262 9.95e-10 56.2 COG3360@1|root,COG3360@2|Bacteria,2I0N2@201174|Actinobacteria,4F4X8@85017|Promicromonosporaceae 201174|Actinobacteria S Dodecin - - - ko:K09165 - - - - ko00000 - - - Dodecin k59_1312819_1 338963.Pcar_1616 9.66e-26 100.0 COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,42S2E@68525|delta/epsilon subdivisions,2WMT9@28221|Deltaproteobacteria,43SEX@69541|Desulfuromonadales 28221|Deltaproteobacteria F Phosphoribosyl transferase domain pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran k59_1519645_1 935557.ATYB01000014_gene3423 1.77e-16 77.8 COG0435@1|root,COG0435@2|Bacteria,1MV50@1224|Proteobacteria,2TRDE@28211|Alphaproteobacteria,4B7N6@82115|Rhizobiaceae 28211|Alphaproteobacteria O Glutathione S-transferase yqjG GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7 ko:K07393 - - - - ko00000,ko01000 - - - GST_C_2,GST_N_2 k59_1519645_2 323848.Nmul_A2329 9.22e-118 347.0 COG3001@1|root,COG3001@2|Bacteria,1MVHX@1224|Proteobacteria,2VN04@28216|Betaproteobacteria,372SJ@32003|Nitrosomonadales 28216|Betaproteobacteria G Fructosamine kinase - - - - - - - - - - - - Fructosamin_kin k59_738319_1 748658.KB907318_gene968 1.89e-66 213.0 COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,1RPUC@1236|Gammaproteobacteria,1WWIX@135613|Chromatiales 135613|Chromatiales M Mycolic acid cyclopropane synthetase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_1470788_2 485918.Cpin_2471 2e-94 286.0 COG0656@1|root,COG0656@2|Bacteria,4NK47@976|Bacteroidetes,1IWTP@117747|Sphingobacteriia 976|Bacteroidetes S PFAM aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_161836_1 555088.DealDRAFT_2933 3.57e-18 87.0 COG2358@1|root,COG2358@2|Bacteria,1TPXW@1239|Firmicutes,2489U@186801|Clostridia 186801|Clostridia S TRAP transporter solute receptor, TAXI family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_1417493_1 1120999.JONM01000010_gene4105 3.64e-76 248.0 COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,2VKA1@28216|Betaproteobacteria 28216|Betaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_998933_1 1282360.ABAC460_20380 3.89e-77 241.0 COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,2TQMC@28211|Alphaproteobacteria,2KI6V@204458|Caulobacterales 204458|Caulobacterales S PrpF protein - - 5.3.2.8 ko:K16514 ko00362,ko01120,map00362,map01120 - R07839 RC02426 ko00000,ko00001,ko01000 - - - PrpF k59_792556_2 671143.DAMO_0821 4.68e-36 134.0 COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria 2|Bacteria C Cytochrome b(N-terminal)/b6/petB petB - - ko:K00410,ko:K00412,ko:K02635,ko:K02637 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 - - ko00000,ko00001,ko00002,ko00194,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B k59_1626458_1 1122223.KB890688_gene1567 3.28e-46 166.0 COG2124@1|root,COG2124@2|Bacteria,1WIX6@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus Q cytochrome P450 - - 1.14.15.24 ko:K22492 ko00906,map00906 - R07558,R07559,R09747 RC00478,RC02629 ko00000,ko00001,ko00199,ko01000 - - - p450 k59_1262698_1 224911.27348906 2.46e-41 154.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2TVGG@28211|Alphaproteobacteria,3JSIB@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_372793_1 697281.Mahau_1719 1.2e-12 68.9 COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,42F6C@68295|Thermoanaerobacterales 186801|Clostridia L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_372793_2 1049564.TevJSym_ah00840 2.26e-17 81.3 COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria,1J5TI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins zipA GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - ko:K03528 - - - - ko00000,ko03036 - - - ZipA_C k59_1104445_2 1454004.AW11_02636 9.68e-16 70.9 COG3267@1|root,COG3267@2|Bacteria 2|Bacteria - - - - - ko:K02450,ko:K03112 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22 k59_1470811_1 1502770.JQMG01000001_gene244 9.01e-62 204.0 COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,2VHWT@28216|Betaproteobacteria,2KKQF@206350|Nitrosomonadales 206350|Nitrosomonadales EGP Nucleoside H+ symporter - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_635932_1 404589.Anae109_0668 2.07e-108 322.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2YWXD@29|Myxococcales 28221|Deltaproteobacteria NU twitching motility protein pilT-4 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_635932_2 706587.Desti_3124 6.87e-25 104.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2MQ93@213462|Syntrophobacterales 28221|Deltaproteobacteria NU TIGRFAM type IV-A pilus assembly ATPase PilB pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N,cNMP_binding k59_216081_1 1207063.P24_16857 1.53e-165 475.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQKF@204441|Rhodospirillales 204441|Rhodospirillales C III protein, CoA-transferase family - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_61422_1 1298593.TOL_2783 5.13e-54 185.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,1RNCS@1236|Gammaproteobacteria,1XH4M@135619|Oceanospirillales 135619|Oceanospirillales S Belongs to the UPF0061 (SELO) family - - - - - - - - - - - - UPF0061 k59_161856_1 1236541.BALL01000010_gene1614 3.7e-92 288.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,2Q8QB@267890|Shewanellaceae 1236|Gammaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_1417508_2 595537.Varpa_4409 9.92e-60 203.0 COG1012@1|root,COG1012@2|Bacteria,1QUBI@1224|Proteobacteria,2VM1C@28216|Betaproteobacteria,4ABP0@80864|Comamonadaceae 28216|Betaproteobacteria C Dehydrogenase - - 1.2.1.81 ko:K15515 - - - - ko00000,ko01000 - - - Aldedh k59_1156262_1 1341181.FLJC2902T_22720 6.86e-18 85.5 2DPVC@1|root,333IQ@2|Bacteria,4PPWC@976|Bacteroidetes,1IKW4@117743|Flavobacteriia,2NWZ2@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1626479_1 768671.ThimaDRAFT_2175 1.27e-57 194.0 COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,1RQWC@1236|Gammaproteobacteria,1WWH8@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0229 family - - - ko:K09786 - - - - ko00000 - - - DUF444 k59_111034_1 1210884.HG799465_gene11403 3.59e-82 255.0 COG0654@1|root,COG0654@2|Bacteria,2IXNJ@203682|Planctomycetes 203682|Planctomycetes CH FAD binding domain - - - - - - - - - - - - FAD_binding_3 k59_1210640_1 1121439.dsat_1278 4.84e-87 267.0 COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,42P7W@68525|delta/epsilon subdivisions,2WMHU@28221|Deltaproteobacteria,2M9ER@213115|Desulfovibrionales 28221|Deltaproteobacteria G TIGRFAM polysaccharide deactylase family protein, PEP-CTERM locus subfamily - - - - - - - - - - - - DUF3473,Polysacc_deac_1 k59_1210640_2 521045.Kole_1290 8.86e-09 56.6 COG2148@1|root,COG2148@2|Bacteria,2GBX7@200918|Thermotogae 200918|Thermotogae M sugar transferase - - - - - - - - - - - - Bac_transf k59_477946_5 977880.RALTA_B1993 3.37e-61 203.0 COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2VHIY@28216|Betaproteobacteria,1K1EH@119060|Burkholderiaceae 28216|Betaproteobacteria Q PFAM Taurine catabolism dioxygenase TauD TfdA tauD - 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_582326_1 1242864.D187_002314 2.42e-46 168.0 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,43DHS@68525|delta/epsilon subdivisions 1224|Proteobacteria P TonB dependent receptor yncD - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1366078_1 164328.Phyra85044 6.27e-45 168.0 COG0043@1|root,2QR5I@2759|Eukaryota,3QHUS@4776|Peronosporales 4776|Peronosporales H 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - 4.1.1.102 ko:K20039 ko00940,map00940 - R02952,R03367 RC00814 ko00000,ko00001,ko01000 - - - UbiD k59_843774_1 469383.Cwoe_4535 1.98e-55 185.0 COG1660@1|root,COG1660@2|Bacteria,2GMWB@201174|Actinobacteria,4CS0B@84995|Rubrobacteria 84995|Rubrobacteria S Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_111717_1 745310.G432_09555 2.94e-95 291.0 COG5361@1|root,COG5361@2|Bacteria,1NR2J@1224|Proteobacteria,2UPPV@28211|Alphaproteobacteria,2K216@204457|Sphingomonadales 204457|Sphingomonadales S Conserved Protein - - - - - - - - - - - - - k59_425877_1 382464.ABSI01000005_gene1162 3.99e-28 108.0 2E0ZB@1|root,32WFN@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_216863_1 1229909.NSED_01245 4.1e-71 224.0 arCOG08783@1|root,arCOG08783@2157|Archaea,41SFX@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_111727_1 1397693.KK211187_gene2462 4.81e-06 45.8 2DC3Y@1|root,2ZCTC@2|Bacteria,1U1X5@1239|Firmicutes,4IBDN@91061|Bacilli,3WFTZ@539002|Bacillales incertae sedis 91061|Bacilli - - - - - - - - - - - - - - - k59_111727_2 472759.Nhal_0917 1.38e-46 150.0 COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,1S964@1236|Gammaproteobacteria,1WYU9@135613|Chromatiales 135613|Chromatiales CO Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - - - - - - - - - - Iron_traffic k59_1211569_1 1207063.P24_01941 7.3e-60 202.0 COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2TS48@28211|Alphaproteobacteria,2JRFE@204441|Rhodospirillales 204441|Rhodospirillales G COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_321988_1 237368.SCABRO_01998 2.33e-83 265.0 COG1008@1|root,COG1008@2|Bacteria,2IX79@203682|Planctomycetes 203682|Planctomycetes C proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_1418243_1 1131266.ARWQ01000008_gene323 4.62e-24 92.8 COG0526@1|root,arCOG01972@2157|Archaea,41SSR@651137|Thaumarchaeota 651137|Thaumarchaeota O Thioredoxin - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_1418243_2 436308.Nmar_0209 2.25e-59 190.0 arCOG08023@1|root,arCOG08023@2157|Archaea,41SKK@651137|Thaumarchaeota 651137|Thaumarchaeota S Zinc finger domain - - - - - - - - - - - - zinc_ribbon_2 k59_582351_1 246197.MXAN_4662 1.42e-13 72.0 COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,42U8K@68525|delta/epsilon subdivisions,2WPZ9@28221|Deltaproteobacteria,2YV95@29|Myxococcales 28221|Deltaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_582351_2 83344.XP_007930231.1 2.65e-06 49.7 COG0596@1|root,KOG4178@2759|Eukaryota 2759|Eukaryota L 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity - - - - - - - - - - - - Abhydrolase_1 k59_636941_2 2340.JV46_13050 4.8e-71 228.0 COG1014@1|root,COG1144@1|root,COG1014@2|Bacteria,COG1144@2|Bacteria,1N12F@1224|Proteobacteria,1S7UK@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate - - 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR k59_1471753_1 1458357.BG58_37120 2.23e-51 166.0 COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,2VSE7@28216|Betaproteobacteria,1K7MJ@119060|Burkholderiaceae 28216|Betaproteobacteria J peptide chain release factor yaeJ - - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 k59_1471753_2 1266909.AUAG01000041_gene1362 2.25e-35 123.0 COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,1S5V4@1236|Gammaproteobacteria,1WYBY@135613|Chromatiales 135613|Chromatiales L PFAM HNH endonuclease - - - - - - - - - - - - HNH k59_843792_1 1123320.KB889686_gene725 4.16e-134 395.0 COG0674@1|root,COG0674@2|Bacteria,2GKXV@201174|Actinobacteria 201174|Actinobacteria C Ferredoxin oxidoreductase - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_843792_2 1116369.KB890024_gene1763 5.28e-29 105.0 COG1146@1|root,COG1146@2|Bacteria,1NGPS@1224|Proteobacteria 1224|Proteobacteria C 4Fe-4S dicluster domain - - 1.2.7.3 ko:K00176 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4 k59_1313598_3 395963.Bind_2882 1.43e-30 110.0 COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,3NBSD@45404|Beijerinckiaceae 28211|Alphaproteobacteria L PFAM transposase IS3 IS911 family protein - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_322000_1 562970.Btus_2864 5.42e-60 198.0 COG0226@1|root,COG0226@2|Bacteria,1TYCT@1239|Firmicutes,4I7GX@91061|Bacilli,279TX@186823|Alicyclobacillaceae 91061|Bacilli P Belongs to the PstS family - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_216880_1 880072.Desac_2385 9.92e-209 612.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Hydrophobe amphiphile Efflux-1 (HAE1) family bepE - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1627300_1 333138.LQ50_18150 5.85e-42 156.0 COG0745@1|root,COG4251@1|root,COG0745@2|Bacteria,COG4251@2|Bacteria,1UIHJ@1239|Firmicutes,4ISI2@91061|Bacilli,1ZSAS@1386|Bacillus 91061|Bacilli T Response regulator receiver domain - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - 4HB_MCP_1,GAF_2,HAMP,HATPase_c,HisKA,His_kinase,Response_reg k59_162601_1 204669.Acid345_1944 8.69e-78 236.0 COG1945@1|root,COG1945@2|Bacteria,3Y3KR@57723|Acidobacteria,2JIBD@204432|Acidobacteriia 204432|Acidobacteriia S Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) - - 4.1.1.19 ko:K02626 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PvlArgDC k59_947592_1 1279038.KB907340_gene1628 2.92e-79 250.0 COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2TQZC@28211|Alphaproteobacteria,2JQDS@204441|Rhodospirillales 204441|Rhodospirillales E Periplasmic binding protein - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1418262_2 172088.AUGA01000020_gene3511 2.28e-05 47.8 COG0730@1|root,COG0730@2|Bacteria,1PJR4@1224|Proteobacteria,2U231@28211|Alphaproteobacteria,3JUJ2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_477997_1 649638.Trad_1794 5.2e-74 232.0 COG1064@1|root,COG1064@2|Bacteria,1WIXW@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S PFAM Alcohol dehydrogenase GroES domain protein - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N k59_1521381_1 330214.NIDE1393 4.16e-101 305.0 COG0034@1|root,COG0034@2|Bacteria,3J0C5@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_7,Pribosyltran k59_740826_1 1238182.C882_4376 7.47e-69 216.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TT8N@28211|Alphaproteobacteria,2JQ3K@204441|Rhodospirillales 204441|Rhodospirillales E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component - - - - - - - - - - - - ABC_tran k59_531889_1 1121875.KB907548_gene1629 5.03e-65 217.0 COG0668@1|root,COG0668@2|Bacteria,4NHU7@976|Bacteroidetes,1I0RF@117743|Flavobacteriia 976|Bacteroidetes M Mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_1265929_1 644966.Tmar_1561 9.03e-132 404.0 COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,3WCCN@538999|Clostridiales incertae sedis 186801|Clostridia P ATPase, P-type (transporting), HAD superfamily, subfamily IC copA - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_740829_1 1117647.M5M_16045 1.58e-25 108.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,1RQW0@1236|Gammaproteobacteria,1J885@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_375589_1 444860.E3SJ22_9CAUD 6.63e-95 285.0 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales,4QHXI@10662|Myoviridae 10662|Myoviridae S hydrolase activity - - - - - - - - - - - - - k59_375589_2 445686.E3SL73_9CAUD 2.41e-34 122.0 4QC5H@10239|Viruses,4QVHT@35237|dsDNA viruses no RNA stage,4QPNZ@28883|Caudovirales,4QHUK@10662|Myoviridae 10662|Myoviridae S sigma factor activity - - - - - - - - - - - - - k59_639217_2 596152.DesU5LDRAFT_2181 1.55e-15 77.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,43CGH@68525|delta/epsilon subdivisions,2WJ3J@28221|Deltaproteobacteria,2M83K@213115|Desulfovibrionales 28221|Deltaproteobacteria EQ PFAM Hydantoinase B oxoprolinase hyuB - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_1106914_1 926561.KB900617_gene2071 9.44e-49 159.0 COG0614@1|root,COG0614@2|Bacteria,1VDHT@1239|Firmicutes 1239|Firmicutes P PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_3 k59_796117_1 1510531.JQJJ01000016_gene3192 1.54e-25 109.0 COG1524@1|root,COG1524@2|Bacteria,1PTI0@1224|Proteobacteria,2TUW7@28211|Alphaproteobacteria,3K6NN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_113514_1 1287116.X734_07705 8.54e-19 87.8 COG0457@1|root,COG0457@2|Bacteria,1MUMZ@1224|Proteobacteria,2TUKX@28211|Alphaproteobacteria,43IHE@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Adenylate cyclase - - - - - - - - - - - - - k59_1473998_1 1123267.JONN01000001_gene1088 1.22e-59 199.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,2K0PG@204457|Sphingomonadales 204457|Sphingomonadales C Electron transfer flavoprotein-ubiquinone oxidoreductase - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_1054586_1 330214.NIDE3582 3.16e-53 168.0 COG0278@1|root,COG0278@2|Bacteria 2|Bacteria O protein disulfide oxidoreductase activity grxD GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540 - ko:K07390 - - - - ko00000,ko03029,ko03110 - - iPC815.YPO2383,iYL1228.KPN_01992 Glutaredoxin k59_1054586_2 330214.NIDE3583 2.49e-29 107.0 COG0271@1|root,COG0271@2|Bacteria 2|Bacteria T Belongs to the BolA IbaG family bolA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0019538,GO:0022603,GO:0022604,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051604,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097428,GO:0097659,GO:0106035,GO:1901360,GO:1901362,GO:1901564,GO:1901576 - ko:K05527,ko:K22066 - - - - ko00000,ko03000,ko03029 - - - BolA k59_1054586_3 330214.NIDE3585 4.72e-79 237.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - - - - - - - - - - HATPase_c,HisKA,PAS,PIG-L,Response_reg k59_796128_1 1177181.T9A_02054 5.78e-11 65.5 COG1597@1|root,COG1597@2|Bacteria,1MY37@1224|Proteobacteria,1RMX9@1236|Gammaproteobacteria,1XP96@135619|Oceanospirillales 135619|Oceanospirillales I COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - - - - - - - - - - DAGK_cat k59_1367900_1 1123368.AUIS01000003_gene1758 5.02e-54 184.0 COG3156@1|root,COG3156@2|Bacteria,1RAQM@1224|Proteobacteria,1S2N8@1236|Gammaproteobacteria 1236|Gammaproteobacteria U COG3156 Type II secretory pathway component PulK gspK GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_375611_2 1123504.JQKD01000040_gene2804 5.52e-10 70.1 COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,2VJHS@28216|Betaproteobacteria,4AA9C@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Sulfatase - - 2.7.8.43 ko:K03760 ko01503,map01503 M00722 R11555,R11556,R11557 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DUF1705,Sulfatase k59_480298_1 1232683.ADIMK_2787 6.05e-73 234.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,4642B@72275|Alteromonadaceae 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_1265973_1 317936.Nos7107_4174 1.35e-91 281.0 COG4798@1|root,COG4798@2|Bacteria,1GCU2@1117|Cyanobacteria 1117|Cyanobacteria S methyltransferase - - - - - - - - - - - - - k59_480300_1 1379270.AUXF01000004_gene3073 0.000236 47.0 29W2Z@1|root,30HMM@2|Bacteria,1ZTXQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - k59_480300_2 1174528.JH992898_gene1982 1.23e-05 49.7 COG1116@1|root,COG1116@2|Bacteria,1G25J@1117|Cyanobacteria,1JJDQ@1189|Stigonemataceae 1117|Cyanobacteria P ABC transporter - - - ko:K15578 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16.1 - - ABC_tran k59_1106952_1 794846.AJQU01000020_gene2259 6.24e-23 95.1 COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2TR0I@28211|Alphaproteobacteria,4B7IH@82115|Rhizobiaceae 28211|Alphaproteobacteria G deacetylase - GO:0000003,GO:0000272,GO:0003006,GO:0005575,GO:0005618,GO:0005619,GO:0005623,GO:0005631,GO:0005975,GO:0005976,GO:0006022,GO:0006026,GO:0006030,GO:0006032,GO:0006037,GO:0006039,GO:0006040,GO:0006807,GO:0007049,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009272,GO:0009277,GO:0009653,GO:0009987,GO:0010383,GO:0010927,GO:0016043,GO:0016052,GO:0016998,GO:0017144,GO:0019953,GO:0022402,GO:0022411,GO:0022413,GO:0022414,GO:0022607,GO:0030154,GO:0030312,GO:0030435,GO:0030437,GO:0030476,GO:0031160,GO:0031505,GO:0032502,GO:0032505,GO:0032989,GO:0034218,GO:0034232,GO:0034293,GO:0042244,GO:0042546,GO:0042737,GO:0043170,GO:0043934,GO:0043935,GO:0044036,GO:0044085,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044277,GO:0044426,GO:0044462,GO:0044464,GO:0044703,GO:0045229,GO:0046348,GO:0048468,GO:0048646,GO:0048856,GO:0048869,GO:0051321,GO:0051704,GO:0070590,GO:0070591,GO:0070726,GO:0070910,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071852,GO:0071853,GO:0071854,GO:0071940,GO:0071944,GO:0071966,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903046 3.5.1.41 ko:K01452 ko00520,ko01100,map00520,map01100 - R02333 RC00166,RC00300 ko00000,ko00001,ko01000 - - - OHCU_decarbox,Polysacc_deac_1 k59_1106952_2 930169.B5T_03913 1.34e-38 135.0 COG3195@1|root,COG3195@2|Bacteria,1RH9S@1224|Proteobacteria,1S25P@1236|Gammaproteobacteria,1XKCJ@135619|Oceanospirillales 135619|Oceanospirillales S OHCU decarboxylase - - - - - - - - - - - - OHCU_decarbox k59_427698_1 247634.GPB2148_2468 2.68e-110 347.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,1RPFW@1236|Gammaproteobacteria,1J81X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_845593_1 751994.AGIG01000006_gene943 5.12e-98 296.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the argininosuccinate synthase family. Type argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_1055400_1 228410.NE2250 3.82e-107 327.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2VI4S@28216|Betaproteobacteria,371YG@32003|Nitrosomonadales 28216|Betaproteobacteria M TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase cpsB - 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_1055400_2 330214.NIDE4172 2.62e-07 51.2 COG0451@1|root,COG0451@2|Bacteria,3J0ZC@40117|Nitrospirae 40117|Nitrospirae M Male sterility protein - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_376437_1 1192034.CAP_7396 4.05e-45 161.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,42NRM@68525|delta/epsilon subdivisions,2WJ0S@28221|Deltaproteobacteria,2YU1B@29|Myxococcales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoH - - ko:K03086,ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1159124_1 178901.AmDm5_0041 5.71e-31 117.0 COG1011@1|root,COG1011@2|Bacteria,1NYX7@1224|Proteobacteria,2TVNX@28211|Alphaproteobacteria,2JSC6@204441|Rhodospirillales 204441|Rhodospirillales S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_1159124_2 1120956.JHZK01000004_gene1367 6.06e-89 302.0 COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,2TSIN@28211|Alphaproteobacteria,1JPPX@119043|Rhodobiaceae 28211|Alphaproteobacteria M Mechanosensitive ion channel - - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel k59_1521899_1 998674.ATTE01000001_gene4273 4.71e-38 131.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,1S5V7@1236|Gammaproteobacteria,460RJ@72273|Thiotrichales 72273|Thiotrichales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_1521899_2 279714.FuraDRAFT_3869 0.000168 43.1 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,2KQ2X@206351|Neisseriales 206351|Neisseriales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1214442_1 1380355.JNIJ01000050_gene136 4.31e-65 224.0 COG0348@1|root,COG3889@1|root,COG0348@2|Bacteria,COG3889@2|Bacteria,1R9JQ@1224|Proteobacteria,2U3WR@28211|Alphaproteobacteria,3K36U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C domain, Protein - - - - - - - - - - - - - k59_376440_1 240302.BN982_02909 1.35e-05 52.0 COG0760@1|root,COG0760@2|Bacteria,1V831@1239|Firmicutes,4HGCD@91061|Bacilli,3NEGN@45667|Halobacillus 91061|Bacilli O SurA N-terminal domain - - - - - - - - - - - - SurA_N_3 k59_219478_1 176299.Atu0641 3.65e-34 125.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2U6EM@28211|Alphaproteobacteria,4B7ZG@82115|Rhizobiaceae 28211|Alphaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_165150_1 330214.NIDE3349 3.65e-07 56.6 COG4249@1|root,COG4249@2|Bacteria,3J0QX@40117|Nitrospirae 40117|Nitrospirae S Evidence 5 No homology to any previously reported sequences - - - ko:K07126 - - - - ko00000 - - - Peptidase_C14 k59_1421401_1 1158165.KB898875_gene176 1.5e-101 311.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1WWDG@135613|Chromatiales 135613|Chromatiales E TIGRFAM Acetolactate synthase, large subunit, biosynthetic - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1421401_2 472759.Nhal_1090 1.38e-136 404.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1WXRW@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_114330_1 1121920.AUAU01000002_gene2063 2.16e-08 61.6 COG1452@1|root,COG1452@2|Bacteria,3Y37B@57723|Acidobacteria 57723|Acidobacteria M PFAM Organic solvent tolerance protein - - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA_C k59_584994_1 314230.DSM3645_17966 3.81e-90 281.0 COG0129@1|root,COG0129@2|Bacteria,2IWXV@203682|Planctomycetes 203682|Planctomycetes H Belongs to the IlvD Edd family ilvD GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_846354_2 864051.BurJ1DRAFT_0281 6.19e-18 83.2 COG0646@1|root,COG0646@2|Bacteria,1NPFY@1224|Proteobacteria,2VJ2K@28216|Betaproteobacteria,1KJQA@119065|unclassified Burkholderiales 28216|Betaproteobacteria H homocysteine S-methyltransferase metHa - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - S-methyl_trans k59_1577082_1 436308.Nmar_1498 8.73e-36 123.0 arCOG08677@1|root,arCOG08677@2157|Archaea,41SVJ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1577082_2 1229909.NSED_08240 4.81e-47 160.0 arCOG03932@1|root,arCOG03932@2157|Archaea,41SKB@651137|Thaumarchaeota 651137|Thaumarchaeota K Cobalamin B12-binding domain protein - - - - - - - - - - - - - k59_376463_1 1192034.CAP_2431 1.03e-25 108.0 COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,42MZZ@68525|delta/epsilon subdivisions,2WIQI@28221|Deltaproteobacteria 28221|Deltaproteobacteria H MoeA domain protein domain I and II - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_376463_2 1160721.RBI_I01011 2.75e-15 79.7 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,3WGK8@541000|Ruminococcaceae 186801|Clostridia KLT serine threonine protein kinase prkC - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_797286_1 1121456.ATVA01000011_gene1781 1.53e-54 192.0 COG2199@1|root,COG4191@1|root,COG3706@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PDY@68525|delta/epsilon subdivisions,2WMD0@28221|Deltaproteobacteria,2M7R7@213115|Desulfovibrionales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_797286_2 903818.KI912268_gene1090 0.000259 42.7 COG1639@1|root,COG2204@1|root,COG1639@2|Bacteria,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system phcR - - ko:K19622 ko02020,map02020 - - - ko00000,ko00001,ko02022 - - - HATPase_c,HDOD,Response_reg k59_1368662_1 247156.NFA_46000 9.32e-16 79.3 COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4FW1W@85025|Nocardiaceae 201174|Actinobacteria Q Belongs to the long-chain O-acyltransferase family tgs3 GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - DUF1298,WES_acyltransf k59_4915_1 1096546.WYO_4383 9.82e-41 150.0 COG3420@1|root,COG3420@2|Bacteria,1NU3A@1224|Proteobacteria,2UP4C@28211|Alphaproteobacteria,1JT0P@119045|Methylobacteriaceae 28211|Alphaproteobacteria P Right handed beta helix region - - - - - - - - - - - - Beta_helix k59_165176_1 7029.ACYPI005722-PA 3.72e-09 62.8 COG0457@1|root,KOG1124@2759|Eukaryota,38CY4@33154|Opisthokonta,3BAFG@33208|Metazoa,3CV6Z@33213|Bilateria,41W55@6656|Arthropoda,3SG5T@50557|Insecta,3E8F3@33342|Paraneoptera 33208|Metazoa S Domain of unknown function (DUF1736) TMTC3 GO:0001763,GO:0002009,GO:0003401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0006950,GO:0007275,GO:0008150,GO:0009653,GO:0009791,GO:0009887,GO:0009888,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010468,GO:0010604,GO:0012505,GO:0019222,GO:0030154,GO:0030162,GO:0030323,GO:0030324,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0033554,GO:0034976,GO:0035239,GO:0035295,GO:0040007,GO:0042176,GO:0042692,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0045732,GO:0045862,GO:0048286,GO:0048468,GO:0048513,GO:0048518,GO:0048522,GO:0048589,GO:0048729,GO:0048731,GO:0048747,GO:0048754,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051146,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051716,GO:0055001,GO:0055002,GO:0060255,GO:0060425,GO:0060429,GO:0060441,GO:0060447,GO:0060541,GO:0060560,GO:0060562,GO:0060602,GO:0061061,GO:0061136,GO:0061138,GO:0065007,GO:0080090,GO:1901800,GO:1903050,GO:1903052,GO:1903362,GO:1903364 - - - - - - - - - - DUF1736,TPR_1,TPR_16,TPR_2,TPR_6,TPR_8 k59_640283_2 1206725.BAFU01000246_gene2490 2.07e-60 202.0 COG0318@1|root,COG0318@2|Bacteria,2GJYP@201174|Actinobacteria,4FVK2@85025|Nocardiaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_691454_1 82996.sch_25080 2.76e-73 241.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,400DM@613|Serratia 1236|Gammaproteobacteria E Peptidase family M3 prlC GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_797295_1 710421.Mycch_3702 9.75e-41 148.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,234TN@1762|Mycobacteriaceae 201174|Actinobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_797295_2 95619.PM1_0215315 8.42e-53 172.0 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Peptidyl-prolyl cis-trans slyD GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010467,GO:0016151,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022417,GO:0031647,GO:0035821,GO:0036211,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043963,GO:0044003,GO:0044068,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044501,GO:0046872,GO:0046914,GO:0050821,GO:0050896,GO:0050897,GO:0051082,GO:0051604,GO:0051701,GO:0051704,GO:0051817,GO:0052027,GO:0052250,GO:0065007,GO:0065008,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_797295_3 549.BW31_03704 4.02e-27 100.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,3W14B@53335|Pantoea 1236|Gammaproteobacteria K Cold-shock protein cspC GO:0001072,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031554,GO:0031564,GO:0043242,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051087,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0060567,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_165181_1 266835.14023592 2.48e-21 92.0 COG0601@1|root,COG0601@2|Bacteria,1MWXF@1224|Proteobacteria,2TR7C@28211|Alphaproteobacteria,43R39@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_165181_2 1089552.KI911559_gene294 2.03e-37 140.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2JPA1@204441|Rhodospirillales 204441|Rhodospirillales P COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_1577094_1 888059.HMPREF9071_0257 6.94e-08 53.1 COG0372@1|root,COG0372@2|Bacteria,4NFXK@976|Bacteroidetes,1HWVX@117743|Flavobacteriia,1ER19@1016|Capnocytophaga 976|Bacteroidetes H citrate synthase gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_1577094_2 196367.JNFG01000006_gene6973 1.06e-62 199.0 COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2VQ7P@28216|Betaproteobacteria,1K1TA@119060|Burkholderiaceae 28216|Betaproteobacteria S Adenosyltransferase yvqK GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_1577094_3 203122.Sde_3451 1.1e-31 120.0 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,1S66F@1236|Gammaproteobacteria,467QR@72275|Alteromonadaceae 1236|Gammaproteobacteria S gag-polyprotein putative aspartyl protease - - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_741650_1 66692.ABC0363 2.92e-17 85.5 COG0584@1|root,COG0584@2|Bacteria,1UY23@1239|Firmicutes,4HEAD@91061|Bacilli,1ZCIE@1386|Bacillus 91061|Bacilli C glycerophosphoryl diester phosphodiesterase yhdW - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_950238_2 983545.Glaag_2197 3.55e-46 157.0 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,466TY@72275|Alteromonadaceae 1236|Gammaproteobacteria S Cytochrome C biogenesis protein transmembrane region braZ - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_640312_2 392499.Swit_4156 7.34e-13 68.2 COG2141@1|root,COG2141@2|Bacteria,1MUTJ@1224|Proteobacteria,2TTZI@28211|Alphaproteobacteria,2K8R6@204457|Sphingomonadales 204457|Sphingomonadales C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_324652_1 330214.NIDE2734 3.74e-51 186.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,3J0VB@40117|Nitrospirae 40117|Nitrospirae S Competence protein - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,Lactamase_B k59_324652_2 716544.wcw_0415 2.39e-28 114.0 COG1109@1|root,COG1109@2|Bacteria,2JFS2@204428|Chlamydiae 204428|Chlamydiae G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1368690_1 338963.Pcar_1247 6.94e-57 188.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,42MKD@68525|delta/epsilon subdivisions,2WIZP@28221|Deltaproteobacteria,43SDU@69541|Desulfuromonadales 28221|Deltaproteobacteria J PCRF prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_957367_1 330214.NIDE3016 6.15e-126 362.0 COG1209@1|root,COG1209@2|Bacteria,3J0KX@40117|Nitrospirae 40117|Nitrospirae M Nucleotidyl transferase - - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_1222242_1 331869.BAL199_30007 2.98e-93 289.0 COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria,4BRTX@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Amidase - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_8455_1 1285583.CCASEI_02345 1.46e-20 94.0 COG0407@1|root,COG0407@2|Bacteria,2GMY6@201174|Actinobacteria,22KH9@1653|Corynebacteriaceae 201174|Actinobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_854717_1 84531.JMTZ01000006_gene3463 6.18e-38 144.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1X43V@135614|Xanthomonadales 135614|Xanthomonadales CO Thiol disulfide Interchange Protein dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_76439_1 1249627.D779_0329 4.35e-74 226.0 COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,1WY7V@135613|Chromatiales 135613|Chromatiales H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC k59_76439_2 1000565.METUNv1_01405 4.56e-10 56.6 COG2154@1|root,COG2154@2|Bacteria,1RIEN@1224|Proteobacteria,2VRX8@28216|Betaproteobacteria,2KYU2@206389|Rhodocyclales 206389|Rhodocyclales H Pterin 4 alpha carbinolamine dehydratase - - - - - - - - - - - - Pterin_4a k59_492176_1 1382303.JPOM01000001_gene2275 3.17e-24 100.0 COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2U3PD@28211|Alphaproteobacteria,2KG4N@204458|Caulobacterales 204458|Caulobacterales S PFAM 2-nitropropane dioxygenase NPD - - 1.3.1.9 ko:K02371 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO k59_492176_2 595460.RRSWK_04882 4.19e-33 123.0 COG0631@1|root,COG0631@2|Bacteria 2|Bacteria T protein serine/threonine phosphatase activity - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_437481_1 344747.PM8797T_14414 5.62e-81 256.0 COG3961@1|root,COG3961@2|Bacteria,2IY2K@203682|Planctomycetes 2|Bacteria C Belongs to the TPP enzyme family pdc - 4.1.1.1 ko:K01568 ko00010,ko01100,ko01110,ko01130,map00010,map01100,map01110,map01130 - R00014,R00755 RC00027,RC00375,RC02744 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_958291_1 927658.AJUM01000037_gene2135 3.69e-12 67.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,4NFRF@976|Bacteroidetes,2FMI7@200643|Bacteroidia,3XJS4@558415|Marinilabiliaceae 976|Bacteroidetes E B12 binding domain metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_958291_2 1379270.AUXF01000004_gene3330 1.79e-41 152.0 COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1ZT6C@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Methylenetetrahydrofolate reductase - - 1.5.1.20,2.1.1.10 ko:K00297,ko:K00547 ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523 M00377 R00650,R01224,R07168 RC00003,RC00035,RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR,S-methyl_trans k59_386961_1 595460.RRSWK_03637 2.86e-65 212.0 COG3328@1|root,COG3328@2|Bacteria,2J0T4@203682|Planctomycetes 203682|Planctomycetes L COG3328 Transposase and inactivated derivatives - - - - - - - - - - - - Transposase_mut k59_1278085_1 876044.IMCC3088_71 6.7e-69 228.0 28HMZ@1|root,2Z7WD@2|Bacteria 2|Bacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_76458_1 1229909.NSED_07245 1.26e-139 397.0 COG1024@1|root,arCOG00239@2157|Archaea,41SH7@651137|Thaumarchaeota 651137|Thaumarchaeota I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.116 ko:K15019 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00375 R03045 RC00834 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_76458_2 436308.Nmar_1305 2.89e-13 67.8 arCOG08805@1|root,arCOG08805@2157|Archaea,41T3X@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_651115_1 1408164.MOLA814_00003 7.26e-47 165.0 COG1622@1|root,COG2863@1|root,COG1622@2|Bacteria,COG2863@2|Bacteria,1MVYW@1224|Proteobacteria,2VIDQ@28216|Betaproteobacteria 28216|Betaproteobacteria C cytochrome c oxidase (Subunit II) coxM - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,Cytochrom_C k59_958308_1 1007104.SUS17_2464 5.13e-09 62.0 COG0760@1|root,COG0760@2|Bacteria,1PPK9@1224|Proteobacteria,2UPWD@28211|Alphaproteobacteria 28211|Alphaproteobacteria O PPIC-type PPIASE domain - - - - - - - - - - - - Rotamase_2 k59_651118_2 1379698.RBG1_1C00001G0296 5e-98 292.0 COG0437@1|root,COG0437@2|Bacteria,2NR78@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S binding domain ttrB - - ko:K08358 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Fer4_11,Fer4_3,Fer4_7 k59_1278098_2 1453501.JELR01000001_gene2989 1.1e-18 85.9 COG0446@1|root,COG1773@1|root,COG0446@2|Bacteria,COG1773@2|Bacteria,1NR3M@1224|Proteobacteria,1RQ07@1236|Gammaproteobacteria,46561@72275|Alteromonadaceae 1236|Gammaproteobacteria C NAD(FAD)-dependent dehydrogenases rubB - 1.18.1.1 ko:K05297 ko00071,map00071 - R02000 - ko00000,ko00001,ko01000 - - - Pyr_redox_2,Rubredoxin k59_492209_2 663610.JQKO01000012_gene3077 4.48e-74 228.0 COG1028@1|root,COG1028@2|Bacteria,1MWJQ@1224|Proteobacteria,2TVRP@28211|Alphaproteobacteria,3ND17@45404|Beijerinckiaceae 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_124641_2 1254432.SCE1572_05510 8.01e-49 165.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_124641_3 595460.RRSWK_00518 6.86e-14 68.6 COG2128@1|root,COG2128@2|Bacteria,2IYUM@203682|Planctomycetes 203682|Planctomycetes O Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_1064051_1 330214.NIDE2582 7.87e-119 374.0 COG0587@1|root,COG0587@2|Bacteria,3J0FE@40117|Nitrospirae 40117|Nitrospirae L DNA-directed DNA polymerase - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1223537_1 1229909.NSED_04285 7.74e-141 405.0 COG1759@1|root,arCOG04346@2157|Archaea,41S79@651137|Thaumarchaeota 651137|Thaumarchaeota F Domain of unknown function (DUF1297) - - 6.3.4.23 ko:K06863 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R06975 RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 - - - DUF1246,DUF1297 k59_651125_1 1158338.JNLJ01000001_gene645 1.94e-13 70.9 COG0805@1|root,COG0805@2|Bacteria,2G41B@200783|Aquificae 200783|Aquificae U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes tatC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_651125_2 1232410.KI421420_gene3180 2.28e-12 68.2 COG1826@1|root,COG1826@2|Bacteria,1NI3F@1224|Proteobacteria,42VIZ@68525|delta/epsilon subdivisions,2WRC5@28221|Deltaproteobacteria,43SSF@69541|Desulfuromonadales 28221|Deltaproteobacteria U mttA/Hcf106 family tatB - - ko:K03116,ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_651129_1 1229909.NSED_08945 3.32e-144 438.0 COG4257@1|root,arCOG06267@1|root,arCOG03564@2157|Archaea,arCOG06267@2157|Archaea,41S5S@651137|Thaumarchaeota 651137|Thaumarchaeota V resistance protein - - - ko:K14166 - - - - ko00000,ko02000 - - - CopC,CopD k59_1278115_1 396588.Tgr7_0028 1.15e-64 210.0 COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1WWAM@135613|Chromatiales 135613|Chromatiales H Uroporphyrinogen III synthase - - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 k59_907154_1 553385.JEMF01000006_gene3366 1.15e-29 109.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,1S22R@1236|Gammaproteobacteria,1XJ66@135619|Oceanospirillales 135619|Oceanospirillales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_907154_2 596330.HMPREF0628_0282 1.01e-23 96.3 COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,247JB@186801|Clostridia,22GRD@1570339|Peptoniphilaceae 186801|Clostridia J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_227697_2 159087.Daro_3774 9.62e-12 65.5 COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2VSFR@28216|Betaproteobacteria,2KYYH@206389|Rhodocyclales 206389|Rhodocyclales M Thioredoxin-like - - - - - - - - - - - - Redoxin k59_1638806_1 67352.JODS01000002_gene1467 7.67e-16 78.6 COG2267@1|root,COG2267@2|Bacteria,2GJSU@201174|Actinobacteria 201174|Actinobacteria I Alpha beta hydrolase hpx - 1.11.1.10 ko:K00433 - - - - ko00000,ko01000 - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 k59_1011020_2 1123288.SOV_6c01240 6.55e-25 107.0 COG5449@1|root,COG5449@2|Bacteria,1V3FR@1239|Firmicutes,4H40I@909932|Negativicutes 909932|Negativicutes S Phage conserved hypothetical protein BR0599 - - - - - - - - - - - - DUF2163,Phage_BR0599 k59_1585601_1 243231.GSU0363 4.58e-19 91.3 COG1199@1|root,COG2003@1|root,COG1199@2|Bacteria,COG2003@2|Bacteria,1MVCU@1224|Proteobacteria,42N57@68525|delta/epsilon subdivisions,2WJ82@28221|Deltaproteobacteria,43U02@69541|Desulfuromonadales 28221|Deltaproteobacteria KL HELICc2 dinG - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,RadC,ResIII k59_1278130_1 926560.KE387023_gene2289 3.52e-67 219.0 COG3852@1|root,COG3852@2|Bacteria,1WMD2@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c k59_958337_1 1499967.BAYZ01000160_gene414 8.85e-93 288.0 COG1524@1|root,COG1524@2|Bacteria,2NQ0M@2323|unclassified Bacteria 2|Bacteria S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_1527630_2 1121935.AQXX01000118_gene4933 1.85e-50 173.0 COG2304@1|root,COG2304@2|Bacteria,1N2UU@1224|Proteobacteria,1RXGJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S von willebrand factor, type A - - 2.7.11.1 ko:K11912 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - VWA_2 k59_699809_1 1173026.Glo7428_3845 2.37e-08 60.1 COG1309@1|root,COG1309@2|Bacteria,1G4S5@1117|Cyanobacteria 1117|Cyanobacteria K PFAM Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_227701_2 1313172.YM304_01690 8.58e-06 52.8 COG0778@1|root,COG3832@1|root,COG0778@2|Bacteria,COG3832@2|Bacteria,2HI8Q@201174|Actinobacteria 201174|Actinobacteria C Nitroreductase - - - - - - - - - - - - Nitroreductase k59_699812_1 391615.ABSJ01000059_gene2184 9.36e-93 290.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1J4XI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0000166,GO:0000900,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004812,GO:0004829,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006435,GO:0006446,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0017076,GO:0017148,GO:0019222,GO:0019538,GO:0019752,GO:0030371,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032553,GO:0032555,GO:0032559,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045182,GO:0045947,GO:0046483,GO:0046872,GO:0046914,GO:0048027,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090079,GO:0090304,GO:0097159,GO:0097367,GO:0106074,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iPC815.YPO2433,iSDY_1059.SDY_1814 HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_1485869_1 1245469.S58_08800 1.5e-10 62.8 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2U7GY@28211|Alphaproteobacteria,3JYH8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria NU general secretion pathway protein G - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_1527638_1 1123368.AUIS01000037_gene22 4.31e-121 360.0 COG2960@1|root,COG2960@2|Bacteria,1NJYD@1224|Proteobacteria,1RYI7@1236|Gammaproteobacteria 1236|Gammaproteobacteria M long-chain fatty acid transporting porin activity - - - - - - - - - - - - - k59_958356_1 43354.JOIJ01000006_gene1917 0.000155 44.3 COG0604@1|root,COG0604@2|Bacteria,2GMHR@201174|Actinobacteria,4EEEE@85010|Pseudonocardiales 201174|Actinobacteria C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_958356_2 118168.MC7420_2796 2.84e-12 70.9 COG2211@1|root,COG2211@2|Bacteria,1G0T0@1117|Cyanobacteria,1H9W2@1150|Oscillatoriales 1117|Cyanobacteria G MFS/sugar transport protein - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_907190_1 555793.WSK_1442 1.89e-15 79.7 28NHI@1|root,2ZBJA@2|Bacteria,1RCPZ@1224|Proteobacteria,2UKQP@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_227729_2 543728.Vapar_5836 6.25e-33 124.0 COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,2VHJU@28216|Betaproteobacteria,4AB94@80864|Comamonadaceae 28216|Betaproteobacteria L Transposase zinc-ribbon domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_1223607_1 1229909.NSED_08075 3.26e-37 128.0 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_808330_1 929712.KI912613_gene2456 7.51e-47 172.0 COG2244@1|root,COG2244@2|Bacteria,2H55P@201174|Actinobacteria,4CT24@84995|Rubrobacteria 84995|Rubrobacteria S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt_3 k59_1638860_2 1000565.METUNv1_02095 1.84e-29 114.0 COG1999@1|root,COG1999@2|Bacteria,1RHK3@1224|Proteobacteria,2VRBY@28216|Betaproteobacteria,2KWU1@206389|Rhodocyclales 206389|Rhodocyclales S signal sequence binding - - - - - - - - - - - - - k59_437595_2 1128421.JAGA01000001_gene2365 8.51e-106 322.0 COG1600@1|root,COG1600@2|Bacteria,2NNWV@2323|unclassified Bacteria 2|Bacteria C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_1165769_1 1191523.MROS_2033 8.66e-87 269.0 COG1005@1|root,COG1005@2|Bacteria 2|Bacteria C quinone binding nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_1165769_2 266117.Rxyl_1582 1.63e-09 58.2 COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CPIQ@84995|Rubrobacteria 84995|Rubrobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_172846_1 1230343.CANP01000048_gene3673 9.49e-94 292.0 COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,1RSC3@1236|Gammaproteobacteria,1JDAH@118969|Legionellales 118969|Legionellales C D-arabinono-1,4-lactone oxidase - - - - - - - - - - - - ALO,FAD_binding_4 k59_1278192_1 1223545.GS4_03_01830 0.00086 41.2 COG0031@1|root,COG0031@2|Bacteria,2GZSN@201174|Actinobacteria,4GG43@85026|Gordoniaceae 201174|Actinobacteria E Pyridoxal-phosphate dependent enzyme - - 4.2.1.22 ko:K01697 ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 M00035,M00338 R00891,R01290,R04942 RC00056,RC00069,RC00256,RC00489,RC01246 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_651217_1 1267535.KB906767_gene812 1.01e-45 166.0 COG3379@1|root,COG3379@2|Bacteria 2|Bacteria S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_958384_1 436308.Nmar_0272 6.46e-42 150.0 COG4799@1|root,arCOG02705@2157|Archaea,41SEH@651137|Thaumarchaeota 651137|Thaumarchaeota I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - 2.1.3.15,6.4.1.2,6.4.1.3 ko:K18604 ko00720,ko01120,map00720,map01120 - R00742,R01859 RC00040,RC00097,RC00367,RC00609 ko00000,ko00001,ko01000 - - - Carboxyl_trans k59_958384_2 1229909.NSED_01235 2.12e-44 151.0 COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota 651137|Thaumarchaeota C oxidoreductase FAD NAD(P)-binding - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_854853_1 1167006.UWK_02097 1.36e-65 216.0 COG3894@1|root,COG3894@2|Bacteria,1MX9D@1224|Proteobacteria,42PW1@68525|delta/epsilon subdivisions,2WJZD@28221|Deltaproteobacteria,2MHZX@213118|Desulfobacterales 28221|Deltaproteobacteria C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445 k59_1223632_1 1323361.JPOC01000028_gene3987 1.23e-103 327.0 COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,4FW1X@85025|Nocardiaceae 201174|Actinobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1064140_1 765912.Thimo_1176 6.59e-31 119.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1WW7U@135613|Chromatiales 135613|Chromatiales E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_1064140_2 765913.ThidrDRAFT_0669 0.000959 42.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1WW6P@135613|Chromatiales 135613|Chromatiales E Belongs to the TrpC family trpC - 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS,PRAI k59_280520_1 1282360.ABAC460_08385 1.06e-67 228.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2TRH3@28211|Alphaproteobacteria,2KF6S@204458|Caulobacterales 204458|Caulobacterales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_332980_1 1396141.BATP01000034_gene4218 5.32e-70 226.0 COG3119@1|root,COG3119@2|Bacteria,46Z2W@74201|Verrucomicrobia,2IWNY@203494|Verrucomicrobiae 203494|Verrucomicrobiae P Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_387113_1 1379270.AUXF01000004_gene2931 1.55e-30 124.0 COG2866@1|root,COG2866@2|Bacteria,1ZUNB@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_1223636_1 1144275.COCOR_05572 7.03e-80 251.0 COG1475@1|root,COG1475@2|Bacteria 2|Bacteria K chromosome segregation - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_1223636_2 266117.Rxyl_0794 3.95e-28 105.0 COG1254@1|root,COG1254@2|Bacteria,2IT6J@201174|Actinobacteria,4CTJ9@84995|Rubrobacteria 84995|Rubrobacteria C Acylphosphatase - - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase k59_394809_1 765913.ThidrDRAFT_0050 3.22e-63 206.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1WWZH@135613|Chromatiales 135613|Chromatiales EH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_1443339_1 395493.BegalDRAFT_2643 2.49e-41 147.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,460JS@72273|Thiotrichales 72273|Thiotrichales S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_236364_1 396588.Tgr7_0372 8.65e-56 196.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1WWWW@135613|Chromatiales 135613|Chromatiales CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_134973_1 1317118.ATO8_16525 3.22e-30 120.0 COG2084@1|root,COG2084@2|Bacteria,1MX8V@1224|Proteobacteria,2TVBS@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Dehydrogenase MA20_26655 - - - - - - - - - - - DUF1932,F420_oxidored,NAD_binding_2 k59_1384819_1 1131269.AQVV01000003_gene734 1.23e-09 64.7 COG1508@1|root,COG1508@2|Bacteria 2|Bacteria K bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_1534882_1 330214.NIDE0474 4.67e-78 244.0 COG1181@1|root,COG1181@2|Bacteria 2|Bacteria F Belongs to the D-alanine--D-alanine ligase family ddlB1 - 6.3.2.4,6.3.5.5 ko:K01921,ko:K01955 ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502 M00051 R00256,R00575,R01150,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000,ko01011 - - - Dala_Dala_lig_C k59_1073347_2 1385517.N800_03555 9.21e-48 167.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1X3C1@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1125389_1 1380391.JIAS01000018_gene807 8.32e-43 151.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2TSUR@28211|Alphaproteobacteria,2JPZY@204441|Rhodospirillales 204441|Rhodospirillales V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_88295_1 1123060.JONP01000004_gene666 1.03e-34 127.0 2E13Z@1|root,32WJ8@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_88295_2 247633.GP2143_04008 8.97e-50 169.0 COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,1RMYP@1236|Gammaproteobacteria,1J4W1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2515 1-aminocyclopropane-1-carboxylate deaminase - - 4.4.1.15 ko:K05396 ko00270,map00270 - R01874 RC00382 ko00000,ko00001,ko01000 - - - PALP k59_394829_1 522306.CAP2UW1_0038 3.77e-38 154.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,1KPP8@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria L DNA topoisomerase III topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - SWIB,Topoisom_bac,Toprim,Toprim_Crpt k59_1019806_1 1205680.CAKO01000029_gene4978 5.88e-84 259.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,2JPPM@204441|Rhodospirillales 204441|Rhodospirillales I COG1960 Acyl-CoA dehydrogenases - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1594287_1 519989.ECTPHS_07326 4.75e-104 323.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales 135613|Chromatiales L PFAM UvrD REP helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1651178_2 396588.Tgr7_0332 5.57e-113 337.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXE7@135613|Chromatiales 135613|Chromatiales GM NAD-dependent epimerase dehydratase - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Epimerase,NAD_binding_10 k59_1651178_3 519989.ECTPHS_06637 1.08e-05 48.9 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1WX5E@135613|Chromatiales 135613|Chromatiales M PFAM Lytic - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_289926_1 743721.Psesu_0598 6.75e-45 150.0 COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,1S40D@1236|Gammaproteobacteria,1X50D@135614|Xanthomonadales 135614|Xanthomonadales S adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_88311_2 247633.GP2143_18001 1.95e-75 251.0 COG0439@1|root,COG1038@1|root,COG4799@1|root,COG0439@2|Bacteria,COG1038@2|Bacteria,COG4799@2|Bacteria,1MU4H@1224|Proteobacteria,1RQ9Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Biotin carboxylase pyc - - - - - - - - - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans k59_504499_1 395493.BegalDRAFT_3541 0.000144 47.0 COG5373@1|root,COG5373@2|Bacteria,1QZY0@1224|Proteobacteria 1224|Proteobacteria S Type II secretion system protein B - - - ko:K02451 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - T2SSB k59_394837_1 333138.LQ50_21010 3.94e-96 293.0 COG0006@1|root,COG0006@2|Bacteria,1TSN0@1239|Firmicutes,4HCA3@91061|Bacilli,1ZAZR@1386|Bacillus 91061|Bacilli E Creatinase/Prolidase N-terminal domain - - 3.4.13.9 ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_179995_2 502025.Hoch_3156 3.72e-31 118.0 2E13Z@1|root,32WJ8@2|Bacteria,1NYI6@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_967183_1 378806.STAUR_3333 4.85e-43 150.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,42N99@68525|delta/epsilon subdivisions,2WJY8@28221|Deltaproteobacteria,2YTVB@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_758603_1 330214.NIDE3964 4.83e-28 110.0 COG0026@1|root,COG0026@2|Bacteria,3J11N@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_758603_2 330214.NIDE3965 8.71e-23 93.2 COG0041@1|root,COG0041@2|Bacteria,3J0P8@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_1234219_1 1120931.KB893934_gene782 7.97e-36 132.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,1RMBA@1236|Gammaproteobacteria,1Y82E@135625|Pasteurellales 135625|Pasteurellales E 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase metE - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_2 k59_1651180_1 1123368.AUIS01000026_gene1457 4.58e-74 229.0 COG0500@1|root,COG2226@2|Bacteria,1QZJB@1224|Proteobacteria,1SHWN@1236|Gammaproteobacteria,2NCWT@225057|Acidithiobacillales 225057|Acidithiobacillales Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_25 k59_1651180_3 1049564.TevJSym_ac01870 1.13e-157 457.0 COG1533@1|root,COG1533@2|Bacteria,1NWJ9@1224|Proteobacteria 1224|Proteobacteria L radical SAM domain protein - - 4.1.99.14 ko:K03716 - - - - ko00000,ko01000 - - - - k59_1651180_4 396595.TK90_2100 2.29e-23 92.0 COG2026@1|root,COG2026@2|Bacteria,1N80B@1224|Proteobacteria,1SDK6@1236|Gammaproteobacteria,1WZ7U@135613|Chromatiales 135613|Chromatiales DJ PFAM plasmid - - - ko:K06218 - - - - ko00000,ko02048 - - - ParE_toxin k59_1651180_5 717772.THIAE_04695 5.2e-20 82.8 2E9PU@1|root,333W6@2|Bacteria,1N6VC@1224|Proteobacteria,1SCC9@1236|Gammaproteobacteria,462YX@72273|Thiotrichales 72273|Thiotrichales - - - - - - - - - - - - - - - k59_180006_2 456442.Mboo_1995 2.77e-39 143.0 COG0626@1|root,arCOG00060@2157|Archaea,2Y3AD@28890|Euryarchaeota,2NBH7@224756|Methanomicrobia 224756|Methanomicrobia E aromatic amino acid beta-eliminating lyase threonine aldolase - - 4.4.1.11 ko:K01761 ko00270,ko00450,map00270,map00450 - R00654,R04770 RC00196,RC00348,RC01209,RC01210 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_1594309_1 243231.GSU1793 3.24e-11 67.8 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,42MBB@68525|delta/epsilon subdivisions,2WIU1@28221|Deltaproteobacteria,43UEM@69541|Desulfuromonadales 28221|Deltaproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_1234230_1 1540095.A0A0A0YVF7_9CAUD 6.29e-40 145.0 4QFV7@10239|Viruses,4QPPE@28883|Caudovirales,4QIND@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_135040_1 1379270.AUXF01000006_gene5 4.27e-105 327.0 COG0317@1|root,COG0317@2|Bacteria,1ZT5M@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_967198_3 1229909.NSED_08175 4.31e-11 61.2 arCOG08639@1|root,arCOG08639@2157|Archaea,41SP8@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_236419_1 670487.Ocepr_0031 4.3e-68 214.0 COG1392@1|root,COG1392@2|Bacteria 2|Bacteria P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_916717_1 326442.PSHAa2267 4.46e-26 107.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,2PZW7@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria U COG3267 Type II secretory pathway, component ExeA gspA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1,T2SSB k59_289957_1 215803.DB30_0647 7.85e-81 269.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2YUJI@29|Myxococcales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1443390_1 1283300.ATXB01000001_gene2176 1.84e-130 397.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1XEJP@135618|Methylococcales 135618|Methylococcales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1125439_1 314278.NB231_10929 1.5e-220 636.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_504543_1 394221.Mmar10_0249 1.11e-65 221.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria,43W98@69657|Hyphomonadaceae 28211|Alphaproteobacteria G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_820562_1 880072.Desac_0500 3.1e-57 191.0 COG1804@1|root,COG1804@2|Bacteria,1NWFC@1224|Proteobacteria,4300F@68525|delta/epsilon subdivisions,2X2A6@28221|Deltaproteobacteria,2MRS4@213462|Syntrophobacterales 28221|Deltaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_1384876_1 1121447.JONL01000011_gene2351 9.65e-05 47.8 COG2050@1|root,COG2050@2|Bacteria,1RHK6@1224|Proteobacteria,43B5Q@68525|delta/epsilon subdivisions,2X6J9@28221|Deltaproteobacteria,2MH3Q@213115|Desulfovibrionales 28221|Deltaproteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_1384876_2 366602.Caul_5303 1.56e-65 211.0 COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2TSWA@28211|Alphaproteobacteria,2KF1F@204458|Caulobacterales 204458|Caulobacterales E Converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH tdh - 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_289967_1 991905.SL003B_0492 5.58e-129 380.0 COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,2TVIR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L hmm pf01609 - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_602160_1 330214.NIDE1573 1.19e-24 95.5 COG0314@1|root,COG0314@2|Bacteria,3J1AN@40117|Nitrospirae 40117|Nitrospirae H MoaE protein - - 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE k59_602160_2 330214.NIDE1574 2.73e-48 164.0 COG2896@1|root,COG2896@2|Bacteria,3J0PB@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_14,Mob_synth_C,Radical_SAM k59_1534932_1 383372.Rcas_0295 2.02e-30 124.0 COG0260@1|root,COG0260@2|Bacteria,2G617@200795|Chloroflexi,37528@32061|Chloroflexia 32061|Chloroflexia E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_1652762_1 1449353.JQMQ01000005_gene5458 2.53e-07 57.4 COG1011@1|root,COG1011@2|Bacteria,2GN5U@201174|Actinobacteria,2NIFK@228398|Streptacidiphilus 201174|Actinobacteria S HAD-hyrolase-like - - - ko:K07025 - - - - ko00000 - - - HAD_2,Hydrolase k59_343683_2 234831.PSM_A0070 1.96e-18 85.5 COG1770@1|root,COG1770@2|Bacteria,1MUED@1224|Proteobacteria,1RMSV@1236|Gammaproteobacteria,2Q08N@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E Protease II ptrB GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_603122_1 672.VV93_v1c31510 1.52e-47 164.0 COG1404@1|root,COG1404@2|Bacteria,1R5Y1@1224|Proteobacteria,1SEMA@1236|Gammaproteobacteria,1XU06@135623|Vibrionales 135623|Vibrionales O Subtilisin-like serine - - - - - - - - - - - - - k59_1174183_1 330214.NIDE0226 7.81e-101 307.0 COG1008@1|root,COG1008@2|Bacteria,3J0EQ@40117|Nitrospirae 2|Bacteria C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism ndhD - 1.6.5.3 ko:K00342,ko:K05575 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iJN678.ndhD2 Oxidored_q5_N,Proton_antipo_M k59_1444442_1 663321.REG_1443 3.03e-09 59.7 2DBFF@1|root,2Z8YA@2|Bacteria 2|Bacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_4,HTH_Tnp_4 k59_90059_2 713586.KB900536_gene1804 5.85e-28 114.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1WXM6@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_1535880_1 502025.Hoch_4729 2.09e-36 130.0 COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,1RGUX@1224|Proteobacteria,437BZ@68525|delta/epsilon subdivisions,2WQNB@28221|Deltaproteobacteria,2YVJC@29|Myxococcales 28221|Deltaproteobacteria H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin moaD - 2.8.1.12 ko:K03635,ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE,ThiS k59_1535880_2 1536774.H70357_20635 1.38e-11 63.5 COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,4HH5V@91061|Bacilli,26VDH@186822|Paenibacillaceae 91061|Bacilli H May be involved in the biosynthesis of molybdopterin moaB - 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_343709_1 483219.LILAB_24510 2.28e-71 221.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria 1224|Proteobacteria L HNH endonuclease MA20_20605 - - - - - - - - - - - HNH,HNH_5 k59_343723_1 864051.BurJ1DRAFT_1621 3.28e-40 143.0 COG0406@1|root,COG0406@2|Bacteria,1N83T@1224|Proteobacteria,2VY3M@28216|Betaproteobacteria 28216|Betaproteobacteria G PFAM Phosphoglycerate mutase - - - - - - - - - - - - His_Phos_1 k59_136550_1 264203.ZMO1548 7.51e-54 189.0 COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,2TRF3@28211|Alphaproteobacteria,2K06U@204457|Sphingomonadales 204457|Sphingomonadales I PFAM Prenyltransferase squalene oxidase - - 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 - R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 - - - SQHop_cyclase_C,SQHop_cyclase_N k59_1330516_1 754477.Q7C_290 4.28e-18 81.3 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,46088@72273|Thiotrichales 72273|Thiotrichales M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_1330516_2 1405.DJ92_2181 1.83e-55 186.0 COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,4HAKI@91061|Bacilli,1ZAZB@1386|Bacillus 91061|Bacilli G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_1127158_1 1211815.CBYP010000063_gene1853 2.41e-18 79.0 COG3631@1|root,COG3631@2|Bacteria,2IHRM@201174|Actinobacteria 201174|Actinobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 k59_1127158_3 994479.GL877878_gene938 2.17e-47 159.0 COG0494@1|root,COG0494@2|Bacteria,2II41@201174|Actinobacteria,4E3KS@85010|Pseudonocardiales 201174|Actinobacteria L NUDIX domain - - - - - - - - - - - - NUDIX k59_1595407_1 472759.Nhal_2482 1.76e-30 116.0 COG3823@1|root,COG3823@2|Bacteria,1R9YU@1224|Proteobacteria,1RZ5N@1236|Gammaproteobacteria,1WXPE@135613|Chromatiales 135613|Chromatiales O PFAM Glutamine cyclotransferase - - - - - - - - - - - - Glu_cyclase_2 k59_1499587_2 436308.Nmar_1627 1.84e-112 348.0 COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,41SAH@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_968320_3 1357714.A0A067XQW1_9CAUD 8.66e-31 122.0 4QBX5@10239|Viruses,4QVS2@35237|dsDNA viruses no RNA stage,4QQR3@28883|Caudovirales,4QHZ6@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_13850_1 1245471.PCA10_13740 1.58e-69 222.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,1RPZ9@1236|Gammaproteobacteria,1YIBT@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1535901_1 105559.Nwat_1681 4.6e-120 370.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,LysM k59_313578_1 637389.Acaty_c2281 5.39e-95 298.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,2NE68@225057|Acidithiobacillales 225057|Acidithiobacillales P STAS domain - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_418059_2 926566.Terro_0354 8.9e-13 71.2 COG0571@1|root,COG0571@2|Bacteria,3Y4M2@57723|Acidobacteria,2JJ95@204432|Acidobacteriia 204432|Acidobacteriia K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc - 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_1201663_1 1049564.TevJSym_bq00030 5.98e-42 154.0 COG1385@1|root,COG4660@1|root,COG1385@2|Bacteria,COG4660@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1J5UQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_104620_1 96561.Dole_1200 9.33e-43 156.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42PY9@68525|delta/epsilon subdivisions,2WQIW@28221|Deltaproteobacteria 28221|Deltaproteobacteria H coenzyme F390 - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - - k59_52483_4 1244869.H261_14265 2.46e-18 80.9 COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,2U7TH@28211|Alphaproteobacteria,2JZTU@204441|Rhodospirillales 204441|Rhodospirillales L IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_52483_5 76114.ebA690 2.83e-08 57.4 COG3436@1|root,COG3436@2|Bacteria,1MYAC@1224|Proteobacteria,2VMF3@28216|Betaproteobacteria,2KXTT@206389|Rhodocyclales 206389|Rhodocyclales L COG3436 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_1201667_1 1168065.DOK_02746 4.26e-10 61.2 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1J8U4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1201667_2 67281.JNZZ01000001_gene2060 1.63e-07 52.0 2BEQ6@1|root,328FS@2|Bacteria,2HE8N@201174|Actinobacteria 201174|Actinobacteria Q Phosphopantetheine attachment site - - - - - - - - - - - - PP-binding k59_1462763_2 247633.GP2143_01710 1.07e-17 85.1 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria 1236|Gammaproteobacteria G COG2211 Na melibiose symporter and related transporters - - - - - - - - - - - - MFS_2 k59_1044882_2 633697.EubceDRAFT1_1783 1.6e-10 60.8 COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,249VK@186801|Clostridia,25VA3@186806|Eubacteriaceae 186801|Clostridia J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_365919_2 439235.Dalk_1448 2.99e-36 137.0 COG0451@1|root,COG0451@2|Bacteria,1N8PG@1224|Proteobacteria,42UM2@68525|delta/epsilon subdivisions,2WR61@28221|Deltaproteobacteria 28221|Deltaproteobacteria GM PFAM NAD dependent epimerase dehydratase family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_1097129_2 765910.MARPU_11570 1.27e-74 232.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1WWPK@135613|Chromatiales 135613|Chromatiales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_52489_1 1192034.CAP_2431 4.74e-51 180.0 COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,42MZZ@68525|delta/epsilon subdivisions,2WIQI@28221|Deltaproteobacteria 28221|Deltaproteobacteria H MoeA domain protein domain I and II - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1253825_1 452662.SJA_C1-32920 1.68e-06 51.2 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,2TSQM@28211|Alphaproteobacteria,2K0ID@204457|Sphingomonadales 204457|Sphingomonadales J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides rnd - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_1253825_2 330214.NIDE2444 4.16e-34 123.0 COG0484@1|root,COG0484@2|Bacteria 2|Bacteria O heat shock protein binding cbpA GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363 - ko:K05516,ko:K05801,ko:K18481 - M00670 - - ko00000,ko00002,ko02000,ko03036,ko03110 3.A.1.27.4,3.A.1.27.5 - - DnaJ,DnaJ_C k59_835981_1 648885.KB316282_gene1026 3.83e-25 108.0 COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,1JSET@119045|Methylobacteriaceae 28211|Alphaproteobacteria G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2,5.3.1.9 ko:K01810,ko:K13810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00004,M00007,M00114 R01827,R02739,R02740,R03321 RC00376,RC00439,RC00563,RC00604 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI,TAL_FSA k59_1410538_3 268746.Q58MG0_BPPRM 2.44e-68 221.0 4QDUC@10239|Viruses,4QV7K@35237|dsDNA viruses no RNA stage,4QR22@28883|Caudovirales,4QJ6D@10662|Myoviridae 10662|Myoviridae S transferase activity - - - - - - - - - - - - - k59_52510_1 1163408.UU9_02873 5.43e-53 170.0 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1X6WU@135614|Xanthomonadales 135614|Xanthomonadales P protein affecting Mg2 Co2 transport apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_52510_2 312309.VF_2555 5.96e-23 99.4 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1XTCR@135623|Vibrionales 135623|Vibrionales O ATPase with chaperone activity comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_522560_2 1123253.AUBD01000009_gene2216 1.52e-12 63.9 COG2841@1|root,COG2841@2|Bacteria,1QB8P@1224|Proteobacteria,1T6SZ@1236|Gammaproteobacteria,1X83B@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF465) uptF - - - - - - - - - - - DUF465 k59_992708_1 298655.KI912266_gene4258 2.27e-98 301.0 COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_940456_1 1123368.AUIS01000014_gene2294 4.83e-117 352.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,2NBZH@225057|Acidithiobacillales 225057|Acidithiobacillales S Putative modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_313617_1 331678.Cphamn1_2124 4e-40 145.0 COG0589@1|root,COG0589@2|Bacteria,1FF22@1090|Chlorobi 1090|Chlorobi T response to stress - - - - - - - - - - - - - k59_313617_2 580332.Slit_1196 9.97e-84 271.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2VJ54@28216|Betaproteobacteria 28216|Betaproteobacteria O Belongs to the peptidase S16 family - - - - - - - - - - - - AAA_32,Lon_C k59_105367_1 744980.TRICHSKD4_3113 1.68e-60 198.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria 28211|Alphaproteobacteria O COG0330 Membrane protease subunits stomatin prohibitin homologs qmcA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Band_7,Band_7_C k59_105367_2 1249634.D781_1076 1.36e-09 57.4 COG1585@1|root,COG1585@2|Bacteria,1N241@1224|Proteobacteria,1S5W4@1236|Gammaproteobacteria,40370@613|Serratia 1236|Gammaproteobacteria OU membrane ybbJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07340 - - - - ko00000 - - - NfeD k59_1515503_1 935557.ATYB01000009_gene678 1.41e-37 144.0 COG2909@1|root,COG2909@2|Bacteria,1NU87@1224|Proteobacteria,2UR1Q@28211|Alphaproteobacteria,4BHUQ@82115|Rhizobiaceae 28211|Alphaproteobacteria K AAA ATPase domain - - - - - - - - - - - - AAA_16,GerE k59_209922_1 926566.Terro_0060 5.44e-16 83.2 COG1228@1|root,COG1228@2|Bacteria,3Y4IP@57723|Acidobacteria,2JMQC@204432|Acidobacteriia 204432|Acidobacteriia Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_53509_1 861299.J421_1568 1.35e-59 189.0 COG3663@1|root,COG3663@2|Bacteria,1ZTNU@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Uracil DNA glycosylase superfamily - - 3.2.2.28 ko:K03649 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1098013_1 870187.Thini_0837 8.65e-118 349.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,4606I@72273|Thiotrichales 72273|Thiotrichales J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_523356_1 349124.Hhal_1727 2.82e-73 229.0 COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,1RPYF@1236|Gammaproteobacteria,1WX5H@135613|Chromatiales 135613|Chromatiales P pfam abc-3 - - - ko:K09816 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_523356_2 371042.NG99_25265 2.88e-14 71.2 COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,1RPJT@1236|Gammaproteobacteria,3X5FF@551|Erwinia 1236|Gammaproteobacteria P Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system znuC GO:0000041,GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005385,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008144,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0072509,GO:0072511,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363 - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - iSFV_1184.SFV_1859,iSF_1195.SF1867,iSFxv_1172.SFxv_2092,iS_1188.S1934 ABC_tran k59_105377_1 1280941.HY2_01675 4.48e-30 114.0 COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,2TS67@28211|Alphaproteobacteria,43WZQ@69657|Hyphomonadaceae 28211|Alphaproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 k59_1463653_1 1122947.FR7_1761 3.58e-21 93.2 COG0132@1|root,COG0132@2|Bacteria,1UYA3@1239|Firmicutes,4H461@909932|Negativicutes 909932|Negativicutes H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD - 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - - AAA_26 k59_53529_1 1392540.P256_00073 7.35e-07 52.8 2EP09@1|root,33GM3@2|Bacteria,1QU6R@1224|Proteobacteria,1T1P1@1236|Gammaproteobacteria,3NKJI@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_993372_1 397945.Aave_0872 3.21e-36 138.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4A9V8@80864|Comamonadaceae 28216|Betaproteobacteria T response regulator yfhA - - ko:K07715 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1359245_1 748658.KB907316_gene421 7.86e-88 268.0 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,1RN90@1236|Gammaproteobacteria,1WW7R@135613|Chromatiales 135613|Chromatiales NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue - - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_1202688_1 1121374.KB891579_gene1735 4.04e-05 45.8 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria 1236|Gammaproteobacteria EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_1202688_2 1333998.M2A_2612 6.61e-57 192.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,4BPTY@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C FAD linked oxidases, C-terminal domain MA20_42035 GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006089,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016053,GO:0016491,GO:0016614,GO:0016898,GO:0019249,GO:0019516,GO:0019752,GO:0022900,GO:0022904,GO:0030447,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046394,GO:0048037,GO:0050660,GO:0050662,GO:0051990,GO:0055114,GO:0071704,GO:0071949,GO:0072330,GO:0097159,GO:0099615,GO:1901265,GO:1901363,GO:1901576,GO:1901615,GO:1901617 1.1.2.4 ko:K00102 ko00620,map00620 - R00197 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_523366_2 665571.STHERM_c22000 0.00028 46.6 COG2204@1|root,COG2204@2|Bacteria,2J63G@203691|Spirochaetes 203691|Spirochaetes T Regulatory protein - - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_470964_1 1385513.N780_10045 5.18e-21 98.2 COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,4HAIP@91061|Bacilli,2Y9SR@289201|Pontibacillus 91061|Bacilli E Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_53543_1 1122135.KB893146_gene1493 1.71e-85 274.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TSUW@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase fadE - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_575637_1 349521.HCH_03648 3.24e-41 151.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1XMXM@135619|Oceanospirillales 135619|Oceanospirillales J Elongation factor G, domain IV - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_575637_2 522306.CAP2UW1_1971 1.09e-49 164.0 COG3749@1|root,COG3749@2|Bacteria,1RJR9@1224|Proteobacteria,2VSQB@28216|Betaproteobacteria,1KQ40@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF934) - - - - - - - - - - - - DUF934 k59_575637_3 322710.Avin_27520 3.99e-21 93.6 COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,1RMFH@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate cysI - 1.8.1.2 ko:K00381 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_1202697_1 330214.NIDE0306 6.43e-15 75.9 COG4783@1|root,COG4783@2|Bacteria,3J19Q@40117|Nitrospirae 40117|Nitrospirae S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Peptidase_M48 k59_1202697_2 1094466.KQS_00165 2.35e-07 53.5 COG4269@1|root,COG4269@2|Bacteria,4NI7F@976|Bacteroidetes,1I85H@117743|Flavobacteriia,2NTM3@237|Flavobacterium 976|Bacteroidetes S Bacterial protein of unknown function (DUF898) - - - - - - - - - - - - DUF898 k59_1098058_2 266264.Rmet_0419 2.43e-107 314.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VJ4C@28216|Betaproteobacteria,1K14P@119060|Burkholderiaceae 28216|Betaproteobacteria S phospholipid-binding protein bbsI - - ko:K06910 - - - - ko00000 - - - PBP k59_836888_1 156578.ATW7_13773 5.82e-15 73.6 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the ClpA ClpB family clpA GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_836888_2 395493.BegalDRAFT_1678 1.41e-53 169.0 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,1S8Z7@1236|Gammaproteobacteria,46127@72273|Thiotrichales 72273|Thiotrichales S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_1411232_1 631362.Thi970DRAFT_02959 3.75e-33 131.0 COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,1MXJQ@1224|Proteobacteria,1RQIY@1236|Gammaproteobacteria,1WXGP@135613|Chromatiales 135613|Chromatiales KT PFAM Stage II sporulation E family protein - - 3.1.3.3 ko:K01079,ko:K07315 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03021 - - - GAF,HAMP,SpoIIE,dCache_1 k59_366820_1 595537.Varpa_3006 5.22e-54 178.0 COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,2WFQP@28216|Betaproteobacteria,4ABHJ@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM Conserved TM helix repeat-containing protein - - - - - - - - - - - - TM_helix k59_1254862_1 519989.ECTPHS_03954 1.64e-68 218.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1WWVS@135613|Chromatiales 135613|Chromatiales E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_889206_1 1502851.FG93_05149 2.8e-24 103.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,3JTTR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_889206_2 69279.BG36_09600 2.55e-145 415.0 COG1173@1|root,COG1173@2|Bacteria,1MVHY@1224|Proteobacteria,2TQVQ@28211|Alphaproteobacteria,43JAB@69277|Phyllobacteriaceae 28211|Alphaproteobacteria EP Binding-protein-dependent transport system inner membrane component MA20_19550 - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_889206_3 69279.BG36_09605 1.93e-41 145.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TQJC@28211|Alphaproteobacteria,43J58@69277|Phyllobacteriaceae 28211|Alphaproteobacteria EP Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1098067_1 643562.Daes_0035 2.02e-13 78.6 COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,42MWR@68525|delta/epsilon subdivisions,2WPAV@28221|Deltaproteobacteria,2MBJF@213115|Desulfovibrionales 28221|Deltaproteobacteria C TIGRFAM SagB-type dehydrogenase - - - - - - - - - - - - Nitroreductase k59_941268_2 1577887.JSYG01000039_gene2289 2.85e-24 103.0 COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,1RMZB@1236|Gammaproteobacteria,2JD0Y@204037|Dickeya 1236|Gammaproteobacteria IQ PFAM short-chain dehydrogenase reductase SDR kduD - 1.1.1.127 ko:K00065 ko00040,map00040 - R01542 RC00089 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_418988_1 237368.SCABRO_00607 1.08e-11 69.3 COG0707@1|root,COG0707@2|Bacteria 2|Bacteria M undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity - - - - - - - - - - - - Glyco_tran_28_C,Glyco_trans_1_3 k59_575663_1 1167006.UWK_03499 5.74e-83 253.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2WJ1I@28221|Deltaproteobacteria,2MIE0@213118|Desulfobacterales 28221|Deltaproteobacteria K transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Transcrip_reg k59_1254881_3 316055.RPE_0831 3.91e-27 115.0 COG3303@1|root,COG3303@2|Bacteria,1QXZC@1224|Proteobacteria,2TRV1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome c3 - - - - - - - - - - - - Paired_CXXCH_1 k59_366842_1 1123487.KB892838_gene3864 4.05e-21 95.5 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,2KV9G@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M k59_1202738_1 765869.BDW_08595 3.58e-109 335.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2MSUZ@213481|Bdellovibrionales,2WJ20@28221|Deltaproteobacteria 213481|Bdellovibrionales L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1359301_2 1131553.JIBI01000005_gene2227 8.55e-40 147.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,371SD@32003|Nitrosomonadales 28216|Betaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1211088_1 1123247.AUIJ01000025_gene752 4.65e-93 296.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Acetyl propionyl-CoA carboxylase alpha subunit - - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_321604_1 1123354.AUDR01000014_gene867 7.29e-20 86.7 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2VRGK@28216|Betaproteobacteria,1KRQI@119069|Hydrogenophilales 119069|Hydrogenophilales K Transcriptional regulator - - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_321604_2 751994.AGIG01000028_gene2025 3.61e-19 87.4 COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R2NF@1224|Proteobacteria 1224|Proteobacteria K PFAM regulatory protein, MerR - - - ko:K22491 - - - - ko00000,ko03000 - - - B12-binding,B12-binding_2,MerR_1 k59_1417863_1 2342.SOPEG_2076 7.91e-05 43.5 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - ko:K03925 - - - - ko00000 - - - MraZ k59_1365731_1 471854.Dfer_0171 1.22e-22 103.0 COG0745@1|root,COG2198@1|root,COG5002@1|root,COG5278@1|root,COG0745@2|Bacteria,COG2198@2|Bacteria,COG5002@2|Bacteria,COG5278@2|Bacteria,4P0IA@976|Bacteroidetes,47Y5H@768503|Cytophagia 976|Bacteroidetes T CHASE3 domain - - - - - - - - - - - - CHASE3,Guanylate_cyc,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,TPR_12 k59_477518_1 95619.PM1_0201225 2.98e-17 87.0 COG2120@1|root,COG2120@2|Bacteria,1RBZY@1224|Proteobacteria,1S5RR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L k59_1211099_1 247633.GP2143_12246 5.66e-99 299.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria 1224|Proteobacteria I acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1574917_3 1589733.A0A0C5AEF2_9CAUD 3.17e-08 51.6 4QAQV@10239|Viruses,4QPCB@28883|Caudovirales,4QHY7@10662|Myoviridae 10662|Myoviridae S protein disulfide oxidoreductase activity - - - - - - - - - - - - - k59_844243_1 436308.Nmar_0805 2.54e-78 234.0 COG0091@1|root,arCOG04098@2157|Archaea,41SJ4@651137|Thaumarchaeota 651137|Thaumarchaeota J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rpl22 - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_426355_1 556267.HWAG_00284 1.17e-25 105.0 COG0863@1|root,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_896634_1 279714.FuraDRAFT_2158 4.65e-10 61.6 COG3791@1|root,COG3791@2|Bacteria,1RFBP@1224|Proteobacteria,2VQN8@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM glutathione-dependent formaldehyde-activating GFA - - - - - - - - - - - - GFA k59_689302_1 1219065.VPR01S_04_01650 3.55e-25 107.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1XT0R@135623|Vibrionales 135623|Vibrionales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C k59_1264278_1 511062.GU3_02170 1.54e-32 130.0 COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1Y43V@135624|Aeromonadales 135624|Aeromonadales NU general secretion pathway protein D exeD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_1264278_3 472759.Nhal_3650 4.68e-08 55.1 2DKUH@1|root,30CV1@2|Bacteria,1NCRM@1224|Proteobacteria,1SBMH@1236|Gammaproteobacteria,1X28Z@135613|Chromatiales 135613|Chromatiales U Type II secretion system (T2SS), protein M subtype b - - - ko:K02462 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSM_b k59_794285_1 1265313.HRUBRA_02711 4.97e-19 91.3 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014,ko:K16087 - - - - ko00000,ko02000 1.B.14,1.B.14.2 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_896640_2 313612.L8106_07796 2.52e-26 109.0 COG0534@1|root,COG0534@2|Bacteria,1G2M4@1117|Cyanobacteria,1H8IY@1150|Oscillatoriales 1117|Cyanobacteria V Mate efflux family protein - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_478563_1 1323361.JPOC01000015_gene3746 1.12e-14 75.5 COG1878@1|root,COG1878@2|Bacteria,2GNFV@201174|Actinobacteria,4FV3Y@85025|Nocardiaceae 201174|Actinobacteria S Putative cyclase - - - - - - - - - - - - Cyclase k59_478563_2 1122962.AULH01000006_gene3271 1.47e-10 65.5 COG2378@1|root,COG2378@2|Bacteria,1MXS8@1224|Proteobacteria,2TT5H@28211|Alphaproteobacteria,36XZY@31993|Methylocystaceae 28211|Alphaproteobacteria K WYL domain - - - - - - - - - - - - GST_C_2,GST_N,HTH_11,WYL k59_1366576_1 105420.BBPO01000002_gene7516 3.33e-58 191.0 COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,2NHN2@228398|Streptacidiphilus 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_426366_1 1123073.KB899241_gene2226 1.66e-35 137.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1X333@135614|Xanthomonadales 135614|Xanthomonadales I converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_1472333_1 686340.Metal_0403 1.12e-78 244.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,1XDX7@135618|Methylococcales 135618|Methylococcales J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1472333_2 1260251.SPISAL_05565 3.53e-05 46.2 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1WVXY@135613|Chromatiales 135613|Chromatiales J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_1366578_1 887062.HGR_12812 5.67e-39 142.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2VHJY@28216|Betaproteobacteria,4A9T1@80864|Comamonadaceae 28216|Betaproteobacteria I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_1366578_2 634499.EpC_08750 1.24e-09 58.2 COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,1T63B@1236|Gammaproteobacteria,3X6B2@551|Erwinia 1236|Gammaproteobacteria M Phosphatidate cytidylyltransferase cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_582816_1 394.NGR_c15720 1.68e-49 166.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,4BBGT@82115|Rhizobiaceae 28211|Alphaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_112205_1 436308.Nmar_0274 1.15e-28 108.0 COG5016@1|root,arCOG02095@2157|Archaea,41SKA@651137|Thaumarchaeota 651137|Thaumarchaeota C Biotin-requiring enzyme - - - ko:K18605 ko00720,ko01120,map00720,map01120 - R00742,R01859 RC00040,RC00097,RC00367,RC00609 ko00000,ko00001 - - - Biotin_lipoyl k59_112205_2 1229909.NSED_01275 5.94e-63 195.0 COG1225@1|root,arCOG00310@2157|Archaea,41SKG@651137|Thaumarchaeota 651137|Thaumarchaeota O Redoxin - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_794300_2 861299.J421_4071 6e-13 68.6 COG1574@1|root,COG1574@2|Bacteria,1ZTC9@142182|Gemmatimonadetes 2|Bacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_896655_1 1121904.ARBP01000079_gene6053 1.3e-31 129.0 COG3292@1|root,COG4191@1|root,COG3292@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,HAMP,HATPase_c,HisKA,PAS,PAS_9,Reg_prop,TPR_12,Y_Y_Y k59_1264302_1 323261.Noc_1433 1.6e-83 258.0 COG0508@1|root,COG0508@2|Bacteria,1MVDC@1224|Proteobacteria,1RQ9Y@1236|Gammaproteobacteria,1WZYE@135613|Chromatiales 135613|Chromatiales C 2-oxoacid dehydrogenases acyltransferase (catalytic domain) - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1264302_2 1122132.AQYH01000019_gene409 2.49e-12 68.2 COG0697@1|root,COG0697@2|Bacteria,1MXPW@1224|Proteobacteria,2VFWJ@28211|Alphaproteobacteria,4BNE4@82115|Rhizobiaceae 28211|Alphaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_637553_1 483219.LILAB_27190 5.68e-36 131.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,42RAD@68525|delta/epsilon subdivisions,2X5RN@28221|Deltaproteobacteria,2Z372@29|Myxococcales 28221|Deltaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_637553_2 710686.Mycsm_02305 1.36e-36 130.0 COG5517@1|root,COG5517@2|Bacteria,2IG3J@201174|Actinobacteria,238JG@1762|Mycobacteriaceae 201174|Actinobacteria Q SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_62998_1 1499967.BAYZ01000115_gene2932 1.84e-42 158.0 COG0112@1|root,COG0404@1|root,COG0112@2|Bacteria,COG0404@2|Bacteria,2NP28@2323|unclassified Bacteria 2|Bacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism gcvT GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.1,2.1.2.10,2.2.1.8 ko:K00600,ko:K00605,ko:K18847 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R01221,R02300,R04125,R09099 RC00022,RC00069,RC00112,RC00183,RC01583,RC02834,RC02958 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C,SHMT k59_689327_1 1156919.QWC_30656 1.73e-62 210.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VHCF@28216|Betaproteobacteria,3T5Y4@506|Alcaligenaceae 28216|Betaproteobacteria J Belongs to the amidase family tms - - ko:K21801 ko00380,ko01100,map00380,map01100 - - - ko00000,ko00001,ko01000 - - - Amidase k59_1314054_1 1038860.AXAP01000015_gene2094 6.03e-95 298.0 COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,2TU2E@28211|Alphaproteobacteria,3JRH2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G aldehyde-lyase activity xfp - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_269740_1 1122605.KB893625_gene1682 0.000963 47.4 COG3119@1|root,COG3119@2|Bacteria,4NEBN@976|Bacteroidetes,1IQ13@117747|Sphingobacteriia 976|Bacteroidetes P PFAM sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_1000175_1 1042375.AFPL01000038_gene1504 1.24e-133 387.0 COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,1RQ0A@1236|Gammaproteobacteria,4687B@72275|Alteromonadaceae 1236|Gammaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K15552 ko00920,ko02010,map00920,map02010 M00435 - - ko00000,ko00001,ko00002,ko02000 3.A.1.17.1,3.A.1.17.4 - - BPD_transp_1 k59_1053309_1 1196028.ALEF01000037_gene829 5.77e-49 174.0 COG0075@1|root,COG3916@1|root,COG0075@2|Bacteria,COG3916@2|Bacteria,1TR3I@1239|Firmicutes,4HA6W@91061|Bacilli 91061|Bacilli E Aminotransferase class-V - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_5,Acetyltransf_9,Aminotran_5 k59_794326_1 1283283.ATXA01000014_gene3549 2.65e-13 74.3 COG1804@1|root,COG1804@2|Bacteria,2GMGE@201174|Actinobacteria 201174|Actinobacteria C acyl-CoA transferases carnitine dehydratase - - - - - - - - - - - - CoA_transf_3 k59_896675_1 105559.Nwat_1338 2.58e-81 253.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1WX22@135613|Chromatiales 135613|Chromatiales IQ Belongs to the beta-ketoacyl-ACP synthases family - - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1574968_1 401526.TcarDRAFT_1875 1.97e-29 120.0 COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,4H2KV@909932|Negativicutes 909932|Negativicutes E ABC transporter substrate-binding protein - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1264327_2 1122611.KB903974_gene3107 1.05e-27 109.0 COG4424@1|root,COG4424@2|Bacteria,2HETZ@201174|Actinobacteria,4EH26@85012|Streptosporangiales 201174|Actinobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_1,Sulfotransfer_3 k59_1105641_1 290397.Adeh_3405 2.06e-75 253.0 COG4581@1|root,COG4581@2|Bacteria,1QUPR@1224|Proteobacteria,42NSH@68525|delta/epsilon subdivisions,2WKD7@28221|Deltaproteobacteria,2YUGZ@29|Myxococcales 28221|Deltaproteobacteria L DEAD DEAH box helicase - - - - - - - - - - - - DEAD,DSHCT,DUF3516,Helicase_C k59_1264330_2 436308.Nmar_0684 2.08e-95 287.0 COG1163@1|root,arCOG00358@2157|Archaea,41SAD@651137|Thaumarchaeota 651137|Thaumarchaeota S small GTP-binding protein - - - ko:K06944 - - - - ko00000 - - - MMR_HSR1,MMR_HSR1_Xtn,TGS k59_1053322_1 331869.BAL199_09625 1.63e-25 100.0 2CUA5@1|root,32SUX@2|Bacteria,1RJP0@1224|Proteobacteria,2U9T0@28211|Alphaproteobacteria 28211|Alphaproteobacteria S complex i intermediate-associated protein 30 - - - - - - - - - - - - CIA30 k59_1053322_2 366602.Caul_0177 6.26e-45 150.0 COG3476@1|root,COG3476@2|Bacteria,1MZC1@1224|Proteobacteria,2UBYB@28211|Alphaproteobacteria,2KHAG@204458|Caulobacterales 204458|Caulobacterales T TspO MBR family protein - - - ko:K05770 ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166 - - - ko00000,ko00001,ko02000 9.A.24 - - TspO_MBR k59_1472387_1 314287.GB2207_05292 2.68e-23 98.2 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1J4FQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EGP major facilitator superfamily yajR GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - - - - - - - - - - MFS_1,Sugar_tr k59_1105645_1 1121033.AUCF01000001_gene2206 1.02e-97 293.0 COG2267@1|root,COG2267@2|Bacteria,1NTH9@1224|Proteobacteria,2TWFW@28211|Alphaproteobacteria,2JQWG@204441|Rhodospirillales 204441|Rhodospirillales I hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_478620_2 871963.Desdi_0891 8.55e-11 62.4 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UIEA@1239|Firmicutes,25EJM@186801|Clostridia 186801|Clostridia GT pyruvate phosphate dikinase, PEP ppdK - 2.7.9.1,2.7.9.2 ko:K01006,ko:K01007 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173,M00374 R00199,R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_794348_2 339671.Asuc_1952 7.6e-55 184.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1Y6UC@135625|Pasteurellales 135625|Pasteurellales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_1366620_1 1123024.AUII01000006_gene4635 4.74e-34 128.0 2DN8B@1|root,32W2U@2|Bacteria,2ISPU@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_426415_1 1304275.C41B8_08520 3.25e-75 237.0 COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,1RPUC@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG2230 Cyclopropane fatty acid synthase and related methyltransferases cfa - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_1053334_2 1219080.VEZ01S_59_00130 9e-08 52.0 COG0695@1|root,COG0695@2|Bacteria,1NH8Z@1224|Proteobacteria,1SGAT@1236|Gammaproteobacteria,1XYWH@135623|Vibrionales 135623|Vibrionales O COG0526 Thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - DUF836 k59_1264348_1 1137268.AZXF01000011_gene3749 1.08e-13 75.9 COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria,4EGNP@85012|Streptosporangiales 201174|Actinobacteria S Pup-ligase protein dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 ko:K20814 - - - - ko00000,ko01000,ko03051 - - - Pup_ligase k59_1314083_1 2340.JV46_04780 6.23e-54 182.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1J5IY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG0577 ABC-type antimicrobial peptide transport system, permease component VP1997 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1314083_2 472759.Nhal_3356 1.86e-26 107.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1WXP0@135613|Chromatiales 135613|Chromatiales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_689369_1 483219.LILAB_18040 5.95e-56 185.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,42MES@68525|delta/epsilon subdivisions,2WIQK@28221|Deltaproteobacteria,2YU2N@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_844322_1 395493.BegalDRAFT_0308 2.02e-174 496.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,1T1GA@1236|Gammaproteobacteria,4602W@72273|Thiotrichales 72273|Thiotrichales E Cys/Met metabolism PLP-dependent enzyme - - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_112262_1 62928.azo0939 1.93e-31 126.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,2KUXR@206389|Rhodocyclales 206389|Rhodocyclales J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_1574999_1 1242864.D187_001443 1.3e-26 115.0 COG0421@1|root,COG0457@1|root,COG0421@2|Bacteria,COG0457@2|Bacteria,1QXA2@1224|Proteobacteria,43C3D@68525|delta/epsilon subdivisions,2WUH2@28221|Deltaproteobacteria,2YYH4@29|Myxococcales 28221|Deltaproteobacteria E Spermine/spermidine synthase domain - - - - - - - - - - - - Spermine_synth k59_63061_1 443143.GM18_4036 1.14e-53 191.0 COG1360@1|root,COG2885@1|root,COG1360@2|Bacteria,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales 28221|Deltaproteobacteria M OmpA family - - - - - - - - - - - - OmpA k59_948116_1 926549.KI421517_gene2275 1.3e-88 285.0 COG5009@1|root,COG5009@2|Bacteria,4NECJ@976|Bacteroidetes,47K6R@768503|Cytophagia 976|Bacteroidetes M Penicillin binding protein transpeptidase pbpB - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_948116_2 1123057.P872_07045 1.67e-26 108.0 COG0322@1|root,COG0322@2|Bacteria,4NE61@976|Bacteroidetes,47JXP@768503|Cytophagia 976|Bacteroidetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_1264376_1 290512.Paes_0606 2.53e-111 330.0 COG0189@1|root,COG0189@2|Bacteria,1FEIE@1090|Chlorobi 1090|Chlorobi H Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_374233_1 436308.Nmar_1509 2.76e-125 369.0 COG0608@1|root,arCOG00427@2157|Archaea,41SZF@651137|Thaumarchaeota 651137|Thaumarchaeota L DHHA1 domain - - - ko:K07463 - - - - ko00000 - - - DHHA1 k59_1000239_2 436308.Nmar_1762 2.22e-44 145.0 COG1522@1|root,arCOG01117@2157|Archaea,41T58@651137|Thaumarchaeota 651137|Thaumarchaeota K Lrp/AsnC ligand binding domain - - - - - - - - - - - - AsnC_trans_reg k59_1053356_1 272844.PAB1943 4.31e-20 92.0 COG0430@1|root,arCOG04125@2157|Archaea,2XT7I@28890|Euryarchaeota,2438J@183968|Thermococci 183968|Thermococci J Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP rtcA GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098 6.5.1.5 ko:K18105 - - - - ko00000,ko01000 - - - RTC,RTC_insert k59_582898_1 1382306.JNIM01000001_gene1964 1.56e-41 150.0 COG0520@1|root,COG0520@2|Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine ycbU - - - - - - - - - - - Aminotran_5 k59_1212253_1 765869.BDW_02060 2.69e-27 118.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2MTMI@213481|Bdellovibrionales,2WMCQ@28221|Deltaproteobacteria 213481|Bdellovibrionales T Response regulator receiver - - - - - - - - - - - - AAA_16,GAF,HAMP,HATPase_c,HisKA,PAS_9,Pkinase,Response_reg,dCache_1 k59_217447_2 945713.IALB_2893 3.94e-95 291.0 COG0719@1|root,COG0719@2|Bacteria 2|Bacteria O iron-sulfur cluster assembly sufB GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840 - ko:K07033,ko:K09014 - - - - ko00000 - - iAPECO1_1312.APECO1_760,iECH74115_1262.ECH74115_2397,iECSF_1327.ECSF_1543,iECSP_1301.ECSP_2250,iUTI89_1310.UTI89_C1875,ic_1306.c2078 UPF0051 k59_1418788_1 1537915.JU57_05545 4.29e-09 67.4 COG1195@1|root,COG3210@1|root,COG1195@2|Bacteria,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,43DGB@68525|delta/epsilon subdivisions,2YTII@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria LU Calx-beta domain - - - - - - - - - - - - Calx-beta k59_374242_1 196367.JNFG01000202_gene2637 7.94e-10 58.5 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2VI6W@28216|Betaproteobacteria,1K1EZ@119060|Burkholderiaceae 28216|Betaproteobacteria C Electron transfer flavoprotein etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_850291_3 1335230.S5WKS5_9CAUD 2.43e-17 79.7 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales,4QHXI@10662|Myoviridae 10662|Myoviridae S hydrolase activity - - - - - - - - - - - - - k59_432299_1 589865.DaAHT2_0141 5.21e-68 231.0 COG1554@1|root,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,42Q4Z@68525|delta/epsilon subdivisions,2WM28@28221|Deltaproteobacteria,2MN69@213118|Desulfobacterales 28221|Deltaproteobacteria G Glycosyl hydrolase family 65, N-terminal domain - - - - - - - - - - - - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Hydrolase k59_1426743_1 290397.Adeh_0928 7.06e-92 286.0 COG0003@1|root,COG0003@2|Bacteria,1PMWP@1224|Proteobacteria,42RUR@68525|delta/epsilon subdivisions,2WNEE@28221|Deltaproteobacteria,2YUU4@29|Myxococcales 28221|Deltaproteobacteria D AAA domain agmR - - - - - - - - - - - ArsA_ATPase k59_1426743_2 439235.Dalk_2943 3.88e-28 115.0 COG0003@1|root,COG0003@2|Bacteria,1NA7C@1224|Proteobacteria,42V2J@68525|delta/epsilon subdivisions,2WS25@28221|Deltaproteobacteria 28221|Deltaproteobacteria P COG0003 Oxyanion-translocating ATPase - - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase k59_1524582_1 1229909.NSED_00700 2.45e-26 105.0 COG2133@1|root,arCOG02796@2157|Archaea,41S7F@651137|Thaumarchaeota 651137|Thaumarchaeota G Glucose sorbosone - - - - - - - - - - - - GSDH k59_1524582_2 1229909.NSED_00705 8.03e-56 185.0 COG1257@1|root,arCOG04260@2157|Archaea,41SAU@651137|Thaumarchaeota 651137|Thaumarchaeota I Belongs to the HMG-CoA reductase family - - 1.1.1.88 ko:K00054 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R02081 RC00004,RC00644 ko00000,ko00001,ko01000 - - - HMG-CoA_red k59_1272409_1 211165.AJLN01000063_gene3774 1.86e-53 179.0 COG0398@1|root,COG0398@2|Bacteria,1G3PG@1117|Cyanobacteria,1JJR5@1189|Stigonemataceae 1117|Cyanobacteria S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_169192_1 1121094.KB894647_gene686 1.46e-73 236.0 COG0439@1|root,COG0439@2|Bacteria,4NFEQ@976|Bacteroidetes,2FMBN@200643|Bacteroidia,4ANDX@815|Bacteroidaceae 976|Bacteroidetes I Biotin carboxylase accC - 6.3.4.14,6.4.1.2,6.4.1.3 ko:K01961,ko:K01965 ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00373,M00376,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_1218363_1 1131553.JIBI01000001_gene1564 3.64e-133 389.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2VHBP@28216|Betaproteobacteria,371XV@32003|Nitrosomonadales 28216|Betaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_223548_1 1123514.KB905899_gene1989 5.31e-80 251.0 COG0531@1|root,COG0531@2|Bacteria,1PKIV@1224|Proteobacteria,1T9HU@1236|Gammaproteobacteria,461MJ@72273|Thiotrichales 72273|Thiotrichales E Amino acid permease - - - - - - - - - - - - AA_permease_2 k59_1006640_1 386043.lwe1363 1.66e-74 239.0 COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,4H9MX@91061|Bacilli,26JCI@186820|Listeriaceae 91061|Bacilli E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_1006640_2 1265505.ATUG01000003_gene297 9.37e-46 151.0 COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,42RS9@68525|delta/epsilon subdivisions,2WP93@28221|Deltaproteobacteria,2MJV4@213118|Desulfobacterales 28221|Deltaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H k59_119152_1 511062.GU3_01860 3.13e-41 147.0 COG0679@1|root,COG0679@2|Bacteria,1N1X9@1224|Proteobacteria,1RY7R@1236|Gammaproteobacteria 1236|Gammaproteobacteria S auxin efflux carrier - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_1372666_1 1167006.UWK_02822 2.62e-88 274.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MISJ@213118|Desulfobacterales 28221|Deltaproteobacteria J ribonuclease Rne Rng family cafA - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_850307_1 247639.MGP2080_10793 1.98e-61 213.0 COG1629@1|root,COG4772@1|root,COG1629@2|Bacteria,COG4772@2|Bacteria,1QTVF@1224|Proteobacteria,1RRPP@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport sftP - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_6825_1 1458357.BG58_11835 4.35e-95 289.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VMYW@28216|Betaproteobacteria,1K1RG@119060|Burkholderiaceae 28216|Betaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_381362_1 658187.LDG_8472 3.62e-27 108.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1JDJ4@118969|Legionellales 118969|Legionellales H Catalyzes the ferrous insertion into protoporphyrin IX hemH GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_381362_2 1163389.OOM_0755 2.28e-29 118.0 COG1183@1|root,COG1183@2|Bacteria,1NGCJ@1224|Proteobacteria,1S88D@1236|Gammaproteobacteria,462BR@72273|Thiotrichales 72273|Thiotrichales I Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP - - 2.7.8.24 ko:K01004 ko00564,ko01110,map00564,map01110 - R05794 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - - k59_223557_1 1127673.GLIP_4121 1.25e-42 152.0 COG0598@1|root,COG0598@2|Bacteria,1MW8W@1224|Proteobacteria,1RRTZ@1236|Gammaproteobacteria,464S0@72275|Alteromonadaceae 1236|Gammaproteobacteria P CorA-like Mg2+ transporter protein zntB GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - ko:K16074 - - - - ko00000,ko02000 1.A.35.4 - - CorA k59_71000_1 330214.NIDE1724 3.62e-85 270.0 COG5184@1|root,COG5184@2|Bacteria 2|Bacteria DZ guanyl-nucleotide exchange factor activity - - - - - - - - - - - - Big_5,Cadherin-like,DUF3494,Glug,TIG k59_71009_2 224324.aq_437 0.000223 43.9 COG1034@1|root,COG1034@2|Bacteria,2G40D@200783|Aquificae 200783|Aquificae C PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4,Molybdop_Fe4S4,NADH-G_4Fe-4S_3 k59_1480437_1 247490.KSU1_C1645 1.3e-49 177.0 COG0058@1|root,COG0058@2|Bacteria,2IY0J@203682|Planctomycetes 203682|Planctomycetes G COG0058 Glucan phosphorylase - - - - - - - - - - - - Phosphorylase,YHS k59_1272445_1 298655.KI912266_gene4423 8.04e-20 90.9 COG2072@1|root,COG2072@2|Bacteria,2GJEA@201174|Actinobacteria 201174|Actinobacteria P Flavoprotein involved in K transport - - 1.14.13.84 ko:K14520 ko00363,ko01100,ko01120,map00363,map01100,map01120 - R06892 RC01644 ko00000,ko00001,ko01000 - - - FMO-like,Pyr_redox_3 k59_1006661_1 411154.GFO_2845 8.32e-78 249.0 COG0388@1|root,COG0388@2|Bacteria,4PMRR@976|Bacteroidetes,1IJXU@117743|Flavobacteriia 976|Bacteroidetes S SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_119187_1 2340.JV46_19430 1.02e-12 68.6 COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,1RPHX@1236|Gammaproteobacteria,1J5QD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation ydiA GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030234,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0098772 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_119187_2 745277.GRAQ_01878 2.03e-17 81.3 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,3FETJ@34037|Rahnella 1236|Gammaproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008986,GO:0009058,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - iEcE24377_1341.EcE24377A_1919,iYL1228.KPN_02160 PEP-utilizers,PEP-utilizers_C,PPDK_N k59_954379_1 436308.Nmar_0053 3.22e-06 48.1 COG1679@1|root,arCOG04278@2157|Archaea,41SBC@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF521) - - - ko:K09123 - - - - ko00000 - - - DUF521 k59_954379_2 436308.Nmar_0054 2.31e-56 178.0 COG1786@1|root,arCOG04279@2157|Archaea,41SPA@651137|Thaumarchaeota 651137|Thaumarchaeota C Protein of unknown function DUF126 - - - ko:K09128 - - - - ko00000 - - - DUF126 k59_954379_3 1158318.ATXC01000001_gene1408 6.35e-27 103.0 COG2078@1|root,COG2078@2|Bacteria,2G44K@200783|Aquificae 200783|Aquificae S PFAM AMMECR1 domain protein - - - ko:K09141 - - - - ko00000 - - - AMMECR1 k59_1006666_1 380703.AHA_3255 4.72e-56 189.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1Y427@135624|Aeromonadales 135624|Aeromonadales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_1372692_1 42256.RradSPS_1041 9.19e-83 258.0 COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4CPM3@84995|Rubrobacteria 84995|Rubrobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_1634536_1 671143.DAMO_2489 4.63e-73 236.0 COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria 2|Bacteria NU Type II secretion system (T2SS), protein E, N-terminal domain xpsE GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_328629_1 1463921.JODF01000001_gene4087 6.47e-31 125.0 COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria 2|Bacteria I AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_589064_1 1162668.LFE_1897 3.79e-47 156.0 COG2259@1|root,COG2259@2|Bacteria,3J13I@40117|Nitrospirae 40117|Nitrospirae S Evidence 4 Homologs of previously reported genes of - - - ko:K15977 - - - - ko00000 - - - DoxX k59_589064_2 1265505.ATUG01000003_gene316 7.7e-93 288.0 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,42PC9@68525|delta/epsilon subdivisions,2WKA4@28221|Deltaproteobacteria,2MJ22@213118|Desulfobacterales 28221|Deltaproteobacteria F Na dependent nucleoside transporter - - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_1524609_1 498761.HM1_0395 3.2e-53 181.0 COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,25E7B@186801|Clostridia 186801|Clostridia H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1524609_2 1122135.KB893167_gene2397 2.09e-13 72.8 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TTAK@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_328631_1 671143.DAMO_1249 2.72e-96 306.0 COG1615@1|root,COG1615@2|Bacteria,2NQSF@2323|unclassified Bacteria 2|Bacteria S Uncharacterised protein family (UPF0182) - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K09118 - - - - ko00000 - - - UPF0182 k59_850345_1 428126.CLOSPI_01414 2.54e-28 113.0 COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,3VRBH@526524|Erysipelotrichia 526524|Erysipelotrichia IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_589067_1 1229909.NSED_03360 1.59e-17 80.5 COG4608@1|root,arCOG00184@2157|Archaea,41S9E@651137|Thaumarchaeota 651137|Thaumarchaeota E Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_589067_2 1229909.NSED_03365 1.54e-45 156.0 COG4301@1|root,arCOG06722@2157|Archaea,41SWR@651137|Thaumarchaeota 651137|Thaumarchaeota S Histidine-specific methyltransferase, SAM-dependent - - - - - - - - - - - - Methyltransf_33 k59_1581143_1 1232410.KI421418_gene2422 7.49e-88 270.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,43VZ4@69541|Desulfuromonadales 28221|Deltaproteobacteria O SelR domain msrA - 1.8.4.11,1.8.4.12 ko:K07305,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_1480464_1 1041522.MCOL_V225782 5.56e-100 296.0 2EX42@1|root,33QF2@2|Bacteria,2I9M3@201174|Actinobacteria,235US@1762|Mycobacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1006683_1 9031.ENSGALP00000002224 0.000115 45.8 COG0330@1|root,KOG4170@1|root,KOG2621@2759|Eukaryota,KOG4170@2759|Eukaryota,39R9A@33154|Opisthokonta,3B973@33208|Metazoa,3D364@33213|Bilateria,484AI@7711|Chordata,496D0@7742|Vertebrata,4GSMJ@8782|Aves 33208|Metazoa CI Stomatin-like protein 1 STOML1 GO:0002028,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0008104,GO:0008150,GO:0008200,GO:0009987,GO:0010033,GO:0010766,GO:0010959,GO:0016020,GO:0016247,GO:0016248,GO:0022898,GO:0023052,GO:0031410,GO:0031982,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033036,GO:0034097,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042221,GO:0042493,GO:0043226,GO:0043227,GO:0043229,GO:0043269,GO:0043271,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0048519,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051051,GO:0051179,GO:0051234,GO:0051716,GO:0060395,GO:0065007,GO:0065009,GO:0070887,GO:0071310,GO:0071345,GO:0071944,GO:0097708,GO:0098772,GO:0099106,GO:1901585,GO:1901586,GO:1902305,GO:1902306,GO:1904062,GO:1904063,GO:1990823,GO:1990830,GO:2000649,GO:2000650,GO:2001257,GO:2001258 - - - - - - - - - - Band_7,SCP2 k59_1006683_2 269799.Gmet_0918 2.16e-57 189.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,42M1J@68525|delta/epsilon subdivisions,2WIQR@28221|Deltaproteobacteria,43SBN@69541|Desulfuromonadales 28221|Deltaproteobacteria D TIGRFAM cell shape determining protein, MreB Mrl family mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_119216_1 1485544.JQKP01000001_gene1182 1.53e-40 141.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2VH29@28216|Betaproteobacteria,44V0H@713636|Nitrosomonadales 28216|Betaproteobacteria S ABC transporter lptB - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_275971_1 565045.NOR51B_328 2.61e-23 101.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,1RRHA@1236|Gammaproteobacteria 1236|Gammaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_1525135_2 1229909.NSED_06405 5.13e-90 278.0 COG0322@1|root,arCOG04753@2157|Archaea,41SX9@651137|Thaumarchaeota 651137|Thaumarchaeota L TIGRFAM excinuclease ABC, C subunit - - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,UVR,UvrC_HhH_N k59_1060428_1 523791.Kkor_1563 2.53e-66 223.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RS6N@1236|Gammaproteobacteria,1XNZ7@135619|Oceanospirillales 135619|Oceanospirillales I AMP-binding enzyme C-terminal domain - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1060428_2 395493.BegalDRAFT_1071 2.61e-08 55.1 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria 1236|Gammaproteobacteria M protein conserved in bacteria ycbB - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_1427797_1 1229909.NSED_00425 6.2e-30 122.0 COG0642@1|root,arCOG02358@2157|Archaea 2157|Archaea T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k59_1273499_2 1185653.A1A1_08549 5.23e-10 63.5 COG1960@1|root,COG1960@2|Bacteria,1TPVK@1239|Firmicutes,4HA7B@91061|Bacilli,26E0W@186818|Planococcaceae 91061|Bacilli I Acyl-CoA dehydrogenase, middle domain B4168_2380 - 1.3.99.32 ko:K16173 ko00362,ko01120,map00362,map01120 - R05579 RC00052 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_696289_1 517722.AEUE01000004_gene1107 3.03e-39 140.0 COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,2K2E1@204457|Sphingomonadales 204457|Sphingomonadales G Belongs to the HpcH HpaI aldolase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_1319609_1 436308.Nmar_0223 1.16e-105 311.0 COG0788@1|root,arCOG02826@2157|Archaea,41S78@651137|Thaumarchaeota 651137|Thaumarchaeota F Formyl transferase - - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT_6,Formyl_trans_N k59_1373434_1 391038.Bphy_5504 1.23e-54 193.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1K0FI@119060|Burkholderiaceae 28216|Betaproteobacteria V Efflux pump membrane transporter - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_589846_1 1380394.JADL01000012_gene856 4.34e-79 255.0 28JZQ@1|root,2Z9PN@2|Bacteria,1N2WN@1224|Proteobacteria,2U0QD@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1635581_1 272134.KB731324_gene5861 2.77e-35 125.0 COG0664@1|root,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding crp - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1373439_1 118166.JH976538_gene5132 8.98e-64 207.0 COG2801@1|root,COG2801@2|Bacteria,1G5RM@1117|Cyanobacteria,1HHPH@1150|Oscillatoriales 1117|Cyanobacteria L Integrase core domain - - - - - - - - - - - - HTH_23,HTH_32,rve k59_696303_1 994573.T472_0205260 8.94e-21 94.4 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,36DJS@31979|Clostridiaceae 186801|Clostridia H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_433318_1 498761.HM1_2046 1.74e-09 61.2 COG0297@1|root,COG1543@1|root,COG0297@2|Bacteria,COG1543@2|Bacteria,1TPFX@1239|Firmicutes,2498V@186801|Clostridia 186801|Clostridia M Belongs to the glycosyl hydrolase 57 family - - 2.4.1.18 ko:K16149 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000 - GH57 - DUF1957,Glyco_hydro_57,Glyco_transf_4,Glycos_transf_1 k59_903614_1 113395.AXAI01000014_gene220 1.11e-88 290.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_1525156_1 501479.ACNW01000121_gene3048 1.01e-05 48.9 COG1712@1|root,COG1712@2|Bacteria,1MX8S@1224|Proteobacteria,2TV48@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate nadX - 1.4.1.21 ko:K06989 ko00760,ko01100,map00760,map01100 - R07407,R07410 RC02566 ko00000,ko00001,ko01000 - - - DUF108,NAD_binding_3 k59_335551_1 296587.XP_002507566.1 3.86e-17 84.7 COG0169@1|root,KOG0692@2759|Eukaryota,37I1M@33090|Viridiplantae,34GPQ@3041|Chlorophyta 3041|Chlorophyta E Shikimate dehydrogenase substrate binding domain - - 1.1.1.25,4.2.1.10 ko:K13832 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413,R03084 RC00206,RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_I,Shikimate_DH,Shikimate_dh_N k59_335551_2 1485545.JQLW01000007_gene828 2.74e-37 129.0 COG1146@1|root,COG1146@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding fdxA GO:0001666,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0009628,GO:0036293,GO:0043207,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0070482,GO:0075136 - ko:K05524 - - - - ko00000 - - - DUF3470,Fer4 k59_335551_3 1235457.C404_17090 5.43e-22 86.3 COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,2VVW8@28216|Betaproteobacteria,1KA4N@119060|Burkholderiaceae 28216|Betaproteobacteria J Belongs to the bacterial ribosomal protein bL33 family rpmG - - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 k59_335551_4 1423807.BACO01000024_gene751 9.28e-17 76.6 COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,4HKH9@91061|Bacilli,3F6X5@33958|Lactobacillaceae 91061|Bacilli J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_1642856_1 709032.Sulku_1394 3.13e-06 58.2 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2YMQV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1588382_1 1267535.KB906767_gene4230 1.58e-30 122.0 COG0477@1|root,COG2814@2|Bacteria,3Y99X@57723|Acidobacteria,2JP6K@204432|Acidobacteriia 204432|Acidobacteriia EGP PFAM Major facilitator superfamily - - - - - - - - - - - - MFS_3 k59_1013856_1 991905.SL003B_2305 7.52e-67 229.0 COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2TW58@28211|Alphaproteobacteria,4BT7Z@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria V ABC-2 family transporter protein - - - ko:K13926 - - - - ko00000 - - - ABC2_membrane_3,ABC_tran k59_440402_1 313628.LNTAR_25155 5.18e-66 209.0 COG3568@1|root,COG3568@2|Bacteria 2|Bacteria N Endonuclease Exonuclease Phosphatase - - - - - - - - - - - - Big_2,CBM_4_9,Exo_endo_phos,F5_F8_type_C,FIVAR,Laminin_G_3,Lyase_8,Lyase_8_C,Lyase_8_N k59_440402_2 313628.LNTAR_25200 1.64e-36 131.0 COG0708@1|root,COG0708@2|Bacteria 2|Bacteria L double-stranded DNA 3'-5' exodeoxyribonuclease activity - - - - - - - - - - - - Exo_endo_phos,Laminin_G_3 k59_389748_1 349124.Hhal_0189 2.88e-16 83.6 COG1988@1|root,COG1988@2|Bacteria,1PCAC@1224|Proteobacteria,1RYI5@1236|Gammaproteobacteria,1X244@135613|Chromatiales 135613|Chromatiales S PFAM membrane-bound metal-dependent hydrolase - - - ko:K07038 - - - - ko00000 - - - YdjM k59_10158_1 706191.PANA_0461 6.28e-79 256.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,3VZJ2@53335|Pantoea 1236|Gammaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_596126_1 330214.NIDE3418 1.42e-17 82.4 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_596126_2 330214.NIDE3419 2.34e-60 199.0 COG1232@1|root,COG1232@2|Bacteria 2|Bacteria H protoporphyrinogen oxidase activity - - 5.4.99.9 ko:K01854 ko00052,ko00520,map00052,map00520 - R00505,R09009 RC00317,RC02396 ko00000,ko00001,ko01000 - - - Amino_oxidase,Glyco_trans_1_4,NAD_binding_8 k59_960980_1 477184.KYC_10056 1.46e-11 67.0 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,3T49R@506|Alcaligenaceae 28216|Betaproteobacteria O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE - - ko:K02197 - - - - ko00000 - - - CcmE k59_1226569_1 1133850.SHJG_2714 5.3e-27 112.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria 201174|Actinobacteria Q cytochrome p450 - - - - - - - - - - - - p450 k59_1529641_1 998088.B565_0950 4.22e-82 249.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,1Y3PB@135624|Aeromonadales 135624|Aeromonadales C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family - - 1.3.5.4 ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 k59_174887_1 1282876.BAOK01000001_gene3317 1.89e-58 195.0 COG0400@1|root,COG0400@2|Bacteria,1P51S@1224|Proteobacteria,2TT0Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PFAM phospholipase Carboxylesterase - - - ko:K06999 - - - - ko00000 - - - Abhydrolase_2 k59_1324225_1 436308.Nmar_0041 2.08e-83 255.0 COG0083@1|root,arCOG01027@2157|Archaea,41S89@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate thrB - 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_1118636_1 1132509.C447_11030 3.28e-15 80.5 COG3119@1|root,arCOG02785@2157|Archaea,2XUB1@28890|Euryarchaeota,23TRP@183963|Halobacteria 183963|Halobacteria P COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - Sulfatase k59_596137_1 56780.SYN_03159 5.34e-56 188.0 COG3547@1|root,COG3547@2|Bacteria,1NCHY@1224|Proteobacteria,42TM4@68525|delta/epsilon subdivisions,2WR4U@28221|Deltaproteobacteria,2MSGS@213462|Syntrophobacterales 28221|Deltaproteobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_543337_1 89187.ISM_05130 0.000133 47.4 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,46PAA@74030|Roseovarius 28211|Alphaproteobacteria C COG0277 FAD FMN-containing dehydrogenases - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_543337_2 1246474.ANBE01000035_gene2554 1.42e-20 97.4 COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,4EGXY@85012|Streptosporangiales 201174|Actinobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_1529645_1 234267.Acid_2793 4e-54 178.0 COG2197@1|root,COG2197@2|Bacteria,3Y7QM@57723|Acidobacteria 57723|Acidobacteria T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_655103_1 1131266.ARWQ01000001_gene1145 7.28e-36 132.0 COG0644@1|root,arCOG00570@2157|Archaea,41SBB@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - - - - - - - - - - - k59_655103_2 436308.Nmar_1513 1.12e-11 62.0 COG1325@1|root,arCOG01042@2157|Archaea,41SWK@651137|Thaumarchaeota 651137|Thaumarchaeota J RNA binding - - - ko:K07581 - - - - ko00000 - - - RNA_binding k59_10165_1 196162.Noca_3775 3.73e-52 177.0 COG1136@1|root,COG1136@2|Bacteria,2GM25@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1282148_2 338963.Pcar_0300 3.25e-33 117.0 COG1531@1|root,COG1531@2|Bacteria,1N7PM@1224|Proteobacteria,42X42@68525|delta/epsilon subdivisions,2WTGB@28221|Deltaproteobacteria 28221|Deltaproteobacteria AJ Protein of unknown function (DUF504) - - - - - - - - - - - - DUF504 k59_1282148_3 472759.Nhal_2244 1.15e-76 234.0 COG1544@1|root,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,1S5AA@1236|Gammaproteobacteria,1X0WB@135613|Chromatiales 135613|Chromatiales J PFAM Cold-shock protein, DNA-binding - - - - - - - - - - - - CSD,Ribosomal_S30AE k59_1066744_1 1033730.CAHG01000016_gene236 8.14e-07 49.7 COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria,4DRPI@85009|Propionibacteriales 201174|Actinobacteria K Lrp/AsnC ligand binding domain - - - - - - - - - - - - AsnC_trans_reg k59_1066744_2 575590.HMPREF0156_01194 6.99e-08 52.8 COG1129@1|root,COG1129@2|Bacteria,4PKVD@976|Bacteroidetes 976|Bacteroidetes G abc transporter (atp-binding protein) - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_702561_2 933262.AXAM01000101_gene2550 4.68e-16 78.2 COG0711@1|root,COG0711@2|Bacteria,1ND52@1224|Proteobacteria,42V20@68525|delta/epsilon subdivisions,2WRR4@28221|Deltaproteobacteria,2MKYZ@213118|Desulfobacterales 28221|Deltaproteobacteria C ATP synthase B/B' CF(0) - - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_283191_1 519989.ECTPHS_05145 3.22e-61 212.0 COG5373@1|root,COG5373@2|Bacteria,1N08V@1224|Proteobacteria 1224|Proteobacteria M membrane - - - - - - - - - - - - DUF2339 k59_440442_1 1189612.A33Q_3122 6.87e-45 155.0 COG2135@1|root,COG2135@2|Bacteria,4NKPN@976|Bacteroidetes,47MR7@768503|Cytophagia 976|Bacteroidetes S Belongs to the SOS response-associated peptidase family - - - - - - - - - - - - SRAP k59_909991_1 268746.Q58MX1_BPPRM 2.69e-22 103.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_961005_1 272134.KB731324_gene6648 5.52e-70 235.0 COG2114@1|root,COG2114@2|Bacteria,1FZXP@1117|Cyanobacteria,1H988@1150|Oscillatoriales 1117|Cyanobacteria T Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - 4.6.1.1 ko:K01768,ko:K03320 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko02000 1.A.11 - - DUF3365,Guanylate_cyc,HNOBA,PAS_9 k59_961005_2 298655.KI912266_gene4987 0.000106 45.4 COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,4ETPN@85013|Frankiales 201174|Actinobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_961006_2 84531.JMTZ01000027_gene13 6.32e-34 126.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1X3H0@135614|Xanthomonadales 135614|Xanthomonadales S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obgE - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_283199_1 1234595.C725_1816 2.66e-32 114.0 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2UBRZ@28211|Alphaproteobacteria,4BQX5@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_283199_2 265072.Mfla_0071 3.67e-91 289.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2VI1P@28216|Betaproteobacteria,2KMDT@206350|Nitrosomonadales 206350|Nitrosomonadales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_128874_1 595494.Tola_2147 1.88e-41 156.0 COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,1RMQ1@1236|Gammaproteobacteria,1Y43X@135624|Aeromonadales 135624|Aeromonadales L DNA polymerase polB - 2.7.7.7 ko:K02336 - - - - ko00000,ko01000,ko03400 - - - DNA_pol_B,DNA_pol_B_exo1 k59_544314_1 436308.Nmar_1704 1.33e-19 81.6 arCOG08775@1|root,arCOG08775@2157|Archaea,41T9K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_544314_2 436308.Nmar_1705 1.93e-88 263.0 COG0528@1|root,arCOG00858@2157|Archaea,41T1R@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_497601_1 314285.KT71_09662 2.74e-42 145.0 COG3637@1|root,COG3637@2|Bacteria,1RI4B@1224|Proteobacteria,1S8IK@1236|Gammaproteobacteria,1J6HR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl k59_497601_2 357808.RoseRS_1759 0.000771 42.7 COG2021@1|root,COG2021@2|Bacteria,2G5JD@200795|Chloroflexi,374TP@32061|Chloroflexia 32061|Chloroflexia E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metXA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1644227_1 1255043.TVNIR_3480 8.27e-96 295.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,1X0VD@135613|Chromatiales 135613|Chromatiales F Belongs to the dGTPase family. Type 2 subfamily - - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_81725_1 861299.J421_5794 9.74e-76 252.0 COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase k59_441671_1 1150864.MILUP08_43573 8.26e-89 275.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4DCB9@85008|Micromonosporales 201174|Actinobacteria C CoA-transferase family III - - 2.8.3.16,2.8.3.21 ko:K07749,ko:K08298 - - R10643,R10644 RC00014,RC00131 ko00000,ko01000 - - - CoA_transf_3 k59_911007_1 661367.LLO_0556 3.29e-36 137.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1JD22@118969|Legionellales 118969|Legionellales M 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) kdtA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N k59_81730_1 1502852.FG94_00890 2.24e-34 136.0 COG0515@1|root,COG2199@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,1R7HC@1224|Proteobacteria,2WGMD@28216|Betaproteobacteria,4791R@75682|Oxalobacteraceae 28216|Betaproteobacteria KLT Protein tyrosine kinase - - - - - - - - - - - - AAA_16,GGDEF,Pkinase k59_1437292_1 1123059.KB823014_gene155 4.5e-08 52.0 COG3636@1|root,COG3636@2|Bacteria,1N0RK@1224|Proteobacteria,2UDN3@28211|Alphaproteobacteria,43ZYG@69657|Hyphomonadaceae 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - - k59_1437292_2 1408444.JHYC01000008_gene1358 3.98e-40 136.0 COG3657@1|root,COG3657@2|Bacteria,1N74C@1224|Proteobacteria,1SCNC@1236|Gammaproteobacteria,1JFHI@118969|Legionellales 118969|Legionellales S Phage derived protein Gp49-like (DUF891) - - - - - - - - - - - - Gp49 k59_1283459_1 436229.JOEH01000004_gene121 1.44e-55 198.0 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,2NF7W@228398|Streptacidiphilus 201174|Actinobacteria V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_128909_1 443144.GM21_3343 1.69e-128 375.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria 28221|Deltaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_858620_1 519989.ECTPHS_06482 1.38e-103 324.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1WWYN@135613|Chromatiales 135613|Chromatiales U type IV pilus secretin PilQ - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_597135_1 667632.KB890169_gene4972 1.62e-45 168.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,1K04K@119060|Burkholderiaceae 28216|Betaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_813520_1 330214.NIDE2454 1.16e-97 297.0 COG0114@1|root,COG0114@2|Bacteria,3J0FU@40117|Nitrospirae 40117|Nitrospirae C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_1283470_1 177439.DP1080 7.08e-66 212.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,42M1J@68525|delta/epsilon subdivisions,2WIQR@28221|Deltaproteobacteria,2MIWY@213118|Desulfobacterales 28221|Deltaproteobacteria D TIGRFAM cell shape determining protein, MreB Mrl family mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_336596_1 870187.Thini_0883 4.07e-57 186.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,460VC@72273|Thiotrichales 72273|Thiotrichales C oxidase subunit III cyoC - 1.9.3.1 ko:K02164,ko:K02276,ko:K02299 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081,R00294 RC00016,RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10,3.D.4.4,3.D.4.5,3.D.4.6 - - COX3 k59_336602_1 1499967.BAYZ01000036_gene2402 9.74e-38 142.0 COG1032@1|root,COG1032@2|Bacteria 1499967.BAYZ01000036_gene2402|- C radical SAM domain protein - - - - - - - - - - - - - k59_10607_1 932213.SPM24T3_10586 1.07e-72 223.0 COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,1S3PW@1236|Gammaproteobacteria,400SU@613|Serratia 1236|Gammaproteobacteria M Outer membrane lipoprotein blc GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033554,GO:0044462,GO:0044464,GO:0050896,GO:0051716,GO:0071944 - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_10607_2 582744.Msip34_1308 1.82e-60 199.0 COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R2NF@1224|Proteobacteria,2VJDG@28216|Betaproteobacteria 28216|Betaproteobacteria K PFAM regulatory protein, MerR - - - ko:K22491 - - - - ko00000,ko03000 - - - B12-binding,B12-binding_2,MerR_1 k59_175691_1 1265490.JHVY01000006_gene1857 2.12e-94 314.0 COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria 1224|Proteobacteria Q Multicopper oxidase - - 1.16.3.3 ko:K22349 - - - - ko00000,ko01000 - - - - k59_231387_2 330214.NIDE0732 1.23e-16 75.9 COG4032@1|root,COG4032@2|Bacteria 2|Bacteria EH Thiamine pyrophosphate enzyme, N-terminal TPP binding domain ppd - 4.1.1.82 ko:K09459 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 - R04053 RC00506 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_N k59_1437339_1 998674.ATTE01000001_gene4056 4.72e-35 136.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,4608C@72273|Thiotrichales 72273|Thiotrichales P Citrate transporter - - - - - - - - - - - - CitMHS,TrkA_C k59_544361_1 521098.Aaci_1268 5.27e-22 93.2 COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,4HH23@91061|Bacilli,278BK@186823|Alicyclobacillaceae 91061|Bacilli K Belongs to the MraZ family mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - ko:K03925 - - - - ko00000 - - - MraZ k59_703568_1 223283.PSPTO_3188 2.29e-11 65.1 COG0510@1|root,COG0510@2|Bacteria,1N77Z@1224|Proteobacteria,1SF9H@1236|Gammaproteobacteria,1Z8M7@136849|Pseudomonas syringae group 1236|Gammaproteobacteria M Choline/ethanolamine kinase licA - - - - - - - - - - - APH,Choline_kinase,F-box k59_703568_2 1121929.KB898677_gene1789 4.19e-36 127.0 COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,4HA6U@91061|Bacilli,470X4@74385|Gracilibacillus 91061|Bacilli P Iron/manganese superoxide dismutases, C-terminal domain sodA GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_962094_1 1469245.JFBG01000036_gene1996 7.33e-97 296.0 COG2271@1|root,COG2271@2|Bacteria,1NJTU@1224|Proteobacteria,1SN72@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1380359_1 1280954.HPO_02422 6.18e-48 170.0 COG0625@1|root,COG0625@2|Bacteria,1R3VG@1224|Proteobacteria,2U50H@28211|Alphaproteobacteria,43XSS@69657|Hyphomonadaceae 28211|Alphaproteobacteria O COG0625 Glutathione S-transferase - - - - - - - - - - - - GST_C_2,GST_N_3 k59_1014931_1 228405.HNE_2486 3.27e-67 220.0 COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria 28211|Alphaproteobacteria CO COG0526, thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - AhpC-TSA k59_1067801_1 4787.PITG_01003T0 2.66e-05 51.6 COG0457@1|root,KOG1124@2759|Eukaryota,3QEK0@4776|Peronosporales 4776|Peronosporales S Domain of unknown function (DUF1736) - - - - - - - - - - - - DUF1736,TPR_8 k59_1644307_2 195522.BD01_1985 5.68e-13 72.0 COG1309@1|root,arCOG02643@2157|Archaea,2Y6RU@28890|Euryarchaeota,2454C@183968|Thermococci 183968|Thermococci K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1228028_1 436308.Nmar_0038 7.23e-112 323.0 COG0302@1|root,arCOG04542@2157|Archaea,41SGC@651137|Thaumarchaeota 651137|Thaumarchaeota H GTP cyclohydrolase I folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_1325006_2 207954.MED92_03667 8.36e-84 254.0 COG2755@1|root,COG2755@2|Bacteria,1RDVJ@1224|Proteobacteria,1T0DW@1236|Gammaproteobacteria,1XRQC@135619|Oceanospirillales 135619|Oceanospirillales E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 k59_284275_1 443254.Marpi_1295 0.000711 48.1 COG0417@1|root,COG0417@2|Bacteria 2|Bacteria L DNA replication proofreading polB - 2.7.7.7 ko:K02336,ko:K06877 - - - - ko00000,ko01000,ko03400 - - - CarbopepD_reg_2,DNA_pol_B,DNA_pol_B_exo1,RNase_H_2 k59_1014933_1 436308.Nmar_0560 5.25e-99 288.0 COG1225@1|root,arCOG00310@2157|Archaea,41SN5@651137|Thaumarchaeota 651137|Thaumarchaeota O AhpC/TSA antioxidant enzyme - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_656503_1 1121033.AUCF01000009_gene1086 3.79e-105 318.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria,2JPVB@204441|Rhodospirillales 204441|Rhodospirillales M Belongs to the UDP-glucose GDP-mannose dehydrogenase family rkpK - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_813571_1 1158601.I585_04551 1.35e-51 172.0 COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,4HDH1@91061|Bacilli,4AZII@81852|Enterococcaceae 91061|Bacilli V ABC transporter, ATP-binding protein drrA - - ko:K01990,ko:K09695 ko02010,map02010 M00252,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.102 - - ABC_tran k59_703582_1 877414.ATWA01000007_gene171 2.85e-17 79.0 COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia 186801|Clostridia C aerobic-type carbon monoxide dehydrogenase, small subunit CoxS - - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 k59_656507_1 436308.Nmar_1011 4.47e-107 319.0 COG0778@1|root,arCOG00288@2157|Archaea 2157|Archaea C Nitroreductase - - 1.5.1.39 ko:K19286 ko00740,ko01100,map00740,map01100 - R05705,R05706 RC00126 ko00000,ko00001,ko01000 - - - Nitroreductase k59_813574_1 479434.Sthe_2674 9.69e-43 159.0 COG0527@1|root,COG0527@2|Bacteria,2G5U9@200795|Chloroflexi,27XET@189775|Thermomicrobia 189775|Thermomicrobia E ACT domain - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT_7 k59_668010_2 1379270.AUXF01000004_gene3280 4.89e-27 105.0 COG2096@1|root,COG2096@2|Bacteria,1ZT4I@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Cobalamin adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_552754_1 1121423.JONT01000004_gene1612 1.29e-74 249.0 COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,260ER@186807|Peptococcaceae 186801|Clostridia J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_92751_1 679200.HMPREF9333_01411 3.55e-57 189.0 COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia 186801|Clostridia O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_761645_1 1248232.BANQ01000092_gene3125 2.14e-39 135.0 COG3584@1|root,COG3584@2|Bacteria,1MZPJ@1224|Proteobacteria,1SBH0@1236|Gammaproteobacteria,1XXJZ@135623|Vibrionales 135623|Vibrionales S 3D domain protein DR0488 - - - - - - - - - - - - k59_761645_2 518766.Rmar_1185 4.38e-118 358.0 COG3250@1|root,COG3250@2|Bacteria,4NESZ@976|Bacteroidetes 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.31 ko:K01195 ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142 M00014,M00076,M00077,M00078,M00129 R01478,R04979,R07818,R08127,R08260,R10830 RC00055,RC00171,RC00529,RC00530,RC00714,RC01251 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_239771_1 314254.OA2633_04191 2.73e-09 60.8 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,43WQS@69657|Hyphomonadaceae 28211|Alphaproteobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase k59_239771_2 436229.JOEH01000021_gene7745 5.83e-16 74.3 COG4319@1|root,COG4319@2|Bacteria,2IFX9@201174|Actinobacteria 201174|Actinobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_1238572_1 1140.Synpcc7942_0928 1.94e-09 64.7 COG4775@1|root,COG4775@2|Bacteria,1G389@1117|Cyanobacteria,1GYVJ@1129|Synechococcus 1117|Cyanobacteria M Outer membrane protein protective antigen OMA87 IAP75 - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA,POTRA_2 k59_825147_1 344747.PM8797T_27949 6.65e-36 125.0 COG3436@1|root,COG3436@2|Bacteria 2|Bacteria L PFAM IS66 Orf2 family protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_825147_2 234267.Acid_2941 5.17e-29 113.0 2DB88@1|root,2Z7QT@2|Bacteria,3Y61J@57723|Acidobacteria 2|Bacteria S Domain of unknown function (DUF4338) - - - - - - - - - - - - DUF4338 k59_1022971_1 224308.BSU09420 4.18e-07 54.7 COG0791@1|root,COG1388@1|root,COG0791@2|Bacteria,COG1388@2|Bacteria,1TP24@1239|Firmicutes,4HA77@91061|Bacilli,1ZCHY@1386|Bacillus 91061|Bacilli M COG1388 FOG LysM repeat lytE - - ko:K19220,ko:K19223,ko:K19224 - - - - ko00000,ko01000,ko01002,ko01011 - CBM50 - LysM,NLPC_P60 k59_1077721_1 396588.Tgr7_1176 9.96e-180 537.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales 135613|Chromatiales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon k59_1387834_1 287.DR97_5908 7.85e-44 155.0 COG0753@1|root,COG0753@2|Bacteria,1RC6W@1224|Proteobacteria,1S3BQ@1236|Gammaproteobacteria,1YDH0@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria P Catalase - - - - - - - - - - - - Catalase k59_14800_1 1158756.AQXQ01000011_gene628 1.11e-102 319.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales 135613|Chromatiales L PFAM UvrD REP helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_669362_1 247634.GPB2148_2699 1.76e-42 149.0 COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,1TH2Y@1236|Gammaproteobacteria,1J4CC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O protein required for cytochrome oxidase assembly - - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_510578_1 999141.GME_12434 7.83e-50 165.0 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,1S63J@1236|Gammaproteobacteria,1XJZ1@135619|Oceanospirillales 135619|Oceanospirillales H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK k59_15541_1 323261.Noc_2112 3.31e-73 230.0 COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,1RNGA@1236|Gammaproteobacteria,1WX4Y@135613|Chromatiales 135613|Chromatiales G Protein of unknown function (DUF455) - - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF455 k59_922565_1 1121127.JAFA01000005_gene4929 1.68e-88 273.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2VHDY@28216|Betaproteobacteria,1K3NA@119060|Burkholderiaceae 28216|Betaproteobacteria C NADH flavin oxidoreductase NADH oxidase namA - 1.3.1.34 ko:K00219 - - - - ko00000,ko01000 - - - Oxidored_FMN k59_1131172_1 1175306.GWL_21770 1.78e-49 173.0 COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,2VHUR@28216|Betaproteobacteria,47319@75682|Oxalobacteraceae 28216|Betaproteobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1,MFS_3 k59_1296327_2 1082932.ATCR1_13921 1.2e-10 63.2 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,2TU1S@28211|Alphaproteobacteria,4B98C@82115|Rhizobiaceae 28211|Alphaproteobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008144,GO:0016829,GO:0016840,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:1901681,GO:1904047 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_1131181_1 1229909.NSED_06860 1.96e-100 311.0 COG0464@1|root,arCOG01308@2157|Archaea,41S7X@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48) domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_1503944_1 909943.HIMB100_00003040 2.62e-141 412.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,4BRAF@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_510603_1 444862.E3SLV0_9CAUD 3.99e-34 131.0 4QI9F@10662|Myoviridae 10662|Myoviridae S Type III restriction enzyme, res subunit - - - - - - - - - - - - - k59_922591_1 1469245.JFBG01000010_gene592 1.86e-77 241.0 COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,1RYQS@1236|Gammaproteobacteria,1WWAX@135613|Chromatiales 135613|Chromatiales H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - - - - - - - - - - ApbA,ApbA_C k59_1657250_1 90813.JQMT01000001_gene1784 3.51e-15 70.5 COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1S8TB@1236|Gammaproteobacteria,460YN@72273|Thiotrichales 72273|Thiotrichales S Protein of unknown function (DUF971) - - - - - - - - - - - - DUF971 k59_1657250_2 1166948.JPZL01000002_gene1105 1.64e-51 170.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1XI77@135619|Oceanospirillales 135619|Oceanospirillales H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_453560_1 1469245.JFBG01000013_gene1927 7.48e-266 732.0 COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,1RSIM@1236|Gammaproteobacteria,1WW7Y@135613|Chromatiales 135613|Chromatiales C reductase, dissimilatory-type alpha subunit - - 1.8.99.5 ko:K11180 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_453560_2 1163617.SCD_n00476 2.07e-108 325.0 COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,2VIG6@28216|Betaproteobacteria 28216|Betaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_453560_3 1249627.D779_2141 1.39e-23 90.9 2E3CD@1|root,32YBP@2|Bacteria,1N8PD@1224|Proteobacteria,1SCSK@1236|Gammaproteobacteria,1WZ7C@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_453560_4 713586.KB900536_gene1008 6.55e-38 134.0 2CARE@1|root,2Z8Q5@2|Bacteria,1R7S8@1224|Proteobacteria,1RRAH@1236|Gammaproteobacteria,1WW2H@135613|Chromatiales 135613|Chromatiales S TIGRFAM CRISPR-associated protein - - - - - - - - - - - - Cas6 k59_971475_1 272624.lpg1094 1.44e-31 125.0 COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,1RRRP@1236|Gammaproteobacteria,1JCMG@118969|Legionellales 118969|Legionellales MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_712919_1 243233.MCA0072 4.79e-29 111.0 COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1XEER@135618|Methylococcales 135618|Methylococcales S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_712919_2 158787.BSCA_2473 4.07e-09 59.7 COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,2ISCW@201174|Actinobacteria,4D0HC@85004|Bifidobacteriales 201174|Actinobacteria S AMMECR1 - - - ko:K06990 - - - - ko00000,ko04812 - - - AMMECR1,Memo k59_1447403_2 1048983.EL17_21420 4.12e-05 47.0 COG4804@1|root,COG4804@2|Bacteria,4NGY8@976|Bacteroidetes,47M65@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF1016) - - - - - - - - - - - - DUF1016 k59_510631_1 1469245.JFBG01000083_gene229 3.55e-45 157.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria 1224|Proteobacteria S permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_453578_2 1504981.KO116_0953 2.3e-44 154.0 COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RM84@1236|Gammaproteobacteria,1XHX0@135619|Oceanospirillales 135619|Oceanospirillales C lysine 2,3-aminomutase epmB - - ko:K19810 - - - - ko00000,ko01000,ko03012 - - - Fer4_12,Fer4_14,Radical_SAM k59_922620_1 330214.NIDE4168 7.88e-47 170.0 COG0475@1|root,COG0490@1|root,COG1226@1|root,COG0475@2|Bacteria,COG0490@2|Bacteria,COG1226@2|Bacteria,3J0Y7@40117|Nitrospirae 40117|Nitrospirae P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_826572_1 1297865.APJD01000024_gene401 1.52e-16 82.0 COG0790@1|root,COG4249@1|root,COG0790@2|Bacteria,COG4249@2|Bacteria,1Q8Z3@1224|Proteobacteria,2V7DR@28211|Alphaproteobacteria,3K2ES@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Caspase domain - - - - - - - - - - - - Peptidase_C14 k59_183790_1 670307.HYPDE_27263 1.86e-37 137.0 COG1957@1|root,COG1957@2|Bacteria,1NF7X@1224|Proteobacteria,2UGA6@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Protein of unknown function, DUF547 - - - - - - - - - - - - DUF547 k59_295537_1 1267005.KB911256_gene1810 8.85e-09 60.1 COG0666@1|root,COG0666@2|Bacteria,1P877@1224|Proteobacteria,2U33E@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0666 FOG Ankyrin repeat - - - - - - - - - - - - Ank,Ank_2 k59_867639_1 1469245.JFBG01000049_gene2176 5.73e-122 369.0 COG1520@1|root,COG1520@2|Bacteria,1QXZ5@1224|Proteobacteria,1SZJA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - k59_15588_1 485913.Krac_3951 5.32e-98 300.0 COG3666@1|root,COG3666@2|Bacteria,2G998@200795|Chloroflexi 200795|Chloroflexi L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_669432_1 666681.M301_0647 5.48e-67 215.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,2KKV0@206350|Nitrosomonadales 206350|Nitrosomonadales NU PFAM type II secretion system protein E - - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_669432_2 697282.Mettu_0065 1.78e-137 405.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU twitching motility protein uptC - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_453587_1 382464.ABSI01000005_gene1300 3.85e-16 85.5 COG3137@1|root,COG3137@2|Bacteria,46TU0@74201|Verrucomicrobia 74201|Verrucomicrobia M Protein of unknown function, DUF481 - - - - - - - - - - - - DUF481 k59_922635_1 215803.DB30_5880 1.24e-103 342.0 COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,42Z37@68525|delta/epsilon subdivisions,2WUNE@28221|Deltaproteobacteria,2YZFR@29|Myxococcales 28221|Deltaproteobacteria Q Multicopper oxidase - - - - - - - - - - - - - k59_453592_1 96561.Dole_0808 1.04e-66 215.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42PIB@68525|delta/epsilon subdivisions,2WKFC@28221|Deltaproteobacteria,2MMZK@213118|Desulfobacterales 28221|Deltaproteobacteria V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1079182_1 435908.IDSA_10410 5.89e-39 136.0 COG0811@1|root,COG0811@2|Bacteria,1MX60@1224|Proteobacteria,1RRX1@1236|Gammaproteobacteria,2QFR5@267893|Idiomarinaceae 1236|Gammaproteobacteria U Biopolymer - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_712943_2 491205.JARQ01000003_gene2047 1.52e-28 112.0 COG0171@1|root,COG0171@2|Bacteria,4NEXG@976|Bacteroidetes,1HYCI@117743|Flavobacteriia,3ZQ5M@59732|Chryseobacterium 976|Bacteroidetes H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source nadE - 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - NAD_synthase k59_922644_1 330214.NIDE0310 9.98e-108 327.0 COG1053@1|root,COG1053@2|Bacteria,3J0ZM@40117|Nitrospirae 40117|Nitrospirae C Fumarate reductase flavoprotein C-term - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_669450_1 1121374.KB891576_gene649 4.13e-18 88.6 COG4733@1|root,COG4733@2|Bacteria,1R2H0@1224|Proteobacteria,1SJ1I@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Fibronectin type III domain - - - - - - - - - - - - - k59_94241_2 485917.Phep_2087 1.14e-14 75.5 COG0415@1|root,COG0415@2|Bacteria,4NEDW@976|Bacteroidetes,1IWVB@117747|Sphingobacteriia 976|Bacteroidetes L DNA photolyase phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_605885_1 994479.GL877878_gene1850 1.94e-14 79.3 COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4E04T@85010|Pseudonocardiales 201174|Actinobacteria S PFAM Uncharacterised protein family UPF0182 - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K09118 - - - - ko00000 - - - UPF0182 k59_826619_1 880073.Calab_0992 4.6e-67 213.0 COG2006@1|root,COG2006@2|Bacteria,2NQF7@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 k59_669465_1 1265313.HRUBRA_00562 1.91e-140 412.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1J4ST@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0306 Phosphate sulphate permeases pitA GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_605896_1 391625.PPSIR1_01774 1.49e-25 106.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42QKW@68525|delta/epsilon subdivisions,2WKH1@28221|Deltaproteobacteria,2YWTQ@29|Myxococcales 1224|Proteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_605896_2 1077144.AGFF01000017_gene2745 3.1e-29 112.0 COG3752@1|root,COG3752@2|Bacteria,2GNX1@201174|Actinobacteria 201174|Actinobacteria S Protein of unknown function (DUF1295) - - - - - - - - - - - - DUF1295 k59_553871_2 983917.RGE_30920 1.3e-14 73.9 COG1679@1|root,COG1679@2|Bacteria,1NFH4@1224|Proteobacteria,2VISW@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF521) - - - ko:K09123 - - - - ko00000 - - - DUF521 k59_867672_1 998088.B565_0972 1.39e-56 187.0 COG0338@1|root,COG0338@2|Bacteria,1P85S@1224|Proteobacteria,1RMNW@1236|Gammaproteobacteria,1Y3DM@135624|Aeromonadales 135624|Aeromonadales L D12 class N6 adenine-specific DNA methyltransferase dam - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_1388889_2 1123242.JH636434_gene4961 7.68e-22 105.0 COG0457@1|root,COG3119@1|root,COG0457@2|Bacteria,COG3119@2|Bacteria,2J3IX@203682|Planctomycetes 203682|Planctomycetes P arylsulfatase A - - - - - - - - - - - - Sulfatase,TPR_16,TPR_19,TPR_2 k59_510707_1 1397528.Q671_02410 4.63e-29 114.0 COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,1S4UH@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Mut7-C RNAse domain - - - ko:K09122 - - - - ko00000 - - - Mut7-C,Ub-Mut7C k59_295614_1 862908.BMS_1128 7.51e-14 69.3 COG1432@1|root,COG1432@2|Bacteria,1QC1U@1224|Proteobacteria,42TAH@68525|delta/epsilon subdivisions,2WPYX@28221|Deltaproteobacteria 28221|Deltaproteobacteria S NYN domain - - - - - - - - - - - - NYN k59_295614_2 713586.KB900536_gene1609 1.95e-18 81.3 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Peptidyl-prolyl cis-trans slyD GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010467,GO:0016151,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022417,GO:0031647,GO:0035821,GO:0036211,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043963,GO:0044003,GO:0044068,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044501,GO:0046872,GO:0046914,GO:0050821,GO:0050896,GO:0050897,GO:0051082,GO:0051604,GO:0051701,GO:0051704,GO:0051817,GO:0052027,GO:0052250,GO:0065007,GO:0065008,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_971547_1 330214.NIDE1018 7.62e-84 263.0 COG1530@1|root,COG1530@2|Bacteria,3J0DK@40117|Nitrospirae 40117|Nitrospirae J Ribonuclease E/G family - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G k59_1024006_1 1440774.Y900_011750 1.05e-47 165.0 COG1237@1|root,COG1237@2|Bacteria,2I8H7@201174|Actinobacteria,23ACA@1762|Mycobacteriaceae 201174|Actinobacteria S Metallo-beta-lactamase superfamily - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - Lactamase_B k59_398887_1 688269.Theth_0549 6.35e-30 119.0 COG1052@1|root,COG1052@2|Bacteria 2|Bacteria CH NAD binding MA20_03535 - 1.1.1.399,1.1.1.95 ko:K00058,ko:K04496 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko04310,ko04330,ko05200,ko05220,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map04310,map04330,map05200,map05220 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_398887_2 304371.MCP_0861 1.48e-08 57.4 COG0269@1|root,arCOG00053@2157|Archaea,2XV47@28890|Euryarchaeota,2N9E0@224756|Methanomicrobia 224756|Methanomicrobia G Orotidine 5'-phosphate decarboxylase - - 4.1.2.43,5.3.1.27 ko:K13831 ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230 M00345,M00580 R05338,R05339,R09780 RC00377,RC00421,RC00422 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase,RraA-like k59_510727_1 204669.Acid345_1270 6.36e-70 233.0 COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia 204432|Acidobacteriia Q Flavin containing amine oxidoreductase - - - - - - - - - - - - NAD_binding_8 k59_922715_1 1434929.X946_727 5.66e-45 162.0 COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2VPTU@28216|Betaproteobacteria,1KDJU@119060|Burkholderiaceae 28216|Betaproteobacteria G FGGY family of carbohydrate kinase, N-terminal domain protein xylB2 - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_15668_1 1380394.JADL01000014_gene203 6.67e-105 319.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2U1QF@28211|Alphaproteobacteria,2JVYJ@204441|Rhodospirillales 204441|Rhodospirillales C Fumarate reductase flavoprotein C-term - - - - - - - - - - - - FAD_binding_2,Succ_DH_flav_C k59_1333460_1 1249627.D779_0407 5.29e-91 279.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1WVX6@135613|Chromatiales 135613|Chromatiales G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_140599_2 374847.Kcr_0915 7.96e-14 71.2 arCOG04118@1|root,arCOG04118@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_713000_1 1121939.L861_01750 2.84e-25 99.8 2C1W2@1|root,31MWG@2|Bacteria 2|Bacteria S Protein of unknown function (DUF4242) - - - - - - - - - - - - DUF4242 k59_713000_2 1082933.MEA186_09540 8.97e-14 68.6 COG1765@1|root,COG1765@2|Bacteria,1RBJN@1224|Proteobacteria,2VF54@28211|Alphaproteobacteria,43MJG@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O OsmC-like protein - - - - - - - - - - - - OsmC k59_408780_1 478741.JAFS01000002_gene551 2.91e-82 266.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,46SVA@74201|Verrucomicrobia,37FY0@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_615720_1 400682.PAC_15705790 6.9e-183 534.0 COG0843@1|root,COG1622@1|root,KOG4767@2759|Eukaryota,KOG4769@2759|Eukaryota,38JQ7@33154|Opisthokonta,3BGCX@33208|Metazoa 33208|Metazoa C electron transport coupled proton transport - - - - - - - - - - - - COX1,COX2 k59_149685_1 1229909.NSED_03355 4.67e-122 385.0 COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota 651137|Thaumarchaeota D SMC proteins Flexible Hinge Domain - - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_877334_1 1123261.AXDW01000002_gene1648 7.85e-85 263.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1X3KV@135614|Xanthomonadales 135614|Xanthomonadales C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_463405_2 1395571.TMS3_0114210 4.76e-30 116.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S permease perM - - - - - - - - - - - AI-2E_transport k59_722884_1 247634.GPB2148_3632 1.23e-71 231.0 COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,1S1SA@1236|Gammaproteobacteria,1J8ND@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Trimethylamine methyltransferase (MTTB) - - - - - - - - - - - - MTTB k59_933146_1 1267533.KB906733_gene3448 2.58e-40 156.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - TPR_16,TPR_8 k59_463407_1 1519464.HY22_10310 4.24e-43 147.0 COG0528@1|root,COG0528@2|Bacteria,1FD6T@1090|Chlorobi 1090|Chlorobi F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_463407_2 330214.NIDE2760 3.73e-99 291.0 COG0233@1|root,COG0233@2|Bacteria,3J0KJ@40117|Nitrospirae 40117|Nitrospirae J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_463407_3 246194.CHY_0667 6.28e-21 92.8 COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,42EZ0@68295|Thermoanaerobacterales 186801|Clostridia M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_1033809_1 471852.Tcur_1573 1.64e-35 138.0 COG0277@1|root,COG0277@2|Bacteria,2GKQR@201174|Actinobacteria,4EFTT@85012|Streptosporangiales 201174|Actinobacteria C FAD binding domain - - - - - - - - - - - - FAD_binding_4 k59_1342071_2 67352.JODS01000020_gene3948 1.98e-13 72.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family feaB - 1.2.1.39,1.2.1.8 ko:K00130,ko:K00146 ko00260,ko00360,ko00643,ko01100,ko01120,map00260,map00360,map00643,map01100,map01120 M00555 R02536,R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1033810_1 330214.NIDE2469 1.04e-141 411.0 COG0439@1|root,COG0439@2|Bacteria,3J0AJ@40117|Nitrospirae 40117|Nitrospirae I Biotin carboxylase C-terminal domain - - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_408810_1 335543.Sfum_0899 3.69e-108 330.0 COG0490@1|root,COG0569@1|root,COG1226@1|root,COG0490@2|Bacteria,COG0569@2|Bacteria,COG1226@2|Bacteria,1R4J8@1224|Proteobacteria,42NKU@68525|delta/epsilon subdivisions,2WIRH@28221|Deltaproteobacteria,2MRD0@213462|Syntrophobacterales 28221|Deltaproteobacteria P Ion channel - - - - - - - - - - - - Ion_trans_2,TrkA_C,TrkA_N k59_979420_1 43354.JOIJ01000026_gene3295 2.91e-25 104.0 COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,4DYE9@85010|Pseudonocardiales 201174|Actinobacteria Q Cytochrome P450 - - - - - - - - - - - - p450 k59_979420_2 1266998.ATUJ01000007_gene300 3.9e-11 61.6 COG0589@1|root,COG0589@2|Bacteria,1PR99@1224|Proteobacteria,2V3IN@28211|Alphaproteobacteria,2PYR4@265|Paracoccus 28211|Alphaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_149713_2 350688.Clos_0541 6.38e-28 112.0 COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia,36DHZ@31979|Clostridiaceae 186801|Clostridia F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - iHN637.CLJU_RS04230 AICARFT_IMPCHas,MGS k59_193660_1 690850.Desaf_0477 2.2e-55 189.0 COG2367@1|root,COG2367@2|Bacteria,1R4Y9@1224|Proteobacteria,42YC9@68525|delta/epsilon subdivisions,2WTSH@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Beta-lactamase - - - - - - - - - - - - - k59_1089552_1 370438.PTH_1586 4.43e-115 352.0 COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,261BK@186807|Peptococcaceae 186801|Clostridia G Domain of unknown function (DUF3459) - - 2.4.1.18,3.2.1.141 ko:K00700,ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110,R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48,DUF3459 k59_1248921_2 443144.GM21_1798 8.43e-58 204.0 COG0784@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1 k59_1605808_1 4555.Si029923m 6.08e-63 207.0 COG1304@1|root,KOG0538@2759|Eukaryota,37QEA@33090|Viridiplantae,3GADE@35493|Streptophyta,3KXE2@4447|Liliopsida,3I4JE@38820|Poales 35493|Streptophyta C FMN-dependent dehydrogenase - GO:0003674,GO:0003824,GO:0003973,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0008150,GO:0008152,GO:0008891,GO:0009853,GO:0009987,GO:0010109,GO:0016032,GO:0016491,GO:0016614,GO:0016899,GO:0019048,GO:0019222,GO:0031323,GO:0035821,GO:0042579,GO:0043094,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044003,GO:0044237,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051701,GO:0051704,GO:0051817,GO:0055114,GO:0065007 1.1.3.15 ko:K11517 ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00630,map01100,map01110,map01120,map01130,map01200,map04146 M00532 R00475 RC00042 ko00000,ko00001,ko00002,ko01000 - - - FMN_dh k59_615789_1 1121091.AUMP01000013_gene3302 2.12e-12 72.8 COG2027@1|root,COG2027@2|Bacteria,1TQFQ@1239|Firmicutes,4HA3X@91061|Bacilli 91061|Bacilli M D-alanyl-D-alanine carboxypeptidase dacC - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_250817_1 626418.bglu_2g22720 1.03e-49 177.0 COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,2VPPA@28216|Betaproteobacteria,1K1AX@119060|Burkholderiaceae 28216|Betaproteobacteria I Squalene--hopene cyclase shc - 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 - R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 - - - SQHop_cyclase_C,SQHop_cyclase_N k59_306095_1 1123508.JH636442_gene4067 0.000393 50.1 COG0515@1|root,COG0515@2|Bacteria,2IYM4@203682|Planctomycetes 203682|Planctomycetes KLT Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1185868_1 709484.E5DHW9_9CAUD 7.7e-19 88.6 4QBA2@10239|Viruses,4QV98@35237|dsDNA viruses no RNA stage,4QPPI@28883|Caudovirales,4QIA3@10662|Myoviridae 10662|Myoviridae S Thymidylate synthase - GO:0003674,GO:0003824,GO:0004799,GO:0008150,GO:0008152,GO:0008168,GO:0016740,GO:0016741,GO:0032259,GO:0042083 - - - - - - - - - - - k59_772140_1 123214.PERMA_0645 4.53e-45 167.0 COG2239@1|root,COG2239@2|Bacteria 2|Bacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N,PRC k59_358067_1 1148.1651932 5.16e-63 219.0 COG2199@1|root,COG5001@1|root,COG3706@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H6J1@1142|Synechocystis 1117|Cyanobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_9,Response_reg k59_1248951_1 1229909.NSED_06795 1.31e-28 107.0 arCOG10408@1|root,arCOG10408@2157|Archaea,41T82@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1248951_2 436308.Nmar_1193 2.29e-12 66.2 COG1064@1|root,arCOG01455@2157|Archaea,41SK3@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_306110_1 511062.GU3_07340 2.11e-72 238.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1Y3IQ@135624|Aeromonadales 135624|Aeromonadales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_358075_1 930169.B5T_04425 3.54e-50 170.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1XHMA@135619|Oceanospirillales 135619|Oceanospirillales K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_877402_1 637905.SVI_2999 2.99e-63 202.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,1RNSW@1236|Gammaproteobacteria,2QATH@267890|Shewanellaceae 1236|Gammaproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD GO:0003674,GO:0003824,GO:0004477,GO:0004486,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0055114,GO:0071704,GO:1901360,GO:1901564 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - iSDY_1059.SDY_0281 THF_DHG_CYH,THF_DHG_CYH_C k59_933220_1 323261.Noc_2480 1.12e-35 134.0 COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,1RPY4@1236|Gammaproteobacteria,1WVV1@135613|Chromatiales 135613|Chromatiales M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_563789_1 1229909.NSED_07475 9.63e-68 214.0 COG0500@1|root,COG2835@1|root,arCOG01791@2157|Archaea,arCOG04124@2157|Archaea,41T4S@651137|Thaumarchaeota 651137|Thaumarchaeota Q Methyltransferase domain - - - - - - - - - - - - - k59_250859_1 1123274.KB899410_gene3492 4.66e-21 97.1 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2J6FV@203691|Spirochaetes 203691|Spirochaetes T Adenylate guanylate cyclase catalytic domain protein - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_193755_1 1469245.JFBG01000008_gene767 6.22e-23 100.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1WX0W@135613|Chromatiales 135613|Chromatiales N transport system - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC_transp_aux k59_877437_1 572477.Alvin_0020 1.44e-44 154.0 COG3658@1|root,COG3658@2|Bacteria,1N28F@1224|Proteobacteria,1S2S2@1236|Gammaproteobacteria,1WXYZ@135613|Chromatiales 135613|Chromatiales C PFAM Di-haem cytochrome c - - - - - - - - - - - - DHC k59_1142063_1 1123367.C666_04520 2.5e-06 51.2 COG0631@1|root,COG0631@2|Bacteria,1N72S@1224|Proteobacteria,2VK9S@28216|Betaproteobacteria,2KVCJ@206389|Rhodocyclales 206389|Rhodocyclales T phosphatase - - - - - - - - - - - - PP2C_2 k59_1142063_2 1031711.RSPO_c01297 8.02e-45 160.0 COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHMW@28216|Betaproteobacteria,1K1ZC@119060|Burkholderiaceae 28216|Betaproteobacteria KLT Serine threonine protein kinase spkD - - - - - - - - - - - Pkinase k59_463543_1 9733.XP_004282654.1 1.17e-48 181.0 COG1331@1|root,KOG2244@2759|Eukaryota,38VM1@33154|Opisthokonta,3BDEY@33208|Metazoa,3CTDG@33213|Bilateria,489FR@7711|Chordata,4910U@7742|Vertebrata,3J43A@40674|Mammalia,4IWBK@91561|Cetartiodactyla 33208|Metazoa O spermatogenesis associated 20 SPATA20 GO:0000003,GO:0007276,GO:0007283,GO:0008150,GO:0019953,GO:0022414,GO:0032501,GO:0032504,GO:0044703,GO:0048232,GO:0048609,GO:0051704 - - - - - - - - - - GlcNAc_2-epim,Thioredox_DsbH k59_306181_1 436308.Nmar_1773 3.31e-125 372.0 COG0668@1|root,arCOG01568@2157|Archaea,41SYX@651137|Thaumarchaeota 651137|Thaumarchaeota M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_358136_1 296591.Bpro_5285 8.27e-131 385.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VJDW@28216|Betaproteobacteria,4ACE1@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM L-carnitine dehydratase bile acid-inducible protein F - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_358136_2 1469245.JFBG01000036_gene1974 1.05e-98 303.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGB@1236|Gammaproteobacteria,1X1MI@135613|Chromatiales 135613|Chromatiales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_149825_1 519989.ECTPHS_04329 4.32e-94 288.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1WXA3@135613|Chromatiales 135613|Chromatiales U General secretion pathway protein F - - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_877460_1 1249627.D779_1371 2.52e-109 332.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales 135613|Chromatiales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1185970_3 283699.D172_1435 4.46e-25 101.0 COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria,2Q16A@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K Transcriptional regulator hdfR - - - - - - - - - - - HTH_1,LysR_substrate k59_463561_1 1403819.BATR01000114_gene3993 1.02e-05 50.4 COG0457@1|root,COG1225@1|root,COG0457@2|Bacteria,COG1225@2|Bacteria,46U46@74201|Verrucomicrobia 74201|Verrucomicrobia O Redoxin - - - - - - - - - - - - AhpC-TSA k59_250924_1 375451.RD1_B0013 7.78e-10 60.8 COG4618@1|root,COG4618@2|Bacteria,1NR1Z@1224|Proteobacteria,2UQSB@28211|Alphaproteobacteria,2P4JV@2433|Roseobacter 28211|Alphaproteobacteria P ABC transporter transmembrane region - - - ko:K06148 - - - - ko00000,ko02000 3.A.1 - - ABC_membrane,ABC_tran k59_250924_2 1038862.KB893860_gene2620 3.82e-22 97.1 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2TSP0@28211|Alphaproteobacteria,3JV7I@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M HlyD membrane-fusion protein of T1SS - - - ko:K02022,ko:K16300 - M00571 - - ko00000,ko00002,ko02000,ko02044 8.A.1.3.3 - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_1342222_2 1121875.KB907546_gene2238 9.76e-40 143.0 COG1409@1|root,COG1409@2|Bacteria,4NFAP@976|Bacteroidetes,1I2DE@117743|Flavobacteriia 976|Bacteroidetes S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos,PA14 k59_979583_1 395493.BegalDRAFT_0520 6.05e-80 259.0 COG5002@1|root,COG5002@2|Bacteria,1QTSA@1224|Proteobacteria,1T1PH@1236|Gammaproteobacteria,463U3@72273|Thiotrichales 72273|Thiotrichales T Two-component sensor kinase N-terminal - - - - - - - - - - - - 2CSK_N,HATPase_c,HisKA k59_772220_1 32057.KB217478_gene6005 1.85e-07 53.9 COG0517@1|root,COG0517@2|Bacteria,1G5TQ@1117|Cyanobacteria,1HN52@1161|Nostocales 1117|Cyanobacteria S PFAM CBS domain - - - ko:K07182 - - - - ko00000 - - - CBS k59_306208_1 1267535.KB906767_gene3370 8.49e-98 294.0 COG0160@1|root,COG0160@2|Bacteria,3Y4EV@57723|Acidobacteria,2JKID@204432|Acidobacteriia 204432|Acidobacteriia E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.55 ko:K15372 ko00410,ko00430,ko01100,map00410,map00430,map01100 - R00908,R01684 RC00006,RC00062 ko00000,ko00001,ko01000 - - - Aminotran_3 k59_877479_1 330214.NIDE1580 3.66e-73 242.0 COG1452@1|root,COG1452@2|Bacteria,3J0QI@40117|Nitrospirae 40117|Nitrospirae M involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA k59_1144357_1 1121918.ARWE01000001_gene180 1.45e-35 125.0 COG4446@1|root,COG4446@2|Bacteria,1N7IZ@1224|Proteobacteria,42V21@68525|delta/epsilon subdivisions,2WRFF@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function (DUF1499) - - - - - - - - - - - - DUF1499 k59_1144357_2 1009370.ALO_15422 1.36e-13 71.2 COG4948@1|root,COG4948@2|Bacteria,1TS0S@1239|Firmicutes,4H4FY@909932|Negativicutes 909932|Negativicutes M mandelate racemase muconate lactonizing - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_981598_1 629265.PMA4326_22359 1.81e-38 135.0 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,1RNGM@1236|Gammaproteobacteria,1Z68X@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S N-terminal domain of oxidoreductase yfmJ - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N k59_981598_2 1170562.Cal6303_3874 4.78e-07 51.2 COG3670@1|root,COG3670@2|Bacteria,1G11V@1117|Cyanobacteria,1HKF2@1161|Nostocales 1117|Cyanobacteria Q PFAM Retinal pigment epithelial membrane protein - - 1.13.11.75 ko:K00464 - - R09601 RC00912 ko00000,ko01000 - - - RPE65 k59_465424_1 330214.NIDE0603 1.09e-100 306.0 COG1008@1|root,COG1008@2|Bacteria,3J0EQ@40117|Nitrospirae 40117|Nitrospirae C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1091601_1 518766.Rmar_2737 2.58e-65 212.0 COG0438@1|root,COG0438@2|Bacteria,4NKJ9@976|Bacteroidetes,1FING@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_724560_1 479434.Sthe_2778 2.37e-67 214.0 COG1319@1|root,COG1319@2|Bacteria,2G84Z@200795|Chloroflexi,27Z3G@189775|Thermomicrobia 189775|Thermomicrobia C CO dehydrogenase flavoprotein C-terminal domain - - 1.2.5.3 ko:K03519 - - R11168 RC02800 ko00000,ko01000 - - - CO_deh_flav_C,FAD_binding_5 k59_1144399_1 626418.bglu_1g31470 2.1e-93 287.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2VHFR@28216|Betaproteobacteria,1K313@119060|Burkholderiaceae 28216|Betaproteobacteria C Ubiquinol oxidase, subunit I cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_465443_1 1121935.AQXX01000119_gene4803 2.03e-104 323.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1XMXM@135619|Oceanospirillales 135619|Oceanospirillales J Elongation factor G, domain IV - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_465443_2 1122135.KB893134_gene3970 1.84e-27 112.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2TTGI@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Major facilitator Superfamily aas - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_45375_1 667014.Thein_1286 6.18e-59 206.0 COG0653@1|root,COG0653@2|Bacteria,2GGR1@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_45376_1 314230.DSM3645_28187 3.62e-23 104.0 COG5659@1|root,COG5659@2|Bacteria,2IWRG@203682|Planctomycetes 203682|Planctomycetes L best DB hits BLAST gb AAD45539.1 - - - - - - - - - - - - DDE_5 k59_45401_1 640081.Dsui_2996 1.24e-47 169.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KV9Y@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_45401_2 243365.CV_0220 2.97e-20 88.2 COG0350@1|root,COG2207@1|root,COG0350@2|Bacteria,COG2207@2|Bacteria,1N2YQ@1224|Proteobacteria,2VIAK@28216|Betaproteobacteria,2KR22@206351|Neisseriales 206351|Neisseriales L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated - - 2.1.1.63 ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N k59_45412_1 367737.Abu_0678 1.69e-48 176.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2YND5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E asparagine - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_45430_1 340099.Teth39_0432 8.44e-66 218.0 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,42FA0@68295|Thermoanaerobacterales 186801|Clostridia E amino acid carrier protein agcS - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_45523_1 290398.Csal_2585 8.29e-122 362.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1XIAX@135619|Oceanospirillales 135619|Oceanospirillales H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_45523_2 1123368.AUIS01000025_gene1501 4.49e-64 201.0 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria,2NCVZ@225057|Acidithiobacillales 225057|Acidithiobacillales K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_45523_3 1179778.PMM47T1_02964 8.27e-61 199.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_45635_3 1338011.BD94_0634 4.6e-08 57.4 COG0175@1|root,COG0175@2|Bacteria 2|Bacteria EH sulfate reduction - - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_45670_1 1336235.JAEG01000004_gene3953 1.33e-21 98.6 COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,4B95Y@82115|Rhizobiaceae 28211|Alphaproteobacteria T GHKL domain - - 2.7.13.3 ko:K11711 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,Response_reg k59_45780_1 1379270.AUXF01000004_gene3268 3.73e-63 214.0 COG0370@1|root,COG0370@2|Bacteria,1ZT1I@142182|Gemmatimonadetes 142182|Gemmatimonadetes P transporter of a GTP-driven Fe(2 ) uptake system - - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_45882_1 1173022.Cri9333_4060 8.57e-24 100.0 COG0296@1|root,COG0296@2|Bacteria,1GD05@1117|Cyanobacteria,1HEAH@1150|Oscillatoriales 1117|Cyanobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position - - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_45882_2 909663.KI867150_gene118 4.08e-18 79.7 COG0296@1|root,COG0296@2|Bacteria,1NIZI@1224|Proteobacteria,42WYM@68525|delta/epsilon subdivisions,2WSNX@28221|Deltaproteobacteria,2MSG5@213462|Syntrophobacterales 28221|Deltaproteobacteria G PFAM glycoside hydrolase, family 13 domain protein - - - - - - - - - - - - AMPK1_CBM k59_45891_1 1382356.JQMP01000003_gene2210 6.85e-14 77.0 COG0463@1|root,COG1216@1|root,COG0463@2|Bacteria,COG1216@2|Bacteria,2G6JZ@200795|Chloroflexi,27XJJ@189775|Thermomicrobia 189775|Thermomicrobia M Glycosyl transferase family group 2 - - - ko:K07011 - - - - ko00000 - - - Glycos_transf_2 k59_45902_1 479434.Sthe_3486 1.78e-61 219.0 COG4867@1|root,COG4867@2|Bacteria,2G8A6@200795|Chloroflexi,27XPF@189775|Thermomicrobia 189775|Thermomicrobia S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_46268_2 388413.ALPR1_11615 1.85e-28 113.0 COG0405@1|root,COG0405@2|Bacteria,4NG3X@976|Bacteroidetes,47MKS@768503|Cytophagia 976|Bacteroidetes E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_46505_2 102107.XP_008243435.1 1.11e-09 61.2 COG1999@1|root,KOG2792@2759|Eukaryota,37M1T@33090|Viridiplantae,3G73D@35493|Streptophyta,4JHKA@91835|fabids 35493|Streptophyta C Protein SCO1 homolog 1 - GO:0000003,GO:0003006,GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006996,GO:0007005,GO:0007275,GO:0008150,GO:0008535,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0016043,GO:0017004,GO:0022414,GO:0022607,GO:0032501,GO:0032502,GO:0033108,GO:0033617,GO:0034622,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0061458,GO:0065003,GO:0071840 - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_46523_1 1148.1652013 9.2e-31 122.0 COG0438@1|root,COG0438@2|Bacteria,1G2H7@1117|Cyanobacteria,1H55U@1142|Synechocystis 1117|Cyanobacteria M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_46643_1 1232410.KI421418_gene2187 4.37e-122 353.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,42MNQ@68525|delta/epsilon subdivisions,2WJJW@28221|Deltaproteobacteria,43S2M@69541|Desulfuromonadales 28221|Deltaproteobacteria J Glycyl-tRNA synthetase alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF987.Gmet_2942 tRNA-synt_2e k59_46723_1 1229909.NSED_05330 1.92e-06 51.6 COG1378@1|root,arCOG02037@2157|Archaea,41T5N@651137|Thaumarchaeota 651137|Thaumarchaeota K transcriptional - - - - - - - - - - - - TrmB k59_46723_2 1229909.NSED_07370 5.38e-22 87.0 COG1522@1|root,arCOG01117@2157|Archaea 1229909.NSED_07370|- K COG1522 Transcriptional regulators - - - - - - - - - - - - - k59_46791_1 1207063.P24_11210 8.08e-82 250.0 COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,2TVMU@28211|Alphaproteobacteria,2JU2U@204441|Rhodospirillales 204441|Rhodospirillales I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit - - 2.8.3.12 ko:K01039 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_46890_1 488538.SAR116_2345 8.48e-14 67.4 2EMVQ@1|root,33FHY@2|Bacteria,1NNSC@1224|Proteobacteria,2UWDN@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_46890_3 238854.Q5GQA3_BPSYP 3.13e-57 192.0 4QCVC@10239|Viruses,4QV50@35237|dsDNA viruses no RNA stage,4QPN4@28883|Caudovirales,4QJSZ@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_47084_2 344747.PM8797T_16238 1.64e-242 691.0 COG0843@1|root,COG0843@2|Bacteria,2J2GN@203682|Planctomycetes 203682|Planctomycetes C Belongs to the heme-copper respiratory oxidase family - - - - - - - - - - - - COX1 k59_47175_1 43354.JOIJ01000027_gene3347 7.02e-25 109.0 COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4DZCT@85010|Pseudonocardiales 201174|Actinobacteria Q Belongs to the long-chain O-acyltransferase family tgs3 GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - DUF1298,WES_acyltransf k59_47293_1 864051.BurJ1DRAFT_3207 1.73e-18 84.3 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,2VQRJ@28216|Betaproteobacteria 28216|Betaproteobacteria M Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_47293_2 945550.VISI1226_11801 3.39e-13 67.4 COG3350@1|root,COG3350@2|Bacteria,1N0GC@1224|Proteobacteria,1S846@1236|Gammaproteobacteria,1XY38@135623|Vibrionales 135623|Vibrionales S YHS domain - - - - - - - - - - - - YHS k59_47380_1 321846.PS417_23595 1.73e-57 196.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RPIW@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q N-acyl-D-aspartate D-glutamate deacylase dan - 3.5.1.81,3.5.1.82 ko:K01461,ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 k59_47426_1 1232410.KI421421_gene3529 3.63e-70 239.0 COG2067@1|root,COG2885@1|root,COG2067@2|Bacteria,COG2885@2|Bacteria,1MY5K@1224|Proteobacteria 1224|Proteobacteria I long-chain fatty acid transport protein - - - - - - - - - - - - DUF11 k59_47505_1 990285.RGCCGE502_12074 9.81e-26 103.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTYY@28211|Alphaproteobacteria,4B8SE@82115|Rhizobiaceae 28211|Alphaproteobacteria S alcohol dehydrogenase adh - - ko:K13979 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_47860_1 1525715.IX54_05220 2.53e-135 406.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2PUKE@265|Paracoccus 28211|Alphaproteobacteria P E1-E2 ATPase actP - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_47901_1 436308.Nmar_1793 3.45e-52 175.0 COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_47901_2 436308.Nmar_1794 4.37e-66 223.0 COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC - 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - PolC_DP2 k59_47907_1 1267533.KB906736_gene1326 1.2e-37 135.0 COG2898@1|root,COG2898@2|Bacteria,3Y4M0@57723|Acidobacteria,2JJ8Z@204432|Acidobacteriia 204432|Acidobacteriia S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms - - - - - - - - - - - - - k59_47940_1 583345.Mmol_1435 2.06e-53 192.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,2KKKE@206350|Nitrosomonadales 206350|Nitrosomonadales D Ftsk_gamma - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_47945_1 2880.D8LSS8 8.73e-60 207.0 COG0265@1|root,KOG1421@2759|Eukaryota 2759|Eukaryota O serine-type endopeptidase activity DEG7 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009314,GO:0009416,GO:0009507,GO:0009536,GO:0009628,GO:0009642,GO:0009644,GO:0009892,GO:0010109,GO:0010205,GO:0016787,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0042548,GO:0043155,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043467,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0071704,GO:0140096,GO:1901564,GO:1905156 - - - - - - - - - - PDZ_1,PDZ_2,Trypsin_2 k59_156706_2 1121091.AUMP01000002_gene2092 1.41e-14 73.6 COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,4H9YE@91061|Bacilli 91061|Bacilli C Belongs to the citrate synthase family citZ - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_887989_1 483219.LILAB_21265 5.63e-40 143.0 COG1309@1|root,COG1309@2|Bacteria,1NQ0S@1224|Proteobacteria,43AGR@68525|delta/epsilon subdivisions,2WN8X@28221|Deltaproteobacteria,2YX94@29|Myxococcales 28221|Deltaproteobacteria K Bacterial regulatory proteins, tetR family - - - ko:K13770 - - - - ko00000,ko03000 - - - TetR_C_4,TetR_N k59_887989_2 1144275.COCOR_02554 6.61e-79 244.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NF6@68525|delta/epsilon subdivisions,2WKVH@28221|Deltaproteobacteria 28221|Deltaproteobacteria V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_417880_1 1121861.KB899918_gene3225 1.01e-93 284.0 COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2TTDT@28211|Alphaproteobacteria,2JVI9@204441|Rhodospirillales 204441|Rhodospirillales G D-galactarate dehydratase / Altronate hydrolase, C terminus - - - - - - - - - - - - GD_AH_C k59_522364_1 1536773.R70331_28830 9.13e-09 62.0 COG0438@1|root,COG1216@1|root,COG2227@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,COG2227@2|Bacteria,1TQTM@1239|Firmicutes,4I2GY@91061|Bacilli,26W7E@186822|Paenibacillaceae 91061|Bacilli M Glycosyltransferase like family - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_trans_1_4,Glycos_transf_2 k59_52256_1 330214.NIDE3770 3.23e-86 264.0 COG3173@1|root,COG3173@2|Bacteria 2|Bacteria S very-long-chain-acyl-CoA dehydrogenase activity - - - - - - - - - - - - APH k59_1410346_1 338963.Pcar_1239 1.67e-86 266.0 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,43TT3@69541|Desulfuromonadales 28221|Deltaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II - - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_365669_1 472759.Nhal_0363 4.44e-114 352.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1X28I@135613|Chromatiales 135613|Chromatiales M Lysin motif - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_1619284_1 436308.Nmar_1008 3.63e-80 259.0 COG0458@1|root,COG0624@1|root,arCOG01107@2157|Archaea,arCOG01596@2157|Archaea 2157|Archaea EF ATP-grasp domain cxp2 - 3.4.17.11,3.5.1.18,6.3.2.4 ko:K01295,ko:K01439,ko:K01921,ko:K16181 ko00300,ko00473,ko00550,ko01100,ko01120,ko01230,ko01502,map00300,map00473,map00550,map01100,map01120,map01230,map01502 M00016 R01150,R02734,R10011 RC00064,RC00090,RC00096,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011 - - - ATP-grasp_3,CPSase_L_D2,Dala_Dala_lig_C,M20_dimer,Peptidase_M20 k59_1201420_1 519989.ECTPHS_10946 6.45e-89 283.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_888016_1 330214.NIDE4318 6.01e-85 278.0 COG1197@1|root,COG1197@2|Bacteria,3J0BA@40117|Nitrospirae 40117|Nitrospirae L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_156720_1 1163617.SCD_n01160 2.95e-124 377.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria 28216|Betaproteobacteria E Extracellular solute-binding protein oppA - - - - - - - - - - - SBP_bac_5 k59_417893_1 1133850.SHJG_1262 6.57e-10 61.2 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_417893_2 1379281.AVAG01000012_gene1490 8.18e-158 469.0 COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,42NBI@68525|delta/epsilon subdivisions,2WM33@28221|Deltaproteobacteria,2MGD3@213115|Desulfovibrionales 28221|Deltaproteobacteria T Carbon starvation protein CstA cstA - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM k59_679088_1 436308.Nmar_1128 5.88e-48 163.0 COG0803@1|root,arCOG01005@2157|Archaea,41T29@651137|Thaumarchaeota 651137|Thaumarchaeota P Periplasmic solute binding protein - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_679088_2 1229909.NSED_08955 7.97e-107 312.0 COG1121@1|root,arCOG00201@2157|Archaea,41S7E@651137|Thaumarchaeota 651137|Thaumarchaeota E PFAM ABC transporter - - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran k59_1567054_1 3067.XP_002955713.1 1.11e-41 156.0 COG1372@1|root,2QRRC@2759|Eukaryota 2759|Eukaryota L reductase - GO:0003674,GO:0003824,GO:0004748,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009141,GO:0009142,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - Ribonuc_red_lgC k59_1096945_1 1343158.SACS_1541 5.73e-52 175.0 COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,2VFXH@28211|Alphaproteobacteria,2JQUE@204441|Rhodospirillales 204441|Rhodospirillales CE Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.41 ko:K00030 ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00709 RC00114 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_835784_2 1537917.JU82_10600 6.77e-15 74.3 COG0723@1|root,COG0723@2|Bacteria,1MZ7A@1224|Proteobacteria,42N9F@68525|delta/epsilon subdivisions,2YNBZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_1305896_1 394221.Mmar10_1145 5.77e-31 116.0 29KMP@1|root,307IZ@2|Bacteria,1REJ6@1224|Proteobacteria,2UAW7@28211|Alphaproteobacteria,43XXB@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF4287) - - - - - - - - - - - - DUF4287 k59_1410370_2 313612.L8106_02342 9.66e-22 94.4 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1GCZC@1117|Cyanobacteria,1HF41@1150|Oscillatoriales 1117|Cyanobacteria G PEP-utilising enzyme, TIM barrel domain - - - - - - - - - - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1149198_1 1173023.KE650771_gene564 2.21e-80 261.0 COG1404@1|root,COG1404@2|Bacteria,1G39Y@1117|Cyanobacteria 1117|Cyanobacteria O Subtilase family - - - - - - - - - - - - Peptidase_S8 k59_52288_1 519442.Huta_0024 1.84e-07 61.2 COG5013@1|root,arCOG01497@2157|Archaea,2XTNG@28890|Euryarchaeota,23TXI@183963|Halobacteria 183963|Halobacteria C Nitrate reductase alpha subunit narG - - ko:K17050 - - - - ko00000,ko02000 5.A.3.8 - - Molybdopterin,Molydop_binding k59_1044735_1 33876.JNXY01000006_gene1114 6.12e-21 97.1 COG5002@1|root,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4DGWR@85008|Micromonosporales 201174|Actinobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K07642 ko02020,map02020 M00450,M00645,M00646,M00648 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_1044735_2 1415780.JPOG01000001_gene3350 7.42e-12 65.9 COG4313@1|root,COG4313@2|Bacteria,1MXNW@1224|Proteobacteria,1S14R@1236|Gammaproteobacteria 1236|Gammaproteobacteria C hemolysin activation secretion protein - - - - - - - - - - - - DUF3570,Phenol_MetA_deg k59_313457_1 937777.Deipe_0055 1.76e-32 128.0 COG1820@1|root,COG1820@2|Bacteria,1WJGJ@1297|Deinococcus-Thermus 2|Bacteria G Belongs to the metallo-dependent hydrolases superfamily. NagA family nagA - 3.5.1.25 ko:K01443,ko:K16786,ko:K16787 ko00520,ko01130,ko02010,map00520,map01130,map02010 M00582 R02059 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - Amidohydro_1 k59_1567080_1 861299.J421_3227 1.94e-93 285.0 COG0334@1|root,COG0334@2|Bacteria,1ZSQB@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_1253681_1 305900.GV64_03800 1.29e-45 162.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XHFG@135619|Oceanospirillales 135619|Oceanospirillales T regulator hydG - - - - - - - - - - - Response_reg,Sigma54_activat k59_52298_1 266117.Rxyl_0919 1.39e-62 207.0 COG1144@1|root,COG1144@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor porD GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575 1.2.7.1,1.2.7.10 ko:K00171,ko:K00172,ko:K19072 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_10,Fer4_21,POR k59_574636_2 1123279.ATUS01000004_gene2814 1.23e-49 176.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,1J5AG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1462618_1 1415780.JPOG01000001_gene3152 7.21e-89 274.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,1RNDU@1236|Gammaproteobacteria,1XABV@135614|Xanthomonadales 135614|Xanthomonadales I Thiolase, C-terminal domain - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_1462618_2 1348657.M622_04415 9.38e-15 73.9 COG0318@1|root,COG0318@2|Bacteria,1MWSD@1224|Proteobacteria,2VR64@28216|Betaproteobacteria 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.48 ko:K02182 - - - - ko00000,ko01000 - - - AMP-binding,AMP-binding_C k59_1623804_1 105559.Nwat_0872 3.17e-137 407.0 COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,1X0IX@135613|Chromatiales 135613|Chromatiales S PFAM peptidase S15 - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_684563_2 330214.NIDE2666 1.81e-18 80.5 COG2096@1|root,COG2096@2|Bacteria 2|Bacteria S cob(I)yrinic acid a,c-diamide adenosyltransferase activity yvqK GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.2.1.88,1.5.5.2,2.5.1.17 ko:K00798,ko:K13821 ko00250,ko00330,ko00860,ko01100,ko01110,ko01130,map00250,map00330,map00860,map01100,map01110,map01130 M00122 R00245,R00707,R00708,R01253,R01492,R04444,R04445,R05051,R05220,R07268 RC00080,RC00083,RC00216,RC00242,RC00255,RC00533 ko00000,ko00001,ko00002,ko01000,ko03000 - - - Cob_adeno_trans k59_579068_1 396588.Tgr7_0112 1.38e-22 92.0 COG4319@1|root,COG4319@2|Bacteria,1NEUY@1224|Proteobacteria,1S6AP@1236|Gammaproteobacteria,1WYK1@135613|Chromatiales 135613|Chromatiales S SnoaL-like domain - - - - - - - - - - - - SnoaL_3 k59_579068_2 754476.Q7A_873 1.68e-82 265.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,460ES@72273|Thiotrichales 72273|Thiotrichales MU type I secretion outer membrane protein, TolC - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_996576_1 316274.Haur_1148 2.96e-44 162.0 COG0058@1|root,COG0058@2|Bacteria,2G5KG@200795|Chloroflexi,37562@32061|Chloroflexia 32061|Chloroflexia G PFAM glycosyl transferase, family 35 - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_632449_1 246197.MXAN_2513 1.66e-61 207.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2YUKY@29|Myxococcales 28221|Deltaproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1207065_1 1177154.Y5S_03146 4.28e-08 60.8 COG1572@1|root,COG1572@2|Bacteria,1QVRG@1224|Proteobacteria 1224|Proteobacteria G PFAM SMP-30 Gluconolaconase - - - ko:K20952 ko05111,map05111 - - - ko00000,ko00001 - - - Beta-prism_lec,Calx-beta,DUF5122 k59_1467376_1 264462.Bd3869 1.47e-46 170.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42N0H@68525|delta/epsilon subdivisions,2MSU2@213481|Bdellovibrionales,2WIYD@28221|Deltaproteobacteria 213481|Bdellovibrionales S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_632451_1 316067.Geob_2597 2.83e-17 87.8 COG0768@1|root,COG0768@2|Bacteria,1R7A0@1224|Proteobacteria,42MJC@68525|delta/epsilon subdivisions,2WJZ2@28221|Deltaproteobacteria 28221|Deltaproteobacteria M penicillin-binding protein pbp4 - - - - - - - - - - - Transpeptidase k59_57789_1 223283.PSPTO_3922 7.63e-35 135.0 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria,1Z6BC@136849|Pseudomonas syringae group 1236|Gammaproteobacteria J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides rnd GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0033890,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_1414727_1 1397666.RS24_01075 4.2e-132 388.0 COG1473@1|root,COG1473@2|Bacteria,1MX6N@1224|Proteobacteria,2TRSE@28211|Alphaproteobacteria 28211|Alphaproteobacteria S amidohydrolase abgB - - ko:K12941 - - - - ko00000,ko01002 - - - M20_dimer,Peptidase_M20 k59_1571263_1 1265490.JHVY01000013_gene1044 2.62e-42 152.0 COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_1153606_1 330214.NIDE3729 7.97e-93 284.0 COG0612@1|root,COG0612@2|Bacteria,3J0BY@40117|Nitrospirae 40117|Nitrospirae S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_57800_1 745014.OMB55_00019940 5.48e-53 195.0 COG3391@1|root,COG3391@2|Bacteria,1R66T@1224|Proteobacteria 1224|Proteobacteria C amine dehydrogenase activity - - - - - - - - - - - - Lactonase k59_422431_1 765910.MARPU_09105 1.19e-24 105.0 COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,1RM9Z@1236|Gammaproteobacteria,1WX87@135613|Chromatiales 135613|Chromatiales S PFAM Paraquat-inducible protein A - - - ko:K03808 - - - - ko00000 - - - PqiA k59_422431_2 1454004.AW11_02389 1.1e-27 106.0 COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,2VMXT@28216|Betaproteobacteria,1KQQZ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S Paraquat-inducible protein A pqiA - - ko:K03808 - - - - ko00000 - - - PqiA k59_1153620_1 1122247.C731_4072 7.49e-55 183.0 COG1575@1|root,COG1575@2|Bacteria,2IPQ8@201174|Actinobacteria,23E29@1762|Mycobacteriaceae 201174|Actinobacteria H Belongs to the MenA family. Type 1 subfamily - - - - - - - - - - - - UbiA k59_840331_1 102129.Lepto7375DRAFT_7743 1.65e-15 89.7 COG2931@1|root,COG3210@1|root,COG4995@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4995@2|Bacteria,1G08N@1117|Cyanobacteria,1H96Q@1150|Oscillatoriales 1117|Cyanobacteria U filamentous hemagglutinin family N-terminal domain - - - - - - - - - - - - CHAT,Haemagg_act k59_944383_1 1170562.Cal6303_4953 1.9e-23 99.4 COG0606@1|root,COG0606@2|Bacteria,1G0K1@1117|Cyanobacteria,1HIXF@1161|Nostocales 1117|Cyanobacteria O PFAM Magnesium chelatase, subunit ChlI comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_57816_1 1385517.N800_01155 6.03e-50 169.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1X56M@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_1310231_1 1286093.C266_06434 4.07e-25 103.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,1K4KX@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_38,rve k59_265788_1 572477.Alvin_1910 2.88e-119 367.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1WWWW@135613|Chromatiales 135613|Chromatiales CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_1362718_1 1229909.NSED_09130 3.28e-156 444.0 COG1522@1|root,arCOG01586@2157|Archaea,41T3N@651137|Thaumarchaeota 651137|Thaumarchaeota K AsnC-type helix-turn-helix domain - - - - - - - - - - - - HTH_24 k59_1154335_1 519989.ECTPHS_01174 9.31e-56 194.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_8 k59_1310927_1 472759.Nhal_3151 6.18e-44 157.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WXFD@135613|Chromatiales 135613|Chromatiales P PFAM Cation - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1310927_2 1283300.ATXB01000001_gene2074 3.64e-56 185.0 COG0569@1|root,COG0569@2|Bacteria,1RDDX@1224|Proteobacteria,1S3ZR@1236|Gammaproteobacteria,1XGZD@135618|Methylococcales 135618|Methylococcales P TrkA-N domain - - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_N k59_109234_1 426117.M446_5163 4.86e-25 100.0 COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,2U7AP@28211|Alphaproteobacteria,1JUUG@119045|Methylobacteriaceae 28211|Alphaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family MA20_28295 - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_1571966_1 1120973.AQXL01000118_gene483 3.07e-117 348.0 COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,4HAN7@91061|Bacilli 91061|Bacilli M Nad-dependent epimerase dehydratase ytcB - - - - - - - - - - - Epimerase,GDP_Man_Dehyd k59_789943_1 1415754.JQMK01000005_gene1714 2.49e-22 96.7 COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,469B0@72275|Alteromonadaceae 1236|Gammaproteobacteria I Methylmalonyl-CoA mutase scpA GO:0003674,GO:0003824,GO:0004494,GO:0005488,GO:0008144,GO:0016853,GO:0016866,GO:0019842,GO:0031419,GO:0036094,GO:0046906,GO:0048037,GO:0097159,GO:1901363 5.4.99.2,5.4.99.63 ko:K01847,ko:K01848,ko:K14447 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833,R09292 RC00395,RC02835 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_3653,iECO26_1355.ECO26_4004 B12-binding,MM_CoA_mutase k59_789943_2 639283.Snov_2771 1.1e-90 278.0 COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2TS96@28211|Alphaproteobacteria,3F0BW@335928|Xanthobacteraceae 28211|Alphaproteobacteria E TIGRFAM LAO AO transport system ATPase - - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k59_1468290_1 1144275.COCOR_02529 2.08e-76 260.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2YU45@29|Myxococcales 28221|Deltaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_266467_1 658655.HMPREF0988_00055 1.96e-24 98.6 COG1943@1|root,COG1943@2|Bacteria,1V9QQ@1239|Firmicutes,24K68@186801|Clostridia,27MSN@186928|unclassified Lachnospiraceae 186801|Clostridia L Transposase IS200 like - - - - - - - - - - - - Y1_Tnp k59_1363350_1 436308.Nmar_0731 1.5e-41 140.0 arCOG08757@1|root,arCOG08757@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_423093_1 228410.NE0569 2.92e-111 338.0 COG0260@1|root,COG0260@2|Bacteria,1MXP6@1224|Proteobacteria,2VJ0K@28216|Betaproteobacteria,372DH@32003|Nitrosomonadales 28216|Betaproteobacteria E PFAM Peptidase M17, leucyl aminopeptidase - - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17 k59_789957_1 1283299.AUKG01000002_gene3973 2.89e-74 237.0 COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4CPSQ@84995|Rubrobacteria 84995|Rubrobacteria I Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1468297_2 67356.KL575630_gene2332 1.63e-67 234.0 COG0153@1|root,COG1087@1|root,COG0153@2|Bacteria,COG1087@2|Bacteria,2GMCW@201174|Actinobacteria 201174|Actinobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_1468297_3 1150600.ADIARSV_1482 2.45e-18 89.0 COG0265@1|root,COG0265@2|Bacteria,4NFCS@976|Bacteroidetes,1INQ7@117747|Sphingobacteriia 976|Bacteroidetes O COGs COG0265 Trypsin-like serine protease typically periplasmic contain C-terminal PDZ domain - - - - - - - - - - - - PDZ_2,Trypsin_2 k59_160288_1 1123517.JOMR01000001_gene733 3.53e-38 136.0 COG0483@1|root,COG0483@2|Bacteria,1NFR1@1224|Proteobacteria,1S31N@1236|Gammaproteobacteria,460FD@72273|Thiotrichales 72273|Thiotrichales G Inositol monophosphatase - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_997387_1 1961.JOAK01000006_gene4703 1.14e-28 117.0 COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria 201174|Actinobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_58725_1 290398.Csal_3005 1.15e-24 99.4 COG0789@1|root,COG0789@2|Bacteria,1RJD4@1224|Proteobacteria,1S8DH@1236|Gammaproteobacteria,1XKGY@135619|Oceanospirillales 135619|Oceanospirillales K Transcriptional - - - - - - - - - - - - MerR,MerR-DNA-bind,MerR_1 k59_2725_1 351348.Maqu_3743 2.8e-69 218.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,464GZ@72275|Alteromonadaceae 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes rpoH GO:0000150,GO:0000976,GO:0000984,GO:0000985,GO:0000988,GO:0000990,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006310,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009009,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031421,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2001141 - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_579820_1 706587.Desti_1073 6.67e-26 111.0 COG1012@1|root,COG1012@2|Bacteria,1MV2I@1224|Proteobacteria,42R7M@68525|delta/epsilon subdivisions,2WMUH@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Succinylglutamic semialdehyde dehydrogenase astD - 1.2.1.71 ko:K06447 ko00330,ko01100,map00330,map01100 - R05049 RC00080 ko00000,ko00001,ko01000 - - - Aldedh k59_997400_1 330214.NIDE3281 3.8e-145 415.0 2AKTZ@1|root,31BM1@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_945074_1 323848.Nmul_A0851 9.34e-30 120.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,372DM@32003|Nitrosomonadales 28216|Betaproteobacteria M Outer membrane efflux protein - - - ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 - - OEP k59_945074_2 880072.Desac_2385 5.01e-63 216.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Hydrophobe amphiphile Efflux-1 (HAE1) family bepE - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_633401_1 1115515.EV102420_13_01010 3.41e-19 92.4 COG0849@1|root,COG0849@2|Bacteria,1PPIT@1224|Proteobacteria,1TKEP@1236|Gammaproteobacteria,3XM3U@561|Escherichia 1236|Gammaproteobacteria D MutL protein - - - - - - - - - - - - MutL k59_1363378_1 1283299.AUKG01000002_gene4852 0.000224 49.3 COG1266@1|root,COG1266@2|Bacteria 2|Bacteria V CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi k59_160306_1 398525.KB900701_gene4968 1.31e-105 329.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,3JQNW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.54 ko:K17686,ko:K19597 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5,3.A.3.5.20 - - E1-E2_ATPase,HMA,Hydrolase k59_633414_1 1144275.COCOR_07930 2.12e-23 97.4 COG3000@1|root,COG3000@2|Bacteria,1R4RM@1224|Proteobacteria,43F3R@68525|delta/epsilon subdivisions,2X3A7@28221|Deltaproteobacteria,2YV37@29|Myxococcales 28221|Deltaproteobacteria I fatty acid hydroxylase - - - - - - - - - - - - FA_hydroxylase k59_633414_2 857087.Metme_0732 7.45e-15 77.4 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2206 HD-GYP domain - - - - - - - - - - - - DUF3391,HD,HD_5 k59_685515_1 1177154.Y5S_00555 3.14e-31 122.0 COG1129@1|root,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,1T1GD@1236|Gammaproteobacteria 1236|Gammaproteobacteria V (ABC) transporter ybhF - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_685515_2 450851.PHZ_p0153 1.92e-75 242.0 COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,2TW9Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria V secretion protein yhiI - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1260221_2 566466.NOR53_3686 2.05e-32 124.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,1RQ3D@1236|Gammaproteobacteria,1JA8Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG1541 Coenzyme F390 synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C_2 k59_475258_1 436308.Nmar_1104 1.29e-36 138.0 COG0178@1|root,arCOG04694@2157|Archaea,41T01@651137|Thaumarchaeota 651137|Thaumarchaeota L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_475258_2 330214.NIDE2069 3.12e-21 84.7 arCOG12353@1|root,33KP1@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_633420_1 469383.Cwoe_2289 3.99e-77 256.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,2GM65@201174|Actinobacteria,4CS56@84995|Rubrobacteria 84995|Rubrobacteria EI ArgK protein - - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_841055_2 1469245.JFBG01000038_gene1817 9.05e-58 201.0 COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,1T214@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - DUF3306,Fer4,Fer4_10,Fer4_6,Fer4_7 k59_1208121_1 1122917.KB899663_gene2647 9.61e-06 53.1 COG2972@1|root,COG2972@2|Bacteria,1TQZQ@1239|Firmicutes,4HCX2@91061|Bacilli,26S21@186822|Paenibacillaceae 91061|Bacilli T Histidine kinase - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,His_kinase,dCache_1 k59_475268_1 1123277.KB893174_gene5974 4.03e-21 97.8 COG0457@1|root,COG0823@1|root,COG2885@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,47MTM@768503|Cytophagia 976|Bacteroidetes MU Belongs to the ompA family - - - - - - - - - - - - OmpA,PD40,TPR_16,TPR_2,TPR_8 k59_1572028_1 1126627.BAWE01000004_gene2380 7.25e-66 213.0 COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2TUPH@28211|Alphaproteobacteria,3JRRW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1102341_1 716544.wcw_1593 3.33e-208 591.0 COG1274@1|root,COG1274@2|Bacteria,2JFEW@204428|Chlamydiae 204428|Chlamydiae F Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_475270_1 1037410.MCSF7_01676 3.6e-15 82.4 COG0305@1|root,COG0305@2|Bacteria,3WT5F@544448|Tenericutes 544448|Tenericutes L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_893470_1 436308.Nmar_1795 9.39e-41 140.0 COG1646@1|root,arCOG01085@2157|Archaea,41SH4@651137|Thaumarchaeota 651137|Thaumarchaeota H Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids - - 2.5.1.41 ko:K17104 ko00564,map00564 - R04158 RC01091 ko00000,ko00001,ko01000 - - - PcrB k59_893470_2 436308.Nmar_1794 1.86e-37 139.0 COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC - 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - PolC_DP2 k59_160315_1 1131553.JIBI01000046_gene1600 3.76e-90 281.0 COG2855@1|root,COG2855@2|Bacteria 2|Bacteria P membrane - - - - - - - - - - - - Cons_hypoth698 k59_997436_1 1267534.KB906754_gene2902 3.23e-49 169.0 COG0628@1|root,COG0628@2|Bacteria,3Y6VE@57723|Acidobacteria,2JK9F@204432|Acidobacteriia 204432|Acidobacteriia S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_58790_1 444861.E3SPQ0_9CAUD 3.14e-22 87.4 4QGC6@10239|Viruses,4QRN9@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_423149_1 1463861.JNXE01000021_gene4244 1.3e-20 95.5 COG0604@1|root,COG0604@2|Bacteria,2GMHR@201174|Actinobacteria 201174|Actinobacteria C alcohol dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_1154430_2 1121468.AUBR01000002_gene665 2.32e-26 102.0 COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,24MQ3@186801|Clostridia,42H28@68295|Thermoanaerobacterales 186801|Clostridia K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_1415604_4 1463895.JODA01000019_gene7286 2.3e-34 133.0 COG2192@1|root,COG2192@2|Bacteria,2GJHV@201174|Actinobacteria 201174|Actinobacteria O Carbamoyltransferase - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_272880_2 404589.Anae109_2030 6.12e-70 233.0 COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,43CC6@68525|delta/epsilon subdivisions,2X7N2@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA k59_798541_2 1336233.JAEH01000076_gene624 9.1e-26 103.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria,2Q9X3@267890|Shewanellaceae 1236|Gammaproteobacteria K PFAM regulatory protein LuxR uvrY GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007 - ko:K07689 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_899805_1 485917.Phep_2026 2.02e-06 55.1 COG1134@1|root,COG1134@2|Bacteria,4NEDM@976|Bacteroidetes,1IV64@117747|Sphingobacteriia 976|Bacteroidetes GM ATPases associated with a variety of cellular activities - - - ko:K09691 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC_tran,Wzt_C k59_1215585_1 288000.BBta_7133 9.54e-96 290.0 COG0625@1|root,COG0625@2|Bacteria,1Q9ND@1224|Proteobacteria,2TT22@28211|Alphaproteobacteria,3JX9Z@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Glutathione S-transferase, C-terminal domain - - - - - - - - - - - - GST_C_2,GST_N_3 k59_1215585_2 172088.AUGA01000021_gene5232 3.47e-15 74.7 2DB8I@1|root,2Z7RY@2|Bacteria,1MY4M@1224|Proteobacteria,2U2A8@28211|Alphaproteobacteria,3JTM4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1215586_1 1049564.TevJSym_bk00050 9.03e-44 149.0 COG2236@1|root,COG2236@2|Bacteria,1RKB0@1224|Proteobacteria,1S7J1@1236|Gammaproteobacteria,1JBAT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Phosphoribosyl transferase domain - - - - - - - - - - - - Pribosyltran k59_1422780_1 493475.GARC_4342 7.2e-22 92.0 296FD@1|root,2ZTQZ@2|Bacteria,1PAEW@1224|Proteobacteria,1SVB6@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1422780_2 485915.Dret_1975 8.76e-26 107.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2WJTY@28221|Deltaproteobacteria,2MG38@213115|Desulfovibrionales 28221|Deltaproteobacteria L UvrD-like helicase C-terminal domain - - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_272891_1 1397528.Q671_07025 4.62e-68 216.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1XH44@135619|Oceanospirillales 135619|Oceanospirillales I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_325611_1 292415.Tbd_0221 8.01e-83 254.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2VH6N@28216|Betaproteobacteria,1KRVI@119069|Hydrogenophilales 119069|Hydrogenophilales H Quinolinate synthetase A protein - - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_1578080_1 1229909.NSED_09265 7.71e-31 119.0 arCOG08768@1|root,arCOG08768@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1578080_2 436308.Nmar_1742 9.26e-19 77.0 arCOG07262@1|root,arCOG07262@2157|Archaea,41T8B@651137|Thaumarchaeota 651137|Thaumarchaeota S IMP dehydrogenase activity - - - - - - - - - - - - - k59_1476326_1 1229909.NSED_02595 8.85e-107 312.0 COG0396@1|root,arCOG04236@2157|Archaea,41SE1@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly ATPase SufC - - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_220533_1 1095769.CAHF01000014_gene2868 6.9e-46 159.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VISB@28216|Betaproteobacteria,472TI@75682|Oxalobacteraceae 28216|Betaproteobacteria I PFAM Carbamoyl-phosphate synthase L chain, ATP binding domain, Biotin carboxylase C-terminal domain, Carbamoyl-phosphate synthase L chain, N-terminal domain accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_220533_2 1288494.EBAPG3_9440 6.61e-38 130.0 COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2VR5S@28216|Betaproteobacteria,3737Q@32003|Nitrosomonadales 28216|Betaproteobacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl k59_377463_1 909663.KI867150_gene885 4.06e-90 294.0 COG0574@1|root,COG1669@1|root,COG0574@2|Bacteria,COG1669@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,2MR7X@213462|Syntrophobacterales 28221|Deltaproteobacteria H Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - - - - - - - - - - NTP_transf_2,PPDK_N k59_798571_1 404589.Anae109_3367 5.8e-16 73.6 COG4911@1|root,COG4911@2|Bacteria,1QCSX@1224|Proteobacteria,4387P@68525|delta/epsilon subdivisions,2X3HG@28221|Deltaproteobacteria,2YW4D@29|Myxococcales 28221|Deltaproteobacteria S Uncharacterized conserved protein (DUF2203) - - - - - - - - - - - - DUF2203 k59_798571_2 7091.BGIBMGA002043-TA 4.12e-13 73.9 KOG3689@1|root,KOG3689@2759|Eukaryota,38BQB@33154|Opisthokonta,3B9XB@33208|Metazoa,3CSEF@33213|Bilateria,41TI4@6656|Arthropoda,3SFSY@50557|Insecta,4452F@7088|Lepidoptera 33208|Metazoa T GAF domain - GO:0000302,GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0006935,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0007275,GO:0007568,GO:0007602,GO:0007610,GO:0007635,GO:0008081,GO:0008150,GO:0008340,GO:0009268,GO:0009314,GO:0009416,GO:0009581,GO:0009582,GO:0009583,GO:0009605,GO:0009628,GO:0009636,GO:0009893,GO:0009966,GO:0009968,GO:0009987,GO:0010035,GO:0010259,GO:0010446,GO:0010468,GO:0010604,GO:0010628,GO:0010646,GO:0010648,GO:0010752,GO:0010754,GO:0016043,GO:0016787,GO:0016788,GO:0019222,GO:0023051,GO:0023052,GO:0023057,GO:0030030,GO:0032501,GO:0032502,GO:0032528,GO:0040011,GO:0042221,GO:0042330,GO:0042493,GO:0042542,GO:0042578,GO:0046677,GO:0047555,GO:0048518,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051606,GO:0051716,GO:0060255,GO:0065007,GO:0071840,GO:0120036,GO:1901700,GO:1902531,GO:1902532 3.1.4.17,3.1.4.35 ko:K18438 ko00230,ko05032,map00230,map05032 - R00191,R01234 RC00296 ko00000,ko00001,ko01000 - - - GAF,PDEase_I k59_1268316_1 1479238.JQMZ01000001_gene1493 1.85e-10 67.4 2ECN7@1|root,31C3K@2|Bacteria,1Q81Z@1224|Proteobacteria,2V92U@28211|Alphaproteobacteria,4406R@69657|Hyphomonadaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1476341_1 1206726.BAFV01000121_gene6086 2.78e-35 134.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4FU3N@85025|Nocardiaceae 201174|Actinobacteria C transferase - - 2.8.3.16,2.8.3.19 ko:K07749,ko:K18702 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_1056515_1 323848.Nmul_A0571 5.87e-26 104.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2VHPY@28216|Betaproteobacteria,371NK@32003|Nitrosomonadales 28216|Betaproteobacteria J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_1056515_2 264732.Moth_0971 9.79e-34 120.0 COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,24J83@186801|Clostridia,42GJ8@68295|Thermoanaerobacterales 186801|Clostridia J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_1268323_1 1214242.B446_09480 6.75e-45 159.0 COG2159@1|root,COG2159@2|Bacteria,2GP2D@201174|Actinobacteria 201174|Actinobacteria S amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_482620_1 517417.Cpar_1101 7.64e-67 224.0 COG1022@1|root,COG1022@2|Bacteria,1FDU1@1090|Chlorobi 1090|Chlorobi I PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_951283_1 65497.JODV01000001_gene3930 8.25e-50 171.0 COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4E0UJ@85010|Pseudonocardiales 201174|Actinobacteria IQ short chain dehydrogenase - - - - - - - - - - - - adh_short k59_272921_1 1123236.KB899389_gene2201 1.49e-24 98.2 COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,1S93F@1236|Gammaproteobacteria,467HC@72275|Alteromonadaceae 1236|Gammaproteobacteria S Thioesterase-like superfamily ybgC GO:0003674,GO:0003824,GO:0016787,GO:0016788,GO:0016790 3.1.2.23 ko:K01075,ko:K07107 ko00130,ko00362,ko01100,ko01110,ko01120,map00130,map00362,map01100,map01110,map01120 - R01301 RC00004,RC00174 ko00000,ko00001,ko01000 - - iECP_1309.ECP_0747,iSDY_1059.SDY_0684 4HBT k59_1108801_1 9315.ENSMEUP00000005342 1.01e-50 179.0 KOG1179@1|root,KOG1179@2759|Eukaryota,38B7F@33154|Opisthokonta,3BA3X@33208|Metazoa,3CRF3@33213|Bilateria,483GM@7711|Chordata,48Y9M@7742|Vertebrata,3JBFJ@40674|Mammalia,4JX6B@9263|Metatheria 33208|Metazoa I Solute carrier family 27 (fatty acid transporter), member 5 SLC27A5 GO:0000038,GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0005215,GO:0005319,GO:0005342,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006638,GO:0006639,GO:0006641,GO:0006642,GO:0006694,GO:0006699,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0008028,GO:0008150,GO:0008152,GO:0008202,GO:0008206,GO:0008509,GO:0008514,GO:0008610,GO:0009058,GO:0009925,GO:0009987,GO:0010876,GO:0012505,GO:0015075,GO:0015245,GO:0015318,GO:0015645,GO:0015711,GO:0015718,GO:0015721,GO:0015849,GO:0015850,GO:0015908,GO:0015909,GO:0015911,GO:0016020,GO:0016021,GO:0016053,GO:0016323,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0017144,GO:0019752,GO:0022857,GO:0030176,GO:0031224,GO:0031227,GO:0031957,GO:0031984,GO:0032787,GO:0032991,GO:0033036,GO:0034220,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044877,GO:0045178,GO:0046394,GO:0046486,GO:0046942,GO:0046943,GO:0046950,GO:0046951,GO:0047747,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071944,GO:0072330,GO:0098590,GO:0098656,GO:0098827,GO:1901360,GO:1901362,GO:1901568,GO:1901570,GO:1901576,GO:1901615,GO:1901617,GO:1902001,GO:1902224,GO:1903825,GO:1905039 6.2.1.3,6.2.1.7 ko:K08746,ko:K08748,ko:K08749 ko00120,ko01100,ko03320,ko04146,ko04931,ko04976,map00120,map01100,map03320,map04146,map04931,map04976 M00104,M00106 R02794,R04507,R04580,R08733,R08738,R08743 RC00004,RC00014,RC00137 ko00000,ko00001,ko00002,ko01000,ko01004,ko02000 4.C.1.1,4.C.1.1.5,4.C.1.1.8 - - AMP-binding,AMP-binding_C k59_1215633_1 292415.Tbd_0013 5.78e-24 102.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria,1KSSH@119069|Hydrogenophilales 119069|Hydrogenophilales S Lysin motif - - - - - - - - - - - - LysM k59_1631196_1 1123248.KB893320_gene3898 3.01e-29 116.0 COG0277@1|root,COG0277@2|Bacteria,4NHFC@976|Bacteroidetes 976|Bacteroidetes C Berberine and berberine like - - - - - - - - - - - - BBE,DUF805,FAD_binding_4 k59_1056532_1 1541065.JRFE01000017_gene17 1.8e-15 79.0 COG0282@1|root,COG0282@2|Bacteria,1G214@1117|Cyanobacteria,3VJAG@52604|Pleurocapsales 1117|Cyanobacteria C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_742647_1 1229909.NSED_00705 2.05e-97 295.0 COG1257@1|root,arCOG04260@2157|Archaea,41SAU@651137|Thaumarchaeota 651137|Thaumarchaeota I Belongs to the HMG-CoA reductase family - - 1.1.1.88 ko:K00054 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R02081 RC00004,RC00644 ko00000,ko00001,ko01000 - - - HMG-CoA_red k59_1578126_1 472759.Nhal_3944 2.17e-66 218.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1WWG8@135613|Chromatiales 135613|Chromatiales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_1108813_1 550540.Fbal_1407 0.000185 47.8 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella mltF2 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_1108813_3 715226.ABI_07810 1.95e-48 169.0 COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TSD9@28211|Alphaproteobacteria,2KG6K@204458|Caulobacterales 204458|Caulobacterales K Transcriptional regulator, LysR family - - - ko:K03566 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_586125_1 1122947.FR7_4292 8.33e-46 163.0 COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,4H31M@909932|Negativicutes 909932|Negativicutes C Part of a membrane complex involved in electron transport rnfC - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4,Fer4_10,Fer4_4,Fer4_8,RnfC_N,SLBB k59_586125_2 1049564.TevJSym_aq00700 2.65e-25 105.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,1J55P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport rnfD - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_1476395_1 1056816.JAFQ01000004_gene6300 7.45e-30 120.0 COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4FX82@85025|Nocardiaceae 201174|Actinobacteria S ABC1 family - - - - - - - - - - - - ABC1 k59_533712_1 1283300.ATXB01000001_gene1150 1.04e-60 199.0 COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,1RM7T@1236|Gammaproteobacteria,1XE2G@135618|Methylococcales 135618|Methylococcales E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metAS GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0008899,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - HTS k59_533712_2 909663.KI867150_gene243 9.86e-10 58.9 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,42M67@68525|delta/epsilon subdivisions,2WJQX@28221|Deltaproteobacteria,2MQ8M@213462|Syntrophobacterales 28221|Deltaproteobacteria E PFAM Cys Met metabolism metC-2 - 4.4.1.11,4.4.1.8 ko:K01760,ko:K01761 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R00654,R00782,R01286,R02408,R04770,R04941 RC00056,RC00069,RC00196,RC00348,RC00382,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_951317_2 999541.bgla_1g29270 4.01e-62 196.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2VHHV@28216|Betaproteobacteria,1K15D@119060|Burkholderiaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_1160093_1 161934.XP_010684042.1 1.5e-125 379.0 COG0124@1|root,KOG1936@2759|Eukaryota,37QT9@33090|Viridiplantae,3GGEC@35493|Streptophyta 35493|Streptophyta J histidine--tRNA ligase - GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009536,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_1160093_2 1385517.N800_05850 6.41e-21 92.8 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,1X30I@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the biosynthesis of agmatine from arginine speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_1422884_1 436308.Nmar_1567 2.83e-89 268.0 COG0077@1|root,arCOG00255@2157|Archaea,41SA8@651137|Thaumarchaeota 651137|Thaumarchaeota E Prephenate dehydratase - - 4.2.1.51 ko:K04518 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024 R00691,R01373 RC00360 ko00000,ko00001,ko00002,ko01000 - - - ACT,PDT k59_220604_1 880072.Desac_1949 3.09e-26 108.0 COG2197@1|root,COG2203@1|root,COG4191@1|root,COG2197@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MRI2@213462|Syntrophobacterales 28221|Deltaproteobacteria T Signal transduction response regulator, receiver domain - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,PocR,Response_reg,dCache_1,sCache_2 k59_220604_2 1030157.AFMP01000036_gene2661 3.45e-10 58.9 COG0698@1|root,COG0698@2|Bacteria,1RHBF@1224|Proteobacteria,2U94R@28211|Alphaproteobacteria,2K4KN@204457|Sphingomonadales 204457|Sphingomonadales G Ribose 5-phosphate isomerase rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_1476416_1 1121861.KB899935_gene437 8.26e-22 99.0 COG2114@1|root,COG2114@2|Bacteria,1RBTC@1224|Proteobacteria,2TWUX@28211|Alphaproteobacteria,2JURE@204441|Rhodospirillales 204441|Rhodospirillales T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - GAF,Guanylate_cyc,dCache_1 k59_533728_2 387093.SUN_1058 1.92e-31 124.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,42QA8@68525|delta/epsilon subdivisions,2YNH6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA,AAA_3 k59_272965_1 1231391.AMZF01000014_gene2393 1.23e-61 202.0 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2VHMU@28216|Betaproteobacteria,3T3QN@506|Alcaligenaceae 28216|Betaproteobacteria O DnaJ C terminal domain cbpA - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_951333_1 525378.HMPREF0793_1393 0.000112 50.8 COG1368@1|root,COG1368@2|Bacteria,1TRMA@1239|Firmicutes,4H9S0@91061|Bacilli,4GXQ0@90964|Staphylococcaceae 91061|Bacilli M Catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, a reaction that presumably uses phosphatidylglycerol (PG) as substrate ltaS GO:0005575,GO:0005576 2.7.8.20 ko:K19005 ko00561,ko01100,map00561,map01100 - R05081,R10849 RC00017 ko00000,ko00001,ko01000 - - - Sulfatase k59_847429_1 404589.Anae109_3226 2.5e-74 243.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,43C63@68525|delta/epsilon subdivisions,2WTQK@28221|Deltaproteobacteria,2YXI2@29|Myxococcales 28221|Deltaproteobacteria P ABC transporter transmembrane region msbA9 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_377529_1 596151.DesfrDRAFT_2790 7.48e-37 144.0 COG4262@1|root,COG4262@2|Bacteria,1QX9D@1224|Proteobacteria,42Q62@68525|delta/epsilon subdivisions,2WMHX@28221|Deltaproteobacteria,2M99V@213115|Desulfovibrionales 28221|Deltaproteobacteria E Spermine/spermidine synthase domain - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_1268397_1 1313172.YM304_04480 6.29e-05 45.1 COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4CNJI@84992|Acidimicrobiia 84992|Acidimicrobiia C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1268397_2 196162.Noca_0232 1.12e-15 79.3 COG3427@1|root,COG3427@2|Bacteria,2GKTQ@201174|Actinobacteria,4DQ8Y@85009|Propionibacteriales 201174|Actinobacteria S Carbon monoxide dehydrogenase subunit G (CoxG) - - - ko:K09386 - - - - ko00000 - - - COXG k59_1422899_2 716544.wcw_0338 1.58e-18 85.1 COG0167@1|root,COG0167@2|Bacteria,2JGST@204428|Chlamydiae 204428|Chlamydiae F Catalyzes the conversion of dihydroorotate to orotate pyrD - - - - - - - - - - - DHO_dh k59_1056590_1 926550.CLDAP_11080 5.33e-10 63.2 COG1173@1|root,COG1173@2|Bacteria,2G5PJ@200795|Chloroflexi 200795|Chloroflexi EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_1056590_2 1122182.KB903834_gene5990 0.000274 43.9 COG0601@1|root,COG0601@2|Bacteria,2GK0Z@201174|Actinobacteria,4DA2H@85008|Micromonosporales 201174|Actinobacteria EP ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_951351_1 1461694.ATO9_14085 1.75e-132 392.0 COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,2VFZH@28211|Alphaproteobacteria,2PDSN@252301|Oceanicola 28211|Alphaproteobacteria P Catalyzes the synthesis of activated sulfate cysC - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,ATP-sulfurylase,HTH_24,PUA_2 k59_1160115_1 1000565.METUNv1_03680 1.99e-52 185.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2VIKD@28216|Betaproteobacteria,2KUEW@206389|Rhodocyclales 206389|Rhodocyclales K Fis family transcriptional regulator poxR - - - - - - - - - - - HTH_8,Sigma54_activat,V4R,XylR_N k59_115443_1 1249627.D779_2091 1.25e-86 269.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,1WXS3@135613|Chromatiales 135613|Chromatiales S Flavocytochrome c sulphide dehydrogenase, flavin-binding - GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.8.2.3 ko:K17229 ko00920,ko01120,map00920,map01120 - R09499 - ko00000,ko00001,ko01000 - - - FCSD-flav_bind,Pyr_redox_2,TAT_signal k59_1370552_1 1283283.ATXA01000025_gene3655 2e-30 120.0 COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria 201174|Actinobacteria S Pfam Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1370552_2 557599.MKAN_19840 2.51e-27 112.0 COG2124@1|root,COG2124@2|Bacteria,2GNZS@201174|Actinobacteria,2361J@1762|Mycobacteriaceae 201174|Actinobacteria Q cytochrome P-450 - - - - - - - - - - - - p450 k59_378439_2 436308.Nmar_0230 4.98e-31 111.0 COG0526@1|root,arCOG01972@2157|Archaea,41T6S@651137|Thaumarchaeota 651137|Thaumarchaeota O Thioredoxin - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_1004507_1 1071085.KK033114_gene1321 1.57e-20 90.1 COG0517@1|root,arCOG00606@2157|Archaea,2Y03P@28890|Euryarchaeota,23XB9@183963|Halobacteria 183963|Halobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_848175_1 983920.Y88_0733 2.35e-30 120.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,2K1MX@204457|Sphingomonadales 204457|Sphingomonadales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_848175_2 314287.GB2207_11713 3.37e-33 123.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1J4NR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - Peptidase_M23 k59_642732_1 243231.GSU2524 2e-15 78.6 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKFA@28221|Deltaproteobacteria 28221|Deltaproteobacteria T response regulator - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_483777_1 1122604.JONR01000001_gene1704 6.2e-40 149.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1RMHR@1236|Gammaproteobacteria,1X5VF@135614|Xanthomonadales 135614|Xanthomonadales Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_483777_2 331869.BAL199_18238 1.47e-76 235.0 COG4977@1|root,COG4977@2|Bacteria,1QUTN@1224|Proteobacteria,2TW75@28211|Alphaproteobacteria 28211|Alphaproteobacteria K DJ-1/PfpI family - - - - - - - - - - - - DJ-1_PfpI k59_534635_1 395493.BegalDRAFT_2459 6.76e-75 247.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,45ZPW@72273|Thiotrichales 72273|Thiotrichales P heavy metal translocating P-type ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_68097_1 1238182.C882_4375 5.23e-64 211.0 COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2TQZC@28211|Alphaproteobacteria,2JQDS@204441|Rhodospirillales 204441|Rhodospirillales E Periplasmic binding protein - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_386037_2 1177181.T9A_02933 1.34e-55 177.0 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,1S3P6@1236|Gammaproteobacteria,1XJJ2@135619|Oceanospirillales 135619|Oceanospirillales J Binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_386037_3 391625.PPSIR1_23839 4.95e-15 69.3 COG1841@1|root,COG1841@2|Bacteria,1Q1P2@1224|Proteobacteria,437D4@68525|delta/epsilon subdivisions,2X2J6@28221|Deltaproteobacteria,2YW77@29|Myxococcales 28221|Deltaproteobacteria J Ribosomal protein L30 rpmD - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_650204_1 189753.AXAS01000002_gene5404 5.54e-46 154.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2TT6A@28211|Alphaproteobacteria,3JRQB@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_650204_2 443144.GM21_3308 7.94e-36 133.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria 28221|Deltaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_279729_1 796620.VIBC2010_11571 1.97e-11 64.3 COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,1S3PA@1236|Gammaproteobacteria,1XXD8@135623|Vibrionales 135623|Vibrionales U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE k59_279729_2 1182590.BN5_03653 3.42e-97 285.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria,1YD59@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K Participates in transcription elongation, termination and antitermination nusG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_1376013_1 330214.NIDE0827 2.38e-63 206.0 COG0674@1|root,COG0674@2|Bacteria,3J105@40117|Nitrospirae 40117|Nitrospirae C Pyruvate:ferredoxin oxidoreductase core domain II - - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_807324_1 243265.plu4880 6.06e-93 283.0 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,1RRCR@1236|Gammaproteobacteria 1236|Gammaproteobacteria K adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins - GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018117,GO:0018175,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046983,GO:0070566,GO:0070733,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564 - - - - - - - - - - Fic,Fic_N k59_592616_1 1348635.BBJY01000016_gene4068 4.79e-10 66.2 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria,1XSR4@135623|Vibrionales 135623|Vibrionales M COG0859 ADP-heptose LPS heptosyltransferase - - - ko:K12982 - - - - ko00000,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_854004_1 1121033.AUCF01000006_gene4125 4.63e-26 110.0 COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2TTK9@28211|Alphaproteobacteria,2JPFV@204441|Rhodospirillales 204441|Rhodospirillales O Uncharacterized protein family (UPF0051) sufD - - ko:K09015 - - - - ko00000 - - - UPF0051 k59_854004_2 865938.Weevi_0349 1.04e-12 66.2 COG0396@1|root,COG0396@2|Bacteria,4NEMY@976|Bacteroidetes,1HWTU@117743|Flavobacteriia 976|Bacteroidetes O Part of SUF system involved in inserting iron-sulfur clusters into proteins sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_123766_2 1229909.NSED_08780 5.51e-59 191.0 COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_699080_1 1521187.JPIM01000114_gene1930 1.82e-104 310.0 COG0451@1|root,COG0451@2|Bacteria,2G64F@200795|Chloroflexi,374WM@32061|Chloroflexia 32061|Chloroflexia M PFAM NAD-dependent epimerase dehydratase - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_75587_1 1026882.MAMP_03126 5.5e-41 142.0 COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,1RY2B@1236|Gammaproteobacteria,4619J@72273|Thiotrichales 72273|Thiotrichales S BON domain - - - - - - - - - - - - BON k59_75587_2 232346.JHQL01000003_gene297 2.69e-23 94.4 COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,1RS1Y@1236|Gammaproteobacteria,1XI6S@135619|Oceanospirillales 135619|Oceanospirillales G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271,ko:K12961 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005,ko03036 - - - SIS_2 k59_957684_1 1123368.AUIS01000005_gene483 1.13e-146 426.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,2NBWP@225057|Acidithiobacillales 225057|Acidithiobacillales C 4Fe-4S dicluster domain glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7 k59_1165215_1 243233.MCA2283 1.82e-43 157.0 COG0439@1|root,COG0439@2|Bacteria,1NHC0@1224|Proteobacteria 1224|Proteobacteria I Biotin carboxylase - - - - - - - - - - - - - k59_1431291_2 655815.ZPR_0137 5.99e-43 154.0 COG0422@1|root,COG0422@2|Bacteria,4NFTF@976|Bacteroidetes,1HZ6B@117743|Flavobacteriia 976|Bacteroidetes H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_854018_1 187272.Mlg_1343 1.84e-85 267.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1WWWR@135613|Chromatiales 135613|Chromatiales M Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1321621_1 1038859.AXAU01000003_gene6194 1.36e-57 204.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,3JVS5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_1484943_1 1121374.KB891587_gene3038 3.16e-24 106.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria 1236|Gammaproteobacteria KL helicase dinG - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,ResIII k59_854020_2 211165.AJLN01000040_gene6499 0.000899 41.6 COG0517@1|root,COG0517@2|Bacteria,1GKSH@1117|Cyanobacteria,1JMNG@1189|Stigonemataceae 1117|Cyanobacteria S CP12 - - - - - - - - - - - - CP12 k59_957694_4 444862.E3SM46_9CAUD 3.77e-38 132.0 4QD87@10239|Viruses,4QWT7@35237|dsDNA viruses no RNA stage,4QQ2M@28883|Caudovirales,4QK7F@10662|Myoviridae 10662|Myoviridae S Domain of unknown function (DUF4385) - - - - - - - - - - - - - k59_1063398_1 395493.BegalDRAFT_0484 7.92e-107 330.0 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,45ZSF@72273|Thiotrichales 72273|Thiotrichales E arginine decarboxylase speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_386092_1 1121413.JMKT01000014_gene2463 4.77e-08 62.4 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2WJ30@28221|Deltaproteobacteria,2M8BK@213115|Desulfovibrionales 28221|Deltaproteobacteria L Belongs to the helicase family. UvrD subfamily - - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_906462_1 511062.GU3_10400 3.02e-36 141.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1Y3TA@135624|Aeromonadales 135624|Aeromonadales M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - DUF3340,PDZ,Peptidase_S41 k59_227017_1 861299.J421_2386 1.76e-29 122.0 COG1629@1|root,COG4771@2|Bacteria,1ZU8C@142182|Gemmatimonadetes 2|Bacteria P Carboxypeptidase regulatory-like domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarboxypepD_reg,Plug,TonB_dep_Rec k59_1376053_1 983545.Glaag_3546 1.75e-43 157.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,465F9@72275|Alteromonadaceae 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_491356_2 38833.XP_003055580.1 2.05e-05 48.9 COG0465@1|root,KOG0731@2759|Eukaryota,37NIU@33090|Viridiplantae,34J3Q@3041|Chlorophyta 3041|Chlorophyta O Peptidase family M41 - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,Peptidase_M41 k59_1063400_1 1121382.JQKG01000053_gene2149 2.46e-07 50.8 COG1247@1|root,COG1247@2|Bacteria,1WK8X@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M Acetyltransferase (GNAT) domain - - 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 - R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 - - - Acetyltransf_4 k59_1063400_2 502025.Hoch_5991 4.51e-111 330.0 COG0500@1|root,COG2226@2|Bacteria,1QY1T@1224|Proteobacteria,42YBC@68525|delta/epsilon subdivisions,2WUEA@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q methyltransferase - - - - - - - - - - - - - k59_1063400_4 7739.XP_002590720.1 7.76e-34 119.0 2CZEB@1|root,2S9YW@2759|Eukaryota,3AB3P@33154|Opisthokonta,3BUXI@33208|Metazoa,3DB54@33213|Bilateria 33208|Metazoa S Cupin domain - - - - - - - - - - - - Cupin_2 k59_123808_1 261292.Nit79A3_2341 5.21e-13 73.6 COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,372V5@32003|Nitrosomonadales 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - EAL,GGDEF,HAMP,LapD_MoxY_N,PAS,PAS_3,PAS_4,PAS_9 k59_1277239_1 879212.DespoDRAFT_01456 1.1e-08 53.5 COG0614@1|root,COG0614@2|Bacteria,1N7EM@1224|Proteobacteria,42VJU@68525|delta/epsilon subdivisions,2WRA4@28221|Deltaproteobacteria,2MM3T@213118|Desulfobacterales 28221|Deltaproteobacteria P PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_3 k59_854967_1 1056512.D515_04339 3.35e-17 80.5 COG2010@1|root,COG2010@2|Bacteria,1N9MS@1224|Proteobacteria,1T0TG@1236|Gammaproteobacteria,1XZ84@135623|Vibrionales 135623|Vibrionales C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_907337_2 322710.Avin_17500 1.47e-184 526.0 COG1524@1|root,COG1524@2|Bacteria,1N5SF@1224|Proteobacteria 1224|Proteobacteria S type I phosphodiesterase nucleotide pyrophosphatase phnA - 3.11.1.2 ko:K19670 ko00440,map00440 - R00318 RC01309 ko00000,ko00001,ko01000 - - - Phosphodiest k59_907337_3 935261.JAGL01000072_gene247 2.88e-107 318.0 COG3639@1|root,COG3639@2|Bacteria,1NR84@1224|Proteobacteria,2UNP1@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 k59_1223753_1 583345.Mmol_0711 8.3e-95 296.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2VHJ8@28216|Betaproteobacteria,2KKG7@206350|Nitrosomonadales 206350|Nitrosomonadales J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - tRNA_U5-meth_tr k59_1432407_2 1123279.ATUS01000001_gene2594 4.52e-56 188.0 COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,1RN53@1236|Gammaproteobacteria,1J4US@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.68 ko:K00154 - - - - ko00000,ko01000 - - - Aldedh k59_387254_1 67352.JODS01000001_gene463 6.76e-12 62.0 COG2104@1|root,COG2104@2|Bacteria,2GQKM@201174|Actinobacteria 201174|Actinobacteria H ThiS family thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_387254_2 398767.Glov_0036 6.92e-107 316.0 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,42MNC@68525|delta/epsilon subdivisions,2WIUI@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG k59_1486075_1 1172188.KB911822_gene1015 1.5e-15 80.9 COG1541@1|root,COG1541@2|Bacteria,2GJC7@201174|Actinobacteria,4FG54@85021|Intrasporangiaceae 201174|Actinobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) paaK - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_1223760_1 717774.Marme_1999 1.61e-83 273.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1XHTN@135619|Oceanospirillales 135619|Oceanospirillales J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1322227_1 1517682.HW49_03575 0.000454 44.7 COG0247@1|root,COG1139@1|root,COG0247@2|Bacteria,COG1139@2|Bacteria,4NEBT@976|Bacteroidetes,2FP2X@200643|Bacteroidia,22W4D@171551|Porphyromonadaceae 976|Bacteroidetes C 4Fe-4S ferredoxin - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_1322227_2 713586.KB900536_gene2018 6.47e-74 229.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RMVZ@1236|Gammaproteobacteria,1WYGZ@135613|Chromatiales 135613|Chromatiales C Cysteine-rich domain - - - ko:K18928 - - - - ko00000 - - - CCG k59_750083_1 1382303.JPOM01000001_gene2150 1.66e-16 77.4 COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2TV3A@28211|Alphaproteobacteria,2KG6B@204458|Caulobacterales 204458|Caulobacterales K Transcriptional regulator - - - ko:K07667 ko02020,ko02024,map02020,map02024 M00454 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_387266_1 797299.HALLA_15195 2.19e-44 156.0 COG2141@1|root,arCOG02410@2157|Archaea,2XU72@28890|Euryarchaeota,23S3D@183963|Halobacteria 183963|Halobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_907353_2 247156.NFA_51370 2.02e-09 61.6 COG2050@1|root,COG2050@2|Bacteria,2HHJ1@201174|Actinobacteria,4FUYX@85025|Nocardiaceae 201174|Actinobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_593541_1 1502852.FG94_04989 4.72e-36 138.0 COG1783@1|root,COG1783@2|Bacteria,1R66A@1224|Proteobacteria,2W8DW@28216|Betaproteobacteria,477HA@75682|Oxalobacteraceae 28216|Betaproteobacteria S Terminase RNAseH like domain - - - - - - - - - - - - Terminase_3,Terminase_3C k59_958519_1 445685.E3SKR7_9CAUD 1.83e-22 90.1 4QBRV@10239|Viruses,4QVGW@35237|dsDNA viruses no RNA stage,4QQIY@28883|Caudovirales,4QHYU@10662|Myoviridae 10662|Myoviridae S Pfam:Trans_coact - - - - - - - - - - - - - k59_333099_1 768671.ThimaDRAFT_3491 4.39e-58 191.0 COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1WWNR@135613|Chromatiales 135613|Chromatiales M Belongs to the NAD(P)-dependent epimerase dehydratase family - - 5.1.3.2,5.1.3.5 ko:K01784,ko:K12448 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R01473,R02984 RC00289,RC00528 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_387276_1 666685.R2APBS1_2635 2.33e-59 204.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1X3CX@135614|Xanthomonadales 135614|Xanthomonadales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_333103_1 1166018.FAES_0951 9.84e-56 188.0 COG0439@1|root,COG0439@2|Bacteria,4NFEQ@976|Bacteroidetes,47MHE@768503|Cytophagia 976|Bacteroidetes I TIGRFAM acetyl-CoA carboxylase, biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_854999_1 999541.bgla_1g27930 2.16e-26 99.4 COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2VSKY@28216|Betaproteobacteria,1K7RI@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the HesB IscA family iscA - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_854999_2 713586.KB900536_gene441 6.1e-70 214.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1WYAE@135613|Chromatiales 135613|Chromatiales F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_593554_1 266835.14025889 6.85e-85 259.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,43KFS@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_2 k59_124931_1 1492922.GY26_06735 2.11e-29 119.0 COG1018@1|root,COG1018@2|Bacteria,1MY2Q@1224|Proteobacteria,1RQZ8@1236|Gammaproteobacteria,1J59I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase FAD-binding domain paaE GO:0000166,GO:0003674,GO:0005488,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0036094,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051536,GO:0051537,GO:0051540,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0097159,GO:0098754,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 1.14.13.142 ko:K02613,ko:K15983 ko00360,ko00984,ko01100,ko01120,map00360,map00984,map01100,map01120 - R09838,R09860 RC02690,RC02691 ko00000,ko00001,ko01000 - - iEcHS_1320.EcHS_A1479 FAD_binding_6,Fer2,NAD_binding_1 k59_1011238_1 391615.ABSJ01000037_gene945 4.88e-63 212.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1J55U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Multicopper oxidase pcoA - - - - - - - - - - - CopB,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_750107_2 246197.MXAN_5788 6.61e-10 60.1 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2YTYC@29|Myxococcales 28221|Deltaproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N,cNMP_binding k59_958535_2 1142394.PSMK_05860 1.65e-16 82.8 COG1043@1|root,COG1043@2|Bacteria,2IYJJ@203682|Planctomycetes 203682|Planctomycetes M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_124935_1 436308.Nmar_0649 2.67e-118 346.0 COG1260@1|root,arCOG04213@2157|Archaea,41SEZ@651137|Thaumarchaeota 651137|Thaumarchaeota I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth k59_492514_1 1121106.JQKB01000064_gene5372 1.8e-83 276.0 COG3280@1|root,COG3280@2|Bacteria,1QTVK@1224|Proteobacteria,2TW4J@28211|Alphaproteobacteria 28211|Alphaproteobacteria G synthase treY - 5.4.99.15 ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R09995 - ko00000,ko00001,ko00002,ko01000 - GH13 - Alpha-amylase k59_387296_1 744985.HIMB59_00011980 1.56e-19 88.6 COG2040@1|root,COG2040@2|Bacteria,1QU2A@1224|Proteobacteria,2TS3P@28211|Alphaproteobacteria 28211|Alphaproteobacteria E homocysteine S-methyltransferase - - 2.1.1.10 ko:K00547 ko00270,ko01100,ko01110,map00270,map01100,map01110 - R00650 RC00003,RC00035 ko00000,ko00001,ko01000 - - - S-methyl_trans k59_437801_1 573370.DMR_31250 1.1e-99 308.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJZ3@28221|Deltaproteobacteria,2M9Q6@213115|Desulfovibrionales 28221|Deltaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_1223802_2 1229909.NSED_08760 2.16e-53 170.0 COG0784@1|root,arCOG02391@2157|Archaea 2157|Archaea T response regulator, receiver - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_750110_1 330214.NIDE2654 1.15e-67 233.0 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,3J0WW@40117|Nitrospirae 40117|Nitrospirae T Two component signalling adaptor domain - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,HATPase_c,Hpt,Response_reg k59_492520_1 436308.Nmar_0960 9.09e-97 284.0 COG1056@1|root,arCOG00972@2157|Archaea,41T2U@651137|Thaumarchaeota 651137|Thaumarchaeota H Cytidylyltransferase-like - - 2.7.7.1 ko:K00952 ko00760,ko01100,map00760,map01100 - R00137,R03005 RC00002 ko00000,ko00001,ko01000 - - - CTP_transf_like k59_437809_1 861299.J421_3630 5.86e-86 284.0 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1ZSRY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C 4Fe-4S dicluster domain - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_1116204_1 644801.Psest_0483 1.8e-87 276.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1YZYX@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360 - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_958548_1 502025.Hoch_2607 9.96e-18 85.1 COG3031@1|root,COG3031@2|Bacteria,1NB50@1224|Proteobacteria,42WPG@68525|delta/epsilon subdivisions,2WREX@28221|Deltaproteobacteria,2YVJ9@29|Myxococcales 28221|Deltaproteobacteria U General secretion pathway protein C gspC - - ko:K02452 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - PDZ_2,T2SSC k59_1230823_1 644968.DFW101_1575 4.57e-07 51.2 COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,42MQX@68525|delta/epsilon subdivisions,2WKUP@28221|Deltaproteobacteria,2MA0I@213115|Desulfovibrionales 28221|Deltaproteobacteria E pfam php - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP k59_1230823_2 472759.Nhal_1068 5.37e-40 137.0 COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,1SAW8@1236|Gammaproteobacteria,1X1FX@135613|Chromatiales 135613|Chromatiales T Prokaryotic dksA/traR C4-type zinc finger - - - - - - - - - - - - zf-dskA_traR k59_500545_1 1287116.X734_00245 1.41e-12 75.5 COG0293@1|root,COG0438@1|root,COG1216@1|root,COG0293@2|Bacteria,COG0438@2|Bacteria,COG1216@2|Bacteria,1MU9C@1224|Proteobacteria,2TQJM@28211|Alphaproteobacteria,43HA8@69277|Phyllobacteriaceae 28211|Alphaproteobacteria M Glycosyl transferases group 1 lpcC - - ko:K12989 - - - - ko00000,ko01000,ko01003,ko01005 - GT4 - Glycos_transf_1 k59_444399_1 118161.KB235922_gene3453 4.03e-09 57.8 COG1052@1|root,COG1052@2|Bacteria,1G1BP@1117|Cyanobacteria,3VHQK@52604|Pleurocapsales 1117|Cyanobacteria CH PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - 1.1.1.26,1.20.1.1 ko:K00015,ko:K18916 ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120 - R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_444399_3 324602.Caur_3304 6.76e-53 176.0 COG0388@1|root,COG0388@2|Bacteria,2G6KM@200795|Chloroflexi,375XY@32061|Chloroflexia 32061|Chloroflexia S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_286568_1 999611.KI421505_gene4154 2.56e-53 184.0 COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2TRPW@28211|Alphaproteobacteria,281YC@191028|Leisingera 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_659424_1 1122247.C731_4964 5.56e-85 273.0 COG4584@1|root,COG4584@2|Bacteria,2GM4J@201174|Actinobacteria,235RP@1762|Mycobacteriaceae 201174|Actinobacteria L Integrase core domain - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - rve k59_1647173_1 1191523.MROS_0794 1.76e-84 265.0 COG0644@1|root,COG0644@2|Bacteria 2|Bacteria C geranylgeranyl reductase activity - - 1.14.19.49,1.3.1.101,1.3.7.11,5.5.1.18 ko:K06444,ko:K14257,ko:K17830 ko00253,ko00404,ko00564,ko00906,ko01057,ko01100,ko01110,ko01130,map00253,map00404,map00564,map00906,map01057,map01100,map01110,map01130 M00790,M00823 R05456,R06960,R06963,R07840,R10325,R10326,R10331,R11106,R11478 RC00949,RC01612,RC03134 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3,Lycopene_cycl,NAD_binding_8,Pyr_redox_2,Trp_halogenase k59_860929_1 402626.Rpic_1245 3.27e-31 122.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,1K1ZE@119060|Burkholderiaceae 28216|Betaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_860929_2 204773.HEAR1759 4.21e-14 71.6 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2VIXM@28216|Betaproteobacteria,473IG@75682|Oxalobacteraceae 28216|Betaproteobacteria M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_444418_2 1026882.MAMP_00019 6.94e-77 236.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,460DQ@72273|Thiotrichales 72273|Thiotrichales U MotA TolQ ExbB proton channel - - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_500571_2 1380347.JNII01000007_gene716 2.27e-36 132.0 COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4ESRZ@85013|Frankiales 201174|Actinobacteria L Methyltransferase rsmD - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_860934_1 395494.Galf_2074 0.000403 48.1 COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,2VNY1@28216|Betaproteobacteria,44V9Q@713636|Nitrosomonadales 28216|Betaproteobacteria T PFAM ATP-binding region ATPase domain protein regB - 2.7.13.3 ko:K15011 ko02020,map02020 M00523 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_502066_1 471852.Tcur_4620 7.1e-06 47.4 COG2057@1|root,COG2057@2|Bacteria,2GMA1@201174|Actinobacteria,4EIFA@85012|Streptosporangiales 201174|Actinobacteria I Coenzyme A transferase - - 2.8.3.12 ko:K01040 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_502066_2 58123.JOFJ01000013_gene4896 1.42e-53 177.0 COG1788@1|root,COG1788@2|Bacteria,2GK61@201174|Actinobacteria,4EG8S@85012|Streptosporangiales 201174|Actinobacteria I Coenzyme A transferase cotA - 2.8.3.12 ko:K01039 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_861993_1 765914.ThisiDRAFT_1455 1.01e-138 407.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WW4B@135613|Chromatiales 135613|Chromatiales T response regulator glnG - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_393236_1 1380355.JNIJ01000019_gene4662 3.38e-120 359.0 COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,2UNXP@28211|Alphaproteobacteria,3JSCB@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MA20_01265 - 4.2.1.6 ko:K01684 ko00052,ko01100,ko01120,map00052,map01100,map01120 M00552 R03033 RC00543 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_393236_2 626887.J057_06111 7.05e-54 180.0 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,1RNGM@1236|Gammaproteobacteria,463ZP@72275|Alteromonadaceae 1236|Gammaproteobacteria S N-terminal domain of oxidoreductase - - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N k59_756980_1 1192034.CAP_1842 2.39e-113 341.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2WIQN@28221|Deltaproteobacteria,2YYQJ@29|Myxococcales 28221|Deltaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_965449_2 1035193.HMPREF9073_02105 1.75e-51 172.0 COG0413@1|root,COG0413@2|Bacteria,4NDX4@976|Bacteroidetes,1HXEE@117743|Flavobacteriia,1EQSI@1016|Capnocytophaga 976|Bacteroidetes H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_86191_1 926550.CLDAP_19290 1.44e-65 212.0 COG0624@1|root,COG0624@2|Bacteria,2G8AH@200795|Chloroflexi 200795|Chloroflexi E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_178438_1 246200.SPO1465 8.63e-30 119.0 COG1638@1|root,COG1638@2|Bacteria,1NTFS@1224|Proteobacteria,2U1QM@28211|Alphaproteobacteria 28211|Alphaproteobacteria G transport system periplasmic component - - - - - - - - - - - - DctP k59_1327818_1 207954.MED92_12931 9.28e-65 217.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XR37@135619|Oceanospirillales 135619|Oceanospirillales T COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,Response_reg k59_287756_1 330214.NIDE1358 1e-105 324.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,3J0EB@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_1533318_1 1300350.DSW25_16755 1.15e-53 184.0 COG4782@1|root,COG4782@2|Bacteria,1PSSC@1224|Proteobacteria,2UR7R@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Alpha/beta hydrolase of unknown function (DUF900) - - - - - - - - - - - - DUF900 k59_393265_1 868864.Dester_0096 4.86e-81 257.0 COG0146@1|root,COG0146@2|Bacteria,2G3NG@200783|Aquificae 200783|Aquificae EQ Hydantoinase B/oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_914586_1 1255043.TVNIR_0363 3.16e-53 175.0 COG1586@1|root,COG1586@2|Bacteria,1MXPT@1224|Proteobacteria,1RQSX@1236|Gammaproteobacteria,1WX2Z@135613|Chromatiales 135613|Chromatiales E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speD - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc k59_818092_1 522306.CAP2UW1_2681 1.27e-24 103.0 COG0711@1|root,COG0712@1|root,COG0711@2|Bacteria,COG0712@2|Bacteria,1R6C0@1224|Proteobacteria,2VNRP@28216|Betaproteobacteria 28216|Betaproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B,DUF2934,OSCP k59_660978_1 671143.DAMO_0989 6.91e-36 135.0 COG1812@1|root,COG1812@2|Bacteria 2|Bacteria E S-adenosylmethionine synthetase (AdoMet synthetase) metK-2 - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_Synthase k59_547616_1 768671.ThimaDRAFT_2431 2.55e-62 204.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,1WXHA@135613|Chromatiales 135613|Chromatiales S Peptidogalycan biosysnthesis/recognition - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_818099_1 1122212.AULO01000009_gene857 5.53e-27 114.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1XI0M@135619|Oceanospirillales 135619|Oceanospirillales L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_965491_1 237368.SCABRO_01738 3.62e-59 188.0 COG1830@1|root,COG1830@2|Bacteria,2J2PV@203682|Planctomycetes 203682|Planctomycetes G DeoC/LacD family aldolase - - - - - - - - - - - - DeoC k59_965491_2 102129.Lepto7375DRAFT_3089 0.000673 43.5 COG0156@1|root,COG0156@2|Bacteria,1FZY9@1117|Cyanobacteria,1H9AQ@1150|Oscillatoriales 1117|Cyanobacteria H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - iJN678.bioF Aminotran_1_2 k59_1327849_1 247633.GP2143_16566 1.78e-21 93.2 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1J4GR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J SAM-dependent methyltransferases rlmI - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_1327849_2 323261.Noc_0233 3.71e-91 274.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1WW3W@135613|Chromatiales 135613|Chromatiales M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_234691_1 1121272.KB903292_gene3930 5.43e-80 250.0 COG3752@1|root,COG3752@2|Bacteria,2GNX1@201174|Actinobacteria,4DHYY@85008|Micromonosporales 201174|Actinobacteria S Protein of unknown function (DUF1295) - - - - - - - - - - - - DUF1295 k59_287781_1 865937.Gilli_2309 3.55e-11 63.2 COG2128@1|root,COG2128@2|Bacteria,4NN22@976|Bacteroidetes,1ID3V@117743|Flavobacteriia,2P7C1@244698|Gillisia 976|Bacteroidetes S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD k59_1018261_2 545264.KB898745_gene1048 1.55e-26 111.0 COG0501@1|root,COG0501@2|Bacteria,1MVU4@1224|Proteobacteria,1RPJ5@1236|Gammaproteobacteria,1WWWM@135613|Chromatiales 135613|Chromatiales O PFAM peptidase M48 Ste24p - - - - - - - - - - - - Peptidase_M48 k59_393319_2 330214.NIDE2825 2.82e-31 122.0 COG2804@1|root,COG2804@2|Bacteria,3J0XR@40117|Nitrospirae 2|Bacteria NU Type II/IV secretion system protein gspE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_965507_2 330214.NIDE0968 1.17e-28 105.0 COG1144@1|root,COG1144@2|Bacteria,3J1DG@40117|Nitrospirae 40117|Nitrospirae C Oxidoreductase - - - - - - - - - - - - - k59_1018263_1 1123229.AUBC01000005_gene744 2.97e-51 183.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2TR6F@28211|Alphaproteobacteria,3JR8U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_965510_2 330214.NIDE3825 1.31e-20 87.0 COG3417@1|root,COG3417@2|Bacteria 2|Bacteria M Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) - - - ko:K07337 - - - - ko00000 - - - LpoB k59_445854_2 311403.Arad_3549 2.56e-95 287.0 COG0510@1|root,COG0510@2|Bacteria,1MVBB@1224|Proteobacteria,2TT5Z@28211|Alphaproteobacteria,4B88Z@82115|Rhizobiaceae 28211|Alphaproteobacteria M Choline kinase - - - - - - - - - - - - Choline_kinase k59_661024_1 1236542.BALM01000018_gene1536 1.84e-29 122.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,2Q9II@267890|Shewanellaceae 1236|Gammaproteobacteria S PFAM Patatin rssA GO:0003674,GO:0003824,GO:0016787 - ko:K07001 - - - - ko00000 - - - Patatin k59_1288090_1 1120956.JHZK01000001_gene3449 5.75e-95 299.0 29ISC@1|root,2Z7VE@2|Bacteria,1MWUK@1224|Proteobacteria,2TTFU@28211|Alphaproteobacteria,1JPZS@119043|Rhodobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - DUF3604 k59_1592844_2 472759.Nhal_0594 5.87e-75 231.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,1WWE2@135613|Chromatiales 135613|Chromatiales G Inositol monophosphatase - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_706800_1 1120792.JAFV01000001_gene1983 1.11e-18 90.1 COG0589@1|root,COG0589@2|Bacteria,1MWHD@1224|Proteobacteria,2U0GR@28211|Alphaproteobacteria,370KZ@31993|Methylocystaceae 28211|Alphaproteobacteria T PFAM UspA domain protein - - - - - - - - - - - - Usp k59_340091_1 314345.SPV1_10666 5.15e-29 107.0 28UDP@1|root,2ZGIS@2|Bacteria,1QYVB@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_340091_2 1283300.ATXB01000001_gene43 1.54e-27 112.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XEHC@135618|Methylococcales 135618|Methylococcales P haloacid dehalogenase-like hydrolase - - - - - - - - - - - - E1-E2_ATPase,Hydrolase k59_547674_1 262316.MAP_0238c 2.13e-11 66.6 COG2175@1|root,COG2175@2|Bacteria,2GNUC@201174|Actinobacteria,235P9@1762|Mycobacteriaceae 201174|Actinobacteria Q taurine catabolism dioxygenase - - 1.14.11.17 ko:K03119,ko:K06912 ko00361,ko00430,ko00920,ko01120,ko01220,map00361,map00430,map00920,map01120,map01220 - R05320,R05419,R05493 RC01331,RC01371,RC01372 ko00000,ko00001,ko01000 - - - TauD k59_757032_2 215803.DB30_7822 3.83e-67 221.0 COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,42PTC@68525|delta/epsilon subdivisions,2WM3S@28221|Deltaproteobacteria,2YTUU@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF1015) - - - - - - - - - - - - DUF1015 k59_393349_1 933262.AXAM01000083_gene762 1.19e-79 248.0 COG0426@1|root,COG0426@2|Bacteria,1R4UD@1224|Proteobacteria,43AF5@68525|delta/epsilon subdivisions,2X5UW@28221|Deltaproteobacteria,2MPG5@213118|Desulfobacterales 28221|Deltaproteobacteria C Flavodoxin roo - - - - - - - - - - - Flavodoxin_1,Lactamase_B,Lactamase_B_2 k59_1648856_1 445970.ALIPUT_02705 2.39e-46 169.0 COG0486@1|root,COG0486@2|Bacteria,4NECT@976|Bacteroidetes,2FMER@200643|Bacteroidia,22URH@171550|Rikenellaceae 976|Bacteroidetes S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_1441833_1 519989.ECTPHS_09323 1.5e-45 160.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1WX3A@135613|Chromatiales 135613|Chromatiales D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_12259_1 396588.Tgr7_3044 9.33e-80 244.0 COG0515@1|root,COG0515@2|Bacteria,1NUIB@1224|Proteobacteria 1224|Proteobacteria KLT Protein tyrosine kinase - - - - - - - - - - - - Pkinase k59_12259_2 754476.Q7A_3014 1.95e-15 75.5 COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,1RQM4@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid vgb - - ko:K18235 - - - - ko00000,ko01000,ko01504 - - - SGL k59_661057_1 40571.JOEA01000005_gene4262 9.88e-26 109.0 COG1960@1|root,COG1960@2|Bacteria,2GNTA@201174|Actinobacteria,4DZH9@85010|Pseudonocardiales 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1495629_1 1029824.AFID01000008_gene2228 8.2e-17 84.7 COG0028@1|root,COG0028@2|Bacteria,2GKQM@201174|Actinobacteria,1W8I6@1268|Micrococcaceae 201174|Actinobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_512187_2 323261.Noc_0348 5.3e-17 80.1 COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,1S9FW@1236|Gammaproteobacteria,1WXHE@135613|Chromatiales 135613|Chromatiales M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA - - ko:K03634 - - - - ko00000 - - - LolA k59_400774_2 575788.VS_II1488 1.88e-05 48.9 COG2972@1|root,COG2972@2|Bacteria,1RHZQ@1224|Proteobacteria,1T01W@1236|Gammaproteobacteria,1XSCC@135623|Vibrionales 135623|Vibrionales T signal transduction protein with a C-terminal ATPase domain VVA0018 - - - - - - - - - - - HATPase_c,His_kinase k59_829724_1 1123400.KB904746_gene1349 3.97e-06 47.8 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,45ZRF@72273|Thiotrichales 72273|Thiotrichales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_829724_2 396588.Tgr7_0517 1.21e-87 271.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_556042_1 929712.KI912613_gene723 5.83e-66 219.0 COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4CR6V@84995|Rubrobacteria 84995|Rubrobacteria I AMP-binding enzyme - - - - - - - - - - - - AMP-binding k59_1540559_1 436308.Nmar_1648 4.51e-90 281.0 arCOG08793@1|root,arCOG08793@2157|Archaea,41TBC@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1335332_2 502025.Hoch_4422 5.28e-89 265.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,43B5T@68525|delta/epsilon subdivisions,2X6JE@28221|Deltaproteobacteria,2Z3BD@29|Myxococcales 28221|Deltaproteobacteria C Inorganic pyrophosphatase - - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_142713_1 1229909.NSED_02410 9.25e-54 187.0 arCOG11445@1|root,arCOG11445@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_672602_1 1156919.QWC_06739 6.24e-79 259.0 COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,2VIJQ@28216|Betaproteobacteria 28216|Betaproteobacteria E orn lys arg decarboxylase - - 4.1.1.19 ko:K01583 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - OKR_DC_1,OKR_DC_1_C k59_973723_1 189753.AXAS01000055_gene5700 8.13e-203 572.0 COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria,3JT1R@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Pyridine nucleotide-disulphide oxidoreductase - - - ko:K07222 - - - - ko00000 - - - Pyr_redox_3 k59_973723_2 522306.CAP2UW1_2430 4.31e-43 152.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - DUF5128,NHL k59_1540577_1 1348657.M622_02895 4.28e-64 208.0 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2VJBJ@28216|Betaproteobacteria,2KVC5@206389|Rhodocyclales 28216|Betaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_96695_1 1280706.AUJE01000011_gene465 1.08e-05 49.3 COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,4H2N9@909932|Negativicutes 909932|Negativicutes J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_96695_2 330214.NIDE2055 4.13e-28 113.0 COG0815@1|root,COG0815@2|Bacteria,3J0HA@40117|Nitrospirae 40117|Nitrospirae M Carbon-nitrogen hydrolase lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_350175_1 1122194.AUHU01000004_gene1444 4.64e-57 194.0 COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,1RPTG@1236|Gammaproteobacteria,4661E@72275|Alteromonadaceae 1236|Gammaproteobacteria F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis - - 2.4.2.4 ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C k59_96703_1 1229909.NSED_05000 5.94e-14 65.9 arCOG11730@1|root,arCOG11730@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_96703_2 1229909.NSED_05005 3.41e-22 87.4 arCOG10560@1|root,arCOG10560@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_869810_1 404589.Anae109_2793 5.65e-78 258.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2YX1W@29|Myxococcales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K04076 - - - - ko00000,ko01000,ko01002 - - - AAA_32,Lon_C,Mg_chelatase k59_715232_2 62928.azo1572 1.83e-07 52.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2WEDQ@28216|Betaproteobacteria,2KUKA@206389|Rhodocyclales 206389|Rhodocyclales P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components oppB - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_350177_1 1123368.AUIS01000024_gene951 3.89e-95 288.0 COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,1RMR8@1236|Gammaproteobacteria,2NCYJ@225057|Acidithiobacillales 225057|Acidithiobacillales P cation diffusion facilitator family transporter - - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux k59_764712_1 1459636.NTE_02264 3.62e-27 112.0 COG1304@1|root,arCOG00613@2157|Archaea 2157|Archaea C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) fni - 5.3.3.2 ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01123 RC00455 ko00000,ko00001,ko00002,ko01000 - - - FMN_dh k59_764712_2 1178482.BJB45_14630 7.23e-10 59.3 COG1309@1|root,COG1309@2|Bacteria,1N1Q3@1224|Proteobacteria,1S6W5@1236|Gammaproteobacteria,1XK2A@135619|Oceanospirillales 135619|Oceanospirillales K transcriptional regulator - - - - - - - - - - - - TetR_N k59_1179163_1 1121918.ARWE01000001_gene3016 5.72e-67 218.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,42MPG@68525|delta/epsilon subdivisions,2WKW8@28221|Deltaproteobacteria,43UK8@69541|Desulfuromonadales 28221|Deltaproteobacteria HJ RimK-like ATPgrasp N-terminal domain - - - - - - - - - - - - Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK k59_243148_1 1123054.KB907709_gene722 1.31e-59 196.0 COG5505@1|root,COG5505@2|Bacteria,1MW87@1224|Proteobacteria,1RQPZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S integral membrane protein - - - - - - - - - - - - DUF819 k59_513807_2 1105367.CG50_00305 2.64e-06 50.4 COG1063@1|root,COG1063@2|Bacteria,1MW6Y@1224|Proteobacteria,2TSUK@28211|Alphaproteobacteria 28211|Alphaproteobacteria E alcohol dehydrogenase - - - ko:K18369 ko00640,map00640 - R10703 RC00545 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_829794_1 1121352.JHZP01000007_gene1221 1.33e-43 151.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2VHDG@28216|Betaproteobacteria,2KQB9@206351|Neisseriales 206351|Neisseriales M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_1600216_1 234267.Acid_1352 1.8e-23 103.0 COG0745@1|root,COG0834@1|root,COG2202@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0834@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,3Y3F8@57723|Acidobacteria 57723|Acidobacteria T histidine kinase A domain protein domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,Response_reg,SBP_bac_3 k59_764722_1 436229.JOEH01000004_gene55 7.9e-94 291.0 COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria,2NM7I@228398|Streptacidiphilus 201174|Actinobacteria J Aminoacyl-tRNA editing domain proS GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_607804_1 869724.H6BI46_9CAUD 3.38e-56 204.0 4QEE7@10239|Viruses,4QV59@35237|dsDNA viruses no RNA stage,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae 10662|Myoviridae S Pfam:DUF4815 - - - - - - - - - - - - - k59_185742_2 443144.GM21_1632 1.06e-54 182.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU twitching motility protein pilT-4 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_16682_1 1121447.JONL01000001_gene645 1.91e-29 113.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,42M3Y@68525|delta/epsilon subdivisions,2WJH5@28221|Deltaproteobacteria,2M87Y@213115|Desulfovibrionales 28221|Deltaproteobacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_1660522_1 330214.NIDE0690 5.77e-82 263.0 COG4772@1|root,COG4772@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_764728_1 869210.Marky_0266 6.82e-08 53.5 COG1057@1|root,COG1057@2|Bacteria,1WJ70@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_764728_2 754252.PFREUD_08540 9.6e-32 116.0 COG0799@1|root,COG0799@2|Bacteria,2IKZ3@201174|Actinobacteria,4DR96@85009|Propionibacteriales 201174|Actinobacteria S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_243161_2 1380394.JADL01000001_gene2081 1.28e-52 171.0 2BZ0R@1|root,2Z7U0@2|Bacteria,1MX37@1224|Proteobacteria,2U1TX@28211|Alphaproteobacteria,2JW9Y@204441|Rhodospirillales 204441|Rhodospirillales S Nitrile hydratase, alpha chain - - 4.2.1.84 ko:K01721 ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120 - R02828,R04020,R05379,R05596,R07780,R07854 RC00483,RC00792,RC01345,RC01432 ko00000,ko00001,ko01000 - - - NHase_alpha k59_869840_1 948106.AWZT01000027_gene363 3.93e-105 332.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHZQ@28216|Betaproteobacteria,1K4PA@119060|Burkholderiaceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1335389_1 555778.Hneap_0849 1.9e-60 203.0 COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,1T1GV@1236|Gammaproteobacteria 1236|Gammaproteobacteria S (ABC) transporter - - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran k59_400840_1 1123355.JHYO01000036_gene614 1.12e-06 52.4 COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TRQ7@28211|Alphaproteobacteria,370IF@31993|Methylocystaceae 28211|Alphaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_1081728_1 215803.DB30_6769 1.97e-57 200.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,2YUJ6@29|Myxococcales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1660554_1 925775.XVE_1875 5.64e-45 165.0 COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1RNNQ@1236|Gammaproteobacteria,1X4D8@135614|Xanthomonadales 135614|Xanthomonadales S aminopeptidase - - - - - - - - - - - - PA,Peptidase_M28 k59_869854_1 1333998.M2A_0835 1.47e-80 257.0 COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,2TV6G@28211|Alphaproteobacteria,4BRBC@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O Carbamoyltransferase C-terminus - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_1449412_1 234267.Acid_4563 4.15e-52 181.0 COG0477@1|root,COG2814@2|Bacteria,3Y3ZZ@57723|Acidobacteria 57723|Acidobacteria EGP major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_1540627_1 1411123.JQNH01000001_gene398 9.95e-62 202.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TRJV@28211|Alphaproteobacteria 28211|Alphaproteobacteria C belongs to the aldehyde dehydrogenase family ssdA - - - - - - - - - - - Aldedh k59_1540627_2 1205680.CAKO01000005_gene3519 8.51e-190 537.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSX8@28211|Alphaproteobacteria,2JQNE@204441|Rhodospirillales 204441|Rhodospirillales C Iron-containing alcohol dehydrogenase - - - - - - - - - - - - Fe-ADH k59_1507291_1 1247726.MIM_c09560 3.81e-71 226.0 COG1063@1|root,COG1063@2|Bacteria,1MWX0@1224|Proteobacteria,2VKWS@28216|Betaproteobacteria,3T783@506|Alcaligenaceae 28216|Betaproteobacteria E Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1507291_2 998674.ATTE01000001_gene1369 2.12e-53 175.0 COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,1S2WG@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ KR domain - - 1.1.1.69 ko:K00046 - - - - ko00000,ko01000 - - - adh_short_C2 k59_1507293_2 1229909.NSED_07020 2.39e-74 227.0 arCOG08717@1|root,arCOG08717@2157|Archaea,41SFQ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - AhpC-TSA k59_1335411_1 468059.AUHA01000002_gene1094 2.8e-06 54.7 COG1009@1|root,COG1009@2|Bacteria,4NEBM@976|Bacteroidetes,1IQ9D@117747|Sphingobacteriia 976|Bacteroidetes CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_1540631_2 443144.GM21_2330 1.58e-17 82.4 COG0436@1|root,COG0436@2|Bacteria,1QW10@1224|Proteobacteria,42MQA@68525|delta/epsilon subdivisions,2WJDK@28221|Deltaproteobacteria,43S5R@69541|Desulfuromonadales 28221|Deltaproteobacteria E Aminotransferase class I and II bamJ - - - - - - - - - - - Aminotran_1_2 k59_16692_1 667014.Thein_0642 4.1e-37 150.0 2A7N3@1|root,30WK3@2|Bacteria,2GH2V@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria - - - - - - - - - - - - - - - k59_1600255_1 1415755.JQLV01000001_gene1575 3e-07 57.4 COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,1RP39@1236|Gammaproteobacteria,1XIC0@135619|Oceanospirillales 135619|Oceanospirillales EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_607846_1 204669.Acid345_1097 2.97e-115 346.0 COG0459@1|root,COG0459@2|Bacteria,3Y37I@57723|Acidobacteria,2JIV1@204432|Acidobacteriia 204432|Acidobacteriia O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1540636_1 436308.Nmar_1627 1.53e-132 400.0 COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,41SAH@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_400867_1 240016.ABIZ01000001_gene292 2.11e-11 69.7 COG0265@1|root,COG0823@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2234@2|Bacteria,46T85@74201|Verrucomicrobia 74201|Verrucomicrobia OU PA domain - - - - - - - - - - - - PA,PD40,PDZ_2,Peptidase_M28 k59_973820_1 349124.Hhal_1056 4.06e-149 461.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_556152_1 290397.Adeh_1777 3.22e-05 45.8 COG1752@1|root,COG1752@2|Bacteria,1PEH4@1224|Proteobacteria,42XKH@68525|delta/epsilon subdivisions,2WTA6@28221|Deltaproteobacteria,2YWD2@29|Myxococcales 28221|Deltaproteobacteria S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_556152_2 266940.Krad_0179 8.2e-30 127.0 COG2199@1|root,COG2200@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG2203@2|Bacteria,2GJNM@201174|Actinobacteria 201174|Actinobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_8 k59_1600267_1 1117647.M5M_04220 4.11e-05 48.5 COG2165@1|root,COG2165@2|Bacteria,1NF7W@1224|Proteobacteria,1SG03@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K10926 ko05111,map05111 - - - ko00000,ko00001,ko02044 - - - N_methyl k59_1133768_1 589865.DaAHT2_1665 1.29e-60 204.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,42MTY@68525|delta/epsilon subdivisions,2WKII@28221|Deltaproteobacteria,2MI2W@213118|Desulfobacterales 28221|Deltaproteobacteria J TIGRFAM arginyl-tRNA synthetase argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iAF987.Gmet_1434 Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_1600286_1 323848.Nmul_A2700 1.9e-45 165.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VH4J@28216|Betaproteobacteria,372JE@32003|Nitrosomonadales 28216|Betaproteobacteria S ABC transporter C-terminal domain uup - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_455933_1 710421.Mycch_2953 3.65e-24 100.0 COG0183@1|root,COG0183@2|Bacteria,2GKH4@201174|Actinobacteria,2341M@1762|Mycobacteriaceae 201174|Actinobacteria I Acetyl-CoA acetyltransferase - - - - - - - - - - - - - k59_455933_2 1240349.ANGC01000004_gene1811 2.32e-35 135.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FV7A@85025|Nocardiaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_973847_1 243233.MCA1876 8.74e-97 293.0 COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,1RM7T@1236|Gammaproteobacteria,1XE2G@135618|Methylococcales 135618|Methylococcales E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metAS GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0008899,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - HTS k59_1179258_1 886293.Sinac_4484 9.61e-183 536.0 COG0243@1|root,COG0243@2|Bacteria,2IXVV@203682|Planctomycetes 203682|Planctomycetes C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdopterin,Molydop_binding k59_1449470_1 436308.Nmar_0088 5.88e-118 363.0 COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD/H associated - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_672811_1 78245.Xaut_3704 5.59e-86 266.0 COG5323@1|root,COG5323@2|Bacteria,1MW8S@1224|Proteobacteria,2TREI@28211|Alphaproteobacteria,3EYR8@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_672811_2 1082933.MEA186_19997 0.000209 43.9 2E5SR@1|root,330H4@2|Bacteria,1NBT8@1224|Proteobacteria,2UVZC@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1450423_2 644282.Deba_0202 1.72e-36 144.0 COG1463@1|root,COG1463@2|Bacteria,1RFFS@1224|Proteobacteria,42P4P@68525|delta/epsilon subdivisions,2WKQH@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q ABC-type transport system involved in resistance to organic solvents periplasmic component - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_1450423_3 518766.Rmar_0706 2.76e-48 164.0 COG1127@1|root,COG1127@2|Bacteria,4NETG@976|Bacteroidetes,1FIW0@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_17129_1 1122194.AUHU01000003_gene2015 7.49e-83 260.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,464SX@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG0006 Xaa-Pro aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_932904_1 572477.Alvin_1750 0.000797 47.0 COG0642@1|root,COG3437@1|root,COG5000@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria,COG5000@2|Bacteria,1NRP8@1224|Proteobacteria,1T4M1@1236|Gammaproteobacteria,1WYGE@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - - - - - - - - - - HAMP,HATPase_c,HisKA,Response_reg,dCache_1 k59_932904_2 986075.CathTA2_1147 4.92e-51 175.0 COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,4HAY2@91061|Bacilli 91061|Bacilli C Fe-S oxidoreductases - - - ko:K22227 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_1455852_1 1149133.ppKF707_3718 2.35e-22 95.5 COG2010@1|root,COG2010@2|Bacteria,1N5Y7@1224|Proteobacteria,1TBQP@1236|Gammaproteobacteria,1YIJW@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Planctomycete cytochrome C - - - - - - - - - - - - PSCyt1 k59_1455852_2 1395571.TMS3_0118240 3.97e-26 106.0 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,1S9DN@1236|Gammaproteobacteria 1236|Gammaproteobacteria G peptidylprolyl isomerase - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3 k59_19709_1 472759.Nhal_1823 7.11e-45 161.0 COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1S9R4@1236|Gammaproteobacteria,1X24A@135613|Chromatiales 135613|Chromatiales T Universal stress protein family - - - - - - - - - - - - Usp k59_19709_2 861299.J421_3816 6.55e-35 136.0 COG0366@1|root,COG0366@2|Bacteria 2|Bacteria G hydrolase activity, hydrolyzing O-glycosyl compounds glgE - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3416 k59_615475_1 272624.lpg2566 4.71e-38 135.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,1RP6D@1236|Gammaproteobacteria,1JEXA@118969|Legionellales 118969|Legionellales L Integrase core domain - - - - - - - - - - - - HTH_21,rve,rve_3 k59_615475_2 1121937.AUHJ01000004_gene1105 8.15e-31 109.0 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,1S9EI@1236|Gammaproteobacteria,468HZ@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives lcrS - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_408539_1 243090.RB8254 5.01e-43 157.0 COG0531@1|root,COG0589@1|root,COG0531@2|Bacteria,COG0589@2|Bacteria,2J0UK@203682|Planctomycetes 203682|Planctomycetes E Amino acid permease - - - ko:K16238 - - - - ko00000,ko02000 2.A.3.5 - - AA_permease_2 k59_357803_1 439481.Aboo_0341 2.96e-28 110.0 COG1656@1|root,arCOG04290@2157|Archaea,2XXTT@28890|Euryarchaeota,3F3CD@33867|unclassified Euryarchaeota 28890|Euryarchaeota S Mut7-C RNAse domain - - - ko:K09122 - - - - ko00000 - - - Mut7-C k59_1341832_1 477184.KYC_20024 1.13e-87 267.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VPNH@28216|Betaproteobacteria,3T6GX@506|Alcaligenaceae 28216|Betaproteobacteria U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1185582_1 1306406.ASHX01000001_gene3301 2.36e-39 147.0 COG0477@1|root,COG0477@2|Bacteria,2GIYR@201174|Actinobacteria 201174|Actinobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_722677_1 998674.ATTE01000001_gene1260 1.74e-97 291.0 COG1173@1|root,COG1173@2|Bacteria,1MU0P@1224|Proteobacteria,1RVZU@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_1397286_1 330214.NIDE0032 9.98e-53 184.0 COG1131@1|root,COG1131@2|Bacteria 2|Bacteria V ATPase activity - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_408554_1 697282.Mettu_0065 2.21e-39 143.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU twitching motility protein uptC - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_149514_1 1265505.ATUG01000002_gene1748 1.44e-77 253.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,43AZ4@68525|delta/epsilon subdivisions,2X6DG@28221|Deltaproteobacteria,2MPHR@213118|Desulfobacterales 1224|Proteobacteria E FAD dependent oxidoreductase central domain dmgdh2 - 1.5.8.4 ko:K00315 ko00260,ko01100,map00260,map01100 - R01565 RC00181 ko00000,ko00001,ko01000 - - - DAO,FAO_M,GCV_T,GCV_T_C k59_1089308_1 1123371.ATXH01000032_gene457 4.36e-46 154.0 COG0231@1|root,COG0231@2|Bacteria,2GH2U@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_1248735_2 36874.HQ34_01985 4.52e-13 68.9 COG0568@1|root,COG0568@2|Bacteria,4NEBF@976|Bacteroidetes,2FNVQ@200643|Bacteroidia,22XDM@171551|Porphyromonadaceae 976|Bacteroidetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_722709_1 306263.Cla_0138 1.44e-37 140.0 COG0168@1|root,COG0168@2|Bacteria,1N412@1224|Proteobacteria,42MBI@68525|delta/epsilon subdivisions,2YMWN@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Potassium uptake protein ktrB - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_104442_1 2340.JV46_16020 8.35e-52 172.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1J4IA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006780,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046394,GO:0046483,GO:0046501,GO:0046502,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO3734,iSBO_1134.SBO_4018 URO-D k59_357849_1 1219035.NT2_05_04640 1.32e-97 316.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,2K2DM@204457|Sphingomonadales 204457|Sphingomonadales C PFAM pyruvate ferredoxin flavodoxin oxidoreductase - - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_615536_1 272134.KB731324_gene2969 3.62e-35 134.0 COG1173@1|root,COG1173@2|Bacteria,1G0BC@1117|Cyanobacteria,1H8MT@1150|Oscillatoriales 1117|Cyanobacteria EP 'ABC-type dipeptide oligopeptide nickel transport oppC - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_193444_1 63737.Npun_F0961 1.86e-28 118.0 COG0457@1|root,COG0457@2|Bacteria,1G31A@1117|Cyanobacteria,1HKVY@1161|Nostocales 1117|Cyanobacteria S tetratricopeptide - - - - - - - - - - - - - k59_408614_1 745310.G432_10700 5.15e-59 201.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TQMV@28211|Alphaproteobacteria,2K32Q@204457|Sphingomonadales 204457|Sphingomonadales G PQQ-like domain - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 k59_1089347_1 546270.GEMHA0001_1532 8.71e-09 56.6 COG1121@1|root,COG1121@2|Bacteria,1TQJ3@1239|Firmicutes,4HA2W@91061|Bacilli,3WDWS@539002|Bacillales incertae sedis 91061|Bacilli P ATPases associated with a variety of cellular activities sitB - 3.6.3.35 ko:K02074,ko:K09820,ko:K10830,ko:K11706,ko:K19973 ko02010,map02010 M00243,M00244,M00318,M00791,M00792 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15,3.A.1.15.14,3.A.1.15.15,3.A.1.15.2,3.A.1.15.6 - - ABC_tran k59_1089347_2 1121097.JCM15093_1081 7.06e-05 48.1 COG0803@1|root,COG0803@2|Bacteria,4NGMC@976|Bacteroidetes,2FMQR@200643|Bacteroidia,4AMW6@815|Bacteroidaceae 976|Bacteroidetes P COG0803 ABC-type metal ion transport system, periplasmic component surface adhesin mntA - - ko:K09815,ko:K11707 ko02010,map02010 M00242,M00319 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_250621_1 1089546.AQUI01000002_gene2984 2.07e-34 135.0 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,2GMBK@201174|Actinobacteria,408NP@622450|Actinopolysporales 201174|Actinobacteria E 2Fe-2S iron-sulfur cluster binding domain soxA - 1.5.3.1 ko:K00302 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2,SoxD k59_1185649_1 748658.KB907314_gene143 2.74e-60 204.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,1X01D@135613|Chromatiales 135613|Chromatiales O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA - - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_1185657_1 323261.Noc_2482 2.7e-51 167.0 COG0529@1|root,COG0529@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1WY0V@135613|Chromatiales 135613|Chromatiales F Catalyzes the synthesis of activated sulfate cysC - 2.7.1.25 ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase k59_1185657_2 1123354.AUDR01000016_gene1360 1.29e-21 93.6 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2VGZI@28216|Betaproteobacteria,1KREH@119069|Hydrogenophilales 119069|Hydrogenophilales M UDP binding domain - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1033689_1 717605.Theco_3902 1.64e-55 185.0 COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,4HBXF@91061|Bacilli,26SEN@186822|Paenibacillaceae 91061|Bacilli M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_1141759_1 1206744.BAGL01000121_gene3156 2.25e-12 72.0 COG1577@1|root,COG1577@2|Bacteria,2IAQ7@201174|Actinobacteria,4G15I@85025|Nocardiaceae 201174|Actinobacteria I GHMP kinases C terminal mvk - 2.7.1.36 ko:K00869 ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146 M00095 R02245 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_722763_1 749927.AMED_6728 1.48e-63 216.0 COG0243@1|root,COG0243@2|Bacteria,2GJWZ@201174|Actinobacteria,4DXM3@85010|Pseudonocardiales 201174|Actinobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - iNJ661.Rv2900c Molybdopterin,Molydop_binding k59_193506_1 1415780.JPOG01000001_gene304 1.88e-84 260.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1X4F6@135614|Xanthomonadales 135614|Xanthomonadales NU twitching motility protein - - - - - - - - - - - - T2SSE k59_1397392_1 1077285.AGDG01000018_gene397 3.9e-10 67.8 COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,2FNQB@200643|Bacteroidia,4AMAR@815|Bacteroidaceae 976|Bacteroidetes G pectate lyase K01728 - - - - - - - - - - - - Pec_lyase_C k59_1033723_2 314287.GB2207_04887 8.08e-46 149.0 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,1S9DN@1236|Gammaproteobacteria,1J6SG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G COG0760 Parvulin-like peptidyl-prolyl isomerase ppiC - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3 k59_1341964_1 1279017.AQYJ01000026_gene57 7e-107 347.0 COG1360@1|root,COG2885@1|root,COG1360@2|Bacteria,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,1T4AK@1236|Gammaproteobacteria,46ACU@72275|Alteromonadaceae 1236|Gammaproteobacteria M OmpA family - - - - - - - - - - - - DUF11,OmpA k59_1605718_1 1229909.NSED_08480 9.81e-167 478.0 COG1290@1|root,arCOG01721@2157|Archaea,41SDA@651137|Thaumarchaeota 651137|Thaumarchaeota C Cytochrome b subunit of the bc complex - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_463314_1 1437824.BN940_17166 4.87e-12 72.4 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2VI5J@28216|Betaproteobacteria,3T1KI@506|Alcaligenaceae 28216|Betaproteobacteria M protein involved in outer membrane biogenesis - - - ko:K07289 - - - - ko00000 - - - AsmA,AsmA_2 k59_1033734_1 1121438.JNJA01000004_gene650 1.41e-77 239.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2WMSH@28221|Deltaproteobacteria,2M9NY@213115|Desulfovibrionales 28221|Deltaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_1341977_1 977880.RALTA_A1423 4.7e-93 286.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHGR@28216|Betaproteobacteria,1K02G@119060|Burkholderiaceae 28216|Betaproteobacteria C belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1341977_2 1121033.AUCF01000001_gene2206 0.000132 44.7 COG2267@1|root,COG2267@2|Bacteria,1NTH9@1224|Proteobacteria,2TWFW@28211|Alphaproteobacteria,2JQWG@204441|Rhodospirillales 204441|Rhodospirillales I hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1397426_1 797210.Halxa_3107 3.79e-10 59.3 COG0262@1|root,arCOG01490@2157|Archaea,2XX2J@28890|Euryarchaeota,23VTJ@183963|Halobacteria 183963|Halobacteria H Belongs to the dihydrofolate reductase family folA1 - 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 - - - DHFR_1 k59_1397426_2 497964.CfE428DRAFT_1305 1.85e-12 63.5 2DFNJ@1|root,2ZSFW@2|Bacteria,46WS2@74201|Verrucomicrobia 74201|Verrucomicrobia S SMART PUR-alpha beta gamma DNA RNA-binding - - - - - - - - - - - - PurA k59_1033749_2 1247649.D560_0391 2.42e-05 47.0 COG3221@1|root,COG3221@2|Bacteria,1MWFF@1224|Proteobacteria,2VMM9@28216|Betaproteobacteria,3T3IF@506|Alcaligenaceae 28216|Betaproteobacteria P ABC-type phosphate phosphonate transport system periplasmic component phnD - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_565137_1 631362.Thi970DRAFT_02342 1.01e-107 323.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1WVZ2@135613|Chromatiales 135613|Chromatiales E TIGRFAM glutamine synthetase, type I glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_773436_1 1123355.JHYO01000008_gene2681 3.6e-62 212.0 COG2172@1|root,COG2203@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,1PFBR@1224|Proteobacteria,2U1RE@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Sigma factor PP2C-like phosphatases rsbU - - - - - - - - - - - GAF,GAF_2,HATPase_c_2,SpoIIE k59_1035220_1 1229909.NSED_00235 2.37e-72 225.0 COG0037@1|root,arCOG00042@2157|Archaea,41S84@651137|Thaumarchaeota 651137|Thaumarchaeota D PP-loop family - - - - - - - - - - - - ATP_bind_3 k59_1035220_2 436308.Nmar_0107 2.83e-41 145.0 COG0750@1|root,arCOG04064@2157|Archaea,41SW5@651137|Thaumarchaeota 651137|Thaumarchaeota M Peptidase family M50 - - - - - - - - - - - - PDZ_2,Peptidase_M50 k59_565153_1 1229909.NSED_07150 2.83e-68 213.0 COG0189@1|root,arCOG01589@2157|Archaea,41SCQ@651137|Thaumarchaeota 651137|Thaumarchaeota H Lysine biosynthesis - - 6.3.2.43 ko:K05827 ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230 M00031 R09775 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - RimK k59_565153_2 1229909.NSED_07155 1.1e-106 315.0 COG0002@1|root,arCOG00495@2157|Archaea,41S8R@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily lysY - - ko:K05829 ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230 M00031,M00763 R09777,R10931 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1187625_1 682795.AciX8_1404 6.83e-104 325.0 COG3808@1|root,COG3808@2|Bacteria,3Y34E@57723|Acidobacteria,2JJHT@204432|Acidobacteriia 204432|Acidobacteriia C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_465189_1 671143.DAMO_1275 3.32e-77 250.0 COG0471@1|root,COG0471@2|Bacteria,2NPNA@2323|unclassified Bacteria 2|Bacteria P Sodium:sulfate symporter transmembrane region - - - ko:K03319,ko:K14445 - - - - ko00000,ko02000 2.A.47,2.A.47.1 - - Na_sulph_symp k59_20574_1 330214.NIDE2795 3.04e-84 258.0 COG4977@1|root,COG4977@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - AraC_binding,Cupin_6,HTH_18 k59_1144095_1 1318628.MARLIPOL_06959 2.93e-18 89.7 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,4658X@72275|Alteromonadaceae 1236|Gammaproteobacteria S exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - LolA_like,MMPL,Polyketide_cyc2 k59_617705_1 1430440.MGMSRv2_0400 3.16e-32 124.0 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,2TSQM@28211|Alphaproteobacteria,2JP8M@204441|Rhodospirillales 204441|Rhodospirillales J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides rnd - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_617705_2 1236542.BALM01000006_gene3184 1.16e-35 133.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria,2Q8T1@267890|Shewanellaceae 1236|Gammaproteobacteria M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0042802,GO:0044424,GO:0044464 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - iSDY_1059.SDY_4251 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_359629_1 1229909.NSED_01170 6.79e-84 251.0 COG1413@1|root,arCOG02966@2157|Archaea,41T3Y@651137|Thaumarchaeota 651137|Thaumarchaeota C HEAT repeats - - - - - - - - - - - - - k59_878824_1 1397527.Q670_12800 1.47e-67 226.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1XHFN@135619|Oceanospirillales 135619|Oceanospirillales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_307697_1 886293.Sinac_1280 9.7e-30 109.0 COG1544@1|root,COG1544@2|Bacteria,2J0UN@203682|Planctomycetes 203682|Planctomycetes J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase - - - - - - - - - - - - Ribosomal_S30AE k59_252314_1 686340.Metal_2574 3.82e-77 246.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1XDJV@135618|Methylococcales 135618|Methylococcales H Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_359636_1 367737.Abu_0619 3.57e-11 65.5 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,42SDX@68525|delta/epsilon subdivisions,2YP47@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_773483_1 247490.KSU1_B0092 9e-18 84.7 COG0480@1|root,COG0480@2|Bacteria,2IX5V@203682|Planctomycetes 203682|Planctomycetes J COG0480 Translation elongation factors - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_773483_2 868595.Desca_0165 2.53e-35 130.0 COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia,260RP@186807|Peptococcaceae 186801|Clostridia F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k59_410755_1 105559.Nwat_0964 7e-105 316.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,1WWET@135613|Chromatiales 135613|Chromatiales E PFAM Aminotransferase class I and II - - 2.6.1.17 ko:K14267 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_773495_1 765420.OSCT_2206 4.86e-14 82.0 COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,2GABQ@200795|Chloroflexi,3751C@32061|Chloroflexia 32061|Chloroflexia T histidine kinase A domain protein - - - - - - - - - - - - DUF3369,GAF,GAF_2,HATPase_c,HisKA,PAS_4 k59_724417_1 1469245.JFBG01000083_gene251 1.14e-89 280.0 COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria 1224|Proteobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_157095_1 290397.Adeh_0721 1.47e-75 248.0 COG0568@1|root,COG1196@1|root,COG0568@2|Bacteria,COG1196@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2YUHI@29|Myxococcales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_157095_2 880073.Calab_0209 7.01e-14 75.5 COG0493@1|root,COG0493@2|Bacteria 2|Bacteria C 'glutamate synthase - - 1.17.1.9,1.18.1.2,1.19.1.1,1.5.8.1,1.5.8.2,5.2.1.13 ko:K00123,ko:K00317,ko:K00528,ko:K09835 ko00630,ko00680,ko00906,ko01100,ko01110,ko01120,ko01200,map00630,map00680,map00906,map01100,map01110,map01120,map01200 M00097 R00519,R01588,R02511,R07512,R10159 RC00185,RC00556,RC00557,RC00732,RC01960,RC02796 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase,Fer4_20,NAD_binding_8,Oxidored_FMN,Pyr_redox_2 k59_366263_1 518766.Rmar_2012 1.43e-85 271.0 COG4263@1|root,COG4263@2|Bacteria,4NFNE@976|Bacteroidetes,1FIVE@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Nitrous oxide reductase nosZ - 1.7.2.4 ko:K00376 ko00910,ko01120,map00910,map01120 M00529 R02804 RC02861 ko00000,ko00001,ko00002,ko01000 - - - - k59_1410810_1 159749.E7BWD7 1.13e-75 229.0 COG0457@1|root,KOG1124@2759|Eukaryota,2XE9K@2836|Bacillariophyta 2836|Bacillariophyta S Essential for the assembly of the photosystem I (PSI) complex. May act as a chaperone-like factor to guide the assembly of the PSI subunits ycf3 - - - - - - - - - - - TPR_1,TPR_8 k59_1306344_1 472759.Nhal_0101 3.88e-70 228.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1X0AC@135613|Chromatiales 135613|Chromatiales C dihydrolipoamide dehydrogenase - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_1567558_1 1219031.BBJR01000067_gene1176 2.17e-09 60.5 COG5652@1|root,COG5652@2|Bacteria,1PJUW@1224|Proteobacteria,2VHEZ@28216|Betaproteobacteria,4ABFG@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM VanZ family protein - - - - - - - - - - - - VanZ k59_1567558_2 631362.Thi970DRAFT_03694 8.11e-12 65.5 COG0608@1|root,COG0608@2|Bacteria,1N37P@1224|Proteobacteria,1RQTR@1236|Gammaproteobacteria,1WWFV@135613|Chromatiales 135613|Chromatiales L single-stranded DNA 5'-3' exodeoxyribonuclease activity - - - - - - - - - - - - - k59_418392_1 1123401.JHYQ01000042_gene1304 5.4e-07 50.4 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,4601W@72273|Thiotrichales 72273|Thiotrichales E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_418392_2 519989.ECTPHS_11350 4.73e-109 323.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1WXGF@135613|Chromatiales 135613|Chromatiales E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_418392_3 395493.BegalDRAFT_1848 1.13e-137 397.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,4600U@72273|Thiotrichales 72273|Thiotrichales I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1306349_2 935567.JAES01000017_gene2432 3.37e-89 282.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1X2Z8@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1202064_1 1121403.AUCV01000025_gene2232 5.51e-55 184.0 COG1150@1|root,COG2181@1|root,COG1150@2|Bacteria,COG2181@2|Bacteria,1QUKA@1224|Proteobacteria,42MNE@68525|delta/epsilon subdivisions,2WIN3@28221|Deltaproteobacteria,2MHSC@213118|Desulfobacterales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain qmoC - - ko:K16887 - - - - ko00000 - - - Fer4_17,Fer4_8,Fer4_9,Nitrate_red_gam k59_888617_1 314278.NB231_00260 3.98e-116 339.0 KOG2165@1|root,2Z911@2|Bacteria,1N8JM@1224|Proteobacteria,1RR9Z@1236|Gammaproteobacteria,1WWIT@135613|Chromatiales 135613|Chromatiales S ubiquitin protein ligase binding - - - - - - - - - - - - - k59_888617_2 83219.PM02_00510 2.88e-05 47.0 COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2U59A@28211|Alphaproteobacteria,3ZW1X@60136|Sulfitobacter 28211|Alphaproteobacteria U MarC family integral membrane protein marC - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_940800_1 395493.BegalDRAFT_3417 4.24e-98 294.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,460AH@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_1045235_1 195103.CPF_2375 2.88e-12 66.6 COG1555@1|root,COG1555@2|Bacteria,1VA3W@1239|Firmicutes,24MQF@186801|Clostridia,36KSY@31979|Clostridiaceae 186801|Clostridia L Competence protein ComEA helix-hairpin-helix repeat comEA - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3,SLBB k59_1045235_2 365044.Pnap_2800 4.73e-81 253.0 COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,2VHNS@28216|Betaproteobacteria,4AAM9@80864|Comamonadaceae 28216|Betaproteobacteria H Phosphomethylpyrimidine kinase rfaE - 2.7.1.167,2.7.7.70 ko:K03272,ko:K21344 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB k59_629_1 690850.Desaf_0495 2.27e-34 129.0 COG2367@1|root,COG2367@2|Bacteria,1R6KF@1224|Proteobacteria,42YYI@68525|delta/epsilon subdivisions,2WTQR@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Beta-lactamase enzyme family - - 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2 k59_629_2 592029.DDD_1503 1.47e-08 58.2 COG0574@1|root,COG0574@2|Bacteria,4NH4R@976|Bacteroidetes,1HWKY@117743|Flavobacteriia,3HK25@363408|Nonlabens 976|Bacteroidetes G Pyruvate phosphate dikinase - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_1515201_1 743974.MBO_02155 8.94e-09 62.8 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,3NK7J@468|Moraxellaceae 1236|Gammaproteobacteria I Phospholipase D - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_1515201_2 382464.ABSI01000013_gene1503 1.67e-20 90.5 COG5660@1|root,2Z7TM@2|Bacteria 2|Bacteria S TRAP transporter T-component - - - - - - - - - - - - TAtT k59_157117_1 1236959.BAMT01000002_gene2123 1.67e-76 241.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria,2KM9S@206350|Nitrosomonadales 206350|Nitrosomonadales M Peptidoglycan polymerase that is essential for cell division ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_1306358_1 392500.Swoo_1801 1.05e-31 127.0 COG2831@1|root,COG2831@2|Bacteria,1MWWH@1224|Proteobacteria,1RREH@1236|Gammaproteobacteria,2Q9BU@267890|Shewanellaceae 1236|Gammaproteobacteria U PFAM Ig domain protein, group 1 domain protein - - - - - - - - - - - - Big_1 k59_940802_2 1117379.BABA_14202 1.23e-22 93.6 COG1545@1|root,COG1545@2|Bacteria,1V92V@1239|Firmicutes,4I6BI@91061|Bacilli,1ZJT6@1386|Bacillus 91061|Bacilli S Rubredoxin-like zinc ribbon domain (DUF35_N) - - - - - - - - - - - - DUF35_N,OB_aCoA_assoc k59_366292_1 530564.Psta_1931 9.53e-121 358.0 COG0372@1|root,COG0372@2|Bacteria,2IYFN@203682|Planctomycetes 203682|Planctomycetes H citrate synthase gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_575194_3 1229909.NSED_07420 0.000213 43.1 COG0456@1|root,arCOG00833@2157|Archaea 2157|Archaea C PFAM GCN5-related N-acetyltransferase - - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_627502_1 886293.Sinac_7073 2.67e-34 129.0 COG4301@1|root,COG4301@2|Bacteria,2IXEH@203682|Planctomycetes 203682|Planctomycetes S Histidine-specific methyltransferase, SAM-dependent - - - - - - - - - - - - Methyltransf_33 k59_261734_1 1379270.AUXF01000002_gene1749 2.48e-85 281.0 COG4888@1|root,COG4888@2|Bacteria,1ZURG@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_575196_1 1121335.Clst_0831 4.06e-58 189.0 COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,3WGIW@541000|Ruminococcaceae 186801|Clostridia IQ reductase srlD - 1.1.1.140,1.1.1.304,1.1.1.76 ko:K00068,ko:K03366 ko00051,ko00650,map00051,map00650 - R02855,R02946,R03707,R05607,R09078,R10505 RC00085,RC00205,RC00525 ko00000,ko00001,ko01000 - - - adh_short,adh_short_C2 k59_261743_1 518766.Rmar_0089 3.31e-67 228.0 COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1FIP6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Peptidase M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_52919_1 1043205.AFYF01000011_gene1404 2.35e-12 72.4 COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4FEFS@85021|Intrasporangiaceae 201174|Actinobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) menG GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_784208_1 748658.KB907320_gene898 1.48e-76 238.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,1WW4G@135613|Chromatiales 135613|Chromatiales P PFAM CBS domain - - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_1097476_1 573370.DMR_23340 6.15e-110 354.0 COG4262@1|root,COG4262@2|Bacteria,1QX9D@1224|Proteobacteria,42Q62@68525|delta/epsilon subdivisions,2WMHX@28221|Deltaproteobacteria,2M99V@213115|Desulfovibrionales 28221|Deltaproteobacteria E Spermine/spermidine synthase domain - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_261747_1 96561.Dole_1191 1.43e-91 293.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2MI4Z@213118|Desulfobacterales 28221|Deltaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_1567597_1 765914.ThisiDRAFT_1142 0.000188 43.1 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1567597_2 553385.JEMF01000019_gene1000 1.54e-36 125.0 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria,1XMBW@135619|Oceanospirillales 135619|Oceanospirillales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_366310_2 1502770.JQMG01000001_gene384 1.69e-93 283.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2VIME@28216|Betaproteobacteria,2KKHZ@206350|Nitrosomonadales 206350|Nitrosomonadales I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_888648_1 1229172.JQFA01000002_gene2812 4.26e-149 427.0 COG1062@1|root,COG1062@2|Bacteria,1G2S4@1117|Cyanobacteria,1H7TD@1150|Oscillatoriales 1117|Cyanobacteria C Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily frmA - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_888648_2 102129.Lepto7375DRAFT_3100 5.63e-49 162.0 COG0454@1|root,COG0456@2|Bacteria,1G8NU@1117|Cyanobacteria 1117|Cyanobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_470606_1 1121861.KB899945_gene3956 1.13e-53 182.0 COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,2JQU6@204441|Rhodospirillales 204441|Rhodospirillales J COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - - - - - - - - - - - Amidase k59_679803_1 1333998.M2A_0667 1.99e-110 328.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria,4BP5Q@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Thiolase, C-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_105021_1 177439.DP2823 3.76e-98 298.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2MI3G@213118|Desulfobacterales 28221|Deltaproteobacteria T response regulator receiver ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_522884_1 1379698.RBG1_1C00001G1780 7.8e-16 76.6 COG0826@1|root,COG0826@2|Bacteria,2NS1M@2323|unclassified Bacteria 2|Bacteria O peptidase U32 yegQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32,Peptidase_U32_C k59_522884_2 395493.BegalDRAFT_2665 7.67e-214 607.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,4603K@72273|Thiotrichales 72273|Thiotrichales O magnesium chelatase - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_575233_1 1163617.SCD_n00198 1.97e-52 174.0 COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,2VTXX@28216|Betaproteobacteria 28216|Betaproteobacteria K Cyclic nucleotide-monophosphate binding domain - - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1620755_1 1469245.JFBG01000013_gene1949 9.27e-96 285.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1WWUT@135613|Chromatiales 135613|Chromatiales C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_732780_1 1415780.JPOG01000001_gene493 9.57e-71 224.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,1X4YK@135614|Xanthomonadales 135614|Xanthomonadales L Transposase and inactivated derivatives, IS5 family - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_471264_1 653733.Selin_0159 1.45e-86 283.0 COG0458@1|root,COG0458@2|Bacteria 2|Bacteria F carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS k59_157674_1 1263831.F543_2770 1.54e-48 164.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1Y84G@135625|Pasteurellales 135625|Pasteurellales H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_210348_1 1288494.EBAPG3_2370 5.8e-45 164.0 28H91@1|root,2Z7KU@2|Bacteria,1R4NB@1224|Proteobacteria,2VS45@28216|Betaproteobacteria,373Z4@32003|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1046131_1 243233.MCA0312 1.42e-37 138.0 COG3471@1|root,COG3471@2|Bacteria,1PR6A@1224|Proteobacteria,1T9ZZ@1236|Gammaproteobacteria,1XGSP@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF541) - - - - - - - - - - - - SIMPL k59_1046131_2 420324.KI911961_gene1915 6.83e-83 255.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2TR3G@28211|Alphaproteobacteria,1JRBP@119045|Methylobacteriaceae 28211|Alphaproteobacteria C PFAM aldo keto reductase MA20_21005 - 1.1.1.91 ko:K05882 - - - - ko00000,ko01000 - - - Aldo_ket_red k59_1098426_1 469383.Cwoe_5786 2.16e-33 122.0 COG3871@1|root,COG3871@2|Bacteria,2I2QZ@201174|Actinobacteria,4CQ6F@84995|Rubrobacteria 84995|Rubrobacteria S Pfam:Pyridox_oxidase - - - - - - - - - - - - Putative_PNPOx k59_889531_2 414684.RC1_1075 1.22e-110 344.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQ9H@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_785239_1 1177928.TH2_19944 7.33e-107 329.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2JPCQ@204441|Rhodospirillales 204441|Rhodospirillales P COG2217 Cation transport ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_1515761_1 1121405.dsmv_1445 2.38e-82 261.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2MI6Q@213118|Desulfobacterales 28221|Deltaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_1307077_1 330214.NIDE4155 2.76e-59 197.0 293H1@1|root,2ZQZ6@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_732792_2 373903.Hore_15390 9.46e-57 184.0 COG0689@1|root,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,25E5P@186801|Clostridia,3WAIM@53433|Halanaerobiales 186801|Clostridia J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56,3.6.1.66 ko:K00989,ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000,ko03016 - - - Ham1p_like,RNase_PH,RNase_PH_C k59_210358_1 864069.MicloDRAFT_00060060 6.78e-105 322.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,1JSG5@119045|Methylobacteriaceae 28211|Alphaproteobacteria I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_314863_1 1137799.GZ78_21280 2.12e-36 132.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1XI8U@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_1255275_1 290402.Cbei_4808 5.87e-15 80.1 COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,36E1T@31979|Clostridiaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - GGDEF,HD,HD_5,PAS,PAS_4,PAS_8 k59_1359647_2 1038860.AXAP01000129_gene4295 4.64e-45 156.0 COG2267@1|root,COG2267@2|Bacteria,1QU7K@1224|Proteobacteria,2U0H3@28211|Alphaproteobacteria,3JR1E@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Serine aminopeptidase, S33 - - 2.7.10.2,3.3.2.9 ko:K01253,ko:K08253 ko00980,ko04976,ko05204,map00980,map04976,map05204 - R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443 RC01447,RC01728,RC01764,RC02528 ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_1307085_1 382640.BT_1560 4.51e-70 231.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TR1I@28211|Alphaproteobacteria,48TMB@772|Bartonellaceae 28211|Alphaproteobacteria E Thiamine pyrophosphate enzyme, N-terminal TPP binding domain ilvI - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1515768_1 1123368.AUIS01000009_gene2439 5.21e-171 502.0 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria 1236|Gammaproteobacteria G 4-alpha-glucanotransferase malQ - 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Glyco_hydro_77 k59_523802_1 400682.PAC_15704302 1.11e-38 130.0 COG2920@1|root,2S4QR@2759|Eukaryota,3A791@33154|Opisthokonta,3BTV4@33208|Metazoa 33208|Metazoa P DsrC like protein - - - - - - - - - - - - DsrC k59_523802_2 1249627.D779_2147 1.77e-38 131.0 COG2168@1|root,COG2168@2|Bacteria,1NGF3@1224|Proteobacteria,1SGPI@1236|Gammaproteobacteria,1WYI4@135613|Chromatiales 135613|Chromatiales P sulfur relay protein TusB DsrH - - - ko:K07237 ko04122,map04122 - - - ko00000,ko00001,ko03016 - - - DsrH k59_523802_3 864051.BurJ1DRAFT_3333 6.05e-26 99.0 COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,2VSQ5@28216|Betaproteobacteria 28216|Betaproteobacteria P Sulfur relay protein TusC DsrF - - - ko:K07236 ko04122,map04122 - - - ko00000,ko00001,ko03016 - - - DrsE k59_105636_2 497964.CfE428DRAFT_4831 3.37e-55 190.0 COG0821@1|root,COG0821@2|Bacteria,46SEF@74201|Verrucomicrobia 74201|Verrucomicrobia I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_889554_1 1249627.D779_0750 1.26e-98 301.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WX6V@135613|Chromatiales 135613|Chromatiales E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1620792_1 1500893.JQNB01000001_gene1399 8.01e-82 250.0 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1X4H1@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_1620792_2 1049564.TevJSym_ao00670 7.78e-21 85.1 COG2921@1|root,COG2921@2|Bacteria,1PJDT@1224|Proteobacteria,1SXYR@1236|Gammaproteobacteria,1J7A1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0250 family - - - - - - - - - - - - DUF493 k59_367208_1 1125863.JAFN01000001_gene1535 1.62e-83 263.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42MZZ@68525|delta/epsilon subdivisions,2WIQI@28221|Deltaproteobacteria 28221|Deltaproteobacteria H MoeA domain protein domain I and II moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_785274_3 1040989.AWZU01000069_gene3290 1.28e-34 131.0 28JXP@1|root,2Z9N4@2|Bacteria,1MXG4@1224|Proteobacteria,2TSXI@28211|Alphaproteobacteria,3JSBT@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family MA20_24470 - - - - - - - - - - - Peptidase_C92 k59_889564_2 697303.Thewi_0513 1.38e-41 147.0 COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AMT@186801|Clostridia,42FWJ@68295|Thermoanaerobacterales 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02025,ko:K10237 ko02010,map02010 M00204,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.17 - - BPD_transp_1 k59_1585757_2 888056.HMPREF9062_0388 7.69e-30 117.0 COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4D5FJ@85005|Actinomycetales 201174|Actinobacteria C Radical SAM superfamily pqqE - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM k59_1486039_1 1116472.MGMO_42c00110 5.43e-111 329.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1THGR@1236|Gammaproteobacteria,1XDV9@135618|Methylococcales 135618|Methylococcales E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_540930_2 436308.Nmar_1528 3.5e-18 89.0 arCOG07561@1|root,arCOG07561@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - TSP_3,VWA k59_1638995_1 1123360.thalar_02885 8.84e-256 717.0 COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2U068@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome C and Quinol oxidase polypeptide I - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_750053_1 330214.NIDE3615 2.41e-117 350.0 COG2081@1|root,COG2081@2|Bacteria,3J12U@40117|Nitrospirae 40117|Nitrospirae S HI0933-like protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_854953_1 1207063.P24_13228 2.4e-42 150.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U6EY@28211|Alphaproteobacteria,2JRWX@204441|Rhodospirillales 204441|Rhodospirillales M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_D23 k59_593508_1 649638.Trad_2961 3.09e-87 270.0 COG0366@1|root,COG0366@2|Bacteria,1WIU5@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G PFAM alpha amylase, catalytic - - 3.2.1.133,3.2.1.135,3.2.1.54 ko:K01208 ko00500,ko01100,map00500,map01100 - R02112,R03122,R11262 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3459,Malt_amylase_C k59_124870_1 1229909.NSED_02630 3.02e-133 385.0 COG1064@1|root,arCOG01455@2157|Archaea,41SA9@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_593515_1 2340.JV46_08040 2.35e-70 219.0 COG0678@1|root,COG0695@1|root,COG0678@2|Bacteria,COG0695@2|Bacteria,1MU0H@1224|Proteobacteria,1RRFB@1236|Gammaproteobacteria,1J5WI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0678 Peroxiredoxin VY92_02980 - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - Glutaredoxin,Redoxin k59_699970_1 1265490.JHVY01000015_gene188 1.69e-20 95.1 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Thioredoxin ybbN GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0061077 - ko:K03671,ko:K05838 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_1116151_1 478741.JAFS01000002_gene530 9.33e-31 113.0 COG0450@1|root,COG0450@2|Bacteria,46TAE@74201|Verrucomicrobia 74201|Verrucomicrobia O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_1116151_2 269084.syc1395_c 5.91e-52 170.0 COG0783@1|root,COG0783@2|Bacteria,1G586@1117|Cyanobacteria,1H0B1@1129|Synechococcus 1117|Cyanobacteria P Belongs to the Dps family dps - - ko:K04047 - - - - ko00000,ko03036 - - - Ferritin k59_1486981_1 1049564.TevJSym_ao00020 7.24e-62 205.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1J4IU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases visC - - ko:K03184,ko:K03185,ko:K18800 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04987,R04989,R06146,R08768,R08773,R08775 RC00046,RC01254,RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3,SE k59_1322637_1 465541.ATCJ01000005_gene6662 4.67e-24 106.0 COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria 201174|Actinobacteria G hydrolase, family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,Ricin_B_lectin k59_809387_1 1173025.GEI7407_0336 8.12e-80 271.0 COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H799@1150|Oscillatoriales 1117|Cyanobacteria M Tetratricopeptide repeat - - - - - - - - - - - - DUF4915,Glyco_transf_9,Glycos_transf_1,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_809387_2 1246459.KB898358_gene3701 2.45e-173 510.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,4B8TC@82115|Rhizobiaceae 28211|Alphaproteobacteria E Belongs to the GcvT family Sardh GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006575,GO:0006576,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008480,GO:0009056,GO:0009063,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019695,GO:0019752,GO:0019842,GO:0031406,GO:0031974,GO:0033218,GO:0034641,GO:0035999,GO:0036094,GO:0042133,GO:0042135,GO:0042219,GO:0042402,GO:0042426,GO:0042558,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046483,GO:0046653,GO:0046997,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072341,GO:0097159,GO:0097164,GO:1901052,GO:1901053,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.5.3.19 ko:K19191 ko00760,ko01120,map00760,map01120 - R10102 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO,FAO_M,GCV_T,GCV_T_C k59_438323_2 1267533.KB906741_gene488 4.02e-10 60.1 COG0384@1|root,COG0384@2|Bacteria,3Y7JN@57723|Acidobacteria 57723|Acidobacteria S PFAM Phenazine biosynthesis PhzC PhzF protein - - - - - - - - - - - - PhzC-PhzF k59_493421_1 1232410.KI421422_gene2063 3.59e-84 269.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2WJP6@28221|Deltaproteobacteria,43S1W@69541|Desulfuromonadales 28221|Deltaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - iAF987.Gmet_1487 GATase_6,SIS k59_493421_2 1397666.RS24_01357 2.42e-11 62.8 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,4BPDZ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_959007_1 1049564.TevJSym_aq00670 2.82e-79 240.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,1J4WI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfA - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr k59_750688_2 7213.XP_004533050.1 1.18e-61 201.0 COG1028@1|root,KOG0725@2759|Eukaryota,38GHU@33154|Opisthokonta,3CPTB@33208|Metazoa,3E5YB@33213|Bilateria,42B0Y@6656|Arthropoda,3T0EG@50557|Insecta 33208|Metazoa Q Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_1224316_1 1444711.CCJF01000003_gene91 5.29e-193 553.0 COG0058@1|root,COG0058@2|Bacteria,2JFEH@204428|Chlamydiae 204428|Chlamydiae G Carbohydrate phosphorylase glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_541474_1 237368.SCABRO_03848 1.01e-88 268.0 COG1127@1|root,COG1127@2|Bacteria,2J2WI@203682|Planctomycetes 203682|Planctomycetes Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_438348_1 396588.Tgr7_1012 5.75e-92 282.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1WVZB@135613|Chromatiales 135613|Chromatiales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_1011870_2 126957.SMAR006051-PA 6.23e-42 159.0 COG0175@1|root,COG1230@1|root,KOG1483@2759|Eukaryota,KOG2644@2759|Eukaryota,38CHY@33154|Opisthokonta,3BC1J@33208|Metazoa,3CSJR@33213|Bilateria,41V1D@6656|Arthropoda 33208|Metazoa P Cation transmembrane transporter activity. It is involved in the biological process described with transmembrane transport SLC30A1 GO:0000041,GO:0001505,GO:0001701,GO:0003674,GO:0005215,GO:0005246,GO:0005385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005783,GO:0005794,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0006829,GO:0006873,GO:0006874,GO:0006875,GO:0006882,GO:0006950,GO:0007275,GO:0008150,GO:0008200,GO:0008324,GO:0009636,GO:0009790,GO:0009792,GO:0009966,GO:0009967,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010312,GO:0010646,GO:0010647,GO:0010648,GO:0010959,GO:0012505,GO:0015075,GO:0015318,GO:0015562,GO:0015691,GO:0016020,GO:0016021,GO:0016247,GO:0016248,GO:0016323,GO:0016324,GO:0019725,GO:0019855,GO:0019899,GO:0019900,GO:0019901,GO:0022857,GO:0022883,GO:0022890,GO:0023051,GO:0023056,GO:0023057,GO:0030001,GO:0030003,GO:0030315,GO:0031090,GO:0031224,GO:0031965,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0032879,GO:0034220,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040026,GO:0040028,GO:0042221,GO:0042383,GO:0042592,GO:0043009,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043269,GO:0043271,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0045177,GO:0046578,GO:0046579,GO:0046583,GO:0046686,GO:0046873,GO:0046915,GO:0046916,GO:0046928,GO:0046929,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048580,GO:0048582,GO:0048583,GO:0048584,GO:0048856,GO:0048878,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050804,GO:0050805,GO:0050896,GO:0051046,GO:0051048,GO:0051049,GO:0051051,GO:0051056,GO:0051057,GO:0051094,GO:0051179,GO:0051234,GO:0051239,GO:0051240,GO:0051588,GO:0051589,GO:0051716,GO:0051924,GO:0051926,GO:0055065,GO:0055069,GO:0055074,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0060341,GO:0061062,GO:0061063,GO:0061088,GO:0061687,GO:0065007,GO:0065008,GO:0065009,GO:0070509,GO:0070574,GO:0070838,GO:0070887,GO:0071241,GO:0071248,GO:0071294,GO:0071577,GO:0071579,GO:0071580,GO:0071581,GO:0071582,GO:0071583,GO:0071584,GO:0071585,GO:0071944,GO:0072503,GO:0072507,GO:0072509,GO:0072511,GO:0090279,GO:0090281,GO:0097501,GO:0098590,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0098771,GO:0098772,GO:0099106,GO:0099177,GO:1902531,GO:1902533,GO:1903530,GO:1903531,GO:1904062,GO:1904063,GO:1990170,GO:1990359,GO:2000026 - ko:K14688 ko04978,map04978 - - - ko00000,ko00001,ko02000 2.A.4.2 - - Cation_efflux k59_1064796_1 1286106.MPL1_12508 8.79e-140 404.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1RWC8@1236|Gammaproteobacteria,460AJ@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - LeuA_dimer,PALP k59_1166287_1 519989.ECTPHS_04054 1.44e-65 215.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,1WWMC@135613|Chromatiales 135613|Chromatiales E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_1166287_2 1238190.AMQY01000014_gene808 0.000975 43.9 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1XI9W@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_855627_1 290397.Adeh_1428 1.2e-40 152.0 COG0343@1|root,COG4121@1|root,COG0343@2|Bacteria,COG4121@2|Bacteria,1MUCA@1224|Proteobacteria,42YYV@68525|delta/epsilon subdivisions,2WTRR@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) - - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - Methyltransf_30,TGT k59_1433303_1 56780.SYN_01524 5.92e-75 241.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2MR54@213462|Syntrophobacterales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_1279293_1 1297742.A176_06152 2.71e-30 117.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,42MW8@68525|delta/epsilon subdivisions,2WKI6@28221|Deltaproteobacteria,2YY45@29|Myxococcales 28221|Deltaproteobacteria I Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus phaC - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1279293_2 485916.Dtox_1180 2.58e-36 130.0 COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,260VS@186807|Peptococcaceae 186801|Clostridia IQ PFAM short chain dehydrogenase fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_388203_1 237368.SCABRO_03897 1.19e-50 168.0 COG4976@1|root,COG4976@2|Bacteria 2|Bacteria O Methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_23 k59_388203_2 1234364.AMSF01000016_gene1545 1.45e-11 64.3 COG0475@1|root,COG0475@2|Bacteria,1RB9F@1224|Proteobacteria,1S398@1236|Gammaproteobacteria,1X5GT@135614|Xanthomonadales 135614|Xanthomonadales P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_77671_1 103733.JNYO01000063_gene3101 2.22e-41 154.0 COG2374@1|root,COG2374@2|Bacteria,2I2E0@201174|Actinobacteria,4DZPN@85010|Pseudonocardiales 201174|Actinobacteria S Endonuclease/Exonuclease/phosphatase family - - - ko:K07004 - - - - ko00000 - - - Exo_endo_phos,LTD k59_1433316_1 33876.JNXY01000015_gene7499 7.18e-16 81.6 COG3437@1|root,COG3437@2|Bacteria,2IKC2@201174|Actinobacteria,4DMAV@85008|Micromonosporales 201174|Actinobacteria KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_907959_1 1121918.ARWE01000001_gene3534 7.8e-44 169.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,43S7U@69541|Desulfuromonadales 28221|Deltaproteobacteria M Transglycosylase mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_750722_1 1234364.AMSF01000059_gene942 1.11e-12 75.5 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,1X30D@135614|Xanthomonadales 135614|Xanthomonadales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_281226_1 991905.SL003B_3826 2.19e-92 298.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria,4BPQH@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Putative amidoligase enzyme (DUF2126) MA20_16195 - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_438367_1 296591.Bpro_2557 1.11e-42 151.0 COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2VIA4@28216|Betaproteobacteria,4ADRI@80864|Comamonadaceae 28216|Betaproteobacteria NU type II secretion system protein tadC - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF k59_228479_1 765420.OSCT_1192 1.87e-36 132.0 COG0604@1|root,COG0604@2|Bacteria,2G9Z7@200795|Chloroflexi,377GH@32061|Chloroflexia 32061|Chloroflexia C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_1116745_1 649638.Trad_0988 4.39e-82 259.0 COG0129@1|root,COG0129@2|Bacteria,1WIP6@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_1116745_2 706587.Desti_3917 1.06e-70 227.0 COG1597@1|root,COG1597@2|Bacteria,1RIPU@1224|Proteobacteria,43DQE@68525|delta/epsilon subdivisions 1224|Proteobacteria I Diacylglycerol kinase catalytic domain - - - - - - - - - - - - DAGK_cat k59_1639991_1 880073.Calab_3009 6.55e-08 56.6 COG2208@1|root,COG2208@2|Bacteria,2NQW9@2323|unclassified Bacteria 2|Bacteria KT Sigma factor PP2C-like phosphatases rsbU - 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 - - - CHASE2,GAF_2,HATPase_c_2,SpoIIE k59_1322687_1 1313172.YM304_12020 5.03e-09 58.5 COG3675@1|root,COG3675@2|Bacteria,2HBD6@201174|Actinobacteria 201174|Actinobacteria I Lipase (class 3) - - 3.1.1.3 ko:K01046 ko00561,ko01100,map00561,map01100 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000 - - - Lipase_3 k59_9077_1 439235.Dalk_3628 2.32e-110 333.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2WIK7@28221|Deltaproteobacteria,2MIHR@213118|Desulfobacterales 28221|Deltaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1011896_1 436308.Nmar_1713 4.38e-75 229.0 COG1136@1|root,arCOG00922@2157|Archaea,41T2R@651137|Thaumarchaeota 651137|Thaumarchaeota E ABC-type antimicrobial peptide transport system, ATPase component - - - ko:K02003,ko:K09810 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 - - ABC_tran k59_1279345_2 1232410.KI421425_gene1546 4.07e-74 228.0 COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,42TN7@68525|delta/epsilon subdivisions,2WQK7@28221|Deltaproteobacteria,43TGA@69541|Desulfuromonadales 28221|Deltaproteobacteria U MotA/TolQ/ExbB proton channel family - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_750741_1 1288494.EBAPG3_26860 2.81e-21 90.9 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2WEDQ@28216|Betaproteobacteria,37232@32003|Nitrosomonadales 28216|Betaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component oppB - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_750741_2 1049564.TevJSym_au00330 2.73e-49 174.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1J5J7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle hbpA - - - - - - - - - - - SBP_bac_5 k59_809481_2 1121935.AQXX01000144_gene4418 6.63e-39 147.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria,1XHEU@135619|Oceanospirillales 135619|Oceanospirillales S TRAP transporter, 4TM 12TM fusion protein - - - - - - - - - - - - DUF3394,DctM k59_438382_2 316274.Haur_0754 8.85e-11 63.5 COG0805@1|root,COG0805@2|Bacteria,2G6SP@200795|Chloroflexi,375NQ@32061|Chloroflexia 32061|Chloroflexia U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_1322693_1 247633.GP2143_17451 1.66e-122 364.0 COG3173@1|root,COG3173@2|Bacteria,1MY0Y@1224|Proteobacteria,1S3A0@1236|Gammaproteobacteria,1JA5F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_493526_1 132113.XP_003494294.1 2.83e-10 61.2 2E0SH@1|root,2S868@2759|Eukaryota,3A9FW@33154|Opisthokonta,3BUAQ@33208|Metazoa,3DD4V@33213|Bilateria,427UC@6656|Arthropoda,3SQXZ@50557|Insecta 33208|Metazoa O Magnesium chelatase, subunit ChlI - - - - - - - - - - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_700677_1 485918.Cpin_1365 1.64e-05 52.4 COG0392@1|root,COG0392@2|Bacteria 2|Bacteria M lysyltransferase activity - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_1442704_1 626418.bglu_2p1020 2.84e-17 80.1 COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,2VQQD@28216|Betaproteobacteria 28216|Betaproteobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1442704_2 76114.ebA4360 3.57e-36 132.0 COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,2VKSA@28216|Betaproteobacteria,2KYDG@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF3641) - - - - - - - - - - - - DUF3641,Radical_SAM k59_662374_1 395493.BegalDRAFT_1363 7.88e-37 137.0 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,460RY@72273|Thiotrichales 72273|Thiotrichales S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_1534246_2 1122604.JONR01000016_gene4444 3.56e-27 107.0 COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria,1X6EE@135614|Xanthomonadales 135614|Xanthomonadales S haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_915648_1 1278073.MYSTI_06380 2.22e-106 316.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2YWXD@29|Myxococcales 28221|Deltaproteobacteria NU twitching motility protein pilT-4 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1019093_2 1121937.AUHJ01000010_gene1607 1.43e-51 170.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,464N4@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_235625_1 247490.KSU1_C1305 2.27e-171 496.0 COG0296@1|root,COG0296@2|Bacteria,2IXS1@203682|Planctomycetes 203682|Planctomycetes G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_1442713_1 1123037.AUDE01000023_gene2787 5.76e-05 50.1 2E3AK@1|root,30JD7@2|Bacteria,4NPG4@976|Bacteroidetes,1I2KR@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1650152_1 1278309.KB907099_gene2911 4.09e-98 302.0 COG2132@1|root,COG2132@2|Bacteria 2|Bacteria Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3,TAT_signal k59_1384163_2 1449353.JQMQ01000005_gene5760 6.71e-07 55.1 COG1595@1|root,COG1595@2|Bacteria,2GM3E@201174|Actinobacteria 201174|Actinobacteria K belongs to the sigma-70 factor family, ECF subfamily - - - - - - - - - - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_548586_1 1537917.JU82_10600 1.72e-45 158.0 COG0723@1|root,COG0723@2|Bacteria,1MZ7A@1224|Proteobacteria,42N9F@68525|delta/epsilon subdivisions,2YNBZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_1233262_1 986075.CathTA2_2110 4.53e-21 91.3 COG2057@1|root,COG2057@2|Bacteria,1V0R2@1239|Firmicutes,4IRNR@91061|Bacilli 91061|Bacilli I Coenzyme A transferase - - 2.8.3.12 ko:K01040 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_235646_1 1384054.N790_08855 2.14e-30 120.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1X46J@135614|Xanthomonadales 135614|Xanthomonadales FP Belongs to the GppA Ppx family ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_235646_2 1122604.JONR01000049_gene744 3.82e-55 174.0 COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,1S675@1236|Gammaproteobacteria,1X6E5@135614|Xanthomonadales 135614|Xanthomonadales C Iron-sulfur cluster insertion protein ErpA erpA GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:1901564 - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_548594_1 1049564.TevJSym_ad00120 1.03e-78 260.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1J4MP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind k59_915685_1 1270196.JCKI01000004_gene1034 9.19e-53 182.0 COG4591@1|root,COG4591@2|Bacteria,4PMEI@976|Bacteroidetes,1IQUB@117747|Sphingobacteriia 976|Bacteroidetes M Permease - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_394188_1 187272.Mlg_1944 2e-77 252.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales 135613|Chromatiales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_503502_1 472759.Nhal_2359 3.38e-117 357.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_1328805_1 58123.JOFJ01000003_gene2074 1.89e-62 204.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4EHPD@85012|Streptosporangiales 201174|Actinobacteria Q Cytochrome P450 cyp123A3 GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616,GO:1902652 - - - - - - - - - - p450 k59_1650194_1 882082.SaccyDRAFT_3715 1.8e-13 69.3 COG1024@1|root,COG1024@2|Bacteria,2I9VC@201174|Actinobacteria,4DX6Z@85010|Pseudonocardiales 201174|Actinobacteria I PFAM Enoyl-CoA hydratase isomerase echA3 - - - - - - - - - - - ECH_1 k59_707732_1 671143.DAMO_0487 3.17e-112 330.0 COG1023@1|root,COG1023@2|Bacteria,2NP1I@2323|unclassified Bacteria 2|Bacteria G 6-phosphogluconate dehydrogenase, C-terminal domain gnd - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 k59_1534276_1 1236542.BALM01000042_gene4047 1.75e-38 131.0 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,1S3Z3@1236|Gammaproteobacteria,2QBN7@267890|Shewanellaceae 1236|Gammaproteobacteria J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_1534276_2 1121935.AQXX01000091_gene3782 1.5e-37 127.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,1XKR2@135619|Oceanospirillales 135619|Oceanospirillales J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_1534276_3 1335757.SPICUR_08245 5.5e-10 55.5 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,1WZ6K@135613|Chromatiales 135613|Chromatiales J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_341218_1 768671.ThimaDRAFT_1383 1.05e-14 78.2 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_446875_1 671143.DAMO_1250 3.89e-112 342.0 COG0156@1|root,COG0156@2|Bacteria,2NNMX@2323|unclassified Bacteria 2|Bacteria H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47,6.2.1.14 ko:K00639,ko:K00652,ko:K01906 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03209,R03210,R10124 RC00004,RC00014,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1019133_1 1123400.KB904780_gene1824 4.87e-58 192.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,45ZMS@72273|Thiotrichales 72273|Thiotrichales M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_757931_1 1217718.ALOU01000047_gene3817 5.11e-20 86.3 COG4221@1|root,COG4221@2|Bacteria,1MWXS@1224|Proteobacteria,2VHSZ@28216|Betaproteobacteria,1K249@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_757931_2 1424334.W822_06920 2.66e-98 292.0 COG1011@1|root,COG1011@2|Bacteria,1NCRU@1224|Proteobacteria,2VKXE@28216|Betaproteobacteria,3T5P7@506|Alcaligenaceae 28216|Betaproteobacteria S Haloacid dehalogenase-like hydrolase - - 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 k59_394205_1 247634.GPB2148_187 1.55e-23 103.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_1019138_1 765911.Thivi_2459 4.39e-47 164.0 COG2863@1|root,COG2863@2|Bacteria,1R6DK@1224|Proteobacteria,1S0NK@1236|Gammaproteobacteria,1WWZZ@135613|Chromatiales 135613|Chromatiales C PFAM Cytochrome C - - - - - - - - - - - - Cytochrom_C k59_1534290_1 700598.Niako_4818 2.4e-51 176.0 COG2072@1|root,COG2072@2|Bacteria,4NGC0@976|Bacteroidetes,1IXN7@117747|Sphingobacteriia 976|Bacteroidetes C Flavin-binding monooxygenase-like - - 1.14.13.168 ko:K11816 ko00380,ko01100,map00380,map01100 - R10181 RC00866 ko00000,ko00001,ko01000 - - - FMO-like,Pyr_redox_3 k59_1289471_1 330214.NIDE0809 5.57e-67 216.0 COG2706@1|root,COG2706@2|Bacteria 2|Bacteria G 6-phosphogluconolactonase activity - - - - - - - - - - - - FG-GAP,VCBS k59_1442761_1 1265505.ATUG01000001_gene4066 7.3e-13 75.9 COG0421@1|root,COG0421@2|Bacteria,1R09C@1224|Proteobacteria,42YKN@68525|delta/epsilon subdivisions,2X800@28221|Deltaproteobacteria,2MJY9@213118|Desulfobacterales 28221|Deltaproteobacteria E Tetratricopeptide repeat - - - - - - - - - - - - - k59_1442762_1 268407.PWYN_18625 1.44e-69 236.0 COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,4H9WW@91061|Bacilli,26R54@186822|Paenibacillaceae 91061|Bacilli L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_12961_1 219305.MCAG_01348 3.03e-14 71.6 COG2085@1|root,COG2085@2|Bacteria,2GMZ5@201174|Actinobacteria,4DBGU@85008|Micromonosporales 201174|Actinobacteria S NADPH-dependent F420 reductase - - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored k59_12961_2 1131269.AQVV01000011_gene2520 3.47e-33 118.0 COG3536@1|root,COG3536@2|Bacteria 2|Bacteria S Protein of unknown function (DUF971) - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - DUF971 k59_12961_3 903818.KI912269_gene21 3e-13 68.6 COG0634@1|root,COG0634@2|Bacteria,3Y2FD@57723|Acidobacteria 57723|Acidobacteria F Belongs to the purine pyrimidine phosphoribosyltransferase family - - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_757949_1 1120983.KB894571_gene2092 2.69e-105 313.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,1JNPS@119043|Rhodobiaceae 28211|Alphaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_179419_1 497964.CfE428DRAFT_4093 3.09e-91 297.0 COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,46SAP@74201|Verrucomicrobia 74201|Verrucomicrobia CE Proline dehydrogenase - - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_1384218_1 1250232.JQNJ01000001_gene1659 2.82e-38 137.0 COG3279@1|root,COG3279@2|Bacteria 2|Bacteria KT phosphorelay signal transduction system - - - - - - - - - - - - LytTR,Response_reg k59_1124471_1 82654.Pse7367_3687 2.65e-08 55.1 COG5606@1|root,COG5606@2|Bacteria,1G9DK@1117|Cyanobacteria 1117|Cyanobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_37 k59_446909_1 1121918.ARWE01000001_gene2828 4.98e-09 61.6 COG5373@1|root,COG5373@2|Bacteria,1QZY0@1224|Proteobacteria,42XBF@68525|delta/epsilon subdivisions,2WSP1@28221|Deltaproteobacteria,43VT6@69541|Desulfuromonadales 28221|Deltaproteobacteria S Type II secretion system protein B - - - ko:K02451 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - T2SSB k59_1593661_1 378806.STAUR_6385 2.09e-11 65.1 28S5K@1|root,2ZEH5@2|Bacteria,1PW2U@1224|Proteobacteria,434UQ@68525|delta/epsilon subdivisions,2WZ5T@28221|Deltaproteobacteria,2Z1DY@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (FYDLN_acid) - - - - - - - - - - - - FYDLN_acid k59_503563_1 861299.J421_3816 3.42e-154 452.0 COG0366@1|root,COG0366@2|Bacteria 2|Bacteria G hydrolase activity, hydrolyzing O-glycosyl compounds glgE - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3416 k59_179426_1 1463861.JNXE01000053_gene672 4.96e-11 65.1 COG0654@1|root,COG0654@2|Bacteria,2GK88@201174|Actinobacteria 201174|Actinobacteria CH PFAM monooxygenase FAD-binding mhpA - 1.14.13.219 ko:K16022,ko:K20943 ko00362,ko01051,ko01052,ko01120,map00362,map01051,map01052,map01120 - R05249 RC00046 ko00000,ko00001,ko01000 - - - FAD_binding_3 k59_707779_1 203122.Sde_0739 2.85e-55 188.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,4658B@72275|Alteromonadaceae 1236|Gammaproteobacteria M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_1233334_2 997353.HMPREF9144_2672 1.18e-17 78.6 COG0713@1|root,COG0713@2|Bacteria,4NTZ1@976|Bacteroidetes,2FU4K@200643|Bacteroidia 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_1233334_3 398767.Glov_3129 2.11e-07 53.5 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,42RES@68525|delta/epsilon subdivisions,2WSB9@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_915754_1 1121405.dsmv_2623 4.72e-37 140.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MI1N@213118|Desulfobacterales 28221|Deltaproteobacteria T sigma-54 factor interaction domain-containing protein - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_87413_2 410359.Pcal_0381 2.37e-06 53.9 arCOG00632@1|root,arCOG00632@2157|Archaea 2157|Archaea P Domain in cystathionine beta-synthase and other proteins. - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - CBS,MFS_1,Sugar_tr k59_134159_1 1122604.JONR01000043_gene3177 1.86e-15 76.6 COG5488@1|root,COG5488@2|Bacteria,1N9B7@1224|Proteobacteria,1TKB8@1236|Gammaproteobacteria,1X8KZ@135614|Xanthomonadales 135614|Xanthomonadales S Integral membrane protein (DUF2244) - - - - - - - - - - - - DUF2244 k59_341290_1 1121035.AUCH01000021_gene2712 6.31e-13 70.9 COG1408@1|root,COG1408@2|Bacteria,1QW5K@1224|Proteobacteria 1224|Proteobacteria S metallophosphoesterase - - - - - - - - - - - - Metallophos k59_1019170_1 1267535.KB906767_gene905 9.57e-75 254.0 COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,3Y6YC@57723|Acidobacteria 57723|Acidobacteria S Putative glutamine amidotransferase - - - - - - - - - - - - GATase1_like k59_134163_1 631362.Thi970DRAFT_02296 3.17e-81 263.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1WWN6@135613|Chromatiales 135613|Chromatiales E Extracellular solute-binding protein, family 5 - - - - - - - - - - - - SBP_bac_5 k59_819611_1 393595.ABO_0210 6.69e-80 248.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1XHR1@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.3.1.1,2.7.2.8 ko:K00930,ko:K22478 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00259,R02649 RC00002,RC00004,RC00043,RC00064 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_1498418_1 391625.PPSIR1_16240 5.29e-72 228.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YUJ9@29|Myxococcales 28221|Deltaproteobacteria T Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_1385146_1 1289387.AUKW01000004_gene1473 3.95e-13 70.9 COG1115@1|root,COG1115@2|Bacteria,2GIU2@201174|Actinobacteria 201174|Actinobacteria E amino acid carrier protein - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_1385146_2 305900.GV64_02435 1.25e-162 482.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,1XH8V@135619|Oceanospirillales 135619|Oceanospirillales S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_1498422_1 313628.LNTAR_13152 7.81e-46 167.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - - - - - - - - - - Laminin_G_3,PSCyt1,PSCyt2,PSD1 k59_758924_2 1211813.CAPH01000018_gene939 1.43e-19 88.6 COG0457@1|root,COG0457@2|Bacteria,4NFIY@976|Bacteroidetes,2FMXX@200643|Bacteroidia,22UVG@171550|Rikenellaceae 976|Bacteroidetes S Peptidase family M49 - - 3.4.14.4 ko:K01277 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M49 k59_967515_1 1242864.D187_003418 7.73e-15 74.7 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2WJ8Q@28221|Deltaproteobacteria,2YUHC@29|Myxococcales 28221|Deltaproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_967515_2 545264.KB898750_gene209 1.09e-91 274.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,1WW24@135613|Chromatiales 135613|Chromatiales OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_967515_3 478741.JAFS01000001_gene1804 6.36e-09 60.8 COG0544@1|root,COG0544@2|Bacteria,46SJZ@74201|Verrucomicrobia,37G61@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_1594647_1 204669.Acid345_2966 1.05e-94 290.0 COG2079@1|root,COG2079@2|Bacteria,3Y5N1@57723|Acidobacteria,2JK64@204432|Acidobacteriia 204432|Acidobacteriia S MmgE/PrpD family - - 4.2.1.79 ko:K01720 ko00640,map00640 - R04424 RC01152 ko00000,ko00001,ko01000 - - - MmgE_PrpD k59_1134703_1 1229909.NSED_00830 3.49e-81 259.0 COG1042@1|root,arCOG01340@2157|Archaea,41S6N@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18593 ko00720,ko01120,map00720,map01120 - R10758 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_557121_1 1379270.AUXF01000002_gene1443 2.25e-13 75.1 COG0823@1|root,COG0823@2|Bacteria,1ZTFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 k59_97789_1 56780.SYN_02443 9.36e-27 107.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,42UBZ@68525|delta/epsilon subdivisions,2WNB6@28221|Deltaproteobacteria,2MS22@213462|Syntrophobacterales 28221|Deltaproteobacteria J Telomere recombination - - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC k59_97789_2 1304885.AUEY01000073_gene1474 5.55e-13 68.9 COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,42NTB@68525|delta/epsilon subdivisions,2WKNX@28221|Deltaproteobacteria,2MIZG@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF1015) - - - - - - - - - - - - DUF1015 k59_716251_1 1411123.JQNH01000001_gene2102 1.35e-134 393.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Serine-pyruvate aminotransferase archaeal aspartate aminotransferase pucG - 2.6.1.112,2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830,ko:K00839 ko00230,ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00230,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588,R10908 RC00006,RC00008,RC00018,RC03305 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_1301051_2 42256.RradSPS_0204 3.09e-49 169.0 COG0614@1|root,COG0614@2|Bacteria,2GM6R@201174|Actinobacteria,4CQ1N@84995|Rubrobacteria 84995|Rubrobacteria P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_351237_2 743525.TSC_c00990 5.49e-36 137.0 COG0843@1|root,COG0843@2|Bacteria,1WI0P@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Cytochrome C and Quinol oxidase polypeptide I - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_1450244_1 1380386.JIAW01000010_gene4189 9.29e-66 218.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,235TW@1762|Mycobacteriaceae 201174|Actinobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_515198_1 926550.CLDAP_10170 4.81e-33 132.0 COG3356@1|root,COG3356@2|Bacteria,2G7ZP@200795|Chloroflexi 200795|Chloroflexi S PFAM Neutral alkaline nonlysosomal ceramidase - - - - - - - - - - - - - k59_608653_1 1196323.ALKF01000200_gene2791 8.49e-40 142.0 COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,4H9V0@91061|Bacilli,26SQY@186822|Paenibacillaceae 91061|Bacilli M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB - 5.2.1.8 ko:K01802,ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_608653_2 941449.dsx2_1886 1.52e-07 56.6 COG0457@1|root,COG0457@2|Bacteria,1PDTX@1224|Proteobacteria,42RK5@68525|delta/epsilon subdivisions,2WNZC@28221|Deltaproteobacteria,2M93P@213115|Desulfovibrionales 28221|Deltaproteobacteria D repeat-containing protein - - - - - - - - - - - - SPOR,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_401653_1 1298593.TOL_1845 2.76e-91 286.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1XI2V@135619|Oceanospirillales 135619|Oceanospirillales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) mltD - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_1242950_1 330214.NIDE1862 1.02e-36 125.0 2CC8H@1|root,330SM@2|Bacteria,3J1D6@40117|Nitrospirae 40117|Nitrospirae - - - - - - - - - - - - - - - k59_674101_1 479432.Sros_1485 7.42e-06 47.0 COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria,4EFHI@85012|Streptosporangiales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain fadD19 - 6.2.1.42 ko:K18688 - - - - ko00000,ko01000 - - - AMP-binding,AMP-binding_C k59_674101_2 685727.REQ_15890 1.56e-48 163.0 COG0778@1|root,COG0778@2|Bacteria,2HI8Q@201174|Actinobacteria,4FYH9@85025|Nocardiaceae 201174|Actinobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_1508678_1 439235.Dalk_1834 1.43e-65 210.0 COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,42PJV@68525|delta/epsilon subdivisions,2WKRG@28221|Deltaproteobacteria,2MKNF@213118|Desulfobacterales 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel k59_674107_1 930166.CD58_28870 3.92e-20 87.4 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the UPF0758 family radC GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - ko:K03630 - - - - ko00000 - - - RadC k59_1082734_1 6183.Smp_131050.1 2.38e-05 49.7 COG0664@1|root,KOG1113@2759|Eukaryota,38GS1@33154|Opisthokonta,3BESA@33208|Metazoa,3CWK8@33213|Bilateria 33208|Metazoa T Camp-dependent protein kinase type PRKAR2B GO:0000086,GO:0000166,GO:0000278,GO:0000902,GO:0000904,GO:0001664,GO:0001674,GO:0001932,GO:0001933,GO:0001934,GO:0003008,GO:0003014,GO:0003091,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005813,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0005929,GO:0005952,GO:0006082,GO:0006469,GO:0006629,GO:0006631,GO:0006928,GO:0006935,GO:0006950,GO:0006996,GO:0007049,GO:0007154,GO:0007165,GO:0007275,GO:0007346,GO:0007399,GO:0007409,GO:0007411,GO:0007596,GO:0007599,GO:0007610,GO:0007611,GO:0007612,GO:0007622,GO:0007623,GO:0007626,GO:0008150,GO:0008152,GO:0008603,GO:0009410,GO:0009605,GO:0009611,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009892,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010389,GO:0010562,GO:0010563,GO:0010564,GO:0010604,GO:0010605,GO:0010720,GO:0014070,GO:0015630,GO:0016020,GO:0016043,GO:0017076,GO:0019207,GO:0019210,GO:0019220,GO:0019222,GO:0019752,GO:0019866,GO:0019887,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0022008,GO:0022402,GO:0022406,GO:0022607,GO:0023052,GO:0030030,GO:0030031,GO:0030104,GO:0030154,GO:0030182,GO:0030234,GO:0030291,GO:0030315,GO:0030425,GO:0030534,GO:0030551,GO:0030552,GO:0030554,GO:0031090,GO:0031175,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0031401,GO:0031588,GO:0031625,GO:0031690,GO:0031698,GO:0031966,GO:0031967,GO:0031975,GO:0032147,GO:0032268,GO:0032269,GO:0032270,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032870,GO:0032989,GO:0032990,GO:0032991,GO:0033673,GO:0033674,GO:0033762,GO:0034199,GO:0034236,GO:0035556,GO:0036094,GO:0036477,GO:0040011,GO:0042060,GO:0042220,GO:0042221,GO:0042325,GO:0042326,GO:0042327,GO:0042330,GO:0042383,GO:0042493,GO:0042585,GO:0042592,GO:0042802,GO:0042803,GO:0042995,GO:0043005,GO:0043025,GO:0043073,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043197,GO:0043198,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043279,GO:0043434,GO:0043436,GO:0043549,GO:0043900,GO:0043902,GO:0043933,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044297,GO:0044309,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044456,GO:0044459,GO:0044463,GO:0044464,GO:0044770,GO:0044772,GO:0044782,GO:0044839,GO:0044853,GO:0045121,GO:0045202,GO:0045471,GO:0045475,GO:0045595,GO:0045597,GO:0045787,GO:0045859,GO:0045860,GO:0045936,GO:0045937,GO:0046677,GO:0046983,GO:0048148,GO:0048149,GO:0048468,GO:0048471,GO:0048511,GO:0048512,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0048871,GO:0048878,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050817,GO:0050877,GO:0050878,GO:0050890,GO:0050891,GO:0050896,GO:0051018,GO:0051094,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051239,GO:0051240,GO:0051246,GO:0051247,GO:0051248,GO:0051259,GO:0051291,GO:0051338,GO:0051347,GO:0051348,GO:0051445,GO:0051446,GO:0051640,GO:0051641,GO:0051716,GO:0051726,GO:0060255,GO:0060271,GO:0060281,GO:0060282,GO:0060284,GO:0060359,GO:0061564,GO:0061695,GO:0065003,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0070925,GO:0071310,GO:0071375,GO:0071377,GO:0071417,GO:0071495,GO:0071704,GO:0071840,GO:0071900,GO:0071901,GO:0071944,GO:0072347,GO:0080090,GO:0090068,GO:0097159,GO:0097305,GO:0097332,GO:0097338,GO:0097367,GO:0097447,GO:0097458,GO:0097485,GO:0097546,GO:0097711,GO:0098589,GO:0098590,GO:0098772,GO:0098794,GO:0098805,GO:0098857,GO:0120025,GO:0120031,GO:0120036,GO:0120038,GO:0120039,GO:0140056,GO:1900193,GO:1900195,GO:1901265,GO:1901363,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901987,GO:1901990,GO:1902494,GO:1902749,GO:1902911,GO:1903047,GO:1903429,GO:1903431,GO:1903538,GO:1904146,GO:1905879,GO:1905881,GO:1990234,GO:2000241,GO:2000243,GO:2000479,GO:2000480 - ko:K04739 ko04910,map04910 - - - ko00000,ko00001 - - - RIIa,cNMP_binding k59_1082734_2 1279017.AQYJ01000027_gene1807 1.51e-31 122.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,46440@72275|Alteromonadaceae 1236|Gammaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_1661966_1 698769.JFBD01000053_gene515 1.83e-60 200.0 COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,4HBCU@91061|Bacilli,4C4Q6@84406|Virgibacillus 91061|Bacilli I Acyl transferase domain fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_1450269_1 1121033.AUCF01000006_gene4122 6.71e-15 72.0 COG1959@1|root,COG1959@2|Bacteria,1N0E2@1224|Proteobacteria,2U9Z9@28211|Alphaproteobacteria,2JT9W@204441|Rhodospirillales 204441|Rhodospirillales K Transcriptional regulator - - - - - - - - - - - - Rrf2 k59_1450269_2 297246.lpp0652 6.78e-55 185.0 COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,1RQ65@1236|Gammaproteobacteria,1JCSM@118969|Legionellales 118969|Legionellales O Uncharacterized protein family (UPF0051) sufB - - ko:K09014 - - - - ko00000 - - - UPF0051 k59_870869_1 395493.BegalDRAFT_0465 1.96e-36 139.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,460IE@72273|Thiotrichales 72273|Thiotrichales U AAA domain - - - - - - - - - - - - AAA_22 k59_716299_1 436308.Nmar_0333 2.26e-87 284.0 arCOG08778@1|root,arCOG08778@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1082753_1 471853.Bcav_3576 1.11e-77 261.0 COG3459@1|root,COG3459@2|Bacteria 2|Bacteria G carbohydrate binding cbpA - 2.4.1.333 ko:K21298 - - - - ko00000,ko01000 - GH94 - Glyco_hydro_36,Glyco_transf_36 k59_143748_2 1168065.DOK_14704 2.95e-108 317.0 COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,1RRMA@1236|Gammaproteobacteria,1J4ZM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Transglutaminase/protease-like homologues - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_1662001_1 1307759.JOMJ01000003_gene1523 2.05e-82 252.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WM7T@28221|Deltaproteobacteria,2M8AB@213115|Desulfovibrionales 28221|Deltaproteobacteria V pfam abc - - - ko:K01990,ko:K09695 ko02010,map02010 M00252,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.102 - - ABC_tran,DUF4162 k59_1450281_1 1288494.EBAPG3_960 2.59e-56 178.0 COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,2WAWH@28216|Betaproteobacteria,3734U@32003|Nitrosomonadales 28216|Betaproteobacteria F Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF k59_1301137_2 1333998.M2A_2493 2.68e-61 199.0 COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,4BTBG@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_974828_1 395493.BegalDRAFT_1138 3.1e-29 120.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,45ZXV@72273|Thiotrichales 72273|Thiotrichales U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_716316_1 1192034.CAP_2352 4.75e-73 236.0 COG3325@1|root,COG3325@2|Bacteria,1MWAR@1224|Proteobacteria,437VC@68525|delta/epsilon subdivisions,2WYPH@28221|Deltaproteobacteria,2YUAF@29|Myxococcales 28221|Deltaproteobacteria G Belongs to the glycosyl hydrolase 18 family - - 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - GH18 - Glyco_hydro_18 k59_926215_1 323848.Nmul_A0212 6.15e-79 248.0 COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,2VKQB@28216|Betaproteobacteria,3720Y@32003|Nitrosomonadales 28216|Betaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_926215_2 87626.PTD2_14822 1.65e-25 98.2 COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,2Q2GT@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH GO:0001505,GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0017144,GO:0019464,GO:0019752,GO:0031405,GO:0031406,GO:0033293,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901681 - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - iE2348C_1286.E2348C_3156,iPC815.YPO0906 GCV_H k59_1541504_1 1125863.JAFN01000001_gene1438 2.89e-101 326.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_351300_2 187272.Mlg_1238 1.56e-92 279.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1WW2U@135613|Chromatiales 135613|Chromatiales I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_299177_1 1027273.GZ77_18860 5.28e-11 62.8 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria,1XJJW@135619|Oceanospirillales 135619|Oceanospirillales J Ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_299177_2 1121033.AUCF01000003_gene3500 9.15e-11 61.2 COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,2TVNY@28211|Alphaproteobacteria,2JS9Y@204441|Rhodospirillales 204441|Rhodospirillales S S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans k59_351312_1 530564.Psta_2657 2.85e-36 140.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,2IY13@203682|Planctomycetes 203682|Planctomycetes E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_1301167_1 75379.Tint_2671 9.48e-26 107.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,1KKAT@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Involved in the biosynthesis of porphyrin-containing compound hemN2 - - - - - - - - - - - HemN_C,Radical_SAM k59_674199_1 472759.Nhal_1284 8.39e-46 158.0 COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,1RMHK@1236|Gammaproteobacteria,1X1NE@135613|Chromatiales 135613|Chromatiales L transposase IS4 - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_1541526_1 1205680.CAKO01000037_gene1210 2.48e-112 337.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JR7C@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the aldehyde dehydrogenase family betB - - - - - - - - - - - Aldedh k59_1662047_1 436308.Nmar_1312 2.66e-94 288.0 COG0334@1|root,arCOG01352@2157|Archaea,41S7T@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_716346_1 685727.REQ_10050 1.63e-70 226.0 COG1902@1|root,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,4FUWR@85025|Nocardiaceae 201174|Actinobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - 1.8.1.20 ko:K22347 - - - - ko00000,ko01000 - - - Oxidored_FMN k59_516532_2 1123229.AUBC01000033_gene3588 4.27e-14 72.4 COG0583@1|root,COG0583@2|Bacteria,1PX1B@1224|Proteobacteria,2TUE7@28211|Alphaproteobacteria,3JXD9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_402569_1 1254432.SCE1572_48085 5.71e-108 329.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria 1224|Proteobacteria H biosynthesis protein E pqqE GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663 - ko:K06139 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_558099_1 370438.PTH_0857 2.74e-11 70.9 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,26014@186807|Peptococcaceae 186801|Clostridia S DNA internalization-related competence protein ComEC Rec2 comEC - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_402575_1 1205680.CAKO01000030_gene4915 1.26e-66 214.0 COG1703@1|root,COG1703@2|Bacteria,1R44P@1224|Proteobacteria,2TW2E@28211|Alphaproteobacteria,2JR6W@204441|Rhodospirillales 204441|Rhodospirillales E periplasmic protein kinase ArgK and related GTPases of G3E family - - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k59_927148_1 1189612.A33Q_3092 1.72e-25 100.0 COG1607@1|root,COG1607@2|Bacteria,4NMK1@976|Bacteroidetes,47N9Z@768503|Cytophagia 976|Bacteroidetes I PFAM thioesterase superfamily - - - - - - - - - - - - 4HBT k59_927148_2 929703.KE386491_gene2186 1.16e-26 108.0 COG0006@1|root,COG0006@2|Bacteria,4NF0F@976|Bacteroidetes,47JWC@768503|Cytophagia 976|Bacteroidetes E Metallopeptidase family M24 - - - - - - - - - - - - Peptidase_M24 k59_1542409_1 330214.NIDE0681 3.94e-113 338.0 COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae 40117|Nitrospirae M Evidence 2a Function of homologous gene experimentally demonstrated in an other organism - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_717226_1 546273.VEIDISOL_00438 8.78e-114 337.0 COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,4H22P@909932|Negativicutes 909932|Negativicutes J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_1028160_1 330214.NIDE0899 6.72e-95 285.0 COG1290@1|root,COG1290@2|Bacteria,3J0Q6@40117|Nitrospirae 40117|Nitrospirae C Cytochrome b/b6/petB - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_832605_1 1089552.KI911559_gene2017 2.75e-36 124.0 COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,2JT7W@204441|Rhodospirillales 204441|Rhodospirillales L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_832605_2 311424.DhcVS_776 6.66e-132 380.0 COG2801@1|root,COG2801@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia 301297|Dehalococcoidia L PFAM Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_1451007_1 316067.Geob_1130 7.18e-51 171.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,42M0X@68525|delta/epsilon subdivisions,2WK4D@28221|Deltaproteobacteria,43SVU@69541|Desulfuromonadales 28221|Deltaproteobacteria EM Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_245191_1 335283.Neut_1785 2.17e-35 129.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,371U7@32003|Nitrosomonadales 28216|Betaproteobacteria K RNA polymerase sigma factor rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_352227_1 243233.MCA1532 2.88e-25 100.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,1XEBH@135618|Methylococcales 135618|Methylococcales J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_516585_1 574966.KB898647_gene2502 3.91e-10 60.1 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1XHPF@135619|Oceanospirillales 135619|Oceanospirillales F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_1392505_1 215803.DB30_5776 6.51e-54 176.0 COG1595@1|root,COG1595@2|Bacteria,1RBM4@1224|Proteobacteria,42S7N@68525|delta/epsilon subdivisions,2X3DW@28221|Deltaproteobacteria,2YUWD@29|Myxococcales 28221|Deltaproteobacteria K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_871773_1 379066.GAU_3713 2.46e-13 67.4 COG2944@1|root,COG2944@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - ko:K07726 - - - - ko00000,ko03000 - - - Fer4,HTH_3,HTH_31 k59_832626_2 1089547.KB913013_gene1144 0.000636 45.1 COG2373@1|root,COG4932@1|root,COG2373@2|Bacteria,COG4932@2|Bacteria,4PKCH@976|Bacteroidetes,47YME@768503|Cytophagia 976|Bacteroidetes M SdrD B-like domain - - - - - - - - - - - - CHU_C,DUF11,SdrD_B k59_402606_1 525146.Ddes_1579 4.18e-15 76.6 COG3969@1|root,COG3969@2|Bacteria,1NBDM@1224|Proteobacteria,42YI7@68525|delta/epsilon subdivisions,2WTVR@28221|Deltaproteobacteria,2MAX0@213115|Desulfovibrionales 28221|Deltaproteobacteria S Domain of unknown function (DUF3440) - - - - - - - - - - - - DUF3440,PAPS_reduct k59_832632_1 765914.ThisiDRAFT_2647 9.18e-36 132.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1WWXY@135613|Chromatiales 135613|Chromatiales S Permease YjgP YjgQ - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_352240_1 481448.Minf_2159 1.57e-65 208.0 COG0500@1|root,COG2226@2|Bacteria,46X32@74201|Verrucomicrobia,37H6J@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 k59_1083704_1 1229909.NSED_04250 6.13e-107 325.0 COG0168@1|root,COG0517@1|root,arCOG00606@2157|Archaea,arCOG04145@2157|Archaea,41SZ8@651137|Thaumarchaeota 651137|Thaumarchaeota P CBS domain - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - CBS,TrkH k59_1302493_1 268746.Q58MP3_BPPRM 2.93e-33 132.0 4QBUC@10239|Viruses,4QQGQ@28883|Caudovirales,4QHY3@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1400136_1 220664.PFL_5407 1.61e-37 141.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1YN71@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria JKL Belongs to the DEAD box helicase family rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_152585_2 338969.Rfer_3895 3.96e-100 315.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria 28216|Betaproteobacteria G alpha-glucan phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_1400139_2 1123355.JHYO01000003_gene2817 4.97e-64 203.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2TSWH@28211|Alphaproteobacteria,36XJR@31993|Methylocystaceae 28211|Alphaproteobacteria D Cellulose biosynthesis protein BcsQ parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1458689_1 1367847.JCM7686_1808 8.25e-75 242.0 COG1167@1|root,COG1167@2|Bacteria,1MVGT@1224|Proteobacteria,2TRK7@28211|Alphaproteobacteria,2PY8U@265|Paracoccus 28211|Alphaproteobacteria K helix_turn_helix gluconate operon transcriptional repressor - - - ko:K00375 - - - - ko00000,ko03000 - - - Aminotran_1_2,GntR k59_725007_1 1123247.AUIJ01000007_gene2892 2.88e-05 45.4 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TTRD@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase MA20_06720 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_725007_2 1429916.X566_16120 4.13e-40 144.0 COG1960@1|root,COG1960@2|Bacteria,1N05C@1224|Proteobacteria,2TT9T@28211|Alphaproteobacteria,3JTG7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I acyl-CoA dehydrogenase MA20_06725 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_360393_1 211114.JOEF01000004_gene6525 2.85e-104 316.0 COG0160@1|root,COG0160@2|Bacteria,2GKVH@201174|Actinobacteria,4DZMQ@85010|Pseudonocardiales 201174|Actinobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.19 ko:K00823 ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1551145_1 1278078.G419_22009 3.05e-27 114.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FV7A@85025|Nocardiaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_252994_1 1242864.D187_003545 4.63e-05 52.4 COG4412@1|root,COG4932@1|root,COG4412@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,438GF@68525|delta/epsilon subdivisions,2X3RA@28221|Deltaproteobacteria,2YWWZ@29|Myxococcales 28221|Deltaproteobacteria M Bacterial Ig-like domain (group 1) - - - - - - - - - - - - Big_1,LTD k59_360413_1 330214.NIDE2456 9.53e-118 342.0 COG0061@1|root,COG0061@2|Bacteria,3J0HS@40117|Nitrospirae 40117|Nitrospirae H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_1145129_1 357804.Ping_3710 3.28e-50 167.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,2QJ1Q@267894|Psychromonadaceae 1236|Gammaproteobacteria V ATPases associated with a variety of cellular activities - - - ko:K02003,ko:K09810 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 - - ABC_tran k59_1145129_2 62928.azo0833 7.66e-09 57.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2VIIH@28216|Betaproteobacteria,2KU75@206389|Rhodocyclales 206389|Rhodocyclales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1251785_1 1206741.BAFX01000074_gene4283 8.86e-51 177.0 COG1012@1|root,COG1012@2|Bacteria,2GJ95@201174|Actinobacteria,4G5V6@85025|Nocardiaceae 201174|Actinobacteria C Aldehyde dehydrogenase family - - 1.2.99.10 ko:K22445 - - - - ko00000,ko01000 - - - Aldedh k59_1344723_1 1203605.HMPREF1531_01151 2.45e-52 182.0 COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,4DU0U@85009|Propionibacteriales 201174|Actinobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster preT - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3 k59_565890_1 754477.Q7C_2656 1.29e-43 151.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria,4603D@72273|Thiotrichales 72273|Thiotrichales I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_253005_1 1226994.AMZB01000122_gene2690 2.05e-58 205.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1YEZ2@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Signal transducing histidine kinase, homodimeric domain chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1035941_1 1536773.R70331_16735 2.07e-57 186.0 COG3576@1|root,COG3576@2|Bacteria,1UZ02@1239|Firmicutes,4HEN8@91061|Bacilli,26R91@186822|Paenibacillaceae 91061|Bacilli S Pyridoxamine 5'-phosphate oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_152632_1 396588.Tgr7_3044 1.33e-07 52.4 COG0515@1|root,COG0515@2|Bacteria,1NUIB@1224|Proteobacteria 1224|Proteobacteria KLT Protein tyrosine kinase - - - - - - - - - - - - Pkinase k59_152632_2 595460.RRSWK_04882 5.52e-70 224.0 COG0631@1|root,COG0631@2|Bacteria 2|Bacteria T protein serine/threonine phosphatase activity - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_152632_3 264198.Reut_B3772 9.03e-41 147.0 COG0280@1|root,COG0280@2|Bacteria,1QTS5@1224|Proteobacteria,2VK9K@28216|Betaproteobacteria,1K4RA@119060|Burkholderiaceae 28216|Betaproteobacteria C phosphate acetyltransferase pta - 2.3.1.8 ko:K00625,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - PTA_PTB k59_152634_1 187272.Mlg_0334 6.28e-56 186.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,1WW2P@135613|Chromatiales 135613|Chromatiales D Reduces the stability of FtsZ polymers in the presence of ATP zapE - - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_1253184_1 1037409.BJ6T_02850 4.48e-19 91.7 COG1033@1|root,COG1033@2|Bacteria,1QWS6@1224|Proteobacteria,2TX3E@28211|Alphaproteobacteria,3K6YV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S TIGRFAM hopanoid biosynthesis associated RND transporter like protein HpnN - - - ko:K07003 - - - - ko00000 - - - MMPL k59_775303_1 765911.Thivi_4487 4.75e-73 245.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1WW7V@135613|Chromatiales 135613|Chromatiales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_726219_1 1469245.JFBG01000096_gene1302 1.2e-30 114.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,1RPK3@1236|Gammaproteobacteria,1WWEP@135613|Chromatiales 135613|Chromatiales J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_726219_2 264198.Reut_A3037 8.16e-83 257.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2VJ1W@28216|Betaproteobacteria,1K3VB@119060|Burkholderiaceae 28216|Betaproteobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_467575_1 644282.Deba_0743 7.2e-15 72.4 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,42NAA@68525|delta/epsilon subdivisions,2WNMN@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_467575_2 760568.Desku_2556 9.64e-37 133.0 COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,260D7@186807|Peptococcaceae 186801|Clostridia H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_880733_1 247633.GP2143_16536 4.76e-117 348.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1J4KM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_1190017_1 95619.PM1_0218360 7.52e-96 288.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008840,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_2492,iJN746.PP_1237,iYL1228.KPN_02812 DHDPS k59_1253197_1 84531.JMTZ01000088_gene1481 1.95e-22 96.3 COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,1RRMM@1236|Gammaproteobacteria,1X2YX@135614|Xanthomonadales 135614|Xanthomonadales E phospho-2-dehydro-3-deoxyheptonate aldolase dhs1 - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_2 k59_1253197_2 1469245.JFBG01000044_gene1862 5.04e-49 163.0 COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,1S6WD@1236|Gammaproteobacteria,1WZSH@135613|Chromatiales 135613|Chromatiales C Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein dsbB - - ko:K03611 - - - - ko00000,ko03110 5.A.2.1 - - DsbB k59_1146889_1 1504672.669784345 2.17e-33 122.0 28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria,2VRVF@28216|Betaproteobacteria,4AE77@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of unknown function (DUF4126) - - - - - - - - - - - - DUF4126 k59_1460209_1 1229909.NSED_07270 4.87e-129 377.0 COG0334@1|root,arCOG01352@2157|Archaea,41S7T@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_198191_2 243231.GSU0983 1.95e-24 101.0 COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,42PYY@68525|delta/epsilon subdivisions,2WJID@28221|Deltaproteobacteria,43VNU@69541|Desulfuromonadales 28221|Deltaproteobacteria S Phage late control gene D protein (GPD) - - - - - - - - - - - - Phage_GPD k59_880745_2 445686.E3SLA1_9CAUD 4.45e-91 290.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage 10239|Viruses S DNA polymerase family B - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004527,GO:0004540,GO:0005575,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016032,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018130,GO:0018995,GO:0019058,GO:0019079,GO:0019438,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0039686,GO:0039693,GO:0042025,GO:0042221,GO:0043170,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044403,GO:0044419,GO:0046483,GO:0050896,GO:0051704,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902074 - - - - - - - - - - - k59_1190028_1 1131269.AQVV01000025_gene2337 6.61e-58 207.0 COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria 2|Bacteria D von Willebrand factor, type A MA20_44660 - - - - - - - - - - - GATase1_like k59_1552674_1 68219.JNXI01000008_gene3042 2.91e-33 123.0 COG0025@1|root,COG2343@1|root,COG0025@2|Bacteria,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria 201174|Actinobacteria IQ protein conserved in bacteria - - - - - - - - - - - - NTP_transf_9 k59_1552674_2 566466.NOR53_147 1.1e-13 73.6 COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,1RYAY@1236|Gammaproteobacteria,1J7UG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S ABC1 family - - - - - - - - - - - - ABC1 k59_1146910_1 1123401.JHYQ01000026_gene3246 1.27e-08 55.5 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MX4H@1224|Proteobacteria,1RRJV@1236|Gammaproteobacteria,461X2@72273|Thiotrichales 72273|Thiotrichales P Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1146910_2 713586.KB900536_gene232 1.99e-166 484.0 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1WXYV@135613|Chromatiales 135613|Chromatiales M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella mltF GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_1093629_1 1429916.X566_16490 7.28e-76 235.0 COG0583@1|root,COG0583@2|Bacteria,1N4P5@1224|Proteobacteria,2TQYX@28211|Alphaproteobacteria,3JS6Y@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K LysR family QU41_25640 - - - - - - - - - - - HTH_1,LysR_substrate k59_413156_1 279010.BL03976 6.48e-37 141.0 COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,4HBF1@91061|Bacilli,1ZQEV@1386|Bacillus 91061|Bacilli C malic enzyme malS GO:0003674,GO:0003824,GO:0004470,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006090,GO:0006108,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016615,GO:0019752,GO:0032787,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071704 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic k59_254248_1 436308.Nmar_1783 6.41e-50 165.0 COG2112@1|root,arCOG01182@2157|Archaea,41SJV@651137|Thaumarchaeota 651137|Thaumarchaeota T Ser thr protein kinase - - - ko:K07176 - - - - ko00000 - - - RIO1 k59_254248_2 436308.Nmar_1782 4.3e-31 120.0 COG1746@1|root,arCOG04249@2157|Archaea,41S76@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate cca - 2.7.7.72 ko:K07558 - - R09382,R09383,R09384,R09386 RC00078 ko00000,ko01000,ko03016 - - - NTP_transf_2,tRNA_NucTransf2 k59_1552700_1 1380394.JADL01000002_gene1100 4.55e-99 293.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,2JPE4@204441|Rhodospirillales 204441|Rhodospirillales E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_1460255_1 648996.Theam_0269 1.46e-10 61.2 COG0094@1|root,COG0094@2|Bacteria,2G3N4@200783|Aquificae 200783|Aquificae J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_1460255_2 330214.NIDE1322 6.6e-51 163.0 COG0198@1|root,COG0198@2|Bacteria,3J0VK@40117|Nitrospirae 40117|Nitrospirae J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_937210_1 1415754.JQMK01000006_gene3795 1.96e-23 108.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,465V0@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat k59_361884_1 391625.PPSIR1_40710 1.54e-56 189.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria,2Z21X@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the ferrous insertion into protoporphyrin IX hemH GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_310087_1 574966.KB898648_gene806 1.03e-20 88.2 COG1335@1|root,COG1335@2|Bacteria,1MZP9@1224|Proteobacteria,1SHQ7@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_983941_1 546271.Selsp_1910 4.26e-18 82.8 COG0589@1|root,COG0589@2|Bacteria,1U42B@1239|Firmicutes,4H7IH@909932|Negativicutes 909932|Negativicutes T Universal stress protein family - - - - - - - - - - - - Usp k59_254273_1 96561.Dole_3153 4.34e-05 44.7 COG0582@1|root,COG0582@2|Bacteria 2|Bacteria L DNA integration - - - - - - - - - - - - Phage_integrase k59_880808_1 1122134.KB893650_gene310 3.17e-14 70.1 COG0625@1|root,COG0625@2|Bacteria,1REDI@1224|Proteobacteria,1S13N@1236|Gammaproteobacteria,1XK36@135619|Oceanospirillales 135619|Oceanospirillales O Belongs to the GST superfamily - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N,GST_N_3 k59_1552748_1 861299.J421_2862 1.05e-199 564.0 COG0499@1|root,COG0499@2|Bacteria,1ZTEF@142182|Gemmatimonadetes 142182|Gemmatimonadetes H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_310117_1 243233.MCA0122 8.49e-64 206.0 COG2378@1|root,COG2378@2|Bacteria,1P2ZE@1224|Proteobacteria,1RYHJ@1236|Gammaproteobacteria,1XEZT@135618|Methylococcales 135618|Methylococcales K WYL domain - - - - - - - - - - - - WYL k59_254291_1 1191523.MROS_2364 1.48e-38 135.0 COG0605@1|root,COG0605@2|Bacteria 2|Bacteria C Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodA - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_880823_1 1288826.MSNKSG1_15452 1.6e-99 314.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,469S2@72275|Alteromonadaceae 1236|Gammaproteobacteria C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region fdhF GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0015942,GO:0015944,GO:0016491,GO:0016651,GO:0016999,GO:0017144,GO:0019752,GO:0030151,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704 1.17.1.9,1.17.99.7 ko:K00123,ko:K22015 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - iECBD_1354.ECBD_3953 Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_467700_1 246197.MXAN_1356 2.97e-67 223.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,42NA6@68525|delta/epsilon subdivisions,2WIMU@28221|Deltaproteobacteria,2YU9T@29|Myxococcales 28221|Deltaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_1253310_1 269799.Gmet_2580 1.92e-78 261.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_413247_1 1463936.JOJI01000011_gene1099 6.93e-36 135.0 COG0183@1|root,COG0183@2|Bacteria,2GJ0W@201174|Actinobacteria 201174|Actinobacteria I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation ltp3 - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - - k59_1608886_1 656024.FsymDg_4067 4.33e-06 54.7 COG5002@1|root,COG5002@2|Bacteria,2GJY7@201174|Actinobacteria,4EREU@85013|Frankiales 201174|Actinobacteria T Histidine kinase senX3 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564 2.7.13.3 ko:K07768 ko02020,map02020 M00443 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_567239_1 1122164.JHWF01000010_gene2380 2.31e-48 169.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1JCMD@118969|Legionellales 118969|Legionellales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_254322_1 1121403.AUCV01000001_gene710 5.97e-07 51.2 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,42MTU@68525|delta/epsilon subdivisions,2WKN8@28221|Deltaproteobacteria,2MPNF@213118|Desulfobacterales 28221|Deltaproteobacteria C NQR2, RnfD, RnfE family nqrB - 1.6.5.8 ko:K00347 - - - - ko00000,ko01000 - - - NQR2_RnfD_RnfE k59_984022_2 330214.NIDE4161 5.26e-57 179.0 COG2210@1|root,COG2210@2|Bacteria 2|Bacteria P Belongs to the sulfur carrier protein TusA family - - - - - - - - - - - - DrsE_2 k59_1460347_1 574087.Acear_1431 4.25e-32 125.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,3WAED@53433|Halanaerobiales 186801|Clostridia H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_310165_1 330214.NIDE0539 2.14e-37 140.0 COG1674@1|root,COG1674@2|Bacteria,3J0BQ@40117|Nitrospirae 40117|Nitrospirae D Ftsk_gamma ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_310165_2 330214.NIDE0540 3.88e-26 103.0 COG2834@1|root,COG2834@2|Bacteria,3J1C6@40117|Nitrospirae 40117|Nitrospirae M Outer membrane lipoprotein carrier protein LolA - - - ko:K03634 - - - - ko00000 - - - LolA k59_254330_2 697282.Mettu_3861 1.48e-39 144.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1XEMS@135618|Methylococcales 135618|Methylococcales F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_54225_2 439235.Dalk_3185 2e-84 266.0 COG0204@1|root,COG0204@2|Bacteria,1RF5A@1224|Proteobacteria,4300N@68525|delta/epsilon subdivisions,2WVIK@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase k59_315048_1 396588.Tgr7_2473 2.66e-62 203.0 COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,1RR44@1236|Gammaproteobacteria,1WVVH@135613|Chromatiales 135613|Chromatiales S Methyltransferase - - 2.1.1.44 ko:K18911 ko00340,map00340 - R01169 RC00003,RC02308 ko00000,ko00001,ko01000 - - - Methyltransf_33 k59_1307230_1 981336.F944_01744 2.18e-13 72.4 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,3NMBB@468|Moraxellaceae 1236|Gammaproteobacteria V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_419472_1 713586.KB900536_gene873 1.98e-40 147.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,1RPJH@1236|Gammaproteobacteria,1WWU7@135613|Chromatiales 135613|Chromatiales L PFAM Transposase IS200 like - - - - - - - - - - - - Bac_DnaA_C,Y1_Tnp k59_993729_1 1458275.AZ34_16350 2.62e-12 72.4 COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,2VMI9@28216|Betaproteobacteria,4ACCB@80864|Comamonadaceae 28216|Betaproteobacteria P Tonb-dependent hemoglobin transferrin lactoferrin family receptor bhuR - - ko:K16087 - - - - ko00000,ko02000 1.B.14.2 - - Plug,STN,TonB_dep_Rec k59_1255522_1 404589.Anae109_3458 1.27e-65 218.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,42NMY@68525|delta/epsilon subdivisions,2WJ8S@28221|Deltaproteobacteria,2YU74@29|Myxococcales 28221|Deltaproteobacteria M Mur ligase family, catalytic domain mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_941626_1 1248917.ANFX01000040_gene801 3.53e-75 234.0 COG0500@1|root,COG2226@2|Bacteria,1R42G@1224|Proteobacteria,2U1CY@28211|Alphaproteobacteria,2K893@204457|Sphingomonadales 204457|Sphingomonadales Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k59_1620983_1 1198232.CYCME_0391 2.44e-86 258.0 COG2259@1|root,COG2259@2|Bacteria,1RBZP@1224|Proteobacteria,1S28E@1236|Gammaproteobacteria,460P8@72273|Thiotrichales 72273|Thiotrichales S DoxX - - - - - - - - - - - - DoxX k59_576051_1 694431.DESACE_09600 9.94e-80 249.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2M6PH@213113|Desulfurellales 28221|Deltaproteobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_682046_1 1048339.KB913029_gene3014 9.35e-24 103.0 COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,4EU00@85013|Frankiales 201174|Actinobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_420322_1 1523503.JPMY01000041_gene455 0.000864 40.4 COG0346@1|root,COG0346@2|Bacteria,1RH4C@1224|Proteobacteria,1SQ7D@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_420322_2 240016.ABIZ01000001_gene2814 1.68e-72 219.0 COG3795@1|root,COG3795@2|Bacteria,46V6E@74201|Verrucomicrobia,2IVM1@203494|Verrucomicrobiae 203494|Verrucomicrobiae S YCII-related domain - - - - - - - - - - - - YCII k59_1516443_1 631454.N177_0823 1.02e-64 212.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,1JPPV@119043|Rhodobiaceae 28211|Alphaproteobacteria Q Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_733768_1 420662.Mpe_A1216 5.9e-99 300.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,2VPGP@28216|Betaproteobacteria,1KM0J@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_733768_2 1395571.TMS3_0121235 3.94e-53 170.0 2DVMI@1|root,33WD7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_106568_1 187272.Mlg_2779 4.16e-71 244.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1WW36@135613|Chromatiales 135613|Chromatiales E PFAM NAD-glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_1204398_1 1137799.GZ78_03045 1.25e-31 122.0 COG0318@1|root,COG0318@2|Bacteria,1MVJ1@1224|Proteobacteria,1RS4E@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1204398_2 1206731.BAGB01000025_gene3156 3.68e-50 175.0 COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4FYUQ@85025|Nocardiaceae 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_368223_1 1380390.JIAT01000001_gene5055 2.31e-50 183.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4CRFS@84995|Rubrobacteria 84995|Rubrobacteria C PFAM L-carnitine dehydratase bile acid-inducible protein F - - 2.8.3.16,2.8.3.20 ko:K07749,ko:K18313 - - R10640,R10641 RC00014 ko00000,ko01000 - - - CoA_transf_3 k59_472164_2 933262.AXAM01000046_gene129 1.35e-52 177.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,2MHVQ@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_1256557_1 1286093.C266_06334 7.67e-107 314.0 COG4525@1|root,COG4525@2|Bacteria,1QTUA@1224|Proteobacteria,2VIKA@28216|Betaproteobacteria,1K2BN@119060|Burkholderiaceae 28216|Betaproteobacteria P Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system tauB - 3.6.3.36 ko:K10831 ko00920,ko02010,map00920,map02010 M00435 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.17.1,3.A.1.17.4 - - ABC_tran k59_1599_1 767434.Fraau_1395 2.1e-56 185.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria,1X367@135614|Xanthomonadales 135614|Xanthomonadales I malonyl CoA-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_1599_2 90814.KL370891_gene764 2.6e-12 65.5 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,45ZQP@72273|Thiotrichales 72273|Thiotrichales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_524791_1 1469245.JFBG01000001_gene531 1.49e-60 198.0 COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,1SBTI@1236|Gammaproteobacteria 1236|Gammaproteobacteria T universal stress protein - - - - - - - - - - - - Usp k59_1412498_1 330214.NIDE0969 2.07e-150 424.0 COG1014@1|root,COG1014@2|Bacteria,3J0Y6@40117|Nitrospirae 40117|Nitrospirae C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR k59_1047183_2 583345.Mmol_1597 3.02e-35 127.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2VJ4G@28216|Betaproteobacteria,2KKQS@206350|Nitrosomonadales 206350|Nitrosomonadales C Belongs to the complex I subunit 6 family - - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_55265_1 1163617.SCD_n02433 4.17e-100 310.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2VJDX@28216|Betaproteobacteria 28216|Betaproteobacteria G trehalohydrolase treZ - 3.2.1.141 ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3459 k59_890607_1 1122604.JONR01000040_gene4032 2.34e-12 64.7 COG0426@1|root,COG0426@2|Bacteria,1N4CQ@1224|Proteobacteria,1SC4U@1236|Gammaproteobacteria,1XDEF@135614|Xanthomonadales 135614|Xanthomonadales C NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red k59_994581_1 1395571.TMS3_0123455 1.78e-87 269.0 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Lytic murein transglycosylase mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_368242_1 1095769.CAHF01000005_gene1570 2.16e-29 116.0 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VMBB@28216|Betaproteobacteria,476ER@75682|Oxalobacteraceae 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_786516_1 29760.VIT_08s0007g07400.t01 3.87e-40 148.0 COG0334@1|root,KOG2250@2759|Eukaryota,37Q3I@33090|Viridiplantae,3G8ZE@35493|Streptophyta 35493|Streptophyta E Belongs to the Glu Leu Phe Val dehydrogenases family GDH1 GO:0000166,GO:0003674,GO:0003824,GO:0004353,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006807,GO:0006950,GO:0006970,GO:0006995,GO:0007154,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009267,GO:0009314,GO:0009416,GO:0009605,GO:0009628,GO:0009642,GO:0009646,GO:0009651,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0016491,GO:0016638,GO:0016639,GO:0017076,GO:0019222,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0035639,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043562,GO:0044424,GO:0044444,GO:0044464,GO:0046686,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0050897,GO:0051171,GO:0051716,GO:0055114,GO:0065007,GO:0071496,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901698 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_838262_1 519989.ECTPHS_01494 5.66e-72 226.0 COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,1RMKF@1236|Gammaproteobacteria,1WWD5@135613|Chromatiales 135613|Chromatiales E Belongs to the peptidase S33 family - - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_682097_1 883078.HMPREF9695_04109 1.55e-77 242.0 COG1024@1|root,COG1024@2|Bacteria,1MWF6@1224|Proteobacteria,2TTQ1@28211|Alphaproteobacteria,3JT0H@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase MA20_19270 - - - - - - - - - - - ECH_1 k59_55273_1 644282.Deba_0413 4.17e-69 233.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria 28221|Deltaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_263703_1 1469245.JFBG01000072_gene78 6.51e-92 295.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_994589_1 378806.STAUR_4537 9.5e-92 283.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P6D@68525|delta/epsilon subdivisions,2WM1P@28221|Deltaproteobacteria,2YUD4@29|Myxococcales 28221|Deltaproteobacteria T DNA-binding response regulator - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1099543_1 177437.HRM2_22640 1.54e-13 77.4 COG0457@1|root,COG3063@1|root,COG0457@2|Bacteria,COG3063@2|Bacteria,1MXMD@1224|Proteobacteria,42NZK@68525|delta/epsilon subdivisions,2WIY5@28221|Deltaproteobacteria,2MJAV@213118|Desulfobacterales 28221|Deltaproteobacteria O Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8,zinc_ribbon_4 k59_890621_1 471852.Tcur_1518 1.76e-41 156.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,2GIYE@201174|Actinobacteria,4EMF2@85012|Streptosporangiales 201174|Actinobacteria EQ Hydantoinase B/oxoprolinase oplA - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - iNJ661.Rv0266c Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_1047202_2 1122212.AULO01000011_gene553 1.86e-27 109.0 COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,1RNMJ@1236|Gammaproteobacteria,1XNNX@135619|Oceanospirillales 135619|Oceanospirillales C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_11 k59_472194_1 557599.MKAN_09615 1.34e-56 196.0 COG1020@1|root,COG1020@2|Bacteria,2GKU0@201174|Actinobacteria,235TY@1762|Mycobacteriaceae 201174|Actinobacteria Q Diacylglycerol O-acyltransferase - - - - - - - - - - - - DUF1298,WES_acyltransf k59_263710_1 1126627.BAWE01000004_gene4069 3.82e-131 385.0 COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria,3JWB9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP,TAT_signal k59_890624_1 861299.J421_3771 2.17e-84 270.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1ZT01@142182|Gemmatimonadetes 2|Bacteria C Phosphate acetyl/butaryl transferase maeB GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 ko:K00027,ko:K00029,ko:K00625,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02020,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200,map02020 M00169,M00172,M00357,M00579 R00214,R00216,R00230,R00921 RC00004,RC00105,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1637 Malic_M,PTA_PTB,malic k59_1256604_1 314266.SKA58_13062 0.000773 46.2 COG0790@1|root,COG3147@1|root,COG0790@2|Bacteria,COG3147@2|Bacteria,1RJ71@1224|Proteobacteria,2U15P@28211|Alphaproteobacteria,2K032@204457|Sphingomonadales 204457|Sphingomonadales S FOG TPR repeat, SEL1 subfamily - - - ko:K07126 - - - - ko00000 - - - SPOR,Sel1 k59_576931_1 706587.Desti_1993 6.82e-69 218.0 COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,42Y9P@68525|delta/epsilon subdivisions,2WTX5@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_316022_1 1007105.PT7_3472 2.29e-05 47.0 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,2VRSR@28216|Betaproteobacteria,3T98M@506|Alcaligenaceae 28216|Betaproteobacteria S Predicted membrane protein (DUF2238) yjdF - - ko:K08984 - - - - ko00000 - - - DUF2238 k59_263717_2 56780.SYN_00186 3.78e-05 44.7 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,42U00@68525|delta/epsilon subdivisions,2WQD4@28221|Deltaproteobacteria,2MQKE@213462|Syntrophobacterales 28221|Deltaproteobacteria U Biopolymer transport protein ExbD/TolR tolR - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_1621830_2 1165096.ARWF01000001_gene2252 3.58e-42 150.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,2KKB0@206350|Nitrosomonadales 206350|Nitrosomonadales M TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_106626_1 1156844.KB891849_gene3309 2.19e-105 317.0 COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria 201174|Actinobacteria I Belongs to the thiolase family - - - - - - - - - - - - Thiolase_N,ketoacyl-synt k59_472208_1 1282876.BAOK01000001_gene3037 9.02e-71 230.0 COG0318@1|root,COG0318@2|Bacteria,1MUIC@1224|Proteobacteria,2TUFX@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.7 ko:K15868 ko00121,map00121 - - - ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_1256617_1 177437.HRM2_41800 1.58e-132 392.0 2DBU2@1|root,2ZB3S@2|Bacteria,1N1MT@1224|Proteobacteria,42VJX@68525|delta/epsilon subdivisions,2WSPP@28221|Deltaproteobacteria,2MNKM@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - DDE_Tnp_1_4 k59_316035_1 977880.RALTA_A2615 6.46e-159 471.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,1K2G2@119060|Burkholderiaceae 28216|Betaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_524832_1 243231.GSU0434 6.61e-73 229.0 COG0301@1|root,COG0301@2|Bacteria,1N1R1@1224|Proteobacteria,42MQ9@68525|delta/epsilon subdivisions,2WJPN@28221|Deltaproteobacteria,43T42@69541|Desulfuromonadales 28221|Deltaproteobacteria H Thiamine biosynthesis protein (ThiI) - - - - - - - - - - - - DUF814,ThiI k59_1516493_1 1123373.ATXI01000011_gene1116 4.76e-57 197.0 COG0013@1|root,COG0013@2|Bacteria,2GH36@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_994614_1 313628.LNTAR_12066 2.88e-13 75.1 COG1413@1|root,COG2133@1|root,COG2863@1|root,COG3794@1|root,COG3828@1|root,COG1413@2|Bacteria,COG2133@2|Bacteria,COG2863@2|Bacteria,COG3794@2|Bacteria,COG3828@2|Bacteria 2|Bacteria N Trehalose utilisation - - - ko:K06893,ko:K09992 - - - - ko00000 - - - CARDB,Copper-bind,Cytochrom_C,HEAT_2,Lipase_GDSL_2,ThuA k59_994614_3 382464.ABSI01000010_gene3669 1.12e-32 121.0 COG1622@1|root,COG1622@2|Bacteria,46SPQ@74201|Verrucomicrobia,2IU8P@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Cytochrome C oxidase subunit II, periplasmic domain - - - - - - - - - - - - COX2 k59_263727_1 1278073.MYSTI_06805 2.49e-128 400.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2YUFE@29|Myxococcales 28221|Deltaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_316041_1 561230.PC1_3012 2.52e-09 60.5 COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria,1MPR3@122277|Pectobacterium 1236|Gammaproteobacteria S Tetratricopeptide repeat-like domain yfgM GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0044425,GO:0044459,GO:0044464,GO:0071575,GO:0071944,GO:0098552 - - - - - - - - - - TPR_21 k59_420408_1 105559.Nwat_1369 6.65e-56 201.0 COG1033@1|root,COG1033@2|Bacteria,1QW3H@1224|Proteobacteria,1RZA3@1236|Gammaproteobacteria,1X2NT@135613|Chromatiales 135613|Chromatiales S TIGRFAM hopanoid biosynthesis associated RND transporter like protein HpnN - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1151462_1 582744.Msip34_2008 1.31e-07 58.5 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,2KMD8@206350|Nitrosomonadales 206350|Nitrosomonadales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_14,TPR_16,TPR_19,TPR_2,TPR_8 k59_1099582_1 1167006.UWK_02072 2.91e-08 53.5 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2WJGN@28221|Deltaproteobacteria,2MIGC@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_1099582_2 330214.NIDE1339 1.02e-109 323.0 COG0202@1|root,COG0202@2|Bacteria,3J0AR@40117|Nitrospirae 40117|Nitrospirae K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_994622_2 697282.Mettu_2727 2.17e-19 90.9 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1XEMV@135618|Methylococcales 135618|Methylococcales J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_211452_1 667014.Thein_1717 1.94e-66 225.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GHDG@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1151471_1 1192034.CAP_4552 7.6e-149 432.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,2YUBT@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_263743_1 83406.HDN1F_28550 2.5e-22 100.0 COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,1RP5E@1236|Gammaproteobacteria 1236|Gammaproteobacteria N transport system involved in gliding motility, auxiliary component - - - - - - - - - - - - ABC_transp_aux k59_263743_2 395493.BegalDRAFT_1704 5.46e-19 83.6 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,46210@72273|Thiotrichales 72273|Thiotrichales S CcmB protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3 k59_994630_2 981384.AEYW01000006_gene2637 3.4e-30 115.0 299ER@1|root,2ZWHI@2|Bacteria,1RAA3@1224|Proteobacteria,2U904@28211|Alphaproteobacteria,4NBZK@97050|Ruegeria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_942474_1 1333998.M2A_0192 2.66e-17 82.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,4BPMG@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J tRNA synthetases class I (I, L, M and V) leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_942474_2 1120919.AUBI01000002_gene1077 6.93e-15 75.9 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2TRD8@28211|Alphaproteobacteria,2JPAB@204441|Rhodospirillales 204441|Rhodospirillales O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_368302_1 436308.Nmar_0954 2.94e-103 313.0 COG1884@1|root,arCOG04232@2157|Archaea,41SBW@651137|Thaumarchaeota 651137|Thaumarchaeota I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_842830_1 933262.AXAM01000017_gene3105 1.15e-51 184.0 COG4191@1|root,COG4191@2|Bacteria,1R9AK@1224|Proteobacteria,42Q2G@68525|delta/epsilon subdivisions,2WM8Y@28221|Deltaproteobacteria,2MI84@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1210244_1 472759.Nhal_2239 2.82e-82 251.0 COG0356@1|root,COG0356@2|Bacteria,1RBEV@1224|Proteobacteria,1T170@1236|Gammaproteobacteria 1236|Gammaproteobacteria C it plays a direct role in the translocation of protons across the membrane - - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1210244_2 297246.lpp2332 8.81e-36 123.0 COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,1SA80@1236|Gammaproteobacteria,1JEPA@118969|Legionellales 118969|Legionellales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation - - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_61001_1 631454.N177_3142 7.94e-68 226.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR38@28211|Alphaproteobacteria,1JPXQ@119043|Rhodobiaceae 28211|Alphaproteobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_61001_2 1114964.L485_10130 6.24e-33 118.0 2C3CF@1|root,32RRR@2|Bacteria,1MZUG@1224|Proteobacteria,2UC1Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3175) - - - - - - - - - - - - DUF3175 k59_1262339_1 391038.Bphy_5277 5.39e-52 181.0 COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2VKG2@28216|Betaproteobacteria,1K3IK@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the LDH2 MDH2 oxidoreductase family ybiC - - ko:K13574 - - - - ko00000,ko01000 - - - Ldh_2 k59_1470449_2 631362.Thi970DRAFT_04388 6.76e-13 70.5 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,1WW9T@135613|Chromatiales 135613|Chromatiales P PFAM Citrate transporter - - - - - - - - - - - - CitMHS k59_792165_1 1280950.HJO_08819 1.29e-81 257.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria,43X5N@69657|Hyphomonadaceae 28211|Alphaproteobacteria P flavoprotein involved in K transport - - - - - - - - - - - - FMO-like,K_oxygenase,Pyr_redox_3 k59_1104200_1 396588.Tgr7_1108 1.67e-09 55.8 COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,1S73Y@1236|Gammaproteobacteria,1X24K@135613|Chromatiales 135613|Chromatiales S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_946610_1 748247.AZKH_4214 9.12e-22 94.7 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,2KVNM@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the dGTPase family. Type 2 subfamily dgt1 - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_946610_2 713586.KB900536_gene1841 1.37e-20 90.5 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_635580_1 1136163.M565_ctg5P1091 0.000455 48.5 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,1XW4M@135623|Vibrionales 135623|Vibrionales S AAA domain (dynein-related subfamily) cobS - 6.6.1.2 ko:K09882 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - AAA_5,CbbQ_C,CobS_N k59_1051908_2 314345.SPV1_10726 1.94e-21 104.0 COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria 1224|Proteobacteria MU Outer membrane efflux protein czcC - - ko:K15725 - - - - ko00000,ko02000 1.B.17.2.2 - - OEP k59_1051908_3 1121859.KB890739_gene2587 0.000506 47.8 COG0845@1|root,COG0845@2|Bacteria,4NG8S@976|Bacteroidetes,47K97@768503|Cytophagia 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cusB - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - DUF3347,HlyD_D23,HlyD_D4 k59_1051908_4 760568.Desku_2684 8.49e-26 109.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,263WG@186807|Peptococcaceae 186801|Clostridia KT tigrfam pas prdR - - - - - - - - - - - CBS,HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat k59_215796_1 224911.27353343 1.45e-23 104.0 COG3203@1|root,COG3203@2|Bacteria,1Q96Q@1224|Proteobacteria,2U9II@28211|Alphaproteobacteria,3K2DE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M outer membrane porin, OprD family - - - - - - - - - - - - OprD k59_110846_1 394221.Mmar10_1457 1.86e-16 86.3 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,2TWZ1@28211|Alphaproteobacteria,44159@69657|Hyphomonadaceae 28211|Alphaproteobacteria K cAMP biosynthetic process - - - - - - - - - - - - Guanylate_cyc,Trans_reg_C k59_635593_1 247490.KSU1_B0261 9.92e-37 139.0 COG2180@1|root,COG2180@2|Bacteria,2J2F8@203682|Planctomycetes 203682|Planctomycetes C Ethylbenzene dehydrogenase - - - - - - - - - - - - EB_dh k59_215804_1 485913.Krac_8942 2.22e-39 144.0 COG2141@1|root,COG2141@2|Bacteria,2G8CA@200795|Chloroflexi 200795|Chloroflexi C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_895298_1 396588.Tgr7_2744 3.04e-41 153.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales 135613|Chromatiales O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_1573530_1 1175306.GWL_09540 2.33e-09 58.2 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,47368@75682|Oxalobacteraceae 28216|Betaproteobacteria I PFAM Acyl-CoA dehydrogenase N terminal, Acyl-CoA dehydrogenase, C-terminal domain, Acyl-CoA dehydrogenase, middle domain, Acyl-CoA dehydrogenase, N-terminal domain - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_1573530_2 991905.SL003B_4332 1.18e-78 241.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,4BPKP@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I enoyl-CoA hydratase isomerase family paaF - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1519533_1 323261.Noc_0301 3.12e-33 116.0 COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,1SCJS@1236|Gammaproteobacteria,1WYXS@135613|Chromatiales 135613|Chromatiales S Regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 k59_110853_1 261292.Nit79A3_2847 3.82e-43 155.0 COG2170@1|root,COG2170@2|Bacteria,1MY35@1224|Proteobacteria,2VNEE@28216|Betaproteobacteria,3743G@32003|Nitrosomonadales 28216|Betaproteobacteria H Glutamate-cysteine ligase family 2(GCS2) - - - - - - - - - - - - GCS2 k59_529092_1 1229909.NSED_08190 1.24e-76 245.0 COG0072@1|root,arCOG00412@2157|Archaea,41S8M@651137|Thaumarchaeota 651137|Thaumarchaeota J phenylalanyl-tRNA synthetase, beta subunit - - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5 k59_1051936_1 1232410.KI421425_gene1552 2.01e-139 440.0 COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales 28221|Deltaproteobacteria M OmpA family - - - - - - - - - - - - OmpA k59_372570_1 545276.KB898725_gene644 7.02e-69 214.0 COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria,1WX78@135613|Chromatiales 135613|Chromatiales C Protein of unknown function (DUF3501) - - - - - - - - - - - - DUF3501 k59_321060_1 1123399.AQVE01000031_gene206 1.53e-118 377.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,45ZNT@72273|Thiotrichales 72273|Thiotrichales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1519537_1 1123269.NX02_08415 4.81e-33 130.0 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,2KD3U@204457|Sphingomonadales 204457|Sphingomonadales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1210306_1 1121405.dsmv_0381 6.27e-76 244.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WJY2@28221|Deltaproteobacteria,2MHX0@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1210306_2 177437.HRM2_34710 1.38e-15 74.3 COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,42TGN@68525|delta/epsilon subdivisions,2WQ04@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Haloacid dehalogenase-like hydrolase - - 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 k59_1365110_1 1173022.Cri9333_0076 4.74e-23 100.0 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7T9@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_1104245_2 494416.AYXN01000041_gene612 5.5e-15 77.8 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,1RN9B@1236|Gammaproteobacteria,3NJIN@468|Moraxellaceae 1236|Gammaproteobacteria C CoA-transferase family III - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_372581_1 59538.XP_005981811.1 1.82e-70 228.0 COG0221@1|root,KOG1681@1|root,KOG1626@2759|Eukaryota,KOG1681@2759|Eukaryota,38TRP@33154|Opisthokonta,3BCWE@33208|Metazoa,3CZK6@33213|Bilateria,481G7@7711|Chordata,490Y7@7742|Vertebrata,3JEJ8@40674|Mammalia,4J3VF@91561|Cetartiodactyla 33208|Metazoa I delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 - ko:K12663 ko04146,map04146 - - - ko00000,ko00001,ko01000 - - - ECH_1 k59_1470521_1 1049564.TevJSym_ao00540 2.19e-74 229.0 COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,1RP27@1236|Gammaproteobacteria,1J5ZA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S hydrolase (HAD superfamily) yrfG GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484 3.1.3.5 ko:K20881 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase k59_1470521_2 62928.azo2753 2.61e-23 92.0 2CU7M@1|root,32SUS@2|Bacteria,1N1WF@1224|Proteobacteria,2VUS0@28216|Betaproteobacteria,2KWRI@206389|Rhodocyclales 206389|Rhodocyclales S SpoIIAA-like - - - - - - - - - - - - SpoIIAA-like k59_792237_1 445686.E3SL58_9CAUD 1.2e-137 406.0 4QES4@10239|Viruses,4QXT9@35237|dsDNA viruses no RNA stage,4QQEY@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_792237_2 444860.E3SJ05_9CAUD 1.09e-25 97.1 4QIZ2@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_425004_1 349124.Hhal_1468 4.49e-137 418.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales 135613|Chromatiales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_635636_1 998088.B565_3190 1.94e-17 78.6 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,1Y4DC@135624|Aeromonadales 135624|Aeromonadales S Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_738169_2 1049564.TevJSym_bb00050 9.17e-86 276.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1365123_2 485915.Dret_1096 1.01e-17 80.1 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,42SCQ@68525|delta/epsilon subdivisions,2WPZQ@28221|Deltaproteobacteria,2MAU8@213115|Desulfovibrionales 28221|Deltaproteobacteria J binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_1470523_1 1123368.AUIS01000001_gene2023 3.14e-60 203.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,2NCS6@225057|Acidithiobacillales 225057|Acidithiobacillales E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_946651_1 686340.Metal_3894 2.85e-16 83.2 COG3055@1|root,COG3291@1|root,COG3055@2|Bacteria,COG3291@2|Bacteria,1QXQ7@1224|Proteobacteria,1T3G4@1236|Gammaproteobacteria,1XGBG@135618|Methylococcales 135618|Methylococcales M Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - - k59_372585_1 1198232.CYCME_1781 3.63e-90 281.0 COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria,463WT@72273|Thiotrichales 72273|Thiotrichales CP Proton-conducting membrane transporter - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_372585_2 458817.Shal_3361 3.52e-05 45.8 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,2QAGX@267890|Shewanellaceae 1236|Gammaproteobacteria C PFAM NADH Ubiquinone plastoquinone (complex I) - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_1262423_1 1493511.A0A0E3HNQ1_9CAUD 8.93e-67 207.0 4QJQ6@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_61094_1 1192124.LIG30_4112 6.89e-45 164.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,1K6DP@119060|Burkholderiaceae 28216|Betaproteobacteria T Chase2 domain cyaA - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_635641_1 1229780.BN381_500017 9.02e-17 77.4 COG0500@1|root,COG2226@2|Bacteria,2HFQC@201174|Actinobacteria,3UXKF@52018|unclassified Actinobacteria (class) 201174|Actinobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_25 k59_635641_2 32057.KB217478_gene2897 3.42e-67 210.0 COG0625@1|root,COG0625@2|Bacteria,1G34I@1117|Cyanobacteria,1HKU4@1161|Nostocales 1117|Cyanobacteria O Belongs to the GST superfamily - - 2.5.1.18 ko:K00799,ko:K11209 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N,GST_N_3 k59_895338_1 1458427.BAWN01000050_gene2144 3.1e-123 363.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2VJ1W@28216|Betaproteobacteria,4A9MM@80864|Comamonadaceae 28216|Betaproteobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_1210329_1 56107.Cylst_5499 0.000252 52.0 COG0457@1|root,COG1672@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,1G1QI@1117|Cyanobacteria,1HJWQ@1161|Nostocales 1117|Cyanobacteria K PFAM Tetratricopeptide repeat - - - - - - - - - - - - NB-ARC,TPR_10,TPR_12,TPR_7,TPR_8 k59_1573566_2 1205908.AKXW01000109_gene1474 1.42e-08 56.6 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGC@1236|Gammaproteobacteria,1Y0A3@135623|Vibrionales 135623|Vibrionales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_998854_1 869724.H6BHY2_9CAUD 4.49e-27 100.0 4QDJQ@10239|Viruses,4QV61@35237|dsDNA viruses no RNA stage,4QRTM@28883|Caudovirales,4QIUC@10662|Myoviridae 10662|Myoviridae S CP12 domain - - - - - - - - - - - - - k59_998854_2 268746.Q58MY5_BPPRM 1.29e-30 130.0 4QFTZ@10239|Viruses,4QR6C@28883|Caudovirales,4QJM6@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1156109_1 521003.COLINT_02441 2.13e-11 63.5 COG1994@1|root,COG1994@2|Bacteria,2GM8E@201174|Actinobacteria,4CUK0@84998|Coriobacteriia 84998|Coriobacteriia S Peptidase M50 - - - - - - - - - - - - Peptidase_M50 k59_895343_1 105559.Nwat_0059 6.64e-97 317.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1417331_2 765910.MARPU_10870 3.34e-31 116.0 2E6CU@1|root,3310G@2|Bacteria,1NBK1@1224|Proteobacteria,1S5EP@1236|Gammaproteobacteria,1WYBI@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_111375_1 635013.TherJR_2549 5.91e-13 67.4 2DPEW@1|root,331SY@2|Bacteria,1VH50@1239|Firmicutes,24RTN@186801|Clostridia,262U9@186807|Peptococcaceae 186801|Clostridia S Domain of unknown function (DUF4321) - - - - - - - - - - - - DUF4321 k59_3840_1 391615.ABSJ01000032_gene712 1.71e-32 123.0 COG2242@1|root,COG2242@2|Bacteria,1R79F@1224|Proteobacteria,1RY3Z@1236|Gammaproteobacteria,1J8AJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H protein methyltransferase activity - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_1156632_1 243233.MCA1466 1.95e-80 256.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1XE1C@135618|Methylococcales 135618|Methylococcales J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_1471300_1 886293.Sinac_1127 1.3e-23 105.0 COG0531@1|root,COG0531@2|Bacteria,2IYSD@203682|Planctomycetes 203682|Planctomycetes E Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_636473_1 396588.Tgr7_2406 4.09e-84 264.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1WX4H@135613|Chromatiales 135613|Chromatiales M PFAM peptidase - - - - - - - - - - - - OapA,Peptidase_M23 k59_529747_1 518766.Rmar_1377 1.64e-10 59.3 COG3019@1|root,COG3019@2|Bacteria,4P644@976|Bacteroidetes,1FJE9@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Protein of unknown function, DUF - - - - - - - - - - - - DUF411 k59_529747_2 316067.Geob_0817 1.19e-09 63.9 COG2259@1|root,COG2259@2|Bacteria,1RIFW@1224|Proteobacteria,42UDR@68525|delta/epsilon subdivisions,2WR26@28221|Deltaproteobacteria,43SQ4@69541|Desulfuromonadales 28221|Deltaproteobacteria S Methylamine utilisation protein MauE - - - - - - - - - - - - MauE k59_636478_1 436308.Nmar_0380 4.6e-92 280.0 arCOG10517@1|root,arCOG10517@2157|Archaea,41T0I@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1626878_2 349521.HCH_05069 1.66e-35 125.0 2CJPW@1|root,32SAH@2|Bacteria,1NAJ3@1224|Proteobacteria,1SAPE@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_947186_1 1123253.AUBD01000012_gene1001 3.28e-35 135.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1X4NW@135614|Xanthomonadales 135614|Xanthomonadales P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_1211125_2 1265313.HRUBRA_00036 4.87e-32 117.0 COG0517@1|root,COG0517@2|Bacteria 2|Bacteria S IMP dehydrogenase activity - - - ko:K04767,ko:K07168,ko:K07182 - - - - ko00000 - - - CBS k59_529752_1 1174528.JH992898_gene2656 7.32e-61 203.0 COG1249@1|root,COG1249@2|Bacteria,1G198@1117|Cyanobacteria,1JHHX@1189|Stigonemataceae 1117|Cyanobacteria C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain merA - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_373245_1 870187.Thini_0631 1.09e-78 251.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,45ZWP@72273|Thiotrichales 72273|Thiotrichales M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_1263246_1 1229909.NSED_06305 9.99e-29 105.0 COG5431@1|root,arCOG01120@2157|Archaea,41SW3@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1267670_2 439235.Dalk_0595 1.13e-43 164.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42QGA@68525|delta/epsilon subdivisions,2WJYS@28221|Deltaproteobacteria,2MI4W@213118|Desulfobacterales 28221|Deltaproteobacteria M MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_640940_1 999423.HMPREF9161_01097 4.11e-75 238.0 COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,4H2IA@909932|Negativicutes 909932|Negativicutes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_272413_1 472759.Nhal_0349 3.54e-93 285.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_640944_1 671143.DAMO_0143 4.69e-56 180.0 COG1881@1|root,COG1881@2|Bacteria,2NPDK@2323|unclassified Bacteria 2|Bacteria S Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_429039_1 452637.Oter_2161 8.33e-57 189.0 COG4307@1|root,COG4307@2|Bacteria 2|Bacteria T Protein conserved in bacteria - - - - - - - - - - - - Peptidase_Mx,zinc-ribbon_6 k59_640945_1 290397.Adeh_1904 2.31e-38 142.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,42R3H@68525|delta/epsilon subdivisions,2WMNY@28221|Deltaproteobacteria,2YUZU@29|Myxococcales 28221|Deltaproteobacteria D NUBPL iron-transfer P-loop NTPase - - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,CbiA,HTH_25,ParA k59_1475720_1 1380370.JIBA01000013_gene1557 0.000975 43.1 COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,2GK62@201174|Actinobacteria,4FFVK@85021|Intrasporangiaceae 201174|Actinobacteria KOT Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_3,Response_reg k59_1215072_1 697282.Mettu_3168 6.81e-101 300.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1XDWP@135618|Methylococcales 135618|Methylococcales E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_220015_2 1197130.BAFM01000001_gene22 3.85e-07 56.2 COG3119@1|root,arCOG02785@2157|Archaea,2Y8G5@28890|Euryarchaeota,241AK@183963|Halobacteria 183963|Halobacteria P COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - Sulfatase k59_272422_1 444860.E3SJF8_9CAUD 1.05e-114 333.0 4QAUS@10239|Viruses,4QURX@35237|dsDNA viruses no RNA stage,4QQ2S@28883|Caudovirales 28883|Caudovirales S flavin adenine dinucleotide binding - - - - - - - - - - - - - k59_272422_2 445686.E3SLN4_9CAUD 1.04e-34 120.0 4QAPD@10239|Viruses,4R013@35237|dsDNA viruses no RNA stage,4QR1V@28883|Caudovirales,4QK6E@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_220018_1 999611.KI421504_gene3518 7.06e-33 127.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,27ZV8@191028|Leisingera 28211|Alphaproteobacteria O SPFH domain / Band 7 family hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_220018_2 1121438.JNJA01000002_gene3354 0.000243 46.6 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,42N2V@68525|delta/epsilon subdivisions,2WIPS@28221|Deltaproteobacteria,2M7XX@213115|Desulfovibrionales 28221|Deltaproteobacteria O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_1630676_1 1122132.AQYH01000003_gene3182 3.86e-41 148.0 COG0500@1|root,COG2226@2|Bacteria,1RKPU@1224|Proteobacteria,2UDN5@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k59_1630676_2 745014.OMB55_00019380 4.09e-24 97.8 2E991@1|root,333HB@2|Bacteria 2|Bacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_3 k59_1422139_1 765911.Thivi_4487 3.02e-33 132.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1WW7V@135613|Chromatiales 135613|Chromatiales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1003075_1 1215114.BBIU01000028_gene3330 4.82e-48 171.0 COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,1RN73@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA GO:0003674,GO:0003824,GO:0004125,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0090304,GO:0097056,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - iECP_1309.ECP_3693,iSbBS512_1146.SbBS512_E4006 Se-cys_synth_N,SelA k59_798000_2 1121271.AUCM01000015_gene2513 1.21e-25 106.0 COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2TSQ2@28211|Alphaproteobacteria 28211|Alphaproteobacteria P protein involved in response to NO nnrS - - ko:K07234 - - - - ko00000 - - - NnrS k59_1267706_1 1415779.JOMH01000001_gene1020 1.94e-06 52.8 2DA4I@1|root,32TUN@2|Bacteria,1N0WK@1224|Proteobacteria,1S6HI@1236|Gammaproteobacteria,1X665@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_1267706_2 981223.AIED01000025_gene1479 2.5e-10 60.1 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,3NJA9@468|Moraxellaceae 1236|Gammaproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - iSSON_1240.SSON_4131 Semialdhyde_dh,Semialdhyde_dhC k59_1316376_1 1121374.KB891588_gene3342 1.26e-13 71.2 COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RP1C@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the glutamate synthase family - - - - - - - - - - - - Glu_synthase k59_1316376_2 754477.Q7C_1183 8.33e-104 318.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,4601B@72273|Thiotrichales 72273|Thiotrichales EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1630684_1 555778.Hneap_0610 1.82e-23 99.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1WVVJ@135613|Chromatiales 135613|Chromatiales F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_1630684_2 1116472.MGMO_83c00160 9.98e-57 191.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1XESH@135618|Methylococcales 135618|Methylococcales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_846891_1 765913.ThidrDRAFT_0011 4.74e-54 179.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1WWR6@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator, LysR - - - ko:K21703 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_846891_2 481448.Minf_1683 6.01e-29 111.0 COG3954@1|root,COG3954@2|Bacteria,46YX7@74201|Verrucomicrobia,37GDM@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia C Phosphoribulokinase / Uridine kinase family - - 2.7.1.19 ko:K00855 ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200 M00165,M00166 R01523 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PRK k59_1267716_1 382359.Q0QZ76_BPSYS 2.21e-22 88.6 4QE3B@10239|Viruses,4QVUK@35237|dsDNA viruses no RNA stage,4QSFR@28883|Caudovirales,4QIBB@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1316381_1 2340.JV46_14060 7.15e-78 246.0 COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,1RS2Z@1236|Gammaproteobacteria,1J92V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Amidase - - - - - - - - - - - - Amidase k59_1316381_2 1211115.ALIQ01000243_gene3768 7.94e-28 111.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system large permease component - - - - - - - - - - - - DctM k59_1108267_1 1215092.PA6_010_01680 1.63e-35 125.0 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria,1YFXA@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Polyketide cyclase / dehydrase and lipid transport ratA GO:0003674,GO:0005488,GO:0006417,GO:0006446,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044877,GO:0045947,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113 - - - - - - - - - - Polyketide_cyc k59_1108267_2 1042375.AFPL01000030_gene504 2.42e-59 203.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,465HT@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG0733 Na -dependent transporters of the SNF family IV02_29000 - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_482036_2 926566.Terro_4321 4.98e-43 150.0 COG1606@1|root,COG1606@2|Bacteria,3Y30C@57723|Acidobacteria,2JKD3@204432|Acidobacteriia 204432|Acidobacteriia L tRNA processing - - - ko:K06864 - - - - ko00000 - - - NAD_synthase k59_1369187_1 931276.Cspa_c37500 1.13e-22 102.0 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248K6@186801|Clostridia,36HSF@31979|Clostridiaceae 186801|Clostridia L PFAM Reverse transcriptase (RNA-dependent DNA polymerase) - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1,RVT_N k59_1159627_1 314285.KT71_11825 1.1e-47 161.0 COG0625@1|root,COG0625@2|Bacteria,1PHM1@1224|Proteobacteria,1RMVC@1236|Gammaproteobacteria,1J6GR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_N_2,GST_N_3 k59_220632_1 379066.GAU_3920 6.72e-31 125.0 COG3291@1|root,COG4932@1|root,COG3291@2|Bacteria,COG4932@2|Bacteria,1ZTYD@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Leishmanolysin - - - - - - - - - - - - Peptidase_M8 k59_377556_1 620914.JH621251_gene2316 3.21e-20 94.7 COG2373@1|root,COG3420@1|root,COG4932@1|root,COG2373@2|Bacteria,COG3420@2|Bacteria,COG4932@2|Bacteria,4PNM0@976|Bacteroidetes,1IK8U@117743|Flavobacteriia,2YM5U@290174|Aquimarina 976|Bacteroidetes P Right handed beta helix region - - - - - - - - - - - - Beta_helix k59_847461_2 1454004.AW11_01460 2.47e-49 166.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VNVE@28216|Betaproteobacteria,1KR8I@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain frdB - 1.3.5.4 ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 k59_1578193_1 391615.ABSJ01000030_gene806 5.55e-55 183.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1J4MQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_1578193_2 395493.BegalDRAFT_1644 2.6e-12 66.6 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria,461AZ@72273|Thiotrichales 72273|Thiotrichales K Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves - - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_1268437_2 1141136.K4F9L0_9CAUD 3.65e-08 57.8 4QAJ5@10239|Viruses,4QUS9@35237|dsDNA viruses no RNA stage,4QPY5@28883|Caudovirales,4QHUT@10662|Myoviridae 10662|Myoviridae S Major capsid protein Gp23 - GO:0005575,GO:0019012,GO:0019028,GO:0044423 - - - - - - - - - - - k59_1369719_1 1411123.JQNH01000001_gene3832 9.51e-31 127.0 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,BTAD,DZR,Guanylate_cyc,SAM_2,TPR_12 k59_325729_1 760011.Spico_1011 2.51e-26 105.0 COG0280@1|root,COG0280@2|Bacteria,2J5DS@203691|Spirochaetes 203691|Spirochaetes C phosphate acetyltransferase pta - 2.3.1.8 ko:K00625 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - PTA_PTB k59_1268448_1 634497.HAH_0920 1.07e-13 75.1 COG0330@1|root,arCOG01915@2157|Archaea,2XTT5@28890|Euryarchaeota,23UP1@183963|Halobacteria 183963|Halobacteria O COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - - - - - - - - - - Band_7 k59_429631_1 1163409.UUA_06354 7.03e-28 109.0 COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,1RP85@1236|Gammaproteobacteria,1X52R@135614|Xanthomonadales 135614|Xanthomonadales I enoyl-CoA hydratase - - 4.2.1.18 ko:K13766 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_220656_1 998674.ATTE01000001_gene2373 3.86e-45 159.0 COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,1SZQ8@1236|Gammaproteobacteria,46328@72273|Thiotrichales 72273|Thiotrichales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_847476_1 1452718.JBOY01000055_gene1733 2.2e-46 156.0 COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,1T06D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_429635_1 314225.ELI_10795 5.3e-13 68.2 COG0614@1|root,COG0614@2|Bacteria,1RBT1@1224|Proteobacteria,2UZCU@28211|Alphaproteobacteria,2K8MM@204457|Sphingomonadales 204457|Sphingomonadales P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_899952_1 1279017.AQYJ01000024_gene860 2.28e-112 339.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,4648A@72275|Alteromonadaceae 1236|Gammaproteobacteria K Participates in both transcription termination and antitermination nusA GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_482759_1 1123261.AXDW01000011_gene604 7.85e-45 158.0 COG1960@1|root,COG1960@2|Bacteria,1P4V3@1224|Proteobacteria,1RZBS@1236|Gammaproteobacteria,1X4VS@135614|Xanthomonadales 135614|Xanthomonadales I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_325738_2 357804.Ping_0952 8.02e-20 93.6 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG1022 Long-chain acyl-CoA synthetases (AMP-forming) - - - - - - - - - - - - AMP-binding,Haem_oxygenas_2 k59_1476503_2 666681.M301_0481 3.63e-28 107.0 COG2197@1|root,COG2197@2|Bacteria,1NDB6@1224|Proteobacteria,2WF3F@28216|Betaproteobacteria 28216|Betaproteobacteria T Pfam Response regulator receiver - - - - - - - - - - - - Response_reg k59_1422970_2 472759.Nhal_3587 2.98e-133 390.0 COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,1SKJ8@1236|Gammaproteobacteria,1X0FH@135613|Chromatiales 135613|Chromatiales F Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C k59_1422970_3 472759.Nhal_3601 6.51e-152 442.0 COG0861@1|root,COG0861@2|Bacteria,1MUNR@1224|Proteobacteria,1RP9Y@1236|Gammaproteobacteria,1WWGU@135613|Chromatiales 135613|Chromatiales P PFAM Integral membrane protein TerC - - - ko:K05794 - - - - ko00000 - - - PGPGW,TerC k59_1422970_4 861299.J421_3809 1.46e-08 55.5 COG0058@1|root,COG0058@2|Bacteria,1ZSZ3@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Carbohydrate phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_1160158_1 1304885.AUEY01000037_gene2175 5.66e-26 107.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2WJQ2@28221|Deltaproteobacteria,2MIIV@213118|Desulfobacterales 28221|Deltaproteobacteria H PFAM aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1160158_2 1082933.MEA186_34059 6.66e-08 53.9 COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,2UFJJ@28211|Alphaproteobacteria,43KZI@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex atpI - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 k59_692568_1 1114964.L485_05350 3.94e-51 177.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2TVFM@28211|Alphaproteobacteria,2K114@204457|Sphingomonadales 204457|Sphingomonadales J Metallo-beta-lactamase superfamily domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_1215758_1 1158150.KB906241_gene917 5.88e-98 288.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,1WVVY@135613|Chromatiales 135613|Chromatiales E imidazoleglycerol-phosphate dehydratase hisB - 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD k59_1215758_2 1123368.AUIS01000003_gene1631 4.99e-97 297.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,2NCPX@225057|Acidithiobacillales 225057|Acidithiobacillales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_742748_1 330214.NIDE3373 4.44e-29 114.0 COG1262@1|root,COG1262@2|Bacteria 2|Bacteria T PFAM Formylglycine-generating sulfatase enzyme - - - ko:K20333 ko02024,map02024 - - - ko00000,ko00001 - - - FGE-sulfatase,NACHT k59_1003744_1 324057.Pjdr2_2108 9.5e-46 168.0 COG2843@1|root,COG2843@2|Bacteria,1UCFI@1239|Firmicutes,4HE5R@91061|Bacilli,274YW@186822|Paenibacillaceae 91061|Bacilli M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_1422979_1 436308.Nmar_1242 2.56e-61 195.0 COG1630@1|root,arCOG00367@2157|Archaea,41SJX@651137|Thaumarchaeota 651137|Thaumarchaeota L NurA - - - - - - - - - - - - NurA k59_1476518_1 1163617.SCD_n02941 1.76e-75 236.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria 28216|Betaproteobacteria NU Type IV pilus assembly protein PilM pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_1631321_1 436308.Nmar_0977 8.23e-126 371.0 COG0702@1|root,arCOG03015@2157|Archaea 2157|Archaea GM NAD-dependent epimerase dehydratase - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - NAD_binding_10 k59_166294_2 522306.CAP2UW1_3206 2.52e-49 163.0 COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2VQFX@28216|Betaproteobacteria 28216|Betaproteobacteria Q intradiol ring-cleavage dioxygenase - - 1.13.11.3 ko:K00449 ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220 - R01631,R03549 RC00388,RC00953 br01602,ko00000,ko00001,ko01000 - - - Dioxygenase_C k59_429658_1 1301098.PKB_4315 4.43e-242 681.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.41 ko:K18687 ko00984,ko01100,ko01120,map00984,map01100,map01120 - R10769 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_1274443_1 1382359.JIAL01000001_gene2653 1.97e-09 58.5 COG0566@1|root,COG0566@2|Bacteria,3Y3XM@57723|Acidobacteria,2JII0@204432|Acidobacteriia 204432|Acidobacteriia J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family - - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_697002_1 237727.NAP1_06055 1.62e-33 132.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JZZC@204457|Sphingomonadales 204457|Sphingomonadales E Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_851899_1 908612.HMPREF9720_0487 3.23e-23 99.0 COG0112@1|root,COG0112@2|Bacteria,4NE30@976|Bacteroidetes,2FM07@200643|Bacteroidia,22U20@171550|Rikenellaceae 976|Bacteroidetes E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_851899_2 1232410.KI421413_gene685 1.03e-30 112.0 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,42SJP@68525|delta/epsilon subdivisions,2WPK0@28221|Deltaproteobacteria,43SIP@69541|Desulfuromonadales 28221|Deltaproteobacteria K ATP cone domain nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_1008204_1 1121472.AQWN01000014_gene636 1.16e-24 102.0 COG0517@1|root,COG0517@2|Bacteria,1V0XU@1239|Firmicutes,24I2P@186801|Clostridia,261WS@186807|Peptococcaceae 186801|Clostridia S PFAM CBS domain acuB - - ko:K04767 - - - - ko00000 - - - ACT,CBS k59_1008204_2 2880.D8LFP9 3.92e-08 55.5 COG0126@1|root,KOG1367@2759|Eukaryota 2759|Eukaryota G phosphoglycerate kinase activity - - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_1582717_1 1158345.JNLL01000001_gene991 6.83e-57 194.0 COG0154@1|root,COG0154@2|Bacteria,2G3JX@200783|Aquificae 200783|Aquificae J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1582717_2 404589.Anae109_4339 2.12e-11 61.2 COG0721@1|root,COG0721@2|Bacteria,1QE6H@1224|Proteobacteria,42VPR@68525|delta/epsilon subdivisions,2WRP0@28221|Deltaproteobacteria,2YW6Q@29|Myxococcales 28221|Deltaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - iAF987.Gmet_0076 Glu-tRNAGln k59_488805_1 1167006.UWK_00814 1.3e-47 165.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,42PZJ@68525|delta/epsilon subdivisions,2WMGB@28221|Deltaproteobacteria,2MNPX@213118|Desulfobacterales 28221|Deltaproteobacteria E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 k59_121550_1 864069.MicloDRAFT_00038030 2.64e-48 174.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,1JSYN@119045|Methylobacteriaceae 28211|Alphaproteobacteria T PFAM Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - Guanylate_cyc k59_538377_1 1041139.KB902735_gene5983 1.03e-64 215.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9US@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc,Trans_reg_C k59_1274846_1 394.NGR_c28810 1.62e-13 77.4 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,4B81Q@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - AAA_16,DZR,Guanylate_cyc,TPR_12 k59_121560_1 1432050.IE4771_CH03224 2.79e-06 56.6 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2UPNC@28211|Alphaproteobacteria,4BARS@82115|Rhizobiaceae 28211|Alphaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_852232_1 1121918.ARWE01000001_gene3503 1.29e-50 169.0 COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,42NQ3@68525|delta/epsilon subdivisions,2X8MJ@28221|Deltaproteobacteria,43TMS@69541|Desulfuromonadales 28221|Deltaproteobacteria C Domain of unknown function (DUF4405) - - - - - - - - - - - - Ni_hydr_CYTB k59_1220562_1 395493.BegalDRAFT_3092 3.29e-114 347.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,460A8@72273|Thiotrichales 72273|Thiotrichales NU Secretion system protein - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_121561_1 439496.RBY4I_3115 1.31e-93 281.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TTC8@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit mtkB - 6.2.1.5,6.2.1.9 ko:K01902,ko:K08692 ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00346,M00374,M00620 R00405,R01256,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_1320367_2 1122221.JHVI01000013_gene2799 1.49e-31 119.0 COG3823@1|root,COG3823@2|Bacteria 2|Bacteria O gene silencing by RNA - - 2.3.2.5 ko:K00683 - - - - ko00000,ko01000 - - - Glu_cyclase_2 k59_121564_1 1278309.KB907099_gene2469 1.42e-12 73.9 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XHGD@135619|Oceanospirillales 135619|Oceanospirillales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_9 k59_1429079_2 1131266.ARWQ01000001_gene1280 4.22e-38 132.0 COG1881@1|root,arCOG04702@2157|Archaea,41T4M@651137|Thaumarchaeota 651137|Thaumarchaeota S Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_648032_2 380394.Lferr_2191 6.11e-38 134.0 COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,2NCVQ@225057|Acidithiobacillales 225057|Acidithiobacillales H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC k59_73366_1 1166018.FAES_3612 7.2e-24 103.0 28M5H@1|root,2ZAJ9@2|Bacteria,4NESS@976|Bacteroidetes,47NNA@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1374433_2 994573.T472_0214625 2.69e-44 155.0 COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,36DHM@31979|Clostridiaceae 186801|Clostridia J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_590853_1 765912.Thimo_2870 9.73e-32 117.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1WW17@135613|Chromatiales 135613|Chromatiales J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_590853_2 1232683.ADIMK_3613 1.67e-43 145.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,1S22R@1236|Gammaproteobacteria,466G4@72275|Alteromonadaceae 1236|Gammaproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_278003_2 204669.Acid345_1672 2.05e-57 201.0 COG0840@1|root,COG2972@1|root,COG0840@2|Bacteria,COG2972@2|Bacteria,3Y6CU@57723|Acidobacteria 57723|Acidobacteria T Tar ligand binding domain homologue - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,MCPsignal k59_73372_1 765914.ThisiDRAFT_0763 9.67e-159 468.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1320374_1 323848.Nmul_A0818 6.68e-31 119.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VHX2@28216|Betaproteobacteria,371PJ@32003|Nitrosomonadales 28216|Betaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_648047_2 886293.Sinac_6687 3.1e-44 151.0 2BGX2@1|root,32AX0@2|Bacteria,2J32R@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - k59_434545_1 485913.Krac_11720 1.12e-16 84.0 COG1102@1|root,COG1102@2|Bacteria 2|Bacteria F Psort location Cytoplasmic, score - - 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin2 k59_1429108_1 1120953.AUBH01000001_gene720 2.47e-12 72.4 COG1228@1|root,COG1228@2|Bacteria,1R500@1224|Proteobacteria,1RZG5@1236|Gammaproteobacteria,469NX@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_590864_1 268746.Q58MM5_BPPRM 4e-122 369.0 4QAZ6@10239|Viruses,4QUU8@35237|dsDNA viruses no RNA stage,4QPHV@28883|Caudovirales,4QI4H@10662|Myoviridae 10662|Myoviridae S Phage tail sheath protein - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098027 - - - - - - - - - - - k59_73395_1 1305737.JAFX01000001_gene1895 2.8e-32 122.0 COG2802@1|root,COG2802@2|Bacteria,4NEJU@976|Bacteroidetes,47NJ0@768503|Cytophagia 976|Bacteroidetes S Peptidase S16, lon domain protein - - 3.4.21.53 ko:K01338,ko:K07157 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - LON_substr_bdg k59_852263_1 494419.ALPM01000036_gene3186 1.62e-25 105.0 COG0842@1|root,COG0842@2|Bacteria,2GMXR@201174|Actinobacteria,1W8DM@1268|Micrococcaceae 201174|Actinobacteria V Transport permease protein - - - ko:K09694 ko02010,map02010 M00252 - - ko00000,ko00001,ko00002,ko02000 3.A.1.102 - - ABC2_membrane k59_852263_2 1184607.AUCHE_24_00230 5.51e-17 82.4 COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4F7F0@85018|Dermatophilaceae 201174|Actinobacteria V AAA domain, putative AbiEii toxin, Type IV TA system nodI - - ko:K09695 ko02010,map02010 M00252 - - ko00000,ko00001,ko00002,ko02000 3.A.1.102 - - ABC_tran k59_1429110_1 436308.Nmar_1201 1.35e-108 348.0 arCOG08777@1|root,arCOG08647@2157|Archaea,41SNX@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_590868_2 861299.J421_3601 1.55e-51 176.0 COG1260@1|root,COG1260@2|Bacteria,1ZT2X@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth,NAD_binding_5 k59_1583086_1 643867.Ftrac_3241 7.3e-73 236.0 COG0018@1|root,COG0018@2|Bacteria,4NE7Q@976|Bacteroidetes,47K91@768503|Cytophagia 976|Bacteroidetes J Arginyl-tRNA synthetase argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_73406_1 1205683.CAKR01000005_gene513 1.88e-63 208.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,41F7N@629|Yersinia 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF GO:0000166,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0010181,GO:0015980,GO:0016020,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0050662,GO:0051287,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_121609_2 1116472.MGMO_111c00200 1.12e-28 114.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1RNPS@1236|Gammaproteobacteria,1XE2X@135618|Methylococcales 135618|Methylococcales M (Lipo)protein - - - ko:K04754 - - - - ko00000 - - - MlaA k59_1320390_1 1283300.ATXB01000001_gene1309 1.43e-72 240.0 COG4191@1|root,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,1RQ5N@1236|Gammaproteobacteria,1XFZY@135618|Methylococcales 135618|Methylococcales T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - HATPase_c k59_1113617_1 1173024.KI912149_gene5161 2.81e-32 130.0 COG2265@1|root,COG2265@2|Bacteria,1G0MN@1117|Cyanobacteria,1JHCX@1189|Stigonemataceae 1117|Cyanobacteria J tRNA (Uracil-5-)-methyltransferase rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_805115_1 439235.Dalk_2170 4.25e-50 180.0 COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria,2MJFK@213118|Desulfobacterales 28221|Deltaproteobacteria M Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8 k59_1274916_1 322710.Avin_33130 2.86e-31 126.0 COG2109@1|root,COG4206@1|root,COG2109@2|Bacteria,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB btuB GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015267,GO:0015318,GO:0015889,GO:0015893,GO:0016020,GO:0016021,GO:0019904,GO:0022803,GO:0022838,GO:0022857,GO:0031224,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705 - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - iECB_1328.ECB_03851,iECP_1309.ECP_4183,iSF_1195.SF4048,iS_1188.S3696 Plug,TonB_dep_Rec k59_383804_2 472759.Nhal_2041 1.69e-83 253.0 COG2304@1|root,COG2304@2|Bacteria,1RA4S@1224|Proteobacteria,1RZNI@1236|Gammaproteobacteria,1WWII@135613|Chromatiales 135613|Chromatiales S oxidoreductase activity - - - - - - - - - - - - - k59_1636914_1 595537.Varpa_4925 4.41e-20 94.0 COG4122@1|root,COG4122@2|Bacteria,1QWCT@1224|Proteobacteria,2VJBK@28216|Betaproteobacteria,4ACMD@80864|Comamonadaceae 28216|Betaproteobacteria S O-methyltransferase activity - - - - - - - - - - - - - k59_1220631_1 1082932.ATCR1_06256 7.96e-22 98.6 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,2TRF9@28211|Alphaproteobacteria,4B98B@82115|Rhizobiaceae 28211|Alphaproteobacteria P Phosphate yjbB - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_747456_1 1089550.ATTH01000001_gene2545 4.27e-54 184.0 COG1115@1|root,COG1115@2|Bacteria,4NDX7@976|Bacteroidetes,1FIXE@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Sodium:alanine symporter family - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_330537_1 1123518.ARWI01000001_gene1948 6.8e-22 94.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,4601B@72273|Thiotrichales 72273|Thiotrichales EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_648093_1 1229909.NSED_01090 7.67e-79 247.0 COG0124@1|root,arCOG00404@2157|Archaea,41S9T@651137|Thaumarchaeota 651137|Thaumarchaeota J histidyl-tRNA synthetase - - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_648093_2 436308.Nmar_0237 5.05e-16 74.7 COG1976@1|root,arCOG04176@2157|Archaea,41SIP@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex eif6 - - ko:K03264 ko03008,map03008 - - - ko00000,ko00001,ko03009,ko03012 - - - eIF-6 k59_489265_1 1279009.ADICEAN_02870 3.69e-11 65.5 COG0300@1|root,COG0300@2|Bacteria,4PP7H@976|Bacteroidetes,47YIM@768503|Cytophagia 976|Bacteroidetes S Enoyl-(Acyl carrier protein) reductase - - 1.1.1.320 ko:K16216 - - - - ko00000,ko01000 - - - adh_short k59_489265_2 1150864.MILUP08_46575 3.37e-21 93.2 COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,4D9HB@85008|Micromonosporales 201174|Actinobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_1113631_1 83406.HDN1F_31650 0.000232 46.6 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4Q2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains fleR - - ko:K10943 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_648094_2 1122611.KB903991_gene7284 2.41e-43 153.0 COG0665@1|root,COG0665@2|Bacteria,2HFWH@201174|Actinobacteria,4EPWJ@85012|Streptosporangiales 201174|Actinobacteria E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_489275_1 1219077.VAZ01S_016_00520 9.67e-26 109.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1XTCT@135623|Vibrionales 135623|Vibrionales V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0042802,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702 - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_805145_1 477184.KYC_21561 2.36e-100 306.0 COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2VI8J@28216|Betaproteobacteria 28216|Betaproteobacteria C PFAM FAD linked oxidase domain protein - - - - - - - - - - - - BBE,FAD_binding_4 k59_1636922_2 41431.PCC8801_0524 5.79e-13 74.7 COG2199@1|root,COG3706@2|Bacteria,1G5BB@1117|Cyanobacteria,3KGBC@43988|Cyanothece 1117|Cyanobacteria T PFAM GGDEF domain containing protein - - - - - - - - - - - - GGDEF k59_648106_1 338966.Ppro_3618 1.37e-10 62.4 COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,42M6U@68525|delta/epsilon subdivisions,2WJ6Y@28221|Deltaproteobacteria,43UE4@69541|Desulfuromonadales 28221|Deltaproteobacteria H Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnC - 1.21.98.1 ko:K11784 ko00130,ko01110,map00130,map01110 - R08588 RC02329 ko00000,ko00001,ko01000 - - - Radical_SAM k59_648106_2 289376.THEYE_A1751 9.62e-13 73.6 COG1427@1|root,COG1427@2|Bacteria 2|Bacteria E Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnA - 1.21.98.1,4.2.1.151 ko:K07081,ko:K11782,ko:K11784 ko00130,ko01110,map00130,map01110 - R08588,R10666 RC02329,RC03232 ko00000,ko00001,ko01000 - - - VitK2_biosynth k59_805149_1 604331.AUHY01000017_gene2280 1.28e-07 60.1 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding ycf48 - - - - - - - - - - - BNR,PSII_BNR k59_1274952_1 314278.NB231_00630 8.58e-29 119.0 COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,1RMCR@1236|Gammaproteobacteria,1WXCQ@135613|Chromatiales 135613|Chromatiales P PFAM NnrS family protein - - - ko:K07234 - - - - ko00000 - - - NnrS k59_697370_1 65497.JODV01000004_gene1567 5.13e-06 48.5 COG0609@1|root,COG0609@2|Bacteria,2GK8Z@201174|Actinobacteria,4E0A1@85010|Pseudonocardiales 201174|Actinobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_697370_2 47763.JNZA01000011_gene6760 6.91e-07 55.1 COG1136@1|root,COG1136@2|Bacteria,2GJQV@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1061686_1 317025.Tcr_2167 2.25e-13 69.7 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,460AE@72273|Thiotrichales 72273|Thiotrichales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1061686_2 553385.JEMF01000037_gene2712 2.52e-37 132.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1XK2G@135619|Oceanospirillales 135619|Oceanospirillales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_852307_1 292415.Tbd_0119 3.55e-36 138.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2VH32@28216|Betaproteobacteria,1KRF5@119069|Hydrogenophilales 119069|Hydrogenophilales M Glycosyltransferase family 28 N-terminal domain - - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_648112_1 1304275.C41B8_16934 2.43e-15 72.0 COG0818@1|root,COG0818@2|Bacteria,1QJH1@1224|Proteobacteria,1SBNJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Prokaryotic diacylglycerol kinase - - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar k59_648112_2 679937.Bcop_0652 0.000426 44.7 COG1011@1|root,COG1011@2|Bacteria,4NM66@976|Bacteroidetes,2FMM5@200643|Bacteroidia,4ANU1@815|Bacteroidaceae 976|Bacteroidetes S HAD hydrolase, TIGR02254 family yjjG - - ko:K07025 - - - - ko00000 - - - HAD_2 k59_747474_2 367299.JOEE01000003_gene2921 3.21e-52 181.0 COG1982@1|root,COG1982@2|Bacteria,2GJ31@201174|Actinobacteria,4FJ0J@85021|Intrasporangiaceae 201174|Actinobacteria E Orn/Lys/Arg decarboxylase, C-terminal domain - - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - OKR_DC_1,OKR_DC_1_C k59_911426_1 1002340.AFCF01000052_gene1591 1.25e-73 239.0 COG5598@1|root,COG5598@2|Bacteria,1N18H@1224|Proteobacteria,2V98Z@28211|Alphaproteobacteria,34G83@302485|Phaeobacter 28211|Alphaproteobacteria H Trimethylamine methyltransferase (MTTB) - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB k59_656975_1 1122244.AUGF01000036_gene1120 9.14e-05 43.9 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,3NIQ4@468|Moraxellaceae 1236|Gammaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033817,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b1095,iAPECO1_1312.APECO1_176,iB21_1397.B21_01099,iBWG_1329.BWG_0943,iE2348C_1286.E2348C_1187,iEC042_1314.EC042_1165,iEC55989_1330.EC55989_1207,iECABU_c1320.ECABU_c13085,iECBD_1354.ECBD_2506,iECB_1328.ECB_01091,iECDH10B_1368.ECDH10B_1167,iECDH1ME8569_1439.ECDH1ME8569_1030,iECD_1391.ECD_01091,iECED1_1282.ECED1_1238,iECH74115_1262.ECH74115_1474,iECIAI1_1343.ECIAI1_1130,iECIAI39_1322.ECIAI39_2066,iECO103_1326.ECO103_1140,iECO111_1330.ECO111_1372,iECO26_1355.ECO26_1428,iECOK1_1307.ECOK1_1202,iECP_1309.ECP_1087,iECS88_1305.ECS88_1109,iECSE_1348.ECSE_1159,iECSF_1327.ECSF_0994,iECSP_1301.ECSP_1396,iECUMN_1333.ECUMN_1270,iECW_1372.ECW_m1203,iECs_1301.ECs1473,iEKO11_1354.EKO11_2739,iETEC_1333.ETEC_1160,iEcDH1_1363.EcDH1_2552,iEcE24377_1341.EcE24377A_1216,iEcSMS35_1347.EcSMS35_2032,iG2583_1286.G2583_1355,iJO1366.b1095,iJR904.b1095,iLF82_1304.LF82_0607,iNRG857_1313.NRG857_05280,iSF_1195.SF1099,iSFxv_1172.SFxv_1251,iS_1188.S1179,iUMN146_1321.UM146_11850,iWFL_1372.ECW_m1203,iY75_1357.Y75_RS05720,iZ_1308.Z1734,ic_1306.c1365 Ketoacyl-synt_C,ketoacyl-synt k59_656975_2 339671.Asuc_1580 4.98e-24 98.2 COG0698@1|root,COG0698@2|Bacteria,1RHBF@1224|Proteobacteria,1S58E@1236|Gammaproteobacteria,1Y8PU@135625|Pasteurellales 135625|Pasteurellales G Ribose 5-phosphate isomerase - - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_336978_1 1005048.CFU_1267 1.8e-23 97.1 COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2VHHT@28216|Betaproteobacteria,47356@75682|Oxalobacteraceae 28216|Betaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_336978_2 765914.ThisiDRAFT_0208 1.25e-86 264.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1WWXU@135613|Chromatiales 135613|Chromatiales EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_1283988_1 1122915.AUGY01000001_gene7258 3.51e-28 121.0 COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,4HA63@91061|Bacilli,26QXC@186822|Paenibacillaceae 91061|Bacilli L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1168928_1 1434929.X946_607 1.01e-27 110.0 COG0500@1|root,COG2226@2|Bacteria,1MW7J@1224|Proteobacteria,2VR1M@28216|Betaproteobacteria,1KG7H@119060|Burkholderiaceae 28216|Betaproteobacteria Q Dimerisation domain - - - - - - - - - - - - Dimerisation2,Methyltransf_2 k59_175985_1 247633.GP2143_07249 2.58e-19 89.7 2C852@1|root,32YB2@2|Bacteria,1N9HY@1224|Proteobacteria,1SCRT@1236|Gammaproteobacteria,1J6SR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4136) - - - - - - - - - - - - DUF4136 k59_1644799_1 713586.KB900536_gene392 1.01e-13 70.1 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1WWFM@135613|Chromatiales 135613|Chromatiales E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_1644799_2 187272.Mlg_1887 3.49e-61 192.0 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1WY2N@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_597525_1 292459.STH2840 6.13e-29 105.0 COG0724@1|root,COG0724@2|Bacteria,1VBMH@1239|Firmicutes,24NVR@186801|Clostridia 186801|Clostridia S Rna-binding protein - - - - - - - - - - - - RRM_1 k59_597525_2 1282356.H045_00645 3.04e-24 98.6 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria,1YPJ1@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria G peptidyl-prolyl cis-trans isomerase slyD GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010467,GO:0016151,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022417,GO:0031647,GO:0035821,GO:0036211,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043963,GO:0044003,GO:0044068,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044501,GO:0046872,GO:0046914,GO:0050821,GO:0050896,GO:0050897,GO:0051082,GO:0051604,GO:0051701,GO:0051704,GO:0051817,GO:0052027,GO:0052250,GO:0065007,GO:0065008,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_597525_3 740709.A10D4_11019 1.52e-85 259.0 COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,1RR4R@1236|Gammaproteobacteria,2QFX2@267893|Idiomarinaceae 1236|Gammaproteobacteria S hemolysin III yqfA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII k59_597526_1 1244869.H261_08693 4.23e-83 266.0 COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,2JP9C@204441|Rhodospirillales 204441|Rhodospirillales I Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_498173_1 1397666.RS24_01364 1.08e-35 135.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1644818_1 331869.BAL199_29490 4.19e-23 93.6 COG3917@1|root,COG3917@2|Bacteria,1RDNQ@1224|Proteobacteria,2VGB4@28211|Alphaproteobacteria,4BTB1@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q DSBA-like thioredoxin domain - - - - - - - - - - - - DSBA k59_1644818_2 999541.bgla_2g15400 2.06e-51 177.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VI77@28216|Betaproteobacteria,1K003@119060|Burkholderiaceae 28216|Betaproteobacteria I carboxylase accB - 6.4.1.4 ko:K01969 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1228518_1 1122604.JONR01000006_gene2723 2.13e-38 133.0 COG3631@1|root,COG3631@2|Bacteria,1N2V5@1224|Proteobacteria,1S93Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 k59_1228518_2 392499.Swit_2043 2.35e-38 134.0 2EJXJ@1|root,33DN7@2|Bacteria,1NTE4@1224|Proteobacteria,2UQUZ@28211|Alphaproteobacteria,2K9B7@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_442217_1 1192868.CAIU01000015_gene1972 1.25e-23 94.7 COG1522@1|root,COG1522@2|Bacteria,1RD8W@1224|Proteobacteria,2U4RV@28211|Alphaproteobacteria,43R56@69277|Phyllobacteriaceae 28211|Alphaproteobacteria K helix_turn_helix ASNC type - - - - - - - - - - - - AsnC_trans_reg,HTH_24 k59_442217_2 1380394.JADL01000008_gene3611 4.31e-14 72.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2TSZ9@28211|Alphaproteobacteria,2JQNV@204441|Rhodospirillales 204441|Rhodospirillales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_N k59_754079_1 1348635.BBJY01000008_gene1698 6.86e-65 213.0 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1XUTK@135623|Vibrionales 135623|Vibrionales M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella - - - - - - - - - - - - SBP_bac_3,SLT k59_498191_2 768671.ThimaDRAFT_0289 2.72e-54 189.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1WWY6@135613|Chromatiales 135613|Chromatiales U Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 k59_1530812_1 522373.Smlt1521 3.78e-07 58.2 COG0475@1|root,COG0475@2|Bacteria,1MVGV@1224|Proteobacteria,1S1ET@1236|Gammaproteobacteria,1X3J6@135614|Xanthomonadales 135614|Xanthomonadales P Sodium hydrogen exchanger - - - - - - - - - - - - Na_H_Exchanger k59_82298_2 472759.Nhal_0920 1.15e-05 47.4 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,1WXRZ@135613|Chromatiales 135613|Chromatiales M PFAM AsmA family protein - - - ko:K07289 - - - - ko00000 - - - AsmA k59_962524_1 936455.KI421499_gene2353 8.67e-53 171.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2TRFE@28211|Alphaproteobacteria,3JSYS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3,1.6.99.3 ko:K00338,ko:K03941 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 - - Fer4 k59_962524_2 1112216.JH594425_gene2751 5.84e-06 47.8 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2TS09@28211|Alphaproteobacteria,2JZYY@204457|Sphingomonadales 204457|Sphingomonadales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_1491661_1 483219.LILAB_12745 2.58e-08 58.2 COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,42QV3@68525|delta/epsilon subdivisions,2WMT2@28221|Deltaproteobacteria,2YXDM@29|Myxococcales 28221|Deltaproteobacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH k59_1491661_2 272942.RCAP_rcc02135 6.26e-22 92.4 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria,1FB9Q@1060|Rhodobacter 28211|Alphaproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_176007_1 1051632.TPY_1815 7.98e-54 187.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups rfaG GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02844 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT4 iSDY_1059.SDY_4061 Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_231776_1 110319.CF8_0467 1.02e-99 312.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,4DPBE@85009|Propionibacteriales 201174|Actinobacteria C ferredoxin oxidoreductase korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_962529_1 1449065.JMLL01000011_gene2313 5.55e-69 214.0 COG3631@1|root,COG3631@2|Bacteria,1RGEA@1224|Proteobacteria,2U7YB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL k59_1168959_1 1167006.UWK_00394 4.47e-18 89.0 COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria,2MI6A@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg k59_911476_1 436308.Nmar_0280 2.72e-126 371.0 COG1005@1|root,arCOG01546@2157|Archaea,41SAT@651137|Thaumarchaeota 651137|Thaumarchaeota C NADH dehydrogenase - - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_390904_1 861299.J421_1833 1e-35 137.0 28P8D@1|root,32151@2|Bacteria,1ZU99@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Pfam:SusD - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD_RagB k59_703984_1 298386.PBPRB0645 7.51e-35 133.0 COG0348@1|root,COG0348@2|Bacteria,1N605@1224|Proteobacteria 1224|Proteobacteria C COG0348 Polyferredoxin vnfA - - - - - - - - - - - Fer4_5 k59_1491688_1 1049564.TevJSym_aa01810 2.52e-28 112.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J8SM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Citrate transporter sac1 - - - - - - - - - - - CitMHS,TrkA_C k59_129491_1 862965.PARA_03470 1.74e-61 211.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1Y6SS@135625|Pasteurellales 135625|Pasteurellales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_597576_1 1301098.PKB_5311 5.7e-33 126.0 COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria 1236|Gammaproteobacteria O carbamoyl transferase, NodU family HA62_32075 - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_597576_2 483219.LILAB_23000 6.87e-42 149.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria,2YXED@29|Myxococcales 28221|Deltaproteobacteria E Belongs to the aspartate-semialdehyde dehydrogenase family asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1284087_1 290402.Cbei_0654 1.5e-24 107.0 COG2199@1|root,COG3706@2|Bacteria,1V9Y7@1239|Firmicutes,24A8B@186801|Clostridia,36E8P@31979|Clostridiaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - AAA_16,GGDEF,Pkinase,TPR_12,TPR_8 k59_129505_1 1121861.KB899910_gene631 1.68e-07 54.3 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2TUKR@28211|Alphaproteobacteria,2JPMV@204441|Rhodospirillales 204441|Rhodospirillales H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_129505_2 627192.SLG_04410 5.68e-13 69.7 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2K1V6@204457|Sphingomonadales 204457|Sphingomonadales G PQQ-like domain - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_1120148_1 877420.ATVW01000002_gene1235 1.95e-07 56.6 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia,27J4E@186928|unclassified Lachnospiraceae 186801|Clostridia F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_82361_1 247490.KSU1_C0714 8.68e-24 104.0 COG1404@1|root,COG1404@2|Bacteria,2IZNN@203682|Planctomycetes 203682|Planctomycetes O alpha-L-arabinofuranosidase - - - - - - - - - - - - SBBP k59_1437938_1 1122217.KB899572_gene1141 3.41e-22 97.1 COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,4H32N@909932|Negativicutes 909932|Negativicutes J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA-synt_2d,tRNA_anti-codon k59_1437938_2 1232410.KI421426_gene1423 7.31e-08 53.5 COG2199@1|root,COG3706@2|Bacteria,1PFC9@1224|Proteobacteria,4345Y@68525|delta/epsilon subdivisions,2X1UV@28221|Deltaproteobacteria,43V8B@69541|Desulfuromonadales 28221|Deltaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,HAMP k59_1168991_1 1254432.SCE1572_31185 1.69e-71 239.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42Z54@68525|delta/epsilon subdivisions,2WUB9@28221|Deltaproteobacteria,2YYC4@29|Myxococcales 28221|Deltaproteobacteria J Anticodon-binding domain of tRNA valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_962569_1 1281779.H009_20861 8.93e-25 102.0 COG1011@1|root,COG1011@2|Bacteria,1MVF8@1224|Proteobacteria,2UN02@28211|Alphaproteobacteria,4BHY4@82115|Rhizobiaceae 28211|Alphaproteobacteria E HAD-hyrolase-like - - - ko:K07025 - - - - ko00000 - - - HAD_2 k59_962569_2 1487923.DP73_18475 6.94e-19 83.6 COG2128@1|root,COG2128@2|Bacteria,1VQME@1239|Firmicutes,24V56@186801|Clostridia 186801|Clostridia S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_1068253_1 1005395.CSV86_12920 2.11e-23 99.4 COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,1YX8T@136845|Pseudomonas putida group 1236|Gammaproteobacteria P Sodium hydrogen exchanger nhaP - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger k59_1015374_1 1280948.HY36_01145 3.6e-100 318.0 COG1629@1|root,COG4771@2|Bacteria,1N6JG@1224|Proteobacteria,2TSK9@28211|Alphaproteobacteria,43WCB@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Outer membrane receptor - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec k59_390934_1 436308.Nmar_1794 7.29e-91 293.0 COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC - 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - PolC_DP2 k59_859106_1 330214.NIDE3491 6.67e-64 210.0 COG1538@1|root,COG1538@2|Bacteria,3J0N2@40117|Nitrospirae 40117|Nitrospirae M Evidence 2b Function of strongly homologous gene - - - ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 - - OEP k59_859106_2 43989.cce_1643 2.5e-20 87.0 COG0778@1|root,COG0778@2|Bacteria,1G42X@1117|Cyanobacteria,3KJXS@43988|Cyanothece 1117|Cyanobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_859108_1 1354722.JQLS01000004_gene4234 1.31e-56 186.0 COG1024@1|root,COG1024@2|Bacteria,1MXEN@1224|Proteobacteria,2TTIH@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 k59_859108_2 208444.JNYY01000005_gene6582 1.97e-17 83.2 COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4DZSF@85010|Pseudonocardiales 201174|Actinobacteria I Methylmalonyl-CoA mutase mcmA2a - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_1068263_1 1461694.ATO9_12480 4.44e-87 291.0 COG0771@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2V8V8@28211|Alphaproteobacteria,2PFGF@252301|Oceanicola 28211|Alphaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - - k59_1589950_1 509191.AEDB02000019_gene4509 4.77e-22 94.4 2E13Z@1|root,32WJ8@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_284762_1 1234595.C725_2932 1.08e-33 129.0 COG0189@1|root,COG0189@2|Bacteria,1NJD7@1224|Proteobacteria 1224|Proteobacteria HJ ligase activity - - - - - - - - - - - - RimK k59_390943_2 1453501.JELR01000002_gene347 2.13e-17 78.2 2EQ5T@1|root,32ZV0@2|Bacteria,1NFTI@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_390943_3 1232410.KI421425_gene1548 1.75e-22 92.4 COG0457@1|root,COG0457@2|Bacteria,1N1J2@1224|Proteobacteria,42ZHG@68525|delta/epsilon subdivisions,2WV2W@28221|Deltaproteobacteria,43UR6@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_911532_1 1121405.dsmv_1318 1.62e-77 248.0 COG0686@1|root,COG0686@2|Bacteria,1MXDG@1224|Proteobacteria,4318C@68525|delta/epsilon subdivisions,2WWVN@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Alanine dehydrogenase/PNT, N-terminal domain - - 1.5.1.7,1.5.1.8,1.5.1.9 ko:K00290,ko:K14157 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715,R00716,R02313 RC00215,RC00217,RC00225,RC01532 ko00000,ko00001,ko00002,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_598147_1 472759.Nhal_2291 2.15e-84 267.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1WWYU@135613|Chromatiales 135613|Chromatiales P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3333 k59_1645632_1 28532.XP_010528252.1 1.34e-27 113.0 COG0265@1|root,KOG1320@2759|Eukaryota,37NI3@33090|Viridiplantae,3G8QG@35493|Streptophyta,3HT3Z@3699|Brassicales 35493|Streptophyta O Protease Do-like 1, chloroplastic - GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006091,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0009719,GO:0009725,GO:0009735,GO:0009765,GO:0009987,GO:0010033,GO:0010206,GO:0015979,GO:0016020,GO:0016787,GO:0017171,GO:0019538,GO:0019684,GO:0030091,GO:0030163,GO:0031976,GO:0031977,GO:0031984,GO:0034357,GO:0042221,GO:0042651,GO:0042802,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0055035,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - PDZ_2,Trypsin_2 k59_1645632_2 330214.NIDE0953 7.41e-48 155.0 COG0432@1|root,COG0432@2|Bacteria 2|Bacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_814890_1 1357714.A0A067XQ97_9CAUD 6.77e-27 108.0 4QHG7@10239|Viruses,4R0G1@35237|dsDNA viruses no RNA stage,4QRS2@28883|Caudovirales,4QJ56@10662|Myoviridae 10662|Myoviridae S exonuclease activity - - - - - - - - - - - - - k59_1015935_1 439235.Dalk_0206 2.82e-44 161.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,42PST@68525|delta/epsilon subdivisions,2WJ3A@28221|Deltaproteobacteria,2MIS5@213118|Desulfobacterales 28221|Deltaproteobacteria T Belongs to the PEP-utilizing enzyme family ptsP - 2.7.3.9 ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_814895_1 1379270.AUXF01000001_gene2524 6.53e-34 135.0 COG0209@1|root,COG0209@2|Bacteria 2|Bacteria F ribonucleoside-diphosphate reductase activity rtpR - 1.1.98.6,1.17.4.1 ko:K00525,ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024,R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC k59_1169449_1 358823.DF19_29865 1.45e-61 207.0 COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria 201174|Actinobacteria IQ synthetase fadD19 - 6.2.1.42 ko:K18688 - - - - ko00000,ko01000 - - - AMP-binding,AMP-binding_C k59_598166_2 1304885.AUEY01000050_gene1209 4.86e-73 222.0 COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,42SI7@68525|delta/epsilon subdivisions,2WPSJ@28221|Deltaproteobacteria,2MKCA@213118|Desulfobacterales 28221|Deltaproteobacteria S Uncharacterized BCR, YaiI/YqxD family COG1671 yaiI - - ko:K09768 - - - - ko00000 - - - DUF188 k59_545370_1 652103.Rpdx1_1504 5.26e-50 177.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,3JVBN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N k59_344703_2 330214.NIDE4136 3.92e-94 284.0 COG0115@1|root,COG0115@2|Bacteria 2|Bacteria E branched-chain-amino-acid transaminase activity dat GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046416,GO:0046437,GO:0047810,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 k59_666124_1 1121406.JAEX01000003_gene1501 2.33e-15 80.1 COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2M7W7@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM Extracellular ligand-binding receptor livK-1 - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - iAF987.Gmet_1823 Peripla_BP_6 k59_1596143_1 358220.C380_12960 2.36e-35 136.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria 28216|Betaproteobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,cNMP_binding k59_1076052_1 1469245.JFBG01000036_gene1974 7.18e-55 186.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGB@1236|Gammaproteobacteria,1X1MI@135613|Chromatiales 135613|Chromatiales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_1386621_1 497964.CfE428DRAFT_1691 4.32e-100 300.0 COG0524@1|root,COG0524@2|Bacteria,46U0Y@74201|Verrucomicrobia 74201|Verrucomicrobia G pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB k59_450488_1 1458275.AZ34_07525 5.48e-61 197.0 COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,2VIZ9@28216|Betaproteobacteria,4AARP@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1365) - - - ko:K09701 - - - - ko00000 - - - DUF1365 k59_919587_1 1379270.AUXF01000003_gene3405 1.49e-28 113.0 COG4974@1|root,COG4974@2|Bacteria,1ZT3T@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Phage integrase, N-terminal SAM-like domain xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_1500644_1 96561.Dole_0341 1.74e-86 271.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2MHTP@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1276 CTP_synth_N,GATase k59_1445186_2 1260251.SPISAL_08215 1.06e-87 271.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1WW22@135613|Chromatiales 135613|Chromatiales K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_238416_1 500635.MITSMUL_03765 8.42e-32 122.0 COG1561@1|root,COG1561@2|Bacteria,1TQHJ@1239|Firmicutes,4H2DA@909932|Negativicutes 909932|Negativicutes S TIGR00255 family - - - - - - - - - - - - DUF1732,YicC_N k59_969118_1 1041159.AZUW01000018_gene795 1.09e-07 54.7 COG2010@1|root,COG2010@2|Bacteria,1RGXM@1224|Proteobacteria,2U95Y@28211|Alphaproteobacteria,4BJVW@82115|Rhizobiaceae 28211|Alphaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III cytC - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_969118_2 998674.ATTE01000001_gene4226 3.05e-81 249.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,4607J@72273|Thiotrichales 72273|Thiotrichales F phosphoribosylaminoimidazole-succinocarboxamide synthase purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_507266_1 1120972.AUMH01000001_gene1028 7.38e-38 137.0 COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,4HC7T@91061|Bacilli,27839@186823|Alicyclobacillaceae 91061|Bacilli E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_710496_2 765910.MARPU_08680 1.32e-36 139.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1WWEF@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_1653911_1 765910.MARPU_11735 4.61e-63 213.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1WXQ0@135613|Chromatiales 135613|Chromatiales P Citrate transporter - - - - - - - - - - - - CitMHS,TrkA_C k59_1653911_2 1283300.ATXB01000001_gene1992 2.9e-59 196.0 COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1XDJP@135618|Methylococcales 135618|Methylococcales S PFAM Cytochrome c assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_969127_2 391625.PPSIR1_27413 7.69e-32 124.0 COG0477@1|root,COG2814@2|Bacteria,1RB5E@1224|Proteobacteria,42MD8@68525|delta/epsilon subdivisions,2WMJV@28221|Deltaproteobacteria 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,MFS_1_like,MFS_3,Sugar_tr k59_450513_1 1121405.dsmv_2683 4.4e-19 91.3 28H91@1|root,2Z7KU@2|Bacteria,1R4NB@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_91240_2 566466.NOR53_250 9.71e-34 132.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1J57U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU secretory pathway xpsE GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_603847_1 1131553.JIBI01000012_gene823 1.34e-66 220.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,2VMUK@28216|Betaproteobacteria,372K1@32003|Nitrosomonadales 28216|Betaproteobacteria O NfeD-like C-terminal, partner-binding nfeD - - ko:K07403 - - - - ko00000 - - - NfeD k59_666182_1 1031711.RSPO_c01795 6.41e-77 261.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,1JZX3@119060|Burkholderiaceae 28216|Betaproteobacteria I 3-hydroxyacyl-coa dehydrogenase fadB - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_292604_1 379066.GAU_2431 1.08e-94 288.0 COG0626@1|root,COG0626@2|Bacteria,1ZT9F@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Cys/Met metabolism PLP-dependent enzyme - - 4.4.1.1 ko:K01758 ko00260,ko00270,ko00450,ko01100,ko01130,ko01230,map00260,map00270,map00450,map01100,map01130,map01230 M00338 R00782,R01001,R02408,R04770,R04930,R09366 RC00056,RC00069,RC00348,RC00382,RC00710,RC01209,RC01210,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP k59_823276_1 1122925.KB895376_gene669 1.97e-07 54.7 COG0664@1|root,COG0664@2|Bacteria,1V5MZ@1239|Firmicutes,4HUY4@91061|Bacilli,26SDY@186822|Paenibacillaceae 91061|Bacilli K cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - ko:K21562 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1236806_1 1280953.HOC_18129 1.52e-78 244.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2TR4R@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit MA20_01040 - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_1653939_1 314278.NB231_11419 4.09e-27 114.0 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,1RP3U@1236|Gammaproteobacteria,1WZUN@135613|Chromatiales 135613|Chromatiales L COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - ko:K06400 - - - - ko00000 - - - Recombinase,Resolvase,Zn_ribbon_recom k59_1445213_1 338963.Pcar_1673 3.09e-05 51.2 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WJKC@28221|Deltaproteobacteria,43SVH@69541|Desulfuromonadales 28221|Deltaproteobacteria M tail specific protease ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_1021706_1 330214.NIDE1723 2.31e-14 69.3 COG0251@1|root,COG0251@2|Bacteria,3J144@40117|Nitrospirae 40117|Nitrospirae J Endoribonuclease L-PSP - - - - - - - - - - - - YjgF_endoribonc k59_1021706_2 330214.NIDE1711 1.57e-29 116.0 COG1015@1|root,COG1015@2|Bacteria 2|Bacteria G phosphopentomutase activity deoB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008973,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - iLF82_1304.LF82_0465,iNRG857_1313.NRG857_22165 Metalloenzyme k59_551373_1 1131269.AQVV01000001_gene1469 2.07e-41 154.0 COG0457@1|root,COG1262@1|root,COG0457@2|Bacteria,COG1262@2|Bacteria 2|Bacteria T PFAM Formylglycine-generating sulfatase enzyme - - 1.14.99.50 ko:K18912 ko00340,map00340 - R11013 RC03323,RC03324 ko00000,ko00001,ko01000 - - - FGE-sulfatase,Pkinase k59_1653944_1 1047013.AQSP01000141_gene118 1.53e-07 58.2 COG0642@1|root,COG3292@1|root,COG3920@1|root,COG2205@2|Bacteria,COG3292@2|Bacteria,COG3920@2|Bacteria,2NNZT@2323|unclassified Bacteria 2|Bacteria T Two component regulator propeller pdtaS - 2.7.13.3 ko:K00936 - M00839 - - ko00000,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,Reg_prop k59_1331247_1 331869.BAL199_06324 4.38e-166 492.0 COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Methionine synthase metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_1293174_1 1123400.KB904763_gene2419 1.51e-140 412.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,45ZMR@72273|Thiotrichales 72273|Thiotrichales J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_1500698_1 1121422.AUMW01000023_gene2786 3.55e-14 70.9 COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,247NH@186801|Clostridia,2609G@186807|Peptococcaceae 186801|Clostridia J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_1237745_1 1123261.AXDW01000011_gene643 2.01e-78 255.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,1X4FN@135614|Xanthomonadales 135614|Xanthomonadales G Glucose dehydrogenase gcd2 - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 k59_92122_1 1279019.ARQK01000031_gene1195 8.98e-52 164.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,1WYJ2@135613|Chromatiales 135613|Chromatiales O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_92122_2 1122603.ATVI01000010_gene1069 0.000635 41.2 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1X3SN@135614|Xanthomonadales 135614|Xanthomonadales O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groEL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_138563_1 290397.Adeh_3594 4.74e-109 330.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2YUQN@29|Myxococcales 28221|Deltaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_138563_2 502025.Hoch_5366 4.78e-11 58.5 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,42U7E@68525|delta/epsilon subdivisions,2WPZP@28221|Deltaproteobacteria,2Z1SG@29|Myxococcales 28221|Deltaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_1501663_1 1502851.FG93_01074 1.36e-15 75.5 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2TSN3@28211|Alphaproteobacteria,3JS3B@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates mtnP - 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_1501663_2 580331.Thit_2157 9.36e-31 119.0 28IJ2@1|root,2Z8K1@2|Bacteria,1V11N@1239|Firmicutes,24ECE@186801|Clostridia,42EZM@68295|Thermoanaerobacterales 186801|Clostridia - - - - - - - - - - - - - - - k59_92137_1 706587.Desti_2560 3.12e-15 70.5 COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,42V07@68525|delta/epsilon subdivisions,2WRQ6@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_824316_1 1211115.ALIQ01000188_gene642 3.24e-44 167.0 COG3598@1|root,COG3598@2|Bacteria,1PVAP@1224|Proteobacteria,2V9QH@28211|Alphaproteobacteria,3NCJZ@45404|Beijerinckiaceae 28211|Alphaproteobacteria L AAA domain - - - - - - - - - - - - AAA_25 k59_1537221_1 330214.NIDE0853 7.02e-57 188.0 COG4105@1|root,COG4105@2|Bacteria,3J0UU@40117|Nitrospirae 40117|Nitrospirae S Tetratricopeptide repeat - - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_1175642_1 95619.PM1_0211830 9.62e-30 118.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945 BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_1175642_2 1122194.AUHU01000002_gene2847 1.1e-17 89.7 COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria,4673V@72275|Alteromonadaceae 1236|Gammaproteobacteria D Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins zipA GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - ko:K03528 - - - - ko00000,ko03036 - - - ZipA_C k59_138586_1 765910.MARPU_03425 8.17e-43 158.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1WWN6@135613|Chromatiales 135613|Chromatiales E Extracellular solute-binding protein, family 5 - - - - - - - - - - - - SBP_bac_5 k59_138586_2 314278.NB231_16068 1.46e-16 77.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,1WX1J@135613|Chromatiales 135613|Chromatiales I Enoyl- acyl-carrier-protein reductase NADH - - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_824332_2 1122217.KB899568_gene814 1.85e-36 130.0 COG1778@1|root,COG1778@2|Bacteria,1V5JJ@1239|Firmicutes,4H4ID@909932|Negativicutes 909932|Negativicutes S 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family kdsC - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 k59_182302_1 439481.Aboo_0245 2.16e-18 93.2 COG0438@1|root,arCOG01403@2157|Archaea 2157|Archaea M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1237802_2 96561.Dole_3056 9.23e-22 87.8 2E4RC@1|root,32ZJW@2|Bacteria,1N8RU@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_711264_1 1123487.KB892834_gene2733 1.66e-85 263.0 COG0657@1|root,COG0657@2|Bacteria,1N2XW@1224|Proteobacteria,2WEJK@28216|Betaproteobacteria,2KVW4@206389|Rhodocyclales 206389|Rhodocyclales I Carboxylesterase family - - - - - - - - - - - - Abhydrolase_3 k59_604486_1 292415.Tbd_1464 1.37e-61 202.0 COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,2VIGZ@28216|Betaproteobacteria,1KTA6@119069|Hydrogenophilales 119069|Hydrogenophilales M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_1022407_2 697282.Mettu_1066 1.49e-27 111.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,1XED7@135618|Methylococcales 135618|Methylococcales HJ PFAM ATP-grasp fold - - - - - - - - - - - - RLAN,RimK k59_451625_2 85643.Tmz1t_3476 3.78e-55 186.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2VJR5@28216|Betaproteobacteria,2KUCZ@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_1655068_1 220664.PFL_4843 9.95e-16 77.8 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1YPDD@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_92173_1 1121918.ARWE01000001_gene3102 5.51e-101 306.0 COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,42PNI@68525|delta/epsilon subdivisions,2WJNF@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PFAM natural resistance-associated macrophage protein mntH - - ko:K03322 - - - - ko00000,ko02000 2.A.55.2.6,2.A.55.3 - - Nramp,Usp k59_293497_1 455632.SGR_5203 1.03e-18 91.3 COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,41A7P@629295|Streptomyces griseus group 201174|Actinobacteria I Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_239244_1 338963.Pcar_0324 1.93e-76 243.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,43BJP@68525|delta/epsilon subdivisions,2WJWZ@28221|Deltaproteobacteria,43S0F@69541|Desulfuromonadales 28221|Deltaproteobacteria C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2,4.3.1.1 ko:K01679,ko:K01744 ko00020,ko00250,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00250,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R00490,R01082 RC00316,RC00443,RC02799 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_1537255_1 436308.Nmar_0353 1.33e-73 223.0 COG0195@1|root,arCOG01760@2157|Archaea,41SJQ@651137|Thaumarchaeota 651137|Thaumarchaeota K Participates in transcription termination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_2 k59_1655086_1 935548.KI912159_gene6452 7.5e-64 212.0 COG0747@1|root,COG0747@2|Bacteria,1MXQ4@1224|Proteobacteria,2TTIZ@28211|Alphaproteobacteria,43GY5@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E ABC-type dipeptide transport system periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1237840_1 1229909.NSED_09670 1.39e-76 243.0 COG0652@1|root,arCOG04767@2157|Archaea,41T0W@651137|Thaumarchaeota 651137|Thaumarchaeota O Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_866266_1 330214.NIDE3255 2.28e-113 355.0 COG0243@1|root,COG0243@2|Bacteria 2|Bacteria C molybdopterin cofactor binding ddhA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4 ko:K00370,ko:K10700,ko:K16964,ko:K17050 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_451650_1 1121104.AQXH01000001_gene1928 1.27e-105 329.0 COG0308@1|root,COG0308@2|Bacteria,4NGTZ@976|Bacteroidetes,1IRKM@117747|Sphingobacteriia 976|Bacteroidetes E Peptidase M1, membrane alanine aminopeptidase pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - ERAP1_C,Peptidase_M1 k59_14572_1 243231.GSU3259 1.15e-49 175.0 COG3005@1|root,COG3005@2|Bacteria,1R956@1224|Proteobacteria,42Q0X@68525|delta/epsilon subdivisions,2WMHI@28221|Deltaproteobacteria,43U0A@69541|Desulfuromonadales 28221|Deltaproteobacteria C NapC/NirT cytochrome c family, N-terminal region - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - - - - - - - - - - Cytochrom_NNT k59_1294253_1 203124.Tery_2827 6.15e-18 84.0 COG0534@1|root,COG0534@2|Bacteria,1G2M4@1117|Cyanobacteria,1H8IY@1150|Oscillatoriales 1117|Cyanobacteria V Mate efflux family protein - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_1084381_1 1459636.NTE_02155 2.67e-11 67.0 COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota 651137|Thaumarchaeota T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,dCache_1 k59_1084381_2 395493.BegalDRAFT_0738 2.34e-47 164.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,45ZZX@72273|Thiotrichales 72273|Thiotrichales T response regulator receiver - - - - - - - - - - - - DUF229,HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat k59_517531_1 1379698.RBG1_1C00001G0230 1.53e-52 184.0 COG2206@1|root,COG2206@2|Bacteria,2NPP4@2323|unclassified Bacteria 2|Bacteria T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD k59_610301_1 1123360.thalar_02883 5.97e-17 73.9 2ERCE@1|root,33IY3@2|Bacteria,1NNN9@1224|Proteobacteria,2UXY5@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_610301_2 1437824.BN940_02346 8.9e-22 89.4 COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,2VNRT@28216|Betaproteobacteria 28216|Betaproteobacteria C cytochrome c oxidase (Subunit II) - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2 k59_872438_2 1238182.C882_3937 2.5e-28 115.0 COG0841@1|root,COG0841@2|Bacteria,1R2RN@1224|Proteobacteria,2TZQG@28211|Alphaproteobacteria,2JZ4G@204441|Rhodospirillales 204441|Rhodospirillales V MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1084391_1 557599.MKAN_25710 6.32e-104 318.0 COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,234PM@1762|Mycobacteriaceae 201174|Actinobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1510999_3 757424.Hsero_3057 6.18e-33 125.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2VHFR@28216|Betaproteobacteria,473J2@75682|Oxalobacteraceae 28216|Betaproteobacteria C Cytochrome bd-type quinol oxidase, subunit 1 cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_1244339_2 658187.LDG_7605 3.5e-94 284.0 COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,1RZQU@1236|Gammaproteobacteria,1JDG6@118969|Legionellales 118969|Legionellales S Glucose-regulated metallo-peptidase M90 mtfA - - ko:K09933 - - - - ko00000,ko01002 - - - Peptidase_M90 k59_1244339_3 1123368.AUIS01000011_gene1190 6.16e-112 329.0 COG0842@1|root,COG0842@2|Bacteria,1N55T@1224|Proteobacteria,1S29T@1236|Gammaproteobacteria,2NCSV@225057|Acidithiobacillales 225057|Acidithiobacillales V ABC-2 type transporter - - - ko:K09694 ko02010,map02010 M00252 - - ko00000,ko00001,ko00002,ko02000 3.A.1.102 - - ABC2_membrane k59_1244339_4 948106.AWZT01000002_gene6303 5.16e-36 132.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VI3G@28216|Betaproteobacteria,1JZWV@119060|Burkholderiaceae 28216|Betaproteobacteria P Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction. Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide. This subunit is responsible for energy coupling to the transport system nodI - - ko:K01990,ko:K09695 ko02010,map02010 M00252,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.102 - - ABC_tran k59_1664328_1 996637.SGM_4297 1.63e-13 75.5 COG0029@1|root,COG0029@2|Bacteria,2I2IJ@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16,2.4.2.19 ko:K00278,ko:K00767 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481,R03348 RC00006,RC02566,RC02877 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1244340_1 1288494.EBAPG3_1320 5.58e-95 300.0 COG1205@1|root,COG1205@2|Bacteria,1QDCY@1224|Proteobacteria,2WA1A@28216|Betaproteobacteria,374J9@32003|Nitrosomonadales 28216|Betaproteobacteria L DEAD-like helicases superfamily - - - ko:K06877 - - - - ko00000 - - - DEAD k59_99536_1 1144275.COCOR_03152 9.79e-66 226.0 COG3391@1|root,COG3391@2|Bacteria,1R66T@1224|Proteobacteria,439FZ@68525|delta/epsilon subdivisions,2X4RS@28221|Deltaproteobacteria,2YZGC@29|Myxococcales 28221|Deltaproteobacteria G 6-phosphogluconolactonase activity - - - - - - - - - - - - - k59_1304682_1 388413.ALPR1_02210 1.02e-21 99.4 COG4191@1|root,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,47U6P@768503|Cytophagia 976|Bacteroidetes T SnoaL-like domain - - - - - - - - - - - - HATPase_c,HisKA,SnoaL_3 k59_246776_1 1461693.ATO10_14034 4.69e-82 265.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria 28211|Alphaproteobacteria P P-type ATPase' actP - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_301752_1 324602.Caur_1212 7.41e-23 100.0 COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi 200795|Chloroflexi P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_834864_2 236097.ADG881_1127 3.65e-09 61.2 COG0457@1|root,COG0457@2|Bacteria,1NB8N@1224|Proteobacteria,1SEZN@1236|Gammaproteobacteria,1XMRE@135619|Oceanospirillales 135619|Oceanospirillales S FOG TPR repeat - - - - - - - - - - - - TPR_11,TPR_6,TPR_8 k59_246787_1 1121335.Clst_1338 3.99e-96 292.0 COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,3WG9G@541000|Ruminococcaceae 186801|Clostridia E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35,4.2.1.85 ko:K01703,ko:K20452 ko00290,ko00660,ko00760,ko00966,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map00966,map01100,map01110,map01120,map01210,map01230 M00432,M00535 R03069,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00843,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS04465 Aconitase k59_873349_1 1121949.AQXT01000002_gene2716 1.75e-10 62.0 COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,2UFTM@28211|Alphaproteobacteria,43YAQ@69657|Hyphomonadaceae 28211|Alphaproteobacteria L Belongs to the UPF0102 family MA20_24645 - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_873349_2 1284708.HMPREF1634_00675 7.1e-31 115.0 COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,248HW@186801|Clostridia,3WCG4@538999|Clostridiales incertae sedis 186801|Clostridia D ATPases associated with a variety of cellular activities ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_1085318_2 1452718.JBOY01000105_gene428 7.62e-05 44.7 COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,1S2PS@1236|Gammaproteobacteria 1236|Gammaproteobacteria O methyltransferase activity - - 2.1.1.334 ko:K21310 ko00920,map00920 - R11546 RC02653 ko00000,ko00001,ko01000 - - - NnrU,PEMT k59_718827_1 266779.Meso_2118 1.84e-44 150.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,43J12@69277|Phyllobacteriaceae 28211|Alphaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_1245179_1 1321778.HMPREF1982_03735 1.36e-15 80.1 COG2199@1|root,COG2199@2|Bacteria,1UKQG@1239|Firmicutes,25G12@186801|Clostridia 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - GGDEF k59_559774_1 543913.D521_0651 2.49e-96 296.0 COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,2VJ21@28216|Betaproteobacteria,1KQI6@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria KT HD domain - - - - - - - - - - - - GAF,HD,HD_5 k59_1338401_1 1157708.KB907450_gene5728 0.000612 45.8 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2VHMV@28216|Betaproteobacteria,4AAI9@80864|Comamonadaceae 28216|Betaproteobacteria E peptidase dimerisation domain protein - - - ko:K13049 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1602877_1 1079460.ATTQ01000016_gene5398 9.67e-32 114.0 2C19F@1|root,32ZRH@2|Bacteria,1NJ8W@1224|Proteobacteria,2V4D2@28211|Alphaproteobacteria,4BFUV@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_189116_1 349163.Acry_0336 0.00037 43.5 COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,2TSH2@28211|Alphaproteobacteria,2JR2X@204441|Rhodospirillales 204441|Rhodospirillales C Prokaryotic cytochrome b561 - - - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Ni_hydr_CYTB k59_189116_2 443143.GM18_0459 1.53e-98 303.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2WJQS@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family hyaL - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_1665604_1 340.xcc-b100_1597 3.93e-53 183.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,1RN46@1236|Gammaproteobacteria,1X3IZ@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_928807_1 1123367.C666_16895 1.25e-91 290.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,2KVAJ@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_834899_1 189753.AXAS01000151_gene8503 7.45e-51 178.0 COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2TVFI@28211|Alphaproteobacteria,3JU9X@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L DNA invertase Pin - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom k59_1393784_1 1192034.CAP_2887 7.23e-27 107.0 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,42QT1@68525|delta/epsilon subdivisions,2WNK6@28221|Deltaproteobacteria,2YVMJ@29|Myxococcales 28221|Deltaproteobacteria H riboflavin synthase, alpha ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_301783_1 56780.SYN_00924 1.82e-63 211.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2WJ9G@28221|Deltaproteobacteria,2MQW7@213462|Syntrophobacterales 28221|Deltaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_353888_1 1049564.TevJSym_ap00680 2.2e-169 490.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1J4WR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_246813_1 67332.FM21_30200 3.41e-07 52.0 COG0512@1|root,COG0512@2|Bacteria,2GJUX@201174|Actinobacteria 201174|Actinobacteria EH Glutamine amidotransferase of anthranilate synthase trpG GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_246813_2 314285.KT71_02152 3.21e-53 178.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1J9I8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0421 Glycos_trans_3N,Glycos_transf_3 k59_1452364_1 1125863.JAFN01000001_gene78 8.54e-61 197.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,42MR6@68525|delta/epsilon subdivisions,2WITP@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TIGRFAM TRAP transporter solute receptor, TAXI family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_1512284_1 105559.Nwat_1420 7.85e-61 191.0 COG2193@1|root,COG2193@2|Bacteria,1RF3C@1224|Proteobacteria,1S72I@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Ferritin-like domain - - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_1029824_1 1278309.KB907105_gene1459 3.45e-27 112.0 COG0845@1|root,COG0845@2|Bacteria,1NKWA@1224|Proteobacteria,1RP0X@1236|Gammaproteobacteria,1XH6U@135619|Oceanospirillales 135619|Oceanospirillales M COG0845 Membrane-fusion protein - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_145986_1 1229909.NSED_07755 9.24e-15 69.3 COG1601@1|root,arCOG01640@2157|Archaea,41STZ@651137|Thaumarchaeota 651137|Thaumarchaeota J Translation initiation factor - - - ko:K03238 ko03013,map03013 - - - ko00000,ko00001,ko01009,ko03012 - - - eIF-5_eIF-2B k59_145986_2 1131266.ARWQ01000005_gene784 9.34e-33 116.0 COG2412@1|root,arCOG04051@2157|Archaea,41SS6@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF424) - - - ko:K09148 - - - - ko00000 - - - DUF424 k59_145986_3 1131266.ARWQ01000005_gene783 1.59e-05 44.3 COG0361@1|root,arCOG01179@2157|Archaea,41SRK@651137|Thaumarchaeota 651137|Thaumarchaeota J Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits - - - ko:K03236 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - eIF-1a k59_301817_1 622637.KE124774_gene620 1.06e-19 84.7 COG3832@1|root,COG3832@2|Bacteria,1RD9A@1224|Proteobacteria,2U76G@28211|Alphaproteobacteria,36Y4J@31993|Methylocystaceae 28211|Alphaproteobacteria S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 k59_301817_2 671143.DAMO_0122 5.01e-10 62.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity mxaE - - - - - - - - - - - Cytochrom_D1,Lactonase,NHL,PQQ_2 k59_768328_1 247634.GPB2148_1810 2.56e-80 248.0 COG1054@1|root,COG1054@2|Bacteria,1MUFV@1224|Proteobacteria,1RNNU@1236|Gammaproteobacteria,1J50A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0176 family yceA - - ko:K07146 - - - - ko00000 - - - Rhodanese,Rhodanese_C k59_928846_1 195253.Syn6312_3115 2.02e-77 243.0 COG0436@1|root,COG0436@2|Bacteria,1G0NC@1117|Cyanobacteria,1GYP3@1129|Synechococcus 1117|Cyanobacteria H Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate dapL - 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1544085_1 247633.GP2143_18226 9.55e-33 122.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,1J549@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - iSSON_1240.SSON_4131 Semialdhyde_dh,Semialdhyde_dhC k59_834959_1 1120953.AUBH01000010_gene78 2.83e-25 102.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,1RNXH@1236|Gammaproteobacteria,467YB@72275|Alteromonadaceae 1236|Gammaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_834959_2 330214.NIDE2069 2.74e-28 102.0 arCOG12353@1|root,33KP1@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_100527_1 492774.JQMB01000007_gene3886 1.57e-06 47.4 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2U9QB@28211|Alphaproteobacteria,4BEMP@82115|Rhizobiaceae 28211|Alphaproteobacteria O Belongs to the glutaredoxin family. Monothiol subfamily grlA - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin k59_100527_2 94624.Bpet1857 2e-13 68.6 COG2823@1|root,COG2823@2|Bacteria,1NIM8@1224|Proteobacteria,2WG5J@28216|Betaproteobacteria,3T7XW@506|Alcaligenaceae 28216|Betaproteobacteria S periplasmic or secreted lipoprotein - - - - - - - - - - - - BON k59_1665684_1 436308.Nmar_0037 1.78e-80 244.0 COG0602@1|root,arCOG02173@2157|Archaea,41SGM@651137|Thaumarchaeota 651137|Thaumarchaeota O Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_12,Radical_SAM k59_1665684_2 436308.Nmar_0036 5.8e-25 94.4 arCOG08815@1|root,arCOG08815@2157|Archaea,41T9N@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_873417_1 1123376.AUIU01000013_gene1907 2.91e-34 120.0 COG1324@1|root,COG1324@2|Bacteria,3J0UM@40117|Nitrospirae 40117|Nitrospirae P CutA1 divalent ion tolerance protein cutA - - ko:K03926 - - - - ko00000 - - - CutA1 k59_873417_2 289376.THEYE_A1195 2.89e-30 116.0 COG2309@1|root,COG2309@2|Bacteria 2|Bacteria E aminopeptidase activity - - - - - - - - - - - - Peptidase_M29 k59_1182244_2 1304275.C41B8_16379 1.45e-49 172.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - iJN746.PP_1032,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833 GATase,GMP_synt_C,NAD_synthase k59_1665699_1 436308.Nmar_1310 1.8e-89 267.0 COG0518@1|root,arCOG00090@2157|Archaea,41T3Z@651137|Thaumarchaeota 651137|Thaumarchaeota F glutamine amidotransferase - - - - - - - - - - - - GATase k59_1137414_2 105559.Nwat_2753 6.02e-16 80.9 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria,1WX4U@135613|Chromatiales 135613|Chromatiales T PFAM Metal-dependent phosphohydrolase, HD - - - - - - - - - - - - DUF3391,HD_5 k59_834996_1 1131814.JAFO01000001_gene3711 1.99e-09 65.5 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQX3@28211|Alphaproteobacteria,3F0K0@335928|Xanthobacteraceae 28211|Alphaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,Pkinase k59_301849_1 1439940.BAY1663_03356 5.7e-45 160.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria 1236|Gammaproteobacteria S associated with various cellular activities moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_718909_1 365044.Pnap_1254 9.28e-16 72.0 2DVDD@1|root,32UZ7@2|Bacteria,1NGRW@1224|Proteobacteria,2VY85@28216|Betaproteobacteria,4AEXN@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF2933) - - - - - - - - - - - - DUF2933 k59_718909_2 1235457.C404_26115 7.57e-70 215.0 COG2020@1|root,COG2020@2|Bacteria,1MUBZ@1224|Proteobacteria,2VJJ4@28216|Betaproteobacteria,1K3H0@119060|Burkholderiaceae 28216|Betaproteobacteria O Isoprenylcysteine carboxyl methyltransferase - - - - - - - - - - - - ICMT,PEMT k59_246874_2 1249627.D779_4060 7.85e-42 152.0 COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,1SX9U@1236|Gammaproteobacteria,1X0R6@135613|Chromatiales 135613|Chromatiales U Predicted Permease Membrane Region - - - - - - - - - - - - Asp-Al_Ex,TrkA_C k59_623745_2 401526.TcarDRAFT_1283 3.32e-123 386.0 COG1783@1|root,COG3780@1|root,COG5525@1|root,COG1783@2|Bacteria,COG3780@2|Bacteria,COG5525@2|Bacteria 2|Bacteria S Phage terminase large subunit (GpA) - - - ko:K06909 - - - - ko00000 - - - HTH_3,Terminase_6 k59_728835_1 997884.HMPREF1068_01946 2.44e-100 305.0 COG0513@1|root,COG0513@2|Bacteria,4NEVI@976|Bacteroidetes,2FM7Y@200643|Bacteroidia,4AKYN@815|Bacteroidaceae 976|Bacteroidetes JKL Belongs to the DEAD box helicase family rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_987415_1 1121440.AUMA01000010_gene326 5.56e-06 53.1 COG2890@1|root,COG2890@2|Bacteria,1QWA6@1224|Proteobacteria 1224|Proteobacteria J Methyltransferase domain - - 2.1.1.156 ko:K18896 ko00260,map00260 - R10060 RC00003,RC03038 ko00000,ko00001,ko01000 - - - Methyltransf_25 k59_569800_1 1229909.NSED_09505 3.35e-67 213.0 COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota 651137|Thaumarchaeota F Ribose-phosphate pyrophosphokinase - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran,Pribosyltran_N k59_883336_1 314285.KT71_10297 3.76e-72 220.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,1J972@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_313376_1 426117.M446_6918 2.32e-09 58.5 COG3378@1|root,COG5545@1|root,COG3378@2|Bacteria,COG5545@2|Bacteria,1QV7H@1224|Proteobacteria,2TUB1@28211|Alphaproteobacteria,1JXU5@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Phage plasmid primase P4 family - - - - - - - - - - - - PriCT_2 k59_313376_2 1280954.HPO_19237 4.41e-25 98.6 COG2963@1|root,COG2963@2|Bacteria,1NH66@1224|Proteobacteria,2UD9V@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Associated with IS66-like transposable element, conserved - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_623809_1 330214.NIDE1527 3.01e-17 82.0 COG3266@1|root,COG3266@2|Bacteria 2|Bacteria GM domain, Protein - - - ko:K18491 ko04550,map04550 - - - ko00000,ko00001,ko03000 - - - DUF4157 k59_1096863_1 335283.Neut_2463 1.1e-12 70.5 COG2010@1|root,COG2041@1|root,COG2010@2|Bacteria,COG2041@2|Bacteria,1N9MS@1224|Proteobacteria,2W0PY@28216|Betaproteobacteria,374QE@32003|Nitrosomonadales 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_1096863_2 1123033.ARNF01000051_gene1031 7.92e-10 59.3 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,3NKQ6@468|Moraxellaceae 1236|Gammaproteobacteria H GTP cyclohydrolase folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_201754_1 1070319.CAGGBEG34_200050 1.76e-41 147.0 COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,2VM5W@28216|Betaproteobacteria,1K4E6@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the carbamate kinase family arcC - 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase k59_201754_2 269799.Gmet_2785 9.59e-18 84.0 COG2403@1|root,COG2403@2|Bacteria,1MV4C@1224|Proteobacteria,42NE0@68525|delta/epsilon subdivisions,2WJ94@28221|Deltaproteobacteria,43TJC@69541|Desulfuromonadales 28221|Deltaproteobacteria S cyclic 2,3-diphosphoglycerate synthetase activity - - - - - - - - - - - - - k59_623822_1 518766.Rmar_1911 3.8e-38 142.0 COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1556236_4 1501230.ET33_16450 4.11e-24 114.0 COG2369@1|root,COG4383@1|root,COG2369@2|Bacteria,COG4383@2|Bacteria,1V0F9@1239|Firmicutes,4IRWE@91061|Bacilli 91061|Bacilli S Protein of unknown function (DUF935) - - - - - - - - - - - - DUF935 k59_1556236_5 1033737.CAEV01000076_gene518 1.1e-29 126.0 COG0507@1|root,COG0507@2|Bacteria,1TQWH@1239|Firmicutes,24A8I@186801|Clostridia,36H5N@31979|Clostridiaceae 186801|Clostridia L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - - k59_1096884_2 330214.NIDE2035 1.77e-18 84.7 COG1253@1|root,COG1253@2|Bacteria,3J0KN@40117|Nitrospirae 40117|Nitrospirae S Transporter associated domain - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_365082_1 1238182.C882_2847 1.34e-73 243.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria,2JQKB@204441|Rhodospirillales 204441|Rhodospirillales G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_201787_1 9606.ENSP00000455507 1.24e-08 63.2 KOG0032@1|root,KOG0613@1|root,KOG0032@2759|Eukaryota,KOG0613@2759|Eukaryota,38BY9@33154|Opisthokonta,3BDBV@33208|Metazoa,3CYKX@33213|Bilateria,483C0@7711|Chordata,4928T@7742|Vertebrata,3J24U@40674|Mammalia,35A5A@314146|Euarchontoglires,4M84D@9443|Primates,4MX5W@9604|Hominidae 33208|Metazoa TZ Protein kinase; unclassified specificity. OBSCN GO:0003674,GO:0003824,GO:0004672,GO:0005085,GO:0005088,GO:0005089,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005859,GO:0005863,GO:0005886,GO:0005911,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007010,GO:0007154,GO:0007165,GO:0007186,GO:0008092,GO:0008104,GO:0008150,GO:0008152,GO:0008307,GO:0009653,GO:0009966,GO:0009987,GO:0010646,GO:0010927,GO:0010941,GO:0010942,GO:0014704,GO:0015629,GO:0016020,GO:0016043,GO:0016301,GO:0016310,GO:0016459,GO:0016460,GO:0016604,GO:0016740,GO:0016772,GO:0016773,GO:0017016,GO:0017048,GO:0019538,GO:0019899,GO:0022607,GO:0023051,GO:0023052,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030054,GO:0030154,GO:0030239,GO:0030506,GO:0031032,GO:0031267,GO:0031430,GO:0031432,GO:0031672,GO:0031674,GO:0031974,GO:0031981,GO:0032502,GO:0032982,GO:0032989,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0036211,GO:0036309,GO:0036379,GO:0042383,GO:0042692,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043292,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044291,GO:0044421,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044449,GO:0044451,GO:0044464,GO:0045214,GO:0045296,GO:0046777,GO:0048468,GO:0048518,GO:0048522,GO:0048583,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050839,GO:0050896,GO:0051020,GO:0051056,GO:0051146,GO:0051179,GO:0051641,GO:0051716,GO:0055001,GO:0055002,GO:0061061,GO:0065007,GO:0065009,GO:0070013,GO:0070727,GO:0070925,GO:0071704,GO:0071840,GO:0071944,GO:0097435,GO:0098772,GO:0099080,GO:0099081,GO:0099512,GO:0140096,GO:1901564,GO:1902531 2.7.11.1 ko:K17531 - - - - ko00000,ko01000,ko01001,ko04131 - - - I-set,IQ,Ig_3,PH,Pkinase,RhoGEF,fn3,ig k59_201790_1 330214.NIDE3060 1.33e-101 299.0 COG2022@1|root,COG2022@2|Bacteria,3J0EI@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG k59_883367_1 1122603.ATVI01000006_gene33 2.53e-06 51.2 COG4968@1|root,COG4968@2|Bacteria 2|Bacteria NU Prokaryotic N-terminal methylation motif pilE2 - - ko:K02655 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - ComP_DUS,N_methyl k59_777955_1 330214.NIDE1649 2.92e-53 180.0 2AAUK@1|root,3107C@2|Bacteria,3J1E0@40117|Nitrospirae 40117|Nitrospirae S LPP20 lipoprotein - - - - - - - - - - - - LPP20 k59_623857_1 113395.AXAI01000001_gene2860 3.71e-29 112.0 COG2345@1|root,COG2345@2|Bacteria,1RIDX@1224|Proteobacteria,2U9M4@28211|Alphaproteobacteria,3JYN3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - - - - - - - - - - ATC_hydrolase k59_1039766_1 382245.ASA_1554 9e-52 174.0 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,1Y3ET@135624|Aeromonadales 135624|Aeromonadales M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_256849_1 1276756.AUEX01000035_gene2255 3.07e-29 111.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2VHY0@28216|Betaproteobacteria,4AA0X@80864|Comamonadaceae 28216|Betaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_256849_2 1340493.JNIF01000004_gene914 4.77e-23 98.6 COG1427@1|root,COG1427@2|Bacteria,3Y3PU@57723|Acidobacteria 57723|Acidobacteria S Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnA - 4.2.1.151 ko:K11782 ko00130,ko01110,map00130,map01110 - R10666 RC03232 ko00000,ko00001,ko01000 - - - VitK2_biosynth k59_623869_1 550540.Fbal_2343 8.01e-60 199.0 COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,1RP9G@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Flp pilus assembly protein ATPase CpaF tadA - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE k59_1350045_1 552811.Dehly_1596 1.81e-63 205.0 COG0031@1|root,COG0031@2|Bacteria,2G698@200795|Chloroflexi,34DQK@301297|Dehalococcoidia 2|Bacteria E PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit cysM GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.113,2.5.1.47 ko:K12339,ko:K21148 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04122,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map04122 M00021 R00897,R03132,R03601,R04859,R10610 RC00020,RC02814,RC02821,RC02876,RC03225 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1405395_1 794903.OPIT5_30655 2.92e-12 72.0 COG3547@1|root,COG3547@2|Bacteria,46WNP@74201|Verrucomicrobia 74201|Verrucomicrobia L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_987535_2 693977.Deipr_0963 2.79e-15 80.1 COG0438@1|root,COG0438@2|Bacteria,1WI3Z@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M PFAM Glycosyl transferase, group 1 - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_416765_1 330214.NIDE0418 1.24e-71 225.0 COG2255@1|root,COG2255@2|Bacteria,3J0AU@40117|Nitrospirae 40117|Nitrospirae L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_1193877_1 626887.J057_00160 2.57e-29 111.0 COG2010@1|root,COG2010@2|Bacteria,1RGXM@1224|Proteobacteria,1S976@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 k59_22929_1 749414.SBI_03857 3.55e-32 128.0 COG1397@1|root,COG1397@2|Bacteria,2GNSG@201174|Actinobacteria 201174|Actinobacteria O ADP-ribosylation crystallin J1 - - - - - - - - - - - - ADP_ribosyl_GH k59_1193905_1 297246.lpp1305 1.65e-85 267.0 COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,1RY9G@1236|Gammaproteobacteria,1JE37@118969|Legionellales 118969|Legionellales C Aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1611465_1 926569.ANT_04990 3.27e-16 74.3 COG1662@1|root,COG1662@2|Bacteria 2|Bacteria L PFAM IS1 transposase - - - ko:K07480 - - - - ko00000 - - - DDE_Tnp_IS1 k59_1611465_2 926569.ANT_30030 4.28e-42 141.0 COG3677@1|root,COG3677@2|Bacteria,2G9MB@200795|Chloroflexi 200795|Chloroflexi L Putative ATPase subunit of terminase (gpP-like) - - - - - - - - - - - - HTH_23 k59_416805_1 159087.Daro_0386 6.16e-25 107.0 COG3327@1|root,COG3327@2|Bacteria,1R4IF@1224|Proteobacteria,2VP5N@28216|Betaproteobacteria,2KVFG@206389|Rhodocyclales 206389|Rhodocyclales K PaaX family - - - ko:K02616 - - - - ko00000,ko03000 - - - PaaX,PaaX_C k59_987605_1 269799.Gmet_0002 2.13e-47 166.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,42NQW@68525|delta/epsilon subdivisions,2WJZM@28221|Deltaproteobacteria,43T1D@69541|Desulfuromonadales 28221|Deltaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_1350120_1 1085623.GNIT_2437 9e-21 97.8 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,465MZ@72275|Alteromonadaceae 1236|Gammaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_1405461_1 1555202.A0A097EYH4_9CAUD 1.99e-39 148.0 4QAKZ@10239|Viruses,4QPYH@28883|Caudovirales,4QIYN@10662|Myoviridae 10662|Myoviridae S exonuclease activity - - - - - - - - - - - - - k59_623977_1 309801.trd_A0506 1.13e-54 192.0 COG4867@1|root,COG4867@2|Bacteria,2G8A6@200795|Chloroflexi,27XPF@189775|Thermomicrobia 189775|Thermomicrobia S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_1193943_1 1237149.C900_01424 1.52e-26 107.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,47K8C@768503|Cytophagia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family bepE_4 - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1193943_2 1279009.ADICEAN_03272 1.21e-62 204.0 COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,47KNA@768503|Cytophagia 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_201943_1 1444711.CCJF01000005_gene376 9.77e-05 46.6 COG1028@1|root,COG1028@2|Bacteria,2JH2W@204428|Chlamydiae 204428|Chlamydiae IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_201943_2 292415.Tbd_0063 3.14e-15 73.6 2EH48@1|root,338P5@2|Bacteria,1NFS9@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_365199_1 1292020.H483_0100925 1.01e-23 102.0 COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria 201174|Actinobacteria EH Belongs to the TPP enzyme family ilvG GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv1820 TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1405487_1 247634.GPB2148_3327 1.02e-49 172.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,1RNCW@1236|Gammaproteobacteria,1J542@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S flavoproteins yhiN GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07007 - - - - ko00000 - - - HI0933_like k59_22945_1 1232410.KI421424_gene1839 1.78e-61 202.0 COG0477@1|root,COG2814@2|Bacteria,1QUY6@1224|Proteobacteria,43DH9@68525|delta/epsilon subdivisions,2X8P2@28221|Deltaproteobacteria 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1556430_1 644966.Tmar_0479 4.1e-102 315.0 COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,3WCXQ@538999|Clostridiales incertae sedis 186801|Clostridia IQ Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_365207_1 1120934.KB894403_gene291 5.98e-26 110.0 COG0028@1|root,COG0028@2|Bacteria,2GN3X@201174|Actinobacteria,4DXG7@85010|Pseudonocardiales 201174|Actinobacteria EH Belongs to the TPP enzyme family mdlC - 4.1.1.7 ko:K01576 ko00627,ko01120,map00627,map01120 - R01764,R02672 RC00595 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_987672_1 246200.SPO2715 2.36e-39 147.0 COG0845@1|root,COG2203@1|root,COG0845@2|Bacteria,COG2203@2|Bacteria,1N97Q@1224|Proteobacteria,2U22Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria M GAF domain protein - - - - - - - - - - - - Biotin_lipoyl_2,GAF,HlyD_3,HlyD_D23 k59_987672_2 1353537.TP2_00595 3.29e-12 66.2 COG1994@1|root,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,2U0H8@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Peptidase, M50 family - - - ko:K16922 - - - - ko00000,ko01002 - - - Biotin_lipoyl_2,PqqD k59_987692_1 330214.NIDE3561 1.56e-13 67.8 COG3748@1|root,COG3748@2|Bacteria,3J19B@40117|Nitrospirae 40117|Nitrospirae S Pfam:DUF989 - - - - - - - - - - - - Urate_ox_N k59_365228_2 1185652.USDA257_c25000 3.59e-16 82.8 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,2VF65@28211|Alphaproteobacteria,4BBA2@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase for insertion sequence element - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_883477_1 1005994.GTGU_02522 1.07e-10 61.6 COG2823@1|root,COG2823@2|Bacteria,1N0SU@1224|Proteobacteria,1S926@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Periplasmic or secreted lipoprotein osmY_1 - - ko:K04065 - - - - ko00000 - - - BON k59_624060_1 1121362.A605_04930 2.84e-16 78.2 COG0722@1|root,COG0722@2|Bacteria,2GMVF@201174|Actinobacteria,22KP3@1653|Corynebacteriaceae 201174|Actinobacteria E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) aroG - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_624060_2 243277.VC_A0527 2.65e-22 95.9 COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,1RPKP@1236|Gammaproteobacteria,1XSPY@135623|Vibrionales 135623|Vibrionales S GTPases (G3E family) - - - - - - - - - - - - cobW k59_416932_2 296591.Bpro_5331 1.95e-08 57.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2W02U@28216|Betaproteobacteria 28216|Betaproteobacteria M Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_1350210_1 1121422.AUMW01000034_gene2811 2.22e-42 150.0 COG1735@1|root,COG1735@2|Bacteria,1TS8I@1239|Firmicutes,249N0@186801|Clostridia,264S3@186807|Peptococcaceae 186801|Clostridia S metal-dependent hydrolase with the TIM-barrel fold - - - ko:K07048 - - - - ko00000 - - - PTE k59_365240_1 1289387.AUKW01000002_gene424 3.8e-50 176.0 COG0318@1|root,COG0318@2|Bacteria,2H21N@201174|Actinobacteria 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_256968_1 713586.KB900536_gene1527 1.97e-51 177.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Amino Acid - - - - - - - - - - - - AA_permease_2 k59_416961_2 395965.Msil_3335 2.12e-22 97.4 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TQSC@28211|Alphaproteobacteria,3NC2U@45404|Beijerinckiaceae 28211|Alphaproteobacteria L UvrD-like helicase C-terminal domain uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1194037_1 195250.CM001776_gene2578 1.42e-27 115.0 COG0028@1|root,COG0028@2|Bacteria 2|Bacteria EH Belongs to the TPP enzyme family oxc GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0008150,GO:0008152,GO:0008949,GO:0009056,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019752,GO:0019842,GO:0030554,GO:0030976,GO:0032553,GO:0032555,GO:0032559,GO:0033609,GO:0033611,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043531,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046872,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0071704,GO:0097159,GO:0097367,GO:0104004,GO:1901265,GO:1901363,GO:1901575,GO:1901681 4.1.1.8 ko:K01577 ko00630,ko01100,map00630,map01100 - R01908 RC00620 ko00000,ko00001,ko01000 - - iEcSMS35_1347.EcSMS35_2523,iNJ661.Rv0118c TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_778100_2 580332.Slit_2094 4.78e-47 160.0 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,2VIR4@28216|Betaproteobacteria,44VJE@713636|Nitrosomonadales 28216|Betaproteobacteria S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase opaA - 3.5.5.1 ko:K01501,ko:K11206 ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120 - R00540,R01887,R03093,R03542,R05591,R07855 RC00315,RC00325,RC00617,RC00959,RC02811 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_22979_1 1232683.ADIMK_0257 8.82e-13 70.5 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,465N7@72275|Alteromonadaceae 1236|Gammaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_22979_2 3750.XP_008371128.1 4.72e-23 99.0 COG1806@1|root,2QQ1R@2759|Eukaryota,37NRA@33090|Viridiplantae,3GFS0@35493|Streptophyta,4JDU0@91835|fabids 35493|Streptophyta S pyruvate, phosphate dikinase regulatory protein - GO:0003674,GO:0003824,GO:0004672,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.7.11.32,2.7.4.27 ko:K20115 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_729046_1 305900.GV64_22855 7.18e-05 50.4 COG0726@1|root,COG1361@1|root,COG2911@1|root,COG2931@1|root,COG3291@1|root,COG3533@1|root,COG4733@1|root,COG5434@1|root,COG0726@2|Bacteria,COG1361@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,COG3533@2|Bacteria,COG4733@2|Bacteria,COG5434@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1XRVR@135619|Oceanospirillales 135619|Oceanospirillales MQ Dystroglycan-type cadherin-like domains. - - - - - - - - - - - - - k59_202083_1 1211777.BN77_3957 7.4e-52 183.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc,TPR_16,TPR_19 k59_624140_1 1005048.CFU_1643 4.61e-50 167.0 COG0596@1|root,COG0596@2|Bacteria,1MWT6@1224|Proteobacteria,2VHJW@28216|Betaproteobacteria,475ZN@75682|Oxalobacteraceae 28216|Betaproteobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 k59_1556566_1 436308.Nmar_1479 2.53e-43 149.0 COG0214@1|root,arCOG04075@2157|Archaea,41SEJ@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the PdxS SNZ family - - 4.3.3.6 ko:K06215 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SOR_SNZ k59_1556566_2 1229909.NSED_08160 1.39e-45 152.0 arCOG08637@1|root,arCOG08637@2157|Archaea,41SV0@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_626620_1 1203554.HMPREF1476_02065 1.98e-06 47.8 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,2VSKZ@28216|Betaproteobacteria,4PR8G@995019|Sutterellaceae 28216|Betaproteobacteria G FKBP-type peptidyl-prolyl cis-trans isomerase fkpA - 5.2.1.8 ko:K03772,ko:K03773 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N k59_626622_1 1417296.U879_03690 2.76e-38 140.0 COG1145@1|root,COG1456@1|root,COG1145@2|Bacteria,COG1456@2|Bacteria,1R6BH@1224|Proteobacteria,2USUR@28211|Alphaproteobacteria 28211|Alphaproteobacteria C CO dehydrogenase/acetyl-CoA synthase delta subunit - - - - - - - - - - - - CdhD,Fer4 k59_1310265_1 1229909.NSED_03060 3.1e-33 123.0 COG0150@1|root,arCOG00639@2157|Archaea,41SEE@651137|Thaumarchaeota 651137|Thaumarchaeota F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1310265_2 1229909.NSED_03055 8.2e-58 190.0 COG0475@1|root,arCOG01953@2157|Archaea,41T00@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - - - - - - - - - - Na_H_Exchanger k59_892771_1 1123258.AQXZ01000013_gene1973 0.000115 45.1 COG0596@1|root,COG0596@2|Bacteria,2GKJB@201174|Actinobacteria,4G9TB@85025|Nocardiaceae 201174|Actinobacteria S Serine aminopeptidase, S33 dhmA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.8.1.5 ko:K01563 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1414802_1 59538.XP_005975251.1 1.36e-33 129.0 COG0056@1|root,KOG1353@2759|Eukaryota,38ERH@33154|Opisthokonta,3BCEE@33208|Metazoa,3CU79@33213|Bilateria,489CP@7711|Chordata,497ZQ@7742|Vertebrata,3J34Z@40674|Mammalia,4J1PP@91561|Cetartiodactyla 33208|Metazoa C ATP synthase, H transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle ATP5A1 - - ko:K02132 ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016 M00158 - - ko00000,ko00001,ko00002 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1414802_2 95619.PM1_0229070 1.55e-46 157.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953 OSCP k59_1414802_3 1485544.JQKP01000012_gene2166 5.14e-06 47.8 COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,2VRMS@28216|Betaproteobacteria,44VTQ@713636|Nitrosomonadales 28216|Betaproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_108612_1 710421.Mycch_1938 1e-56 184.0 COG0714@1|root,COG0714@2|Bacteria,2GWNF@201174|Actinobacteria,232BM@1762|Mycobacteriaceae 201174|Actinobacteria S CbbQ NirQ NorQ C-terminal - - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5,CbbQ_C k59_108612_2 525368.HMPREF0591_5061 1.57e-66 218.0 COG4548@1|root,COG4548@2|Bacteria,2GIYK@201174|Actinobacteria,234RV@1762|Mycobacteriaceae 201174|Actinobacteria P von willebrand factor type a - - - - - - - - - - - - VWA,VWA_2,VWA_CoxE k59_1153687_1 365528.KB891226_gene1284 3.45e-38 139.0 COG1028@1|root,COG1028@2|Bacteria,2I4ES@201174|Actinobacteria 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - GO:0003674,GO:0003824,GO:0004303,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006066,GO:0006629,GO:0007568,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0009719,GO:0009725,GO:0009987,GO:0010033,GO:0014070,GO:0016125,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0018812,GO:0030283,GO:0032502,GO:0033764,GO:0033993,GO:0042221,GO:0042493,GO:0042579,GO:0042802,GO:0042803,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044594,GO:0046983,GO:0048545,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071310,GO:0071407,GO:0071704,GO:1901360,GO:1901615,GO:1902652 - - - - - - - - - - adh_short k59_1153687_2 1150599.MPHLEI_23589 1.38e-48 159.0 COG1545@1|root,COG1545@2|Bacteria,2IFHZ@201174|Actinobacteria,238S7@1762|Mycobacteriaceae 201174|Actinobacteria S nucleic-acid-binding protein containing a Zn-ribbon - - - - - - - - - - - - DUF35_N,OB_aCoA_assoc k59_789149_1 1269813.ATUL01000004_gene2215 1.24e-18 83.6 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1WW4W@135613|Chromatiales 135613|Chromatiales L Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_789149_2 349124.Hhal_2084 2.13e-125 364.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1WW5R@135613|Chromatiales 135613|Chromatiales M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_1101688_1 436308.Nmar_0536 1.69e-22 91.7 COG1547@1|root,arCOG03705@2157|Archaea,41SQ0@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF309) - - - ko:K09763 - - - - ko00000 - - - DUF309 k59_789164_1 436308.Nmar_0714 2.25e-28 117.0 arCOG00373@1|root,arCOG00373@2157|Archaea,41ST8@651137|Thaumarchaeota 651137|Thaumarchaeota L ATPase involved in DNA repair - - - - - - - - - - - - - k59_1414831_1 1210884.HG799475_gene15269 3.39e-92 286.0 COG0033@1|root,COG0033@2|Bacteria,2IYG0@203682|Planctomycetes 203682|Planctomycetes G Phosphoglucomutase/phosphomannomutase, C-terminal domain - - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_57915_1 1123399.AQVE01000013_gene239 7.17e-60 202.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RR8J@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Extracellular solute-binding protein, family 5 ddpA GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - iB21_1397.B21_01457,iECBD_1354.ECBD_2152,iECB_1328.ECB_01445,iECD_1391.ECD_01445 SBP_bac_5 k59_2524_1 1397666.RS24_00789 6.19e-16 83.6 COG1216@1|root,COG1216@2|Bacteria,1N0WW@1224|Proteobacteria,2TXH9@28211|Alphaproteobacteria,4BSUV@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_2524_3 929712.KI912613_gene425 8.22e-09 57.8 COG2089@1|root,COG2089@2|Bacteria,2GJC9@201174|Actinobacteria 201174|Actinobacteria M synthase - - 2.5.1.56 ko:K01654 ko00520,ko01100,map00520,map01100 - R01804,R04435 RC00159 ko00000,ko00001,ko01000 - - - NeuB,SAF k59_789181_1 264732.Moth_2027 0.000293 50.1 COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,42G7V@68295|Thermoanaerobacterales 186801|Clostridia O PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin isp - 3.4.21.62 ko:K01342,ko:K13275 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Peptidase_S8 k59_996698_1 330214.NIDE3220 1.08e-67 213.0 COG2897@1|root,COG2897@2|Bacteria 2|Bacteria P thiosulfate sulfurtransferase activity rhdA - 2.8.1.1,2.8.1.11,2.8.1.2 ko:K01011,ko:K21028 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106,R07461 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_579189_1 1121940.AUDZ01000014_gene1258 3.58e-65 205.0 COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,1RPZ6@1236|Gammaproteobacteria,1XJ6Q@135619|Oceanospirillales 135619|Oceanospirillales D Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions slmA - - ko:K05501 - - - - ko00000,ko03000,ko03036 - - - TetR_N k59_1414855_2 3075.A0A087SQ16 3e-27 110.0 COG0414@1|root,KOG3042@2759|Eukaryota,37KSZ@33090|Viridiplantae,34JEA@3041|Chlorophyta 3041|Chlorophyta H Pantoate-beta-alanine ligase - - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_1049387_1 1353529.M899_3301 9.18e-11 67.4 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2MSR8@213481|Bdellovibrionales,2WJZF@28221|Deltaproteobacteria 213481|Bdellovibrionales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_422526_1 1123070.KB899263_gene1765 3.55e-87 274.0 COG3119@1|root,COG3119@2|Bacteria,46SHT@74201|Verrucomicrobia,2IUAW@203494|Verrucomicrobiae 74201|Verrucomicrobia P Sulfatase - - - - - - - - - - - - Sulfatase k59_213526_1 96561.Dole_2642 1.92e-11 61.6 COG0071@1|root,COG0071@2|Bacteria,1NA27@1224|Proteobacteria,42VE3@68525|delta/epsilon subdivisions,2WR9Q@28221|Deltaproteobacteria,2MKAV@213118|Desulfobacterales 28221|Deltaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_579191_1 994479.GL877879_gene5774 1.3e-17 85.5 COG0438@1|root,COG0438@2|Bacteria,2GNR8@201174|Actinobacteria,4EEII@85010|Pseudonocardiales 201174|Actinobacteria M Glycosyl transferase 4-like - - - ko:K19424 - - - - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_1362784_1 1088721.NSU_3538 3.53e-55 190.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSG6@28211|Alphaproteobacteria,2K2GG@204457|Sphingomonadales 204457|Sphingomonadales C FAD linked oxidases, C-terminal domain - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_474542_1 765914.ThisiDRAFT_1987 4.3e-06 52.0 COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,1T06C@1236|Gammaproteobacteria,1X2KY@135613|Chromatiales 135613|Chromatiales S PHB accumulation regulatory domain - - - - - - - - - - - - PHB_acc,PHB_acc_N k59_892820_1 44689.DDB0188248 1.61e-21 101.0 COG2937@1|root,COG3320@1|root,KOG1221@2759|Eukaryota,KOG3730@2759|Eukaryota,3XDXV@554915|Amoebozoa 554915|Amoebozoa I Catalyzes the reduction of fatty acyl-CoA to fatty alcohols - - 2.3.1.42 ko:K00649 ko00564,ko04146,map00564,map04146 - R01013 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Acyltransferase,NAD_binding_4,Sterile k59_2528_1 381666.H16_B2100 2.14e-24 106.0 COG0204@1|root,COG0236@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0236@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,1KG5N@119060|Burkholderiaceae 28216|Betaproteobacteria IQ amp-dependent synthetase and ligase - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,Acyltransferase,PP-binding k59_840438_1 767817.Desgi_4565 2.36e-61 202.0 COG0438@1|root,COG0438@2|Bacteria,1TPY6@1239|Firmicutes,24834@186801|Clostridia,261PX@186807|Peptococcaceae 186801|Clostridia M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_632604_1 1192124.LIG30_2971 2.06e-11 66.6 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,1K38N@119060|Burkholderiaceae 28216|Betaproteobacteria I Phospholipase D Transphosphatidylase - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_996723_1 1121033.AUCF01000010_gene4539 9.38e-20 87.4 COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,2U4JG@28211|Alphaproteobacteria,2JVHK@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source - - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,GATase_3 k59_996723_2 396588.Tgr7_2196 1.7e-47 164.0 COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,1RS7Z@1236|Gammaproteobacteria,1WX2A@135613|Chromatiales 135613|Chromatiales C PFAM Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_318427_1 420324.KI912061_gene6197 1.74e-97 315.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,1JR57@119045|Methylobacteriaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,Abhydrolase_1,Guanylate_cyc,TPR_4 k59_1571390_1 330214.NIDE1860 1.06e-05 55.1 COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae 2|Bacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - FGE-sulfatase k59_1153751_1 1336243.JAEA01000015_gene1199 4.48e-99 308.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,1JRYY@119045|Methylobacteriaceae 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily gsiA1 - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_370308_1 436308.Nmar_0648 8.85e-15 72.8 COG1899@1|root,arCOG04142@2157|Archaea,41SDB@651137|Thaumarchaeota 651137|Thaumarchaeota O Deoxyhypusine synthase - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS k59_370308_2 436308.Nmar_0649 9.05e-53 175.0 COG1260@1|root,arCOG04213@2157|Archaea,41SEZ@651137|Thaumarchaeota 651137|Thaumarchaeota I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth k59_318441_1 1229909.NSED_01945 2.64e-60 198.0 COG5253@1|root,arCOG04169@2157|Archaea,41S9X@651137|Thaumarchaeota 651137|Thaumarchaeota U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - Plug_translocon,SecY k59_318441_2 1229909.NSED_01950 3.46e-44 149.0 COG2019@1|root,arCOG01039@2157|Archaea,41SK7@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the archaeal adenylate kinase family adkA - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AAA_17 k59_1259381_2 265072.Mfla_0774 5.1e-05 47.4 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2VIV0@28216|Betaproteobacteria,2KM1M@206350|Nitrosomonadales 206350|Nitrosomonadales G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_1310340_1 272568.GDI3670 2.2e-43 164.0 COG0234@1|root,COG0234@2|Bacteria,1NJKP@1224|Proteobacteria,2UM25@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - - k59_109342_2 323261.Noc_0711 7.85e-57 181.0 COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,1S61I@1236|Gammaproteobacteria,1WYB4@135613|Chromatiales 135613|Chromatiales J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd - - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_423180_1 377629.TERTU_3172 7.18e-70 247.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,2PND5@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria NU Neisseria PilC beta-propeller domain pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_736533_1 543728.Vapar_2837 2.53e-09 63.2 COG4966@1|root,COG4966@2|Bacteria,1RC4Q@1224|Proteobacteria,2VS7N@28216|Betaproteobacteria,4ADXC@80864|Comamonadaceae 28216|Betaproteobacteria NU Type IV Pilus-assembly protein W pilW - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_475316_1 1249627.D779_1729 3.4e-96 284.0 COG4577@1|root,COG4577@2|Bacteria,1QG1Y@1224|Proteobacteria,1RXZV@1236|Gammaproteobacteria,1WWCC@135613|Chromatiales 135613|Chromatiales CQ BMC - - - - - - - - - - - - BMC k59_1311058_1 1538295.JY96_20905 6.39e-22 102.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2VJCZ@28216|Betaproteobacteria,1KJR8@119065|unclassified Burkholderiales 28216|Betaproteobacteria O peptidylprolyl isomerase ppiD - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_2746_1 391615.ABSJ01000038_gene406 2.47e-09 61.2 COG2433@1|root,COG2433@2|Bacteria,1N0ZS@1224|Proteobacteria,1SBFE@1236|Gammaproteobacteria,1J6Y2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Pfam Transposase IS66 - - - - - - - - - - - - - k59_2746_2 1298593.TOL_0206 2.53e-05 45.8 COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,1RPZ6@1236|Gammaproteobacteria,1XJ6Q@135619|Oceanospirillales 135619|Oceanospirillales D Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions slmA - - ko:K05501 - - - - ko00000,ko03000,ko03036 - - - TetR_N k59_893511_1 215803.DB30_4979 1.06e-51 179.0 COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,42NVI@68525|delta/epsilon subdivisions,2WJTD@28221|Deltaproteobacteria,2YTYS@29|Myxococcales 28221|Deltaproteobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1624589_2 1288826.MSNKSG1_09293 1.13e-30 121.0 COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,4647N@72275|Alteromonadaceae 1236|Gammaproteobacteria M N-acetylmuramoyl-L-alanine amidase amiC - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,LysM k59_475320_1 469383.Cwoe_5522 7.54e-15 74.3 COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,2IQ9F@201174|Actinobacteria,4CQW8@84995|Rubrobacteria 84995|Rubrobacteria H molybdopterin biosynthesis MoaE - - 2.8.1.12 ko:K03635,ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE,ThiS k59_475320_2 3067.XP_002955851.1 2.84e-10 63.2 COG0694@1|root,KOG2358@2759|Eukaryota,37TTM@33090|Viridiplantae,34I1X@3041|Chlorophyta 3041|Chlorophyta O NifU-like domain NifU - - - - - - - - - - - NifU k59_841107_1 330214.NIDE0568 3.46e-108 335.0 COG0178@1|root,COG0178@2|Bacteria,3J0C7@40117|Nitrospirae 40117|Nitrospirae L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_997484_1 1122604.JONR01000054_gene4083 2.44e-05 45.8 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1X34S@135614|Xanthomonadales 135614|Xanthomonadales G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_997484_2 243159.AFE_3250 4.92e-49 168.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria,2NC8E@225057|Acidithiobacillales 225057|Acidithiobacillales F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_633503_2 76114.c1A84 1.33e-25 102.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_685611_1 452662.SJA_C2-00350 7.67e-48 167.0 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2U4KB@28211|Alphaproteobacteria,2K1M8@204457|Sphingomonadales 204457|Sphingomonadales U Belongs to the GSP D family - - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - Secretin,T2SS-T3SS_pil_N k59_945157_1 373903.Hore_22850 4.25e-24 105.0 COG2244@1|root,COG2244@2|Bacteria,1VAKC@1239|Firmicutes,24PMX@186801|Clostridia 186801|Clostridia S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_C k59_790109_1 84531.JMTZ01000095_gene438 8.56e-104 336.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1X46E@135614|Xanthomonadales 135614|Xanthomonadales L Helicase lhr1 - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_1154485_1 765911.Thivi_2831 1.6e-22 99.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales 135613|Chromatiales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_1154485_2 768671.ThimaDRAFT_2579 4.98e-162 459.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,1WWUE@135613|Chromatiales 135613|Chromatiales J glycyl-tRNA synthetase alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_893534_1 530564.Psta_0960 3.42e-24 103.0 COG1389@1|root,COG1389@2|Bacteria,2J2A8@203682|Planctomycetes 203682|Planctomycetes L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6B - 5.99.1.3 ko:K03167 - - - - ko00000,ko01000,ko03032 - - - HATPase_c,Topo-VIb_trans k59_423207_1 1085623.GNIT_0517 1.62e-77 261.0 COG1352@1|root,COG2201@1|root,COG5001@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,465FS@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CBS,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_579925_1 1097668.BYI23_B012480 1.71e-11 71.2 COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VNBG@28216|Betaproteobacteria,1K297@119060|Burkholderiaceae 28216|Betaproteobacteria P Pfam Sulfatase betC - 3.1.6.6 ko:K01133 - - - - ko00000,ko01000 - - - Choline_sulf_C,DUF4976,Sulfatase k59_633524_1 768670.Calni_0521 1.56e-47 168.0 COG1055@1|root,COG1055@2|Bacteria 2|Bacteria P arsenite transmembrane transporter activity arsB - - - - - - - - - - - CitMHS k59_58881_1 46234.ANA_C10123 2.09e-59 203.0 COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria,1HJE5@1161|Nostocales 1117|Cyanobacteria E PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_531536_2 435908.IDSA_03310 4.13e-45 160.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,2QF5N@267893|Idiomarinaceae 1236|Gammaproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB GO:0000166,GO:0001716,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008734,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0015922,GO:0016491,GO:0016638,GO:0016641,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044318,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2574,iBWG_1329.BWG_2338,iECDH10B_1368.ECDH10B_2742,iECDH1ME8569_1439.ECDH1ME8569_2501,iETEC_1333.ETEC_2787,iEcDH1_1363.EcDH1_1094,iJO1366.b2574,iJR904.b2574,iLF82_1304.LF82_1433,iNRG857_1313.NRG857_12785,iY75_1357.Y75_RS13445,iYL1228.KPN_02899 FAD_binding_2,Succ_DH_flav_C k59_845185_3 521000.PROVRETT_05530 7.27e-15 70.5 COG3179@1|root,COG3179@2|Bacteria,1RE8K@1224|Proteobacteria,1S4U8@1236|Gammaproteobacteria,3Z9BP@586|Providencia 1236|Gammaproteobacteria S D-alanyl-D-alanine carboxypeptidase - - - - - - - - - - - - Peptidase_M15_4 k59_1521142_1 1313172.YM304_18730 8.4e-14 65.9 COG0228@1|root,COG0228@2|Bacteria,2IKU0@201174|Actinobacteria,4CNAD@84992|Acidimicrobiia 84992|Acidimicrobiia J Ribosomal protein S16 rpsP - - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_1521142_2 373903.Hore_07290 1.52e-24 104.0 COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,3WAIA@53433|Halanaerobiales 186801|Clostridia U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_638750_1 1100721.ALKO01000019_gene1395 1.87e-12 73.9 COG2863@1|root,COG2863@2|Bacteria,1MZU1@1224|Proteobacteria,2VU50@28216|Betaproteobacteria,4AAKY@80864|Comamonadaceae 28216|Betaproteobacteria C Cytochrome c class I cytC2 - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_1001207_1 159749.E7BWD2 1.43e-112 343.0 COG0086@1|root,2RUNJ@2759|Eukaryota,2XENN@2836|Bacillariophyta 2836|Bacillariophyta H DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates - GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0030880,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:1902494,GO:1990234 - - - - - - - - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3 k59_531537_1 1550073.JROH01000017_gene401 3.58e-110 331.0 COG1960@1|root,COG1960@2|Bacteria,1P8I7@1224|Proteobacteria,2U0AW@28211|Alphaproteobacteria,2K1N3@204457|Sphingomonadales 204457|Sphingomonadales C Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_949022_1 330214.NIDE2267 4.9e-45 161.0 COG2204@1|root,COG2204@2|Bacteria,3J0ZU@40117|Nitrospirae 40117|Nitrospirae T Bacterial regulatory protein, Fis family - - - ko:K07715 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_690275_1 697282.Mettu_4021 1.47e-107 317.0 COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,1RSAG@1236|Gammaproteobacteria,1XGED@135618|Methylococcales 135618|Methylococcales S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 k59_1054238_1 1304872.JAGC01000009_gene570 2.14e-39 144.0 COG1215@1|root,COG1215@2|Bacteria,1R988@1224|Proteobacteria,42QGX@68525|delta/epsilon subdivisions,2WJPU@28221|Deltaproteobacteria,2M8JN@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1367538_1 1279038.KB907338_gene1037 7.26e-64 216.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,2JPVD@204441|Rhodospirillales 204441|Rhodospirillales C Electron transfer flavoprotein-ubiquinone oxidoreductase - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_1001218_1 1151122.AQYD01000007_gene665 8.67e-13 75.5 COG2911@1|root,COG2931@1|root,COG3210@1|root,COG4070@1|root,COG4625@1|root,COG4932@1|root,COG5373@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4070@2|Bacteria,COG4625@2|Bacteria,COG4932@2|Bacteria,COG5373@2|Bacteria 2|Bacteria KLT membrane - - - ko:K02451,ko:K03832,ko:K13735,ko:K20276,ko:K21449 ko02024,ko05100,map02024,map05100 M00331 - - ko00000,ko00001,ko00002,ko02000,ko02044 1.B.40.2,2.C.1.1,9.B.42 - - PATR,T2SSB k59_1473537_1 1280001.BAOA01000207_gene2889 1.87e-55 179.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,1XU2T@135623|Vibrionales 135623|Vibrionales S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily yrdA - - - - - - - - - - - Hexapep k59_427322_1 1121413.JMKT01000015_gene245 3.97e-08 58.5 COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,42NZK@68525|delta/epsilon subdivisions,2WIY5@28221|Deltaproteobacteria,2MABK@213115|Desulfovibrionales 28221|Deltaproteobacteria NU Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_6,TPR_8,zinc_ribbon_4 k59_4479_2 329726.AM1_5107 3.75e-27 116.0 COG0515@1|root,COG0642@1|root,COG2202@1|root,COG2203@1|root,COG3437@1|root,COG3829@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,COG3829@2|Bacteria,COG3899@2|Bacteria 2|Bacteria T PFAM Protein kinase domain - - 1.8.1.9,2.7.13.3 ko:K00384,ko:K03407,ko:K11527 ko00450,ko02020,ko02030,map00450,map02020,map02030 M00506 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - AAA_16,GAF,GAF_2,GGDEF,HATPase_c,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Pkinase,Response_reg k59_1367547_1 1260251.SPISAL_07690 2.7e-59 201.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1WW2F@135613|Chromatiales 135613|Chromatiales P Chloride channel - - - - - - - - - - - - Voltage_CLC k59_638771_1 1380391.JIAS01000011_gene5426 1.57e-32 122.0 COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2TTX8@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG1960 Acyl-CoA dehydrogenases - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_638771_2 1122135.KB893134_gene3130 3.66e-36 134.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2TU8Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3,CTP_transf_3 k59_479825_1 398579.Spea_2648 3.92e-30 113.0 COG0810@1|root,COG0810@2|Bacteria,1R4VE@1224|Proteobacteria,1RQPV@1236|Gammaproteobacteria,2Q8TC@267890|Shewanellaceae 1236|Gammaproteobacteria U Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins tonB2 - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_1106575_1 436308.Nmar_0703 1.45e-97 292.0 COG0258@1|root,arCOG04050@2157|Archaea,41SBU@651137|Thaumarchaeota 651137|Thaumarchaeota L Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into fen - - ko:K04799 ko03030,ko03410,ko03450,map03030,map03410,map03450 - - - ko00000,ko00001,ko01000,ko03032,ko03400,ko04147 - - - XPG_I,XPG_N k59_1054254_2 522306.CAP2UW1_0635 1.83e-13 68.9 COG2165@1|root,COG2165@2|Bacteria,1REMT@1224|Proteobacteria,2VR8U@28216|Betaproteobacteria 28216|Betaproteobacteria NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl k59_1001235_2 472759.Nhal_3945 1.16e-29 108.0 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1WY0Q@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N k59_1473572_1 1244869.H261_09252 1.08e-12 68.9 COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,1MXK5@1224|Proteobacteria,2U13I@28211|Alphaproteobacteria,2JQVM@204441|Rhodospirillales 204441|Rhodospirillales S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - AMMECR1,Memo k59_64264_1 1303518.CCALI_00801 4.93e-84 258.0 COG0667@1|root,COG0667@2|Bacteria 2|Bacteria C Aldo Keto reductase - - 1.1.1.91 ko:K05882 - - - - ko00000,ko01000 - - - Aldo_ket_red k59_795666_1 435908.IDSA_02575 8.35e-82 249.0 COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,2QFM5@267893|Idiomarinaceae 1236|Gammaproteobacteria L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 k59_113199_2 342610.Patl_3299 3.46e-24 104.0 COG2271@1|root,COG2271@2|Bacteria,1MXUC@1224|Proteobacteria,1RRF8@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_1265560_1 98439.AJLL01000008_gene4021 1.32e-54 190.0 COG0154@1|root,COG0154@2|Bacteria,1G1MZ@1117|Cyanobacteria,1JJV1@1189|Stigonemataceae 1117|Cyanobacteria J Amidase nylA - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - iJN678.nylA Amidase k59_1213352_1 1122599.AUGR01000009_gene2383 1.09e-11 65.9 COG1132@1|root,COG1132@2|Bacteria,1N1Z8@1224|Proteobacteria,1RPVC@1236|Gammaproteobacteria,1XHHU@135619|Oceanospirillales 135619|Oceanospirillales V ABC transporter transmembrane region - - - ko:K06148 - - - - ko00000,ko02000 3.A.1 - - ABC_membrane,ABC_tran k59_1213352_2 1177928.TH2_12012 3.7e-42 147.0 COG0619@1|root,COG0619@2|Bacteria,1RJIT@1224|Proteobacteria,2U11T@28211|Alphaproteobacteria,2JSBQ@204441|Rhodospirillales 204441|Rhodospirillales P COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters - - - ko:K02008 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiQ k59_1473587_1 1237149.C900_03623 1.46e-65 209.0 COG0789@1|root,COG0789@2|Bacteria,4NERC@976|Bacteroidetes,47K07@768503|Cytophagia 976|Bacteroidetes K PFAM MerR family regulatory protein - - - ko:K22491 - - - - ko00000,ko03000 - - - B12-binding,B12-binding_2,MerR_1 k59_64274_1 1179773.BN6_76420 1.63e-05 52.0 COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria,4E023@85010|Pseudonocardiales 201174|Actinobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_950046_2 1123401.JHYQ01000004_gene2313 3.63e-22 91.3 COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,1S5XY@1236|Gammaproteobacteria,460VS@72273|Thiotrichales 72273|Thiotrichales S PFAM Uncharacterised protein family (UPF0093) - - - ko:K08973 - - - - ko00000 - - - UPF0093 k59_691295_2 1195246.AGRI_00940 8.06e-70 225.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,4653T@72275|Alteromonadaceae 1236|Gammaproteobacteria I Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed fadI GO:0003674,GO:0003824,GO:0003857,GO:0003988,GO:0004300,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033542,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - iECO103_1326.ECO103_2806,iEcHS_1320.EcHS_A2493 Thiolase_C,Thiolase_N k59_1521814_1 472759.Nhal_3102 7.26e-109 345.0 COG3280@1|root,COG3280@2|Bacteria,1QTVK@1224|Proteobacteria,1T1IP@1236|Gammaproteobacteria 1236|Gammaproteobacteria G synthase treY - 5.4.99.15 ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R09995 - ko00000,ko00001,ko00002,ko01000 - GH13 - Alpha-amylase k59_640097_1 2340.JV46_13040 7.76e-154 442.0 COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J85H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N,Transketolase_C k59_1107586_1 1282876.BAOK01000001_gene974 2.99e-70 221.0 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,2U3UR@28211|Alphaproteobacteria,4BR6M@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_1214317_1 1141136.K4F7H5_9CAUD 1.7e-45 168.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QHVQ@10662|Myoviridae 10662|Myoviridae S nucleotide binding - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016032,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019058,GO:0019079,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0039686,GO:0039693,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044403,GO:0044419,GO:0046483,GO:0051704,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_741484_1 864051.BurJ1DRAFT_3207 8.29e-16 77.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,2VQRJ@28216|Betaproteobacteria 28216|Betaproteobacteria M Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_428342_2 1238182.C882_4238 4.39e-48 159.0 COG1863@1|root,COG1863@2|Bacteria,1MZYJ@1224|Proteobacteria,2UBYN@28211|Alphaproteobacteria,2JTMZ@204441|Rhodospirillales 204441|Rhodospirillales P Na+/H+ ion antiporter subunit - - - ko:K05569 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MNHE k59_114209_2 1116472.MGMO_45c00400 7.27e-46 163.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1XE32@135618|Methylococcales 135618|Methylococcales K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_481136_1 177439.DP3020 1.61e-32 117.0 2DJ8V@1|root,3050U@2|Bacteria,1RE7U@1224|Proteobacteria 1224|Proteobacteria - - - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - - k59_481136_2 1218074.BAXZ01000006_gene1847 1.29e-23 92.8 COG3791@1|root,COG3791@2|Bacteria,1PSI4@1224|Proteobacteria,2WA8J@28216|Betaproteobacteria,1K9SV@119060|Burkholderiaceae 28216|Betaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_1576954_1 1131266.ARWQ01000006_gene254 1.16e-82 251.0 arCOG01781@1|root,arCOG01781@2157|Archaea,41T0U@651137|Thaumarchaeota 651137|Thaumarchaeota Q Protein of unknown function (DUF1698) - - - - - - - - - - - - Methyltransf_11 k59_797101_1 745310.G432_00080 1.05e-34 134.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2K0EB@204457|Sphingomonadales 204457|Sphingomonadales P P-type ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_797101_2 556268.OFAG_00774 8.92e-11 64.7 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEM@28216|Betaproteobacteria,478MR@75682|Oxalobacteraceae 28216|Betaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_1421265_1 1303518.CCALI_00706 3.96e-68 227.0 COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria 2|Bacteria H uroporphyrinogen-III synthase activity hemD GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,2.1.1.107,2.5.1.61,4.2.1.75,4.99.1.4 ko:K01719,ko:K01749,ko:K02302,ko:K02303,ko:K13542,ko:K13543 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084,R02864,R03165,R03194,R03947 RC00003,RC00871,RC01012,RC01034,RC01861,RC02317 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS15755,iJN678.hemD,iYO844.BSU15610 HEM4,TP_methylase k59_428354_1 1415780.JPOG01000001_gene1490 2.26e-92 278.0 COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,1RP7S@1236|Gammaproteobacteria,1X3G8@135614|Xanthomonadales 135614|Xanthomonadales S Acyltransferase VL23_19915 - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_428354_2 1046724.KB889862_gene1449 9.56e-25 101.0 COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,465QS@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the agmatine deiminase family aguA - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph k59_65558_1 160492.XF_1213 1.52e-44 160.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1X53V@135614|Xanthomonadales 135614|Xanthomonadales T gtp-binding protein typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_1368545_2 1232410.KI421416_gene2683 8.04e-60 205.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,42QJP@68525|delta/epsilon subdivisions,2WMET@28221|Deltaproteobacteria,43UGS@69541|Desulfuromonadales 28221|Deltaproteobacteria Q Multicopper oxidase ompC - 1.16.3.3 ko:K22350 - - - - ko00000,ko01000 - - - Cu-oxidase_2 k59_741505_1 1198232.CYCME_1006 9.57e-10 58.2 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,46080@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_741505_2 1379270.AUXF01000007_gene1042 5.18e-13 72.0 COG4257@1|root,COG4257@2|Bacteria,1ZUIM@142182|Gemmatimonadetes 142182|Gemmatimonadetes V antibiotic catabolic process - - - ko:K18235 - - - - ko00000,ko01000,ko01504 - - - - k59_428360_1 1469245.JFBG01000071_gene69 1.52e-96 292.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1WWGS@135613|Chromatiales 135613|Chromatiales E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide - - - - - - - - - - - - Cys_Met_Meta_PP k59_324507_1 867845.KI911784_gene674 1.2e-105 318.0 COG0498@1|root,COG0498@2|Bacteria,2G66Y@200795|Chloroflexi,375PP@32061|Chloroflexia 32061|Chloroflexia E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1159062_1 883.DvMF_2597 5.35e-45 157.0 COG0437@1|root,COG3064@1|root,COG0437@2|Bacteria,COG3064@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria,2M9HU@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein hmcB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Fer4_11,Fer4_4,Fer4_7 k59_1368553_1 1286106.MPL1_02218 7.03e-41 151.0 COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,1RSQ1@1236|Gammaproteobacteria,460MY@72273|Thiotrichales 72273|Thiotrichales S Zn-dependent protease - - - - - - - - - - - - Peptidase_M48 k59_950100_1 1229780.BN381_10319 4.25e-42 149.0 COG2050@1|root,COG2050@2|Bacteria,2I11Y@201174|Actinobacteria,3UXR4@52018|unclassified Actinobacteria (class) 201174|Actinobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_165085_1 765912.Thimo_1862 1.97e-82 251.0 COG1573@1|root,COG1573@2|Bacteria,1PIX8@1224|Proteobacteria,1S0RN@1236|Gammaproteobacteria,1X0GG@135613|Chromatiales 135613|Chromatiales L PFAM Uracil-DNA glycosylase superfamily - - - ko:K10800 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - - k59_114249_1 1386089.N865_08435 1.55e-37 136.0 COG2382@1|root,COG2382@2|Bacteria,2I844@201174|Actinobacteria,4FE3S@85021|Intrasporangiaceae 201174|Actinobacteria P Putative esterase - - - ko:K07214 - - - - ko00000 - - - DUF3327,Esterase k59_65589_1 502025.Hoch_2050 1.05e-83 263.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,42MA8@68525|delta/epsilon subdivisions,2WIXR@28221|Deltaproteobacteria,2YUA9@29|Myxococcales 28221|Deltaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_1630040_1 1229909.NSED_06850 3.19e-27 99.4 COG2888@1|root,arCOG01989@2157|Archaea,41T83@651137|Thaumarchaeota 651137|Thaumarchaeota J Zn-ribbon RNA-binding protein with a function in translation - - - ko:K07580 - - - - ko00000 - - - - k59_1630040_2 436308.Nmar_1220 1.37e-88 270.0 COG0644@1|root,arCOG00570@2157|Archaea,41SB5@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - - - - - - - - - - - k59_382636_3 1460634.JCM19037_1588 1.79e-23 94.7 COG0758@1|root,COG0758@2|Bacteria,1VNFT@1239|Firmicutes,4HZZP@91061|Bacilli 91061|Bacilli LU Protein of unknown function (DUF2493) - - - - - - - - - - - - DUF2493 k59_1373600_1 323261.Noc_1693 2.03e-154 456.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1WX4B@135613|Chromatiales 135613|Chromatiales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_1219572_1 1158292.JPOE01000005_gene68 8.57e-18 90.1 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,1KJ24@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Signal transducing histidine kinase, homodimeric domain pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_382647_1 1267533.KB906736_gene1246 7.51e-13 73.9 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia 204432|Acidobacteriia KLTU Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase k59_72283_1 580332.Slit_0044 3.99e-54 184.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,44VEF@713636|Nitrosomonadales 28216|Betaproteobacteria M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_1635806_1 1452718.JBOY01000008_gene3483 8.07e-15 73.9 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,1RNPM@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis yggS - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_1635806_2 1123256.KB907929_gene3351 1.49e-65 211.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1X3EY@135614|Xanthomonadales 135614|Xanthomonadales M Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - Peptidase_M23 k59_746596_1 533240.CRC_02945 2.27e-97 304.0 COG1166@1|root,COG1166@2|Bacteria,1G1C4@1117|Cyanobacteria,1HIE3@1161|Nostocales 1117|Cyanobacteria E Catalyzes the biosynthesis of agmatine from arginine speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_1428054_1 1121374.KB891590_gene1661 1.34e-11 70.1 COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,1RPGN@1236|Gammaproteobacteria 1236|Gammaproteobacteria MU outer membrane efflux protein - - - - - - - - - - - - OEP k59_1635809_1 391615.ABSJ01000052_gene1270 3.2e-41 155.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RNWM@1236|Gammaproteobacteria,1J4YY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_646964_1 269797.Mbar_A2962 2.19e-56 184.0 COG0778@1|root,arCOG00288@2157|Archaea,2XXW2@28890|Euryarchaeota,2N9TG@224756|Methanomicrobia 224756|Methanomicrobia C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_433539_2 706587.Desti_0365 1.45e-53 188.0 COG2114@1|root,COG2114@2|Bacteria 2|Bacteria T Pfam Adenylate and Guanylate cyclase catalytic domain cyaD - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - FHA,Fer2,GAF,GAF_2,Guanylate_cyc,Pkinase,Response_reg k59_433539_3 511.JT27_14430 3.11e-11 67.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,3T5YJ@506|Alcaligenaceae 28216|Betaproteobacteria T Hpt domain - - 2.7.13.3 ko:K07677 ko02020,ko02026,map02020,map02026 M00474 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,Response_reg k59_433539_4 743720.Psefu_3615 1.03e-25 101.0 COG1017@1|root,COG1017@2|Bacteria,1RI9P@1224|Proteobacteria,1S7H7@1236|Gammaproteobacteria 1236|Gammaproteobacteria C nitric oxide dioxygenase activity - - - - - - - - - - - - - k59_433539_5 1042209.HK44_006560 2.74e-85 289.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,1SE99@1236|Gammaproteobacteria 1236|Gammaproteobacteria T AAA ATPase domain - - - - - - - - - - - - AAA_16 k59_170214_2 1122147.AUEH01000047_gene2949 1.54e-16 76.6 COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,4HGXA@91061|Bacilli,3F65S@33958|Lactobacillaceae 91061|Bacilli K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_72301_1 1269813.ATUL01000001_gene1167 2.09e-71 223.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1WVVN@135613|Chromatiales 135613|Chromatiales EH TIGRFAM glutamine amidotransferase of anthranilate synthase - - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_277062_1 1449063.JMLS01000001_gene4067 1.29e-33 123.0 COG2370@1|root,COG2370@2|Bacteria,1V704@1239|Firmicutes,4HINW@91061|Bacilli,26TYW@186822|Paenibacillaceae 91061|Bacilli O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_1112759_1 1330700.JQNC01000003_gene911 2.9e-29 117.0 COG3258@1|root,COG3258@2|Bacteria,1WMNM@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_170220_1 1265310.CCBD010000024_gene1824 1.49e-97 301.0 COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria,232FY@1762|Mycobacteriaceae 201174|Actinobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1219600_1 404589.Anae109_3421 1.09e-93 279.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,42MFU@68525|delta/epsilon subdivisions,2WK74@28221|Deltaproteobacteria,2YUR2@29|Myxococcales 28221|Deltaproteobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_1219600_2 1242864.D187_003418 5.79e-17 79.3 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2WJ8Q@28221|Deltaproteobacteria,2YUHC@29|Myxococcales 28221|Deltaproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_488182_2 1250006.JHZZ01000001_gene1461 2.18e-46 158.0 COG0568@1|root,COG0568@2|Bacteria,4NEBF@976|Bacteroidetes,1HWSN@117743|Flavobacteriia,3VVHZ@52959|Polaribacter 976|Bacteroidetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_851402_1 1201290.M902_3203 2.14e-25 110.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,42MN4@68525|delta/epsilon subdivisions,2WJJ5@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_1113655_1 637389.Acaty_c0611 1.31e-174 528.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,2NCSH@225057|Acidithiobacillales 225057|Acidithiobacillales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_648122_1 1122135.KB893134_gene3645 2.25e-39 140.0 COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2TSUU@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.79,1.1.1.81 ko:K12972 ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120 - R00465,R01388,R01392,R02527 RC00031,RC00042,RC00670 ko00000,ko00001,ko01000 - - - 2-Hacid_dh_C k59_648122_2 318586.Pden_4942 4.18e-11 63.2 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2U30X@28211|Alphaproteobacteria,2PYG1@265|Paracoccus 28211|Alphaproteobacteria EH Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_590917_2 1469245.JFBG01000014_gene2026 6.48e-44 149.0 2C1YH@1|root,32R9E@2|Bacteria,1RF0Z@1224|Proteobacteria 1224|Proteobacteria S Tripartite tricarboxylate transporter TctB family - - - - - - - - - - - - TctB k59_956179_1 641526.ADIWIN_2729 1.25e-21 91.7 COG2524@1|root,COG2524@2|Bacteria,4PKJK@976|Bacteroidetes,1I18Z@117743|Flavobacteriia 976|Bacteroidetes K CBS domain - - - - - - - - - - - - CBS k59_121674_1 330214.NIDE4308 8.16e-12 62.8 COG0824@1|root,COG0824@2|Bacteria,3J1EV@40117|Nitrospirae 40117|Nitrospirae S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT k59_434643_1 335283.Neut_1507 7.74e-87 277.0 COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,2VPI8@28216|Betaproteobacteria,372CD@32003|Nitrosomonadales 28216|Betaproteobacteria I PFAM Prenyltransferase squalene oxidase shc - 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 - R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 - - - SQHop_cyclase_C,SQHop_cyclase_N k59_648143_1 1077974.GOEFS_050_00750 5.3e-12 70.9 COG0183@1|root,COG0183@2|Bacteria,2I3PP@201174|Actinobacteria,4GH79@85026|Gordoniaceae 201174|Actinobacteria I Acetyl-CoA acetyltransferase - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - - k59_330585_1 570952.ATVH01000014_gene2306 8.25e-136 390.0 COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07497 - - - - ko00000 - - - HTH_28,HTH_32,rve,rve_3 k59_1429202_1 502025.Hoch_5038 9.43e-40 151.0 COG0265@1|root,COG0823@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,42Z17@68525|delta/epsilon subdivisions,2WURE@28221|Deltaproteobacteria,2YUPJ@29|Myxococcales 28221|Deltaproteobacteria O Peptidase family M28 - - - - - - - - - - - - PA,PD40,PDZ_2,Peptidase_M28 k59_538488_1 861299.J421_3453 4.68e-47 169.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1ZSPW@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT Sigma factor PP2C-like phosphatases - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - SpoIIE k59_805201_1 1144275.COCOR_06731 2.11e-51 179.0 COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 k59_1429209_1 472759.Nhal_0669 2.24e-56 187.0 COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,1RPU2@1236|Gammaproteobacteria,1WWU8@135613|Chromatiales 135613|Chromatiales S SpoVR family - - - ko:K06415 - - - - ko00000 - - - SpoVR k59_805205_1 1347086.CCBA010000046_gene2463 0.000176 48.5 COG0668@1|root,COG0668@2|Bacteria,1TQXJ@1239|Firmicutes,4HCK2@91061|Bacilli,1ZF3F@1386|Bacillus 91061|Bacilli M Conserved TM helix ygxB - - - - - - - - - - - TM_helix k59_1113692_1 272123.Anacy_4479 2.39e-75 240.0 COG0577@1|root,COG0577@2|Bacteria,1G20M@1117|Cyanobacteria,1HKH0@1161|Nostocales 1117|Cyanobacteria V TIGRFAM DevC protein devC - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_7632_1 446462.Amir_1569 1.91e-16 83.2 COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4DXFX@85010|Pseudonocardiales 201174|Actinobacteria I acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_7632_2 391735.Veis_1133 1.35e-47 164.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VP70@28216|Betaproteobacteria 28216|Betaproteobacteria C acyl-CoA dehydrogenase - - 1.3.8.3,1.3.8.7 ko:K00249,ko:K07545 ko00071,ko00280,ko00410,ko00623,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01220,ko03320,map00071,map00280,map00410,map00623,map00640,map01100,map01110,map01120,map01130,map01200,map01212,map01220,map03320 M00013,M00036,M00087,M00418 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R05584 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246,RC02037 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_538504_1 448385.sce0051 4.95e-31 123.0 COG0517@1|root,COG0517@2|Bacteria,1QZT1@1224|Proteobacteria,43CN4@68525|delta/epsilon subdivisions,2X7VC@28221|Deltaproteobacteria,2Z3IG@29|Myxococcales 28221|Deltaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_1061743_1 1082933.MEA186_02207 3.96e-50 176.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TSIY@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1636969_1 370438.PTH_2517 9.73e-84 257.0 COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,260YV@186807|Peptococcaceae 186801|Clostridia C PFAM isocitrate isopropylmalate dehydrogenase icd - 1.1.1.41,1.1.1.83,1.1.1.93,4.1.1.73 ko:K00030,ko:K07246 ko00020,ko00630,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00650,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00215,R00709,R01751,R02545,R06180 RC00084,RC00105,RC00114,RC00594 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_1525946_1 768671.ThimaDRAFT_3829 5.14e-46 162.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1WXET@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_8,RnfC_N,SLBB k59_1525946_2 1283300.ATXB01000001_gene1162 4.16e-10 59.3 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1XE3B@135618|Methylococcales 135618|Methylococcales C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_171100_1 1141136.K4F657_9CAUD 1.02e-59 201.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae 10662|Myoviridae S Type III restriction enzyme, res subunit - - - - - - - - - - - - - k59_1275037_1 1265502.KB905938_gene2475 1.45e-64 211.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2VJ84@28216|Betaproteobacteria,4AACJ@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_1482953_1 1121090.KB894687_gene749 2.72e-26 105.0 COG2057@1|root,COG2057@2|Bacteria,1V0R2@1239|Firmicutes 1239|Firmicutes I PFAM Coenzyme A transferase gctB - 2.8.3.12 ko:K01040 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_1636970_1 1229909.NSED_06010 1.24e-25 102.0 arCOG08737@1|root,arCOG08737@2157|Archaea,41T1W@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1636970_2 436308.Nmar_1021 0.000217 45.1 arCOG08738@1|root,arCOG08738@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - SHOCT k59_648189_1 269799.Gmet_1913 7.5e-78 249.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,42MG0@68525|delta/epsilon subdivisions,2WJE1@28221|Deltaproteobacteria,43TYY@69541|Desulfuromonadales 28221|Deltaproteobacteria J PFAM tRNA synthetase, class II (G, H, P and S) hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_648189_2 795359.TOPB45_0801 7.79e-32 118.0 COG2062@1|root,COG2062@2|Bacteria 2|Bacteria T phosphohistidine phosphatase, SixA sixA - 3.6.1.55 ko:K03574,ko:K08296 - - - - ko00000,ko01000,ko03400 - - - His_Phos_1 k59_1482960_1 1041146.ATZB01000008_gene2192 5.6e-100 310.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_852379_1 1267535.KB906767_gene4368 3.96e-19 85.5 COG0399@1|root,COG0399@2|Bacteria,3Y2QT@57723|Acidobacteria 57723|Acidobacteria E DegT/DnrJ/EryC1/StrS aminotransferase family - - 2.6.1.102 ko:K13010 ko00520,map00520 - R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k59_852379_2 706587.Desti_5071 4.97e-21 95.5 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42S05@68525|delta/epsilon subdivisions,2WQP8@28221|Deltaproteobacteria,2MS6K@213462|Syntrophobacterales 28221|Deltaproteobacteria M PFAM Bacterial sugar transferase - - - - - - - - - - - - Bac_transf,CoA_binding_3 k59_278145_1 298655.KI912266_gene4041 1.96e-48 166.0 COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria 201174|Actinobacteria S Pfam Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1583207_1 1122194.AUHU01000011_gene1653 3.28e-21 94.4 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,465B4@72275|Alteromonadaceae 1236|Gammaproteobacteria U General secretion pathway protein F gspF - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_1583207_2 247634.GPB2148_2790 1.57e-15 77.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1J57U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU secretory pathway xpsE GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_805241_1 1126627.BAWE01000005_gene5307 8.78e-140 406.0 COG0687@1|root,COG0687@2|Bacteria,1MW93@1224|Proteobacteria,2TRJQ@28211|Alphaproteobacteria,3JWBS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Bacterial extracellular solute-binding protein MA20_32195 - - ko:K02055 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - SBP_bac_8,TAT_signal k59_1429245_1 765911.Thivi_1311 2.95e-06 47.8 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1WVXY@135613|Chromatiales 135613|Chromatiales J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_1429245_2 1286106.MPL1_10262 4.67e-26 109.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,4603W@72273|Thiotrichales 72273|Thiotrichales M PFAM Transglycosylase SLT domain - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_1164043_1 396588.Tgr7_2193 8.82e-138 409.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1WWDT@135613|Chromatiales 135613|Chromatiales C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Fer4_7,Fer4_9,Pyr_redox_2 k59_1636980_2 754477.Q7C_2470 1.44e-57 188.0 COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,1RNJE@1236|Gammaproteobacteria,45ZYN@72273|Thiotrichales 72273|Thiotrichales E phosphoserine phosphatase - - 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - HAD,Hydrolase k59_1525962_1 237368.SCABRO_00438 9.55e-22 97.8 COG4191@1|root,COG4191@2|Bacteria,2J1UB@203682|Planctomycetes 203682|Planctomycetes T Histidine kinase - - - - - - - - - - - - - k59_648212_1 875328.JDM601_2174 3.08e-105 312.0 COG1024@1|root,COG1024@2|Bacteria,2H2U8@201174|Actinobacteria,23AUU@1762|Mycobacteriaceae 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17,4.2.1.18 ko:K01692,ko:K13766 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00036,M00087 R02085,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115,RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1061774_1 1123499.KB908034_gene320 5.17e-06 50.8 COG4255@1|root,COG4255@2|Bacteria,1RJS3@1224|Proteobacteria,2VTT7@28216|Betaproteobacteria,2KR2U@206351|Neisseriales 206351|Neisseriales S Protein conserved in bacteria - - - - - - - - - - - - - k59_1061774_2 83406.HDN1F_22480 2.4e-95 298.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1J5AY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG0608 Single-stranded DNA-specific exonuclease recJ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_598025_1 1282361.ABAC402_09530 1.03e-07 58.5 COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria,2U29F@28211|Alphaproteobacteria,2KFNA@204458|Caulobacterales 204458|Caulobacterales S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_1284680_1 1121121.KB894297_gene4109 6.48e-07 50.4 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HAZP@91061|Bacilli,26QJW@186822|Paenibacillaceae 91061|Bacilli V ABC transporter, ATP-binding protein - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1284680_2 315456.RF_0428 1e-45 157.0 COG3173@1|root,COG3173@2|Bacteria,1R5XN@1224|Proteobacteria,2U3K7@28211|Alphaproteobacteria,47FBB@766|Rickettsiales 766|Rickettsiales S Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_1645470_1 101510.RHA1_ro03858 5.62e-40 149.0 COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria,4G5QD@85025|Nocardiaceae 201174|Actinobacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_337502_1 412965.COSY_0601 1.26e-14 79.3 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1J4CJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O peptidyl-prolyl isomerase ppiD GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0061077,GO:0071575,GO:0071944,GO:0098552 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_657640_1 290397.Adeh_2220 6.58e-80 248.0 COG0258@1|root,COG0258@2|Bacteria,1QV40@1224|Proteobacteria,43BZM@68525|delta/epsilon subdivisions,2X7AE@28221|Deltaproteobacteria,2YUE3@29|Myxococcales 28221|Deltaproteobacteria L Helix-hairpin-helix class 2 (Pol1 family) motifs - - - - - - - - - - - - 5_3_exonuc,5_3_exonuc_N k59_657640_2 247633.GP2143_01965 2.78e-13 69.7 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria 1236|Gammaproteobacteria E alanine symporter - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_11369_1 1469245.JFBG01000007_gene703 1.95e-137 400.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1WWJA@135613|Chromatiales 135613|Chromatiales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_658849_1 1121004.ATVC01000032_gene2209 3.59e-10 61.6 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,2KPG8@206351|Neisseriales 206351|Neisseriales C Psort location Cytoplasmic, score sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_658849_2 551789.ATVJ01000001_gene988 1.71e-11 67.8 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria,43WUZ@69657|Hyphomonadaceae 28211|Alphaproteobacteria C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1326461_2 500640.CIT292_07830 1.97e-19 90.1 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,1RMYF@1236|Gammaproteobacteria,3WWQH@544|Citrobacter 1236|Gammaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_1069606_1 443144.GM21_3999 9.45e-59 203.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,43TW3@69541|Desulfuromonadales 28221|Deltaproteobacteria C NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein nuoL-1 - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_286144_1 1123242.JH636435_gene2087 2.82e-54 194.0 COG0515@1|root,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes 203682|Planctomycetes T Serine threonine protein kinase - - - - - - - - - - - - Pkinase k59_1646663_1 1121939.L861_04065 6.33e-13 72.8 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1XH2Z@135619|Oceanospirillales 135619|Oceanospirillales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_1016725_1 316067.Geob_3114 3.94e-28 117.0 COG2159@1|root,COG2159@2|Bacteria,1PZGJ@1224|Proteobacteria,42YDG@68525|delta/epsilon subdivisions,2WTX4@28221|Deltaproteobacteria,43T1W@69541|Desulfuromonadales 28221|Deltaproteobacteria S Amidohydrolase - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_1069616_1 589865.DaAHT2_0484 1.29e-62 205.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42N7X@68525|delta/epsilon subdivisions,2WMM9@28221|Deltaproteobacteria,2MMU3@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_963963_2 1469245.JFBG01000013_gene1922 2.77e-47 154.0 COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,1S5ZA@1236|Gammaproteobacteria,1WYFA@135613|Chromatiales 135613|Chromatiales P part of a sulfur-relay system - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_84115_1 1223523.H340_17442 2.96e-47 166.0 COG0409@1|root,COG0409@2|Bacteria,2GMHA@201174|Actinobacteria 201174|Actinobacteria O hydrogenase expression formation protein HypD hypD - - ko:K04654 - - - - ko00000 - - - HypD k59_84115_2 290397.Adeh_0473 6.07e-22 94.4 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,42M3M@68525|delta/epsilon subdivisions,2WJ8B@28221|Deltaproteobacteria,2YTZM@29|Myxococcales 28221|Deltaproteobacteria O hydrogenase expression formation protein HypE hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_546114_1 268746.Q58M37_BPPRM 1.81e-42 145.0 4QD3S@10239|Viruses,4QS0E@28883|Caudovirales,4QK4Z@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_546114_2 268747.Q58LL7_BPPRS 1.75e-06 55.8 4QCZH@10239|Viruses,4QXH3@35237|dsDNA viruses no RNA stage,4QPND@28883|Caudovirales,4QI11@10662|Myoviridae 10662|Myoviridae S Bacteriophage T4 gp9/10-like protein - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098025 - - - - - - - - - - - k59_1285952_1 1249627.D779_3613 2.96e-112 334.0 COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,1RRMX@1236|Gammaproteobacteria,1WXC1@135613|Chromatiales 135613|Chromatiales G RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site cbbL - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N k59_1326498_1 69279.BG36_09625 2.32e-33 129.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,43P3V@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_1439732_1 1121920.AUAU01000016_gene1295 3.43e-83 263.0 COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria 57723|Acidobacteria T Response regulator receiver - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1439733_1 436308.Nmar_0096 2.19e-106 324.0 COG0443@1|root,arCOG03060@2157|Archaea,41SCM@651137|Thaumarchaeota 651137|Thaumarchaeota O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1170105_1 1166948.JPZL01000001_gene2442 1.92e-92 281.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XICI@135619|Oceanospirillales 135619|Oceanospirillales O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04691,ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_1591357_1 1121405.dsmv_1458 2.83e-121 362.0 COG4799@1|root,COG4799@2|Bacteria,1Q9BU@1224|Proteobacteria,42P34@68525|delta/epsilon subdivisions,2WK9S@28221|Deltaproteobacteria,2MI0B@213118|Desulfobacterales 28221|Deltaproteobacteria I Carboxyl transferase domain gcdA - 4.1.1.70 ko:K01615 ko00362,ko00650,ko01120,map00362,map00650,map01120 - R03028 RC00832 ko00000,ko00001,ko01000,ko02000 3.B.1.1.3 - - Carboxyl_trans k59_84137_1 635013.TherJR_2518 9.96e-118 353.0 COG0263@1|root,COG0263@2|Bacteria,1TPG6@1239|Firmicutes,2486P@186801|Clostridia,260P5@186807|Peptococcaceae 186801|Clostridia E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_84137_2 634956.Geoth_1085 3.54e-13 75.1 COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,4HAUV@91061|Bacilli,1WED9@129337|Geobacillus 91061|Bacilli S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_286194_1 1232437.KL662020_gene692 2.16e-97 305.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42NDG@68525|delta/epsilon subdivisions,2WKYU@28221|Deltaproteobacteria,2MISU@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_233117_2 443143.GM18_3605 3.63e-09 60.5 COG2199@1|root,COG3706@2|Bacteria 2|Bacteria T GGDEF domain cheY - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheX,HATPase_c,HisKA,Response_reg k59_177124_1 1126627.BAWE01000005_gene5306 1.18e-89 272.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,3JR68@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P TOBE domain MA20_32190 - 3.6.3.31 ko:K02052,ko:K11072 ko02010,ko02024,map02010,map02024 M00193,M00299 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11,3.A.1.11.1 - - ABC_tran,TOBE_2 k59_705330_1 477641.MODMU_4082 5.92e-40 134.0 2EE1U@1|root,337WK@2|Bacteria 2|Bacteria S Protein of unknown function (DUF3303) - - - - - - - - - - - - DUF3303 k59_1016768_1 1528106.JRJE01000031_gene3544 1.56e-89 279.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,2JQE2@204441|Rhodospirillales 204441|Rhodospirillales Q COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - - - - - - - - - - DctM k59_84153_1 351348.Maqu_1481 1.58e-21 97.8 COG3380@1|root,COG3380@2|Bacteria,1R5C0@1224|Proteobacteria,1S3X1@1236|Gammaproteobacteria,46BAC@72275|Alteromonadaceae 1236|Gammaproteobacteria S NAD FAD-dependent oxidoreductase - - - ko:K06955 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 k59_1170116_1 864702.OsccyDRAFT_3884 1.02e-54 186.0 COG0598@1|root,COG0598@2|Bacteria,1G1AG@1117|Cyanobacteria,1H99G@1150|Oscillatoriales 1117|Cyanobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_1591379_1 1279017.AQYJ01000028_gene2137 4.37e-55 193.0 COG0308@1|root,COG0308@2|Bacteria,1PJTM@1224|Proteobacteria,1SYS3@1236|Gammaproteobacteria,4672R@72275|Alteromonadaceae 1236|Gammaproteobacteria E Peptidase family M1 domain - - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - ERAP1_C,Peptidase_M1 k59_755527_1 756272.Plabr_0942 1.71e-42 159.0 COG0841@1|root,COG0841@2|Bacteria,2IY0K@203682|Planctomycetes 203682|Planctomycetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_131268_1 2903.EOD26371 1.06e-12 68.2 2EJSG@1|root,2SPVR@2759|Eukaryota 2759|Eukaryota - - - - - - - - - - - - - - - k59_84159_2 97138.C820_02415 1.04e-25 106.0 COG1208@1|root,COG1208@2|Bacteria 2|Bacteria JM COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon - - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_1121615_1 1249627.D779_0807 2.19e-27 103.0 COG0432@1|root,COG0432@2|Bacteria,1RIKJ@1224|Proteobacteria,1S8QM@1236|Gammaproteobacteria,1WYII@135613|Chromatiales 135613|Chromatiales S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_912983_1 159450.NH14_22640 6.44e-32 123.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria,1K1I1@119060|Burkholderiaceae 28216|Betaproteobacteria M PFAM VacJ family lipoprotein vacJ - - ko:K04754 - - - - ko00000 - - - MlaA k59_815992_1 876044.IMCC3088_219 2.64e-13 76.6 COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,1RV34@1236|Gammaproteobacteria,1J897@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_3 k59_964021_1 203122.Sde_0806 1.8e-80 257.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,4646Q@72275|Alteromonadaceae 1236|Gammaproteobacteria F COG0138 AICAR transformylase IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) purH GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - iEcHS_1320.EcHS_A4240,iPC815.YPO3728 AICARFT_IMPCHas,MGS k59_392011_2 469383.Cwoe_3930 1.58e-32 123.0 COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria,4CQAE@84995|Rubrobacteria 84995|Rubrobacteria IQ Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short_C2 k59_444012_1 641524.ADICYQ_5435 1.13e-11 67.8 COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,47KC3@768503|Cytophagia 976|Bacteroidetes Q PFAM D-aminoacylase, C-terminal region - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 k59_1646765_1 1348657.M622_04425 2.84e-23 99.8 COG0778@1|root,COG0778@2|Bacteria 2|Bacteria C coenzyme F420-1:gamma-L-glutamate ligase activity - - - - - - - - - - - - Nitroreductase k59_1439807_1 998674.ATTE01000001_gene2520 3.42e-34 125.0 COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,4602B@72273|Thiotrichales 72273|Thiotrichales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrD - 1.6.5.8 ko:K00349 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_1439807_2 631362.Thi970DRAFT_02715 9.61e-16 75.5 COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,1RR85@1236|Gammaproteobacteria,1X0NY@135613|Chromatiales 135613|Chromatiales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrC - - - - - - - - - - - FMN_bind k59_1121639_1 1506583.JQJY01000004_gene3054 1.15e-09 57.4 COG3832@1|root,COG3832@2|Bacteria,4NFVK@976|Bacteroidetes,1I2NR@117743|Flavobacteriia,2NVJM@237|Flavobacterium 976|Bacteroidetes S Activator of Hsp90 ATPase - - - - - - - - - - - - AHSA1 k59_1121639_2 114615.BRADO4030 1.6e-29 113.0 COG2175@1|root,COG2175@2|Bacteria,1P6UZ@1224|Proteobacteria,2TTJB@28211|Alphaproteobacteria,3JVNR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_658993_1 338969.Rfer_0831 4.31e-41 155.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2VJ54@28216|Betaproteobacteria,4ACBR@80864|Comamonadaceae 28216|Betaproteobacteria O AAA domain - - - - - - - - - - - - AAA_32,Lon_C k59_1531981_1 70448.A0A090N3Z3 4.85e-25 104.0 COG0626@1|root,KOG0053@2759|Eukaryota,37K09@33090|Viridiplantae,34GXJ@3041|Chlorophyta 3041|Chlorophyta E Cys/Met metabolism PLP-dependent enzyme CGS1 - 2.5.1.48 ko:K01739 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00420,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_1531981_2 1206741.BAFX01000075_gene3948 3.42e-24 103.0 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4FVUB@85025|Nocardiaceae 201174|Actinobacteria J Belongs to the amidase family - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_913015_1 1454004.AW11_00730 4.08e-131 387.0 COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,2WF2J@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_32,Mu-transpos_C,rve k59_286250_2 1454004.AW11_03199 5.75e-15 71.2 COG5156@1|root,COG5156@2|Bacteria,1N53Q@1224|Proteobacteria,2W66Z@28216|Betaproteobacteria 28216|Betaproteobacteria DO anaphase-promoting complex-dependent catabolic process - - - - - - - - - - - - - k59_444026_1 1336803.PHEL49_2372 3.83e-10 61.6 COG0596@1|root,COG0596@2|Bacteria,4PMBK@976|Bacteroidetes,1IJQW@117743|Flavobacteriia,3VVN2@52959|Polaribacter 976|Bacteroidetes S Ndr family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4,Abhydrolase_6 k59_444026_2 190650.CC_0285 1.82e-34 130.0 COG3920@1|root,COG3920@2|Bacteria,1MXIC@1224|Proteobacteria,2U1HI@28211|Alphaproteobacteria,2KI12@204458|Caulobacterales 204458|Caulobacterales T Histidine kinase - - - - - - - - - - - - HATPase_c_2,HisKA_2,PAS_9 k59_1170146_1 1232437.KL661966_gene3144 4.38e-43 147.0 2C477@1|root,32RDF@2|Bacteria,1RKW1@1224|Proteobacteria,42SWN@68525|delta/epsilon subdivisions,2WP88@28221|Deltaproteobacteria,2MNB4@213118|Desulfobacterales 28221|Deltaproteobacteria S DGC domain - - - - - - - - - - - - DGC k59_392035_1 1410619.SRDD_27860 4.96e-18 82.4 COG2067@1|root,COG2067@2|Bacteria,1RF1Y@1224|Proteobacteria,1T0CE@1236|Gammaproteobacteria 1236|Gammaproteobacteria I long-chain fatty acid transport protein - - - - - - - - - - - - - k59_500168_1 857087.Metme_4192 3.16e-91 270.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,1S21E@1236|Gammaproteobacteria,1XEKU@135618|Methylococcales 135618|Methylococcales H May be involved in the biosynthesis of molybdopterin moaB - 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_1439839_1 986075.CathTA2_3067 6.76e-19 86.3 COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,4HAH3@91061|Bacilli 91061|Bacilli E Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - iSB619.SA_RS12695 Aminotran_1_2 k59_1439839_2 1365176.N186_09690 2.88e-37 140.0 COG1028@1|root,arCOG01259@2157|Archaea,2XQK3@28889|Crenarchaeota 28889|Crenarchaeota I KR domain - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_95090_1 1121921.KB898706_gene2360 2.93e-05 45.1 2DQKY@1|root,337IG@2|Bacteria,1NCYH@1224|Proteobacteria,1SCMR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124 k59_95090_2 566466.NOR53_3044 3.46e-37 134.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1SM2C@1236|Gammaproteobacteria,1J8UW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - - - - - - - - - - - DAP_epimerase k59_827668_1 506534.Rhein_0377 1.01e-33 130.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1RYRB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B k59_1080064_1 1236541.BALL01000035_gene3616 2.02e-16 80.5 COG2268@1|root,COG2268@2|Bacteria,1P50K@1224|Proteobacteria,1RRHJ@1236|Gammaproteobacteria,2Q8JJ@267890|Shewanellaceae 1236|Gammaproteobacteria S PFAM band 7 protein yqiK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K07192 ko04910,map04910 - - - ko00000,ko00001,ko03036,ko04131,ko04147 - - - Band_7,Flot k59_713698_1 1232410.KI421412_gene412 3.43e-54 182.0 COG0755@1|root,COG0755@2|Bacteria,1RCCI@1224|Proteobacteria,42PVM@68525|delta/epsilon subdivisions,2WJ7I@28221|Deltaproteobacteria,43SCE@69541|Desulfuromonadales 28221|Deltaproteobacteria O Cytochrome C assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_511726_1 1265313.HRUBRA_00804 2.12e-65 202.0 COG0288@1|root,COG0288@2|Bacteria,1R3SC@1224|Proteobacteria,1SNG7@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_670519_1 870187.Thini_3341 3.61e-281 785.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,4604K@72273|Thiotrichales 72273|Thiotrichales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_923539_1 1279015.KB908461_gene1813 3.38e-52 174.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1Y42E@135624|Aeromonadales 135624|Aeromonadales M Arabinose 5-phosphate isomerase - - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_923539_2 1165096.ARWF01000001_gene1408 4.54e-34 123.0 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,2VRQX@28216|Betaproteobacteria,2KMW1@206350|Nitrosomonadales 206350|Nitrosomonadales S TIGRFAM 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family - - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 k59_606526_1 444860.E3SJ18_9CAUD 4.91e-28 111.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae 10662|Myoviridae S Type III restriction enzyme, res subunit - - - - - - - - - - - - - k59_606526_2 444860.E3SJ19_9CAUD 7.94e-59 185.0 4QBZY@10239|Viruses,4QW0D@35237|dsDNA viruses no RNA stage,4QQYZ@28883|Caudovirales,4QI5Q@10662|Myoviridae 10662|Myoviridae S Pfam:Sm_like - - - - - - - - - - - - - k59_554563_1 1254432.SCE1572_46645 9.28e-11 67.8 COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,42MS6@68525|delta/epsilon subdivisions,2WIYE@28221|Deltaproteobacteria,2YUMA@29|Myxococcales 28221|Deltaproteobacteria M Glycosyl transferase family 21 - - - - - - - - - - - - Glyco_tranf_2_3 k59_399513_1 298655.KI912266_gene4194 1.89e-42 149.0 COG2124@1|root,COG2124@2|Bacteria,2GJ3T@201174|Actinobacteria 201174|Actinobacteria Q cytochrome P450 - - - - - - - - - - - - p450 k59_399513_2 1205680.CAKO01000002_gene2546 2.71e-30 119.0 COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2TRXY@28211|Alphaproteobacteria 28211|Alphaproteobacteria P PFAM amidohydrolase MA20_19310 - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_923542_1 1121939.L861_22555 8.77e-21 96.3 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RR0R@1236|Gammaproteobacteria,1XN85@135619|Oceanospirillales 135619|Oceanospirillales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,Peptidase_M41 k59_1132139_1 1121403.AUCV01000022_gene3511 2.25e-61 200.0 COG1817@1|root,COG1817@2|Bacteria,1NE3M@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF354) - - - ko:K09726 - - - - ko00000 - - - DUF354 k59_670548_1 1254432.SCE1572_03080 2.09e-93 303.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2YUJI@29|Myxococcales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1297527_1 1122180.Lokhon_00115 7.12e-36 133.0 COG0463@1|root,COG0463@2|Bacteria,1QU5I@1224|Proteobacteria,2TW0F@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Glycosyltransferases involved in cell wall biogenesis - - - ko:K16556 - - - - ko00000,ko01000,ko01003 - GT2 - Glyco_tranf_2_3,Glycos_transf_2 k59_763289_1 1229909.NSED_08225 5.96e-07 50.1 arCOG08038@1|root,arCOG08733@1|root,arCOG08038@2157|Archaea,arCOG08733@2157|Archaea 2157|Archaea S protein secretion by the type IV secretion system - - - - - - - - - - - - - k59_348616_1 227377.CBU_0297 1.14e-47 159.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1JDC6@118969|Legionellales 118969|Legionellales L Endonuclease/Exonuclease/phosphatase family exoA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_348616_2 1453501.JELR01000002_gene980 6.15e-07 51.2 2DP15@1|root,3303T@2|Bacteria,1N7NN@1224|Proteobacteria,1S90P@1236|Gammaproteobacteria,468AH@72275|Alteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4426) PP5099 - - - - - - - - - - - DUF4426 k59_1658450_1 1123399.AQVE01000035_gene3176 5.94e-56 188.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S dicluster domain dsrK - - - - - - - - - - - CCG,Fer4_17,Fer4_8 k59_1658450_2 2340.JV46_15440 5.05e-28 112.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster dsrL - - - - - - - - - - - Fer4,Fer4_20,Fer4_7,Fer4_9,NADH_4Fe-4S,Pyr_redox_2 k59_972269_2 1095743.HMPREF1054_0350 4.49e-14 69.7 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,1S9NV@1236|Gammaproteobacteria,1Y8V4@135625|Pasteurellales 135625|Pasteurellales U Preprotein translocase subunit YajC yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_972269_3 1396418.BATQ01000001_gene1250 1.31e-15 76.6 COG0343@1|root,COG0343@2|Bacteria,46TZR@74201|Verrucomicrobia,2ITG4@203494|Verrucomicrobiae 203494|Verrucomicrobiae J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_454471_1 502025.Hoch_3063 2.4e-43 163.0 COG1404@1|root,COG1404@2|Bacteria,1PDEH@1224|Proteobacteria,4308G@68525|delta/epsilon subdivisions,2WVF7@28221|Deltaproteobacteria,2YYHW@29|Myxococcales 28221|Deltaproteobacteria O GON domain - - - - - - - - - - - - GON k59_1505192_1 765912.Thimo_1853 8.42e-15 74.3 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RXZ5@1236|Gammaproteobacteria,1WXP8@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator, LysR - - - - - - - - - - - - HTH_1,LysR_substrate k59_1505192_2 1255043.TVNIR_1245 6.05e-59 192.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,1RVJU@1236|Gammaproteobacteria,1WXJS@135613|Chromatiales 135613|Chromatiales I Poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009058,GO:0016234,GO:0042618,GO:0042619,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0070088,GO:0071704,GO:1901440,GO:1901441,GO:1901576 - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1024700_1 1210884.HG799464_gene10820 4.97e-54 184.0 COG1233@1|root,COG1233@2|Bacteria,2IYPF@203682|Planctomycetes 203682|Planctomycetes Q COG1233 Phytoene dehydrogenase and related - - - - - - - - - - - - Amino_oxidase k59_1448170_1 243090.RB11945 2.54e-61 209.0 COG1012@1|root,COG1012@2|Bacteria,2IZ2G@203682|Planctomycetes 203682|Planctomycetes C Aldehyde dehydrogenase family - - 1.2.1.3,1.2.99.10 ko:K00128,ko:K22445 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_923577_2 1121033.AUCF01000003_gene3110 6.19e-11 67.4 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,2JPCA@204441|Rhodospirillales 204441|Rhodospirillales E NAD-specific glutamate dehydrogenase gdhA - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_141377_1 880072.Desac_0419 1.72e-229 657.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MQZP@213462|Syntrophobacterales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-2 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1505206_2 479432.Sros_8039 1.4e-89 270.0 COG4122@1|root,COG4122@2|Bacteria,2GP7A@201174|Actinobacteria,4EIZN@85012|Streptosporangiales 201174|Actinobacteria S O-methyltransferase - - 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_3 k59_1334159_1 1380391.JIAS01000017_gene697 2.04e-112 358.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2U0IT@28211|Alphaproteobacteria,2JQVP@204441|Rhodospirillales 204441|Rhodospirillales V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_1177946_1 279714.FuraDRAFT_1443 8.58e-28 103.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2VRQ3@28216|Betaproteobacteria,2KR3Y@206351|Neisseriales 206351|Neisseriales J endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_1177946_2 396595.TK90_2001 4.41e-14 73.6 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_923592_1 1182553.XP_007749116.1 0.000111 43.9 COG0179@1|root,KOG1535@2759|Eukaryota,39B2A@33154|Opisthokonta,3NWDW@4751|Fungi,3QM1A@4890|Ascomycota,20CMF@147545|Eurotiomycetes 4751|Fungi Q Fumarylacetoacetate (FAA) hydrolase family - - - - - - - - - - - - FAA_hydrolase k59_454485_1 1335757.SPICUR_01930 7.08e-56 188.0 COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,1RZ65@1236|Gammaproteobacteria,1WWIJ@135613|Chromatiales 135613|Chromatiales S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 k59_348660_1 998674.ATTE01000001_gene2055 7.47e-77 253.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,4609P@72273|Thiotrichales 72273|Thiotrichales J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_670623_1 1150621.SMUL_1305 1.15e-10 59.3 COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,42TGG@68525|delta/epsilon subdivisions,2YPWP@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Probably plays a role in a hydrogenase nickel cofactor insertion step hypA - - ko:K04651 - - - - ko00000,ko03110 - - - HypA k59_670623_2 1120951.AUBG01000009_gene2861 8.7e-27 108.0 COG1024@1|root,COG1024@2|Bacteria,4NHRF@976|Bacteroidetes,1HXUI@117743|Flavobacteriia 976|Bacteroidetes I Belongs to the enoyl-CoA hydratase isomerase family - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_348677_1 330214.NIDE1291 1.86e-82 265.0 COG0210@1|root,COG0210@2|Bacteria,3J0VX@40117|Nitrospirae 40117|Nitrospirae L UvrD-like helicase C-terminal domain - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1334180_1 1249627.D779_0094 1.17e-33 131.0 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,1WW6H@135613|Chromatiales 135613|Chromatiales F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1389608_1 1120956.JHZK01000032_gene109 6.94e-51 183.0 COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,2TRSY@28211|Alphaproteobacteria,1JPUN@119043|Rhodobiaceae 28211|Alphaproteobacteria V ABC transporter transmembrane region - - - ko:K02021 - - - - ko00000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran,cNMP_binding k59_511849_1 323261.Noc_0992 3.3e-53 184.0 COG0412@1|root,COG0412@2|Bacteria,1QW3K@1224|Proteobacteria,1S38F@1236|Gammaproteobacteria,1X0ND@135613|Chromatiales 135613|Chromatiales Q Alpha/beta hydrolase family - - - - - - - - - - - - - k59_1448209_1 1265505.ATUG01000001_gene3881 1.2e-43 162.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales 28221|Deltaproteobacteria M TIGRFAM penicillin-binding protein, 1A family mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_241710_1 338969.Rfer_1708 3.6e-05 47.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,4A9QR@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_241710_2 314278.NB231_13886 2.38e-09 57.8 COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,1S0KH@1236|Gammaproteobacteria,1WX4D@135613|Chromatiales 135613|Chromatiales O PFAM protein-L-isoaspartate(D-aspartate) O-methyltransferase - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_554647_1 1380370.JIBA01000012_gene3893 1.1e-09 66.2 COG0477@1|root,COG0477@2|Bacteria,2GITS@201174|Actinobacteria,4FIM0@85021|Intrasporangiaceae 201174|Actinobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_555866_1 485915.Dret_1780 1.64e-35 126.0 COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,42RQI@68525|delta/epsilon subdivisions,2WNEC@28221|Deltaproteobacteria,2MBFG@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM Protein-tyrosine phosphatase, low molecular weight arsC - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_973557_2 869662.M4PMR1_9CAUD 1.07e-17 75.9 4QHHP@10239|Viruses,4QWAC@35237|dsDNA viruses no RNA stage,4QS3Z@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_16613_1 713586.KB900536_gene512 1.6e-35 130.0 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,1S66F@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Aspartyl protease - - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_764524_1 351348.Maqu_1161 1.25e-65 209.0 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria,4649H@72275|Alteromonadaceae 1236|Gammaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_764524_2 637905.SVI_2797 3.26e-101 303.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,2QAZI@267890|Shewanellaceae 1236|Gammaproteobacteria J Belongs to the pseudouridine synthase RsuA family rluB GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_764524_3 1249627.D779_2229 4.23e-17 78.2 COG2231@1|root,COG2231@2|Bacteria,1RDJ8@1224|Proteobacteria,1RUHP@1236|Gammaproteobacteria,1WXXG@135613|Chromatiales 135613|Chromatiales L PFAM HhH-GPD - - - ko:K07457 - - - - ko00000 - - - HhH-GPD k59_1335200_1 1521187.JPIM01000048_gene77 5.32e-41 148.0 COG3677@1|root,COG3677@2|Bacteria,2G6SJ@200795|Chloroflexi,3772U@32061|Chloroflexia 32061|Chloroflexia L PFAM Transposase IS66 family - - - - - - - - - - - - - k59_555881_2 908612.HMPREF9720_1632 1.91e-13 69.3 COG0792@1|root,COG0792@2|Bacteria,4NS7E@976|Bacteroidetes,2FSN9@200643|Bacteroidia,22UMY@171550|Rikenellaceae 976|Bacteroidetes L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_555881_3 338969.Rfer_3751 1.96e-10 60.5 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2VJQQ@28216|Betaproteobacteria,4ACYP@80864|Comamonadaceae 28216|Betaproteobacteria F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates mtnP - 2.4.2.28 ko:K00772,ko:K03815 ko00230,ko00270,ko01100,ko01110,map00230,map00270,map01100,map01110 M00034 R01402,R02297 RC00063,RC00122,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_973566_1 638303.Thal_1471 6.8e-90 277.0 COG1260@1|root,COG1260@2|Bacteria,2G3U0@200783|Aquificae 200783|Aquificae I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth k59_1025925_1 1193181.BN10_1380007 7.04e-137 402.0 COG0076@1|root,COG0076@2|Bacteria,2GKIH@201174|Actinobacteria,4FEQX@85021|Intrasporangiaceae 201174|Actinobacteria E decarboxylase - - 4.1.1.11,4.1.1.25,4.1.2.27 ko:K01634,ko:K18933 ko00350,ko00410,ko00600,ko00680,ko00770,ko01100,ko01110,ko04071,map00350,map00410,map00600,map00680,map00770,map01100,map01110,map04071 M00100 R00489,R00736,R02464,R06516 RC00264,RC00299,RC00721,RC01266 ko00000,ko00001,ko00002,ko01000 - - - Pyridoxal_deC k59_1506964_1 1167006.UWK_02124 4.95e-11 65.1 COG2825@1|root,COG2825@2|Bacteria,1MZVJ@1224|Proteobacteria,42VH3@68525|delta/epsilon subdivisions,2WP6K@28221|Deltaproteobacteria,2MK60@213118|Desulfobacterales 28221|Deltaproteobacteria M PFAM Outer membrane - - - ko:K06142 - - - - ko00000 - - - OmpH k59_513553_1 1173027.Mic7113_1642 1.88e-26 105.0 COG0226@1|root,COG0226@2|Bacteria,1G0JS@1117|Cyanobacteria,1H9HY@1150|Oscillatoriales 1117|Cyanobacteria P Phosphate ABC transporter substrate-binding protein - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_772524_1 404589.Anae109_3834 6.46e-64 211.0 COG1055@1|root,COG1055@2|Bacteria,1MXKG@1224|Proteobacteria,42PAX@68525|delta/epsilon subdivisions,2WKEP@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Putative citrate transport - - - - - - - - - - - - CitMHS_2 k59_1186375_1 491915.Aflv_2726 5.3e-89 273.0 COG1494@1|root,COG1494@2|Bacteria,1TP0D@1239|Firmicutes,4H9MV@91061|Bacilli,21V1Z@150247|Anoxybacillus 91061|Bacilli G Bacterial fructose-1,6-bisphosphatase, glpX-encoded glpX GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11 ko:K02446 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 - - - FBPase_glpX k59_1342643_1 1379270.AUXF01000004_gene3177 8.59e-29 110.0 COG1127@1|root,COG1127@2|Bacteria,1ZT5N@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_1342643_2 379066.GAU_3856 1.35e-16 80.5 COG1463@1|root,COG1463@2|Bacteria,1ZUJC@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_1398111_1 420324.KI911948_gene9127 5.98e-80 254.0 COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,2TSJR@28211|Alphaproteobacteria,1JT4U@119045|Methylobacteriaceae 28211|Alphaproteobacteria E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N k59_980087_1 765420.OSCT_0041 2.79e-60 198.0 COG1131@1|root,COG1131@2|Bacteria,2G7U7@200795|Chloroflexi,37725@32061|Chloroflexia 32061|Chloroflexia V PFAM ABC transporter related - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_306597_1 935839.JAGJ01000013_gene2855 2.42e-81 257.0 COG4222@1|root,COG4222@2|Bacteria,2GJN8@201174|Actinobacteria,4F3JV@85017|Promicromonosporaceae 201174|Actinobacteria S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_1456724_1 2340.JV46_25110 6.22e-63 198.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,1RN1J@1236|Gammaproteobacteria,1J6BT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k59_772568_1 1266914.ATUK01000012_gene212 9.73e-214 600.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria,1WXQI@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_8 k59_1249434_2 1121012.AUKX01000041_gene3280 1.51e-14 77.0 COG0265@1|root,COG0265@2|Bacteria,4NFCS@976|Bacteroidetes,1HXT7@117743|Flavobacteriia,23GC6@178469|Arenibacter 976|Bacteroidetes O Trypsin htrA - - - - - - - - - - - PDZ_1,PDZ_2,Trypsin_2 k59_1549152_1 639030.JHVA01000001_gene1777 5.48e-22 94.4 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,3Y2IR@57723|Acidobacteria,2JIMR@204432|Acidobacteriia 204432|Acidobacteriia P Rhodanese-like domain - - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B,Rhodanese k59_772569_1 1033802.SSPSH_003548 2.58e-82 274.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Glutamate synthase gltB GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495,iPC815.YPO3557 GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_358570_1 444860.E3SIZ7_9CAUD 2.54e-47 159.0 4QDYQ@10239|Viruses,4QVVQ@35237|dsDNA viruses no RNA stage,4QPVQ@28883|Caudovirales,4QK1M@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_358570_2 268746.Q58MN3_BPPRM 1.5e-40 147.0 4QDJF@10239|Viruses,4QVQ0@35237|dsDNA viruses no RNA stage,4QR89@28883|Caudovirales,4QICF@10662|Myoviridae 10662|Myoviridae S Virus neck protein - GO:0005575,GO:0019012 - - - - - - - - - - - k59_1456759_1 330214.NIDE3587 1.23e-101 322.0 COG3850@1|root,COG4191@1|root,COG3850@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K07638 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA,PAS_9,PilJ,Response_reg,SpoIIE k59_306644_1 1123487.KB892865_gene1375 3.05e-67 214.0 28MVD@1|root,2ZB2Y@2|Bacteria,1R8NK@1224|Proteobacteria,2VPRP@28216|Betaproteobacteria,2KZJK@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF4043) - - - - - - - - - - - - DUF4043 k59_564317_1 15368.BRADI5G13190.1 5.06e-42 154.0 COG0046@1|root,KOG1907@2759|Eukaryota,37IK9@33090|Viridiplantae,3GFB1@35493|Streptophyta,3KPKM@4447|Liliopsida,3IATH@38820|Poales 35493|Streptophyta F CobB/CobQ-like glutamine amidotransferase domain - GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0007275,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009555,GO:0009570,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0030554,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0048229,GO:0048856,GO:0055046,GO:0097159,GO:0097367,GO:1901265,GO:1901363 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_616499_1 29760.VIT_14s0108g01110.t01 2.05e-58 197.0 COG0626@1|root,KOG0053@2759|Eukaryota,37K09@33090|Viridiplantae,3G79I@35493|Streptophyta 35493|Streptophyta E Cystathionine gamma-synthase - GO:0000096,GO:0000097,GO:0001887,GO:0003674,GO:0003824,GO:0003962,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48 ko:K01739 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00420,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_616500_2 1283300.ATXB01000001_gene1058 1.62e-72 234.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1XFDA@135618|Methylococcales 135618|Methylococcales U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SDF k59_1142755_1 153948.NAL212_1038 2.01e-73 234.0 COG3211@1|root,COG3211@2|Bacteria,1QY0R@1224|Proteobacteria,2VQ88@28216|Betaproteobacteria,372BK@32003|Nitrosomonadales 28216|Betaproteobacteria S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839,PD40 k59_1186515_1 521719.ATXQ01000004_gene1739 4.31e-96 294.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1YEP0@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 CBS,IMPDH,NMO k59_251413_1 1280694.AUJQ01000001_gene2308 1.04e-08 59.3 COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,3NGUJ@46205|Pseudobutyrivibrio 186801|Clostridia LU DNA recombination-mediator protein A dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_251413_2 1121957.ATVL01000008_gene4286 4.15e-139 409.0 COG1004@1|root,COG1004@2|Bacteria,4NE00@976|Bacteroidetes,47KAG@768503|Cytophagia 976|Bacteroidetes M Belongs to the UDP-glucose GDP-mannose dehydrogenase family ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1549242_1 445686.E3SKU6_9CAUD 1.48e-09 57.4 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_409588_1 465515.Mlut_00330 2.01e-08 60.5 COG0654@1|root,COG0654@2|Bacteria,2GXK6@201174|Actinobacteria,1W8JB@1268|Micrococcaceae 201174|Actinobacteria CH FAD binding domain - - - - - - - - - - - - FAD_binding_3 k59_564383_1 1123261.AXDW01000009_gene122 7.3e-27 112.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RSI4@1236|Gammaproteobacteria,1XD7U@135614|Xanthomonadales 135614|Xanthomonadales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4 k59_564383_2 869213.JCM21142_72629 0.000252 42.7 COG3437@1|root,COG3437@2|Bacteria 2|Bacteria T response regulator, receiver - - - - - - - - - - - - GAF_2,GGDEF,HATPase_c,HisKA,PAS,PAS_4,Response_reg k59_1188124_1 717605.Theco_2968 1.34e-19 93.2 COG1251@1|root,COG1251@2|Bacteria,1TQYX@1239|Firmicutes,4HASM@91061|Bacilli,26U3C@186822|Paenibacillaceae 91061|Bacilli C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family nirB - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_1399823_1 436308.Nmar_0109 6.26e-101 302.0 COG1537@1|root,arCOG01741@2157|Archaea,41S6V@651137|Thaumarchaeota 651137|Thaumarchaeota J May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity pelA - - ko:K06965 ko03015,map03015 - - - ko00000,ko00001 - - - eRF1_1,eRF1_3 k59_1607315_1 748247.AZKH_1502 4.45e-31 121.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,2KUWF@206389|Rhodocyclales 28216|Betaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_618215_1 270374.MELB17_13941 1.72e-121 358.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,4642I@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iSDY_1059.SDY_2368 Seryl_tRNA_N,tRNA-synt_2b k59_1399836_1 1392489.JPOL01000002_gene756 1.61e-16 87.0 COG2035@1|root,COG2035@2|Bacteria,4NDU1@976|Bacteroidetes,1HYB3@117743|Flavobacteriia,2XI6S@283735|Leeuwenhoekiella 976|Bacteroidetes S Domain of unknown function (DUF368) - - - - - - - - - - - - DUF368 k59_618217_1 68170.KL590510_gene7215 1.15e-83 252.0 COG3647@1|root,COG3647@2|Bacteria,2IATE@201174|Actinobacteria,4E3YF@85010|Pseudonocardiales 201174|Actinobacteria S Predicted membrane protein (DUF2238) - - - ko:K08984 - - - - ko00000 - - - DUF2238 k59_1550794_1 1121937.AUHJ01000008_gene2131 7.77e-83 266.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,464Q0@72275|Alteromonadaceae 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - iECNA114_1301.ECNA114_3794,iECOK1_1307.ECOK1_4092,iECP_1309.ECP_3748,iECS88_1305.ECS88_4065,iECSF_1327.ECSF_3486,iLF82_1304.LF82_2165,iNRG857_1313.NRG857_18145,iUMN146_1321.UM146_18405,iUTI89_1310.UTI89_C4195,ic_1306.c4475 ACT_4,HD_4,RelA_SpoT,TGS k59_773830_1 498211.CJA_2067 6.03e-31 118.0 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,1RP3R@1236|Gammaproteobacteria,1FGAS@10|Cellvibrio 1236|Gammaproteobacteria O Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678 - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736 Cytochrom_C_asm k59_152196_1 472759.Nhal_3538 1.6e-64 202.0 COG1515@1|root,COG1515@2|Bacteria,1MWRN@1224|Proteobacteria,1RRYH@1236|Gammaproteobacteria,1X059@135613|Chromatiales 135613|Chromatiales L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA nfi - 3.1.21.7 ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 k59_152196_2 3880.AET04349 1.22e-05 49.3 2CMBS@1|root,2QPX1@2759|Eukaryota,37TPJ@33090|Viridiplantae,3GI64@35493|Streptophyta,4JNXW@91835|fabids 35493|Streptophyta S Cyclic phosphodiesterase-like - GO:0000394,GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008081,GO:0008150,GO:0008152,GO:0008380,GO:0009117,GO:0009187,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0019637,GO:0034470,GO:0034641,GO:0034660,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0090304,GO:1901360 - - - - - - - - - - 2_5_RNA_ligase2,CPDase k59_252709_1 1333507.AUTQ01000261_gene3825 5.07e-23 98.2 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_252709_2 1122201.AUAZ01000019_gene1754 3.34e-49 172.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,4658N@72275|Alteromonadaceae 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0031224,GO:0031226,GO:0034641,GO:0036094,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - iEcE24377_1341.EcE24377A_1810 AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_981895_1 273068.TTE1323 1.04e-50 169.0 COG1994@1|root,COG1994@2|Bacteria,1V6D4@1239|Firmicutes,24K0D@186801|Clostridia,42FD9@68295|Thermoanaerobacterales 186801|Clostridia S PFAM peptidase M50 ywhC - - - - - - - - - - - Peptidase_M50 k59_724750_1 1049564.TevJSym_ab00830 1.89e-56 186.0 COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,1S4KI@1236|Gammaproteobacteria,1J6WH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_724750_2 999611.KI421504_gene3292 1.97e-18 87.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1PH2S@1224|Proteobacteria,2U3MS@28211|Alphaproteobacteria,27ZK8@191028|Leisingera 28211|Alphaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - Guanylate_cyc,TPR_16,TPR_2 k59_308172_1 153948.NAL212_0428 1.35e-80 249.0 COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,2VU4X@28216|Betaproteobacteria,372W6@32003|Nitrosomonadales 28216|Betaproteobacteria S Prolyl oligopeptidase family - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 k59_196191_1 511062.GU3_06210 2.95e-10 59.7 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,1S6BS@1236|Gammaproteobacteria,1Y4EH@135624|Aeromonadales 135624|Aeromonadales J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_196191_2 204669.Acid345_3538 3.03e-44 154.0 COG1702@1|root,COG1702@2|Bacteria,3Y3RM@57723|Acidobacteria,2JI4V@204432|Acidobacteriia 204432|Acidobacteriia T PhoH-like protein - - - ko:K06217 - - - - ko00000 - - - PhoH k59_618238_1 247490.KSU1_D0510 1.25e-39 152.0 COG1957@1|root,COG3204@1|root,COG1957@2|Bacteria,COG3204@2|Bacteria 2|Bacteria L pilus organization - - - ko:K02674,ko:K07004 - - - - ko00000,ko02035,ko02044 - - - DUF547,LTD,Laminin_G_3 k59_879240_1 627192.SLG_20100 5.67e-15 75.5 COG5517@1|root,COG5517@2|Bacteria 2|Bacteria Q oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor - - - - - - - - - - - - SnoaL_4 k59_981916_1 323848.Nmul_A0189 2.62e-44 152.0 COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,2VSAZ@28216|Betaproteobacteria,372Z1@32003|Nitrosomonadales 28216|Betaproteobacteria S SURF1-like protein surf1 - - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 k59_879244_1 1453501.JELR01000002_gene349 1.67e-44 164.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,46DC5@72275|Alteromonadaceae 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_773855_1 1237149.C900_05696 2.76e-65 218.0 COG1520@1|root,COG1520@2|Bacteria,4NMP7@976|Bacteroidetes 976|Bacteroidetes S PQQ-like domain - - - - - - - - - - - - PQQ_2 k59_1188175_1 1123261.AXDW01000003_gene1813 8.04e-33 118.0 COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,1S61I@1236|Gammaproteobacteria,1X6FE@135614|Xanthomonadales 135614|Xanthomonadales J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_565614_1 1380391.JIAS01000011_gene4626 1.23e-76 236.0 COG0561@1|root,COG0561@2|Bacteria,1R4WX@1224|Proteobacteria,2TSDR@28211|Alphaproteobacteria,2JVQ8@204441|Rhodospirillales 204441|Rhodospirillales S haloacid dehalogenase-like hydrolase - - - - - - - - - - - - Hydrolase_3 k59_152241_1 1226994.AMZB01000030_gene35 3.49e-05 43.9 COG4736@1|root,COG4736@2|Bacteria,1NGAN@1224|Proteobacteria,1SGJ2@1236|Gammaproteobacteria,1YGZF@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria O Cbb3-type cytochrome oxidase component FixQ ccoQ - - ko:K00407 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixQ k59_152241_2 1211114.ALIP01000091_gene2876 6.79e-44 148.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,1RPU6@1236|Gammaproteobacteria,1X3EF@135614|Xanthomonadales 135614|Xanthomonadales C COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit - - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_773857_1 1033802.SSPSH_002143 1.13e-48 171.0 COG1073@1|root,COG1073@2|Bacteria,1PQAX@1224|Proteobacteria,1RZIS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S alpha beta - - - - - - - - - - - - Peptidase_S9 k59_981931_1 436308.Nmar_1039 3.16e-79 238.0 COG1676@1|root,arCOG01701@2157|Archaea,41SHW@651137|Thaumarchaeota 651137|Thaumarchaeota L tRNA intron endonuclease, N-terminal domain - - 4.6.1.16 ko:K01170 - - - - ko00000,ko01000,ko03016 - - - tRNA_int_endo,tRNA_int_endo_N k59_27277_1 396588.Tgr7_0842 3.2e-101 308.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1WWQM@135613|Chromatiales 135613|Chromatiales P CBS domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1619216_1 349521.HCH_05427 3.23e-11 62.4 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria,1XI25@135619|Oceanospirillales 135619|Oceanospirillales M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_1619216_2 349521.HCH_05426 3.35e-31 123.0 COG4773@1|root,COG4773@2|Bacteria,1QWRF@1224|Proteobacteria,1RN9A@1236|Gammaproteobacteria,1XHTP@135619|Oceanospirillales 135619|Oceanospirillales P Receptor - - - - - - - - - - - - - k59_1619263_1 864073.HFRIS_016597 5.35e-18 81.6 COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2VNWD@28216|Betaproteobacteria,478KE@75682|Oxalobacteraceae 28216|Betaproteobacteria G PFAM Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II k59_27377_1 1283300.ATXB01000001_gene2060 3.57e-82 255.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RQBM@1236|Gammaproteobacteria,1XDMJ@135618|Methylococcales 135618|Methylococcales E PFAM Aminotransferase, class I - - - ko:K14261 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_27377_2 330214.NIDE4114 7.13e-09 56.2 COG0440@1|root,COG0460@1|root,COG0440@2|Bacteria,COG0460@2|Bacteria,3J0G1@40117|Nitrospirae 40117|Nitrospirae E Homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_27416_2 545693.BMQ_5159 2.11e-19 87.0 COG0035@1|root,COG0035@2|Bacteria,1TPMT@1239|Firmicutes,4H9Y0@91061|Bacilli,1ZASG@1386|Bacillus 91061|Bacilli F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate upp GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000 - - iSB619.SA_RS11010 UPRTase k59_27425_1 1212548.B381_12643 2.17e-62 218.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1Z0YX@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L helicase lhr GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,HTH_42,Helicase_C k59_27441_1 1049564.TevJSym_an00800 1.78e-62 201.0 28JUY@1|root,2Z9JY@2|Bacteria,1R822@1224|Proteobacteria,1RPY0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_27711_1 867903.ThesuDRAFT_02330 3.07e-76 246.0 COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,3WCFB@538999|Clostridiales incertae sedis 186801|Clostridia M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_27821_1 379066.GAU_1518 2.13e-14 74.7 COG1196@1|root,COG1196@2|Bacteria,1ZU4J@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Zinc finger domain - - - - - - - - - - - - - k59_27821_2 314345.SPV1_08101 0.000203 43.9 COG0268@1|root,COG0268@2|Bacteria 2|Bacteria J rRNA binding rpsT GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_27933_2 1235792.C808_05025 8.23e-23 102.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_28023_1 450851.PHZ_c1130 3.33e-65 211.0 COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,2TSSU@28211|Alphaproteobacteria,2KIC2@204458|Caulobacterales 204458|Caulobacterales I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_28250_1 765912.Thimo_3521 7.09e-44 159.0 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1WW1M@135613|Chromatiales 135613|Chromatiales S ErfK YbiS YcfS YnhG family protein - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_28273_1 1469245.JFBG01000084_gene200 3.87e-20 89.7 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1WX7K@135613|Chromatiales 135613|Chromatiales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_28396_1 338969.Rfer_3727 4.22e-41 142.0 COG1794@1|root,COG1794@2|Bacteria,1MV03@1224|Proteobacteria,2VHS8@28216|Betaproteobacteria,4ADJE@80864|Comamonadaceae 28216|Betaproteobacteria M Asp/Glu/Hydantoin racemase - - 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race k59_28396_2 1121939.L861_15500 1.88e-109 325.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,1XI57@135619|Oceanospirillales 135619|Oceanospirillales M mechanosensitive ion channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix k59_28640_1 545276.KB898727_gene377 4.28e-36 127.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1WWXG@135613|Chromatiales 135613|Chromatiales L PFAM HNH endonuclease - - - - - - - - - - - - HNH_5 k59_28783_1 159087.Daro_3577 7.64e-38 140.0 COG1638@1|root,COG1638@2|Bacteria,1PMWE@1224|Proteobacteria,2VNJI@28216|Betaproteobacteria 28216|Betaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_28799_1 5111.M1VU75 8.04e-07 55.1 COG1028@1|root,KOG1204@2759|Eukaryota,39WU3@33154|Opisthokonta,3NZ6I@4751|Fungi,3QR10@4890|Ascomycota,211Z4@147550|Sordariomycetes,3TGZT@5125|Hypocreales,3G3RE@34397|Clavicipitaceae 4751|Fungi Q Enoyl-(Acyl carrier protein) reductase - GO:0003674,GO:0003824,GO:0004757,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0016651,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0031224,GO:0034311,GO:0034312,GO:0034641,GO:0042558,GO:0042559,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0050664,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.320 ko:K16216 - - - - ko00000,ko01000 - - - adh_short k59_28900_1 56780.SYN_01692 3.63e-33 125.0 COG0204@1|root,COG0204@2|Bacteria,1P3XM@1224|Proteobacteria 1224|Proteobacteria I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase k59_28939_2 684949.ATTJ01000002_gene288 1.04e-21 95.1 COG1246@1|root,COG1246@2|Bacteria,1WMRV@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Belongs to the acetyltransferase family. ArgA subfamily - - - - - - - - - - - - Acetyltransf_1 k59_28989_1 1121456.ATVA01000012_gene2823 4.07e-54 187.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42Q0K@68525|delta/epsilon subdivisions,2WJUW@28221|Deltaproteobacteria,2M8AC@213115|Desulfovibrionales 28221|Deltaproteobacteria L Belongs to the DEAD box helicase family dedA - 3.6.4.13 ko:K03732,ko:K05592 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_29016_1 446470.Snas_5681 2.63e-12 66.6 COG1213@1|root,COG1213@2|Bacteria,2GN1Y@201174|Actinobacteria,4EYFP@85014|Glycomycetales 201174|Actinobacteria M Nucleotidyl transferase - - - - - - - - - - - - NTP_transf_3,NTP_transferase k59_1254421_2 1292034.OR37_02273 8.23e-23 100.0 COG3917@1|root,COG3917@2|Bacteria,1MV6E@1224|Proteobacteria,2TVJ4@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q 2-hydroxychromene-2-carboxylate isomerase - - - - - - - - - - - - DSBA k59_53103_1 247634.GPB2148_756 5.91e-69 224.0 COG0535@1|root,COG0535@2|Bacteria,1NEM7@1224|Proteobacteria 1224|Proteobacteria M radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_418556_1 863365.XHC_1562 2.09e-79 249.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1X2ZB@135614|Xanthomonadales 135614|Xanthomonadales M synthase cfaA - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_1045387_1 436308.Nmar_1493 1.56e-24 94.4 arCOG08641@1|root,arCOG08641@2157|Archaea,41SU7@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1045387_2 1131266.ARWQ01000001_gene1125 4.89e-30 109.0 arCOG10585@1|root,arCOG10585@2157|Archaea,41SW6@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1149864_1 1049564.TevJSym_ac00650 3.02e-81 259.0 COG0589@1|root,COG0589@2|Bacteria 2|Bacteria T AMP binding - - - - - - - - - - - - Usp k59_627720_1 269799.Gmet_3468 1.22e-34 137.0 COG3280@1|root,COG3280@2|Bacteria,1QTVK@1224|Proteobacteria,42MEW@68525|delta/epsilon subdivisions,2WJX1@28221|Deltaproteobacteria,43SW5@69541|Desulfuromonadales 28221|Deltaproteobacteria G Alpha amylase, catalytic domain treY - 5.4.99.15 ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R09995 - ko00000,ko00001,ko00002,ko01000 - GH13 - Alpha-amylase k59_209589_1 756272.Plabr_0568 3.22e-109 354.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2IXKD@203682|Planctomycetes 203682|Planctomycetes E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_314115_1 1123371.ATXH01000010_gene736 4.72e-77 256.0 COG0495@1|root,COG0495@2|Bacteria,2GGX2@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1 k59_1254436_1 713586.KB900536_gene1923 1.91e-95 300.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_993188_1 1232410.KI421424_gene1712 7.57e-40 136.0 COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria,42SX0@68525|delta/epsilon subdivisions,2WP3K@28221|Deltaproteobacteria 28221|Deltaproteobacteria P NADH-ubiquinone oxidoreductase, chain 4L mnhC - - ko:K05567 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Oxidored_q2 k59_418569_3 382464.ABSI01000010_gene3670 1.81e-32 118.0 COG2863@1|root,COG2863@2|Bacteria,46WZQ@74201|Verrucomicrobia,2IW1M@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Cytochrome c - - - - - - - - - - - - Cytochrom_C k59_261904_1 743722.Sph21_2983 2.12e-67 219.0 COG0334@1|root,COG0334@2|Bacteria,4NEBH@976|Bacteroidetes,1IPRA@117747|Sphingobacteriia 976|Bacteroidetes E Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_836511_1 1313265.JNIE01000002_gene753 5.02e-09 58.2 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,2G3RB@200783|Aquificae 200783|Aquificae C Oxaloacetate decarboxylase alpha subunit oadA - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_836511_2 1123326.JFBL01000012_gene92 1.72e-42 152.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2YM87@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_209593_1 469383.Cwoe_4214 2.8e-79 251.0 COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria 201174|Actinobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit - - 6.2.1.18 ko:K15232 ko00720,ko01100,ko01120,ko01200,map00720,map01100,map01120,map01200 M00173 R01322 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2 k59_1410974_1 292415.Tbd_1714 4.39e-43 145.0 COG0735@1|root,COG0735@2|Bacteria,1RH58@1224|Proteobacteria,2VT6I@28216|Betaproteobacteria,1KSD1@119069|Hydrogenophilales 119069|Hydrogenophilales K Ferric uptake regulator family - - - ko:K09826 - - - - ko00000,ko03000 - - - FUR k59_1410974_2 1301098.PKB_4797 1.42e-135 395.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria 1236|Gammaproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0042380,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046490,GO:0048037,GO:0051536,GO:0051538,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - iECIAI1_1343.ECIAI1_0030,iECW_1372.ECW_m0028,iEKO11_1354.EKO11_3884,iEcHS_1320.EcHS_A0031,iEcolC_1368.EcolC_3626,iPC815.YPO0477,iSFV_1184.SFV_0023,iSF_1195.SF0026,iSFxv_1172.SFxv_0027,iS_1188.S0028,iWFL_1372.ECW_m0028,iYL1228.KPN_00024 LYTB k59_366449_1 981384.AEYW01000028_gene4233 2.75e-15 77.8 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2U2E4@28211|Alphaproteobacteria,4NDQ0@97050|Ruegeria 28211|Alphaproteobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_418587_2 1500893.JQNB01000001_gene367 2.61e-36 135.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1X3JZ@135614|Xanthomonadales 135614|Xanthomonadales M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_1254456_2 462590.A9J4Z1_BPPYU 9.15e-17 81.6 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_1202332_1 246197.MXAN_4963 4.95e-32 129.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,42M2G@68525|delta/epsilon subdivisions,2WJ80@28221|Deltaproteobacteria,2YUN7@29|Myxococcales 28221|Deltaproteobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_627761_1 713586.KB900536_gene1528 7.91e-76 239.0 COG4447@1|root,COG4447@2|Bacteria,1NEFN@1224|Proteobacteria 1224|Proteobacteria C Cytochrome c - - - - - - - - - - - - - k59_836542_1 1214101.BN159_2196 1.7e-37 147.0 COG4932@1|root,COG4932@2|Bacteria,2IFAA@201174|Actinobacteria 201174|Actinobacteria M domain protein - - - - - - - - - - - - - k59_1306508_2 1380394.JADL01000004_gene5779 6.5e-130 375.0 COG5285@1|root,COG5285@2|Bacteria,1MWD5@1224|Proteobacteria,2U0FP@28211|Alphaproteobacteria,2JQWR@204441|Rhodospirillales 204441|Rhodospirillales Q Phytanoyl-CoA dioxygenase (PhyH) - - - - - - - - - - - - PhyH k59_1306508_3 301.JNHE01000020_gene3998 7.52e-19 80.5 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1SBAP@1236|Gammaproteobacteria,1YJFW@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_836548_1 762984.HMPREF9445_02961 6.03e-16 84.3 COG0770@1|root,COG0787@1|root,COG0770@2|Bacteria,COG0787@2|Bacteria,4NEXM@976|Bacteroidetes,2FMM3@200643|Bacteroidia,4AK9Q@815|Bacteroidaceae 976|Bacteroidetes M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N,Mur_ligase,Mur_ligase_M k59_157253_1 631362.Thi970DRAFT_04492 4.34e-80 253.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWMG@135613|Chromatiales 135613|Chromatiales L DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlB - 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C k59_1358911_1 243233.MCA0768 9.43e-96 291.0 COG0167@1|root,COG0167@2|Bacteria,1MXER@1224|Proteobacteria,1RRTA@1236|Gammaproteobacteria,1XDK5@135618|Methylococcales 135618|Methylococcales F Catalyzes the conversion of dihydroorotate to orotate - - 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_261946_1 1429851.X548_05530 1.2e-100 301.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1X51T@135614|Xanthomonadales 135614|Xanthomonadales V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_261946_2 1236542.BALM01000010_gene3767 6.04e-38 141.0 COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,1RP16@1236|Gammaproteobacteria,2QAG0@267890|Shewanellaceae 1236|Gammaproteobacteria M HlyD family secretion protein - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3 k59_366477_1 75379.Tint_0796 8.54e-18 87.4 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2VIFT@28216|Betaproteobacteria,1KIY9@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine rimN - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - SUA5,Sua5_yciO_yrdC k59_366477_2 1303518.CCALI_02313 2.04e-10 61.6 COG4198@1|root,COG4198@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF1015 k59_1097695_1 697282.Mettu_0052 4.07e-11 64.3 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1XE33@135618|Methylococcales 135618|Methylococcales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_53194_1 1178825.ALIH01000006_gene1569 7.92e-07 56.2 COG0845@1|root,COG0845@2|Bacteria,4NF23@976|Bacteroidetes,1HZGV@117743|Flavobacteriia 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_314187_1 926550.CLDAP_33370 4.36e-09 62.4 COG0500@1|root,COG2226@2|Bacteria,2G948@200795|Chloroflexi 200795|Chloroflexi Q Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11 k59_627799_1 247633.GP2143_13661 2.13e-46 157.0 COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria,1RRYS@1236|Gammaproteobacteria,1J6RV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P ZIP Zinc transporter - - - ko:K16267 - - - - ko00000,ko02000 2.A.5.4.11 - - Zip k59_314189_2 1192034.CAP_7928 0.000172 47.4 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,42RV8@68525|delta/epsilon subdivisions,2WKU0@28221|Deltaproteobacteria,2YVHZ@29|Myxococcales 28221|Deltaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_784489_2 1265503.KB905161_gene3128 1.86e-17 87.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,1RNUB@1236|Gammaproteobacteria,2Q6QB@267889|Colwelliaceae 1236|Gammaproteobacteria M Mechanosensitive ion channel ynaI - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_944157_1 1411685.U062_01393 2.62e-24 105.0 COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria,1J6FD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S SURF1-like protein surf1 - - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 k59_944157_2 1163617.SCD_n02655 2.82e-10 60.1 COG1999@1|root,COG1999@2|Bacteria,1RHK3@1224|Proteobacteria,2VRBY@28216|Betaproteobacteria 28216|Betaproteobacteria S signal sequence binding sco1 - - - - - - - - - - - - k59_1049032_2 555079.Toce_1352 4.69e-43 146.0 COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,42GU7@68295|Thermoanaerobacterales 186801|Clostridia J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yrrK - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_1414463_1 563192.HMPREF0179_01647 1.2e-29 119.0 COG0601@1|root,COG0601@2|Bacteria,1NS80@1224|Proteobacteria,42N5D@68525|delta/epsilon subdivisions,2WIRR@28221|Deltaproteobacteria,2M81K@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1258874_1 4081.Solyc07g019510.2.1 3.71e-16 85.1 COG0843@1|root,KOG4769@2759|Eukaryota,37QZZ@33090|Viridiplantae,3GEEJ@35493|Streptophyta,44THR@71274|asterids 35493|Streptophyta C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016310,GO:0017144,GO:0019637,GO:0019646,GO:0019693,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034220,GO:0034641,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901360,GO:1901564,GO:1902600 1.9.3.1 ko:K02256 ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016 M00154 - - ko00000,ko00001,ko00002,ko01000,ko03029 3.D.4.11,3.D.4.7,3.D.4.8 - - COX1 k59_996338_1 765910.MARPU_16675 9.83e-20 88.6 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1WWAT@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_996338_2 1535422.ND16A_0111 2.34e-35 131.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,2Q5U4@267889|Colwelliaceae 1236|Gammaproteobacteria D Peptidoglycan polymerase that is essential for cell wall elongation mrdB GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0016020,GO:0022603,GO:0022604,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_1414465_1 196162.Noca_3306 1.44e-70 230.0 COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4DPFV@85009|Propionibacteriales 201174|Actinobacteria EH TPP binding domain protein - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1414465_2 502025.Hoch_4217 4.71e-175 515.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2YXS2@29|Myxococcales 28221|Deltaproteobacteria C Malic enzyme, NAD binding domain maeB - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1637 Malic_M,PTA_PTB,malic k59_474131_1 357804.Ping_3709 1.5e-64 210.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,2QJ8J@267894|Psychromonadaceae 1236|Gammaproteobacteria V MacB-like periplasmic core domain VP1997 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_788776_2 1122214.AQWH01000017_gene4611 1.6e-43 150.0 COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria 28211|Alphaproteobacteria P 4,5-dihydroxyphthalate decarboxylase - - 4.1.1.55 ko:K04102 ko00624,ko01100,ko01120,map00624,map01100,map01120 M00623 R01635,R05375 RC00390 ko00000,ko00001,ko00002,ko01000 - - - NMT1 k59_1571032_1 305700.B447_07137 3.75e-264 739.0 COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2VJEQ@28216|Betaproteobacteria,2KUQ3@206389|Rhodocyclales 206389|Rhodocyclales G BT1 family - - - - - - - - - - - - BT1 k59_422204_1 1125863.JAFN01000001_gene1123 7.19e-59 197.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_788786_1 1121920.AUAU01000013_gene1728 2.55e-55 195.0 COG3696@1|root,COG3696@2|Bacteria,3Y3AQ@57723|Acidobacteria 57723|Acidobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787,ko:K15726 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 - - ACR_tran k59_108346_2 426355.Mrad2831_1416 7.97e-36 128.0 2DMJ8@1|root,32RY9@2|Bacteria,1RD1Q@1224|Proteobacteria,2U7AU@28211|Alphaproteobacteria,1JUPF@119045|Methylobacteriaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - Rho_N k59_1258897_1 261292.Nit79A3_2996 3.87e-116 353.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2VHH8@28216|Betaproteobacteria,371ZT@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_57522_2 247634.GPB2148_1679 1.23e-48 168.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1S468@1236|Gammaproteobacteria,1J8U1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_dimr,Lactamase_B k59_1309957_1 247634.GPB2148_1662 1.73e-11 66.2 COG2271@1|root,COG2271@2|Bacteria,1MXUC@1224|Proteobacteria,1RRF8@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_265541_1 1121405.dsmv_1305 4.13e-51 182.0 COG4191@1|root,COG4191@2|Bacteria,1QU7R@1224|Proteobacteria,43BS1@68525|delta/epsilon subdivisions,2X72V@28221|Deltaproteobacteria,2MPJD@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA k59_265541_2 335543.Sfum_2092 3.3e-24 102.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MRFD@213462|Syntrophobacterales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_893180_3 436308.Nmar_0750 5.28e-23 90.1 arCOG10541@1|root,arCOG10541@2157|Archaea,41T8Z@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1102071_1 1269813.ATUL01000002_gene824 4.23e-147 443.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1WXPB@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_736200_1 396588.Tgr7_0832 7.13e-107 328.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1WWHQ@135613|Chromatiales 135613|Chromatiales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_318817_1 1049564.TevJSym_ac00580 2.18e-41 152.0 COG2010@1|root,COG2010@2|Bacteria,1R28S@1224|Proteobacteria,1T5JD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 k59_318817_2 547144.HydHO_0819 2.47e-22 95.1 COG2010@1|root,COG2010@2|Bacteria,2G55S@200783|Aquificae 200783|Aquificae C Cytochrome c class I - - - - - - - - - - - - Cytochrome_CBB3 k59_160128_1 1238182.C882_1059 5.67e-81 258.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,2JPV0@204441|Rhodospirillales 204441|Rhodospirillales S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_789667_1 312153.Pnuc_1295 2.23e-17 86.7 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2VHJ8@28216|Betaproteobacteria,1K251@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_893192_1 870187.Thini_4044 3.52e-27 109.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,46070@72273|Thiotrichales 72273|Thiotrichales E PFAM Aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 k59_893192_2 443598.AUFA01000030_gene5904 1.23e-07 52.4 COG2259@1|root,COG2259@2|Bacteria,1PNBS@1224|Proteobacteria,2VCZ0@28211|Alphaproteobacteria,3JY05@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S SURF4 family - - - ko:K15977 - - - - ko00000 - - - DoxX k59_1415326_1 2340.JV46_18900 1.24e-68 210.0 COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,1S343@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Pfam Rhodanese-like - - - - - - - - - - - - Rhodanese k59_579578_1 502025.Hoch_6864 2.88e-65 217.0 COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,42NAD@68525|delta/epsilon subdivisions,2WKEY@28221|Deltaproteobacteria,2Z1IJ@29|Myxococcales 28221|Deltaproteobacteria E PFAM peptidase M3A and M3B thimet oligopeptidase F pepF - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_579578_2 481448.Minf_1623 1.57e-88 275.0 COG1611@1|root,COG1611@2|Bacteria,46SEG@74201|Verrucomicrobia,37G67@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_1207757_1 1208323.B30_18237 3.7e-53 179.0 COG2267@1|root,COG2267@2|Bacteria 2|Bacteria I carboxylic ester hydrolase activity - - 4.2.99.20 ko:K08680 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08166 RC02148,RC02475 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 k59_1207757_2 1125863.JAFN01000001_gene1478 3.99e-42 151.0 29X8P@1|root,30IY2@2|Bacteria,1PV7F@1224|Proteobacteria,42YEW@68525|delta/epsilon subdivisions,2WTQ8@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_422887_1 765911.Thivi_4083 5.77e-162 476.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1WX02@135613|Chromatiales 135613|Chromatiales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_266264_1 330214.NIDE2825 6.91e-126 375.0 COG2804@1|root,COG2804@2|Bacteria,3J0XR@40117|Nitrospirae 2|Bacteria NU Type II/IV secretion system protein gspE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_422891_1 95619.PM1_0209375 5.13e-86 259.0 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria 1236|Gammaproteobacteria H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_2376 Methyltransf_23 k59_58441_2 9365.XP_007532208.1 4.43e-27 109.0 COG1249@1|root,KOG0405@2759|Eukaryota,39J8D@33154|Opisthokonta,3BDB0@33208|Metazoa,3D06N@33213|Bilateria,482J2@7711|Chordata,48UWV@7742|Vertebrata,3J217@40674|Mammalia 33208|Metazoa Q Glutathione reductase GSR GO:0000003,GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0002931,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0006091,GO:0006139,GO:0006518,GO:0006575,GO:0006725,GO:0006749,GO:0006790,GO:0006807,GO:0006950,GO:0006979,GO:0007276,GO:0007283,GO:0007568,GO:0007584,GO:0008150,GO:0008152,GO:0009055,GO:0009605,GO:0009636,GO:0009897,GO:0009986,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0014823,GO:0015036,GO:0015037,GO:0015038,GO:0015949,GO:0016020,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018996,GO:0019953,GO:0022404,GO:0022414,GO:0022900,GO:0031667,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0033189,GO:0033218,GO:0033273,GO:0033554,GO:0033993,GO:0034599,GO:0034641,GO:0035094,GO:0036094,GO:0042221,GO:0042277,GO:0042303,GO:0042395,GO:0042493,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043295,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044703,GO:0045471,GO:0046483,GO:0046677,GO:0046686,GO:0046983,GO:0048037,GO:0048232,GO:0048609,GO:0050660,GO:0050661,GO:0050662,GO:0050896,GO:0051186,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0070013,GO:0070887,GO:0071704,GO:0071944,GO:0072341,GO:0097159,GO:0097237,GO:0097305,GO:0098552,GO:0098622,GO:0098754,GO:0098869,GO:1900750,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901681,GO:1901700,GO:1990748 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_422896_1 1540257.JQMW01000013_gene836 5.24e-25 102.0 COG0320@1|root,COG0320@2|Bacteria,1TQM4@1239|Firmicutes,2495Q@186801|Clostridia,36FJZ@31979|Clostridiaceae 186801|Clostridia H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_579589_2 396588.Tgr7_0997 2.93e-63 215.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WWQ6@135613|Chromatiales 135613|Chromatiales CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_1102099_1 1219045.BV98_003942 4.96e-36 133.0 COG2159@1|root,COG2159@2|Bacteria,1P6G6@1224|Proteobacteria,2TU10@28211|Alphaproteobacteria,2KAHF@204457|Sphingomonadales 204457|Sphingomonadales S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1102099_2 1123320.KB889562_gene6786 1.03e-19 89.7 COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria 201174|Actinobacteria E Belongs to the DegT DnrJ EryC1 family - - 1.17.1.1,4.2.1.164 ko:K12452,ko:K13328 ko00520,ko00523,ko01130,map00520,map00523,map01130 M00802 R03391,R03392,R08930 RC00230,RC00704 ko00000,ko00001,ko00002,ko01000 - - - DegT_DnrJ_EryC1 k59_789696_1 292415.Tbd_2287 1.44e-117 342.0 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,2VQQJ@28216|Betaproteobacteria 28216|Betaproteobacteria S Predicted membrane protein (DUF2238) - - - ko:K08984 - - - - ko00000 - - - DUF2238 k59_1468034_1 1828.JOKB01000028_gene2352 5.49e-31 120.0 COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria,4FV3U@85025|Nocardiaceae 201174|Actinobacteria K Belongs to the ParB family parB GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944 - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_266278_1 62928.azo2100 1.36e-76 241.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VKRZ@28216|Betaproteobacteria,2KZSM@206389|Rhodocyclales 206389|Rhodocyclales H Aminotransferase class-III - - 2.6.1.18 ko:K00822 ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100 - R00907,R04187 RC00008,RC00062,RC00160 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_58454_1 649638.Trad_0146 3.63e-26 114.0 COG1957@1|root,COG1957@2|Bacteria 2|Bacteria F ribosylpyrimidine nucleosidase activity - - - - - - - - - - - - IU_nuc_hydro k59_633107_1 590998.Celf_2558 4.82e-89 284.0 COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4F1W1@85016|Cellulomonadaceae 201174|Actinobacteria I Biotin carboxylase C-terminal domain accA1 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 6.3.4.14,6.4.1.2,6.4.1.3 ko:K11263 ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv2501c Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_789708_1 2002.JOEQ01000066_gene7886 1.69e-52 183.0 COG0209@1|root,COG0209@2|Bacteria,2GKX9@201174|Actinobacteria,4EFQ2@85012|Streptosporangiales 201174|Actinobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdJ GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC k59_685233_2 1237149.C900_03200 2.2e-60 208.0 COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,4NE1X@976|Bacteroidetes,47JV4@768503|Cytophagia 976|Bacteroidetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_2680_1 235985.BBPN01000008_gene4108 1.58e-05 46.6 COG1024@1|root,COG1024@2|Bacteria,2GKJ6@201174|Actinobacteria,2NJ8Y@228398|Streptacidiphilus 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - GO:0003674,GO:0003824,GO:0004300,GO:0016829,GO:0016835,GO:0016836 4.2.1.149 ko:K08299,ko:K16426 ko01055,ko01130,map01055,map01130 - R06625,R10675 RC00004,RC01095,RC02933 ko00000,ko00001,ko01000 - - - ECH_1 k59_2680_2 305700.B447_09333 8.83e-104 313.0 COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2VIH8@28216|Betaproteobacteria,2KZ85@206389|Rhodocyclales 206389|Rhodocyclales EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - 1.1.1.79,1.1.1.81 ko:K12972 ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120 - R00465,R01388,R01392,R02527 RC00031,RC00042,RC00670 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_318863_1 1041930.Mtc_1597 3.06e-138 408.0 COG2021@1|root,arCOG00627@2157|Archaea,2XTYY@28890|Euryarchaeota,2N9C1@224756|Methanomicrobia 224756|Methanomicrobia E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metXA - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1,CBS k59_736247_1 479434.Sthe_0452 5.71e-17 87.4 COG1409@1|root,COG1409@2|Bacteria 2|Bacteria S acid phosphatase activity - - - - - - - - - - - - Metallophos k59_1415368_1 115417.EPrPW00000024545 3.2e-29 112.0 COG0494@1|root,2S254@2759|Eukaryota,1MGX7@121069|Pythiales 121069|Pythiales L Source PGD - - - - - - - - - - - - NUDIX k59_1415368_2 1005048.CFU_0805 2.85e-05 47.4 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,2VHV6@28216|Betaproteobacteria,472UW@75682|Oxalobacteraceae 28216|Betaproteobacteria T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH - 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - - Metallophos k59_422917_1 1249627.D779_0893 1.93e-149 440.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1WWKE@135613|Chromatiales 135613|Chromatiales U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_633122_1 998674.ATTE01000001_gene4336 1.44e-94 290.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,45ZPY@72273|Thiotrichales 72273|Thiotrichales E Glutamate synthase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_58471_2 243233.MCA1224 1.13e-46 155.0 COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,1S93F@1236|Gammaproteobacteria,1XFE7@135618|Methylococcales 135618|Methylococcales S Tol-Pal system-associated acyl-CoA thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT k59_58471_3 1163617.SCD_n00673 1.31e-77 240.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2VJPW@28216|Betaproteobacteria 28216|Betaproteobacteria U Mota tolq exbb proton channel tolQ - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_58471_4 1026882.MAMP_00018 5.77e-40 138.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria,46135@72273|Thiotrichales 72273|Thiotrichales U Biopolymer transport protein ExbD TolR tolR - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_475051_1 1095750.HMPREF9970_1318 7.81e-09 60.8 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V1DC@1239|Firmicutes,24GJV@186801|Clostridia,1HUK7@1164882|Lachnoanaerobaculum 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,HTH_AraC,Response_reg k59_475051_2 378806.STAUR_8087 1.75e-10 62.8 COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase pilS - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_1102130_2 522306.CAP2UW1_4287 3.35e-38 141.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2VIIH@28216|Betaproteobacteria 28216|Betaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1624336_1 314287.GB2207_06743 9.58e-145 421.0 COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,1RN4Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Zn-dependent hydrolases of the beta-lactamase fold - - 3.1.4.54 ko:K13985 ko04723,map04723 - - - ko00000,ko00001,ko01000 - - - Lactamase_B_2 k59_1624336_2 745014.OMB55_00019690 3.42e-136 397.0 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,1RNGM@1236|Gammaproteobacteria,1J597@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S NADP-dependent oxidoreductases - - - - - - - - - - - - ADH_N_2,ADH_zinc_N k59_374760_2 309807.SRU_2389 2.1e-10 60.1 COG1833@1|root,COG1833@2|Bacteria,4PF8V@976|Bacteroidetes,1FKAW@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Domain of unknown function DUF123 - - - - - - - - - - - - DUF123 k59_1473038_1 1205680.CAKO01000010_gene3801 2.32e-98 302.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2U2SV@28211|Alphaproteobacteria,2JZPJ@204441|Rhodospirillales 28211|Alphaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_1473038_2 1205680.CAKO01000030_gene4841 3.44e-30 116.0 COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2U1CT@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_479274_1 1121403.AUCV01000026_gene2346 1.4e-66 216.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_270268_1 926560.KE387023_gene2443 5.96e-41 151.0 COG3408@1|root,COG3408@2|Bacteria,1WM3Z@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Alkaline and neutral invertase - - - - - - - - - - - - Glyco_hydro_100 k59_270268_2 1298860.AUEM01000012_gene135 2.79e-18 87.0 COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria,4FMJV@85023|Microbacteriaceae 201174|Actinobacteria GM Protein of unknown function (DUF2867) - - - - - - - - - - - - DUF2867,NAD_binding_10,TspO_MBR k59_1265995_2 204669.Acid345_3783 2.29e-07 51.6 COG2510@1|root,COG2510@2|Bacteria 2|Bacteria EG membrane - - - ko:K08978 - - - - ko00000,ko02000 2.A.7.2 - - EamA k59_1158459_1 436308.Nmar_0410 1.84e-40 140.0 arCOG08666@1|root,arCOG08666@2157|Archaea,41SVR@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_531948_1 472759.Nhal_0923 2.98e-24 102.0 COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1WX1P@135613|Chromatiales 135613|Chromatiales S Cytochrome c assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_1213695_1 330214.NIDE0858 3.19e-94 280.0 COG0745@1|root,COG0745@2|Bacteria,3J0JU@40117|Nitrospirae 40117|Nitrospirae K Transcriptional regulatory protein, C terminal - - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_584213_1 1499967.BAYZ01000184_gene4587 1.05e-183 529.0 COG4122@1|root,COG4122@2|Bacteria,2NQFB@2323|unclassified Bacteria 2|Bacteria S Pup-ligase protein dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 ko:K20814 - - - - ko00000,ko01000,ko03051 - - - Pup_ligase k59_218747_1 396588.Tgr7_0353 4.27e-93 284.0 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales 135613|Chromatiales P Belongs to the sulfate adenylyltransferase family sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_4641_1 472759.Nhal_3435 1.55e-225 629.0 COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,1RRMX@1236|Gammaproteobacteria,1WXC1@135613|Chromatiales 135613|Chromatiales G RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site cbbL - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N k59_796201_1 1342301.JASD01000008_gene2421 8.29e-103 309.0 COG0625@1|root,COG0625@2|Bacteria,1P71B@1224|Proteobacteria,2U1A5@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Glutathione S-transferase - - - - - - - - - - - - GST_C_2,GST_N_3 k59_1001670_1 1165096.ARWF01000001_gene16 9.52e-28 117.0 COG2114@1|root,COG2114@2|Bacteria,1RD0X@1224|Proteobacteria,2VS0D@28216|Betaproteobacteria 28216|Betaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - Guanylate_cyc,PEGA k59_898022_1 713586.KB900536_gene1169 3.67e-69 215.0 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,1WW16@135613|Chromatiales 135613|Chromatiales J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_949452_1 1120973.AQXL01000120_gene862 1.86e-38 147.0 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1TPFH@1239|Firmicutes,4HA07@91061|Bacilli,278SU@186823|Alicyclobacillaceae 91061|Bacilli F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_1367956_1 869210.Marky_0954 1.05e-148 432.0 COG0065@1|root,COG0065@2|Bacteria,1WIIS@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_1420454_1 251221.35211732 3.33e-117 360.0 COG1452@1|root,COG1452@2|Bacteria,1G0TW@1117|Cyanobacteria 1117|Cyanobacteria M PFAM Mannosyl oligosaccharide glucosidase - - - - - - - - - - - - Glyco_hydro_63 k59_480355_1 204669.Acid345_1620 1.34e-66 210.0 COG1136@1|root,COG1136@2|Bacteria,3Y4A6@57723|Acidobacteria,2JMVQ@204432|Acidobacteriia 204432|Acidobacteriia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_480355_2 1283300.ATXB01000001_gene38 7.81e-13 69.7 COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,1RPZF@1236|Gammaproteobacteria 1236|Gammaproteobacteria V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1474095_3 1173026.Glo7428_3182 1.02e-09 60.1 COG1430@1|root,COG1430@2|Bacteria,1G6N9@1117|Cyanobacteria 1117|Cyanobacteria S acr, cog1430 - - - ko:K09005 - - - - ko00000 - - - DUF192 k59_1106992_1 1356852.N008_12955 6.39e-18 81.6 COG0494@1|root,COG0494@2|Bacteria,4NM6C@976|Bacteroidetes,47MQZ@768503|Cytophagia 976|Bacteroidetes L pfam nudix - - - - - - - - - - - - NUDIX k59_1106992_2 322710.Avin_19150 2.1e-57 195.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,1T1W9@1236|Gammaproteobacteria 1236|Gammaproteobacteria V COG5265 ABC-type transport system involved in Fe-S cluster assembly permease and ATPase components atmA - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1158482_1 338963.Pcar_0675 6.49e-61 198.0 COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,42NK5@68525|delta/epsilon subdivisions,2WJ49@28221|Deltaproteobacteria,43S5K@69541|Desulfuromonadales 28221|Deltaproteobacteria H PBP superfamily domain tupA - - ko:K05772 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - PBP_like_2 k59_1158482_2 1026882.MAMP_01989 3e-57 198.0 COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,1T1HJ@1236|Gammaproteobacteria,45ZN4@72273|Thiotrichales 72273|Thiotrichales P Sodium/hydrogen exchanger family - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger,TrkA_N k59_796233_1 56780.SYN_00618 4.49e-28 112.0 COG2043@1|root,COG2043@2|Bacteria,1R8EH@1224|Proteobacteria,42Q2F@68525|delta/epsilon subdivisions,2WJZN@28221|Deltaproteobacteria,2MQKY@213462|Syntrophobacterales 28221|Deltaproteobacteria S Uncharacterised ArCR, COG2043 - - - - - - - - - - - - DUF169 k59_1420473_1 706587.Desti_0688 6.08e-92 280.0 COG0167@1|root,COG1148@1|root,COG0167@2|Bacteria,COG1148@2|Bacteria,1MXER@1224|Proteobacteria,42QNP@68525|delta/epsilon subdivisions,2X5RV@28221|Deltaproteobacteria 68525|delta/epsilon subdivisions CF Dihydroorotate dehydrogenase - - 1.3.1.1,1.3.98.1 ko:K00226,ko:K17723 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046,M00051 R00977,R01414,R01867,R11026 RC00051,RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_480375_1 143224.JQMD01000002_gene2636 3.2e-28 117.0 COG4857@1|root,COG4857@2|Bacteria,4NHKI@976|Bacteroidetes,1I08V@117743|Flavobacteriia 976|Bacteroidetes S Phosphotransferase enzyme family mtnK - 2.7.1.100 ko:K00899 ko00270,ko01100,map00270,map01100 M00034 R04143 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APH k59_740924_1 47763.JNZA01000015_gene751 5.9e-13 73.6 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_1054671_1 515635.Dtur_1490 1.77e-30 122.0 COG0162@1|root,COG0162@2|Bacteria 2|Bacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iJN746.PP_0436,iLJ478.TM0478 S4,tRNA-synt_1b k59_531989_1 649747.HMPREF0083_06174 4.12e-91 296.0 COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1TPU5@1239|Firmicutes,4HCZG@91061|Bacilli,26VQ9@186822|Paenibacillaceae 91061|Bacilli I COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) hgdC - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_1315221_1 1220534.B655_0695 5.92e-37 134.0 COG1260@1|root,arCOG04213@2157|Archaea,2XVGK@28890|Euryarchaeota,23NU3@183925|Methanobacteria 183925|Methanobacteria I myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth k59_1420482_1 443144.GM21_3519 1.32e-10 63.5 COG0755@1|root,COG0755@2|Bacteria,1RG6M@1224|Proteobacteria,43BH8@68525|delta/epsilon subdivisions,2X6VM@28221|Deltaproteobacteria,43TB0@69541|Desulfuromonadales 28221|Deltaproteobacteria O PFAM cytochrome c assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_690734_2 1123360.thalar_02888 7.73e-57 196.0 COG1145@1|root,COG1290@1|root,COG1908@1|root,COG1145@2|Bacteria,COG1290@2|Bacteria,COG1908@2|Bacteria,1QSPU@1224|Proteobacteria,2UQID@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - Cytochrome_B,FlpD k59_949481_1 1163617.SCD_n00974 1.15e-39 154.0 COG1729@1|root,COG1729@2|Bacteria,1MZ7N@1224|Proteobacteria,2VNYC@28216|Betaproteobacteria 28216|Betaproteobacteria S Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - - - - - - - - - - - k59_1001706_1 622637.KE124774_gene3134 4.62e-76 254.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2TR6F@28211|Alphaproteobacteria,36XW3@31993|Methylocystaceae 28211|Alphaproteobacteria C Phosphoenolpyruvate carboxylase ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_531997_1 631362.Thi970DRAFT_00706 2.92e-24 106.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_8 k59_271163_1 83406.HDN1F_28420 7.31e-12 65.5 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1J4J1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Cytochrome c-type biogenesis protein ccmF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_271163_2 420662.Mpe_A1210 1.19e-44 150.0 COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2VR8D@28216|Betaproteobacteria,1KKN4@119065|unclassified Burkholderiales 28216|Betaproteobacteria CO Periplasmic protein thiol dsbE - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA,Redoxin k59_1001712_1 1144305.PMI02_00182 5.11e-23 102.0 COG0438@1|root,COG0438@2|Bacteria,1MVIM@1224|Proteobacteria,2TR88@28211|Alphaproteobacteria,2K0WY@204457|Sphingomonadales 204457|Sphingomonadales M Glycosyl transferase - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4 k59_113620_1 305900.GV64_19500 3.7e-76 238.0 COG0183@1|root,COG0183@2|Bacteria,1NSYR@1224|Proteobacteria,1SJW4@1236|Gammaproteobacteria,1XR8M@135619|Oceanospirillales 135619|Oceanospirillales I Belongs to the thiolase family - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_113620_2 399795.CtesDRAFT_PD1327 2.35e-06 48.9 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2VMR5@28216|Betaproteobacteria,4ABTE@80864|Comamonadaceae 28216|Betaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1576400_1 349521.HCH_02433 4.03e-16 84.0 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1XIW5@135619|Oceanospirillales 135619|Oceanospirillales NU Tfp pilus assembly protein - - - ko:K08086 - - - - ko00000 - - - LysM,TPR_19 k59_584273_1 95619.PM1_0218260 1.16e-77 237.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_845663_1 1335757.SPICUR_00555 1.39e-08 55.5 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales 135613|Chromatiales O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_845663_2 693986.MOC_0691 2.92e-35 123.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2U9AQ@28211|Alphaproteobacteria,1JV6J@119045|Methylobacteriaceae 28211|Alphaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_796273_1 1906.SFRA_25855 1.35e-55 195.0 COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria 201174|Actinobacteria P ATPase P-type (Transporting), HAD superfamily, subfamily IC ctpF GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.8 ko:K01537,ko:K12953 - - - - ko00000,ko01000 3.A.3,3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_584279_1 392499.Swit_1752 4.48e-39 143.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,2K093@204457|Sphingomonadales 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_740947_1 543728.Vapar_6198 5.57e-43 150.0 COG0625@1|root,COG0625@2|Bacteria,1RHXQ@1224|Proteobacteria,2W2WE@28216|Betaproteobacteria 28216|Betaproteobacteria O glutathione transferase activity - - - - - - - - - - - - - k59_1420511_1 1036674.A28LD_1483 1.77e-37 129.0 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,1S9EI@1236|Gammaproteobacteria,2QGI2@267893|Idiomarinaceae 1236|Gammaproteobacteria L Transposase lcrS - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_1420511_2 717772.THIAE_05850 8.67e-89 270.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,1SY22@1236|Gammaproteobacteria,462Q2@72273|Thiotrichales 72273|Thiotrichales L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - rve_3 k59_1315248_1 323848.Nmul_A0925 6.4e-132 400.0 COG0845@1|root,COG1994@1|root,COG0845@2|Bacteria,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,2VIUH@28216|Betaproteobacteria 28216|Betaproteobacteria M membrane-associated Zn-dependent proteases 1 - - - ko:K16922 - - - - ko00000,ko01002 - - - PqqD k59_1315251_1 436308.Nmar_1698 2.87e-75 238.0 COG0004@1|root,arCOG04397@2157|Archaea,41SY0@651137|Thaumarchaeota 651137|Thaumarchaeota P Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_1315251_2 1229909.NSED_09030 7.83e-26 101.0 COG2897@1|root,arCOG02019@2157|Archaea,41SXR@651137|Thaumarchaeota 651137|Thaumarchaeota P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_64841_2 330214.NIDE0561 1.19e-47 164.0 COG0535@1|root,COG0535@2|Bacteria,3J10V@40117|Nitrospirae 40117|Nitrospirae C Iron-sulfur cluster-binding domain - - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM k59_64847_2 1303518.CCALI_00763 3.13e-40 150.0 COG1196@1|root,COG1196@2|Bacteria 2|Bacteria D nuclear chromosome segregation smc GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1266113_1 96561.Dole_0221 1.58e-64 224.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MICN@213118|Desulfobacterales 28221|Deltaproteobacteria G Pyruvate phosphate dikinase, PEP - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_1521485_1 1122134.KB893650_gene243 2.13e-35 135.0 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria,1XIR3@135619|Oceanospirillales 135619|Oceanospirillales H biosynthesis protein HemY hemY - - ko:K02498 - - - - ko00000 - - - HemY_N,TPR_7 k59_113656_2 589865.DaAHT2_1325 1.07e-40 142.0 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,42SN2@68525|delta/epsilon subdivisions,2WP0X@28221|Deltaproteobacteria,2MPUR@213118|Desulfobacterales 28221|Deltaproteobacteria S haloacid dehalogenase-like hydrolase kdsC - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 k59_845692_1 1121434.AULY01000006_gene929 2.21e-86 285.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,43C4Y@68525|delta/epsilon subdivisions,2X7FA@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_64868_2 1123242.JH636435_gene3007 2.35e-18 83.6 COG2172@1|root,COG2172@2|Bacteria,2J0BZ@203682|Planctomycetes 203682|Planctomycetes T COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase) - - 2.7.11.1 ko:K04757 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2 k59_64868_3 1379270.AUXF01000006_gene75 1.24e-25 98.2 COG1366@1|root,COG1366@2|Bacteria,1ZTXM@142182|Gemmatimonadetes 142182|Gemmatimonadetes T STAS domain - - - ko:K04749 - - - - ko00000,ko03021 - - - STAS k59_1054735_1 926550.CLDAP_23740 2.12e-49 168.0 COG1218@1|root,COG1218@2|Bacteria 2|Bacteria P 3'(2'),5'-bisphosphate nucleotidase activity cysQ - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_1001764_1 765420.OSCT_1210 3.9e-77 248.0 COG0281@1|root,COG0281@2|Bacteria,2G65R@200795|Chloroflexi,376YS@32061|Chloroflexia 32061|Chloroflexia C Malic enzyme, NAD binding domain - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic k59_1107064_1 667014.Thein_0442 1.87e-10 60.1 COG2001@1|root,COG2001@2|Bacteria,2GGT9@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ k59_1581182_1 864051.BurJ1DRAFT_3123 2.27e-27 114.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1KJN7@119065|unclassified Burkholderiales 28216|Betaproteobacteria F DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_1634606_1 69279.BG36_13835 1.52e-44 157.0 COG1597@1|root,COG1597@2|Bacteria,1RCJT@1224|Proteobacteria,2U7IG@28211|Alphaproteobacteria,43JD5@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I Diacylglycerol kinase - - - - - - - - - - - - DAGK_cat k59_536703_1 1229909.NSED_06905 2.94e-120 363.0 COG3808@1|root,arCOG04949@2157|Archaea,41SZG@651137|Thaumarchaeota 651137|Thaumarchaeota C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_6857_1 349521.HCH_05912 2.47e-75 237.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1XHX5@135619|Oceanospirillales 135619|Oceanospirillales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_1319077_1 1162668.LFE_1838 5.2e-41 140.0 COG5609@1|root,COG5609@2|Bacteria,3J180@40117|Nitrospirae 40117|Nitrospirae S Uncharacterized conserved protein (DUF2294) - - - - - - - - - - - - DUF2294 k59_1524642_1 797209.ZOD2009_20687 1.16e-43 172.0 COG1501@1|root,arCOG03663@2157|Archaea,2XV49@28890|Euryarchaeota,23V0G@183963|Halobacteria 183963|Halobacteria G Melibiase - - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Melibiase k59_1524642_2 1047013.AQSP01000108_gene2063 1.71e-14 70.1 COG1983@1|root,COG1983@2|Bacteria 2|Bacteria KT positive regulation of macromolecule biosynthetic process - - - ko:K03973 - - - - ko00000,ko02048,ko03000 - - - PspC k59_169287_2 519989.ECTPHS_00280 5.41e-44 162.0 28KIX@1|root,2Z9Y0@2|Bacteria,1R427@1224|Proteobacteria,1RRGI@1236|Gammaproteobacteria,1WX2J@135613|Chromatiales 135613|Chromatiales S TIGRFAM Poly(R)-hydroxyalkanoic acid synthase, class III, PhaE subunit - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009058,GO:0016234,GO:0042618,GO:0042619,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0070088,GO:0071704,GO:1901440,GO:1901441,GO:1901576 - - - - - - - - - - PHA_synth_III_E k59_954442_1 396588.Tgr7_0231 3.1e-36 126.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1WY8U@135613|Chromatiales 135613|Chromatiales U general secretion pathway protein G - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_954442_2 572477.Alvin_0107 5.42e-09 55.8 2B7TJ@1|root,32102@2|Bacteria,1RHKS@1224|Proteobacteria,1S7PY@1236|Gammaproteobacteria,1WYNN@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF5063) - - - - - - - - - - - - DUF5063 k59_645781_1 748247.AZKH_3280 4.76e-112 342.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2VKAN@28216|Betaproteobacteria,2KVQH@206389|Rhodocyclales 206389|Rhodocyclales I Acetyl-coenzyme A synthetase N-terminus - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1111820_2 1121448.DGI_2868 1.85e-27 110.0 COG3900@1|root,COG3900@2|Bacteria,1RKQP@1224|Proteobacteria,42US2@68525|delta/epsilon subdivisions,2WQT6@28221|Deltaproteobacteria,2M92G@213115|Desulfovibrionales 28221|Deltaproteobacteria S Predicted periplasmic protein (DUF2092) - - - - - - - - - - - - DUF2092 k59_486969_1 1040987.AZUY01000035_gene4209 2.88e-57 193.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,2TUDG@28211|Alphaproteobacteria,43K9R@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.19 ko:K00823 ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1272558_1 398527.Bphyt_2910 7.9e-103 305.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2VJ3S@28216|Betaproteobacteria,1JZTR@119060|Burkholderiaceae 28216|Betaproteobacteria IQ reductase fabG GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1480545_2 1411123.JQNH01000001_gene743 1.04e-45 165.0 COG0074@1|root,COG0074@2|Bacteria,1MWWN@1224|Proteobacteria,2TTYT@28211|Alphaproteobacteria 28211|Alphaproteobacteria C CoA binding domain - - - - - - - - - - - - CoA_binding,Ligase_CoA k59_695600_1 1469245.JFBG01000016_gene967 1.47e-129 382.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1WWX1@135613|Chromatiales 135613|Chromatiales C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_71130_1 1101192.KB910516_gene2421 1.32e-38 150.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,1JRZ3@119045|Methylobacteriaceae 28211|Alphaproteobacteria M TIGRFAM penicillin-binding protein, 1A family mrcB - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - BA14K,Transgly,Transpeptidase k59_1581215_2 1132855.KB913035_gene1502 4.77e-46 157.0 COG1611@1|root,COG3350@1|root,COG1611@2|Bacteria,COG3350@2|Bacteria,1R8EU@1224|Proteobacteria 1224|Proteobacteria S YHS domain - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - YHS k59_1218500_1 472759.Nhal_3892 2.87e-93 297.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1WWH1@135613|Chromatiales 135613|Chromatiales M TIGRFAM penicillin-binding protein, 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_1272566_1 187272.Mlg_0887 3.79e-37 128.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,1S5XX@1236|Gammaproteobacteria,1WYID@135613|Chromatiales 135613|Chromatiales J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_276043_1 1121456.ATVA01000011_gene1681 1.27e-59 199.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,43CGH@68525|delta/epsilon subdivisions,2WJ3J@28221|Deltaproteobacteria,2M83K@213115|Desulfovibrionales 28221|Deltaproteobacteria EQ PFAM Hydantoinase B oxoprolinase hyuB - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_695611_2 1049564.TevJSym_ax00490 6.85e-45 162.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5F8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_71144_1 1123368.AUIS01000023_gene933 1.44e-20 98.6 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2NDJD@225057|Acidithiobacillales 225057|Acidithiobacillales T Diguanylate cyclase - - - - - - - - - - - - CZB,EAL,GGDEF,PAS,PAS_4 k59_432464_1 323848.Nmul_A0688 3.12e-39 150.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,3727K@32003|Nitrosomonadales 28216|Betaproteobacteria V Hydrophobe amphiphile efflux-1 HAE1 - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_328719_1 1250006.JHZZ01000001_gene1563 5.3e-24 95.5 2CENM@1|root,32S06@2|Bacteria,4NVR4@976|Bacteroidetes,1I5EG@117743|Flavobacteriia,3VWT1@52959|Polaribacter 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1006774_1 396588.Tgr7_3185 2.2e-53 186.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_902891_2 1229204.AMYY01000031_gene752 2.65e-26 104.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2TR3M@28211|Alphaproteobacteria,4BQ20@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L HNH nucleases MA20_20605 - - - - - - - - - - - HNH,HNH_5 k59_1372789_1 1469613.JT55_04590 3.37e-16 78.2 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2U74V@28211|Alphaproteobacteria,3FD6R@34008|Rhodovulum 28211|Alphaproteobacteria T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_589163_1 1415780.JPOG01000001_gene2508 6.96e-72 239.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria,1SMN0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_71161_1 749414.SBI_04700 6.88e-24 105.0 COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria 201174|Actinobacteria I Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_276073_1 330214.NIDE0781 8.11e-41 143.0 COG0462@1|root,COG0462@2|Bacteria,3J0D0@40117|Nitrospirae 40117|Nitrospirae F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_802924_1 953739.SVEN_6198 6.7e-85 264.0 COG0535@1|root,COG0535@2|Bacteria,2ID7T@201174|Actinobacteria 201174|Actinobacteria S radical SAM domain protein - - - - - - - - - - - - Fer4_12,Radical_SAM k59_1272610_1 1499967.BAYZ01000184_gene4576 1.13e-95 303.0 COG0013@1|root,COG0013@2|Bacteria,2NNYC@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD k59_1218544_1 290400.Jann_3107 1.9e-59 191.0 COG1136@1|root,COG1136@2|Bacteria,1RA1K@1224|Proteobacteria,2U7CA@28211|Alphaproteobacteria 28211|Alphaproteobacteria V COG1136 ABC-type antimicrobial peptide transport system ATPase component - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1634686_1 398767.Glov_0537 4.89e-06 54.3 COG0845@1|root,COG0845@2|Bacteria,1MX8W@1224|Proteobacteria,42SYF@68525|delta/epsilon subdivisions,2WPNQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K15727 - - - - ko00000,ko02000 8.A.1.2.1 - - HlyD_D23 k59_1634686_2 1120977.JHUX01000009_gene2603 0.000198 48.5 COG1538@1|root,COG1538@2|Bacteria,1PM0T@1224|Proteobacteria,1S80U@1236|Gammaproteobacteria,3NJYG@468|Moraxellaceae 1236|Gammaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1272616_1 289376.THEYE_A1153 1.52e-13 68.9 COG0115@1|root,COG0115@2|Bacteria,3J0BM@40117|Nitrospirae 40117|Nitrospirae E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_1272616_2 330214.NIDE1102 1.81e-37 129.0 COG0261@1|root,COG0261@2|Bacteria,3J0TM@40117|Nitrospirae 40117|Nitrospirae J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_695638_1 402881.Plav_2680 1.48e-05 52.8 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 k59_536763_1 1120968.AUBX01000017_gene1905 4.51e-09 62.8 COG2812@1|root,COG2812@2|Bacteria,4PKEA@976|Bacteroidetes,47KBY@768503|Cytophagia 976|Bacteroidetes L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_645851_1 585423.KR49_12625 4.56e-08 61.2 COG1266@1|root,COG1266@2|Bacteria,1G0ZJ@1117|Cyanobacteria,1GZ8P@1129|Synechococcus 1117|Cyanobacteria S metal-dependent membrane protease - - - ko:K07052 - - - - ko00000 - - - Abi k59_1272624_1 697282.Mettu_2470 1.01e-99 303.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1XE3Y@135618|Methylococcales 135618|Methylococcales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1218561_1 1235811.HMPREF0653_02090 1.76e-12 65.9 COG0335@1|root,COG0335@2|Bacteria,4NNPW@976|Bacteroidetes,2FSHU@200643|Bacteroidia 976|Bacteroidetes J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_695646_1 754476.Q7A_1353 9.48e-77 246.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,45ZNG@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses nadE - 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_1059735_1 525904.Tter_0324 9.13e-41 146.0 COG0137@1|root,COG0137@2|Bacteria,2NP01@2323|unclassified Bacteria 2|Bacteria E Arginosuccinate synthase argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN678.argG,iSB619.SA_RS04675 Arginosuc_synth k59_1059735_2 1210884.HG799475_gene15215 5.17e-21 100.0 COG0661@1|root,COG0661@2|Bacteria,2IXG0@203682|Planctomycetes 203682|Planctomycetes S unusual protein kinase - - - ko:K03688 - - - - ko00000 - - - ABC1 k59_1581277_1 436308.Nmar_0672 4.9e-86 261.0 COG0492@1|root,arCOG01296@2157|Archaea,41S97@651137|Thaumarchaeota 651137|Thaumarchaeota O Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1426983_1 330214.NIDE1303 4.06e-120 376.0 COG0085@1|root,COG0085@2|Bacteria,3J0CW@40117|Nitrospirae 40117|Nitrospirae K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_487065_1 290397.Adeh_1054 4.77e-28 117.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,2YU71@29|Myxococcales 28221|Deltaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1059744_1 1304872.JAGC01000003_gene3289 1.55e-54 177.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,42N90@68525|delta/epsilon subdivisions,2WJUU@28221|Deltaproteobacteria,2MA2P@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_1218579_1 879309.HMPREF9199_1126 7.81e-38 140.0 COG0773@1|root,COG0773@2|Bacteria,1TQ5H@1239|Firmicutes,4H1VH@909932|Negativicutes 909932|Negativicutes M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N,Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1218579_2 1231377.C426_0481 1.2e-12 68.9 COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,4HAD8@91061|Bacilli,1YB79@1357|Lactococcus 91061|Bacilli M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_119386_2 45351.EDO30161 2.29e-11 65.9 COG1446@1|root,KOG1592@2759|Eukaryota,38JIS@33154|Opisthokonta,3BB1E@33208|Metazoa 33208|Metazoa E asparagine catabolic process via L-aspartate ASRGL1 GO:0003674,GO:0003824,GO:0004067,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006508,GO:0006520,GO:0006528,GO:0006530,GO:0006558,GO:0006559,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008798,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009068,GO:0009072,GO:0009074,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0019439,GO:0019538,GO:0019752,GO:0032787,GO:0033345,GO:0034641,GO:0042737,GO:0043170,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0070011,GO:0071704,GO:0072329,GO:0140096,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902221,GO:1902222 3.4.19.5 ko:K13051 - - - - ko00000,ko01000,ko01002 - - - Asparaginase_2 k59_1006826_1 402777.KB235904_gene3812 2.75e-13 71.2 COG4122@1|root,COG4122@2|Bacteria,1G5B0@1117|Cyanobacteria,1HB99@1150|Oscillatoriales 1117|Cyanobacteria S Methyltransferase domain - - - - - - - - - - - - Methyltransf_24,TPR_2 k59_1006826_2 1238190.AMQY01000021_gene1593 3.99e-17 84.0 COG0749@1|root,COG0749@2|Bacteria,1MWX7@1224|Proteobacteria,1S0Q1@1236|Gammaproteobacteria 1236|Gammaproteobacteria L ORF located using Glimmer RBSfinder - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A,DNA_pol_A_exo1 k59_696667_1 179408.Osc7112_2555 1.03e-70 218.0 COG1335@1|root,COG1335@2|Bacteria,1G3QK@1117|Cyanobacteria,1HEG7@1150|Oscillatoriales 1117|Cyanobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_329812_1 194439.CT1215 7.52e-16 80.9 COG3118@1|root,COG3118@2|Bacteria,1FDP7@1090|Chlorobi 1090|Chlorobi O PFAM Thioredoxin domain - - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_20,Thioredoxin k59_1060890_1 1237149.C900_05256 6.51e-64 219.0 COG1131@1|root,COG1131@2|Bacteria,4NHPD@976|Bacteroidetes,47KQD@768503|Cytophagia 976|Bacteroidetes V ABC-2 type transporter - - - - - - - - - - - - ABC2_membrane,ABC_tran,TerB k59_1373794_1 861299.J421_2243 1.13e-237 674.0 COG1523@1|root,COG1523@2|Bacteria,1ZV42@142182|Gemmatimonadetes 2|Bacteria G Carbohydrate-binding module 48 (Isoamylase N-terminal domain) glgX - 3.2.1.196,3.2.1.68 ko:K01214,ko:K02438 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_1274003_1 172088.AUGA01000002_gene5872 1.04e-115 340.0 COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,3JTJY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C FMN-dependent dehydrogenase lldD1 GO:0002218,GO:0002253,GO:0002376,GO:0002682,GO:0002684,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006950,GO:0006952,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009605,GO:0009607,GO:0009617,GO:0009987,GO:0010204,GO:0016999,GO:0017000,GO:0017144,GO:0023052,GO:0031347,GO:0031349,GO:0042579,GO:0042742,GO:0042743,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0045088,GO:0045089,GO:0048518,GO:0048583,GO:0048584,GO:0050665,GO:0050776,GO:0050778,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0072593,GO:0080134,GO:0098542,GO:1903409 1.1.2.3 ko:K00101 ko00620,ko01100,map00620,map01100 - R00196 RC00044 ko00000,ko00001,ko01000 - - - FMN_dh k59_224728_1 1193181.BN10_930005 9.71e-08 55.1 COG3714@1|root,COG3714@2|Bacteria,2IG79@201174|Actinobacteria,4FGG0@85021|Intrasporangiaceae 201174|Actinobacteria S YhhN family - - - - - - - - - - - - YhhN k59_224728_2 756272.Plabr_2883 5.56e-36 130.0 COG0515@1|root,COG0515@2|Bacteria,2J2D5@203682|Planctomycetes 203682|Planctomycetes KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1274014_1 743299.Acife_1355 1.31e-101 315.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,2NBVX@225057|Acidithiobacillales 225057|Acidithiobacillales L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_746797_1 1121459.AQXE01000019_gene1880 2.31e-28 117.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,42S30@68525|delta/epsilon subdivisions,2WQ5S@28221|Deltaproteobacteria,2MAPP@213115|Desulfovibrionales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - Transposase_mut k59_1428314_1 436308.Nmar_0321 4.4e-91 270.0 arCOG00517@1|root,arCOG00517@2157|Archaea,41SHJ@651137|Thaumarchaeota 651137|Thaumarchaeota S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1219825_1 1089551.KE386572_gene1862 5.06e-53 182.0 COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,2TQWV@28211|Alphaproteobacteria,4BTDH@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Mitochondrial fission ELM1 - - - ko:K07276 - - - - ko00000 - - - Mito_fiss_Elm1 k59_1428321_1 1353531.AZNX01000010_gene1069 1.87e-90 286.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1112943_1 861299.J421_3811 1.97e-29 120.0 COG1640@1|root,COG1640@2|Bacteria,1ZU23@142182|Gemmatimonadetes 142182|Gemmatimonadetes G 4-alpha-glucanotransferase - - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_1219826_1 856793.MICA_1862 1.38e-54 188.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2TSM0@28211|Alphaproteobacteria,4BPSI@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_1219826_2 272134.KB731326_gene358 0.000596 41.6 COG0768@1|root,COG0768@2|Bacteria,1G03W@1117|Cyanobacteria,1H7NT@1150|Oscillatoriales 1117|Cyanobacteria M Penicillin-binding protein, dimerisation domain mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_1373823_3 1408823.AXUS01000003_gene427 4.49e-13 64.7 COG1553@1|root,COG1553@2|Bacteria,1VA7W@1239|Firmicutes,24P8W@186801|Clostridia 186801|Clostridia P Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE - - - - - - - - - - - - DrsE k59_543035_1 1448389.BAVQ01000043_gene1804 4.52e-24 99.8 COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria 201174|Actinobacteria I hydrolase ytpA GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010941,GO:0010942,GO:0016020,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0030312,GO:0031341,GO:0031343,GO:0031640,GO:0035821,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044364,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0044533,GO:0046486,GO:0046503,GO:0047372,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051701,GO:0051704,GO:0051709,GO:0051712,GO:0051817,GO:0051818,GO:0051883,GO:0052040,GO:0052042,GO:0052150,GO:0052151,GO:0052248,GO:0052330,GO:0052433,GO:0052501,GO:0052689,GO:0065007,GO:0071704,GO:0071944,GO:1901575 3.1.1.5 ko:K01048 ko00564,map00564 - - - ko00000,ko00001,ko01000 - - - Hydrolase_4 k59_752334_1 546270.GEMHA0001_0635 9.54e-08 54.7 COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,4HAZK@91061|Bacilli,3WEA7@539002|Bacillales incertae sedis 91061|Bacilli O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_752334_2 886293.Sinac_1453 3.11e-44 156.0 COG0438@1|root,COG0438@2|Bacteria,2IXRB@203682|Planctomycetes 203682|Planctomycetes M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_335264_1 1232410.KI421421_gene3825 3.72e-76 256.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43U53@69541|Desulfuromonadales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_811793_1 1207055.C100_12550 3.34e-47 166.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_1642451_1 648757.Rvan_3171 2.54e-109 324.0 COG3415@1|root,COG3415@2|Bacteria,1QWK4@1224|Proteobacteria,2TX0C@28211|Alphaproteobacteria 28211|Alphaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - DDE_3,HTH_23,HTH_29,HTH_32 k59_960674_1 404589.Anae109_0515 5.74e-86 264.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,42M3M@68525|delta/epsilon subdivisions,2WJ8B@28221|Deltaproteobacteria,2YTZM@29|Myxococcales 28221|Deltaproteobacteria O hydrogenase expression formation protein HypE hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_1167612_1 330214.NIDE4322 1.86e-61 201.0 COG0744@1|root,COG0744@2|Bacteria,3J127@40117|Nitrospirae 40117|Nitrospirae M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_1642463_2 1502770.JQMG01000001_gene201 5.79e-43 147.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2VHAQ@28216|Betaproteobacteria,2KMB3@206350|Nitrosomonadales 206350|Nitrosomonadales V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_1323996_1 1121035.AUCH01000015_gene2588 2.26e-10 61.2 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2VJ29@28216|Betaproteobacteria,2KUJY@206389|Rhodocyclales 206389|Rhodocyclales G Phosphoglucomutase - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_440071_1 768671.ThimaDRAFT_2417 1.45e-108 325.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RS8H@1236|Gammaproteobacteria,1WWVZ@135613|Chromatiales 135613|Chromatiales C Belongs to the citrate synthase family - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_80036_1 1205680.CAKO01000029_gene5115 5.99e-85 263.0 COG2141@1|root,COG2141@2|Bacteria,1R7GC@1224|Proteobacteria,2U0DW@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_752356_2 926549.KI421517_gene1092 1.58e-14 77.8 COG3420@1|root,COG3420@2|Bacteria,4P1XP@976|Bacteroidetes,47UIA@768503|Cytophagia 976|Bacteroidetes P Parallel beta-helix repeats - - - - - - - - - - - - - k59_543068_1 2055.JNXA01000005_gene435 3.61e-79 245.0 COG2141@1|root,COG2141@2|Bacteria,2GPA5@201174|Actinobacteria,4GA51@85026|Gordoniaceae 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_909690_1 269799.Gmet_2358 2.94e-54 178.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,42QNS@68525|delta/epsilon subdivisions,2WMSN@28221|Deltaproteobacteria,43SYM@69541|Desulfuromonadales 28221|Deltaproteobacteria V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_909690_2 187272.Mlg_1440 1.06e-24 103.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1WW0V@135613|Chromatiales 135613|Chromatiales M lipoprotein releasing system, transmembrane protein, LolC E family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_1489366_1 316067.Geob_3163 2.2e-62 198.0 COG4380@1|root,COG4380@2|Bacteria,1NJYS@1224|Proteobacteria,42X1E@68525|delta/epsilon subdivisions,2WTEE@28221|Deltaproteobacteria,43VPV@69541|Desulfuromonadales 28221|Deltaproteobacteria S Putative bacterial lipoprotein (DUF799) - - - - - - - - - - - - DUF799 k59_1281769_1 96561.Dole_2610 6.34e-13 72.4 COG3386@1|root,COG3386@2|Bacteria,1QUU9@1224|Proteobacteria,42ZTS@68525|delta/epsilon subdivisions,2WVGZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria G PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - - k59_752362_1 1229909.NSED_09760 3.93e-146 416.0 COG0483@1|root,arCOG01349@2157|Archaea,41T8P@651137|Thaumarchaeota 651137|Thaumarchaeota G Inositol monophosphatase - - 3.1.3.25,3.1.3.7 ko:K01082,ko:K01092 ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070 M00131 R00188,R00508,R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000,ko03016 - - - Inositol_P k59_752362_2 1229909.NSED_09755 3.41e-67 206.0 COG0529@1|root,arCOG01040@2157|Archaea 2157|Archaea F Catalyzes the synthesis of activated sulfate cysC - 2.7.1.25 ko:K00860,ko:K07028 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - AAA_33,APS_kinase k59_960690_1 38833.XP_003058474.1 1.34e-16 82.8 2DZ7R@1|root,2S6WK@2759|Eukaryota 2759|Eukaryota S Methyltransferase domain - - - - - - - - - - - - Glyco_transf_8,Methyltransf_24 k59_960690_4 1038860.AXAP01000004_gene5231 0.00026 47.4 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria,3JSPI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_1588136_2 243233.MCA0816 1.63e-58 184.0 COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,1S2N9@1236|Gammaproteobacteria,1XEUU@135618|Methylococcales 135618|Methylococcales F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k59_654734_1 396588.Tgr7_0300 2.22e-97 303.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1WWYZ@135613|Chromatiales 135613|Chromatiales E PFAM Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_389554_1 1172185.KB911518_gene2736 3.41e-18 83.2 COG3631@1|root,COG3631@2|Bacteria 2|Bacteria S light absorption - - - - - - - - - - - - Abi_2,HTH_18,SnoaL_2,SnoaL_4 k59_230099_1 1203605.HMPREF1531_00221 2.15e-11 69.7 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,4DPBE@85009|Propionibacteriales 201174|Actinobacteria C ferredoxin oxidoreductase korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1119357_1 335543.Sfum_3063 2.59e-47 166.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WJKC@28221|Deltaproteobacteria,2MQ40@213462|Syntrophobacterales 28221|Deltaproteobacteria M PDZ domain (Also known as DHR or GLGF) ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_910705_1 1382306.JNIM01000001_gene1030 1.97e-131 385.0 COG2873@1|root,COG2873@2|Bacteria,2G5NS@200795|Chloroflexi 200795|Chloroflexi E PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein - - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - CoA_binding_2,Cys_Met_Meta_PP k59_175442_1 187272.Mlg_0463 9.76e-20 82.0 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria,1WYH7@135613|Chromatiales 135613|Chromatiales J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_175442_2 395493.BegalDRAFT_2618 2.84e-121 350.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,45ZXA@72273|Thiotrichales 72273|Thiotrichales J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_175442_3 765913.ThidrDRAFT_1744 2.14e-68 209.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,1S201@1236|Gammaproteobacteria,1WY6U@135613|Chromatiales 135613|Chromatiales J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_175442_4 582744.Msip34_0309 9.11e-11 58.5 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2VVNT@28216|Betaproteobacteria,2KNAA@206350|Nitrosomonadales 206350|Nitrosomonadales J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_175442_5 265072.Mfla_0288 1.12e-33 118.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2VU2G@28216|Betaproteobacteria,2KN30@206350|Nitrosomonadales 206350|Nitrosomonadales J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_1324761_1 436308.Nmar_1061 9.76e-34 123.0 arCOG01995@1|root,arCOG01995@2157|Archaea,41T3M@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - SpoIIM k59_1324761_2 436308.Nmar_0002 1.81e-91 281.0 COG1311@1|root,arCOG04455@2157|Archaea,41T0D@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polB - 2.7.7.7 ko:K02323 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - DNA_pol_E_B k59_128550_2 436308.Nmar_1624 1.37e-33 118.0 COG2238@1|root,arCOG01344@2157|Archaea,41SK1@651137|Thaumarchaeota 651137|Thaumarchaeota J May be involved in maturation of the 30S ribosomal subunit rps19e - - ko:K02966 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19e k59_1067467_1 330214.NIDE4060 5.52e-38 136.0 COG1858@1|root,COG1858@2|Bacteria,3J0GH@40117|Nitrospirae 40117|Nitrospirae C Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_1227576_1 445696.E3SSZ7_9CAUD 2.91e-19 82.0 4QAY0@10239|Viruses,4QVSS@35237|dsDNA viruses no RNA stage,4QQ2W@28883|Caudovirales,4QJ6J@10662|Myoviridae 10662|Myoviridae S Hsp20/alpha crystallin family - - - - - - - - - - - - - k59_1227576_4 444860.E3SJ44_9CAUD 1.61e-178 520.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QHVQ@10662|Myoviridae 10662|Myoviridae S nucleotide binding - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016032,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019058,GO:0019079,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0039686,GO:0039693,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044403,GO:0044419,GO:0046483,GO:0051704,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_858336_1 864702.OsccyDRAFT_4664 1.83e-10 61.6 COG0589@1|root,COG0589@2|Bacteria,1G895@1117|Cyanobacteria,1HCCY@1150|Oscillatoriales 1117|Cyanobacteria T Universal stress protein - - - - - - - - - - - - Usp k59_1589157_1 317655.Sala_1008 1.36e-151 439.0 COG3670@1|root,COG3670@2|Bacteria,1MY1X@1224|Proteobacteria,2TS7A@28211|Alphaproteobacteria,2K2TY@204457|Sphingomonadales 204457|Sphingomonadales Q Retinal pigment epithelial membrane protein - - 1.13.11.82 ko:K11159,ko:K21822 - - - - ko00000,ko01000 - - - RPE65 k59_390343_1 1168065.DOK_18630 4.18e-51 181.0 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,1J8FD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C PQQ-like domain - - 1.1.2.8,1.1.9.1 ko:K00114,ko:K17760 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_1589161_1 1123376.AUIU01000013_gene1827 5.81e-47 160.0 COG1242@1|root,COG1242@2|Bacteria 2|Bacteria K 4 iron, 4 sulfur cluster binding yhcC GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540 - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C k59_1589161_2 330214.NIDE2460 1.49e-29 112.0 COG0177@1|root,COG0177@2|Bacteria,3J0K6@40117|Nitrospirae 40117|Nitrospirae L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD k59_813172_1 1198232.CYCME_2423 1.82e-35 123.0 COG2924@1|root,COG2924@2|Bacteria,1QSXN@1224|Proteobacteria,1SS8K@1236|Gammaproteobacteria 1236|Gammaproteobacteria CO Bacterial Fe(2+) trafficking - - - - - - - - - - - - Iron_traffic k59_1283111_1 227377.CBU_0232 3.13e-90 297.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1JD5C@118969|Legionellales 118969|Legionellales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_390347_1 1121937.AUHJ01000010_gene1707 1.92e-136 401.0 COG2159@1|root,COG2159@2|Bacteria,1PZ2I@1224|Proteobacteria,1S1Y9@1236|Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase of the TIM-barrel fold - - - - - - - - - - - - Amidohydro_2 k59_390347_2 68570.DC74_2330 1.01e-19 91.3 COG2159@1|root,COG2159@2|Bacteria,2HG7W@201174|Actinobacteria 201174|Actinobacteria S amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_858351_1 279238.Saro_3712 1.64e-164 468.0 2DMXI@1|root,32U9G@2|Bacteria,1R4N1@1224|Proteobacteria,2U3EE@28211|Alphaproteobacteria,2K2NC@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1589173_1 59196.RICGR_0629 5.01e-11 67.0 COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,1RQ6M@1236|Gammaproteobacteria,1JGRE@118969|Legionellales 118969|Legionellales M Cytidylyltransferase family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_753392_1 330214.NIDE3967 6.67e-83 260.0 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity - - - - - - - - - - - - OEP k59_497284_1 1279017.AQYJ01000026_gene57 3.35e-20 95.5 COG1360@1|root,COG2885@1|root,COG1360@2|Bacteria,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,1T4AK@1236|Gammaproteobacteria,46ACU@72275|Alteromonadaceae 1236|Gammaproteobacteria M OmpA family - - - - - - - - - - - - DUF11,OmpA k59_703294_1 1242864.D187_009721 1.38e-67 221.0 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,4396E@68525|delta/epsilon subdivisions,2X4D5@28221|Deltaproteobacteria,2YYSG@29|Myxococcales 28221|Deltaproteobacteria C Cytochrome P450 - - - - - - - - - - - - p450 k59_128608_2 228405.HNE_2815 2.1e-05 50.4 COG0625@1|root,COG0625@2|Bacteria,1Q05U@1224|Proteobacteria,2U4HZ@28211|Alphaproteobacteria,43XPW@69657|Hyphomonadaceae 28211|Alphaproteobacteria O COG0625 Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_C_3,GST_N,GST_N_2,GST_N_3 k59_813205_1 1229909.NSED_09870 1.11e-85 260.0 COG0175@1|root,arCOG00124@2157|Archaea,41S9Q@651137|Thaumarchaeota 651137|Thaumarchaeota E Phosphoadenosine phosphosulfate reductase family - - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_497298_1 1265505.ATUG01000002_gene1874 1.59e-65 213.0 COG4191@1|root,COG4191@2|Bacteria,1R6WR@1224|Proteobacteria,42PFK@68525|delta/epsilon subdivisions,2WJSP@28221|Deltaproteobacteria,2MHRP@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_813208_1 765912.Thimo_1188 2.64e-87 273.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales 135613|Chromatiales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_813209_1 1485544.JQKP01000010_gene802 4.9e-30 108.0 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,2VSI3@28216|Betaproteobacteria,44VUW@713636|Nitrosomonadales 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_596903_1 436308.Nmar_1109 1.42e-223 619.0 COG2141@1|root,arCOG02410@2157|Archaea,41SBM@651137|Thaumarchaeota 651137|Thaumarchaeota C Luciferase-like monooxygenase - - - ko:K14728 - - - - ko00000,ko01000 - - - Bac_luciferase k59_336357_1 909663.KI867150_gene2220 2.9e-73 233.0 COG2211@1|root,COG2211@2|Bacteria,1QTSE@1224|Proteobacteria,43C8U@68525|delta/epsilon subdivisions,2X7J6@28221|Deltaproteobacteria,2MSKV@213462|Syntrophobacterales 28221|Deltaproteobacteria G Acetyl-coenzyme A transporter 1 - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_1227669_1 1500257.JQNM01000011_gene5597 2.1e-11 65.5 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2TSX2@28211|Alphaproteobacteria,4BA0J@82115|Rhizobiaceae 28211|Alphaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_1227669_2 1408224.SAMCCGM7_c2733 4.98e-12 68.6 COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,2U874@28211|Alphaproteobacteria,4B9DE@82115|Rhizobiaceae 28211|Alphaproteobacteria O PPIC-type PPIASE domain - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2 k59_1530280_1 2340.JV46_06920 5.96e-28 113.0 COG0381@1|root,COG0381@2|Bacteria,1MWZN@1224|Proteobacteria,1T9RJ@1236|Gammaproteobacteria,1J6NC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M UDP-N-acetylglucosamine 2-epimerase - - - - - - - - - - - - Epimerase_2 k59_283998_1 330214.NIDE0950 9.08e-37 128.0 COG0537@1|root,COG0537@2|Bacteria 2|Bacteria FG bis(5'-adenosyl)-triphosphatase activity - - - - - - - - - - - - HIT k59_596921_1 713587.THITH_03440 5.84e-34 117.0 COG2442@1|root,COG2442@2|Bacteria,1N7GJ@1224|Proteobacteria,1SCUP@1236|Gammaproteobacteria,1WZKZ@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF433) - - - - - - - - - - - - DUF433 k59_1019432_1 706191.PANA_0714 1e-52 182.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,3VZ3W@53335|Pantoea 1236|Gammaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - iECO103_1326.ECO103_0087,iECO111_1330.ECO111_0088,iECW_1372.ECW_m0084,iEKO11_1354.EKO11_3829,iWFL_1372.ECW_m0084,ic_1306.c0103 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1019432_2 522306.CAP2UW1_0575 3.18e-50 174.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2VH2H@28216|Betaproteobacteria,1KQ72@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10,6.3.2.13 ko:K01929,ko:K15792 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R02788,R04573,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_819974_1 1173026.Glo7428_0430 9.28e-47 171.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria 1117|Cyanobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GAF,GGDEF,PAS_3,PAS_9 k59_179652_1 1382356.JQMP01000003_gene1419 1.41e-96 296.0 COG0407@1|root,COG0407@2|Bacteria,2G5NU@200795|Chloroflexi,27XWH@189775|Thermomicrobia 189775|Thermomicrobia H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_1650674_1 396588.Tgr7_0213 4.85e-105 307.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,1WVVY@135613|Chromatiales 135613|Chromatiales E imidazoleglycerol-phosphate dehydratase hisB - 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD k59_916127_1 445696.E3SST8_9CAUD 7.85e-45 171.0 4QEE7@10239|Viruses,4QV59@35237|dsDNA viruses no RNA stage,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae 10662|Myoviridae S Pfam:DUF4815 - - - - - - - - - - - - - k59_1289914_1 1380390.JIAT01000009_gene1077 7.9e-45 149.0 COG0599@1|root,COG0599@2|Bacteria,2IM8G@201174|Actinobacteria 201174|Actinobacteria S PFAM Carboxymuconolactone decarboxylase pcaC - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD k59_548962_1 1120983.KB894572_gene2862 2.94e-60 199.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,1JN20@119043|Rhodobiaceae 28211|Alphaproteobacteria E Aminotransferase class-III bioA - 2.6.1.18 ko:K00822 ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100 - R00907,R04187 RC00008,RC00062,RC00160 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_447313_1 2340.JV46_28260 2.04e-91 280.0 COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,1RN6V@1236|Gammaproteobacteria,1J8PX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Binding-protein-dependent transport system inner membrane component aapQ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K09970 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_1443034_1 448385.sce8739 9.32e-24 107.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,4380T@68525|delta/epsilon subdivisions,2X3AT@28221|Deltaproteobacteria,2YZH7@29|Myxococcales 28221|Deltaproteobacteria K Forkhead associated domain - - - - - - - - - - - - FHA,HTH_8,Sigma54_activat,Yop-YscD_cpl k59_503986_2 298655.KI912267_gene7578 2.34e-10 64.3 COG1262@1|root,COG1262@2|Bacteria,2H1UD@201174|Actinobacteria 201174|Actinobacteria S Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase k59_708091_1 1437824.BN940_17626 2.16e-94 291.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2VHF7@28216|Betaproteobacteria,3T2GD@506|Alcaligenaceae 28216|Betaproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,S4_2,tRNA-synt_1b k59_1172779_1 158500.BV97_04770 1.32e-52 176.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,2K3Y3@204457|Sphingomonadales 204457|Sphingomonadales L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_1172779_2 1122214.AQWH01000016_gene1599 3.57e-26 107.0 COG1484@1|root,COG4584@1|root,COG1484@2|Bacteria,COG4584@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA replication protein - - - - - - - - - - - - IstB_IS21 k59_863292_1 112098.XP_008619107.1 1.03e-62 214.0 COG4108@1|root,KOG0464@2759|Eukaryota 2759|Eukaryota J Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation GFM2 GO:0003674,GO:0003824,GO:0003924,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0022411,GO:0031974,GO:0032543,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0070126,GO:0071704,GO:0071826,GO:0071840,GO:0140053,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_341664_2 420324.KI911970_gene1564 9.96e-164 479.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_13573_2 1280692.AUJL01000001_gene234 3.75e-06 48.9 COG0624@1|root,COG0624@2|Bacteria,1TQ0P@1239|Firmicutes,24BF2@186801|Clostridia,36GQM@31979|Clostridiaceae 186801|Clostridia E TIGRFAM amidase, hydantoinase carbamoylase family amaB - 3.5.3.9 ko:K02083 ko00230,ko01120,map00230,map01120 - R02423 RC00064 ko00000,ko00001,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1020407_1 1395516.PMO01_12630 1.15e-21 100.0 COG0421@1|root,COG0421@2|Bacteria,1QVJA@1224|Proteobacteria,1RYYT@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Spermidine synthase - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_1594906_1 1202962.KB907154_gene809 3.86e-83 266.0 COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,1S06C@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Alkaline phosphatase pafA - - - - - - - - - - - Phosphodiest k59_1498810_1 756276.I3ULX0_9VIRU 7.02e-36 139.0 4QASG@10239|Viruses,4QZZU@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_864250_1 1267533.KB906738_gene2142 1.84e-07 58.2 COG3920@1|root,COG4191@1|root,COG3920@2|Bacteria,COG4191@2|Bacteria,3Y7B2@57723|Acidobacteria,2JKKQ@204432|Acidobacteriia 204432|Acidobacteriia T PAS fold - - - - - - - - - - - - HATPase_c,PAS k59_448675_1 335543.Sfum_2414 6.12e-82 256.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MG3@68525|delta/epsilon subdivisions,2WKC7@28221|Deltaproteobacteria,2MQ7Q@213462|Syntrophobacterales 28221|Deltaproteobacteria Q COGs COG0767 ABC-type transport system involved in resistance to organic solvents permease component - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_1173701_1 1280941.HY2_15430 1.41e-28 119.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2UPPD@28211|Alphaproteobacteria,43ZBQ@69657|Hyphomonadaceae 28211|Alphaproteobacteria I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_89264_1 644968.DFW101_1120 9.59e-58 183.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,42RIR@68525|delta/epsilon subdivisions,2WP3R@28221|Deltaproteobacteria,2MBKB@213115|Desulfovibrionales 28221|Deltaproteobacteria F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_917637_1 351348.Maqu_0874 5.76e-117 351.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,4642R@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains pilR - - ko:K02481,ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_1074238_1 1123261.AXDW01000002_gene1501 2.29e-41 150.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1S1T4@1236|Gammaproteobacteria,1XCD5@135614|Xanthomonadales 135614|Xanthomonadales KLT Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - Pkinase,cNMP_binding k59_448686_1 1380391.JIAS01000011_gene4999 2.68e-22 100.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2TQXJ@28211|Alphaproteobacteria,2JPKM@204441|Rhodospirillales 204441|Rhodospirillales M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_1594927_1 1348657.M622_02695 4.96e-67 215.0 COG1960@1|root,COG1960@2|Bacteria,1R6EH@1224|Proteobacteria,2VNZC@28216|Betaproteobacteria 28216|Betaproteobacteria C Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1385438_1 102129.Lepto7375DRAFT_1532 1.85e-46 159.0 COG1796@1|root,COG1796@2|Bacteria,1GC4M@1117|Cyanobacteria 1117|Cyanobacteria L Helix-hairpin-helix domain - - - - - - - - - - - - HHH_8 k59_759209_1 395494.Galf_2736 2.81e-12 71.2 COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2VJ8M@28216|Betaproteobacteria,44VV2@713636|Nitrosomonadales 28216|Betaproteobacteria S Serine aminopeptidase, S33 - - - ko:K07018 - - - - ko00000 - - - Hydrolase_4,Peptidase_S15 k59_759209_2 1280947.HY30_08810 5.76e-10 61.6 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2TQTB@28211|Alphaproteobacteria,43WVU@69657|Hyphomonadaceae 28211|Alphaproteobacteria T COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation ntrY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_1535460_1 1077285.AGDG01000029_gene1344 2.49e-41 153.0 COG1215@1|root,COG1215@2|Bacteria,4NEG0@976|Bacteroidetes,2FM0D@200643|Bacteroidia,4AMHX@815|Bacteroidaceae 976|Bacteroidetes M Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 k59_1235056_1 945713.IALB_0798 7.18e-58 195.0 COG0492@1|root,COG0492@2|Bacteria 2|Bacteria C ferredoxin-NADP+ reductase activity - - - - - - - - - - - - FAD_binding_2,FAD_oxidored,Pyr_redox_2,Thioredoxin_3,cNMP_binding k59_821396_2 326427.Cagg_2509 1.43e-24 104.0 COG1058@1|root,COG1058@2|Bacteria,2G6DU@200795|Chloroflexi,374WE@32061|Chloroflexia 32061|Chloroflexia S PFAM molybdopterin binding domain - - - - - - - - - - - - MoCF_biosynth k59_89293_1 109871.XP_006676297.1 3.26e-11 67.4 COG0564@1|root,KOG1919@2759|Eukaryota,38TF5@33154|Opisthokonta,3P4HP@4751|Fungi 4751|Fungi A RNA pseudouridylate synthase - - - - - - - - - - - - PseudoU_synth_2 k59_917665_1 2340.JV46_17540 1.36e-54 184.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1J70K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Dimerisation domain of Zinc Transporter fieF - - - - - - - - - - - Cation_efflux,ZT_dimer k59_1498852_1 1150600.ADIARSV_2024 5.23e-33 136.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,4PM8I@976|Bacteroidetes,1IQP3@117747|Sphingobacteriia 976|Bacteroidetes QU Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,PD40 k59_342999_1 1437824.BN940_10871 1.88e-27 115.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2W02U@28216|Betaproteobacteria,3T8BI@506|Alcaligenaceae 28216|Betaproteobacteria M Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_505407_1 1229909.NSED_08340 6.59e-87 271.0 COG0031@1|root,COG0607@1|root,arCOG01430@2157|Archaea,arCOG02021@2157|Archaea,41SYY@651137|Thaumarchaeota 651137|Thaumarchaeota E Pyridoxal-phosphate dependent enzyme - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_343010_2 1026882.MAMP_02239 1.92e-18 82.0 COG2138@1|root,COG2138@2|Bacteria,1N00J@1224|Proteobacteria,1SEQ6@1236|Gammaproteobacteria,462KV@72273|Thiotrichales 72273|Thiotrichales S CbiX - - 4.99.1.4 ko:K03794 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R02864 RC01012 ko00000,ko00001,ko00002,ko01000 - - - CbiX k59_1235087_1 1304885.AUEY01000008_gene2059 8.63e-12 66.6 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2WKX1@28221|Deltaproteobacteria,2MHZU@213118|Desulfobacterales 28221|Deltaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_664365_1 1408445.JHXP01000024_gene603 5.34e-82 251.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1JCXN@118969|Legionellales 118969|Legionellales L Endonuclease/Exonuclease/phosphatase family xthA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_550027_2 97139.C824_05071 7.51e-77 243.0 COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,36DTS@31979|Clostridiaceae 186801|Clostridia K Belongs to the ParB family spo0J - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_550027_3 1196029.ALIM01000037_gene1087 6.53e-10 56.6 COG1828@1|root,COG1828@2|Bacteria,1VEH1@1239|Firmicutes,4HP0E@91061|Bacilli,1ZHUG@1386|Bacillus 91061|Bacilli F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purS - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU06460 PurS k59_1020459_1 663610.JQKO01000005_gene2385 4.82e-25 104.0 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2U450@28211|Alphaproteobacteria,3NAA2@45404|Beijerinckiaceae 28211|Alphaproteobacteria T Sigma factor PP2C-like phosphatases - - 3.1.3.16 ko:K01090,ko:K11915,ko:K20074 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01009,ko02044 - - - PP2C,PP2C_2 k59_1020459_2 234267.Acid_6465 1.17e-10 61.6 COG1629@1|root,COG4771@2|Bacteria,3Y33S@57723|Acidobacteria 57723|Acidobacteria P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg,Plug k59_237084_1 754477.Q7C_108 2.32e-43 149.0 COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,1RSGA@1236|Gammaproteobacteria,460EZ@72273|Thiotrichales 72273|Thiotrichales S Uncharacterised protein family (UPF0014) - - - ko:K02069 - M00211 - - ko00000,ko00002,ko02000 9.B.25.1 - - UPF0014 k59_602722_2 1041139.KB902682_gene2282 1.32e-15 80.5 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,4B81Q@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate - - - - - - - - - - - - AAA_16,BTAD,DZR,Guanylate_cyc,SAM_1 k59_1074298_1 1123247.AUIJ01000002_gene2249 3.94e-50 172.0 COG0500@1|root,COG2226@2|Bacteria,1MW7J@1224|Proteobacteria,2TSZC@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q O-methyltransferase, family 2 - - - - - - - - - - - - Dimerisation2,Methyltransf_2 k59_1535491_1 1380387.JADM01000006_gene1233 4.9e-16 79.7 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1XQZT@135619|Oceanospirillales 135619|Oceanospirillales PT COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - Rhodanese,cNMP_binding k59_1444012_1 395493.BegalDRAFT_0361 2.29e-68 216.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,4606H@72273|Thiotrichales 72273|Thiotrichales P CBS domain - - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_343047_1 1157640.AQWO01000004_gene4950 2.16e-28 114.0 COG3670@1|root,COG3670@2|Bacteria,2GK7D@201174|Actinobacteria 201174|Actinobacteria Q dioxygenase - - - ko:K11159 - - - - ko00000 - - - RPE65 k59_1126432_1 1254432.SCE1572_34585 5.17e-47 161.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) tnp3510a - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_89370_2 1122604.JONR01000060_gene2302 8.67e-08 56.2 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1X2Z8@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC k59_135932_1 413404.Rmag_0290 2.55e-49 171.0 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria,1J54W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family gor GO:0000166,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071949,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - iZ_1308.Z4900 Pyr_redox_2,Pyr_redox_dim k59_1126436_1 1123393.KB891326_gene66 8.52e-169 487.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,2VJP0@28216|Betaproteobacteria,1KS9Q@119069|Hydrogenophilales 119069|Hydrogenophilales HJ RimK-like ATPgrasp N-terminal domain - - - - - - - - - - - - RLAN k59_1126436_2 1095769.CAHF01000008_gene3640 9.44e-63 200.0 COG3271@1|root,COG3271@2|Bacteria,1RAD5@1224|Proteobacteria,2VIY6@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_290870_1 1522072.IL54_4377 9.14e-05 45.8 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2TRZA@28211|Alphaproteobacteria,2K0H7@204457|Sphingomonadales 204457|Sphingomonadales M sugar transferase - - - - - - - - - - - - Bac_transf,CoA_binding_3 k59_290870_2 296591.Bpro_1407 5.75e-05 44.3 COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2VNG1@28216|Betaproteobacteria,4AJD1@80864|Comamonadaceae 28216|Betaproteobacteria C Berberine and berberine like - - - - - - - - - - - - BBE,FAD_binding_4 k59_709200_1 1382303.JPOM01000001_gene960 2.14e-72 236.0 COG0642@1|root,COG0642@2|Bacteria,1QTVA@1224|Proteobacteria,2U5EI@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase MA20_15235 - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1535512_1 795797.C497_10933 8.99e-20 95.5 COG3119@1|root,arCOG02785@2157|Archaea,2Y8G5@28890|Euryarchaeota,241AK@183963|Halobacteria 183963|Halobacteria P COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - Sulfatase k59_1330115_1 314225.ELI_01225 6.45e-30 117.0 2C5U9@1|root,2Z9NJ@2|Bacteria,1NEK8@1224|Proteobacteria,2U4EQ@28211|Alphaproteobacteria,2K10J@204457|Sphingomonadales 204457|Sphingomonadales S Bacterial protein of unknown function (Gcw_chp) - - - - - - - - - - - - Gcw_chp k59_237127_1 1380394.JADL01000001_gene2946 3.07e-68 220.0 COG2230@1|root,COG2230@2|Bacteria,1N038@1224|Proteobacteria,2UDD9@28211|Alphaproteobacteria 28211|Alphaproteobacteria M SAM dependent carboxyl methyltransferase - - - - - - - - - - - - Methyltransf_7 k59_135954_1 469371.Tbis_2709 2.39e-125 367.0 COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,4E0VQ@85010|Pseudonocardiales 201174|Actinobacteria S alcohol dehydrogenase adhA - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1126461_1 1085623.GNIT_2958 2.74e-37 140.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria,465XQ@72275|Alteromonadaceae 1236|Gammaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1126461_2 1122134.KB893650_gene1464 2.16e-51 169.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RR3R@1236|Gammaproteobacteria,1XR7H@135619|Oceanospirillales 135619|Oceanospirillales V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1595009_1 1589733.A0A0C5AEC6_9CAUD 4.39e-19 87.4 4QHGY@10239|Viruses,4QRJK@28883|Caudovirales,4QI22@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1126474_2 298654.FraEuI1c_1330 7.58e-11 65.1 COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria 201174|Actinobacteria O Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_456602_1 697282.Mettu_1687 1.88e-87 265.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1XDSQ@135618|Methylococcales 135618|Methylococcales F SAICAR synthetase purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_1082478_1 1123253.AUBD01000005_gene44 1.75e-49 169.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1X4AP@135614|Xanthomonadales 135614|Xanthomonadales J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 k59_143480_1 272631.ML2564 3.16e-09 63.5 COG0183@1|root,COG0183@2|Bacteria,2GJI8@201174|Actinobacteria,234WP@1762|Mycobacteriaceae 201174|Actinobacteria I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation fadA2 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_870626_2 330214.NIDE4023 8.29e-82 245.0 COG1959@1|root,COG1959@2|Bacteria,3J18M@40117|Nitrospirae 40117|Nitrospirae K Transcriptional regulator - - - - - - - - - - - - Rrf2 k59_716041_1 330214.NIDE0488 8.9e-103 309.0 COG0019@1|root,COG0019@2|Bacteria,3J0CR@40117|Nitrospirae 40117|Nitrospirae E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_298877_1 420324.KI912002_gene8466 8.03e-24 99.4 COG2114@1|root,COG2114@2|Bacteria 2|Bacteria T Pfam Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - Guanylate_cyc,TPR_16,TPR_19,TPR_2,TPR_8,TolB_N k59_351010_1 330214.NIDE0779 1.86e-96 293.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_1600926_2 1005048.CFU_3309 5.76e-84 267.0 COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,2VHAK@28216|Betaproteobacteria,474F5@75682|Oxalobacteraceae 28216|Betaproteobacteria O Carbamoyltransferase N-terminus - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_830906_1 395495.Lcho_0017 1.67e-19 94.7 COG0457@1|root,COG0457@2|Bacteria,1MWAQ@1224|Proteobacteria,2VK8K@28216|Betaproteobacteria,1KNQC@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Tetratricopeptide repeat - - - ko:K21007 ko02025,map02025 - - - ko00000,ko00001 - - - TPR_15,TPR_19 k59_1134498_2 444860.E3SIQ6_9CAUD 2.24e-110 324.0 4QAX9@10239|Viruses,4QVNY@35237|dsDNA viruses no RNA stage,4QPQH@28883|Caudovirales,4QHWN@10662|Myoviridae 10662|Myoviridae S T4 bacteriophage base plate protein - - - - - - - - - - - - - k59_143493_1 225937.HP15_767 1.45e-122 358.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,464MX@72275|Alteromonadaceae 1236|Gammaproteobacteria J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_186405_1 1234364.AMSF01000015_gene3280 3.94e-14 66.2 COG1551@1|root,COG1551@2|Bacteria,1N6PG@1224|Proteobacteria,1SCB4@1236|Gammaproteobacteria,1X83M@135614|Xanthomonadales 135614|Xanthomonadales J Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA - - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k59_1300779_1 1192034.CAP_1667 1.38e-20 92.0 COG1721@1|root,COG1721@2|Bacteria,1N8IQ@1224|Proteobacteria,42S2K@68525|delta/epsilon subdivisions,2WNA2@28221|Deltaproteobacteria,2YVGE@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_1300779_2 565655.ECBG_00373 1.33e-13 71.6 COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,4HA0T@91061|Bacilli,4B0BS@81852|Enterococcaceae 91061|Bacilli S ATPase family associated with various cellular activities (AAA) moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1179851_1 1229909.NSED_01125 1.14e-131 394.0 COG1204@1|root,arCOG00553@2157|Archaea,41SAK@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks hel308 - - ko:K03726 - - - - ko00000,ko01000 - - - DEAD,HHH_5,Helicase_C k59_1242758_1 570967.JMLV01000007_gene973 1.75e-39 148.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TTBG@28211|Alphaproteobacteria,2JPA6@204441|Rhodospirillales 204441|Rhodospirillales P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC k59_514915_1 330214.NIDE4287 1.68e-101 317.0 COG0205@1|root,COG0406@1|root,COG0205@2|Bacteria,COG0406@2|Bacteria 2|Bacteria G alpha-ribazole phosphatase activity pfkA - 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - His_Phos_1,PFK k59_716070_1 107636.JQNK01000009_gene3513 3.61e-87 270.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,370BU@31993|Methylocystaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_298898_1 1123360.thalar_02506 3.51e-147 421.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_32,rve k59_298898_2 864069.MicloDRAFT_00051360 7.7e-57 181.0 COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria,1JVFR@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_1082513_1 247634.GPB2148_3035 3.5e-26 111.0 29RPH@1|root,32YUD@2|Bacteria,1NFZB@1224|Proteobacteria,1SE5N@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1541286_1 566466.NOR53_181 8.21e-78 237.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1J998@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C SelR domain - - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR,TAT_signal k59_1179856_2 1198232.CYCME_0392 1.38e-22 95.9 COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,1RNZF@1236|Gammaproteobacteria,4613M@72273|Thiotrichales 72273|Thiotrichales S Sodium Bile acid symporter family - - - ko:K03453 - - - - ko00000 2.A.28 - - SBF k59_1300793_1 338963.Pcar_0241 1.6e-19 89.7 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,42P2T@68525|delta/epsilon subdivisions,2WJ9B@28221|Deltaproteobacteria,43S8A@69541|Desulfuromonadales 28221|Deltaproteobacteria JK 16S rRNA methyltransferase RsmB/F rsmB - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_1300793_2 1479239.JQMU01000001_gene2377 1.55e-08 57.4 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2TSWX@28211|Alphaproteobacteria,2K0ZM@204457|Sphingomonadales 204457|Sphingomonadales J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_925965_1 574087.Acear_1156 7.74e-54 191.0 COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,3WA7U@53433|Halanaerobiales 186801|Clostridia L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_716082_1 1049564.TevJSym_be00170 1.03e-20 93.6 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1J4F8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Involved in the TonB-independent uptake of proteins tolB GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019904,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701 - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_1242773_1 1123508.JH636449_gene7382 1.65e-12 70.1 COG0577@1|root,COG0577@2|Bacteria,2IY8W@203682|Planctomycetes 203682|Planctomycetes V Permease component - - - - - - - - - - - - - k59_97616_1 1236542.BALM01000011_gene3895 7.4e-12 70.9 COG1629@1|root,COG4771@2|Bacteria,1MUNK@1224|Proteobacteria,1RN9S@1236|Gammaproteobacteria,2Q9RT@267890|Shewanellaceae 1236|Gammaproteobacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1661687_1 1121033.AUCF01000001_gene1952 1.04e-15 75.5 COG0454@1|root,COG0454@2|Bacteria,1RDGT@1224|Proteobacteria,2TRF5@28211|Alphaproteobacteria,2JSV9@204441|Rhodospirillales 204441|Rhodospirillales K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 k59_1661687_2 639283.Snov_0489 6.64e-38 132.0 COG0454@1|root,COG0456@2|Bacteria,1RA6D@1224|Proteobacteria,2UC27@28211|Alphaproteobacteria,3EZU6@335928|Xanthobacteraceae 28211|Alphaproteobacteria K FR47-like protein - - - - - - - - - - - - Acetyltransf_1 k59_1179881_1 472759.Nhal_3687 2.96e-85 266.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1WW6G@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1134559_1 420246.GTNG_2826 9.23e-16 80.1 COG0338@1|root,COG0338@2|Bacteria,1V1FT@1239|Firmicutes,4HGCH@91061|Bacilli,1WHCW@129337|Geobacillus 91061|Bacilli L Putative phage serine protease XkdF yqbD - - - - - - - - - - - Peptidase_S78_2 k59_1508426_1 1380350.JIAP01000032_gene1026 1.02e-33 131.0 COG1957@1|root,COG1957@2|Bacteria 2|Bacteria F ribosylpyrimidine nucleosidase activity - - - - - - - - - - - - DUF547 k59_870698_1 251229.Chro_4406 4.22e-62 202.0 COG0167@1|root,COG0167@2|Bacteria,1G2B6@1117|Cyanobacteria,3VJ02@52604|Pleurocapsales 1117|Cyanobacteria F Catalyzes the conversion of dihydroorotate to orotate - - 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_716113_3 444860.E3SJ48_9CAUD 1.06e-52 177.0 4QAWG@10239|Viruses,4QV6X@35237|dsDNA viruses no RNA stage,4QPII@28883|Caudovirales,4QI76@10662|Myoviridae 10662|Myoviridae S DNA helicase activity - - - - - - - - - - - - - k59_401534_1 1126627.BAWE01000004_gene2247 7.68e-86 281.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,TPR_8,TolB_N k59_974629_1 1502770.JQMG01000001_gene1116 4.39e-73 228.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VH42@28216|Betaproteobacteria,2KKDW@206350|Nitrosomonadales 206350|Nitrosomonadales V PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_1027027_1 1122599.AUGR01000019_gene3079 4.35e-06 46.6 2DB76@1|root,2Z7JZ@2|Bacteria,1R41X@1224|Proteobacteria,1S1J8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S T4-like virus tail tube protein gp19 - - - - - - - - - - - - Phage_T4_gp19 k59_870711_1 290397.Adeh_3789 2.59e-09 64.3 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2WJ54@28221|Deltaproteobacteria,2YURT@29|Myxococcales 28221|Deltaproteobacteria M Transglycosylase SLT domain mltD2 - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_1336129_1 1198232.CYCME_1299 2.82e-59 203.0 28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,1RN0X@1236|Gammaproteobacteria,461PJ@72273|Thiotrichales 72273|Thiotrichales M Fatty acid cis/trans isomerase (CTI) - - - - - - - - - - - - CTI k59_456694_2 999419.HMPREF1077_02622 4.85e-18 86.7 COG1678@1|root,COG1678@2|Bacteria,4NFQA@976|Bacteroidetes,2FM82@200643|Bacteroidia,22YAY@171551|Porphyromonadaceae 976|Bacteroidetes K Uncharacterized ACR, COG1678 - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_831033_1 1125863.JAFN01000001_gene3058 5.88e-16 83.6 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKFA@28221|Deltaproteobacteria 68525|delta/epsilon subdivisions T response regulator - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_673896_1 1415166.NONO_c42090 1.58e-106 322.0 COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria,4FWVS@85025|Nocardiaceae 201174|Actinobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_831037_1 164757.Mjls_0596 5.97e-14 72.0 COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,233HK@1762|Mycobacteriaceae 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_831037_2 298655.KI912266_gene5931 2.4e-47 166.0 COG0318@1|root,COG0318@2|Bacteria,2GMVB@201174|Actinobacteria,4ESDV@85013|Frankiales 201174|Actinobacteria IQ Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_608551_1 1192034.CAP_2777 1.32e-30 124.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,42M5P@68525|delta/epsilon subdivisions,2WIW8@28221|Deltaproteobacteria,2YUB7@29|Myxococcales 28221|Deltaproteobacteria KL Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_143581_1 1397527.Q670_07900 1.57e-18 86.7 COG0500@1|root,COG2226@2|Bacteria,1RANW@1224|Proteobacteria,1SYQU@1236|Gammaproteobacteria,1XRJY@135619|Oceanospirillales 135619|Oceanospirillales Q COG0500 SAM-dependent methyltransferases - - - - - - - - - - - - Methyltransf_11 k59_1134603_1 1288494.EBAPG3_19770 2.41e-54 192.0 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria,372RG@32003|Nitrosomonadales 28216|Betaproteobacteria E Spermine/spermidine synthase domain - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_515058_1 857087.Metme_0296 7.21e-52 170.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RQQ3@1236|Gammaproteobacteria,1XE8J@135618|Methylococcales 135618|Methylococcales K response regulator - - - ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_97696_1 96561.Dole_3056 6.83e-24 93.2 2E4RC@1|root,32ZJW@2|Bacteria,1N8RU@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_557036_1 1249627.D779_2708 2.7e-17 81.6 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales 135613|Chromatiales G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_1242852_1 765911.Thivi_0715 3.83e-48 173.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1WWF7@135613|Chromatiales 135613|Chromatiales H TonB-dependent Receptor Plug - - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_1082626_1 565045.NOR51B_741 3.5e-62 203.0 COG4240@1|root,COG4240@2|Bacteria,1QUTA@1224|Proteobacteria,1T23W@1236|Gammaproteobacteria,1J90T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG4240 Predicted kinase - - 2.7.1.31 ko:K15918 ko00260,ko00561,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00561,map00630,map01100,map01110,map01130,map01200 M00532 R01514 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ArgK,PRK k59_299021_2 1123368.AUIS01000004_gene120 5.67e-40 148.0 COG2202@1|root,COG3829@1|root,COG4251@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,1T2K7@1236|Gammaproteobacteria,2NDJ6@225057|Acidithiobacillales 1236|Gammaproteobacteria T PAS fold - - - - - - - - - - - - DUF4118,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Phosphonate-bd k59_1391617_1 1236542.BALM01000021_gene1608 9.27e-33 130.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,2Q8XB@267890|Shewanellaceae 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_675667_2 330214.NIDE4140 1.11e-81 241.0 COG1145@1|root,COG1145@2|Bacteria,3J1BF@40117|Nitrospirae 40117|Nitrospirae C 4Fe-4S dicluster domain - - - - - - - - - - - - - k59_1337183_1 1121875.KB907547_gene3470 3.78e-16 81.6 COG0760@1|root,COG0760@2|Bacteria,4P0N3@976|Bacteroidetes,1IABD@117743|Flavobacteriia 976|Bacteroidetes O PPIC-type PPIASE domain - - - - - - - - - - - - Rotamase_2 k59_927312_1 472759.Nhal_0864 6.07e-76 249.0 COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1WXUN@135613|Chromatiales 135613|Chromatiales P TrkA-C domain - - - - - - - - - - - - CitMHS,TrkA_C k59_766835_1 710686.Mycsm_02321 1.4e-61 210.0 COG4548@1|root,COG4548@2|Bacteria,2GIYK@201174|Actinobacteria,234RV@1762|Mycobacteriaceae 201174|Actinobacteria P von willebrand factor type a - - - - - - - - - - - - VWA,VWA_2,VWA_CoxE k59_1663528_1 1530186.JQEY01000001_gene891 1.9e-12 70.5 COG0261@1|root,COG3743@1|root,COG0261@2|Bacteria,COG3743@2|Bacteria,1MZEW@1224|Proteobacteria,2UBT3@28211|Alphaproteobacteria 28211|Alphaproteobacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - HHH_5,Ribosomal_L21p k59_1548816_1 436308.Nmar_0265 1.71e-130 383.0 COG0373@1|root,arCOG01036@2157|Archaea,41SDM@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) - - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,Shikimate_DH k59_1605977_1 443144.GM21_0622 5.6e-36 129.0 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,42TJ2@68525|delta/epsilon subdivisions,2WQ4P@28221|Deltaproteobacteria 28221|Deltaproteobacteria H PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK folK - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK k59_723167_1 891968.Anamo_1392 3.19e-14 72.8 COG1104@1|root,COG1104@2|Bacteria,3TA15@508458|Synergistetes 508458|Synergistetes H Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_409119_1 522306.CAP2UW1_3732 1.27e-39 139.0 COG1392@1|root,COG1392@2|Bacteria,1N4VJ@1224|Proteobacteria 1224|Proteobacteria P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_1089841_1 697282.Mettu_1490 1.51e-84 265.0 COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,1RPTG@1236|Gammaproteobacteria,1XEM6@135618|Methylococcales 135618|Methylococcales F Thymidine phosphorylase - - 2.4.2.4 ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C k59_1548820_1 626887.J057_13006 1.75e-120 353.0 COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,1RQ3E@1236|Gammaproteobacteria,46BQ5@72275|Alteromonadaceae 1236|Gammaproteobacteria U Cation efflux family catA - - - - - - - - - - - Cation_efflux,ZT_dimer k59_1034029_1 436308.Nmar_0657 6.52e-97 294.0 COG1262@1|root,arCOG03517@2157|Archaea,41T1B@651137|Thaumarchaeota 651137|Thaumarchaeota S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase k59_1342365_2 1469245.JFBG01000013_gene1948 3.59e-33 116.0 COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,1S9MD@1236|Gammaproteobacteria,1WYWM@135613|Chromatiales 135613|Chromatiales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_1342365_3 1009858.BUMPG002_CDS00583 1.97e-08 53.1 COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,1S402@1236|Gammaproteobacteria,37DAP@32199|Buchnera 1236|Gammaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpF GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902600 - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - e_coli_core.b3736,iAF1260.b3736,iB21_1397.B21_03564,iBWG_1329.BWG_3427,iE2348C_1286.E2348C_4046,iEC042_1314.EC042_4123,iEC55989_1330.EC55989_4211,iECABU_c1320.ECABU_c42210,iECBD_1354.ECBD_4296,iECB_1328.ECB_03620,iECDH10B_1368.ECDH10B_3923,iECDH1ME8569_1439.ECDH1ME8569_3624,iECD_1391.ECD_03620,iECED1_1282.ECED1_4426,iECH74115_1262.ECH74115_5172,iECIAI1_1343.ECIAI1_3920,iECIAI39_1322.ECIAI39_4340,iECO103_1326.ECO103_4422,iECO111_1330.ECO111_4570,iECO26_1355.ECO26_4842,iECOK1_1307.ECOK1_4185,iECP_1309.ECP_3935,iECS88_1305.ECS88_4158,iECSE_1348.ECSE_4026,iECSF_1327.ECSF_3584,iECSP_1301.ECSP_4786,iECUMN_1333.ECUMN_4266,iECW_1372.ECW_m4039,iECs_1301.ECs4678,iEKO11_1354.EKO11_4609,iETEC_1333.ETEC_4027,iEcDH1_1363.EcDH1_4231,iEcE24377_1341.EcE24377A_4252,iEcHS_1320.EcHS_A3952,iEcSMS35_1347.EcSMS35_4104,iEcolC_1368.EcolC_4258,iG2583_1286.G2583_4532,iJO1366.b3736,iJR904.b3736,iSDY_1059.SDY_4012,iSFV_1184.SFV_3762,iSF_1195.SF3816,iSFxv_1172.SFxv_4159,iSSON_1240.SSON_3883,iS_1188.S3952,iSbBS512_1146.SbBS512_E4185,iUMN146_1321.UM146_18870,iUMNK88_1353.UMNK88_4548,iUTI89_1310.UTI89_C4291,iWFL_1372.ECW_m4039,iY75_1357.Y75_RS18390,iZ_1308.Z5234,ic_1306.c4664 ATP-synt_B k59_979757_1 1123247.AUIJ01000007_gene2840 2.77e-31 124.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TTBD@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_772340_2 631362.Thi970DRAFT_04624 2.35e-58 182.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,1WYQC@135613|Chromatiales 135613|Chromatiales J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT - - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_149998_1 765910.MARPU_03820 3.09e-80 252.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1WWJA@135613|Chromatiales 135613|Chromatiales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_1249181_1 861299.J421_0542 7.61e-05 44.3 COG3576@1|root,COG3576@2|Bacteria 2|Bacteria S Pyridoxamine 5'-phosphate oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_1249181_2 1122611.KB903953_gene5729 1.34e-26 106.0 COG0436@1|root,COG0436@2|Bacteria,2GTYR@201174|Actinobacteria 201174|Actinobacteria E Aminotransferase - - 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - - - k59_1186158_1 156889.Mmc1_2523 7.5e-19 85.5 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1186158_2 1235803.C825_01912 1.17e-11 68.2 COG0845@1|root,COG0845@2|Bacteria,4NERP@976|Bacteroidetes,2FQSG@200643|Bacteroidia,22W5U@171551|Porphyromonadaceae 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23,OEP k59_1456472_1 1229909.NSED_00415 4.07e-58 184.0 COG4276@1|root,arCOG04604@2157|Archaea,41SI9@651137|Thaumarchaeota 651137|Thaumarchaeota S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - Polyketide_cyc2 k59_19972_1 754476.Q7A_781 1.2e-77 247.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,460FW@72273|Thiotrichales 72273|Thiotrichales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_19972_2 1026882.MAMP_01505 2.93e-70 226.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,45ZZA@72273|Thiotrichales 72273|Thiotrichales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_564055_1 765911.Thivi_3833 1.58e-44 157.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1WWCM@135613|Chromatiales 135613|Chromatiales M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_564055_2 856793.MICA_1263 3.22e-11 65.5 COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,2TUER@28211|Alphaproteobacteria,4BQ69@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_1548907_1 330214.NIDE0397 1.04e-58 187.0 COG0036@1|root,COG0036@2|Bacteria,3J0IZ@40117|Nitrospirae 40117|Nitrospirae G Ribulose-phosphate 3 epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_933520_1 330214.NIDE4367 2.85e-64 210.0 COG0312@1|root,COG0312@2|Bacteria 2|Bacteria S metallopeptidase activity tldE2 - - - - - - - - - - - PmbA_TldD k59_772396_1 1207076.ALAT01000028_gene166 4.23e-159 462.0 COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,1RQA2@1236|Gammaproteobacteria,1Z1N4@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - HTH_23,HTH_24,rve k59_723269_1 203122.Sde_1799 1.07e-41 146.0 COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,1RR85@1236|Gammaproteobacteria,464V9@72275|Alteromonadaceae 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrC - 1.6.5.8 ko:K00348 - - - - ko00000,ko01000 - - - FMN_bind k59_723269_2 1415778.JQMM01000001_gene1915 1.6e-15 74.3 COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,1J4TB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrD GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015672,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030001,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0051179,GO:0051234,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.6.5.8 ko:K00349 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_933541_1 1449065.JMLL01000011_gene2197 5.62e-13 75.1 COG0421@1|root,COG0421@2|Bacteria,1PC07@1224|Proteobacteria,2UZTQ@28211|Alphaproteobacteria,43QFC@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - - k59_979873_1 330214.NIDE1362 4.27e-33 127.0 COG2844@1|root,COG2844@2|Bacteria 2|Bacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.42,2.7.7.59,2.7.7.89 ko:K00982,ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_979873_2 330214.NIDE1363 4.55e-78 244.0 COG0174@1|root,COG0174@2|Bacteria,3J0AS@40117|Nitrospirae 40117|Nitrospirae E Glutamine synthetase, catalytic domain glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_1089969_1 156889.Mmc1_2884 1.41e-17 75.9 2C16Q@1|root,330H3@2|Bacteria,1NB82@1224|Proteobacteria,2UGE6@28211|Alphaproteobacteria 28211|Alphaproteobacteria S HicB family - - - - - - - - - - - - HicB k59_358385_1 396588.Tgr7_2633 6.23e-82 248.0 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1WW35@135613|Chromatiales 135613|Chromatiales L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_358385_2 396588.Tgr7_2638 4.68e-21 87.4 2AFCJ@1|root,315C6@2|Bacteria,1RH66@1224|Proteobacteria,1S9MI@1236|Gammaproteobacteria,1WYGK@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF1841) - - - - - - - - - - - - DUF1841 k59_1606070_2 1304885.AUEY01000021_gene3465 2.78e-32 116.0 COG2050@1|root,COG2050@2|Bacteria,1N5HF@1224|Proteobacteria,42RQZ@68525|delta/epsilon subdivisions,2WNIY@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q PFAM thioesterase superfamily - - - - - - - - - - - - 4HBT k59_1397939_1 1348662.CARG_06875 1.74e-20 93.2 COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,22KTV@1653|Corynebacteriaceae 201174|Actinobacteria C Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) component and related enzymes sucB GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005504,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008289,GO:0009405,GO:0009987,GO:0015036,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0030312,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0040007,GO:0042592,GO:0043167,GO:0043168,GO:0043177,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0045454,GO:0048037,GO:0050662,GO:0050789,GO:0050794,GO:0051704,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1397939_2 517418.Ctha_2180 9.45e-59 199.0 COG1249@1|root,COG1249@2|Bacteria,1FDB4@1090|Chlorobi 1090|Chlorobi C pyridine nucleotide-disulphide oxidoreductase dimerisation region - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_1342485_1 1380394.JADL01000017_gene493 1.22e-25 107.0 COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,2TSVE@28211|Alphaproteobacteria,2JQ2G@204441|Rhodospirillales 204441|Rhodospirillales C FAD binding domain - - 1.1.3.8 ko:K00103 ko00053,ko01100,map00053,map01100 M00129 R00647,R03184,R10053 RC00195,RC00346,RC00869 ko00000,ko00001,ko00002,ko01000 - - - ALO,FAD_binding_4 k59_616230_1 1232410.KI421425_gene1553 2.01e-78 257.0 COG4932@1|root,COG4932@2|Bacteria,1QZFW@1224|Proteobacteria 1224|Proteobacteria M domain protein - - - - - - - - - - - - DUF11,SdrD_B k59_409271_1 388051.AUFE01000015_gene5970 5.54e-64 202.0 COG1802@1|root,COG1802@2|Bacteria,1MXNF@1224|Proteobacteria,2VKBY@28216|Betaproteobacteria,1K4DZ@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - FCD,GntR k59_1089990_1 1095769.CAHF01000013_gene3259 8.52e-72 240.0 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,4726K@75682|Oxalobacteraceae 28216|Betaproteobacteria E Domain of unknown function (DUF3488) - - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_1186270_1 744980.TRICHSKD4_5835 5.95e-25 102.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2TR87@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_410360_1 1128421.JAGA01000002_gene959 6.64e-27 105.0 COG1595@1|root,COG1595@2|Bacteria,2NPRC@2323|unclassified Bacteria 2|Bacteria K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_773193_1 519989.ECTPHS_08226 5.45e-103 310.0 COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,1RMGC@1236|Gammaproteobacteria,1WWQU@135613|Chromatiales 135613|Chromatiales E Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B k59_359319_1 1026882.MAMP_00769 2.36e-65 225.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,45ZWV@72273|Thiotrichales 72273|Thiotrichales E Glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_464862_1 589865.DaAHT2_0128 8.52e-94 286.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria,2MISS@213118|Desulfobacterales 28221|Deltaproteobacteria P Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_1187304_1 1183377.Py04_1176 1.67e-26 103.0 COG1832@1|root,arCOG04227@2157|Archaea,2XXS6@28890|Euryarchaeota,2440Z@183968|Thermococci 183968|Thermococci S CoA binding domain - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 k59_1187304_2 1118058.CAGY01000005_gene1027 2.58e-18 84.0 COG2873@1|root,COG2873@2|Bacteria,2I2EB@201174|Actinobacteria,4D4KB@85005|Actinomycetales 201174|Actinobacteria E O-acetylhomoserine aminocarboxypropyltransferase cysteine synthase metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_20436_1 1268239.PALB_27010 6.56e-12 68.2 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,2Q11Y@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria O Belongs to the ClpA ClpB family clpA GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_20436_2 360910.BAV2091 1.25e-25 99.4 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2VSCU@28216|Betaproteobacteria,3T4GI@506|Alcaligenaceae 28216|Betaproteobacteria S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_20436_3 1192759.AKIB01000005_gene178 6.64e-11 63.2 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2TS5I@28211|Alphaproteobacteria,2K1NQ@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_1343556_1 1121271.AUCM01000022_gene3088 6.16e-41 154.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cusA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_1457595_1 247634.GPB2148_2901 2.56e-50 172.0 COG0404@1|root,COG0404@2|Bacteria,1N705@1224|Proteobacteria,1S5H7@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the GcvT family - - - - - - - - - - - - GCV_T,GCV_T_C k59_359336_1 1206744.BAGL01000124_gene6534 3.71e-26 105.0 COG0657@1|root,COG0657@2|Bacteria,2GJYR@201174|Actinobacteria,4FY44@85025|Nocardiaceae 201174|Actinobacteria I Carboxylesterase family - - - - - - - - - - - - Abhydrolase_3 k59_359336_2 1299327.I546_2830 1.01e-66 212.0 COG0683@1|root,COG0683@2|Bacteria,2IAAV@201174|Actinobacteria,234EA@1762|Mycobacteriaceae 201174|Actinobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - - - - - - - - - - Peripla_BP_6 k59_1091095_1 748658.KB907312_gene1881 8.82e-20 90.5 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales 135613|Chromatiales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_1091095_2 686340.Metal_1862 3.97e-34 125.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,1XDMU@135618|Methylococcales 135618|Methylococcales J glycyl-tRNA synthetase glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_1549999_1 1229909.NSED_05300 2.49e-33 124.0 COG1378@1|root,arCOG02038@2157|Archaea 2157|Archaea K transcriptional - - - - - - - - - - - - Regulator_TrmB,TrmB k59_1549999_2 436308.Nmar_0333 2.22e-07 55.1 arCOG08778@1|root,arCOG08778@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1187335_1 661367.LLO_2332 5.26e-62 207.0 COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,1RY9G@1236|Gammaproteobacteria,1JE37@118969|Legionellales 118969|Legionellales C Aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1250401_1 1293047.CBMA010000054_gene3530 1.98e-39 147.0 COG0438@1|root,arCOG01410@2157|Archaea,2Y8BF@28890|Euryarchaeota,24181@183963|Halobacteria 183963|Halobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_4_4,Glycos_transf_1 k59_1143744_1 268746.Q58MP1_BPPRM 3.9e-67 230.0 4QEE7@10239|Viruses,4QV59@35237|dsDNA viruses no RNA stage,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae 10662|Myoviridae S Pfam:DUF4815 - - - - - - - - - - - - - k59_151252_1 1049564.TevJSym_bk00120 1.26e-06 49.7 COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,1SAW8@1236|Gammaproteobacteria 1236|Gammaproteobacteria T dksA traR - - - - - - - - - - - - zf-dskA_traR k59_410437_1 1255043.TVNIR_1179 3.09e-88 269.0 COG1335@1|root,COG1335@2|Bacteria,1RCGZ@1224|Proteobacteria,1SPB0@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1335 Amidases related to nicotinamidase - - - - - - - - - - - - - k59_195327_1 1341157.RF007C_05085 1.09e-18 90.9 COG0318@1|root,COG1082@1|root,COG0318@2|Bacteria,COG1082@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,3WHKA@541000|Ruminococcaceae 186801|Clostridia GIQ AMP-dependent synthetase - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C,AP_endonuc_2 k59_1143750_1 240016.ABIZ01000001_gene5866 1.5e-80 250.0 COG0468@1|root,COG0468@2|Bacteria,46SIZ@74201|Verrucomicrobia,2ITWB@203494|Verrucomicrobiae 203494|Verrucomicrobiae L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_410439_1 1120705.FG95_00811 2.65e-54 184.0 COG3239@1|root,COG3239@2|Bacteria,1MVY5@1224|Proteobacteria,2U156@28211|Alphaproteobacteria,2K0CR@204457|Sphingomonadales 204457|Sphingomonadales I Fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_1457648_1 1040989.AWZU01000001_gene5816 2.76e-83 264.0 COG2159@1|root,COG2159@2|Bacteria,1Q4XY@1224|Proteobacteria,2U25S@28211|Alphaproteobacteria,3JUPG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Amidohydrolase - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_307434_1 644107.SL1157_2464 1.44e-11 65.1 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2TQUE@28211|Alphaproteobacteria,4N9ZQ@97050|Ruegeria 28211|Alphaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_307434_2 1462526.BN990_04084 3.91e-17 75.9 COG1828@1|root,COG1828@2|Bacteria,1VEH1@1239|Firmicutes,4HP0E@91061|Bacilli,4C6XE@84406|Virgibacillus 91061|Bacilli F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purS - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU06460 PurS k59_307434_3 502025.Hoch_3843 1.1e-71 226.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WJY0@28221|Deltaproteobacteria,2YUIU@29|Myxococcales 28221|Deltaproteobacteria F Belongs to the SAICAR synthetase family purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_617426_2 999541.bgla_2g17650 2.78e-169 488.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2VHQ8@28216|Betaproteobacteria,1K0H7@119060|Burkholderiaceae 28216|Betaproteobacteria E Amidase, hydantoinase carbamoylase family - - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_206679_1 1254432.SCE1572_06940 1.07e-42 154.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2WJVZ@28221|Deltaproteobacteria,2YU94@29|Myxococcales 28221|Deltaproteobacteria T GTP-binding protein typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_206679_2 448385.sce1812 2.24e-35 124.0 2A4R8@1|root,30TCM@2|Bacteria,1PD5K@1224|Proteobacteria,43DYZ@68525|delta/epsilon subdivisions,2WZ8R@28221|Deltaproteobacteria,2Z1KF@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - TerB k59_886025_1 622637.KE124770_gene178 2.98e-75 259.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,36ZDR@31993|Methylocystaceae 28211|Alphaproteobacteria P Cation transporter/ATPase, N-terminus - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,HlyD_D23,Hydrolase,Hydrolase_3 k59_1353543_1 580332.Slit_0530 6.43e-85 275.0 COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria 28216|Betaproteobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,Pkinase k59_1408928_1 1229909.NSED_01470 4.38e-42 139.0 arCOG08781@1|root,arCOG08781@2157|Archaea,41SVY@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1613718_1 1122135.KB893146_gene1787 9.91e-15 72.8 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the GcvT family sardh - 1.5.3.19 ko:K19191 ko00760,ko01120,map00760,map01120 - R10102 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO,FAO_M,GCV_T,GCV_T_C k59_1042450_1 765914.ThisiDRAFT_1039 5.83e-77 249.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1WWD1@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_573035_1 1340493.JNIF01000003_gene4344 1.95e-08 61.2 28JZQ@1|root,2Z9PN@2|Bacteria,3Y4UW@57723|Acidobacteria 57723|Acidobacteria - - - - - - - - - - - - - - - k59_573038_2 316055.RPE_3196 4.71e-26 106.0 COG1853@1|root,COG1853@2|Bacteria,1MZKY@1224|Proteobacteria,2U22K@28211|Alphaproteobacteria,3JSX3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct k59_573038_3 1125973.JNLC01000014_gene2391 3.61e-92 288.0 COG1960@1|root,COG1960@2|Bacteria,1MW97@1224|Proteobacteria,2TUS1@28211|Alphaproteobacteria,3JRWA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MA20_38160 - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_24268_1 472175.EL18_00102 4.58e-89 281.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2TSSI@28211|Alphaproteobacteria,43GSS@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I AMP-binding enzyme fadD3 - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_260024_1 640511.BC1002_5549 2.75e-27 113.0 COG3115@1|root,COG3115@2|Bacteria,1QVM5@1224|Proteobacteria,2WI17@28216|Betaproteobacteria,1KG8X@119060|Burkholderiaceae 28216|Betaproteobacteria D Protein of unknown function (DUF3300) - - - - - - - - - - - - DUF3300 k59_260028_1 1480694.DC28_10430 6.07e-08 60.5 COG0475@1|root,COG0475@2|Bacteria,2J5WC@203691|Spirochaetes 203691|Spirochaetes P Sodium hydrogen exchanger family - - - - - - - - - - - - CBS,Na_H_Exchanger k59_886095_1 1173027.Mic7113_3377 2.28e-17 85.5 COG0745@1|root,COG2114@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG5002@2|Bacteria,1GHFQ@1117|Cyanobacteria,1H9WN@1150|Oscillatoriales 1117|Cyanobacteria T 7TM diverse intracellular signalling - - - ko:K19694 - - - - ko00000,ko01001,ko02022 - - - 7TMR-DISM_7TM,Guanylate_cyc,HAMP,HATPase_c,HisKA,PAS_9,Response_reg,dCache_1 k59_1561328_1 330214.NIDE2582 1.32e-80 270.0 COG0587@1|root,COG0587@2|Bacteria,3J0FE@40117|Nitrospirae 40117|Nitrospirae L DNA-directed DNA polymerase - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_573072_1 1227454.C446_01773 2.64e-110 352.0 COG5013@1|root,arCOG01497@2157|Archaea,2XUSJ@28890|Euryarchaeota,23UWV@183963|Halobacteria 183963|Halobacteria C Molybdopterin oxidoreductase - - 1.7.5.1 ko:K00370 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Molybdopterin k59_1561344_2 204669.Acid345_2552 1.67e-20 95.1 COG0845@1|root,COG0845@2|Bacteria,3Y43R@57723|Acidobacteria,2JIK4@204432|Acidobacteriia 204432|Acidobacteriia M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_1409025_1 713586.KB900536_gene1702 1.26e-32 118.0 COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,1S6WA@1236|Gammaproteobacteria,1WXPI@135613|Chromatiales 135613|Chromatiales F phosphoribosyltransferase pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran k59_1353641_1 768671.ThimaDRAFT_2775 2.17e-55 181.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1WWX5@135613|Chromatiales 135613|Chromatiales S associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1353641_2 1049564.TevJSym_bh00130 1.28e-52 173.0 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1J5XC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_1561394_1 1049564.TevJSym_at00270 1.33e-45 162.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1J4S5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG4942 Membrane-bound metallopeptidase envC GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 - - - - - - - - - - Peptidase_M23 k59_260071_1 998674.ATTE01000001_gene2582 9.83e-77 245.0 COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,1RP55@1236|Gammaproteobacteria,45ZZW@72273|Thiotrichales 72273|Thiotrichales P PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_1561400_1 672.VV93_v1c33530 4.8e-12 65.1 COG0515@1|root,COG0515@2|Bacteria,1N79H@1224|Proteobacteria,1SC5K@1236|Gammaproteobacteria,1XUYG@135623|Vibrionales 135623|Vibrionales KLT Protein of unknown function (DUF1566) - - - - - - - - - - - - DUF1566 k59_25037_2 536019.Mesop_0257 1.19e-22 97.4 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TU0K@28211|Alphaproteobacteria,43HE3@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - - - - - - - - - - MerB,Pyr_redox_2,Pyr_redox_dim k59_1199383_1 1033802.SSPSH_000958 1.81e-27 112.0 COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,1RNZF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bile acid sodium symporter - - - ko:K03453 - - - - ko00000 2.A.28 - - SBF k59_1044387_2 994479.GL877878_gene1684 2.06e-23 94.4 COG1586@1|root,COG1586@2|Bacteria,2IMGV@201174|Actinobacteria,4E4X8@85010|Pseudonocardiales 201174|Actinobacteria H Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speH - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc k59_1044387_3 869724.H6BI87_9CAUD 1.25e-59 184.0 4QAYY@10239|Viruses,4QY2K@35237|dsDNA viruses no RNA stage,4QTYB@28883|Caudovirales,4QIMP@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_782696_1 1121346.KB899837_gene1251 6.33e-14 73.6 COG1622@1|root,COG1622@2|Bacteria,1TPMD@1239|Firmicutes,4HGXU@91061|Bacilli,26XKH@186822|Paenibacillaceae 91061|Bacilli C Cytochrome C oxidase subunit II, periplasmic domain - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2 k59_1044404_1 228405.HNE_2706 3.53e-50 174.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,43WT2@69657|Hyphomonadaceae 28211|Alphaproteobacteria I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation MA20_05130 - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_782717_1 1183438.GKIL_1793 2.15e-45 157.0 COG1063@1|root,COG1063@2|Bacteria,1FZZE@1117|Cyanobacteria 1117|Cyanobacteria E PFAM Alcohol dehydrogenase - - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N,Shikimate_DH k59_25066_1 502025.Hoch_1780 5.24e-86 276.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2WJG7@28221|Deltaproteobacteria,2YUAP@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_1564302_1 391165.GbCGDNIH1_0514 2.35e-107 320.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2TVCY@28211|Alphaproteobacteria,2JRV7@204441|Rhodospirillales 204441|Rhodospirillales J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_1044435_1 1510531.JQJJ01000014_gene4690 1.54e-14 75.1 COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2UQ0A@28211|Alphaproteobacteria,3JYUS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S MmgE/PrpD family - - - - - - - - - - - - MmgE_PrpD k59_1044435_2 1121430.JMLG01000004_gene950 6.11e-33 119.0 COG5496@1|root,COG5496@2|Bacteria,1VAZJ@1239|Firmicutes,24MWR@186801|Clostridia,2622Z@186807|Peptococcaceae 186801|Clostridia S THIoesterase - - 3.1.2.29 ko:K18700 - - - - ko00000,ko01000 - - - 4HBT k59_1044435_3 157783.LK03_10355 1.32e-30 121.0 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,1RPP2@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1564363_1 1304885.AUEY01000050_gene1206 1.61e-12 67.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2WJ7H@28221|Deltaproteobacteria,2MIPF@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - AIRC,GARS_A,GARS_C,GARS_N k59_1564363_2 1232410.KI421421_gene3833 1.7e-40 139.0 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,42QTK@68525|delta/epsilon subdivisions,2WPG2@28221|Deltaproteobacteria,43SG8@69541|Desulfuromonadales 28221|Deltaproteobacteria F AIR carboxylase purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_1199479_1 323261.Noc_2712 3e-34 126.0 COG2105@1|root,COG2105@2|Bacteria,1RHE8@1224|Proteobacteria,1S708@1236|Gammaproteobacteria,1WZ0H@135613|Chromatiales 135613|Chromatiales S AIG2-like family - - - - - - - - - - - - AIG2_2 k59_1355465_1 876044.IMCC3088_2347 3.17e-31 120.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria P phosphate transporter pitA GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_1355465_2 314225.ELI_00335 3.81e-24 101.0 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,2TSXW@28211|Alphaproteobacteria,2K1KD@204457|Sphingomonadales 204457|Sphingomonadales G COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_25091_1 288705.RSal33209_1036 2.54e-63 209.0 COG0673@1|root,COG0673@2|Bacteria 2|Bacteria S inositol 2-dehydrogenase activity - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_1564403_1 414684.RC1_3089 4e-49 170.0 COG4398@1|root,COG4398@2|Bacteria,1MUX9@1224|Proteobacteria,2TUXU@28211|Alphaproteobacteria,2JQHF@204441|Rhodospirillales 204441|Rhodospirillales S FIST_C - - - - - - - - - - - - FIST,FIST_C k59_1199501_1 1298867.AUES01000051_gene4511 8.01e-53 191.0 COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - FG-GAP,HemolysinCabind k59_1044505_1 439235.Dalk_4738 1.22e-86 283.0 COG0532@1|root,COG3064@1|root,COG0532@2|Bacteria,COG3064@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MIGT@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_1044545_1 209285.XP_006692078.1 6.78e-22 95.9 COG0076@1|root,KOG1383@2759|Eukaryota,38HST@33154|Opisthokonta,3NUJY@4751|Fungi,3QN1N@4890|Ascomycota,213J4@147550|Sordariomycetes,3U5H0@5139|Sordariales,3HEPY@35718|Chaetomiaceae 4751|Fungi E Belongs to the group II decarboxylase family - - 4.1.1.15 ko:K01580 ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940 M00027 R00261,R00489,R01682,R02466 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Pyridoxal_deC k59_1044549_1 595460.RRSWK_05517 2.59e-45 159.0 COG0714@1|root,COG0714@2|Bacteria,2IX23@203682|Planctomycetes 203682|Planctomycetes S PFAM ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1564508_1 1033734.CAET01000029_gene4588 2.1e-18 91.7 COG1404@1|root,COG1404@2|Bacteria,1TSRI@1239|Firmicutes,4HBFB@91061|Bacilli,1ZCQD@1386|Bacillus 91061|Bacilli O Subtilase family - - 3.4.21.62 ko:K01342 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Peptidase_S8 k59_1355535_1 876044.IMCC3088_2847 7.49e-33 126.0 COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,1RPIT@1236|Gammaproteobacteria,1J68N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily - - 4.2.1.6 ko:K01684 ko00052,ko01100,ko01120,map00052,map01100,map01120 M00552 R03033 RC00543 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_1564542_1 395493.BegalDRAFT_0090 4.09e-102 304.0 COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,1RMR5@1236|Gammaproteobacteria,46076@72273|Thiotrichales 72273|Thiotrichales G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate - - - - - - - - - - - - PEP_mutase k59_1044594_1 1229909.NSED_00570 1.24e-143 412.0 COG0136@1|root,arCOG00494@2157|Archaea,41SFD@651137|Thaumarchaeota 651137|Thaumarchaeota E aspartate-semialdehyde dehydrogenase - - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1044594_2 1131266.ARWQ01000009_gene955 1.66e-57 190.0 COG0079@1|root,arCOG04273@2157|Archaea,41SGU@651137|Thaumarchaeota 651137|Thaumarchaeota E PFAM Aminotransferase class I and II - - 4.1.1.81 ko:K04720 ko00860,map00860 - R06530 RC00517 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_1564576_1 436308.Nmar_0547 1.58e-21 91.7 COG0082@1|root,arCOG04133@2157|Archaea,41SC3@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_1564576_2 436308.Nmar_0546 4.31e-56 187.0 COG0436@1|root,COG1605@1|root,arCOG01130@2157|Archaea,arCOG02098@2157|Archaea,41SBV@651137|Thaumarchaeota 651137|Thaumarchaeota E Chorismate mutase type II - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2,CM_2 k59_25155_2 1266925.JHVX01000001_gene2629 3.1e-42 155.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,37225@32003|Nitrosomonadales 28216|Betaproteobacteria IQ AMP-dependent synthetase - - - - - - - - - - - - AMP-binding,Acyltransferase,PP-binding k59_1564618_1 1348657.M622_02765 8.81e-55 183.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,2KXPJ@206389|Rhodocyclales 28216|Betaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_782950_1 592316.Pat9b_0004 1.46e-32 125.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,3VXUK@53335|Pantoea 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_782950_2 1260251.SPISAL_00015 8.7e-15 76.3 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria,1WYPF@135613|Chromatiales 135613|Chromatiales L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - AAA_23,SMC_N k59_1564649_1 1123261.AXDW01000017_gene3179 2.4e-32 127.0 COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,1X4TB@135614|Xanthomonadales 135614|Xanthomonadales M (Lipo)protein - - - ko:K07121 - - - - ko00000 - - - LppC k59_1355621_1 1042377.AFPJ01000034_gene2320 3.95e-48 174.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RNWM@1236|Gammaproteobacteria,465X0@72275|Alteromonadaceae 1236|Gammaproteobacteria S exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1564675_1 488538.SAR116_0387 1.6e-92 291.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria,4BP86@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_1199659_1 472759.Nhal_1619 4.39e-13 68.2 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,1X01G@135613|Chromatiales 135613|Chromatiales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_783023_1 322710.Avin_44060 3.93e-102 326.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1199712_1 391589.RGAI101_3141 3.1e-32 124.0 arCOG09486@1|root,2ZC3Y@2|Bacteria,1RD8N@1224|Proteobacteria,2U07K@28211|Alphaproteobacteria,2P2NM@2433|Roseobacter 28211|Alphaproteobacteria H Glycosyl transferase family 11 - - - - - - - - - - - - Glyco_transf_11 k59_1199731_1 861299.J421_5600 1.4e-57 190.0 COG1172@1|root,COG1172@2|Bacteria,1ZUX9@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Branched-chain amino acid transport system / permease component - - - ko:K10440,ko:K10553 ko02010,map02010 M00212,M00218 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.7 - - BPD_transp_2 k59_25210_2 1192124.LIG30_0768 3.45e-33 124.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2VHBP@28216|Betaproteobacteria,1K3AU@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_1564838_1 717772.THIAE_00490 4.61e-64 202.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,460PM@72273|Thiotrichales 72273|Thiotrichales F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_1564863_2 1408452.JAGZ01000005_gene1278 1.65e-40 142.0 COG1024@1|root,COG1024@2|Bacteria,2HEIS@201174|Actinobacteria,237CX@1762|Mycobacteriaceae 201174|Actinobacteria I Enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 k59_1564868_1 935948.KE386495_gene1616 2.9e-41 149.0 COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,24898@186801|Clostridia,42GD3@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_522563_1 1125863.JAFN01000001_gene1090 5.81e-63 214.0 COG0618@1|root,COG0618@2|Bacteria,1N0JS@1224|Proteobacteria,42P1S@68525|delta/epsilon subdivisions,2WJV0@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM phosphoesterase, RecJ domain protein - - - - - - - - - - - - DHH,DHHA1 k59_522564_1 268746.Q58MN4_BPPRM 5.5e-89 268.0 4QDYQ@10239|Viruses,4QVVQ@35237|dsDNA viruses no RNA stage,4QPVQ@28883|Caudovirales,4QKJF@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_52526_1 1469245.JFBG01000040_gene1740 1.65e-28 111.0 COG1556@1|root,COG1556@2|Bacteria,1RJ6A@1224|Proteobacteria,1S7WZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S LUD domain ykgG - - ko:K00782 - - - - ko00000 - - iECO111_1330.ECO111_0342,iECO26_1355.ECO26_0342 LUD_dom k59_52526_2 1469245.JFBG01000040_gene1739 6.17e-59 197.0 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,1RQEA@1236|Gammaproteobacteria,1WXT5@135613|Chromatiales 135613|Chromatiales C LUD domain - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_365957_1 1232437.KL661988_gene100 6.71e-14 72.4 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WJ0U@28221|Deltaproteobacteria,2MI24@213118|Desulfobacterales 28221|Deltaproteobacteria E aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 k59_365957_2 997346.HMPREF9374_0087 2.95e-38 135.0 COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,4HBXZ@91061|Bacilli,27BMU@186824|Thermoactinomycetaceae 91061|Bacilli D Ferrous iron transport protein B engB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_992721_1 283942.IL0315 2.79e-93 282.0 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,1RNGM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S nadp-dependent - - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N k59_209151_1 1415779.JOMH01000001_gene3049 4.15e-78 251.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,1X33U@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_365958_1 1249627.D779_1958 1.95e-38 137.0 COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,1S3NR@1236|Gammaproteobacteria,1WY99@135613|Chromatiales 135613|Chromatiales H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE - 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE k59_365958_2 765911.Thivi_3900 1.46e-14 73.6 COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,1WWH6@135613|Chromatiales 135613|Chromatiales D Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity zapD - - ko:K18778 - - - - ko00000,ko03036 - - - ZapD k59_365960_1 1380600.AUYN01000001_gene2393 0.000389 48.9 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,1HYJJ@117743|Flavobacteriia 976|Bacteroidetes M Tricorn protease homolog - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,PDZ,PDZ_2,Peptidase_S41,Tricorn_C1,Tricorn_PDZ k59_1619513_1 330214.NIDE0421 2.11e-93 281.0 COG2876@1|root,COG2876@2|Bacteria,3J0A5@40117|Nitrospirae 40117|Nitrospirae E NeuB family - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_156882_1 522306.CAP2UW1_1421 2.54e-38 142.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VIBU@28216|Betaproteobacteria 28216|Betaproteobacteria M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_679393_1 583355.Caka_1747 2.78e-44 159.0 COG0265@1|root,COG0265@2|Bacteria,46UAN@74201|Verrucomicrobia 74201|Verrucomicrobia O PFAM peptidase S1 and S6 chymotrypsin Hap - - - - - - - - - - - - PDZ_2,Trypsin_2 k59_1201731_1 617140.AJZE01000016_gene4028 5.61e-75 243.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,1RPU5@1236|Gammaproteobacteria,1XVCC@135623|Vibrionales 135623|Vibrionales P COG0471 Di- and tricarboxylate transporters - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_365968_1 479434.Sthe_2885 6.68e-71 224.0 COG0559@1|root,COG0559@2|Bacteria,2G8MW@200795|Chloroflexi,27YY1@189775|Thermomicrobia 189775|Thermomicrobia E Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1149402_1 1229172.JQFA01000002_gene2911 1.28e-107 337.0 COG1048@1|root,COG1048@2|Bacteria,1G4YR@1117|Cyanobacteria,1HBP3@1150|Oscillatoriales 1117|Cyanobacteria C Aconitase C-terminal domain - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_470344_1 671143.DAMO_0297 4.11e-39 147.0 COG5617@1|root,COG5617@2|Bacteria 2|Bacteria M Psort location CytoplasmicMembrane, score - - - - - - - - - - - - YfhO k59_679400_1 1121378.KB899728_gene4132 7.12e-92 285.0 COG1249@1|root,COG1249@2|Bacteria,1WI3A@1297|Deinococcus-Thermus 2|Bacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) sthA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.6.1.1 ko:K00322 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_992745_1 1125779.HMPREF1219_00905 1.55e-19 89.7 COG0107@1|root,COG0107@2|Bacteria,2GIRP@201174|Actinobacteria,22JQJ@1653|Corynebacteriaceae 201174|Actinobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007 4.1.3.27 ko:K01657,ko:K02500 ko00340,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00340,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023,M00026 R00985,R00986,R04558 RC00010,RC01190,RC01943,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_1149411_1 351016.RAZWK3B_13899 2.05e-32 128.0 COG5652@1|root,COG5652@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - VanZ k59_1149411_2 997296.PB1_07587 2.13e-14 76.6 COG0661@1|root,COG0661@2|Bacteria,1TPIV@1239|Firmicutes,4HBW3@91061|Bacilli,1ZBPH@1386|Bacillus 91061|Bacilli S ABC1 family ubiB - - ko:K03688 - - - - ko00000 - - - ABC1,APH k59_522592_1 1005048.CFU_2012 1.3e-28 111.0 COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2VJFW@28216|Betaproteobacteria,4734F@75682|Oxalobacteraceae 28216|Betaproteobacteria H Ketopantoate reductase PanE/ApbA C terminal panE - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_1514986_1 1121447.JONL01000001_gene680 4.72e-78 240.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2WKHW@28221|Deltaproteobacteria,2M8FK@213115|Desulfovibrionales 28221|Deltaproteobacteria Q PFAM ABC transporter related - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_1514986_2 1121451.DESAM_22943 5.46e-07 50.8 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MG3@68525|delta/epsilon subdivisions,2WKC7@28221|Deltaproteobacteria,2M940@213115|Desulfovibrionales 28221|Deltaproteobacteria Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE,STAS_2 k59_1201754_1 1396858.Q666_06855 1.28e-15 72.8 COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,1SD3P@1236|Gammaproteobacteria,467VJ@72275|Alteromonadaceae 1236|Gammaproteobacteria U Preprotein translocase subunit SecG secG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_1201754_2 370438.PTH_2721 2.72e-59 193.0 COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,260CH@186807|Peptococcaceae 186801|Clostridia G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_1619532_1 713586.KB900536_gene147 1.08e-97 291.0 COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,1RPCS@1236|Gammaproteobacteria,1WVX8@135613|Chromatiales 135613|Chromatiales E Belongs to the transferase hexapeptide repeat family dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,THDPS_N_2 k59_52583_1 177439.DP1969 2.19e-45 159.0 COG1206@1|root,COG1206@2|Bacteria,1MWNQ@1224|Proteobacteria,42MTS@68525|delta/epsilon subdivisions,2WJ50@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs trmFO GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 ko:K04094 - - - - ko00000,ko01000,ko03016,ko03036 - - - GIDA k59_418135_1 948071.S4S2D9_9CAUD 3.03e-212 610.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QNQ6@10744|Podoviridae 10744|Podoviridae S ribonucleoside-triphosphate reductase activity - - - - - - - - - - - - - k59_522599_1 479435.Kfla_7018 8.71e-79 260.0 COG2031@1|root,COG2031@2|Bacteria,2HVTQ@201174|Actinobacteria,4DTAA@85009|Propionibacteriales 201174|Actinobacteria I Short chain fatty acid transporter - - - ko:K02106 ko02020,map02020 - - - ko00000,ko00001 2.A.73.1 - - SCFA_trans k59_1567281_1 697282.Mettu_2585 6.22e-104 315.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1XDY2@135618|Methylococcales 135618|Methylococcales H Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - - - - - - - - - - HemN_C,Radical_SAM k59_156909_1 1121363.KB902238_gene985 3.08e-18 86.7 COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria 201174|Actinobacteria C PFAM FAD linked oxidase domain protein - - - - - - - - - - - - BBE,FAD_binding_4 k59_156910_1 1236959.BAMT01000002_gene1921 6.07e-60 193.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,2VH68@28216|Betaproteobacteria,2KKDE@206350|Nitrosomonadales 206350|Nitrosomonadales NU PFAM Pilus assembly protein PilO - - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_466_2 760568.Desku_1141 1.66e-38 145.0 COG0438@1|root,COG1543@1|root,COG0438@2|Bacteria,COG1543@2|Bacteria,1TPFX@1239|Firmicutes,2498V@186801|Clostridia,261CP@186807|Peptococcaceae 186801|Clostridia M Starch synthase catalytic - - 2.4.1.18 ko:K16149 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000 - GH57 - DUF1957,Glyco_hydro_57,Glyco_transf_4,Glycos_transf_1 k59_418144_1 412597.AEPN01000009_gene1788 7.87e-06 51.6 COG4427@1|root,COG4427@2|Bacteria,1R4EV@1224|Proteobacteria,2TRVP@28211|Alphaproteobacteria,2PVMY@265|Paracoccus 28211|Alphaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2332) - - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - DUF2332 k59_418144_2 305900.GV64_19495 5.23e-110 326.0 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,1RRVQ@1236|Gammaproteobacteria,1XPGT@135619|Oceanospirillales 135619|Oceanospirillales IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_731573_1 1454004.AW11_03124 2.62e-05 45.4 COG1392@1|root,COG1392@2|Bacteria,1N4VJ@1224|Proteobacteria 1224|Proteobacteria P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_731573_2 102125.Xen7305DRAFT_00033680 4.58e-76 240.0 COG0306@1|root,COG0306@2|Bacteria 2|Bacteria P phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_1619553_1 177439.DP1202 4.16e-107 325.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2MHX9@213118|Desulfobacterales 28221|Deltaproteobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_418147_1 999423.HMPREF9161_00823 1.04e-80 263.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4H20M@909932|Negativicutes 909932|Negativicutes V lipid A export permease ATP-binding protein MsbA msbA - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_1201791_2 436308.Nmar_0201 5.22e-86 260.0 COG1032@1|root,arCOG01363@2157|Archaea,41S6P@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - - - - - - - - - - - Radical_SAM k59_1515006_1 1408422.JHYF01000014_gene207 6.25e-14 74.7 COG5519@1|root,COG5519@2|Bacteria,1UP6T@1239|Firmicutes,25H7E@186801|Clostridia,36PYG@31979|Clostridiaceae 186801|Clostridia L Bifunctional DNA primase/polymerase, N-terminal - - - - - - - - - - - - Prim-Pol k59_940515_1 2340.JV46_13050 1.84e-55 185.0 COG1014@1|root,COG1144@1|root,COG1014@2|Bacteria,COG1144@2|Bacteria,1N12F@1224|Proteobacteria,1S7UK@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate - - 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR k59_783907_2 316056.RPC_1959 1.77e-30 115.0 COG0310@1|root,COG0310@2|Bacteria,1RJRC@1224|Proteobacteria,2TT2G@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0310 ABC-type Co2 transport system, permease component - - - ko:K02007 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiM k59_470380_1 1245469.S58_62000 6.39e-42 155.0 COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,2TSXR@28211|Alphaproteobacteria,3JUIW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S VWA domain containing CoxE-like protein coxE - - - - - - - - - - - VWA_CoxE k59_940518_1 629773.AORY01000012_gene906 1.45e-09 61.6 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,2TSXW@28211|Alphaproteobacteria,2K1KD@204457|Sphingomonadales 204457|Sphingomonadales G COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_940518_2 1452536.JARE01000055_gene1094 3.55e-08 60.8 COG1052@1|root,COG1052@2|Bacteria,2I3KH@201174|Actinobacteria,4FTEU@85023|Microbacteriaceae 201174|Actinobacteria CH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - 1.1.1.310,1.1.1.399,1.1.1.95 ko:K00058,ko:K16843 ko00260,ko00270,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513,R05693 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_992797_1 290397.Adeh_0685 6.25e-83 269.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2YUKY@29|Myxococcales 28221|Deltaproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_52632_1 1177154.Y5S_02178 3.86e-19 87.8 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RZ5E@1236|Gammaproteobacteria,1XH3B@135619|Oceanospirillales 135619|Oceanospirillales H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_522650_1 338963.Pcar_3064 6.7e-36 137.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,43SX3@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_522650_2 269799.Gmet_3234 1.11e-62 208.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2WJ5V@28221|Deltaproteobacteria,43T66@69541|Desulfuromonadales 28221|Deltaproteobacteria H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_522650_3 1205680.CAKO01000012_gene20 3.91e-11 64.7 COG0007@1|root,COG0007@2|Bacteria,1MUI0@1224|Proteobacteria,2TRJC@28211|Alphaproteobacteria,2JQIR@204441|Rhodospirillales 204441|Rhodospirillales H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_418179_1 298386.PBPRA1404 7.33e-67 217.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1XUVI@135623|Vibrionales 135623|Vibrionales Q COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - - - - - - - - - - DctM k59_209231_1 1001530.BACE01000020_gene3472 8.06e-40 145.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1XTBG@135623|Vibrionales 135623|Vibrionales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU GO:0000270,GO:0000271,GO:0003674,GO:0003824,GO:0003977,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0030203,GO:0033692,GO:0034637,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_209231_2 1184267.A11Q_2182 1e-07 52.4 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2MTXY@213481|Bdellovibrionales,2WRZW@28221|Deltaproteobacteria 213481|Bdellovibrionales O Peptidyl-prolyl cis-trans slyD - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_52633_1 445686.E3SL91_9CAUD 7.11e-29 114.0 4QCGC@10239|Viruses,4QZFA@35237|dsDNA viruses no RNA stage,4QTZH@28883|Caudovirales,4QJ8J@10662|Myoviridae 10662|Myoviridae S Domain of unknown function (DUF4338) - - - - - - - - - - - - - k59_52633_2 444860.E3SJ39_9CAUD 1.33e-33 117.0 4QBC7@10239|Viruses,4QUQW@35237|dsDNA viruses no RNA stage,4QPGT@28883|Caudovirales,4QIH8@10662|Myoviridae 10662|Myoviridae S Pfam:Phage_clamp_A - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_574933_1 324602.Caur_1408 7.55e-13 74.3 COG0147@1|root,COG0147@2|Bacteria,2G5M7@200795|Chloroflexi,374W3@32061|Chloroflexia 32061|Chloroflexia H Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1619590_1 59538.XP_005981260.1 0.000234 42.7 COG0527@1|root,KOG0456@2759|Eukaryota,38QNZ@33154|Opisthokonta,3CNMH@33208|Metazoa,3E4SS@33213|Bilateria 33154|Opisthokonta E ACT domain HOM3 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006531,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009090,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_1619590_2 28229.ND2E_0517 1.23e-24 95.5 COG1551@1|root,COG1551@2|Bacteria,1N6PG@1224|Proteobacteria,1SCB4@1236|Gammaproteobacteria,2Q78E@267889|Colwelliaceae 1236|Gammaproteobacteria J Global regulator protein family csrA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005979,GO:0006109,GO:0006139,GO:0006417,GO:0006446,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0010675,GO:0010677,GO:0010906,GO:0010962,GO:0016070,GO:0016071,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032881,GO:0032885,GO:0034248,GO:0034249,GO:0034641,GO:0043170,GO:0043255,GO:0043467,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045719,GO:0045912,GO:0045947,GO:0046483,GO:0048027,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0062012,GO:0065007,GO:0070873,GO:0070874,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:2000112,GO:2000113 - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k59_104734_1 1177928.TH2_19043 3.26e-109 328.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2JPUA@204441|Rhodospirillales 204441|Rhodospirillales G COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - - - - - - - - - - DctM k59_470410_2 251221.35210680 9.7e-05 43.9 COG2119@1|root,COG2119@2|Bacteria,1G7R2@1117|Cyanobacteria 1117|Cyanobacteria S family UPF0016 - - - - - - - - - - - - UPF0016 k59_627266_1 395493.BegalDRAFT_1882 4.4e-72 221.0 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,460R3@72273|Thiotrichales 72273|Thiotrichales C NADH dehydrogenase nuoE - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_627266_2 523791.Kkor_0294 5.87e-104 312.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1XH7K@135619|Oceanospirillales 135619|Oceanospirillales C NADH-quinone oxidoreductase subunit F - - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_513_1 765913.ThidrDRAFT_1999 9.39e-07 49.7 COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1WWC1@135613|Chromatiales 135613|Chromatiales O TIGRFAM FeS assembly ATPase SufC - - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_1253968_1 349124.Hhal_2016 2.54e-44 149.0 COG0517@1|root,COG0517@2|Bacteria,1N2XI@1224|Proteobacteria,1SA5K@1236|Gammaproteobacteria,1WZKX@135613|Chromatiales 135613|Chromatiales S Domain in cystathionine beta-synthase and other proteins. - - - ko:K07182 - - - - ko00000 - - - CBS k59_1619610_2 663610.JQKO01000001_gene953 2.95e-38 130.0 COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2U95D@28211|Alphaproteobacteria,3NB6F@45404|Beijerinckiaceae 28211|Alphaproteobacteria J structural constituent of ribosome rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_1306201_1 1192124.LIG30_0040 0.000128 43.9 COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2VI8S@28216|Betaproteobacteria,1K0C0@119060|Burkholderiaceae 28216|Betaproteobacteria G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate prpB - 4.1.3.30,5.4.2.9 ko:K01841,ko:K03417 ko00440,ko00640,ko01100,ko01120,ko01130,map00440,map00640,map01100,map01120,map01130 - R00409,R00661 RC00286,RC00287,RC02792 ko00000,ko00001,ko01000 - - - PEP_mutase k59_1306201_2 545264.KB898744_gene2263 2.13e-32 120.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,1WXDT@135613|Chromatiales 135613|Chromatiales J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_1254948_1 671143.DAMO_0812 3.6e-15 77.4 COG0210@1|root,COG0210@2|Bacteria,2NNZG@2323|unclassified Bacteria 2|Bacteria L UvrD/REP helicase N-terminal domain pcrA GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03656,ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_425812_1 1231057.AMGD01000039_gene443 9.73e-15 73.6 COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,4HIR4@91061|Bacilli,26F8J@186818|Planococcaceae 91061|Bacilli MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_269188_1 983545.Glaag_4522 2.46e-95 305.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,464J4@72275|Alteromonadaceae 1236|Gammaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cusA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_269188_2 1117315.AHCA01000007_gene3735 1.72e-33 132.0 COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria,2PZP9@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cusB - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - CusF_Ec,HlyD_D23,HlyD_D4 k59_896120_1 765914.ThisiDRAFT_2315 2.38e-142 441.0 COG0187@1|root,COG1372@1|root,COG0187@2|Bacteria,COG1372@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_269195_1 435908.IDSA_09160 6.91e-70 225.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,2QF9V@267893|Idiomarinaceae 1236|Gammaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_1052753_1 56780.SYN_00640 1.59e-38 143.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2MQ50@213462|Syntrophobacterales 28221|Deltaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_738983_1 504472.Slin_5458 6.05e-42 145.0 COG1285@1|root,COG1285@2|Bacteria,4NRHK@976|Bacteroidetes,47MUD@768503|Cytophagia 976|Bacteroidetes S PFAM MgtC SapB transporter - - - ko:K07507 - - - - ko00000,ko02000 9.B.20 - - MgtC k59_373552_1 1122185.N792_02830 3.86e-38 143.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1X3IX@135614|Xanthomonadales 135614|Xanthomonadales C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_1052761_1 243233.MCA2375 4.15e-111 340.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1XDNZ@135618|Methylococcales 135618|Methylococcales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1627220_1 411902.CLOBOL_06263 9.95e-21 95.1 COG1215@1|root,COG3222@1|root,COG1215@2|Bacteria,COG3222@2|Bacteria,1UFV7@1239|Firmicutes,24BR5@186801|Clostridia,21YEW@1506553|Lachnoclostridium 186801|Clostridia M Uncharacterized protein conserved in bacteria (DUF2064) - - - - - - - - - - - - DUF2064,Glycos_transf_2 k59_3944_2 314278.NB231_10393 8.62e-17 80.1 COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,1RNFJ@1236|Gammaproteobacteria,1WWXB@135613|Chromatiales 135613|Chromatiales T PFAM PrkA AAA - - - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_62306_1 706587.Desti_3287 6.42e-73 225.0 COG4977@1|root,COG4977@2|Bacteria,1QUTN@1224|Proteobacteria,43CIK@68525|delta/epsilon subdivisions 1224|Proteobacteria K DJ-1/PfpI family inhA - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_1366051_1 243365.CV_2342 4.82e-12 65.1 COG1435@1|root,COG1435@2|Bacteria,1NJR4@1224|Proteobacteria 1224|Proteobacteria F thymidine kinase tdk GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 ko:K00857 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01567,R02099,R08233 RC00002,RC00017 ko00000,ko00001,ko01000 - - iAF1260.b1238,iBWG_1329.BWG_1065,iECDH10B_1368.ECDH10B_1298,iECDH1ME8569_1439.ECDH1ME8569_1176,iEcDH1_1363.EcDH1_2411,iJO1366.b1238,iJR904.b1238,iPC815.YPO2176,iY75_1357.Y75_RS06470 TK k59_738994_1 330214.NIDE3255 4.22e-57 196.0 COG0243@1|root,COG0243@2|Bacteria 2|Bacteria C molybdopterin cofactor binding ddhA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4 ko:K00370,ko:K10700,ko:K16964,ko:K17050 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_1627231_1 765914.ThisiDRAFT_0521 6.91e-106 325.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria,1WX2Y@135613|Chromatiales 135613|Chromatiales I synthetase - - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_999571_1 861299.J421_3812 3.18e-159 471.0 COG0296@1|root,COG0296@2|Bacteria,1ZT8Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_1366057_1 330214.NIDE0158 1.27e-98 305.0 COG1032@1|root,COG1032@2|Bacteria 2|Bacteria C radical SAM domain protein - - - - - - - - - - - - B12-binding,Radical_SAM k59_1313550_1 243231.GSU2081 3.41e-15 79.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,42S9I@68525|delta/epsilon subdivisions,2WNTW@28221|Deltaproteobacteria,43TCT@69541|Desulfuromonadales 28221|Deltaproteobacteria D Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_636875_1 543913.D521_1206 1.15e-36 132.0 COG3449@1|root,COG3449@2|Bacteria,1RF2U@1224|Proteobacteria,2VST9@28216|Betaproteobacteria,1KR16@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria L SOUL heme-binding protein - - - - - - - - - - - - SOUL k59_1520149_1 998674.ATTE01000001_gene506 1.83e-51 180.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,45ZZX@72273|Thiotrichales 72273|Thiotrichales T response regulator receiver - - - - - - - - - - - - DUF229,HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat k59_216831_1 472759.Nhal_2667 2.1e-15 75.5 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1WVW1@135613|Chromatiales 135613|Chromatiales C 4Fe-4S ferredoxin iron-sulfur binding domain protein glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7,Fer4_8 k59_216831_2 562970.Btus_1004 1.04e-111 339.0 COG2225@1|root,COG2225@2|Bacteria,1TPE8@1239|Firmicutes,4H9ST@91061|Bacilli,27820@186823|Alicyclobacillaceae 91061|Bacilli C Belongs to the malate synthase family aceB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_477940_2 349124.Hhal_0305 2.74e-39 139.0 COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,1RRR0@1236|Gammaproteobacteria,1WY0S@135613|Chromatiales 135613|Chromatiales O PFAM 20S proteasome, A and B subunits - - - ko:K07395 - - - - ko00000 - - - Proteasome k59_1156940_1 1117647.M5M_04610 3.18e-30 115.0 COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria,1J4YC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U COG0811 Biopolymer transport proteins - - - - - - - - - - - - MotA_ExbB k59_582309_1 1177181.T9A_03054 1.68e-44 160.0 COG2067@1|root,COG2067@2|Bacteria,1PXPC@1224|Proteobacteria,1RQKS@1236|Gammaproteobacteria,1XHI3@135619|Oceanospirillales 135619|Oceanospirillales I Protein of unknown function (DUF3570) - - - - - - - - - - - - DUF3570 k59_688801_1 585423.KR49_00935 3.15e-11 65.9 COG1028@1|root,COG1028@2|Bacteria,1GPZC@1117|Cyanobacteria,1GZ3F@1129|Synechococcus 1117|Cyanobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short k59_62332_1 330214.NIDE1421 2.54e-100 305.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,3J0A1@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_321957_1 483219.LILAB_06115 3.08e-72 232.0 COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,437V8@68525|delta/epsilon subdivisions,2X34Q@28221|Deltaproteobacteria,2YU9A@29|Myxococcales 28221|Deltaproteobacteria E Peptidase dimerisation domain dapE1 - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_1156948_1 187272.Mlg_0003 9.42e-29 116.0 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria,1WYPF@135613|Chromatiales 135613|Chromatiales L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - AAA_23,SMC_N k59_162556_1 1397666.RS24_01745 2.54e-78 263.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,4BPHH@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_843763_1 1049564.TevJSym_ab02100 4.77e-84 263.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1J4CY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_62341_1 192875.XP_004342748.1 1.64e-43 160.0 COG0621@1|root,KOG2492@2759|Eukaryota,38E0X@33154|Opisthokonta 33154|Opisthokonta T N6-isopentenyladenosine methylthiotransferase activity CDK5RAP1 GO:0000079,GO:0000959,GO:0000963,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006450,GO:0006469,GO:0006725,GO:0006807,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0008033,GO:0008150,GO:0008152,GO:0008283,GO:0009451,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010563,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0016070,GO:0016740,GO:0016782,GO:0019207,GO:0019220,GO:0019222,GO:0019887,GO:0019899,GO:0019900,GO:0019901,GO:0022008,GO:0030154,GO:0030234,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0032270,GO:0032501,GO:0032502,GO:0033673,GO:0034248,GO:0034250,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0042325,GO:0042326,GO:0043086,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043549,GO:0044092,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045595,GO:0045664,GO:0045727,GO:0045736,GO:0045786,GO:0045859,GO:0045903,GO:0045936,GO:0046483,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050497,GO:0050767,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051239,GO:0051246,GO:0051247,GO:0051248,GO:0051338,GO:0051348,GO:0051726,GO:0051960,GO:0060255,GO:0060284,GO:0060322,GO:0065007,GO:0065008,GO:0065009,GO:0070129,GO:0070131,GO:0070525,GO:0070900,GO:0071704,GO:0071900,GO:0071901,GO:0080090,GO:0090304,GO:0090646,GO:0098772,GO:0140053,GO:1900864,GO:1901360,GO:1904029,GO:1904030,GO:2000026,GO:2000112 - - - - - - - - - - Radical_SAM,TRAM,UPF0004 k59_688806_1 237368.SCABRO_03057 7.69e-56 194.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_trans_1_4,Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1 k59_688806_2 1173028.ANKO01000018_gene1193 4.35e-07 50.1 COG0153@1|root,COG0153@2|Bacteria,1G2KU@1117|Cyanobacteria,1HA2U@1150|Oscillatoriales 1117|Cyanobacteria H GHMP kinases N terminal domain - - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_N k59_3953_1 1286106.MPL1_10677 5.54e-23 100.0 COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria,460N9@72273|Thiotrichales 72273|Thiotrichales NU TIGRFAM type IV pilus biogenesis stability protein PilW - - - ko:K02656 - - - - ko00000,ko02035,ko02044 - - - TPR_2,TPR_8 k59_1627259_1 436308.Nmar_0714 6.91e-44 157.0 arCOG00373@1|root,arCOG00373@2157|Archaea,41ST8@651137|Thaumarchaeota 651137|Thaumarchaeota L ATPase involved in DNA repair - - - - - - - - - - - - - k59_62346_1 1391646.AVSU01000038_gene1952 9.27e-46 169.0 COG2978@1|root,COG2978@2|Bacteria,1TPDU@1239|Firmicutes,24BJ1@186801|Clostridia 186801|Clostridia H Transporter - - - ko:K12942 - - - - ko00000 - - - ABG_transport k59_477946_1 1122194.AUHU01000004_gene1633 6.44e-164 469.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,464AG@72275|Alteromonadaceae 1236|Gammaproteobacteria C CoA-transferase family III frc - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_477946_2 1218084.BBJK01000037_gene3499 6.01e-35 135.0 COG2084@1|root,COG2084@2|Bacteria,1MWR4@1224|Proteobacteria,2W0FJ@28216|Betaproteobacteria,1KFFZ@119060|Burkholderiaceae 28216|Betaproteobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_794412_1 364733.XP_007803056.1 1.76e-09 63.5 COG0451@1|root,KOG1430@2759|Eukaryota,39T9W@33154|Opisthokonta,3NX92@4751|Fungi,3QPYR@4890|Ascomycota,20TIK@147545|Eurotiomycetes,3MY3Y@451870|Chaetothyriomycetidae 4751|Fungi EI RmlD substrate binding domain - - 1.1.1.170 ko:K07748 ko00100,ko01100,ko01130,map00100,map01100,map01130 M00101 R07494 RC01163 ko00000,ko00001,ko00002,ko01000 - - - 3Beta_HSD k59_637652_1 1449353.JQMQ01000005_gene1873 2.69e-17 77.8 COG3467@1|root,COG3467@2|Bacteria,2IQIK@201174|Actinobacteria,2NMQ7@228398|Streptacidiphilus 201174|Actinobacteria S Pfam:Pyridox_oxidase - - - - - - - - - - - - Putative_PNPOx k59_637652_2 1469245.JFBG01000102_gene1324 7.39e-27 106.0 COG2141@1|root,COG2141@2|Bacteria,1PGW7@1224|Proteobacteria,1SWMS@1236|Gammaproteobacteria,1X1KD@135613|Chromatiales 135613|Chromatiales C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_689401_1 472759.Nhal_0363 7.02e-06 48.5 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1X28I@135613|Chromatiales 135613|Chromatiales M Lysin motif - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_844348_1 1185876.BN8_00780 2.43e-22 105.0 COG0477@1|root,COG2814@2|Bacteria,4NFM7@976|Bacteroidetes,47N08@768503|Cytophagia 976|Bacteroidetes EGP Major facilitator superfamily - - - ko:K08151 - M00668 - - ko00000,ko00002,ko01504,ko02000 2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75 - - MFS_1,Sugar_tr k59_163150_1 765912.Thimo_1643 1.96e-51 168.0 COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,1S2XX@1236|Gammaproteobacteria,1WY2K@135613|Chromatiales 135613|Chromatiales S TIGRFAM Polyhydroxyalkanoate synthesis repressor PhaR - - - - - - - - - - - - PHB_acc,PHB_acc_N k59_163150_2 688269.Theth_1253 8.21e-12 67.0 COG4177@1|root,COG4177@2|Bacteria,2GC2F@200918|Thermotogae 200918|Thermotogae EI Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Abhydrolase_1,BPD_transp_2 k59_217462_1 331869.BAL199_16713 8.3e-33 117.0 COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,2UBXS@28211|Alphaproteobacteria,4BQHC@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C 4TM region of pyridine nucleotide transhydrogenase, mitoch pntAB GO:0008150,GO:0008152,GO:0055114 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB_4TM k59_217462_2 768671.ThimaDRAFT_4071 2.71e-17 81.6 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1WW1T@135613|Chromatiales 135613|Chromatiales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane - - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_163153_1 864702.OsccyDRAFT_4524 2.31e-57 185.0 COG1898@1|root,COG1898@2|Bacteria,1G0QA@1117|Cyanobacteria,1H6ZK@1150|Oscillatoriales 1117|Cyanobacteria M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_426458_1 1249627.D779_3855 1.28e-106 332.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1WW89@135613|Chromatiales 135613|Chromatiales V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_269824_1 316067.Geob_1974 6.72e-112 345.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,43UGC@69541|Desulfuromonadales 28221|Deltaproteobacteria L PFAM UvrD REP helicase rep - 3.6.4.12 ko:K03656,ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1366690_1 1298863.AUEP01000001_gene879 1.25e-65 224.0 COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4DN7Q@85009|Propionibacteriales 201174|Actinobacteria C 2-oxoglutarate dehydrogenase kgd GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 ko:K00164,ko:K01616 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv1248c 2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_794451_1 477641.MODMU_3610 8.34e-17 77.4 COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria,4ETAR@85013|Frankiales 201174|Actinobacteria P PFAM Rieske 2Fe-2S sufE - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske k59_794451_2 381666.H16_B1516 1.96e-38 133.0 COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,2VQ3A@28216|Betaproteobacteria,1K7JP@119060|Burkholderiaceae 28216|Betaproteobacteria C NifU-like N terminal domain - - - ko:K04488 - - - - ko00000 - - - NifU_N k59_269842_1 883.DvMF_2572 1.04e-28 120.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P8Q@68525|delta/epsilon subdivisions,2WK2B@28221|Deltaproteobacteria,2MABU@213115|Desulfovibrionales 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K11384 ko02020,map02020 M00505 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1000292_1 1089552.KI911559_gene2809 2.48e-28 113.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2TRD9@28211|Alphaproteobacteria,2JPC9@204441|Rhodospirillales 204441|Rhodospirillales J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_63140_2 384765.SIAM614_06578 1.08e-44 152.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2U6EM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_63140_3 584708.Apau_1863 5.96e-13 70.1 COG4907@1|root,COG4907@2|Bacteria,3TA8F@508458|Synergistetes 508458|Synergistetes S membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_1520596_1 1449049.JONW01000006_gene3277 8.21e-30 111.0 COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,2UDEK@28211|Alphaproteobacteria,2KGZA@204458|Caulobacterales 204458|Caulobacterales S PFAM Membrane protein of - - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 k59_948182_1 1121422.AUMW01000027_gene446 1.53e-50 169.0 COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,260TX@186807|Peptococcaceae 186801|Clostridia S (AIR) carboxylase - - - ko:K06898 - - - - ko00000 - - - AIRC k59_478729_1 1385515.N791_06585 3.16e-12 66.6 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,1X3M9@135614|Xanthomonadales 135614|Xanthomonadales P Transporter corC - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_478729_2 1537994.JQFW01000027_gene2101 4.81e-32 117.0 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,1S6BS@1236|Gammaproteobacteria,467I5@72275|Alteromonadaceae 1236|Gammaproteobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_637709_1 861299.J421_3401 3.25e-103 321.0 COG1185@1|root,COG1185@2|Bacteria,1ZT7C@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_1053409_1 1125973.JNLC01000015_gene3397 6.2e-233 652.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2TRVF@28211|Alphaproteobacteria,3K2QU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H AMP-binding enzyme C-terminal domain - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_1053409_2 1444309.JAQG01000100_gene4694 2.89e-09 58.5 COG0346@1|root,COG2185@1|root,COG0346@2|Bacteria,COG2185@2|Bacteria,1V5GM@1239|Firmicutes,4HH66@91061|Bacilli,26S25@186822|Paenibacillaceae 91061|Bacilli E Lactoylglutathione lyase - - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 k59_637710_1 511062.GU3_07285 5.16e-103 325.0 COG0532@1|root,COG3064@1|root,COG0532@2|Bacteria,COG3064@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1Y3FR@135624|Aeromonadales 135624|Aeromonadales J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N,IF2_assoc k59_112346_1 1528106.JRJE01000006_gene990 4.98e-20 81.6 2EGMT@1|root,33ADY@2|Bacteria,1NH3I@1224|Proteobacteria,2UFRY@28211|Alphaproteobacteria,2JUKX@204441|Rhodospirillales 204441|Rhodospirillales S Phospholipase_D-nuclease N-terminal - - - - - - - - - - - - PLDc_N k59_1366723_1 1122135.KB893134_gene3141 1.3e-11 65.1 COG0697@1|root,COG0697@2|Bacteria,1N47T@1224|Proteobacteria,2UE3C@28211|Alphaproteobacteria 28211|Alphaproteobacteria EG spore germination - - - - - - - - - - - - EamA k59_1366723_2 596154.Alide2_1986 1.34e-42 149.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2VMN7@28216|Betaproteobacteria,4ACKI@80864|Comamonadaceae 28216|Betaproteobacteria C D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding ptxD - 1.20.1.1 ko:K18916 - - - - ko00000,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_380553_1 990285.RGCCGE502_19740 0.000179 43.1 COG3960@1|root,COG3960@2|Bacteria,1MV88@1224|Proteobacteria,2TQTW@28211|Alphaproteobacteria,4BC8D@82115|Rhizobiaceae 28211|Alphaproteobacteria S Thiamine pyrophosphate enzyme, central domain gcl - 4.1.1.47 ko:K01608 ko00630,ko01100,map00630,map01100 - R00013 RC00899 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_380553_2 1121939.L861_12775 9.22e-59 192.0 COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,1RY9N@1236|Gammaproteobacteria,1XKZ2@135619|Oceanospirillales 135619|Oceanospirillales K IclR family transcriptional regulator - - - ko:K02624,ko:K13641,ko:K20539 ko02024,map02024 - - - ko00000,ko00001,ko03000 - - - HTH_IclR,IclR k59_486047_1 754476.Q7A_1529 9.31e-46 167.0 COG4774@1|root,COG4774@2|Bacteria,1QW60@1224|Proteobacteria,1T58A@1236|Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_801932_1 330214.NIDE0568 1.35e-85 276.0 COG0178@1|root,COG0178@2|Bacteria,3J0C7@40117|Nitrospirae 40117|Nitrospirae L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1161903_1 472759.Nhal_2258 9.83e-66 217.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1WX2Q@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_3,HlyD_D23,OEP k59_1524160_1 1123257.AUFV01000003_gene1268 3.16e-70 219.0 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1S3J8@1236|Gammaproteobacteria,1XC9E@135614|Xanthomonadales 135614|Xanthomonadales S Predicted membrane protein (DUF2238) - - - - - - - - - - - - DUF2238 k59_801946_1 452662.SJA_C2-04050 4.33e-76 242.0 COG0318@1|root,COG0318@2|Bacteria,1MUIC@1224|Proteobacteria,2TUFX@28211|Alphaproteobacteria,2K8FT@204457|Sphingomonadales 204457|Sphingomonadales IQ AMP-binding enzyme C-terminal domain - - 6.2.1.7 ko:K15868 ko00121,map00121 - - - ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_1217630_1 420662.Mpe_A3264 4.06e-99 304.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2VKR6@28216|Betaproteobacteria,1KIXT@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Formate--tetrahydrofolate ligase fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_694872_1 289376.THEYE_A1628 1.92e-31 124.0 COG1566@1|root,COG1566@2|Bacteria,3J0TB@40117|Nitrospirae 40117|Nitrospirae V HlyD family secretion protein - - - ko:K01993 - - - - ko00000 - - - HlyD_D23 k59_1372044_1 1122201.AUAZ01000015_gene737 8.31e-15 72.0 COG2050@1|root,COG2050@2|Bacteria,1QU0P@1224|Proteobacteria,1T1K4@1236|Gammaproteobacteria,465I3@72275|Alteromonadaceae 1236|Gammaproteobacteria Q COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1,YiiD_C k59_1372044_2 349521.HCH_02825 1.6e-65 202.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,1S5BM@1236|Gammaproteobacteria,1XJQ6@135619|Oceanospirillales 135619|Oceanospirillales S Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_694875_1 926550.CLDAP_05650 2.44e-74 234.0 COG0673@1|root,COG0673@2|Bacteria,2G5MT@200795|Chloroflexi 200795|Chloroflexi S PFAM oxidoreductase domain protein - - - - - - - - - - - - GFO_IDH_MocA k59_327974_1 1121106.JQKB01000007_gene1121 2.97e-132 386.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2TSHT@28211|Alphaproteobacteria,2JPS4@204441|Rhodospirillales 204441|Rhodospirillales EH Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_1426021_1 518766.Rmar_2595 5.32e-112 333.0 COG0409@1|root,COG0409@2|Bacteria,4NIM8@976|Bacteroidetes 976|Bacteroidetes O TIGRFAM hydrogenase expression formation protein HypD - - - ko:K04654 - - - - ko00000 - - - HypD k59_588444_1 1207076.ALAT01000160_gene3260 3.05e-77 256.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1Z1AB@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1633741_2 1288494.EBAPG3_24630 2.37e-28 113.0 COG1763@1|root,COG1763@2|Bacteria,1QUQC@1224|Proteobacteria,2WBV7@28216|Betaproteobacteria,373V7@32003|Nitrosomonadales 28216|Betaproteobacteria H Mo-molybdopterin cofactor biosynthetic process - - - - - - - - - - - - - k59_1058899_1 292564.Cyagr_2374 8.91e-12 62.4 COG5485@1|root,COG5485@2|Bacteria 2|Bacteria S SnoaL-like polyketide cyclase - - 3.1.1.45 ko:K01061,ko:K15945 ko00361,ko00364,ko00623,ko01057,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01057,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222,R09330 RC00046,RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - SnoaL,SnoaL_2 k59_1058899_2 1211115.ALIQ01000018_gene2157 2.26e-150 440.0 COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1QWNC@1224|Proteobacteria,2TRQB@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) - - - - - - - - - - - - GAF,Guanylate_cyc k59_1058899_3 744980.TRICHSKD4_0843 1.58e-22 93.6 COG0824@1|root,COG0824@2|Bacteria,1MZFI@1224|Proteobacteria,2U5Q6@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Thioesterase MA20_08165 - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2,Acyl-ACP_TE k59_1058899_4 1236902.ANAS01000001_gene1831 8.43e-11 64.7 COG0447@1|root,COG0447@2|Bacteria,2GK5G@201174|Actinobacteria,4EI6I@85012|Streptosporangiales 201174|Actinobacteria H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) menB - 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1634743_1 1249627.D779_2227 1.26e-86 269.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1WX7U@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_328782_1 338966.Ppro_0673 5.97e-51 183.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,43T41@69541|Desulfuromonadales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_589220_1 1192034.CAP_2777 4.59e-107 338.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,42M5P@68525|delta/epsilon subdivisions,2WIW8@28221|Deltaproteobacteria,2YUB7@29|Myxococcales 28221|Deltaproteobacteria KL Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_1480657_1 55529.EKX49309 1.12e-54 182.0 COG0293@1|root,KOG1098@2759|Eukaryota 2759|Eukaryota J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily - - - ko:K14857 - - - - ko00000,ko01000,ko03009 - - - DUF3381,FtsJ,Spb1_C k59_1480657_2 472759.Nhal_3706 2.43e-143 424.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1WX7K@135613|Chromatiales 135613|Chromatiales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_223743_2 713586.KB900536_gene1089 9.34e-56 183.0 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1WW30@135613|Chromatiales 135613|Chromatiales S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - ko:K11206 - - - - ko00000,ko01000 - - - CN_hydrolase k59_850508_2 2340.JV46_08040 1.42e-93 279.0 COG0678@1|root,COG0695@1|root,COG0678@2|Bacteria,COG0695@2|Bacteria,1MU0H@1224|Proteobacteria,1RRFB@1236|Gammaproteobacteria,1J5WI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0678 Peroxiredoxin VY92_02980 - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - Glutaredoxin,Redoxin k59_328788_2 745014.OMB55_00022730 2.47e-50 175.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria 1236|Gammaproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_1272681_1 330214.NIDE0232 5.65e-29 114.0 COG3383@1|root,COG3383@2|Bacteria,3J0UR@40117|Nitrospirae 2|Bacteria C Molydopterin dinucleotide binding domain hcnA - 1.4.99.5,1.5.3.1 ko:K00302,ko:K10814 ko00260,ko00460,ko01100,ko01110,map00260,map00460,map01100,map01110 - R00374,R00610,R05704 RC00060,RC00557,RC02808 ko00000,ko00001,ko01000,ko02042 - - - Fer2_4 k59_1272681_2 330214.NIDE0233 3.86e-114 337.0 COG0649@1|root,COG0649@2|Bacteria,3J0FM@40117|Nitrospirae 40117|Nitrospirae C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa,NiFeSe_Hases k59_223747_1 1278078.G419_21015 9.9e-14 77.4 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4G08Q@85025|Nocardiaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_169403_1 1122611.KB903969_gene2413 4.01e-09 57.8 COG5361@1|root,COG5361@2|Bacteria,2HES3@201174|Actinobacteria,4EPZM@85012|Streptosporangiales 201174|Actinobacteria S Conserved Protein - - - - - - - - - - - - DUF1214 k59_169403_2 1112204.GPOL_c47830 2.54e-17 83.6 COG0438@1|root,COG0438@2|Bacteria,2I7GS@201174|Actinobacteria,4GG64@85026|Gordoniaceae 201174|Actinobacteria M Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3 k59_1427036_1 330214.NIDE1304 1.42e-105 337.0 COG0086@1|root,COG0086@2|Bacteria,3J0BT@40117|Nitrospirae 40117|Nitrospirae K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_119427_1 1210884.HG799465_gene11731 1.11e-05 47.4 COG1393@1|root,COG1393@2|Bacteria,2J19I@203682|Planctomycetes 203682|Planctomycetes P Belongs to the ArsC family - - - - - - - - - - - - - k59_119427_2 1123072.AUDH01000011_gene3606 1.45e-73 243.0 COG1574@1|root,COG1574@2|Bacteria,1R53N@1224|Proteobacteria,2VF84@28211|Alphaproteobacteria,2JYNZ@204441|Rhodospirillales 204441|Rhodospirillales S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_432575_1 1229909.NSED_06255 3.46e-100 298.0 COG0473@1|root,arCOG01163@2157|Archaea,41SAA@651137|Thaumarchaeota 651137|Thaumarchaeota C Isocitrate isopropylmalate dehydrogenase - - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_695708_1 243233.MCA0468 1.22e-74 233.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria,1XE09@135618|Methylococcales 135618|Methylococcales S associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_381656_1 330214.NIDE2086 4.16e-22 96.3 COG1074@1|root,COG1074@2|Bacteria,3J16M@40117|Nitrospirae 40117|Nitrospirae L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_745837_1 1163617.SCD_n00308 3.58e-42 157.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2VICZ@28216|Betaproteobacteria 28216|Betaproteobacteria M Lipid A Biosynthesis htrB - 2.3.1.241,2.3.1.242 ko:K02517,ko:K12974 ko00540,ko01100,map00540,map01100 M00060 R05146,R10906 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_645954_1 1216966.BAUC01000012_gene232 1.42e-33 125.0 COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,1RQ3P@1236|Gammaproteobacteria 1236|Gammaproteobacteria GK ROK family mak GO:0003674,GO:0003824,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704 2.7.1.2,2.7.1.4 ko:K00845,ko:K00847 ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R00760,R00867,R01600,R01786,R03920 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iECSE_1348.ECSE_0415,iEcHS_1320.EcHS_A0462,iPC815.YPO3211,iS_1188.S0338,iYL1228.KPN_00337 ROK k59_1162625_1 1379270.AUXF01000004_gene3004 1.19e-10 63.9 COG2805@1|root,COG2805@2|Bacteria,1ZT2Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1162625_2 926554.KI912633_gene3824 1.46e-23 92.4 COG3360@1|root,COG3360@2|Bacteria,1WKKK@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Dodecin - - - ko:K09165 - - - - ko00000 - - - Dodecin k59_1162625_3 1123377.AUIV01000008_gene1394 4.75e-46 160.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1X3HE@135614|Xanthomonadales 135614|Xanthomonadales T Phosphate starvation protein PhoH - - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_1111964_1 1303518.CCALI_02908 3.06e-44 158.0 COG4102@1|root,COG4102@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_276191_1 522306.CAP2UW1_3606 1.98e-67 218.0 COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,1KPWM@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Coenzyme metabolism Energy production and conversion ascD - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_381682_1 1288826.MSNKSG1_18220 4.22e-52 168.0 COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria,4672S@72275|Alteromonadaceae 1236|Gammaproteobacteria L Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010468,GO:0010604,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0033554,GO:0034353,GO:0034641,GO:0034655,GO:0043167,GO:0043169,GO:0043170,GO:0043487,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0045935,GO:0046483,GO:0046700,GO:0046872,GO:0048518,GO:0048519,GO:0048522,GO:0050779,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:1901360,GO:1901361,GO:1901575 - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX k59_381682_2 1116472.MGMO_59c00100 6.86e-13 66.2 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1XEB3@135618|Methylococcales 135618|Methylococcales E subfamily IB - - - - - - - - - - - - HAD k59_695732_1 1131553.JIBI01000027_gene2401 3.62e-106 314.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2VIVB@28216|Betaproteobacteria,372AH@32003|Nitrosomonadales 28216|Betaproteobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_695736_2 471223.GWCH70_1062 1.19e-13 70.5 COG0242@1|root,COG0242@2|Bacteria,1V70B@1239|Firmicutes,4HHMA@91061|Bacilli,1WFPQ@129337|Geobacillus 91061|Bacilli J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008463,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_487181_1 76869.PputGB1_0188 3.57e-73 231.0 COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,1RZ34@1236|Gammaproteobacteria,1YXF0@136845|Pseudomonas putida group 1236|Gammaproteobacteria Q PFAM Taurine catabolism dioxygenase TauD TfdA tauD - 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_487181_2 640081.Dsui_0638 3.07e-48 160.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2VHIC@28216|Betaproteobacteria,2KUY5@206389|Rhodocyclales 206389|Rhodocyclales E ABC-type polar amino acid transport system, ATPase component - - - ko:K10004 ko02010,ko02020,map02010,map02020 M00230 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3.19,3.A.1.3.4 - - ABC_tran k59_903019_1 1395571.TMS3_0118140 2.84e-42 147.0 COG2188@1|root,COG2188@2|Bacteria,1MVFM@1224|Proteobacteria,1RNPE@1236|Gammaproteobacteria 1236|Gammaproteobacteria K histidine utilization repressor hutC - - ko:K05836 - - - - ko00000,ko03000 - - - GntR,UTRA k59_1162648_1 1384054.N790_11570 8.49e-05 50.1 COG2374@1|root,COG2931@1|root,COG2374@2|Bacteria,COG2931@2|Bacteria,1MX52@1224|Proteobacteria,1RRGN@1236|Gammaproteobacteria,1X3H2@135614|Xanthomonadales 135614|Xanthomonadales Q Lamin Tail Domain nucH - - ko:K07004 - - - - ko00000 - - - Calx-beta,Exo_endo_phos,LTD k59_954615_1 1265310.CCBD010000023_gene4280 6.45e-35 129.0 28K5H@1|root,2Z9U4@2|Bacteria,2GKEQ@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1581392_1 1328313.DS2_13984 3e-05 52.4 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,465DD@72275|Alteromonadaceae 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_536891_1 222534.KB893739_gene1423 5.81e-16 80.1 COG0373@1|root,COG0373@2|Bacteria,2GJRA@201174|Actinobacteria,4ERHS@85013|Frankiales 201174|Actinobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA GO:0008150,GO:0040007 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_536891_2 1121403.AUCV01000034_gene3841 1.32e-14 74.7 COG0755@1|root,COG0755@2|Bacteria,1RCCI@1224|Proteobacteria,42PVM@68525|delta/epsilon subdivisions,2WJ7I@28221|Deltaproteobacteria,2MHT7@213118|Desulfobacterales 28221|Deltaproteobacteria O Cytochrome c assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_646009_1 1123023.JIAI01000002_gene4645 4.59e-97 291.0 COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_432643_1 388401.RB2150_17857 1.72e-23 95.9 COG3473@1|root,COG3473@2|Bacteria,1PMDH@1224|Proteobacteria,2VA3Y@28211|Alphaproteobacteria,3ZIAY@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria Q COG3473 Maleate cis-trans isomerase - - - - - - - - - - - - - k59_432643_2 1187851.A33M_3793 8.86e-72 231.0 COG1893@1|root,COG1893@2|Bacteria,1PHTA@1224|Proteobacteria,2V7UU@28211|Alphaproteobacteria,3FEG1@34008|Rhodovulum 28211|Alphaproteobacteria H Ketopantoate reductase PanE/ApbA C terminal - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_536892_1 1122919.KB905576_gene3373 3.6e-08 60.1 COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,4HCST@91061|Bacilli,26SMB@186822|Paenibacillaceae 91061|Bacilli T Sigma-54 interaction domain - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_954624_1 257310.BB3550 1.3e-18 90.9 COG0318@1|root,COG0318@2|Bacteria,1MWSD@1224|Proteobacteria,2VR64@28216|Betaproteobacteria 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.48 ko:K02182 - - - - ko00000,ko01000 - - - AMP-binding,AMP-binding_C k59_381729_1 68570.DC74_8142 2.78e-73 238.0 COG1053@1|root,COG1053@2|Bacteria,2GKS3@201174|Actinobacteria 201174|Actinobacteria C succinate dehydrogenase fumarate reductase, flavoprotein subunit - - 1.3.99.5 ko:K16051 ko00984,ko01120,map00984,map01120 - R01834 RC00145 ko00000,ko00001,ko01000 - - - FAD_binding_2 k59_541449_1 1123360.thalar_02885 1.5e-89 280.0 COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2U068@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome C and Quinol oxidase polypeptide I - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_1488110_1 331869.BAL199_21649 2.34e-127 372.0 COG2084@1|root,COG2084@2|Bacteria,1PU4S@1224|Proteobacteria,2TT0X@28211|Alphaproteobacteria,4BPJG@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_173928_1 436308.Nmar_1245 6.96e-102 316.0 COG0419@1|root,COG1122@1|root,arCOG00202@2157|Archaea,arCOG00368@2157|Archaea,41S9P@651137|Thaumarchaeota 651137|Thaumarchaeota LP AAA domain - - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_15 k59_173928_2 1229909.NSED_07010 1.47e-35 132.0 COG3794@1|root,arCOG10350@1|root,arCOG02926@2157|Archaea,arCOG10350@2157|Archaea 2157|Archaea C sister chromatid segregation - - - - - - - - - - - - Copper-bind,Kazal_1 k59_1012621_1 1122222.AXWR01000001_gene1872 2.57e-49 169.0 COG0457@1|root,COG0457@2|Bacteria,1WKXF@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Peptidase_C39 like family - - - - - - - - - - - - Peptidase_C39_2,TPR_2,TPR_8 k59_281923_1 395493.BegalDRAFT_2551 1.42e-55 189.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,45ZVD@72273|Thiotrichales 72273|Thiotrichales E TIGRFAM Acetolactate synthase, large subunit, biosynthetic - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_281923_2 580332.Slit_2403 1.35e-66 206.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2VH1H@28216|Betaproteobacteria,44VPP@713636|Nitrosomonadales 28216|Betaproteobacteria E ACT domain ilvH GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT_5,ALS_ss_C k59_1488123_1 1299327.I546_2826 4.59e-131 383.0 COG2124@1|root,COG2124@2|Bacteria,2GKKN@201174|Actinobacteria,23477@1762|Mycobacteriaceae 201174|Actinobacteria Q cytochrome p450 - - 1.14.15.13 ko:K17474 - - - - ko00000,ko00199,ko01000 - - - p450 k59_1280529_2 998674.ATTE01000001_gene4168 1.5e-27 111.0 COG1196@1|root,COG1196@2|Bacteria,1MVMQ@1224|Proteobacteria,1S2MH@1236|Gammaproteobacteria 1236|Gammaproteobacteria D nuclear chromosome segregation - - - - - - - - - - - - - k59_126189_1 1410628.JNKS01000022_gene670 2.48e-13 74.7 COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,1TT1J@1239|Firmicutes,24BC2@186801|Clostridia,27J8G@186928|unclassified Lachnospiraceae 186801|Clostridia N ABC-type uncharacterized transport system - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3,ABC_transp_aux k59_334382_1 1380390.JIAT01000009_gene1779 1.48e-57 195.0 COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4CQ6E@84995|Rubrobacteria 84995|Rubrobacteria T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_810595_2 247634.GPB2148_1143 2.76e-76 234.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,1RMF7@1236|Gammaproteobacteria,1J4M4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0625 Glutathione S-transferase yghU - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_C_2,GST_N k59_229168_1 290397.Adeh_1898 1.56e-24 102.0 COG0500@1|root,COG2226@2|Bacteria,1NV2S@1224|Proteobacteria,43AKS@68525|delta/epsilon subdivisions,2X60S@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_1065528_1 998674.ATTE01000001_gene2171 9.36e-35 135.0 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07673 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA_3 k59_1065528_2 1123399.AQVE01000035_gene3167 1.89e-09 57.4 COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,1RNXI@1236|Gammaproteobacteria,462II@72273|Thiotrichales 72273|Thiotrichales T helix_turn_helix, Lux Regulon - - - ko:K07684 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_173953_1 1267005.KB911257_gene1092 4.34e-135 393.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,3N66U@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_1378127_1 565045.NOR51B_2166 3.17e-29 107.0 COG1937@1|root,COG1937@2|Bacteria,1N9P2@1224|Proteobacteria,1SI5K@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K21600 - - - - ko00000,ko03000 - - - Trns_repr_metal k59_439009_1 748247.AZKH_1847 3.51e-06 53.1 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2VH9X@28216|Betaproteobacteria,2KVFJ@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_439009_2 748247.AZKH_0625 3.93e-39 140.0 2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria,2VUNW@28216|Betaproteobacteria,2KX0T@206389|Rhodocyclales 206389|Rhodocyclales S Protein of Unknown function (DUF2784) - - - - - - - - - - - - DUF2784 k59_1641150_1 1117314.PCIT_18249 1.94e-50 168.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,2PZI0@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0000287,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019899,GO:0022613,GO:0032296,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_1587187_1 1291050.JAGE01000001_gene1467 1.6e-32 122.0 COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,247SC@186801|Clostridia,3WGPU@541000|Ruminococcaceae 186801|Clostridia J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family yacO - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_1378138_1 247634.GPB2148_2971 1.84e-84 263.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1J4IG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_810623_1 395493.BegalDRAFT_0987 1.94e-106 332.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,45ZUC@72273|Thiotrichales 72273|Thiotrichales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_751459_1 1122611.KB903996_gene7610 1.38e-06 56.6 COG2271@1|root,COG2271@2|Bacteria,2H9HJ@201174|Actinobacteria 201174|Actinobacteria G Major facilitator Superfamily - - - ko:K02445 - - - - ko00000,ko02000 2.A.1.4.3 - - MFS_1 k59_810625_1 351348.Maqu_3180 5.2e-153 448.0 COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,1RQA2@1236|Gammaproteobacteria,468B0@72275|Alteromonadaceae 1236|Gammaproteobacteria L PFAM Integrase, catalytic region - - - - - - - - - - - - HTH_23,rve k59_78861_1 164757.Mjls_3794 3.07e-20 84.7 2BZBZ@1|root,348FA@2|Bacteria,2IS25@201174|Actinobacteria,23ASA@1762|Mycobacteriaceae 201174|Actinobacteria S Prokaryotic Cytochrome C oxidase subunit IV - - - - - - - - - - - - COX4_pro k59_78861_2 710686.Mycsm_04574 3.9e-86 258.0 COG1845@1|root,COG1845@2|Bacteria,2I92E@201174|Actinobacteria,2353B@1762|Mycobacteriaceae 201174|Actinobacteria C cytochrome c oxidase, subunit III - - - ko:K02164 - - R00294 RC02794 ko00000 3.D.4.10 - - COX3 k59_594946_1 1188252.AJYK01000085_gene1234 0.000628 48.1 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RPIW@1236|Gammaproteobacteria,1XUZN@135623|Vibrionales 135623|Vibrionales Q Amidohydrolase family - - 3.5.1.81,3.5.1.82 ko:K01461,ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 k59_388827_1 1232410.KI421415_gene2961 1.22e-42 159.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2WJ76@28221|Deltaproteobacteria,43S4V@69541|Desulfuromonadales 28221|Deltaproteobacteria L GIY-YIG type nucleases (URI domain) uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_1434466_1 395493.BegalDRAFT_1704 1.99e-38 134.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,46210@72273|Thiotrichales 72273|Thiotrichales S CcmB protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3 k59_1434466_2 395493.BegalDRAFT_1703 1.22e-32 124.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,461S0@72273|Thiotrichales 72273|Thiotrichales V ABC transporter, ATP-binding protein - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1378149_1 330214.NIDE0749 3.41e-25 102.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding hcf136 - - - - - - - - - - - BNR,Sortilin-Vps10 k59_126212_1 1384056.N787_13935 5.51e-24 108.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X525@135614|Xanthomonadales 135614|Xanthomonadales T PAS fold - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_4,PAS_9 k59_1641187_2 444860.E3SIV6_9CAUD 1.35e-10 59.3 4QH1X@10239|Viruses,4QWX6@35237|dsDNA viruses no RNA stage,4QSHD@28883|Caudovirales,4QKH8@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1323318_1 395493.BegalDRAFT_1891 1.52e-62 207.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,4602R@72273|Thiotrichales 72273|Thiotrichales C NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_751484_1 387093.SUN_1363 1.46e-21 100.0 COG1752@1|root,COG1752@2|Bacteria,1NCAA@1224|Proteobacteria,430CE@68525|delta/epsilon subdivisions 1224|Proteobacteria S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_229218_1 551789.ATVJ01000003_gene382 2.33e-96 298.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2TUZZ@28211|Alphaproteobacteria,43WPD@69657|Hyphomonadaceae 28211|Alphaproteobacteria EU X-Pro dipeptidyl-peptidase (S15 family) - - - - - - - - - - - - DPPIV_N,PD40,Peptidase_S9,Peptidase_S9_N k59_1323323_1 72664.XP_006406977.1 4.32e-35 126.0 COG0526@1|root,KOG0910@2759|Eukaryota,37UUM@33090|Viridiplantae,3GIDN@35493|Streptophyta,3HZMF@3699|Brassicales 35493|Streptophyta O Thioredoxin - GO:0003674,GO:0003824,GO:0004791,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006109,GO:0006950,GO:0006979,GO:0008047,GO:0008150,GO:0008152,GO:0009507,GO:0009526,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0009636,GO:0009719,GO:0009725,GO:0009735,GO:0009941,GO:0009987,GO:0010033,GO:0015035,GO:0015036,GO:0016020,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019222,GO:0019725,GO:0019904,GO:0030234,GO:0030312,GO:0031967,GO:0031975,GO:0031976,GO:0031984,GO:0033554,GO:0034357,GO:0034599,GO:0042221,GO:0042592,GO:0042651,GO:0043085,GO:0043086,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044092,GO:0044093,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051716,GO:0055035,GO:0055114,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071944,GO:0080090,GO:0097237,GO:0098754,GO:0098772,GO:0098869,GO:1990748 - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_334429_1 1121918.ARWE01000001_gene2977 2.47e-150 457.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,42P26@68525|delta/epsilon subdivisions,2WKJ4@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_810673_1 1041522.MCOL_V203515 1.4e-96 285.0 COG3576@1|root,COG3576@2|Bacteria 2|Bacteria S Pyridoxamine 5'-phosphate oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_1488224_1 83406.HDN1F_30750 1e-72 234.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4KP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains glnG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_229227_2 1125863.JAFN01000001_gene1966 4.16e-156 447.0 COG0823@1|root,COG0823@2|Bacteria,1QW3I@1224|Proteobacteria 1224|Proteobacteria U Beta Propeller - - - - - - - - - - - - PD40 k59_229227_3 261292.Nit79A3_2588 2.24e-22 89.7 COG2119@1|root,COG2119@2|Bacteria 2|Bacteria O membrane - - - - - - - - - - - - UPF0016 k59_594987_1 349124.Hhal_0026 3.65e-80 251.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1WW57@135613|Chromatiales 135613|Chromatiales F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily - - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_282016_1 1236959.BAMT01000001_gene1629 2.64e-33 120.0 COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,2VQUQ@28216|Betaproteobacteria,2KMKG@206350|Nitrosomonadales 206350|Nitrosomonadales D TIGRFAM maf protein - - - ko:K06287 - - - - ko00000 - - - Maf k59_282016_2 1000565.METUNv1_00412 6.43e-26 100.0 COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,2VVHG@28216|Betaproteobacteria 28216|Betaproteobacteria M 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_1117525_1 1229172.JQFA01000002_gene2171 4.29e-22 96.7 COG0006@1|root,COG0006@2|Bacteria,1G0KH@1117|Cyanobacteria,1H7YJ@1150|Oscillatoriales 1117|Cyanobacteria E Belongs to the peptidase M24B family pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_1641254_1 700598.Niako_3577 2.03e-119 359.0 COG0422@1|root,COG0422@2|Bacteria,4NFTF@976|Bacteroidetes,1INSZ@117747|Sphingobacteriia 976|Bacteroidetes H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_494821_1 706587.Desti_4889 1.73e-103 326.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MQB6@213462|Syntrophobacterales 28221|Deltaproteobacteria G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1117538_1 710111.FraQA3DRAFT_0083 3.63e-63 209.0 COG0183@1|root,COG0183@2|Bacteria,2GKFR@201174|Actinobacteria,4EVDY@85013|Frankiales 201174|Actinobacteria I lipid-transfer protein - - - - - - - - - - - - - k59_439091_2 713586.KB900536_gene264 1.27e-37 135.0 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,1RMYF@1236|Gammaproteobacteria,1WYQ3@135613|Chromatiales 135613|Chromatiales C Cytochrome c - - - - - - - - - - - - Cytochrom_C k59_595012_2 448385.sce7938 1.97e-62 194.0 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,42R43@68525|delta/epsilon subdivisions,2WPH1@28221|Deltaproteobacteria,2YVAP@29|Myxococcales 28221|Deltaproteobacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_1117540_1 443218.AS9A_3583 8.86e-20 90.5 COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria,235AR@1762|Mycobacteriaceae 201174|Actinobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_1117540_2 1469245.JFBG01000027_gene1473 7.19e-105 318.0 COG1012@1|root,COG1012@2|Bacteria,1QUBI@1224|Proteobacteria,1T3J1@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG1012 NAD-dependent aldehyde dehydrogenases - - 1.1.1.1,1.2.1.10,1.2.1.87 ko:K04072,ko:K13922 ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00640,map00650,map01100,map01110,map01120,map01130,map01220 - R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927,R09097 RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195 ko00000,ko00001,ko01000 - - - Aldedh k59_542289_3 1122135.KB893134_gene3970 1.31e-09 60.1 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2TTGI@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Major facilitator Superfamily aas - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_78961_1 1458357.BG58_25900 3.44e-21 93.6 COG0596@1|root,COG0596@2|Bacteria,1R9X7@1224|Proteobacteria,2VPHU@28216|Betaproteobacteria,1KGYJ@119060|Burkholderiaceae 28216|Betaproteobacteria S Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_701443_1 1163409.UUA_03563 1.42e-09 60.8 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1X3GA@135614|Xanthomonadales 135614|Xanthomonadales P Heavy metal translocating P-type atpase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_856520_2 80884.CCF33846 7.24e-36 136.0 2CNCM@1|root,2QV7T@2759|Eukaryota,39UBR@33154|Opisthokonta,3NZK5@4751|Fungi,3QRU1@4890|Ascomycota,214WD@147550|Sordariomycetes,1F061@1028384|Glomerellales 4751|Fungi S NAD-binding Rossmann fold oxidoreductase family protein - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_542303_1 1123393.KB891332_gene2796 5.85e-72 224.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,1KRNA@119069|Hydrogenophilales 119069|Hydrogenophilales C ATP synthase A chain - - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1378236_1 335543.Sfum_3237 1.81e-56 198.0 COG0515@1|root,COG0515@2|Bacteria,1N9V2@1224|Proteobacteria,42Q0B@68525|delta/epsilon subdivisions,2WJXJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria KLT type IV pilus assembly PilZ - - - - - - - - - - - - - k59_1434578_1 237727.NAP1_15318 6.72e-74 224.0 2DNUQ@1|root,32Z94@2|Bacteria,1N568@1224|Proteobacteria,2UDMU@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF4281) - - - - - - - - - - - - DUF4281 k59_1434578_2 237727.NAP1_15313 3.79e-21 90.9 28PB4@1|root,2ZC42@2|Bacteria,1N88P@1224|Proteobacteria,2UI07@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_543354_2 519989.ECTPHS_06997 1.54e-68 211.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,1WY5U@135613|Chromatiales 135613|Chromatiales K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_661553_2 401526.TcarDRAFT_0841 6.83e-58 189.0 COG4662@1|root,COG4662@2|Bacteria,1TRK7@1239|Firmicutes,4H2EH@909932|Negativicutes 909932|Negativicutes H Binding-protein-dependent transport system inner membrane component - - - ko:K05773 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - BPD_transp_1 k59_235078_1 1301098.PKB_3711 6.67e-15 73.9 COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1SASQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_235078_2 102107.XP_008226688.1 3.86e-06 49.7 COG1231@1|root,KOG0029@2759|Eukaryota,37S7F@33090|Viridiplantae,3GX60@35493|Streptophyta,4JN6W@91835|fabids 35493|Streptophyta Q Lysine-specific histone demethylase 1 homolog - GO:0006325,GO:0006464,GO:0006479,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008213,GO:0009987,GO:0016043,GO:0016569,GO:0016570,GO:0016571,GO:0018022,GO:0018193,GO:0018205,GO:0019538,GO:0032259,GO:0034968,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051276,GO:0051568,GO:0071704,GO:0071840,GO:1901564 - ko:K11450 ko04714,map04714 - - - ko00000,ko00001,ko01000,ko03036 - - - Amino_oxidase,SWIRM k59_1442160_1 388399.SSE37_22437 1.43e-100 300.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily ugpC GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015399,GO:0015405,GO:0015430,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0098656,GO:1901264,GO:1901505 3.6.3.20 ko:K05816 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1.3 - - ABC_tran,TOBE_2 k59_965905_1 1192034.CAP_4962 5.06e-90 276.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2WIYY@28221|Deltaproteobacteria,2YWP3@29|Myxococcales 28221|Deltaproteobacteria S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_502690_1 234267.Acid_0018 2.57e-32 117.0 COG0789@1|root,COG0789@2|Bacteria,3Y56I@57723|Acidobacteria 57723|Acidobacteria K regulatory protein, MerR - - - - - - - - - - - - MerR_1 k59_502690_2 585503.HMPREF7545_0407 2.24e-18 79.0 COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,4H539@909932|Negativicutes 909932|Negativicutes L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hup - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_178885_1 330214.NIDE1358 4.29e-51 176.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,3J0EB@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_1533771_2 632335.Calkr_2381 3.08e-39 140.0 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,42G06@68295|Thermoanaerobacterales 186801|Clostridia P Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_601024_1 765914.ThisiDRAFT_2224 6.09e-06 47.8 COG4726@1|root,COG4726@2|Bacteria,1N7KP@1224|Proteobacteria,1SCM5@1236|Gammaproteobacteria,1WZD1@135613|Chromatiales 135613|Chromatiales NU Type IV pilus assembly protein PilX C-term - - - ko:K02673 - - - - ko00000,ko02035,ko02044 - - - PilX,PilX_N k59_601024_2 1415780.JPOG01000001_gene1584 3.73e-25 105.0 COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,1RZIZ@1236|Gammaproteobacteria,1X5YK@135614|Xanthomonadales 135614|Xanthomonadales NU Type IV Pilus-assembly protein W - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_12402_1 1179778.PMM47T1_24134 3.75e-06 50.8 COG2932@1|root,COG2932@2|Bacteria,1PIRG@1224|Proteobacteria,1S499@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator prtR_1 - - - - - - - - - - - HTH_3,Peptidase_S24 k59_86573_1 243233.MCA1742 4.81e-20 82.8 COG0607@1|root,COG0607@2|Bacteria,1MZPW@1224|Proteobacteria,1THRV@1236|Gammaproteobacteria,1XFHD@135618|Methylococcales 135618|Methylococcales P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_86573_2 1121878.AUGL01000019_gene1537 1.63e-08 59.3 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria 1236|Gammaproteobacteria MU type I secretion outer membrane protein, TolC tolC GO:0002790,GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008104,GO:0008150,GO:0009279,GO:0009306,GO:0009987,GO:0010033,GO:0014070,GO:0015031,GO:0015075,GO:0015267,GO:0015288,GO:0015318,GO:0015562,GO:0015688,GO:0015711,GO:0015833,GO:0015850,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022838,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032940,GO:0032991,GO:0033036,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0042886,GO:0042930,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0046618,GO:0046903,GO:0047485,GO:0050896,GO:0051179,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098796,GO:1901678,GO:1902495,GO:1990195,GO:1990196,GO:1990281,GO:1990351 - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - iAPECO1_1312.APECO1_3378,iEC042_1314.EC042_3326,iECOK1_1307.ECOK1_3463 OEP k59_965919_1 93059.P9211_03881 2.63e-26 111.0 COG1160@1|root,COG1160@2|Bacteria,1G00M@1117|Cyanobacteria,1MKBU@1212|Prochloraceae 1117|Cyanobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der - 1.1.1.399,1.1.1.95 ko:K00058,ko:K03977 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko03009,ko04147 - - - KH_dom-like,MMR_HSR1 k59_446330_1 1521187.JPIM01000136_gene1843 3.92e-31 127.0 COG1132@1|root,COG1132@2|Bacteria,2G66A@200795|Chloroflexi,37630@32061|Chloroflexia 32061|Chloroflexia V PFAM ABC transporter transmembrane region - - - ko:K06147,ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1496178_1 335543.Sfum_2673 1.23e-37 139.0 COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,42Q81@68525|delta/epsilon subdivisions,2WIJ3@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TRAP transporter T-component - - - - - - - - - - - - TAtT k59_1018631_1 330214.NIDE3508 4.03e-48 162.0 28N6F@1|root,2ZBBB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1496190_1 243233.MCA1804 3.36e-130 378.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1XE5H@135618|Methylococcales 135618|Methylococcales I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_1442197_1 1380394.JADL01000001_gene3072 4.89e-09 57.4 COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2TR20@28211|Alphaproteobacteria,2JPF7@204441|Rhodospirillales 204441|Rhodospirillales H ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity - - - ko:K06048 - - - - ko00000,ko01000 - - - GCS2 k59_1442197_2 889378.Spiaf_1047 3.6e-75 236.0 COG0204@1|root,COG0204@2|Bacteria,2J9F7@203691|Spirochaetes 203691|Spirochaetes I Phosphate acyltransferases plsC - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_1496193_1 269799.Gmet_2580 3.23e-82 273.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_133589_2 1379698.RBG1_1C00001G0302 7.61e-12 65.1 COG1539@1|root,COG1539@2|Bacteria,2NQ1A@2323|unclassified Bacteria 2|Bacteria H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB k59_133589_3 1232410.KI421419_gene2516 1.21e-41 149.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,42NBV@68525|delta/epsilon subdivisions,2WK0F@28221|Deltaproteobacteria,43S6X@69541|Desulfuromonadales 28221|Deltaproteobacteria H Molybdenum Cofactor Synthesis C moaA GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM k59_86607_1 754476.Q7A_334 3.14e-24 101.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria,45ZRP@72273|Thiotrichales 72273|Thiotrichales S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_86607_2 1120999.JONM01000028_gene162 5.84e-17 79.3 COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2VK0U@28216|Betaproteobacteria,2KPET@206351|Neisseriales 206351|Neisseriales IQ Enoyl-(Acyl carrier protein) reductase - - 1.5.1.33 ko:K03793 - - - - ko00000,ko01000 - - - adh_short_C2 k59_12431_1 395493.BegalDRAFT_1403 5.06e-24 107.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,463KB@72273|Thiotrichales 72273|Thiotrichales M PFAM Transglycosylase SLT domain - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_1649466_1 1198676.SMUGS5_01420 2.3e-05 48.9 COG0778@1|root,COG0778@2|Bacteria,1V4QZ@1239|Firmicutes,4HHEV@91061|Bacilli 91061|Bacilli C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_288199_1 237368.SCABRO_00011 2.84e-87 264.0 COG1943@1|root,COG1943@2|Bacteria 2|Bacteria L Transposase - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_661676_1 97138.C820_02378 1.1e-73 243.0 COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,36EUN@31979|Clostridiaceae 186801|Clostridia G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_1071700_1 234267.Acid_0809 2e-09 59.3 COG1940@1|root,COG1940@2|Bacteria,3Y4DD@57723|Acidobacteria 57723|Acidobacteria GK ROK family - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK k59_1071700_2 869210.Marky_0040 2.5e-88 273.0 COG1960@1|root,COG1960@2|Bacteria,1WIUP@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1496229_1 344747.PM8797T_10249 7.61e-58 190.0 COG0294@1|root,COG0294@2|Bacteria,2IYYU@203682|Planctomycetes 203682|Planctomycetes H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_757440_1 574966.KB898655_gene1525 7.31e-20 95.1 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1XHF9@135619|Oceanospirillales 135619|Oceanospirillales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_1123654_1 450851.PHZ_c1916 9.23e-79 247.0 COG0614@1|root,COG0614@2|Bacteria,1PK1C@1224|Proteobacteria,2TRF4@28211|Alphaproteobacteria 28211|Alphaproteobacteria P periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_86642_2 936573.HMPREF1147_0229 1.12e-05 52.4 COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,4H2XU@909932|Negativicutes 909932|Negativicutes L ATP-dependent helicase nuclease subunit A addA - 3.6.4.12 ko:K16898 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_1288752_1 1267211.KI669560_gene2065 1.57e-63 204.0 COG4122@1|root,COG4122@2|Bacteria,4NP2A@976|Bacteroidetes,1IXGP@117747|Sphingobacteriia 976|Bacteroidetes S Macrocin-O-methyltransferase (TylF) - - - - - - - - - - - - TylF k59_1123659_1 1380394.JADL01000009_gene3166 1.36e-168 481.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TT67@28211|Alphaproteobacteria,2JQ57@204441|Rhodospirillales 28211|Alphaproteobacteria C Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily - - 1.1.1.1,1.1.1.284,1.1.1.90 ko:K00001,ko:K00055,ko:K00121 ko00010,ko00071,ko00350,ko00360,ko00622,ko00623,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00360,map00622,map00623,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 M00537,M00538 R00623,R00754,R01763,R02124,R02611,R04304,R04805,R04880,R05233,R05234,R05282,R05347,R05348,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N k59_1123663_2 1429916.X566_07840 1.07e-13 70.9 COG3247@1|root,COG3247@2|Bacteria,1RFIH@1224|Proteobacteria,2U5WE@28211|Alphaproteobacteria,3JTES@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Short repeat of unknown function (DUF308) - - - - - - - - - - - - DUF308 k59_393760_1 436308.Nmar_0088 1.43e-161 479.0 COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD/H associated - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_915031_1 444859.E3SIF1_9CAUD 6.15e-06 48.1 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae 10662|Myoviridae S Type III restriction enzyme, res subunit - - - - - - - - - - - - - k59_915031_2 445686.E3SL69_9CAUD 1.06e-67 208.0 4QE8Y@10239|Viruses,4QPGZ@28883|Caudovirales,4QISX@10662|Myoviridae 10662|Myoviridae S Recombination, repair and ssDNA binding protein UvsY - - - - - - - - - - - - - k59_502822_1 932678.THERU_04865 4.81e-09 56.2 COG0680@1|root,COG0680@2|Bacteria,2G4B9@200783|Aquificae 200783|Aquificae C hydrogenase expression formation protein hupD - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI k59_862505_1 563040.Saut_0423 1.39e-17 83.2 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,42QA8@68525|delta/epsilon subdivisions,2YNH6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA_3 k59_601093_1 1307759.JOMJ01000004_gene2635 5.26e-27 115.0 COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,43BMJ@68525|delta/epsilon subdivisions,2WUEV@28221|Deltaproteobacteria,2MH9E@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg,dCache_1 k59_915032_1 639282.DEFDS_1985 8.99e-28 104.0 COG0838@1|root,COG0838@2|Bacteria,2GFSH@200930|Deferribacteres 200930|Deferribacteres C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_915032_2 1191523.MROS_2369 3.45e-53 184.0 COG1007@1|root,COG1007@2|Bacteria 2|Bacteria C ATP synthesis coupled electron transport nuoN GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1123682_1 1101192.KB910516_gene2152 7.28e-47 162.0 COG1946@1|root,COG1946@2|Bacteria,1MV9R@1224|Proteobacteria,2TRFD@28211|Alphaproteobacteria,1JQT1@119045|Methylobacteriaceae 28211|Alphaproteobacteria I TIGRFAM acyl-CoA thioesterase II tesB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575 - ko:K10805 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT_3 k59_288253_1 1122134.KB893651_gene1822 1.43e-31 122.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria,1XHK2@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_288253_2 314256.OG2516_12431 5.26e-16 79.7 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2TRZU@28211|Alphaproteobacteria,2PD44@252301|Oceanicola 28211|Alphaproteobacteria CH FAD binding domain ubiH GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663 - ko:K03185 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04989,R08773 RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_86669_1 935845.JADQ01000025_gene397 1.09e-36 142.0 COG2273@1|root,COG3325@1|root,COG4733@1|root,COG2273@2|Bacteria,COG3325@2|Bacteria,COG4733@2|Bacteria,1UPJ7@1239|Firmicutes,4HBA7@91061|Bacilli,26SGN@186822|Paenibacillaceae 91061|Bacilli G chitinase chiA - 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - GH18 - CBM_2,CBM_5_12,Glyco_hydro_18,fn3 k59_86677_1 469660.A8HNX4_9CAUD 9.75e-19 90.5 4QBFN@10239|Viruses,4QXWN@35237|dsDNA viruses no RNA stage,4QPTW@28883|Caudovirales,4QNPZ@10744|Podoviridae 10744|Podoviridae S Phage stabilisation protein - - - - - - - - - - - - - k59_966000_1 1267533.KB906734_gene3894 9.45e-46 162.0 COG2723@1|root,COG2723@2|Bacteria 2|Bacteria G beta-glucosidase activity blgA - 3.2.1.21 ko:K05350 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - - - Glyco_hydro_1 k59_966000_2 1121374.KB891576_gene573 2.07e-05 52.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG0457 FOG TPR repeat - - - - - - - - - - - - Sulfotransfer_3,TPR_16,TPR_8 k59_1443164_1 1229909.NSED_04850 5.83e-109 324.0 COG0064@1|root,arCOG01718@2157|Archaea,41S9S@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_1290131_1 439235.Dalk_1753 6.36e-94 285.0 COG0300@1|root,COG0623@1|root,COG0300@2|Bacteria,COG0623@2|Bacteria,1R090@1224|Proteobacteria,43CRU@68525|delta/epsilon subdivisions,2X7ZF@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_1290131_2 889378.Spiaf_2283 4.1e-51 172.0 COG0332@1|root,COG0332@2|Bacteria,2J6DC@203691|Spirochaetes 2|Bacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids - - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_1650903_1 448385.sce8998 1.29e-26 111.0 COG0438@1|root,COG0438@2|Bacteria,1MX12@1224|Proteobacteria 1224|Proteobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_447544_1 349521.HCH_04688 7.54e-15 75.1 COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,1S9D2@1236|Gammaproteobacteria,1XRWV@135619|Oceanospirillales 135619|Oceanospirillales M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1125106_1 436308.Nmar_1309 5.33e-62 211.0 COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S7I@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18594 ko00720,ko01120,map00720,map01120 - R03157 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_863440_1 1123368.AUIS01000005_gene373 2.61e-64 205.0 COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,1RMUT@1236|Gammaproteobacteria,2NCNK@225057|Acidithiobacillales 225057|Acidithiobacillales H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth k59_1534719_1 595460.RRSWK_01369 2.06e-98 303.0 COG3119@1|root,COG3119@2|Bacteria,2J2DF@203682|Planctomycetes 203682|Planctomycetes P Sulfatase - - - - - - - - - - - - Sulfatase k59_758408_1 1123371.ATXH01000006_gene825 4.52e-173 510.0 COG1674@1|root,COG1674@2|Bacteria,2GHMR@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria D Ftsk_gamma - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_916392_1 566466.NOR53_3413 2.73e-34 135.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Adenylate cyclase - - - - - - - - - - - - TPR_16 k59_663175_1 756067.MicvaDRAFT_3616 7.16e-12 70.9 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1G3H3@1117|Cyanobacteria,1H887@1150|Oscillatoriales 1117|Cyanobacteria T Cache domain - - - - - - - - - - - - GAF,HATPase_c,HisKA,dCache_1 k59_289669_1 1108045.GORHZ_069_00220 7.66e-32 127.0 COG0318@1|root,COG0318@2|Bacteria,2GMVB@201174|Actinobacteria,4GCCM@85026|Gordoniaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K04116 ko00362,ko01120,map00362,map01120 M00540 R05620 RC00004,RC01438 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C k59_1233951_1 377629.TERTU_0069 5.81e-67 226.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,2PN76@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L 5'-3' exonuclease polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_236197_1 1340493.JNIF01000004_gene421 7.85e-91 294.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Cytochrom_C,PA,TSP_3 k59_820230_2 768671.ThimaDRAFT_0532 9.36e-12 63.5 2CHAX@1|root,32ZC9@2|Bacteria,1N6X2@1224|Proteobacteria,1SGKD@1236|Gammaproteobacteria,1WYKI@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF3301) - - - - - - - - - - - - DUF3301 k59_1073113_1 1469245.JFBG01000038_gene1823 4.72e-124 380.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhA - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_179822_1 765914.ThisiDRAFT_2315 1.49e-87 288.0 COG0187@1|root,COG1372@1|root,COG0187@2|Bacteria,COG1372@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_394658_1 1333998.M2A_1715 3.4e-05 46.6 COG0625@1|root,COG0625@2|Bacteria,1Q05U@1224|Proteobacteria,2U5IH@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_394658_2 1116472.MGMO_45c00020 7.2e-36 125.0 2EJWJ@1|root,33DM8@2|Bacteria,1NNFZ@1224|Proteobacteria,1SHVK@1236|Gammaproteobacteria,1XFJC@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - k59_94435_1 1123237.Salmuc_00473 9.07e-87 276.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria 28211|Alphaproteobacteria EQ N-methylhydantoinase A acetone carboxylase, beta subunit - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_347895_1 909663.KI867150_gene333 4.83e-81 262.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MQB9@213462|Syntrophobacterales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane - - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SecA_DEAD,SecA_PP_bind k59_183940_1 330214.NIDE2567 9.05e-114 337.0 COG0436@1|root,COG0436@2|Bacteria,3J0EV@40117|Nitrospirae 40117|Nitrospirae E Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_762705_1 203122.Sde_1797 9.27e-52 180.0 COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria,464YM@72275|Alteromonadaceae 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494 1.6.5.8 ko:K00346 - - - - ko00000,ko01000 - - - NQRA,NQRA_SLBB k59_1239959_1 565653.EGBG_01132 6.31e-37 138.0 COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,4AZE3@81852|Enterococcaceae 91061|Bacilli D Phage integrase, N-terminal SAM-like domain xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_15803_1 292415.Tbd_0568 1.72e-33 130.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,1KRKZ@119069|Hydrogenophilales 119069|Hydrogenophilales S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48,TPR_19 k59_1598361_2 102125.Xen7305DRAFT_00036510 9.88e-38 140.0 COG0438@1|root,COG0438@2|Bacteria,1G41W@1117|Cyanobacteria,3VMKI@52604|Pleurocapsales 1117|Cyanobacteria M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1389030_1 525909.Afer_1569 5.09e-93 296.0 COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4CMWW@84992|Acidimicrobiia 84992|Acidimicrobiia C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_94466_1 316067.Geob_3079 4.61e-10 60.5 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_398998_1 748247.AZKH_1671 1.93e-69 222.0 COG0845@1|root,COG0845@2|Bacteria,1PJHF@1224|Proteobacteria,2VIRN@28216|Betaproteobacteria 28216|Betaproteobacteria M TIGRFAM efflux transporter, RND family, MFP subunit - - - ko:K02005 - - - - ko00000 - - - HlyD_3 k59_398998_2 292459.STH636 5.89e-67 218.0 COG3876@1|root,COG3876@2|Bacteria,1VRMG@1239|Firmicutes,24CF8@186801|Clostridia 186801|Clostridia F Protein of unknown function (DUF1343) - - - - - - - - - - - - Cu_amine_oxidN1,DUF1343 k59_1131516_1 1121918.ARWE01000001_gene911 1.74e-09 60.8 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,43SBG@69541|Desulfuromonadales 28221|Deltaproteobacteria M HlyD family secretion protein - - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - DUF3347,HlyD_D23 k59_1131516_2 1121930.AQXG01000035_gene28 4.25e-07 55.8 COG1538@1|root,COG1538@2|Bacteria,4NDXW@976|Bacteroidetes 976|Bacteroidetes MU PFAM Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1024155_2 1229909.NSED_09100 1.97e-70 214.0 arCOG03681@1|root,arCOG03681@2157|Archaea,41T6V@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1024155_3 1229909.NSED_09095 2.47e-13 69.3 COG0661@1|root,arCOG01189@2157|Archaea,41SYQ@651137|Thaumarchaeota 651137|Thaumarchaeota S ABC1 family - - - - - - - - - - - - ABC1 k59_606050_1 1279009.ADICEAN_03044 1.75e-28 114.0 COG1066@1|root,COG1066@2|Bacteria,4NEYA@976|Bacteroidetes,47K0I@768503|Cytophagia 976|Bacteroidetes O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_606050_2 596152.DesU5LDRAFT_0478 1.1e-06 51.2 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2M8P4@213115|Desulfovibrionales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K04076 - - - - ko00000,ko01000,ko01002 - - - AAA_32,Lon_C k59_1131523_1 1157490.EL26_15815 3.99e-34 130.0 COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,277XE@186823|Alicyclobacillaceae 91061|Bacilli D Tyrosine recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_1131523_2 985665.HPL003_18105 2.35e-38 143.0 COG1206@1|root,COG1206@2|Bacteria,1TP67@1239|Firmicutes,4HB27@91061|Bacilli,26QW5@186822|Paenibacillaceae 91061|Bacilli J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs trmFO GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 ko:K04094 - - - - ko00000,ko01000,ko03016,ko03036 - - - GIDA k59_1177420_1 316274.Haur_3415 8.72e-41 149.0 COG2308@1|root,COG2308@2|Bacteria,2GACA@200795|Chloroflexi,37575@32061|Chloroflexia 32061|Chloroflexia S A circularly permuted ATPgrasp - - - - - - - - - - - - CP_ATPgrasp_2 k59_241089_1 1125701.HMPREF1221_02185 0.000993 47.8 COG0517@1|root,COG0517@2|Bacteria,2J6JU@203691|Spirochaetes 203691|Spirochaetes S CBS domain - - - ko:K04767 - - - - ko00000 - - - ACT,CBS k59_241089_2 1229909.NSED_02950 4.3e-45 153.0 COG1938@1|root,arCOG00347@2157|Archaea 2157|Archaea S COG1938 Archaeal enzymes of ATP-grasp superfamily - - - ko:K06869 - - - - ko00000 - - - PAC2 k59_15859_1 543913.D521_1700 2.99e-80 265.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,1KPMX@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_295837_1 1335757.SPICUR_07265 2.05e-66 212.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1WXNW@135613|Chromatiales 135613|Chromatiales E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_295837_2 472759.Nhal_0322 1.46e-06 49.7 COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,1WWHF@135613|Chromatiales 135613|Chromatiales EGP Major facilitator superfamily - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_1333615_1 686340.Metal_0402 1.6e-105 319.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1XDV5@135618|Methylococcales 135618|Methylococcales J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_453834_1 1215092.PA6_002_00290 8.6e-13 67.0 COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,1S4SZ@1236|Gammaproteobacteria,1YFYU@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Lipocalin-like domain blc - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_453834_2 1123242.JH636434_gene5469 6.99e-32 118.0 COG2818@1|root,COG2818@2|Bacteria,2IZYU@203682|Planctomycetes 203682|Planctomycetes L Methyladenine glycosylase - - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_713177_1 1144305.PMI02_04751 7.94e-37 141.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2K20D@204457|Sphingomonadales 204457|Sphingomonadales EQ PFAM Hydantoinase oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_1132578_1 1229909.NSED_02165 7.2e-89 264.0 arCOG08663@1|root,arCOG08663@2157|Archaea,41SR2@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1080523_1 1229909.NSED_00105 6.76e-87 266.0 COG2073@1|root,arCOG00651@2157|Archaea,41S83@651137|Thaumarchaeota 651137|Thaumarchaeota H Cobalamin synthesis G C-terminus - - 3.7.1.12 ko:K02189 ko00860,ko01100,map00860,map01100 - R07772 RC01545,RC02097 ko00000,ko00001,ko01000 - - - CbiG_C,CbiG_N,CbiG_mid k59_16274_1 436308.Nmar_0482 1.09e-79 244.0 COG0581@1|root,arCOG00168@2157|Archaea,41SZ4@651137|Thaumarchaeota 651137|Thaumarchaeota P TIGRFAM phosphate ABC transporter - - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_828183_1 1304275.C41B8_18104 7.76e-54 190.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1298004_1 264732.Moth_2231 1.32e-18 85.9 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,42EZK@68295|Thermoanaerobacterales 186801|Clostridia L PFAM RNA-directed DNA polymerase (Reverse transcriptase) - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_1080536_1 743299.Acife_0974 7.66e-85 261.0 COG0530@1|root,COG0530@2|Bacteria,1QD22@1224|Proteobacteria,1RQXR@1236|Gammaproteobacteria,2NBR9@225057|Acidithiobacillales 225057|Acidithiobacillales P Sodium calcium exchanger - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_828193_1 1260251.SPISAL_05310 3.56e-39 132.0 COG4517@1|root,COG4517@2|Bacteria,1MZJX@1224|Proteobacteria,1S95D@1236|Gammaproteobacteria,1WZ3B@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF1820) - - - - - - - - - - - - DUF1820 k59_1132603_1 1197706.AKKK01000010_gene690 4.03e-29 113.0 COG0241@1|root,COG0241@2|Bacteria,2GK77@201174|Actinobacteria 201174|Actinobacteria E D,D-heptose 1,7-bisphosphate phosphatase gmhB - - - - - - - - - - - Glycos_transf_2,Hydrolase_like k59_1505653_1 1123368.AUIS01000013_gene832 1.15e-38 132.0 COG4911@1|root,COG4911@2|Bacteria,1NPJ8@1224|Proteobacteria,1T8JU@1236|Gammaproteobacteria,2ND17@225057|Acidithiobacillales 225057|Acidithiobacillales S Uncharacterized conserved protein (DUF2203) - - - - - - - - - - - - DUF2203 k59_1505653_2 644801.Psest_3380 2.39e-33 123.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1Z05W@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria H Belongs to the ribF family ribF GO:0003674,GO:0003824,GO:0003919,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008531,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0044237,GO:0070566 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iETEC_1333.ETEC_0025,iJN746.PP_0602 FAD_syn,Flavokinase k59_1505663_1 644282.Deba_1140 4.88e-95 305.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_1298042_1 472759.Nhal_2902 2e-92 284.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1WWGK@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase, dimerisation - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_828234_1 670292.JH26_00425 1.43e-120 352.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,1JTSW@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_21,rve,rve_3 k59_828234_2 314260.PB2503_12544 3.42e-34 119.0 COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_Tnp_1 k59_1298043_1 1137799.GZ78_24595 2.12e-09 60.1 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1XI5I@135619|Oceanospirillales 135619|Oceanospirillales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_349061_1 314285.KT71_09662 1.69e-60 196.0 COG3637@1|root,COG3637@2|Bacteria,1RI4B@1224|Proteobacteria,1S8IK@1236|Gammaproteobacteria,1J6HR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl k59_1658975_1 1380394.JADL01000010_gene4133 3.89e-63 208.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TR6K@28211|Alphaproteobacteria,2JQ8V@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_924004_2 690850.Desaf_1238 3.6e-57 182.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,42SFB@68525|delta/epsilon subdivisions,2WP3B@28221|Deltaproteobacteria,2MBZA@213115|Desulfovibrionales 28221|Deltaproteobacteria U PFAM type II secretion system protein G gspG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_554968_1 391615.ABSJ01000029_gene1949 9.27e-100 305.0 COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,1RM9I@1236|Gammaproteobacteria,1J4BV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1252 NADH dehydrogenase, FAD-containing subunit ndh - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1298054_1 395494.Galf_2389 3.72e-21 92.4 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2VIBJ@28216|Betaproteobacteria,44WDP@713636|Nitrosomonadales 28216|Betaproteobacteria K Transcriptional regulator, LysR family oxyR - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_828251_1 398580.Dshi_1440 1.67e-67 216.0 COG0583@1|root,COG0583@2|Bacteria,1R4QT@1224|Proteobacteria,2TRGQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator, LysR family - - - ko:K21645 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1539655_1 362242.MUL_4362 3.07e-36 134.0 COG2015@1|root,COG2015@2|Bacteria,2H3T3@201174|Actinobacteria,235UZ@1762|Mycobacteriaceae 201174|Actinobacteria Q Metallo-beta-lactamase superfamily - - - - - - - - - - - - Alkyl_sulf_dimr,Lactamase_B k59_1539655_2 101510.RHA1_ro05719 1.36e-69 224.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4FUH9@85025|Nocardiaceae 201174|Actinobacteria Q Cytochrome P450 - - - ko:K21119 - - - - ko00000,ko00199 - - - p450 k59_1334432_1 1288494.EBAPG3_11630 3.71e-109 327.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2VH57@28216|Betaproteobacteria,371NP@32003|Nitrosomonadales 28216|Betaproteobacteria F May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_1658998_1 436308.Nmar_0651 1.19e-126 392.0 COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota 651137|Thaumarchaeota D SMC proteins Flexible Hinge Domain - - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1599220_1 96561.Dole_1980 4.47e-10 61.2 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42MNA@68525|delta/epsilon subdivisions,2WK7Z@28221|Deltaproteobacteria,2MIPV@213118|Desulfobacterales 28221|Deltaproteobacteria OU signal peptide peptidase SppA sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_1599220_2 717773.Thicy_0813 7.86e-15 77.8 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,45ZMR@72273|Thiotrichales 72273|Thiotrichales J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_671096_1 1249627.D779_2783 9.27e-58 193.0 COG1653@1|root,COG1653@2|Bacteria,1MX9J@1224|Proteobacteria,1S09S@1236|Gammaproteobacteria,1WXY8@135613|Chromatiales 135613|Chromatiales G extracellular solute-binding - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 k59_512298_1 330214.NIDE0495 5.12e-130 377.0 COG0741@1|root,COG0741@2|Bacteria,3J0J4@40117|Nitrospirae 2|Bacteria M Lysin motif mltD_2 - - - - - - - - - - - LysM,SLT k59_16300_1 1499967.BAYZ01000113_gene2934 1.54e-06 48.9 COG0250@1|root,COG0250@2|Bacteria,2NPAP@2323|unclassified Bacteria 2|Bacteria K Participates in transcription elongation, termination and antitermination nusG GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_16300_2 1123267.JONN01000001_gene1612 3.42e-54 174.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,2U760@28211|Alphaproteobacteria,2K3Z9@204457|Sphingomonadales 204457|Sphingomonadales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_1389891_1 1232410.KI421425_gene1565 2.79e-51 183.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,43TY6@69541|Desulfuromonadales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain actB - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1599229_1 1266925.JHVX01000004_gene1236 2.16e-77 244.0 COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,2VNGV@28216|Betaproteobacteria,3742G@32003|Nitrosomonadales 28216|Betaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1389897_1 305900.GV64_00785 8.42e-18 80.1 2CKE6@1|root,32ZEV@2|Bacteria,1NBRM@1224|Proteobacteria,1SCY3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Family of unknown function (DUF5329) - - - - - - - - - - - - DUF5329 k59_1389898_1 1172188.KB911820_gene2097 1.57e-77 244.0 COG0189@1|root,COG0189@2|Bacteria,2I75I@201174|Actinobacteria,4FEMX@85021|Intrasporangiaceae 201174|Actinobacteria HJ Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain - - - - - - - - - - - - CPSase_L_D2 k59_1298098_1 998674.ATTE01000001_gene184 1.11e-22 96.7 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,45ZUX@72273|Thiotrichales 72273|Thiotrichales L DNA helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_606911_1 1005048.CFU_2012 1.5e-75 236.0 COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2VJFW@28216|Betaproteobacteria,4734F@75682|Oxalobacteraceae 28216|Betaproteobacteria H Ketopantoate reductase PanE/ApbA C terminal panE - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_763682_1 330214.NIDE0767 1.58e-73 233.0 COG0206@1|root,COG0206@2|Bacteria,3J0D4@40117|Nitrospirae 40117|Nitrospirae D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_16307_1 1333998.M2A_2512 7.2e-66 215.0 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,2U1SE@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_833783_1 1122613.ATUP01000001_gene604 2.05e-11 67.4 COG0517@1|root,COG0517@2|Bacteria,1Q3NA@1224|Proteobacteria,2VACX@28211|Alphaproteobacteria,43ZV8@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_1084532_1 472759.Nhal_3855 1.57e-14 67.0 COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,1SHHF@1236|Gammaproteobacteria,1WZR6@135613|Chromatiales 135613|Chromatiales S Zinc-finger domain - - - - - - - - - - - - zf-CHCC k59_1084532_2 1005999.GLGR_3215 3.17e-49 168.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,1RMBF@1236|Gammaproteobacteria 1236|Gammaproteobacteria M heptosyltransferase rfaF GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 iECH74115_1262.ECH74115_4993,iECSP_1301.ECSP_4617,iECs_1301.ECs4498,iG2583_1286.G2583_4359,iZ_1308.Z5047 Glyco_transf_9 k59_1084533_1 489825.LYNGBM3L_21220 1.29e-74 247.0 COG1216@1|root,COG5309@1|root,COG1216@2|Bacteria,COG5309@2|Bacteria,1G2MT@1117|Cyanobacteria,1H8YG@1150|Oscillatoriales 1117|Cyanobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glyco_hydro_2_C,Glycos_transf_2 k59_403478_1 436308.Nmar_0240 1.64e-68 216.0 COG0470@1|root,arCOG00469@2157|Archaea,41SFJ@651137|Thaumarchaeota 651137|Thaumarchaeota L Replication factor C - - - ko:K04801 ko03030,map03030 - - - ko00000,ko00001,ko03032 - - - DNA_pol3_delta2,Rep_fac_C,RuvB_N k59_610455_1 62928.azo0149 4.96e-59 196.0 COG2159@1|root,COG2159@2|Bacteria,1R7E1@1224|Proteobacteria,2VPY4@28216|Betaproteobacteria,2KVED@206389|Rhodocyclales 206389|Rhodocyclales S Amidohydrolase uxuA - 4.2.1.8 ko:K01686 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_2 k59_188375_1 1298864.AUEQ01000001_gene4580 2.65e-66 216.0 COG4992@1|root,COG4992@2|Bacteria,2GIYG@201174|Actinobacteria,234P4@1762|Mycobacteriaceae 201174|Actinobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_976608_1 1517416.IDAT_11775 7.79e-07 50.4 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,2QFR8@267893|Idiomarinaceae 1236|Gammaproteobacteria K RNA polymerase sigma rpoH GO:0000150,GO:0000976,GO:0000984,GO:0000985,GO:0000988,GO:0000990,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006310,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009009,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031421,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2001141 - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_976608_2 1304275.C41B8_12180 2.55e-39 142.0 COG0730@1|root,COG0730@2|Bacteria,1MVBS@1224|Proteobacteria,1S62V@1236|Gammaproteobacteria 1236|Gammaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_1029014_1 999141.GME_05480 9.53e-17 81.3 COG0739@1|root,COG3061@1|root,COG0739@2|Bacteria,COG3061@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1XIJI@135619|Oceanospirillales 135619|Oceanospirillales M Peptidase M23 - - - ko:K19304 - - - - ko00000,ko01000,ko01002,ko01011 - - - OapA,Peptidase_M23 k59_1029014_2 331869.BAL199_18108 5.13e-113 352.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,4BP6T@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_517760_1 1220535.IMCC14465_03730 4.11e-32 127.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2UTT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_353126_1 546274.EIKCOROL_00674 2.55e-28 120.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2VH1K@28216|Betaproteobacteria,2KQ01@206351|Neisseriales 206351|Neisseriales O ATP-dependent Clp protease ATP-binding subunit clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_188385_2 1123023.JIAI01000001_gene7174 8.38e-43 153.0 COG0045@1|root,COG0045@2|Bacteria,2H1R3@201174|Actinobacteria,4E8ER@85010|Pseudonocardiales 201174|Actinobacteria C ATP-grasp domain - - - - - - - - - - - - ATP-grasp_2,Ligase_CoA k59_188386_1 1207063.P24_12157 1.5e-150 434.0 COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria,2JRJN@204441|Rhodospirillales 204441|Rhodospirillales I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1029028_1 1353537.TP2_05010 1.81e-07 58.2 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2TR45@28211|Alphaproteobacteria,2XN56@285107|Thioclava 28211|Alphaproteobacteria S TamB, inner membrane protein subunit of TAM complex tamB - - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_976626_2 1297742.A176_06938 4.9e-72 232.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,2YU4Q@29|Myxococcales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa k59_1543321_1 1265313.HRUBRA_00472 4.78e-35 137.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1J54G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080 AIRS_C,GATase_5 k59_146392_1 1219031.BBJR01000022_gene2540 2.7e-21 89.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2VQ16@28216|Betaproteobacteria,4ADKA@80864|Comamonadaceae 28216|Betaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_146392_2 391623.TERMP_01367 2.73e-109 330.0 COG1568@1|root,arCOG00913@2157|Archaea,2XTMN@28890|Euryarchaeota,242J8@183968|Thermococci 183968|Thermococci H Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high- temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S- adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine bpsA GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:1901564,GO:1901566,GO:1901576 2.5.1.128 ko:K07057 - - - - ko00000,ko01000 - - - DUF43 k59_354348_2 575540.Isop_1280 6.86e-12 70.9 COG1663@1|root,COG1663@2|Bacteria,2IXYX@203682|Planctomycetes 203682|Planctomycetes F Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK k59_611729_2 1121448.DGI_1916 5.87e-07 52.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2WJ64@28221|Deltaproteobacteria,2M8AS@213115|Desulfovibrionales 28221|Deltaproteobacteria IQ PFAM Short-chain dehydrogenase reductase SDR fabG-2 - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_873830_1 1121374.KB891585_gene2028 6.9e-65 214.0 COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria 1236|Gammaproteobacteria CP PFAM NADH Ubiquinone plastoquinone (complex I) - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M,Proton_antipo_N k59_873830_2 1278309.KB907101_gene693 5.33e-66 218.0 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1XHVS@135619|Oceanospirillales 135619|Oceanospirillales CP COG0651 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_189639_1 439235.Dalk_1366 4.12e-72 225.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2WIXU@28221|Deltaproteobacteria,2MHNJ@213118|Desulfobacterales 28221|Deltaproteobacteria M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_302268_1 1265313.HRUBRA_00522 4.09e-60 207.0 COG1231@1|root,COG1231@2|Bacteria,1QXX6@1224|Proteobacteria,1T3IZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - 1.5.99.6 ko:K00316 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R01914,R01915 RC00053,RC00225 ko00000,ko00001,ko01000 - - - NAD_binding_8 k59_100951_1 5145.XP_001907721.1 1.35e-06 58.2 COG0642@1|root,KOG0519@2759|Eukaryota,38EIJ@33154|Opisthokonta,3NVY0@4751|Fungi,3QKZV@4890|Ascomycota,211WS@147550|Sordariomycetes,3U939@5139|Sordariales 4751|Fungi T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_519559_2 439235.Dalk_5107 9.88e-54 187.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,2MIKW@213118|Desulfobacterales 28221|Deltaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1182621_1 644548.SCNU_11745 9.75e-40 140.0 COG1024@1|root,COG1024@2|Bacteria,2GJY4@201174|Actinobacteria,4GAX5@85026|Gordoniaceae 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_1182621_2 591158.SSMG_03009 1.09e-15 76.6 COG1960@1|root,COG1960@2|Bacteria,2ICK3@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1394206_1 243233.MCA2386 5.28e-52 171.0 COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,1XE07@135618|Methylococcales 135618|Methylococcales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrD - 1.6.5.8 ko:K00349 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_1666313_1 768671.ThimaDRAFT_2422 1.98e-26 105.0 COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,1WXGQ@135613|Chromatiales 135613|Chromatiales S High frequency lysogenization protein HflD homolog hflD - - ko:K07153 - - - - ko00000 - - - DUF489 k59_1666313_2 1198232.CYCME_0904 2.18e-61 203.0 COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,460CG@72273|Thiotrichales 72273|Thiotrichales M N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,LysM k59_1245647_1 1382356.JQMP01000004_gene440 2.3e-42 151.0 COG0547@1|root,COG0547@2|Bacteria,2G5YV@200795|Chloroflexi,27XT8@189775|Thermomicrobia 189775|Thermomicrobia F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_404797_1 1229909.NSED_06400 3.37e-95 289.0 COG3794@1|root,arCOG08764@1|root,arCOG02926@2157|Archaea,arCOG08764@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind k59_1512914_1 717773.Thicy_0455 2.05e-94 291.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,45ZX7@72273|Thiotrichales 72273|Thiotrichales F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_678502_2 215803.DB30_3610 2.86e-10 60.8 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42NDG@68525|delta/epsilon subdivisions,2WKYU@28221|Deltaproteobacteria,2YU64@29|Myxococcales 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1305503_1 349163.Acry_2757 1.19e-41 142.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,2TU1S@28211|Alphaproteobacteria,2JRQP@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_1305503_2 1121374.KB891576_gene511 2.15e-20 88.6 28NHW@1|root,2ZBJG@2|Bacteria,1RBJB@1224|Proteobacteria,1S31B@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1512915_2 330214.NIDE2210 1.21e-10 61.6 COG2890@1|root,COG2890@2|Bacteria 2|Bacteria J protein-(glutamine-N5) methyltransferase activity - - 2.1.1.156,2.1.1.157,2.1.1.209,2.1.1.4 ko:K00543,ko:K16130,ko:K18896,ko:K18897,ko:K21515 ko00260,ko00380,ko01054,ko01100,map00260,map00380,map01054,map01100 M00037 R03130,R04905,R10060,R10061 RC00003,RC00392,RC03038,RC03040 ko00000,ko00001,ko00002,ko01000,ko01008,ko03009 - - - AMP-binding,Aminotran_1_2,AviRa,Condensation,Dimerisation2,Hen1_L,Methyltransf_12,Methyltransf_2,Methyltransf_23,Methyltransf_25,Methyltransf_31,PP-binding k59_519589_1 717785.HYPMC_3255 1.09e-08 53.5 2E7PS@1|root,3325B@2|Bacteria,1N7R7@1224|Proteobacteria,2UFCM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - k59_519589_2 1336233.JAEH01000005_gene1845 1.45e-22 97.4 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,2Q8QH@267890|Shewanellaceae 1236|Gammaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1512916_1 330214.NIDE2638 1.33e-76 253.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,3J0ZS@40117|Nitrospirae 40117|Nitrospirae C FAD linked oxidases, C-terminal domain - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_100976_1 1232410.KI421420_gene3227 3.65e-119 373.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43U53@69541|Desulfuromonadales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran,OEP k59_1666338_1 396588.Tgr7_0643 1.05e-51 167.0 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,1WY9X@135613|Chromatiales 135613|Chromatiales S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_835680_1 436308.Nmar_0476 2.52e-116 337.0 COG0842@1|root,arCOG01467@2157|Archaea,41SQQ@651137|Thaumarchaeota 651137|Thaumarchaeota V PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_719356_2 1509405.GV67_08610 3e-17 80.9 COG0028@1|root,COG0028@2|Bacteria,1N4U6@1224|Proteobacteria,2U0I6@28211|Alphaproteobacteria,4BDDC@82115|Rhizobiaceae 28211|Alphaproteobacteria EH Belongs to the TPP enzyme family - - - - - - - - - - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_247302_1 438753.AZC_1170 1.32e-38 149.0 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,3EY5I@335928|Xanthobacteraceae 28211|Alphaproteobacteria E 2Fe-2S iron-sulfur cluster binding domain soxA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.5.3.1,1.5.99.5 ko:K00302,ko:K22086 ko00260,ko00680,ko01100,ko01120,map00260,map00680,map01100,map01120 - R00609,R00610 RC00060,RC00190,RC00557 ko00000,ko00001,ko01000 - - - FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2 k59_719358_2 1408312.JNJS01000002_gene97 3.35e-11 60.5 COG0236@1|root,COG0236@2|Bacteria,1VGGM@1239|Firmicutes,24Q2V@186801|Clostridia,3NICV@46205|Pseudobutyrivibrio 186801|Clostridia IQ Phosphopantetheine attachment site - - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_873871_1 1082931.KKY_433 3.42e-16 84.0 COG0277@1|root,COG2141@1|root,COG0277@2|Bacteria,COG2141@2|Bacteria,1MUPW@1224|Proteobacteria,2TUNK@28211|Alphaproteobacteria,3N8TH@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria C Berberine and berberine like - - - - - - - - - - - - BBE,Cytokin-bind,FAD_binding_4 k59_835690_2 395493.BegalDRAFT_0708 1.81e-139 417.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,45ZU0@72273|Thiotrichales 72273|Thiotrichales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_459661_1 243233.MCA1465 1.45e-75 234.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1XEDU@135618|Methylococcales 135618|Methylococcales U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_835691_1 927677.ALVU02000001_gene1806 1.74e-71 221.0 COG5485@1|root,COG5485@2|Bacteria,1GCKP@1117|Cyanobacteria 1117|Cyanobacteria S Ester cyclase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - SnoaL k59_1452846_1 1150600.ADIARSV_1086 3.54e-114 345.0 COG1282@1|root,COG1282@2|Bacteria,4NHGZ@976|Bacteroidetes,1IPVT@117747|Sphingobacteriia 976|Bacteroidetes C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_146454_1 909663.KI867150_gene491 2.36e-28 114.0 COG0204@1|root,COG0204@2|Bacteria 2|Bacteria I Acyl-transferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_1030327_1 913325.N799_11720 2.5e-58 203.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1X3ME@135614|Xanthomonadales 135614|Xanthomonadales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1137872_1 1288494.EBAPG3_24610 4.25e-60 195.0 COG1073@1|root,COG1073@2|Bacteria,1QUQB@1224|Proteobacteria,2W8W8@28216|Betaproteobacteria,373YM@32003|Nitrosomonadales 28216|Betaproteobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - - k59_1305553_2 1172185.KB911515_gene2154 3.95e-07 55.8 2BYTM@1|root,2Z7KC@2|Bacteria,2GJ6K@201174|Actinobacteria,4FU8Z@85025|Nocardiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_835714_1 579405.Dd703_0346 1.12e-40 140.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1RP9U@1236|Gammaproteobacteria,2JDZ0@204037|Dickeya 1236|Gammaproteobacteria M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiA GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K01802,ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_835714_2 146922.JOFU01000018_gene3402 1.48e-07 54.7 COG0436@1|root,COG0436@2|Bacteria,2GPM3@201174|Actinobacteria 201174|Actinobacteria E Pfam Aminotransferase class I and II - - 2.6.1.1 ko:K11358 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_101008_1 1415778.JQMM01000001_gene1543 1.57e-11 67.4 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1J5PD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS GO:0002097,GO:0002101,GO:0002136,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0032267,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_519641_1 693746.OBV_39000 1.38e-07 54.3 COG0583@1|root,COG0583@2|Bacteria,1V0PG@1239|Firmicutes,24ETJ@186801|Clostridia,2N7QF@216572|Oscillospiraceae 186801|Clostridia K Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_519641_2 93220.LV28_00815 7.38e-15 73.2 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2VHWS@28216|Betaproteobacteria,1K38Q@119060|Burkholderiaceae 28216|Betaproteobacteria C Isocitrate lyase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_560307_1 395493.BegalDRAFT_2504 1.1e-94 288.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,461J8@72273|Thiotrichales 72273|Thiotrichales I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1512967_1 330214.NIDE3309 1.44e-19 89.4 COG1413@1|root,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity - - - - - - - - - - - - HEAT,HEAT_2,HEAT_PBS k59_354417_1 1254432.SCE1572_26325 3.22e-58 201.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria,2YUFW@29|Myxococcales 28221|Deltaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_1137881_1 330214.NIDE0557 1.14e-24 105.0 COG0642@1|root,COG0745@1|root,COG2203@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria 2|Bacteria T PhoQ Sensor - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA k59_1137881_2 330214.NIDE2763 5.02e-52 165.0 COG0011@1|root,COG0011@2|Bacteria,3J0QD@40117|Nitrospirae 40117|Nitrospirae S Thiamine-binding protein - - - - - - - - - - - - Thiamine_BP k59_1137881_3 330214.NIDE2764 1.8e-31 115.0 COG1648@1|root,COG1648@2|Bacteria 2|Bacteria H precorrin-2 dehydrogenase activity cysG GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302,ko:K02304 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - iECIAI1_1343.ECIAI1_3507,iECSE_1348.ECSE_3630,iEcE24377_1341.EcE24377A_3838,iJN746.PP_3999,iPC815.YPO0158 CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_459690_1 391615.ABSJ01000054_gene1465 6.7e-79 248.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1J4NS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_101016_1 672.VV93_v1c31100 8.47e-57 195.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria,1XY40@135623|Vibrionales 135623|Vibrionales P Na+/Pi-cotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_147836_2 671143.DAMO_1983 1.92e-77 242.0 COG1108@1|root,COG1108@2|Bacteria,2NQ6F@2323|unclassified Bacteria 2|Bacteria U ABC 3 transport family znuB - - ko:K02075,ko:K09816 ko02010,map02010 M00242,M00244 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_248742_1 1123229.AUBC01000014_gene2958 2.35e-112 331.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria,3JQPQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O prohibitin homologues - - - - - - - - - - - - Band_7 k59_1340148_1 1123400.KB904780_gene1764 5.07e-97 291.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,4604F@72273|Thiotrichales 72273|Thiotrichales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_461219_1 887898.HMPREF0551_1430 1.24e-24 102.0 COG0028@1|root,COG0028@2|Bacteria,1MWUB@1224|Proteobacteria,2VMC1@28216|Betaproteobacteria,1K2XV@119060|Burkholderiaceae 28216|Betaproteobacteria EH Belongs to the TPP enzyme family xsc - 2.3.3.15 ko:K03852 ko00430,map00430 - R05651 RC02903,RC02909 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_355928_1 999541.bgla_1g34750 6.8e-71 238.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,1K1J9@119060|Burkholderiaceae 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_521639_1 644801.Psest_3427 2.2e-105 320.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,1RQVT@1236|Gammaproteobacteria,1Z1TJ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_1139305_1 1207063.P24_07226 9.08e-75 236.0 COG1638@1|root,COG1638@2|Bacteria,1PG0D@1224|Proteobacteria,2TTUQ@28211|Alphaproteobacteria,2JVS5@204441|Rhodospirillales 204441|Rhodospirillales G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_1395530_1 1589733.A0A0C5AIN0_9CAUD 1.58e-55 181.0 4QGVD@10239|Viruses,4QSSC@28883|Caudovirales,4QK2F@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1340172_1 330214.NIDE1159 1.67e-72 224.0 COG4191@1|root,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - DUF4041,GGDEF,HATPase_c,HisKA,Response_reg,T5orf172,dCache_1 k59_1668523_2 444860.E3SIV3_9CAUD 4.66e-31 111.0 4QGXP@10239|Viruses,4QYPM@35237|dsDNA viruses no RNA stage,4QRN0@28883|Caudovirales,4QIDG@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_192842_1 330214.NIDE2829 1.3e-20 86.3 COG2165@1|root,COG2165@2|Bacteria 2|Bacteria NU general secretion pathway protein pulG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_1248286_1 1335757.SPICUR_00285 1.78e-51 182.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_8 k59_771506_1 584708.Apau_1498 4.92e-13 72.8 COG1352@1|root,COG1352@2|Bacteria,3TAGJ@508458|Synergistetes 508458|Synergistetes NT CheR methyltransferase, SAM binding domain - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_19523_1 366602.Caul_5303 1.72e-77 242.0 COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2TSWA@28211|Alphaproteobacteria,2KF1F@204458|Caulobacterales 204458|Caulobacterales E Converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH tdh - 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_408016_1 387093.SUN_0498 1.39e-23 97.4 COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,42TET@68525|delta/epsilon subdivisions,2YPK6@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Sulfur oxidation protein SoxY - - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY k59_1396809_1 269799.Gmet_1019 5.21e-16 80.5 COG2010@1|root,COG2010@2|Bacteria,1MYNE@1224|Proteobacteria,430XI@68525|delta/epsilon subdivisions,2WVWH@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrom_C k59_1185135_1 313596.RB2501_12302 3.23e-74 243.0 COG2091@1|root,COG2091@2|Bacteria,4NGXG@976|Bacteroidetes,1HZ27@117743|Flavobacteriia 976|Bacteroidetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 k59_1605287_1 1229909.NSED_02855 4.8e-29 107.0 COG1146@1|root,arCOG04548@2157|Archaea,41SI0@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4 k59_1605287_2 1229909.NSED_01105 2.04e-37 130.0 COG1146@1|root,arCOG04548@2157|Archaea,41SI0@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4 k59_876757_1 530564.Psta_3779 6.92e-25 104.0 COG1914@1|root,COG1914@2|Bacteria,2IWTS@203682|Planctomycetes 203682|Planctomycetes P COG1914 Mn2 and Fe2 transporters of the NRAMP family - - - - - - - - - - - - Nramp k59_305395_1 1197906.CAJQ02000027_gene1548 3.46e-88 287.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,3JRIE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_563065_1 330214.NIDE0426 1.15e-32 125.0 COG0539@1|root,COG1185@1|root,COG0539@2|Bacteria,COG1185@2|Bacteria,3J0CA@40117|Nitrospirae 40117|Nitrospirae J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_932491_1 635013.TherJR_1325 6.63e-34 133.0 COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia,2612J@186807|Peptococcaceae 186801|Clostridia P transporter of a GTP-driven Fe(2 ) uptake system feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_149114_2 441620.Mpop_3619 2.16e-30 110.0 COG3631@1|root,COG3631@2|Bacteria,1RISB@1224|Proteobacteria,2UAAK@28211|Alphaproteobacteria,1JXU2@119045|Methylobacteriaceae 28211|Alphaproteobacteria S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL k59_1141119_1 1121861.KB899962_gene3357 4e-222 624.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,2JQQ1@204441|Rhodospirillales 28211|Alphaproteobacteria L Transposase domain (DUF772) - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_1185172_1 479433.Caci_5359 1.59e-55 177.0 COG2030@1|root,COG2030@2|Bacteria,2IPFP@201174|Actinobacteria 201174|Actinobacteria I MaoC like domain - - - - - - - - - - - - MaoC_dehydratas k59_1185172_2 479433.Caci_5358 3.09e-64 202.0 COG2030@1|root,COG2030@2|Bacteria,2ICZR@201174|Actinobacteria 201174|Actinobacteria I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydrat_N k59_1185172_3 479433.Caci_5357 4.79e-136 403.0 COG1804@1|root,COG1804@2|Bacteria,2IEU2@201174|Actinobacteria 201174|Actinobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_932501_1 631362.Thi970DRAFT_04368 1.65e-82 271.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales 135613|Chromatiales C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_932501_2 1335757.SPICUR_00365 1.94e-27 111.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1WXGA@135613|Chromatiales 135613|Chromatiales C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) - - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1341447_1 1411123.JQNH01000001_gene3576 1.72e-05 45.8 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR78@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase mcd - 1.3.8.12 ko:K14448 ko00630,ko01120,ko01200,map00630,map01120,map01200 M00373 R09293 RC02483 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1341447_2 631454.N177_2618 2.45e-44 151.0 COG3476@1|root,COG3476@2|Bacteria,1MZC1@1224|Proteobacteria,2UBYB@28211|Alphaproteobacteria,1JPEQ@119043|Rhodobiaceae 28211|Alphaproteobacteria T TspO/MBR family tspO - - ko:K05770 ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166 - - - ko00000,ko00001,ko02000 9.A.24 - - TspO_MBR k59_305419_1 1449063.JMLS01000002_gene1405 2.19e-14 72.8 COG0538@1|root,COG0538@2|Bacteria,1UHPE@1239|Firmicutes,4H9US@91061|Bacilli,26T3H@186822|Paenibacillaceae 91061|Bacilli C Converts isocitrate to alpha ketoglutarate icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_305419_2 644966.Tmar_1686 8.1e-48 171.0 COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia 186801|Clostridia C aconitate hydratase acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_250163_1 67257.JODR01000014_gene5715 3.57e-16 77.4 COG0454@1|root,COG0456@2|Bacteria,2I9Y3@201174|Actinobacteria 201174|Actinobacteria K histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_7 k59_1185187_1 56780.SYN_01692 3.32e-37 136.0 COG0204@1|root,COG0204@2|Bacteria,1P3XM@1224|Proteobacteria 1224|Proteobacteria I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase k59_771583_1 1550091.JROE01000005_gene1974 5.82e-50 163.0 COG2947@1|root,COG2947@2|Bacteria,4NNQG@976|Bacteroidetes,1ISGG@117747|Sphingobacteriia 976|Bacteroidetes S EVE domain - - - - - - - - - - - - EVE k59_771583_2 1123258.AQXZ01000017_gene4327 1.48e-16 79.0 COG0778@1|root,COG0778@2|Bacteria,2GM9M@201174|Actinobacteria,4G47J@85025|Nocardiaceae 201174|Actinobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_462768_1 1348657.M622_03230 1.61e-80 258.0 COG3436@1|root,COG3436@2|Bacteria,1MYAC@1224|Proteobacteria,2VMF3@28216|Betaproteobacteria,2KXX9@206389|Rhodocyclales 206389|Rhodocyclales L Transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_722288_1 1122135.KB893166_gene2994 6.05e-63 207.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases preT - 1.3.1.1 ko:K17722 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046 R00977,R01414,R11026 RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,Pyr_redox_2 k59_1396889_1 1121360.AUAQ01000016_gene1145 7.67e-33 130.0 COG2905@1|root,COG2905@2|Bacteria,2I91C@201174|Actinobacteria,22KWJ@1653|Corynebacteriaceae 201174|Actinobacteria T signal-transduction protein containing cAMP-binding and CBS domains - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_1396889_2 1117647.M5M_01570 2.83e-16 79.0 COG0847@1|root,COG0847@2|Bacteria,1RAF1@1224|Proteobacteria,1S9PP@1236|Gammaproteobacteria,1J6J0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase III, epsilon subunit - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_876821_1 272624.lpg1713 3e-58 191.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1JCZR@118969|Legionellales 118969|Legionellales J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_305462_1 1121921.KB898707_gene1257 2.16e-32 121.0 COG3637@1|root,COG3637@2|Bacteria,1RHVI@1224|Proteobacteria,1S6UY@1236|Gammaproteobacteria,2PP0E@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl,OmpA_membrane k59_192964_1 59538.XP_005976199.1 2.05e-10 63.9 COG0107@1|root,KOG0623@2759|Eukaryota,38J63@33154|Opisthokonta 33154|Opisthokonta E imidazoleglycerol-phosphate synthase activity - - - - - - - - - - - - His_biosynth k59_192964_2 1249627.D779_0918 2.56e-41 137.0 COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,1S8UG@1236|Gammaproteobacteria,1WYZ3@135613|Chromatiales 135613|Chromatiales J Belongs to the bacterial ribosomal protein bL28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k59_1670615_1 1198232.CYCME_0402 9.49e-08 60.5 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1S3Q4@1236|Gammaproteobacteria,462VQ@72273|Thiotrichales 72273|Thiotrichales Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - - k59_1396906_1 1435356.Y013_03320 2.87e-18 87.8 COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,4FVYM@85025|Nocardiaceae 201174|Actinobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1455545_1 156889.Mmc1_0551 1.17e-113 349.0 COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria 1224|Proteobacteria C denitrification pathway cbcY - - - - - - - - - - - Cytochrom_c3_2,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese k59_149184_1 575540.Isop_0508 3e-36 140.0 COG0367@1|root,COG0367@2|Bacteria,2IXAI@203682|Planctomycetes 203682|Planctomycetes E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1341504_1 240015.ACP_1394 1.27e-10 68.9 COG3534@1|root,COG4625@1|root,COG3534@2|Bacteria,COG4625@2|Bacteria,3Y354@57723|Acidobacteria,2JKXY@204432|Acidobacteriia 204432|Acidobacteriia N Putative Ig domain - - - - - - - - - - - - He_PIG k59_192988_1 1123508.JH636444_gene5244 3.45e-63 211.0 COG0642@1|root,COG2205@2|Bacteria,2IYV4@203682|Planctomycetes 203682|Planctomycetes T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA k59_1185238_1 1453501.JELR01000002_gene677 5.15e-128 369.0 COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,1RPYV@1236|Gammaproteobacteria,464KC@72275|Alteromonadaceae 1236|Gammaproteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_1185238_2 1046724.KB889908_gene976 1.36e-05 46.6 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,4655B@72275|Alteromonadaceae 1236|Gammaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_1455569_1 1123504.JQKD01000004_gene5078 7.31e-50 174.0 COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2VJ77@28216|Betaproteobacteria,4ABI1@80864|Comamonadaceae 28216|Betaproteobacteria S MmgE PrpD family protein - - - - - - - - - - - - MmgE_PrpD k59_1185269_2 1380347.JNII01000008_gene4382 5.36e-12 66.6 COG4961@1|root,COG4961@2|Bacteria,2IS3K@201174|Actinobacteria 201174|Actinobacteria U TadE-like protein - - - - - - - - - - - - TadE k59_250252_1 472759.Nhal_3456 1.65e-45 153.0 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,1WWJC@135613|Chromatiales 135613|Chromatiales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_250252_2 1283300.ATXB01000001_gene328 1.91e-71 218.0 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,1XF5B@135618|Methylococcales 135618|Methylococcales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_104106_1 1504981.KO116_0381 1.99e-38 138.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1XIP5@135619|Oceanospirillales 135619|Oceanospirillales J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_104106_2 314287.GB2207_08831 5.52e-24 94.7 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1J5V6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_615125_1 1207063.P24_02666 7.68e-17 87.8 COG0576@1|root,COG3941@1|root,COG0576@2|Bacteria,COG3941@2|Bacteria 2|Bacteria O tape measure - - 3.4.21.102 ko:K03561,ko:K03687,ko:K03797 - - - - ko00000,ko01000,ko01002,ko02000,ko03029,ko03110 1.A.30.2.1 - - GrpE,HTH_26 k59_193036_2 395961.Cyan7425_1640 1.46e-12 67.8 COG1595@1|root,COG1595@2|Bacteria,1G0QM@1117|Cyanobacteria,3KHB8@43988|Cyanothece 1117|Cyanobacteria K Belongs to the sigma-70 factor family. ECF subfamily sigG - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1088959_1 247490.KSU1_C1324 8.99e-11 68.2 COG1957@1|root,COG3055@1|root,COG3204@1|root,COG4932@1|root,COG1957@2|Bacteria,COG3055@2|Bacteria,COG3204@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - - ko:K02674,ko:K07004 - - - - ko00000,ko02035,ko02044 - - - DUF547,Laminin_G_3,Malectin k59_722374_1 1304275.C41B8_11553 1.79e-72 233.0 COG3425@1|root,COG3425@2|Bacteria,1MU4K@1224|Proteobacteria,1S16F@1236|Gammaproteobacteria 1236|Gammaproteobacteria I synthase - - 2.3.3.10 ko:K01641,ko:K15311 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130 M00088,M00095 R01978 RC00004,RC00503 ko00000,ko00001,ko00002,ko01000,ko01008 - - - HMG_CoA_synt_C,HMG_CoA_synt_N k59_566114_1 290318.Cvib_0035 5.12e-12 63.2 COG0607@1|root,COG0607@2|Bacteria,1FEK7@1090|Chlorobi 1090|Chlorobi P PFAM Rhodanese domain protein - - - - - - - - - - - - Rhodanese k59_566114_2 713587.THITH_04055 1.37e-26 101.0 COG2932@1|root,COG2932@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - ko:K09384 - - - - ko00000 - - - DUF3427,HIT,HTH_31,Helicase_C,Methyltransf_25,PLDc_2,Peptidase_S24,ResIII k59_566114_3 713587.THITH_00405 6.14e-39 138.0 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,1WWHP@135613|Chromatiales 135613|Chromatiales M PFAM NAD-dependent epimerase dehydratase - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_774349_1 671143.DAMO_2847 5.14e-86 263.0 COG0180@1|root,COG0180@2|Bacteria,2NNQX@2323|unclassified Bacteria 2|Bacteria J tRNA synthetases class I (W and Y) trpS GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_726595_2 1229909.NSED_03375 1.02e-27 110.0 COG0008@1|root,arCOG00402@2157|Archaea,41SFI@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b k59_1147386_1 1380390.JIAT01000009_gene1094 1.11e-68 225.0 COG2040@1|root,COG2264@1|root,COG2040@2|Bacteria,COG2264@2|Bacteria,2HQK7@201174|Actinobacteria,4CS5N@84995|Rubrobacteria 84995|Rubrobacteria EJ Homocysteine S-methyltransferase - - - - - - - - - - - - PrmA,S-methyl_trans k59_775690_1 388051.AUFE01000014_gene6032 5.19e-14 75.1 COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,2VN5I@28216|Betaproteobacteria,1K1GQ@119060|Burkholderiaceae 28216|Betaproteobacteria C Part of a membrane complex involved in electron transport rnfB - - ko:K03616 - - - - ko00000 - - - FeS,Fer4_21 k59_775690_2 1335757.SPICUR_02565 4.46e-11 61.2 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1WW35@135613|Chromatiales 135613|Chromatiales L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_1253612_1 448385.sce1432 1.12e-49 180.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions 1224|Proteobacteria K PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - GAF_2,HTH_8,Pkinase,Sigma54_activat k59_468043_1 314285.KT71_16541 4.24e-20 94.7 COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria,1JAEW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins zipA GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - ko:K03528 - - - - ko00000,ko03036 - - - ZipA_C k59_468043_2 1177181.T9A_01684 2.95e-31 123.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1XHFN@135619|Oceanospirillales 135619|Oceanospirillales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_1460637_2 1411123.JQNH01000001_gene2072 6.35e-192 543.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F MA20_43260 - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_154357_1 1123518.ARWI01000001_gene91 7.26e-89 272.0 COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,1RQ6Z@1236|Gammaproteobacteria,45ZXT@72273|Thiotrichales 72273|Thiotrichales P PFAM Bacterial extracellular solute-binding protein - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6,SBP_bac_8 k59_1190474_1 1121918.ARWE01000001_gene964 1.64e-14 77.4 COG1638@1|root,COG1638@2|Bacteria,1PJFW@1224|Proteobacteria,42PXK@68525|delta/epsilon subdivisions,2WJFU@28221|Deltaproteobacteria 28221|Deltaproteobacteria G PFAM TRAP dicarboxylate transporter- DctP subunit - - - - - - - - - - - - DctP k59_984379_1 96561.Dole_0797 3.77e-53 173.0 COG3216@1|root,COG3216@2|Bacteria,1N1Q6@1224|Proteobacteria,42VQP@68525|delta/epsilon subdivisions,2WRUZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2062) - - - - - - - - - - - - DUF2062 k59_984379_2 983545.Glaag_3833 0.00017 44.3 COG2982@1|root,COG2982@2|Bacteria,1P6EN@1224|Proteobacteria,1S1EC@1236|Gammaproteobacteria,4666J@72275|Alteromonadaceae 1236|Gammaproteobacteria M Protein involved in outer membrane biogenesis - - - - - - - - - - - - DUF748 k59_310482_1 754476.Q7A_1149 3.9e-51 177.0 COG1538@1|root,COG1538@2|Bacteria,1MYX2@1224|Proteobacteria,1RNX1@1236|Gammaproteobacteria,4608N@72273|Thiotrichales 72273|Thiotrichales MU TIGRFAM type I secretion outer membrane protein, TolC family - - - ko:K12543 - M00330 - - ko00000,ko00002,ko02000,ko02044 1.B.17,3.A.1.109.4 - - OEP k59_310482_2 1131553.JIBI01000004_gene425 5.84e-10 59.3 COG2197@1|root,COG2197@2|Bacteria,1N8MU@1224|Proteobacteria,2VV2P@28216|Betaproteobacteria,372VT@32003|Nitrosomonadales 28216|Betaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_1346715_1 1128421.JAGA01000002_gene850 1.43e-52 183.0 COG3044@1|root,COG3044@2|Bacteria,2NNSZ@2323|unclassified Bacteria 2|Bacteria S Predicted ATPase of the ABC class - - - - - - - - - - - - ABC_ATPase k59_198715_1 58344.JOEL01000083_gene2440 6.89e-75 235.0 COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria 201174|Actinobacteria F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism add1 GO:0000034,GO:0003674,GO:0003824,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase k59_726649_1 105559.Nwat_0871 3.78e-58 192.0 COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,1SKJ8@1236|Gammaproteobacteria,1X0FH@135613|Chromatiales 135613|Chromatiales F Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C k59_620790_1 251221.35210757 4.61e-76 252.0 COG1501@1|root,COG1501@2|Bacteria,1G3UD@1117|Cyanobacteria 1117|Cyanobacteria G Belongs to the glycosyl hydrolase 31 family - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31 k59_310527_1 314285.KT71_04550 6.78e-08 59.3 2EMUX@1|root,33FH7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1460701_1 1122609.AUGT01000024_gene383 2.23e-72 227.0 COG2141@1|root,COG2141@2|Bacteria,2GJT1@201174|Actinobacteria 201174|Actinobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_1147474_1 886293.Sinac_7397 1.1e-19 88.6 COG1861@1|root,COG1861@2|Bacteria,2J3F7@203682|Planctomycetes 203682|Planctomycetes M PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_4 k59_1460716_1 330214.NIDE4159 8.75e-56 177.0 2E4SV@1|root,32ZM7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - PGPGW k59_984457_2 1038859.AXAU01000028_gene29 9.24e-17 77.8 2BGXJ@1|root,32AXJ@2|Bacteria,1NHJS@1224|Proteobacteria,2UN1Q@28211|Alphaproteobacteria,3K4PM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1553217_1 1054213.HMPREF9946_01325 4.58e-78 242.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,2JQ95@204441|Rhodospirillales 204441|Rhodospirillales E Methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_468123_1 1121403.AUCV01000004_gene2012 1.39e-76 250.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42NDG@68525|delta/epsilon subdivisions,2WKYU@28221|Deltaproteobacteria,2MISU@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1402128_1 69042.WH5701_04885 1e-09 64.7 COG0664@1|root,COG0668@1|root,COG0664@2|Bacteria,COG0668@2|Bacteria,1G1QG@1117|Cyanobacteria,1GYCP@1129|Synechococcus 1117|Cyanobacteria MT mechanosensitive - - - - - - - - - - - - MS_channel,cNMP_binding k59_984463_1 1229909.NSED_02125 4.4e-68 216.0 COG0517@1|root,arCOG00601@2157|Archaea 2157|Archaea C CBS domain - - - - - - - - - - - - - k59_198786_1 1411123.JQNH01000001_gene37 3.93e-76 239.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2TRIQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the DegT DnrJ EryC1 family MA20_07980 - - - - - - - - - - - DegT_DnrJ_EryC1 k59_1346799_1 404380.Gbem_0514 5.85e-26 106.0 COG0501@1|root,COG0501@2|Bacteria,1NK9F@1224|Proteobacteria,42TCQ@68525|delta/epsilon subdivisions,2WM2D@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM peptidase M48 Ste24p - - - - - - - - - - - - Peptidase_M48 k59_362348_1 1229909.NSED_03180 1.01e-85 275.0 COG3889@1|root,arCOG01672@2157|Archaea,41SA5@651137|Thaumarchaeota 651137|Thaumarchaeota S Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1460740_1 485915.Dret_0865 3.37e-10 60.1 2EDD9@1|root,3379K@2|Bacteria,1NKEJ@1224|Proteobacteria,42WG9@68525|delta/epsilon subdivisions,2WSF6@28221|Deltaproteobacteria,2MD85@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF3568) - - - - - - - - - - - - DUF3568 k59_1460740_2 1118055.CAGU01000032_gene201 1.45e-12 67.4 COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,24876@186801|Clostridia,22G4B@1570339|Peptoniphilaceae 186801|Clostridia S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_775804_1 314285.KT71_02682 4.1e-70 226.0 COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,1T3IW@1236|Gammaproteobacteria,1J8JS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1 k59_254675_1 1163617.SCD_n00430 1.04e-80 251.0 COG0826@1|root,COG0826@2|Bacteria,1MWFW@1224|Proteobacteria,2VISF@28216|Betaproteobacteria 28216|Betaproteobacteria O Peptidase U32 - - - - - - - - - - - - Peptidase_U32 k59_1346812_1 556268.OFAG_01295 3.45e-16 83.6 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,4726Y@75682|Oxalobacteraceae 28216|Betaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_881211_1 1388763.O165_015120 4.07e-48 168.0 COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria,1YVPD@136845|Pseudomonas putida group 1236|Gammaproteobacteria L Winged helix-turn helix - - - ko:K07497 - - - - ko00000 - - - HTH_32,LZ_Tnp_IS481,rve,rve_3 k59_984497_1 1198232.CYCME_0186 3.73e-43 147.0 COG3663@1|root,COG3663@2|Bacteria,1RAVZ@1224|Proteobacteria,1S2GN@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells mug - 3.2.2.28 ko:K03649 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_984497_2 1282362.AEAC466_09495 1.03e-19 87.4 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2TQN1@28211|Alphaproteobacteria,2KFJ5@204458|Caulobacterales 204458|Caulobacterales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane - - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_1094165_1 224911.27354189 3.22e-73 234.0 COG0112@1|root,COG0112@2|Bacteria,1R3T8@1224|Proteobacteria,2U2N3@28211|Alphaproteobacteria,3JT5C@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism - - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_567644_1 35128.Thapsdraft2050 7.08e-96 311.0 COG0086@1|root,2RUNH@2759|Eukaryota,2XF5V@2836|Bacillariophyta 2836|Bacillariophyta H DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC2 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1609254_1 1122185.N792_08015 1.85e-210 614.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_362384_1 1340493.JNIF01000004_gene563 8.42e-38 138.0 COG0448@1|root,COG0448@2|Bacteria,3Y35M@57723|Acidobacteria 57723|Acidobacteria G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans - - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_881229_1 875328.JDM601_0544 7.07e-51 173.0 COG1073@1|root,COG1073@2|Bacteria,2I8SP@201174|Actinobacteria,234F7@1762|Mycobacteriaceae 201174|Actinobacteria S alpha beta - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - - k59_984519_1 1304874.JAFY01000002_gene333 7.49e-56 191.0 COG3131@1|root,COG3131@2|Bacteria,3TAJ8@508458|Synergistetes 508458|Synergistetes P periplasmic glucan biosynthesis protein - - - ko:K03670 - - - - ko00000 - - - MdoG k59_468167_1 1232410.KI421425_gene1564 6.27e-123 365.0 COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42PIE@68525|delta/epsilon subdivisions,2WM3C@28221|Deltaproteobacteria,43SBI@69541|Desulfuromonadales 28221|Deltaproteobacteria C Polysulphide reductase, NrfD moz - - ko:K00185 - - - - ko00000 5.A.3 - - DUF3341,NrfD k59_567659_1 1379698.RBG1_1C00001G0855 4.46e-38 147.0 COG0243@1|root,COG0243@2|Bacteria,2NPRJ@2323|unclassified Bacteria 2|Bacteria C Molydopterin dinucleotide binding domain qrcB - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1147583_1 1380355.JNIJ01000053_gene2150 1.38e-53 185.0 COG0179@1|root,COG1893@1|root,COG0179@2|Bacteria,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid panE - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C,DUF2437,FAA_hydrolase k59_1147583_2 717785.HYPMC_4899 1.13e-05 46.6 COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,3N8VS@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria H Ketopantoate reductase PanE/ApbA C terminal panE - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C,DUF2437,FAA_hydrolase k59_198860_1 313596.RB2501_05390 9.05e-19 91.3 COG1524@1|root,COG1524@2|Bacteria,4NE94@976|Bacteroidetes,1HZW3@117743|Flavobacteriia 976|Bacteroidetes S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_984545_1 330214.NIDE2440 1.71e-55 195.0 COG0667@1|root,COG1331@1|root,COG0667@2|Bacteria,COG1331@2|Bacteria,3J0HX@40117|Nitrospirae 40117|Nitrospirae O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_1553297_1 1333998.M2A_2034 1.57e-86 267.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria,4BPRD@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1190650_1 1122139.KB907868_gene1236 7.07e-18 88.2 COG1063@1|root,COG1063@2|Bacteria,1RB8K@1224|Proteobacteria,1SMWN@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_881269_1 335543.Sfum_0899 8.25e-79 255.0 COG0490@1|root,COG0569@1|root,COG1226@1|root,COG0490@2|Bacteria,COG0569@2|Bacteria,COG1226@2|Bacteria,1R4J8@1224|Proteobacteria,42NKU@68525|delta/epsilon subdivisions,2WIRH@28221|Deltaproteobacteria,2MRD0@213462|Syntrophobacterales 28221|Deltaproteobacteria P Ion channel - - - - - - - - - - - - Ion_trans_2,TrkA_C,TrkA_N k59_362436_1 583355.Caka_2687 4.47e-06 48.1 COG0715@1|root,COG0715@2|Bacteria 2|Bacteria P thiamine-containing compound biosynthetic process - - - - - - - - - - - - NMT1 k59_775876_1 1121403.AUCV01000020_gene3109 2.47e-50 180.0 COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein hdrA - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Fer4_7,Pyr_redox_2 k59_362448_1 436308.Nmar_0460 6.62e-21 93.6 COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota 651137|Thaumarchaeota T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,dCache_1 k59_362448_2 1229909.NSED_08765 7.98e-23 94.7 COG0640@1|root,arCOG03067@2157|Archaea 2157|Archaea K transcriptional regulators - - - - - - - - - - - - HTH_20 k59_198904_1 765912.Thimo_0051 1.07e-09 62.8 COG3166@1|root,COG3166@2|Bacteria,1RJTG@1224|Proteobacteria,1S6RT@1236|Gammaproteobacteria,1WXKF@135613|Chromatiales 135613|Chromatiales NU fimbrial assembly - - - ko:K02461 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - PilM_2,PilN k59_775890_1 1380355.JNIJ01000050_gene132 5.08e-105 310.0 COG0411@1|root,COG0411@2|Bacteria,1R5MA@1224|Proteobacteria,2TV7Q@28211|Alphaproteobacteria,3JZDF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E ATPases associated with a variety of cellular activities - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_468221_1 1202768.JROF01000021_gene3484 2.14e-07 55.5 COG2234@1|root,arCOG02959@2157|Archaea,2XU4X@28890|Euryarchaeota,23T0D@183963|Halobacteria 183963|Halobacteria S Peptidase M28 - - - - - - - - - - - - PA,Peptidase_M28 k59_1147645_1 653733.Selin_1022 6.27e-12 69.7 COG1560@1|root,COG1560@2|Bacteria 2|Bacteria M Kdo2-lipid A biosynthetic process htrB - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_1037698_1 765911.Thivi_4083 1.04e-68 226.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1WX02@135613|Chromatiales 135613|Chromatiales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_1402279_1 1096930.L284_20790 0.000824 47.0 COG0656@1|root,COG0656@2|Bacteria,1MWFS@1224|Proteobacteria,2TT2Q@28211|Alphaproteobacteria,2K0PQ@204457|Sphingomonadales 204457|Sphingomonadales S Aldo keto - - 1.1.1.346 ko:K06221 - - R08878 RC00089 ko00000,ko01000 - - - Aldo_ket_red k59_198925_1 373994.Riv7116_5082 1.23e-77 260.0 COG1506@1|root,COG1506@2|Bacteria,1G4RA@1117|Cyanobacteria,1HR6J@1161|Nostocales 1117|Cyanobacteria E PFAM Prolyl oligopeptidase family - - - - - - - - - - - - Peptidase_S9 k59_567742_1 291985.CCSI01000004_gene616 8.7e-14 73.6 COG0654@1|root,COG0654@2|Bacteria,1NSGN@1224|Proteobacteria,2UPGQ@28211|Alphaproteobacteria,2KEGZ@204457|Sphingomonadales 204457|Sphingomonadales CH Tryptophan halogenase - - 1.14.19.9 ko:K14266 ko00404,ko01130,map00404,map01130 M00789,M00790 R09570 RC00949 ko00000,ko00001,ko00002,ko01000 - - - Trp_halogenase k59_567742_2 493475.GARC_2824 2.46e-46 156.0 COG1262@1|root,COG1262@2|Bacteria,1RB2U@1224|Proteobacteria,1T3VJ@1236|Gammaproteobacteria,46D8U@72275|Alteromonadaceae 1236|Gammaproteobacteria S SapC - - - - - - - - - - - - SapC k59_986736_1 1049564.TevJSym_ad00780 5e-92 287.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1J4HN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360 - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_22673_1 314264.ROS217_00500 3.65e-07 57.8 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,46RSG@74030|Roseovarius 28211|Alphaproteobacteria I Biotin carboxylase C-terminal domain - - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_156454_1 344747.PM8797T_17614 8.38e-67 222.0 COG0442@1|root,COG0442@2|Bacteria,2IX8V@203682|Planctomycetes 203682|Planctomycetes J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b,tRNA_edit k59_729938_1 2340.JV46_14290 9.81e-75 242.0 COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit - - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_625630_1 247634.GPB2148_3359 6.37e-46 159.0 2DMXI@1|root,32U9G@2|Bacteria,1NFAA@1224|Proteobacteria,1SRGT@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_625630_2 1324957.K933_09002 7.66e-21 92.0 COG0733@1|root,arCOG04466@2157|Archaea,2XTG1@28890|Euryarchaeota,23SDV@183963|Halobacteria 183963|Halobacteria P COG0733 Na -dependent transporters of the SNF family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_203569_1 1121861.KB899918_gene3217 2e-64 205.0 COG1951@1|root,COG1951@2|Bacteria,1MW8J@1224|Proteobacteria,2U0X2@28211|Alphaproteobacteria,2JWAC@204441|Rhodospirillales 204441|Rhodospirillales C Fumarate hydratase (Fumerase) - - - - - - - - - - - - Fumerase k59_1195123_2 1047013.AQSP01000084_gene767 4.38e-41 148.0 COG1145@1|root,COG1456@1|root,COG1145@2|Bacteria,COG1456@2|Bacteria 2|Bacteria C acetyl-CoA catabolic process acsC - 1.3.1.1,1.3.98.1,2.1.1.245 ko:K00197,ko:K00226,ko:K08941,ko:K17723 ko00240,ko00410,ko00680,ko00720,ko00770,ko01100,ko01120,ko01200,map00240,map00410,map00680,map00720,map00770,map01100,map01120,map01200 M00046,M00051,M00357,M00377,M00422,M00598 R00977,R01414,R01867,R09096,R10219,R10243,R11026 RC00004,RC00051,RC00072,RC00113,RC00123,RC02977 ko00000,ko00001,ko00002,ko00194,ko01000 - - - CdhD,DHO_dh,FeS,Fer4 k59_1558081_1 488538.SAR116_1458 3.83e-13 70.1 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2VFEC@28211|Alphaproteobacteria,4BQWR@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1558081_2 316274.Haur_1095 1.38e-10 63.5 COG0405@1|root,COG0405@2|Bacteria,2G5R2@200795|Chloroflexi,374X4@32061|Chloroflexia 32061|Chloroflexia E PFAM gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1612276_1 107636.JQNK01000009_gene3036 1.18e-71 222.0 COG0265@1|root,COG0265@2|Bacteria,1R40X@1224|Proteobacteria,2U5RD@28211|Alphaproteobacteria,36ZMC@31993|Methylocystaceae 28211|Alphaproteobacteria O Trypsin-like peptidase domain - - - - - - - - - - - - Trypsin_2 k59_1558093_1 178306.PAE0949 1.57e-16 83.2 COG0309@1|root,arCOG00636@2157|Archaea,2XQ72@28889|Crenarchaeota 28889|Crenarchaeota O AIR synthase related protein domain protein hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_625672_1 1231190.NA8A_00960 6.28e-48 171.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_570934_1 330214.NIDE1310 1.23e-57 179.0 COG0051@1|root,COG0051@2|Bacteria,3J0P3@40117|Nitrospirae 40117|Nitrospirae J Involved in the binding of tRNA to the ribosomes rpsJ - - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_570934_2 243230.DR_2050 3.59e-19 85.9 COG0050@1|root,COG0050@2|Bacteria,1WI4Y@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_729985_1 566466.NOR53_1390 5.41e-92 283.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1J7ES@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G MFS/sugar transport protein ynaJ - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_1351389_2 330214.NIDE1670 6.41e-24 101.0 COG1092@1|root,COG1092@2|Bacteria,3J0IV@40117|Nitrospirae 40117|Nitrospirae J S-adenosylmethionine-dependent methyltransferase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_729995_1 998674.ATTE01000001_gene2788 1.24e-49 171.0 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,460JH@72273|Thiotrichales 72273|Thiotrichales O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_1195185_1 290397.Adeh_1068 6.5e-19 85.1 COG2220@1|root,COG2220@2|Bacteria,1MUY6@1224|Proteobacteria,42Q5T@68525|delta/epsilon subdivisions,2WUTJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_3 k59_1195185_2 1340493.JNIF01000003_gene2958 4.68e-07 52.8 COG2605@1|root,COG2605@2|Bacteria,3Y56A@57723|Acidobacteria 57723|Acidobacteria S GHMP kinases N terminal domain - - 2.7.1.168 ko:K07031 ko00540,map00540 - R09770 RC00002,RC00078 ko00000,ko00001,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_1040746_2 935863.AWZR01000003_gene2701 3.19e-14 73.2 COG0017@1|root,COG0017@2|Bacteria,1MWFV@1224|Proteobacteria,1RMU4@1236|Gammaproteobacteria,1X3ZM@135614|Xanthomonadales 135614|Xanthomonadales J asparaginyl-tRNA synthetase asnS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_257965_2 706587.Desti_3081 3.05e-43 152.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2WJB0@28221|Deltaproteobacteria,2MQ5Y@213462|Syntrophobacterales 28221|Deltaproteobacteria F Belongs to the argininosuccinate synthase family. Type 1 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_625727_1 713586.KB900536_gene572 2.63e-27 104.0 COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,1S2XX@1236|Gammaproteobacteria,1WY2K@135613|Chromatiales 135613|Chromatiales S TIGRFAM Polyhydroxyalkanoate synthesis repressor PhaR - - - - - - - - - - - - PHB_acc,PHB_acc_N k59_625727_2 713586.KB900536_gene571 3.62e-113 332.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,1RNH2@1236|Gammaproteobacteria,1WWM8@135613|Chromatiales 135613|Chromatiales IQ TIGRFAM acetoacetyl-CoA reductase - - 1.1.1.36 ko:K00023 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R01779,R01977 RC00103,RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short_C2 k59_23433_2 1040989.AWZU01000057_gene5093 2.44e-67 213.0 COG0596@1|root,COG0596@2|Bacteria,1MUVB@1224|Proteobacteria,2TREP@28211|Alphaproteobacteria,3JWVC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Alpha/beta hydrolase family dehH - 3.8.1.3 ko:K01561 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_257982_1 266117.Rxyl_0113 1.63e-44 153.0 COG1319@1|root,COG1319@2|Bacteria,2GT14@201174|Actinobacteria,4CSQX@84995|Rubrobacteria 84995|Rubrobacteria C PFAM molybdopterin dehydrogenase, FAD-binding - - 1.2.5.3 ko:K03519 - - R11168 RC02800 ko00000,ko01000 - - - CO_deh_flav_C,FAD_binding_5 k59_1558189_1 215803.DB30_3758 1.53e-84 267.0 COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,42Q1B@68525|delta/epsilon subdivisions,2WKJH@28221|Deltaproteobacteria,2YU85@29|Myxococcales 28221|Deltaproteobacteria G FGGY family of carbohydrate kinases, N-terminal domain - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_1195226_1 1244869.H261_07813 3.28e-17 85.9 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JQXF@204441|Rhodospirillales 204441|Rhodospirillales E COG0367 Asparagine synthase (glutamine-hydrolyzing) - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_257992_1 1123392.AQWL01000008_gene1222 7.6e-19 87.8 COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,2VM4U@28216|Betaproteobacteria 28216|Betaproteobacteria S Tail sheath protein - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1,Phage_sheath_1C k59_257992_2 1336237.JAEE01000015_gene2313 1.11e-06 52.4 COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,1RMYP@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the alpha,beta-elimination reaction of D- cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine dcyD GO:0000096,GO:0000098,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006791,GO:0006807,GO:0006950,GO:0007154,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010438,GO:0016054,GO:0016829,GO:0016846,GO:0016848,GO:0019148,GO:0019149,GO:0019447,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0042594,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046416,GO:0046438,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0070279,GO:0071496,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 4.4.1.15 ko:K05396 ko00270,map00270 - R01874 RC00382 ko00000,ko00001,ko01000 - - iSFV_1184.SFV_1963,iSF_1195.SF1962,iSFxv_1172.SFxv_2191,iS_1188.S2058 PALP k59_1558220_1 1318628.MARLIPOL_17283 1.66e-10 67.8 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,46578@72275|Alteromonadaceae 1236|Gammaproteobacteria NU Tfp pilus assembly protein tip-associated adhesin pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_625803_1 243233.MCA3078 3.74e-105 315.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1T1HN@1236|Gammaproteobacteria,1XDWI@135618|Methylococcales 135618|Methylococcales V pfam abc - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1040795_1 443598.AUFA01000049_gene415 1.09e-23 105.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - AAA_16,Abhydrolase_1,DZR,Guanylate_cyc,TPR_4 k59_779049_1 765912.Thimo_2084 7.21e-88 275.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWMG@135613|Chromatiales 135613|Chromatiales L DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlB - 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C k59_1040796_1 1094980.Mpsy_0698 2.11e-76 246.0 COG0058@1|root,arCOG01421@2157|Archaea,2XV8J@28890|Euryarchaeota,2NACZ@224756|Methanomicrobia 224756|Methanomicrobia G PFAM glycosyl transferase, family 35 - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_989467_1 414684.RC1_0143 2.52e-37 135.0 COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,2TSAC@28211|Alphaproteobacteria,2JPB4@204441|Rhodospirillales 204441|Rhodospirillales I Acyl-CoA dehydrogenase, middle domain - - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_989467_2 187272.Mlg_1290 4.67e-41 141.0 28NIR@1|root,2ZBK2@2|Bacteria,1RAAF@1224|Proteobacteria,1SEVZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_730071_1 768671.ThimaDRAFT_3413 2.48e-96 301.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1WWXP@135613|Chromatiales 135613|Chromatiales J small GTP-binding protein - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_203773_1 519989.ECTPHS_12438 4.54e-101 305.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1WW7C@135613|Chromatiales 135613|Chromatiales E Belongs to the aspartokinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_23455_1 688245.CtCNB1_2026 5.18e-06 49.3 2DBBP@1|root,2Z88Z@2|Bacteria,1R3B4@1224|Proteobacteria,2VNEU@28216|Betaproteobacteria 28216|Betaproteobacteria S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3 k59_23455_2 1123269.NX02_14725 1.76e-20 92.0 2BWJ3@1|root,2Z8E8@2|Bacteria,1QZVQ@1224|Proteobacteria,2TYF6@28211|Alphaproteobacteria,2KEMF@204457|Sphingomonadales 204457|Sphingomonadales S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_625849_1 1123253.AUBD01000014_gene874 2.52e-43 156.0 COG0642@1|root,COG0642@2|Bacteria,1R54G@1224|Proteobacteria,1RWXF@1236|Gammaproteobacteria,1X4MP@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k59_1558284_1 472759.Nhal_3586 1.79e-118 357.0 COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,1X0IX@135613|Chromatiales 135613|Chromatiales S PFAM peptidase S15 - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_625865_2 388467.A19Y_2793 1.91e-68 220.0 COG3621@1|root,COG3621@2|Bacteria,1G2Q1@1117|Cyanobacteria,1H9V8@1150|Oscillatoriales 1117|Cyanobacteria S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_1558325_1 103690.17134370 7.21e-11 66.6 COG2227@1|root,COG2227@2|Bacteria,1G8EV@1117|Cyanobacteria 1117|Cyanobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_884495_1 1286171.EAL2_c09730 5.22e-16 83.2 COG0661@1|root,COG0661@2|Bacteria,1TPIV@1239|Firmicutes,2494Y@186801|Clostridia,25UQJ@186806|Eubacteriaceae 186801|Clostridia S ABC1 family ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_1558367_1 440512.C211_15425 1.68e-68 221.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria 1236|Gammaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_625934_2 1380391.JIAS01000015_gene126 4.3e-10 63.2 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,2JYIB@204441|Rhodospirillales 204441|Rhodospirillales Q Dienelactone hydrolase family - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_779123_1 330214.NIDE1208 8.61e-33 116.0 COG2331@1|root,COG2331@2|Bacteria 2|Bacteria P Regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 k59_730160_2 290397.Adeh_2654 1.72e-17 84.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WQC6@28221|Deltaproteobacteria,2YV64@29|Myxococcales 28221|Deltaproteobacteria EH Aminotransferase - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_203909_1 1382304.JNIL01000001_gene671 6.34e-41 145.0 COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,4HCDR@91061|Bacilli,278DG@186823|Alicyclobacillaceae 91061|Bacilli T Protein phosphatase 2C stp - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_1558414_1 1499686.BN1079_02999 1.17e-99 299.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria 1236|Gammaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_571149_1 1030157.AFMP01000015_gene3471 2.27e-07 57.4 COG5361@1|root,COG5361@2|Bacteria,1PF7H@1224|Proteobacteria,2U4QR@28211|Alphaproteobacteria,2K9E9@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF1214) - - - - - - - - - - - - DUF1214 k59_203942_1 312153.Pnuc_2018 5.66e-26 105.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2VI3A@28216|Betaproteobacteria,1K1TI@119060|Burkholderiaceae 28216|Betaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_1040885_1 42565.FP66_15480 3e-38 133.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,1S21E@1236|Gammaproteobacteria,1XJ5T@135619|Oceanospirillales 135619|Oceanospirillales H May be involved in the biosynthesis of molybdopterin moaB - 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_1558458_1 1229909.NSED_00725 2.85e-88 270.0 COG0546@1|root,arCOG04692@2157|Archaea,41SJ6@651137|Thaumarchaeota 651137|Thaumarchaeota S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2,Hydrolase k59_258168_1 572477.Alvin_1834 7.05e-47 157.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,1RN1J@1236|Gammaproteobacteria,1WWMS@135613|Chromatiales 135613|Chromatiales I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k59_203989_1 933262.AXAM01000008_gene1934 7.04e-69 220.0 COG1899@1|root,COG1899@2|Bacteria,1R3WQ@1224|Proteobacteria,42M57@68525|delta/epsilon subdivisions,2WJ6N@28221|Deltaproteobacteria,2MHW7@213118|Desulfobacterales 28221|Deltaproteobacteria O peptidyl-lysine modification to peptidyl-hypusine - - - - - - - - - - - - - k59_1351679_1 1384054.N790_03180 6.07e-15 77.4 COG0154@1|root,COG3391@1|root,COG0154@2|Bacteria,COG3391@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1X4K6@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia gatAX - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase,Lipocalin_5 k59_1351679_2 1336208.JADY01000004_gene3504 9.12e-14 70.9 COG1234@1|root,COG1234@2|Bacteria,1Q4PW@1224|Proteobacteria,2U2XG@28211|Alphaproteobacteria,2JWAH@204441|Rhodospirillales 204441|Rhodospirillales J Beta-lactamase superfamily domain - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_1558505_1 519989.ECTPHS_00465 7.26e-17 73.2 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,1S8R8@1236|Gammaproteobacteria,1WYXU@135613|Chromatiales 135613|Chromatiales J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_1558505_2 1335757.SPICUR_02840 9.3e-31 113.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,1S5VU@1236|Gammaproteobacteria,1WYA2@135613|Chromatiales 135613|Chromatiales J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_571219_1 445686.E3SL64_9CAUD 4.21e-89 267.0 4QAWI@10239|Viruses,4QW40@35237|dsDNA viruses no RNA stage,4QPUX@28883|Caudovirales,4QINW@10662|Myoviridae 10662|Myoviridae S Pfam:Peptidase_S77 - - - - - - - - - - - - - k59_626114_1 404589.Anae109_3715 1.48e-185 531.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2YUQN@29|Myxococcales 28221|Deltaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1406983_1 459495.SPLC1_S102320 1.56e-41 148.0 COG1085@1|root,COG1085@2|Bacteria,1G1CA@1117|Cyanobacteria,1H82Z@1150|Oscillatoriales 1117|Cyanobacteria C galactose-1-phosphate - - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GalP_UDP_tr_C,GalP_UDP_transf,HIT k59_1351722_1 522373.Smlt1504 3.11e-58 187.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1X4J2@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_1614112_2 1144932.ATTF01000023_gene795 4.01e-139 412.0 COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,2TQP6@28211|Alphaproteobacteria,4BP8J@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S PFAM FAD binding domain of DNA photolyase phrB GO:0000166,GO:0000719,GO:0003674,GO:0003824,GO:0003913,GO:0003914,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0033554,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0071949,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363 - ko:K06876 - - - - ko00000 - - - DPRP,FAD_binding_7 k59_1354086_1 1118235.CAJH01000013_gene792 9.42e-77 235.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,1X3D9@135614|Xanthomonadales 135614|Xanthomonadales C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family sdhB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_17 k59_38794_1 1144319.PMI16_01128 1.72e-13 70.1 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2VH0V@28216|Betaproteobacteria,473GX@75682|Oxalobacteraceae 28216|Betaproteobacteria KL HELICc2 dinG - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,ResIII k59_38794_2 102125.Xen7305DRAFT_00006670 1.46e-71 222.0 COG4122@1|root,COG4122@2|Bacteria,1G2Y6@1117|Cyanobacteria,3VJ94@52604|Pleurocapsales 1117|Cyanobacteria S PFAM O-methyltransferase - - 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_3 k59_38828_1 1469245.JFBG01000006_gene1600 1.04e-06 49.7 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1WXJR@135613|Chromatiales 135613|Chromatiales G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_38828_2 1109445.AGSX01000167_gene3244 9.65e-57 195.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1Z02Z@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L May be involved in recombinational repair of damaged DNA recN GO:0000724,GO:0000725,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_38912_1 1448389.BAVQ01000002_gene2942 6.21e-46 172.0 COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria 201174|Actinobacteria Q FAD dependent oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_39011_1 1215092.PA6_016_00520 4.47e-46 162.0 COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,1S0UK@1236|Gammaproteobacteria,1YE3V@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Putative aminopeptidase - - - - - - - - - - - - Aminopep k59_39100_1 634177.GLX_12450 2.71e-10 63.9 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria,2JQAZ@204441|Rhodospirillales 204441|Rhodospirillales J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_39131_1 588581.Cpap_3466 2.65e-31 127.0 COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia,3WGIX@541000|Ruminococcaceae 186801|Clostridia P transporter of a GTP-driven Fe(2 ) uptake system feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoA,FeoB_C,FeoB_N,Gate k59_39271_1 479435.Kfla_5607 3.78e-10 60.1 COG0748@1|root,COG0748@2|Bacteria,2IFYD@201174|Actinobacteria,4DRGA@85009|Propionibacteriales 201174|Actinobacteria P Pfam:DUF385 - - - - - - - - - - - - F420H2_quin_red k59_39271_2 1245475.ANAE01000164_gene2377 4.74e-23 99.0 COG0833@1|root,COG0833@2|Bacteria,2I4B6@201174|Actinobacteria,4ERAJ@85012|Streptosporangiales 201174|Actinobacteria E Amino acid permease - - - ko:K16238 - - - - ko00000,ko02000 2.A.3.5 - - AA_permease_2 k59_39275_1 1397527.Q670_10965 1.34e-32 126.0 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1XQZT@135619|Oceanospirillales 135619|Oceanospirillales PT COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - Rhodanese,cNMP_binding k59_39526_1 258533.BN977_01740 7.92e-19 92.8 COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,234PD@1762|Mycobacteriaceae 201174|Actinobacteria Q NAD(P)-binding Rossmann-like domain - - - - - - - - - - - - Amino_oxidase k59_39587_2 754476.Q7A_2409 1.56e-18 85.9 COG4726@1|root,COG4726@2|Bacteria,1N7KP@1224|Proteobacteria,1SCM5@1236|Gammaproteobacteria,4636X@72273|Thiotrichales 72273|Thiotrichales NU Type IV pilus assembly protein PilX C-term - - - ko:K02673 - - - - ko00000,ko02035,ko02044 - - - PilX,PilX_N k59_39660_1 338966.Ppro_3101 5.82e-60 208.0 COG0236@1|root,COG1028@1|root,COG3321@1|root,COG0236@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,42NGA@68525|delta/epsilon subdivisions,2WJK3@28221|Deltaproteobacteria,43W01@69541|Desulfuromonadales 28221|Deltaproteobacteria IQ PFAM Beta-ketoacyl synthase - - - - - - - - - - - - Acyl_transf_1,FabA,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_39770_1 305900.GV64_23940 1.47e-78 260.0 COG0479@1|root,COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0479@2|Bacteria,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1XNKT@135619|Oceanospirillales 135619|Oceanospirillales C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - - - - - - - - - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_39772_1 1120934.KB894424_gene1351 3.6e-16 81.6 COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4E22U@85010|Pseudonocardiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_39786_1 1121430.JMLG01000023_gene1442 1.27e-34 135.0 COG0471@1|root,COG0471@2|Bacteria,1TSP2@1239|Firmicutes,24DU3@186801|Clostridia,26769@186807|Peptococcaceae 186801|Clostridia P Similarity to COG0471 Di- and tricarboxylate transporters(Evalue - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_39811_1 1121087.AUCK01000004_gene1191 3.82e-05 47.8 COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,4HAMF@91061|Bacilli,1ZB7J@1386|Bacillus 91061|Bacilli J Methylates ribosomal protein L11 prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_39811_2 251221.35214956 4.34e-12 67.4 COG1385@1|root,COG1385@2|Bacteria,1G1VG@1117|Cyanobacteria 1117|Cyanobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_39853_1 522772.Dacet_0816 6.46e-26 104.0 COG1723@1|root,COG1723@2|Bacteria,2GGDK@200930|Deferribacteres 200930|Deferribacteres S Uncharacterised ACR, YagE family COG1723 - - - - - - - - - - - - DUF155 k59_40016_2 1335757.SPICUR_09505 1.92e-33 124.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1WY1N@135613|Chromatiales 135613|Chromatiales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_40186_1 313603.FB2170_12981 9.95e-81 247.0 COG2020@1|root,COG2020@2|Bacteria,4NJPI@976|Bacteroidetes,1I0SS@117743|Flavobacteriia,2PHZG@252356|Maribacter 976|Bacteroidetes O NnrU protein - - 2.1.1.334 ko:K21310 ko00920,map00920 - R11546 RC02653 ko00000,ko00001,ko01000 - - - NnrU k59_40202_1 1123072.AUDH01000014_gene1302 2.74e-07 57.8 2DM5E@1|root,31SVN@2|Bacteria,1MYKR@1224|Proteobacteria,2U9KT@28211|Alphaproteobacteria,2JSXH@204441|Rhodospirillales 204441|Rhodospirillales S Domain of unknown function (DUF4340) - - - - - - - - - - - - DUF4340 k59_40224_1 744979.R2A130_2662 1.04e-55 198.0 COG0845@1|root,COG1994@1|root,COG0845@2|Bacteria,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,2U0H8@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Peptidase, M50 family - - - ko:K16922 - - - - ko00000,ko01002 - - - Biotin_lipoyl_2,HlyD_3 k59_40234_1 1232410.KI421418_gene2115 4.76e-100 303.0 COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2WJ97@28221|Deltaproteobacteria,43S62@69541|Desulfuromonadales 28221|Deltaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_40292_1 391625.PPSIR1_40260 6.97e-51 184.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2YXGU@29|Myxococcales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_40355_1 512565.AMIS_61610 2.48e-07 53.9 COG0500@1|root,COG2226@2|Bacteria,2GM2N@201174|Actinobacteria,4DBMA@85008|Micromonosporales 201174|Actinobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_40381_1 765913.ThidrDRAFT_3836 5.35e-50 169.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXE7@135613|Chromatiales 135613|Chromatiales GM NAD-dependent epimerase dehydratase - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Epimerase,NAD_binding_10 k59_40526_1 1403819.BATR01000031_gene1037 2.93e-17 83.6 COG1611@1|root,COG1611@2|Bacteria,46SEG@74201|Verrucomicrobia,2ITGC@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_40526_2 28444.JODQ01000007_gene5646 4.17e-08 55.1 COG0277@1|root,COG0277@2|Bacteria,2GJ33@201174|Actinobacteria,4EFJ0@85012|Streptosporangiales 201174|Actinobacteria C D-arabinono-1,4-lactone oxidase gulO - 1.1.3.8 ko:K00103 ko00053,ko01100,map00053,map01100 M00129 R00647,R03184,R10053 RC00195,RC00346,RC00869 ko00000,ko00001,ko00002,ko01000 - - - ALO,FAD_binding_4 k59_40624_1 1392838.AWNM01000019_gene4015 6.72e-13 67.8 COG0561@1|root,COG0561@2|Bacteria,1R4WX@1224|Proteobacteria,2VI3C@28216|Betaproteobacteria,3T5DP@506|Alcaligenaceae 28216|Betaproteobacteria S hydrolases of the HAD superfamily - - - - - - - - - - - - Hydrolase_3 k59_40624_2 626418.bglu_1g14440 2.29e-50 172.0 COG3568@1|root,COG3568@2|Bacteria,1R9NP@1224|Proteobacteria,2WGEU@28216|Betaproteobacteria,1K0J8@119060|Burkholderiaceae 28216|Betaproteobacteria L endonuclease - - - - - - - - - - - - Exo_endo_phos k59_40736_1 1123248.KB893318_gene4114 3.84e-05 55.1 COG3264@1|root,COG3264@2|Bacteria,4NEAM@976|Bacteroidetes,1IPNA@117747|Sphingobacteriia 976|Bacteroidetes M mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_40844_1 1163617.SCD_n02789 5.12e-28 117.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria 28216|Betaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_2,Thioredoxin_7 k59_40876_1 583355.Caka_2646 5.48e-43 151.0 COG1131@1|root,COG1131@2|Bacteria,46SHV@74201|Verrucomicrobia,3K7SV@414999|Opitutae 414999|Opitutae V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_40927_2 1004785.AMBLS11_01220 1.53e-48 176.0 COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,1RPGN@1236|Gammaproteobacteria,465RT@72275|Alteromonadaceae 1236|Gammaproteobacteria MU COG1538 Outer membrane protein - - - - - - - - - - - - OEP k59_40963_1 1336237.JAEE01000002_gene1223 3.94e-20 84.0 COG3100@1|root,COG3100@2|Bacteria,1N83J@1224|Proteobacteria,1SCCD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S YcgL domain-containing protein ycgL - - ko:K09902 - - - - ko00000 - - - YcgL k59_40984_1 1142394.PSMK_26730 1.37e-70 222.0 COG3253@1|root,COG3253@2|Bacteria 2|Bacteria S peroxidase activity ywfI - - ko:K00435 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R11522 RC00884 ko00000,ko00001,ko01000 - - - Chlor_dismutase k59_40985_1 338963.Pcar_0091 1.56e-111 357.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,43SCA@69541|Desulfuromonadales 28221|Deltaproteobacteria L TRCF mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_41001_1 436308.Nmar_0433 6.83e-72 223.0 COG2123@1|root,arCOG01574@2157|Archaea,41SFZ@651137|Thaumarchaeota 651137|Thaumarchaeota J Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site rrp42 - - ko:K12589 ko03018,map03018 M00390,M00391 - - ko00000,ko00001,ko00002,ko03019 - - - RNase_PH,RNase_PH_C k59_41001_2 436308.Nmar_0432 3.6e-30 112.0 COG0689@1|root,arCOG01575@2157|Archaea,41S81@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails rrp41 - - ko:K11600 ko03018,map03018 M00390,M00391 - - ko00000,ko00001,ko00002,ko03019 - - - RNase_PH,RNase_PH_C k59_41030_1 323848.Nmul_A1041 1.56e-82 255.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,3723Q@32003|Nitrosomonadales 28216|Betaproteobacteria E PFAM aminotransferase class-III argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_41131_1 28444.JODQ01000002_gene4072 6.95e-19 89.0 COG0810@1|root,COG5002@1|root,COG0810@2|Bacteria,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4EHI2@85012|Streptosporangiales 201174|Actinobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_41131_2 272556.CF65_00997 2.28e-20 89.7 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1RMW7@1236|Gammaproteobacteria,1Y7BH@135625|Pasteurellales 135625|Pasteurellales K Response regulators consisting of a CheY-like receiver domain and a cpxR - - ko:K07662 ko01503,ko02020,map01503,map02020 M00447,M00727,M00728 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_41193_1 472759.Nhal_3928 4.05e-100 300.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1WXFU@135613|Chromatiales 135613|Chromatiales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_41310_1 1121926.AXWO01000003_gene785 3.82e-16 84.3 COG1966@1|root,COG1966@2|Bacteria,2GIYX@201174|Actinobacteria,4EZD0@85014|Glycomycetales 201174|Actinobacteria T 5TM C-terminal transporter carbon starvation CstA cstA - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM k59_41417_2 436308.Nmar_1783 1.9e-20 88.6 COG2112@1|root,arCOG01182@2157|Archaea,41SJV@651137|Thaumarchaeota 651137|Thaumarchaeota T Ser thr protein kinase - - - ko:K07176 - - - - ko00000 - - - RIO1 k59_41498_1 396588.Tgr7_0631 6.42e-06 47.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1WXK9@135613|Chromatiales 135613|Chromatiales C Belongs to the heme-copper respiratory oxidase family - - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_41498_2 322710.Avin_33240 8.61e-48 160.0 28H8Z@1|root,2Z7KS@2|Bacteria,1MW9T@1224|Proteobacteria,1RQV1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane yohC GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944 - - - - - - - - - - DUF1282 k59_41528_1 1255043.TVNIR_1880 5.08e-28 117.0 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,1S28B@1236|Gammaproteobacteria,1WZ7G@135613|Chromatiales 135613|Chromatiales L Nucleotidyltransferase DNA polymerase involved in DNA repair - - - ko:K14161 - - - - ko00000,ko03400 - - - IMS k59_41558_1 1144343.PMI41_01697 2.92e-05 50.8 COG0666@1|root,COG0790@1|root,COG0666@2|Bacteria,COG0790@2|Bacteria,1N6ZB@1224|Proteobacteria,2VFUB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Sel1-like repeats. - - - - - - - - - - - - Sel1 k59_41615_1 1298867.AUES01000085_gene3659 5.05e-09 57.4 COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_41615_2 296591.Bpro_1408 1.26e-26 102.0 COG5588@1|root,COG5588@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1326) - - - - - - - - - - - - DUF1326 k59_41637_2 1123057.P872_10545 6.01e-25 99.8 COG0251@1|root,COG0251@2|Bacteria,4NQ8M@976|Bacteroidetes,47QE4@768503|Cytophagia 976|Bacteroidetes J TIGRFAM endoribonuclease L-PSP yjgF - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_41776_1 330214.NIDE1205 6.07e-85 264.0 COG0439@1|root,COG0439@2|Bacteria,3J0YP@40117|Nitrospirae 40117|Nitrospirae I Biotin carboxylase C-terminal domain - - 6.4.1.1 ko:K01959 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_41907_1 502025.Hoch_4684 6.03e-129 407.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,42Q75@68525|delta/epsilon subdivisions,2WMDY@28221|Deltaproteobacteria,2YU11@29|Myxococcales 28221|Deltaproteobacteria L DEAD DEAH box - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_41917_1 1366050.N234_28990 2.71e-49 164.0 COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2VJS3@28216|Betaproteobacteria,1KGJZ@119060|Burkholderiaceae 28216|Betaproteobacteria H Aldolase/RraA - - 4.1.3.17 ko:K10218 ko00362,ko00660,ko01120,map00362,map00660,map01120 - R00008,R00350 RC00067,RC00502,RC01205 ko00000,ko00001,ko01000 - - - RraA-like k59_41965_1 579405.Dd703_0047 0.000492 41.6 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,1RPPD@1236|Gammaproteobacteria,2JER6@204037|Dickeya 1236|Gammaproteobacteria E Peptidase family M28 amaB_2 - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_41965_2 1121861.KB899910_gene861 2.55e-55 192.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,2JQJ8@204441|Rhodospirillales 204441|Rhodospirillales S transport system, fused permease components - - - - - - - - - - - - DctM k59_42028_1 713586.KB900536_gene69 3.09e-115 334.0 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,1RNMK@1236|Gammaproteobacteria,1WW8F@135613|Chromatiales 135613|Chromatiales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_42028_2 491952.Mar181_1891 1.7e-101 305.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1XH6T@135619|Oceanospirillales 135619|Oceanospirillales CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_42062_1 1123371.ATXH01000004_gene1784 4.82e-06 56.2 COG0501@1|root,COG0790@1|root,COG0501@2|Bacteria,COG0790@2|Bacteria,2GGYJ@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria O Peptidase family M48 - - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48 k59_42165_1 330214.NIDE0597 1.54e-30 110.0 COG0346@1|root,COG0346@2|Bacteria,3J15P@40117|Nitrospirae 40117|Nitrospirae E Glyoxalase-like domain - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_42165_2 330214.NIDE0596 1.82e-67 211.0 COG0253@1|root,COG0253@2|Bacteria,3J0JV@40117|Nitrospirae 40117|Nitrospirae E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_42212_1 1123487.KB892846_gene645 7.62e-22 98.2 COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,2VKGK@28216|Betaproteobacteria,2M01R@206389|Rhodocyclales 206389|Rhodocyclales M Phospholipase A1 - - 3.1.1.32,3.1.1.4 ko:K01058 ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110 - R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko01000 - - - PLA1 k59_42295_1 426117.M446_2854 2.05e-07 48.9 COG3360@1|root,COG3360@2|Bacteria,1N6YT@1224|Proteobacteria,2UKPX@28211|Alphaproteobacteria,1JWH1@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Dodecin - - - ko:K09165 - - - - ko00000 - - - Dodecin k59_42295_2 1227500.C494_00527 9.48e-05 47.0 COG1371@1|root,arCOG04055@2157|Archaea,2XXRX@28890|Euryarchaeota,23W79@183963|Halobacteria 183963|Halobacteria S PFAM Archease protein family (DUF101 UPF0211) - - - - - - - - - - - - Archease k59_42366_1 1198452.Jab_1c20270 4.22e-20 87.4 COG0835@1|root,COG0835@2|Bacteria,1N0R3@1224|Proteobacteria,2VUQH@28216|Betaproteobacteria,477XC@75682|Oxalobacteraceae 28216|Betaproteobacteria NT Two component signalling adaptor domain wspB - - ko:K13488 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001 - - - CheW k59_42367_1 1116472.MGMO_37c00150 3.69e-123 362.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1XEUJ@135618|Methylococcales 135618|Methylococcales C Isocitrate dehydrogenase - - - - - - - - - - - - Iso_dh k59_42426_1 316067.Geob_0004 1.28e-107 335.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,43SYW@69541|Desulfuromonadales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_42429_1 1144275.COCOR_07526 1.47e-35 135.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WKYA@28221|Deltaproteobacteria,2YU1C@29|Myxococcales 28221|Deltaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455,ko:K11745,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.1,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N k59_679516_1 522306.CAP2UW1_2729 2.81e-36 143.0 COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,2VKA1@28216|Betaproteobacteria 28216|Betaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_104763_1 95619.PM1_0202815 3.33e-72 233.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641 DFP,Flavoprotein k59_522680_1 335543.Sfum_0058 1.72e-126 375.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2MQ57@213462|Syntrophobacterales 28221|Deltaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_519_2 530564.Psta_0960 2.17e-43 159.0 COG1389@1|root,COG1389@2|Bacteria,2J2A8@203682|Planctomycetes 203682|Planctomycetes L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6B - 5.99.1.3 ko:K03167 - - - - ko00000,ko01000,ko03032 - - - HATPase_c,Topo-VIb_trans k59_1097277_1 604354.TSIB_1328 4.15e-41 149.0 COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,243GR@183968|Thermococci 183968|Thermococci E DegT/DnrJ/EryC1/StrS aminotransferase family - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1201850_1 393595.ABO_2059 1.16e-62 203.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1XIHC@135619|Oceanospirillales 135619|Oceanospirillales O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_313753_1 314278.NB231_08127 8.21e-95 308.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_366098_1 1470591.BW41_03171 9.31e-19 89.7 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2TQXJ@28211|Alphaproteobacteria,2K0AZ@204457|Sphingomonadales 204457|Sphingomonadales M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_837120_2 979556.MTES_1459 5.87e-44 155.0 COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4FKPR@85023|Microbacteriaceae 201174|Actinobacteria T Transcriptional regulatory protein, C terminal trcR - - ko:K02483,ko:K07672 ko02020,map02020 M00463 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_837120_3 1114959.SZMC14600_20614 1.94e-08 55.8 COG1938@1|root,COG1938@2|Bacteria,2GK10@201174|Actinobacteria,4EFA9@85010|Pseudonocardiales 201174|Actinobacteria S ATP-grasp superfamily - - - - - - - - - - - - PAC2 k59_1463948_1 1229909.NSED_08335 1.46e-90 280.0 COG2304@1|root,arCOG02900@2157|Archaea,41SDY@651137|Thaumarchaeota 651137|Thaumarchaeota S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_367068_1 977880.RALTA_A1081 7.67e-50 176.0 COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,2VMGB@28216|Betaproteobacteria 28216|Betaproteobacteria S Von Willebrand factor type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - DUF3520,VWA,vWF_A k59_1359527_1 1469245.JFBG01000057_gene2370 5.51e-76 237.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,1WWU0@135613|Chromatiales 135613|Chromatiales F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_1098322_1 1229909.NSED_02935 1.61e-41 145.0 COG0517@1|root,arCOG00600@2157|Archaea,41TAT@651137|Thaumarchaeota 651137|Thaumarchaeota S CBS domain - - - - - - - - - - - - CBS k59_680639_1 436308.Nmar_0319 2.44e-75 230.0 COG2178@1|root,arCOG04318@2157|Archaea,41SKR@651137|Thaumarchaeota 651137|Thaumarchaeota J Translin family - - - ko:K07477 - - - - ko00000 - - - Translin k59_1150346_1 765913.ThidrDRAFT_2728 1.2e-49 168.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,1RMFK@1236|Gammaproteobacteria,1WW26@135613|Chromatiales 135613|Chromatiales NT Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_575811_1 1123400.KB904759_gene2077 3.6e-37 132.0 COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,1S3NG@1236|Gammaproteobacteria,460PS@72273|Thiotrichales 72273|Thiotrichales S PFAM Copper chaperone SCO1 SenC - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_628463_2 160488.PP_0359 1.16e-38 139.0 COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,1RNHI@1236|Gammaproteobacteria,1YWPK@136845|Pseudomonas putida group 1236|Gammaproteobacteria F A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response srkA GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564 - - - - - - - - - - APH k59_1359531_2 323261.Noc_0983 4.07e-13 69.7 COG0462@1|root,COG0462@2|Bacteria,1QHJ7@1224|Proteobacteria,1RZJH@1236|Gammaproteobacteria,1WZXT@135613|Chromatiales 135613|Chromatiales F Ribose-phosphate pyrophosphokinase - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_1150347_1 314278.NB231_11914 2.31e-27 110.0 COG3137@1|root,COG3137@2|Bacteria,1RCKQ@1224|Proteobacteria,1S0GK@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Protein of unknown function, DUF481 - - - - - - - - - - - - DUF481 k59_1150347_2 1122247.C731_4072 1.99e-28 113.0 COG1575@1|root,COG1575@2|Bacteria,2IPQ8@201174|Actinobacteria,23E29@1762|Mycobacteriaceae 201174|Actinobacteria H Belongs to the MenA family. Type 1 subfamily - - - - - - - - - - - - UbiA k59_210237_1 247490.KSU1_B0328 1.55e-127 390.0 COG4590@1|root,COG4590@2|Bacteria,2J4XR@203682|Planctomycetes 203682|Planctomycetes U Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 k59_1620660_1 644968.DFW101_0883 1.31e-29 122.0 COG4262@1|root,COG4262@2|Bacteria,1QX9D@1224|Proteobacteria,42Q62@68525|delta/epsilon subdivisions,2WMHX@28221|Deltaproteobacteria,2M99V@213115|Desulfovibrionales 28221|Deltaproteobacteria E Spermine/spermidine synthase domain - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_1359534_1 101028.EKJ75212 2.15e-12 67.0 COG1804@1|root,KOG3957@2759|Eukaryota,38CWZ@33154|Opisthokonta,3NU4P@4751|Fungi,3QPIY@4890|Ascomycota,2175J@147550|Sordariomycetes,3TGA4@5125|Hypocreales,1FMB8@110618|Nectriaceae 4751|Fungi I to CAIB BAIF family enzyme - - 2.8.3.13 ko:K18703 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_53863_1 1210884.HG799474_gene15130 6.1e-30 113.0 COG2102@1|root,COG2102@2|Bacteria,2IXRQ@203682|Planctomycetes 203682|Planctomycetes S Diphthamide synthase - - - - - - - - - - - - Diphthami_syn_2 k59_1150364_1 316067.Geob_0690 8.85e-49 161.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,42NIV@68525|delta/epsilon subdivisions,2WNA4@28221|Deltaproteobacteria,43SWF@69541|Desulfuromonadales 28221|Deltaproteobacteria E imidazoleglycerol-phosphate dehydratase activity hisB GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD k59_1150364_2 1121334.KB911066_gene675 6.11e-68 214.0 COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,3WGIA@541000|Ruminococcaceae 186801|Clostridia E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_1620677_1 1458462.JNLK01000001_gene1698 6.47e-14 75.5 COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,249K8@186801|Clostridia,27I6M@186928|unclassified Lachnospiraceae 186801|Clostridia S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA - 2.7.7.85 ko:K18672 - - - - ko00000,ko01000 - - - DisA_N k59_1620677_2 383372.Rcas_3708 5.28e-14 68.9 COG0221@1|root,COG0221@2|Bacteria,2G6T4@200795|Chloroflexi,375J0@32061|Chloroflexia 32061|Chloroflexia C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_262551_1 713586.KB900536_gene2310 2.61e-93 283.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,1RMR1@1236|Gammaproteobacteria,1WWJ4@135613|Chromatiales 135613|Chromatiales S Radical SAM superfamily pqqE - - ko:K06139 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_53893_1 1238182.C882_1168 1.74e-93 288.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TVAD@28211|Alphaproteobacteria,2JW34@204441|Rhodospirillales 204441|Rhodospirillales Q Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase k59_53893_2 1337093.MBE-LCI_3587 1.61e-52 173.0 COG0204@1|root,COG0204@2|Bacteria,1R787@1224|Proteobacteria,2U4Y1@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase k59_941435_1 1038859.AXAU01000002_gene391 7.64e-80 262.0 COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase resE - - - - - - - - - - - HATPase_c,HisKA,PAS_7,Response_reg,SSF k59_419241_1 637389.Acaty_m0165 4.18e-63 208.0 COG3677@1|root,COG3677@2|Bacteria,1R3ZS@1224|Proteobacteria,1SZQS@1236|Gammaproteobacteria,2NDTK@225057|Acidithiobacillales 1236|Gammaproteobacteria L Transposase zinc-ribbon domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_1620700_1 1458357.BG58_11195 2.07e-60 203.0 COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VK75@28216|Betaproteobacteria,1K1T0@119060|Burkholderiaceae 28216|Betaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase paaH - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k59_210285_1 5465.ENH86208 1.23e-61 210.0 COG2828@1|root,2QSUX@2759|Eukaryota,39T7M@33154|Opisthokonta,3NZ7X@4751|Fungi,3QNRU@4890|Ascomycota,21RK2@147550|Sordariomycetes,1F7EM@1028384|Glomerellales 4751|Fungi S PrpF protein - - - - - - - - - - - - PrpF k59_157636_1 1110502.TMO_2474 6.49e-15 73.6 COG1863@1|root,COG1863@2|Bacteria,1MZYJ@1224|Proteobacteria,2UBYN@28211|Alphaproteobacteria,2JTMZ@204441|Rhodospirillales 204441|Rhodospirillales P Na+/H+ ion antiporter subunit - - - ko:K05569 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MNHE k59_1203034_2 1127673.GLIP_2482 1.17e-14 77.8 COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria,465UX@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - Big_2,CBM26,CBM_2,CBM_5_12_2,Cytochrome_CBB3,GSDH,He_PIG,PA14,PSCyt3,PSD2,PSD3,PSD4,PSD5 k59_1203034_3 1163617.SCD_n02145 1.25e-07 52.0 COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,2VHDT@28216|Betaproteobacteria 28216|Betaproteobacteria E phosphoserine phosphatase thrH - 2.7.1.39,3.1.3.3 ko:K02203 ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230 M00018 R00582,R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD,Hydrolase k59_53919_1 153948.NAL212_2818 1.4e-68 216.0 arCOG08699@1|root,30TCX@2|Bacteria,1RDPE@1224|Proteobacteria,2WAZQ@28216|Betaproteobacteria,371U8@32003|Nitrosomonadales 28216|Betaproteobacteria C PFAM Ammonia monooxygenase particulate methane monooxygenase, subunit C - - - ko:K10946 ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200 M00174,M00528,M00804 R00148,R09518 RC00173,RC02797 ko00000,ko00001,ko00002 - - - AmoC k59_1255194_1 1347342.BN863_12390 4.69e-06 52.4 COG2905@1|root,COG2905@2|Bacteria,4NDZ8@976|Bacteroidetes,1HWQU@117743|Flavobacteriia 976|Bacteroidetes T signal-transduction protein containing cAMP-binding and CBS - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_1152_1 1114964.L485_21845 7.25e-09 63.2 COG5361@1|root,COG5361@2|Bacteria,1NU7Q@1224|Proteobacteria,2UQGU@28211|Alphaproteobacteria,2K5F7@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF1214) - - - - - - - - - - - - DUF1214 k59_1152_2 1283299.AUKG01000002_gene5340 2.12e-21 86.3 COG0023@1|root,COG0023@2|Bacteria,2HR5X@201174|Actinobacteria,4CT1H@84995|Rubrobacteria 84995|Rubrobacteria J Translation initiation factor SUI1 - - - - - - - - - - - - SUI1 k59_471234_1 748247.AZKH_1496 9.05e-89 273.0 COG0462@1|root,COG0462@2|Bacteria,1R2XV@1224|Proteobacteria,2VMHX@28216|Betaproteobacteria,2KW10@206389|Rhodocyclales 2|Bacteria EF Ribose-phosphate pyrophosphokinase prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran,Pribosyltran_N k59_471234_2 1279019.ARQK01000059_gene922 3.07e-47 162.0 COG2187@1|root,COG2187@2|Bacteria,1R98V@1224|Proteobacteria,1T025@1236|Gammaproteobacteria 1236|Gammaproteobacteria S AAA domain - - - - - - - - - - - - - k59_628555_1 1382306.JNIM01000001_gene432 6.01e-11 67.8 COG0438@1|root,COG0438@2|Bacteria,2G67A@200795|Chloroflexi 200795|Chloroflexi M PFAM glycosyl transferase group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_1098395_1 1046629.Ssal_01848 0.00033 46.6 COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,4HA8S@91061|Bacilli 91061|Bacilli J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_1620731_2 89187.ISM_05465 1.82e-45 151.0 COG2128@1|root,COG2128@2|Bacteria,1N0RE@1224|Proteobacteria,2TQZK@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_419265_1 796942.HMPREF9623_00264 6.85e-24 100.0 COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia 186801|Clostridia F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas k59_419265_2 404589.Anae109_0762 5.41e-94 297.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2YUHI@29|Myxococcales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_210318_1 1122223.KB890700_gene2080 8.61e-159 463.0 COG0174@1|root,COG0174@2|Bacteria,1WM8G@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_1203064_1 1157708.KB907451_gene4573 3.07e-82 252.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2VMWW@28216|Betaproteobacteria,4ABTA@80864|Comamonadaceae 28216|Betaproteobacteria Q Fumarylacetoacetate (FAA) hydrolase family - - - - - - - - - - - - FAA_hydrolase k59_941446_3 1121904.ARBP01000049_gene4416 1.46e-58 194.0 COG3693@1|root,COG3693@2|Bacteria,4PMHJ@976|Bacteroidetes,47YJN@768503|Cytophagia 976|Bacteroidetes G Cellulase (glycosyl hydrolase family 5) - - - - - - - - - - - - Cellulase k59_993545_1 391735.Veis_4486 6.45e-17 89.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2VH0V@28216|Betaproteobacteria,4AAZJ@80864|Comamonadaceae 28216|Betaproteobacteria KL Helicase c2 dinG - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,ResIII k59_53945_1 485915.Dret_1201 3.04e-57 193.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2M7VS@213115|Desulfovibrionales 28221|Deltaproteobacteria KT PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS,PAS_9,Sigma54_activat k59_680743_2 313628.LNTAR_02794 2.89e-60 190.0 28U9I@1|root,2ZGF2@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1098407_1 1116369.KB890026_gene5523 4.58e-37 134.0 COG0329@1|root,COG0329@2|Bacteria,1MXM5@1224|Proteobacteria,2TUAG@28211|Alphaproteobacteria,43K2G@69277|Phyllobacteriaceae 28211|Alphaproteobacteria EM Belongs to the DapA family - - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_1359619_1 290397.Adeh_3633 7.34e-26 99.8 COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria,2YU2F@29|Myxococcales 28221|Deltaproteobacteria S ADP-ribosylation factor family mglA GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - ko:K06883 - - - - ko00000 - - - Arf,Ras k59_1359619_2 316067.Geob_0374 4.41e-61 193.0 COG2018@1|root,COG2018@2|Bacteria,1RDN5@1224|Proteobacteria,42S13@68525|delta/epsilon subdivisions,2WNKB@28221|Deltaproteobacteria,43T83@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM Roadblock LC7 family protein mglB - - - - - - - - - - - Robl_LC7 k59_1359619_3 1122998.AUHZ01000025_gene1304 1e-16 77.4 COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4DP0B@85009|Propionibacteriales 201174|Actinobacteria L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - HHH,RecR,Toprim_4 k59_837214_1 477184.KYC_26932 2.36e-59 200.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VHWM@28216|Betaproteobacteria,3T309@506|Alcaligenaceae 28216|Betaproteobacteria P ABC-type dipeptide oligopeptide nickel transport systems, permease components oppC - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_263557_2 1416752.AYME01000002_gene946 4.43e-13 71.6 COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria,4FKH4@85023|Microbacteriaceae 201174|Actinobacteria K Belongs to the ParB family parB GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944 - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_733676_1 1408445.JHXP01000039_gene3366 1.15e-45 164.0 COG3754@1|root,COG5010@1|root,COG3754@2|Bacteria,COG5010@2|Bacteria,1PDZM@1224|Proteobacteria,1SJD3@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Rhamnan synthesis protein F - - - ko:K07272 - - - - ko00000,ko01000,ko01003,ko01005 - - - RgpF k59_1412371_1 1502852.FG94_02572 4.47e-20 86.7 2CKE6@1|root,32ZEV@2|Bacteria,1NBRM@1224|Proteobacteria,2VX50@28216|Betaproteobacteria,477T3@75682|Oxalobacteraceae 28216|Betaproteobacteria S Family of unknown function (DUF5329) - - - - - - - - - - - - DUF5329 k59_576764_1 1121937.AUHJ01000003_gene3204 9.08e-124 363.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,1RQAM@1236|Gammaproteobacteria,465BJ@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG1473 Metal-dependent amidase aminoacylase carboxypeptidase - - - ko:K01436 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_1047063_1 391625.PPSIR1_10560 1.49e-44 157.0 COG2866@1|root,COG2866@2|Bacteria,1PFN7@1224|Proteobacteria,435GW@68525|delta/epsilon subdivisions,2WZUG@28221|Deltaproteobacteria,2Z2S7@29|Myxococcales 28221|Deltaproteobacteria E Zn_pept - - - - - - - - - - - - Peptidase_M14 k59_106469_2 472759.Nhal_3093 1.95e-55 179.0 COG1525@1|root,COG1525@2|Bacteria,1PRMJ@1224|Proteobacteria,1SAUD@1236|Gammaproteobacteria,1WYZ1@135613|Chromatiales 135613|Chromatiales L nuclease - - - - - - - - - - - - - k59_942297_1 1449048.JQKU01000005_gene4728 1.19e-15 82.8 COG2159@1|root,COG2159@2|Bacteria,2HEB4@201174|Actinobacteria,236KV@1762|Mycobacteriaceae 201174|Actinobacteria S amidohydrolase - - 4.1.1.46 ko:K14333 ko00362,ko00627,ko01120,map00362,map00627,map01120 - R00821 RC00390 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_1204271_1 368407.Memar_2362 1.48e-40 145.0 COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia 224756|Methanomicrobia I PFAM Thiolase - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAF692.Mbar_A0550 Thiolase_C,Thiolase_N k59_1204271_2 269797.Mbar_A0551 1.21e-08 56.6 COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,2N99Q@224756|Methanomicrobia 224756|Methanomicrobia I 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal - - 2.3.3.10 ko:K01641 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130 M00088,M00095 R01978 RC00004,RC00503 ko00000,ko00001,ko00002,ko01000 - - - ACP_syn_III_C,HMG_CoA_synt_N k59_733685_1 883078.HMPREF9695_02165 7.23e-07 49.7 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2TTTF@28211|Alphaproteobacteria,3JSGR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_1634029_2 1521187.JPIM01000035_gene3406 1.24e-34 122.0 COG0041@1|root,COG0041@2|Bacteria,2G6JS@200795|Chloroflexi,375UD@32061|Chloroflexia 32061|Chloroflexia F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_431889_1 5786.XP_003286863.1 2.61e-35 133.0 COG1612@1|root,KOG2725@2759|Eukaryota,3XE86@554915|Amoebozoa 554915|Amoebozoa U Cytochrome c oxidase assembly protein - - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_431889_2 765911.Thivi_0796 2.62e-24 101.0 COG4262@1|root,COG4262@2|Bacteria,1RFZS@1224|Proteobacteria,1S1NP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - - k59_431899_1 443144.GM21_3854 1.32e-28 119.0 COG1199@1|root,COG2003@1|root,COG1199@2|Bacteria,COG2003@2|Bacteria,1MVCU@1224|Proteobacteria,42N57@68525|delta/epsilon subdivisions,2WJ82@28221|Deltaproteobacteria,43U02@69541|Desulfuromonadales 28221|Deltaproteobacteria KL HELICc2 dinG - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,RadC,ResIII k59_1524350_1 1232410.KI421415_gene3029 3.2e-64 208.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42NDT@68525|delta/epsilon subdivisions,2WIWZ@28221|Deltaproteobacteria,43U9Z@69541|Desulfuromonadales 28221|Deltaproteobacteria E PFAM aspartate glutamate uridylate kinase lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_1524350_2 1123508.JH636439_gene759 2.1e-12 66.6 COG0119@1|root,COG0119@2|Bacteria,2IXBC@203682|Planctomycetes 203682|Planctomycetes E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1111363_1 1392838.AWNM01000097_gene196 1.72e-43 161.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,3T1BB@506|Alcaligenaceae 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA2 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_645234_1 1120983.KB894571_gene2250 5.23e-131 380.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,1JPZ9@119043|Rhodobiaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_953991_1 1126627.BAWE01000005_gene6285 3.15e-79 248.0 COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2TQQB@28211|Alphaproteobacteria,3JSMU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Elongator protein 3, MiaB family, Radical SAM MA20_42330 - - - - - - - - - - - Radical_SAM k59_223234_2 1121422.AUMW01000005_gene601 1.1e-30 129.0 COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia 186801|Clostridia IQ Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1581535_1 1385517.N800_00780 1.36e-154 456.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1X4EX@135614|Xanthomonadales 135614|Xanthomonadales J elongation factor G - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_1581535_2 243233.MCA0061 1.31e-56 192.0 COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1XERT@135618|Methylococcales 135618|Methylococcales U SMART ATPase, AAA type, core - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_646197_2 887929.HMP0721_2421 6.96e-10 61.6 COG1246@1|root,COG1246@2|Bacteria,1UIMS@1239|Firmicutes,24SDH@186801|Clostridia 186801|Clostridia E Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_1218880_2 1173028.ANKO01000124_gene2876 1.59e-20 90.1 COG0500@1|root,COG2226@2|Bacteria,1GAKY@1117|Cyanobacteria,1HEY5@1150|Oscillatoriales 1117|Cyanobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_903183_1 1469245.JFBG01000010_gene622 1.36e-76 239.0 COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,1RRSU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the LDH2 MDH2 oxidoreductase family comC - 1.1.1.338,1.5.1.21 ko:K13609,ko:K16844 ko00270,ko00310,ko00960,ko01100,ko01120,map00270,map00310,map00960,map01100,map01120 - R02203,R07137 RC00031,RC00135 ko00000,ko00001,ko01000 - - - Ldh_2 k59_1007087_2 404589.Anae109_2702 2.32e-112 334.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,42N5A@68525|delta/epsilon subdivisions,2WKKI@28221|Deltaproteobacteria,2YUUT@29|Myxococcales 28221|Deltaproteobacteria O AAA domain (Cdc48 subfamily) clpB1 - - - - - - - - - - - AAA,AAA_5 k59_119716_1 228410.NE2317 6.86e-53 187.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,37235@32003|Nitrosomonadales 28216|Betaproteobacteria M PFAM glycosyl transferase, family 51 mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_695924_1 1265505.ATUG01000001_gene3627 2.61e-37 142.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MI52@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM ferredoxin - - - - - - - - - - - - DUF4445,Fer2 k59_381925_1 986075.CathTA2_0037 2.04e-31 118.0 2AHMV@1|root,317ZT@2|Bacteria,1VPFH@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - k59_1060034_1 268746.Q58MG0_BPPRM 4.47e-123 367.0 4QDUC@10239|Viruses,4QV7K@35237|dsDNA viruses no RNA stage,4QR22@28883|Caudovirales,4QJ6D@10662|Myoviridae 10662|Myoviridae S transferase activity - - - - - - - - - - - - - k59_1272995_1 452662.SJA_C1-04790 1.21e-75 235.0 COG0462@1|root,COG0462@2|Bacteria,1MUV7@1224|Proteobacteria,2U3AB@28211|Alphaproteobacteria,2K1GU@204457|Sphingomonadales 204457|Sphingomonadales F Belongs to the ribose-phosphate pyrophosphokinase family - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran,Pribosyltran_N k59_1272995_2 883080.HMPREF9697_00894 4.61e-29 116.0 COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,2TS24@28211|Alphaproteobacteria,3JQN1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria F Thymidine phosphorylase - - 2.4.2.4 ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C k59_903199_1 243090.RB3622 9.21e-68 219.0 COG3004@1|root,COG3004@2|Bacteria,2IY36@203682|Planctomycetes 203682|Planctomycetes P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_537041_2 1144275.COCOR_06286 3.63e-109 328.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2YU38@29|Myxococcales 28221|Deltaproteobacteria NU Type II secretion system (T2SS), protein F pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_850761_1 1125863.JAFN01000001_gene1869 1.2e-46 167.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Phenylalanyl-tRNA synthetase, beta subunit pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_850761_2 1229831.M832_05390 9.96e-10 58.2 COG0016@1|root,COG0016@2|Bacteria,2JFFZ@204428|Chlamydiae 204428|Chlamydiae J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_329052_1 1313421.JHBV01000002_gene566 5.74e-48 170.0 COG2317@1|root,COG2317@2|Bacteria,4NK5Q@976|Bacteroidetes,1IVUK@117747|Sphingobacteriia 976|Bacteroidetes E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues - - 3.4.17.19 ko:K01299 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M32 k59_1112184_1 469383.Cwoe_3187 2.83e-48 174.0 COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4CPMB@84995|Rubrobacteria 84995|Rubrobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1319344_1 525904.Tter_0579 3.5e-36 138.0 COG0801@1|root,COG1469@1|root,COG0801@2|Bacteria,COG1469@2|Bacteria,2NPPF@2323|unclassified Bacteria 2|Bacteria H 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase folK - 2.7.6.3,3.5.4.16,3.5.4.39,4.1.2.25 ko:K00950,ko:K09007,ko:K13940,ko:K17488 ko00790,ko01100,map00790,map01100 M00126,M00841 R00428,R03503,R03504,R04639,R05046,R05048,R10348 RC00002,RC00017,RC00263,RC00294,RC00323,RC00721,RC00943,RC00945,RC01188,RC02504,RC03131 ko00000,ko00001,ko00002,ko01000 - - - FolB,HPPK k59_695949_1 880072.Desac_2842 1.17e-42 150.0 COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,42MUE@68525|delta/epsilon subdivisions,2WJFZ@28221|Deltaproteobacteria,2MR9K@213462|Syntrophobacterales 28221|Deltaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - rve k59_695949_2 880072.Desac_2841 1.78e-38 135.0 COG2963@1|root,COG2963@2|Bacteria,1NDY6@1224|Proteobacteria,42VHR@68525|delta/epsilon subdivisions,2WSES@28221|Deltaproteobacteria,2MS3D@213462|Syntrophobacterales 28221|Deltaproteobacteria L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_487451_2 414684.RC1_3257 8.55e-24 99.0 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2TR7D@28211|Alphaproteobacteria,2JRC6@204441|Rhodospirillales 204441|Rhodospirillales C CoA-transferase family III - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_646252_1 1167006.UWK_03278 1.01e-15 75.5 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,42QPE@68525|delta/epsilon subdivisions,2WN39@28221|Deltaproteobacteria,2MKUD@213118|Desulfobacterales 28221|Deltaproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_646252_2 715451.ambt_03500 9.63e-52 177.0 28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,1RQUY@1236|Gammaproteobacteria,464CA@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_903222_1 243233.MCA2616 6.11e-54 176.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,1S510@1236|Gammaproteobacteria,1XEBJ@135618|Methylococcales 135618|Methylococcales S Rhomboid family - - - - - - - - - - - - Rhomboid k59_1524904_1 436308.Nmar_1720 3.72e-101 300.0 COG0413@1|root,arCOG00584@2157|Archaea,41SZX@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_1007125_1 1192034.CAP_2988 1.26e-95 298.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42PGI@68525|delta/epsilon subdivisions,2WMBT@28221|Deltaproteobacteria,2YYDR@29|Myxococcales 28221|Deltaproteobacteria S Iron-sulfur cluster-binding domain - - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM k59_1112194_2 1280952.HJA_01600 7.07e-85 270.0 COG2124@1|root,COG2124@2|Bacteria,1MV8Q@1224|Proteobacteria,2TU15@28211|Alphaproteobacteria,43XG3@69657|Hyphomonadaceae 28211|Alphaproteobacteria C Belongs to the cytochrome P450 family - - - - - - - - - - - - p450 k59_71592_1 266265.Bxe_C1034 4.7e-22 96.7 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2VJVA@28216|Betaproteobacteria,1K3KP@119060|Burkholderiaceae 28216|Betaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_1112197_1 469383.Cwoe_2781 7.5e-09 62.4 COG0747@1|root,COG0747@2|Bacteria,2HEVF@201174|Actinobacteria,4CSTE@84995|Rubrobacteria 84995|Rubrobacteria E PFAM extracellular solute-binding protein, family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_954800_1 1459636.NTE_03071 4.38e-33 125.0 COG0861@1|root,arCOG09430@2157|Archaea 2157|Archaea P PFAM Integral membrane protein TerC - - - ko:K05794 - - - - ko00000 - - - TerC k59_1581600_1 222534.KB893715_gene1699 1.41e-30 117.0 COG0346@1|root,COG0346@2|Bacteria,2GN2E@201174|Actinobacteria,4ETGE@85013|Frankiales 201174|Actinobacteria E Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Glyoxalase k59_1581600_2 1429916.X566_05025 5.69e-43 148.0 COG1028@1|root,COG1028@2|Bacteria,1MWJI@1224|Proteobacteria,2TRNJ@28211|Alphaproteobacteria,3JS4Z@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase MA20_19195 - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_169686_1 330214.NIDE0599 1.72e-70 219.0 COG0726@1|root,COG0726@2|Bacteria 2|Bacteria G polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_169686_2 330214.NIDE0598 8.22e-67 207.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - 3.5.1.104 ko:K22278 - - - - ko00000,ko01000 - - - Acetyltransf_1,Acetyltransf_10 k59_589511_1 565045.NOR51B_2835 2.17e-40 150.0 COG1231@1|root,COG1231@2|Bacteria,1QXX6@1224|Proteobacteria,1T3IZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - 1.5.99.6 ko:K00316 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R01914,R01915 RC00053,RC00225 ko00000,ko00001,ko01000 - - - NAD_binding_8 k59_1273056_1 402881.Plav_1446 8.11e-69 224.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2TSMD@28211|Alphaproteobacteria,1JNAI@119043|Rhodobiaceae 28211|Alphaproteobacteria C Aldehyde dehydrogenase family mmsA GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008150,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1273056_2 1469245.JFBG01000014_gene2037 2.41e-11 62.8 COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,1RQ0A@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC-type nitrate sulfonate bicarbonate transport system permease component - - - ko:K15552 ko00920,ko02010,map00920,map02010 M00435 - - ko00000,ko00001,ko00002,ko02000 3.A.1.17.1,3.A.1.17.4 - - BPD_transp_1 k59_487479_1 43354.JOIJ01000011_gene2721 4.12e-19 91.3 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4E1PC@85010|Pseudonocardiales 201174|Actinobacteria J Belongs to the amidase family - - 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1635143_1 1229909.NSED_06945 2.13e-43 150.0 COG0379@1|root,arCOG04459@2157|Archaea,41S6Y@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_1635143_2 1459636.NTE_02247 3.78e-21 91.3 COG0535@1|root,arCOG00938@2157|Archaea,41SXS@651137|Thaumarchaeota 651137|Thaumarchaeota S 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Radical_SAM k59_954805_1 870187.Thini_1528 1.93e-105 316.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed yqeF GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034308,GO:0034309,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046165,GO:0046395,GO:0055114,GO:0071270,GO:0071271,GO:0071704,GO:0072329,GO:1901575,GO:1901576,GO:1901615,GO:1901617 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - iSSON_1240.SSON_3004 Thiolase_C,Thiolase_N k59_1319360_1 436308.Nmar_0052 5.55e-95 281.0 COG0177@1|root,arCOG00459@2157|Archaea,41SFM@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD k59_487487_1 1122603.ATVI01000005_gene3729 7.08e-62 202.0 COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,1RS4S@1236|Gammaproteobacteria,1X9AR@135614|Xanthomonadales 135614|Xanthomonadales S Branched-chain amino acid transport system / permease component - - - - - - - - - - - - BPD_transp_2 k59_1162834_1 1120956.JHZK01000010_gene2774 2.28e-96 302.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,1JMYT@119043|Rhodobiaceae 28211|Alphaproteobacteria P Oligopeptide/dipeptide transporter, C-terminal region gsiA3 - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_487492_1 1499685.CCFJ01000053_gene2971 7.97e-69 220.0 COG0604@1|root,COG0604@2|Bacteria,1TPGA@1239|Firmicutes,4HBKZ@91061|Bacilli,1ZDYJ@1386|Bacillus 91061|Bacilli C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_695985_1 105559.Nwat_1516 2.25e-98 301.0 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria,1WVV8@135613|Chromatiales 135613|Chromatiales C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_695985_2 1304874.JAFY01000005_gene1616 1.62e-14 74.7 COG0725@1|root,COG0725@2|Bacteria,3TB5M@508458|Synergistetes 508458|Synergistetes P ABC transporter, periplasmic molybdate-binding protein - - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_954824_3 1137745.H6WG78_9CAUD 3.25e-06 49.7 4QCT9@10239|Viruses,4QXZB@35237|dsDNA viruses no RNA stage,4QR2V@28883|Caudovirales,4QKDU@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_589533_1 1265502.KB905934_gene3292 1.74e-108 342.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,4AC69@80864|Comamonadaceae 28216|Betaproteobacteria EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_1007166_2 436308.Nmar_0761 1.01e-20 84.7 arCOG10545@1|root,arCOG10545@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_169718_1 1038859.AXAU01000018_gene6727 1.75e-137 397.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,3JQYC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_803403_2 765913.ThidrDRAFT_1770 1.68e-07 51.2 COG0662@1|root,COG0662@2|Bacteria,1RFTK@1224|Proteobacteria,1S5QK@1236|Gammaproteobacteria,1WYE9@135613|Chromatiales 135613|Chromatiales G PFAM Cupin - - - - - - - - - - - - Cupin_2 k59_1014309_2 1304883.KI912532_gene696 2.32e-31 112.0 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2VUFB@28216|Betaproteobacteria,2KWWQ@206389|Rhodocyclales 206389|Rhodocyclales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_336003_2 886377.Murru_0984 2.43e-16 81.3 COG2182@1|root,COG2182@2|Bacteria,4PKIT@976|Bacteroidetes,1IJAD@117743|Flavobacteriia 976|Bacteroidetes G Parallel beta-helix repeats - - - - - - - - - - - - - k59_1282717_2 1229909.NSED_01720 8.44e-89 265.0 COG0727@1|root,arCOG02579@2157|Archaea,41SH8@651137|Thaumarchaeota 651137|Thaumarchaeota S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_543777_1 523791.Kkor_2500 1.43e-41 153.0 COG1360@1|root,COG3455@1|root,COG1360@2|Bacteria,COG3455@2|Bacteria,1MU13@1224|Proteobacteria,1T1GU@1236|Gammaproteobacteria,1XR5C@135619|Oceanospirillales 135619|Oceanospirillales N Type VI secretion system protein DotU - - - ko:K11892 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - DotU,OmpA k59_702982_1 562970.Btus_2806 1.17e-34 136.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,4HB12@91061|Bacilli,2786P@186823|Alicyclobacillaceae 91061|Bacilli L DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_702983_1 1177179.A11A3_01947 6.22e-20 95.1 COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,1RS8E@1236|Gammaproteobacteria,1XIGN@135619|Oceanospirillales 135619|Oceanospirillales I COG3000 Sterol desaturase - - 1.14.19.20 ko:K00227 ko00100,ko01100,ko01110,ko01130,map00100,map01100,map01110,map01130 M00101,M00102 R07215,R07486,R07491,R07505 RC00904 ko00000,ko00001,ko00002,ko01000 - - - FA_hydroxylase k59_702983_2 1123240.ATVO01000006_gene1605 1.39e-47 165.0 COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,2TT68@28211|Alphaproteobacteria,2K2GA@204457|Sphingomonadales 204457|Sphingomonadales I sterol desaturase - - - - - - - - - - - - FA_hydroxylase k59_812797_1 1227495.C487_12803 2.1e-33 122.0 arCOG00516@1|root,arCOG00516@2157|Archaea,2XY9V@28890|Euryarchaeota,23W96@183963|Halobacteria 183963|Halobacteria S Pyridoxamine 5'-phosphate - - - - - - - - - - - - Putative_PNPOx,Pyridox_ox_2 k59_702986_1 395961.Cyan7425_4298 3.27e-79 246.0 COG1088@1|root,COG1088@2|Bacteria,1G045@1117|Cyanobacteria,3KH6X@43988|Cyanothece 1117|Cyanobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_858074_1 518766.Rmar_2766 4.94e-124 375.0 COG1529@1|root,COG1529@2|Bacteria,4NFF5@976|Bacteroidetes 976|Bacteroidetes C Aldehyde oxidase and xanthine dehydrogenase a b hammerhead - - 1.17.1.4,1.2.5.3 ko:K03520,ko:K11177 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103,R11168 RC00143,RC02800 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1436598_1 111781.Lepto7376_3538 4.87e-32 130.0 COG2931@1|root,COG2931@2|Bacteria,1G69X@1117|Cyanobacteria,1HAQZ@1150|Oscillatoriales 1117|Cyanobacteria Q COGs COG2931 RTX toxins and related Ca2 -binding protein - - - - - - - - - - - - HemolysinCabind,Lectin_C k59_1014345_1 1434929.X946_2091 1.28e-52 189.0 COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,1JZT2@119060|Burkholderiaceae 28216|Betaproteobacteria T adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - AAA_16,BTAD,Guanylate_cyc,Pkinase,SAM_1 k59_1282763_1 1218352.B597_001305 2.22e-45 151.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,1Z1CP@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_1282763_2 1163617.SCD_n00076 9.65e-07 48.1 COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2VR5Y@28216|Betaproteobacteria 28216|Betaproteobacteria S membrane - - - ko:K08973 - - - - ko00000 - - - UPF0093 k59_1490382_1 1395587.P364_0119040 6.03e-39 144.0 COG2124@1|root,COG2124@2|Bacteria,1TPWZ@1239|Firmicutes,4HAGS@91061|Bacilli,26V2H@186822|Paenibacillaceae 91061|Bacilli Q cytochrome P450 - - - - - - - - - - - - p450 k59_390140_1 867903.ThesuDRAFT_00380 1.03e-20 97.8 COG0558@1|root,COG1213@1|root,COG0558@2|Bacteria,COG1213@2|Bacteria,1V33I@1239|Firmicutes 1239|Firmicutes IM Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.7.74,2.7.8.34 ko:K07281,ko:K07291 ko00562,map00562 - R09669,R09670 RC00002,RC00078 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf,NTP_transf_3 k59_81045_1 709032.Sulku_1056 2.91e-39 137.0 COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,42PUJ@68525|delta/epsilon subdivisions,2YN9G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EH Reduction of activated sulfate into sulfite cysH - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_128251_1 221288.JH992901_gene848 2.24e-52 189.0 COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2203@1|root,COG5002@1|root,COG5278@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,COG5278@2|Bacteria,1G09B@1117|Cyanobacteria,1JH73@1189|Stigonemataceae 1117|Cyanobacteria T GAF domain - - - - - - - - - - - - CHASE3,GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg k59_128251_2 391937.NA2_19423 1.18e-07 54.3 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,43IU8@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains tacA GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - - - - - - - - - - HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat k59_1490392_1 266117.Rxyl_1929 3.42e-86 277.0 COG1067@1|root,COG1067@2|Bacteria,2H2TE@201174|Actinobacteria 201174|Actinobacteria O AAA domain - - - - - - - - - - - - AAA_32,Lon_C k59_543816_1 297246.lpp1089 1.71e-28 121.0 COG1670@1|root,COG2320@1|root,COG1670@2|Bacteria,COG2320@2|Bacteria,1RH46@1224|Proteobacteria,1SREN@1236|Gammaproteobacteria,1JCRK@118969|Legionellales 118969|Legionellales J GrpB protein - - - - - - - - - - - - Acetyltransf_3,DUF4111,GrpB k59_496930_1 317936.Nos7107_5056 5.51e-09 57.4 COG0848@1|root,COG0848@2|Bacteria,1G71E@1117|Cyanobacteria,1HNZ7@1161|Nostocales 1117|Cyanobacteria U PFAM Biopolymer transport protein ExbD TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_1436619_2 1123368.AUIS01000005_gene447 2.93e-10 61.2 COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,1RP34@1236|Gammaproteobacteria,2NBSM@225057|Acidithiobacillales 225057|Acidithiobacillales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - 2.7.13.3 ko:K07711 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_1282781_1 768671.ThimaDRAFT_0602 1.49e-120 384.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW08@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_81063_1 1304880.JAGB01000001_gene616 4.44e-76 251.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia 186801|Clostridia G hydrolase, family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_283682_1 1121013.P873_13070 1.93e-28 120.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_1643535_1 1131266.ARWQ01000010_gene35 1.51e-16 84.0 arCOG08733@1|root,arCOG08733@2157|Archaea,41SRN@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_441039_1 1479237.JMLY01000001_gene3411 3.99e-13 69.3 COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,466M1@72275|Alteromonadaceae 1236|Gammaproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_441039_2 1049564.TevJSym_ap00360 5.97e-195 552.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1J4EQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor bioA GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUTI89_1310.UTI89_C0772,iZ_1308.Z0993 Aminotran_3 k59_390155_1 396588.Tgr7_1844 6.61e-147 444.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WW6D@135613|Chromatiales 135613|Chromatiales C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_496943_1 1184267.A11Q_2349 1.03e-43 155.0 COG0535@1|root,COG0535@2|Bacteria,1NTQX@1224|Proteobacteria,437IF@68525|delta/epsilon subdivisions,2MTNN@213481|Bdellovibrionales,2X2RZ@28221|Deltaproteobacteria 213481|Bdellovibrionales S radical SAM domain protein - - - - - - - - - - - - - k59_441043_3 1325130.HFN_1907 2.64e-66 228.0 COG1232@1|root,COG1232@2|Bacteria,1MX35@1224|Proteobacteria,42QDK@68525|delta/epsilon subdivisions 1224|Proteobacteria H Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_441043_4 589865.DaAHT2_2411 2.55e-37 138.0 COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42PFW@68525|delta/epsilon subdivisions,2WJ1N@28221|Deltaproteobacteria,2MI4U@213118|Desulfobacterales 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,Radical_SAM k59_1119151_1 1265313.HRUBRA_01073 1.14e-84 260.0 COG3367@1|root,COG3367@2|Bacteria,1MVEX@1224|Proteobacteria,1RNVG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF1611_N) Rossmann-like domain - - - - - - - - - - - - DUF1611,DUF1611_N k59_230858_1 187272.Mlg_1900 5.32e-161 471.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1WVW2@135613|Chromatiales 135613|Chromatiales O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_81091_1 1123320.KB889562_gene6741 1.35e-106 316.0 COG1028@1|root,COG1028@2|Bacteria,2GK20@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_1436653_1 671143.DAMO_2380 1.2e-180 514.0 COG0520@1|root,COG0520@2|Bacteria,2NNS0@2323|unclassified Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_1436653_2 1255043.TVNIR_3083 2.34e-52 170.0 COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria 1236|Gammaproteobacteria C A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters nifU - - ko:K04488 - - - - ko00000 - - - NifU_N k59_81101_1 1313172.YM304_09490 8.5e-65 223.0 COG1201@1|root,COG1201@2|Bacteria,2I6VR@201174|Actinobacteria,4CNBF@84992|Acidimicrobiia 84992|Acidimicrobiia L DEAD-like helicases superfamily - - - ko:K03724,ko:K06877 - - - - ko00000,ko01000,ko03400 - - - DEAD,Helicase_C k59_961551_1 159749.K0RAH1 1.09e-61 202.0 COG0299@1|root,KOG3076@2759|Eukaryota,2XBM4@2836|Bacillariophyta 2836|Bacillariophyta G Formyl transferase - - - - - - - - - - - - Formyl_trans_N k59_1119172_1 1206732.BAGD01000097_gene4088 8.35e-05 45.8 COG3173@1|root,COG3173@2|Bacteria,2GSTN@201174|Actinobacteria,4FY7Q@85025|Nocardiaceae 201174|Actinobacteria S Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_1168238_1 545264.KB898744_gene2061 6.09e-130 377.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1WWRH@135613|Chromatiales 135613|Chromatiales G Fructose-bisphosphate aldolase, class II, Calvin cycle subtype - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_596663_1 349521.HCH_03860 9.15e-101 304.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1XH2G@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_1436671_1 706587.Desti_5521 2.93e-46 152.0 COG5496@1|root,COG5496@2|Bacteria,1RKFT@1224|Proteobacteria,42TER@68525|delta/epsilon subdivisions,2WPKW@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Thioesterase - - 3.1.2.29 ko:K18700 - - - - ko00000,ko01000 - - - 4HBT k59_336104_1 1188256.BASI01000001_gene782 1.68e-108 341.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,3FCG5@34008|Rhodovulum 28211|Alphaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_812918_1 396588.Tgr7_2037 3.01e-59 197.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WWEY@135613|Chromatiales 135613|Chromatiales C FAD linked oxidase - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_230890_1 626887.J057_16745 6.15e-35 134.0 COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,46408@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG0823 Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - PD40 k59_230890_2 864051.BurJ1DRAFT_1748 9.59e-11 62.0 COG3807@1|root,COG3807@2|Bacteria,1RE8W@1224|Proteobacteria,2W17I@28216|Betaproteobacteria,1KN07@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Bacterial SH3 domain - - - - - - - - - - - - SH3_4 k59_1379869_1 617140.AJZE01000014_gene1154 1.6e-42 152.0 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1XUTK@135623|Vibrionales 135623|Vibrionales M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella - - - - - - - - - - - - SBP_bac_3,SLT k59_175340_1 1282876.BAOK01000001_gene1441 1.24e-40 149.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2TUEW@28211|Alphaproteobacteria,4BQN7@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria EGP Sugar (and other) transporter tetA - - ko:K08151 - M00668 - - ko00000,ko00002,ko01504,ko02000 2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75 - - MFS_1,Sugar_tr k59_655855_1 1121381.JNIV01000159_gene213 1.18e-07 62.0 COG1132@1|root,COG1132@2|Bacteria,1WIMR@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus V ABC-type multidrug transport system ATPase and permease - - - ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_910564_1 472759.Nhal_2510 4.93e-152 437.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1WX3U@135613|Chromatiales 135613|Chromatiales C PFAM Alcohol dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_442318_1 472759.Nhal_0556 1.45e-68 225.0 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,1WX3X@135613|Chromatiales 135613|Chromatiales N PFAM ABC-type uncharacterised transport system - - - - - - - - - - - - ABC_transp_aux k59_1068276_1 640081.Dsui_0224 4.23e-71 224.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2VIBJ@28216|Betaproteobacteria,2KVQD@206389|Rhodocyclales 206389|Rhodocyclales K LysR substrate binding domain - - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_814191_1 591167.Sfla_1120 0.000313 51.2 COG4409@1|root,COG4409@2|Bacteria,2I0CJ@201174|Actinobacteria 201174|Actinobacteria G BNR Asp-box repeat - - 3.2.1.18 ko:K01186 ko00511,ko00600,ko04142,map00511,map00600,map04142 - R04018 RC00028,RC00077 ko00000,ko00001,ko01000,ko02042 - GH33 - BNR_2,DUF4091,F5_F8_type_C,NPCBM,NPCBM_assoc k59_1015405_1 1229909.NSED_06420 1.07e-84 255.0 COG3467@1|root,arCOG00520@2157|Archaea,41SJ5@651137|Thaumarchaeota 651137|Thaumarchaeota S Pyridoxamine 5'-phosphate - - - ko:K07005 - - - - ko00000 - - - Pyridox_ox_2 k59_1284148_1 314285.KT71_15254 1.79e-55 186.0 COG1757@1|root,COG1757@2|Bacteria,1MY5C@1224|Proteobacteria,1RP6I@1236|Gammaproteobacteria,1J8QU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Na+/H+ antiporter family - - - - - - - - - - - - Na_H_antiporter k59_1589969_1 420324.KI911940_gene5200 1.85e-22 92.8 COG2801@1|root,COG2801@2|Bacteria,1N4JW@1224|Proteobacteria,2UEHC@28211|Alphaproteobacteria,1JZ63@119045|Methylobacteriaceae 28211|Alphaproteobacteria L HTH-like domain - - - - - - - - - - - - HTH_21 k59_93025_1 331869.BAL199_10607 2.73e-67 224.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,4BPA1@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Oligopeptide/dipeptide transporter, C-terminal region gsiA1 - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_921470_1 1030157.AFMP01000007_gene3157 1.48e-08 59.7 COG5517@1|root,COG5517@2|Bacteria,1NN6V@1224|Proteobacteria,2VAW8@28211|Alphaproteobacteria,2K7S6@204457|Sphingomonadales 204457|Sphingomonadales Q SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_294404_1 1453500.AT05_00810 3.28e-88 266.0 COG0479@1|root,COG0479@2|Bacteria,4NFR3@976|Bacteroidetes,1HYVV@117743|Flavobacteriia 976|Bacteroidetes C Succinate dehydrogenase fumarate reductase Fe-S protein subunit frdB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_7,Fer4_8 k59_452660_2 460265.Mnod_2771 6.47e-80 254.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,1JTCM@119045|Methylobacteriaceae 28211|Alphaproteobacteria C PFAM L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_1295272_1 1469245.JFBG01000046_gene2241 1.84e-120 372.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WXAN@135613|Chromatiales 135613|Chromatiales C FAD linked oxidases, C-terminal domain - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_866961_1 1382306.JNIM01000001_gene3777 2.43e-32 131.0 COG2303@1|root,COG2303@2|Bacteria,2G7EB@200795|Chloroflexi 200795|Chloroflexi E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_1176375_1 765912.Thimo_1974 5.63e-31 120.0 COG0741@1|root,COG0790@1|root,COG0741@2|Bacteria,COG0790@2|Bacteria,1MZ4X@1224|Proteobacteria,1S8R3@1236|Gammaproteobacteria,1WZ62@135613|Chromatiales 135613|Chromatiales M Transglycosylase SLT domain - - - - - - - - - - - - DUF4124,SLT k59_1537894_1 1123368.AUIS01000004_gene120 5.32e-73 247.0 COG2202@1|root,COG3829@1|root,COG4251@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,1T2K7@1236|Gammaproteobacteria,2NDJ6@225057|Acidithiobacillales 1236|Gammaproteobacteria T PAS fold - - - - - - - - - - - - DUF4118,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Phosphonate-bd k59_1502825_1 1408422.JHYF01000001_gene3014 5.84e-53 174.0 COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,24HWS@186801|Clostridia,36E62@31979|Clostridiaceae 186801|Clostridia J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_398079_1 1238182.C882_0079 7.02e-14 73.6 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2TS1Q@28211|Alphaproteobacteria,2JPWE@204441|Rhodospirillales 204441|Rhodospirillales D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_398079_2 1278073.MYSTI_06189 1.78e-12 67.8 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,2YTZH@29|Myxococcales 28221|Deltaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_139635_1 365528.KB891240_gene6073 7.54e-66 216.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria 201174|Actinobacteria Q cytochrome p450 - - - - - - - - - - - - p450 k59_1176390_1 580327.Tthe_0741 1.43e-14 75.1 COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,42J66@68295|Thermoanaerobacterales 186801|Clostridia T PFAM sigma-54 factor interaction domain-containing protein - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_183042_1 717785.HYPMC_3762 6.35e-37 132.0 COG2854@1|root,COG2854@2|Bacteria,1N275@1224|Proteobacteria,2UCGN@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q PFAM toluene tolerance family protein - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_398085_1 472759.Nhal_1217 9.52e-115 337.0 COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,1RN2Z@1236|Gammaproteobacteria,1X03U@135613|Chromatiales 135613|Chromatiales C Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal - - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Glyoxalase,Glyoxalase_5 k59_398085_2 1380391.JIAS01000012_gene4083 1.75e-22 95.1 COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,2TRFI@28211|Alphaproteobacteria,2JPCP@204441|Rhodospirillales 204441|Rhodospirillales Q homogentisate 1,2-dioxygenase - - 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 - - - HgmA k59_1656177_1 1047013.AQSP01000080_gene367 1.31e-51 186.0 COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2NNZG@2323|unclassified Bacteria 2|Bacteria L UvrD/REP helicase N-terminal domain - - 3.6.4.12 ko:K03657,ko:K07465 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_183045_1 1229204.AMYY01000003_gene944 7.85e-06 49.3 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,4BR4G@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - ko:K06400 - - - - ko00000 - - - Recombinase,Resolvase,Zn_ribbon_recom k59_668381_1 1207063.P24_03376 5.18e-18 82.8 COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2U8WM@28211|Alphaproteobacteria,2JZFM@204441|Rhodospirillales 204441|Rhodospirillales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_668381_2 672.VV93_v1c23090 5.15e-29 106.0 COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,1S91G@1236|Gammaproteobacteria,1XYE9@135623|Vibrionales 135623|Vibrionales T Belongs to the BolA IbaG family bolA GO:0008150,GO:0008360,GO:0022603,GO:0022604,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008 - ko:K05527 - - - - ko00000,ko03000 - - - BolA k59_1656189_1 710685.MycrhN_1278 2.07e-86 268.0 COG0677@1|root,COG0677@2|Bacteria,2GK5K@201174|Actinobacteria,232R6@1762|Mycobacteriaceae 201174|Actinobacteria M PFAM UDP-glucose GDP-mannose dehydrogenase family, NAD binding domain wbpA - 1.1.1.136,1.1.1.336 ko:K02472,ko:K13015 ko00520,ko05111,map00520,map05111 - R00421,R03317 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_14904_1 1026882.MAMP_00766 6.3e-124 373.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNNJ@1236|Gammaproteobacteria,4607G@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1597584_1 1056816.JAFQ01000003_gene7201 5.12e-41 140.0 COG0714@1|root,COG0714@2|Bacteria,2GWNF@201174|Actinobacteria,4FXHU@85025|Nocardiaceae 201174|Actinobacteria S AAA domain (dynein-related subfamily) - - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5,CbbQ_C k59_1597584_2 1056816.JAFQ01000003_gene7202 1.05e-71 236.0 COG4548@1|root,COG4548@2|Bacteria,2GIYK@201174|Actinobacteria,4FYZ0@85025|Nocardiaceae 201174|Actinobacteria P von Willebrand factor (vWF) type A domain - - - - - - - - - - - - VWA,VWA_2 k59_553025_1 1301098.PKB_4103 5.06e-57 194.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria 1236|Gammaproteobacteria E asparagine synthase, glutamine-hydrolyzing asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_346493_1 1217718.ALOU01000112_gene4316 5.22e-45 163.0 COG1075@1|root,COG1075@2|Bacteria,1NSK3@1224|Proteobacteria,2WG1G@28216|Betaproteobacteria,1KI8H@119060|Burkholderiaceae 28216|Betaproteobacteria S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - - k59_825500_1 671143.DAMO_2933 4.8e-45 147.0 COG2929@1|root,COG2929@2|Bacteria 2|Bacteria S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - ko:K09803 - - - - ko00000 - - - BrnT_toxin k59_825500_2 1121405.dsmv_3345 4.85e-30 108.0 COG5304@1|root,COG5304@2|Bacteria,1N9U3@1224|Proteobacteria,4320A@68525|delta/epsilon subdivisions,2WWJS@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1078069_1 710687.KI912270_gene136 9.11e-14 73.6 COG5421@1|root,COG5421@2|Bacteria,2GK2A@201174|Actinobacteria,23705@1762|Mycobacteriaceae 201174|Actinobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_1078069_2 502025.Hoch_4029 2.08e-08 55.1 COG0642@1|root,COG0784@1|root,COG3850@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3850@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2YXI4@29|Myxococcales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_14907_1 857087.Metme_0886 4.53e-72 228.0 COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,1RM7T@1236|Gammaproteobacteria,1XE2G@135618|Methylococcales 135618|Methylococcales E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metAS GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0008899,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - HTS k59_1078070_2 1187851.A33M_0718 7.8e-12 69.3 COG1995@1|root,COG3395@1|root,COG1995@2|Bacteria,COG3395@2|Bacteria,1MX5W@1224|Proteobacteria,2TSKF@28211|Alphaproteobacteria,3FCZ3@34008|Rhodovulum 28211|Alphaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262,1.1.1.408,1.1.1.409 ko:K00097,ko:K22024 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_183062_1 1123518.ARWI01000001_gene1966 2.32e-41 145.0 COG2863@1|root,COG2863@2|Bacteria,1R8K9@1224|Proteobacteria,1S1Q4@1236|Gammaproteobacteria,462T6@72273|Thiotrichales 72273|Thiotrichales C Cytochrome c class I - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_1502872_1 268746.Q58M97_BPPRM 2.51e-29 112.0 4QCFA@10239|Viruses,4QUPF@35237|dsDNA viruses no RNA stage,4QQD7@28883|Caudovirales,4QIYX@10662|Myoviridae 10662|Myoviridae S coenzyme binding - - - - - - - - - - - - - k59_1502872_2 444860.E3SJA0_9CAUD 1.81e-48 165.0 4QBQH@10239|Viruses,4QZ5U@35237|dsDNA viruses no RNA stage,4QU2Y@28883|Caudovirales,4QJJN@10662|Myoviridae 10662|Myoviridae S galactoside 2-alpha-L-fucosyltransferase activity - - - - - - - - - - - - - k59_346513_2 497321.C664_01385 4.43e-61 195.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2VQI2@28216|Betaproteobacteria,2KW4F@206389|Rhodocyclales 206389|Rhodocyclales I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_183072_1 1121937.AUHJ01000004_gene1117 7.48e-47 165.0 COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,4669T@72275|Alteromonadaceae 1236|Gammaproteobacteria S membrane rbn - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_867016_1 710421.Mycch_1081 0.000399 41.6 COG1545@1|root,COG1545@2|Bacteria,2II25@201174|Actinobacteria,23A1J@1762|Mycobacteriaceae 201174|Actinobacteria S nucleic-acid-binding protein containing a Zn-ribbon - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_867016_2 1121937.AUHJ01000041_gene283 9.94e-58 191.0 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,1RN81@1236|Gammaproteobacteria,46AFS@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG0183 Acetyl-CoA acetyltransferase - - - - - - - - - - - - Thiolase_C k59_1502890_1 1144307.PMI04_02922 6.6e-92 286.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria 28211|Alphaproteobacteria EQ N-methylhydantoinase B acetone carboxylase alpha subunit - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_1502890_2 1278078.G419_02400 1.37e-11 67.0 COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,4FXFM@85025|Nocardiaceae 201174|Actinobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_921561_1 330214.NIDE3574 9.91e-134 387.0 COG1509@1|root,COG1509@2|Bacteria,3J0W3@40117|Nitrospirae 40117|Nitrospirae C Lysine-2,3-aminomutase - - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - LAM_C,Radical_SAM k59_1504376_1 472759.Nhal_1217 1.11e-10 61.2 COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,1RN2Z@1236|Gammaproteobacteria,1X03U@135613|Chromatiales 135613|Chromatiales C Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal - - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Glyoxalase,Glyoxalase_5 k59_867847_1 713586.KB900536_gene2406 1.02e-19 89.0 COG3087@1|root,COG3087@2|Bacteria,1RCC0@1224|Proteobacteria,1SBGX@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Sporulation related domain - - - - - - - - - - - - SPOR k59_1333626_1 1117108.PAALTS15_13057 8.14e-06 53.5 COG0500@1|root,COG2226@2|Bacteria,1UMZ4@1239|Firmicutes,4HXN3@91061|Bacilli,277NZ@186822|Paenibacillaceae 91061|Bacilli Q Methyltransferase small domain - - - - - - - - - - - - Methyltransf_23,Methyltransf_25 k59_554068_2 314285.KT71_07354 7.42e-44 163.0 COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,1S1Y5@1236|Gammaproteobacteria,1J7SC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_94521_1 221288.JH992901_gene4499 2.3e-21 97.4 COG2234@1|root,COG2234@2|Bacteria,1G163@1117|Cyanobacteria,1JJH4@1189|Stigonemataceae 1117|Cyanobacteria S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 k59_713204_1 690850.Desaf_2364 5.6e-26 110.0 28HC9@1|root,2Z7P5@2|Bacteria,1R4BH@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_241124_1 1267535.KB906767_gene4838 3.29e-08 60.1 COG0457@1|root,COG3119@1|root,COG0457@2|Bacteria,COG3119@2|Bacteria 2|Bacteria P arylsulfatase activity - - - - - - - - - - - - Sulfatase,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_1079501_1 272560.BPSL2976 3.67e-09 56.6 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2VHHC@28216|Betaproteobacteria,1K1AJ@119060|Burkholderiaceae 28216|Betaproteobacteria E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004764,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046417,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0055114,GO:0061458,GO:0071704,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_1079501_2 1260251.SPISAL_01320 8.83e-60 197.0 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria,1WVV8@135613|Chromatiales 135613|Chromatiales C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_94543_1 330214.NIDE0760 9.66e-85 262.0 COG0772@1|root,COG0772@2|Bacteria,3J0M8@40117|Nitrospirae 40117|Nitrospirae D Cell cycle protein ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_1240032_1 1298593.TOL_0794 1.74e-61 199.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1XIB9@135619|Oceanospirillales 135619|Oceanospirillales J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_1389098_2 1121440.AUMA01000005_gene2554 2.32e-57 191.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,42R4A@68525|delta/epsilon subdivisions,2WM9Z@28221|Deltaproteobacteria,2M9TM@213115|Desulfovibrionales 28221|Deltaproteobacteria K PFAM Silent information regulator protein Sir2 - - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_453874_1 570268.ANBB01000041_gene1710 1.25e-69 219.0 COG1028@1|root,COG1028@2|Bacteria,2GMAG@201174|Actinobacteria,4EK3C@85012|Streptosporangiales 201174|Actinobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_1240033_1 1123070.KB899269_gene2392 7.13e-34 129.0 COG0480@1|root,COG0480@2|Bacteria,46TP0@74201|Verrucomicrobia,2IU37@203494|Verrucomicrobiae 203494|Verrucomicrobiae J Elongation factor G, domain IV - - - - - - - - - - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1389102_1 1449058.JQKT01000009_gene255 1.52e-21 98.6 COG1053@1|root,COG1053@2|Bacteria,2GIXG@201174|Actinobacteria,4FQ8Y@85023|Microbacteriaceae 201174|Actinobacteria C FAD binding domain - - - - - - - - - - - - FAD_binding_2 k59_15919_2 584708.Apau_0927 8.78e-37 139.0 COG0209@1|root,COG0209@2|Bacteria,3TAE6@508458|Synergistetes 508458|Synergistetes F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_669833_1 863365.XHC_0163 1.4e-34 136.0 COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB glgE - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3416 k59_713231_1 436308.Nmar_0075 1.26e-35 134.0 COG1287@1|root,arCOG02044@2157|Archaea,41SBI@651137|Thaumarchaeota 651137|Thaumarchaeota G Oligosaccharyl transferase STT3 subunit - - 2.4.99.18 ko:K07151 ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141 M00072 R04216,R05976 RC00005,RC00482 ko00000,ko00001,ko00002,ko01000,ko01003 - GT66 - STT3 k59_713231_2 436308.Nmar_0074 1.94e-35 124.0 COG1881@1|root,arCOG04702@2157|Archaea,41T4M@651137|Thaumarchaeota 651137|Thaumarchaeota S Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_1504450_1 330214.NIDE3561 3e-99 291.0 COG3748@1|root,COG3748@2|Bacteria,3J19B@40117|Nitrospirae 40117|Nitrospirae S Pfam:DUF989 - - - - - - - - - - - - Urate_ox_N k59_295909_1 314278.NB231_03747 3.42e-167 488.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales 135613|Chromatiales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_1538904_2 1280952.HJA_06512 1.55e-54 188.0 COG0318@1|root,COG0318@2|Bacteria,1MVJ1@1224|Proteobacteria,2TUQ9@28211|Alphaproteobacteria,43ZAH@69657|Hyphomonadaceae 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.42 ko:K00666,ko:K18688 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1024225_1 1415755.JQLV01000001_gene3249 1.67e-73 231.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,1RMH5@1236|Gammaproteobacteria,1XHZF@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the arginase family - - 3.5.3.11,3.5.3.17 ko:K01480,ko:K18459 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_713245_1 314275.MADE_000001022515 1.33e-29 125.0 COG0749@1|root,COG0749@2|Bacteria,1MWX7@1224|Proteobacteria,1S0Q1@1236|Gammaproteobacteria 1236|Gammaproteobacteria L ORF located using Glimmer RBSfinder - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A,DNA_pol_A_exo1 k59_1538912_1 485913.Krac_2355 3e-84 261.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2G9RC@200795|Chloroflexi 200795|Chloroflexi L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 k59_348058_2 379066.GAU_1711 4.39e-09 63.2 COG1253@1|root,COG1253@2|Bacteria,1ZTJW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function DUF21 - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,DUF21 k59_1657738_1 1254432.SCE1572_20250 6.83e-17 85.5 COG0559@1|root,COG0683@1|root,COG0559@2|Bacteria,COG0683@2|Bacteria,1N5XH@1224|Proteobacteria,42PN7@68525|delta/epsilon subdivisions,2WIRP@28221|Deltaproteobacteria,2Z0ZI@29|Myxococcales 28221|Deltaproteobacteria U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997,ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1151763_1 1123248.KB893314_gene3562 2.19e-104 322.0 COG1030@1|root,COG1030@2|Bacteria,4NGGV@976|Bacteroidetes,1IPJY@117747|Sphingobacteriia 976|Bacteroidetes O NfeD-like C-terminal, partner-binding - - - ko:K07403 - - - - ko00000 - - - CLP_protease,NfeD k59_1151763_2 436114.SYO3AOP1_0786 1.01e-22 95.5 COG0330@1|root,COG0330@2|Bacteria,2G4JQ@200783|Aquificae 200783|Aquificae O prohibitin homologues - - - - - - - - - - - - Band_7 k59_682552_1 1229909.NSED_09905 4.78e-74 242.0 COG1293@1|root,arCOG01695@2157|Archaea,41SB0@651137|Thaumarchaeota 651137|Thaumarchaeota K Fibronectin-binding protein A N-terminus (FbpA) - - - - - - - - - - - - DUF814,FbpA k59_838640_1 511.JT27_12325 2.62e-20 93.2 COG4948@1|root,COG4948@2|Bacteria,1R85F@1224|Proteobacteria,2W04F@28216|Betaproteobacteria,3T8TH@506|Alcaligenaceae 28216|Betaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_838640_2 1381123.AYOD01000008_gene3302 7.11e-13 72.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,43H3A@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O Belongs to the peptidase S1C family dop GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1361062_1 472759.Nhal_0207 1.02e-52 176.0 COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria,1X286@135613|Chromatiales 135613|Chromatiales C Oxidoreductase FAD-binding domain - - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind k59_942784_2 1123320.KB889747_gene7192 1.01e-37 140.0 COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria 201174|Actinobacteria IQ synthetase fadD19 GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009605,GO:0009607,GO:0009987,GO:0015645,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019752,GO:0030312,GO:0032787,GO:0042546,GO:0042579,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051087,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071554,GO:0071704,GO:0071766,GO:0071840,GO:0071944,GO:0075136,GO:1901576 6.2.1.42 ko:K00666,ko:K18688 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_316436_1 251229.Chro_4650 7.69e-54 187.0 COG0531@1|root,COG0531@2|Bacteria,1G2GM@1117|Cyanobacteria,3VINB@52604|Pleurocapsales 1117|Cyanobacteria E Amino acid polyamine organocation transporter, APC superfamily - - - - - - - - - - - - - k59_368622_1 292459.STH2824 1.52e-81 251.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia 186801|Clostridia P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_786989_1 472759.Nhal_1120 1.21e-40 149.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1WXPB@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_786989_2 472759.Nhal_1119 1.55e-27 106.0 COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1WYJU@135613|Chromatiales 135613|Chromatiales S Modulates RecA activity recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX k59_786989_3 292415.Tbd_2197 6.64e-183 517.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2VHNA@28216|Betaproteobacteria,1KRHR@119069|Hydrogenophilales 119069|Hydrogenophilales L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_786989_4 332101.JIBU02000051_gene3405 3.55e-73 227.0 COG3647@1|root,COG3647@2|Bacteria,1V19Q@1239|Firmicutes,249U7@186801|Clostridia,36DSZ@31979|Clostridiaceae 186801|Clostridia S Predicted membrane protein (DUF2238) - - - ko:K08984 - - - - ko00000 - - - DUF2238 k59_1569622_1 644282.Deba_2031 4.94e-72 228.0 COG3049@1|root,COG3049@2|Bacteria,1MWPQ@1224|Proteobacteria,42QQ7@68525|delta/epsilon subdivisions,2WN8Z@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Linear amide C-N hydrolases, choloylglycine hydrolase family - - 3.5.1.24 ko:K01442 ko00120,ko00121,ko01100,map00120,map00121,map01100 - R02797,R03975,R03977,R04486,R04487,R05835 RC00090,RC00096 ko00000,ko00001,ko01000 - - - CBAH k59_630358_1 1297581.H919_09307 2.36e-51 186.0 COG1165@1|root,COG1165@2|Bacteria,1TRDB@1239|Firmicutes,4HC48@91061|Bacilli,21V2F@150247|Anoxybacillus 91061|Bacilli H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) menD - 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS05085 TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N k59_682570_1 436308.Nmar_0322 1.22e-10 61.2 COG2038@1|root,arCOG04272@2157|Archaea,41SD3@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the UPF0284 family - - - - - - - - - - - - DBI_PRT k59_682570_2 436308.Nmar_0321 9.8e-75 228.0 arCOG00517@1|root,arCOG00517@2157|Archaea,41SHJ@651137|Thaumarchaeota 651137|Thaumarchaeota S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_158653_1 1151061.CAJY01000032_gene2205 3.89e-23 101.0 COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria 201174|Actinobacteria I Belongs to the thiolase family ltp1 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N k59_682573_2 1123296.JQKE01000058_gene1400 9.66e-35 125.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,2KPUH@206351|Neisseriales 206351|Neisseriales L hydrolase, TatD family ycfH - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_55757_1 225937.HP15_749 1.38e-43 153.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RNPX@1236|Gammaproteobacteria,464Y1@72275|Alteromonadaceae 1236|Gammaproteobacteria P Belongs to the ABC transporter superfamily fbpC - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 k59_108081_2 933262.AXAM01000022_gene3238 1.77e-51 177.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,42P6I@68525|delta/epsilon subdivisions,2WMAF@28221|Deltaproteobacteria,2MIAS@213118|Desulfobacterales 28221|Deltaproteobacteria HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k59_943921_1 667632.KB890165_gene2616 4.13e-18 84.3 COG4339@1|root,COG4339@2|Bacteria,1MZ9X@1224|Proteobacteria,2VRYZ@28216|Betaproteobacteria,1K7AP@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_839824_1 426114.THI_2616 2.18e-19 94.0 COG0251@1|root,COG0251@2|Bacteria,1NQGP@1224|Proteobacteria,2VMPK@28216|Betaproteobacteria,1KKUK@119065|unclassified Burkholderiales 28216|Betaproteobacteria J pteridine-dependent deoxygenase - - - - - - - - - - - - Ribonuc_L-PSP k59_839824_2 1158756.AQXQ01000012_gene1695 4.19e-05 44.3 COG0236@1|root,COG0236@2|Bacteria,1N6RU@1224|Proteobacteria,1SCW1@1236|Gammaproteobacteria,1WZ77@135613|Chromatiales 135613|Chromatiales IQ Phosphopantetheine attachment site - - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_735302_1 745014.OMB55_00011440 1.8e-294 826.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,1RZZE@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the GcvT family - - - - - - - - - - - - DAO,FAO_M,GCV_T,GCV_T_C k59_1153057_2 933262.AXAM01000020_gene28 5.03e-16 76.3 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,42TV9@68525|delta/epsilon subdivisions,2WNAN@28221|Deltaproteobacteria,2MK10@213118|Desulfobacterales 28221|Deltaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_159472_1 420662.Mpe_A1917 2.11e-24 103.0 COG0697@1|root,COG0697@2|Bacteria,1RFZW@1224|Proteobacteria,2VJS5@28216|Betaproteobacteria,1KJ5V@119065|unclassified Burkholderiales 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_473833_1 634956.Geoth_0671 8.79e-21 101.0 COG2271@1|root,COG2271@2|Bacteria,1TP6X@1239|Firmicutes,4HEVA@91061|Bacilli,1WENC@129337|Geobacillus 91061|Bacilli G Major Facilitator Superfamily gudP GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - ko:K03535,ko:K08191,ko:K08194 - - - - ko00000,ko02000 2.A.1.14.1,2.A.1.14.2,2.A.1.14.7 - iYO844.BSU02480 MFS_1 k59_1466862_1 331869.BAL199_20520 8.2e-180 513.0 COG0665@1|root,COG0665@2|Bacteria,1PERE@1224|Proteobacteria,2U1FT@28211|Alphaproteobacteria 28211|Alphaproteobacteria E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_1206400_1 1415780.JPOG01000001_gene2959 1.26e-35 136.0 COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,1RR1C@1236|Gammaproteobacteria,1X57A@135614|Xanthomonadales 135614|Xanthomonadales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1517574_1 316067.Geob_1475 2.01e-27 116.0 COG4641@1|root,COG4641@2|Bacteria 2|Bacteria M Protein conserved in bacteria - - - ko:K06320 - - - - ko00000 - - - DUF3880,Glyco_trans_1_2 k59_57189_1 1206735.BAGG01000092_gene3710 2.21e-52 181.0 COG1012@1|root,COG1012@2|Bacteria,2GJ95@201174|Actinobacteria,4FWXS@85025|Nocardiaceae 201174|Actinobacteria C Aldehyde dehydrogenase family - - 1.2.99.10 ko:K22445 - - - - ko00000,ko01000 - - - Aldedh k59_369749_1 1239962.C943_02005 1.73e-64 202.0 COG1335@1|root,COG1335@2|Bacteria,4NKPP@976|Bacteroidetes,47PIR@768503|Cytophagia 976|Bacteroidetes Q Isochorismatase family pncA - 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 - R01268 RC00100 ko00000,ko00001,ko01000 - - - Isochorismatase k59_369749_2 1144305.PMI02_03531 7.03e-10 64.7 COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,2U1UW@28211|Alphaproteobacteria,2KDB4@204457|Sphingomonadales 204457|Sphingomonadales S Alkaline phosphatase with broad substrate specificity - - - - - - - - - - - - Phosphodiest k59_735311_1 330214.NIDE0356 6.55e-146 429.0 COG0166@1|root,COG0166@2|Bacteria 2|Bacteria G Belongs to the GPI family tal - 2.2.1.2,5.3.1.9 ko:K01810,ko:K13810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00004,M00007,M00114 R01827,R02739,R02740,R03321 RC00376,RC00439,RC00563,RC00604 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI,TAL_FSA k59_578599_1 1205680.CAKO01000038_gene1776 3.65e-08 55.1 COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2TVBB@28211|Alphaproteobacteria,2JZCU@204441|Rhodospirillales 204441|Rhodospirillales I Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_892226_1 765913.ThidrDRAFT_1741 1.85e-51 163.0 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,1S5VT@1236|Gammaproteobacteria,1WYHJ@135613|Chromatiales 135613|Chromatiales J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_892226_2 1049564.TevJSym_aa00070 2.64e-47 154.0 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria,1J668@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_473855_1 309801.trd_A0752 4.06e-104 320.0 COG0001@1|root,COG0001@2|Bacteria,2G67D@200795|Chloroflexi,27XJ3@189775|Thermomicrobia 189775|Thermomicrobia H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_57209_1 640512.BC1003_4746 2.43e-49 168.0 COG2187@1|root,COG2187@2|Bacteria,1R98V@1224|Proteobacteria,2VM22@28216|Betaproteobacteria,1K6U0@119060|Burkholderiaceae 28216|Betaproteobacteria S AAA domain - - - - - - - - - - - - - k59_317790_2 1123058.KB894219_gene166 2.03e-16 77.0 2CC49@1|root,33MRB@2|Bacteria,4P8SJ@976|Bacteroidetes 976|Bacteroidetes S Protein of unknown function (DUF1367) - - - - - - - - - - - - DUF1367 k59_526304_1 1229909.NSED_03500 1.78e-112 329.0 COG0031@1|root,arCOG01430@2157|Archaea,41SYM@651137|Thaumarchaeota 651137|Thaumarchaeota E Cysteine synthase - - 2.5.1.47 ko:K12339 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03132,R03601,R04859 RC00020,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_684009_1 525904.Tter_2623 6.05e-145 435.0 COG1060@1|root,COG1060@2|Bacteria,2NP8W@2323|unclassified Bacteria 2|Bacteria H Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) fbiC - 1.21.98.1,2.5.1.77 ko:K11779,ko:K11784 ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120 M00378 R08588,R09396 RC01381,RC02329,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - CofC,Radical_SAM k59_684009_2 426716.JOAJ01000010_gene6305 1.49e-05 47.4 COG1023@1|root,COG1023@2|Bacteria,2I2DH@201174|Actinobacteria,4FX34@85025|Nocardiaceae 201174|Actinobacteria G Protein involved in phosphogluconate dehydrogenase (decarboxylating) activity, 3-hydroxyisobutyrate dehydrogenase activity, NADP binding, valine metabolism, pentose-phosphate shunt, oxidative branch and D-gluconate metabolism gnd2 - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv1122 6PGD,NAD_binding_2 k59_788506_2 1379270.AUXF01000006_gene291 3.27e-37 140.0 COG0728@1|root,COG0728@2|Bacteria,1ZTCM@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_1466895_1 1027273.GZ77_21965 1.72e-84 258.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1XH68@135619|Oceanospirillales 135619|Oceanospirillales C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_57215_1 502025.Hoch_3377 2.51e-27 109.0 COG0842@1|root,COG0842@2|Bacteria,1NRMT@1224|Proteobacteria,43B3S@68525|delta/epsilon subdivisions,2X6HQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_57215_2 130081.XP_005705716.1 2.99e-46 176.0 COG3670@1|root,KOG1285@2759|Eukaryota 2759|Eukaryota Q oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen - - - - - - - - - - - - RPE65 k59_1414216_1 402777.KB235904_gene3191 9.73e-63 194.0 COG0745@1|root,COG0745@2|Bacteria,1G6W5@1117|Cyanobacteria,1HBXB@1150|Oscillatoriales 1117|Cyanobacteria T Response regulator receiver - - - - - - - - - - - - Response_reg k59_1414216_2 1173027.Mic7113_4161 2.47e-32 127.0 COG2199@1|root,COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1GQ1T@1117|Cyanobacteria,1HHSH@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,Response_reg k59_1309702_1 436308.Nmar_0067 7.35e-112 348.0 COG1615@1|root,arCOG06128@2157|Archaea,41SCS@651137|Thaumarchaeota 651137|Thaumarchaeota S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 k59_57218_2 757424.Hsero_3670 1.43e-16 81.3 28HK0@1|root,2Z7V0@2|Bacteria,1MXSJ@1224|Proteobacteria,2VKGU@28216|Betaproteobacteria,473YJ@75682|Oxalobacteraceae 28216|Betaproteobacteria S Domain of unknown function (DUF4105) - - - - - - - - - - - - DUF4105 k59_631872_1 1380763.BG53_06480 3.53e-25 115.0 COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,4H9NB@91061|Bacilli,26QY4@186822|Paenibacillaceae 91061|Bacilli L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_317802_1 1493509.A0A0E3ENJ1_9CAUD 7.15e-17 73.6 4QBUS@10239|Viruses,4QRU0@28883|Caudovirales,4QIXD@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_317802_2 167555.NATL1_08521 1.88e-05 44.7 2A5GF@1|root,30U6G@2|Bacteria,1GP2X@1117|Cyanobacteria,1MMXT@1212|Prochloraceae 1117|Cyanobacteria S Alternative locus ID - - - - - - - - - - - - - k59_421995_1 765912.Thimo_3431 3.8e-83 253.0 COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,1RYEC@1236|Gammaproteobacteria,1WW38@135613|Chromatiales 135613|Chromatiales P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_1309706_1 1121015.N789_07360 5.41e-104 338.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1X465@135614|Xanthomonadales 135614|Xanthomonadales E Glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_735344_2 330214.NIDE0325 8.36e-72 229.0 COG1236@1|root,COG1236@2|Bacteria,3J0FD@40117|Nitrospirae 40117|Nitrospirae J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_526318_1 1229485.AMYV01000063_gene3261 5.14e-103 311.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1J4PI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the GARS family purD GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 ko:K01945,ko:K13713 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729 GARS_A,GARS_C,GARS_N k59_1101165_1 1173027.Mic7113_0671 2.02e-59 194.0 COG4360@1|root,COG4360@2|Bacteria,1G2S9@1117|Cyanobacteria,1H6XH@1150|Oscillatoriales 1117|Cyanobacteria F ATP adenylyltransferase apa2 - 2.7.7.53 ko:K00988 ko00230,map00230 - R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 - - - ATP_transf k59_422000_1 396588.Tgr7_1034 2.08e-15 76.3 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1WWPS@135613|Chromatiales 135613|Chromatiales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_482924_1 1200557.JHWV01000006_gene1677 0.000588 49.7 COG2159@1|root,COG2159@2|Bacteria 2|Bacteria E amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_798884_1 1384056.N787_11800 1.24e-40 146.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1X2ZK@135614|Xanthomonadales 135614|Xanthomonadales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e k59_798884_2 1121904.ARBP01000011_gene1507 0.000326 44.7 2E047@1|root,2ZJQK@2|Bacteria,4P6XA@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_482930_1 562970.Btus_2268 3.26e-51 175.0 COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,4H9VZ@91061|Bacilli,2785B@186823|Alicyclobacillaceae 91061|Bacilli E Aminotransferase class-III argD - 2.6.1.11,2.6.1.13,2.6.1.17 ko:K00819,ko:K00821 ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R00667,R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1423130_1 330214.NIDE1378 4.99e-174 498.0 COG0459@1|root,COG0459@2|Bacteria,3J0DA@40117|Nitrospirae 40117|Nitrospirae O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1268618_1 653948.CCA23067 8.76e-31 125.0 COG0523@1|root,COG1073@1|root,KOG2743@2759|Eukaryota,KOG4391@2759|Eukaryota 2759|Eukaryota O protein depalmitoylation CBWD1 GO:0000322,GO:0000323,GO:0000324,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005773,GO:0005783,GO:0005886,GO:0007275,GO:0008150,GO:0012505,GO:0016020,GO:0016787,GO:0016788,GO:0019866,GO:0022622,GO:0031090,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0048364,GO:0048731,GO:0048856,GO:0071944,GO:0099402 - ko:K06889,ko:K12605 ko03018,map03018 - - - ko00000,ko00001,ko03019 - - - CobW_C,Hydrolase_4,cobW k59_166414_1 1026882.MAMP_01367 6.64e-30 123.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,45ZWF@72273|Thiotrichales 72273|Thiotrichales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_1476662_2 269799.Gmet_1284 2.08e-39 139.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,42SJW@68525|delta/epsilon subdivisions,2WPF7@28221|Deltaproteobacteria,43TY8@69541|Desulfuromonadales 28221|Deltaproteobacteria J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase hpf - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosom_S30AE_C,Ribosomal_S30AE k59_67340_1 641526.ADIWIN_2822 3.71e-23 101.0 COG1226@1|root,COG1226@2|Bacteria,4NG7W@976|Bacteroidetes,1HXU2@117743|Flavobacteriia 976|Bacteroidetes P K transport - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_C,TrkA_N k59_1109044_1 395493.BegalDRAFT_2465 1.83e-22 100.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,45ZRN@72273|Thiotrichales 72273|Thiotrichales O Peptidylprolyl isomerase - - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_220819_1 1541065.JRFE01000001_gene2582 1.09e-61 205.0 COG1301@1|root,COG1301@2|Bacteria,1G32C@1117|Cyanobacteria,3VN2Y@52604|Pleurocapsales 1117|Cyanobacteria C Sodium:dicarboxylate symporter family - - - ko:K03309 - - - - ko00000 2.A.23 - - SDF k59_1578368_1 521719.ATXQ01000001_gene415 5.64e-35 137.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1YE64@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1522717_1 1122135.KB893134_gene3970 7.35e-64 221.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2TTGI@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Major facilitator Superfamily aas - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_798914_1 436308.Nmar_1261 2.83e-61 200.0 COG0621@1|root,arCOG01358@2157|Archaea,41SB9@651137|Thaumarchaeota 651137|Thaumarchaeota J MiaB-like tRNA modifying enzyme - - 2.8.4.5 ko:K15865 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 k59_798914_2 436308.Nmar_1262 1.12e-19 86.7 COG0206@1|root,arCOG02201@2157|Archaea,41SG8@651137|Thaumarchaeota 651137|Thaumarchaeota D Tubulin/FtsZ family, GTPase domain - - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - Tubulin k59_533950_1 1049564.TevJSym_au00590 6e-27 105.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1J5GV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0030091,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_1631448_1 247639.MGP2080_01661 9.64e-34 122.0 COG1545@1|root,COG1545@2|Bacteria,1N7HH@1224|Proteobacteria,1SY5W@1236|Gammaproteobacteria,1JBBQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Rubredoxin-like zinc ribbon domain (DUF35_N) - - - - - - - - - - - - DUF35_N,OB_aCoA_assoc k59_1631448_2 228405.HNE_0843 6.47e-17 79.7 COG2030@1|root,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2U5CQ@28211|Alphaproteobacteria,43XTT@69657|Hyphomonadaceae 28211|Alphaproteobacteria I dehydratase - GO:0003674,GO:0003824,GO:0003859,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044281,GO:0046487,GO:0071704 4.2.1.55 ko:K17865 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R03027 RC00831 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydratas k59_67352_1 340177.Cag_2010 5.19e-31 123.0 COG0477@1|root,COG2814@2|Bacteria,1FDXJ@1090|Chlorobi 1090|Chlorobi EGP major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_3 k59_1215890_1 489825.LYNGBM3L_63500 1.36e-51 181.0 COG5421@1|root,COG5421@2|Bacteria,1G3YW@1117|Cyanobacteria,1HHRP@1150|Oscillatoriales 1117|Cyanobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1 k59_67360_1 1408473.JHXO01000005_gene1505 6.17e-32 126.0 COG1253@1|root,COG1253@2|Bacteria,4NDZ7@976|Bacteroidetes,2FMEZ@200643|Bacteroidia 976|Bacteroidetes S gliding motility-associated protein GldE gldE - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1423165_1 1030157.AFMP01000062_gene3598 8.22e-26 101.0 COG0251@1|root,COG0251@2|Bacteria,1Q868@1224|Proteobacteria,2VEC6@28211|Alphaproteobacteria,2K7HM@204457|Sphingomonadales 204457|Sphingomonadales J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_1268657_1 1121116.KB894771_gene1517 6.06e-12 72.4 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2VPD5@28216|Betaproteobacteria,4AE9K@80864|Comamonadaceae 28216|Betaproteobacteria C Cytochrome P450 bioI - - - - - - - - - - - p450 k59_1369888_1 481448.Minf_1647 8.18e-26 98.2 2DBJQ@1|root,32TXM@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Pyr_excise k59_1369888_2 237368.SCABRO_02094 2.22e-30 117.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria 2|Bacteria L Protein of unknown function (DUF1722) ybgA - - - - - - - - - - - DUF1722,DUF523 k59_1056815_1 1123400.KB904817_gene1474 2.17e-40 135.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,1S973@1236|Gammaproteobacteria,460ZF@72273|Thiotrichales 72273|Thiotrichales J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_1056815_2 765910.MARPU_03780 1.98e-87 261.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,1WW32@135613|Chromatiales 135613|Chromatiales J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_1056815_3 1198232.CYCME_0758 5.38e-08 51.2 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,1S62N@1236|Gammaproteobacteria,460WT@72273|Thiotrichales 72273|Thiotrichales J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_166448_1 519989.ECTPHS_08226 2.94e-73 234.0 COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,1RMGC@1236|Gammaproteobacteria,1WWQU@135613|Chromatiales 135613|Chromatiales E Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B k59_115651_1 765910.MARPU_04180 7.05e-62 204.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1WXC2@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_115651_2 1122194.AUHU01000008_gene3406 3.94e-07 50.8 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,464GU@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0569 K transport systems, NAD-binding component trkA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0015075,GO:0015672,GO:0016020,GO:0022857,GO:0030001,GO:0034220,GO:0051179,GO:0051234,GO:0055085,GO:0098655 - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - iE2348C_1286.E2348C_3552 TrkA_C,TrkA_N k59_1369892_1 443152.MDG893_18979 3.85e-42 149.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,1RQ5E@1236|Gammaproteobacteria,466CU@72275|Alteromonadaceae 1236|Gammaproteobacteria NT COG1352 Methylase of chemotaxis methyl-accepting proteins pilK - 2.1.1.80 ko:K00575,ko:K02661 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035,ko02044 - - - CheR,CheR_N k59_1578400_1 1227360.C176_09752 2.93e-15 75.5 COG1028@1|root,COG1028@2|Bacteria,1U2GS@1239|Firmicutes,4H9R9@91061|Bacilli,26EIW@186818|Planococcaceae 91061|Bacilli IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_641953_2 1121935.AQXX01000005_gene681 7.49e-34 121.0 2CJPW@1|root,32SAH@2|Bacteria,1NAJ3@1224|Proteobacteria,1SAPE@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_641953_3 1448389.BAVQ01000002_gene2954 3.15e-05 45.4 COG0365@1|root,COG0365@2|Bacteria,2GJVK@201174|Actinobacteria 201174|Actinobacteria I Acyl-coenzyme A synthetases AMP-(fatty) acid ligases - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1522734_1 444860.E3SIR0_9CAUD 1.15e-80 254.0 4QEKP@10239|Viruses,4QXCW@35237|dsDNA viruses no RNA stage,4QUCM@28883|Caudovirales,4QI72@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_900124_1 1340493.JNIF01000003_gene2911 7.49e-05 52.4 COG5555@1|root,COG5555@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Metallophos k59_1109096_1 378753.KRH_22390 8.71e-10 65.5 COG4221@1|root,COG4221@2|Bacteria,2I2SK@201174|Actinobacteria,1WAWH@1268|Micrococcaceae 201174|Actinobacteria S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short,adh_short_C2 k59_798973_1 870187.Thini_1724 5.88e-95 301.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,460C5@72273|Thiotrichales 72273|Thiotrichales I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ACBP,ECH_1 k59_67404_1 1335757.SPICUR_01540 7.39e-41 153.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1578426_1 316067.Geob_1021 9.57e-12 64.3 COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,42PRT@68525|delta/epsilon subdivisions,2WIWH@28221|Deltaproteobacteria,43U6B@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2638 PEPCK_C,PEPCK_N k59_1578426_2 592015.HMPREF1705_00485 2.11e-07 53.5 COG0205@1|root,COG0205@2|Bacteria,3TAHJ@508458|Synergistetes 508458|Synergistetes H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_742942_1 56780.SYN_00391 6.62e-39 139.0 COG1879@1|root,COG1879@2|Bacteria,1R8FV@1224|Proteobacteria 1224|Proteobacteria G Periplasmic binding protein domain - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_742942_2 1496688.ER33_13375 1.34e-45 150.0 COG0412@1|root,COG0412@2|Bacteria 2|Bacteria Q carboxymethylenebutenolidase activity M1-673 - 3.1.1.45 ko:K01061,ko:K07017 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_67410_1 187272.Mlg_2079 6.11e-104 317.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WXAR@135613|Chromatiales 135613|Chromatiales NU TIGRFAM type IV-A pilus assembly ATPase PilB - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_67411_1 104355.XP_007865260.1 9.67e-19 81.3 COG0278@1|root,KOG0911@2759|Eukaryota,3A1XT@33154|Opisthokonta,3P2U5@4751|Fungi,3V1AG@5204|Basidiomycota,229KK@155619|Agaricomycetes,3H523@355688|Agaricomycetes incertae sedis 4751|Fungi O Glutaredoxin GRX5 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006790,GO:0006807,GO:0006950,GO:0006970,GO:0006979,GO:0008150,GO:0008152,GO:0009628,GO:0009987,GO:0010467,GO:0015035,GO:0015036,GO:0015037,GO:0015038,GO:0016043,GO:0016226,GO:0016491,GO:0016667,GO:0016740,GO:0016782,GO:0019538,GO:0022607,GO:0031163,GO:0031974,GO:0033554,GO:0034599,GO:0036455,GO:0042221,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044571,GO:0044572,GO:0048037,GO:0050896,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0051716,GO:0055114,GO:0070013,GO:0070887,GO:0071704,GO:0071840,GO:0097428,GO:0106034,GO:1901564 - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin k59_1160297_1 314230.DSM3645_23671 2.77e-46 168.0 COG0840@1|root,COG2202@1|root,COG0840@2|Bacteria,COG2202@2|Bacteria,2IXQA@203682|Planctomycetes 203682|Planctomycetes NT Methyl-accepting chemotaxis protein (MCP) signaling domain - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PAS_4,PAS_9 k59_534001_1 868131.MSWAN_1957 1.13e-13 74.7 COG0111@1|root,COG2150@1|root,arCOG01754@2157|Archaea,arCOG02316@2157|Archaea,2XU9V@28890|Euryarchaeota,23NQM@183925|Methanobacteria 183925|Methanobacteria E D-isomer specific 2-hydroxyacid dehydrogenase serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_534001_2 1144275.COCOR_05424 1.15e-123 368.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2WJ3F@28221|Deltaproteobacteria,2YUGA@29|Myxococcales 28221|Deltaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_534849_1 1121472.AQWN01000007_gene1136 3.26e-95 297.0 COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24DPN@186801|Clostridia,260G2@186807|Peptococcaceae 186801|Clostridia I TIGRFAM Acetoacetyl-CoA synthase - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1632346_1 1049564.TevJSym_ap00260 4.54e-77 250.0 COG0637@1|root,COG1234@1|root,COG0637@2|Bacteria,COG1234@2|Bacteria,1PPRD@1224|Proteobacteria,1RRV8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Beta-lactamase superfamily domain rnz - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - CLP1_P,Lactamase_B,Lactamase_B_2 k59_1057603_2 684719.HIMB114_00013450 1.62e-68 222.0 COG1840@1|root,COG1840@2|Bacteria,1MWWI@1224|Proteobacteria,2VF0S@28211|Alphaproteobacteria,4BTD5@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_6 k59_68413_2 314285.KT71_14824 5.1e-18 85.5 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1J60U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_378729_1 1131269.AQVV01000002_gene1209 3.69e-34 126.0 COG1533@1|root,COG1533@2|Bacteria 2|Bacteria L DNA photolyase activity - - - - - - - - - - - - Radical_SAM k59_378729_2 656024.FsymDg_0530 2.51e-39 137.0 COG0346@1|root,COG0346@2|Bacteria,2IFUM@201174|Actinobacteria,4EVK6@85013|Frankiales 201174|Actinobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase cadI GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896 - - - - - - - - - - Glyoxalase k59_484150_1 330214.NIDE4332 1.12e-97 288.0 COG1704@1|root,COG1704@2|Bacteria 2|Bacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_743749_1 330214.NIDE2440 5.37e-54 196.0 COG0667@1|root,COG1331@1|root,COG0667@2|Bacteria,COG1331@2|Bacteria,3J0HX@40117|Nitrospirae 40117|Nitrospirae O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_279952_1 436308.Nmar_0625 3.41e-84 253.0 COG1920@1|root,arCOG04472@2157|Archaea,41SPV@651137|Thaumarchaeota 651137|Thaumarchaeota H Guanylyl transferase CofC like - - 2.7.7.68 ko:K14941 ko00680,ko01120,map00680,map01120 M00378 R09397 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CofC k59_1115474_1 743299.Acife_0699 2.27e-72 224.0 COG2132@1|root,COG2132@2|Bacteria,1QUX3@1224|Proteobacteria,1S6MG@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Domain of unknown function (DUF4396) - - - - - - - - - - - - DUF4396 k59_1115474_2 298386.PBPRA2248 7.45e-18 76.6 COG0526@1|root,COG0526@2|Bacteria,1NC2Q@1224|Proteobacteria 1224|Proteobacteria CO Thioredoxin domain - - - - - - - - - - - - Thioredoxin_3 k59_592836_1 443144.GM21_3322 4.55e-104 306.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,42N5W@68525|delta/epsilon subdivisions,2WIU3@28221|Deltaproteobacteria,43T5Z@69541|Desulfuromonadales 28221|Deltaproteobacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_386349_1 694431.DESACE_08855 1.03e-20 90.5 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2WQGI@28221|Deltaproteobacteria,2M799@213113|Desulfurellales 28221|Deltaproteobacteria O FKBP-type peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - FKBP_C k59_75865_1 269796.Rru_A2910 5.24e-12 73.9 COG1463@1|root,COG1463@2|Bacteria,1RCV1@1224|Proteobacteria,2U6E9@28211|Alphaproteobacteria,2JRVS@204441|Rhodospirillales 204441|Rhodospirillales Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_906662_1 1137269.AZWL01000001_gene5825 1.46e-62 198.0 2AXQV@1|root,31PRS@2|Bacteria,2I93X@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - Polyketide_cyc2 k59_1321760_1 1137745.H6WFR9_9CAUD 1.61e-125 365.0 4QGYD@10239|Viruses,4QVN8@35237|dsDNA viruses no RNA stage,4QS47@28883|Caudovirales,4QJQ7@10662|Myoviridae 10662|Myoviridae S pentose-phosphate shunt - - - - - - - - - - - - - k59_807632_1 335543.Sfum_1227 7.62e-71 227.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2WIXI@28221|Deltaproteobacteria,2MQWA@213462|Syntrophobacterales 28221|Deltaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_386354_1 1288494.EBAPG3_21000 7.88e-94 290.0 COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VI20@28216|Betaproteobacteria,371MF@32003|Nitrosomonadales 28216|Betaproteobacteria P Binding-protein-dependent transport system inner membrane component fbpB - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_1431569_1 717231.Flexsi_0592 3.02e-56 196.0 COG1138@1|root,COG1138@2|Bacteria,2GEUI@200930|Deferribacteres 2|Bacteria O Cytochrome c-type biogenesis protein CcmF C-terminal ccmF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - ko:K02198,ko:K04016 - - R05712 RC00176 ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_1321762_1 1026882.MAMP_02431 4.25e-42 149.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,462DX@72273|Thiotrichales 72273|Thiotrichales M PFAM Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_1321762_2 287.DR97_4175 1.44e-10 63.2 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1S1A7@1236|Gammaproteobacteria,1YKNU@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T diguanylate cyclase wspR - 2.7.7.65,3.1.3.3 ko:K07315,ko:K11444 ko02020,ko02025,map02020,map02025 M00509 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko03021 - - - GGDEF,Response_reg k59_650538_1 396588.Tgr7_0989 1.53e-200 561.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_650538_2 1111732.AZOD01000013_gene1989 6.54e-16 74.3 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1X3TC@135614|Xanthomonadales 135614|Xanthomonadales C NADH dehydrogenase nuoE - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_172450_1 1232683.ADIMK_2146 1.41e-100 308.0 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,464SD@72275|Alteromonadaceae 1236|Gammaproteobacteria O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_957889_1 314278.NB231_05416 1.59e-51 181.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1WXUN@135613|Chromatiales 135613|Chromatiales P TrkA-C domain - - - - - - - - - - - - CitMHS,TrkA_C k59_1277506_1 1122947.FR7_0618 2.63e-05 51.6 COG1309@1|root,COG1309@2|Bacteria,1UWVP@1239|Firmicutes,4H8FR@909932|Negativicutes 909932|Negativicutes K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_650545_2 665571.STHERM_c16250 3.71e-39 139.0 COG0476@1|root,COG0476@2|Bacteria,2J75K@203691|Spirochaetes 203691|Spirochaetes H ThiF family - - - - - - - - - - - - ThiF k59_1277511_1 323261.Noc_2130 2.5e-55 194.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_1527297_1 1229909.NSED_09545 5.21e-20 89.0 COG1746@1|root,arCOG04249@2157|Archaea,41S76@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate cca - 2.7.7.72 ko:K07558 - - R09382,R09383,R09384,R09386 RC00078 ko00000,ko01000,ko03016 - - - NTP_transf_2,tRNA_NucTransf2 k59_1527297_2 521011.Mpal_0012 3.42e-23 96.7 COG1514@1|root,arCOG01736@2157|Archaea,2XZ2M@28890|Euryarchaeota,2N9X8@224756|Methanomicrobia 224756|Methanomicrobia J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester ligT - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase k59_1485234_2 1147094.H6X3J8_9CAUD 8.83e-36 137.0 4QDCA@10239|Viruses,4R046@35237|dsDNA viruses no RNA stage,4QQZY@28883|Caudovirales,4QIQA@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1321777_2 1283340.Q6WHK5_BPKVM 2.85e-11 67.8 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_1222977_1 243233.MCA0109 1.48e-64 202.0 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1XF1J@135618|Methylococcales 135618|Methylococcales H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB - 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_1222977_2 395493.BegalDRAFT_0223 4.27e-10 57.8 COG2921@1|root,COG2921@2|Bacteria,1NMJ1@1224|Proteobacteria,1SI79@1236|Gammaproteobacteria,461CF@72273|Thiotrichales 72273|Thiotrichales S Protein of unknown function (DUF493) - - - ko:K09158 - - - - ko00000 - - - DUF493 k59_1222977_3 228410.NE1486 4.34e-05 45.4 COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2VIVK@28216|Betaproteobacteria,3727J@32003|Nitrosomonadales 28216|Betaproteobacteria EH PFAM Aminotransferase, class IV dat - 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 k59_1277530_1 1521187.JPIM01000017_gene329 2.18e-16 83.6 COG4753@1|root,COG4963@1|root,COG4753@2|Bacteria,COG4963@2|Bacteria,2G6CH@200795|Chloroflexi,37524@32061|Chloroflexia 32061|Chloroflexia D PFAM response regulator receiver - - - ko:K02282 - - - - ko00000,ko02035,ko02044 - - - AAA_31,ParA,Response_reg k59_227233_1 686340.Metal_2132 4.73e-49 180.0 COG2373@1|root,COG3209@1|root,COG2373@2|Bacteria,COG3209@2|Bacteria,1QV7E@1224|Proteobacteria,1T3HZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M TIGRFAM Outer membrane protein - - - - - - - - - - - - - k59_1527305_1 717774.Marme_0478 8.51e-68 219.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1XHND@135619|Oceanospirillales 135619|Oceanospirillales M COG2230 Cyclopropane fatty acid synthase and related methyltransferases - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_436969_1 1196324.A374_17144 2.81e-24 95.1 COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,4HNNA@91061|Bacilli 91061|Bacilli J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_436969_2 643562.Daes_1040 5.1e-13 70.1 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42Q0K@68525|delta/epsilon subdivisions,2WJUW@28221|Deltaproteobacteria,2M8AC@213115|Desulfovibrionales 28221|Deltaproteobacteria L Belongs to the DEAD box helicase family dedA - 3.6.4.13 ko:K03732,ko:K05592 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_436973_1 1049564.TevJSym_av00160 1.21e-123 368.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria,1J4EK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG0008 Glutamyl- and glutaminyl-tRNA synthetases glnS GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECIAI39_1322.ECIAI39_0637 tRNA-synt_1c,tRNA-synt_1c_C k59_227239_1 396588.Tgr7_2400 5.25e-37 137.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,1RMMN@1236|Gammaproteobacteria,1WWWA@135613|Chromatiales 135613|Chromatiales M Sugar transferase - - - - - - - - - - - - Bac_transf,CoA_binding_3 k59_1222991_1 1122132.AQYH01000002_gene1445 7.09e-71 239.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,4B8NI@82115|Rhizobiaceae 28211|Alphaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_1376268_1 338969.Rfer_0062 6.4e-134 397.0 COG1960@1|root,COG1960@2|Bacteria,1R15B@1224|Proteobacteria 1224|Proteobacteria C acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_1277545_1 58344.JOEL01000023_gene1106 1.79e-49 171.0 COG2070@1|root,COG2070@2|Bacteria,2GKA6@201174|Actinobacteria 201174|Actinobacteria T 2-nitropropane dioxygenase fabK GO:0000166,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0007623,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0012505,GO:0016192,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032940,GO:0034404,GO:0034641,GO:0034654,GO:0034774,GO:0036094,GO:0036230,GO:0042119,GO:0042278,GO:0042451,GO:0042455,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046903,GO:0048511,GO:0050896,GO:0051179,GO:0051234,GO:0055086,GO:0055114,GO:0060205,GO:0070013,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097708,GO:0099503,GO:0101002,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:1904813 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_1376269_1 1419583.V466_03360 6.75e-69 234.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1YMUF@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria E dehydrogenase gdhB - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH,GDH_N k59_749453_1 491915.Aflv_1401 9.56e-77 234.0 COG1225@1|root,COG1225@2|Bacteria,1V058@1239|Firmicutes,4HE2H@91061|Bacilli,21VAG@150247|Anoxybacillus 91061|Bacilli O Redoxin - - - - - - - - - - - - AhpC-TSA,Redoxin k59_1063633_1 269796.Rru_A1104 2.67e-162 464.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2TSHT@28211|Alphaproteobacteria,2JPS4@204441|Rhodospirillales 204441|Rhodospirillales EH Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_124133_1 1038859.AXAU01000028_gene24 9.42e-88 266.0 COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2TTC6@28211|Alphaproteobacteria,3JSJ8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_906716_1 1123373.ATXI01000010_gene1017 4.72e-41 152.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2GHEJ@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_809043_2 1123073.KB899242_gene1402 1.13e-47 159.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,1X5IB@135614|Xanthomonadales 135614|Xanthomonadales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_333418_1 794846.AJQU01000045_gene4398 2.76e-32 116.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2TQZM@28211|Alphaproteobacteria,4BB0Q@82115|Rhizobiaceae 28211|Alphaproteobacteria C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_493063_1 706587.Desti_3199 1.76e-77 259.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_700387_1 479434.Sthe_3330 1.39e-26 110.0 COG1363@1|root,COG1363@2|Bacteria,2G6EE@200795|Chloroflexi,27Y0M@189775|Thermomicrobia 189775|Thermomicrobia G M42 glutamyl aminopeptidase - - - - - - - - - - - - Peptidase_M42 k59_750467_1 1379270.AUXF01000003_gene3647 3.4e-53 186.0 COG4585@1|root,COG4585@2|Bacteria,1ZSM2@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Histidine kinase - - - - - - - - - - - - HisKA_3 k59_1486655_1 1121033.AUCF01000004_gene4990 3.33e-32 123.0 COG0811@1|root,COG0811@2|Bacteria,1PPAP@1224|Proteobacteria,2TS0F@28211|Alphaproteobacteria,2JUNK@204441|Rhodospirillales 204441|Rhodospirillales U MotA/TolQ/ExbB proton channel family - - - - - - - - - - - - MotA_ExbB k59_1639600_1 1207063.P24_13598 1.58e-145 431.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2TTAY@28211|Alphaproteobacteria,2JQ9T@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_8894_1 1280948.HY36_16430 8.92e-22 94.7 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2U3DD@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_1639601_1 63405.XP_002849037.1 4.36e-35 131.0 28JUJ@1|root,2QS8H@2759|Eukaryota,3ADH9@33154|Opisthokonta,3Q32Z@4751|Fungi,3RK4S@4890|Ascomycota,20THT@147545|Eurotiomycetes,3B3WM@33183|Onygenales,3FSBA@34384|Arthrodermataceae 4751|Fungi S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_855378_2 469383.Cwoe_5786 1.98e-41 142.0 COG3871@1|root,COG3871@2|Bacteria,2I2QZ@201174|Actinobacteria,4CQ6F@84995|Rubrobacteria 84995|Rubrobacteria S Pfam:Pyridox_oxidase - - - - - - - - - - - - Putative_PNPOx k59_855378_3 1163617.SCD_n02328 2.45e-26 103.0 COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,2VSE7@28216|Betaproteobacteria 28216|Betaproteobacteria J chain release factor yaeJ - - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 k59_855378_4 991905.SL003B_3484 3.02e-07 51.2 COG1556@1|root,COG1556@2|Bacteria,1R4TE@1224|Proteobacteria,2U5II@28211|Alphaproteobacteria,4BQKS@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S LUD domain - - - ko:K00782 - - - - ko00000 - - - LUD_dom k59_700391_1 436308.Nmar_0506 2.07e-112 325.0 arCOG03119@1|root,arCOG03119@2157|Archaea,41T0Y@651137|Thaumarchaeota 651137|Thaumarchaeota S PFAM SNARE associated Golgi protein - - - - - - - - - - - - - k59_700391_2 436308.Nmar_0507 8.91e-20 84.7 COG1418@1|root,arCOG01860@2157|Archaea,41T2N@651137|Thaumarchaeota 651137|Thaumarchaeota S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06950 - - - - ko00000 - - - HD k59_8898_1 395493.BegalDRAFT_3140 6.01e-105 315.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,1T1GA@1236|Gammaproteobacteria,4602W@72273|Thiotrichales 72273|Thiotrichales E Cys/Met metabolism PLP-dependent enzyme - - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_958843_1 566466.NOR53_3166 6.68e-108 327.0 COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,1RW40@1236|Gammaproteobacteria,1J8F4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_1278934_1 640081.Dsui_3398 6.16e-84 259.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,2KVNH@206389|Rhodocyclales 206389|Rhodocyclales L PFAM Integrase core domain - - - - - - - - - - - - HTH_38,rve k59_1432967_1 436308.Nmar_0778 1.12e-13 67.0 COG0517@1|root,arCOG00606@2157|Archaea,41SRY@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_1432967_2 436308.Nmar_0777 2.26e-45 147.0 COG1828@1|root,arCOG04462@2157|Archaea,41STY@651137|Thaumarchaeota 651137|Thaumarchaeota F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purS - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - PurS k59_280996_1 999611.KI421504_gene342 7.31e-142 412.0 COG0075@1|root,COG0075@2|Bacteria,1R4JQ@1224|Proteobacteria,2TV9E@28211|Alphaproteobacteria,281BZ@191028|Leisingera 28211|Alphaproteobacteria E Serine-pyruvate aminotransferase archaeal aspartate aminotransferase - - - - - - - - - - - - Aminotran_5 k59_1278943_1 1528106.JRJE01000031_gene3290 4.61e-73 238.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2JPA1@204441|Rhodospirillales 204441|Rhodospirillales P COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_1432977_1 706587.Desti_1112 5.5e-71 221.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WISZ@28221|Deltaproteobacteria,2MQ9P@213462|Syntrophobacterales 28221|Deltaproteobacteria O PFAM Band 7 protein - - - - - - - - - - - - Band_7 k59_1432977_2 325452.fgenesh_scip_prom.46568.2919 1.75e-05 50.4 COG0624@1|root,KOG2275@2759|Eukaryota 2759|Eukaryota E aminoacylase activity - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1486686_1 1301098.PKB_3379 5.45e-94 296.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the ClpA ClpB family clpA GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_493105_1 414684.RC1_2771 3.09e-59 208.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria,2JPKU@204441|Rhodospirillales 204441|Rhodospirillales S Penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_387884_1 1037409.BJ6T_00390 3.5e-20 88.2 COG0834@1|root,COG0834@2|Bacteria,1P157@1224|Proteobacteria,2UVH1@28211|Alphaproteobacteria,3K4S4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - ko:K10001 ko02010,ko02020,map02010,map02020 M00230 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.19,3.A.1.3.4 - - SBP_bac_3 k59_387884_2 1123229.AUBC01000025_gene4464 5.72e-33 122.0 COG0765@1|root,COG0765@2|Bacteria,1MUVX@1224|Proteobacteria,2TRAT@28211|Alphaproteobacteria,3JVGT@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Binding-protein-dependent transport system inner membrane component gltJ - - ko:K10003 ko02010,ko02020,map02010,map02020 M00230 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.19,3.A.1.3.4 - - BPD_transp_1 k59_228267_1 357804.Ping_1825 1.95e-139 399.0 28KEA@1|root,2ZA0J@2|Bacteria,1R5TS@1224|Proteobacteria,1RR2S@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Sulfotransferase domain - - 2.8.2.1 ko:K01014 ko05204,map05204 - R01242 RC00007,RC00128 ko00000,ko00001,ko01000 - - - Sulfotransfer_1 k59_750492_1 1211114.ALIP01000003_gene2794 1.52e-74 238.0 COG4230@1|root,COG4230@2|Bacteria,1QXGP@1224|Proteobacteria,1T3C0@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Aldehyde dehydrogenase family - - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh k59_809104_1 472759.Nhal_3604 1.42e-22 93.6 COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,1S6FG@1236|Gammaproteobacteria,1WY34@135613|Chromatiales 135613|Chromatiales S pfam ammecr1 - - - ko:K09141 - - - - ko00000 - - - AMMECR1 k59_809104_2 1266914.ATUK01000010_gene1174 1.28e-08 60.1 COG1357@1|root,COG1357@2|Bacteria,1N15C@1224|Proteobacteria,1S9A9@1236|Gammaproteobacteria,1X1IB@135613|Chromatiales 135613|Chromatiales S Pentapeptide repeats (8 copies) - - - - - - - - - - - - Pentapeptide k59_77352_1 1121459.AQXE01000001_gene2494 9.09e-90 288.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2M8M4@213115|Desulfovibrionales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-2 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_758345_1 883.DvMF_0996 4.35e-51 178.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42MAI@68525|delta/epsilon subdivisions,2WJ8M@28221|Deltaproteobacteria,2M84R@213115|Desulfovibrionales 28221|Deltaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_1125031_1 1219077.VAZ01S_012_00650 1.37e-72 232.0 COG3633@1|root,COG3633@2|Bacteria,1MXE1@1224|Proteobacteria,1RP9B@1236|Gammaproteobacteria,1XSMF@135623|Vibrionales 135623|Vibrionales E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) sstT GO:0003674,GO:0005215,GO:0005310,GO:0005342,GO:0005343,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006835,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015081,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015672,GO:0015711,GO:0015849,GO:0017153,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1903825,GO:1905039 - ko:K07862 - - - - ko00000,ko02000 2.A.23.4 - - SDF k59_1329213_1 471852.Tcur_1518 2.37e-74 257.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,2GIYE@201174|Actinobacteria,4EMF2@85012|Streptosporangiales 201174|Actinobacteria EQ Hydantoinase B/oxoprolinase oplA - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - iNJ661.Rv0266c Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_1172879_1 478801.Ksed_00660 5.93e-52 179.0 COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria 201174|Actinobacteria L Transposase - - - - - - - - - - - - Transposase_mut k59_758362_1 448385.sce5974 4.26e-24 97.4 COG0412@1|root,COG0412@2|Bacteria,1PSEB@1224|Proteobacteria,4340G@68525|delta/epsilon subdivisions,2X4F0@28221|Deltaproteobacteria,2YYWA@29|Myxococcales 28221|Deltaproteobacteria Q Dienelactone hydrolase and related enzymes - - - - - - - - - - - - DLH k59_758362_2 402881.Plav_2680 4.63e-85 270.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 k59_1650853_1 330214.NIDE3384 5.29e-143 442.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,3J0SV@40117|Nitrospirae 40117|Nitrospirae C Conserved region in glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_341794_1 1349822.NSB1T_03020 7.27e-45 154.0 COG1192@1|root,COG1192@2|Bacteria,4NFEX@976|Bacteroidetes,2FMX2@200643|Bacteroidia,22W77@171551|Porphyromonadaceae 976|Bacteroidetes D Chromosome partitioning protein ParA soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_134689_1 1123269.NX02_06230 0.000625 47.4 COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,2U5B6@28211|Alphaproteobacteria,2K2WG@204457|Sphingomonadales 204457|Sphingomonadales O Glutathione S-transferase, C-terminal domain - - 5.2.1.4 ko:K01801 ko00350,ko01100,ko01120,map00350,map01100,map01120 - R03868 RC00867 ko00000,ko00001,ko01000 - - - GST_C_2,GST_N_3 k59_134689_2 211586.SO_1667 1.55e-23 94.0 COG2154@1|root,COG2154@2|Bacteria,1RH99@1224|Proteobacteria,1S5YX@1236|Gammaproteobacteria,2QBVG@267890|Shewanellaceae 1236|Gammaproteobacteria H PFAM transcriptional coactivator pterin dehydratase phhB - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a k59_1497582_1 443152.MDG893_15422 4.49e-119 348.0 COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,1RMYJ@1236|Gammaproteobacteria,469V2@72275|Alteromonadaceae 1236|Gammaproteobacteria S Amidohydrolase fldW - 4.1.1.45,4.2.1.83 ko:K03392,ko:K10220 ko00362,ko00380,ko01100,ko01120,map00362,map00380,map01100,map01120 M00038 R04323,R04478 RC00498,RC00779 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_2 k59_1172891_1 1051646.VITU9109_22441 6.45e-32 129.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1XT5X@135623|Vibrionales 135623|Vibrionales S COG0733 Na -dependent transporters of the SNF family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_708222_1 765420.OSCT_3169 1.32e-08 56.2 COG0260@1|root,COG0260@2|Bacteria,2G617@200795|Chloroflexi,37528@32061|Chloroflexia 32061|Chloroflexia E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_1233897_1 1229909.NSED_06095 2.15e-75 235.0 COG1980@1|root,arCOG04180@2157|Archaea,41S67@651137|Thaumarchaeota 651137|Thaumarchaeota G Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) fbp - 3.1.3.11,4.1.2.13 ko:K01622 ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00003 R00762,R01068,R01070,R02568,R04780 RC00017,RC00438,RC00439 ko00000,ko00001,ko00002,ko01000 - - - FBPase_3 k59_966947_1 1283299.AUKG01000001_gene1539 1.42e-19 89.7 COG0863@1|root,COG0863@2|Bacteria,2IM4X@201174|Actinobacteria 201174|Actinobacteria L DNA methylase - - - - - - - - - - - - N6_N4_Mtase k59_289620_2 1229909.NSED_02445 2.67e-100 296.0 COG0580@1|root,arCOG04431@2157|Archaea,41SJI@651137|Thaumarchaeota 651137|Thaumarchaeota G Major Intrinsic Protein - - - ko:K06188 - - - - ko00000,ko02000 1.A.8 - - MIP k59_504178_1 1479237.JMLY01000001_gene2617 3.18e-37 131.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S607@1236|Gammaproteobacteria,468FQ@72275|Alteromonadaceae 1236|Gammaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_1233905_1 765420.OSCT_2607 0.000186 49.7 COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG5002@2|Bacteria,2G8J1@200795|Chloroflexi 200795|Chloroflexi T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_341818_1 89187.ISM_13860 2.6e-95 300.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR78@28211|Alphaproteobacteria,46P5V@74030|Roseovarius 28211|Alphaproteobacteria C COG1960 Acyl-CoA dehydrogenases mcd - 1.3.8.12 ko:K14448 ko00630,ko01120,ko01200,map00630,map01120,map01200 M00373 R09293 RC02483 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_916352_1 1340810.V5USR1_9CAUD 1.04e-20 98.2 4QAWG@10239|Viruses,4QV6X@35237|dsDNA viruses no RNA stage,4QPII@28883|Caudovirales,4QI76@10662|Myoviridae 10662|Myoviridae S DNA helicase activity - - - - - - - - - - - - - k59_180632_1 1211579.PP4_20420 3.11e-59 196.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1YY3Z@136845|Pseudomonas putida group 1236|Gammaproteobacteria C PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - iJN746.PP_3747 CCG,Fer4_7,Fer4_8 k59_89451_1 690850.Desaf_2634 4.01e-39 145.0 COG1463@1|root,COG1463@2|Bacteria,1MYEF@1224|Proteobacteria,42SPY@68525|delta/epsilon subdivisions,2WP3D@28221|Deltaproteobacteria,2MG7C@213115|Desulfovibrionales 28221|Deltaproteobacteria Q PFAM Mammalian cell entry related - - - ko:K02067,ko:K06192 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_89451_2 519989.ECTPHS_05085 1.88e-23 96.3 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1S1PR@1236|Gammaproteobacteria,1WY6G@135613|Chromatiales 135613|Chromatiales Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_343145_1 709797.CSIRO_3879 3.27e-46 164.0 COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2TTC7@28211|Alphaproteobacteria,3JVFI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_864370_1 1286631.X805_29990 1.97e-80 261.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VM92@28216|Betaproteobacteria,1KJMX@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Ring hydroxylating alpha subunit (catalytic domain) - - 1.14.13.111 ko:K16968 ko00920,map00920 - R09513 RC02556 ko00000,ko00001,ko01000 - - - Rieske,Ring_hydroxyl_A k59_864370_2 631454.N177_3218 1.17e-09 58.5 COG3467@1|root,COG3467@2|Bacteria,1MWQE@1224|Proteobacteria,2TR7J@28211|Alphaproteobacteria,1JQ3S@119043|Rhodobiaceae 28211|Alphaproteobacteria S Pyridoxamine 5'-phosphate oxidase - - - ko:K07005 - - - - ko00000 - - - Pyridox_ox_2 k59_1499004_1 1121456.ATVA01000016_gene1990 2.26e-75 243.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MAV@68525|delta/epsilon subdivisions,2WJC9@28221|Deltaproteobacteria,2M8P2@213115|Desulfovibrionales 28221|Deltaproteobacteria E Belongs to the alpha-IPM synthase homocitrate synthase family cimA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1535557_1 396588.Tgr7_0636 8.38e-159 461.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1WWVW@135613|Chromatiales 135613|Chromatiales C TIGRFAM cytochrome c oxidase accessory protein - - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_1535557_2 983545.Glaag_2193 1.25e-27 108.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,464W3@72275|Alteromonadaceae 1236|Gammaproteobacteria C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - iJN746.PP_4253 Cytochrome_CBB3,FixP_N k59_709252_1 395494.Galf_2319 2.77e-27 116.0 2DNAT@1|root,32WH7@2|Bacteria,1N2AT@1224|Proteobacteria,2VV51@28216|Betaproteobacteria,44W1G@713636|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_89463_1 555779.Dthio_PD2648 1.33e-133 387.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WMES@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_290958_1 762376.AXYL_05508 4.06e-92 288.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2W02G@28216|Betaproteobacteria,3T60A@506|Alcaligenaceae 28216|Betaproteobacteria EH Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_290958_2 1469245.JFBG01000055_gene2489 5.32e-23 96.7 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1WWVA@135613|Chromatiales 135613|Chromatiales I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_448873_1 436308.Nmar_1766 2.63e-71 233.0 arCOG02362@1|root,arCOG07810@1|root,arCOG02362@2157|Archaea,arCOG07810@2157|Archaea,41T0S@651137|Thaumarchaeota 651137|Thaumarchaeota N Adenylate guanylate cyclase with integral membrane sensor - - - - - - - - - - - - Guanylate_cyc,HAMP k59_1173829_1 436308.Nmar_0047 2.59e-91 281.0 COG1819@1|root,arCOG01393@2157|Archaea,41SZK@651137|Thaumarchaeota 651137|Thaumarchaeota G Glycosyl transferase family 1 - - - - - - - - - - - - - k59_1291519_1 1229909.NSED_09675 2.16e-105 316.0 COG1252@1|root,arCOG01067@2157|Archaea 2157|Archaea C COG1252 NADH dehydrogenase, FAD-containing subunit ndh2 - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1074436_1 78245.Xaut_4005 1.01e-24 101.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,3F1JR@335928|Xanthobacteraceae 28211|Alphaproteobacteria L PFAM Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_136039_1 290400.Jann_4117 5.62e-47 162.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria 1224|Proteobacteria S succinylglutamate desuccinylase aspartoacylase - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_709273_1 1469245.JFBG01000023_gene1243 2.44e-89 289.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales 135613|Chromatiales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_664537_1 391625.PPSIR1_32929 4.82e-12 66.2 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42U04@68525|delta/epsilon subdivisions,2WQA9@28221|Deltaproteobacteria,2YWN4@29|Myxococcales 28221|Deltaproteobacteria K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_664537_2 1028805.GGC_0287 3.79e-27 105.0 COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,1Y7QN@135625|Pasteurellales 135625|Pasteurellales H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC k59_505611_1 1380350.JIAP01000012_gene423 3.07e-38 150.0 COG1409@1|root,COG2931@1|root,COG3204@1|root,COG1409@2|Bacteria,COG2931@2|Bacteria,COG3204@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,43I5T@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - 3.4.24.40 ko:K01406,ko:K07004 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - An_peroxidase,Cadherin,Calx-beta,Exo_endo_phos,HemolysinCabind,Metallophos,Peptidase_M10_C k59_1535583_1 2340.JV46_13030 2.7e-93 281.0 COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,1S7ID@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_1535583_2 2340.JV46_13040 8.57e-36 133.0 COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J85H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N,Transketolase_C k59_1535585_1 1385935.N836_00115 1.69e-33 129.0 COG3039@1|root,COG3039@2|Bacteria,1G3IA@1117|Cyanobacteria,1HEFE@1150|Oscillatoriales 1117|Cyanobacteria L Transposase domain (DUF772) - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_664544_1 349163.Acry_2179 8.65e-34 125.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria,2JR9I@204441|Rhodospirillales 204441|Rhodospirillales KT COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_664544_2 1049564.TevJSym_ap00180 2.14e-16 82.0 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,1RPDY@1236|Gammaproteobacteria,1J6T8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain cpxA GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007155,GO:0007165,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0022610,GO:0023014,GO:0023052,GO:0031224,GO:0031589,GO:0035556,GO:0036211,GO:0042710,GO:0042802,GO:0043170,GO:0043412,GO:0043708,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044464,GO:0044764,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0090605,GO:0140096,GO:1901564 2.7.13.3 ko:K07640 ko01503,ko02020,map01503,map02020 M00447,M00727,M00728 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - CpxA_peri,HAMP,HATPase_c,HisKA k59_550164_1 1278309.KB907106_gene1275 3.49e-111 330.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1XHZA@135619|Oceanospirillales 135619|Oceanospirillales K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_967952_1 435908.IDSA_04270 1.94e-79 261.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,2QFNI@267893|Idiomarinaceae 1236|Gammaproteobacteria O Belongs to the ClpA ClpB family clpA GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_395612_1 1123242.JH636434_gene5235 1.87e-29 125.0 COG0457@1|root,COG3119@1|root,COG0457@2|Bacteria,COG3119@2|Bacteria,2J3IX@203682|Planctomycetes 203682|Planctomycetes P arylsulfatase A - - - - - - - - - - - - Sulfatase,TPR_16,TPR_19,TPR_2 k59_917911_1 1121104.AQXH01000002_gene653 1.47e-174 492.0 COG0174@1|root,COG0174@2|Bacteria,4NGG2@976|Bacteroidetes,1IQ8U@117747|Sphingobacteriia 976|Bacteroidetes E PFAM glutamine synthetase catalytic region glnII - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_917911_2 1266925.JHVX01000003_gene584 4.23e-80 252.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,371R9@32003|Nitrosomonadales 28216|Betaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_343223_1 330214.NIDE2050 3.87e-34 127.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - TraF_2 k59_759375_1 1294143.H681_06935 8.65e-36 127.0 2DMP1@1|root,32SS8@2|Bacteria,1NC27@1224|Proteobacteria,1SBA3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3237) - - - - - - - - - - - - DUF3237 k59_917939_1 754476.Q7A_1381 1.91e-13 72.0 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,4614Z@72273|Thiotrichales 72273|Thiotrichales L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_1020609_1 330214.NIDE1728 2.86e-150 440.0 COG0443@1|root,COG0443@2|Bacteria,3J0D2@40117|Nitrospirae 40117|Nitrospirae O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_917949_1 314285.KT71_02962 1.94e-78 254.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,1J5DB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_1182461_1 1229909.NSED_04815 3.49e-23 93.6 COG0745@1|root,arCOG02595@2157|Archaea,41T9R@651137|Thaumarchaeota 651137|Thaumarchaeota T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_354181_1 1219049.SP5_034_00540 4.93e-08 60.1 COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K01C@204457|Sphingomonadales 204457|Sphingomonadales T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_1245456_1 1046724.KB889878_gene1564 1.03e-24 100.0 COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,1RMKF@1236|Gammaproteobacteria,465AA@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the peptidase S33 family pip - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_459434_1 1499684.CCNP01000026_gene3792 1.06e-33 125.0 COG2197@1|root,COG2197@2|Bacteria,1VB97@1239|Firmicutes,24IHJ@186801|Clostridia,36RM8@31979|Clostridiaceae 186801|Clostridia T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_977405_1 1168065.DOK_14199 4.8e-65 211.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1J4WE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain degS GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564 - ko:K04691,ko:K04772 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Trypsin_2 k59_977405_2 323848.Nmul_A0818 1.2e-74 237.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VHX2@28216|Betaproteobacteria,371PJ@32003|Nitrosomonadales 28216|Betaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_189451_1 436308.Nmar_0681 2.19e-59 198.0 COG0457@1|root,arCOG03032@2157|Archaea,41SBD@651137|Thaumarchaeota 651137|Thaumarchaeota S TPR repeat - - - - - - - - - - - - TPR_1,TPR_2,TPR_8 k59_1245464_1 1121104.AQXH01000001_gene1307 3.02e-43 164.0 COG1361@1|root,COG2304@1|root,COG2931@1|root,COG3420@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2304@2|Bacteria,COG2931@2|Bacteria,COG3420@2|Bacteria,COG4932@2|Bacteria,4NMB8@976|Bacteroidetes,1IQMS@117747|Sphingobacteriia 976|Bacteroidetes M Domain of unknown function DUF11 - - - - - - - - - - - - CHU_C,Calx-beta,DUF11,HYR,SdrD_B k59_247121_1 1267535.KB906767_gene4838 3.66e-31 125.0 COG0457@1|root,COG3119@1|root,COG0457@2|Bacteria,COG3119@2|Bacteria 2|Bacteria P arylsulfatase activity - - - - - - - - - - - - Sulfatase,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_768610_1 1144275.COCOR_06731 1.3e-44 159.0 COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 k59_719170_1 1141136.K4F9K9_9CAUD 5.57e-67 225.0 4QBAK@10239|Viruses,4QY34@35237|dsDNA viruses no RNA stage,4QQBQ@28883|Caudovirales,4QIQI@10662|Myoviridae 10662|Myoviridae S Bacteriophage T4-like capsid assembly protein (Gp20) - GO:0005575,GO:0019012 - - - - - - - - - - - k59_1085668_1 525904.Tter_2623 3.06e-69 231.0 COG1060@1|root,COG1060@2|Bacteria,2NP8W@2323|unclassified Bacteria 2|Bacteria H Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) fbiC - 1.21.98.1,2.5.1.77 ko:K11779,ko:K11784 ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120 M00378 R08588,R09396 RC01381,RC02329,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - CofC,Radical_SAM k59_873698_1 1454004.AW11_02007 1.23e-72 243.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KQ5Y@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria V MMPL family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1137695_1 1304885.AUEY01000019_gene1169 1.41e-30 122.0 COG1075@1|root,COG1075@2|Bacteria,1NYAK@1224|Proteobacteria,42Q3C@68525|delta/epsilon subdivisions,2WMAK@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_6 k59_1666119_2 448385.sce6494 5.21e-30 112.0 COG0454@1|root,COG0456@2|Bacteria,1RJ1K@1224|Proteobacteria,431S0@68525|delta/epsilon subdivisions 1224|Proteobacteria K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 k59_768628_2 643648.Slip_1237 8.88e-75 246.0 COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1UDNN@1239|Firmicutes,24DF4@186801|Clostridia 186801|Clostridia I 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal - - 2.3.3.10 ko:K01641 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130 M00088,M00095 R01978 RC00004,RC00503 ko00000,ko00001,ko00002,ko01000 - - - ACP_syn_III_C,DUF35_N,OB_aCoA_assoc k59_678300_1 1168059.KB899087_gene4272 5.44e-26 110.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2TTE8@28211|Alphaproteobacteria,3EYBU@335928|Xanthobacteraceae 28211|Alphaproteobacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_678301_1 519989.ECTPHS_12793 4.09e-99 295.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria,1WW81@135613|Chromatiales 135613|Chromatiales E TIGRFAM Serine O-acetyltransferase - - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_1666129_1 1089544.KB912942_gene3834 8.51e-12 68.2 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4EAQU@85010|Pseudonocardiales 201174|Actinobacteria C CoA-transferase family III - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_1666129_2 999541.bgla_2g01900 1.03e-17 85.5 COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,2VHID@28216|Betaproteobacteria,1K16P@119060|Burkholderiaceae 28216|Betaproteobacteria L SMART DNA-directed DNA polymerase B polB - 2.7.7.7 ko:K02336 - - - - ko00000,ko01000,ko03400 - - - DNA_pol_B,DNA_pol_B_exo1 k59_354235_1 1121440.AUMA01000002_gene2265 1.74e-86 280.0 COG2172@1|root,COG2208@1|root,COG2770@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,COG2770@2|Bacteria,1MXJQ@1224|Proteobacteria,42MFQ@68525|delta/epsilon subdivisions,2WIJ4@28221|Deltaproteobacteria,2M7Z5@213115|Desulfovibrionales 28221|Deltaproteobacteria KT SMART protein phosphatase 2C domain protein - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - Cache_3-Cache_2,HAMP,SpoIIE,dCache_1,dCache_2 k59_519385_2 754477.Q7C_1743 3.01e-48 155.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,460WX@72273|Thiotrichales 72273|Thiotrichales O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_1182533_2 1168067.JAGP01000001_gene1243 1.4e-08 54.3 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,1RQ0Y@1236|Gammaproteobacteria,460SM@72273|Thiotrichales 72273|Thiotrichales Q MlaD protein mlaD - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_929212_1 1220535.IMCC14465_11440 1.77e-49 179.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1666166_1 251221.35212624 6.45e-26 105.0 COG3961@1|root,COG3961@2|Bacteria,1G1A5@1117|Cyanobacteria 1117|Cyanobacteria C Belongs to the TPP enzyme family pdc - 4.1.1.74 ko:K04103 ko00380,ko01100,map00380,map01100 - R01974 RC00506 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1666172_1 96561.Dole_1813 1e-56 187.0 COG1373@1|root,COG1373@2|Bacteria,1NQGE@1224|Proteobacteria,42R19@68525|delta/epsilon subdivisions,2WMNW@28221|Deltaproteobacteria,2MMR8@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF4143) - - - - - - - - - - - - AAA_14,DUF4143 k59_873751_1 1239962.C943_01254 2.59e-10 63.2 COG2085@1|root,COG2085@2|Bacteria,4NEC7@976|Bacteroidetes,47QJ7@768503|Cytophagia 976|Bacteroidetes S Rossmann-like domain - - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored k59_404686_1 1118054.CAGW01000050_gene1200 8.82e-11 67.4 COG1612@1|root,COG1612@2|Bacteria,1TR4W@1239|Firmicutes,4HC12@91061|Bacilli,26QIV@186822|Paenibacillaceae 91061|Bacilli O cytochrome oxidase assembly ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_247192_1 1123261.AXDW01000007_gene2174 7.1e-62 207.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1X4ZI@135614|Xanthomonadales 135614|Xanthomonadales U AAA domain - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_835518_1 1123320.KB889585_gene1873 2.86e-51 174.0 COG1960@1|root,COG1960@2|Bacteria,2GK9C@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase fadE27 - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_247201_1 1123367.C666_07745 5.22e-08 60.5 COG3083@1|root,COG3083@2|Bacteria,1MX6X@1224|Proteobacteria,2VJH1@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF3413) - - - ko:K07014 - - - - ko00000 - - - DUF3413,Sulfatase k59_404699_1 1415779.JOMH01000001_gene1099 2.08e-44 156.0 COG3327@1|root,COG3327@2|Bacteria,1RABS@1224|Proteobacteria,1S2WE@1236|Gammaproteobacteria,1X6K8@135614|Xanthomonadales 135614|Xanthomonadales K PaaX-like protein C-terminal domain - - - - - - - - - - - - PaaX,PaaX_C k59_1085744_1 436308.Nmar_1399 2.66e-39 148.0 arCOG08705@1|root,arCOG08705@2157|Archaea,41SXV@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_247203_1 1167006.UWK_02800 7.3e-75 239.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2MHKJ@213118|Desulfobacterales 28221|Deltaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_929241_2 1118054.CAGW01000053_gene1477 1.33e-56 190.0 COG3191@1|root,COG3191@2|Bacteria,1TP60@1239|Firmicutes,4HD7F@91061|Bacilli,26V5I@186822|Paenibacillaceae 91061|Bacilli EQ Peptidase family S58 - - - - - - - - - - - - Peptidase_S58 k59_1603189_1 1121904.ARBP01000006_gene3897 4.11e-64 211.0 COG1012@1|root,COG1012@2|Bacteria,4NFPJ@976|Bacteroidetes,47JJR@768503|Cytophagia 976|Bacteroidetes C Belongs to the aldehyde dehydrogenase family pcd - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_247206_1 105559.Nwat_3083 4.32e-92 278.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1WWNM@135613|Chromatiales 135613|Chromatiales H Belongs to the FPP GGPP synthase family - - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_1452743_1 65497.JODV01000002_gene4216 0.000211 43.5 COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4DYRU@85010|Pseudonocardiales 201174|Actinobacteria L Belongs to the 'phage' integrase family. XerC subfamily xerC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_1452743_2 1192034.CAP_1146 2.99e-64 214.0 COG1206@1|root,COG1206@2|Bacteria,1MWNQ@1224|Proteobacteria,42MTS@68525|delta/epsilon subdivisions,2WJ50@28221|Deltaproteobacteria,2YU50@29|Myxococcales 28221|Deltaproteobacteria J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs trmFO GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 ko:K04094 - - - - ko00000,ko01000,ko03016,ko03036 - - - GIDA k59_519469_1 646529.Desaci_1193 1.8e-05 49.3 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia 186801|Clostridia KT Sigma-54 interaction domain - - - ko:K02688,ko:K03721,ko:K06714 - - - - ko00000,ko03000 - - - CBS,HTH_8,PAS,PAS_4,PAS_8,PAS_9,PrpR_N,Sigma54_activat k59_835543_1 983545.Glaag_0204 4.51e-56 186.0 COG2962@1|root,COG2962@2|Bacteria,1MX5G@1224|Proteobacteria,1RMAC@1236|Gammaproteobacteria,465R2@72275|Alteromonadaceae 1236|Gammaproteobacteria S RarD protein rarD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944 - ko:K05786 - - - - ko00000,ko02000 2.A.7.7 - - EamA k59_835543_2 1126627.BAWE01000004_gene2550 2.1e-20 89.7 COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,2TSSE@28211|Alphaproteobacteria,3JR24@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Malonyl-CoA decarboxylase MA20_01120 - 4.1.1.9 ko:K01578 ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152 - R00233 RC00040 ko00000,ko00001,ko01000 - - - MCD,MCD_N k59_1666219_1 702113.PP1Y_AT23513 6.23e-84 273.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR38@28211|Alphaproteobacteria,2K3HH@204457|Sphingomonadales 204457|Sphingomonadales G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1338770_1 330214.NIDE3216 5.92e-68 229.0 COG0178@1|root,COG0178@2|Bacteria,3J0ZV@40117|Nitrospirae 40117|Nitrospirae L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - - k59_560194_1 580332.Slit_1215 5.01e-55 175.0 28PZA@1|root,2ZCIS@2|Bacteria,1RCMD@1224|Proteobacteria,2VYEF@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1544497_2 1229909.NSED_09685 1.76e-25 98.6 COG0071@1|root,arCOG01833@2157|Archaea,41SPJ@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_611678_1 864051.BurJ1DRAFT_1560 1.01e-37 144.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,1KJBY@119065|unclassified Burkholderiales 28216|Betaproteobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PEGA,Pkinase k59_611678_2 357808.RoseRS_1462 3.83e-08 56.6 COG1716@1|root,COG1716@2|Bacteria,2G9CS@200795|Chloroflexi,375YC@32061|Chloroflexia 32061|Chloroflexia T PFAM Forkhead-associated protein - - - - - - - - - - - - FHA k59_1666238_2 59538.XP_005977953.1 8.92e-19 89.4 COG1028@1|root,KOG1208@2759|Eukaryota,38CZD@33154|Opisthokonta,3BACQ@33208|Metazoa,3CSEJ@33213|Bilateria,4883Z@7711|Chordata,4917U@7742|Vertebrata,3J8YR@40674|Mammalia 33208|Metazoa Q response to high light intensity RDH13 GO:0001523,GO:0001654,GO:0001754,GO:0003407,GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006066,GO:0006629,GO:0006720,GO:0006721,GO:0007275,GO:0007399,GO:0007423,GO:0008106,GO:0008150,GO:0008152,GO:0009314,GO:0009416,GO:0009628,GO:0009642,GO:0009644,GO:0009653,GO:0009887,GO:0009987,GO:0010817,GO:0010842,GO:0016020,GO:0016101,GO:0016491,GO:0016614,GO:0016616,GO:0019866,GO:0022008,GO:0030154,GO:0030182,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0034308,GO:0034754,GO:0042445,GO:0042461,GO:0042462,GO:0042572,GO:0043010,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046530,GO:0048468,GO:0048513,GO:0048592,GO:0048593,GO:0048646,GO:0048666,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050896,GO:0052650,GO:0055114,GO:0060041,GO:0060042,GO:0065007,GO:0065008,GO:0071704,GO:0090596,GO:1901615 1.1.1.300 ko:K11161 - - - - ko00000,ko01000 - - - adh_short k59_835568_1 697282.Mettu_2494 0.000113 44.3 COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,1XDKQ@135618|Methylococcales 135618|Methylococcales G pfkB family carbohydrate kinase - - 2.7.1.20 ko:K00856 ko00230,ko01100,map00230,map01100 - R00185 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_835568_3 1133850.SHJG_0868 2.6e-14 72.4 COG3193@1|root,COG3193@2|Bacteria,2IHWI@201174|Actinobacteria 201174|Actinobacteria S protein possibly involved in utilization of glycolate and propanediol - - - - - - - - - - - - Haem_degrading k59_146381_1 330214.NIDE0002 2.08e-89 272.0 COG0592@1|root,COG0592@2|Bacteria,3J0RU@40117|Nitrospirae 40117|Nitrospirae L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_1512840_1 1304874.JAFY01000002_gene684 8.42e-96 294.0 COG0031@1|root,COG0031@2|Bacteria,3TA7I@508458|Synergistetes 508458|Synergistetes E PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit - - 2.3.1.263 ko:K21400 - - - - ko00000,ko01000 - - - PALP k59_1512840_2 555079.Toce_1488 8.29e-09 53.5 2E6IF@1|root,3315M@2|Bacteria,1VAX0@1239|Firmicutes,24N55@186801|Clostridia,42HBK@68295|Thermoanaerobacterales 186801|Clostridia - - ortA GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 2.3.1.263 ko:K21399 - - - - ko00000,ko01000 - - - - k59_18238_1 330214.NIDE1532 8.2e-27 106.0 COG1539@1|root,COG2520@1|root,COG1539@2|Bacteria,COG2520@2|Bacteria 2|Bacteria J tRNA (guanine(37)-N(1))-methyltransferase activity folB - 1.13.11.81,2.1.1.228,3.1.3.18,4.1.2.25,5.1.99.8 ko:K01091,ko:K01633,ko:K15429 ko00630,ko00790,ko01100,ko01110,ko01130,map00630,map00790,map01100,map01110,map01130 M00126,M00840 R00597,R01334,R03504,R11037,R11073 RC00003,RC00017,RC00334,RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000,ko03016 - - - FolB,rRNA_methylase k59_18238_2 1121438.JNJA01000002_gene3517 2.63e-24 101.0 COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,42N9R@68525|delta/epsilon subdivisions,2WN5P@28221|Deltaproteobacteria,2M85C@213115|Desulfovibrionales 28221|Deltaproteobacteria S SMART phosphoesterase PHP domain protein - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_1305431_1 268746.Q58MM6_BPPRM 1.72e-46 163.0 4QHDM@10239|Viruses,4QYV6@35237|dsDNA viruses no RNA stage,4QRD0@28883|Caudovirales,4QI2W@10662|Myoviridae 10662|Myoviridae S Terminase-like family - GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016032,GO:0016043,GO:0016787,GO:0016788,GO:0019058,GO:0019068,GO:0019069,GO:0019072,GO:0019075,GO:0022607,GO:0032991,GO:0034641,GO:0043170,GO:0043493,GO:0044085,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0046483,GO:0046797,GO:0051704,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0098009,GO:1901360,GO:1902494,GO:1904949 - - - - - - - - - - - k59_1085783_1 2325.TKV_c11350 4.4e-28 115.0 COG0784@1|root,COG2199@1|root,COG3290@1|root,COG0784@2|Bacteria,COG3290@2|Bacteria,COG3706@2|Bacteria,1VADD@1239|Firmicutes,25E7Q@186801|Clostridia,42J5P@68295|Thermoanaerobacterales 186801|Clostridia T TIGRFAM Diguanylate cyclase - - 2.7.7.65 ko:K21022 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - GAF,GAF_2,GAF_3,GGDEF k59_873815_1 472175.EL18_00667 5.74e-97 308.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,43HW8@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily gsiA3 - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_100934_1 948106.AWZT01000005_gene4338 3.53e-14 68.2 COG0236@1|root,COG0236@2|Bacteria,1N7Q1@1224|Proteobacteria,2VVRR@28216|Betaproteobacteria,1K9MR@119060|Burkholderiaceae 28216|Betaproteobacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpM - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_100934_2 1236501.BAJU01000002_gene454 6.98e-13 65.9 COG0236@1|root,COG0236@2|Bacteria 2|Bacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpC - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_930328_1 1117647.M5M_19330 7.26e-31 115.0 COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,1RR3K@1236|Gammaproteobacteria,1J5HN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG2111 Multisubunit Na H antiporter, MnhB subunit - - - ko:K05566 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040,MnhB k59_930328_2 225849.swp_0939 3.91e-26 100.0 COG1320@1|root,COG1320@2|Bacteria,1QB60@1224|Proteobacteria,1T6PT@1236|Gammaproteobacteria,2QC73@267890|Shewanellaceae 1236|Gammaproteobacteria P TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit - - - ko:K05571 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - PhaG_MnhG_YufB k59_612785_1 1170562.Cal6303_2768 4.47e-09 54.7 COG0399@1|root,COG0399@2|Bacteria,1GDTU@1117|Cyanobacteria,1HSKF@1161|Nostocales 1117|Cyanobacteria J 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_612785_2 1226322.HMPREF1545_00363 6.55e-13 68.9 COG0778@1|root,COG0778@2|Bacteria,1UX3W@1239|Firmicutes,25M9B@186801|Clostridia,2N8TD@216572|Oscillospiraceae 186801|Clostridia C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_720257_1 1042375.AFPL01000016_gene16 2.95e-52 169.0 COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,1T06D@1236|Gammaproteobacteria,46D0B@72275|Alteromonadaceae 1236|Gammaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_355324_1 205922.Pfl01_4014 3.64e-28 108.0 COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,1YP2J@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria E GDSL-like Lipase/Acylhydrolase family tesA GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365 Lipase_GDSL_2 k59_355324_2 1380393.JHVP01000006_gene4059 8.01e-12 62.0 COG2343@1|root,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria,4EVRH@85013|Frankiales 201174|Actinobacteria S Domain of unknown function (DUF427) - - - - - - - - - - - - NTP_transf_9 k59_569460_2 246196.MSMEI_4080 2.99e-51 174.0 COG1249@1|root,COG1249@2|Bacteria,2GJJK@201174|Actinobacteria,23356@1762|Mycobacteriaceae 201174|Actinobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family lpd_1 - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_1611095_3 1123514.KB905899_gene1880 4.34e-26 102.0 COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,1S8F8@1236|Gammaproteobacteria,4638B@72273|Thiotrichales 72273|Thiotrichales S Urate oxidase N-terminal - - - - - - - - - - - - Urate_ox_N k59_1193255_1 378806.STAUR_4870 2.64e-58 191.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42N06@68525|delta/epsilon subdivisions,2WK5N@28221|Deltaproteobacteria,2YTX4@29|Myxococcales 28221|Deltaproteobacteria C Transketolase, pyrimidine binding domain bkdB - 1.2.4.1,1.2.4.4 ko:K00162,ko:K00167 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_364605_1 118168.MC7420_5030 1.44e-32 129.0 COG0643@1|root,COG0643@2|Bacteria,1G26V@1117|Cyanobacteria,1H78U@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_364605_2 1123252.ATZF01000001_gene1149 1.18e-19 87.0 COG2346@1|root,COG2346@2|Bacteria,1V930@1239|Firmicutes,4HJED@91061|Bacilli,27CC1@186824|Thermoactinomycetaceae 91061|Bacilli C Bacterial-like globin - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_623208_1 760117.JN27_05945 2.71e-31 118.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VH51@28216|Betaproteobacteria,472AF@75682|Oxalobacteraceae 28216|Betaproteobacteria O Peptidase family U32 yhbU - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_623208_2 314278.NB231_09093 4.99e-45 153.0 COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,1S37E@1236|Gammaproteobacteria,1WWWB@135613|Chromatiales 135613|Chromatiales O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA k59_201156_1 1469245.JFBG01000077_gene315 6.31e-53 181.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpdG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - iE2348C_1286.E2348C_4372,iJN746.PP_4187 Pyr_redox_2,Pyr_redox_dim k59_1404791_1 1379698.RBG1_1C00001G1154 4.65e-26 99.4 COG1550@1|root,COG1550@2|Bacteria,2NPYX@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF503) ylxP - - ko:K09764 - - - - ko00000 - - - DUF503 k59_1404791_2 316067.Geob_2692 1.08e-30 120.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,43UH5@69541|Desulfuromonadales 28221|Deltaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_1349471_1 335283.Neut_1507 3.91e-16 79.0 COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,2VPI8@28216|Betaproteobacteria,372CD@32003|Nitrosomonadales 28216|Betaproteobacteria I PFAM Prenyltransferase squalene oxidase shc - 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 - R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 - - - SQHop_cyclase_C,SQHop_cyclase_N k59_364616_2 519989.ECTPHS_06992 2.15e-43 156.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1WVW8@135613|Chromatiales 135613|Chromatiales EF Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_569470_1 351348.Maqu_0062 1.83e-38 139.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,465CG@72275|Alteromonadaceae 1236|Gammaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_623227_1 472759.Nhal_3802 6.08e-69 231.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1WXCY@135613|Chromatiales 135613|Chromatiales G phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_883006_1 264462.Bd1390 4.84e-05 45.8 COG0644@1|root,COG0644@2|Bacteria,1R41S@1224|Proteobacteria 1224|Proteobacteria C Tryptophan halogenase - - 1.14.19.9 ko:K14266 ko00404,ko01130,map00404,map01130 M00789,M00790 R09570 RC00949 ko00000,ko00001,ko00002,ko01000 - - - Trp_halogenase k59_883006_4 1123008.KB905697_gene3236 9.82e-09 59.3 COG3210@1|root,COG3210@2|Bacteria,4PPCP@976|Bacteroidetes 976|Bacteroidetes U Chaperone of endosialidase - - - - - - - - - - - - Peptidase_S74 k59_1555646_1 765910.MARPU_03170 1.51e-23 104.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1WXQJ@135613|Chromatiales 135613|Chromatiales S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971 k59_569478_1 1229909.NSED_09065 8.41e-42 144.0 arCOG03788@1|root,arCOG03788@2157|Archaea,41T96@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1039408_1 649638.Trad_0737 8.81e-29 120.0 COG3307@1|root,COG3307@2|Bacteria,1WNB1@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_256484_1 1173024.KI912153_gene216 8.54e-54 188.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1G2E2@1117|Cyanobacteria,1JKG2@1189|Stigonemataceae 1117|Cyanobacteria C Domain of unknown function - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_156556_1 485913.Krac_10415 2.26e-65 211.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_5,DDE_Tnp_1 k59_1349493_1 43354.JOIJ01000006_gene1838 5.92e-85 259.0 COG1024@1|root,COG1024@2|Bacteria,2HEIS@201174|Actinobacteria,4DZPT@85010|Pseudonocardiales 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_312944_1 566466.NOR53_2263 1.28e-69 220.0 COG4221@1|root,COG4221@2|Bacteria,1R83E@1224|Proteobacteria,1T1UP@1236|Gammaproteobacteria,1JABR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S KR domain - - - - - - - - - - - - adh_short k59_986894_1 194439.CT1279 1.3e-25 108.0 COG1331@1|root,COG1331@2|Bacteria,1FDQN@1090|Chlorobi 1090|Chlorobi O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_777611_1 1283300.ATXB01000001_gene43 7.54e-31 121.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XEHC@135618|Methylococcales 135618|Methylococcales P haloacid dehalogenase-like hydrolase - - - - - - - - - - - - E1-E2_ATPase,Hydrolase k59_1349505_1 477184.KYC_13733 2.76e-55 175.0 COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2VR2M@28216|Betaproteobacteria,3T7G4@506|Alcaligenaceae 28216|Betaproteobacteria C Required for insertion of 4Fe-4S clusters erpA - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_1404839_2 188626.HMPREF0321_1857 5.93e-05 50.4 COG0299@1|root,COG0299@2|Bacteria,2H8QB@201174|Actinobacteria,1ZVZB@145357|Dermacoccaceae 201174|Actinobacteria F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_416114_1 237368.SCABRO_03989 5.02e-64 210.0 COG0686@1|root,COG0686@2|Bacteria 2|Bacteria E alanine dehydrogenase activity sdh - 1.5.1.7,1.5.1.8,1.5.1.9 ko:K00290,ko:K14157 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715,R00716,R02313 RC00215,RC00217,RC00225,RC01532 ko00000,ko00001,ko00002,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_1611133_1 1408322.JHYK01000012_gene670 7.1e-15 76.6 COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,24BJ8@186801|Clostridia,27IRK@186928|unclassified Lachnospiraceae 186801|Clostridia KLT Protein tyrosine kinase - - - - - - - - - - - - FHA,PASTA,PDZ_2,Pkinase,YARHG k59_1193317_1 349124.Hhal_0964 1.03e-16 83.6 COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,1S64Q@1236|Gammaproteobacteria,1WWVF@135613|Chromatiales 135613|Chromatiales S Competence protein - - - - - - - - - - - - Pribosyltran k59_1193317_2 234621.RER_60190 2.61e-27 110.0 COG1902@1|root,COG1902@2|Bacteria,2IBTU@201174|Actinobacteria,4FYV1@85025|Nocardiaceae 201174|Actinobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - 1.8.1.20 ko:K22347 - - - - ko00000,ko01000 - - - Oxidored_FMN k59_364681_1 686578.AFFX01000005_gene4281 2.82e-59 191.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN746.PP_4715 TIM k59_364681_2 1283300.ATXB01000002_gene2929 1.42e-16 74.3 COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,1SD3P@1236|Gammaproteobacteria,1XFHV@135618|Methylococcales 135618|Methylococcales U Preprotein translocase SecG subunit - - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_1039453_2 676032.FN3523_1071 1.46e-07 53.9 COG1876@1|root,COG1876@2|Bacteria,1N1CQ@1224|Proteobacteria,1SASN@1236|Gammaproteobacteria,462IN@72273|Thiotrichales 72273|Thiotrichales E D-alanyl-D-alanine carboxypeptidase - - 3.4.17.14 ko:K07260 ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020 M00651 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 - - - VanY k59_1096506_1 500633.CLOHIR_02084 3.46e-05 44.7 arCOG05874@1|root,2ZJ01@2|Bacteria,1V450@1239|Firmicutes,24NM6@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_1096506_2 3880.AES84212 1.91e-20 90.5 2E30T@1|root,2SA69@2759|Eukaryota,37XUE@33090|Viridiplantae,3GMF3@35493|Streptophyta,4JVFX@91835|fabids 35493|Streptophyta S Cell wall-associated hydrolase - - - - - - - - - - - - - k59_1404891_1 35754.JNYJ01000009_gene1954 2.07e-30 121.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4D92K@85008|Micromonosporales 201174|Actinobacteria Q cytochrome P450 - - - - - - - - - - - - p450 k59_416184_1 1195246.AGRI_14750 4.52e-64 213.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,4663F@72275|Alteromonadaceae 1236|Gammaproteobacteria S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034203,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576 - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - iECO103_1326.ECO103_1114 MVIN k59_313019_1 268746.Q58MM7_BPPRM 9.35e-07 48.5 4QGAW@10239|Viruses,4QVUM@35237|dsDNA viruses no RNA stage,4QPP0@28883|Caudovirales,4QHVB@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_313019_2 268746.Q58MM2_BPPRM 1.53e-12 62.8 4QFE1@10239|Viruses,4QVB0@35237|dsDNA viruses no RNA stage,4QT55@28883|Caudovirales,4QK8A@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_883074_1 1278307.KB907045_gene1131 2.3e-52 177.0 COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RM84@1236|Gammaproteobacteria,2QHDQ@267894|Psychromonadaceae 1236|Gammaproteobacteria C Radical SAM superfamily epmB GO:0003674,GO:0003824,GO:0005488,GO:0016853,GO:0016866,GO:0016869,GO:0048037,GO:0051536,GO:0051539,GO:0051540 5.4.3.2 ko:K01843,ko:K19810 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000,ko03012 - - iECH74115_1262.ECH74115_5662,iECIAI39_1322.ECIAI39_4611,iS_1188.S4569 Fer4_12,Fer4_14,Radical_SAM k59_883074_2 42565.FP66_11960 2.08e-24 95.9 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,1XI52@135619|Oceanospirillales 135619|Oceanospirillales J Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_623356_1 1408445.JHXP01000007_gene385 1.05e-14 78.2 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1JCNE@118969|Legionellales 118969|Legionellales M Transglycosylase SLT domain mltB_2 - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_1404937_1 1229172.JQFA01000004_gene430 2.2e-35 128.0 COG1515@1|root,COG1515@2|Bacteria,1G2HF@1117|Cyanobacteria,1H8TY@1150|Oscillatoriales 1117|Cyanobacteria L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA nfi - 3.1.21.7 ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 k59_1349619_1 436308.Nmar_0641 2.65e-87 265.0 arCOG08669@1|root,arCOG08669@2157|Archaea,41SEB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_201332_2 330214.NIDE2778 9e-33 123.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM k59_23533_1 629265.PMA4326_00895 8.8e-17 83.2 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1RN7K@1236|Gammaproteobacteria,1Z8BD@136849|Pseudomonas syringae group 1236|Gammaproteobacteria K AraC family transcriptional regulator - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_1040949_1 1502851.FG93_05885 1.41e-33 131.0 COG1858@1|root,COG1858@2|Bacteria,1N4E1@1224|Proteobacteria,2TRXQ@28211|Alphaproteobacteria,3K6DG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_1040949_2 999547.KI421500_gene3494 0.000932 43.1 COG3221@1|root,COG3221@2|Bacteria,1MY1D@1224|Proteobacteria,2V91J@28211|Alphaproteobacteria,281ZE@191028|Leisingera 28211|Alphaproteobacteria P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - - - - - - - - - - Phosphonate-bd k59_1351732_1 105559.Nwat_0785 8.62e-99 296.0 COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria,1WXKU@135613|Chromatiales 135613|Chromatiales S PFAM Radical SAM - - - - - - - - - - - - DUF3641,Fer4_12,Radical_SAM k59_779229_1 485915.Dret_1167 2.95e-25 108.0 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,42PA6@68525|delta/epsilon subdivisions,2WIIY@28221|Deltaproteobacteria,2M858@213115|Desulfovibrionales 28221|Deltaproteobacteria U Belongs to the GSP D family - - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - BON,Secretin,T2SS-T3SS_pil_N k59_204078_2 1121939.L861_14185 6.55e-41 145.0 COG0111@1|root,COG0111@2|Bacteria,1NU4B@1224|Proteobacteria,1T1T1@1236|Gammaproteobacteria,1XRUW@135619|Oceanospirillales 135619|Oceanospirillales EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - 1.1.1.310 ko:K16843 ko00270,map00270 - R05693 RC00031 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_730279_1 1122201.AUAZ01000003_gene1871 1.58e-83 270.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,463XQ@72275|Alteromonadaceae 1236|Gammaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945 BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_1040975_1 1121921.KB898706_gene3423 1e-08 53.9 COG1254@1|root,COG1254@2|Bacteria 2|Bacteria C Belongs to the acylphosphatase family acyP GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase k59_1040975_2 926550.CLDAP_38640 6.31e-13 72.4 COG2084@1|root,COG2084@2|Bacteria,2G8J4@200795|Chloroflexi 200795|Chloroflexi C NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - - - - - - - - - - NAD_binding_11,NAD_binding_2 k59_779255_1 118163.Ple7327_1920 1.92e-23 99.0 COG1506@1|root,COG1506@2|Bacteria,1G200@1117|Cyanobacteria,3VJCM@52604|Pleurocapsales 1117|Cyanobacteria E WD40-like Beta Propeller Repeat dap2 - - - - - - - - - - - PD40,Peptidase_S9 k59_258277_1 1129794.C427_1822 3.31e-62 211.0 COG4772@1|root,COG4772@2|Bacteria,1MWDG@1224|Proteobacteria,1RQA5@1236|Gammaproteobacteria,4666K@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor fecA - - ko:K16091 - - - - ko00000,ko02000 1.B.14.1.14 - - Plug,TonB_dep_Rec k59_1040980_1 582402.Hbal_0633 5.32e-67 219.0 COG2234@1|root,COG2234@2|Bacteria,1MWBX@1224|Proteobacteria,2U2RE@28211|Alphaproteobacteria,43X5T@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Fibronectin type 3 domain - - - - - - - - - - - - Peptidase_M28 k59_626220_1 1242864.D187_007066 3.19e-41 148.0 COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria 1224|Proteobacteria S Metal-dependent hydrolase - - - - - - - - - - - - Cyclase k59_989856_1 159450.NH14_24340 4.86e-23 97.4 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2VHJK@28216|Betaproteobacteria,1K22I@119060|Burkholderiaceae 28216|Betaproteobacteria G Belongs to the phosphoglycerate kinase family pgk GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_989856_2 857087.Metme_3734 1.52e-24 102.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1XEMY@135618|Methylococcales 135618|Methylococcales G Belongs to the pyruvate kinase family - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_204144_1 754027.HMPREF9554_02773 3.15e-08 62.4 COG0553@1|root,COG4279@1|root,COG0553@2|Bacteria,COG4279@2|Bacteria,2J5VZ@203691|Spirochaetes 203691|Spirochaetes KL SNF2 family N-terminal domain - - - - - - - - - - - - DUF3670,Helicase_C,SNF2_N,SNF2_assoc,SWIM k59_1558652_1 1177928.TH2_07691 3.84e-57 197.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2UQAG@28211|Alphaproteobacteria,2JR6D@204441|Rhodospirillales 204441|Rhodospirillales V COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_730331_2 1123487.KB892857_gene2447 4.95e-25 101.0 COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,2VIJ5@28216|Betaproteobacteria,2KVP9@206389|Rhodocyclales 206389|Rhodocyclales O Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C_2,GST_N_3 k59_730338_1 997346.HMPREF9374_2249 2.77e-49 171.0 COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,4H9XK@91061|Bacilli,27B6V@186824|Thermoactinomycetaceae 91061|Bacilli E Histidinol dehydrogenase hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU34910 Histidinol_dh k59_989888_1 1038860.AXAP01000015_gene2094 7.03e-93 294.0 COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,2TU2E@28211|Alphaproteobacteria,3JRH2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G aldehyde-lyase activity xfp - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_1407085_2 760568.Desku_0639 3.89e-68 214.0 COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia,260V8@186807|Peptococcaceae 186801|Clostridia J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_1612556_2 118797.XP_007446525.1 1.33e-103 317.0 COG0468@1|root,KOG1433@2759|Eukaryota,3AI1H@33154|Opisthokonta,3BXPE@33208|Metazoa,3DE5Z@33213|Bilateria 33208|Metazoa L Mitochondrial DNA repair protein recA homolog - - - - - - - - - - - - RecA k59_630183_1 1232437.KL662001_gene4572 5.93e-21 95.1 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIX8@213118|Desulfobacterales 28221|Deltaproteobacteria T Sigma-54 interaction domain - - - ko:K07714,ko:K07715 ko02020,ko02024,map02020,map02024 M00500,M00502 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_472392_1 1089546.AQUI01000002_gene375 5.54e-46 158.0 COG1028@1|root,COG1028@2|Bacteria,2GNVA@201174|Actinobacteria,409QI@622450|Actinopolysporales 201174|Actinobacteria IQ KR domain - - - - - - - - - - - - adh_short,adh_short_C2 k59_368481_1 583345.Mmol_0550 1.64e-12 63.2 2EGIJ@1|root,33AAQ@2|Bacteria,1NH9B@1224|Proteobacteria,2W81A@28216|Betaproteobacteria,2KNAK@206350|Nitrosomonadales 206350|Nitrosomonadales S Protein of unknown function (DUF2909) - - - - - - - - - - - - DUF2909 k59_786825_1 323261.Noc_1210 5.37e-67 218.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1WWB1@135613|Chromatiales 135613|Chromatiales T SMART Nucleotide binding protein, PINc - - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_838513_1 404589.Anae109_2030 1.1e-139 428.0 COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,43CC6@68525|delta/epsilon subdivisions,2X7N2@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA k59_1256889_1 1198452.Jab_1c14630 8.09e-06 53.9 COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,2VJ44@28216|Betaproteobacteria,4725P@75682|Oxalobacteraceae 28216|Betaproteobacteria Q MlaD protein pqiB - - ko:K06192 - - - - ko00000 - - - MlaD k59_577178_2 436308.Nmar_0885 2.27e-29 105.0 arCOG10558@1|root,arCOG10558@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_577178_3 1229909.NSED_04960 4.43e-62 194.0 arCOG10557@1|root,arCOG10557@2157|Archaea,41T1I@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1308275_1 631362.Thi970DRAFT_02481 8.88e-44 154.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1WX16@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1308275_2 187272.Mlg_0342 2.15e-50 169.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_577180_1 525904.Tter_0396 6.96e-80 248.0 COG2141@1|root,COG2141@2|Bacteria,2NQM2@2323|unclassified Bacteria 2|Bacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_890875_1 313606.M23134_07367 9.85e-10 63.5 COG1061@1|root,COG1061@2|Bacteria,4NU9U@976|Bacteroidetes,47VJZ@768503|Cytophagia 976|Bacteroidetes F Helicase associated domain - - - - - - - - - - - - HA,Helicase_C,ResIII k59_890875_2 1123371.ATXH01000029_gene41 2.2e-59 200.0 COG0460@1|root,COG0460@2|Bacteria,2GH5Y@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_786840_1 870187.Thini_1687 9.55e-64 202.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,45ZWH@72273|Thiotrichales 72273|Thiotrichales I Enoyl- acyl-carrier-protein reductase NADH fabI - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_55586_1 557599.MKAN_03715 1.52e-57 204.0 COG0111@1|root,COG0235@1|root,COG1070@1|root,COG0111@2|Bacteria,COG0235@2|Bacteria,COG1070@2|Bacteria,2GIZV@201174|Actinobacteria,23EW1@1762|Mycobacteriaceae 201174|Actinobacteria EGH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - 1.1.1.399,1.1.1.95,2.7.1.189 ko:K00058,ko:K11216 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko02024,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map02024 M00020 R01513,R11183 RC00002,RC00017,RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,Aldolase_II,SCP2 k59_1622056_1 1268072.PSAB_00215 9.59e-38 142.0 COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,4HA0A@91061|Bacilli,26QBT@186822|Paenibacillaceae 91061|Bacilli S Protein containing tetrapyrrole methyltransferase domain and MazG-like yabN GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66 ko:K02428,ko:K02499 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000,ko03036 - - - MazG,TP_methylase k59_1516653_1 1122218.KB893653_gene424 3.75e-22 99.4 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2TRDM@28211|Alphaproteobacteria,1JS22@119045|Methylobacteriaceae 28211|Alphaproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_682435_1 436308.Nmar_0471 4.53e-134 401.0 COG1948@1|root,arCOG02284@2157|Archaea,41T0R@651137|Thaumarchaeota 651137|Thaumarchaeota L Beta propeller domain - - - - - - - - - - - - Beta_propel k59_890883_1 479434.Sthe_2960 1.56e-52 170.0 COG3795@1|root,COG3795@2|Bacteria,2G9DM@200795|Chloroflexi 200795|Chloroflexi S YCII-related domain - - - - - - - - - - - - YCII k59_1308291_1 556269.ACDQ01000006_gene1539 3.19e-06 55.5 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2VH1I@28216|Betaproteobacteria,472BF@75682|Oxalobacteraceae 28216|Betaproteobacteria M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_472417_1 243159.AFE_2122 3.98e-24 99.8 COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,1SYQK@1236|Gammaproteobacteria,2NCQ8@225057|Acidithiobacillales 225057|Acidithiobacillales M NmrA-like family - - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase k59_472417_2 105559.Nwat_1201 6.41e-55 183.0 COG0775@1|root,COG0775@2|Bacteria,1MY5S@1224|Proteobacteria,1RNSF@1236|Gammaproteobacteria,1WZQ1@135613|Chromatiales 135613|Chromatiales F other phosphorylase family 1 - - 3.2.2.9 ko:K01243 ko00270,ko01100,ko01230,map00270,map01100,map01230 M00034,M00609 R00194,R01401 RC00063,RC00318 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_472417_3 243233.MCA0812 4.24e-50 176.0 COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,1S118@1236|Gammaproteobacteria,1XDVD@135618|Methylococcales 135618|Methylococcales I Squalene cyclase - - 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 - R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 - - - SQHop_cyclase_C,SQHop_cyclase_N k59_1204766_1 1122197.ATWI01000011_gene314 1.09e-69 228.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1S1KY@1236|Gammaproteobacteria,465ZY@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG2230 Cyclopropane fatty acid synthase and related methyltransferases cfa2 - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_682450_1 1385517.N800_00715 5.93e-94 310.0 COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,1T4AK@1236|Gammaproteobacteria,1XDD9@135614|Xanthomonadales 135614|Xanthomonadales M Ompa motb domain protein - - - - - - - - - - - - - k59_1309147_1 357808.RoseRS_2496 3.04e-188 539.0 COG1274@1|root,COG1274@2|Bacteria,2G7VM@200795|Chloroflexi,374XU@32061|Chloroflexia 32061|Chloroflexia H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_264802_1 368407.Memar_0044 1.46e-40 148.0 COG3808@1|root,arCOG04949@2157|Archaea,2XTDB@28890|Euryarchaeota,2N98C@224756|Methanomicrobia 224756|Methanomicrobia C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_264802_2 1341151.ASZU01000008_gene1365 4e-25 102.0 COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,4H9SQ@91061|Bacilli,27BBQ@186824|Thermoactinomycetaceae 91061|Bacilli J Protein of unknown function (DUF933) ychF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_839371_1 1056820.KB900641_gene495 2.4e-94 293.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,2PNPK@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M Mechanosensitive ion channel VP2168 - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel k59_1622881_1 247634.GPB2148_313 3.71e-12 69.3 COG1520@1|root,COG4249@1|root,COG1520@2|Bacteria,COG4249@2|Bacteria,1QSQ3@1224|Proteobacteria,1RW8C@1236|Gammaproteobacteria,1JAW1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Caspase domain - - - - - - - - - - - - Peptidase_C14 k59_1622881_2 1123392.AQWL01000007_gene988 1.8e-20 83.6 COG3369@1|root,COG3369@2|Bacteria,1RCN9@1224|Proteobacteria 1224|Proteobacteria S PFAM Iron-binding zinc finger CDGSH type - - - - - - - - - - - - Fer4_19,Ferritin-like,zf-CDGSH k59_369305_1 743721.Psesu_1699 2.18e-154 452.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1X3W8@135614|Xanthomonadales 135614|Xanthomonadales IQ Activates fatty acids by binding to coenzyme A rpfB - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1517252_2 289376.THEYE_A0698 4.47e-13 67.4 COG0779@1|root,COG0779@2|Bacteria,3J0UD@40117|Nitrospirae 40117|Nitrospirae J Required for maturation of 30S ribosomal subunits rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_212485_1 880074.BARVI_07005 2.36e-39 144.0 COG1216@1|root,COG1216@2|Bacteria,4NJWR@976|Bacteroidetes,2G3FK@200643|Bacteroidia,22XRB@171551|Porphyromonadaceae 976|Bacteroidetes S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_943488_1 1125973.JNLC01000010_gene1288 2.51e-62 216.0 COG1028@1|root,COG2070@1|root,COG3321@1|root,COG1028@2|Bacteria,COG2070@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,2UR2U@28211|Alphaproteobacteria,3JZ58@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Ketoacyl-synthetase C-terminal extension - - - ko:K04786,ko:K13613 ko01053,map01053 - - - ko00000,ko00001,ko01004,ko01008 - - - Acyl_transf_1,Bac_luciferase,Condensation,ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,NMO,PP-binding,PS-DH,Thioesterase,ketoacyl-synt k59_631257_1 1380394.JADL01000011_gene3926 9.8e-62 201.0 COG0673@1|root,COG0673@2|Bacteria,1R4SZ@1224|Proteobacteria,2TRR2@28211|Alphaproteobacteria,2JV9S@204441|Rhodospirillales 204441|Rhodospirillales S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_264803_1 237368.SCABRO_03725 1.82e-166 478.0 COG1697@1|root,COG1697@2|Bacteria,2J34C@203682|Planctomycetes 203682|Planctomycetes L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6A - 5.99.1.3 ko:K03166 - - - - ko00000,ko01000,ko03032 - - - TP6A_N k59_264803_2 237368.SCABRO_03724 1.32e-165 483.0 COG1389@1|root,COG1389@2|Bacteria,2J2A8@203682|Planctomycetes 203682|Planctomycetes L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6B - 5.99.1.3 ko:K03167 - - - - ko00000,ko01000,ko03032 - - - HATPase_c,Topo-VIb_trans k59_578087_1 1366050.N234_20185 5.79e-65 214.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,1K01W@119060|Burkholderiaceae 28216|Betaproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_1257986_1 396588.Tgr7_0634 5.39e-102 306.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1WWRW@135613|Chromatiales 135613|Chromatiales C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_891756_1 459495.SPLC1_S033580 9.72e-93 291.0 COG2192@1|root,COG2192@2|Bacteria,1G1FV@1117|Cyanobacteria,1H9E9@1150|Oscillatoriales 1117|Cyanobacteria O carbamoyl transferase, NodU family - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_1205840_1 998674.ATTE01000001_gene4056 7.52e-34 135.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,4608C@72273|Thiotrichales 72273|Thiotrichales P Citrate transporter - - - - - - - - - - - - CitMHS,TrkA_C k59_1205842_1 744985.HIMB59_00004540 4.07e-134 400.0 COG1178@1|root,COG1178@2|Bacteria,1MXZZ@1224|Proteobacteria,2TT7F@28211|Alphaproteobacteria 28211|Alphaproteobacteria P ABC-type Fe3 transport system permease component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_683437_1 1123236.KB899377_gene145 4.87e-25 102.0 COG1999@1|root,COG1999@2|Bacteria,1RHSV@1224|Proteobacteria,1S6HW@1236|Gammaproteobacteria,46751@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems scoP - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_1570348_1 987059.RBXJA2T_06060 8.81e-23 97.8 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,1KJ5S@119065|unclassified Burkholderiales 28216|Betaproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_1570348_2 1026882.MAMP_02796 2.26e-08 53.5 COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,1SCYD@1236|Gammaproteobacteria,461I7@72273|Thiotrichales 72273|Thiotrichales NU Domain of unknown function (DUF4845) - - - - - - - - - - - - DUF4845,N_methyl k59_56646_1 351348.Maqu_3284 2.4e-06 55.5 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,465W0@72275|Alteromonadaceae 1236|Gammaproteobacteria NT COG0840 Methyl-accepting chemotaxis protein VPA0491 - - ko:K03406,ko:K05874 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,HBM,MCPsignal k59_107675_1 472759.Nhal_2468 2.86e-122 362.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1WVYA@135613|Chromatiales 135613|Chromatiales H TIGRFAM molybdenum cofactor synthesis - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1466411_1 1348114.OM33_17030 3.71e-06 53.5 COG2992@1|root,COG2992@2|Bacteria,1RD3U@1224|Proteobacteria,1S3RA@1236|Gammaproteobacteria,2Q2X0@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase - - - ko:K03796 - - - - ko00000 - GH73 - Glucosaminidase k59_1466411_3 466038.KI421440_gene75 1.18e-21 91.7 COG0071@1|root,COG0071@2|Bacteria,1R9Y1@1224|Proteobacteria,2UA1J@28211|Alphaproteobacteria,4BQNT@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O Belongs to the small heat shock protein (HSP20) family hspH - - ko:K04080 - - - - ko00000,ko03110 - - - HSP20 k59_943512_1 1207063.P24_07236 2.52e-166 477.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria,2JQSH@204441|Rhodospirillales 204441|Rhodospirillales G COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - - - - - - - - - - DctM k59_107682_1 436308.Nmar_0439 3.43e-22 89.4 COG1439@1|root,arCOG00721@2157|Archaea,41SPQ@651137|Thaumarchaeota 651137|Thaumarchaeota V PIN domain of ribonuclease - - - ko:K07060 - - - - ko00000,ko01000,ko02048 - - - PIN_6 k59_107682_2 436308.Nmar_0440 3e-103 304.0 COG0061@1|root,arCOG01348@2157|Archaea,41SHP@651137|Thaumarchaeota 651137|Thaumarchaeota H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP - - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_159172_1 639030.JHVA01000001_gene2815 1.5e-48 164.0 COG0500@1|root,COG2226@2|Bacteria,3Y6R8@57723|Acidobacteria,2JNYU@204432|Acidobacteriia 204432|Acidobacteriia Q Dimerisation domain - - - - - - - - - - - - Dimerisation2,Methyltransf_2 k59_473349_2 1192034.CAP_3449 1.06e-47 167.0 COG1362@1|root,COG1362@2|Bacteria,1NT1D@1224|Proteobacteria,42MN0@68525|delta/epsilon subdivisions,2WMBS@28221|Deltaproteobacteria,2YWEV@29|Myxococcales 28221|Deltaproteobacteria E M18 family aminopeptidase - - 3.4.11.21 ko:K01267 - - - - ko00000,ko01000,ko01002,ko04131 - - - Peptidase_M18 k59_212518_1 595537.Varpa_3624 9.72e-68 226.0 COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,4AAFY@80864|Comamonadaceae 28216|Betaproteobacteria H MoeA domain protein domain I and II - - 2.10.1.1 ko:K03750,ko:K07219 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_683460_1 1049564.TevJSym_cb00050 3.1e-56 198.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1J6D9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin,Thioredoxin_7 k59_631297_1 1108045.GORHZ_205_00240 2.86e-85 262.0 COG0596@1|root,COG0596@2|Bacteria,2I99I@201174|Actinobacteria,4GB8Z@85026|Gordoniaceae 201174|Actinobacteria S alpha/beta hydrolase fold dhaA - 3.8.1.5 ko:K01563 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_995671_1 331869.BAL199_00645 2.44e-100 305.0 COG3385@1|root,COG3385@2|Bacteria,1QURV@1224|Proteobacteria,2TW56@28211|Alphaproteobacteria,4BSI7@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L COG2183 Transcriptional accessory protein - - - - - - - - - - - - DDE_Tnp_1_4 k59_525871_2 1499967.BAYZ01000056_gene4882 1.06e-77 261.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K07713,ko:K07714 ko02020,map02020 M00499,M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PEP_hydrolase,Sigma54_activat k59_1205887_1 330214.NIDE1205 2.14e-90 278.0 COG0439@1|root,COG0439@2|Bacteria,3J0YP@40117|Nitrospirae 40117|Nitrospirae I Biotin carboxylase C-terminal domain - - 6.4.1.1 ko:K01959 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_525881_1 261292.Nit79A3_1901 2.4e-104 316.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,372DK@32003|Nitrosomonadales 28216|Betaproteobacteria J Ribonuclease E/G family cafA - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_369361_1 318167.Sfri_2018 6.74e-63 203.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,2QAIT@267890|Shewanellaceae 1236|Gammaproteobacteria K Transcriptional regulator, Crp Fnr family fnr GO:0000302,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009061,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015980,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0042221,GO:0042493,GO:0043565,GO:0044212,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0045893,GO:0045935,GO:0048037,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_264854_1 580340.Tlie_1655 3.23e-09 57.4 COG0451@1|root,COG0451@2|Bacteria,3T9U6@508458|Synergistetes 508458|Synergistetes M NAD dependent epimerase dehydratase family - - - - - - - - - - - - Epimerase k59_264854_2 477974.Daud_0472 5.83e-43 153.0 COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,260IY@186807|Peptococcaceae 186801|Clostridia M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1,5.1.1.18 ko:K01775,ko:K18348 ko00473,ko01100,ko01502,ko02020,map00473,map01100,map01502,map02020 M00652 R00401 RC00285 ko00000,ko00001,ko00002,ko01000,ko01011,ko01504 - - - Ala_racemase_C,Ala_racemase_N k59_56681_1 1121918.ARWE01000001_gene2505 1.4e-163 482.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,42YX3@68525|delta/epsilon subdivisions,2WTY2@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Phosphoenolpyruvate phosphomutase - - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_421547_1 330214.NIDE4238 9.57e-135 404.0 COG0495@1|root,COG0495@2|Bacteria,3J0F8@40117|Nitrospirae 40117|Nitrospirae J Leucyl-tRNA synthetase, Domain 2 leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1 k59_1466442_1 330214.NIDE1304 2.19e-127 398.0 COG0086@1|root,COG0086@2|Bacteria,3J0BT@40117|Nitrospirae 40117|Nitrospirae K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_264856_1 391615.ABSJ01000054_gene1405 2.14e-58 199.0 COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1J5ET@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Phosphate acyltransferases aas - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - Acyltransferase,MFS_1 k59_1309229_1 314285.KT71_04350 9.84e-33 128.0 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,1SKMW@1236|Gammaproteobacteria,1J9PK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_787968_1 398767.Glov_2008 2.78e-51 174.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria 1224|Proteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072,ko:K03074,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_1048362_1 545276.KB898724_gene2063 4.69e-35 132.0 COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1X2EG@135613|Chromatiales 135613|Chromatiales P PUA-like domain - - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,ATP-sulfurylase,PUA_2 k59_1048362_2 34506.g816 6.02e-19 85.5 COG0621@1|root,KOG2492@2759|Eukaryota,39W8Q@33154|Opisthokonta,3BFMT@33208|Metazoa,3DD6H@33213|Bilateria,40QX1@6231|Nematoda,1M7UH@119089|Chromadorea,4171R@6236|Rhabditida 33208|Metazoa T Uncharacterized protein family UPF0004 - - - - - - - - - - - - PhoH,Radical_SAM,TRAM,UPF0004 k59_585214_2 1111732.AZOD01000002_gene1737 6.51e-09 52.4 2EG8N@1|root,33A0G@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_797561_2 316067.Geob_2070 4.82e-51 169.0 COG0500@1|root,COG2226@2|Bacteria,1MVIS@1224|Proteobacteria,42VMX@68525|delta/epsilon subdivisions,2WS5W@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q ubiE/COQ5 methyltransferase family - - 2.1.1.17,2.1.1.71 ko:K00570 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00091 R01320,R02056,R03424 RC00003,RC00060,RC00181,RC00496 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_741833_1 1329516.JPST01000003_gene1053 5.03e-55 196.0 COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,4H9UP@91061|Bacilli,27B5P@186824|Thermoactinomycetaceae 91061|Bacilli L Single-strand DNA-specific exonuclease, C terminal domain recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1,ssDNA-exonuc_C k59_846574_1 1207063.P24_07579 3.47e-75 239.0 COG2271@1|root,COG2271@2|Bacteria,1QU9E@1224|Proteobacteria,2TWHH@28211|Alphaproteobacteria,2JR0J@204441|Rhodospirillales 204441|Rhodospirillales G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1577279_1 444860.E3SJ64_9CAUD 4.66e-08 54.3 4QC2G@10239|Viruses,4QV3V@35237|dsDNA viruses no RNA stage,4QPRR@28883|Caudovirales,4QI1T@10662|Myoviridae 10662|Myoviridae S Ribonucleotide reductase, small chain - - - - - - - - - - - - - k59_1577279_2 869724.H6BIE3_9CAUD 5.83e-103 320.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QI6A@10662|Myoviridae 10662|Myoviridae S Ribonucleotide reductase, barrel domain - - - - - - - - - - - - - k59_219708_1 448385.sce5399 5.45e-17 86.7 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,42MSB@68525|delta/epsilon subdivisions,2WJI6@28221|Deltaproteobacteria,2YWRH@29|Myxococcales 28221|Deltaproteobacteria L OB-fold nucleic acid binding domain - - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_1107923_1 1229780.BN381_430052 2.59e-10 61.2 COG2267@1|root,COG2267@2|Bacteria,2GYP0@201174|Actinobacteria 201174|Actinobacteria I Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) menH - 4.2.99.20 ko:K08680 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08166 RC02148,RC02475 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_6 k59_1107923_2 1437425.CSEC_0853 5.1e-40 140.0 COG0447@1|root,COG0447@2|Bacteria,2JFGT@204428|Chlamydiae 204428|Chlamydiae H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) menB - 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1475321_1 519989.ECTPHS_13113 2.06e-48 156.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,1S973@1236|Gammaproteobacteria,1WYKG@135613|Chromatiales 135613|Chromatiales J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_1475321_2 765910.MARPU_03780 7.97e-94 277.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,1WW32@135613|Chromatiales 135613|Chromatiales J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_1475321_3 113355.CM001775_gene1967 0.000494 41.2 COG0199@1|root,COG0199@2|Bacteria,1G6JZ@1117|Cyanobacteria 1117|Cyanobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_640543_1 1340493.JNIF01000003_gene3662 1.19e-36 133.0 COG0558@1|root,COG0558@2|Bacteria,3Y427@57723|Acidobacteria 57723|Acidobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_219716_1 330214.NIDE3719 6.52e-71 221.0 COG1189@1|root,COG1189@2|Bacteria,3J0MD@40117|Nitrospirae 40117|Nitrospirae J FtsJ-like methyltransferase - - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k59_165382_1 1282876.BAOK01000002_gene892 3.31e-50 174.0 COG0477@1|root,COG0477@2|Bacteria,1R02N@1224|Proteobacteria,2TYHV@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_481601_1 85643.Tmz1t_1151 2.09e-104 335.0 COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2WGGY@28216|Betaproteobacteria,2KVF7@206389|Rhodocyclales 206389|Rhodocyclales V ABC-type multidrug transport system, ATPase component - - - ko:K13926 - - - - ko00000 - - - ABC2_membrane_3,ABC_tran k59_1421736_1 227086.JGI_V11_130919 1.29e-45 168.0 2EJSG@1|root,2SPVR@2759|Eukaryota 2759|Eukaryota - - - - - - - - - - - - - - - k59_899027_1 1333856.L686_09670 3.26e-50 177.0 COG0591@1|root,COG0591@2|Bacteria,1PNHU@1224|Proteobacteria,1S0S6@1236|Gammaproteobacteria,1Z1NY@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_1002749_1 1122929.KB908221_gene2817 4.07e-30 117.0 COG3219@1|root,COG3219@2|Bacteria,1QAP4@1224|Proteobacteria,2TTIN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Putative DNA-binding domain - - - - - - - - - - - - DUF2063 k59_1630387_1 880070.Cycma_2544 1.67e-65 208.0 COG4181@1|root,COG4181@2|Bacteria,4NEVZ@976|Bacteroidetes,47JSN@768503|Cytophagia 976|Bacteroidetes Q ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_376713_1 1246448.ANAZ01000059_gene19 4.29e-08 59.3 COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4ENJG@85012|Streptosporangiales 201174|Actinobacteria Q Multicopper oxidase - - - ko:K04753 - - - - ko00000 - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_640577_1 292415.Tbd_0869 7.08e-137 392.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2VHWI@28216|Betaproteobacteria 28216|Betaproteobacteria S ATPase associated with various cellular activities, AAA_5 - - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5,CbbQ_C k59_1475361_2 1479235.KK366039_gene915 5.23e-12 64.7 COG0596@1|root,COG0596@2|Bacteria,1N5ZI@1224|Proteobacteria,1S3RK@1236|Gammaproteobacteria,1XMDZ@135619|Oceanospirillales 135619|Oceanospirillales S hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_1 k59_1630398_1 697282.Mettu_1903 2.37e-60 204.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1XE7K@135618|Methylococcales 135618|Methylococcales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_797617_2 1038859.AXAU01000003_gene6201 1.35e-132 382.0 COG0411@1|root,COG0411@2|Bacteria,1NP6N@1224|Proteobacteria,2U27F@28211|Alphaproteobacteria,3K5XU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E ATPases associated with a variety of cellular activities - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_219745_1 436308.Nmar_1368 1.13e-100 298.0 COG0457@1|root,arCOG03038@2157|Archaea,41SMV@651137|Thaumarchaeota 651137|Thaumarchaeota S Transglutaminase-like superfamily - - - - - - - - - - - - TPR_9,Transglut_core2 k59_1475366_2 944547.ABLL_0972 9.99e-100 302.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,42RH4@68525|delta/epsilon subdivisions,2YRC8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C is mostly active on D-proline, and to a lesser extent, on several other D-amino acids such as D- alanine, D-phenylalanine and D-serine. Mediates electron transport from D-proline to coenzyme Q1 in vitro, and is involved in the electron transport chain from D-proline to the c-type cytochrome in vivo - - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_1368906_1 1535422.ND16A_0545 8.23e-69 224.0 COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria 1236|Gammaproteobacteria CP PFAM NADH Ubiquinone plastoquinone (complex I) - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M,Proton_antipo_N k59_114614_1 232721.Ajs_3062 8.13e-59 195.0 COG0558@1|root,COG0558@2|Bacteria,1MYE7@1224|Proteobacteria,2WEA8@28216|Betaproteobacteria 28216|Betaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - - - - - - - - - - CDP-OH_P_transf k59_846616_1 502025.Hoch_3482 1.77e-09 57.4 2BPA6@1|root,32I21@2|Bacteria,1Q1NP@1224|Proteobacteria,437D0@68525|delta/epsilon subdivisions,2X2J2@28221|Deltaproteobacteria,2YVZ4@29|Myxococcales 28221|Deltaproteobacteria S Cytosol aminopeptidase family, N-terminal domain - - - - - - - - - - - - Peptidase_M17_N k59_846616_2 767817.Desgi_2610 2.21e-26 103.0 COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,24MQ3@186801|Clostridia,26201@186807|Peptococcaceae 186801|Clostridia K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_846616_3 926692.AZYG01000034_gene2369 1.3e-43 148.0 COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,24FRS@186801|Clostridia,3WAMS@53433|Halanaerobiales 186801|Clostridia H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH - 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k59_846616_4 1121861.KB899938_gene4011 1.87e-10 63.9 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2TR70@28211|Alphaproteobacteria,2JPG9@204441|Rhodospirillales 204441|Rhodospirillales H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_1055709_1 1224164.B843_05535 5.88e-22 99.4 COG1969@1|root,COG1969@2|Bacteria,2GUTZ@201174|Actinobacteria,22KM3@1653|Corynebacteriaceae 201174|Actinobacteria C Ni Fe-hydrogenase, b-type cytochrome subunit cybH - - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Ni_hydr_CYTB k59_950481_1 1121033.AUCF01000011_gene1738 2.1e-07 53.1 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,2JQVG@204441|Rhodospirillales 204441|Rhodospirillales O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_691702_1 292415.Tbd_0727 3.52e-126 371.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2VHAR@28216|Betaproteobacteria,1KRAB@119069|Hydrogenophilales 119069|Hydrogenophilales G Glycosyl hydrolase family 3 N terminal domain - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_376742_1 1227349.C170_20620 2.38e-06 50.1 COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,4HAPM@91061|Bacilli,26QYD@186822|Paenibacillaceae 91061|Bacilli G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_846624_1 368407.Memar_0759 8.01e-38 139.0 COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,2N940@224756|Methanomicrobia 224756|Methanomicrobia M PFAM NAD-dependent epimerase dehydratase - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - iAF692.Mbar_A0021 Epimerase,GDP_Man_Dehyd k59_846624_2 228410.NE0622 3.64e-05 44.3 COG0662@1|root,COG0662@2|Bacteria,1RFTK@1224|Proteobacteria,2WG1F@28216|Betaproteobacteria,374QB@32003|Nitrosomonadales 28216|Betaproteobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 k59_532956_1 1123368.AUIS01000014_gene2302 8.55e-96 293.0 COG1524@1|root,COG1524@2|Bacteria,1P235@1224|Proteobacteria,1SZYR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_1475390_1 985665.HPL003_25435 1.07e-23 98.2 COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,4H9WF@91061|Bacilli,26SJF@186822|Paenibacillaceae 91061|Bacilli S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113 - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_1475390_2 944480.ATUV01000002_gene364 4.99e-05 46.2 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,2M6CS@213113|Desulfurellales 28221|Deltaproteobacteria P MgtE intracellular N domain mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_1522081_1 246200.SPO1494 2e-61 206.0 COG3917@1|root,COG3917@2|Bacteria,1MV6E@1224|Proteobacteria,2TVJ4@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q 2-hydroxychromene-2-carboxylate isomerase - - - - - - - - - - - - DSBA k59_585292_1 330214.NIDE3296 4.42e-112 338.0 COG1271@1|root,COG1271@2|Bacteria 2|Bacteria C aerobic electron transport chain - - 1.10.3.14 ko:K00425,ko:K08738 ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00153,M00595 R10151,R11325 RC00061,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.3,3.D.4.6 - - Cyt_bd_oxida_I,Cytochrome_CBB3 k59_1267358_1 287.DR97_1975 2.1e-69 225.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1YCZH@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008883,GO:0009058,GO:0009064,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_1375,iECSF_1327.ECSF_1186,iUTI89_1310.UTI89_C1404 GlutR_N,GlutR_dimer,Shikimate_DH k59_532968_1 314231.FP2506_13339 9.81e-49 166.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2PKH2@255475|Aurantimonadaceae 28211|Alphaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_532968_2 1458357.BG58_21650 1.9e-31 117.0 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,1K3K2@119060|Burkholderiaceae 28216|Betaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_1421812_2 326427.Cagg_0347 1.36e-07 53.5 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,2G65G@200795|Chloroflexi,374V3@32061|Chloroflexia 32061|Chloroflexia I PFAM Enoyl-CoA hydratase isomerase - - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1,ECH_2 k59_1522089_1 543632.JOJL01000001_gene7797 2.32e-12 70.5 COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria,4DHKU@85008|Micromonosporales 201174|Actinobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_899079_1 469610.HMPREF0189_00832 3.35e-26 105.0 COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2VHHT@28216|Betaproteobacteria,1KM1H@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_899079_2 1423144.Gal_00469 1.21e-09 61.2 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2TUF7@28211|Alphaproteobacteria,34ETF@302485|Phaeobacter 28211|Alphaproteobacteria I CDP-alcohol phosphatidyltransferase pssA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_tran_2,CDP-OH_P_transf k59_640644_1 797299.HALLA_14570 0.000564 47.8 COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,23TKK@183963|Halobacteria 183963|Halobacteria L Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange radB - - ko:K04484 - - - - ko00000,ko03400 - - - Rad51 k59_797677_2 3055.EDP06455 7.29e-07 51.6 COG1063@1|root,KOG0024@2759|Eukaryota,37YJ9@33090|Viridiplantae,34JGM@3041|Chlorophyta 3041|Chlorophyta Q Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_1108010_2 1283300.ATXB01000002_gene3020 2.95e-20 95.9 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1XEH5@135618|Methylococcales 135618|Methylococcales U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_1159412_1 488538.SAR116_0663 3.22e-60 196.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,4BQAI@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Rhomboid family - - - - - - - - - - - - Rhomboid k59_1159412_2 1123234.AUKI01000013_gene1552 5.79e-59 189.0 COG0207@1|root,COG0207@2|Bacteria,4NEC2@976|Bacteroidetes,1HX2F@117743|Flavobacteriia 976|Bacteroidetes F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_1630449_1 1121094.KB894644_gene2116 8.77e-14 79.3 COG0553@1|root,COG0553@2|Bacteria,4NKAA@976|Bacteroidetes,2G2ZK@200643|Bacteroidia 976|Bacteroidetes KL SWIM zinc finger domain protein - - - - - - - - - - - - Helicase_C,SNF2_N k59_376769_2 631362.Thi970DRAFT_01944 3.98e-61 194.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria,1WWG3@135613|Chromatiales 135613|Chromatiales K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_376769_3 1121413.JMKT01000004_gene973 1.2e-09 56.2 COG0690@1|root,COG0690@2|Bacteria,1Q1BI@1224|Proteobacteria,42X4Z@68525|delta/epsilon subdivisions,2WSQ8@28221|Deltaproteobacteria,2MD79@213115|Desulfovibrionales 28221|Deltaproteobacteria U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE k59_585320_1 330214.NIDE3255 7.9e-93 299.0 COG0243@1|root,COG0243@2|Bacteria 2|Bacteria C molybdopterin cofactor binding ddhA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4 ko:K00370,ko:K10700,ko:K16964,ko:K17050 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_1268235_1 345341.KUTG_00801 8.99e-35 130.0 COG1237@1|root,COG1237@2|Bacteria,2I8H7@201174|Actinobacteria,4DZYW@85010|Pseudonocardiales 201174|Actinobacteria S Metallo-beta-lactamase superfamily - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - Lactamase_B k59_1369567_1 883126.HMPREF9710_04313 2.06e-07 58.5 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,473Z1@75682|Oxalobacteraceae 28216|Betaproteobacteria C Succinyl-CoA ligase like flavodoxin domain - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_377415_1 379066.GAU_3602 2.91e-38 146.0 COG5549@1|root,COG5549@2|Bacteria,1ZTC4@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Domain of unknown function (DUF5118) - - - - - - - - - - - - DUF4953,DUF5117,DUF5118 k59_1369569_1 1232437.KL662031_gene2543 3.98e-21 94.7 COG2367@1|root,COG2367@2|Bacteria,1R6KF@1224|Proteobacteria,42YYI@68525|delta/epsilon subdivisions,2WTQR@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Beta-lactamase enzyme family - - 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2 k59_899779_1 330214.NIDE3049 3.36e-61 203.0 COG1078@1|root,COG1078@2|Bacteria,3J0YB@40117|Nitrospirae 40117|Nitrospirae S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06885 - - - - ko00000 - - - HD k59_1056467_1 28229.ND2E_4292 2.4e-44 164.0 COG0784@1|root,COG2202@1|root,COG2703@1|root,COG3829@1|root,COG3852@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2703@2|Bacteria,COG3829@2|Bacteria,COG3852@2|Bacteria,1NC9X@1224|Proteobacteria,1T242@1236|Gammaproteobacteria 1236|Gammaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_1108739_1 331678.Cphamn1_1986 8.91e-65 213.0 COG1290@1|root,COG1290@2|Bacteria,1FD8I@1090|Chlorobi 1090|Chlorobi C PFAM Cytochrome b b6 - - - ko:K02635 ko00195,ko01100,map00195,map01100 M00162 - - ko00000,ko00001,ko00002,ko00194 - - - Cytochrom_B_C,Cytochrome_B k59_1160009_1 1265313.HRUBRA_02632 2.27e-42 159.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1J4E5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Cation transporter/ATPase, N-terminus ctpF - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_586043_1 1122604.JONR01000001_gene1979 1.12e-50 183.0 COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1X6T3@135614|Xanthomonadales 135614|Xanthomonadales KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,HAMP,Pkinase,sCache_3_2 k59_641514_1 545264.KB898753_gene1780 3e-49 164.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,1WX1J@135613|Chromatiales 135613|Chromatiales I Enoyl- acyl-carrier-protein reductase NADH - - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_641514_2 1266925.JHVX01000010_gene1324 1.01e-46 168.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,371M3@32003|Nitrosomonadales 28216|Betaproteobacteria E extracellular solute-binding protein, family 5 oppA - - - - - - - - - - - SBP_bac_5 k59_1003558_1 1380394.JADL01000006_gene5324 2.68e-54 189.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,2JPIV@204441|Rhodospirillales 204441|Rhodospirillales I COG1960 Acyl-CoA dehydrogenases - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_1003561_1 1121875.KB907549_gene1918 5.61e-47 161.0 2C3WA@1|root,2Z8P1@2|Bacteria,4NW8R@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1003564_1 1306174.JODP01000009_gene6322 5.98e-37 139.0 COG0635@1|root,COG0635@2|Bacteria,2GJXX@201174|Actinobacteria 201174|Actinobacteria H Involved in the biosynthesis of porphyrin-containing compound hemN GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - iNJ661.Rv2388c HemN_C,Radical_SAM k59_1583872_2 290400.Jann_3194 2.27e-12 67.4 2CK2Q@1|root,303GN@2|Bacteria,1RG44@1224|Proteobacteria,2U8BW@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1009295_2 744980.TRICHSKD4_0658 1.42e-05 49.7 COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2UC0F@28211|Alphaproteobacteria 28211|Alphaproteobacteria S CBS domain - - - - - - - - - - - - CBS k59_1637417_1 998088.B565_1656 5.85e-19 90.1 COG0745@1|root,COG0784@1|root,COG2198@1|root,COG4251@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG4251@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1Y52I@135624|Aeromonadales 135624|Aeromonadales T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg k59_1637417_2 1502851.FG93_00180 2.73e-16 80.9 COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,2U2BQ@28211|Alphaproteobacteria,3JWN1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T PFAM adenylyl cyclase class-3 4 guanylyl cyclase MA20_06330 - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - DUF3365,Guanylate_cyc,HAMP,Response_reg k59_74294_1 1479235.KK366039_gene2492 3.17e-18 82.8 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1XH9U@135619|Oceanospirillales 135619|Oceanospirillales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_74294_2 396588.Tgr7_2300 3.78e-82 248.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,1WW34@135613|Chromatiales 135613|Chromatiales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_435378_1 1123073.KB899241_gene2588 1.9e-25 105.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1XCHU@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_435378_2 335283.Neut_1829 1.26e-57 186.0 COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2VH27@28216|Betaproteobacteria,371V1@32003|Nitrosomonadales 28216|Betaproteobacteria G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A,Sugar-bind k59_122488_1 1123255.JHYS01000004_gene966 3.33e-113 330.0 COG4420@1|root,COG4420@2|Bacteria,1RIDY@1224|Proteobacteria,2VRHY@28216|Betaproteobacteria,4AFE9@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1003) - - - - - - - - - - - - DUF1003 k59_226060_1 522306.CAP2UW1_0774 1.13e-46 165.0 COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,1KQI1@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M D-alanyl-D-alanine carboxypeptidase pbpG - - ko:K07262 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S11 k59_905458_1 1397666.RS24_00104 1.09e-42 158.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_171569_1 575540.Isop_0406 1.56e-30 123.0 COG0619@1|root,COG0619@2|Bacteria 2|Bacteria P transmembrane transporter activity ecfT GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0022857,GO:0032217,GO:0032218,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0098656 - ko:K02008,ko:K16783,ko:K16785 ko02010,map02010 M00245,M00246,M00581,M00582 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - CbiQ k59_806041_1 391615.ABSJ01000054_gene1475 1.59e-59 199.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1J4XQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_122493_1 1266925.JHVX01000003_gene449 2.88e-58 198.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,372IA@32003|Nitrosomonadales 28216|Betaproteobacteria V ABC transporter transmembrane region atm1 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1114301_1 356851.JOAN01000003_gene1539 3.93e-28 118.0 COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4DA3Q@85008|Micromonosporales 201174|Actinobacteria EH Belongs to the TPP enzyme family ilvG GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv1820 TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_490152_2 58123.JOFJ01000003_gene2256 2.54e-44 159.0 COG3670@1|root,COG3670@2|Bacteria,2IN1D@201174|Actinobacteria 201174|Actinobacteria Q Retinal pigment epithelial membrane protein - - - - - - - - - - - - RPE65 k59_1221429_6 313624.NSP_52060 3.62e-08 55.1 COG0234@1|root,COG0234@2|Bacteria,1G6J1@1117|Cyanobacteria,1HP0T@1161|Nostocales 1117|Cyanobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_74310_1 187272.Mlg_1883 1.56e-58 193.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria,1WXIF@135613|Chromatiales 135613|Chromatiales S associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_806047_1 1198232.CYCME_0830 1.18e-97 296.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,45ZV4@72273|Thiotrichales 72273|Thiotrichales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_748175_1 1502770.JQMG01000001_gene1053 5.13e-100 306.0 COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,2VII5@28216|Betaproteobacteria,2KMFT@206350|Nitrosomonadales 206350|Nitrosomonadales H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,CbiA,GATase_3 k59_591627_2 1121937.AUHJ01000003_gene3224 5.16e-60 202.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,464IQ@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_648967_1 519989.ECTPHS_12438 5.92e-91 279.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1WW7C@135613|Chromatiales 135613|Chromatiales E Belongs to the aspartokinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_278793_1 330214.NIDE2451 3.23e-87 267.0 COG0372@1|root,COG0372@2|Bacteria 2|Bacteria C Belongs to the citrate synthase family gltA - 2.3.3.1,2.3.3.5 ko:K01647,ko:K01659 ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351,R00931 RC00004,RC00067,RC00406,RC02827 br01601,ko00000,ko00001,ko00002,ko01000 - - iJN678.gltA Citrate_synt k59_698107_1 1123278.KB893614_gene5279 3.69e-18 83.6 COG1515@1|root,COG1515@2|Bacteria,4NI4J@976|Bacteroidetes,47KIS@768503|Cytophagia 976|Bacteroidetes L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA nfi - 3.1.21.7 ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 k59_698107_2 1150469.RSPPHO_01888 8.59e-59 206.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,2JPTT@204441|Rhodospirillales 204441|Rhodospirillales C COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1637438_1 1205680.CAKO01000030_gene4841 8.88e-128 374.0 COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2U1CT@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_490179_1 420662.Mpe_A3264 1.78e-47 166.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2VKR6@28216|Betaproteobacteria,1KIXT@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Formate--tetrahydrofolate ligase fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_490179_2 765910.MARPU_00035 5.18e-40 150.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1WW2F@135613|Chromatiales 135613|Chromatiales P Chloride channel - - - - - - - - - - - - Voltage_CLC k59_1375122_1 1169154.KB897777_gene3659 4.58e-14 76.6 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria 201174|Actinobacteria Q cytochrome p450 cyp20 - 1.14.14.1 ko:K00493 ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120 - R03629,R04121,R05259 RC00046,RC01311 ko00000,ko00001,ko01000 - - - p450 k59_1430035_1 314278.NB231_09623 7.19e-71 228.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1T3U5@1236|Gammaproteobacteria,1X1MF@135613|Chromatiales 135613|Chromatiales M Putative transposase - - - - - - - - - - - - Y2_Tnp k59_1526415_1 545276.KB898732_gene2404 1.91e-84 260.0 COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1WWNR@135613|Chromatiales 135613|Chromatiales M Belongs to the NAD(P)-dependent epimerase dehydratase family - - 5.1.3.2,5.1.3.5 ko:K01784,ko:K12448 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R01473,R02984 RC00289,RC00528 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_74350_1 555387.C7BUY8_9CAUD 3.41e-74 231.0 4QI8Q@10662|Myoviridae 10662|Myoviridae S photosynthetic electron transport in photosystem II - - - - - - - - - - - - - k59_74350_2 869662.M4PMI0_9CAUD 1.71e-67 213.0 4QAWJ@10239|Viruses,4QVR5@35237|dsDNA viruses no RNA stage,4QQRJ@28883|Caudovirales,4QI8Q@10662|Myoviridae 10662|Myoviridae S photosynthetic electron transport in photosystem II - - - - - - - - - - - - - k59_171595_1 521674.Plim_1742 1.32e-137 405.0 COG0422@1|root,COG0422@2|Bacteria,2IWV7@203682|Planctomycetes 203682|Planctomycetes H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC_Rad_SAM k59_1062434_2 330214.NIDE0428 4.05e-42 139.0 COG0776@1|root,COG0776@2|Bacteria,3J19J@40117|Nitrospirae 40117|Nitrospirae L bacterial (prokaryotic) histone like domain - - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_1062434_3 1462527.CCDM010000003_gene4045 0.000682 42.4 COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,4HAM2@91061|Bacilli,23JXM@182709|Oceanobacillus 91061|Bacilli J Histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA-synt_His k59_1583929_1 314230.DSM3645_01826 1.19e-76 244.0 COG0464@1|root,COG0464@2|Bacteria,2IX7A@203682|Planctomycetes 203682|Planctomycetes O growth - - - - - - - - - - - - - k59_853935_1 926560.KE387023_gene2721 8.09e-103 312.0 COG0232@1|root,COG0232@2|Bacteria,1WI39@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus F Belongs to the dGTPase family. Type 2 subfamily - GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_699009_1 1163617.SCD_n02930 4.1e-81 250.0 COG0714@1|root,COG0714@2|Bacteria,1PHW4@1224|Proteobacteria,2VRJN@28216|Betaproteobacteria 28216|Betaproteobacteria S associated with various cellular activities - - - - - - - - - - - - AAA,AAA_5 k59_906366_1 1333856.L686_16705 1.49e-49 162.0 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,1Z295@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria K Belongs to the MraZ family mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - ko:K03925 - - - - ko00000 - - - MraZ k59_1115197_1 2340.JV46_02620 2.14e-10 60.5 COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,1RQ0M@1236|Gammaproteobacteria,1JA3Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Prolyl 4-hydroxylase alpha subunit homologues. ybiX - - ko:K07336 - - - - ko00000,ko01000 - - - 2OG-FeII_Oxy_3 k59_1115197_2 396588.Tgr7_2180 4.62e-21 84.7 2C2HW@1|root,32U3B@2|Bacteria,1N2W5@1224|Proteobacteria,1SA05@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1115197_3 765913.ThidrDRAFT_2040 8.97e-37 127.0 COG2920@1|root,COG2920@2|Bacteria,1RISY@1224|Proteobacteria,1S8HB@1236|Gammaproteobacteria,1WYQ6@135613|Chromatiales 135613|Chromatiales P Part of a sulfur-relay system - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_1115197_4 870187.Thini_3763 1.05e-34 127.0 2CARE@1|root,2Z8Q5@2|Bacteria,1R7S8@1224|Proteobacteria,1RRAH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S TIGRFAM CRISPR-associated protein - - - - - - - - - - - - Cas6 k59_1638036_1 1128421.JAGA01000003_gene3714 6.75e-80 264.0 COG0542@1|root,COG0542@2|Bacteria,2NNNE@2323|unclassified Bacteria 2|Bacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - ko:K03694,ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1638036_2 762903.Pedsa_1506 9.84e-09 52.8 COG3360@1|root,COG3360@2|Bacteria,4NURJ@976|Bacteroidetes,1IU3M@117747|Sphingobacteriia 976|Bacteroidetes S Dodecin - - - ko:K09165 - - - - ko00000 - - - Dodecin k59_1277112_1 314345.SPV1_01487 1.35e-14 73.6 293CN@1|root,2ZQV6@2|Bacteria,1RDZB@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_172246_1 1254432.SCE1572_34500 8.65e-08 58.9 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - Alpha-amylase,Big_2,CBM_25,Calx-beta,DUF4114,P_proprotein,Peptidase_S8,SBBP,SLH,VCBS k59_123694_1 555778.Hneap_2202 6.9e-89 276.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1WWMQ@135613|Chromatiales 135613|Chromatiales C PFAM Aldehyde dehydrogenase - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1222577_1 1122603.ATVI01000005_gene3586 4.55e-13 75.5 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1X3WY@135614|Xanthomonadales 135614|Xanthomonadales M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_D23 k59_385998_1 1303518.CCALI_00772 7.59e-13 67.8 COG0473@1|root,COG0473@2|Bacteria 2|Bacteria CE 3-isopropylmalate dehydrogenase activity icd - 1.1.1.41 ko:K00030 ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00709 RC00114 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_385998_2 1382359.JIAL01000001_gene2461 3.7e-26 108.0 COG0484@1|root,COG0484@2|Bacteria,3Y2XW@57723|Acidobacteria,2JHWV@204432|Acidobacteriia 204432|Acidobacteriia O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_957623_1 1219035.NT2_03_00580 2.83e-78 246.0 COG0596@1|root,COG0596@2|Bacteria,1MWVN@1224|Proteobacteria,2TQVB@28211|Alphaproteobacteria,2K2FR@204457|Sphingomonadales 204457|Sphingomonadales I epoxide hydrolase - - - - - - - - - - - - EHN k59_1063326_1 1088721.NSU_3018 9.44e-31 120.0 COG0637@1|root,COG1877@1|root,COG0637@2|Bacteria,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2VFA5@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Removes the phosphate from trehalose 6-phosphate to produce free trehalose - - 3.1.3.12 ko:K01087 ko00500,ko01100,map00500,map01100 - R02778 RC00017 ko00000,ko00001,ko01000 - - - HAD_2,Trehalose_PPase k59_1063326_2 232721.Ajs_2162 5.62e-27 109.0 COG1554@1|root,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,2VK07@28216|Betaproteobacteria 28216|Betaproteobacteria G Glycosyl hydrolase family 65 central catalytic domain protein - - 2.4.1.64,2.4.1.8 ko:K00691,ko:K05342 ko00500,ko01100,map00500,map01100 - R01555,R02727 RC00049 ko00000,ko00001,ko01000 - GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m k59_386006_1 298655.KI912266_gene4261 1.34e-44 155.0 COG1960@1|root,COG1960@2|Bacteria,2GK9C@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_279699_1 394.NGR_c10630 1.39e-85 266.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2TQMX@28211|Alphaproteobacteria,4BABT@82115|Rhizobiaceae 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_853966_1 886293.Sinac_3925 8.8e-72 224.0 COG1208@1|root,COG1208@2|Bacteria,2IX9K@203682|Planctomycetes 203682|Planctomycetes JM Nucleotidyl transferase - - 2.7.7.33 ko:K00978 ko00500,ko00520,ko01100,map00500,map00520,map01100 - R00956 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_906402_1 395495.Lcho_4114 2.32e-62 204.0 COG3292@1|root,COG3292@2|Bacteria,1N0TN@1224|Proteobacteria,2VMZM@28216|Betaproteobacteria,1KNDQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Two component regulator propeller - - - - - - - - - - - - Reg_prop k59_1375995_1 999141.GME_12162 3.19e-44 160.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMSH@1236|Gammaproteobacteria,1XIQF@135619|Oceanospirillales 135619|Oceanospirillales G Alpha amylase, catalytic region - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - Alpha-amylase,DUF3459,Malt_amylase_C k59_1527097_1 696369.KI912183_gene2277 8.89e-68 231.0 COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,260N4@186807|Peptococcaceae 186801|Clostridia C formate C-acetyltransferase glycine radical - - 2.3.1.54,4.3.99.4 ko:K00656,ko:K20038 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like k59_1165194_1 1122963.AUHB01000010_gene1609 3.95e-49 164.0 COG2020@1|root,COG2020@2|Bacteria,1RDC4@1224|Proteobacteria,2TUXA@28211|Alphaproteobacteria,370S7@31993|Methylocystaceae 28211|Alphaproteobacteria O Phospholipid methyltransferase - - - - - - - - - - - - PEMT k59_1165196_3 1493512.A0A0E3FB49_9CAUD 5.25e-12 68.2 4QH89@10239|Viruses,4QQRH@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_386037_1 754477.Q7C_2417 8.14e-09 56.6 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,45ZXN@72273|Thiotrichales 72273|Thiotrichales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_814822_1 338963.Pcar_2338 6.71e-73 229.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,42M99@68525|delta/epsilon subdivisions,2WJ2Q@28221|Deltaproteobacteria,43S6A@69541|Desulfuromonadales 28221|Deltaproteobacteria L Holliday junction DNA helicase ruvB C-terminus ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_83036_1 1565314.OA34_03140 3.77e-48 170.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2YMV0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans k59_232308_1 1331060.RLDS_01140 5.02e-18 77.4 2DVDD@1|root,32UZ7@2|Bacteria,1NGRW@1224|Proteobacteria,2UC61@28211|Alphaproteobacteria,2K7IU@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF2933) - - - - - - - - - - - - DUF2933 k59_498947_1 1085623.GNIT_2130 5.55e-14 70.9 COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,467AZ@72275|Alteromonadaceae 1236|Gammaproteobacteria S High frequency lysogenization protein HflD homolog hflD GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009898,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944,GO:0098552,GO:0098562 - ko:K07153 - - - - ko00000 - - - DUF489 k59_498947_2 1110502.TMO_3061 2.35e-20 91.3 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,2JQQN@204441|Rhodospirillales 204441|Rhodospirillales C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_859629_1 298655.KI912266_gene2744 1.01e-118 351.0 COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria,4EU8E@85013|Frankiales 201174|Actinobacteria I Thiolase, C-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_859629_2 1121430.JMLG01000003_gene507 2.43e-09 57.4 COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1UDNN@1239|Firmicutes,24DF4@186801|Clostridia,263HP@186807|Peptococcaceae 186801|Clostridia I DUF35 OB-fold domain, acyl-CoA-associated - - 2.3.3.10 ko:K01641 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130 M00088,M00095 R01978 RC00004,RC00503 ko00000,ko00001,ko00002,ko01000 - - - ACP_syn_III_C,DUF35_N,OB_aCoA_assoc k59_176446_1 330214.NIDE4041 6.63e-75 225.0 COG1592@1|root,COG1592@2|Bacteria,3J0RY@40117|Nitrospirae 40117|Nitrospirae C Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_391317_1 1209989.TepiRe1_1235 1.2e-46 172.0 COG0768@1|root,COG2815@1|root,COG0768@2|Bacteria,COG2815@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,42FD0@68295|Thermoanaerobacterales 186801|Clostridia M TIGRFAM stage V sporulation protein D spoVD - 3.4.16.4 ko:K03587,ko:K08384 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase k59_1015899_1 216594.MMAR_3425 1.85e-70 231.0 COG1073@1|root,COG1073@2|Bacteria,2I8SP@201174|Actinobacteria,23AD2@1762|Mycobacteriaceae 201174|Actinobacteria S alpha beta - - - - - - - - - - - - - k59_1015899_2 686578.AFFX01000009_gene3042 0.000301 44.3 2ASE4@1|root,31HTP@2|Bacteria,1RHGP@1224|Proteobacteria,1S6BD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_83054_1 411483.FAEPRAA2165_02832 1.44e-16 76.3 COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,2496R@186801|Clostridia,3WIFT@541000|Ruminococcaceae 186801|Clostridia J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_83054_2 156889.Mmc1_0863 6.21e-32 116.0 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2U9A6@28211|Alphaproteobacteria 28211|Alphaproteobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_704528_1 1397528.Q671_14960 1.52e-39 145.0 COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,1S11R@1236|Gammaproteobacteria,1XS39@135619|Oceanospirillales 135619|Oceanospirillales L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_498977_1 1229909.NSED_09475 6.64e-75 237.0 COG0531@1|root,arCOG00009@2157|Archaea,41SXX@651137|Thaumarchaeota 651137|Thaumarchaeota E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_1325815_1 1469245.JFBG01000080_gene301 3.15e-55 179.0 COG3751@1|root,COG3751@2|Bacteria,1NAUK@1224|Proteobacteria 1224|Proteobacteria O Putative 2OG-Fe(II) oxygenase - - - - - - - - - - - - 2OG-FeII_Oxy_5 k59_1531282_2 502558.EGYY_09330 9.2e-05 50.4 COG3119@1|root,COG3119@2|Bacteria,2HUM0@201174|Actinobacteria,4CV35@84998|Coriobacteriia 84998|Coriobacteriia P arylsulfatase activity - - - - - - - - - - - - Sulfatase k59_754662_2 887929.HMP0721_1506 2e-10 59.7 COG0091@1|root,COG0091@2|Bacteria,1V6PU@1239|Firmicutes,24JF4@186801|Clostridia,25WWP@186806|Eubacteriaceae 186801|Clostridia J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_83069_1 322710.Avin_44920 1.97e-08 56.2 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC ctpF - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_83069_2 65093.PCC7418_1447 2.07e-30 119.0 COG3957@1|root,COG3957@2|Bacteria,1G0B2@1117|Cyanobacteria 1117|Cyanobacteria G D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase - - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_1532150_1 1535422.ND16A_0740 2.79e-69 223.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,2Q7EB@267889|Colwelliaceae 1236|Gammaproteobacteria P PFAM sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_84498_1 1292020.H483_0114470 4.16e-54 192.0 COG0439@1|root,COG4770@1|root,COG4799@1|root,COG0439@2|Bacteria,COG4770@2|Bacteria,COG4799@2|Bacteria,2GIZP@201174|Actinobacteria 201174|Actinobacteria I carboxylase - - - - - - - - - - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans k59_84498_2 649747.HMPREF0083_01467 0.000936 43.5 COG1028@1|root,COG1028@2|Bacteria,1VS53@1239|Firmicutes,4HTSQ@91061|Bacilli,274QU@186822|Paenibacillaceae 91061|Bacilli IQ KR domain - - 1.1.1.401 ko:K21883 ko00051,ko01120,map00051,map01120 - R11339 RC00089 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_1382069_2 395493.BegalDRAFT_2325 3.95e-54 188.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,45ZSQ@72273|Thiotrichales 72273|Thiotrichales S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_131553_1 690585.JNNU01000003_gene5550 7.9e-47 160.0 COG3917@1|root,COG3917@2|Bacteria,1MWB9@1224|Proteobacteria,2U07P@28211|Alphaproteobacteria,4BCUR@82115|Rhizobiaceae 28211|Alphaproteobacteria Q 2-hydroxychromene-2-carboxylate isomerase - - - - - - - - - - - - DSBA k59_131553_2 1101190.ARWB01000001_gene1706 3.16e-22 91.7 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,36Y14@31993|Methylocystaceae 28211|Alphaproteobacteria O Glutathione S-transferase, C-terminal domain gst7 - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_N,GST_N_3 k59_286466_1 330214.NIDE3441 1.05e-133 391.0 COG0305@1|root,COG0305@2|Bacteria,3J0EZ@40117|Nitrospirae 40117|Nitrospirae L Participates in initiation and elongation during chromosome replication - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_1591643_2 1086011.HJ01_03311 2.39e-52 169.0 COG0394@1|root,COG0394@2|Bacteria,4NNN6@976|Bacteroidetes,1I2XM@117743|Flavobacteriia,2NW88@237|Flavobacterium 976|Bacteroidetes T Belongs to the low molecular weight phosphotyrosine protein phosphatase family arsC - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_392189_1 498211.CJA_1825 2.51e-31 121.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,1FI6X@10|Cellvibrio 1236|Gammaproteobacteria C Multicopper oxidase pcoA - - - - - - - - - - - CopB,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_392189_2 1198232.CYCME_1364 3.91e-114 333.0 COG3667@1|root,COG3667@2|Bacteria,1MXW6@1224|Proteobacteria,1RZEY@1236|Gammaproteobacteria,460RF@72273|Thiotrichales 72273|Thiotrichales P Copper resistance protein B precursor (CopB) - - - ko:K07233 - - - - ko00000 - - - CopB k59_392189_3 331113.SNE_A22860 1.99e-26 107.0 COG1373@1|root,COG1373@2|Bacteria 2|Bacteria V ATPase (AAA superfamily - - - ko:K07133 - - - - ko00000 - - - AAA_14,DUF4143 k59_444298_1 1207063.P24_01956 5.65e-106 324.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2TQXH@28211|Alphaproteobacteria,2JQXD@204441|Rhodospirillales 204441|Rhodospirillales Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_1121878_1 1415780.JPOG01000001_gene1376 6.1e-84 258.0 COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,1T1N6@1236|Gammaproteobacteria,1X358@135614|Xanthomonadales 135614|Xanthomonadales CE Catalyzes the formation of 2-oxoglutarate from isocitrate - - 1.1.1.41 ko:K00030 ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00709 RC00114 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_1121878_2 1469245.JFBG01000091_gene1645 2.89e-82 254.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1WXNB@135613|Chromatiales 135613|Chromatiales BQ PFAM Histone deacetylase - - - - - - - - - - - - Hist_deacetyl k59_84528_1 1219375.CM002139_gene4072 3.25e-51 181.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1X486@135614|Xanthomonadales 135614|Xanthomonadales I 3-hydroxyacyl-coa dehydrogenase fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_131571_1 247634.GPB2148_96 5.26e-58 203.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria,1SMN0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_546390_1 1120983.KB894574_gene1102 2.28e-33 140.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,1JPZW@119043|Rhodobiaceae 28211|Alphaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_338705_1 331869.BAL199_24784 1.72e-19 85.9 COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2TRA8@28211|Alphaproteobacteria,4BPA8@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM coxM - 1.2.5.3 ko:K03519 - - R11168 RC02800 ko00000,ko01000 - - - CO_deh_flav_C,FAD_binding_5 k59_338705_2 1510531.JQJJ01000008_gene3399 9.27e-45 162.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3JR85@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain coxL - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_500450_1 1217718.ALOU01000007_gene1259 7.21e-59 194.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2VM5U@28216|Betaproteobacteria,1KF02@119060|Burkholderiaceae 28216|Betaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_444319_1 1040989.AWZU01000023_gene4896 1.56e-20 90.5 28JPA@1|root,2Z9FC@2|Bacteria,1PN1F@1224|Proteobacteria,2TSKX@28211|Alphaproteobacteria,3JT6R@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_816320_1 981223.AIED01000012_gene3741 1.56e-59 196.0 COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,1RQKK@1236|Gammaproteobacteria,3NIJ9@468|Moraxellaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF815) - - - ko:K06923 - - - - ko00000 - - - DUF815 k59_816320_2 1385517.N800_10295 5.09e-09 60.1 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1X4H6@135614|Xanthomonadales 135614|Xanthomonadales M gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1382101_1 240016.ABIZ01000001_gene1258 1.17e-59 201.0 COG2204@1|root,COG2204@2|Bacteria,46SDB@74201|Verrucomicrobia,2IU0F@203494|Verrucomicrobiae 203494|Verrucomicrobiae T Sigma-54 interaction domain - - - - - - - - - - - - Response_reg,Sigma54_activat k59_177338_1 330214.NIDE1304 5.14e-100 322.0 COG0086@1|root,COG0086@2|Bacteria,3J0BT@40117|Nitrospirae 40117|Nitrospirae K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_705584_1 635013.TherJR_0297 2.25e-52 174.0 COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,248SY@186801|Clostridia,26186@186807|Peptococcaceae 186801|Clostridia J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_1591685_2 436308.Nmar_1301 7.53e-71 219.0 COG1339@1|root,arCOG01904@2157|Archaea,41SG9@651137|Thaumarchaeota 651137|Thaumarchaeota H Domain of unknown function DUF120 - - 2.7.1.161 ko:K07732 ko00740,ko01100,map00740,map01100 - R08574 RC00002,RC00017 ko00000,ko00001,ko01000 - - - CTP-dep_RFKase k59_1493905_1 1499967.BAYZ01000184_gene4586 3.04e-134 399.0 COG1222@1|root,COG1222@2|Bacteria,2NQB9@2323|unclassified Bacteria 2|Bacteria O Proteasomal ATPase OB/ID domain arc GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369 - ko:K13527 ko03050,map03050 M00342 - - ko00000,ko00001,ko00002,ko03051 - - - AAA,Prot_ATP_ID_OB k59_233400_2 1237149.C900_01581 9.16e-82 251.0 COG0330@1|root,COG0330@2|Bacteria,4NFNB@976|Bacteroidetes,47MT6@768503|Cytophagia 976|Bacteroidetes O PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7 k59_705592_1 1279015.KB908457_gene2281 2.27e-18 82.8 COG0589@1|root,COG0589@2|Bacteria,1N7EK@1224|Proteobacteria,1SCRX@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp k59_705592_2 1121939.L861_02780 2.12e-16 77.0 COG1177@1|root,COG1177@2|Bacteria,1MUQD@1224|Proteobacteria,1RP1E@1236|Gammaproteobacteria,1XJ43@135619|Oceanospirillales 135619|Oceanospirillales E Binding-protein-dependent transport system inner membrane component - - - ko:K02053 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - BPD_transp_1 k59_1286415_1 105559.Nwat_0234 2.27e-121 353.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1WW5R@135613|Chromatiales 135613|Chromatiales M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_705600_1 68570.DC74_1835 9.01e-26 105.0 COG2141@1|root,COG2141@2|Bacteria,2GKP1@201174|Actinobacteria 201174|Actinobacteria C Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_705600_2 1396858.Q666_13350 4.01e-09 55.1 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,1S62N@1236|Gammaproteobacteria,467UW@72275|Alteromonadaceae 1236|Gammaproteobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_1170352_1 1288494.EBAPG3_21590 3.66e-94 295.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2VHHJ@28216|Betaproteobacteria,372VA@32003|Nitrosomonadales 28216|Betaproteobacteria O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_1121935_1 1205680.CAKO01000028_gene4643 2.54e-21 90.5 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2UA46@28211|Alphaproteobacteria,2JSUT@204441|Rhodospirillales 204441|Rhodospirillales U Biopolymer transport protein tolR - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_233414_2 767817.Desgi_2465 1.47e-46 157.0 COG0131@1|root,COG0131@2|Bacteria,1TRH7@1239|Firmicutes,247WC@186801|Clostridia,261MD@186807|Peptococcaceae 186801|Clostridia E PFAM Imidazoleglycerol-phosphate dehydratase hisB - 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD k59_659374_1 635013.TherJR_0724 1.3e-83 264.0 COG0351@1|root,COG0352@1|root,COG0351@2|Bacteria,COG0352@2|Bacteria,1TQ4A@1239|Firmicutes,2483H@186801|Clostridia,260UU@186807|Peptococcaceae 186801|Clostridia H TIGRFAM phosphomethylpyrimidine kinase thiD - 2.5.1.3,2.7.1.49,2.7.4.7 ko:K00941,ko:K14153 ko00730,ko01100,map00730,map01100 M00127 R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_546443_1 379066.GAU_2486 9.37e-52 166.0 COG0662@1|root,COG0662@2|Bacteria,1ZTKY@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Mannose-6-phosphate isomerase - - - - - - - - - - - - Cupin_2 k59_860890_1 82654.Pse7367_3306 3.93e-30 118.0 COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,1GQI2@1117|Cyanobacteria 1117|Cyanobacteria T HD domain - - - - - - - - - - - - HD_5 k59_860890_2 1123073.KB899243_gene475 4.79e-59 194.0 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1X4WV@135614|Xanthomonadales 135614|Xanthomonadales J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS k59_913304_1 1197906.CAJQ02000042_gene4062 1.8e-44 155.0 COG2271@1|root,COG2271@2|Bacteria,1NJTU@1224|Proteobacteria,2TUBJ@28211|Alphaproteobacteria,3JU19@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Major Facilitator Superfamily MA20_01130 - - - - - - - - - - - MFS_1 k59_913304_2 472759.Nhal_1484 8.11e-43 145.0 COG1853@1|root,COG1853@2|Bacteria,1MUPP@1224|Proteobacteria,1RR4T@1236|Gammaproteobacteria,1WYXT@135613|Chromatiales 135613|Chromatiales S PFAM flavin reductase - - - - - - - - - - - - Flavin_Reduct k59_1440215_1 1217718.ALOU01000112_gene4314 2.65e-124 373.0 COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,2WB1W@28216|Betaproteobacteria,1K4YH@119060|Burkholderiaceae 28216|Betaproteobacteria I LssY C-terminus - - - - - - - - - - - - LssY_C k59_286547_2 1123376.AUIU01000013_gene1818 2.11e-85 261.0 COG0473@1|root,COG0473@2|Bacteria,3J0JQ@40117|Nitrospirae 40117|Nitrospirae C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_1286451_1 155864.EDL933_3230 5.89e-17 83.2 COG0740@1|root,COG0740@2|Bacteria,1MUQ9@1224|Proteobacteria,1RRQA@1236|Gammaproteobacteria 1236|Gammaproteobacteria OU Belongs to the peptidase S14 family clpP_2 - - - - - - - - - - - CLP_protease,Mu-like_gpT k59_1017110_1 1120983.KB894570_gene1955 4.24e-86 268.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,1JN3Z@119043|Rhodobiaceae 28211|Alphaproteobacteria C Citrate synthase, C-terminal domain gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_1326782_2 472759.Nhal_3101 9.36e-92 288.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1RP2N@1236|Gammaproteobacteria,1WWIM@135613|Chromatiales 135613|Chromatiales G TIGRFAM malto-oligosyltrehalose trehalohydrolase - - 3.2.1.141 ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3459 k59_605797_1 1030157.AFMP01000009_gene3655 4.61e-80 249.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria,2K3PM@204457|Sphingomonadales 204457|Sphingomonadales I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1447360_1 1226994.AMZB01000084_gene338 2.99e-77 251.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1YF1J@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_1503909_1 530564.Psta_2678 1.34e-64 209.0 COG4992@1|root,COG4992@2|Bacteria,2IWTF@203682|Planctomycetes 203682|Planctomycetes E COG4992 Ornithine acetylornithine aminotransferase argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1505419_1 321327.CYA_2186 4.7e-146 424.0 COG0722@1|root,COG0722@2|Bacteria,1G35W@1117|Cyanobacteria,1GYEV@1129|Synechococcus 1117|Cyanobacteria E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) aroF - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_1658713_1 1366050.N234_36230 3.12e-31 112.0 COG0277@1|root,COG0277@2|Bacteria,1P3BK@1224|Proteobacteria,2W416@28216|Betaproteobacteria 28216|Betaproteobacteria C Berberine and berberine like - - - - - - - - - - - - BBE k59_1178077_1 1282876.BAOK01000001_gene3324 3.13e-43 158.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2TRNX@28211|Alphaproteobacteria 28211|Alphaproteobacteria E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_713926_1 765913.ThidrDRAFT_2533 1.27e-56 192.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1WWCN@135613|Chromatiales 135613|Chromatiales S Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - - - - - - - - - - - - Peptidase_M48,TPR_19 k59_923786_1 1232410.KI421418_gene2158 3e-50 181.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria,43UC5@69541|Desulfuromonadales 28221|Deltaproteobacteria NU Bacterial type II/III secretion system short domain gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_1024879_1 452637.Oter_3166 4.05e-18 83.6 28H52@1|root,2Z7HQ@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_1024879_2 1268068.PG5_45220 1.99e-11 66.2 COG4447@1|root,COG4447@2|Bacteria,1RCNG@1224|Proteobacteria,1S1N2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - PSII_BNR k59_512042_1 436308.Nmar_1144 4.07e-75 234.0 COG0785@1|root,arCOG02398@2157|Archaea 2157|Archaea O cytochrome c biogenesis protein - - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD k59_763478_2 396588.Tgr7_1594 2.54e-278 766.0 COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,1RMGK@1236|Gammaproteobacteria,1WWHA@135613|Chromatiales 135613|Chromatiales E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine - - 4.2.1.20 ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1505446_1 1353529.M899_1201 8.77e-16 78.2 COG0789@1|root,COG0789@2|Bacteria,1R2NF@1224|Proteobacteria,43AJU@68525|delta/epsilon subdivisions,2MUE0@213481|Bdellovibrionales,2X600@28221|Deltaproteobacteria 213481|Bdellovibrionales K helix_turn_helix, mercury resistance - - - ko:K22491 - - - - ko00000,ko03000 - - - B12-binding,MerR_1 k59_1297828_1 886293.Sinac_1076 1.26e-06 50.1 COG1187@1|root,COG1187@2|Bacteria,2IYUS@203682|Planctomycetes 203682|Planctomycetes J Belongs to the pseudouridine synthase RsuA family - - 5.4.99.20,5.4.99.22 ko:K06178,ko:K06181 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1297828_2 690850.Desaf_2895 3.26e-32 116.0 COG1993@1|root,COG1993@2|Bacteria,1N0EM@1224|Proteobacteria,42TZK@68525|delta/epsilon subdivisions,2WQ2E@28221|Deltaproteobacteria,2M86Z@213115|Desulfovibrionales 28221|Deltaproteobacteria T Uncharacterized ACR, COG1993 - - - ko:K09137 - - - - ko00000 - - - DUF190 k59_1132428_1 1283300.ATXB01000001_gene1335 7.8e-52 168.0 COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,1XE01@135618|Methylococcales 135618|Methylococcales L Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis rnt - - ko:K03683 - - - - ko00000,ko01000,ko03016 - - - RNase_T k59_1132428_2 237368.SCABRO_03545 8.4e-25 98.2 COG2138@1|root,COG2138@2|Bacteria,2J082@203682|Planctomycetes 203682|Planctomycetes H Cobalamin (Vitamin B12) biosynthesis CbiX protein - - - - - - - - - - - - CbiX k59_1132428_3 243233.MCA1273 6.94e-15 74.7 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1XEMS@135618|Methylococcales 135618|Methylococcales F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_454644_1 1380394.JADL01000011_gene4003 2.09e-11 64.7 2E1AA@1|root,32WQB@2|Bacteria,1N6IG@1224|Proteobacteria,2UDF7@28211|Alphaproteobacteria,2JU5V@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_454644_2 1110502.TMO_1599 5.75e-72 224.0 28NA5@1|root,2ZBDZ@2|Bacteria,1MXY5@1224|Proteobacteria,2TYZX@28211|Alphaproteobacteria,2JWJ4@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_713945_1 1163409.UUA_08346 3.57e-68 229.0 COG0823@1|root,COG0823@2|Bacteria,1MWYK@1224|Proteobacteria,1RXYW@1236|Gammaproteobacteria,1XD03@135614|Xanthomonadales 135614|Xanthomonadales U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 k59_1448330_1 330214.NIDE4314 4.95e-57 188.0 COG1899@1|root,COG1899@2|Bacteria 2|Bacteria O peptidyl-lysine modification to peptidyl-hypusine - - - - - - - - - - - - - k59_184690_1 1380394.JADL01000014_gene127 1.51e-66 219.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2TSQI@28211|Alphaproteobacteria,2JPPT@204441|Rhodospirillales 204441|Rhodospirillales E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_296750_1 1313172.YM304_17130 0.000124 44.3 COG1028@1|root,COG1028@2|Bacteria,2GNM4@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_296750_2 205918.Psyr_3054 4.55e-07 52.4 COG0510@1|root,COG0510@2|Bacteria,1N77Z@1224|Proteobacteria,1SF9H@1236|Gammaproteobacteria,1Z8M7@136849|Pseudomonas syringae group 1236|Gammaproteobacteria M Choline/ethanolamine kinase licA - - - - - - - - - - - APH,Choline_kinase,F-box k59_923844_1 187272.Mlg_2442 2.6e-70 234.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_923851_1 574087.Acear_1651 7.13e-09 56.2 COG1220@1|root,COG1220@2|Bacteria,1TPKQ@1239|Firmicutes,2495P@186801|Clostridia,3WA74@53433|Halanaerobiales 186801|Clostridia O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_348907_1 1132855.KB913035_gene1892 2.79e-65 213.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2VHCR@28216|Betaproteobacteria,2KKWV@206350|Nitrosomonadales 206350|Nitrosomonadales S Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase k59_95443_2 926560.KE387023_gene2065 2.1e-20 90.9 COG1217@1|root,COG1217@2|Bacteria,1WINQ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_554837_1 1336208.JADY01000018_gene3216 1.87e-134 402.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TUKZ@28211|Alphaproteobacteria,2JW8Z@204441|Rhodospirillales 204441|Rhodospirillales J Amidase - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_828080_1 880074.BARVI_06635 7.07e-22 94.4 COG0703@1|root,COG0703@2|Bacteria,4NQ73@976|Bacteroidetes,2FM3K@200643|Bacteroidia,22Y40@171551|Porphyromonadaceae 976|Bacteroidetes F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_1505508_1 1122164.JHWF01000022_gene1721 5.54e-24 100.0 COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,1SASJ@1236|Gammaproteobacteria,1JDI7@118969|Legionellales 118969|Legionellales S Smr domain - - - - - - - - - - - - Smr k59_972518_1 1123400.KB904780_gene1764 3.15e-142 411.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,4604F@72273|Thiotrichales 72273|Thiotrichales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_512112_1 558884.JRGM01000149_gene3601 1.09e-26 103.0 COG1285@1|root,COG1285@2|Bacteria,1MURJ@1224|Proteobacteria,1S78Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria S MgtC family - - - ko:K07507 - - - - ko00000,ko02000 9.B.20 - - MgtC k59_1178136_2 1229909.NSED_09030 7.71e-88 264.0 COG2897@1|root,arCOG02019@2157|Archaea,41SXR@651137|Thaumarchaeota 651137|Thaumarchaeota P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_828092_1 1229909.NSED_00425 1.06e-07 59.3 COG0642@1|root,arCOG02358@2157|Archaea 2157|Archaea T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k59_1297912_2 1121441.AUCX01000006_gene918 1.46e-26 104.0 COG1664@1|root,COG1664@2|Bacteria,1N7TF@1224|Proteobacteria,42VWZ@68525|delta/epsilon subdivisions,2WRPF@28221|Deltaproteobacteria,2MBWU@213115|Desulfovibrionales 28221|Deltaproteobacteria M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin k59_95477_1 1197906.CAJQ02000015_gene308 1.65e-37 138.0 COG0346@1|root,COG0346@2|Bacteria,1R9XW@1224|Proteobacteria,2U6IT@28211|Alphaproteobacteria,3K3B6@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E lactoylglutathione lyase activity - - - - - - - - - - - - Glyoxalase_4 k59_1178144_2 269799.Gmet_2900 1.57e-34 129.0 COG0755@1|root,COG0755@2|Bacteria,1RG0A@1224|Proteobacteria,42N37@68525|delta/epsilon subdivisions,2WIKV@28221|Deltaproteobacteria,43W41@69541|Desulfuromonadales 28221|Deltaproteobacteria O Cytochrome C assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_554859_1 485913.Krac_5130 3.07e-31 124.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_399776_2 935863.AWZR01000002_gene1156 2.41e-44 149.0 COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,1S68X@1236|Gammaproteobacteria,1X5XQ@135614|Xanthomonadales 135614|Xanthomonadales S EVE domain-containing protein - - - - - - - - - - - - EVE k59_1297922_1 63405.XP_002848349.1 5.61e-18 82.8 COG3791@1|root,2SV9S@2759|Eukaryota,3A9Q3@33154|Opisthokonta,3P7EM@4751|Fungi,3QYAR@4890|Ascomycota,20IBH@147545|Eurotiomycetes,3B5N9@33183|Onygenales,3FW7E@34384|Arthrodermataceae 4751|Fungi S Glutathione-dependent formaldehyde-activating - - - - - - - - - - - - GFA k59_1297922_2 983545.Glaag_2406 1.96e-70 215.0 COG3631@1|root,COG3631@2|Bacteria,1RISB@1224|Proteobacteria,1SDAH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Ketosteroid isomerase-related protein - - - - - - - - - - - - - k59_1448366_1 765914.ThisiDRAFT_1911 2.23e-27 105.0 COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,1WYH2@135613|Chromatiales 135613|Chromatiales M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins - - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD k59_1448366_2 1214065.BAGV01000062_gene1081 9.65e-07 53.5 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,282PU@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria M Involved in formation and maintenance of cell shape mreC GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0043621,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944,GO:0071963 - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_512142_3 443218.AS9A_0266 6.43e-06 50.4 COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,235SN@1762|Mycobacteriaceae 201174|Actinobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases glxR GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_763550_1 84531.JMTZ01000030_gene214 2.77e-72 237.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1X2Z8@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_763550_2 472759.Nhal_3683 7.08e-60 194.0 COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,1WZWK@135613|Chromatiales 135613|Chromatiales G pfkB family carbohydrate kinase - - 2.7.1.20 ko:K00856 ko00230,ko01100,map00230,map01100 - R00185 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_1132533_1 1283300.ATXB01000001_gene1708 6e-72 238.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1XEPA@135618|Methylococcales 1236|Gammaproteobacteria O Belongs to the peptidase S16 family - - - ko:K04770 - - - - ko00000,ko01000,ko01002 - - - AAA_32,Lon_C k59_95513_1 1144275.COCOR_02280 9.23e-38 140.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WJQQ@28221|Deltaproteobacteria,2YU8H@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_95513_2 1121926.AXWO01000001_gene3737 0.000962 42.7 COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4EXWU@85014|Glycomycetales 201174|Actinobacteria I Methylmalonyl-CoA mutase icmA - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_923926_1 290397.Adeh_0121 2.43e-104 311.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,42MI2@68525|delta/epsilon subdivisions,2WJ5W@28221|Deltaproteobacteria,2YUB9@29|Myxococcales 28221|Deltaproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2848 Pribosyl_synth,Pribosyltran_N k59_1178164_1 566466.NOR53_3091 5.56e-28 117.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,1RNCM@1236|Gammaproteobacteria,1J866@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_714036_1 1049564.TevJSym_ao00280 1.51e-69 235.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1224|Proteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1658873_1 1167006.UWK_01277 9.44e-10 59.7 COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria,2MHU3@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_4,PAS_9 k59_1658873_2 247490.KSU1_B0365 1.08e-25 109.0 COG2204@1|root,COG2204@2|Bacteria,2IXIQ@203682|Planctomycetes 203682|Planctomycetes T Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_763569_1 330214.NIDE1236 5.21e-53 175.0 COG0501@1|root,COG0501@2|Bacteria,3J0QG@40117|Nitrospirae 40117|Nitrospirae O Peptidase family M48 htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_296862_2 671143.DAMO_2687 5.05e-25 96.3 COG2161@1|root,COG2161@2|Bacteria 2|Bacteria D toxin-antitoxin pair type II binding relF GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097351,GO:1903506,GO:2000112,GO:2001141 2.3.1.15 ko:K08591,ko:K19159 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004,ko02048 - - - PhdYeFM_antitox k59_141651_1 1288494.EBAPG3_330 7.71e-100 302.0 COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,2VJMX@28216|Betaproteobacteria,3724U@32003|Nitrosomonadales 28216|Betaproteobacteria O Uncharacterized protein family (UPF0051) sufB - - ko:K09014 - - - - ko00000 - - - UPF0051 k59_512187_1 1122194.AUHU01000002_gene2490 1.62e-12 67.8 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,465ZV@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase rarA GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_252348_1 283942.IL0591 5.64e-87 285.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,2QF18@267893|Idiomarinaceae 1236|Gammaproteobacteria F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080 AIRS_C,GATase_5 k59_1399409_1 395494.Galf_0861 2.15e-41 139.0 COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,2VTC8@28216|Betaproteobacteria,44WK9@713636|Nitrosomonadales 28216|Betaproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_1399409_2 394221.Mmar10_1457 1.02e-10 61.6 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,2TWZ1@28211|Alphaproteobacteria,44159@69657|Hyphomonadaceae 28211|Alphaproteobacteria K cAMP biosynthetic process - - - - - - - - - - - - Guanylate_cyc,Trans_reg_C k59_1457960_1 330214.NIDE3045 3.51e-82 251.0 COG1210@1|root,COG1210@2|Bacteria,3J0B2@40117|Nitrospirae 40117|Nitrospirae M Nucleotidyl transferase galU - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_1035294_1 1265313.HRUBRA_02672 2.87e-19 86.7 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1J4C0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Participates in both transcription termination and antitermination nusA GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_1035294_2 666685.R2APBS1_1476 8.3e-20 90.1 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1X4G8@135614|Xanthomonadales 135614|Xanthomonadales J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_1343959_1 1112217.PPL19_12773 2.04e-06 50.8 COG4970@1|root,COG4970@2|Bacteria,1NGHS@1224|Proteobacteria 1224|Proteobacteria NU COG4970 Tfp pilus assembly protein FimT fimT - - ko:K08084,ko:K08085 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_359693_1 1523503.JPMY01000045_gene71 1.25e-30 114.0 28H8Z@1|root,2Z7KS@2|Bacteria,1MW9T@1224|Proteobacteria,1RQV1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane yohC GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944 - - - - - - - - - - DUF1282 k59_359693_2 1348657.M622_12350 8.9e-24 101.0 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,2VJSM@28216|Betaproteobacteria,2KV1V@206389|Rhodocyclales 206389|Rhodocyclales P cation transport ATPase ccoI - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_617790_1 1244869.H261_06399 1.06e-14 76.3 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2TR86@28211|Alphaproteobacteria,2JPJU@204441|Rhodospirillales 204441|Rhodospirillales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_617790_2 331113.SNE_A09700 3.35e-24 94.0 COG2154@1|root,COG2154@2|Bacteria,2JGH7@204428|Chlamydiae 204428|Chlamydiae H Pterin 4 alpha carbinolamine dehydratase - - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a k59_981448_1 395493.BegalDRAFT_2429 1.17e-71 223.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,4604S@72273|Thiotrichales 72273|Thiotrichales J glycyl-tRNA synthetase, alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_410804_1 1229909.NSED_02770 1.61e-99 297.0 COG0082@1|root,arCOG04133@2157|Archaea,41SC3@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_773518_1 566461.SSFG_05171 1.43e-54 185.0 COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria 201174|Actinobacteria S epimerase - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase k59_878900_1 76114.ebA4666 6.58e-97 301.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2VKAN@28216|Betaproteobacteria,2KVQH@206389|Rhodocyclales 206389|Rhodocyclales I Acetyl-coenzyme A synthetase N-terminus - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_724457_1 444860.E3SJ44_9CAUD 3.77e-105 327.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QHVQ@10662|Myoviridae 10662|Myoviridae S nucleotide binding - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016032,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019058,GO:0019079,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0039686,GO:0039693,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044403,GO:0044419,GO:0046483,GO:0051704,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_410840_1 330214.NIDE0325 3.13e-95 291.0 COG1236@1|root,COG1236@2|Bacteria,3J0FD@40117|Nitrospirae 40117|Nitrospirae J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_1144254_1 1121124.JNIX01000007_gene587 6.06e-14 72.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,2KFS4@204458|Caulobacterales 204458|Caulobacterales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1144254_2 634177.GLX_08800 1.15e-60 201.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2TS3R@28211|Alphaproteobacteria,2JQFG@204441|Rhodospirillales 204441|Rhodospirillales O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_981500_1 684719.HIMB114_00013370 1.41e-24 102.0 COG0265@1|root,COG0265@2|Bacteria,1MURF@1224|Proteobacteria,2TUVW@28211|Alphaproteobacteria,4BS24@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O Trypsin-like peptidase domain - - - - - - - - - - - - PDZ_2,Trypsin_2 k59_1344030_1 1382356.JQMP01000004_gene563 1.28e-74 239.0 COG1012@1|root,COG1012@2|Bacteria,2G5JE@200795|Chloroflexi,27XTS@189775|Thermomicrobia 200795|Chloroflexi C Aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128,ko:K00138 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00711,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1091504_1 579137.Metvu_0074 1.12e-17 84.3 COG0859@1|root,arCOG09554@2157|Archaea,2Y3GR@28890|Euryarchaeota,23RKF@183939|Methanococci 183939|Methanococci M PFAM glycosyl transferase family 9 - - - ko:K02843,ko:K02849 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_1091504_2 1232437.KL662006_gene4458 5.57e-68 219.0 COG0381@1|root,COG0381@2|Bacteria,1MWZN@1224|Proteobacteria,43B4D@68525|delta/epsilon subdivisions,2WKC8@28221|Deltaproteobacteria,2MJQU@213118|Desulfobacterales 28221|Deltaproteobacteria M UDP-N-acetylglucosamine 2-epimerase - - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_1344033_1 518766.Rmar_1654 1.12e-53 175.0 COG1628@1|root,COG1628@2|Bacteria 2|Bacteria S Protein of unknown function DUF99 - - - ko:K09120 - - - - ko00000 - - - DUF99 k59_1187790_1 1206737.BAGF01000042_gene2640 1.54e-86 263.0 COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4FU0S@85025|Nocardiaceae 201174|Actinobacteria C Luciferase-like monooxygenase - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Bac_luciferase k59_359752_1 1049564.TevJSym_ad00760 3.69e-63 202.0 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1J4S7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K00795,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_465343_1 1121441.AUCX01000012_gene3287 9.34e-52 183.0 COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WIX6@28221|Deltaproteobacteria,2M9D1@213115|Desulfovibrionales 28221|Deltaproteobacteria C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,POR_N,TPP_enzyme_C k59_617868_1 314278.NB231_05606 1.21e-60 202.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1WWI1@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_1607079_1 1589733.A0A0C5AIT8_9CAUD 4.98e-23 95.9 4QAQQ@10239|Viruses,4QPBX@28883|Caudovirales,4QIBM@10662|Myoviridae 10662|Myoviridae S T4-like virus tail tube protein gp19 - - - - - - - - - - - - - k59_359767_1 1380391.JIAS01000017_gene624 2.56e-72 232.0 COG0665@1|root,COG0665@2|Bacteria,1MXD1@1224|Proteobacteria,2TTDG@28211|Alphaproteobacteria,2JQZU@204441|Rhodospirillales 204441|Rhodospirillales E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_359767_2 331869.BAL199_21564 4.41e-24 97.1 COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,2TU60@28211|Alphaproteobacteria,4BS1Y@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria F Glutamine amidotransferase class-I guaA2 - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase k59_773570_2 1286106.MPL1_08072 3.62e-117 349.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,46066@72273|Thiotrichales 72273|Thiotrichales F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily - - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_981542_1 1397666.RS24_01942 2.45e-83 258.0 COG1028@1|root,COG1028@2|Bacteria,1NAZS@1224|Proteobacteria,2U2UF@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_359777_1 653733.Selin_0324 1.89e-64 203.0 COG2128@1|root,COG2128@2|Bacteria 2|Bacteria S hydroperoxide reductase activity ynjA - - ko:K07486 - - - - ko00000 - - - CMD k59_307857_1 866895.HBHAL_3775 3.28e-06 56.2 COG4262@1|root,COG4262@2|Bacteria,1UHSI@1239|Firmicutes,4HAWQ@91061|Bacilli,3ND9X@45667|Halobacillus 91061|Bacilli S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_1035388_1 886293.Sinac_0383 2.55e-64 213.0 COG0475@1|root,COG0475@2|Bacteria,2IZ8F@203682|Planctomycetes 203682|Planctomycetes P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_1550489_2 1168065.DOK_15993 2.11e-07 54.3 COG0457@1|root,COG0457@2|Bacteria,1MVCA@1224|Proteobacteria,1RS02@1236|Gammaproteobacteria,1J575@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - ANAPC3,TPR_16,TPR_8 k59_1458094_1 1442599.JAAN01000036_gene531 9.64e-72 235.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1X3HM@135614|Xanthomonadales 135614|Xanthomonadales O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_1399558_1 880072.Desac_2527 4.78e-55 181.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,42QV4@68525|delta/epsilon subdivisions,2WMR6@28221|Deltaproteobacteria,2MQE6@213462|Syntrophobacterales 28221|Deltaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_1091559_1 1232410.KI421421_gene3663 2.27e-28 117.0 COG1192@1|root,COG1192@2|Bacteria,1NPCB@1224|Proteobacteria,42Y7J@68525|delta/epsilon subdivisions,2WUHN@28221|Deltaproteobacteria,43T7Q@69541|Desulfuromonadales 28221|Deltaproteobacteria D NUBPL iron-transfer P-loop NTPase - - - - - - - - - - - - AAA_31 k59_1035397_1 316067.Geob_2763 1.25e-47 174.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,43SYQ@69541|Desulfuromonadales 28221|Deltaproteobacteria H Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 k59_1550504_1 1122176.KB903548_gene1200 1.7e-09 65.1 COG2936@1|root,COG2936@2|Bacteria,4P0KE@976|Bacteroidetes 976|Bacteroidetes S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - - - - - - - - - - PepX_C,Peptidase_S15 k59_1091566_1 1173024.KI912148_gene4487 4.28e-39 144.0 COG0438@1|root,COG0438@2|Bacteria,1GJ57@1117|Cyanobacteria,1JHMN@1189|Stigonemataceae 1117|Cyanobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_565345_1 296591.Bpro_4153 8.3e-38 137.0 COG3917@1|root,COG3917@2|Bacteria,1RJFB@1224|Proteobacteria,2VPYN@28216|Betaproteobacteria,4ACDE@80864|Comamonadaceae 28216|Betaproteobacteria Q 2-hydroxychromene-2-carboxylate isomerase - - - - - - - - - - - - DSBA k59_1092869_1 1123377.AUIV01000005_gene1740 4.76e-79 250.0 COG2010@1|root,COG2132@1|root,COG2010@2|Bacteria,COG2132@2|Bacteria,1MV74@1224|Proteobacteria,1RXZF@1236|Gammaproteobacteria,1X3IK@135614|Xanthomonadales 135614|Xanthomonadales CQ Multicopper oxidase - - 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Cu-oxidase,Cu-oxidase_3,Cytochrome_CBB3 k59_1345482_1 472759.Nhal_3357 4.9e-81 252.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1WXK2@135613|Chromatiales 135613|Chromatiales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1400896_1 211165.AJLN01000051_gene4893 6.86e-18 81.6 COG1335@1|root,COG1335@2|Bacteria,1G10P@1117|Cyanobacteria,1JHM2@1189|Stigonemataceae 1117|Cyanobacteria Q isochorismatase - - - - - - - - - - - - - k59_1400896_2 243233.MCA1213 5.36e-56 190.0 COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,1SZW9@1236|Gammaproteobacteria,1XFPE@135618|Methylococcales 135618|Methylococcales L DNA polymerase X family - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP k59_1459475_2 999411.HMPREF1092_03060 5.09e-08 56.6 COG4778@1|root,COG4778@2|Bacteria,1TS10@1239|Firmicutes,24C2T@186801|Clostridia,36ET2@31979|Clostridiaceae 186801|Clostridia P ATPases associated with a variety of cellular activities phnL - 2.7.8.37 ko:K05780 ko00440,map00440 - R10185 RC00005,RC00063 ko00000,ko00001,ko01000 - - - ABC_tran k59_1145994_1 882083.SacmaDRAFT_2247 9.27e-38 137.0 COG1545@1|root,COG1545@2|Bacteria,2GJHW@201174|Actinobacteria,4E22I@85010|Pseudonocardiales 201174|Actinobacteria I Rubredoxin-like zinc ribbon domain (DUF35_N) - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_1145994_2 1123279.ATUS01000001_gene1113 1.93e-54 181.0 COG1545@1|root,COG1545@2|Bacteria,1RANG@1224|Proteobacteria,1S32D@1236|Gammaproteobacteria,1J5UU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S nucleic-acid-binding protein containing a Zn-ribbon - - - - - - - - - - - - DUF35_N,OB_aCoA_assoc k59_1145994_3 1236902.ANAS01000022_gene113 4.56e-17 81.3 COG0183@1|root,COG0183@2|Bacteria,2GNCM@201174|Actinobacteria,4EGCV@85012|Streptosporangiales 201174|Actinobacteria I lipid-transfer protein - - - - - - - - - - - - Thiolase_C k59_1189277_1 1120999.JONM01000001_gene1500 2.85e-08 58.9 COG3637@1|root,COG3637@2|Bacteria,1N7U7@1224|Proteobacteria,2VRRF@28216|Betaproteobacteria,2KTSV@206351|Neisseriales 206351|Neisseriales M OmpA-like transmembrane domain - - - - - - - - - - - - OmpA_membrane k59_1400906_1 1246448.ANAZ01000054_gene1214 3.31e-14 79.0 COG0847@1|root,COG0847@2|Bacteria,2GJZ0@201174|Actinobacteria 201174|Actinobacteria L DNA polymerase III - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DUF2510,Lsr2,RNase_T k59_566514_1 1589733.A0A0C5AAX2_9CAUD 5.63e-09 62.4 4QEE7@10239|Viruses,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae 10662|Myoviridae S Pfam:DUF4815 - - - - - - - - - - - - - k59_1252492_1 1254432.SCE1572_31550 8.44e-30 120.0 COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,437UX@68525|delta/epsilon subdivisions,2X34D@28221|Deltaproteobacteria,2YU7H@29|Myxococcales 28221|Deltaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_21262_1 396588.Tgr7_0007 6.29e-93 278.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1WWV1@135613|Chromatiales 135613|Chromatiales L PFAM Endonuclease Exonuclease phosphatase - - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_566526_1 1049564.TevJSym_ag00080 3.06e-85 263.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,1J5A4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B k59_619443_1 572477.Alvin_0416 1.55e-51 165.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria,1WYPB@135613|Chromatiales 135613|Chromatiales FG PFAM Histidine triad (HIT) protein - - - ko:K02503 - - - - ko00000,ko04147 - - - DcpS_C,HIT k59_936448_1 1504822.CCNO01000015_gene947 4.9e-57 187.0 COG0052@1|root,COG0052@2|Bacteria,2NP4M@2323|unclassified Bacteria 2|Bacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_197407_1 880071.Fleli_1480 2.6e-06 55.1 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,4NKPG@976|Bacteroidetes,47TCB@768503|Cytophagia 976|Bacteroidetes L Winged helix-turn helix - - - - - - - - - - - - DDE_3,HTH_29,HTH_33 k59_1608204_1 448385.sce0969 3.26e-37 142.0 COG1409@1|root,COG1409@2|Bacteria,1R0BM@1224|Proteobacteria,43CTY@68525|delta/epsilon subdivisions,2X81I@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - - - - - - - - - - - k59_1189321_1 28042.GU90_17660 1.31e-34 130.0 COG1191@1|root,COG1191@2|Bacteria,2GKBK@201174|Actinobacteria,4DZK1@85010|Pseudonocardiales 201174|Actinobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released whiG - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_197419_1 316067.Geob_0465 2.2e-68 221.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00333,ko:K13378,ko:K13380 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases k59_1252527_1 1160137.KB907308_gene6437 4.14e-56 189.0 COG5285@1|root,COG5285@2|Bacteria,2IC8K@201174|Actinobacteria 201174|Actinobacteria Q Phytanoyl-CoA dioxygenase (PhyH) - - - - - - - - - - - - PhyH k59_1400962_1 1206739.BAGJ01000127_gene1442 1.85e-36 135.0 COG0240@1|root,COG0240@2|Bacteria,2GJSD@201174|Actinobacteria,4FUPH@85025|Nocardiaceae 201174|Actinobacteria C Glycerol-3-phosphate dehydrogenase gpsA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_619487_1 439235.Dalk_1804 2.43e-15 80.9 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,42NG6@68525|delta/epsilon subdivisions,2WIRU@28221|Deltaproteobacteria,2MK6C@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - Spermine_synth k59_1400984_1 661367.LLO_3332 4.61e-30 121.0 COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,1RRIA@1236|Gammaproteobacteria,1JCNG@118969|Legionellales 118969|Legionellales E 7 transmembrane helices usually fused to an inactive transglutaminase - - - - - - - - - - - - 7TM_transglut,Transglut_i_TM k59_1400984_2 102125.Xen7305DRAFT_00007800 4.27e-06 48.1 COG4067@1|root,COG4067@2|Bacteria,1G6KI@1117|Cyanobacteria,3VJXQ@52604|Pleurocapsales 1117|Cyanobacteria O Putative ATP-dependant zinc protease - - - - - - - - - - - - Zn_protease k59_361203_1 1229909.NSED_01335 1.54e-100 297.0 COG0142@1|root,arCOG01727@2157|Archaea,41SC6@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the FPP GGPP synthase family - - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_732817_1 933262.AXAM01000027_gene2113 2.99e-11 68.2 COG1716@1|root,COG2304@1|root,COG1716@2|Bacteria,COG2304@2|Bacteria 2|Bacteria IU oxidoreductase activity - - - ko:K08777 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002 - - - FHA,VWA k59_1620807_1 519989.ECTPHS_10696 3.39e-67 211.0 COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1WX5A@135613|Chromatiales 135613|Chromatiales U PFAM MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_837267_1 1131814.JAFO01000001_gene2366 1.43e-13 75.5 COG0658@1|root,COG0658@2|Bacteria,1MUKF@1224|Proteobacteria,2TRD5@28211|Alphaproteobacteria,3EYM5@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Domain of unknown function (DUF4131) - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131 k59_210392_2 273068.TTE2389 3.35e-167 484.0 COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,42FIA@68295|Thermoanaerobacterales 186801|Clostridia I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01847,ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_680825_2 1128421.JAGA01000003_gene2824 1.45e-08 55.1 COG1488@1|root,COG1488@2|Bacteria,2NNUE@2323|unclassified Bacteria 2|Bacteria H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP pncB GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - iYO844.BSU31750 NAPRTase k59_1620817_1 1161902.HMPREF0378_1150 2.29e-16 73.9 COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,24JCS@186801|Clostridia,3WCK3@538999|Clostridiales incertae sedis 186801|Clostridia J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_1620817_2 243231.GSU2840 5.11e-59 186.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,43U7V@69541|Desulfuromonadales 28221|Deltaproteobacteria J Belongs to the universal ribosomal protein uS5 family rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_105651_2 1382359.JIAL01000001_gene1494 6.67e-26 104.0 COG1028@1|root,COG1028@2|Bacteria,3Y2YB@57723|Acidobacteria,2JKGN@204432|Acidobacteriia 204432|Acidobacteriia IQ NAD dependent epimerase/dehydratase family - - - - - - - - - - - - adh_short_C2 k59_1150491_1 756272.Plabr_3756 6.78e-79 251.0 COG4146@1|root,COG4146@2|Bacteria,2J1R6@203682|Planctomycetes 203682|Planctomycetes S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1359690_1 489825.LYNGBM3L_21190 1.25e-39 143.0 COG0438@1|root,COG0438@2|Bacteria,1GC2Y@1117|Cyanobacteria 1117|Cyanobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - k59_837280_1 1232437.KL662016_gene1047 2.11e-69 211.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria 1224|Proteobacteria EQ N-methylhydantoinase B acetone carboxylase alpha subunit MA20_04180 - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_1307121_1 436114.SYO3AOP1_1494 1.56e-14 80.1 COG0258@1|root,COG0258@2|Bacteria,2G3XK@200783|Aquificae 200783|Aquificae L 5'-3' exonuclease - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A k59_680841_2 1415778.JQMM01000001_gene2181 9.1e-51 176.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1J5DU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA1 - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_523844_1 207954.MED92_15303 2.63e-35 125.0 COG3495@1|root,COG3495@2|Bacteria,1RB8H@1224|Proteobacteria,1S9ZC@1236|Gammaproteobacteria,1XK6A@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - ko:K09950 - - - - ko00000 - - - DUF3299 k59_1411581_2 1499686.BN1079_00114 2.06e-48 164.0 COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Hydrolase gph - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_837283_1 472759.Nhal_0689 1.77e-105 311.0 COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1WWC1@135613|Chromatiales 135613|Chromatiales O TIGRFAM FeS assembly ATPase SufC - - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_837283_2 388051.AUFE01000065_gene3874 4.36e-12 67.0 COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2VMJ9@28216|Betaproteobacteria,1K26K@119060|Burkholderiaceae 28216|Betaproteobacteria O Uncharacterized protein family (UPF0051) sufD - - ko:K09015 - - - - ko00000 - - - UPF0051 k59_732853_1 1131266.ARWQ01000010_gene41 1.05e-14 70.5 COG0197@1|root,arCOG04113@2157|Archaea,41SKN@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein - - - ko:K02866 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_732853_2 436308.Nmar_0448 4.36e-37 126.0 arCOG10525@1|root,arCOG10525@2157|Archaea,41SUR@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1620839_2 1123519.PSJM300_15235 1.35e-10 62.4 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1Z1MF@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria F Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004652,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006276,GO:0006378,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0031124,GO:0034641,GO:0043170,GO:0043412,GO:0043631,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_1046197_3 5691.EAN79296 9.78e-18 92.4 COG0749@1|root,KOG0950@2759|Eukaryota,3XTEJ@5653|Kinetoplastida 5653|Kinetoplastida L mitochondrial DNA polymerase I protein D - - - - - - - - - - - - DNA_pol_A,DNA_pol_A_exo1 k59_1203206_1 521045.Kole_0011 1.17e-60 209.0 COG0060@1|root,COG0060@2|Bacteria,2GC5I@200918|Thermotogae 200918|Thermotogae J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_837300_1 1318628.MARLIPOL_02290 1.3e-33 129.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,464MW@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_993621_1 1260251.SPISAL_08215 1.13e-75 239.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1WW22@135613|Chromatiales 135613|Chromatiales K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_210432_1 1469245.JFBG01000074_gene99 1.7e-117 345.0 COG0482@1|root,COG0482@2|Bacteria,1QV6H@1224|Proteobacteria,1RQSV@1236|Gammaproteobacteria 1236|Gammaproteobacteria J tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain - - - - - - - - - - - - ThiI,tRNA_Me_trans k59_157736_1 28583.AMAG_04793T0 2.54e-42 160.0 COG1194@1|root,KOG2457@2759|Eukaryota,38HVJ@33154|Opisthokonta,3NX1P@4751|Fungi 4751|Fungi L a g-specific adenine - GO:0000075,GO:0000077,GO:0000700,GO:0000701,GO:0000702,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006298,GO:0006304,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008534,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009893,GO:0009987,GO:0010604,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0019219,GO:0019222,GO:0030983,GO:0031323,GO:0031325,GO:0031570,GO:0032069,GO:0032075,GO:0032356,GO:0032357,GO:0033554,GO:0034039,GO:0034641,GO:0034644,GO:0035485,GO:0042769,GO:0043085,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045007,GO:0045786,GO:0045935,GO:0046483,GO:0048037,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051336,GO:0051345,GO:0051536,GO:0051539,GO:0051540,GO:0051606,GO:0051716,GO:0051726,GO:0060255,GO:0065007,GO:0065009,GO:0071214,GO:0071478,GO:0071482,GO:0071704,GO:0072421,GO:0080090,GO:0090304,GO:0097159,GO:0104004,GO:0140097,GO:1901360,GO:1901363,GO:1902799,GO:1902800,GO:1905777,GO:1905779 - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_732867_1 445686.E3SLA1_9CAUD 1.57e-133 403.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage 10239|Viruses S DNA polymerase family B - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004527,GO:0004540,GO:0005575,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016032,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018130,GO:0018995,GO:0019058,GO:0019079,GO:0019438,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0039686,GO:0039693,GO:0042025,GO:0042221,GO:0043170,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044403,GO:0044419,GO:0046483,GO:0050896,GO:0051704,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902074 - - - - - - - - - - - k59_941517_1 862965.PARA_17030 1.36e-52 188.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1Y81X@135625|Pasteurellales 135625|Pasteurellales J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_419378_1 1232437.KL662006_gene4384 1.15e-21 90.5 2E9PG@1|root,333VW@2|Bacteria,1NEU7@1224|Proteobacteria,42ZPQ@68525|delta/epsilon subdivisions,2WV1S@28221|Deltaproteobacteria,2MNDN@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_419378_2 472759.Nhal_3874 3.19e-90 273.0 COG1063@1|root,COG1063@2|Bacteria,1QXQ8@1224|Proteobacteria,1S1AP@1236|Gammaproteobacteria 1236|Gammaproteobacteria E PFAM Methylene-tetrahydromethanopterin dehydrogenase - - - ko:K10714 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 - R08059 RC00202 ko00000,ko00001,ko01000 - - - Mpt_N k59_1203219_1 387093.SUN_0501 3.03e-42 160.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,42Q71@68525|delta/epsilon subdivisions,2YMSG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Belongs to the 5'-nucleotidase family soxB - 3.1.3.6,3.1.4.16 ko:K01119,ko:K17224 ko00230,ko00240,ko00920,ko01100,ko01120,map00230,map00240,map00920,map01100,map01120 M00595 R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135,R10151 RC00078,RC00296,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 - - - 5_nucleotid_C,Metallophos k59_628711_1 436308.Nmar_1700 6.36e-160 456.0 COG1527@1|root,arCOG02459@2157|Archaea,41T18@651137|Thaumarchaeota 651137|Thaumarchaeota C ATP synthase (C/AC39) subunit - - - ko:K02119 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_AC39 k59_785348_1 796620.VIBC2010_02805 6.46e-11 65.5 COG0287@1|root,COG1605@1|root,COG0287@2|Bacteria,COG1605@2|Bacteria,1MVUT@1224|Proteobacteria,1RQB3@1236|Gammaproteobacteria,1XUE1@135623|Vibrionales 135623|Vibrionales E T-protein tyrA - 1.3.1.12,5.4.99.5 ko:K14187 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00024,M00025 R01715,R01728 RC00125,RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_2,PDH k59_785349_1 1123508.JH636441_gene3406 1.17e-22 100.0 COG1355@1|root,COG1355@2|Bacteria,2IZEZ@203682|Planctomycetes 203682|Planctomycetes S Memo-like protein - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_1098530_1 880070.Cycma_4553 1.65e-108 328.0 COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,4NM18@976|Bacteroidetes,47XKA@768503|Cytophagia 976|Bacteroidetes C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4_20,Pyr_redox_2 k59_628722_1 314278.NB231_16968 1.45e-79 251.0 COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,1RPYD@1236|Gammaproteobacteria,1WXKJ@135613|Chromatiales 135613|Chromatiales S Bacterial protein of unknown function (DUF853) - - - ko:K06915 - - - - ko00000 - - - DUF853 k59_629546_1 257313.BP0253 2.88e-31 126.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VJDW@28216|Betaproteobacteria,3T2J8@506|Alcaligenaceae 28216|Betaproteobacteria C carnitine dehydratase - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_263423_1 203122.Sde_1225 8.79e-90 272.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,1RZ5Q@1236|Gammaproteobacteria,46767@72275|Alteromonadaceae 1236|Gammaproteobacteria S membrane protein (homolog of Drosophila rhomboid) - - - - - - - - - - - - Rhomboid k59_263423_2 1370120.AUWR01000031_gene1464 7.73e-13 68.9 COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,232XA@1762|Mycobacteriaceae 201174|Actinobacteria C alcohol dehydrogenase - - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_315713_1 1247649.D560_3005 4.13e-05 45.1 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2VHQM@28216|Betaproteobacteria,3T2I4@506|Alcaligenaceae 28216|Betaproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_1204109_1 1215092.PA6_009_00330 2.64e-64 220.0 28P6A@1|root,2ZC10@2|Bacteria,1RBZE@1224|Proteobacteria,1RRNS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_994328_1 511051.CSE_00260 4.79e-57 195.0 COG2414@1|root,COG2414@2|Bacteria 2|Bacteria C aldehyde ferredoxin oxidoreductase activity aor - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS09915 AFOR_C,AFOR_N k59_1256271_1 1333523.L593_08630 1.1e-66 224.0 COG0281@1|root,arCOG00853@2157|Archaea,2XSTN@28890|Euryarchaeota,23SK1@183963|Halobacteria 183963|Halobacteria C COG0281 Malic enzyme - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_576635_1 1283299.AUKG01000002_gene4334 1.32e-35 129.0 COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria,4CSIF@84995|Rubrobacteria 84995|Rubrobacteria C Succinyl-CoA ligase like flavodoxin domain - - - - - - - - - - - - CoA_binding,Succ_CoA_lig k59_681784_1 313612.L8106_10192 6.11e-77 246.0 COG3387@1|root,COG3387@2|Bacteria,1G3VS@1117|Cyanobacteria,1H860@1150|Oscillatoriales 1117|Cyanobacteria G Glycosyl hydrolases family 15 - - - - - - - - - - - - Glyco_hydro_15 k59_681784_2 517418.Ctha_0553 2.92e-33 120.0 COG0239@1|root,COG0239@2|Bacteria,1FE6H@1090|Chlorobi 1090|Chlorobi D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB k59_681784_3 861299.J421_2336 7.43e-22 88.6 COG1993@1|root,COG1993@2|Bacteria 2|Bacteria T acr, cog1993 - - - ko:K09137 - - - - ko00000 - - - DUF190 k59_1256276_1 713586.KB900536_gene1028 4.73e-27 109.0 COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1RPTU@1236|Gammaproteobacteria,1WXF3@135613|Chromatiales 135613|Chromatiales I Membrane protein involved in aromatic hydrocarbon degradation - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_1256276_2 765914.ThisiDRAFT_0826 2.34e-23 95.9 2D186@1|root,32TA3@2|Bacteria,1N5ZE@1224|Proteobacteria,1S92Y@1236|Gammaproteobacteria,1WYYH@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_681793_1 187272.Mlg_2809 1.76e-85 261.0 COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,1RP2S@1236|Gammaproteobacteria,1X02A@135613|Chromatiales 135613|Chromatiales F Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose hldD - 5.1.3.20 ko:K03274 ko00540,ko01100,map00540,map01100 M00064 R05176 RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase k59_471937_1 247634.GPB2148_2100 3.66e-56 187.0 COG0477@1|root,COG2814@2|Bacteria,1R9EU@1224|Proteobacteria,1S0HE@1236|Gammaproteobacteria,1J8S9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EGP GEPR COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_1568997_1 748280.NH8B_1280 3.06e-67 207.0 COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,2VPZP@28216|Betaproteobacteria,2KQW5@206351|Neisseriales 206351|Neisseriales P Iron-storage protein bfr - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_315735_1 402881.Plav_1367 3.23e-20 90.1 COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,2U0CV@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - 1.14.13.235 ko:K22027 - - - - ko00000,ko01000 - - - Acyl-CoA_dh_2,Acyl-CoA_dh_N k59_315735_2 1282876.BAOK01000002_gene549 4.46e-35 130.0 COG1960@1|root,COG1960@2|Bacteria,1QU1U@1224|Proteobacteria,2TRIU@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1621575_1 1121937.AUHJ01000002_gene3592 1.62e-33 128.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,1RPRD@1236|Gammaproteobacteria,464JM@72275|Alteromonadaceae 1236|Gammaproteobacteria C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - 1.1.1.1,1.6.5.5 ko:K00001,ko:K00344 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_890370_1 83406.HDN1F_04230 7.74e-55 189.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4G2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains cbrB - - - - - - - - - - - Response_reg,Sigma54_activat k59_838030_1 444860.E3SIZ7_9CAUD 2.51e-35 127.0 4QDYQ@10239|Viruses,4QVVQ@35237|dsDNA viruses no RNA stage,4QPVQ@28883|Caudovirales,4QK1M@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1510_1 330214.NIDE3044 5.53e-95 299.0 COG4775@1|root,COG4775@2|Bacteria,3J0AC@40117|Nitrospirae 40117|Nitrospirae M Surface antigen - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_471952_1 1219065.VPR01S_02_00430 4.09e-48 157.0 COG2905@1|root,COG2905@2|Bacteria,1MZGY@1224|Proteobacteria,1S86K@1236|Gammaproteobacteria,1XXFK@135623|Vibrionales 135623|Vibrionales T COG0517 FOG CBS domain - - - - - - - - - - - - CBS k59_471952_2 1283300.ATXB01000001_gene2296 6.45e-48 156.0 COG0347@1|root,COG0347@2|Bacteria,1RI28@1224|Proteobacteria,1S62Z@1236|Gammaproteobacteria,1XFB1@135618|Methylococcales 135618|Methylococcales K Nitrogen regulatory protein P-II - - - - - - - - - - - - - k59_471952_3 870187.Thini_2730 6e-20 87.0 arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,1RMI8@1236|Gammaproteobacteria,461N8@72273|Thiotrichales 72273|Thiotrichales S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_1099311_1 604331.AUHY01000005_gene802 7.4e-66 215.0 COG0448@1|root,COG0448@2|Bacteria,1WIYD@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_1621590_2 1278073.MYSTI_06351 5.15e-77 240.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42MM0@68525|delta/epsilon subdivisions,2WKXZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria U AAA domain - - - - - - - - - - - - AAA_22 k59_106386_1 445684.E3SPX3_9CAUD 1.65e-122 358.0 4QAJD@10239|Viruses,4QW4M@35237|dsDNA viruses no RNA stage,4QQ7U@28883|Caudovirales,4QIAP@10662|Myoviridae 10662|Myoviridae S gp32 DNA binding protein like - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_106386_2 238854.Q5GQC3_BPSYP 7.88e-24 93.2 4QD1C@10239|Viruses,4QXXJ@35237|dsDNA viruses no RNA stage,4QQTB@28883|Caudovirales,4QIP9@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_228504_1 228410.NE0622 4.79e-10 58.2 COG0662@1|root,COG0662@2|Bacteria,1RFTK@1224|Proteobacteria,2WG1F@28216|Betaproteobacteria,374QB@32003|Nitrosomonadales 28216|Betaproteobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 k59_228504_2 247633.GP2143_07959 7.11e-44 160.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria 1236|Gammaproteobacteria I acyl-CoA dehydrogenase - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_77724_1 5501.XP_001248616.1 2.53e-42 164.0 COG1524@1|root,KOG2645@2759|Eukaryota,38EE7@33154|Opisthokonta,3NTVU@4751|Fungi,3QMRV@4890|Ascomycota,20BUG@147545|Eurotiomycetes,3B1SN@33183|Onygenales,3FMU7@34383|Onygenales incertae sedis 4751|Fungi S Type I phosphodiesterase / nucleotide pyrophosphatase - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004528,GO:0004551,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008081,GO:0008150,GO:0008152,GO:0009141,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0012505,GO:0016036,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0017111,GO:0019637,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034641,GO:0042578,GO:0042594,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - Phosphodiest k59_1433368_1 272134.KB731324_gene6649 3.33e-93 297.0 COG1554@1|root,COG1554@2|Bacteria,1G0DN@1117|Cyanobacteria,1HA78@1150|Oscillatoriales 1117|Cyanobacteria G Glycosyl hydrolase family 65 central catalytic domain - - 2.4.1.64 ko:K05342 ko00500,ko01100,map00500,map01100 - R02727 RC00049 ko00000,ko00001,ko01000 - GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m k59_809499_1 118163.Ple7327_2936 6.09e-119 357.0 COG3288@1|root,COG3288@2|Bacteria,1G1D1@1117|Cyanobacteria,3VIVK@52604|Pleurocapsales 1117|Cyanobacteria C PFAM Alanine dehydrogenase PNT, C-terminal domain pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_1528170_1 1121405.dsmv_0483 6.92e-108 325.0 COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2WJG1@28221|Deltaproteobacteria,2MHS7@213118|Desulfobacterales 28221|Deltaproteobacteria S Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k59_594231_1 1121918.ARWE01000001_gene2998 1.36e-29 115.0 COG0697@1|root,COG0697@2|Bacteria,1MXJY@1224|Proteobacteria,42RNT@68525|delta/epsilon subdivisions,2WNHN@28221|Deltaproteobacteria 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_594231_2 1461694.ATO9_02915 8.32e-32 125.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria,2PDN1@252301|Oceanicola 28211|Alphaproteobacteria C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_907994_1 582744.Msip34_2005 5.33e-35 135.0 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,2VMDE@28216|Betaproteobacteria,2KM0A@206350|Nitrosomonadales 206350|Nitrosomonadales N ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux k59_281261_1 1469245.JFBG01000046_gene2238 1.46e-84 267.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,1RSCT@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Aldehyde ferredoxin oxidoreductase ydhV GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016614,GO:0030151,GO:0033719,GO:0043167,GO:0043169,GO:0043546,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0097159,GO:1901363 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_1011921_1 644107.SL1157_2111 2.16e-13 68.9 COG0518@1|root,COG0518@2|Bacteria,1Q2KV@1224|Proteobacteria,2V70V@28211|Alphaproteobacteria,4NBF3@97050|Ruegeria 28211|Alphaproteobacteria F Glutamine amidotransferase class-I - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase k59_1011921_2 1122951.ATUE01000009_gene370 7.59e-30 120.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,3NKJE@468|Moraxellaceae 1236|Gammaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455,ko:K11745,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.1,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N k59_9089_1 436308.Nmar_0996 4.6e-61 190.0 arCOG05565@1|root,arCOG05565@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_9089_2 93059.P9211_06881 1.99e-13 68.6 COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,1MKI3@1212|Prochloraceae 1117|Cyanobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_1640046_1 1048339.KB913029_gene661 1.96e-68 222.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4ETYU@85013|Frankiales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K00666,ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1433396_1 88036.EFJ35406 2.41e-34 133.0 COG1233@1|root,KOG4254@2759|Eukaryota,37K3E@33090|Viridiplantae,3G9QZ@35493|Streptophyta 35493|Streptophyta H Pyridine nucleotide-disulfide oxidoreductase domain-containing protein - - - - - - - - - - - - Amino_oxidase,DAO,NAD_binding_8 k59_1279396_2 477184.KYC_02029 1.02e-137 406.0 COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2W96Q@28216|Betaproteobacteria,3T7AI@506|Alcaligenaceae 28216|Betaproteobacteria S MmgE/PrpD family - - - - - - - - - - - - MmgE_PrpD k59_1487129_1 765911.Thivi_2598 6.82e-34 124.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1WWUT@135613|Chromatiales 135613|Chromatiales C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1487129_2 713587.THITH_16990 8.88e-24 92.4 COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,1S9MD@1236|Gammaproteobacteria,1WYWM@135613|Chromatiales 135613|Chromatiales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_334779_1 1121405.dsmv_0361 0.000271 41.6 COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,42VWC@68525|delta/epsilon subdivisions,2WS5S@28221|Deltaproteobacteria,2MKV4@213118|Desulfobacterales 28221|Deltaproteobacteria S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 k59_334779_2 589865.DaAHT2_2537 5.88e-38 139.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2WJQ2@28221|Deltaproteobacteria,2MIIV@213118|Desulfobacterales 28221|Deltaproteobacteria H PFAM aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1065936_1 444860.E3SIT6_9CAUD 3.46e-65 202.0 4QG4U@10239|Viruses,4R0BW@35237|dsDNA viruses no RNA stage,4QS7Z@28883|Caudovirales,4QI8T@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_495269_1 59538.XP_005977321.1 2.36e-54 179.0 COG1143@1|root,KOG3256@2759|Eukaryota,38HK4@33154|Opisthokonta,3BBQ9@33208|Metazoa,3CU2A@33213|Bilateria,481V3@7711|Chordata,48ZAF@7742|Vertebrata,3JEVS@40674|Mammalia,4J6KM@91561|Cetartiodactyla 59538.XP_005977321.1|- C NADH dehydrogenase ubiquinone iron-sulfur protein - - - - - - - - - - - - - k59_495269_2 396588.Tgr7_0993 6.32e-183 516.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_1378545_1 1121405.dsmv_2859 3.7e-41 145.0 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,42SVD@68525|delta/epsilon subdivisions,2WPFX@28221|Deltaproteobacteria,2MJWM@213118|Desulfobacterales 28221|Deltaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_542610_1 1218108.KB908294_gene2300 1.3e-43 162.0 COG0514@1|root,COG0514@2|Bacteria,4NEB4@976|Bacteroidetes,1HXCJ@117743|Flavobacteriia 976|Bacteroidetes L ATP-dependent DNA helicase RecQ recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_856851_1 269797.Mbar_A2435 3.68e-42 158.0 COG0392@1|root,arCOG05231@2157|Archaea,2Y46N@28890|Euryarchaeota 28890|Euryarchaeota S lysyltransferase activity - - 2.3.2.3 ko:K07027,ko:K14205 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 - - ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 2.A.1.3.37,4.D.2 - - DUF2156,LPG_synthase_TM k59_282403_1 765911.Thivi_1033 2.49e-79 244.0 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,1WXA6@135613|Chromatiales 135613|Chromatiales H riboflavin synthase, alpha subunit - - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_1323603_1 472759.Nhal_3692 2.39e-32 117.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,1RN32@1236|Gammaproteobacteria,1WWN9@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_1323603_2 768671.ThimaDRAFT_0044 8.41e-71 221.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S65T@1236|Gammaproteobacteria,1WXHS@135613|Chromatiales 135613|Chromatiales C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_1225524_1 1232683.ADIMK_1859 2.88e-36 135.0 COG0457@1|root,COG0457@2|Bacteria,1QV5B@1224|Proteobacteria,1T292@1236|Gammaproteobacteria,46DDV@72275|Alteromonadaceae 1236|Gammaproteobacteria S Peptidase_C39 like family - - - - - - - - - - - - Peptidase_C39_2,TPR_16,TPR_19,TPR_8 k59_654071_1 1278073.MYSTI_05181 4.33e-08 54.7 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,42NPG@68525|delta/epsilon subdivisions,2WJVP@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_1435003_1 7213.XP_004533140.1 4.13e-40 150.0 COG0445@1|root,KOG2311@2759|Eukaryota,38BWB@33154|Opisthokonta,3BFG6@33208|Metazoa,3CTUH@33213|Bilateria,41TFM@6656|Arthropoda,3SKGZ@50557|Insecta,4520R@7147|Diptera 33208|Metazoa J Flavin adenine dinucleotide binding. It is involved in the biological process described with tRNA wobble uridine modification - - - - - - - - - - - - GIDA,GIDA_assoc,GidB k59_1641779_1 330214.NIDE1868 4.36e-104 333.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3J0UH@40117|Nitrospirae 40117|Nitrospirae H Pterin binding enzyme - - 2.1.1.13,2.1.1.258 ko:K00548,ko:K15023 ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230 M00017,M00377 R00946,R02289,R09365,R10243 RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans k59_1167234_1 436308.Nmar_0707 1.2e-58 189.0 COG2201@1|root,arCOG02382@2157|Archaea 2157|Archaea NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412,ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_1117892_1 1137799.GZ78_10180 4.36e-08 57.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1XJAY@135619|Oceanospirillales 135619|Oceanospirillales K Belongs to the sigma-70 factor family. ECF subfamily algU - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_701797_1 1299327.I546_1766 1.13e-08 57.0 COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,232VK@1762|Mycobacteriaceae 201174|Actinobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_1587647_1 555079.Toce_1070 2.37e-45 150.0 COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,24J83@186801|Clostridia,42GJ8@68295|Thermoanaerobacterales 186801|Clostridia J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_856885_1 1348657.M622_07475 5.31e-29 123.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VHTK@28216|Betaproteobacteria,2KUYQ@206389|Rhodocyclales 206389|Rhodocyclales T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,Response_reg k59_595406_1 766499.C357_01310 4.36e-09 57.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_595406_2 1442599.JAAN01000072_gene825 3.64e-06 54.3 COG1876@1|root,COG3409@1|root,COG1876@2|Bacteria,COG3409@2|Bacteria,1NAYN@1224|Proteobacteria,1SYR5@1236|Gammaproteobacteria,1XCSN@135614|Xanthomonadales 135614|Xanthomonadales M D-alanyl-D-alanine carboxypeptidase - - - ko:K17733 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M15_4 k59_1225560_1 338966.Ppro_0350 7e-37 141.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,43TM0@69541|Desulfuromonadales 28221|Deltaproteobacteria J TIGRFAM ribonuclease, Rne Rng family cafA - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_282433_1 436308.Nmar_1488 3.65e-88 275.0 COG0072@1|root,arCOG00412@2157|Archaea,41S8M@651137|Thaumarchaeota 651137|Thaumarchaeota J phenylalanyl-tRNA synthetase, beta subunit - - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5 k59_1378594_1 1172185.KB911513_gene4473 3.16e-09 59.3 COG3663@1|root,COG3663@2|Bacteria,2GNS5@201174|Actinobacteria,4FW6C@85025|Nocardiaceae 201174|Actinobacteria L Uracil DNA glycosylase superfamily mug - 3.2.2.28 ko:K03649 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1378594_2 1255043.TVNIR_2729 1.66e-10 61.6 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,1WX1J@135613|Chromatiales 135613|Chromatiales I Enoyl- acyl-carrier-protein reductase NADH - - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1641812_1 1415779.JOMH01000001_gene1861 5.8e-05 46.6 COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria,1X7FN@135614|Xanthomonadales 135614|Xanthomonadales HJ Prokaryotic glutathione synthetase, ATP-grasp domain - - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - Acetyltransf_1,Mur_ligase_C,Mur_ligase_M,RimK k59_1378595_1 1266909.AUAG01000041_gene1362 4.42e-26 99.8 COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,1S5V4@1236|Gammaproteobacteria,1WYBY@135613|Chromatiales 135613|Chromatiales L PFAM HNH endonuclease - - - - - - - - - - - - HNH k59_495353_1 502025.Hoch_4174 8.17e-13 66.6 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,42V63@68525|delta/epsilon subdivisions,2X5QF@28221|Deltaproteobacteria,2Z36V@29|Myxococcales 28221|Deltaproteobacteria K Transcriptional regulator - - - - - - - - - - - - Rrf2 k59_495353_2 64363.EME43777 1.39e-13 77.0 COG1205@1|root,KOG4150@2759|Eukaryota,38FJG@33154|Opisthokonta,3NUXJ@4751|Fungi,3QKQR@4890|Ascomycota,1ZYPE@147541|Dothideomycetes,3MG1B@451867|Dothideomycetidae 4751|Fungi A DNA replication factor CDT1 like HRQ1 GO:0000166,GO:0000217,GO:0000405,GO:0000733,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005730,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0031974,GO:0031981,GO:0032392,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034644,GO:0035639,GO:0035861,GO:0036094,GO:0036297,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070013,GO:0070035,GO:0070914,GO:0071103,GO:0071214,GO:0071478,GO:0071482,GO:0071704,GO:0071840,GO:0090304,GO:0090734,GO:0097159,GO:0097367,GO:0104004,GO:0140097,GO:0140098,GO:1901255,GO:1901265,GO:1901360,GO:1901363 - ko:K06877 - - - - ko00000 - - - CDT1,DEAD,DUF1998,Helicase_C k59_1529060_1 261292.Nit79A3_2959 1.14e-79 255.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,372QB@32003|Nitrosomonadales 28216|Betaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1587667_2 1280948.HY36_06100 0.000439 44.3 COG0845@1|root,COG0845@2|Bacteria,1MX8W@1224|Proteobacteria,2TRPM@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MA20_37100 - - ko:K15727 - - - - ko00000,ko02000 8.A.1.2.1 - - Biotin_lipoyl_2,HlyD_D23 k59_542659_1 1229909.NSED_09535 8.57e-76 230.0 COG0237@1|root,arCOG01045@2157|Archaea,41SI8@651137|Thaumarchaeota 651137|Thaumarchaeota H AAA domain - - - - - - - - - - - - AAA_17 k59_79469_1 697282.Mettu_1587 1.03e-22 96.3 COG1533@1|root,COG1533@2|Bacteria,1NWJ9@1224|Proteobacteria,1SMJU@1236|Gammaproteobacteria,1XDZQ@135618|Methylococcales 135618|Methylococcales L radical SAM domain protein - - 4.1.99.14 ko:K03716 - - - - ko00000,ko01000 - - - - k59_79469_2 1267535.KB906767_gene5103 3.21e-21 91.3 COG0667@1|root,COG0667@2|Bacteria,3Y2TN@57723|Acidobacteria,2JMH3@204432|Acidobacteriia 204432|Acidobacteriia C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_1066016_1 1280953.HOC_06478 1.3e-28 120.0 COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2TTMN@28211|Alphaproteobacteria,43XB8@69657|Hyphomonadaceae 28211|Alphaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_14,TPR_16,TPR_19,TPR_2,TPR_8 k59_389195_1 981336.F944_03075 4.05e-20 87.4 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,3NJVA@468|Moraxellaceae 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iSSON_1240.SSON_3886,iYL1228.KPN_04138 ATP-synt k59_389195_2 323261.Noc_3074 3.84e-89 275.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1WW2C@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_495367_1 679926.Mpet_0068 2.04e-59 197.0 COG3635@1|root,arCOG01696@2157|Archaea,2XU1U@28890|Euryarchaeota,2N95W@224756|Methanomicrobia 224756|Methanomicrobia G phosphoglycerate mutase apgM - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase k59_701829_1 580332.Slit_1495 1.22e-08 53.1 COG2920@1|root,COG2920@2|Bacteria,1NAQC@1224|Proteobacteria,2VWA3@28216|Betaproteobacteria 28216|Betaproteobacteria P DsrC like protein - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_1488780_1 436308.Nmar_1722 3.13e-54 177.0 COG0500@1|root,arCOG04347@2157|Archaea,41T35@651137|Thaumarchaeota 651137|Thaumarchaeota Q Nodulation protein S (NodS) - - - - - - - - - - - - - k59_542666_1 1121374.KB891585_gene2415 9.21e-12 68.6 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2206 HD-GYP domain - - - - - - - - - - - - DUF3391,HD,HD_5 k59_751944_1 247490.KSU1_C1305 5.57e-125 375.0 COG0296@1|root,COG0296@2|Bacteria,2IXS1@203682|Planctomycetes 203682|Planctomycetes G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_495385_1 1229909.NSED_05500 3.16e-16 75.5 COG0640@1|root,arCOG03067@2157|Archaea,41TA3@651137|Thaumarchaeota 651137|Thaumarchaeota K transcriptional regulators - - - - - - - - - - - - - k59_1587690_1 96561.Dole_1175 2.88e-90 282.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2WITH@28221|Deltaproteobacteria,2MHR7@213118|Desulfobacterales 28221|Deltaproteobacteria G phosphoglucomutase phosphomannomutase alpha beta alpha domain I algC - 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_439568_1 305900.GV64_18830 4.15e-94 295.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1XHBX@135619|Oceanospirillales 135619|Oceanospirillales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_595444_2 1166948.JPZL01000004_gene107 4.26e-40 141.0 COG3618@1|root,COG3618@2|Bacteria,1MVG0@1224|Proteobacteria,1RNCH@1236|Gammaproteobacteria,1XMQN@135619|Oceanospirillales 135619|Oceanospirillales S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1236157_1 1207063.P24_18556 1.55e-140 406.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria,2JQNJ@204441|Rhodospirillales 204441|Rhodospirillales E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_90587_1 1298593.TOL_1615 3.01e-65 212.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,1XHH6@135619|Oceanospirillales 135619|Oceanospirillales E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) aroF-1 - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_1595703_1 369723.Strop_3225 6.7e-43 160.0 COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,4DAJQ@85008|Micromonosporales 201174|Actinobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_710012_2 1219045.BV98_003436 2.45e-34 127.0 COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria,2K2BK@204457|Sphingomonadales 204457|Sphingomonadales Q taurine catabolism dioxygenase - - 1.14.11.17 ko:K03119,ko:K22303 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_1386214_1 1487953.JMKF01000009_gene6135 1.51e-75 236.0 COG0435@1|root,COG0435@2|Bacteria,1G0WI@1117|Cyanobacteria,1H7YP@1150|Oscillatoriales 1117|Cyanobacteria O PFAM Glutathione S-transferase, C-terminal domain - - 1.8.5.7 ko:K07393 - - - - ko00000,ko01000 - - - GST_C_2,GST_N_2 k59_90606_1 716544.wcw_0148 3.11e-55 183.0 COG1533@1|root,COG1533@2|Bacteria,2JFM3@204428|Chlamydiae 204428|Chlamydiae L DNA photolyase activity - - 4.1.99.14 ko:K03716 - - - - ko00000,ko01000 - - - - k59_1021253_1 373994.Riv7116_6487 3.15e-79 240.0 COG0500@1|root,COG2226@2|Bacteria,1G4JV@1117|Cyanobacteria 1117|Cyanobacteria Q Methylase involved in ubiquinone menaquinone biosynthesis - - - - - - - - - - - - Methyltransf_31 k59_1292507_1 880071.Fleli_1727 2.82e-64 214.0 COG0334@1|root,COG0334@2|Bacteria,4NEBH@976|Bacteroidetes,47K4Z@768503|Cytophagia 976|Bacteroidetes E Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_665523_1 1123376.AUIU01000011_gene922 5.57e-98 303.0 COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae 40117|Nitrospirae M Evidence 2a Function of homologous gene experimentally demonstrated in an other organism - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1653261_1 330214.NIDE0255 8.1e-22 93.2 COG1826@1|root,COG1826@2|Bacteria 2|Bacteria U protein secretion tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_918975_1 1229909.NSED_03595 7.68e-38 131.0 COG0638@1|root,arCOG00970@2157|Archaea,41SGS@651137|Thaumarchaeota 651137|Thaumarchaeota O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation - - 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome k59_918975_2 1229909.NSED_03600 2.2e-79 239.0 COG2016@1|root,arCOG00985@2157|Archaea,41SSC@651137|Thaumarchaeota 651137|Thaumarchaeota J PUA domain - - - ko:K07575 - - - - ko00000 - - - PUA k59_918975_3 1229909.NSED_03605 3.64e-28 109.0 COG0460@1|root,arCOG01351@2157|Archaea,41SAC@651137|Thaumarchaeota 651137|Thaumarchaeota E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - Homoserine_dh,NAD_binding_3 k59_1500048_1 396588.Tgr7_1445 1.02e-31 124.0 COG2199@1|root,COG2199@2|Bacteria,1MVSA@1224|Proteobacteria,1RP1K@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase yeaP GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0052621 2.7.7.65 ko:K13069,ko:K21021 ko02025,map02025 - R08057 - ko00000,ko00001,ko01000 - - - GAF,GAF_2,GAF_3,GGDEF k59_449889_1 330214.NIDE1012 2.38e-41 141.0 COG1714@1|root,COG1714@2|Bacteria,3J0U3@40117|Nitrospirae 40117|Nitrospirae S RDD family - - - - - - - - - - - - RDD k59_449889_2 330214.NIDE1013 3.13e-34 125.0 COG1077@1|root,COG1077@2|Bacteria,3J0BS@40117|Nitrospirae 40117|Nitrospirae D Actin - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_1444783_1 706587.Desti_2776 4.16e-98 302.0 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,42MBU@68525|delta/epsilon subdivisions,2WIJP@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM AAA ATPase central domain protein - - 3.6.4.6 ko:K06027 ko04138,ko04721,ko04727,ko04962,map04138,map04721,map04727,map04962 - - - ko00000,ko00001,ko01000,ko04131 1.F.1.1 - - AAA k59_237952_1 443144.GM21_0962 1.53e-11 66.2 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,43TKB@69541|Desulfuromonadales 28221|Deltaproteobacteria T response regulator ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_237952_2 579137.Metvu_0744 1.78e-21 98.2 COG1641@1|root,arCOG02701@2157|Archaea,2XV3G@28890|Euryarchaeota,23QR0@183939|Methanococci 183939|Methanococci S Belongs to the LarC family - - 4.99.1.12 ko:K09121 - - - - ko00000,ko01000 - - - DUF111 k59_506629_1 522306.CAP2UW1_1312 3.15e-21 93.6 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VI6T@28216|Betaproteobacteria,1KQH5@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_3,PAS_4 k59_506629_2 402881.Plav_2041 5.5e-59 191.0 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2TUND@28211|Alphaproteobacteria,1JQM0@119043|Rhodobiaceae 28211|Alphaproteobacteria K helix_turn_helix, Lux Regulon fixJ - - ko:K14987 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_1444787_1 1523503.JPMY01000036_gene1488 6.07e-17 85.5 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1S0C5@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,Hemerythrin,PAS_3 k59_710057_1 1528106.JRJE01000009_gene1753 5.38e-74 232.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2TSK2@28211|Alphaproteobacteria,2JQUY@204441|Rhodospirillales 204441|Rhodospirillales S transport system periplasmic component - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_760042_1 547144.HydHO_0714 3.49e-97 294.0 COG3176@1|root,COG3176@2|Bacteria 2|Bacteria S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_5 k59_760042_2 547144.HydHO_0695 5.4e-12 67.4 COG0204@1|root,COG0204@2|Bacteria 2|Bacteria I Acyl-transferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_665569_1 903818.KI912268_gene1318 2.7e-58 195.0 COG0702@1|root,COG0702@2|Bacteria,3Y7DF@57723|Acidobacteria 57723|Acidobacteria GM Protein of unknown function (DUF2867) - - - - - - - - - - - - DUF2867,NAD_binding_10 k59_1127681_1 1157490.EL26_23105 1.16e-23 102.0 COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,4IQKZ@91061|Bacilli 91061|Bacilli O Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins prsA - 5.2.1.8 ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3,SurA_N_3 k59_919018_1 572478.Vdis_0122 1.54e-65 207.0 COG0500@1|root,arCOG01773@2157|Archaea,2XRWU@28889|Crenarchaeota 28889|Crenarchaeota Q Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11 k59_919022_1 1038869.AXAN01000091_gene815 5.4e-15 75.1 COG0526@1|root,COG1773@1|root,COG0526@2|Bacteria,COG1773@2|Bacteria,1MV2U@1224|Proteobacteria,2VKNQ@28216|Betaproteobacteria,1K5MW@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM HupH hydrogenase expression protein hoxQ - - ko:K03618 - - - - ko00000 - - - HupH_C k59_919022_2 983917.RGE_35840 4.34e-24 92.8 COG1773@1|root,COG1773@2|Bacteria,1N6TQ@1224|Proteobacteria,2VWD0@28216|Betaproteobacteria,1KMQ9@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Rubredoxin hoxR - - - - - - - - - - - Rubredoxin k59_137068_1 768066.HELO_2241 9.64e-18 87.4 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,1RMB0@1236|Gammaproteobacteria,1XI63@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k59_344250_1 883103.HMPREF9703_00004 2.27e-44 152.0 COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,4HAPT@91061|Bacilli,27FHI@186828|Carnobacteriaceae 91061|Bacilli G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_344250_2 1156937.MFUM_170034 2.55e-13 66.6 COG1314@1|root,COG1314@2|Bacteria,46T75@74201|Verrucomicrobia,37H11@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia U Preprotein translocase SecG subunit secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_919029_1 856793.MICA_739 1.28e-45 166.0 COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,4BPAB@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle yejA - - ko:K02035,ko:K13893 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 k59_137079_2 243275.TDE_1049 1.4e-36 139.0 COG0480@1|root,COG0480@2|Bacteria,2J5M8@203691|Spirochaetes 203691|Spirochaetes J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1236248_1 402626.Rpic_4863 4e-58 188.0 COG0745@1|root,COG0745@2|Bacteria,1N7TJ@1224|Proteobacteria,2WEAK@28216|Betaproteobacteria,1K11E@119060|Burkholderiaceae 28216|Betaproteobacteria K response regulator - - - ko:K02483,ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1127702_1 1237149.C900_02383 1.11e-91 282.0 28KRY@1|root,2ZA9E@2|Bacteria,4NI1H@976|Bacteroidetes,47N4R@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1444829_1 187272.Mlg_1667 1.69e-11 64.3 COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,1RSMW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_603497_1 649747.HMPREF0083_02709 4.48e-75 237.0 COG0045@1|root,COG0045@2|Bacteria,1TQG4@1239|Firmicutes,4HA3W@91061|Bacilli,26RFR@186822|Paenibacillaceae 91061|Bacilli C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_919046_1 330214.NIDE1955 2.9e-46 169.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria 2|Bacteria S CHAT domain - - - - - - - - - - - - CHAT,TPR_10,TPR_12,TPR_16,TPR_7,TPR_8 k59_865158_1 1163617.SCD_n00628 1.03e-101 301.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2VHSD@28216|Betaproteobacteria 28216|Betaproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_665607_1 468059.AUHA01000002_gene1161 5.08e-32 129.0 COG0673@1|root,COG1063@1|root,COG0673@2|Bacteria,COG1063@2|Bacteria,4NFEW@976|Bacteroidetes 976|Bacteroidetes E Oxidoreductase NAD-binding domain protein - - - ko:K02030,ko:K03810 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - ADH_zinc_N,GFO_IDH_MocA k59_1386287_1 498211.CJA_0066 6.22e-68 220.0 COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,1RYRV@1236|Gammaproteobacteria,1FGHP@10|Cellvibrio 1236|Gammaproteobacteria M Glycosyl transferases group 1 gt4G - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_344279_1 395493.BegalDRAFT_1908 3.15e-50 168.0 COG1192@1|root,COG1192@2|Bacteria,1MWRE@1224|Proteobacteria,1RMZN@1236|Gammaproteobacteria,462HG@72273|Thiotrichales 72273|Thiotrichales D AAA domain - - - - - - - - - - - - AAA_31,CbiA k59_919057_2 1137745.H6WFS1_9CAUD 4.03e-25 95.1 4QGUY@10239|Viruses,4QYK4@35237|dsDNA viruses no RNA stage,4QSCF@28883|Caudovirales,4QJJV@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_919057_3 444861.E3SPS0_9CAUD 3.6e-18 76.6 4QBH4@10239|Viruses,4QX2C@35237|dsDNA viruses no RNA stage,4QQ8P@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1444843_1 1208321.D104_11805 5.19e-72 235.0 COG0754@1|root,COG3942@1|root,COG0754@2|Bacteria,COG3942@2|Bacteria,1MW6V@1224|Proteobacteria,1RQAP@1236|Gammaproteobacteria,1XHKB@135619|Oceanospirillales 135619|Oceanospirillales E Glutathionylspermidine synthase - - 3.5.1.78,6.3.1.8 ko:K01460 ko00480,ko01100,map00480,map01100 - R01917,R01918 RC00090,RC00096 ko00000,ko00001,ko01000 - - - CHAP,GSP_synth k59_968721_1 331869.BAL199_12941 5.58e-57 189.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2VFEC@28211|Alphaproteobacteria,4BQWR@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1174574_1 913325.N799_04875 6.07e-86 265.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,1RQAK@1236|Gammaproteobacteria,1X3U8@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the reversible formation of glyoxylate and succinate from isocitrate aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_603512_1 273057.SSO3205 2.54e-06 53.1 COG0517@1|root,arCOG00600@2157|Archaea 2157|Archaea K CBS domain - - - - - - - - - - - - CBS k59_1174580_1 96561.Dole_0659 3.61e-36 123.0 COG3514@1|root,COG3514@2|Bacteria,1PWSE@1224|Proteobacteria,43A9S@68525|delta/epsilon subdivisions,2WTC0@28221|Deltaproteobacteria,2MP7T@213118|Desulfobacterales 28221|Deltaproteobacteria S BrnA antitoxin of type II toxin-antitoxin system - - - - - - - - - - - - - k59_1174580_2 96561.Dole_0658 9.9e-42 139.0 COG2929@1|root,COG2929@2|Bacteria,1N6QP@1224|Proteobacteria,42VMA@68525|delta/epsilon subdivisions,2WS3K@28221|Deltaproteobacteria,2MKVT@213118|Desulfobacterales 28221|Deltaproteobacteria S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - ko:K09803 - - - - ko00000 - - - BrnT_toxin k59_1330894_1 1123367.C666_01385 1.35e-69 222.0 COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2VMEV@28216|Betaproteobacteria,2KVW6@206389|Rhodocyclales 206389|Rhodocyclales I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_6 k59_1386307_1 543728.Vapar_3820 2.04e-47 162.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2VJ2T@28216|Betaproteobacteria,4AH60@80864|Comamonadaceae 28216|Betaproteobacteria C D-isomer specific 2-hydroxyacid dehydrogenase serA2 - 1.1.1.310,1.1.1.399,1.1.1.95 ko:K00058,ko:K16843 ko00260,ko00270,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513,R05693 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_824069_1 1242864.D187_007533 7.07e-56 195.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,42SWK@68525|delta/epsilon subdivisions,2WPU0@28221|Deltaproteobacteria,2YUSY@29|Myxococcales 28221|Deltaproteobacteria H tRNA nucleotidyltransferase domain 2 putative - - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 k59_920323_1 444860.E3SIZ0_9CAUD 1.44e-62 211.0 4QF7I@10239|Viruses,4QYCA@35237|dsDNA viruses no RNA stage,4QT9A@28883|Caudovirales,4QKJH@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_293262_1 65093.PCC7418_0574 1.01e-73 232.0 COG2152@1|root,COG2152@2|Bacteria,1GCHI@1117|Cyanobacteria 1117|Cyanobacteria G Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose - - - - - - - - - - - - - k59_1501448_1 318161.Sden_3101 1.92e-26 108.0 COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,2QAQ7@267890|Shewanellaceae 1236|Gammaproteobacteria S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_969693_1 525146.Ddes_0890 4.16e-53 183.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42N89@68525|delta/epsilon subdivisions,2WIUT@28221|Deltaproteobacteria,2M7ZS@213115|Desulfovibrionales 28221|Deltaproteobacteria M PDZ DHR GLGF domain protein - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1445752_1 97139.C824_02033 9.92e-22 93.6 COG0801@1|root,COG1539@1|root,COG0801@2|Bacteria,COG1539@2|Bacteria,1V6PR@1239|Firmicutes,249YP@186801|Clostridia,36ECT@31979|Clostridiaceae 186801|Clostridia H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folK - 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 - - - FolB,HPPK k59_91937_2 2325.TKV_c11910 7.31e-33 124.0 COG0263@1|root,COG0263@2|Bacteria,1TPG6@1239|Firmicutes,2486P@186801|Clostridia,42FBI@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_1175480_1 330214.NIDE3392 3.84e-65 219.0 COG1449@1|root,COG1449@2|Bacteria,3J0AQ@40117|Nitrospirae 40117|Nitrospirae G Glycosyl hydrolase family 57 - - - - - - - - - - - - Glyco_hydro_57 k59_1293960_2 68194.JNXR01000003_gene3295 6.06e-53 178.0 COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria 201174|Actinobacteria I Belongs to the thiolase family - - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1293966_1 1388763.O165_002555 5.52e-23 94.4 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,1YWNN@136845|Pseudomonas putida group 1236|Gammaproteobacteria H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_2376 Methyltransf_23 k59_1293966_2 882378.RBRH_00057 2.25e-30 117.0 COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,2VS13@28216|Betaproteobacteria,1JZZC@119060|Burkholderiaceae 28216|Betaproteobacteria G Phosphoglycolate phosphatase gph - 3.1.3.105 ko:K22292 ko00520,map00520 - R11785 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_1128971_1 1131266.ARWQ01000028_gene1019 6.63e-08 51.6 COG1730@1|root,arCOG01341@2157|Archaea,41SSP@651137|Thaumarchaeota 651137|Thaumarchaeota O Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding pfdA - - ko:K04797 - - - - ko00000,ko03110 - - - Prefoldin k59_1128971_2 1229909.NSED_09435 1.18e-37 130.0 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1128971_3 1229909.NSED_01900 2.14e-41 140.0 COG0605@1|root,arCOG04147@2157|Archaea,41S6C@651137|Thaumarchaeota 651137|Thaumarchaeota P Destroys radicals which are normally produced within the cells and which are toxic to biological systems - - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_1445768_1 326423.RBAM_034480 8.51e-06 49.3 COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,4HAR3@91061|Bacilli,1ZBP1@1386|Bacillus 91061|Bacilli J Arginyl-tRNA synthetase argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_1445768_2 220668.lp_0997 9.05e-06 44.7 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli,3F7FW@33958|Lactobacillaceae 91061|Bacilli K Cold shock protein cspC - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_1293970_1 243233.MCA1037 3.74e-168 495.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1XEAI@135618|Methylococcales 135618|Methylococcales L DNA helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_711091_1 1123355.JHYO01000010_gene3436 1.55e-62 210.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,36Y4A@31993|Methylocystaceae 28211|Alphaproteobacteria E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_100125_1 765914.ThisiDRAFT_2398 6.48e-86 258.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1WVXJ@135613|Chromatiales 135613|Chromatiales O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_353539_1 404589.Anae109_2759 3.1e-67 213.0 COG2010@1|root,COG2010@2|Bacteria,1RDSI@1224|Proteobacteria,42WEW@68525|delta/epsilon subdivisions 1224|Proteobacteria C cytochrome c norC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02305 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002 3.D.4.10 - - Cytochrom_C k59_458808_1 443143.GM18_2337 9.64e-33 119.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,42S15@68525|delta/epsilon subdivisions,2WNI1@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_559446_1 1122185.N792_13355 7.11e-57 192.0 COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,1RPN7@1236|Gammaproteobacteria,1X4BQ@135614|Xanthomonadales 135614|Xanthomonadales E peptidase M20 - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_1665142_1 1121033.AUCF01000003_gene3320 3.59e-49 177.0 COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,2TRSY@28211|Alphaproteobacteria,2JPPS@204441|Rhodospirillales 204441|Rhodospirillales V ABC transporter transmembrane region - - - ko:K02021 - - - - ko00000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran,cNMP_binding k59_834434_1 1168034.FH5T_03280 7.23e-66 224.0 COG0457@1|root,COG0823@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins dppX - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 k59_977063_1 1123242.JH636434_gene5621 6.56e-61 203.0 COG0702@1|root,COG0702@2|Bacteria,2IYQV@203682|Planctomycetes 203682|Planctomycetes GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - DUF2867,NAD_binding_10 k59_1393542_1 525255.HMPREF0077_2006 3.54e-13 70.9 COG0745@1|root,COG0745@2|Bacteria,1TQY9@1239|Firmicutes,24D6A@186801|Clostridia,22H27@1570339|Peptoniphilaceae 186801|Clostridia K Response regulator receiver domain protein phoB - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1393542_2 324602.Caur_1394 2.56e-27 110.0 COG1235@1|root,COG1235@2|Bacteria,2G833@200795|Chloroflexi 200795|Chloroflexi S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_1543762_1 1293054.HSACCH_00638 5.19e-90 275.0 COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,3WAA2@53433|Halanaerobiales 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_353573_1 402777.KB235904_gene3166 1.58e-06 55.8 COG2905@1|root,COG5000@1|root,COG5001@1|root,COG2905@2|Bacteria,COG5000@2|Bacteria,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria,1H9V4@1150|Oscillatoriales 1117|Cyanobacteria T Diguanylate cyclase - - - - - - - - - - - - CBS,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1511841_1 314287.GB2207_01597 3.26e-10 57.4 2EAR8@1|root,334TE@2|Bacteria,1NDFF@1224|Proteobacteria,1SCX2@1236|Gammaproteobacteria,1J6FX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1511841_2 756067.MicvaDRAFT_3597 1.52e-80 244.0 COG0175@1|root,COG0175@2|Bacteria,1G1RY@1117|Cyanobacteria,1H7BQ@1150|Oscillatoriales 1117|Cyanobacteria EH Reduction of activated sulfate into sulfite cysH GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_1029502_1 519989.ECTPHS_03267 5.06e-126 371.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1WWIR@135613|Chromatiales 135613|Chromatiales H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_403960_1 1355368.JART01000019_gene1149 6.51e-07 48.9 COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,42SBM@68525|delta/epsilon subdivisions,2YPGH@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox k59_403960_2 370438.PTH_2522 1.02e-39 147.0 COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,2613E@186807|Peptococcaceae 186801|Clostridia J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_518428_1 521674.Plim_2830 5.1e-20 85.5 COG1943@1|root,COG1943@2|Bacteria 2|Bacteria L Transposase - - - ko:K07491 - - - - ko00000 - - - - k59_768012_1 398525.KB900701_gene6422 3.52e-05 45.8 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria,3JSMR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Flavin-binding monooxygenase-like MA20_14940 - 1.14.13.84 ko:K14520 ko00363,ko01100,ko01120,map00363,map01100,map01120 - R06892 RC01644 ko00000,ko00001,ko01000 - - - FMO-like,K_oxygenase,NAD_binding_8,Pyr_redox_3 k59_768012_2 1479237.JMLY01000001_gene3299 4.18e-45 150.0 2CD0I@1|root,32RWS@2|Bacteria,1N0MC@1224|Proteobacteria,1SABW@1236|Gammaproteobacteria,46827@72275|Alteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4399) - - - - - - - - - - - - DUF4399 k59_1137070_1 298653.Franean1_4518 1.64e-73 230.0 COG2084@1|root,COG2084@2|Bacteria 2|Bacteria I phosphogluconate dehydrogenase (decarboxylating) activity - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_610930_1 444860.E3SIR0_9CAUD 1.39e-67 220.0 4QEKP@10239|Viruses,4QXCW@35237|dsDNA viruses no RNA stage,4QUCM@28883|Caudovirales,4QI72@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_518439_1 362976.HQ_3464A 5.59e-17 84.7 COG3119@1|root,arCOG02787@2157|Archaea,2XUWX@28890|Euryarchaeota,23S64@183963|Halobacteria 183963|Halobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1,3.1.6.6 ko:K01130,ko:K01133 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_1338182_2 1469245.JFBG01000023_gene1281 2.29e-43 144.0 COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,1SA21@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Ferredoxin - - - ko:K04755 - - - - ko00000 - - - Fer2 k59_1338182_3 1469245.JFBG01000023_gene1280 3.73e-16 77.8 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,1X2DA@135613|Chromatiales 135613|Chromatiales S Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Reductase_C k59_1511883_1 246196.MSMEI_0221 1.25e-21 105.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,2364D@1762|Mycobacteriaceae 201174|Actinobacteria T PFAM Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,Guanylate_cyc k59_403993_1 1219045.BV98_000702 1.32e-53 184.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2TVFM@28211|Alphaproteobacteria,2K114@204457|Sphingomonadales 204457|Sphingomonadales J Metallo-beta-lactamase superfamily domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_1137104_1 290512.Paes_1538 5.28e-17 85.5 COG0373@1|root,COG0373@2|Bacteria,1FDBA@1090|Chlorobi 1090|Chlorobi H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_677436_1 76114.ebA3149 3.18e-35 135.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2W05E@28216|Betaproteobacteria,2KXVV@206389|Rhodocyclales 206389|Rhodocyclales C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,POR_N k59_677436_2 1267211.KI669560_gene722 1.44e-18 83.6 COG1013@1|root,COG1013@2|Bacteria,4NIE0@976|Bacteroidetes,1IZ5W@117747|Sphingobacteriia 976|Bacteroidetes C COGs COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductase beta subunit oorB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_1665273_1 1229909.NSED_03795 5.07e-76 240.0 arCOG08801@1|root,arCOG08801@2157|Archaea 2157|Archaea S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - - k59_188892_1 991905.SL003B_0832 2.57e-63 200.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,4BRCY@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter cysA - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_188892_2 1380394.JADL01000002_gene1101 4.86e-92 278.0 COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,2TTF5@28211|Alphaproteobacteria,2JRHQ@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_518497_1 1115512.EH105704_02_03200 3.31e-76 239.0 COG4143@1|root,COG4143@2|Bacteria,1MUBB@1224|Proteobacteria,1RMQ9@1236|Gammaproteobacteria,3XNCI@561|Escherichia 1236|Gammaproteobacteria P Periplasmic protein tbpA GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0008144,GO:0008150,GO:0015888,GO:0015893,GO:0019842,GO:0030288,GO:0030313,GO:0030975,GO:0030976,GO:0031975,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0045117,GO:0048037,GO:0050662,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0071702,GO:0071705,GO:0072348,GO:0097159,GO:1901363,GO:1901681 - ko:K02064 ko02010,map02010 M00191 - - ko00000,ko00001,ko00002,ko02000 3.A.1.19 - iAPECO1_1312.APECO1_1914,iSFxv_1172.SFxv_0065,iUTI89_1310.UTI89_C0076 SBP_bac_1,SBP_bac_11,SBP_bac_6,SBP_bac_8 k59_834565_1 211165.AJLN01000047_gene6210 2.37e-96 291.0 COG0399@1|root,COG0399@2|Bacteria,1G0IM@1117|Cyanobacteria,1JHSZ@1189|Stigonemataceae 1117|Cyanobacteria M DegT/DnrJ/EryC1/StrS aminotransferase family - - 2.6.1.102,2.6.1.33 ko:K13010,ko:K20429 ko00520,map00520 - R02773,R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k59_718617_1 1122223.KB890699_gene516 1.85e-50 166.0 COG2606@1|root,COG2606@2|Bacteria,1WJSU@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S YbaK prolyl-tRNA synthetase associated ebsC - - - - - - - - - - - tRNA_edit k59_977152_1 1357423.S5MV44_9CAUD 1.28e-07 57.4 4QHDM@10239|Viruses,4QYV6@35237|dsDNA viruses no RNA stage,4QRD0@28883|Caudovirales,4QI2W@10662|Myoviridae 10662|Myoviridae S Terminase-like family - GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016032,GO:0016043,GO:0016787,GO:0016788,GO:0019058,GO:0019068,GO:0019069,GO:0019072,GO:0019075,GO:0022607,GO:0032991,GO:0034641,GO:0043170,GO:0043493,GO:0044085,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0046483,GO:0046797,GO:0051704,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0098009,GO:1901360,GO:1902494,GO:1904949 - - - - - - - - - - - k59_17942_1 367336.OM2255_11320 4.38e-63 216.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system large permease component - - - - - - - - - - - - DctM k59_1305824_1 523791.Kkor_2316 6.69e-21 101.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1XI3R@135619|Oceanospirillales 135619|Oceanospirillales NU secretion pathway protein - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_519902_2 1265313.HRUBRA_00447 8.18e-07 50.4 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria I acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1030527_1 864069.MicloDRAFT_00008910 9e-39 140.0 COG0667@1|root,COG0667@2|Bacteria,1MWGQ@1224|Proteobacteria,2TUJ8@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Aldo keto reductase - - 1.1.1.122 ko:K00064 ko00051,ko00053,ko01100,ko01110,ko01120,map00051,map00053,map01100,map01110,map01120 M00114 R07675,R08926 RC00066,RC00161 ko00000,ko00001,ko00002,ko01000 - - - Aldo_ket_red k59_1086047_2 289376.THEYE_A1393 2.03e-29 115.0 COG0558@1|root,COG0558@2|Bacteria 2|Bacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA1 - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf,DUF4833 k59_1513206_1 1131266.ARWQ01000001_gene1322 6.49e-42 140.0 arCOG08817@1|root,arCOG08817@2157|Archaea,41SV5@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1513206_2 436308.Nmar_0045 6.58e-38 130.0 arCOG10514@1|root,arCOG10514@2157|Archaea,41STR@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_189923_1 231434.JQJH01000002_gene2635 5.1e-85 265.0 COG4992@1|root,COG4992@2|Bacteria,1R6U9@1224|Proteobacteria,2TUDK@28211|Alphaproteobacteria,3NAQX@45404|Beijerinckiaceae 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family MA20_16020 - 2.6.1.13 ko:K00819 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R00667 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_101228_2 290398.Csal_1542 1.43e-19 88.2 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1XK5V@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_302537_1 1279009.ADICEAN_04130 0.000244 50.8 COG1033@1|root,COG1033@2|Bacteria,4NE0M@976|Bacteroidetes,47JQA@768503|Cytophagia 976|Bacteroidetes S COGs COG1033 exporter of the RND superfamily protein - - - ko:K07003 - - - - ko00000 - - - MMPL k59_769004_2 330214.NIDE3821 1.61e-19 88.6 COG0836@1|root,COG0836@2|Bacteria 2|Bacteria M mannose-1-phosphate guanylyltransferase activity manC - 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_1544872_1 983917.RGE_19320 2.77e-08 60.5 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2VP3I@28216|Betaproteobacteria,1KMPD@119065|unclassified Burkholderiales 28216|Betaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1513259_1 1379281.AVAG01000011_gene1297 1.74e-09 61.6 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42MZJ@68525|delta/epsilon subdivisions,2WJK1@28221|Deltaproteobacteria,2M804@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Aldehyde ferredoxin oxidoreductase aorA - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_1513259_2 635013.TherJR_2229 7.17e-29 118.0 COG0303@1|root,COG0303@2|Bacteria,1TQJ8@1239|Firmicutes,248WP@186801|Clostridia,2613I@186807|Peptococcaceae 186801|Clostridia H MoeA N-terminal region (domain I and II) moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_18388_1 765912.Thimo_1242 2.22e-68 224.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1WXC2@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_302555_2 1049564.TevJSym_ac01240 1.52e-55 182.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1J51G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - iEcSMS35_1347.EcSMS35_2767 NAD_kinase k59_1138102_1 1266925.JHVX01000005_gene1982 2.94e-13 67.8 COG1187@1|root,COG1187@2|Bacteria,1MXQE@1224|Proteobacteria,2VI7P@28216|Betaproteobacteria,372Q0@32003|Nitrosomonadales 28216|Betaproteobacteria J Belongs to the pseudouridine synthase RsuA family rluF - 5.4.99.21 ko:K06182 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1138102_2 344747.PM8797T_12503 5.43e-35 132.0 COG0129@1|root,COG0129@2|Bacteria,2IWXV@203682|Planctomycetes 203682|Planctomycetes H Belongs to the IlvD Edd family ilvD GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_769029_1 1121937.AUHJ01000001_gene617 2.67e-55 193.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,4668R@72275|Alteromonadaceae 1236|Gammaproteobacteria G PQQ enzyme repeat - - - - - - - - - - - - PQQ,PQQ_2 k59_1513277_1 765913.ThidrDRAFT_1256 5.05e-72 239.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1182891_1 1049564.TevJSym_aw00630 2.84e-28 115.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J4C2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain ykoW - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_302564_1 999423.HMPREF9161_01585 3.4e-39 136.0 COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,4H2UG@909932|Negativicutes 909932|Negativicutes F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_302564_2 156889.Mmc1_0867 5.81e-36 133.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria 28211|Alphaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_459938_1 1335757.SPICUR_07610 4.67e-56 186.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales 135613|Chromatiales D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_459938_2 395493.BegalDRAFT_2908 4.09e-75 236.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,46072@72273|Thiotrichales 72273|Thiotrichales D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_18395_1 391625.PPSIR1_29398 2.5e-49 175.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,42M5P@68525|delta/epsilon subdivisions,2WIW8@28221|Deltaproteobacteria,2YUB7@29|Myxococcales 28221|Deltaproteobacteria KL Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_459939_1 161528.ED21_28208 1.7e-32 125.0 COG0530@1|root,COG0530@2|Bacteria,1PW8G@1224|Proteobacteria,2U168@28211|Alphaproteobacteria,2K6W2@204457|Sphingomonadales 204457|Sphingomonadales P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_1603457_1 1449076.JOOE01000001_gene3030 8.29e-60 194.0 COG0500@1|root,COG2226@2|Bacteria,1PNZA@1224|Proteobacteria,2V1IN@28211|Alphaproteobacteria,2KBM8@204457|Sphingomonadales 204457|Sphingomonadales Q Methyltransferase small domain - - - - - - - - - - - - - k59_1339106_1 436308.Nmar_0746 6.04e-134 383.0 COG2107@1|root,arCOG00654@2157|Archaea,41SB8@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnD - - ko:K11785 ko00130,ko01110,map00130,map01110 - R08589 RC02330 ko00000,ko00001,ko01000 - - - VitK2_biosynth k59_1086123_1 526222.Desal_0571 4.42e-29 117.0 COG0458@1|root,COG0458@2|Bacteria,1RFH4@1224|Proteobacteria,42NQ6@68525|delta/epsilon subdivisions,2WMDW@28221|Deltaproteobacteria,2M8P6@213115|Desulfovibrionales 28221|Deltaproteobacteria EF ATP-grasp domain - - - - - - - - - - - - ATP-grasp_3,ATP-grasp_4,GARS_A k59_769050_1 436308.Nmar_0041 2.94e-88 268.0 COG0083@1|root,arCOG01027@2157|Archaea,41S89@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate thrB - 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_1147060_1 272631.ML0852 2.92e-24 102.0 COG0196@1|root,COG0196@2|Bacteria,2GKQF@201174|Actinobacteria,2335U@1762|Mycobacteriaceae 201174|Actinobacteria H Belongs to the ribF family ribF GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_1552808_1 935948.KE386494_gene471 2.58e-08 54.3 COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,42F5Y@68295|Thermoanaerobacterales 186801|Clostridia E Belongs to the cysteine synthase cystathionine beta- synthase family - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1552808_2 330214.NIDE1820 1.31e-94 283.0 COG0476@1|root,COG0476@2|Bacteria,3J0WD@40117|Nitrospirae 40117|Nitrospirae H ThiF family - - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_254347_1 95619.PM1_0206665 1.26e-21 92.8 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_254347_2 1026882.MAMP_03108 3.28e-31 120.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,46048@72273|Thiotrichales 72273|Thiotrichales D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_254349_1 56780.SYN_02850 6.58e-27 106.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,42M46@68525|delta/epsilon subdivisions,2WJ7G@28221|Deltaproteobacteria,2MQCF@213462|Syntrophobacterales 28221|Deltaproteobacteria F Catalyzes the conversion of dihydroorotate to orotate pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 ko:K00254,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01868,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_254349_2 877411.JMMA01000002_gene742 2.25e-24 100.0 COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia,3WGW1@541000|Ruminococcaceae 186801|Clostridia C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) pyrK - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_310191_1 1304872.JAGC01000003_gene2361 2.37e-119 354.0 28HK0@1|root,2Z7V0@2|Bacteria,1MXSJ@1224|Proteobacteria,42P6V@68525|delta/epsilon subdivisions,2WM6M@28221|Deltaproteobacteria,2MEQU@213115|Desulfovibrionales 28221|Deltaproteobacteria S Domain of unknown function (DUF4105) - - - - - - - - - - - - DUF4105 k59_1460388_1 1131269.AQVV01000004_gene599 3.24e-24 103.0 COG3225@1|root,COG3225@2|Bacteria 2|Bacteria - - gldG - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC_transp_aux k59_937331_1 1232683.ADIMK_2146 2.11e-102 313.0 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,464SD@72275|Alteromonadaceae 1236|Gammaproteobacteria O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_1253378_1 744980.TRICHSKD4_0170 3.59e-38 139.0 COG1476@1|root,COG1476@2|Bacteria,1NQ7T@1224|Proteobacteria,2TUQU@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional - - - - - - - - - - - - HTH_3 k59_1401814_1 998088.B565_2361 1.12e-30 124.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1Y3MV@135624|Aeromonadales 135624|Aeromonadales F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_1401840_1 743525.TSC_c19060 2.32e-22 95.5 COG1926@1|root,COG1926@2|Bacteria,1WJGC@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S PFAM Phosphoribosyl transferase domain - - - - - - - - - - - - Pribosyltran k59_1191947_1 1121921.KB898711_gene1998 7.3e-18 84.7 COG0421@1|root,COG0421@2|Bacteria,1QWZZ@1224|Proteobacteria,1T31M@1236|Gammaproteobacteria,2PNTX@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - Methyltransf_25 k59_469187_1 1123504.JQKD01000045_gene2105 2.38e-49 176.0 COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VI39@28216|Betaproteobacteria,4AJ2P@80864|Comamonadaceae 28216|Betaproteobacteria EH Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1462129_1 999141.GME_17788 2.39e-84 273.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1XHJR@135619|Oceanospirillales 135619|Oceanospirillales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_363512_1 1168067.JAGP01000001_gene790 3.48e-46 158.0 COG1893@1|root,COG1893@2|Bacteria,1R60C@1224|Proteobacteria,1RZQZ@1236|Gammaproteobacteria,460EC@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - - - - - - - - - - - k59_568622_1 1123229.AUBC01000004_gene3242 1.99e-80 256.0 COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,1MVN2@1224|Proteobacteria,2TUT9@28211|Alphaproteobacteria 28211|Alphaproteobacteria HJ Cyanophycin synthetase cphA - - - - - - - - - - - Acetyltransf_1,Dala_Dala_lig_C,GSH-S_ATP,RimK k59_1038555_1 648885.KB316283_gene3986 4.69e-95 300.0 COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,2TVN2@28211|Alphaproteobacteria,1JQTS@119045|Methylobacteriaceae 28211|Alphaproteobacteria HP MoeA domain protein domain I and II MA20_10225 - 2.10.1.1 ko:K03750,ko:K07219 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N,PBP_like k59_363528_1 1121878.AUGL01000015_gene3124 5.64e-28 112.0 COG0845@1|root,COG0845@2|Bacteria,1MV1T@1224|Proteobacteria,1RQTS@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3,HlyD_D23 k59_1038561_2 323261.Noc_0187 3.43e-80 243.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1S23B@1236|Gammaproteobacteria,1WW1Q@135613|Chromatiales 135613|Chromatiales S Belongs to the WrbA family - - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_1148853_1 768671.ThimaDRAFT_4338 3.87e-22 97.8 COG2035@1|root,COG2035@2|Bacteria,1MXVI@1224|Proteobacteria,1RN4B@1236|Gammaproteobacteria,1WYST@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF368) - - - ko:K08974 - - - - ko00000 - - - DUF368 k59_155548_1 357808.RoseRS_2735 2.97e-119 373.0 COG3408@1|root,COG3408@2|Bacteria,2G7KB@200795|Chloroflexi,376HX@32061|Chloroflexia 32061|Chloroflexia G Bacterial alpha-L-rhamnosidase C-terminal domain - - 3.2.1.40 ko:K05989 - - - - ko00000,ko01000 - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N k59_622114_1 1437824.BN940_17886 5.77e-68 225.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,3T1EM@506|Alcaligenaceae 28216|Betaproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_568645_1 1238182.C882_0185 1.27e-38 141.0 COG3221@1|root,COG3221@2|Bacteria,1MWFF@1224|Proteobacteria,2TUB4@28211|Alphaproteobacteria,2JQT4@204441|Rhodospirillales 204441|Rhodospirillales P ABC-type phosphate phosphonate transport system periplasmic component - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_1403550_1 1237149.C900_04556 5.68e-22 94.0 COG1398@1|root,COG1398@2|Bacteria,4NJI9@976|Bacteroidetes,47XKP@768503|Cytophagia 976|Bacteroidetes I Fatty acid desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_1403550_2 1226994.AMZB01000125_gene3105 3.26e-35 135.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1YEA1@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_469234_1 243231.GSU2333 6.99e-131 402.0 COG1615@1|root,COG1615@2|Bacteria,1MZ5A@1224|Proteobacteria,42M4M@68525|delta/epsilon subdivisions,2WIPI@28221|Deltaproteobacteria,43SU8@69541|Desulfuromonadales 28221|Deltaproteobacteria S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 k59_985774_1 1313172.YM304_26210 5.96e-95 300.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria,4CMW5@84992|Acidimicrobiia 201174|Actinobacteria CJ CoA binding domain acdA1 - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_985780_1 713586.KB900536_gene1841 5.41e-60 207.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_469243_1 1156844.KB891812_gene5070 1.66e-19 94.7 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,2GPPN@201174|Actinobacteria 201174|Actinobacteria P Chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC k59_1348244_1 1283300.ATXB01000001_gene1548 7.2e-84 262.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1XDR2@135618|Methylococcales 135618|Methylococcales J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_882227_1 1132509.C447_11030 1.45e-15 81.3 COG3119@1|root,arCOG02785@2157|Archaea,2XUB1@28890|Euryarchaeota,23TRP@183963|Halobacteria 183963|Halobacteria P COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - Sulfatase k59_938961_1 237368.SCABRO_03364 1.42e-107 324.0 COG1226@1|root,COG1226@2|Bacteria,2IYAZ@203682|Planctomycetes 203682|Planctomycetes P K transport systems - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_C,TrkA_N k59_155612_1 444878.E3SR98_9CAUD 3.24e-66 208.0 4QGVD@10239|Viruses,4R0HF@35237|dsDNA viruses no RNA stage,4QSSC@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_155612_2 118173.KB235914_gene2048 4.56e-15 72.4 COG4990@1|root,COG4990@2|Bacteria,1G79T@1117|Cyanobacteria,1HBY3@1150|Oscillatoriales 1117|Cyanobacteria S Papain-like cysteine protease AvrRpt2 - - - - - - - - - - - - Peptidase_C39_2 k59_1348281_1 640510.BC1001_5789 1.65e-70 223.0 COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2VU72@28216|Betaproteobacteria,1K5Y9@119060|Burkholderiaceae 28216|Betaproteobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1348281_2 1238182.C882_4243 4.26e-09 57.4 COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria,2UA1Z@28211|Alphaproteobacteria,2JTQA@204441|Rhodospirillales 204441|Rhodospirillales P NADH-ubiquinone/plastoquinone oxidoreductase chain 4L - - - ko:K05567 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Oxidored_q2 k59_255707_1 644968.DFW101_2840 1.73e-14 78.2 COG1032@1|root,COG1032@2|Bacteria,1MUMS@1224|Proteobacteria,42QFG@68525|delta/epsilon subdivisions,2WK91@28221|Deltaproteobacteria,2MGCW@213115|Desulfovibrionales 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,Radical_SAM k59_255707_2 880072.Desac_0929 3.96e-18 84.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42N93@68525|delta/epsilon subdivisions,2WJ9N@28221|Deltaproteobacteria,2MQI5@213462|Syntrophobacterales 28221|Deltaproteobacteria P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC k59_985836_1 754477.Q7C_490 3.58e-67 224.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_776851_1 887325.HMPREF0381_2130 1.35e-45 162.0 COG1488@1|root,COG1488@2|Bacteria,1TPDW@1239|Firmicutes,247NY@186801|Clostridia,1HUGC@1164882|Lachnoanaerobaculum 186801|Clostridia F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP pncB - 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - - NAPRTase,QRPTase_C,QRPTase_N k59_155646_1 330214.NIDE0609 3.07e-51 182.0 COG3383@1|root,COG3383@2|Bacteria,3J0UR@40117|Nitrospirae 40117|Nitrospirae C Molydopterin dinucleotide binding domain - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdopterin,Molydop_binding k59_200164_2 768671.ThimaDRAFT_3757 8.33e-40 146.0 COG0421@1|root,COG0421@2|Bacteria,1QZ2Z@1224|Proteobacteria 1224|Proteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - - k59_939015_1 391615.ABSJ01000022_gene309 1.82e-196 576.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J4C2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain ykoW - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_1554631_1 580332.Slit_2120 6.79e-14 80.1 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,44VR7@713636|Nitrosomonadales 28216|Betaproteobacteria NU pilus assembly protein FimV fimV - - ko:K08086 - - - - ko00000 - - - LysM k59_939020_1 382464.ABSI01000014_gene1483 2.47e-77 245.0 COG1538@1|root,COG1538@2|Bacteria,46WHQ@74201|Verrucomicrobia,2IW13@203494|Verrucomicrobiae 203494|Verrucomicrobiae MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1403679_1 1288494.EBAPG3_29850 8.26e-25 95.5 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2VSE6@28216|Betaproteobacteria,3737M@32003|Nitrosomonadales 28216|Betaproteobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_1403679_2 631362.Thi970DRAFT_01961 3.35e-50 160.0 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,1S5VT@1236|Gammaproteobacteria,1WYHJ@135613|Chromatiales 135613|Chromatiales J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_1403679_3 225849.swp_2014 3.43e-36 129.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,2QAWI@267890|Shewanellaceae 1236|Gammaproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_939026_1 1249627.D779_4223 1.33e-91 277.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RQJD@1236|Gammaproteobacteria,1WWK0@135613|Chromatiales 135613|Chromatiales K LysR family - - - ko:K21703 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_882293_2 484018.BACPLE_02661 1.96e-34 131.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,4NHXQ@976|Bacteroidetes,2FNAT@200643|Bacteroidia,4AMHC@815|Bacteroidaceae 976|Bacteroidetes H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_727800_1 1122197.ATWI01000016_gene2164 6.77e-38 136.0 COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,1T63B@1236|Gammaproteobacteria,46DFC@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the CDS family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_1554665_1 1123386.AUIW01000005_gene1456 0.000192 43.5 COG0843@1|root,COG0843@2|Bacteria,1WMEA@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Cytochrome C and Quinol oxidase polypeptide I - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_1554665_2 1244869.H261_01552 1.81e-73 224.0 COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,2UJSY@28211|Alphaproteobacteria 28211|Alphaproteobacteria C cytochrome c oxidase (Subunit II) - - - - - - - - - - - - - k59_255769_1 177439.DP2581 1.82e-34 134.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MISJ@213118|Desulfobacterales 28221|Deltaproteobacteria J ribonuclease Rne Rng family cafA - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_727813_1 160488.PP_2270 1.49e-67 224.0 COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria,1QWI1@1224|Proteobacteria,1RZ7K@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Toprim-like - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,DnaB_C,Toprim_2 k59_1204513_1 1127673.GLIP_3893 2.63e-65 211.0 COG3000@1|root,COG3000@2|Bacteria,1PK2S@1224|Proteobacteria,1S338@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG3000 Sterol desaturase - - - - - - - - - - - - FA_hydroxylase k59_1204513_2 1173025.GEI7407_2981 2.36e-53 176.0 COG1309@1|root,COG1309@2|Bacteria,1G5HM@1117|Cyanobacteria,1HFDU@1150|Oscillatoriales 1117|Cyanobacteria K PFAM Bacterial regulatory proteins, tetR family - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_11,TetR_C_13,TetR_C_6,TetR_N k59_368307_1 1415780.JPOG01000001_gene1538 1.81e-103 307.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1X35R@135614|Xanthomonadales 135614|Xanthomonadales EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_576981_1 700598.Niako_2094 3.72e-112 340.0 COG2220@1|root,COG2220@2|Bacteria 2|Bacteria S N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity - - 1.14.18.2 ko:K08080,ko:K14952 ko00520,ko05152,map00520,map05152 - R01115,R01803 RC00157 ko00000,ko00001,ko01000 - - - Lactamase_B_3,Rieske k59_211478_1 1282876.BAOK01000001_gene3321 4.22e-82 263.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_995301_2 754059.M1Q7A7_9CAUD 1.38e-48 157.0 4QBN5@10239|Viruses,4R0D8@35237|dsDNA viruses no RNA stage,4QQX3@28883|Caudovirales,4QNF3@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_1413277_1 745014.OMB55_00007370 2.17e-67 216.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,1RPZ9@1236|Gammaproteobacteria,1J7GJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_56195_1 1210884.HG799464_gene10612 1.26e-05 48.9 COG0515@1|root,COG0515@2|Bacteria,2IXDF@203682|Planctomycetes 203682|Planctomycetes KLT Protein kinase domain - - 2.7.11.1 ko:K08884 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_56195_2 1123261.AXDW01000001_gene1372 4.31e-19 86.3 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,1RQUV@1236|Gammaproteobacteria,1X4AA@135614|Xanthomonadales 135614|Xanthomonadales T phosphatase - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 k59_1622556_1 1340493.JNIF01000003_gene3089 1.1e-24 104.0 COG4783@1|root,COG4783@2|Bacteria 2|Bacteria L chaperone-mediated protein folding bepA GO:0003674,GO:0003756,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016787,GO:0016853,GO:0016860,GO:0016864,GO:0019538,GO:0022607,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043163,GO:0043165,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0045229,GO:0046872,GO:0051603,GO:0061024,GO:0061077,GO:0070011,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - Peptidase_M48,TPR_19 k59_839041_1 1236959.BAMT01000001_gene1719 2.04e-78 243.0 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,2VJWH@28216|Betaproteobacteria,2KMET@206350|Nitrosomonadales 206350|Nitrosomonadales P Inositol monophosphatase family - - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_1308780_1 1121929.KB898666_gene2565 4.81e-71 230.0 COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,4HBIM@91061|Bacilli 91061|Bacilli G ABC transporter (Permease sugA_2 - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_1308780_2 1144275.COCOR_00137 5.37e-28 114.0 COG1653@1|root,COG1653@2|Bacteria,1MX9J@1224|Proteobacteria,42RW7@68525|delta/epsilon subdivisions,2WNE4@28221|Deltaproteobacteria,2YUMC@29|Myxococcales 28221|Deltaproteobacteria G Bacterial extracellular solute-binding protein - - - ko:K02027,ko:K10236 ko02010,map02010 M00204,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.17 - - SBP_bac_1,SBP_bac_8 k59_839047_2 794903.OPIT5_05425 2.19e-13 70.5 COG2334@1|root,COG2334@2|Bacteria,46TIS@74201|Verrucomicrobia 74201|Verrucomicrobia S Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_1205388_1 436308.Nmar_1760 6.5e-54 172.0 COG2453@1|root,arCOG03413@2157|Archaea,41SK5@651137|Thaumarchaeota 651137|Thaumarchaeota T Dual specificity phosphatase, catalytic domain - - 3.1.3.16,3.1.3.48 ko:K14165 - - - - ko00000,ko01000,ko01009 - - - DSPc k59_1205388_2 436308.Nmar_0217 5.59e-19 84.7 COG1180@1|root,arCOG00946@2157|Archaea,41SBZ@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Radical_SAM k59_421154_1 1085623.GNIT_0106 2.52e-49 175.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,1RPFW@1236|Gammaproteobacteria,465DX@72275|Alteromonadaceae 1236|Gammaproteobacteria I Carboxylesterase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_995323_1 448385.sce5871 6.68e-173 521.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,2YX1T@29|Myxococcales 28221|Deltaproteobacteria H Methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_56219_1 402881.Plav_1766 5.59e-47 169.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,1JNSZ@119043|Rhodobiaceae 28211|Alphaproteobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K04116 ko00362,ko01120,map00362,map01120 M00540 R05620 RC00004,RC01438 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C k59_1152190_1 649638.Trad_0128 9.58e-103 313.0 COG3333@1|root,COG3333@2|Bacteria,1WIRN@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S PFAM Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_839059_1 396588.Tgr7_0894 1.95e-38 142.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1WX8Q@135613|Chromatiales 135613|Chromatiales M Cell wall hydrolase autolysin - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,LysM k59_839059_2 745411.B3C1_17987 3.41e-06 47.8 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1J50B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_1100333_1 436308.Nmar_1129 7.25e-21 94.4 COG3794@1|root,arCOG02926@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind k59_630862_1 335543.Sfum_3646 3.66e-33 119.0 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,42VN5@68525|delta/epsilon subdivisions,2WRGG@28221|Deltaproteobacteria,2MQM6@213462|Syntrophobacterales 28221|Deltaproteobacteria J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_891431_1 1121396.KB893080_gene898 4.7e-84 268.0 COG0642@1|root,COG2205@2|Bacteria,1QUJ7@1224|Proteobacteria,43BJF@68525|delta/epsilon subdivisions,2WU4G@28221|Deltaproteobacteria,2MMQM@213118|Desulfobacterales 28221|Deltaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA k59_683056_1 1229909.NSED_02560 2.73e-90 277.0 COG0373@1|root,arCOG01036@2157|Archaea,41SDM@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) - - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_787498_1 1198232.CYCME_1787 1.49e-17 76.3 COG2212@1|root,COG2212@2|Bacteria,1N6VV@1224|Proteobacteria,1SE40@1236|Gammaproteobacteria,462U9@72273|Thiotrichales 72273|Thiotrichales P Multiple resistance and pH regulation protein F (MrpF / PhaF) - - - ko:K05570 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MrpF_PhaF k59_787498_2 1198232.CYCME_1786 1.5e-45 149.0 COG1320@1|root,COG1320@2|Bacteria,1PC9X@1224|Proteobacteria,1SX6D@1236|Gammaproteobacteria,4630V@72273|Thiotrichales 72273|Thiotrichales P Na+/H+ antiporter subunit - - - ko:K05571 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - PhaG_MnhG_YufB k59_787498_3 1198232.CYCME_1785 6.32e-85 256.0 COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,1RR3K@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Na H antiporter, MnhB - - - ko:K05566 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040,MnhB k59_316899_1 1201290.M902_0273 5.39e-09 61.2 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,42QPE@68525|delta/epsilon subdivisions,2WRND@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_264512_1 34506.g6040 1.18e-79 267.0 COG0642@1|root,COG1025@1|root,COG5641@1|root,KOG0519@2759|Eukaryota,KOG0959@2759|Eukaryota,KOG1601@2759|Eukaryota,3AGK5@33154|Opisthokonta,3BXQF@33208|Metazoa,3DDEZ@33213|Bilateria 33208|Metazoa K Sigma-54 interaction domain - - - - - - - - - - - - Response_reg,Sigma54_activat k59_1466078_1 349124.Hhal_1683 9.07e-13 70.1 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1WWPS@135613|Chromatiales 135613|Chromatiales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_995352_1 396588.Tgr7_1512 2.57e-114 337.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,1RVJU@1236|Gammaproteobacteria,1WXJS@135613|Chromatiales 135613|Chromatiales I Poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009058,GO:0016234,GO:0042618,GO:0042619,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0070088,GO:0071704,GO:1901440,GO:1901441,GO:1901576 - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1308828_2 247634.GPB2148_3799 5.18e-36 129.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria 1224|Proteobacteria NT Methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,CZB,HAMP,MCPsignal,PAS_3,PAS_9,dCache_1 k59_734597_1 1123073.KB899241_gene1855 1.88e-85 262.0 COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,1X3CD@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_1622610_1 1122604.JONR01000018_gene1089 1.28e-76 244.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1X3ZZ@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,Pribosyltran k59_734598_1 1173024.KI912152_gene425 7.63e-70 228.0 COG5659@1|root,COG5659@2|Bacteria,1GDXT@1117|Cyanobacteria 1117|Cyanobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_5 k59_995355_1 338966.Ppro_1343 1.27e-37 146.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,43SYQ@69541|Desulfuromonadales 28221|Deltaproteobacteria H Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 k59_1257614_1 367737.Abu_0314 1.03e-66 207.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,42MDJ@68525|delta/epsilon subdivisions,2YMUT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_525580_1 1288298.rosmuc_01327 1.11e-87 268.0 COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,2TRF6@28211|Alphaproteobacteria,46QHY@74030|Roseovarius 28211|Alphaproteobacteria GM Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction fcl - 1.1.1.271 ko:K02377 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R05692 RC01014 ko00000,ko00001,ko01000 - - - Epimerase k59_473001_1 1198232.CYCME_2375 2.86e-45 166.0 COG0457@1|root,COG0457@2|Bacteria,1R50I@1224|Proteobacteria,1RSP6@1236|Gammaproteobacteria,462D9@72273|Thiotrichales 72273|Thiotrichales S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1926_1 754477.Q7C_1644 2.09e-62 196.0 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,1RQ0Y@1236|Gammaproteobacteria,460SM@72273|Thiotrichales 72273|Thiotrichales Q MlaD protein mlaD - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_525581_1 502025.Hoch_6550 4.95e-15 79.7 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,42Q75@68525|delta/epsilon subdivisions,2WMDY@28221|Deltaproteobacteria,2YUG7@29|Myxococcales 28221|Deltaproteobacteria L DEAD/H associated lhr1 - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_107376_1 290397.Adeh_3964 5.64e-168 479.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,42M69@68525|delta/epsilon subdivisions,2WIYC@28221|Deltaproteobacteria,2YTSX@29|Myxococcales 28221|Deltaproteobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_107376_2 335543.Sfum_2529 1.9e-27 109.0 COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,42TMM@68525|delta/epsilon subdivisions,2WQ6S@28221|Deltaproteobacteria,2MRXS@213462|Syntrophobacterales 28221|Deltaproteobacteria J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester - - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase k59_107376_3 1499502.EV12_1659 7.51e-05 46.6 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1G0IZ@1117|Cyanobacteria,1MKFF@1212|Prochloraceae 1117|Cyanobacteria S Belongs to the CinA family cinA - 3.5.1.42 ko:K03742 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth k59_839094_1 643473.KB235930_gene706 5.11e-12 65.1 COG3957@1|root,COG3957@2|Bacteria,1G0B2@1117|Cyanobacteria,1HKKE@1161|Nostocales 1117|Cyanobacteria G D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase - - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_839094_2 41431.PCC8801_3370 8.72e-47 162.0 COG1085@1|root,COG1085@2|Bacteria,1G1CA@1117|Cyanobacteria,3KH77@43988|Cyanothece 1117|Cyanobacteria H galactose-1-phosphate uridyl transferase domain protein - - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GalP_UDP_tr_C,GalP_UDP_transf,HIT k59_1048025_1 1229909.NSED_01015 4.45e-28 107.0 COG1573@1|root,arCOG00905@2157|Archaea 2157|Archaea L Uracil-DNA glycosylase - GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_264535_1 243233.MCA3051 8.23e-110 323.0 COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,1RMS7@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Phosphoribulokinase prkB GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.19 ko:K00855 ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200 M00165,M00166 R01523 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PRK k59_1048033_1 743720.Psefu_4193 1.72e-58 202.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1YWJ9@136845|Pseudomonas putida group 1236|Gammaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0339 Transketolase_N k59_1205470_1 519989.ECTPHS_05325 1.32e-131 383.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1WW43@135613|Chromatiales 135613|Chromatiales J TIGRFAM Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_1205472_1 743722.Sph21_3143 4.94e-134 389.0 COG0158@1|root,COG0158@2|Bacteria,4NG06@976|Bacteroidetes,1IQAD@117747|Sphingobacteriia 976|Bacteroidetes G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 fbp - 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase k59_212239_1 391615.ABSJ01000026_gene114 8.09e-48 162.0 COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,1S50X@1236|Gammaproteobacteria,1J761@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Inner membrane component of T3SS, cytoplasmic domain - - - - - - - - - - - - FHA,Yop-YscD_cpl k59_734625_1 469610.HMPREF0189_00099 0.000986 39.7 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,2VSGE@28216|Betaproteobacteria,1KM4Y@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_734625_2 882.DVU_1306 4.52e-107 316.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,42MBV@68525|delta/epsilon subdivisions,2WIRE@28221|Deltaproteobacteria,2M8B7@213115|Desulfovibrionales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_995377_1 62928.azo2150 4.85e-12 63.9 COG0824@1|root,COG0824@2|Bacteria,1MZTU@1224|Proteobacteria,2VSY8@28216|Betaproteobacteria,2M03S@206389|Rhodocyclales 206389|Rhodocyclales S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT_2 k59_995377_2 1125863.JAFN01000001_gene1710 3.31e-176 505.0 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,42PC9@68525|delta/epsilon subdivisions,2WKA4@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Na dependent nucleoside transporter - - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_56318_1 458233.MCCL_0901 5.64e-08 59.7 COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,4HEI7@91061|Bacilli,4GZFG@90964|Staphylococcaceae 91061|Bacilli L Phage integrase family - - - - - - - - - - - - Arm-DNA-bind_4,Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase k59_787565_1 1120956.JHZK01000003_gene421 3.32e-37 129.0 COG2164@1|root,COG2164@2|Bacteria,1N81P@1224|Proteobacteria,2UF42@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Cyclophilin-like - - - ko:K09143 - - - - ko00000 - - - Cyclophil_like k59_683124_1 713586.KB900536_gene1412 1.67e-42 149.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1WXKK@135613|Chromatiales 135613|Chromatiales P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_683124_2 187272.Mlg_2225 4.86e-93 282.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1WWFJ@135613|Chromatiales 135613|Chromatiales M Arabinose 5-phosphate isomerase - - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_1361511_2 658187.LDG_5263 1.51e-06 53.1 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1JD0N@118969|Legionellales 118969|Legionellales J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_107414_1 1283300.ATXB01000002_gene2574 2.85e-40 142.0 292MF@1|root,2ZQ5C@2|Bacteria,1RCYR@1224|Proteobacteria,1S44V@1236|Gammaproteobacteria,1XF22@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF3047) - - - - - - - - - - - - DUF3047 k59_683127_1 1388763.O165_028660 5.59e-08 55.5 COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,1RS3S@1236|Gammaproteobacteria,1YWRP@136845|Pseudomonas putida group 1236|Gammaproteobacteria HL Nudix hydrolase mutT GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008413,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017110,GO:0030145,GO:0033554,GO:0034641,GO:0035539,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044715,GO:0044716,GO:0046483,GO:0046872,GO:0046914,GO:0047429,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - iE2348C_1286.E2348C_0104,iSDY_1059.SDY_0129 NUDIX,NUDIX_4,TMP-TENI k59_683127_2 398767.Glov_3188 3.41e-37 136.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,42MDN@68525|delta/epsilon subdivisions,2WINX@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1466133_1 1120949.KB903339_gene7896 9.34e-14 78.6 COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,2GQ7E@201174|Actinobacteria,4DHR8@85008|Micromonosporales 201174|Actinobacteria P Copper resistance protein D - - - ko:K14166 - - - - ko00000,ko02000 - - - CopC,CopD k59_734642_1 1128421.JAGA01000003_gene3541 7.3e-23 107.0 COG1649@1|root,COG3391@1|root,COG1649@2|Bacteria,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity MA20_20600 - 1.14.17.3,2.7.11.1 ko:K00504,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - GHL10,NHL,Pkinase,SGL k59_577820_1 240015.ACP_0895 1.03e-54 181.0 COG4181@1|root,COG4181@2|Bacteria,3Y3RU@57723|Acidobacteria,2JI42@204432|Acidobacteriia 204432|Acidobacteriia Q ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_369088_1 55601.VANGNB10_cI1280 8.03e-46 157.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,1XTQ4@135623|Vibrionales 135623|Vibrionales J Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system ttcA - - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_369088_2 296591.Bpro_3376 4.74e-18 83.6 COG0388@1|root,COG0388@2|Bacteria,1MWQG@1224|Proteobacteria,2VRMQ@28216|Betaproteobacteria,4AEQZ@80864|Comamonadaceae 28216|Betaproteobacteria S Carbon-nitrogen hydrolase nit2 - 3.5.5.1 ko:K01501 ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120 - R00540,R01887,R03093,R03542,R05591,R07855 RC00315,RC00325,RC00617,RC00959,RC02811 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_1048070_1 279383.Q5DN21_9CAUD 7.75e-20 94.7 4QBTT@10239|Viruses,4QVNB@35237|dsDNA viruses no RNA stage,4QQUU@28883|Caudovirales,4QKWB@10699|Siphoviridae 10699|Siphoviridae S Phage conserved hypothetical protein BR0599 - - - - - - - - - - - - - k59_1263246_2 1229909.NSED_06300 3.63e-25 96.3 arCOG10573@1|root,arCOG10573@2157|Archaea,41T8W@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1052492_1 391615.ABSJ01000032_gene712 8.44e-25 102.0 COG2242@1|root,COG2242@2|Bacteria,1R79F@1224|Proteobacteria,1RY3Z@1236|Gammaproteobacteria,1J8AJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H protein methyltransferase activity - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_1052492_2 1254432.SCE1572_25395 3.95e-30 119.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,2YX1T@29|Myxococcales 28221|Deltaproteobacteria H Methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_216531_3 402881.Plav_0280 1.68e-42 145.0 COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,2VAZC@28211|Alphaproteobacteria,1JQKQ@119043|Rhodobiaceae 28211|Alphaproteobacteria E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase k59_688501_1 153721.MYP_2010 1.11e-11 62.4 COG2818@1|root,COG2818@2|Bacteria,4NGRC@976|Bacteroidetes,47PXB@768503|Cytophagia 976|Bacteroidetes L PFAM methyladenine glycosylase tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_373255_1 385682.AFSL01000023_gene2122 4.02e-43 160.0 COG0427@1|root,COG0427@2|Bacteria,4NFS3@976|Bacteroidetes,2FNCA@200643|Bacteroidia,3XJ98@558415|Marinilabiliaceae 976|Bacteroidetes C Acetyl-CoA hydrolase/transferase C-terminal domain - - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_61987_1 436308.Nmar_1782 1.74e-119 354.0 COG1746@1|root,arCOG04249@2157|Archaea,41S76@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate cca - 2.7.7.72 ko:K07558 - - R09382,R09383,R09384,R09386 RC00078 ko00000,ko01000,ko03016 - - - NTP_transf_2,tRNA_NucTransf2 k59_111415_1 207954.MED92_02264 3.56e-65 206.0 arCOG03638@1|root,2Z7NN@2|Bacteria,1R3Y6@1224|Proteobacteria,1RTWY@1236|Gammaproteobacteria,1XIZW@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_477573_1 335543.Sfum_2673 2.56e-48 165.0 COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,42Q81@68525|delta/epsilon subdivisions,2WIJ3@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TRAP transporter T-component - - - - - - - - - - - - TAtT k59_1519956_2 167555.NATL1_16721 4.64e-24 99.0 COG3510@1|root,COG3510@2|Bacteria 2|Bacteria V cephalosporin hydroxylase - - - - - - - - - - - - CmcI,Methyltransf_24 k59_1417922_1 1229909.NSED_08360 1.25e-15 73.9 arCOG10589@1|root,arCOG10589@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1417922_2 436308.Nmar_1520 7.17e-28 102.0 arCOG10588@1|root,arCOG10588@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1417922_3 1229909.NSED_08350 9.76e-43 143.0 COG2101@1|root,arCOG01764@2157|Archaea,41SZD@651137|Thaumarchaeota 651137|Thaumarchaeota K General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation - - - ko:K03120 ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203 - - - ko00000,ko00001,ko03000,ko03021 - - - TBP k59_477580_1 1283300.ATXB01000001_gene1783 9.05e-47 162.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1T1HN@1236|Gammaproteobacteria,1XDWI@135618|Methylococcales 135618|Methylococcales V pfam abc - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1574132_1 861299.J421_1151 1.49e-14 72.8 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1ZTCF@142182|Gemmatimonadetes 142182|Gemmatimonadetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1471355_2 2340.JV46_21410 5.1e-68 211.0 COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,1S263@1236|Gammaproteobacteria,1J666@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0032843,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - Redoxin k59_425582_1 1207058.L53_14250 1.02e-23 99.4 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TU1G@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1062 Zn-dependent alcohol dehydrogenases, class III MA20_19250 - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_895877_1 323261.Noc_2021 9.82e-48 172.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,Response_reg k59_1626926_1 377629.TERTU_0035 1.58e-65 217.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,2PMQ1@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria JK 16S rRNA methyltransferase RsmB/F sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_162280_2 110662.Syncc9605_0346 2.59e-36 130.0 COG1403@1|root,COG1403@2|Bacteria,1G180@1117|Cyanobacteria,1GYQG@1129|Synechococcus 1117|Cyanobacteria L HNH endonuclease mcrA - - - - - - - - - - - HNH,HNH_5 k59_843486_2 706587.Desti_3855 1.72e-81 251.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2WJMN@28221|Deltaproteobacteria,2MQB2@213462|Syntrophobacterales 28221|Deltaproteobacteria J TIGRFAM methionine aminopeptidase, type I map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_582051_1 754059.M1NXQ9_9CAUD 1.5e-65 205.0 4QAUS@10239|Viruses,4QURX@35237|dsDNA viruses no RNA stage,4QQ2S@28883|Caudovirales 28883|Caudovirales S flavin adenine dinucleotide binding - - - - - - - - - - - - - k59_1211186_1 1122134.KB893650_gene215 4.4e-39 139.0 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S5Y0@1236|Gammaproteobacteria,1XK0E@135619|Oceanospirillales 135619|Oceanospirillales Q TRAP-type mannitol chloroaromatic compound transport system, small permease component gtrA - - - - - - - - - - - DctQ k59_636544_3 1414738.V5UPN0_9CAUD 0.000169 47.4 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QNBQ@10744|Podoviridae 10744|Podoviridae S HNH endonuclease - - - - - - - - - - - - - k59_529797_2 1255043.TVNIR_2005 1.36e-30 114.0 COG3193@1|root,COG3193@2|Bacteria,1RJ3X@1224|Proteobacteria,1S8FV@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Haem-degrading - - - - - - - - - - - - Haem_degrading k59_373288_1 864702.OsccyDRAFT_2102 1.01e-61 197.0 COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria,1HAGW@1150|Oscillatoriales 1117|Cyanobacteria S Belongs to the SOS response-associated peptidase family - - - - - - - - - - - - SRAP k59_1104856_1 330214.NIDE3039 2.73e-106 313.0 COG3494@1|root,COG3494@2|Bacteria,3J0KP@40117|Nitrospirae 40117|Nitrospirae S Protein of unknown function (DUF1009) - - - ko:K09949 - - - - ko00000 - - - DUF1009 k59_1365811_1 580332.Slit_1414 6.44e-118 349.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,44VKE@713636|Nitrosomonadales 28216|Betaproteobacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_373289_2 469371.Tbis_2432 5.21e-68 221.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DXK8@85010|Pseudonocardiales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_636554_1 187272.Mlg_1899 1.22e-43 154.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1WWEM@135613|Chromatiales 135613|Chromatiales O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_582060_1 1123277.KB893195_gene5692 4.74e-20 95.1 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47JJN@768503|Cytophagia 976|Bacteroidetes V FtsX-like permease family - - - - - - - - - - - - FtsX,MacB_PCD k59_582060_2 1265503.KB905178_gene3920 1.31e-12 65.5 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,2Q7PC@267889|Colwelliaceae 1236|Gammaproteobacteria V ABC transporter lolD_1 - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1052536_2 331678.Cphamn1_1707 1.01e-30 121.0 COG0443@1|root,COG0443@2|Bacteria,1FD8N@1090|Chlorobi 1090|Chlorobi O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_529810_1 96561.Dole_2582 1.35e-81 251.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,42MP8@68525|delta/epsilon subdivisions,2WKMR@28221|Deltaproteobacteria,2MIXA@213118|Desulfobacterales 28221|Deltaproteobacteria F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_688545_1 472759.Nhal_3586 1.77e-123 374.0 COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,1X0IX@135613|Chromatiales 135613|Chromatiales S PFAM peptidase S15 - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_1052538_1 557599.MKAN_15950 7.75e-13 72.8 COG2141@1|root,COG2141@2|Bacteria,2GNQ1@201174|Actinobacteria,236II@1762|Mycobacteriaceae 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_843508_1 243233.MCA3000 7.32e-71 235.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1XDXS@135618|Methylococcales 135618|Methylococcales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_1365825_1 555779.Dthio_PD3292 3.19e-38 135.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,2M7S0@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM response regulator receiver phoB - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1211211_1 1243664.CAVL020000049_gene5125 1.1e-06 52.0 COG1309@1|root,COG1309@2|Bacteria,1V4J3@1239|Firmicutes,4HHPI@91061|Bacilli,1ZG5D@1386|Bacillus 91061|Bacilli K Transcriptional regulator yvdT_1 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - - - - - - - - - - TetR_C_4,TetR_N k59_636578_2 530564.Psta_3785 1.9e-18 90.9 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2IXQR@203682|Planctomycetes 203682|Planctomycetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_529820_1 1305737.JAFX01000001_gene212 5.09e-48 170.0 COG1228@1|root,COG1228@2|Bacteria,4NEV0@976|Bacteroidetes,47MH5@768503|Cytophagia 976|Bacteroidetes Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_216593_1 398512.JQKC01000107_gene2866 2.12e-09 57.8 COG0758@1|root,COG0758@2|Bacteria,1VNFT@1239|Firmicutes,24S79@186801|Clostridia,3WMKC@541000|Ruminococcaceae 186801|Clostridia LU Protein of unknown function (DUF2493) - - - - - - - - - - - - DUF2493 k59_636582_1 1541960.KQ78_01469 0.000105 47.4 2EEXR@1|root,338R3@2|Bacteria 2|Bacteria L NUMOD3 motif (2 copies) - - - - - - - - - - - - GIY-YIG,NUMOD3 k59_636582_2 444860.E3SJ15_9CAUD 4.42e-40 138.0 4QAQQ@10239|Viruses,4QVZX@35237|dsDNA viruses no RNA stage,4QPBX@28883|Caudovirales,4QIBM@10662|Myoviridae 10662|Myoviridae S T4-like virus tail tube protein gp19 - - - - - - - - - - - - - k59_425625_1 1380394.JADL01000003_gene4764 8.91e-68 214.0 COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2TVCS@28211|Alphaproteobacteria,2JR37@204441|Rhodospirillales 204441|Rhodospirillales S Carbon-nitrogen hydrolase - - - - - - - - - - - - CN_hydrolase k59_1313915_1 631362.Thi970DRAFT_04937 1.36e-98 301.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1WVVQ@135613|Chromatiales 135613|Chromatiales H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_1211988_2 671143.DAMO_3020 0.000154 43.9 COG1051@1|root,COG2138@1|root,COG1051@2|Bacteria,COG2138@2|Bacteria,2NPZ5@2323|unclassified Bacteria 2|Bacteria F NUDIX domain cbiX - 1.1.1.169,3.1.3.25,3.6.1.55,4.99.1.3 ko:K00077,ko:K01092,ko:K03574,ko:K03795 ko00521,ko00562,ko00770,ko00860,ko01100,ko01110,ko01120,ko04070,map00521,map00562,map00770,map00860,map01100,map01110,map01120,map04070 M00119,M00131 R01185,R01186,R01187,R02472,R05807 RC00078,RC00726,RC01012 ko00000,ko00001,ko00002,ko01000,ko03400 - - - CbiX,NUDIX k59_1472176_1 1298858.AUEL01000019_gene3260 1.86e-70 243.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc k59_478405_1 1304885.AUEY01000002_gene343 1.08e-36 133.0 COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42RFX@68525|delta/epsilon subdivisions,2WN92@28221|Deltaproteobacteria,2MJZ5@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_1520423_1 1026882.MAMP_00807 1.28e-87 273.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,45ZMM@72273|Thiotrichales 72273|Thiotrichales F TIGRFAM dihydroorotase, multifunctional complex type - - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_1366457_1 1348657.M622_04430 2.75e-07 53.9 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHT0@28216|Betaproteobacteria,2KVJQ@206389|Rhodocyclales 206389|Rhodocyclales C COG1960 Acyl-CoA dehydrogenases - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1472182_1 555778.Hneap_0621 1.33e-70 238.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WXNN@135613|Chromatiales 135613|Chromatiales F PFAM glycosyl transferase family 35 - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_794125_1 95619.PM1_0226680 5.09e-70 224.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Involved in the biosynthesis of porphyrin-containing compound yggW GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_1212007_1 671143.DAMO_3124 1.18e-47 167.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA,PAS,SpoIIE,sCache_3_2 k59_162948_1 330214.NIDE4388 2.02e-86 283.0 COG3002@1|root,COG3002@2|Bacteria,3J0VY@40117|Nitrospirae 40117|Nitrospirae S Uncharacterized protein conserved in bacteria (DUF2309) - - - ko:K09822 - - - - ko00000 - - - DUF2309 k59_896550_1 228410.NE0009 1.29e-11 69.3 COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,2VJ4P@28216|Betaproteobacteria,371ZG@32003|Nitrosomonadales 28216|Betaproteobacteria S PFAM MgtC SapB transporter - - - - - - - - - - - - DUF4010,MgtC k59_582703_1 1173024.KI912148_gene3523 1.77e-106 322.0 COG2403@1|root,COG2403@2|Bacteria,1G1FF@1117|Cyanobacteria 1117|Cyanobacteria S cyclic 2,3-diphosphoglycerate synthetase activity - - - - - - - - - - - - cobW k59_582704_1 2340.JV46_14280 1.65e-87 271.0 COG1156@1|root,COG1156@2|Bacteria,1QUQE@1224|Proteobacteria,1T210@1236|Gammaproteobacteria,1JC0C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit - - - - - - - - - - - - ATP-synt_ab k59_1520431_1 318829.MGG_04346T0 5.83e-09 61.2 COG0500@1|root,KOG1269@2759|Eukaryota,38CU5@33154|Opisthokonta,3PBRQ@4751|Fungi,3R302@4890|Ascomycota,21DEQ@147550|Sordariomycetes,41K7K@639021|Magnaporthales 4751|Fungi H Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol - - 2.1.1.41 ko:K00559 ko00100,ko01100,ko01110,ko01130,map00100,map01100,map01110,map01130 M00102 R04427,R07481 RC00003,RC01154 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Sterol_MT_C k59_322353_1 391612.CY0110_11817 1.19e-66 212.0 COG0500@1|root,COG0500@2|Bacteria 2|Bacteria Q methyltransferase activity - - 2.1.1.187,2.1.1.235,2.1.1.324 ko:K00563,ko:K13307,ko:K13330,ko:K15256 ko00523,ko01130,map00523,map01130 M00796,M00802 R06439,R07233,R08932,R11452,R11453 RC00003,RC01515,RC02262,RC03440 ko00000,ko00001,ko00002,ko01000,ko03009,ko03016 - - - Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25 k59_1000032_1 1111454.HMPREF1250_0720 5.47e-25 102.0 COG2877@1|root,COG2877@2|Bacteria,1TR2G@1239|Firmicutes,4H20D@909932|Negativicutes 909932|Negativicutes M Belongs to the KdsA family kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_1000032_2 909663.KI867151_gene3000 3.57e-24 101.0 COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,42PX0@68525|delta/epsilon subdivisions,2WJUG@28221|Deltaproteobacteria,2MQYT@213462|Syntrophobacterales 28221|Deltaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - 2.4.1.266 ko:K13693 - - - - ko00000,ko01000,ko01003 - GT81 - - k59_327156_1 1380350.JIAP01000021_gene284 2.03e-109 318.0 COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,2TZ7M@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - LZ_Tnp_IS481,rve,rve_3 k59_117333_1 380394.Lferr_0287 4.19e-40 149.0 COG2251@1|root,COG2251@2|Bacteria,1QUUG@1224|Proteobacteria,1T3FR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function(DUF2779) - - - - - - - - - - - - DUF2779 k59_694078_1 450851.PHZ_c1916 5.84e-89 275.0 COG0614@1|root,COG0614@2|Bacteria,1PK1C@1224|Proteobacteria,2TRF4@28211|Alphaproteobacteria 28211|Alphaproteobacteria P periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_69225_1 443218.AS9A_3171 3.86e-21 101.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,232HF@1762|Mycobacteriaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_800878_1 404589.Anae109_0939 2.13e-41 152.0 COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,42U99@68525|delta/epsilon subdivisions,2WQ5W@28221|Deltaproteobacteria,2YWMR@29|Myxococcales 28221|Deltaproteobacteria L ATP dependent DNA ligase domain protein - - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N k59_800878_2 502025.Hoch_3329 9.37e-29 111.0 COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria,2YWME@29|Myxococcales 28221|Deltaproteobacteria L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD ku - - ko:K10979 ko03450,map03450 - - - ko00000,ko00001,ko03400 - - - Ku k59_1216879_1 293826.Amet_3897 2.27e-23 97.1 COG3415@1|root,COG3415@2|Bacteria,1U5WP@1239|Firmicutes,24RC3@186801|Clostridia 186801|Clostridia L Homeodomain-like domain - - - - - - - - - - - - HTH_32 k59_1216879_2 329726.AM1_1240 7.45e-45 151.0 COG3415@1|root,COG3415@2|Bacteria,1GA2F@1117|Cyanobacteria 1117|Cyanobacteria L Homeodomain-like domain - - - - - - - - - - - - HTH_32 k59_800880_1 1280954.HPO_03909 2.33e-48 167.0 COG1960@1|root,COG1960@2|Bacteria,1N05C@1224|Proteobacteria,2TT9T@28211|Alphaproteobacteria,43Z8N@69657|Hyphomonadaceae 28211|Alphaproteobacteria I COG1960 Acyl-CoA dehydrogenases MA20_06725 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_643870_1 240015.ACP_3363 9.67e-47 166.0 COG0773@1|root,COG0773@2|Bacteria,3Y2M2@57723|Acidobacteria,2JIE2@204432|Acidobacteriia 204432|Acidobacteriia M Mur ligase middle domain - - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_167809_1 1173026.Glo7428_0932 2.17e-48 175.0 COG1216@1|root,COG5309@1|root,COG1216@2|Bacteria,COG5309@2|Bacteria,1G2MT@1117|Cyanobacteria 1117|Cyanobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_hydro_2_C,Glycos_transf_2 k59_379536_1 42099.EPrPV00000017488 4.38e-45 166.0 COG0722@1|root,2QPSU@2759|Eukaryota,1MEXN@121069|Pythiales 121069|Pythiales E Phospho-2-dehydro-3-deoxyheptonate aldolase. Source PGD - - - - - - - - - - - - DAHP_synth_1 k59_1478578_1 330214.NIDE4126 7.95e-89 273.0 COG0612@1|root,COG0612@2|Bacteria,3J0GS@40117|Nitrospirae 40117|Nitrospirae S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_744209_1 582744.Msip34_0493 3.05e-49 164.0 COG0842@1|root,COG0842@2|Bacteria,1MUF4@1224|Proteobacteria,2W3RW@28216|Betaproteobacteria,2KNNH@206350|Nitrosomonadales 206350|Nitrosomonadales V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_744209_2 1123368.AUIS01000009_gene2454 1.79e-60 194.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1T1HN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V ABC-type multidrug transport system ATPase component - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_117355_1 1589733.A0A0C5AAW8_9CAUD 5.98e-45 178.0 4QBUC@10239|Viruses,4QQGQ@28883|Caudovirales,4QHY3@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_485057_1 266117.Rxyl_2532 1.46e-38 139.0 COG0614@1|root,COG0614@2|Bacteria,2GYJE@201174|Actinobacteria,4CTJ1@84995|Rubrobacteria 84995|Rubrobacteria P Periplasmic binding protein - - - - - - - - - - - - Peripla_BP_2 k59_222216_1 580332.Slit_1717 3.53e-12 63.2 COG1047@1|root,COG1047@2|Bacteria,1REQ1@1224|Proteobacteria,2W324@28216|Betaproteobacteria 28216|Betaproteobacteria O Peptidyl-prolyl cis-trans - - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - - k59_222216_2 580332.Slit_1716 2.81e-60 187.0 2BK43@1|root,32EHP@2|Bacteria,1RDAC@1224|Proteobacteria,2W3NZ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_485065_1 1124983.PFLCHA0_c19340 1.35e-50 181.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1YNGT@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945 BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_1425057_1 697282.Mettu_0569 7.1e-48 172.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,1RMSH@1236|Gammaproteobacteria,1XGZE@135618|Methylococcales 135618|Methylococcales G Alpha-amylase domain - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - Alpha-amylase,Malt_amylase_C k59_1425057_2 889378.Spiaf_2040 3.76e-05 44.7 COG1523@1|root,COG1523@2|Bacteria,2J61K@203691|Spirochaetes 2|Bacteria G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_222219_1 562743.JH976436_gene2647 1.43e-05 49.7 COG1502@1|root,COG1502@2|Bacteria,1TSN8@1239|Firmicutes,4HTQH@91061|Bacilli 91061|Bacilli I Phospholipase D. Active site motifs. - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_327199_1 1391646.AVSU01000038_gene1952 8.07e-33 128.0 COG2978@1|root,COG2978@2|Bacteria,1TPDU@1239|Firmicutes,24BJ1@186801|Clostridia 186801|Clostridia H Transporter - - - ko:K12942 - - - - ko00000 - - - ABG_transport k59_644414_2 1265502.KB905992_gene76 1.01e-31 112.0 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2VXF9@28216|Betaproteobacteria,4AJBR@80864|Comamonadaceae 28216|Betaproteobacteria L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_1318272_1 1077285.AGDG01000031_gene3685 9.31e-67 214.0 COG4221@1|root,COG4221@2|Bacteria,4NGKR@976|Bacteroidetes,2FM65@200643|Bacteroidia,4AKPD@815|Bacteroidaceae 976|Bacteroidetes S COG COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) vdlC - - - - - - - - - - - adh_short k59_1425547_1 1122194.AUHU01000006_gene438 7.74e-69 220.0 COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,1RYFC@1236|Gammaproteobacteria,4666X@72275|Alteromonadaceae 1236|Gammaproteobacteria T HPP family - - - ko:K07168 - - - - ko00000 - - - HPP k59_117887_1 82995.CR62_06020 4.87e-62 208.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,401QB@613|Serratia 1236|Gammaproteobacteria F DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_380103_1 1229909.NSED_02630 7.61e-113 332.0 COG1064@1|root,arCOG01455@2157|Archaea,41SA9@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1217229_1 266748.HY04_01465 9.11e-08 59.3 COG3291@1|root,COG3291@2|Bacteria,4NG09@976|Bacteroidetes,1HY3Z@117743|Flavobacteriia,3ZPCK@59732|Chryseobacterium 976|Bacteroidetes S Metalloprotease - - - - - - - - - - - - FTP,PA,PKD,Peptidase_M36 k59_1633250_1 313628.LNTAR_22309 2.9e-28 113.0 COG3119@1|root,COG3119@2|Bacteria 2|Bacteria P arylsulfatase activity - - - - - - - - - - - - Sulfatase k59_168247_1 457429.ABJI02000794_gene6122 2.11e-66 218.0 COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_69778_1 1123371.ATXH01000008_gene227 1.65e-32 125.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2GGQS@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Competence-damaged protein - - 3.5.1.42 ko:K03742 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth k59_69778_2 1184267.A11Q_556 1.51e-10 62.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,42M69@68525|delta/epsilon subdivisions,2MSU5@213481|Bdellovibrionales,2WIYC@28221|Deltaproteobacteria 213481|Bdellovibrionales L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_1217236_1 420324.KI911970_gene1564 4.19e-41 150.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_168253_1 436308.Nmar_0582 2.21e-127 369.0 COG0150@1|root,arCOG00639@2157|Archaea,41SEE@651137|Thaumarchaeota 651137|Thaumarchaeota F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_117903_1 436308.Nmar_0433 7.25e-47 157.0 COG2123@1|root,arCOG01574@2157|Archaea,41SFZ@651137|Thaumarchaeota 651137|Thaumarchaeota J Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site rrp42 - - ko:K12589 ko03018,map03018 M00390,M00391 - - ko00000,ko00001,ko00002,ko03019 - - - RNase_PH,RNase_PH_C k59_117903_2 1229909.NSED_02255 1.55e-38 129.0 COG1997@1|root,arCOG04208@2157|Archaea,41SUE@651137|Thaumarchaeota 651137|Thaumarchaeota J Ribosomal L37ae protein family rpl37ae - - ko:K02921 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L37ae k59_588084_1 1207063.P24_11210 1.56e-88 267.0 COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,2TVMU@28211|Alphaproteobacteria,2JU2U@204441|Rhodospirillales 204441|Rhodospirillales I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit - - 2.8.3.12 ko:K01039 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_327604_1 1403819.BATR01000085_gene2489 1.78e-10 62.0 2C8PG@1|root,32RMK@2|Bacteria,46VCB@74201|Verrucomicrobia 74201|Verrucomicrobia - - - - - - - - - - - - - - - k59_1633269_1 1057002.KB905370_gene3672 7.54e-53 188.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,4BB6Z@82115|Rhizobiaceae 28211|Alphaproteobacteria P cation efflux system protein (Heavy metal efflux pump) - - - - - - - - - - - - ACR_tran k59_1271180_1 667014.Thein_1907 5.15e-60 197.0 COG0123@1|root,COG0123@2|Bacteria,2GHD6@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl k59_327606_1 886293.Sinac_7122 4.27e-26 102.0 COG1476@1|root,COG1476@2|Bacteria,2J1I8@203682|Planctomycetes 203682|Planctomycetes K TRANSCRIPTIONal - - - - - - - - - - - - - k59_6439_1 880073.Calab_2811 4.82e-61 207.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,2NPC4@2323|unclassified Bacteria 2|Bacteria P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - iAF987.Gmet_3470 CBS,TrkA_C,Voltage_CLC k59_380130_1 272631.ML1959 8.2e-15 70.5 COG0100@1|root,COG0100@2|Bacteria,2IFFC@201174|Actinobacteria,238NX@1762|Mycobacteriaceae 201174|Actinobacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_380130_2 1191523.MROS_0192 3.98e-40 136.0 COG0099@1|root,COG0099@2|Bacteria 2|Bacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_1479208_1 582744.Msip34_1788 1.31e-102 312.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,2VHA7@28216|Betaproteobacteria,2KMAD@206350|Nitrosomonadales 206350|Nitrosomonadales H Catalyzes the oxidation of L-aspartate to iminoaspartate - - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1058518_1 1232410.KI421425_gene1554 3.23e-46 169.0 COG1361@1|root,COG1361@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria,43TPS@69541|Desulfuromonadales 28221|Deltaproteobacteria M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11,SdrD_B k59_901807_1 926569.ANT_19480 3.79e-78 254.0 COG1138@1|root,COG1138@2|Bacteria,2G5SZ@200795|Chloroflexi 200795|Chloroflexi O PFAM Cytochrome C assembly protein ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_69819_2 228410.NE1659 3.07e-09 58.5 COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,2VMTY@28216|Betaproteobacteria,372DF@32003|Nitrosomonadales 28216|Betaproteobacteria S L,D-transpeptidase catalytic domain - - - ko:K16291 - - - - ko00000,ko01002,ko01011 - - - YkuD k59_953353_1 387631.Asulf_01897 4.19e-21 94.4 COG4034@1|root,arCOG04164@2157|Archaea,2XWRA@28890|Euryarchaeota,2466C@183980|Archaeoglobi 183980|Archaeoglobi S Protein of unknown function (DUF1152) - - - - - - - - - - - - DUF1152 k59_1110777_1 36809.MAB_2389 6.14e-62 207.0 COG1053@1|root,COG1053@2|Bacteria,2GKS3@201174|Actinobacteria,233SE@1762|Mycobacteriaceae 201174|Actinobacteria C Succinate dehydrogenase fumarate reductase flavoprotein subunit ifcA - 1.3.99.5 ko:K16051 ko00984,ko01120,map00984,map01120 - R01834 RC00145 ko00000,ko00001,ko01000 - - - FAD_binding_2 k59_694560_1 522306.CAP2UW1_3910 2.2e-67 229.0 COG0204@1|root,COG0236@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0236@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria 28216|Betaproteobacteria IQ amp-dependent synthetase and ligase - - - - - - - - - - - - AMP-binding,Acyltransferase,PP-binding k59_1523950_1 998674.ATTE01000001_gene497 4.87e-12 65.1 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,4608B@72273|Thiotrichales 72273|Thiotrichales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_1523950_2 317013.NY99_18395 4.8e-48 159.0 COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1X63Y@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the Smg family smg - - ko:K03747 - - - - ko00000 - - - DUF494 k59_1523950_3 105559.Nwat_3069 5.36e-12 65.9 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1WWKX@135613|Chromatiales 135613|Chromatiales LU TIGRFAM DNA protecting protein DprA - - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_380173_1 243164.DET1141 5.12e-24 105.0 COG0726@1|root,COG1215@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,2G76U@200795|Chloroflexi,34CUR@301297|Dehalococcoidia 301297|Dehalococcoidia GM Polysaccharide deacetylase - - - - - - - - - - - - Glycos_transf_2,Polysacc_deac_1 k59_1110783_2 330214.NIDE1315 2.13e-61 188.0 COG0185@1|root,COG0185@2|Bacteria,3J0MU@40117|Nitrospirae 40117|Nitrospirae J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_485666_1 395493.BegalDRAFT_2300 3.48e-78 261.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,45ZWV@72273|Thiotrichales 72273|Thiotrichales E Glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_953366_1 1128427.KB904821_gene3206 8.9e-41 149.0 COG1073@1|root,COG1073@2|Bacteria,1G1YP@1117|Cyanobacteria,1H80J@1150|Oscillatoriales 1117|Cyanobacteria S Alpha beta - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4,PhoPQ_related k59_953366_2 472759.Nhal_2864 1.19e-22 96.7 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1WWUF@135613|Chromatiales 135613|Chromatiales S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_588132_1 545243.BAEV01000010_gene1103 2.61e-47 165.0 COG0649@1|root,COG0649@2|Bacteria,1TQAR@1239|Firmicutes,24EDV@186801|Clostridia,36UKX@31979|Clostridiaceae 186801|Clostridia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_327652_1 1150626.PHAMO_230010 5.57e-42 151.0 COG3016@1|root,COG3016@2|Bacteria,1NXYQ@1224|Proteobacteria,2U0QY@28211|Alphaproteobacteria,2JSES@204441|Rhodospirillales 204441|Rhodospirillales O Haem-binding uptake, Tiki superfamily, ChaN - - - - - - - - - - - - Cofac_haem_bdg k59_644496_2 572477.Alvin_1884 7.92e-53 169.0 COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria,1WYAQ@135613|Chromatiales 135613|Chromatiales NU PFAM Type IV pilus assembly PilZ - - - ko:K02676 - - - - ko00000,ko02035,ko02044 - - - PilZ k59_644496_3 105559.Nwat_1452 3.25e-09 57.4 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,1RP6E@1236|Gammaproteobacteria,1WXA1@135613|Chromatiales 135613|Chromatiales L TIGRFAM hydrolase, TatD family - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_1580182_1 502025.Hoch_1742 8.88e-103 322.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2YTUI@29|Myxococcales 28221|Deltaproteobacteria P copper-translocating P-type ATPase copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_1371756_1 880073.Calab_1754 2.55e-12 73.9 COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2NQ6Y@2323|unclassified Bacteria 2|Bacteria M PKD domain - - 3.2.1.4,3.4.21.66 ko:K01179,ko:K08651 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000,ko01002,ko03110 - GH5,GH9 - Autotransporter,PKD,Peptidase_S8,Peptidase_S8_N,fn3 k59_125857_1 1049564.TevJSym_aq00680 5.1e-14 69.7 COG4660@1|root,COG4660@2|Bacteria,1R342@1224|Proteobacteria,1T62W@1236|Gammaproteobacteria,1JBVX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport rnfE2 - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_125857_2 1049564.TevJSym_aq00690 7.88e-38 134.0 COG4659@1|root,COG4659@2|Bacteria,1REZV@1224|Proteobacteria,1T054@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport - - - - - - - - - - - - FMN_bind k59_1065153_1 1165096.ARWF01000001_gene1460 7.09e-05 43.9 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2VI55@28216|Betaproteobacteria,2KM45@206350|Nitrosomonadales 206350|Nitrosomonadales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_1065153_2 388467.A19Y_3175 2.39e-53 185.0 COG2307@1|root,COG2307@2|Bacteria,1G05F@1117|Cyanobacteria,1H8SU@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Bacterial domain of - - - - - - - - - - - - Alpha-E k59_959357_1 105559.Nwat_0949 8.36e-18 76.3 COG0011@1|root,COG0011@2|Bacteria,1N1NM@1224|Proteobacteria,1SAV8@1236|Gammaproteobacteria,1WZPV@135613|Chromatiales 135613|Chromatiales S Thiamine-binding protein - - - - - - - - - - - - Thiamine_BP k59_1586805_1 330214.NIDE4384 5.83e-94 290.0 COG0397@1|root,COG0397@2|Bacteria 2|Bacteria S Uncharacterized ACR, YdiU/UPF0061 family ydiU - - ko:K08997 - - - - ko00000 - - - UPF0061 k59_9336_1 290398.Csal_2437 3.6e-35 129.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1XH86@135619|Oceanospirillales 135619|Oceanospirillales O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_9336_2 1288826.MSNKSG1_07373 1.3e-06 50.1 COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,1RYD7@1236|Gammaproteobacteria,465QZ@72275|Alteromonadaceae 1236|Gammaproteobacteria O May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ate GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 2.3.2.29 ko:K21420 - - R11547,R11548 RC00064 ko00000,ko01000 - - - ATE_C,ATE_N k59_856034_1 391615.ABSJ01000054_gene1390 1.23e-46 171.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1J4DR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_541818_1 319795.Dgeo_1304 2.58e-83 265.0 COG0166@1|root,COG0166@2|Bacteria,1WIGN@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_652867_1 1123508.JH636443_gene4999 5.39e-22 99.4 COG2199@1|root,COG3290@1|root,COG3290@2|Bacteria,COG3706@2|Bacteria,2IYJM@203682|Planctomycetes 203682|Planctomycetes T GGDEF domain - - - - - - - - - - - - GGDEF,HD,PAS_4 k59_281582_1 1121878.AUGL01000009_gene3298 6.1e-33 128.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated - - - - - - - - - - - - AI-2E_transport k59_751077_1 1248916.ANFY01000007_gene2146 1.29e-42 157.0 COG0665@1|root,COG0665@2|Bacteria,1QWQF@1224|Proteobacteria,2U1W6@28211|Alphaproteobacteria,2K4RA@204457|Sphingomonadales 204457|Sphingomonadales E NAD(P)-binding Rossmann-like domain - - - - - - - - - - - - NAD_binding_8 k59_494084_1 767817.Desgi_2132 2.21e-68 225.0 COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24BRX@186801|Clostridia,260H8@186807|Peptococcaceae 186801|Clostridia H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1166576_1 330214.NIDE1518 2.08e-41 141.0 COG1573@1|root,COG1573@2|Bacteria,3J0MR@40117|Nitrospirae 40117|Nitrospirae L Uracil DNA glycosylase superfamily - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_438688_2 234267.Acid_2283 4.64e-17 86.3 COG0526@1|root,COG0526@2|Bacteria,3Y4MM@57723|Acidobacteria 57723|Acidobacteria CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA k59_751080_1 187272.Mlg_0533 8.06e-45 162.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1WWT6@135613|Chromatiales 135613|Chromatiales M Surface antigen variable number - - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 k59_1487591_1 458817.Shal_3364 9.07e-198 563.0 COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,1RQK5@1236|Gammaproteobacteria,2QAED@267890|Shewanellaceae 1236|Gammaproteobacteria C PFAM NADH Ubiquinone plastoquinone (complex I) - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_1487591_2 1120953.AUBH01000002_gene1384 1.81e-25 97.8 2EAIM@1|root,334MN@2|Bacteria,1N6XM@1224|Proteobacteria,1SF6C@1236|Gammaproteobacteria,469A2@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1487591_3 523791.Kkor_0770 6.98e-135 399.0 COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria,1XH7B@135619|Oceanospirillales 135619|Oceanospirillales CP Proton-conducting membrane transporter - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M,Proton_antipo_N k59_1528422_1 56110.Oscil6304_1674 7.56e-67 217.0 COG2046@1|root,COG2046@2|Bacteria,1G0E8@1117|Cyanobacteria,1H7XJ@1150|Oscillatoriales 1117|Cyanobacteria P Belongs to the sulfate adenylyltransferase family sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_78240_1 396588.Tgr7_0560 5.19e-34 130.0 COG2170@1|root,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,1RPKZ@1236|Gammaproteobacteria,1WWXK@135613|Chromatiales 135613|Chromatiales S glutamate--cysteine ligase - - - - - - - - - - - - GCS2 k59_78240_2 1249627.D779_3881 2.92e-27 105.0 COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,1WWYC@135613|Chromatiales 135613|Chromatiales JM PFAM Nucleotidyl transferase - - 2.7.7.99 ko:K00992 ko00520,ko01100,map00520,map01100 - R11025 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_494101_2 392499.Swit_3652 2.91e-51 166.0 COG1545@1|root,COG1545@2|Bacteria,1N7HH@1224|Proteobacteria,2UFFB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Rubredoxin-like zinc ribbon domain (DUF35_N) - - - - - - - - - - - - DUF35_N,OB_aCoA_assoc k59_494101_3 2002.JOEQ01000001_gene4845 2.78e-94 286.0 COG0183@1|root,COG0183@2|Bacteria,2GKFR@201174|Actinobacteria,4EH0H@85012|Streptosporangiales 201174|Actinobacteria I lipid-transfer protein - - - - - - - - - - - - - k59_856061_1 436308.Nmar_1663 2.48e-71 224.0 COG2132@1|root,arCOG03914@2157|Archaea,41S77@651137|Thaumarchaeota 651137|Thaumarchaeota Q PFAM Multicopper oxidase - - - - - - - - - - - - Cu-oxidase_2,Cu-oxidase_3 k59_856061_2 1229909.NSED_01590 6.56e-23 96.3 COG0428@1|root,arCOG00576@2157|Archaea,41S6R@651137|Thaumarchaeota 651137|Thaumarchaeota P divalent heavy-metal cations transporter - - - - - - - - - - - - - k59_1487608_1 44056.XP_009040305.1 3.71e-05 53.1 COG0421@1|root,KOG1562@2759|Eukaryota 2759|Eukaryota E spermidine synthase activity SPS1 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0008150,GO:0009888,GO:0009914,GO:0009926,GO:0009987,GO:0010087,GO:0010089,GO:0010487,GO:0010817,GO:0016740,GO:0016765,GO:0016768,GO:0030154,GO:0032502,GO:0044424,GO:0044464,GO:0048759,GO:0048856,GO:0048869,GO:0051179,GO:0051234,GO:0060918,GO:0065007,GO:0065008,GO:1905177 2.5.1.79 ko:K18787 - - - - ko00000,ko01000 - - - Spermine_synt_N,Spermine_synth k59_1279941_1 87626.PTD2_09642 9.9e-18 82.0 COG3160@1|root,COG3160@2|Bacteria,1RHBB@1224|Proteobacteria,1S420@1236|Gammaproteobacteria,2Q19G@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K Belongs to the Rsd AlgQ family rsd GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - ko:K07740 - - - - ko00000 - - - Rsd_AlgQ k59_1065189_2 28564.XP_002480815.1 2.67e-09 61.2 COG0484@1|root,KOG0714@2759|Eukaryota,39TYJ@33154|Opisthokonta,3P0U5@4751|Fungi,3QMD0@4890|Ascomycota,20GJH@147545|Eurotiomycetes,3S7EC@5042|Eurotiales 4751|Fungi O DnaJ chaperone (Caj1) - GO:0003674,GO:0005488,GO:0005515,GO:0030544,GO:0031072 - ko:K17867 - - - - ko00000,ko03012 - - - DnaJ k59_228822_1 1382359.JIAL01000001_gene2432 8.16e-06 48.9 COG0597@1|root,COG0597@2|Bacteria 2|Bacteria MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_1586850_1 1173264.KI913949_gene2337 9.91e-61 204.0 COG0119@1|root,COG0119@2|Bacteria,1G0DK@1117|Cyanobacteria,1H7S4@1150|Oscillatoriales 1117|Cyanobacteria E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1012274_1 335543.Sfum_3971 5.57e-94 288.0 COG2308@1|root,COG2308@2|Bacteria,1NG4H@1224|Proteobacteria,42WK0@68525|delta/epsilon subdivisions,2WS0X@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - k59_388540_1 1121904.ARBP01000006_gene3911 6.25e-32 123.0 COG0398@1|root,COG0398@2|Bacteria,4NIT2@976|Bacteroidetes,47KFE@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function, DUF547 - - - - - - - - - - - - DUF547 k59_1487624_1 349124.Hhal_0864 5.74e-77 257.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_494127_1 2340.JV46_17160 5.69e-60 200.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1J5M7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_494127_2 1038859.AXAU01000017_gene6299 2.66e-09 57.4 COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2TQN7@28211|Alphaproteobacteria,3JQSS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O OsmC-like protein MA20_16590 - - ko:K06889,ko:K07397 - - - - ko00000 - - - Hydrolase_4,OsmC k59_1528436_1 795666.MW7_1228 3.3e-40 149.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,1K0X6@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the GMC oxidoreductase family - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_1322996_1 469371.Tbis_1850 3.64e-06 52.4 COG0747@1|root,COG0747@2|Bacteria,2GJXH@201174|Actinobacteria,4E026@85010|Pseudonocardiales 201174|Actinobacteria E extracellular solute-binding protein, family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_751116_1 90814.KL370891_gene41 4.76e-74 231.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,45ZPX@72273|Thiotrichales 72273|Thiotrichales H Belongs to the ALAD family - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_1433938_3 1589733.A0A0C5AIS4_9CAUD 4.81e-75 227.0 4QDU7@10239|Viruses,4QPYQ@28883|Caudovirales,4QJID@10662|Myoviridae 10662|Myoviridae S Staphylococcal nuclease homologue - - - - - - - - - - - - - k59_1323011_1 114615.BRADO0919 6.89e-57 187.0 COG0625@1|root,COG0625@2|Bacteria,1Q9ND@1224|Proteobacteria,2TT22@28211|Alphaproteobacteria,3JX9Z@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Glutathione S-transferase, C-terminal domain - - - - - - - - - - - - GST_C_2,GST_N_3 k59_1323011_2 497964.CfE428DRAFT_2702 1.12e-07 52.4 COG1878@1|root,COG1878@2|Bacteria 2|Bacteria S arylformamidase activity - - - - - - - - - - - - Cyclase k59_173717_1 1184267.A11Q_2597 1.01e-81 263.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2MSUA@213481|Bdellovibrionales,2WIPT@28221|Deltaproteobacteria 213481|Bdellovibrionales CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein nuoL-1 - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_1528453_1 1232410.KI421425_gene1552 1.41e-124 397.0 COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales 28221|Deltaproteobacteria M OmpA family - - - - - - - - - - - - OmpA k59_438727_1 856793.MICA_1457 4.81e-94 300.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,4BP6T@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1640638_2 1123366.TH3_19987 1.36e-21 94.7 COG1178@1|root,COG1178@2|Bacteria,1R0MN@1224|Proteobacteria,2VFDY@28211|Alphaproteobacteria,2JWHI@204441|Rhodospirillales 204441|Rhodospirillales P Binding-protein-dependent transport system inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_388570_1 395493.BegalDRAFT_1486 9.58e-89 275.0 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,1RQEA@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Iron-sulfur cluster binding protein - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_17,Fer4_4,Fer4_7,Fer4_8,LUD_dom k59_494198_2 268746.Q58M37_BPPRM 4.53e-32 117.0 4QD3S@10239|Viruses,4QS0E@28883|Caudovirales,4QK4Z@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_653007_1 1121127.JAFA01000010_gene4032 9.41e-45 155.0 COG0625@1|root,COG0625@2|Bacteria,1RHXQ@1224|Proteobacteria,2W2WE@28216|Betaproteobacteria 28216|Betaproteobacteria O glutathione transferase activity - - - - - - - - - - - - - k59_959438_1 196367.JNFG01000199_gene3546 4.65e-57 192.0 COG2850@1|root,COG2850@2|Bacteria,1Q0IG@1224|Proteobacteria,2W5CH@28216|Betaproteobacteria 28216|Betaproteobacteria S A domain family that is part of the cupin metalloenzyme superfamily. - - 1.14.11.47 ko:K18850 - - - - ko00000,ko01000,ko03009 - - - Cupin_4 k59_751140_1 199310.c3520 6.58e-141 417.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,3XMMK@561|Escherichia 1236|Gammaproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tktA GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - iSDY_1059.SDY_3141,iYL1228.KPN_01127 Transket_pyr,Transketolase_C,Transketolase_N k59_1065242_1 153948.NAL212_1529 3.37e-13 68.6 COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,2VWK8@28216|Betaproteobacteria,3741A@32003|Nitrosomonadales 28216|Betaproteobacteria O Redoxin domain protein - - - - - - - - - - - - AhpC-TSA,Redoxin k59_1065242_2 1123279.ATUS01000003_gene528 2.04e-13 65.9 2DIKV@1|root,303K3@2|Bacteria,1PI5E@1224|Proteobacteria,1TFEX@1236|Gammaproteobacteria,1JBJH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4266) - - - - - - - - - - - - DUF4266 k59_281647_1 330214.NIDE3905 2.72e-18 81.3 COG1814@1|root,COG1814@2|Bacteria 2|Bacteria S cellular manganese ion homeostasis - - - - - - - - - - - - VIT1 k59_810137_1 1229909.NSED_01190 3.76e-151 439.0 COG1053@1|root,arCOG00571@2157|Archaea,41SAM@651137|Thaumarchaeota 651137|Thaumarchaeota C fumarate reductase flavoprotein - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_856128_1 287.DR97_5851 5.04e-66 218.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,1RPGT@1236|Gammaproteobacteria,1YE4H@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Acetyl-coenzyme A synthetase N-terminus acsA - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_541912_1 1237149.C900_05708 6.12e-69 231.0 COG0243@1|root,COG0243@2|Bacteria,4NF6W@976|Bacteroidetes,47K7G@768503|Cytophagia 976|Bacteroidetes C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhF - - - - - - - - - - - Molybdopterin,Molydop_binding k59_1117174_1 709797.CSIRO_2970 3.48e-69 221.0 COG1024@1|root,COG1024@2|Bacteria,1MWF6@1224|Proteobacteria,2TVBC@28211|Alphaproteobacteria,3JSPF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_173745_1 563008.HMPREF0665_02066 6.59e-08 55.5 COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,2FM2N@200643|Bacteroidia 976|Bacteroidetes T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_173745_2 1219065.VPR01S_02_01710 7.7e-10 62.8 COG2204@1|root,COG2204@2|Bacteria,1QUG8@1224|Proteobacteria,1T1Y0@1236|Gammaproteobacteria,1XT04@135623|Vibrionales 135623|Vibrionales T COG0784 FOG CheY-like receiver rssB - - - - - - - - - - - Response_reg k59_1280092_1 379066.GAU_3103 1.72e-31 128.0 COG1572@1|root,COG2304@1|root,COG1572@2|Bacteria,COG2304@2|Bacteria,1ZUB7@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Aerotolerance regulator N-terminal - - - - - - - - - - - - BatA,VWA_2 k59_1586926_2 1229909.NSED_03360 3.01e-25 102.0 COG4608@1|root,arCOG00184@2157|Archaea,41S9E@651137|Thaumarchaeota 651137|Thaumarchaeota E Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_1377873_1 99598.Cal7507_2078 3.31e-11 62.8 COG1087@1|root,COG1087@2|Bacteria,1G2HG@1117|Cyanobacteria,1HJ9T@1161|Nostocales 1117|Cyanobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_1377873_2 715451.ambt_03385 1.81e-09 60.5 COG5184@1|root,COG5184@2|Bacteria,1QXKC@1224|Proteobacteria,1T3DX@1236|Gammaproteobacteria,46D9E@72275|Alteromonadaceae 1236|Gammaproteobacteria DZ protein contain chitin-binding domain type 3 - - - - - - - - - - - - - k59_909456_1 1122603.ATVI01000011_gene2049 1.03e-08 57.4 COG0457@1|root,COG0515@1|root,COG3710@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG3710@2|Bacteria,1NI1Y@1224|Proteobacteria,1S2FD@1236|Gammaproteobacteria,1X4HE@135614|Xanthomonadales 135614|Xanthomonadales KLT Protein kinase domain - - - - - - - - - - - - Pkinase,TPR_10,TPR_12,TPR_8,Trans_reg_C k59_1066217_2 443144.GM21_3391 1.3e-94 284.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,42M4J@68525|delta/epsilon subdivisions,2WJM8@28221|Deltaproteobacteria,43T7P@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM ABC transporter related lptB - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_966164_1 264198.Reut_B4151 2.08e-134 399.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VJGI@28216|Betaproteobacteria,1K3UJ@119060|Burkholderiaceae 28216|Betaproteobacteria C CoA-transferase family III - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_819118_1 696369.KI912183_gene2682 1.99e-15 77.4 COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia,261MZ@186807|Peptococcaceae 186801|Clostridia O PFAM Peptidase M22, glycoprotease yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Acetyltransf_1,Peptidase_M22 k59_819118_2 1123261.AXDW01000005_gene2503 0.000817 42.4 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1X3KG@135614|Xanthomonadales 135614|Xanthomonadales M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_707446_1 483219.LILAB_00890 4.74e-63 206.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,42PZJ@68525|delta/epsilon subdivisions,2WMGB@28221|Deltaproteobacteria,2YVBK@29|Myxococcales 28221|Deltaproteobacteria E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 k59_1496523_1 671143.DAMO_1537 2.32e-63 208.0 COG1653@1|root,COG1653@2|Bacteria,2NP9E@2323|unclassified Bacteria 2|Bacteria G Bacterial extracellular solute-binding protein thuE - - ko:K02027,ko:K10236 ko02010,map02010 M00204,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.17 - - SBP_bac_1,SBP_bac_8 k59_288542_1 999141.GME_14510 9.34e-91 281.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1XHSK@135619|Oceanospirillales 135619|Oceanospirillales J SAM-dependent - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_1534031_1 1121930.AQXG01000014_gene377 4.39e-96 293.0 COG0489@1|root,COG0489@2|Bacteria,4NF5I@976|Bacteroidetes,1IQKF@117747|Sphingobacteriia 976|Bacteroidetes D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_393945_1 1121877.JQKF01000008_gene622 2.13e-58 193.0 COG0119@1|root,COG0119@2|Bacteria,2GKTP@201174|Actinobacteria,4CMYN@84992|Acidimicrobiia 84992|Acidimicrobiia E HMGL-like - - 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_757637_1 1249627.D779_4053 1.07e-74 231.0 COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,1S22U@1236|Gammaproteobacteria,1X0RX@135613|Chromatiales 135613|Chromatiales M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_86929_1 436308.Nmar_0248 3.17e-58 188.0 COG0115@1|root,arCOG02297@2157|Archaea,41S5T@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_1593408_1 1116369.KB890024_gene3645 2.77e-20 90.1 COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,2VGUT@28211|Alphaproteobacteria,43JGI@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E N-formylglutamate amidohydrolase - - - - - - - - - - - - FGase k59_662017_1 864702.OsccyDRAFT_3828 8.71e-119 355.0 COG1215@1|root,COG1215@2|Bacteria,1G1PN@1117|Cyanobacteria,1H9ZX@1150|Oscillatoriales 1117|Cyanobacteria M Glycosyl transferase family 21 - - - - - - - - - - - - Glyco_tranf_2_3,Glyco_trans_2_3 k59_446593_1 236097.ADG881_795 8.02e-65 217.0 COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,1RNU3@1236|Gammaproteobacteria,1XI15@135619|Oceanospirillales 135619|Oceanospirillales S protein containing a von Willebrand factor type A (vWA) domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_12726_2 1125863.JAFN01000001_gene206 4.19e-23 99.4 COG1381@1|root,COG1381@2|Bacteria 2|Bacteria L Involved in DNA repair and RecF pathway recombination recO GO:0008150,GO:0009314,GO:0009628,GO:0050896 2.6.99.2 ko:K03474,ko:K03584 ko00750,ko01100,ko03440,map00750,map01100,map03440 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000,ko03400 - - - RecO_C,RecO_N k59_966183_2 649638.Trad_0146 1.35e-14 75.1 COG1957@1|root,COG1957@2|Bacteria 2|Bacteria F ribosylpyrimidine nucleosidase activity - - - - - - - - - - - - IU_nuc_hydro k59_1172201_1 765912.Thimo_3650 3.29e-83 260.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WX6V@135613|Chromatiales 135613|Chromatiales E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1172201_2 314278.NB231_13431 2.44e-101 297.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1WVVN@135613|Chromatiales 135613|Chromatiales EH TIGRFAM glutamine amidotransferase of anthranilate synthase - - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_288568_1 338963.Pcar_1696 6.14e-21 87.4 294M8@1|root,34B0H@2|Bacteria,1P2RM@1224|Proteobacteria,43174@68525|delta/epsilon subdivisions,2WWJZ@28221|Deltaproteobacteria,43VJJ@69541|Desulfuromonadales 28221|Deltaproteobacteria S PilZ domain - - - - - - - - - - - - PilZ k59_1649832_2 1198232.CYCME_0513 2.25e-71 221.0 COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,1S3XB@1236|Gammaproteobacteria,462B0@72273|Thiotrichales 72273|Thiotrichales F Nudix N-terminal - - - - - - - - - - - - NUDIX,Nudix_N_2 k59_1649832_3 1121935.AQXX01000121_gene5604 7.06e-48 164.0 COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,1XJIV@135619|Oceanospirillales 135619|Oceanospirillales E COG2755 Lysophospholipase L1 and related esterases tesA - 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - Lipase_GDSL_2 k59_1496567_1 1408428.JNJP01000021_gene2219 4.56e-17 86.3 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,42PSZ@68525|delta/epsilon subdivisions,2WMBH@28221|Deltaproteobacteria,2M8PJ@213115|Desulfovibrionales 28221|Deltaproteobacteria S TamB, inner membrane protein subunit of TAM complex - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_662050_1 1469245.JFBG01000006_gene1580 2.16e-108 322.0 COG2141@1|root,COG2141@2|Bacteria,1R9CH@1224|Proteobacteria,1RZ9F@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_757657_1 935567.JAES01000007_gene1910 2.06e-102 310.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RN5B@1236|Gammaproteobacteria,1X32P@135614|Xanthomonadales 135614|Xanthomonadales E aminotransferase - - 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1233024_1 868864.Dester_0409 1.41e-84 256.0 COG0177@1|root,COG0177@2|Bacteria,2G3TX@200783|Aquificae 200783|Aquificae L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_12745_1 1049564.TevJSym_ar00020 4.07e-65 210.0 COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,1RZQ2@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q PFAM Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_601299_1 744985.HIMB59_00004520 5.36e-150 430.0 COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria,2TRY8@28211|Alphaproteobacteria,4BRUV@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Bacterial extracellular solute-binding protein - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 k59_915338_1 756067.MicvaDRAFT_0295 1.58e-67 216.0 COG0604@1|root,COG0604@2|Bacteria,1FZW8@1117|Cyanobacteria,1H6ZN@1150|Oscillatoriales 1117|Cyanobacteria C COG0604 NADPH quinone reductase and related Zn-dependent - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N_2 k59_86961_1 41431.PCC8801_1138 2.34e-15 80.1 COG0834@1|root,COG0834@2|Bacteria,1G1D2@1117|Cyanobacteria,3KGEF@43988|Cyanothece 1117|Cyanobacteria ET PFAM extracellular solute-binding protein family 3 glnH - - ko:K02030,ko:K09969 ko02010,map02010 M00232,M00236 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - SBP_bac_3 k59_12749_1 981369.JQMJ01000004_gene3684 6.11e-16 74.3 COG2963@1|root,COG2963@2|Bacteria,2IM4Y@201174|Actinobacteria,2NIZH@228398|Streptacidiphilus 201174|Actinobacteria L PFAM transposase IS3 IS911 family protein - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_12749_2 246197.MXAN_4473 1.91e-124 364.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,42M98@68525|delta/epsilon subdivisions,2WMKB@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Integrase catalytic - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve k59_915345_1 713586.KB900536_gene290 3.71e-48 166.0 COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,1RZ65@1236|Gammaproteobacteria,1WWIJ@135613|Chromatiales 135613|Chromatiales S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 k59_601313_1 867845.KI911784_gene1847 3.72e-07 57.8 COG0664@1|root,COG2172@1|root,COG2208@1|root,COG0664@2|Bacteria,COG2172@2|Bacteria,COG2208@2|Bacteria,2G790@200795|Chloroflexi,376A8@32061|Chloroflexia 32061|Chloroflexia KT SMART protein phosphatase 2C domain protein - - - - - - - - - - - - HATPase_c_2,SpoIIE,cNMP_binding k59_1018903_1 1535422.ND16A_3571 4e-78 243.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,2Q707@267889|Colwelliaceae 1236|Gammaproteobacteria L Transposase - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_662084_1 997346.HMPREF9374_2276 4.77e-32 122.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,4HAMQ@91061|Bacilli,27BNY@186824|Thermoactinomycetaceae 91061|Bacilli E Rad17 cell cycle checkpoint protein msmX - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE,TOBE_2 k59_662084_2 671143.DAMO_1535 4.59e-98 294.0 COG0395@1|root,COG0395@2|Bacteria,2NPBC@2323|unclassified Bacteria 2|Bacteria U Binding-protein-dependent transport system inner membrane component sugB - - ko:K02026,ko:K10238 ko02010,map02010 M00204,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.17 - - BPD_transp_1 k59_1649878_1 1123229.AUBC01000007_gene202 7.34e-32 129.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,3JR5K@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Penicillin-binding Protein pbpC - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_1072083_2 869662.M4PML3_9CAUD 4.34e-25 102.0 4QF0I@10239|Viruses,4QQCF@28883|Caudovirales,4QIT0@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_819217_1 330214.NIDE0473 1.33e-90 276.0 COG4307@1|root,COG4307@2|Bacteria 2|Bacteria T Protein conserved in bacteria - - - - - - - - - - - - Peptidase_Mx,zinc-ribbon_6 k59_12782_1 521674.Plim_2324 3.02e-43 160.0 COG1391@1|root,COG1391@2|Bacteria,2IXPE@203682|Planctomycetes 203682|Planctomycetes H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell - - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_179223_1 744980.TRICHSKD4_5109 4.07e-18 87.0 COG2114@1|root,COG2114@2|Bacteria,1RG4J@1224|Proteobacteria,2U7PQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Adenylate cyclase cyaJ - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc k59_915395_1 477228.YO5_11405 4.37e-42 154.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria,1Z07C@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD GO:0000166,GO:0003674,GO:0003824,GO:0004368,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006072,GO:0006091,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009331,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016901,GO:0019637,GO:0022900,GO:0031224,GO:0031226,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046168,GO:0046434,GO:0048037,GO:0050660,GO:0050662,GO:0052590,GO:0052646,GO:0055114,GO:0071704,GO:0071944,GO:0071949,GO:0097159,GO:1901135,GO:1901136,GO:1901265,GO:1901363,GO:1901575,GO:1902494,GO:1990204 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - iSSON_1240.SSON_3663 DAO,DAO_C k59_1383969_1 981336.F944_03250 1.55e-54 186.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,3NJT4@468|Moraxellaceae 1236|Gammaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009226,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0018130,GO:0019134,GO:0019438,GO:0030203,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046872,GO:0055086,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_4420,iYL1228.KPN_04135 Hexapep,Hexapep_2,NTP_transf_3 k59_1124100_1 314260.PB2503_12544 6.4e-16 72.4 COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_Tnp_1 k59_1233060_2 237368.SCABRO_03044 2.88e-22 99.4 COG2204@1|root,COG2204@2|Bacteria,2IXIQ@203682|Planctomycetes 203682|Planctomycetes T Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_966250_2 1262527.L7TGL2_9VIRU 2.95e-13 70.5 4QFNP@10239|Viruses,4QX3W@35237|dsDNA viruses no RNA stage 10239|Viruses - - - - - - - - - - - - - - - k59_967216_1 1122247.C731_4802 4.77e-70 219.0 COG1335@1|root,COG1335@2|Bacteria,2I81Y@201174|Actinobacteria,235ZP@1762|Mycobacteriaceae 201174|Actinobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_967216_2 1007105.PT7_3036 9.59e-27 113.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria,3T5HE@506|Alcaligenaceae 28216|Betaproteobacteria I Carboxyl transferase domain pccB - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_758645_1 469383.Cwoe_3508 9.05e-78 251.0 COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4CR6V@84995|Rubrobacteria 84995|Rubrobacteria I AMP-binding enzyme - - - - - - - - - - - - AMP-binding k59_1125470_1 497964.CfE428DRAFT_6231 5.56e-24 109.0 COG0745@1|root,COG5000@1|root,COG0745@2|Bacteria,COG5000@2|Bacteria,46S9G@74201|Verrucomicrobia 74201|Verrucomicrobia T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg k59_1498012_1 1123072.AUDH01000003_gene944 1.54e-56 190.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2TQMD@28211|Alphaproteobacteria,2JPKA@204441|Rhodospirillales 204441|Rhodospirillales GM NmrA-like family - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - 3Beta_HSD,Epimerase,NAD_binding_10,RmlD_sub_bind k59_820585_1 261292.Nit79A3_1690 2.38e-46 164.0 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria,3726P@32003|Nitrosomonadales 28216|Betaproteobacteria M PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C dacB - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_1019861_1 330214.NIDE0473 9.43e-17 80.1 COG4307@1|root,COG4307@2|Bacteria 2|Bacteria T Protein conserved in bacteria - - - - - - - - - - - - Peptidase_Mx,zinc-ribbon_6 k59_1019861_2 1134413.ANNK01000106_gene1641 1.43e-47 166.0 COG0300@1|root,COG0300@2|Bacteria,1TSJ3@1239|Firmicutes,4HDU5@91061|Bacilli,1ZBRZ@1386|Bacillus 91061|Bacilli S Belongs to the short-chain dehydrogenases reductases (SDR) family yqjQ - - ko:K07124 - - - - ko00000 - - - adh_short k59_1329493_1 706587.Desti_1756 2.43e-31 124.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_504570_1 243231.GSU0537 3.69e-81 266.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WTPC@28221|Deltaproteobacteria,43TG7@69541|Desulfuromonadales 28221|Deltaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_4 k59_820591_1 1230343.CANP01000050_gene3775 3.08e-144 440.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1JDFS@118969|Legionellales 118969|Legionellales P AcrB/AcrD/AcrF family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_135090_1 713586.KB900536_gene2107 4.1e-81 249.0 COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,1S4UH@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Mut7-C RNAse domain - - - ko:K09122 - - - - ko00000 - - - Mut7-C,Ub-Mut7C k59_1384900_1 765912.Thimo_3379 2.92e-77 241.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1WWWV@135613|Chromatiales 135613|Chromatiales M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK k59_1651256_1 545264.KB898754_gene1840 6.25e-94 292.0 COG2271@1|root,COG2271@2|Bacteria,1QUF4@1224|Proteobacteria,1RPSF@1236|Gammaproteobacteria,1WWNP@135613|Chromatiales 135613|Chromatiales G PFAM Major Facilitator Superfamily - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_1651256_2 396588.Tgr7_0109 5.24e-102 302.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Exodeoxyribonuclease III crc - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_1234303_1 686340.Metal_3955 4.9e-81 251.0 COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1XEER@135618|Methylococcales 135618|Methylococcales S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_135102_1 1318628.MARLIPOL_09019 4.49e-33 130.0 COG0845@1|root,COG0845@2|Bacteria,1PDUT@1224|Proteobacteria,1RQKD@1236|Gammaproteobacteria,4665P@72275|Alteromonadaceae 1236|Gammaproteobacteria M HlyD family secretion protein - - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - HlyD_3,HlyD_D23,OEP k59_916792_1 563192.HMPREF0179_03464 1.46e-51 185.0 COG5108@1|root,COG5108@2|Bacteria,1PIWB@1224|Proteobacteria,42YXG@68525|delta/epsilon subdivisions,2WU1V@28221|Deltaproteobacteria,2M9ED@213115|Desulfovibrionales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase - - - - - - - - - - - - RNA_pol,RPOL_N k59_342208_1 1121943.KB899996_gene541 6.77e-21 102.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XHGD@135619|Oceanospirillales 135619|Oceanospirillales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_8,PAS_9,Response_reg k59_758670_2 935261.JAGL01000001_gene1806 1.07e-07 55.1 COG2146@1|root,COG2146@2|Bacteria,1RAKS@1224|Proteobacteria,2U5KH@28211|Alphaproteobacteria,43MBZ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_758670_3 460265.Mnod_7596 5.85e-69 224.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2U4DT@28211|Alphaproteobacteria,1JQUY@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_863714_1 1123504.JQKD01000045_gene2105 2.9e-91 286.0 COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VI39@28216|Betaproteobacteria,4AJ2P@80864|Comamonadaceae 28216|Betaproteobacteria EH Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_916809_1 7070.TC003810-PA 7.01e-10 59.3 COG0647@1|root,KOG3040@2759|Eukaryota,38BE9@33154|Opisthokonta,3BAPU@33208|Metazoa,3CVT9@33213|Bilateria,41Y91@6656|Arthropoda,3SK1K@50557|Insecta 33208|Metazoa G Haloacid dehalogenase-like hydrolase domain-containing protein HDHD2 GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0010941,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019899,GO:0042578,GO:0042981,GO:0043067,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007,GO:2000269 - - - - - - - - - - Hydrolase_6,Hydrolase_like,Yos1 k59_504613_1 63737.Npun_F5467 1.41e-59 208.0 COG2202@1|root,COG3852@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3852@2|Bacteria,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria,1HTQ5@1161|Nostocales 1117|Cyanobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - CHASE4,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_290031_1 68570.DC74_1106 9.96e-118 350.0 COG1960@1|root,COG1960@2|Bacteria,2ICK3@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1541194_1 176946.XP_007438332.1 1.85e-80 254.0 COG1960@1|root,KOG0140@2759|Eukaryota,38BNR@33154|Opisthokonta,3BCJM@33208|Metazoa,3CV7W@33213|Bilateria,484GK@7711|Chordata,4905F@7742|Vertebrata 33208|Metazoa I acyl-CoA dehydrogenase ACADM GO:0000062,GO:0000166,GO:0000271,GO:0001889,GO:0003674,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006082,GO:0006091,GO:0006109,GO:0006111,GO:0006112,GO:0006575,GO:0006577,GO:0006578,GO:0006629,GO:0006631,GO:0006635,GO:0006807,GO:0006950,GO:0007275,GO:0007507,GO:0007584,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009062,GO:0009250,GO:0009266,GO:0009409,GO:0009437,GO:0009605,GO:0009628,GO:0009719,GO:0009725,GO:0009791,GO:0009888,GO:0009889,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010675,GO:0010906,GO:0014070,GO:0014706,GO:0015980,GO:0016020,GO:0016042,GO:0016043,GO:0016051,GO:0016054,GO:0016491,GO:0016604,GO:0016607,GO:0016627,GO:0016853,GO:0017076,GO:0019216,GO:0019222,GO:0019254,GO:0019395,GO:0019752,GO:0022607,GO:0030154,GO:0030258,GO:0030424,GO:0030554,GO:0031090,GO:0031323,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033692,GO:0033993,GO:0034440,GO:0034637,GO:0034641,GO:0034645,GO:0035051,GO:0036094,GO:0042221,GO:0042398,GO:0042493,GO:0042594,GO:0042692,GO:0042802,GO:0042995,GO:0043005,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043436,GO:0043933,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0045329,GO:0046395,GO:0046688,GO:0048037,GO:0048513,GO:0048545,GO:0048731,GO:0048732,GO:0048738,GO:0048856,GO:0048869,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051146,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0051791,GO:0051793,GO:0055007,GO:0055114,GO:0060537,GO:0061008,GO:0061061,GO:0062012,GO:0065003,GO:0065007,GO:0070013,GO:0070991,GO:0071704,GO:0071840,GO:0072329,GO:0072359,GO:0080090,GO:0097159,GO:0097164,GO:0097367,GO:0097458,GO:0120025,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901567,GO:1901575,GO:1901576,GO:1901681 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_97480_1 1078020.KEK_00555 1.52e-49 172.0 COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,236P1@1762|Mycobacteriaceae 201174|Actinobacteria L Transposase - - - - - - - - - - - - Transposase_mut k59_673655_1 911045.PSE_0105 6.09e-29 123.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2TRUB@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1508238_1 404589.Anae109_0730 2.28e-18 89.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria,2YUDZ@29|Myxococcales 28221|Deltaproteobacteria NU Type II and III secretion system protein gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_556831_1 765913.ThidrDRAFT_4556 1.05e-73 229.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,1RPJH@1236|Gammaproteobacteria,1WWU7@135613|Chromatiales 135613|Chromatiales L PFAM Transposase IS200 like - - - - - - - - - - - - Y1_Tnp k59_1600865_1 390989.JOEG01000006_gene889 6.57e-13 70.5 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - - - ko:K16648,ko:K20444 - - - - ko00000,ko01000,ko01003,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_tranf_2_3,Glycos_transf_2,Methyltransf_11,NTP_transf_5 k59_1508254_1 207954.MED92_03093 7.76e-31 115.0 COG4122@1|root,COG4122@2|Bacteria,1RB34@1224|Proteobacteria,1S02F@1236|Gammaproteobacteria,1XIIY@135619|Oceanospirillales 135619|Oceanospirillales S PFAM O-methyltransferase, family 3 - - 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_3 k59_1179794_1 479432.Sros_2833 9.38e-50 167.0 COG0307@1|root,COG0307@2|Bacteria,2GKC5@201174|Actinobacteria,4EIPZ@85012|Streptosporangiales 201174|Actinobacteria H Lumazine binding domain ribE GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_1661546_1 1267534.KB906763_gene1179 7.74e-28 112.0 COG1028@1|root,COG1028@2|Bacteria,3Y99R@57723|Acidobacteria 57723|Acidobacteria IQ Fungal family of unknown function (DUF1776) - - - - - - - - - - - - adh_short k59_1082442_1 1537994.JQFW01000049_gene2524 2.14e-18 91.7 COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,1RQAI@1236|Gammaproteobacteria,469WE@72275|Alteromonadaceae 1236|Gammaproteobacteria H Carbohydrate family 9 binding domain-like - - - - - - - - - - - - CBM9_1 k59_350955_1 986075.CathTA2_1020 1.73e-06 53.5 COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,4H9Y2@91061|Bacilli 91061|Bacilli V Mate efflux family protein norN - - - - - - - - - - - MatE k59_350955_2 1118153.MOY_06765 2.61e-27 109.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria,1XH7J@135619|Oceanospirillales 135619|Oceanospirillales IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_556856_1 436308.Nmar_1589 2.73e-10 56.6 arCOG10591@1|root,arCOG10591@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_556856_2 436308.Nmar_1588 2.05e-85 259.0 COG0109@1|root,arCOG00479@2157|Archaea,41SFH@651137|Thaumarchaeota 651137|Thaumarchaeota H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group - - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_870585_1 936455.KI421499_gene1371 9.86e-26 106.0 COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2TRZ0@28211|Alphaproteobacteria,3JU4R@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GFO_IDH_MocA,NAD_binding_3,SAF k59_243907_1 1120999.JONM01000007_gene1727 2.7e-65 223.0 COG5373@1|root,COG5373@2|Bacteria,1N08V@1224|Proteobacteria,2VKJT@28216|Betaproteobacteria,2KQ7I@206351|Neisseriales 206351|Neisseriales S Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - DUF2339 k59_143451_1 765910.MARPU_05210 4.82e-13 74.7 COG0367@1|root,COG0367@2|Bacteria,1PRFK@1224|Proteobacteria,1RNBE@1236|Gammaproteobacteria,1WW7I@135613|Chromatiales 135613|Chromatiales E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_925892_1 331869.BAL199_30097 3.22e-11 62.8 COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,2TRRJ@28211|Alphaproteobacteria,4BPZD@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Binding-protein-dependent transport system inner membrane component - - - ko:K11070,ko:K11074 ko02010,map02010 M00299,M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1,3.A.1.11.2 - - BPD_transp_1 k59_925892_2 1469245.JFBG01000030_gene1533 5.9e-80 244.0 COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,1RNNZ@1236|Gammaproteobacteria,1WW3Y@135613|Chromatiales 135613|Chromatiales E PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K11071,ko:K11075 ko02010,map02010 M00299,M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1,3.A.1.11.2 - - BPD_transp_1 k59_1082447_1 404589.Anae109_2025 2.42e-86 274.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2WINJ@28221|Deltaproteobacteria,2YUJ3@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_1508285_1 1232410.KI421412_gene169 7.73e-83 256.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NQ1@68525|delta/epsilon subdivisions,2X5KW@28221|Deltaproteobacteria,43SYA@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_143456_2 987059.RBXJA2T_12367 1.52e-36 137.0 COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2VI8B@28216|Betaproteobacteria,1KJ6G@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress hslO - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 k59_1300712_1 1282876.BAOK01000001_gene3029 1.88e-77 245.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2U1DI@28211|Alphaproteobacteria,4BS5X@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G MFS/sugar transport protein - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_673735_1 1511.CLOST_1165 5.01e-36 134.0 COG0685@1|root,COG0685@2|Bacteria,1UHX4@1239|Firmicutes,25E62@186801|Clostridia,25R45@186804|Peptostreptococcaceae 186801|Clostridia E Methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_1450836_1 765912.Thimo_1173 5.15e-71 229.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1WWG8@135613|Chromatiales 135613|Chromatiales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_1509711_1 1047013.AQSP01000120_gene936 5.69e-47 171.0 COG4354@1|root,COG4354@2|Bacteria,2NQ9B@2323|unclassified Bacteria 2|Bacteria G beta-glucosidase 2, glycosyl-hydrolase family 116 N-term - - - - - - - - - - - - DUF608,Glyco_hydr_116N k59_1336891_1 1166018.FAES_4806 2.35e-24 103.0 COG0657@1|root,COG0657@2|Bacteria,4NHDX@976|Bacteroidetes,47KJB@768503|Cytophagia 976|Bacteroidetes I Carboxylesterase family - - - - - - - - - - - - Abhydrolase_3,COesterase k59_1302162_1 1049564.TevJSym_ae00650 1.72e-106 314.0 COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,1RQJQ@1236|Gammaproteobacteria,1J5P9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_1450840_1 1430440.MGMSRv2_3796 3.87e-47 163.0 COG3677@1|root,COG3677@2|Bacteria 2|Bacteria L transposition, DNA-mediated - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_832317_1 768671.ThimaDRAFT_1929 6.15e-63 208.0 COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,1RQA2@1236|Gammaproteobacteria,1WYPQ@135613|Chromatiales 135613|Chromatiales L PFAM Integrase catalytic - - - - - - - - - - - - rve k59_832317_2 379731.PST_3410 4.05e-25 100.0 COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,1RNUA@1236|Gammaproteobacteria,1Z0CJ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L ISPsy14, transposition helper protein - - - - - - - - - - - - IstB_IS21,IstB_IS21_ATP k59_1450850_1 87626.PTD2_09983 2.46e-43 159.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2Q0SH@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T HAMP domain GGDEF domain EAL - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS_9,dCache_3 k59_871570_1 448385.sce5871 1.33e-204 607.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,2YX1T@29|Myxococcales 28221|Deltaproteobacteria H Methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_1509738_1 685727.REQ_43650 3.38e-75 234.0 COG1028@1|root,COG1028@2|Bacteria,2GMF5@201174|Actinobacteria,4FYXK@85025|Nocardiaceae 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_609420_1 1123392.AQWL01000005_gene2869 1.03e-76 249.0 COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,2VHGG@28216|Betaproteobacteria,1KTGE@119069|Hydrogenophilales 119069|Hydrogenophilales M Glycosyl transferase family 21 - - - - - - - - - - - - - k59_457406_1 335659.S23_15760 2.4e-08 54.7 COG5424@1|root,COG5424@2|Bacteria,1MW7G@1224|Proteobacteria,2TSQT@28211|Alphaproteobacteria,3JREV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ pqqC - 1.3.3.11 ko:K06136,ko:K06137 - - - - ko00000,ko01000 - - - TENA_THI-4 k59_975578_1 190650.CC_1638 5.79e-28 115.0 COG2303@1|root,COG2303@2|Bacteria,1MXUT@1224|Proteobacteria 1224|Proteobacteria E (GMC) oxidoreductase - - - - - - - - - - - - DAO,DUF1080,FAD_binding_2,FAD_binding_3,GMC_oxred_C,GMC_oxred_N k59_299904_1 1219065.VPR01S_07_01820 8.93e-24 93.6 COG0346@1|root,COG0346@2|Bacteria,1N2SB@1224|Proteobacteria,1SA4P@1236|Gammaproteobacteria,1XY9F@135623|Vibrionales 135623|Vibrionales E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase k59_299904_2 580332.Slit_2196 3.53e-26 101.0 2EJUZ@1|root,333IS@2|Bacteria,1NFIG@1224|Proteobacteria,2VWAA@28216|Betaproteobacteria 28216|Betaproteobacteria S Putative prokaryotic signal transducing protein - - - - - - - - - - - - DUF2007 k59_1450857_1 203122.Sde_0739 1.4e-41 151.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,4658B@72275|Alteromonadaceae 1236|Gammaproteobacteria M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_1336914_1 1041522.MCOL_V213465 2.72e-59 205.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,233NX@1762|Mycobacteriaceae 201174|Actinobacteria C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 k59_675208_1 413816.BBJP01000027_gene1834 2.88e-29 121.0 COG0145@1|root,arCOG01511@2157|Archaea,2XT1J@28890|Euryarchaeota,23SV5@183963|Halobacteria 183963|Halobacteria E COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit hyuA1 - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_1542247_1 998674.ATTE01000001_gene472 1.13e-26 110.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,4606K@72273|Thiotrichales 72273|Thiotrichales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_766525_1 485918.Cpin_4472 1.5e-99 299.0 COG0451@1|root,COG0451@2|Bacteria,4NMWC@976|Bacteroidetes,1ISAA@117747|Sphingobacteriia 976|Bacteroidetes GM epimerase yeeZ - - - - - - - - - - - NAD_binding_10,NAD_binding_2 k59_1302207_1 314254.OA2633_14056 5.91e-67 207.0 COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2U6ZN@28211|Alphaproteobacteria,43XJN@69657|Hyphomonadaceae 28211|Alphaproteobacteria O Peroxiredoxin MA20_20905 - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - Redoxin k59_1302207_2 344747.PM8797T_32350 3.78e-36 132.0 COG0463@1|root,COG0463@2|Bacteria,2IWST@203682|Planctomycetes 203682|Planctomycetes M PFAM Glycosyl transferase family 2 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 k59_1027995_1 1121935.AQXX01000109_gene476 1.03e-29 114.0 COG0607@1|root,COG0607@2|Bacteria,1RM2N@1224|Proteobacteria,1S8IB@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_98614_2 381666.H16_B2405 3.53e-14 67.8 COG2329@1|root,COG2329@2|Bacteria,1RGVV@1224|Proteobacteria,2VUVA@28216|Betaproteobacteria,1K644@119060|Burkholderiaceae 28216|Betaproteobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_871593_1 1121405.dsmv_2119 1.84e-87 284.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MIDR@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-3 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_352061_1 626887.J057_02250 1.12e-10 68.2 COG1807@1|root,COG1807@2|Bacteria,1MXH5@1224|Proteobacteria,1RSQE@1236|Gammaproteobacteria,464KM@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - PMT_2 k59_299925_1 1121405.dsmv_2561 4.37e-31 119.0 COG0834@1|root,COG0834@2|Bacteria,1MWDK@1224|Proteobacteria,42NVT@68525|delta/epsilon subdivisions,2WIRY@28221|Deltaproteobacteria,2MI8X@213118|Desulfobacterales 28221|Deltaproteobacteria ET SMART ABC-type transporter, periplasmic subunit family 3, ionotropic glutamate receptor - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_144302_1 316274.Haur_0997 1.23e-98 303.0 COG1262@1|root,COG1262@2|Bacteria,2G89M@200795|Chloroflexi 200795|Chloroflexi S Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - DinB_2,FGE-sulfatase k59_1542261_1 1357423.S5M6S7_9CAUD 3.92e-18 92.0 4QEE7@10239|Viruses,4QV59@35237|dsDNA viruses no RNA stage,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae 10662|Myoviridae S Pfam:DUF4815 - - - - - - - - - - - - - k59_1083514_1 396588.Tgr7_2795 2.82e-20 85.5 COG0346@1|root,COG0346@2|Bacteria,1RIR2@1224|Proteobacteria,1S7P4@1236|Gammaproteobacteria 1236|Gammaproteobacteria E glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_1509791_2 1279017.AQYJ01000024_gene1068 1.89e-12 69.7 28H8Z@1|root,2Z7KS@2|Bacteria,1MW9T@1224|Proteobacteria,1RQV1@1236|Gammaproteobacteria,465P3@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF1282) - - - - - - - - - - - - DUF1282 k59_1028014_1 883.DvMF_2038 3.4e-59 201.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2M7Y4@213115|Desulfovibrionales 28221|Deltaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_1450885_1 742738.HMPREF9460_03296 7.45e-56 187.0 COG1735@1|root,COG1735@2|Bacteria,1TS8I@1239|Firmicutes,249N0@186801|Clostridia,26B8Z@186813|unclassified Clostridiales 186801|Clostridia S Phosphotriesterase family - - - ko:K07048 - - - - ko00000 - - - PTE k59_98639_1 1085623.GNIT_2998 6.61e-18 82.8 29GYT@1|root,303WG@2|Bacteria,1RET9@1224|Proteobacteria,1TAPK@1236|Gammaproteobacteria,46BMF@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_766552_1 314345.SPV1_06039 1.34e-19 89.7 2E15V@1|root,32WKS@2|Bacteria,1N30I@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_975620_1 1387312.BAUS01000002_gene1022 1.7e-41 152.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VP8B@28216|Betaproteobacteria,2KM89@206350|Nitrosomonadales 206350|Nitrosomonadales EH Anthranilate synthase component I - - 2.6.1.85 ko:K01665 ko00790,map00790 - R01716 RC00010,RC01418 ko00000,ko00001,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_457443_1 1122603.ATVI01000012_gene1216 1.83e-26 102.0 COG0848@1|root,COG0848@2|Bacteria,1RHQ3@1224|Proteobacteria,1S7BK@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Biopolymer transport protein ExbD/TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_457443_2 1122604.JONR01000015_gene139 7.34e-30 110.0 COG0811@1|root,COG0811@2|Bacteria,1MX60@1224|Proteobacteria,1RRX1@1236|Gammaproteobacteria,1X7KH@135614|Xanthomonadales 135614|Xanthomonadales U MotA/TolQ/ExbB proton channel family - - - - - - - - - - - - MotA_ExbB k59_144323_1 485915.Dret_0311 2.75e-77 254.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,2M7ZN@213115|Desulfovibrionales 28221|Deltaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_1392387_2 522373.Smlt3326 5.52e-29 110.0 COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,1S2XX@1236|Gammaproteobacteria,1XC5X@135614|Xanthomonadales 135614|Xanthomonadales S synthesis repressor, PhaR phaR - - - - - - - - - - - PHB_acc,PHB_acc_N k59_98656_1 436308.Nmar_0290 1.32e-43 151.0 COG3875@1|root,arCOG02046@2157|Archaea,41SK4@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF2088) - - - - - - - - - - - - - k59_98656_2 436308.Nmar_0291 1.05e-106 317.0 COG0750@1|root,arCOG00609@2157|Archaea,41S8V@651137|Thaumarchaeota 651137|Thaumarchaeota M Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 k59_516401_1 1234595.C725_0560 2.81e-43 160.0 COG0668@1|root,COG4221@1|root,COG0668@2|Bacteria,COG4221@2|Bacteria,1MXD2@1224|Proteobacteria,2TV7R@28211|Alphaproteobacteria 28211|Alphaproteobacteria M mechanosensitive ion channel - - - ko:K16052,ko:K22044 - - - - ko00000,ko02000 1.A.23.3,1.A.23.4 - - MS_channel k59_717111_1 439235.Dalk_0565 1.8e-99 308.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2MHS6@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1601713_1 2340.JV46_26220 5.38e-79 248.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1J4U5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iJN746.PP_0436 S4,tRNA-synt_1b k59_1450907_1 357808.RoseRS_2336 1.67e-09 62.8 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_1450907_2 768671.ThimaDRAFT_3471 1.41e-59 192.0 COG0463@1|root,COG0463@2|Bacteria,1MXC1@1224|Proteobacteria,1RRHP@1236|Gammaproteobacteria,1WXRS@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_245077_1 935845.JADQ01000023_gene312 0.000888 47.4 COG5002@1|root,COG5002@2|Bacteria,1TPVJ@1239|Firmicutes,4HDDP@91061|Bacilli,26R8V@186822|Paenibacillaceae 91061|Bacilli T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1243565_1 366602.Caul_5423 9.61e-182 513.0 COG3415@1|root,COG3415@2|Bacteria,1QWK4@1224|Proteobacteria,2TX0C@28211|Alphaproteobacteria 28211|Alphaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - DDE_3,HTH_23,HTH_29,HTH_32 k59_1336976_1 497321.C664_03585 3.56e-57 204.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,2KVQM@206389|Rhodocyclales 206389|Rhodocyclales S DNA internalization-related competence protein ComEC Rec2 - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_726595_1 436308.Nmar_1385 7.78e-36 131.0 COG0731@1|root,arCOG00953@2157|Archaea 2157|Archaea C Radical SAM domain protein rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM k59_1348462_1 710685.MycrhN_5168 4.59e-81 262.0 COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,23761@1762|Mycobacteriaceae 201174|Actinobacteria I Biotin carboxylase - - 6.4.1.3,6.4.1.4 ko:K01965,ko:K01968 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00036,M00373,M00741 R01859,R04138 RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1348462_2 465541.ATCJ01000005_gene3892 4.5e-101 309.0 COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria 201174|Actinobacteria I Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta accD2 - - - - - - - - - - - Carboxyl_trans k59_22388_1 697282.Mettu_3580 1.78e-35 127.0 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,1RS0S@1236|Gammaproteobacteria,1XDU4@135618|Methylococcales 135618|Methylococcales F Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine - - 2.4.2.44 ko:K19696 ko00270,ko01100,map00270,map01100 - R09668 RC00063 ko00000,ko00001,ko01000 - - - PNP_UDP_1 k59_22388_2 765911.Thivi_2059 4.6e-83 258.0 2C7Q9@1|root,2Z96K@2|Bacteria,1MWKA@1224|Proteobacteria,1RYMW@1236|Gammaproteobacteria,1WWWK@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_312046_1 90813.JQMT01000001_gene2101 1.22e-93 300.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,45ZT1@72273|Thiotrichales 72273|Thiotrichales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_200274_2 999419.HMPREF1077_02030 6.63e-12 64.7 COG1595@1|root,COG1595@2|Bacteria,4NSVA@976|Bacteroidetes,2FMT6@200643|Bacteroidia,22Y4K@171551|Porphyromonadaceae 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1554729_1 458817.Shal_3400 2.03e-05 50.1 COG0810@1|root,COG0810@2|Bacteria,1QB3I@1224|Proteobacteria,1T6MD@1236|Gammaproteobacteria,2QBIR@267890|Shewanellaceae 1236|Gammaproteobacteria M TIGRFAM TonB family protein - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_415205_1 338963.Pcar_1714 3.37e-41 155.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,43S9Z@69541|Desulfuromonadales 28221|Deltaproteobacteria P AcrB/AcrD/AcrF family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_469428_1 1198232.CYCME_1266 6.92e-47 160.0 COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,1RYD7@1236|Gammaproteobacteria,460JY@72273|Thiotrichales 72273|Thiotrichales O May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ate - 2.3.2.29 ko:K21420 - - R11547,R11548 RC00064 ko00000,ko01000 - - - ATE_C,ATE_N k59_568822_1 247634.GPB2148_3287 5.62e-68 218.0 COG2141@1|root,COG2141@2|Bacteria,1R76K@1224|Proteobacteria 1224|Proteobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_985986_1 396588.Tgr7_0764 2.37e-10 61.2 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,1WX75@135613|Chromatiales 135613|Chromatiales M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_985986_2 637390.AFOH01000117_gene2727 4.29e-44 158.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,2NCE5@225057|Acidithiobacillales 225057|Acidithiobacillales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1348487_1 292415.Tbd_2044 1.13e-80 270.0 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,2VJSM@28216|Betaproteobacteria,1KRHF@119069|Hydrogenophilales 119069|Hydrogenophilales P Putative metal-binding domain of cation transport ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_1192308_1 118161.KB235922_gene5609 1.32e-51 183.0 COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,3VI6G@52604|Pleurocapsales 1117|Cyanobacteria T diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_7,PAS_8,PAS_9,Response_reg k59_882399_1 1476583.DEIPH_ctg040orf0054 4.1e-23 103.0 COG3383@1|root,COG3383@2|Bacteria,1WJDD@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C TIGRFAM formate dehydrogenase, alpha subunit, archaeal-type - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_939153_1 251229.Chro_4650 6.49e-27 112.0 COG0531@1|root,COG0531@2|Bacteria,1G2GM@1117|Cyanobacteria,3VINB@52604|Pleurocapsales 1117|Cyanobacteria E Amino acid polyamine organocation transporter, APC superfamily - - - - - - - - - - - - - k59_568866_1 643562.Daes_0699 1.11e-21 99.4 COG0451@1|root,COG0451@2|Bacteria,1NEDD@1224|Proteobacteria,42QH7@68525|delta/epsilon subdivisions,2WIME@28221|Deltaproteobacteria,2MDGB@213115|Desulfovibrionales 28221|Deltaproteobacteria GM ADP-glyceromanno-heptose 6-epimerase activity - - - - - - - - - - - - - k59_882404_1 1286632.P278_07160 4.16e-15 79.3 28HMZ@1|root,2Z7WD@2|Bacteria,4NYC4@976|Bacteroidetes,1IBH2@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_939174_1 1229909.NSED_08215 9.62e-42 138.0 arCOG08641@1|root,arCOG08641@2157|Archaea,41SU7@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_939174_2 436308.Nmar_1492 1.62e-14 74.7 arCOG03272@1|root,arCOG03272@2157|Archaea 436308.Nmar_1492|- - - - - - - - - - - - - - - - k59_415293_1 365046.Rta_31050 1.55e-19 93.2 COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2VIZ1@28216|Betaproteobacteria,4AB04@80864|Comamonadaceae 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_312141_1 1089553.Tph_c08220 3.89e-62 210.0 COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42ERP@68295|Thermoanaerobacterales 186801|Clostridia C Aldehyde ferredoxin oxidoreductase aor - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS09915 AFOR_C,AFOR_N k59_882412_1 266117.Rxyl_0428 8.14e-11 61.2 COG5588@1|root,COG5588@2|Bacteria,2HIPH@201174|Actinobacteria,4CTK9@84995|Rubrobacteria 84995|Rubrobacteria S Protein of unknown function (DUF1326) - - - - - - - - - - - - DUF1326 k59_882412_2 1547437.LL06_12630 2.19e-28 117.0 COG5486@1|root,COG5486@2|Bacteria,1NFSK@1224|Proteobacteria,2U9E0@28211|Alphaproteobacteria,43IJ2@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Predicted metal-binding integral membrane protein (DUF2182) - - - - - - - - - - - - DUF2182 k59_986058_1 1049564.TevJSym_cl00010 1.18e-80 256.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1J5GM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1,Thioredoxin_4 k59_415296_1 1123368.AUIS01000024_gene955 3.55e-61 196.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,2NBTX@225057|Acidithiobacillales 225057|Acidithiobacillales L Endonuclease/Exonuclease/phosphatase family - - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_469514_3 517417.Cpar_1521 6.01e-49 161.0 COG0758@1|root,COG0758@2|Bacteria,1FE5W@1090|Chlorobi 1090|Chlorobi LU Putative molybdenum carrier - - - - - - - - - - - - MoCo_carrier k59_622438_1 1101190.ARWB01000001_gene3188 4.04e-15 79.0 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,2TT7B@28211|Alphaproteobacteria,36Y1H@31993|Methylocystaceae 28211|Alphaproteobacteria P Inositol monophosphatase family cysQ - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_155859_2 268746.Q58M84_BPPRM 5.26e-61 195.0 4QCVH@10239|Viruses,4QRHW@28883|Caudovirales,4QJX6@10662|Myoviridae 10662|Myoviridae S Glycosyltransferase family 25 (LPS biosynthesis protein) - - - - - - - - - - - - - k59_1348590_1 1382356.JQMP01000003_gene2043 1.26e-92 298.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2G5ZQ@200795|Chloroflexi,27XZV@189775|Thermomicrobia 189775|Thermomicrobia C FAD linked oxidases, C-terminal domain - - - - - - - - - - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17 k59_255897_1 207954.MED92_07006 5.72e-65 218.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1XHNV@135619|Oceanospirillales 135619|Oceanospirillales C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_1095665_1 981085.XP_010112100.1 2.37e-08 56.6 COG0227@1|root,KOG3278@2759|Eukaryota,37SJW@33090|Viridiplantae,3G88E@35493|Streptophyta,4JMYP@91835|fabids 35493|Streptophyta J ribosomal protein - - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k59_1095665_2 1445613.JALM01000048_gene3074 3.72e-25 96.7 COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,4E5HR@85010|Pseudonocardiales 201174|Actinobacteria J Ribosomal protein L31 rpmE2 - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_1095665_3 391625.PPSIR1_09036 2.81e-36 125.0 COG0199@1|root,COG0199@2|Bacteria,1PDMJ@1224|Proteobacteria,42VCE@68525|delta/epsilon subdivisions,2WR7W@28221|Deltaproteobacteria,2Z1V1@29|Myxococcales 28221|Deltaproteobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_986080_1 696281.Desru_1655 5.52e-07 56.6 COG1664@1|root,COG1664@2|Bacteria,1V1NS@1239|Firmicutes,24TEV@186801|Clostridia 186801|Clostridia M Polymer-forming cytoskeletal - - - - - - - - - - - - - k59_363890_1 381666.H16_A1382 5.75e-64 207.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VJ0T@28216|Betaproteobacteria,1K1E6@119060|Burkholderiaceae 28216|Betaproteobacteria BQ histone deacetylase acuC - - - - - - - - - - - Hist_deacetyl k59_155887_1 436308.Nmar_0290 3.84e-69 219.0 COG3875@1|root,arCOG02046@2157|Archaea,41SK4@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF2088) - - - - - - - - - - - - - k59_622473_1 909663.KI867150_gene2148 4.24e-21 102.0 COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MQ8R@213462|Syntrophobacterales 28221|Deltaproteobacteria I BadF BadG BcrA BcrD - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_363899_1 1229909.NSED_01420 2.85e-77 237.0 COG2520@1|root,arCOG00033@2157|Archaea,41S7P@651137|Thaumarchaeota 651137|Thaumarchaeota J Met-10+ like-protein - - 2.1.1.228 ko:K15429 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - Met_10 k59_363899_2 436308.Nmar_0295 3e-52 179.0 COG1245@1|root,arCOG00187@2157|Archaea,41S8K@651137|Thaumarchaeota 651137|Thaumarchaeota E RNase L inhibitor, RLI - - - ko:K06174 - - - - ko00000,ko03009 - - - ABC_tran,Fer4,RLI k59_986108_1 76869.PputGB1_3728 6.14e-39 147.0 COG1232@1|root,COG1232@2|Bacteria,1QTUF@1224|Proteobacteria,1T1HM@1236|Gammaproteobacteria 1236|Gammaproteobacteria H NAD(P)-binding Rossmann-like domain spdH - 1.5.99.6 ko:K00316 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R01914,R01915 RC00053,RC00225 ko00000,ko00001,ko01000 - - - NAD_binding_8 k59_363905_1 180281.CPCC7001_2662 1.69e-25 107.0 COG3637@1|root,COG3637@2|Bacteria,1G4TB@1117|Cyanobacteria 1117|Cyanobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_1095710_2 1229909.NSED_07875 1.44e-41 138.0 COG3432@1|root,arCOG01055@2157|Archaea,41SST@651137|Thaumarchaeota 651137|Thaumarchaeota K Winged helix-turn-helix - - - - - - - - - - - - HTH_45 k59_777070_1 1123060.JONP01000006_gene4738 3.33e-14 76.6 COG0596@1|root,COG0596@2|Bacteria,1MW2P@1224|Proteobacteria,2TSS3@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Alpha beta hydrolase MA20_32265 - 1.11.1.10 ko:K00433 - - - - ko00000,ko01000 - - - Abhydrolase_1 k59_363936_1 1249627.D779_0882 1.53e-118 351.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1WVZ2@135613|Chromatiales 135613|Chromatiales E TIGRFAM glutamine synthetase, type I glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_728002_1 870187.Thini_2511 1.01e-32 130.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,46000@72273|Thiotrichales 72273|Thiotrichales P TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_986168_1 1229909.NSED_02195 6.57e-97 295.0 COG0065@1|root,arCOG01698@2157|Archaea,41SYT@651137|Thaumarchaeota 651137|Thaumarchaeota E 3-isopropylmalate dehydratase, large subunit - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_568976_1 637905.SVI_0129 2.66e-43 162.0 COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,1RPJ6@1236|Gammaproteobacteria,2QEK7@267890|Shewanellaceae 1236|Gammaproteobacteria M Cellulose synthase bcsA GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016020,GO:0016051,GO:0030243,GO:0030244,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0051273,GO:0051274,GO:0071704,GO:0071944,GO:0090540,GO:1901576 2.4.1.12 ko:K00694,ko:K20541 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - Cellulose_synt,Glyco_hydro_17,Glyco_tranf_2_3,Glycos_transf_2,PilZ k59_22470_2 309801.trd_0443 1.53e-08 55.8 COG0542@1|root,COG0542@2|Bacteria,2G5QU@200795|Chloroflexi,27XEJ@189775|Thermomicrobia 189775|Thermomicrobia O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1348741_2 243090.RB7678 2.58e-43 149.0 COG3485@1|root,COG3485@2|Bacteria,2IYBV@203682|Planctomycetes 203682|Planctomycetes Q protocatechuate 3,4-dioxygenase, beta subunit - - 1.13.11.3 ko:K00449 ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220 - R01631,R03549 RC00388,RC00953 br01602,ko00000,ko00001,ko01000 - - - Dioxygenase_C k59_777113_1 1283300.ATXB01000001_gene328 4.96e-09 54.3 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,1XF5B@135618|Methylococcales 135618|Methylococcales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_777113_2 1121937.AUHJ01000005_gene2232 1.51e-97 292.0 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,46491@72275|Alteromonadaceae 1236|Gammaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease dnaQ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7,3.1.26.4 ko:K02342,ko:K14159 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_H,RNase_T k59_1610609_2 436308.Nmar_1761 1.74e-49 162.0 COG1878@1|root,arCOG02462@2157|Archaea,41SK8@651137|Thaumarchaeota 651137|Thaumarchaeota E Putative cyclase - - - - - - - - - - - - Cyclase k59_312303_1 95619.PM1_0213595 9.93e-49 164.0 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria 1236|Gammaproteobacteria K response regulator - - - - - - - - - - - - GerE,Response_reg k59_1555005_1 1348114.OM33_13165 1.99e-56 190.0 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,1RPEQ@1236|Gammaproteobacteria,2Q15P@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3 k59_1192597_1 330214.NIDE0799 2.61e-110 327.0 COG0304@1|root,COG0304@2|Bacteria,3J0DH@40117|Nitrospirae 40117|Nitrospirae I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_415483_1 1037409.BJ6T_88080 1.05e-25 105.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U1Z0@28211|Alphaproteobacteria,3JW1X@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - 2.7.7.49 ko:K00986,ko:K15342 - - - - ko00000,ko01000,ko02048,ko03400 - - - Cas_Cas1,GIIM,RVT_1 k59_1555024_1 265072.Mfla_1254 6.69e-65 213.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VPRI@28216|Betaproteobacteria,2KKCP@206350|Nitrosomonadales 206350|Nitrosomonadales T PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1192627_1 1229909.NSED_02645 1.07e-45 152.0 COG0727@1|root,arCOG02579@2157|Archaea,41T3E@651137|Thaumarchaeota 651137|Thaumarchaeota S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_1192627_2 1229909.NSED_02650 5.51e-60 186.0 COG0361@1|root,arCOG01179@2157|Archaea,41SRK@651137|Thaumarchaeota 651137|Thaumarchaeota J Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits - - - ko:K03236 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - eIF-1a k59_883308_2 316067.Geob_0795 5.37e-78 244.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,42NRM@68525|delta/epsilon subdivisions,2WJ0S@28221|Deltaproteobacteria,43TCQ@69541|Desulfuromonadales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoH - - ko:K03086,ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_317393_2 118161.KB235918_gene2 2.42e-66 208.0 COG2818@1|root,COG2818@2|Bacteria,1G5Y1@1117|Cyanobacteria,3VM4G@52604|Pleurocapsales 1117|Cyanobacteria L Methyladenine glycosylase - - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_56777_1 204669.Acid345_0610 9.87e-151 436.0 COG1960@1|root,COG1960@2|Bacteria,3Y2FM@57723|Acidobacteria,2JIVG@204432|Acidobacteriia 204432|Acidobacteriia I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_56777_2 690585.JNNU01000009_gene615 3.14e-18 85.5 COG2103@1|root,COG2103@2|Bacteria,1MVDR@1224|Proteobacteria,2TTCF@28211|Alphaproteobacteria,4B78M@82115|Rhizobiaceae 28211|Alphaproteobacteria S Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling murQ - 4.2.1.126 ko:K07106 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - - SIS,SIS_2 k59_56780_1 1122132.AQYH01000007_gene1918 3.13e-09 57.4 COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2TVCS@28211|Alphaproteobacteria,4BCBX@82115|Rhizobiaceae 28211|Alphaproteobacteria S Carbon-nitrogen hydrolase - - 3.5.1.77 ko:K01459 - - - - ko00000,ko01000 - - - CN_hydrolase k59_56780_2 502025.Hoch_3415 1.64e-104 318.0 COG0031@1|root,COG0031@2|Bacteria,1QQKZ@1224|Proteobacteria,42PVJ@68525|delta/epsilon subdivisions,2WKKY@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit - - - - - - - - - - - - PALP k59_1466524_1 1192124.LIG30_4279 4.78e-140 406.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria,1K0WZ@119060|Burkholderiaceae 28216|Betaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - - ko:K00646 - - - - ko00000,ko01008 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1623030_1 330214.NIDE4027 0.000116 43.5 COG1076@1|root,COG1076@2|Bacteria,3J1CS@40117|Nitrospirae 40117|Nitrospirae O DnaJ molecular chaperone homology domain hscB - - ko:K04082 - - - - ko00000,ko03029,ko03110 - - - - k59_1623030_2 330214.NIDE4028 3.1e-115 348.0 COG0443@1|root,COG0443@2|Bacteria,3J0YD@40117|Nitrospirae 40117|Nitrospirae O Hsp70 protein hscA - - ko:K04043,ko:K04044 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33,1.A.33.1 - - HSP70 k59_56785_1 1049564.TevJSym_bc00300 2.58e-92 280.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1J9VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Hydrogenase formation hypA family hypD GO:0003674,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0036211,GO:0042165,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070025,GO:0071704,GO:1901564 - ko:K04654 - - - - ko00000 - - - HypD k59_1413834_1 436308.Nmar_0011 1.7e-104 321.0 COG0464@1|root,arCOG01308@2157|Archaea,41SX8@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48), domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_525970_1 1030157.AFMP01000031_gene2963 8.64e-53 182.0 2DBBP@1|root,2Z88Z@2|Bacteria,1R3B4@1224|Proteobacteria,2TZAY@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_839521_1 713586.KB900536_gene1827 9.58e-282 776.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1WXP7@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase - - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_1100796_1 326442.PSHAa2131 2.92e-57 190.0 COG1960@1|root,COG1960@2|Bacteria,1Q9M0@1224|Proteobacteria,1SXET@1236|Gammaproteobacteria,2Q4P0@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1100796_2 1240350.AMZE01000075_gene4401 5.33e-48 161.0 COG1028@1|root,COG1028@2|Bacteria,1P1U4@1224|Proteobacteria,1RR3M@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_1206011_1 1122134.KB893651_gene2097 9.29e-66 217.0 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1XHVS@135619|Oceanospirillales 135619|Oceanospirillales CP COG0651 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_631443_2 1454004.AW11_01051 4.68e-40 139.0 2CB7M@1|root,31H4T@2|Bacteria,1MYWT@1224|Proteobacteria,2VSTJ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_943639_1 933262.AXAM01000016_gene156 6.74e-33 117.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,42TMU@68525|delta/epsilon subdivisions,2WQ67@28221|Deltaproteobacteria,2MK6N@213118|Desulfobacterales 28221|Deltaproteobacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_943639_2 979556.MTES_3261 4.27e-80 246.0 COG0336@1|root,COG0336@2|Bacteria,2GJ1G@201174|Actinobacteria,4FMFF@85023|Microbacteriaceae 201174|Actinobacteria J Belongs to the RNA methyltransferase TrmD family trmD GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - Acetyltransf_1,tRNA_m1G_MT k59_943639_3 1449353.JQMQ01000005_gene2017 1.22e-15 78.6 COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,2NEBS@228398|Streptacidiphilus 201174|Actinobacteria J RimM N-terminal domain rimM GO:0008150,GO:0040007 - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_995796_1 713586.KB900536_gene3027 1.27e-31 126.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales 135613|Chromatiales L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_891928_1 489825.LYNGBM3L_21150 2.36e-37 140.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glycos_transf_1 k59_1413863_1 1122599.AUGR01000004_gene2139 7.1e-33 130.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0471 Di- and tricarboxylate transporters sac1 - - - - - - - - - - - CitMHS,TrkA_C k59_735044_1 472759.Nhal_0536 4.61e-49 170.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales 135613|Chromatiales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_264974_1 1125973.JNLC01000012_gene1064 2.1e-97 298.0 COG1012@1|root,COG1012@2|Bacteria,1QUBI@1224|Proteobacteria,2TSSD@28211|Alphaproteobacteria,3JSCW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Aldehyde dehydrogenase family adhE - 1.2.1.81,1.2.1.87 ko:K13922,ko:K15515 ko00640,map00640 - R09097 RC00004,RC00184 ko00000,ko00001,ko01000 - - - Aldedh k59_839542_1 1116232.AHBF01000113_gene4566 4.48e-39 142.0 COG2513@1|root,COG2513@2|Bacteria,2GJZZ@201174|Actinobacteria 201174|Actinobacteria G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate - - 5.4.2.9 ko:K01841 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 - R00661 RC02792 ko00000,ko00001,ko01000 - - - PEP_mutase k59_1413867_1 338963.Pcar_2584 1.18e-37 142.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,43S03@69541|Desulfuromonadales 28221|Deltaproteobacteria J Ribonuclease E/G family cafA - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_107827_1 1286106.MPL1_06507 2.33e-102 303.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RM9H@1236|Gammaproteobacteria,460AA@72273|Thiotrichales 72273|Thiotrichales Q ABC transporter permease - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_1258213_1 1123392.AQWL01000002_gene1974 1.08e-32 123.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2VH6N@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_1258213_2 765912.Thimo_2233 3.04e-37 132.0 COG1051@1|root,COG4111@1|root,COG1051@2|Bacteria,COG4111@2|Bacteria,1MXHA@1224|Proteobacteria,1T1QN@1236|Gammaproteobacteria,1WYUW@135613|Chromatiales 135613|Chromatiales F NUDIX domain - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_1413875_1 1229909.NSED_03065 3.62e-91 271.0 COG1938@1|root,arCOG00347@2157|Archaea,41SSA@651137|Thaumarchaeota 651137|Thaumarchaeota S PAC2 family - - - ko:K06869 - - - - ko00000 - - - PAC2 k59_1466568_1 323261.Noc_2396 1.08e-76 238.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,1WWM1@135613|Chromatiales 135613|Chromatiales P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_839559_1 999141.GME_13345 2.35e-33 121.0 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,1XH61@135619|Oceanospirillales 135619|Oceanospirillales J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_839559_2 1123236.KB899377_gene319 6.33e-24 93.6 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,1S8VX@1236|Gammaproteobacteria,467BY@72275|Alteromonadaceae 1236|Gammaproteobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_1100842_1 1245471.PCA10_50010 2.3e-38 149.0 COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,1TBFS@1236|Gammaproteobacteria,1YHD1@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria Q Multicopper oxidase - - 1.16.3.3 ko:K22349 - - - - ko00000,ko01000 - - - - k59_1413885_1 706587.Desti_1543 2.74e-50 177.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MQAN@213462|Syntrophobacterales 28221|Deltaproteobacteria J TIGRFAM ribonuclease, Rne Rng family cafA - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1206074_1 595537.Varpa_2933 2.8e-13 74.3 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VM92@28216|Betaproteobacteria,4ACS4@80864|Comamonadaceae 28216|Betaproteobacteria P Rieske 2Fe-2S domain protein nagG - 1.14.12.1,1.14.13.172 ko:K16319,ko:K18242 ko00626,ko00627,ko01120,map00626,map00627,map01120 M00637,M00638 R00823,R00825,R07709,R07710 RC00192,RC00490 br01602,ko00000,ko00001,ko00002,ko01000 - - - Rieske,Ring_hydroxyl_A k59_526021_1 1232410.KI421415_gene2974 6.06e-133 392.0 COG2170@1|root,COG2170@2|Bacteria,1MY35@1224|Proteobacteria,42PBG@68525|delta/epsilon subdivisions,2WK4S@28221|Deltaproteobacteria,43UJW@69541|Desulfuromonadales 28221|Deltaproteobacteria S Glutamate-cysteine ligase family 2(GCS2) - - - - - - - - - - - - GCS2 k59_421689_1 2340.JV46_12710 9.2e-25 108.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1J4Y8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes sucA GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1309382_1 1198452.Jab_1c06240 1.01e-09 66.2 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,472RR@75682|Oxalobacteraceae 28216|Betaproteobacteria T PFAM EAL domain, GGDEF domain - - - - - - - - - - - - CHASE,EAL,GGDEF,MASE1,PAS,PAS_7,PAS_9,Response_reg k59_1623092_2 391735.Veis_1049 1.22e-153 445.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,4AAWB@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_1413898_1 290397.Adeh_0366 6.89e-90 276.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2WIQU@28221|Deltaproteobacteria,2YTSK@29|Myxococcales 28221|Deltaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1623093_1 1173026.Glo7428_0932 9.56e-28 116.0 COG1216@1|root,COG5309@1|root,COG1216@2|Bacteria,COG5309@2|Bacteria,1G2MT@1117|Cyanobacteria 1117|Cyanobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_hydro_2_C,Glycos_transf_2 k59_265009_1 349124.Hhal_1070 5.48e-167 480.0 COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,1RPQN@1236|Gammaproteobacteria,1WWIP@135613|Chromatiales 135613|Chromatiales S 2-methylcitrate dehydratase prpD - 4.2.1.79 ko:K01720 ko00640,map00640 - R04424 RC01152 ko00000,ko00001,ko01000 - - - MmgE_PrpD k59_265009_2 864051.BurJ1DRAFT_1580 2.59e-29 113.0 COG3495@1|root,COG3495@2|Bacteria,1RFBI@1224|Proteobacteria,2VRJ9@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF3299) - - - ko:K09950 - - - - ko00000 - - - DUF3299 k59_578316_1 1297865.APJD01000036_gene1527 6.97e-70 227.0 COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2TVJ9@28211|Alphaproteobacteria,3JQZ3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1517402_1 518766.Rmar_2012 2.11e-59 203.0 COG4263@1|root,COG4263@2|Bacteria,4NFNE@976|Bacteroidetes,1FIVE@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Nitrous oxide reductase nosZ - 1.7.2.4 ko:K00376 ko00910,ko01120,map00910,map01120 M00529 R02804 RC02861 ko00000,ko00001,ko00002,ko01000 - - - - k59_1206092_1 880072.Desac_0553 3.55e-84 266.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,2MQ97@213462|Syntrophobacterales 28221|Deltaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_265012_1 338963.Pcar_1237 1.83e-16 79.7 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NK7@68525|delta/epsilon subdivisions,2WKTV@28221|Deltaproteobacteria,43RYC@69541|Desulfuromonadales 28221|Deltaproteobacteria C Glu/Leu/Phe/Val dehydrogenase, dimerisation domain - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_265012_2 177439.DP1202 1.55e-76 246.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2MHX9@213118|Desulfobacterales 28221|Deltaproteobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1309402_1 330214.NIDE0853 4.95e-41 145.0 COG4105@1|root,COG4105@2|Bacteria,3J0UU@40117|Nitrospirae 40117|Nitrospirae S Tetratricopeptide repeat - - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_421715_1 240015.ACP_2303 1.17e-26 108.0 COG1233@1|root,COG1233@2|Bacteria,3Y3I8@57723|Acidobacteria,2JI78@204432|Acidobacteriia 204432|Acidobacteriia C TIGRFAM phytoene desaturase - - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 - R04787,R04798,R04800,R09691,R09692 RC01214,RC02088,RC02605 ko00000,ko00001,ko01000 - - - Amino_oxidase k59_421715_2 1238182.C882_1170 1.06e-52 184.0 COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,2TR9T@28211|Alphaproteobacteria,2JVAH@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_891988_1 648996.Theam_0973 3.92e-60 197.0 COG1052@1|root,COG1052@2|Bacteria,2G4IA@200783|Aquificae 200783|Aquificae C D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.28 ko:K03778 ko00620,ko01120,map00620,map01120 - R00704 RC00044 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_107873_1 1244869.H261_13239 3.37e-61 211.0 COG1061@1|root,COG4951@1|root,COG1061@2|Bacteria,COG4951@2|Bacteria,1QVE4@1224|Proteobacteria,2TUH9@28211|Alphaproteobacteria,2JW67@204441|Rhodospirillales 204441|Rhodospirillales L DEAD-like helicases superfamily - - - - - - - - - - - - ResIII k59_107873_2 345341.KUTG_02458 3.76e-07 48.9 2DMB2@1|root,32UGJ@2|Bacteria,2IQ9P@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - Calci_bind_CcbP k59_1467428_1 215803.DB30_0647 3.27e-88 290.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2YUJI@29|Myxococcales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_108588_1 1229909.NSED_01555 6.34e-134 387.0 COG2038@1|root,arCOG04272@2157|Archaea,41SD3@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the UPF0284 family - - - - - - - - - - - - DBI_PRT k59_318338_1 1150469.RSPPHO_01955 6.98e-16 78.6 COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,2TRQC@28211|Alphaproteobacteria,2JPA7@204441|Rhodospirillales 204441|Rhodospirillales I Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) ispDF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB k59_318338_2 1278073.MYSTI_03019 4.18e-20 84.7 COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,42RXS@68525|delta/epsilon subdivisions,2WNA0@28221|Deltaproteobacteria,2YVAI@29|Myxococcales 28221|Deltaproteobacteria K Transcriptional regulator, CarD family - - - ko:K07736 - - - - ko00000,ko03000 - - - CarD_CdnL_TRCF k59_57840_1 1229909.NSED_00020 6.02e-106 313.0 COG2219@1|root,arCOG03013@2157|Archaea,41SCD@651137|Thaumarchaeota 651137|Thaumarchaeota L Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair priL - - ko:K18882 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DNA_primase_lrg k59_1207135_1 570952.ATVH01000017_gene1762 2.51e-63 199.0 COG1765@1|root,COG1765@2|Bacteria,1MWPR@1224|Proteobacteria,2U1VW@28211|Alphaproteobacteria,2JUAQ@204441|Rhodospirillales 204441|Rhodospirillales O OsmC-like protein - - - - - - - - - - - - OsmC k59_474465_1 105559.Nwat_1623 5.97e-50 179.0 COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,1RP7I@1236|Gammaproteobacteria,1WXPY@135613|Chromatiales 135613|Chromatiales H TonB-dependent Receptor Plug - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_735799_1 330214.NIDE4337 1.78e-59 194.0 COG0668@1|root,COG0668@2|Bacteria 2|Bacteria M transmembrane transport - - - - - - - - - - - - MS_channel k59_1362729_1 243233.MCA2758 6.07e-38 149.0 COG1033@1|root,COG1033@2|Bacteria,1QW3H@1224|Proteobacteria,1RZA3@1236|Gammaproteobacteria,1XDIY@135618|Methylococcales 1236|Gammaproteobacteria S TIGRFAM Hopanoid biosynthesis associated RND transporter like protein HpnN - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1414793_1 158500.BV97_04343 2.79e-11 66.6 COG0526@1|root,COG0526@2|Bacteria,1RAW3@1224|Proteobacteria,2UA3X@28211|Alphaproteobacteria,2K2NS@204457|Sphingomonadales 204457|Sphingomonadales CO Prolipoprotein diacylglyceryl transferase - - - - - - - - - - - - LGT,Redoxin k59_1414793_2 243233.MCA1041 4.74e-30 123.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1XDNX@135618|Methylococcales 135618|Methylococcales CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_892761_1 670487.Ocepr_0894 4.8e-77 241.0 COG0483@1|root,COG0483@2|Bacteria,1WIZ7@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G PFAM Inositol monophosphatase family - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_1259258_1 1499967.BAYZ01000008_gene5414 7.98e-59 201.0 COG3379@1|root,COG3379@2|Bacteria,2NQA7@2323|unclassified Bacteria 2|Bacteria S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_632525_1 626418.bglu_2g08960 3.08e-16 84.0 COG5285@1|root,COG5285@2|Bacteria,1MWD5@1224|Proteobacteria,2VVEV@28216|Betaproteobacteria,1KBQE@119060|Burkholderiaceae 28216|Betaproteobacteria C Phytanoyl-CoA dioxygenase (PhyH) - - - - - - - - - - - - PhyH k59_1207151_1 1408254.T458_08960 1.87e-19 91.3 COG1574@1|root,COG2366@1|root,COG1574@2|Bacteria,COG2366@2|Bacteria,1TT7I@1239|Firmicutes,4HAZ1@91061|Bacilli 91061|Bacilli S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_422475_1 395961.Cyan7425_3861 1.1e-34 129.0 COG1409@1|root,COG1409@2|Bacteria,1G32R@1117|Cyanobacteria 1117|Cyanobacteria S Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes cpdA - 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos k59_1467455_1 1121937.AUHJ01000010_gene1712 1.68e-94 296.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,4641A@72275|Alteromonadaceae 1236|Gammaproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_1571322_2 713587.THITH_12955 4.92e-35 130.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_632532_1 67275.JOAP01000015_gene4754 5.11e-74 237.0 COG1012@1|root,COG1012@2|Bacteria,2GJI2@201174|Actinobacteria 201174|Actinobacteria C Dehydrogenase mmsA - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1207158_1 268746.Q58MG6_BPPRM 3.06e-46 152.0 4QAQV@10239|Viruses,4QUPK@35237|dsDNA viruses no RNA stage,4QPCB@28883|Caudovirales,4QHX6@10662|Myoviridae 10662|Myoviridae S hydrolase activity - - - - - - - - - - - - - k59_428378_1 1155718.KB891879_gene4989 2.15e-18 85.1 COG1515@1|root,COG1515@2|Bacteria,2GJEZ@201174|Actinobacteria 201174|Actinobacteria L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA nfi - 3.1.21.7 ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 k59_640156_1 1034943.BN1094_03079 8.23e-122 363.0 COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,1RQ0T@1236|Gammaproteobacteria,1JCMT@118969|Legionellales 118969|Legionellales C Belongs to the Glu Leu Phe Val dehydrogenases family ldh - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_640156_2 472759.Nhal_1213 4.16e-153 442.0 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1RREX@1236|Gammaproteobacteria,1X083@135613|Chromatiales 135613|Chromatiales C 1-deoxy-D-xylulose-5-phosphate synthase - - 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_640156_3 472759.Nhal_1212 2.3e-141 406.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1WXRY@135613|Chromatiales 135613|Chromatiales C Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase - - 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_481196_1 472759.Nhal_2578 6.22e-33 130.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales 135613|Chromatiales Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_1266879_1 1081644.IMCC13023_08690 8.75e-65 221.0 COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4FKQD@85023|Microbacteriaceae 201174|Actinobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090 - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_324541_2 1230343.CANP01000012_gene1052 2.27e-18 82.4 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S8NE@1236|Gammaproteobacteria,1JEDX@118969|Legionellales 118969|Legionellales O Hsp20/alpha crystallin family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_1421332_1 545264.KB898744_gene2248 3.03e-47 155.0 COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,1S61I@1236|Gammaproteobacteria,1WYB4@135613|Chromatiales 135613|Chromatiales J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd - - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_219434_1 1173749.S4TRC9_9CAUD 2.3e-26 112.0 4QAKZ@10239|Viruses,4QYAE@35237|dsDNA viruses no RNA stage,4QPYH@28883|Caudovirales,4QM57@10699|Siphoviridae 10699|Siphoviridae S intein-mediated protein splicing - - - - - - - - - - - - - k59_428400_2 246200.SPO3704 3.9e-36 134.0 COG0703@1|root,COG1396@1|root,COG0703@2|Bacteria,COG1396@2|Bacteria,1MX66@1224|Proteobacteria,2TQWU@28211|Alphaproteobacteria,4NBQ1@97050|Ruegeria 28211|Alphaproteobacteria EK Shikimate kinase - - - ko:K15546 - - - - ko00000,ko03000 - - - HTH_3,SKI k59_691374_1 768671.ThimaDRAFT_3755 3.87e-33 125.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1WWHB@135613|Chromatiales 135613|Chromatiales E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_691374_2 187272.Mlg_1823 6.12e-39 140.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RQBM@1236|Gammaproteobacteria,1WWV0@135613|Chromatiales 135613|Chromatiales E aminotransferase class I and II - - - ko:K14261 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_165107_1 981223.AIED01000057_gene2655 2.66e-73 238.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,3NKKZ@468|Moraxellaceae 1236|Gammaproteobacteria M Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_1315873_1 393595.ABO_0947 1.51e-108 353.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1XH98@135619|Oceanospirillales 135619|Oceanospirillales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1474957_1 506534.Rhein_2074 9.93e-37 142.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1WXN6@135613|Chromatiales 135613|Chromatiales J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_640181_1 1458357.BG58_40745 9.52e-55 182.0 COG1063@1|root,COG1063@2|Bacteria,1MWX0@1224|Proteobacteria,2VKWS@28216|Betaproteobacteria,1K3IT@119060|Burkholderiaceae 28216|Betaproteobacteria E Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_846288_2 1232437.KL662006_gene4388 4.09e-50 165.0 2C477@1|root,32RDF@2|Bacteria,1RKW1@1224|Proteobacteria,42SWN@68525|delta/epsilon subdivisions,2WP88@28221|Deltaproteobacteria 28221|Deltaproteobacteria S DGC domain - - - - - - - - - - - - DGC k59_376402_1 314278.NB231_00235 4.28e-131 382.0 COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,1SYQK@1236|Gammaproteobacteria,1X0BB@135613|Chromatiales 135613|Chromatiales M NmrA-like family - - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase k59_114281_1 76114.p2A146 1.66e-37 140.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VK6J@28216|Betaproteobacteria,2KX2N@206389|Rhodocyclales 206389|Rhodocyclales L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_584937_1 883080.HMPREF9697_00894 5.18e-100 305.0 COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,2TS24@28211|Alphaproteobacteria,3JQN1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria F Thymidine phosphorylase - - 2.4.2.4 ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C k59_1107669_1 95619.PM1_0208010 3.74e-86 265.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the argininosuccinate synthase family. Type argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_165117_1 935840.JAEQ01000016_gene2184 1.42e-95 295.0 COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria 28211|Alphaproteobacteria EG Belongs to the IlvD Edd family MA20_16960 - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_114282_1 436308.Nmar_1605 1.09e-91 280.0 COG2262@1|root,arCOG00353@2157|Archaea,41SD4@651137|Thaumarchaeota 651137|Thaumarchaeota S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_219446_1 1123368.AUIS01000015_gene2648 5.96e-18 83.2 COG0435@1|root,COG0435@2|Bacteria,1MV50@1224|Proteobacteria,1RMTI@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Glutathione S-Transferase yqjG - 1.8.5.7 ko:K07393 - - - - ko00000,ko01000 - - - GST_C_2,GST_N_2 k59_219446_2 980584.AFPB01000167_gene1982 5.61e-08 53.1 COG1335@1|root,COG1335@2|Bacteria,4NM75@976|Bacteroidetes,1I5WY@117743|Flavobacteriia 976|Bacteroidetes Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_1159113_1 1379270.AUXF01000002_gene1842 5.14e-57 204.0 COG0841@1|root,COG0841@2|Bacteria,1ZT98@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MMPL family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1474978_1 436308.Nmar_0242 3.25e-81 260.0 COG1241@1|root,arCOG00439@2157|Archaea,41SA7@651137|Thaumarchaeota 651137|Thaumarchaeota L Belongs to the MCM family - - - ko:K10726 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - MCM,MCM_N,MCM_OB k59_1214414_2 525368.HMPREF0591_5141 2.32e-31 122.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,235I4@1762|Mycobacteriaceae 201174|Actinobacteria Q cytochrome p450 - - - - - - - - - - - - p450 k59_324570_1 330214.NIDE0600 1.58e-30 119.0 COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,3J0VG@40117|Nitrospirae 40117|Nitrospirae S Belongs to the peptidase M50B family - - - - - - - - - - - - CBS,Peptidase_M50 k59_846310_1 330214.NIDE3941 7.41e-45 166.0 COG2202@1|root,COG3290@1|root,COG4191@1|root,COG5002@1|root,COG2202@2|Bacteria,COG3290@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,3J124@40117|Nitrospirae 40117|Nitrospirae T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_65657_1 1266914.ATUK01000010_gene1520 2.15e-57 186.0 COG0500@1|root,COG2226@2|Bacteria,1QWW2@1224|Proteobacteria,1T361@1236|Gammaproteobacteria,1WY3X@135613|Chromatiales 135613|Chromatiales Q Protein of unknown function (DUF938) - - - - - - - - - - - - DUF938 k59_65657_2 765912.Thimo_3265 3.68e-124 365.0 COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,1SYTB@1236|Gammaproteobacteria,1WWFT@135613|Chromatiales 135613|Chromatiales S PFAM oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA k59_584963_1 1089553.Tph_c21150 9.05e-90 281.0 COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,42F8U@68295|Thermoanaerobacterales 186801|Clostridia J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_584963_2 768671.ThimaDRAFT_4861 5.69e-12 65.9 COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,1RNJD@1236|Gammaproteobacteria,1WX9A@135613|Chromatiales 135613|Chromatiales GM PFAM NAD-dependent epimerase dehydratase - - 4.1.1.35 ko:K08678 ko00520,ko01100,map00520,map01100 M00361 R01384 RC00508 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_1315909_1 234267.Acid_2464 3.78e-14 77.4 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria 57723|Acidobacteria KLTU WD40 domain protein beta Propeller - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase k59_272573_1 977880.pRALTA_0366 3.55e-74 239.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,2VKXT@28216|Betaproteobacteria,1KGPU@119060|Burkholderiaceae 28216|Betaproteobacteria KT PFAM sigma-54 factor interaction domain-containing protein nifA - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_1475912_1 62928.azo0072 1.3e-17 88.2 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VP9Y@28216|Betaproteobacteria,2KVNY@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,sCache_3_3 k59_1369292_1 1227500.C494_14503 0.000398 47.8 COG0596@1|root,arCOG01648@2157|Archaea,2XUZM@28890|Euryarchaeota,23UVW@183963|Halobacteria 183963|Halobacteria S hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_1 k59_899474_1 319003.Bra1253DRAFT_07658 1.5e-30 122.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,3JSY1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1267873_1 485913.Krac_1703 3.37e-56 196.0 COG1060@1|root,COG1060@2|Bacteria,2G7YI@200795|Chloroflexi 200795|Chloroflexi H 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit - - 2.5.1.77 ko:K11779 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_272574_1 1122998.AUHZ01000002_gene2193 3.04e-17 80.9 COG1180@1|root,COG1180@2|Bacteria 2|Bacteria C glycyl-radical enzyme activating activity pflA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_272574_2 411684.HPDFL43_16131 1.05e-99 306.0 COG0025@1|root,COG0025@2|Bacteria,1QTW8@1224|Proteobacteria,2U0BC@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_115013_1 215803.DB30_1343 1.1e-26 110.0 COG2010@1|root,COG3748@1|root,COG2010@2|Bacteria,COG3748@2|Bacteria,1PEGU@1224|Proteobacteria,434ZM@68525|delta/epsilon subdivisions,2X93H@28221|Deltaproteobacteria,2Z1PW@29|Myxococcales 28221|Deltaproteobacteria C Cytochrome c - - - - - - - - - - - - - k59_899477_1 478749.BRYFOR_05545 1.6e-07 58.2 COG0544@1|root,COG0544@2|Bacteria,1V4MT@1239|Firmicutes,24IIC@186801|Clostridia 186801|Clostridia M FKBP-type peptidyl-prolyl cis-trans isomerase - - - - - - - - - - - - FKBP_C,Trigger_C k59_1215255_1 1030157.AFMP01000015_gene3474 9.99e-36 132.0 28KNT@1|root,2ZA6Z@2|Bacteria,1R4VT@1224|Proteobacteria,2U2YA@28211|Alphaproteobacteria,2K4YW@204457|Sphingomonadales 1224|Proteobacteria S EthD domain - - - - - - - - - - - - EthD k59_1316470_1 1049564.TevJSym_bb00050 1.37e-91 288.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_798187_1 426117.M446_2319 8.32e-253 711.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,1JTP3@119045|Methylobacteriaceae 28211|Alphaproteobacteria IQ PFAM AMP-dependent synthetase and ligase acsf - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_798187_2 595537.Varpa_4248 2.04e-07 52.4 COG5569@1|root,COG5569@2|Bacteria,1N8CJ@1224|Proteobacteria,2VVSU@28216|Betaproteobacteria,4AFJQ@80864|Comamonadaceae 28216|Betaproteobacteria S Copper binding periplasmic protein CusF - - - - - - - - - - - - CusF_Ec k59_798187_3 483219.LILAB_03770 3.49e-121 379.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2YUB0@29|Myxococcales 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_429209_1 59538.XP_005964270.1 1.54e-60 194.0 COG3703@1|root,KOG3182@2759|Eukaryota 2759|Eukaryota P Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides - GO:0003674,GO:0003824,GO:0003839,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006751,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0016603,GO:0016740,GO:0016746,GO:0016755,GO:0016829,GO:0016840,GO:0016842,GO:0034641,GO:0042219,GO:0042221,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044248,GO:0044273,GO:0044424,GO:0044464,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0070887,GO:0071704,GO:0097237,GO:0098754,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1990748 - ko:K07232 - - - - ko00000 - - - ChaC k59_1267891_1 404380.Gbem_3035 3.89e-07 54.7 COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,42Q4M@68525|delta/epsilon subdivisions,2WKZN@28221|Deltaproteobacteria,43UM5@69541|Desulfuromonadales 28221|Deltaproteobacteria S Phage late control gene D protein (GPD) tssI - - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - Gp5_C,Phage_GPD k59_585729_1 1313172.YM304_15410 5.19e-70 224.0 COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CMTJ@84992|Acidimicrobiia 84992|Acidimicrobiia I Belongs to the thiolase family - - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_482197_1 1229909.NSED_08970 4.28e-119 353.0 arCOG08812@1|root,arCOG08812@2157|Archaea,41T50@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_429211_1 349124.Hhal_0421 6.86e-16 77.4 COG2251@1|root,COG2251@2|Bacteria,1QUUG@1224|Proteobacteria,1T3FR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function(DUF2779) - - - - - - - - - - - - DUF2779 k59_429211_2 1117958.PE143B_0119250 6.96e-37 131.0 COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,1S7VQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Glutathione S-Transferase yibF - - - - - - - - - - - GST_C_2,GST_N_3 k59_585731_1 861299.J421_2707 2.81e-32 128.0 COG1022@1|root,COG1022@2|Bacteria,1ZT60@142182|Gemmatimonadetes 142182|Gemmatimonadetes I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_950936_1 316067.Geob_3466 1.56e-39 151.0 COG1305@1|root,COG1305@2|Bacteria,1PEH8@1224|Proteobacteria 1224|Proteobacteria E Transglutaminase-like - - - - - - - - - - - - Transglut_core k59_1108431_1 1269813.ATUL01000010_gene471 5.9e-25 99.4 COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,1S6VJ@1236|Gammaproteobacteria,1WYAC@135613|Chromatiales 135613|Chromatiales NU pilus assembly protein PilP - - - ko:K02665 - - - - ko00000,ko02035,ko02044 - - - PilP k59_220197_2 555793.WSK_4158 2.98e-08 59.3 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VGSR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_272604_1 47839.CCAU010000004_gene1016 7.87e-40 145.0 COG1063@1|root,COG1063@2|Bacteria,2IBQC@201174|Actinobacteria,23300@1762|Mycobacteriaceae 201174|Actinobacteria E Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_272604_2 1206735.BAGG01000261_gene6500 7.61e-07 53.9 COG4221@1|root,COG4221@2|Bacteria,2GP17@201174|Actinobacteria,4FXIB@85025|Nocardiaceae 201174|Actinobacteria S KR domain - - - - - - - - - - - - adh_short k59_533366_1 1123253.AUBD01000001_gene1732 1.55e-52 184.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1X2ZU@135614|Xanthomonadales 135614|Xanthomonadales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_1369322_1 330214.NIDE2267 4.17e-13 68.9 COG2204@1|root,COG2204@2|Bacteria,3J0ZU@40117|Nitrospirae 40117|Nitrospirae T Bacterial regulatory protein, Fis family - - - ko:K07715 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_66616_1 1090318.ATTI01000001_gene726 2.22e-58 195.0 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2U9QB@28211|Alphaproteobacteria,2K55Y@204457|Sphingomonadales 204457|Sphingomonadales O Belongs to the glutaredoxin family. Monothiol subfamily grxD - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin k59_1522356_1 247639.MGP2080_12708 4.07e-93 288.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - 1.3.1.34 ko:K00219 - - - - ko00000,ko01000 - - - Oxidored_FMN k59_1475961_1 1125863.JAFN01000001_gene1004 2.13e-89 275.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Aminotransferase class I and II yfdZ - 2.6.1.83 ko:K10206,ko:K14261 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_220207_1 925984.E5AGE6_9CAUD 1.7e-05 49.3 4QAQV@10239|Viruses,4QUPK@35237|dsDNA viruses no RNA stage,4QPCB@28883|Caudovirales,4QIGG@10662|Myoviridae 10662|Myoviridae S Peptidase S24-like - - - - - - - - - - - - - k59_325337_1 254945.Erum5500 1.34e-78 254.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2TR5H@28211|Alphaproteobacteria,47EZM@766|Rickettsiales 766|Rickettsiales O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_742324_1 237368.SCABRO_02642 7.74e-34 120.0 COG0390@1|root,COG0390@2|Bacteria,2J0PF@203682|Planctomycetes 203682|Planctomycetes S Uncharacterised protein family (UPF0014) - - - ko:K02069 - M00211 - - ko00000,ko00002,ko02000 9.B.25.1 - - UPF0014 k59_692152_1 1123320.KB889687_gene937 1.39e-40 151.0 COG0318@1|root,COG0318@2|Bacteria,2GMVB@201174|Actinobacteria 201174|Actinobacteria IQ Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_641207_1 1380600.AUYN01000009_gene1319 0.000553 45.8 2DM2K@1|root,31G7J@2|Bacteria,4NQIU@976|Bacteroidetes,1I2UQ@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4136) - - - - - - - - - - - - DUF4136 k59_950961_1 644282.Deba_3041 7.83e-116 348.0 COG0076@1|root,COG0076@2|Bacteria,1MX25@1224|Proteobacteria,42NCK@68525|delta/epsilon subdivisions,2WMCF@28221|Deltaproteobacteria 28221|Deltaproteobacteria E COG0076 Glutamate decarboxylase and related PLP-dependent - - 4.1.2.27 ko:K01634 ko00600,ko01100,ko04071,map00600,map01100,map04071 M00100 R02464,R06516 RC00264,RC00721,RC01266 ko00000,ko00001,ko00002,ko01000 - - - Pyridoxal_deC k59_1422394_1 391593.RCCS2_14589 9.52e-24 103.0 COG0697@1|root,COG0697@2|Bacteria,1MX07@1224|Proteobacteria,2TQNT@28211|Alphaproteobacteria,2P26Q@2433|Roseobacter 28211|Alphaproteobacteria EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_165872_1 591158.SSMG_04085 2.88e-24 97.1 2DM54@1|root,31RK3@2|Bacteria,2I4CJ@201174|Actinobacteria 201174|Actinobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_226788_1 396588.Tgr7_2755 8.42e-178 508.0 COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1WXB2@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPB - 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - Aminotran_5,GDC-P k59_1584635_1 1121439.dsat_1302 1.22e-21 96.7 COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,42R3N@68525|delta/epsilon subdivisions,2WMY8@28221|Deltaproteobacteria,2MAPG@213115|Desulfovibrionales 28221|Deltaproteobacteria C TIGRFAM eight transmembrane protein EpsH epsH - - - - - - - - - - - Exosortase_EpsH k59_436364_1 27337.EGY17037 6.82e-08 59.3 COG0438@1|root,KOG1111@2759|Eukaryota,39U75@33154|Opisthokonta,3P16Y@4751|Fungi,3QR19@4890|Ascomycota,216DS@147550|Sordariomycetes,1EU6D@1028384|Glomerellales 4751|Fungi IMO Glycosyl transferase - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_1276923_1 754477.Q7C_2468 8.68e-85 269.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,45ZXC@72273|Thiotrichales 72273|Thiotrichales C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_1165079_1 671143.DAMO_0980 1.67e-24 108.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2NP1J@2323|unclassified Bacteria 2|Bacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1115072_1 697281.Mahau_0265 1.2e-39 146.0 COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,248X8@186801|Clostridia,42EK0@68295|Thermoanaerobacterales 186801|Clostridia E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23,1.1.1.308 ko:K00013,ko:K15509 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_1115072_2 1123487.KB892865_gene1480 4.47e-18 82.4 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2VIF9@28216|Betaproteobacteria,2KUBS@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG k59_123523_1 1121459.AQXE01000001_gene2751 1.3e-53 179.0 28IR7@1|root,2Z8QR@2|Bacteria,1PBTP@1224|Proteobacteria,42Z7V@68525|delta/epsilon subdivisions,2WTZ3@28221|Deltaproteobacteria,2M8NA@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_906263_1 545276.KB898724_gene1892 2.84e-122 375.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales 135613|Chromatiales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1375847_1 545276.KB898727_gene506 8.89e-29 120.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1WW3A@135613|Chromatiales 135613|Chromatiales F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_1584664_2 7955.ENSDARP00000058889 1.44e-07 53.9 COG0596@1|root,COG1011@1|root,KOG3085@2759|Eukaryota,KOG4178@2759|Eukaryota,39WAD@33154|Opisthokonta,3BACN@33208|Metazoa,3CVBC@33213|Bilateria,482KF@7711|Chordata,48X7C@7742|Vertebrata,49THC@7898|Actinopterygii 33208|Metazoa I Epoxide hydrolase 2 EPHX2 GO:0000287,GO:0001676,GO:0002532,GO:0002538,GO:0002539,GO:0003008,GO:0003013,GO:0003018,GO:0003674,GO:0003824,GO:0004301,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006605,GO:0006625,GO:0006629,GO:0006631,GO:0006633,GO:0006690,GO:0006725,GO:0006793,GO:0006796,GO:0006805,GO:0006810,GO:0006873,GO:0006874,GO:0006875,GO:0006886,GO:0006950,GO:0006952,GO:0006954,GO:0006996,GO:0007031,GO:0007600,GO:0008015,GO:0008104,GO:0008150,GO:0008152,GO:0008217,GO:0008610,GO:0009056,GO:0009058,GO:0009410,GO:0009636,GO:0009810,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0015031,GO:0015643,GO:0015833,GO:0016043,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016801,GO:0016803,GO:0017144,GO:0018904,GO:0019216,GO:0019218,GO:0019222,GO:0019233,GO:0019369,GO:0019373,GO:0019439,GO:0019725,GO:0019752,GO:0030003,GO:0030258,GO:0031907,GO:0031974,GO:0032501,GO:0032787,GO:0033036,GO:0033365,GO:0033559,GO:0034613,GO:0035150,GO:0035296,GO:0042221,GO:0042577,GO:0042578,GO:0042579,GO:0042592,GO:0042632,GO:0042759,GO:0042802,GO:0042803,GO:0042886,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043651,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0045777,GO:0046272,GO:0046394,GO:0046483,GO:0046839,GO:0046872,GO:0046907,GO:0046983,GO:0048518,GO:0048878,GO:0050789,GO:0050801,GO:0050877,GO:0050880,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055088,GO:0055092,GO:0060255,GO:0062012,GO:0065007,GO:0065008,GO:0070013,GO:0070727,GO:0070887,GO:0071466,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072330,GO:0072503,GO:0072507,GO:0072593,GO:0072594,GO:0072662,GO:0072663,GO:0080090,GO:0090066,GO:0090181,GO:0097176,GO:0097746,GO:0097755,GO:0098771,GO:1900673,GO:1901360,GO:1901361,GO:1901568,GO:1901575,GO:1901576 3.1.3.76,3.3.2.10 ko:K08726,ko:K10089 ko00590,ko00625,ko01100,ko01120,ko04142,ko04145,ko04146,map00590,map00625,map01100,map01120,map04142,map04145,map04146 - R05842,R07108,R07109,R07110,R07111 RC01477,RC01757 ko00000,ko00001,ko01000,ko01002,ko01009,ko04091,ko04147 - - - Abhydrolase_1,HAD_2 k59_123540_1 84531.JMTZ01000101_gene1444 6.27e-12 73.2 COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,1RNZM@1236|Gammaproteobacteria,1X4Z4@135614|Xanthomonadales 135614|Xanthomonadales M protein involved in outer membrane biogenesis asmA - - ko:K07290 - - - - ko00000 9.B.121 - - AsmA k59_957507_1 314278.NB231_16558 6.85e-101 313.0 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria,1X0J6@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - HlyD_D23,HlyD_D4,YtkA k59_957507_2 1033802.SSPSH_001035 3.38e-26 107.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_172162_1 500637.PROVRUST_05543 1.81e-22 96.7 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,3Z8FV@586|Providencia 1236|Gammaproteobacteria L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase rarA GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_172162_2 46429.BV95_01523 4.83e-11 67.4 COG0790@1|root,COG3147@1|root,COG0790@2|Bacteria,COG3147@2|Bacteria,1RJ71@1224|Proteobacteria,2U15P@28211|Alphaproteobacteria,2K032@204457|Sphingomonadales 204457|Sphingomonadales S FOG TPR repeat, SEL1 subfamily - - - ko:K07126 - - - - ko00000 - - - SPOR,Sel1 k59_807106_1 1229909.NSED_01430 7.27e-117 349.0 COG0260@1|root,arCOG04322@2157|Archaea,41SYD@651137|Thaumarchaeota 651137|Thaumarchaeota E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_124440_1 443143.GM18_0460 2.63e-126 372.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42MI0@68525|delta/epsilon subdivisions,2WIW4@28221|Deltaproteobacteria 28221|Deltaproteobacteria C TIGRFAM hydrogenase (NiFe) small subunit (hydA) hyaS - 1.12.2.1,1.12.99.6 ko:K06282,ko:K18008 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - iAF987.Gmet_3332 NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal k59_124440_2 357808.RoseRS_2320 7.85e-71 229.0 COG0374@1|root,COG0374@2|Bacteria,2G6SF@200795|Chloroflexi,376Y8@32061|Chloroflexia 32061|Chloroflexia C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_1431944_1 760568.Desku_2520 2.36e-138 417.0 COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,260N4@186807|Peptococcaceae 186801|Clostridia C formate C-acetyltransferase glycine radical - - 2.3.1.54,4.3.99.4 ko:K00656,ko:K20038 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like k59_1431944_2 1121434.AULY01000009_gene2032 1.84e-14 71.2 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,43B8B@68525|delta/epsilon subdivisions,2X6MP@28221|Deltaproteobacteria,2MH4M@213115|Desulfovibrionales 28221|Deltaproteobacteria C glycyl-radical enzyme activating protein family - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4,Fer4_12,Radical_SAM k59_280269_1 649638.Trad_0654 1.82e-81 254.0 COG0183@1|root,COG0183@2|Bacteria,1WIPU@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I Belongs to the thiolase family - - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1638556_1 321846.PS417_24690 3.36e-66 211.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_1427,iB21_1397.B21_00586,iBWG_1329.BWG_0499,iE2348C_1286.E2348C_0528,iEC55989_1330.EC55989_0620,iECABU_c1320.ECABU_c06820,iECBD_1354.ECBD_3023,iECB_1328.ECB_00597,iECDH10B_1368.ECDH10B_0589,iECDH1ME8569_1439.ECDH1ME8569_0597,iECD_1391.ECD_00597,iECED1_1282.ECED1_0624,iECH74115_1262.ECH74115_0716,iECIAI1_1343.ECIAI1_0611,iECIAI39_1322.ECIAI39_0603,iECNA114_1301.ECNA114_0567,iECO103_1326.ECO103_0635,iECO111_1330.ECO111_0658,iECO26_1355.ECO26_0702,iECOK1_1307.ECOK1_0638,iECP_1309.ECP_0658,iECS88_1305.ECS88_0669,iECSE_1348.ECSE_0695,iECSF_1327.ECSF_0567,iECSP_1301.ECSP_0681,iECUMN_1333.ECUMN_0720,iECW_1372.ECW_m0682,iECs_1301.ECs0666,iEKO11_1354.EKO11_3238,iETEC_1333.ETEC_0656,iEcDH1_1363.EcDH1_2998,iEcE24377_1341.EcE24377A_0652,iEcHS_1320.EcHS_A0679,iEcSMS35_1347.EcSMS35_0648,iEcolC_1368.EcolC_3017,iG2583_1286.G2583_0791,iJO1366.b0628,iLF82_1304.LF82_1199,iNRG857_1313.NRG857_02855,iSBO_1134.SBO_0492,iSDY_1059.SDY_0550,iSF_1195.SF0653,iSFxv_1172.SFxv_0720,iSSON_1240.SSON_0582,iS_1188.S0675,iSbBS512_1146.SbBS512_E0542,iUMN146_1321.UM146_14375,iUMNK88_1353.UMNK88_663,iUTI89_1310.UTI89_C0631,iWFL_1372.ECW_m0682,iY75_1357.Y75_RS03275,ic_1306.c0718 LIAS_N,Radical_SAM k59_492003_1 795666.MW7_1112 1.42e-05 52.4 COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,2VH69@28216|Betaproteobacteria,1K2B6@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose hldD - 5.1.3.20 ko:K03274 ko00540,ko01100,map00540,map01100 M00064 R05176 RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase k59_699622_2 445335.CBN_0041 1.13e-09 60.1 2ED6K@1|root,3373A@2|Bacteria,1VI2S@1239|Firmicutes,24QZV@186801|Clostridia,36TJ8@31979|Clostridiaceae 186801|Clostridia S the current gene model (or a revised gene model) may contain one or more premature stops and or frameshifts - - - - - - - - - - - - - k59_1165609_1 1343740.M271_15840 1.69e-62 202.0 COG2141@1|root,COG2141@2|Bacteria,2GMUP@201174|Actinobacteria 201174|Actinobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_1431965_1 1229909.NSED_09005 1.05e-39 144.0 COG1155@1|root,arCOG00868@2157|Archaea,41SZU@651137|Thaumarchaeota 651137|Thaumarchaeota F Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit atpA - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_1431965_2 1229909.NSED_09010 2.14e-89 268.0 COG1390@1|root,arCOG00869@2157|Archaea,41T4W@651137|Thaumarchaeota 651137|Thaumarchaeota C Produces ATP from ADP in the presence of a proton gradient across the membrane atpE - - ko:K02121 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_E k59_227530_1 1408424.JHYI01000002_gene4103 1.51e-09 60.5 COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,4HEZ4@91061|Bacilli,1ZD9Y@1386|Bacillus 91061|Bacilli E Aminotransferase class-III - - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1223355_1 794846.AJQU01000022_gene1457 6.55e-73 233.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2U2JT@28211|Alphaproteobacteria,4BB5D@82115|Rhizobiaceae 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF2 - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_1485624_1 1123320.KB889585_gene1891 9.8e-71 226.0 COG1960@1|root,COG1960@2|Bacteria,2I8MN@201174|Actinobacteria 201174|Actinobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_749728_1 266117.Rxyl_0432 2.06e-42 142.0 COG1504@1|root,COG1504@2|Bacteria,2IRTB@201174|Actinobacteria 201174|Actinobacteria S Protein of unknown function (DUF498/DUF598) - - - - - - - - - - - - DUF498 k59_749728_2 485917.Phep_3084 1.55e-48 165.0 COG0614@1|root,COG0614@2|Bacteria,4NI2Y@976|Bacteroidetes,1IRZV@117747|Sphingobacteriia 976|Bacteroidetes P PFAM periplasmic binding protein fecB - - - - - - - - - - - Peripla_BP_2 k59_386810_2 1266925.JHVX01000002_gene1097 7.5e-27 110.0 COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,2VNEJ@28216|Betaproteobacteria,372ID@32003|Nitrosomonadales 28216|Betaproteobacteria S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139 k59_76307_1 1232410.KI421425_gene1543 4.26e-21 96.7 COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,42XJ0@68525|delta/epsilon subdivisions,2WT3A@28221|Deltaproteobacteria,43SUP@69541|Desulfuromonadales 28221|Deltaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - - - - - - - - - - TonB_C k59_124488_2 1217718.ALOU01000007_gene1259 1.04e-63 207.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2VM5U@28216|Betaproteobacteria,1KF02@119060|Burkholderiaceae 28216|Betaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_8417_1 330214.NIDE0386 8.28e-76 239.0 COG2377@1|root,COG2377@2|Bacteria,3J126@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_1585441_1 749414.SBI_01183 8.89e-18 84.7 COG2801@1|root,COG2801@2|Bacteria,2GN25@201174|Actinobacteria 201174|Actinobacteria L Integrase catalytic - - - - - - - - - - - - rve_3 k59_332774_2 216432.CA2559_01900 2.42e-38 149.0 COG0514@1|root,COG0514@2|Bacteria,4NG10@976|Bacteroidetes,1HXWC@117743|Flavobacteriia 976|Bacteroidetes L ATP-dependent DNA helicase RecQ recQ3 - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind k59_854622_1 335543.Sfum_0853 4.29e-58 196.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MR37@213462|Syntrophobacterales 28221|Deltaproteobacteria K two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_808085_2 1269813.ATUL01000003_gene2388 5.81e-14 78.2 COG0642@1|root,COG0745@1|root,COG2202@1|root,COG4191@1|root,COG5002@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,1T1YU@1236|Gammaproteobacteria,1WXQM@135613|Chromatiales 135613|Chromatiales T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg k59_124494_2 595460.RRSWK_04882 3.57e-54 181.0 COG0631@1|root,COG0631@2|Bacteria 2|Bacteria T protein serine/threonine phosphatase activity - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_808088_1 1156937.MFUM_990011 4.79e-35 133.0 COG0787@1|root,COG0787@2|Bacteria,46SM1@74201|Verrucomicrobia,37GBR@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_1010879_1 1282876.BAOK01000001_gene3335 1.61e-85 263.0 COG0398@1|root,COG0398@2|Bacteria,1RBAE@1224|Proteobacteria,2U6B6@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function, DUF547 - - - - - - - - - - - - DUF547 k59_1010879_2 1177928.TH2_19939 1.4e-27 104.0 COG3462@1|root,COG3462@2|Bacteria,1NGXC@1224|Proteobacteria,2UKQ8@28211|Alphaproteobacteria,2JUIX@204441|Rhodospirillales 204441|Rhodospirillales S Short C-terminal domain - - - - - - - - - - - - SHOCT k59_332782_1 545264.KB898750_gene261 9.73e-66 224.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,LysM k59_958219_1 756272.Plabr_2779 1.74e-20 94.0 COG0287@1|root,COG0287@2|Bacteria,2IZ5K@203682|Planctomycetes 203682|Planctomycetes E Prephenate dehydrogenase - - 1.3.1.12,1.3.1.43 ko:K00210,ko:K00220,ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025,M00040 R00732,R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_958219_2 502025.Hoch_2382 1.6e-110 338.0 COG0539@1|root,COG2183@1|root,COG0539@2|Bacteria,COG2183@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2YU9B@29|Myxococcales 28221|Deltaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_124511_2 861299.J421_3379 3.31e-20 85.1 COG3809@1|root,COG3809@2|Bacteria 2|Bacteria S Transcription factor zinc-finger - - - ko:K09981 - - - - ko00000 - - - Rhomboid,zf-TFIIB k59_124511_3 1131813.AQVT01000001_gene927 1.4e-06 50.4 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,2TRGM@28211|Alphaproteobacteria,1JRWK@119045|Methylobacteriaceae 28211|Alphaproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_227576_1 530564.Psta_4193 1.82e-115 358.0 COG0433@1|root,COG0433@2|Bacteria,2IY71@203682|Planctomycetes 203682|Planctomycetes L AAA-like domain - - - - - - - - - - - - DUF853,DUF87,PDDEXK_1 k59_227576_2 471852.Tcur_3965 4.98e-19 85.5 COG1309@1|root,COG1309@2|Bacteria,2GTRY@201174|Actinobacteria 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1322011_1 1279017.AQYJ01000019_gene1446 3.2e-26 103.0 COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,1SAQE@1236|Gammaproteobacteria,4699N@72275|Alteromonadaceae 1236|Gammaproteobacteria S YbaK prolyl-tRNA synthetase associated - - - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_280329_1 1177154.Y5S_00553 1.29e-109 330.0 COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,1SKHE@1236|Gammaproteobacteria 1236|Gammaproteobacteria V ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane_3 k59_280329_3 349521.HCH_01777 3.11e-67 215.0 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1XJNT@135619|Oceanospirillales 135619|Oceanospirillales O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_1638644_1 1485544.JQKP01000001_gene1257 1.66e-46 159.0 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2VINM@28216|Betaproteobacteria,44VH9@713636|Nitrosomonadales 28216|Betaproteobacteria M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_1277984_2 83219.PM02_12445 6.78e-63 210.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2TSSI@28211|Alphaproteobacteria,3ZYCR@60136|Sulfitobacter 28211|Alphaproteobacteria I AMP-binding enzyme MA20_19425 - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_1322015_1 246197.MXAN_7028 1.43e-74 240.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2WIK7@28221|Deltaproteobacteria,2YUF7@29|Myxococcales 28221|Deltaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1638653_1 268746.Q58MP3_BPPRM 1.77e-71 244.0 4QBUC@10239|Viruses,4QQGQ@28883|Caudovirales,4QHY3@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1063973_1 436308.Nmar_0689 6.69e-51 164.0 arCOG08023@1|root,arCOG08023@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - zinc_ribbon_2 k59_1063973_2 436308.Nmar_1423 1.23e-50 164.0 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_907059_1 583355.Caka_2184 5.3e-35 127.0 COG1136@1|root,COG1136@2|Bacteria 2|Bacteria V lipoprotein transporter activity - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_593225_1 706434.HMPREF9429_00631 3.56e-07 59.3 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,4H2CW@909932|Negativicutes 909932|Negativicutes L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_958244_1 395493.BegalDRAFT_2316 5.04e-110 325.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,4602A@72273|Thiotrichales 72273|Thiotrichales L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_958244_2 1121405.dsmv_3198 1.25e-37 129.0 COG3189@1|root,COG3189@2|Bacteria,1RHYB@1224|Proteobacteria,42SR4@68525|delta/epsilon subdivisions,2WPV2@28221|Deltaproteobacteria,2MNNT@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function, DUF488 - - - - - - - - - - - - DUF488 k59_1376580_1 243090.RB3014 1.56e-32 129.0 COG1404@1|root,COG1404@2|Bacteria,2IZNN@203682|Planctomycetes 203682|Planctomycetes O alpha-L-arabinofuranosidase - - - - - - - - - - - - SBBP k59_332815_1 1288494.EBAPG3_19110 2.89e-15 78.2 2EBZ0@1|root,335Y9@2|Bacteria,1NF45@1224|Proteobacteria,2WBD3@28216|Betaproteobacteria,372VS@32003|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_332815_2 444878.E3SRB4_9CAUD 5.37e-17 73.6 4QHHP@10239|Viruses,4QWAC@35237|dsDNA viruses no RNA stage,4QS3Z@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1063984_1 436308.Nmar_0567 3.06e-31 118.0 arCOG11722@1|root,arCOG11722@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1585491_1 426114.THI_3689 1.78e-26 109.0 COG2251@1|root,COG2251@2|Bacteria,1QUUG@1224|Proteobacteria,2W0DD@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function(DUF2779) - - - - - - - - - - - - DUF2779 k59_88588_1 745411.B3C1_14223 2.62e-29 113.0 COG0515@1|root,COG0515@2|Bacteria,1QUW7@1224|Proteobacteria,1T23C@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position kdkA - 2.7.1.166 ko:K11211 ko00540,map00540 - R09767 RC00002,RC00078 ko00000,ko00001,ko01000 - - - Kdo k59_88588_2 187272.Mlg_2637 3.23e-44 159.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1WX73@135613|Chromatiales 135613|Chromatiales M PFAM Three-deoxy-D-manno-octulosonic-acid transferase - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N,Kdo k59_1234452_1 926560.KE387025_gene3944 5.43e-231 660.0 COG1449@1|root,COG1501@1|root,COG1449@2|Bacteria,COG1501@2|Bacteria,1WJCV@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Glycosyl hydrolase family 57 - - - - - - - - - - - - Glucodextran_C,Glyco_hydro_57 k59_1498212_2 436308.Nmar_1430 1.46e-25 100.0 COG1383@1|root,arCOG01885@2157|Archaea,41SUH@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein - - - ko:K02962 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17e k59_1385011_1 1123401.JHYQ01000002_gene2583 2.46e-69 223.0 COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,1S03J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Major facilitator superfamily - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_236591_2 330214.NIDE2788 1.32e-19 83.2 2EBKA@1|root,335KQ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_758779_1 207954.MED92_17480 8.96e-23 103.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1XIQW@135619|Oceanospirillales 135619|Oceanospirillales M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) mrcB - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_758779_2 411464.DESPIG_00287 1.54e-34 130.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,42M7Y@68525|delta/epsilon subdivisions,2WIRN@28221|Deltaproteobacteria,2M7RT@213115|Desulfovibrionales 28221|Deltaproteobacteria E TIGRFAM argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1,NUDIX k59_663721_1 266264.Rmet_0355 2.66e-14 76.3 COG1877@1|root,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2VRQ8@28216|Betaproteobacteria,1K3QP@119060|Burkholderiaceae 28216|Betaproteobacteria G Removes the phosphate from trehalose 6-phosphate to produce free trehalose otsB - 3.1.3.12 ko:K01087 ko00500,ko01100,map00500,map01100 - R02778 RC00017 ko00000,ko00001,ko01000 - - - Trehalose_PPase k59_88610_2 392499.Swit_1969 5.75e-14 74.3 COG2159@1|root,COG2159@2|Bacteria,1N5TN@1224|Proteobacteria,2UE32@28211|Alphaproteobacteria,2K8VW@204457|Sphingomonadales 204457|Sphingomonadales S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_549566_1 395493.BegalDRAFT_2073 1.32e-59 208.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,4602D@72273|Thiotrichales 72273|Thiotrichales L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1651457_1 436308.Nmar_0795 1.33e-56 177.0 COG0096@1|root,arCOG04091@2157|Archaea,41SMM@651137|Thaumarchaeota 651137|Thaumarchaeota J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rps8 - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_1651457_2 436308.Nmar_0794 2.67e-104 304.0 COG0097@1|root,arCOG04090@2157|Archaea,41SJG@651137|Thaumarchaeota 651137|Thaumarchaeota J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rpl6 - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_1173318_2 425104.Ssed_3141 7.04e-07 53.1 COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,2QAQ7@267890|Shewanellaceae 1236|Gammaproteobacteria S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_663754_1 272568.GDI3670 2.78e-63 221.0 COG0234@1|root,COG0234@2|Bacteria,1NJKP@1224|Proteobacteria,2UM25@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - - k59_290212_1 880072.Desac_1760 3.01e-96 288.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,42SWD@68525|delta/epsilon subdivisions,2WK1W@28221|Deltaproteobacteria,2MQCQ@213462|Syntrophobacterales 28221|Deltaproteobacteria K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_1173321_1 29581.BW37_03173 1.72e-39 147.0 COG2199@1|root,COG3159@1|root,COG3159@2|Bacteria,COG3706@2|Bacteria,1R8F2@1224|Proteobacteria,2VJGD@28216|Betaproteobacteria,472P5@75682|Oxalobacteraceae 28216|Betaproteobacteria T Protein of unknown function, DUF484 - - - - - - - - - - - - DUF484,GGDEF k59_1594528_2 105559.Nwat_2753 1.97e-20 94.0 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria,1WX4U@135613|Chromatiales 135613|Chromatiales T PFAM Metal-dependent phosphohydrolase, HD - - - - - - - - - - - - DUF3391,HD_5 k59_1290758_1 272123.Anacy_5395 0.000708 47.4 COG2931@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria,1GQWP@1117|Cyanobacteria,1HTSF@1161|Nostocales 1117|Cyanobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - - k59_1073687_2 402881.Plav_1858 5.34e-59 201.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,1JPG1@119043|Rhodobiaceae 28211|Alphaproteobacteria E GMC oxidoreductase - - - - - - - - - - - - DAO,FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_135316_1 485918.Cpin_4434 5.59e-23 99.8 COG1801@1|root,COG1801@2|Bacteria,4NI47@976|Bacteroidetes,1IPS2@117747|Sphingobacteriia 976|Bacteroidetes S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 k59_504829_1 1123371.ATXH01000018_gene1411 2.72e-27 106.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_236635_1 1051006.HMPREF1162_1600 1.76e-14 78.2 COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,4DNY6@85009|Propionibacteriales 201174|Actinobacteria KLT serine threonine protein kinase pknB GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_602343_1 1229203.KI301992_gene781 4.76e-48 172.0 COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,3UWBR@52018|unclassified Actinobacteria (class) 201174|Actinobacteria C COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_13388_1 990285.RGCCGE502_20485 3.18e-17 83.2 COG2067@1|root,COG2067@2|Bacteria,1RF1Y@1224|Proteobacteria,2VGDQ@28211|Alphaproteobacteria,4BN0F@82115|Rhizobiaceae 28211|Alphaproteobacteria I long-chain fatty acid transport protein - - - - - - - - - - - - - k59_504839_1 1042377.AFPJ01000036_gene1233 5.84e-103 314.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_1651502_2 306263.Cla_0582 9.11e-10 60.5 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2YM8V@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_1443603_1 436308.Nmar_1729 5.58e-100 299.0 COG0371@1|root,arCOG00982@2157|Archaea,41T0B@651137|Thaumarchaeota 651137|Thaumarchaeota C Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea egsA - 1.1.1.261 ko:K00096 ko00564,map00564 - R05679,R05680 RC00029 ko00000,ko00001,ko01000 - - - Fe-ADH_2 k59_917069_1 330214.NIDE2792 4.32e-35 131.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - NHL k59_1234538_1 1229909.NSED_09625 6.2e-59 189.0 arCOG08041@1|root,arCOG08041@2157|Archaea,41SRT@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - HTH_27 k59_967436_1 379066.GAU_3104 4.88e-44 171.0 COG1196@1|root,COG1196@2|Bacteria,1ZU8V@142182|Gemmatimonadetes 142182|Gemmatimonadetes D nuclear chromosome segregation - - - - - - - - - - - - - k59_1498323_1 1116472.MGMO_11c00630 2.72e-33 125.0 COG3219@1|root,COG3219@2|Bacteria,1R8C9@1224|Proteobacteria,1S23S@1236|Gammaproteobacteria,1XEQC@135618|Methylococcales 135618|Methylococcales S Putative DNA-binding domain - - - ko:K09929 - - - - ko00000 - - - DUF2063 k59_1443617_2 666684.AfiDRAFT_2827 7.32e-34 122.0 2CUA5@1|root,32SUX@2|Bacteria,1RJP0@1224|Proteobacteria,2U9T0@28211|Alphaproteobacteria,3K0GI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Complex I intermediate-associated protein 30 (CIA30) - - - - - - - - - - - - CIA30 k59_448203_1 1125712.HMPREF1316_0805 2.91e-05 51.2 COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,4CUNC@84998|Coriobacteriia 84998|Coriobacteriia L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N k59_448203_2 351160.RCIX685 9.98e-26 110.0 COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,2N91U@224756|Methanomicrobia 224756|Methanomicrobia O Cell division protein 48 (CDC48), domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_290283_1 1122176.KB903544_gene776 1.28e-82 262.0 COG1115@1|root,COG1115@2|Bacteria,4NDX7@976|Bacteroidetes,1IS9Z@117747|Sphingobacteriia 976|Bacteroidetes E Sodium:alanine symporter family - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_1173368_2 1163407.UU7_00110 8.89e-43 154.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1X2YR@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_602377_1 1248916.ANFY01000004_gene1674 1.8e-50 170.0 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2TS7C@28211|Alphaproteobacteria,2K19F@204457|Sphingomonadales 204457|Sphingomonadales H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_1498332_1 479432.Sros_8851 6.04e-51 174.0 2DBC8@1|root,2Z8C9@2|Bacteria,2I93W@201174|Actinobacteria,4EMD4@85012|Streptosporangiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_663835_1 243233.MCA1077 2.75e-60 194.0 COG2022@1|root,COG2104@1|root,COG2022@2|Bacteria,COG2104@2|Bacteria,1N0N5@1224|Proteobacteria,1RMPD@1236|Gammaproteobacteria,1XDXA@135618|Methylococcales 135618|Methylococcales H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG,ThiS k59_663835_2 207954.MED92_06593 6.57e-21 89.4 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,1XH39@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_820898_1 1415780.JPOG01000001_gene1880 4.79e-34 130.0 COG4638@1|root,COG4638@2|Bacteria,1N3CA@1224|Proteobacteria,1S0V7@1236|Gammaproteobacteria,1X4YE@135614|Xanthomonadales 135614|Xanthomonadales P Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_708756_1 583355.Caka_0914 4.7e-20 92.0 COG2003@1|root,COG2003@2|Bacteria,46V3U@74201|Verrucomicrobia,3K80P@414999|Opitutae 414999|Opitutae L DNA repair protein - - - ko:K03630 - - - - ko00000 - - - RadC k59_1073749_1 688270.Celal_2384 0.000373 48.9 COG2931@1|root,COG3210@1|root,COG3420@1|root,COG4935@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3420@2|Bacteria,COG4935@2|Bacteria,4PNSZ@976|Bacteroidetes,1IKBE@117743|Flavobacteriia,1F8UJ@104264|Cellulophaga 976|Bacteroidetes PQU SdrD B-like domain - - - - - - - - - - - - Beta_helix,CUB,Calx-beta,SdrD_B k59_1329711_1 883078.HMPREF9695_00487 2.37e-08 56.6 COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1MVH7@1224|Proteobacteria,2TRNA@28211|Alphaproteobacteria,3JW7V@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria KL DNA methylase - - - - - - - - - - - - N6_N4_Mtase,ParBc k59_1329711_2 314285.KT71_18791 9.59e-35 124.0 2E8HV@1|root,332VX@2|Bacteria,1NB2K@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_917111_1 760568.Desku_2703 6.75e-10 62.4 COG4960@1|root,COG4960@2|Bacteria,1UPNE@1239|Firmicutes,24T5Y@186801|Clostridia 186801|Clostridia OU PFAM peptidase A24A, prepilin type IV - - 3.4.23.43 ko:K02278 - - - - ko00000,ko01000,ko02035,ko02044 - - - Peptidase_A24 k59_663840_1 1449126.JQKL01000068_gene2107 3.71e-10 63.5 COG0671@1|root,COG1238@1|root,COG0671@2|Bacteria,COG1238@2|Bacteria,1VF2U@1239|Firmicutes,24D98@186801|Clostridia,26C27@186813|unclassified Clostridiales 186801|Clostridia I Acid phosphatase homologues - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2,SNARE_assoc k59_1290838_1 179408.Osc7112_3198 2.49e-12 72.8 COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1G13T@1117|Cyanobacteria,1H77Q@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - DUF3365,HAMP,HATPase_c,HisKA,Response_reg k59_549648_1 515635.Dtur_1091 5.77e-57 192.0 COG4656@1|root,COG4656@2|Bacteria 2|Bacteria C electron transfer activity rnfC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_17,Fer4_7,RnfC_N,SLBB k59_820924_1 384765.SIAM614_26548 2.3e-66 226.0 COG1038@1|root,COG1038@2|Bacteria,1NW9R@1224|Proteobacteria,2TQXU@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second pyc - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA k59_1651579_1 1415778.JQMM01000001_gene1226 6.27e-37 144.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1J4N1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG3419 Tfp pilus assembly protein, tip-associated adhesin PilY1 comC - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_1290858_1 498211.CJA_0975 8.32e-13 73.6 COG1657@1|root,COG2304@1|root,COG1657@2|Bacteria,COG2304@2|Bacteria,1RFDH@1224|Proteobacteria,1S0SI@1236|Gammaproteobacteria,1FHU5@10|Cellvibrio 1236|Gammaproteobacteria I CarboxypepD_reg-like domain - - - - - - - - - - - - CarboxypepD_reg,DUF1194,Prenyltrans k59_290323_1 436308.Nmar_1769 2.97e-51 174.0 COG0531@1|root,arCOG00009@2157|Archaea,41SXX@651137|Thaumarchaeota 651137|Thaumarchaeota E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_290323_2 1229909.NSED_02900 3.21e-70 214.0 COG0432@1|root,arCOG04214@2157|Archaea 2157|Archaea S PFAM Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_663872_1 1304872.JAGC01000003_gene3036 2.02e-07 59.3 COG2755@1|root,COG2755@2|Bacteria,1NHW6@1224|Proteobacteria,42XAM@68525|delta/epsilon subdivisions,2WSXZ@28221|Deltaproteobacteria,2MDU0@213115|Desulfovibrionales 28221|Deltaproteobacteria E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 k59_1290862_2 1232437.KL662061_gene4209 6.21e-35 135.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,42MGQ@68525|delta/epsilon subdivisions,2WJ87@28221|Deltaproteobacteria,2MM7A@213118|Desulfobacterales 28221|Deltaproteobacteria E Amino acid permease - - - ko:K03294,ko:K20265 ko02024,map02024 - - - ko00000,ko00001,ko02000 2.A.3.2,2.A.3.7.1,2.A.3.7.3 - - AA_permease_2 k59_602405_1 1232410.KI421418_gene2189 2.57e-106 334.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,43S61@69541|Desulfuromonadales 28221|Deltaproteobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_917156_1 395493.BegalDRAFT_1703 9.96e-114 335.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,461S0@72273|Thiotrichales 72273|Thiotrichales V ABC transporter, ATP-binding protein - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_342545_1 697282.Mettu_2014 2.16e-68 214.0 COG4229@1|root,COG4229@2|Bacteria,1R3V9@1224|Proteobacteria,1RP5Y@1236|Gammaproteobacteria,1XE85@135618|Methylococcales 135618|Methylococcales C Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene) mtnC - 3.1.3.77 ko:K09880 ko00270,ko01100,map00270,map01100 M00034 R07395 RC02779 ko00000,ko00001,ko00002,ko01000 - - - - k59_1385137_1 1229909.NSED_09425 8.14e-86 261.0 COG3794@1|root,arCOG08795@1|root,arCOG02926@2157|Archaea,arCOG08795@2157|Archaea 2157|Archaea C copper ion binding - - - - - - - - - - - - Copper-bind,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1 k59_1073805_1 1112217.PPL19_01120 5.19e-59 200.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Gamma-glutamyltransferase ggt_1 - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1443669_1 1196031.ALEG01000039_gene1023 5.36e-22 99.4 COG0388@1|root,COG0454@1|root,COG0388@2|Bacteria,COG0456@2|Bacteria,1TQAZ@1239|Firmicutes,4HCQW@91061|Bacilli,1ZB16@1386|Bacillus 91061|Bacilli K Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase yhcX - - - - - - - - - - - Acetyltransf_1,CN_hydrolase k59_1443670_1 1283284.AZUK01000001_gene2299 3.04e-83 263.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1Y3VZ@135624|Aeromonadales 135624|Aeromonadales J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_967506_1 344747.PM8797T_30886 1.95e-79 253.0 COG2230@1|root,COG2230@2|Bacteria,2IZUD@203682|Planctomycetes 203682|Planctomycetes M Mycolic acid cyclopropane synthetase - - - - - - - - - - - - CMAS k59_342557_1 502025.Hoch_4147 2.41e-57 199.0 COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales 28221|Deltaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2 k59_1174323_1 1327990.S0A3W7_9CAUD 2.67e-32 119.0 4QDZK@10239|Viruses,4QZ0R@35237|dsDNA viruses no RNA stage,4QRNK@28883|Caudovirales,4QNPJ@10744|Podoviridae 10744|Podoviridae S AAA domain - - - - - - - - - - - - - k59_550683_1 402881.Plav_1154 3.16e-97 303.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2TRND@28211|Alphaproteobacteria,1JNP8@119043|Rhodobiaceae 28211|Alphaproteobacteria I Acetyl-coenzyme A synthetase N-terminus - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_506332_1 1380394.JADL01000004_gene5768 1.28e-137 402.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria,2JQ46@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_709817_2 469383.Cwoe_4723 9.79e-72 228.0 COG3496@1|root,COG3496@2|Bacteria,2HR57@201174|Actinobacteria,4CT0I@84995|Rubrobacteria 84995|Rubrobacteria S Protein of unknown function (DUF1365) - - - ko:K09701 - - - - ko00000 - - - DUF1365 k59_1075183_1 1304875.JAFZ01000001_gene939 1.97e-49 167.0 COG4866@1|root,COG4866@2|Bacteria,3TB1A@508458|Synergistetes 508458|Synergistetes S Uncharacterised conserved protein (DUF2156) - - - ko:K01163 - - - - ko00000 - - - DUF2156 k59_1386036_1 641526.ADIWIN_1124 1.2e-11 70.9 COG1409@1|root,COG3897@1|root,COG1409@2|Bacteria,COG3897@2|Bacteria,4NGK2@976|Bacteroidetes,1I0BV@117743|Flavobacteriia 976|Bacteroidetes M Purple acid Phosphatase, N-terminal domain - - - - - - - - - - - - Metallophos,Pur_ac_phosph_N k59_266731_1 391896.A1I_00315 2.07e-78 244.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2TRP3@28211|Alphaproteobacteria,47EY3@766|Rickettsiales 766|Rickettsiales H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_1311216_1 335543.Sfum_1527 2.76e-38 140.0 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,42PNZ@68525|delta/epsilon subdivisions,2WM13@28221|Deltaproteobacteria,2MQS1@213462|Syntrophobacterales 28221|Deltaproteobacteria C CoA-transferase family III - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_1415807_1 397278.JOJN01000006_gene1125 3.86e-16 85.5 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2HEZR@201174|Actinobacteria,4DV1I@85009|Propionibacteriales 201174|Actinobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - AAA_16,Guanylate_cyc k59_1102549_1 10116.ENSRNOP00000026965 1.01e-27 109.0 COG1618@1|root,2QVJ8@2759|Eukaryota,38FT1@33154|Opisthokonta,3BGUB@33208|Metazoa,3CSDG@33213|Bilateria,482RA@7711|Chordata,493VV@7742|Vertebrata,3J53W@40674|Mammalia,35RQU@314146|Euarchontoglires,4Q9FF@9989|Rodentia 33208|Metazoa F NTPase NTPCR - 3.6.1.15 ko:K06928 ko00230,ko00730,ko01100,map00230,map00730,map01100 - R00086,R00615 RC00002 ko00000,ko00001,ko01000 - - - NTPase_1 k59_1624738_1 1282876.BAOK01000001_gene3578 5.29e-66 216.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2TW0G@28211|Alphaproteobacteria,4BTG2@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Reductase C-terminal - - 1.18.1.3 ko:K00529 ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220 M00545 R02000,R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Pyr_redox_2,Reductase_C,Rieske k59_214304_1 1283300.ATXB01000001_gene2341 1.21e-102 301.0 COG3335@1|root,COG3335@2|Bacteria,1N5WI@1224|Proteobacteria,1S5TZ@1236|Gammaproteobacteria,1XF5S@135618|Methylococcales 135618|Methylococcales L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_214304_2 1283300.ATXB01000001_gene1137 2.13e-55 179.0 COG3415@1|root,COG3415@2|Bacteria,1QVAE@1224|Proteobacteria,1T533@1236|Gammaproteobacteria,1XGNF@135618|Methylococcales 135618|Methylococcales L Winged helix-turn helix - - - - - - - - - - - - HTH_32 k59_736700_1 1242864.D187_008306 7.28e-99 308.0 COG0569@1|root,COG1226@1|root,COG0569@2|Bacteria,COG1226@2|Bacteria,1R4J8@1224|Proteobacteria,42NKU@68525|delta/epsilon subdivisions,2WIRH@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Ion transport 2 domain protein - - - - - - - - - - - - Ion_trans_2,TrkA_C,TrkA_N k59_841257_1 1453503.AU05_20220 5.16e-30 119.0 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,1RQKR@1236|Gammaproteobacteria,1YFJP@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Belongs to the GcvT family soxA - 1.5.3.1 ko:K00302 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2 k59_841257_2 667632.KB890182_gene884 7.35e-95 306.0 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2VK5U@28216|Betaproteobacteria,1K4EZ@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the GcvT family soxA - 1.5.3.1 ko:K00302 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2 k59_423354_1 1123072.AUDH01000002_gene2315 6.56e-17 81.3 COG0154@1|root,COG0154@2|Bacteria,1MU51@1224|Proteobacteria,2TSYS@28211|Alphaproteobacteria,2JQZT@204441|Rhodospirillales 204441|Rhodospirillales J Amidase - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_423354_2 472759.Nhal_2615 3.59e-05 45.1 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,1WWKJ@135613|Chromatiales 135613|Chromatiales E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) - - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_214309_1 1229909.NSED_01190 1.16e-103 315.0 COG1053@1|root,arCOG00571@2157|Archaea,41SAM@651137|Thaumarchaeota 651137|Thaumarchaeota C fumarate reductase flavoprotein - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1208407_2 261292.Nit79A3_1960 6.94e-12 68.2 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,3720B@32003|Nitrosomonadales 28216|Betaproteobacteria M Belongs to the peptidase S1C family degQ - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1468644_1 314278.NB231_00245 1.22e-60 210.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1X08T@135613|Chromatiales 135613|Chromatiales M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_1468644_2 1224136.AMFN01000004_gene1703 4.81e-05 45.4 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria,2837I@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0042380,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046490,GO:0048037,GO:0051536,GO:0051538,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - iECIAI1_1343.ECIAI1_0030,iECW_1372.ECW_m0028,iEKO11_1354.EKO11_3884,iEcHS_1320.EcHS_A0031,iEcolC_1368.EcolC_3626,iPC815.YPO0477,iSFV_1184.SFV_0023,iSF_1195.SF0026,iSFxv_1172.SFxv_0027,iS_1188.S0028,iWFL_1372.ECW_m0028,iYL1228.KPN_00024 LYTB k59_475491_1 323261.Noc_1825 6.64e-73 242.0 COG1452@1|root,COG1452@2|Bacteria,1QW3G@1224|Proteobacteria,1T2RD@1236|Gammaproteobacteria,1WWPC@135613|Chromatiales 135613|Chromatiales M involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - - - - - - - - - - - k59_319334_1 96561.Dole_2696 0.0 942.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MHW3@213118|Desulfobacterales 28221|Deltaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_685813_1 911045.PSE_0437 4.85e-132 390.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQQH@28211|Alphaproteobacteria 28211|Alphaproteobacteria E ABC-type dipeptide transport system periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_371136_1 1121405.dsmv_3379 6.84e-44 144.0 COG0695@1|root,COG0695@2|Bacteria,1NAZM@1224|Proteobacteria,42VIA@68525|delta/epsilon subdivisions,2WR8X@28221|Deltaproteobacteria,2MKPI@213118|Desulfobacterales 28221|Deltaproteobacteria O PFAM Glutaredoxin - - - ko:K06191 - - - - ko00000 - - - Glutaredoxin k59_371136_2 1121405.dsmv_3380 1.48e-57 180.0 COG4802@1|root,COG4802@2|Bacteria,1RI70@1224|Proteobacteria,42SXJ@68525|delta/epsilon subdivisions,2WP19@28221|Deltaproteobacteria,2MKJ4@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Ferredoxin thioredoxin reductase catalytic beta chain - - - - - - - - - - - - FeThRed_B k59_59088_1 485916.Dtox_2592 4.66e-19 86.7 COG0697@1|root,COG0697@2|Bacteria,1U3VF@1239|Firmicutes,25AUI@186801|Clostridia,265HE@186807|Peptococcaceae 186801|Clostridia EG EamA-like transporter family - - - - - - - - - - - - EamA k59_893704_2 1121033.AUCF01000014_gene1319 5.51e-102 311.0 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,2JPED@204441|Rhodospirillales 204441|Rhodospirillales I acetyl-coa acetyltransferase - - - - - - - - - - - - Thiolase_C k59_790319_1 768671.ThimaDRAFT_2297 6.75e-15 69.7 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1WZ2Z@135613|Chromatiales 135613|Chromatiales K PFAM Cold-shock protein, DNA-binding - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_633730_1 518766.Rmar_0089 5.51e-90 288.0 COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1FIP6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Peptidase M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_841272_1 439235.Dalk_0052 2.75e-59 206.0 COG0531@1|root,COG3064@1|root,COG0531@2|Bacteria,COG3064@2|Bacteria,1R4IZ@1224|Proteobacteria,42MTQ@68525|delta/epsilon subdivisions,2WK39@28221|Deltaproteobacteria,2MIIG@213118|Desulfobacterales 28221|Deltaproteobacteria E Amino acid permease - - - - - - - - - - - - AA_permease,SLC12 k59_633731_1 1120999.JONM01000010_gene4105 4.85e-98 307.0 COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,2VKA1@28216|Betaproteobacteria 28216|Betaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_790322_1 1219077.VAZ01S_023_00280 0.000974 46.6 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,1XW4M@135623|Vibrionales 135623|Vibrionales S AAA domain (dynein-related subfamily) cobS - 6.6.1.2 ko:K09882 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - AAA_5,CbbQ_C,CobS_N k59_1154667_1 497964.CfE428DRAFT_2150 2.97e-35 132.0 COG1235@1|root,COG1235@2|Bacteria,46VEV@74201|Verrucomicrobia 74201|Verrucomicrobia S May be involved in the transport of PQQ or its precursor to the periplasm pqqB - - ko:K06136 - - - - ko00000 - - - Lactamase_B_2 k59_1154667_2 765912.Thimo_0438 7.66e-77 259.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria,1X2HJ@135613|Chromatiales 135613|Chromatiales I acyl-CoA dehydrogenase - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N,AcylCoA_dehyd_C k59_475513_1 1123073.KB899241_gene2058 4.91e-15 68.9 2EGSV@1|root,33AIZ@2|Bacteria,1NGPG@1224|Proteobacteria,1SGM3@1236|Gammaproteobacteria,1X8YC@135614|Xanthomonadales 135614|Xanthomonadales S Cysteine-rich CPXCG - - - - - - - - - - - - Cys_rich_CPXG k59_475513_2 383381.EH30_13575 8.31e-12 67.8 COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,2U668@28211|Alphaproteobacteria,2K48S@204457|Sphingomonadales 204457|Sphingomonadales S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B,Lactamase_B_2 k59_214336_1 237368.SCABRO_03725 5.63e-126 368.0 COG1697@1|root,COG1697@2|Bacteria,2J34C@203682|Planctomycetes 203682|Planctomycetes L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6A - 5.99.1.3 ko:K03166 - - - - ko00000,ko01000,ko03032 - - - TP6A_N k59_371148_1 1282876.BAOK01000001_gene2864 4.33e-36 131.0 COG4221@1|root,COG4221@2|Bacteria,1RAKI@1224|Proteobacteria,2TUJT@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_371148_2 1229780.BN381_130241 5.12e-101 306.0 COG2220@1|root,COG2220@2|Bacteria,2GMFQ@201174|Actinobacteria 201174|Actinobacteria S Zn-dependent hydrolases of the beta-lactamase fold - - - - - - - - - - - - Lactamase_B_3 k59_1208447_1 365044.Pnap_2180 6.78e-62 211.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4A9J4@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_59127_1 706587.Desti_1526 6.25e-53 181.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,42MN3@68525|delta/epsilon subdivisions,2WMHC@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_1518607_1 1510531.JQJJ01000012_gene1571 4.5e-14 70.9 COG0400@1|root,COG0400@2|Bacteria,1MUKQ@1224|Proteobacteria,2TUA0@28211|Alphaproteobacteria,3JTR9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Phospholipase/Carboxylesterase - - - ko:K06999 - - - - ko00000 - - - Abhydrolase_1,Abhydrolase_2 k59_1311274_1 1192034.CAP_0497 1.72e-14 75.1 COG1028@1|root,COG1028@2|Bacteria,1MWJQ@1224|Proteobacteria,433VV@68525|delta/epsilon subdivisions,2X3QJ@28221|Deltaproteobacteria,2YWUM@29|Myxococcales 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_1311274_2 1206732.BAGD01000096_gene4073 2.86e-33 122.0 COG0748@1|root,COG0748@2|Bacteria,2IIRT@201174|Actinobacteria,4G1BG@85025|Nocardiaceae 201174|Actinobacteria P F420H(2)-dependent quinone reductase - - - - - - - - - - - - F420H2_quin_red k59_790352_1 1229909.NSED_04350 7.06e-49 171.0 COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota 651137|Thaumarchaeota T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,dCache_1 k59_266799_1 1125973.JNLC01000001_gene23 4.27e-30 122.0 COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,2TU4M@28211|Alphaproteobacteria,3JVB8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_1572283_1 1229780.BN381_50055 1.17e-12 67.8 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,3UWBH@52018|unclassified Actinobacteria (class) 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family feaB - 1.2.1.3,1.2.1.39,1.2.1.8 ko:K00128,ko:K00130,ko:K00146 ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130 M00135,M00555 R00264,R00631,R00710,R00904,R01752,R01986,R02536,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1572283_2 768671.ThimaDRAFT_0093 3.78e-46 166.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1WWEZ@135613|Chromatiales 135613|Chromatiales H Catalyzes the oxidation of L-aspartate to iminoaspartate - - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1468696_1 1123393.KB891327_gene348 1.06e-84 258.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2VHGK@28216|Betaproteobacteria,1KSY4@119069|Hydrogenophilales 119069|Hydrogenophilales S Pirin C-terminal cupin domain - - - - - - - - - - - - Pirin,Pirin_C k59_59135_2 177437.HRM2_02710 1.06e-46 163.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2MIT8@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_841303_1 1429916.X566_14905 9.04e-61 195.0 COG0596@1|root,COG0596@2|Bacteria,1NUT9@1224|Proteobacteria,2TVMS@28211|Alphaproteobacteria,3JT3H@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 k59_841303_2 477184.KYC_08760 2.57e-40 137.0 COG3255@1|root,COG3255@2|Bacteria,1RG3A@1224|Proteobacteria,2VX1T@28216|Betaproteobacteria,3T80I@506|Alcaligenaceae 28216|Betaproteobacteria I Sterol carrier protein - - - - - - - - - - - - - k59_214355_1 977880.RALTA_B1427 1.58e-48 172.0 COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2VICE@28216|Betaproteobacteria,1KC56@119060|Burkholderiaceae 28216|Betaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B,NUDIX k59_423394_2 445686.E3SL18_9CAUD 2.32e-255 721.0 4QHQV@10239|Viruses,4QX6C@35237|dsDNA viruses no RNA stage,4QRJ7@28883|Caudovirales,4QIJU@10662|Myoviridae 10662|Myoviridae S virus tail assembly - - - - - - - - - - - - - k59_633775_1 1179773.BN6_27770 1.74e-123 386.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4DYUS@85010|Pseudonocardiales 201174|Actinobacteria E Methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_790363_1 1283300.ATXB01000001_gene1465 6.81e-56 195.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1XE8F@135618|Methylococcales 135618|Methylococcales M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) - - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_685877_1 981369.JQMJ01000004_gene773 0.000638 42.0 COG0053@1|root,COG0053@2|Bacteria,2IFJP@201174|Actinobacteria,2NNE9@228398|Streptacidiphilus 201174|Actinobacteria P Cation efflux family - - - - - - - - - - - - Cation_efflux k59_685877_2 290397.Adeh_3396 2.24e-43 156.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WIQG@28221|Deltaproteobacteria,2YUFQ@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1260584_1 1279017.AQYJ01000026_gene240 5.46e-20 88.2 COG2974@1|root,COG2974@2|Bacteria,1MXPR@1224|Proteobacteria,1RMNN@1236|Gammaproteobacteria,4650K@72275|Alteromonadaceae 1236|Gammaproteobacteria L May be involved in recombination rdgC GO:0000018,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009295,GO:0019219,GO:0019222,GO:0031323,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363 - ko:K03554 - - - - ko00000,ko03400 - - - RdgC k59_371683_2 1444770.AF72_05515 1.21e-31 122.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1X2YF@135614|Xanthomonadales 135614|Xanthomonadales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_894304_1 1144275.COCOR_01074 9.25e-121 359.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2YU6I@29|Myxococcales 28221|Deltaproteobacteria I Carboxyl transferase domain pccB - 2.1.3.1,2.1.3.15,6.4.1.3 ko:K01966,ko:K17489 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R00353,R01859 RC00040,RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_894304_2 412597.AEPN01000015_gene1221 1.93e-58 200.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2PVCD@265|Paracoccus 28211|Alphaproteobacteria I Biotin carboxylase C-terminal domain pccA - 6.4.1.3 ko:K01965 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_423968_2 765914.ThisiDRAFT_2338 1.46e-36 129.0 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,1S668@1236|Gammaproteobacteria,1WYAA@135613|Chromatiales 135613|Chromatiales G PTS IIA-like nitrogen-regulatory protein PtsN - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_528235_1 1202962.KB907169_gene2441 1.88e-36 133.0 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,1RN90@1236|Gammaproteobacteria 1236|Gammaproteobacteria NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue pilD - 3.4.23.43 ko:K02464,ko:K02654 ko03070,map03070 M00331 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15,3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_528235_2 395493.BegalDRAFT_2978 2.63e-35 131.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,45ZY3@72273|Thiotrichales 72273|Thiotrichales U PFAM Bacterial type II secretion system protein F domain pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_1364217_1 316274.Haur_0997 1.19e-144 421.0 COG1262@1|root,COG1262@2|Bacteria,2G89M@200795|Chloroflexi 200795|Chloroflexi S Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - DinB_2,FGE-sulfatase k59_423973_1 1192868.CAIU01000020_gene2803 4.42e-16 81.3 COG4608@1|root,COG4608@2|Bacteria,1NVR1@1224|Proteobacteria,2U6NM@28211|Alphaproteobacteria,43HT6@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_1625345_1 530564.Psta_3292 5.53e-123 367.0 COG0129@1|root,COG0129@2|Bacteria,2IWXV@203682|Planctomycetes 203682|Planctomycetes H Belongs to the IlvD Edd family ilvD GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_371704_1 1255043.TVNIR_0922 2.16e-12 66.6 2DB88@1|root,2Z7QT@2|Bacteria,1R0WJ@1224|Proteobacteria,1T0TT@1236|Gammaproteobacteria,1X2MU@135613|Chromatiales 1224|Proteobacteria S Domain of unknown function (DUF4338) - - - - - - - - - - - - DUF4338 k59_160908_1 439235.Dalk_3911 4.61e-33 129.0 COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1QV6D@1224|Proteobacteria 1224|Proteobacteria I 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III - - - - - - - - - - - - ACP_syn_III_C,DUF35_N,OB_aCoA_assoc k59_528251_1 391615.ABSJ01000050_gene1159 2.07e-23 100.0 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1J5XC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) IV02_10730 - - - - - - - - - - - DUF58 k59_1519017_1 316067.Geob_3308 2.57e-34 138.0 COG2373@1|root,COG3291@1|root,COG5276@1|root,COG2373@2|Bacteria,COG3291@2|Bacteria,COG5276@2|Bacteria,1R7A1@1224|Proteobacteria,42Y4U@68525|delta/epsilon subdivisions,2WU72@28221|Deltaproteobacteria 28221|Deltaproteobacteria U IgGFc binding protein - - - - - - - - - - - - Big_1,IgGFc_binding k59_634550_1 296587.XP_002499432.1 1.91e-34 132.0 COG1210@1|root,2QPZV@2759|Eukaryota,37YH8@33090|Viridiplantae,34J1M@3041|Chlorophyta 3041|Chlorophyta M GHMP kinases N terminal domain - - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_N k59_267396_2 585531.HMPREF0063_11479 3.38e-36 140.0 COG0657@1|root,COG0657@2|Bacteria,2GKX2@201174|Actinobacteria,4DP5K@85009|Propionibacteriales 201174|Actinobacteria I PFAM Alpha beta hydrolase fold-3 domain protein - - - ko:K01066 - - - - ko00000,ko01000 - - - Abhydrolase_3 k59_686636_1 118163.Ple7327_2483 7.35e-38 140.0 COG0392@1|root,COG0392@2|Bacteria,1G3F6@1117|Cyanobacteria,3VJ9D@52604|Pleurocapsales 1117|Cyanobacteria S PFAM Uncharacterised protein family (UPF0104) - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - DUF2156,LPG_synthase_TM k59_110139_1 1485545.JQLW01000006_gene297 1.19e-64 225.0 COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria 1224|Proteobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,Pkinase k59_894344_1 861299.J421_3811 1.19e-34 134.0 COG1640@1|root,COG1640@2|Bacteria,1ZU23@142182|Gemmatimonadetes 142182|Gemmatimonadetes G 4-alpha-glucanotransferase - - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_3139_1 436308.Nmar_0738 7.63e-30 109.0 COG1522@1|root,arCOG01580@2157|Archaea,41T4E@651137|Thaumarchaeota 651137|Thaumarchaeota K helix_turn_helix ASNC type - - - - - - - - - - - - AsnC_trans_reg,HTH_AsnC-type k59_998284_1 436308.Nmar_1110 1.49e-78 241.0 COG1454@1|root,arCOG00984@2157|Archaea,41SFC@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Iron-containing alcohol dehydrogenase - - - ko:K18602 ko00720,ko01120,map00720,map01120 - R09289 RC00087 ko00000,ko00001,ko01000 - - - Fe-ADH k59_998284_2 1229909.NSED_06445 1.04e-43 154.0 COG2379@1|root,arCOG04170@2157|Archaea,41SJF@651137|Thaumarchaeota 651137|Thaumarchaeota G MOFRL family - - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_894355_1 685727.REQ_15590 3.17e-92 300.0 COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,4FW1X@85025|Nocardiaceae 201174|Actinobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_530728_1 502025.Hoch_5960 1.73e-42 154.0 COG1752@1|root,COG1752@2|Bacteria,1PEH4@1224|Proteobacteria,42XKH@68525|delta/epsilon subdivisions,2WTA6@28221|Deltaproteobacteria,2YUHG@29|Myxococcales 28221|Deltaproteobacteria S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1314169_1 485913.Krac_6399 5.13e-06 55.8 COG3385@1|root,COG3385@2|Bacteria,2G9A6@200795|Chloroflexi 200795|Chloroflexi L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_896793_1 158787.BSCA_1379 1.7e-07 57.0 COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria,4D0BY@85004|Bifidobacteriales 201174|Actinobacteria I Psort location CytoplasmicMembrane, score 9.99 yrhL - - - - - - - - - - - Acyl_transf_3 k59_948204_1 1235457.C404_17980 7.69e-20 92.4 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2VHJ9@28216|Betaproteobacteria,1JZYM@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM peptidase U62 modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_530732_1 1307761.L21SP2_1019 3.48e-92 291.0 COG0010@1|root,COG3457@1|root,COG0010@2|Bacteria,COG3457@2|Bacteria,2JA1N@203691|Spirochaetes 203691|Spirochaetes E Alanine racemase, N-terminal domain - - 5.1.1.12 ko:K21898 ko00472,map00472 - R00672 RC00302 ko00000,ko00001,ko01000 - - - Ala_racemase_N k59_1418869_2 1203568.HMPREF1484_00358 0.000212 48.9 COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,4FBMZ@85020|Dermabacteraceae 201174|Actinobacteria K helix_turn_helix, cAMP Regulatory protein glxR GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1212353_1 1125863.JAFN01000001_gene2409 2.1e-40 149.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria 28221|Deltaproteobacteria C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M nuoM-1 - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_1157526_1 290400.Jann_2272 2.22e-44 158.0 COG2124@1|root,COG2124@2|Bacteria,1N0PF@1224|Proteobacteria,2UD84@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome P450 - - - - - - - - - - - - p450 k59_1418872_1 1173028.ANKO01000219_gene503 3.73e-46 170.0 COG0659@1|root,COG0659@2|Bacteria,1G0NU@1117|Cyanobacteria,1H8BM@1150|Oscillatoriales 1117|Cyanobacteria P Sulfate permease family sulP - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_637742_1 316274.Haur_2169 3.06e-10 66.6 COG0028@1|root,COG2911@1|root,COG2931@1|root,COG3055@1|root,COG3266@1|root,COG3386@1|root,COG3409@1|root,COG0028@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3055@2|Bacteria,COG3266@2|Bacteria,COG3386@2|Bacteria,COG3409@2|Bacteria,2G9CG@200795|Chloroflexi,374U7@32061|Chloroflexia 32061|Chloroflexia G LamG domain protein jellyroll fold domain protein - - - - - - - - - - - - Big_3_3,Laminin_G_3 k59_739681_1 105559.Nwat_0606 1.47e-99 321.0 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,1WW6H@135613|Chromatiales 135613|Chromatiales F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_163226_1 298653.Franean1_3545 1.18e-41 143.0 COG3411@1|root,COG3411@2|Bacteria,2IG3E@201174|Actinobacteria 201174|Actinobacteria C Ferredoxin - - - - - - - - - - - - - k59_844427_1 102125.Xen7305DRAFT_00028620 2.34e-64 211.0 COG3547@1|root,COG3547@2|Bacteria,1G077@1117|Cyanobacteria,3VNMH@52604|Pleurocapsales 1117|Cyanobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_896814_1 713586.KB900536_gene1841 9.01e-195 587.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_217545_1 225849.swp_0941 7.2e-30 113.0 COG1863@1|root,COG1863@2|Bacteria,1MZYJ@1224|Proteobacteria,1S7Z3@1236|Gammaproteobacteria,2QBMS@267890|Shewanellaceae 1236|Gammaproteobacteria P PFAM cation antiporter mnhE - - ko:K05569 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MNHE k59_1628029_1 1229909.NSED_06235 4.12e-36 124.0 arCOG11451@1|root,arCOG11451@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1053448_1 1394178.AWOO02000072_gene443 6.42e-50 168.0 COG1024@1|root,COG1024@2|Bacteria,2GKC4@201174|Actinobacteria 201174|Actinobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - - - - - - - - - - - ECH_1 k59_1628035_1 314278.NB231_02123 0.000996 41.2 COG0431@1|root,COG0431@2|Bacteria,1RH7F@1224|Proteobacteria,1T04E@1236|Gammaproteobacteria,1X2KR@135613|Chromatiales 135613|Chromatiales S Flavodoxin-like fold - - - - - - - - - - - - FMN_red k59_1628035_2 1123514.KB905900_gene2142 4.18e-88 271.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,4607K@72273|Thiotrichales 72273|Thiotrichales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_739701_1 929703.KE386491_gene1932 3.22e-100 305.0 COG1260@1|root,COG1260@2|Bacteria,4NI0F@976|Bacteroidetes 976|Bacteroidetes I Inositol-3-phosphate synthase ino1 - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth,NAD_binding_5 k59_1053462_1 1148.1652093 6.67e-21 91.7 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1G0XM@1117|Cyanobacteria,1H6E0@1142|Synechocystis 1117|Cyanobacteria E GXGXG motif gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.7.1 ko:K00284 ko00630,ko00910,ko01120,map00630,map00910,map01120 - R00021,R10086 RC00006,RC00010 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1053462_2 1120998.AUFC01000006_gene927 2.24e-16 77.4 COG1522@1|root,COG1522@2|Bacteria,1V88V@1239|Firmicutes,24GG4@186801|Clostridia 186801|Clostridia K helix_turn_helix ASNC type - - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_794560_1 298655.KI912266_gene1799 1.31e-09 62.8 COG0438@1|root,COG0438@2|Bacteria,2I958@201174|Actinobacteria 201174|Actinobacteria M Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_794560_2 1112204.GPOL_c47840 4.37e-103 313.0 COG5361@1|root,COG5361@2|Bacteria,2HES3@201174|Actinobacteria,4GH56@85026|Gordoniaceae 201174|Actinobacteria S Protein of unknown function (DUF1214) - - - - - - - - - - - - DUF1214 k59_1264544_1 644282.Deba_2787 3.18e-93 300.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Penicillin-binding protein, dimerisation domain ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase k59_322671_2 378806.STAUR_6386 2.37e-17 83.6 COG3794@1|root,COG3794@2|Bacteria,1QTJB@1224|Proteobacteria,438FG@68525|delta/epsilon subdivisions,2X3QG@28221|Deltaproteobacteria,2YWUH@29|Myxococcales 28221|Deltaproteobacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - - k59_794563_1 1229909.NSED_09705 1.05e-152 435.0 COG1405@1|root,arCOG01981@2157|Archaea 2157|Archaea K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) tfb - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon k59_1418927_1 706587.Desti_4374 8.28e-56 184.0 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2WMXB@28221|Deltaproteobacteria,2MQDY@213462|Syntrophobacterales 28221|Deltaproteobacteria L Uracil DNA glycosylase superfamily - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1000388_1 519989.ECTPHS_06952 1.52e-47 171.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales 135613|Chromatiales L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_269924_1 1380394.JADL01000001_gene2973 1.4e-65 218.0 COG2271@1|root,COG2271@2|Bacteria,1QU9E@1224|Proteobacteria,2TWHH@28211|Alphaproteobacteria,2JR0J@204441|Rhodospirillales 204441|Rhodospirillales G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1628052_1 444860.E3SJ63_9CAUD 1.09e-185 536.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QI6A@10662|Myoviridae 10662|Myoviridae S Ribonucleotide reductase, barrel domain - - - - - - - - - - - - - k59_896844_1 1120936.KB907209_gene1431 1.55e-89 280.0 COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria,4EHBF@85012|Streptosporangiales 201174|Actinobacteria C FAD linked oxidases, C-terminal domain agpS - 2.5.1.26 ko:K00803 ko00565,ko01100,ko04146,map00565,map01100,map04146 - R04311 RC00020,RC02886 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1105805_1 1278309.KB907100_gene2212 6.46e-57 194.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,1RME6@1236|Gammaproteobacteria,1XIYC@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the formate--tetrahydrofolate ligase family fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_112416_2 436308.Nmar_0475 1.78e-77 239.0 COG1131@1|root,arCOG00194@2157|Archaea,41TB9@651137|Thaumarchaeota 651137|Thaumarchaeota V Domain of unknown function (DUF4162) - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_896849_1 1247024.JRLH01000010_gene1150 8.18e-23 97.8 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria 1236|Gammaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_896849_2 279010.BL01745 1.25e-11 70.1 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UMK7@1239|Firmicutes,4H9QN@91061|Bacilli,1ZHTW@1386|Bacillus 91061|Bacilli T helix_turn_helix, arabinose operon control protein - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,Response_reg k59_844464_1 1123257.AUFV01000014_gene3414 6.98e-46 154.0 COG4539@1|root,COG4539@2|Bacteria,1N1G8@1224|Proteobacteria,1S9FD@1236|Gammaproteobacteria,1X6EP@135614|Xanthomonadales 135614|Xanthomonadales S membrane - - - - - - - - - - - - DUF962 k59_322687_1 1196322.A370_03066 1.01e-58 187.0 COG2818@1|root,COG2818@2|Bacteria,1UYWG@1239|Firmicutes,249EP@186801|Clostridia,36J4Q@31979|Clostridiaceae 186801|Clostridia L DNA-3-methyladenine glycosylase I tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_530801_1 1229909.NSED_00040 1.04e-56 186.0 COG0457@1|root,arCOG03032@2157|Archaea,41T0V@651137|Thaumarchaeota 651137|Thaumarchaeota S Tetratricopeptide repeat - - - - - - - - - - - - TPR_1 k59_1418947_1 330214.NIDE1572 2.76e-35 124.0 COG1977@1|root,COG1977@2|Bacteria 2|Bacteria H Mo-molybdopterin cofactor metabolic process moaD - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_1418947_2 330214.NIDE1571 3.43e-65 201.0 COG0315@1|root,COG0315@2|Bacteria,3J0PN@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC k59_1213469_1 1268068.PG5_33900 6.34e-37 138.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,1S758@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family crt - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_795852_1 981336.F944_01180 1.69e-40 142.0 COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,1S5WA@1236|Gammaproteobacteria,3NJ0Z@468|Moraxellaceae 1236|Gammaproteobacteria O Thiol disulfide interchange protein dsbA - - ko:K03673 ko01503,map01503 M00728 - - ko00000,ko00001,ko00002,ko03110 - - - DSBA k59_795852_2 1300345.LF41_1643 1.86e-40 143.0 COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,1T15C@1236|Gammaproteobacteria,1XD33@135614|Xanthomonadales 135614|Xanthomonadales S to the N-terminal domain of Lon protease - - - ko:K07157 - - - - ko00000 - - - LON_substr_bdg k59_113336_1 751994.AGIG01000035_gene357 9.77e-90 283.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1J7VQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F 5'-nucleotidase, C-terminal domain soxB - - ko:K17224 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - 5_nucleotid_C k59_531720_1 204669.Acid345_1524 2.41e-53 188.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,3Y40G@57723|Acidobacteria,2JIXP@204432|Acidobacteriia 204432|Acidobacteriia T Signal transducing histidine kinase, homodimeric domain - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_1576095_1 768066.HELO_3505 3.49e-27 107.0 COG4067@1|root,COG4067@2|Bacteria,1RFKA@1224|Proteobacteria,1S40X@1236|Gammaproteobacteria,1XP6P@135619|Oceanospirillales 135619|Oceanospirillales O protein conserved in archaea - - - - - - - - - - - - Zn_protease k59_1576095_2 187272.Mlg_0770 1.43e-09 62.0 COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,1RRIA@1236|Gammaproteobacteria,1X0CC@135613|Chromatiales 135613|Chromatiales E 7 transmembrane helices usually fused to an inactive transglutaminase - - - - - - - - - - - - 7TM_transglut,Transglut_i_TM k59_375407_1 67267.JNXT01000020_gene6855 3.86e-66 211.0 COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.3.1.33 ko:K00218 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03845,R06286 RC01008 ko00000,ko00001,ko01000 - - - adh_short k59_164191_1 1278309.KB907099_gene2912 6.37e-100 303.0 COG2132@1|root,COG2132@2|Bacteria,1R89G@1224|Proteobacteria,1S5X0@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_3 k59_531725_1 861450.HMPREF0080_00958 3.07e-14 67.8 COG0211@1|root,COG0211@2|Bacteria,1V6HW@1239|Firmicutes,4H4PT@909932|Negativicutes 909932|Negativicutes J Belongs to the bacterial ribosomal protein bL27 family rpmA - - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_1629079_1 1122134.KB893650_gene1338 9.61e-29 117.0 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,1RPEQ@1236|Gammaproteobacteria,1XRCB@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_218528_1 1229909.NSED_08945 1.74e-108 338.0 COG4257@1|root,arCOG06267@1|root,arCOG03564@2157|Archaea,arCOG06267@2157|Archaea,41S5S@651137|Thaumarchaeota 651137|Thaumarchaeota V resistance protein - - - ko:K14166 - - - - ko00000,ko02000 - - - CopC,CopD k59_427493_1 1008457.BAEX01000006_gene899 1.26e-131 409.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,4NFRF@976|Bacteroidetes,1INDD@117743|Flavobacteriia,47IN6@76831|Myroides 976|Bacteroidetes E B12 binding domain metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_531729_1 44251.PDUR_27415 1.8e-08 62.0 COG3973@1|root,COG3973@2|Bacteria,1TP39@1239|Firmicutes,4H9Y5@91061|Bacilli,26SY8@186822|Paenibacillaceae 91061|Bacilli L DNA helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_19,UvrD-helicase,UvrD_C,UvrD_C_2 k59_480062_1 926569.ANT_07310 4.8e-42 147.0 COG0500@1|root,COG0537@1|root,COG0500@2|Bacteria,COG0537@2|Bacteria,2G6SB@200795|Chloroflexi 200795|Chloroflexi FG Histidine triad (HIT) protein - - 2.7.7.53 ko:K19710 ko00230,map00230 - R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 - - - HIT,NUDIX k59_639016_2 1232410.KI421425_gene1564 4.42e-52 177.0 COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42PIE@68525|delta/epsilon subdivisions,2WM3C@28221|Deltaproteobacteria,43SBI@69541|Desulfuromonadales 28221|Deltaproteobacteria C Polysulphide reductase, NrfD moz - - ko:K00185 - - - - ko00000 5.A.3 - - DUF3341,NrfD k59_427503_1 1112274.KI911560_gene626 3.51e-23 92.4 COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,2VR62@28216|Betaproteobacteria,2KMKZ@206350|Nitrosomonadales 206350|Nitrosomonadales O OsmC-like protein - - - ko:K07397 - - - - ko00000 - - - OsmC k59_427503_2 203122.Sde_0755 3.91e-25 99.8 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria,465GT@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases crp GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007584,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019222,GO:0019438,GO:0030551,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0032553,GO:0032555,GO:0032561,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0035438,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045013,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045990,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0061984,GO:0061985,GO:0065007,GO:0070887,GO:0071496,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140110,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - Crp,cNMP_binding k59_323643_1 1266925.JHVX01000018_gene1825 2.34e-29 113.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2VH5D@28216|Betaproteobacteria,372HU@32003|Nitrosomonadales 28216|Betaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_113362_1 485913.Krac_7237 3.1e-138 406.0 COG1262@1|root,COG1262@2|Bacteria,2G89M@200795|Chloroflexi 200795|Chloroflexi S Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - DinB_2,FGE-sulfatase k59_164218_1 589865.DaAHT2_1602 4.69e-55 184.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,42T7F@68525|delta/epsilon subdivisions,2WP8W@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_1265764_1 985665.HPL003_03185 2.74e-39 142.0 COG3638@1|root,COG3638@2|Bacteria,1TQG6@1239|Firmicutes,4HC3N@91061|Bacilli,26S0C@186822|Paenibacillaceae 91061|Bacilli P Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system phnC GO:0006810,GO:0008150,GO:0015716,GO:0051179,GO:0051234,GO:0071702 3.6.3.28 ko:K02041 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.9 - - ABC_tran k59_480080_1 1349767.GJA_2100 3.32e-31 118.0 2DNTZ@1|root,32Z4F@2|Bacteria,1NA30@1224|Proteobacteria 1224|Proteobacteria - - - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - - k59_1054451_1 525282.HMPREF0391_11165 1.45e-24 102.0 COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,22GMA@1570339|Peptoniphilaceae 186801|Clostridia J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 trmU - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_1054451_2 522306.CAP2UW1_2937 8.79e-56 178.0 COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,2VRC0@28216|Betaproteobacteria,1KQZW@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria F NUDIX domain nudJ - - - - - - - - - - - NUDIX k59_1367751_1 1167006.UWK_00922 4.31e-40 147.0 295V5@1|root,2ZT65@2|Bacteria,1REG0@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1314996_1 1469245.JFBG01000052_gene2167 1.02e-140 405.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,1RMK8@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Branched-chain amino acid transport - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_1314996_2 1469245.JFBG01000052_gene2168 3.03e-129 372.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,1RQU2@1236|Gammaproteobacteria,1X2CD@135613|Chromatiales 135613|Chromatiales E Branched-chain amino acid ATP-binding cassette transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_1314996_3 331869.BAL199_12931 1.83e-90 275.0 COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,2TVFT@28211|Alphaproteobacteria,4BRDF@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Branched-chain amino acid transport system permease - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1416712_2 335543.Sfum_0758 1.8e-96 315.0 COG4775@1|root,COG4775@2|Bacteria,1QX52@1224|Proteobacteria,43CEZ@68525|delta/epsilon subdivisions,2X7PY@28221|Deltaproteobacteria,2MRBQ@213462|Syntrophobacterales 28221|Deltaproteobacteria M Surface antigen - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_320314_1 1184267.A11Q_2373 2.97e-13 72.8 COG4962@1|root,COG4963@1|root,COG4962@2|Bacteria,COG4963@2|Bacteria,1R7EN@1224|Proteobacteria,42NAK@68525|delta/epsilon subdivisions,2MSSH@213481|Bdellovibrionales,2WIYX@28221|Deltaproteobacteria 213481|Bdellovibrionales U PFAM Type II secretion system protein E - - - ko:K02283,ko:K03609 - - - - ko00000,ko02035,ko02044,ko03036,ko04812 - - - CbiA,FHA,T2SSE k59_1573038_2 1194972.MVAC_27874 1.35e-16 83.6 2DB85@1|root,2Z7Q2@2|Bacteria,2GTBY@201174|Actinobacteria,2332E@1762|Mycobacteriaceae 201174|Actinobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_686957_1 1004785.AMBLS11_17420 1.83e-119 380.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464AK@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1051303_1 953739.SVEN_2995 2.19e-27 112.0 COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria 201174|Actinobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase k59_1051303_2 366394.Smed_2619 6.27e-22 94.4 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2TSHT@28211|Alphaproteobacteria,4B9ZM@82115|Rhizobiaceae 28211|Alphaproteobacteria EH Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_372012_1 1123401.JHYQ01000009_gene2254 2.26e-63 203.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,462D8@72273|Thiotrichales 72273|Thiotrichales KT LytTr DNA-binding domain - - - ko:K08083 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_1261646_1 880072.Desac_2644 3.5e-28 119.0 COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria,2MQTZ@213462|Syntrophobacterales 28221|Deltaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom k59_528555_1 1049564.TevJSym_ac01310 2.33e-86 268.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1J5IR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_791420_1 1123518.ARWI01000001_gene1948 1.55e-100 308.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,4601B@72273|Thiotrichales 72273|Thiotrichales EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_372018_1 195250.CM001776_gene3267 2.63e-42 150.0 COG0309@1|root,COG0309@2|Bacteria,1G1Z7@1117|Cyanobacteria,1GZCQ@1129|Synechococcus 1117|Cyanobacteria O Hydrogenase expression formation protein HypE hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_1364566_1 1198232.CYCME_0769 1.65e-62 196.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,4601G@72273|Thiotrichales 72273|Thiotrichales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_320335_1 76114.ebA6923 4.69e-95 301.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria,2KVM1@206389|Rhodocyclales 206389|Rhodocyclales G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.196,3.2.1.68 ko:K01214,ko:K02438 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_1416735_1 756067.MicvaDRAFT_0281 2.21e-17 85.1 COG3608@1|root,COG3608@2|Bacteria,1G38S@1117|Cyanobacteria 1117|Cyanobacteria S Protein of unknown function (DUF2817) - - - - - - - - - - - - DUF2817 k59_110372_1 871585.BDGL_000161 1.15e-179 508.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,3NJ7T@468|Moraxellaceae 1236|Gammaproteobacteria NU twitching motility protein pilT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_110372_2 95619.PM1_0226615 1.02e-90 277.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU twitching motility protein pilU - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_476409_1 926550.CLDAP_07150 8.03e-88 278.0 COG4263@1|root,COG4263@2|Bacteria,2G8B2@200795|Chloroflexi 200795|Chloroflexi C nitrous-oxide reductase activity - - 1.7.2.4 ko:K00376 ko00910,ko01120,map00910,map01120 M00529 R02804 RC02861 ko00000,ko00001,ko00002,ko01000 - - - - k59_1364570_2 545276.KB898724_gene2124 5.11e-81 255.0 COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,1RMV8@1236|Gammaproteobacteria,1WZG8@135613|Chromatiales 135613|Chromatiales P PFAM periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_528573_1 1260251.SPISAL_07690 5.09e-58 200.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1WW2F@135613|Chromatiales 135613|Chromatiales P Chloride channel - - - - - - - - - - - - Voltage_CLC k59_320343_1 1122135.KB893135_gene982 4.71e-16 77.8 COG3528@1|root,COG3528@2|Bacteria,1R601@1224|Proteobacteria,2U1IH@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - DUF2219 k59_998484_1 1415778.JQMM01000001_gene1214 3.49e-67 215.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,1J4MT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB GO:0000287,GO:0003674,GO:0003824,GO:0004349,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019202,GO:0019752,GO:0031406,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0055129,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901973 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_998484_2 626887.J057_14570 7.97e-09 57.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,4647H@72275|Alteromonadaceae 1236|Gammaproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0043021,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0065003,GO:0065007,GO:0070925,GO:0071826,GO:0071840,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_1573074_1 933262.AXAM01000027_gene2113 2.7e-32 127.0 COG1716@1|root,COG2304@1|root,COG1716@2|Bacteria,COG2304@2|Bacteria 2|Bacteria IU oxidoreductase activity - - - ko:K08777 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002 - - - FHA,VWA k59_687001_1 765911.Thivi_3234 5.61e-47 160.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1WW98@135613|Chromatiales 135613|Chromatiales Q PFAM ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_424335_1 62928.azo0148 1.37e-118 360.0 COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,2VJ4I@28216|Betaproteobacteria,2KV3W@206389|Rhodocyclales 206389|Rhodocyclales I Transmembrane secretion effector - - - - - - - - - - - - Acyltransferase,MFS_1 k59_424335_2 1009370.ALO_07428 3.34e-24 98.6 COG0662@1|root,COG0662@2|Bacteria,1UKG0@1239|Firmicutes,4H9CE@909932|Negativicutes 909932|Negativicutes G Cupin 2, conserved barrel - - - - - - - - - - - - Cupin_2 k59_424335_3 134676.ACPL_4263 9.89e-05 47.8 COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4DJJA@85008|Micromonosporales 201174|Actinobacteria C Threonine dehydrogenase and related Zn-dependent dehydrogenases tdh - 1.1.1.103,1.1.1.14,1.1.1.380 ko:K00008,ko:K00060,ko:K08322 ko00040,ko00051,ko00260,ko01100,map00040,map00051,map00260,map01100 M00014 R00875,R01465,R01896,R10848 RC00085,RC00102,RC00525 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N k59_580961_1 420324.KI911984_gene5121 1.54e-41 147.0 COG3547@1|root,COG3547@2|Bacteria,1QYJU@1224|Proteobacteria,2U1TU@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1155577_1 557598.LHK_01906 3.47e-41 149.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KPJ5@206351|Neisseriales 206351|Neisseriales T Sigma-54 interaction domain protein glnG - - ko:K07712,ko:K07714 ko02020,map02020 M00497,M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1155577_2 582744.Msip34_2494 3.36e-52 176.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2VJN7@28216|Betaproteobacteria,2KKW6@206350|Nitrosomonadales 206350|Nitrosomonadales T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_1364583_1 1184609.KILIM_007_00680 6.01e-08 53.5 2C8CT@1|root,32WE6@2|Bacteria,2IKPA@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - DUF1863,TIR_2 k59_1364583_2 1121438.JNJA01000002_gene3841 4.24e-29 107.0 COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42V9Q@68525|delta/epsilon subdivisions,2WRRT@28221|Deltaproteobacteria,2MCID@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM RNP-1 like RNA-binding protein - - - - - - - - - - - - RRM_1 k59_1364583_3 202956.BBNL01000016_gene562 1.39e-14 71.6 2E3RU@1|root,32YPG@2|Bacteria,1NAWV@1224|Proteobacteria,1SDMM@1236|Gammaproteobacteria,3NPMF@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1312166_1 1089552.KI911559_gene1655 2.21e-82 271.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JRMJ@204441|Rhodospirillales 204441|Rhodospirillales V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_1051349_1 1121918.ARWE01000001_gene3120 6.47e-177 511.0 COG3946@1|root,COG3946@2|Bacteria,1R7R5@1224|Proteobacteria,42SDF@68525|delta/epsilon subdivisions,2WP3V@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Bacterial virulence protein (VirJ) - - - - - - - - - - - - VirJ k59_215281_1 1089547.KB913013_gene4193 0.00031 45.4 COG2374@1|root,COG5276@1|root,COG2374@2|Bacteria,COG5276@2|Bacteria 2|Bacteria - - nucH - 3.1.3.5 ko:K01081,ko:K07004 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Calx-beta,Exo_endo_phos,He_PIG,LTD,Metallophos k59_1209630_1 1232410.KI421413_gene670 1.78e-22 91.3 COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,42V1F@68525|delta/epsilon subdivisions,2WR79@28221|Deltaproteobacteria,43SR6@69541|Desulfuromonadales 28221|Deltaproteobacteria K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 k59_1625686_1 331869.BAL199_12741 2e-63 209.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2TQT3@28211|Alphaproteobacteria,4BPP1@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_1573092_1 443143.GM18_3973 5.12e-09 58.9 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,43SX3@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_1573092_2 667014.Thein_1415 4.33e-16 78.6 COG0755@1|root,COG0755@2|Bacteria,2GGYG@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria O Cytochrome C assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_1416772_1 530564.Psta_1375 8.66e-49 163.0 COG0279@1|root,COG0279@2|Bacteria,2IZ19@203682|Planctomycetes 203682|Planctomycetes G Phosphoheptose isomerase - - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 k59_1416772_2 479431.Namu_2253 7.38e-72 236.0 COG1482@1|root,COG1482@2|Bacteria,2GJXC@201174|Actinobacteria,4ERG9@85013|Frankiales 201174|Actinobacteria G PFAM mannose-6-phosphate isomerase type I manA - 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 - - - PMI_typeI k59_894704_1 56110.Oscil6304_3012 9.27e-54 178.0 COG0546@1|root,COG0546@2|Bacteria,1G52P@1117|Cyanobacteria,1HB0I@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Haloacid dehalogenase-like hydrolase cbbZp - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_1469855_1 96561.Dole_0481 2.51e-14 77.4 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,42NJ0@68525|delta/epsilon subdivisions,2WJ7A@28221|Deltaproteobacteria,2MIEV@213118|Desulfobacterales 28221|Deltaproteobacteria M SMART PDZ DHR GLGF domain protein rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_998518_1 314254.OA2633_14666 9.39e-12 62.4 COG1320@1|root,COG1320@2|Bacteria,1N75I@1224|Proteobacteria,2UETR@28211|Alphaproteobacteria,43Y5P@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Na+/H+ antiporter subunit - - - ko:K05571 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - PhaG_MnhG_YufB k59_998518_2 1247963.JPHU01000005_gene352 1.79e-32 115.0 COG2212@1|root,COG2212@2|Bacteria,1N6VV@1224|Proteobacteria,2UHB7@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Multiple resistance and pH regulation protein F - - - ko:K05570 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MrpF_PhaF k59_998518_3 1415778.JQMM01000001_gene1293 2.12e-13 67.0 COG1863@1|root,COG1863@2|Bacteria,1MZYJ@1224|Proteobacteria,1S7Z3@1236|Gammaproteobacteria,1J63V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Na+/H+ ion antiporter subunit mnhE - - ko:K05569 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MNHE k59_946197_1 1150469.RSPPHO_02649 2.86e-27 108.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,2JPG4@204441|Rhodospirillales 204441|Rhodospirillales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_268516_3 1030157.AFMP01000016_gene2417 1.34e-39 141.0 COG5361@1|root,COG5361@2|Bacteria,1NR2J@1224|Proteobacteria,2UPPV@28211|Alphaproteobacteria,2K216@204457|Sphingomonadales 204457|Sphingomonadales S Conserved Protein - - - - - - - - - - - - - k59_1365247_2 1125863.JAFN01000001_gene1832 5.89e-106 323.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,42MBH@68525|delta/epsilon subdivisions,2WJQV@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM aminotransferase class V - - - - - - - - - - - - Aminotran_5 k59_529234_1 1158292.JPOE01000002_gene2435 0.000194 44.3 COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,2VH34@28216|Betaproteobacteria 28216|Betaproteobacteria EH Thiamine pyrophosphate-requiring enzymes acetolactate synthase pyruvate dehydrogenase (cytochrome) glyoxylate carboligase phosphonopyruvate decarboxylase ilvX - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_N k59_529234_2 195250.CM001776_gene1592 3.29e-44 149.0 2CEUC@1|root,32S0I@2|Bacteria,1G7VG@1117|Cyanobacteria,1H398@1129|Synechococcus 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_529234_3 631362.Thi970DRAFT_04874 9.09e-22 88.2 COG0662@1|root,COG0662@2|Bacteria,1RFTK@1224|Proteobacteria,1S5QK@1236|Gammaproteobacteria,1WYE9@135613|Chromatiales 135613|Chromatiales G PFAM Cupin - - - - - - - - - - - - Cupin_2 k59_792458_1 1144275.COCOR_06731 2.12e-47 167.0 COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 k59_110985_1 768671.ThimaDRAFT_0873 6.52e-82 265.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGB@1236|Gammaproteobacteria,1X1MI@135613|Chromatiales 135613|Chromatiales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_1470714_1 224325.AF_0988 1.17e-14 73.9 COG2358@1|root,arCOG01802@2157|Archaea 2157|Archaea E TRAP transporter solute receptor, TAXI family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_1470714_2 1469245.JFBG01000062_gene2271 6.93e-24 102.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S TRAP transporter, 4TM 12TM fusion protein - - - - - - - - - - - - DctM k59_635835_1 1009370.ALO_04983 4.96e-15 78.6 COG0834@1|root,COG0834@2|Bacteria,1TQUG@1239|Firmicutes,4H1US@909932|Negativicutes 909932|Negativicutes ET Belongs to the bacterial solute-binding protein 3 family glnH - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_61311_1 399795.CtesDRAFT_PD0398 1.48e-74 241.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,4AAVU@80864|Comamonadaceae 28216|Betaproteobacteria V ABC transporter, transmembrane region atm1 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_425142_1 204773.HEAR1468 3.05e-47 166.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VJME@28216|Betaproteobacteria,473G9@75682|Oxalobacteraceae 28216|Betaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_1365262_1 646529.Desaci_1877 5.98e-97 305.0 COG2185@1|root,COG2185@2|Bacteria,1UJHA@1239|Firmicutes,25F35@186801|Clostridia 186801|Clostridia I D-Lysine 5,6-aminomutase alpha subunit - - 5.4.3.5 ko:K17898 ko00472,map00472 - R02461 RC00719 ko00000,ko00001,ko01000 - - - B12-binding,Lys-AminoMut_A,OAM_dimer k59_321236_1 696747.NIES39_A04370 1.08e-74 240.0 COG0306@1|root,COG0306@2|Bacteria 2|Bacteria P phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_1417447_1 1380355.JNIJ01000022_gene3590 1.91e-117 350.0 COG5016@1|root,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,2TT4W@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Conserved carboxylase domain - - 4.1.1.3 ko:K01571 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - HMGL-like,PYC_OADA k59_1365267_1 1123499.KB908033_gene368 5.34e-42 157.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,2KQD0@206351|Neisseriales 206351|Neisseriales I Phospholipase D. Active site motifs. - - - - - - - - - - - - PLDc_2 k59_1156211_1 1469245.JFBG01000076_gene136 5.15e-34 120.0 COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria 1236|Gammaproteobacteria C A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters nifU - - ko:K04488 - - - - ko00000 - - - NifU_N k59_1156211_2 314278.NB231_04905 2.19e-70 225.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1WWTN@135613|Chromatiales 135613|Chromatiales E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5,SufE k59_687923_1 321332.CYB_1689 1e-77 252.0 COG1132@1|root,COG1132@2|Bacteria,1G0UP@1117|Cyanobacteria,1GZ34@1129|Synechococcus 1117|Cyanobacteria V ABC-type multidrug transport system, ATPase and permease - - - ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_635851_1 1283299.AUKG01000002_gene4080 2.48e-06 50.1 COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4CR1R@84995|Rubrobacteria 84995|Rubrobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_635851_2 297246.lpp0758 2.53e-47 167.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1JC6T@118969|Legionellales 118969|Legionellales S ABC transporter yjjK - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_581596_1 1279009.ADICEAN_03294 4.65e-34 128.0 COG1533@1|root,COG1533@2|Bacteria,4NIY5@976|Bacteroidetes,47KVR@768503|Cytophagia 976|Bacteroidetes L DNA photolyase activity - - - - - - - - - - - - - k59_1104412_1 1131266.ARWQ01000004_gene1443 1.14e-35 127.0 COG0494@1|root,arCOG01072@2157|Archaea,41STX@651137|Thaumarchaeota 651137|Thaumarchaeota L NUDIX domain - - - - - - - - - - - - NUDIX k59_1104412_2 1229909.NSED_07095 8.21e-06 46.6 COG0685@1|root,arCOG00475@2157|Archaea,41SNK@651137|Thaumarchaeota 651137|Thaumarchaeota E cytochrome-c peroxidase activity - - - - - - - - - - - - - k59_110991_1 1335757.SPICUR_02565 3.45e-101 298.0 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1WW35@135613|Chromatiales 135613|Chromatiales L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_110991_2 1304883.KI912532_gene3037 1.82e-21 94.7 COG4398@1|root,COG4398@2|Bacteria,1RBRR@1224|Proteobacteria,2VQ7K@28216|Betaproteobacteria,2KWHA@206389|Rhodocyclales 206389|Rhodocyclales S FIST_C - - - - - - - - - - - - FIST_C k59_1052101_1 1211114.ALIP01000098_gene1827 6.91e-11 66.6 COG3137@1|root,COG3137@2|Bacteria,1MWI4@1224|Proteobacteria,1RN4J@1236|Gammaproteobacteria,1X57Z@135614|Xanthomonadales 135614|Xanthomonadales M salt-induced outer membrane protein - - - ko:K07283 - - - - ko00000 - - - DUF481 k59_1052101_2 426355.Mrad2831_1722 2.41e-16 76.6 COG1028@1|root,COG1028@2|Bacteria,1MWJI@1224|Proteobacteria,2TRNJ@28211|Alphaproteobacteria,1JTKS@119045|Methylobacteriaceae 28211|Alphaproteobacteria IQ PFAM short-chain dehydrogenase reductase SDR MA20_19195 - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_161790_3 203119.Cthe_2457 1.64e-22 88.2 2EC8I@1|root,33670@2|Bacteria,1VNEP@1239|Firmicutes,25DQM@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_693013_1 75379.Tint_1277 2.78e-56 183.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2VHHB@28216|Betaproteobacteria,1KKQG@119065|unclassified Burkholderiales 28216|Betaproteobacteria KT Transcriptional regulatory protein, C terminal - - - ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_221108_1 1158292.JPOE01000002_gene1721 8.84e-13 65.5 COG3193@1|root,COG3193@2|Bacteria,1REF5@1224|Proteobacteria,2VT55@28216|Betaproteobacteria,1KMI7@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Haem-degrading - - - - - - - - - - - - Haem_degrading k59_221108_2 1500304.JQKY01000008_gene3092 4.69e-37 143.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,TPR_16,TPR_19,TPR_2,TPR_8 k59_586682_1 478741.JAFS01000002_gene697 9.64e-22 90.5 COG0838@1|root,COG0838@2|Bacteria,46T33@74201|Verrucomicrobia,37GQG@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_847869_1 436308.Nmar_1251 7.19e-78 235.0 arCOG04006@1|root,arCOG04006@2157|Archaea,41SKF@651137|Thaumarchaeota 651137|Thaumarchaeota C PBS lyase HEAT-like repeat - - 1.14.99.29 ko:K06072 - - - - ko00000,ko01000 - - - HEAT_2 k59_743206_1 395493.BegalDRAFT_1999 2.4e-47 162.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,460BA@72273|Thiotrichales 72273|Thiotrichales I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_743206_2 187272.Mlg_1423 2.18e-18 83.2 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1WWWT@135613|Chromatiales 135613|Chromatiales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_1423462_1 1323663.AROI01000015_gene548 1.99e-61 201.0 COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,1RQHG@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Integrase catalytic - - - - - - - - - - - - HTH_23,LZ_Tnp_IS481,rve k59_221118_1 196367.JNFG01000028_gene8372 1.35e-11 70.1 COG3156@1|root,COG3156@2|Bacteria,1RBNV@1224|Proteobacteria,2VS9P@28216|Betaproteobacteria,1K1E0@119060|Burkholderiaceae 28216|Betaproteobacteria U general secretion pathway protein K gspK - - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_1477004_1 1380355.JNIJ01000022_gene3589 6.91e-144 412.0 COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,2TRG7@28211|Alphaproteobacteria,3JS2V@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S beta-keto acid cleavage enzyme - - 2.3.1.247 ko:K18013 ko00310,map00310 - R10564 RC02728,RC03199 ko00000,ko00001,ko01000 - - - BKACE k59_534244_1 1121289.JHVL01000031_gene350 0.00056 43.9 COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,36DQW@31979|Clostridiaceae 186801|Clostridia J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1216084_1 686340.Metal_0455 7.6e-16 72.0 COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,1S8XZ@1236|Gammaproteobacteria,1XFCN@135618|Methylococcales 135618|Methylococcales K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control himD - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_1216084_2 396588.Tgr7_1546 1.36e-44 156.0 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,1WWKI@135613|Chromatiales 135613|Chromatiales G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB - - ko:K19804 - - - - ko00000 - - - TPR_16,TPR_7 k59_67665_1 444860.E3SJ63_9CAUD 1.78e-58 199.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QI6A@10662|Myoviridae 10662|Myoviridae S Ribonucleotide reductase, barrel domain - - - - - - - - - - - - - k59_67665_2 444860.E3SJ62_9CAUD 5.37e-182 512.0 4QF76@10239|Viruses,4QZE5@35237|dsDNA viruses no RNA stage,4QQDU@28883|Caudovirales,4QJUE@10662|Myoviridae 10662|Myoviridae S DNA primase activity - - - - - - - - - - - - - k59_642307_1 1125863.JAFN01000001_gene2043 5.8e-19 87.8 COG2981@1|root,COG2981@2|Bacteria,1MVFT@1224|Proteobacteria,42RW8@68525|delta/epsilon subdivisions,2WNP6@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Etoposide-induced protein 2.4 (EI24) - - - ko:K06203 - - - - ko00000 - - - EI24 k59_1268996_1 99598.Cal7507_4321 9.65e-100 301.0 COG1600@1|root,COG3255@1|root,COG1600@2|Bacteria,COG3255@2|Bacteria,1G07Y@1117|Cyanobacteria 1117|Cyanobacteria CI PFAM 4Fe-4S binding domain - - - - - - - - - - - - Dehalogenase,Fer4,Fer4_7,SCP2 k59_1004253_1 59538.XP_005968341.1 2.7e-69 226.0 COG0148@1|root,KOG2670@2759|Eukaryota,38C66@33154|Opisthokonta,3BE2S@33208|Metazoa,3CU4G@33213|Bilateria,480BN@7711|Chordata,48V1P@7742|Vertebrata,3J8GJ@40674|Mammalia,4IXIP@91561|Cetartiodactyla 33208|Metazoa G enolase 2 enol-1 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_1109343_1 1496688.ER33_15360 2.63e-105 318.0 COG2308@1|root,COG2308@2|Bacteria 2|Bacteria S glutamate-cysteine ligase activity - - - - - - - - - - - - - k59_900383_1 517417.Cpar_1281 3.69e-52 184.0 COG1331@1|root,COG1331@2|Bacteria,1FDQN@1090|Chlorobi 1090|Chlorobi O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_5525_1 666685.R2APBS1_3860 5.03e-61 197.0 COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,1RMUT@1236|Gammaproteobacteria,1X3K2@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE GO:0003674,GO:0003824,GO:0004766,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth k59_743248_1 1196323.ALKF01000205_gene4124 5.62e-22 99.0 COG1785@1|root,COG1785@2|Bacteria,1TQCI@1239|Firmicutes,4HA27@91061|Bacilli,26S8G@186822|Paenibacillaceae 91061|Bacilli P Belongs to the alkaline phosphatase family phoA - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase,Cu_amine_oxidN1 k59_799308_1 1249997.JHZW01000002_gene1016 2.43e-35 128.0 COG1285@1|root,COG1285@2|Bacteria,4NTPJ@976|Bacteroidetes,1I8N8@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4956) - - - - - - - - - - - - DUF4956 k59_643913_1 1211114.ALIP01000111_gene1263 1.22e-13 72.4 COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,1S4HV@1236|Gammaproteobacteria,1XC60@135614|Xanthomonadales 135614|Xanthomonadales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_69272_1 243231.GSU1456 5.84e-39 150.0 COG0457@1|root,COG0457@2|Bacteria,1NU49@1224|Proteobacteria,42YQH@68525|delta/epsilon subdivisions,2WU55@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TPR repeat - - - - - - - - - - - - - k59_952913_1 1169152.AXVD01000007_gene1828 3.85e-100 299.0 COG2230@1|root,COG2230@2|Bacteria 2|Bacteria M cyclopropane-fatty-acyl-phospholipid synthase - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0032259,GO:0044237,GO:0044249 2.1.1.254,2.1.1.295,2.1.1.79,2.7.11.1 ko:K00574,ko:K07154,ko:K14369,ko:K15257,ko:K18534 ko00130,ko00522,ko01100,ko01110,ko01130,map00130,map00522,map01100,map01110,map01130 M00112,M00774 R05520,R05532,R07501,R10709,R10710 RC00003,RC01324,RC01662 ko00000,ko00001,ko00002,ko01000,ko01001,ko01008,ko02048,ko03016 - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_1216895_1 1054213.HMPREF9946_03253 4.9e-78 241.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,2JS0P@204441|Rhodospirillales 204441|Rhodospirillales Q Dienelactone hydrolase family - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_800936_1 5759.rna_EHI_183180-1 1.16e-11 67.8 COG0450@1|root,KOG0852@2759|Eukaryota,3XBDH@554915|Amoebozoa 554915|Amoebozoa O AhpC/TSA family - - - - - - - - - - - - AhpC-TSA k59_800936_2 756272.Plabr_4515 1.8e-42 144.0 COG0605@1|root,COG0605@2|Bacteria,2IX16@203682|Planctomycetes 203682|Planctomycetes C Destroys radicals which are normally produced within the cells and which are toxic to biological systems - - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_379575_1 857087.Metme_0583 2.07e-44 150.0 2CKY4@1|root,33K9I@2|Bacteria,1R395@1224|Proteobacteria,1T652@1236|Gammaproteobacteria,1XF7F@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - k59_379575_2 1203605.HMPREF1531_01319 2.78e-21 100.0 COG1477@1|root,COG1477@2|Bacteria 2|Bacteria H protein flavinylation apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_379575_3 1177154.Y5S_01004 7.61e-55 191.0 COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,1S1Y5@1236|Gammaproteobacteria 1236|Gammaproteobacteria F P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_1632817_1 330214.NIDE3184 2.71e-88 273.0 COG0513@1|root,COG0513@2|Bacteria 2|Bacteria L helicase activity rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_535328_1 1265502.KB905937_gene2611 1.37e-23 99.8 COG0457@1|root,COG4976@1|root,COG0457@2|Bacteria,COG4976@2|Bacteria,1RAIT@1224|Proteobacteria,2WEY2@28216|Betaproteobacteria,4AJ0V@80864|Comamonadaceae 28216|Betaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - Methyltransf_25,TPR_1,TPR_16,TPR_2,TPR_8 k59_1425074_1 1206743.BAGM01000207_gene199 3.33e-18 84.3 COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4FY7P@85025|Nocardiaceae 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1425074_2 1157640.AQWO01000017_gene3437 7.49e-16 77.8 COG2159@1|root,COG2159@2|Bacteria,2GP2D@201174|Actinobacteria 201174|Actinobacteria S amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_167852_1 330214.NIDE1227 4.57e-117 354.0 COG0642@1|root,COG0784@1|root,COG0642@2|Bacteria,COG0784@2|Bacteria 2|Bacteria T Response regulator, receiver - - 2.7.13.3 ko:K20973 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_3 k59_535329_1 1121935.AQXX01000124_gene105 8.58e-51 177.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1XH2W@135619|Oceanospirillales 135619|Oceanospirillales C Cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_430867_1 335543.Sfum_3763 4.07e-185 523.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria 1224|Proteobacteria L COG3335 Transposase and inactivated derivatives - - - ko:K07494 - - - - ko00000 - - - DDE_3,HTH_23,HTH_32,HTH_33 k59_69289_1 765914.ThisiDRAFT_1351 2.27e-20 88.2 COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,1SAMR@1236|Gammaproteobacteria,1WZS4@135613|Chromatiales 135613|Chromatiales S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_6 k59_69289_2 1236541.BALL01000050_gene4249 2.33e-32 118.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,2Q8RY@267890|Shewanellaceae 1236|Gammaproteobacteria K transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - - - - - - - - - - Transcrip_reg k59_744246_1 663278.Ethha_1138 4.03e-17 87.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,3WGKX@541000|Ruminococcaceae 186801|Clostridia L ATP-dependent DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_274459_1 1111121.HMPREF1247_1613 4.71e-32 129.0 COG1243@1|root,COG1243@2|Bacteria,2HUHE@201174|Actinobacteria,4CUN9@84998|Coriobacteriia 84998|Coriobacteriia BK histone acetyltransferase, ELP3 family - - 2.3.1.48 ko:K07739 - - - - ko00000,ko01000,ko03016,ko03036 - - - Acetyltransf_1,Acetyltransf_10,Radical_SAM,Radical_SAM_C k59_274459_2 290397.Adeh_0385 0.000777 42.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2YUBF@29|Myxococcales 28221|Deltaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1216909_1 338963.Pcar_3003 3.94e-41 155.0 COG1538@1|root,COG1538@2|Bacteria,1MYXE@1224|Proteobacteria,42TA7@68525|delta/epsilon subdivisions,2WR7T@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1270670_1 246196.MSMEI_0873 3.81e-11 63.2 COG4091@1|root,COG4091@2|Bacteria,2I8GM@201174|Actinobacteria,23A2E@1762|Mycobacteriaceae 201174|Actinobacteria E SAF - - - - - - - - - - - - GFO_IDH_MocA,NAD_binding_3,SAF k59_1005290_1 1333998.M2A_2787 4.5e-80 248.0 COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2TRXY@28211|Alphaproteobacteria,4BSZR@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Amidohydrolase MA20_19310 - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_1425110_2 864051.BurJ1DRAFT_3134 2.71e-30 120.0 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2VM6E@28216|Betaproteobacteria,1KMK7@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Transglycosylase SLT domain - - - - - - - - - - - - SLT,Sel1 k59_848932_1 400682.PAC_15704303 1.47e-154 452.0 COG0069@1|root,KOG0399@2759|Eukaryota,38E4E@33154|Opisthokonta,3BECM@33208|Metazoa 33208|Metazoa E glutamate synthase (NADH) activity. It is involved in the biological process described with oxidation-reduction process - - - - - - - - - - - - Fer4_20,GATase_2,Glu_syn_central,Glu_synthase,Pyr_redox_2 k59_744265_1 977880.RALTA_A0971 8.19e-61 202.0 COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2VI8J@28216|Betaproteobacteria,1K4EB@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM FAD linked oxidase domain protein - - - - - - - - - - - - BBE,FAD_binding_4 k59_1058128_1 1192034.CAP_4624 1.02e-57 189.0 COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,42PVS@68525|delta/epsilon subdivisions,2WJ7B@28221|Deltaproteobacteria,2YXQQ@29|Myxococcales 28221|Deltaproteobacteria E Glucose dehydrogenase C-terminus - - - - - - - - - - - - ADH_N,ADH_zinc_N,Glu_dehyd_C k59_1058128_2 58123.JOFJ01000008_gene498 2.52e-38 141.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4ENGU@85012|Streptosporangiales 201174|Actinobacteria Q Cytochrome P450 - - 1.14.13.221 ko:K16046 ko00984,ko01120,map00984,map01120 - R09859,R11361 RC01216,RC03368 ko00000,ko00001,ko00199,ko01000 - - - p450 k59_800997_1 1123024.AUII01000035_gene1220 1.24e-113 354.0 COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4DZUH@85010|Pseudonocardiales 201174|Actinobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1632855_1 396588.Tgr7_0263 1.33e-136 403.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales 135613|Chromatiales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_117448_1 420324.KI911947_gene5526 5.82e-90 277.0 COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,2TSR9@28211|Alphaproteobacteria,1JT3W@119045|Methylobacteriaceae 28211|Alphaproteobacteria E PFAM Ornithine cyclodeaminase mu-crystallin - - 4.3.1.12 ko:K01750 ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230 - R00671 RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall k59_222276_2 90814.KL370891_gene1206 7.44e-14 70.5 2CEDU@1|root,333S9@2|Bacteria,1NI7T@1224|Proteobacteria,1T0VC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4156) - - - - - - - - - - - - DUF4156 k59_1579785_1 1229909.NSED_00115 4.65e-59 191.0 COG0702@1|root,arCOG03015@2157|Archaea,41T19@651137|Thaumarchaeota 651137|Thaumarchaeota M NAD(P)H-binding - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - NAD_binding_10 k59_1058139_1 1121918.ARWE01000001_gene404 9.14e-119 353.0 COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,42MG7@68525|delta/epsilon subdivisions,2WIRA@28221|Deltaproteobacteria 28221|Deltaproteobacteria CP PFAM NADH Ubiquinone plastoquinone (complex I) - - - ko:K12141 - - - - ko00000,ko01000 - - - Proton_antipo_M k59_1161364_1 400682.PAC_15705790 1.33e-110 343.0 COG0843@1|root,COG1622@1|root,KOG4767@2759|Eukaryota,KOG4769@2759|Eukaryota,38JQ7@33154|Opisthokonta,3BGCX@33208|Metazoa 33208|Metazoa C electron transport coupled proton transport - - - - - - - - - - - - COX1,COX2 k59_644000_1 745310.G432_15570 6.84e-53 183.0 COG2365@1|root,COG2365@2|Bacteria,1R4XF@1224|Proteobacteria,2U0KA@28211|Alphaproteobacteria,2K2AD@204457|Sphingomonadales 204457|Sphingomonadales T Tyrosine phosphatase family - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - Y_phosphatase3 k59_485177_1 479434.Sthe_3238 1.05e-50 167.0 COG0717@1|root,COG0717@2|Bacteria,2GBA2@200795|Chloroflexi,27Y8U@189775|Thermomicrobia 189775|Thermomicrobia F dUTPase - - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase k59_379679_1 1120985.AUMI01000014_gene1061 4.87e-11 63.9 COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,4H6HB@909932|Negativicutes 909932|Negativicutes T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - GGDEF,HD_5,PAS_9 k59_379679_2 349124.Hhal_2014 3.14e-15 78.2 COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,1S03J@1236|Gammaproteobacteria,1WXFJ@135613|Chromatiales 135613|Chromatiales S PFAM Major Facilitator Superfamily - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_587756_1 762376.AXYL_04793 2.41e-29 118.0 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2VJBJ@28216|Betaproteobacteria,3T8PK@506|Alcaligenaceae 28216|Betaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1161372_1 243233.MCA2171 1e-68 238.0 2ECB1@1|root,3369C@2|Bacteria,1NX58@1224|Proteobacteria,1SRD4@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1161372_2 525897.Dbac_1094 0.000957 45.4 COG1234@1|root,COG1234@2|Bacteria,1PE64@1224|Proteobacteria,42RZR@68525|delta/epsilon subdivisions 1224|Proteobacteria S beta-lactamase domain protein - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_379716_2 404589.Anae109_4146 2.14e-74 235.0 COG0451@1|root,COG0451@2|Bacteria,1N8PG@1224|Proteobacteria,42TCH@68525|delta/epsilon subdivisions,2WPEI@28221|Deltaproteobacteria,2YU8R@29|Myxococcales 28221|Deltaproteobacteria GM GDP-mannose 4,6 dehydratase - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_1371389_1 391735.Veis_4744 6.53e-103 307.0 COG4336@1|root,COG4336@2|Bacteria,1MW52@1224|Proteobacteria,2VJUJ@28216|Betaproteobacteria,4AA6P@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the D-glutamate cyclase family - - - - - - - - - - - - DUF1445 k59_117514_1 330779.Saci_2283 4.71e-19 86.3 arCOG01129@1|root,arCOG01129@2157|Archaea,2XS33@28889|Crenarchaeota 28889|Crenarchaeota K PFAM TENA THI-4 domain protein - - - - - - - - - - - - TENA_THI-4 k59_1005354_1 671143.DAMO_1127 4.99e-18 83.2 COG0510@1|root,COG0510@2|Bacteria 2|Bacteria M ethanolamine kinase activity - - 2.7.1.89 ko:K07251 ko00730,ko01100,map00730,map01100 - R02134 RC00002,RC00017 ko00000,ko00001,ko01000 - - - APH,Choline_kinase,EcKinase k59_1005354_2 983545.Glaag_2259 5.06e-67 221.0 COG1757@1|root,COG1757@2|Bacteria,1MVDF@1224|Proteobacteria,1RS40@1236|Gammaproteobacteria,464WZ@72275|Alteromonadaceae 1236|Gammaproteobacteria C Na H antiporter nhaC - - ko:K03315 - - - - ko00000,ko02000 2.A.35 - - Na_H_antiporter k59_327303_1 1123073.KB899241_gene2348 8.26e-35 126.0 COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,1RXUZ@1236|Gammaproteobacteria,1X60Y@135614|Xanthomonadales 135614|Xanthomonadales F Glutamine amidotransferase class-I - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase k59_644052_1 926550.CLDAP_22280 1.9e-34 125.0 COG3019@1|root,COG3019@2|Bacteria 2|Bacteria S metal-binding protein copG - - - - - - - - - - - DUF411 k59_1523721_1 247490.KSU1_C1308 4.48e-61 200.0 COG3385@1|root,COG3385@2|Bacteria,2IZDT@203682|Planctomycetes 203682|Planctomycetes L Transposase IS4 family - - - - - - - - - - - - DDE_Tnp_1 k59_809948_3 105559.Nwat_0686 8.43e-82 256.0 COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,1WXIP@135613|Chromatiales 135613|Chromatiales E Belongs to the agmatine deiminase family aguA - - - - - - - - - - - PAD_porph k59_1487550_1 1382304.JNIL01000001_gene2317 3.86e-67 220.0 COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,4H9X6@91061|Bacilli,277XG@186823|Alicyclobacillaceae 91061|Bacilli F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_1117070_1 667632.KB890179_gene106 5.62e-26 108.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,1K37E@119060|Burkholderiaceae 28216|Betaproteobacteria C oxidoreductase porG - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_1225305_2 266117.Rxyl_0146 5.25e-39 145.0 COG0243@1|root,COG0243@2|Bacteria,2GJWZ@201174|Actinobacteria,4CQ1R@84995|Rubrobacteria 84995|Rubrobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdopterin,Molydop_binding k59_1434777_1 1286093.C266_06434 2.3e-37 136.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,1K4KX@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_38,rve k59_1587465_1 420324.KI912061_gene6197 3.12e-64 221.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,1JR57@119045|Methylobacteriaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,Abhydrolase_1,Guanylate_cyc,TPR_4 k59_1587466_1 330214.NIDE1418 1.86e-25 103.0 COG1386@1|root,COG1386@2|Bacteria,3J15Z@40117|Nitrospirae 40117|Nitrospirae D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_389028_1 395965.Msil_2987 1.39e-75 253.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,2U2F7@28211|Alphaproteobacteria,3NC95@45404|Beijerinckiaceae 28211|Alphaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_495087_1 694431.DESACE_06845 1.2e-23 99.4 COG3425@1|root,COG3425@2|Bacteria,1MU4K@1224|Proteobacteria,42M1Q@68525|delta/epsilon subdivisions,2WKSA@28221|Deltaproteobacteria 28221|Deltaproteobacteria I synthase mvaS - 2.3.3.10 ko:K01641 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130 M00088,M00095 R01978 RC00004,RC00503 ko00000,ko00001,ko00002,ko01000 - - - HMG_CoA_synt_C,HMG_CoA_synt_N k59_495087_2 342949.PNA2_1290 5.79e-57 191.0 COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,243BZ@183968|Thermococci 183968|Thermococci I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_653863_1 497321.C664_17987 2.24e-16 77.8 COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,2VKSW@28216|Betaproteobacteria,2KUYN@206389|Rhodocyclales 206389|Rhodocyclales M COG0810 Periplasmic protein TonB, links inner and outer membranes - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_653863_2 1123368.AUIS01000011_gene1156 1e-82 249.0 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,2NC7N@225057|Acidithiobacillales 225057|Acidithiobacillales K Belongs to the UPF0301 (AlgH) family - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_653863_3 455436.DS989814_gene834 0.000101 43.1 COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria,466VN@72275|Alteromonadaceae 1236|Gammaproteobacteria L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yqgF GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_1528908_1 70448.A0A096PAH0 1.06e-30 122.0 COG1004@1|root,KOG2666@2759|Eukaryota 2759|Eukaryota M UDP-glucose 6-dehydrogenase activity - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_701635_1 948106.AWZT01000015_gene763 2.82e-24 95.1 COG0251@1|root,COG0251@2|Bacteria,1RAKQ@1224|Proteobacteria,2VQPC@28216|Betaproteobacteria,1K21Z@119060|Burkholderiaceae 28216|Betaproteobacteria J endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_701635_2 1472418.BBJC01000006_gene2475 7.47e-19 85.5 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2TRUK@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the peptidase M20A family. ArgE subfamily MA20_31020 - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_1117739_2 1300345.LF41_2313 2.79e-16 78.2 COG2847@1|root,COG2847@2|Bacteria,1NDCJ@1224|Proteobacteria,1SG2J@1236|Gammaproteobacteria,1X7ZY@135614|Xanthomonadales 135614|Xanthomonadales S Copper chaperone PCu(A)C - - - ko:K09796 - - - - ko00000,ko03110 - - - PCuAC k59_909044_2 1205910.B005_5364 4.42e-42 157.0 COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,4EFWY@85012|Streptosporangiales 201174|Actinobacteria G Carbohydrate-binding module 48 (Isoamylase N-terminal domain) glgX - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_701639_1 998674.ATTE01000001_gene1198 2.19e-12 67.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,461K3@72273|Thiotrichales 72273|Thiotrichales V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_701639_2 640081.Dsui_3177 1.92e-55 180.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VKEW@28216|Betaproteobacteria,2KVSC@206389|Rhodocyclales 206389|Rhodocyclales V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_229456_1 1068980.ARVW01000001_gene8304 4.94e-46 168.0 COG3408@1|root,COG3408@2|Bacteria,2H2QX@201174|Actinobacteria,4E1W5@85010|Pseudonocardiales 201174|Actinobacteria G Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain - - 3.2.1.40 ko:K05989 - - - - ko00000,ko01000 - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,F5_F8_type_C k59_856714_1 246196.MSMEI_0647 2.44e-38 142.0 COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,234PD@1762|Mycobacteriaceae 201174|Actinobacteria Q NAD(P)-binding Rossmann-like domain - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_856714_2 446466.Cfla_1492 9.04e-26 106.0 COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria 201174|Actinobacteria E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_1488525_1 1123368.AUIS01000007_gene2733 1.19e-51 191.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2NBWY@225057|Acidithiobacillales 225057|Acidithiobacillales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1488525_2 1444309.JAQG01000012_gene2076 7.82e-08 60.8 COG0845@1|root,COG0845@2|Bacteria,1V5DX@1239|Firmicutes,4HMQM@91061|Bacilli,275J7@186822|Paenibacillaceae 91061|Bacilli M Barrel-sandwich domain of CusB or HlyD membrane-fusion yknX GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_960036_1 1121087.AUCK01000007_gene1655 1.57e-05 47.4 COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,4H9MW@91061|Bacilli,1ZBKI@1386|Bacillus 91061|Bacilli L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_174193_1 1333998.M2A_1569 1.66e-39 141.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2TRPG@28211|Alphaproteobacteria,4BPDK@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_439331_1 1004785.AMBLS11_02300 1.33e-29 120.0 COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,1RRU7@1236|Gammaproteobacteria,464KE@72275|Alteromonadaceae 1236|Gammaproteobacteria T GGDEF domain - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,GGDEF k59_811009_1 113355.CM001775_gene1169 4.11e-135 408.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1G0GP@1117|Cyanobacteria 1117|Cyanobacteria G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_126503_1 1123288.SOV_1c00940 3.59e-11 65.9 COG1493@1|root,COG1493@2|Bacteria,1V4IV@1239|Firmicutes 1239|Firmicutes T Serine kinase of the HPr protein, regulates carbohydrate metabolism hprK3 - - - - - - - - - - - ABC_tran,Hpr_kinase_C k59_960038_1 1432055.GLUCORHAEAF1_18815 1.92e-81 256.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2TUHH@28211|Alphaproteobacteria,2JPDC@204441|Rhodospirillales 204441|Rhodospirillales M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_334691_1 1121090.KB894695_gene1398 5.17e-69 225.0 COG0388@1|root,COG0388@2|Bacteria,1VT3W@1239|Firmicutes,4HUR1@91061|Bacilli,1ZM7S@1386|Bacillus 91061|Bacilli S Carbon-nitrogen hydrolase - - - - - - - - - - - - CN_hydrolase k59_1280962_1 555779.Dthio_PD1557 2.16e-07 61.2 COG2340@1|root,COG3291@1|root,COG2340@2|Bacteria,COG3291@2|Bacteria,1RCXG@1224|Proteobacteria,42SKT@68525|delta/epsilon subdivisions,2X89X@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Mycoplasma protein of unknown function, DUF285 - - - - - - - - - - - - DUF285 k59_1378434_1 713586.KB900536_gene2939 2.54e-68 231.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1WVV2@135613|Chromatiales 135613|Chromatiales C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_1117760_1 1229909.NSED_04200 1.73e-28 107.0 arCOG11446@1|root,arCOG11446@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1117760_2 1131266.ARWQ01000002_gene601 2.56e-36 125.0 COG1656@1|root,arCOG04290@2157|Archaea,41T6F@651137|Thaumarchaeota 651137|Thaumarchaeota S Mut7-C RNAse domain - - - - - - - - - - - - - k59_1225363_1 377629.TERTU_3296 3.28e-30 118.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,2PMII@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria O Hsp70 protein dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_811030_1 1123072.AUDH01000001_gene2897 6.08e-68 224.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Flavoprotein involved in K transport - - 1.14.13.22 ko:K03379 ko00930,ko01120,ko01220,map00930,map01120,map01220 - R02231,R06622 RC00662,RC01550 ko00000,ko00001,ko01000 - - - FMO-like,Pyr_redox_3 k59_960050_1 1469245.JFBG01000030_gene1547 6.98e-83 261.0 COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,1RQCM@1236|Gammaproteobacteria,1WXT8@135613|Chromatiales 135613|Chromatiales S PFAM Uncharacterised protein family UPF0118 - - - - - - - - - - - - AI-2E_transport k59_79256_1 1238182.C882_2060 1.09e-190 552.0 COG2185@1|root,COG2185@2|Bacteria,1QU3N@1224|Proteobacteria,2TVY1@28211|Alphaproteobacteria,2JPZR@204441|Rhodospirillales 204441|Rhodospirillales I Methylmalonyl-CoA mutase - - 5.4.99.63 ko:K14447 ko00630,ko01120,ko01200,map00630,map01120,map01200 M00373 R09292 RC02835 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase k59_282288_1 1492922.GY26_17210 2.64e-27 102.0 COG0236@1|root,COG0236@2|Bacteria,1N6RU@1224|Proteobacteria,1SCW1@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ acyl carrier protein RS00794 - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_282288_2 948106.AWZT01000005_gene4338 1.12e-16 74.3 COG0236@1|root,COG0236@2|Bacteria,1N7Q1@1224|Proteobacteria,2VVRR@28216|Betaproteobacteria,1K9MR@119060|Burkholderiaceae 28216|Betaproteobacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpM - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_1434867_1 132113.XP_003492787.1 3.91e-67 229.0 COG0124@1|root,COG0486@1|root,KOG1191@2759|Eukaryota,KOG1936@2759|Eukaryota,39U3H@33154|Opisthokonta,3CNF8@33208|Metazoa 33208|Metazoa J Histidyl-tRNA synthetase - - - - - - - - - - - - HGTP_anticodon,tRNA-synt_His k59_79275_2 1386969.AWTB01000093_gene4360 9.12e-46 153.0 COG2030@1|root,COG2030@2|Bacteria,2IMM1@201174|Actinobacteria,4GEEW@85026|Gordoniaceae 201174|Actinobacteria I MaoC like domain - - - - - - - - - - - - MaoC_dehydratas k59_1641626_1 1229909.NSED_08420 4.35e-64 201.0 COG0533@1|root,arCOG01185@2157|Archaea,41SJJ@651137|Thaumarchaeota 651137|Thaumarchaeota T Mn2 -dependent serine threonine protein kinase - - 2.7.11.1 ko:K08851 - - - - ko00000,ko01000,ko01001,ko03016 - - - Pkinase k59_701688_1 316274.Haur_4856 7.61e-16 82.8 COG3420@1|root,COG3420@2|Bacteria 2|Bacteria P alginic acid biosynthetic process quiC - 4.2.1.118 ko:K09483 ko00400,ko01110,ko01130,map00400,map01110,map01130 - R01627 RC00568 ko00000,ko00001,ko01000 - - - Beta_helix,CHU_C,NosD k59_1323538_1 1121904.ARBP01000012_gene1271 9.82e-23 101.0 COG0438@1|root,COG0438@2|Bacteria,4PKQN@976|Bacteroidetes,47K56@768503|Cytophagia 976|Bacteroidetes M PFAM glycogen synthase - - 2.4.1.11 ko:K00693 ko00500,ko01100,ko04151,ko04152,ko04910,ko04922,ko04931,map00500,map01100,map04151,map04152,map04910,map04922,map04931 - R00292 RC00005 ko00000,ko00001,ko01000,ko01003 - GT3 - Glycogen_syn k59_1587536_1 545264.KB898755_gene2830 1.62e-90 278.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WW29@135613|Chromatiales 135613|Chromatiales S PFAM Uncharacterised protein family UPF0027 rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_653956_1 694427.Palpr_0393 3.04e-06 51.2 COG0346@1|root,COG0346@2|Bacteria,4NNGG@976|Bacteroidetes,2FRZS@200643|Bacteroidia,22XX8@171551|Porphyromonadaceae 976|Bacteroidetes E methylmalonyl-CoA epimerase mce - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 k59_653956_2 373994.Riv7116_4395 2.51e-12 69.3 COG2358@1|root,COG2358@2|Bacteria,1G2YN@1117|Cyanobacteria,1HJUN@1161|Nostocales 1117|Cyanobacteria S NMT1-like family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_79296_1 545276.KB898728_gene180 1.14e-43 150.0 COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,1S6FG@1236|Gammaproteobacteria,1WY34@135613|Chromatiales 135613|Chromatiales S pfam ammecr1 - - - ko:K09141 - - - - ko00000 - - - AMMECR1 k59_439401_1 1163409.UUA_12138 2.82e-83 273.0 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1X2Z8@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - LAGLIDADG_3,Ribonuc_red_lgC k59_1065894_1 243233.MCA2186 2.18e-123 360.0 COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria,1XDTD@135618|Methylococcales 135618|Methylococcales IQ short-chain dehydrogenase reductase - - - - - - - - - - - - adh_short k59_1065894_2 1265503.KB905160_gene2964 8.52e-44 151.0 2C852@1|root,32YB2@2|Bacteria,1RH28@1224|Proteobacteria,1TK5M@1236|Gammaproteobacteria,2Q7JH@267889|Colwelliaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4136) - - - - - - - - - - - - DUF4136 k59_1065894_3 1266914.ATUK01000012_gene85 2.62e-26 99.8 COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,1SDIM@1236|Gammaproteobacteria,1WYSK@135613|Chromatiales 135613|Chromatiales J CRS1_YhbY - - - ko:K07574 - - - - ko00000,ko03009 - - - CRS1_YhbY k59_1065894_4 1002809.SSIL_2405 2.64e-05 48.1 COG0745@1|root,COG2198@1|root,COG2199@1|root,COG0745@2|Bacteria,COG2198@2|Bacteria,COG3706@2|Bacteria,1TSW8@1239|Firmicutes,4HBT1@91061|Bacilli,26DHT@186818|Planococcaceae 91061|Bacilli T diguanylate cyclase - - - - - - - - - - - - GGDEF,Hpt,Response_reg k59_1225420_1 314285.KT71_04705 7.79e-26 107.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1J7SH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031224,GO:0031226,GO:0031420,GO:0034220,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046983,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662 - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - iPC815.YPO3762,iSFV_1184.SFV_3651 TrkH k59_1065895_1 349521.HCH_06244 4.67e-25 105.0 2DA4I@1|root,32TUN@2|Bacteria,1N0WK@1224|Proteobacteria,1S6HI@1236|Gammaproteobacteria,1XK37@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_1065895_2 1415780.JPOG01000001_gene2827 2.98e-08 53.5 COG1664@1|root,COG1664@2|Bacteria,1PDPX@1224|Proteobacteria,1S9XY@1236|Gammaproteobacteria,1X6WV@135614|Xanthomonadales 135614|Xanthomonadales M cell shape determination - - - - - - - - - - - - Bactofilin k59_1378489_1 1288826.MSNKSG1_17748 1.28e-108 335.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,4648C@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_542552_1 1001240.GY21_14970 1.82e-34 132.0 COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,4FM3D@85023|Microbacteriaceae 201174|Actinobacteria G Inositol monophosphatase family hisN GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008934,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016020,GO:0016053,GO:0016137,GO:0016138,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052745,GO:0052803,GO:0052834,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659 3.1.3.15,3.1.3.25 ko:K01092,ko:K05602 ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070 M00026,M00131 R01185,R01186,R01187,R03013 RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_126585_2 439235.Dalk_2721 9.69e-16 76.3 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,42MU6@68525|delta/epsilon subdivisions,2WIJN@28221|Deltaproteobacteria,2MJ0P@213118|Desulfobacterales 28221|Deltaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_1117815_1 1380390.JIAT01000010_gene4326 6.69e-117 353.0 COG1229@1|root,COG1229@2|Bacteria 2|Bacteria C Formylmethanofuran dehydrogenase subunit A fhcA GO:0003674,GO:0003824,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0044237,GO:0044281 1.2.7.12 ko:K00200 ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200 M00567 R03015,R08060 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_3 k59_856792_1 1828.JOKB01000007_gene2582 1.96e-29 120.0 COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria,4FWZ5@85025|Nocardiaceae 201174|Actinobacteria Q cytochrome P450 - - - - - - - - - - - - p450 k59_1587562_1 713586.KB900536_gene2837 2.89e-192 548.0 COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,1RQ44@1236|Gammaproteobacteria,1X080@135613|Chromatiales 135613|Chromatiales C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_1587562_2 765913.ThidrDRAFT_0869 2.11e-10 58.2 COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1S6B0@1236|Gammaproteobacteria,1WYPJ@135613|Chromatiales 135613|Chromatiales P PFAM Rieske 2Fe-2S - - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske k59_1225453_2 215803.DB30_8299 9.78e-17 82.8 COG3391@1|root,COG3391@2|Bacteria,1R7E0@1224|Proteobacteria,42XD8@68525|delta/epsilon subdivisions,2X34S@28221|Deltaproteobacteria,2YU9J@29|Myxococcales 28221|Deltaproteobacteria S TIGRFAM 40-residue YVTN family beta-propeller repeat - - - - - - - - - - - - Cytochrom_D1 k59_174263_1 1195236.CTER_2501 1.53e-09 60.1 COG2703@1|root,COG2703@2|Bacteria,1VBEC@1239|Firmicutes,24NV2@186801|Clostridia 186801|Clostridia P Hemerythrin HHE cation binding domain - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k59_653999_1 856793.MICA_240 5.77e-55 182.0 COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2TSUU@28211|Alphaproteobacteria,4BPZ3@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria EH dehydrogenase and related dehydrogenases ghrA - 1.1.1.79,1.1.1.81 ko:K12972 ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120 - R00465,R01388,R01392,R02527 RC00031,RC00042,RC00670 ko00000,ko00001,ko01000 - - - 2-Hacid_dh_C k59_811124_1 1242864.D187_009831 1.6e-25 109.0 2DMMW@1|root,32SIJ@2|Bacteria,1N004@1224|Proteobacteria,42TSJ@68525|delta/epsilon subdivisions,2WQHG@28221|Deltaproteobacteria,2YV84@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_334771_1 395493.BegalDRAFT_2604 2.27e-98 299.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,45ZXN@72273|Thiotrichales 72273|Thiotrichales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_1488661_1 37919.EP51_01650 8.77e-72 244.0 COG0147@1|root,COG0512@1|root,COG2890@1|root,COG0147@2|Bacteria,COG0512@2|Bacteria,COG2890@2|Bacteria,2GKJT@201174|Actinobacteria,4FUGP@85025|Nocardiaceae 201174|Actinobacteria EH Anthranilate synthase component I, N terminal region pabB - 2.6.1.85,4.1.3.27,4.1.3.38 ko:K01657,ko:K01665,ko:K03342,ko:K13950 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716,R05553 RC00010,RC01418,RC01843,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4,Anth_synt_I_N,Chorismate_bind,GATase k59_654015_1 1380390.JIAT01000009_gene1091 3.8e-21 90.5 COG0179@1|root,COG0179@2|Bacteria,2GKED@201174|Actinobacteria 201174|Actinobacteria Q PFAM fumarylacetoacetate (FAA) hydrolase - - - - - - - - - - - - DUF2437,FAA_hydrolase k59_654015_2 402881.Plav_1611 6.06e-46 156.0 COG0596@1|root,COG0596@2|Bacteria 2|Bacteria S hydrolase activity, acting on ester bonds dhaA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009410,GO:0009987,GO:0016020,GO:0016787,GO:0016824,GO:0018786,GO:0019120,GO:0030312,GO:0042178,GO:0042197,GO:0042206,GO:0042221,GO:0044237,GO:0044248,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071466,GO:0071704,GO:0071944,GO:1901575 3.8.1.5 ko:K01563 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1117839_1 420324.KI911970_gene1565 4.73e-81 253.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2TSX2@28211|Alphaproteobacteria,1JXGQ@119045|Methylobacteriaceae 28211|Alphaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_335989_1 1131266.ARWQ01000002_gene485 1.26e-95 287.0 COG1899@1|root,arCOG04142@2157|Archaea,41SWS@651137|Thaumarchaeota 651137|Thaumarchaeota O Deoxyhypusine synthase - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS k59_1067161_2 378806.STAUR_6808 1.66e-97 300.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ4Z@28221|Deltaproteobacteria,2YXJE@29|Myxococcales 28221|Deltaproteobacteria NU twitching motility protein pilT1 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_961450_1 349521.HCH_00228 2.78e-32 119.0 COG0454@1|root,COG0456@2|Bacteria,1QU0C@1224|Proteobacteria,1S503@1236|Gammaproteobacteria,1XKTZ@135619|Oceanospirillales 135619|Oceanospirillales K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 k59_1014309_1 1123054.KB907727_gene3066 6.42e-21 90.9 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,1WW91@135613|Chromatiales 135613|Chromatiales D TIGRFAM Cell shape determining protein MreB Mrl - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_1175244_1 1137799.GZ78_16070 3.7e-39 147.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,1XMWY@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1596494_1 717774.Marme_0297 7.98e-77 254.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1XHN6@135619|Oceanospirillales 135619|Oceanospirillales J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_138065_1 1242864.D187_004612 6.06e-52 177.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,42NBS@68525|delta/epsilon subdivisions,2WIP2@28221|Deltaproteobacteria,2YUVJ@29|Myxococcales 28221|Deltaproteobacteria H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1624 RibD_C,dCMP_cyt_deam_1 k59_1293633_1 196367.JNFG01000202_gene2587 5.55e-44 163.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,1K119@119060|Burkholderiaceae 28216|Betaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_920078_2 5062.CADAORAP00009247 4.95e-09 58.5 COG1028@1|root,KOG0725@2759|Eukaryota,39S2Z@33154|Opisthokonta,3NUW0@4751|Fungi,3QRYR@4890|Ascomycota,20AU6@147545|Eurotiomycetes,3S3QV@5042|Eurotiales 4751|Fungi Q Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short,adh_short_C2 k59_14388_1 717774.Marme_1052 2.66e-27 111.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1XIX5@135619|Oceanospirillales 135619|Oceanospirillales L Belongs to the DNA photolyase family phrB - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_451039_1 396588.Tgr7_2114 1.84e-89 290.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales 135613|Chromatiales Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_1293649_1 926560.KE387026_gene4319 6.55e-16 77.8 COG3653@1|root,COG3653@2|Bacteria,1WM1K@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_1293649_2 1206741.BAFX01000101_gene1514 4.18e-34 124.0 COG1515@1|root,COG1515@2|Bacteria,2GJEZ@201174|Actinobacteria,4FYCB@85025|Nocardiaceae 201174|Actinobacteria L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA nfi - 3.1.21.7 ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 k59_14389_1 1033802.SSPSH_000149 1.8e-16 77.0 COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_14389_2 90814.KL370891_gene1782 1.07e-53 182.0 COG0342@1|root,COG0342@2|Bacteria,1MVFS@1224|Proteobacteria,1RYCF@1236|Gammaproteobacteria,461NY@72273|Thiotrichales 72273|Thiotrichales U glutamate--cysteine ligase - - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - GshA k59_293030_1 1121405.dsmv_3333 7.59e-23 103.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg k59_1293651_1 1209072.ALBT01000023_gene3949 1.5e-24 112.0 COG0421@1|root,COG0421@2|Bacteria,1QVJA@1224|Proteobacteria,1RYYT@1236|Gammaproteobacteria,1FI1C@10|Cellvibrio 1236|Gammaproteobacteria E Spermine/spermidine synthase domain - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_451048_2 159749.K0TL23 8.95e-06 53.1 COG0475@1|root,KOG1650@2759|Eukaryota,2XA8T@2836|Bacillariophyta 2836|Bacillariophyta P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_1501182_1 438753.AZC_3365 6.32e-20 87.4 COG0625@1|root,COG0625@2|Bacteria,1Q05U@1224|Proteobacteria,2U5IH@28211|Alphaproteobacteria,3F1FU@335928|Xanthobacteraceae 28211|Alphaproteobacteria O Glutathione S-transferase, C-terminal domain - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_345150_2 1328313.DS2_06551 6.72e-24 103.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,464VA@72275|Alteromonadaceae 1236|Gammaproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048 Formyl_trans_C,Formyl_trans_N k59_1331580_1 1469245.JFBG01000074_gene99 2.18e-178 506.0 COG0482@1|root,COG0482@2|Bacteria,1QV6H@1224|Proteobacteria,1RQSV@1236|Gammaproteobacteria 1236|Gammaproteobacteria J tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain - - - - - - - - - - - - ThiI,tRNA_Me_trans k59_551781_1 457398.HMPREF0326_03083 2.27e-53 189.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2M8QH@213115|Desulfovibrionales 28221|Deltaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_823820_1 1254432.SCE1572_18885 3.14e-34 134.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2WIQ7@28221|Deltaproteobacteria,2YTZJ@29|Myxococcales 28221|Deltaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1654497_1 713586.KB900536_gene2307 1.06e-47 158.0 COG1522@1|root,COG1522@2|Bacteria,1NVYY@1224|Proteobacteria,1S620@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG1522 Transcriptional regulators nirL - - - - - - - - - - - HTH_AsnC-type k59_1654497_2 713586.KB900536_gene2306 4.82e-55 176.0 COG1522@1|root,COG1522@2|Bacteria,1NVYY@1224|Proteobacteria,1SZR6@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG1522 Transcriptional regulators - - - - - - - - - - - - - k59_969505_1 1333998.M2A_3056 3.23e-33 123.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2U758@28211|Alphaproteobacteria,4BQKN@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the ompA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_1387003_1 391595.RLO149_c036830 3.22e-101 305.0 COG0075@1|root,COG0075@2|Bacteria,1R4JQ@1224|Proteobacteria,2TV9E@28211|Alphaproteobacteria,2P0Y0@2433|Roseobacter 28211|Alphaproteobacteria H Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 k59_1536897_1 1198114.AciX9_4589 2.75e-28 116.0 COG0438@1|root,COG0438@2|Bacteria,3Y2F3@57723|Acidobacteria,2JIQ3@204432|Acidobacteriia 204432|Acidobacteriia M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1536897_2 262724.TT_C0284 6.88e-126 371.0 COG0399@1|root,COG0399@2|Bacteria,1WJBP@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_920130_1 570967.JMLV01000010_gene1265 4.42e-107 333.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,2JRC3@204441|Rhodospirillales 204441|Rhodospirillales E FAD dependent oxidoreductase central domain - - - - - - - - - - - - DAO,FAO_M,GCV_T,GCV_T_C k59_345173_1 65497.JODV01000001_gene3708 4.14e-21 95.5 COG1587@1|root,COG1587@2|Bacteria,2GKMM@201174|Actinobacteria,4E89G@85010|Pseudonocardiales 201174|Actinobacteria H Uroporphyrinogen-III synthase HemD hemD - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4,Trans_reg_C k59_1237324_1 1335757.SPICUR_07145 1.68e-33 128.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1WWQM@135613|Chromatiales 135613|Chromatiales P CBS domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1237324_3 349521.HCH_02302 5.6e-55 175.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1XK7A@135619|Oceanospirillales 135619|Oceanospirillales O Belongs to the MsrB Met sulfoxide reductase family msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_1331595_1 1040983.AXAE01000013_gene5688 2.48e-31 113.0 2E08V@1|root,32VWG@2|Bacteria,1N52T@1224|Proteobacteria,2UU4P@28211|Alphaproteobacteria,43KVE@69277|Phyllobacteriaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_823845_1 1146883.BLASA_0999 2.62e-15 77.8 COG3291@1|root,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - - - - - - - - - - - PA,PKD k59_823845_2 1442599.JAAN01000020_gene2558 1.44e-05 47.0 COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,1X4DS@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the agmatine deiminase family - - - - - - - - - - - - PAD_porph k59_710915_1 929712.KI912613_gene3111 2.8e-31 118.0 COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4CPTW@84995|Rubrobacteria 84995|Rubrobacteria C Zinc-binding dehydrogenase - - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_710916_1 330214.NIDE3957 2.36e-57 191.0 COG0042@1|root,COG0042@2|Bacteria 2|Bacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dus - - ko:K05541 - - - - ko00000,ko01000,ko03016 - - - Dus k59_138141_1 1293054.HSACCH_01809 4.88e-05 51.6 COG4775@1|root,COG4775@2|Bacteria,1UMDS@1239|Firmicutes,24F0X@186801|Clostridia,3WAA6@53433|Halanaerobiales 186801|Clostridia M PFAM Surface antigen variable number repeat - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1293714_1 1357275.AVEL02000092_gene2951 2.16e-33 125.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1Z676@136849|Pseudomonas syringae group 1236|Gammaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641 DFP,Flavoprotein k59_1237338_1 1178482.BJB45_00910 1.12e-31 115.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,1S20I@1236|Gammaproteobacteria,1XJ74@135619|Oceanospirillales 135619|Oceanospirillales E acetolactate synthase ilvH - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT_5,ALS_ss_C k59_1237338_2 930169.B5T_03694 3.61e-41 145.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1XIH7@135619|Oceanospirillales 135619|Oceanospirillales EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_1128778_1 1496688.ER33_15360 2.41e-98 302.0 COG2308@1|root,COG2308@2|Bacteria 2|Bacteria S glutamate-cysteine ligase activity - - - - - - - - - - - - - k59_1331604_1 1045009.AFXQ01000006_gene1039 1.02e-27 108.0 COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria,1WCGJ@1268|Micrococcaceae 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059,ko:K07535 ko00061,ko00333,ko00362,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,ko01220,map00061,map00333,map00362,map00780,map01040,map01100,map01120,map01130,map01212,map01220 M00083,M00540,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R05582,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117,RC00154 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1331604_2 78245.Xaut_4349 2.93e-30 121.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2TVGG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S AI-2E family transporter MA20_41055 - - - - - - - - - - - AI-2E_transport k59_710923_1 1300345.LF41_2183 7.73e-26 100.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1X41Q@135614|Xanthomonadales 135614|Xanthomonadales EH with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine trpG - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_710923_2 1121935.AQXX01000117_gene5090 3.65e-83 256.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1XIT8@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_1654545_1 329726.AM1_1742 2.36e-80 254.0 COG4313@1|root,COG4313@2|Bacteria,1G150@1117|Cyanobacteria 1117|Cyanobacteria C Protein involved in meta-pathway of phenol degradation - - - - - - - - - - - - Phenol_MetA_deg k59_970560_1 867903.ThesuDRAFT_00843 6.18e-13 73.6 COG1276@1|root,COG2010@1|root,COG1276@2|Bacteria,COG2010@2|Bacteria 2|Bacteria C Cytochrome c copC - - ko:K07245,ko:K14166 - - - - ko00000,ko02000 9.B.62.1 - - AhpC-TSA,CopC,CopD,Cytochrome_CBB3 k59_92957_1 267608.RSc2161 1.72e-48 169.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,1K01J@119060|Burkholderiaceae 28216|Betaproteobacteria H Involved in the biosynthesis of porphyrin-containing compound hemN2 - - - - - - - - - - - HemN_C,Radical_SAM k59_92957_2 1307759.JOMJ01000004_gene2828 3.2e-23 95.5 2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,42QRD@68525|delta/epsilon subdivisions,2WMYW@28221|Deltaproteobacteria,2MC9C@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF4197) - - - - - - - - - - - - DUF4197 k59_509410_1 330214.NIDE0726 1.13e-11 63.9 COG0841@1|root,COG0841@2|Bacteria,3J0ZG@40117|Nitrospirae 40117|Nitrospirae V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_509410_2 330214.NIDE0727 1.54e-64 209.0 COG0845@1|root,COG0845@2|Bacteria,3J15F@40117|Nitrospirae 40117|Nitrospirae M HlyD family secretion protein - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_866905_1 765912.Thimo_0588 1.72e-74 234.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_398015_2 75379.Tint_0842 2.07e-41 143.0 COG0500@1|root,COG0500@2|Bacteria,1QVHC@1224|Proteobacteria,2VS83@28216|Betaproteobacteria,1KKW7@119065|unclassified Burkholderiales 28216|Betaproteobacteria Q Thiopurine S-methyltransferase (TPMT) - - - - - - - - - - - - TPMT k59_509414_1 1120970.AUBZ01000007_gene3015 1.2e-05 47.4 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,4666V@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine nifS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_509414_2 1232410.KI421419_gene2502 1.33e-22 95.1 COG3103@1|root,COG4991@2|Bacteria,1QWMT@1224|Proteobacteria,42VQW@68525|delta/epsilon subdivisions,2WR75@28221|Deltaproteobacteria,43SNN@69541|Desulfuromonadales 28221|Deltaproteobacteria T Bacterial SH3 domain homologues - - - ko:K07184 - - - - ko00000 - - - SH3_3 k59_92968_1 697282.Mettu_2014 2.03e-73 227.0 COG4229@1|root,COG4229@2|Bacteria,1R3V9@1224|Proteobacteria,1RP5Y@1236|Gammaproteobacteria,1XE85@135618|Methylococcales 135618|Methylococcales C Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene) mtnC - 3.1.3.77 ko:K09880 ko00270,ko01100,map00270,map01100 M00034 R07395 RC02779 ko00000,ko00001,ko00002,ko01000 - - - - k59_825374_1 1184267.A11Q_1029 4.36e-08 54.3 COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,42RXS@68525|delta/epsilon subdivisions,2MT64@213481|Bdellovibrionales,2WNA0@28221|Deltaproteobacteria 213481|Bdellovibrionales K PFAM Transcription factor CarD - - - ko:K07736 - - - - ko00000,ko03000 - - - CarD_CdnL_TRCF k59_294346_1 1112217.PPL19_16370 2.88e-12 69.7 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_346384_1 1089552.KI911559_gene1176 5.49e-27 112.0 COG1463@1|root,COG1463@2|Bacteria,1Q6ZU@1224|Proteobacteria,2VGI9@28211|Alphaproteobacteria,2JT3S@204441|Rhodospirillales 204441|Rhodospirillales Q MlaD protein - - - ko:K06192 - - - - ko00000 - - - MlaD k59_1130037_1 765914.ThisiDRAFT_1750 4.96e-100 314.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1WWDE@135613|Chromatiales 135613|Chromatiales T Belongs to the PEP-utilizing enzyme family - - 2.7.3.9 ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_1238802_1 536019.Mesop_2378 1.49e-40 150.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,2TU12@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB k59_398031_2 1229909.NSED_03250 2.57e-31 110.0 arCOG08753@1|root,arCOG08753@2157|Archaea,41T9W@651137|Thaumarchaeota 651137|Thaumarchaeota C 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - - k59_921420_1 944564.HMPREF9200_0114 1.2e-11 70.5 COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,4H21Y@909932|Negativicutes 909932|Negativicutes H Involved in the biosynthesis of porphyrin-containing compound hemN - - - - - - - - - - - HemN_C,Radical_SAM k59_1130043_1 411684.HPDFL43_10012 6.01e-94 281.0 COG3638@1|root,COG3638@2|Bacteria,1MVE9@1224|Proteobacteria,2TRR3@28211|Alphaproteobacteria,43JSG@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system phnC - 3.6.3.28 ko:K02041 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.9 - - ABC_tran k59_605105_1 338963.Pcar_0105 2.04e-35 143.0 COG0683@1|root,COG0683@2|Bacteria,1R8IG@1224|Proteobacteria,42N7H@68525|delta/epsilon subdivisions,2WIUQ@28221|Deltaproteobacteria,43S82@69541|Desulfuromonadales 28221|Deltaproteobacteria E LppC putative lipoprotein - - - ko:K07121 - - - - ko00000 - - - LppC,Peripla_BP_6,TPR_16,TPR_6 k59_1332559_1 314345.SPV1_05919 3.89e-70 223.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria 1224|Proteobacteria F Belongs to the phosphoglycerate kinase family pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - iSbBS512_1146.SbBS512_E3351 PGK k59_970589_1 1121935.AQXX01000076_gene5401 8.42e-56 195.0 COG0673@1|root,COG1063@1|root,COG0673@2|Bacteria,COG1063@2|Bacteria,1QV3S@1224|Proteobacteria,1RRI1@1236|Gammaproteobacteria,1XR4T@135619|Oceanospirillales 135619|Oceanospirillales E Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - ADH_zinc_N,GFO_IDH_MocA,GFO_IDH_MocA_C k59_1176349_1 1229909.NSED_09145 1.17e-115 339.0 COG0704@1|root,arCOG00318@2157|Archaea,41T1H@651137|Thaumarchaeota 651137|Thaumarchaeota P Phosphate uptake regulator - - - - - - - - - - - - PhoU k59_346408_1 238854.Q5GQI7_BPSYP 2.93e-125 379.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QI6A@10662|Myoviridae 10662|Myoviridae S Ribonucleotide reductase, barrel domain - - - - - - - - - - - - - k59_1023156_2 1123072.AUDH01000015_gene2129 1.59e-51 166.0 COG1917@1|root,COG1917@2|Bacteria,1RB4Y@1224|Proteobacteria,2U5J9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Cupin domain MA20_40115 - - - - - - - - - - - Cupin_2 k59_1023156_3 177439.DP0087 3.42e-57 195.0 COG0318@1|root,COG0318@2|Bacteria,1QVGC@1224|Proteobacteria,43BUA@68525|delta/epsilon subdivisions 1224|Proteobacteria IQ AMP-binding enzyme C-terminal domain - - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding k59_1023162_1 530564.Psta_1177 1.36e-17 84.0 COG2040@1|root,COG2040@2|Bacteria,2J3GR@203682|Planctomycetes 203682|Planctomycetes H Homocysteine S-methyltransferase - - 2.1.1.10 ko:K00547 ko00270,ko01100,ko01110,map00270,map01100,map01110 - R00650 RC00003,RC00035 ko00000,ko00001,ko01000 - - - S-methyl_trans k59_1571722_1 862965.PARA_03470 2.65e-71 238.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1Y6SS@135625|Pasteurellales 135625|Pasteurellales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_840767_1 518766.Rmar_2433 7.5e-72 242.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,4NFRF@976|Bacteroidetes,1FJP0@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E B12 binding domain metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_213841_2 713587.THITH_07945 3.28e-28 112.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1WWFA@135613|Chromatiales 135613|Chromatiales E PFAM Prephenate dehydratase - - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_108991_2 224325.AF_1619 4.5e-26 107.0 arCOG03874@1|root,arCOG03874@2157|Archaea 2157|Archaea S Conserved hypothetical protein 698 - - - - - - - - - - - - Cons_hypoth698 k59_685151_1 875328.JDM601_3502 5.3e-14 71.2 COG2128@1|root,COG2128@2|Bacteria,2IAT6@201174|Actinobacteria,238XY@1762|Mycobacteriaceae 201174|Actinobacteria S carboxymuconolactone decarboxylase - - - - - - - - - - - - CMD k59_685151_2 653045.Strvi_4549 7.3e-14 74.7 COG1028@1|root,COG3386@1|root,COG1028@2|Bacteria,COG3386@2|Bacteria,2GM3I@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short,adh_short_C2 k59_1310692_1 999549.KI421513_gene2261 8.98e-86 280.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,28242@191028|Leisingera 28211|Alphaproteobacteria T Adenylate cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,TPR_8,TolB_N k59_108996_1 1249975.JQLP01000005_gene2418 4.33e-38 144.0 COG2170@1|root,COG2170@2|Bacteria,4NGA3@976|Bacteroidetes,1HXM0@117743|Flavobacteriia,2P6AD@244698|Gillisia 976|Bacteroidetes S Glutamate-cysteine ligase family 2(GCS2) - - - ko:K06048 - - - - ko00000,ko01000 - - - GCS2 k59_1363110_1 877414.ATWA01000055_gene726 1.23e-44 156.0 COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,268HU@186813|unclassified Clostridiales 186801|Clostridia J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1154115_1 903818.KI912268_gene1854 3.09e-30 132.0 28JHJ@1|root,2Z9B3@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1467982_1 1432050.IE4771_CH03257 1e-65 226.0 COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,2TV9Y@28211|Alphaproteobacteria,4B7WH@82115|Rhizobiaceae 28211|Alphaproteobacteria S Von Willebrand factor type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_1467982_2 1049564.TevJSym_ab01380 2.43e-26 109.0 COG2885@1|root,COG2885@2|Bacteria,1RIG3@1224|Proteobacteria,1S5WW@1236|Gammaproteobacteria,1JAQP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M OmpA family - - - - - - - - - - - - DUF4398,OmpA k59_840784_1 713586.KB900536_gene1694 1.62e-20 85.1 COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,1WY6S@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02657 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_1049736_1 1089546.AQUI01000002_gene1155 2.67e-105 322.0 COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,407FI@622450|Actinopolysporales 201174|Actinobacteria C FAD linked oxidases, C-terminal domain glcD - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1049736_2 1246474.ANBE01000046_gene4524 1.35e-32 131.0 COG0277@1|root,COG0277@2|Bacteria,2H3K3@201174|Actinobacteria,4EGYG@85012|Streptosporangiales 201174|Actinobacteria C FAD binding domain - - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 k59_736198_1 502025.Hoch_5483 2.46e-14 75.5 COG4446@1|root,COG4446@2|Bacteria,1N31A@1224|Proteobacteria,433JZ@68525|delta/epsilon subdivisions,2WXZQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function (DUF1499) - - - - - - - - - - - - DUF1499 k59_213860_1 330214.NIDE2638 1.74e-82 268.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,3J0ZS@40117|Nitrospirae 40117|Nitrospirae C FAD linked oxidases, C-terminal domain - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_893180_1 436308.Nmar_0752 4.01e-37 129.0 arCOG10543@1|root,arCOG10543@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_267026_1 4920.XP_004194260.1 0.000154 43.1 COG0288@1|root,2RXIV@2759|Eukaryota,3A0V8@33154|Opisthokonta,3P2JY@4751|Fungi,3QUCT@4890|Ascomycota,3RWAI@4891|Saccharomycetes,47CQZ@766764|Debaryomycetaceae 4751|Fungi H Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_267026_2 441620.Mpop_3619 7.01e-69 211.0 COG3631@1|root,COG3631@2|Bacteria,1RISB@1224|Proteobacteria,2UAAK@28211|Alphaproteobacteria,1JXU2@119045|Methylobacteriaceae 28211|Alphaproteobacteria S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL k59_1260874_1 314345.SPV1_14254 7.36e-26 97.8 COG1977@1|root,COG1977@2|Bacteria,1N4Z0@1224|Proteobacteria 1224|Proteobacteria H Molybdopterin converting factor, small subunit - - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_319655_1 667014.Thein_1489 1.65e-49 164.0 COG0522@1|root,COG0522@2|Bacteria,2GGS1@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_319655_2 991905.SL003B_1763 1.36e-52 177.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2TSI0@28211|Alphaproteobacteria,4BPAZ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_423642_2 443144.GM21_0757 6.74e-18 85.9 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42S69@68525|delta/epsilon subdivisions,2X5TT@28221|Deltaproteobacteria,43V4F@69541|Desulfuromonadales 28221|Deltaproteobacteria NT PFAM CheW domain protein cheW40H-1 - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_423642_3 204669.Acid345_1771 2.49e-11 67.8 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,3Y40G@57723|Acidobacteria,2JIXP@204432|Acidobacteriia 204432|Acidobacteriia T Signal transducing histidine kinase, homodimeric domain - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_160664_1 886293.Sinac_5963 1.32e-17 83.6 COG3119@1|root,COG3119@2|Bacteria,2IX0S@203682|Planctomycetes 203682|Planctomycetes P COG3119 Arylsulfatase A - - - - - - - - - - - - Sulfatase k59_160664_2 388413.ALPR1_17883 1.52e-16 80.1 COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,47JYR@768503|Cytophagia 976|Bacteroidetes P PFAM sulfatase - - - - - - - - - - - - DUF4976,Sulfatase k59_214601_1 207559.Dde_3641 8.85e-100 319.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,43AD6@68525|delta/epsilon subdivisions,2WJCC@28221|Deltaproteobacteria,2M8PA@213115|Desulfovibrionales 28221|Deltaproteobacteria P transporter antisigma-factor antagonist STAS - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_894010_1 472759.Nhal_0174 9.67e-117 341.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,1WW7W@135613|Chromatiales 135613|Chromatiales E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_1260900_1 543632.JOJL01000011_gene6710 2.31e-10 63.5 COG1960@1|root,COG1960@2|Bacteria,2GIXS@201174|Actinobacteria,4D8Z3@85008|Micromonosporales 201174|Actinobacteria I Acyl-CoA dehydrogenase, middle domain fadE29 GO:0000166,GO:0003674,GO:0005488,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016125,GO:0016127,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044110,GO:0044116,GO:0044117,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0046164,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0051704,GO:0055114,GO:0071704,GO:0071949,GO:0072329,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652 - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1260900_2 479432.Sros_8196 1.12e-13 71.2 COG1545@1|root,COG2030@1|root,COG1545@2|Bacteria,COG2030@2|Bacteria,2GM2A@201174|Actinobacteria,4EFYI@85012|Streptosporangiales 201174|Actinobacteria Q Rubredoxin-like zinc ribbon domain (DUF35_N) - - - ko:K07068 - - - - ko00000 - - - DUF35_N,MaoC_dehydrat_N,OB_aCoA_assoc k59_214605_1 641491.DND132_0948 2.57e-48 174.0 COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,42M49@68525|delta/epsilon subdivisions,2WJ5G@28221|Deltaproteobacteria,2M8QA@213115|Desulfovibrionales 28221|Deltaproteobacteria J elongation factor SelB, winged helix selB - - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 k59_1518790_1 1163409.UUA_16593 5.59e-151 433.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1X46A@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_423652_1 1380394.JADL01000011_gene3969 4.14e-87 271.0 COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,2TTUK@28211|Alphaproteobacteria,2JSPQ@204441|Rhodospirillales 204441|Rhodospirillales E Pyridoxal-dependent decarboxylase conserved domain - - - - - - - - - - - - Pyridoxal_deC k59_841572_1 436308.Nmar_0167 3.1e-10 60.1 COG0166@1|root,arCOG00052@2157|Archaea 2157|Archaea G Belongs to the GPI family pgi GO:0003674,GO:0003824,GO:0004340,GO:0004347,GO:0004396,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046939,GO:0051156,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.3.1.8,5.3.1.9 ko:K01810,ko:K15916 ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R01819,R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI,SIS,bact-PGI_C k59_59503_1 243233.MCA0880 1.86e-20 90.1 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1XEW1@135618|Methylococcales 135618|Methylococcales C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_59503_2 472759.Nhal_0063 1.02e-15 75.1 COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,1S5XA@1236|Gammaproteobacteria,1X0T0@135613|Chromatiales 135613|Chromatiales O PFAM Cytochrome c oxidase assembly protein CtaG Cox11 - - - ko:K02258 ko00190,ko01100,ko04714,map00190,map01100,map04714 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.8 - - CtaG_Cox11 k59_371405_1 436308.Nmar_0282 1.58e-68 211.0 COG0839@1|root,arCOG04654@2157|Archaea,41SM8@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6 - - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_371405_2 436308.Nmar_0283 3.87e-54 171.0 COG0713@1|root,arCOG03073@2157|Archaea,41SPM@651137|Thaumarchaeota 651137|Thaumarchaeota C NADH ubiquinone oxidoreductase subunit 11 or 4L (chain K) - - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_371405_3 1229909.NSED_01320 7.82e-51 174.0 COG1009@1|root,arCOG01539@2157|Archaea,41TBF@651137|Thaumarchaeota 651137|Thaumarchaeota C Proton-conducting membrane transporter - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1102872_1 1380394.JADL01000017_gene479 1.31e-56 191.0 COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria,2JR2A@204441|Rhodospirillales 204441|Rhodospirillales J Amidase - - - - - - - - - - - - Amidase k59_686202_1 760568.Desku_0993 0.000295 44.7 COG0664@1|root,COG0664@2|Bacteria,1V3XW@1239|Firmicutes,24HXX@186801|Clostridia,262JG@186807|Peptococcaceae 186801|Clostridia K PFAM Cyclic nucleotide-binding - - - ko:K10914,ko:K21563 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_686202_2 96561.Dole_0426 8.99e-16 85.5 COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria,2MHU3@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_4,PAS_9,sCache_3_2 k59_1311553_1 439235.Dalk_5205 3.38e-55 186.0 COG2807@1|root,COG2807@2|Bacteria,1QW3Y@1224|Proteobacteria,42MUB@68525|delta/epsilon subdivisions,2WIX2@28221|Deltaproteobacteria,2MJ4V@213118|Desulfobacterales 28221|Deltaproteobacteria P Major facilitator superfamily - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_1469040_1 177437.HRM2_34710 5.07e-45 152.0 COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,42TGN@68525|delta/epsilon subdivisions,2WQ04@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Haloacid dehalogenase-like hydrolase - - 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 k59_841582_1 1487953.JMKF01000048_gene2065 1.79e-80 246.0 COG1515@1|root,COG1515@2|Bacteria,1G2HF@1117|Cyanobacteria,1H8TY@1150|Oscillatoriales 1117|Cyanobacteria L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA nfi - 3.1.21.7 ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 k59_841582_2 1304275.C41B8_02532 7.47e-18 80.9 COG2818@1|root,COG2818@2|Bacteria,1R3WB@1224|Proteobacteria,1RSAH@1236|Gammaproteobacteria 1236|Gammaproteobacteria L 3-Methyladenine DNA glycosylase IV02_03670 - - - - - - - - - - - Adenine_glyco k59_1260922_1 436308.Nmar_0657 8.07e-58 191.0 COG1262@1|root,arCOG03517@2157|Archaea,41T1B@651137|Thaumarchaeota 651137|Thaumarchaeota S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase k59_1260922_2 1229909.NSED_07540 2.61e-18 83.2 COG0731@1|root,arCOG00953@2157|Archaea 2157|Archaea C Radical SAM domain protein rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM k59_1416164_1 756272.Plabr_4807 1.43e-39 150.0 COG0793@1|root,COG0793@2|Bacteria,2IXI9@203682|Planctomycetes 203682|Planctomycetes M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - DUF3340,PDZ,Peptidase_S41 k59_1469045_1 472759.Nhal_0585 8.99e-66 205.0 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S5Y0@1236|Gammaproteobacteria,1WYXN@135613|Chromatiales 135613|Chromatiales Q PFAM Tripartite ATP-independent periplasmic transporter, DctQ component - - - - - - - - - - - - DctQ k59_894034_1 762903.Pedsa_1107 4.08e-29 120.0 COG0415@1|root,COG0415@2|Bacteria,4NEDW@976|Bacteroidetes,1IQZJ@117747|Sphingobacteriia 976|Bacteroidetes L DNA photolyase phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_371424_1 640081.Dsui_3008 8.46e-16 76.3 COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,2VJ4W@28216|Betaproteobacteria,2KWRP@206389|Rhodocyclales 206389|Rhodocyclales C Hydrogenase maturation protease - - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI k59_371424_2 2340.JV46_26670 0.000123 43.9 2DNYF@1|root,32ZSU@2|Bacteria,1N8ZB@1224|Proteobacteria,1S5ZH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM HupH hydrogenase expression protein - - - ko:K03618 - - - - ko00000 - - - HupH_C k59_686223_1 463191.SSEG_08603 3.94e-31 119.0 COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_686223_2 1120936.KB907210_gene5519 1.84e-33 123.0 COG2141@1|root,COG2141@2|Bacteria,2GMMJ@201174|Actinobacteria,4EGKE@85012|Streptosporangiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1260934_1 376733.IT41_19950 2.91e-97 295.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TTAW@28211|Alphaproteobacteria,2PZC6@265|Paracoccus 28211|Alphaproteobacteria L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_686228_1 269799.Gmet_2718 4.57e-65 212.0 COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,42T39@68525|delta/epsilon subdivisions,2WR3E@28221|Deltaproteobacteria 28221|Deltaproteobacteria KLT Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase k59_1260941_1 1123393.KB891317_gene2479 2.95e-63 207.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2W3RM@28216|Betaproteobacteria,1KSVJ@119069|Hydrogenophilales 28216|Betaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1260950_1 768670.Calni_0133 2.98e-30 122.0 COG4591@1|root,COG4591@2|Bacteria,2GEN3@200930|Deferribacteres 200930|Deferribacteres M MacB-like periplasmic core domain - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_1625082_1 998674.ATTE01000001_gene2846 5.91e-38 142.0 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,1RPJR@1236|Gammaproteobacteria 1236|Gammaproteobacteria P amino acid ABC transporter yhdY GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K02029,ko:K09971,ko:K10002,ko:K10037 ko02010,ko02020,map02010,map02020 M00227,M00230,M00232,M00236 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.18,3.A.1.3.19,3.A.1.3.2,3.A.1.3.4,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_214656_1 1029823.AFIE01000024_gene3369 1.61e-21 93.6 COG4339@1|root,COG4339@2|Bacteria,1MZ9X@1224|Proteobacteria,1S59I@1236|Gammaproteobacteria,3NIJ4@468|Moraxellaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - - k59_214660_1 237609.PSAKL28_22540 1.7e-35 138.0 COG1028@1|root,COG2030@1|root,COG1028@2|Bacteria,COG2030@2|Bacteria,1MXNQ@1224|Proteobacteria,1S0NX@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - MaoC_dehydratas,SCP2,adh_short k59_634182_1 1229909.NSED_08905 4.46e-33 114.0 arCOG02240@1|root,arCOG02240@2157|Archaea,41SSM@651137|Thaumarchaeota 651137|Thaumarchaeota S 4-oxalocrotonate tautomerase - - 5.3.2.6 ko:K01821 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 M00569 R03966,R05389 RC01040,RC01355 ko00000,ko00001,ko00002,ko01000 - - - Tautomerase k59_1155011_1 1347368.HG964406_gene6483 1.61e-06 55.1 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1TR2N@1239|Firmicutes,4H9RR@91061|Bacilli,1ZB2Q@1386|Bacillus 91061|Bacilli EU peptidase yuxL - 3.4.19.1 ko:K01303 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S9 k59_1050679_2 70601.3258419 7.06e-50 181.0 COG1155@1|root,arCOG03154@1|root,arCOG00868@2157|Archaea,arCOG03154@2157|Archaea,2XT8I@28890|Euryarchaeota,243AQ@183968|Thermococci 183968|Thermococci C Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn,Intein_splicing,LAGLIDADG_3 k59_1260968_1 1463820.JOGW01000005_gene3296 2.57e-72 234.0 COG3670@1|root,COG3670@2|Bacteria,2GK7D@201174|Actinobacteria 201174|Actinobacteria Q dioxygenase - - - - - - - - - - - - RPE65 k59_737072_2 258594.RPA0270 1.51e-38 143.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2TRZU@28211|Alphaproteobacteria,3JU6C@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria CH TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family ubiH GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663 - ko:K03185 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04989,R08773 RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_59595_1 644282.Deba_1963 3.82e-45 152.0 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,42SD2@68525|delta/epsilon subdivisions,2WP7H@28221|Deltaproteobacteria 28221|Deltaproteobacteria G PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 ptsN - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_1572577_2 876044.IMCC3088_2743 4.08e-24 99.0 COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,1S1Y6@1236|Gammaproteobacteria,1J5HR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase of the TIM-barrel fold - - - - - - - - - - - - Amidohydro_2 k59_1370807_1 768671.ThimaDRAFT_0203 7.29e-65 219.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1WXWN@135613|Chromatiales 135613|Chromatiales I PFAM 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_534864_1 1248916.ANFY01000007_gene2148 1.32e-42 155.0 COG0665@1|root,COG0665@2|Bacteria,1QWQF@1224|Proteobacteria,2VG40@28211|Alphaproteobacteria,2K9IP@204457|Sphingomonadales 204457|Sphingomonadales E NAD(P)-binding Rossmann-like domain - - - - - - - - - - - - NAD_binding_8 k59_430479_1 530564.Psta_4531 9.44e-51 174.0 COG0158@1|root,COG0158@2|Bacteria,2IWT3@203682|Planctomycetes 203682|Planctomycetes G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 fbp - 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase k59_116542_1 1380394.JADL01000005_gene5555 2.01e-217 615.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,2JRI6@204441|Rhodospirillales 204441|Rhodospirillales IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_800029_1 1121406.JAEX01000009_gene2665 8.05e-29 114.0 COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,42V1Y@68525|delta/epsilon subdivisions,2WRE9@28221|Deltaproteobacteria,2MC8Z@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function DUF45 - - - ko:K07043 - - - - ko00000 - - - DUF45 k59_1370817_2 1035195.HMPREF9997_01528 3.31e-07 55.5 COG0541@1|root,COG0541@2|Bacteria,2GK4R@201174|Actinobacteria,22M44@1653|Corynebacteriaceae 201174|Actinobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_378765_1 595537.Varpa_2256 6.33e-64 206.0 COG1028@1|root,COG1028@2|Bacteria,1MXFZ@1224|Proteobacteria,2VINF@28216|Betaproteobacteria,4AC6Y@80864|Comamonadaceae 28216|Betaproteobacteria IQ Short-chain dehydrogenase reductase sdr - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_900917_1 1211035.CD30_05860 2.41e-14 72.4 COG2820@1|root,COG2820@2|Bacteria,1TSEU@1239|Firmicutes,4HHWZ@91061|Bacilli 91061|Bacilli F Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis udp - 2.4.2.3 ko:K00757 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01876,R02484,R08229 RC00063 ko00000,ko00001,ko01000 - - - PNP_UDP_1 k59_68465_1 436308.Nmar_1740 1.03e-77 233.0 COG0652@1|root,arCOG04767@2157|Archaea,41T32@651137|Thaumarchaeota 651137|Thaumarchaeota O peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_378768_1 1075090.GOAMR_61_01100 7.25e-32 122.0 COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria,4GAGK@85026|Gordoniaceae 201174|Actinobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_378768_2 1445613.JALM01000042_gene1779 1.08e-46 164.0 COG1028@1|root,COG1028@2|Bacteria,2I8GX@201174|Actinobacteria,4DX51@85010|Pseudonocardiales 201174|Actinobacteria IQ NAD dependent epimerase/dehydratase family - - - - - - - - - - - - adh_short,adh_short_C2 k59_326773_2 436308.Nmar_0299 5.31e-162 467.0 COG0036@1|root,COG3959@1|root,arCOG01053@2157|Archaea,arCOG05046@2157|Archaea,41SBE@651137|Thaumarchaeota 651137|Thaumarchaeota G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim,Transketolase_N k59_800069_1 1188252.AJYK01000027_gene523 6.69e-69 218.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1RNQ4@1236|Gammaproteobacteria,1XSME@135623|Vibrionales 135623|Vibrionales C Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily frmA - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_378796_1 1160137.KB907307_gene4136 2.56e-22 97.8 COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4FTZG@85025|Nocardiaceae 201174|Actinobacteria I Acyl-CoA dehydrogenase, N-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_378796_2 247634.GPB2148_2885 1.28e-19 88.6 COG1960@1|root,COG1960@2|Bacteria,1R3VD@1224|Proteobacteria,1SM1B@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_5781_1 228410.NE1034 3.4e-44 145.0 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2VSHX@28216|Betaproteobacteria,3735G@32003|Nitrosomonadales 28216|Betaproteobacteria O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_1317609_1 1459636.NTE_03510 1.81e-44 157.0 COG0861@1|root,arCOG09430@2157|Archaea 2157|Archaea P PFAM Integral membrane protein TerC - - - ko:K05794 - - - - ko00000 - - - TerC k59_1317609_2 1158318.ATXC01000002_gene1546 0.000644 43.5 COG0589@1|root,COG0589@2|Bacteria 2|Bacteria T AMP binding - - - - - - - - - - - - SpoIIAA-like,Usp k59_1579255_1 572477.Alvin_3056 2.01e-60 193.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1WXKR@135613|Chromatiales 135613|Chromatiales NU Pilus assembly protein PilO - - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_116618_1 313624.NSP_17070 7.97e-23 98.6 COG4422@1|root,COG4422@2|Bacteria,1G1Q2@1117|Cyanobacteria,1HNB4@1161|Nostocales 1117|Cyanobacteria S Phage Gp37Gp68 family protein - - - - - - - - - - - - DUF5131 k59_326804_1 666685.R2APBS1_2291 1.09e-118 345.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1X45V@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the KdsA family kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_326804_2 83406.HDN1F_28570 4.66e-08 53.9 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1J4XM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_3323,iPC815.YPO3377 CTP_synth_N,GATase k59_1216619_1 861299.J421_2803 1.56e-29 114.0 COG2805@1|root,COG2805@2|Bacteria,1ZT2Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1216619_2 1347086.CCBA010000006_gene4689 4.08e-13 71.2 COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,4H9PH@91061|Bacilli,1ZDB3@1386|Bacillus 91061|Bacilli E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - iYO844.BSU23070 2-Hacid_dh,2-Hacid_dh_C,ACT k59_484272_1 1192034.CAP_2432 4.9e-66 214.0 COG0303@1|root,COG0303@2|Bacteria 2|Bacteria H 'Molybdopterin - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_378833_2 1121937.AUHJ01000005_gene2270 5.01e-45 156.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,1RQ1X@1236|Gammaproteobacteria,46CKZ@72275|Alteromonadaceae 1236|Gammaproteobacteria C Aldo/keto reductase family mocA - - - - - - - - - - - Aldo_ket_red k59_587267_1 751994.AGIG01000009_gene1056 1.87e-58 187.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1J4Y5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_587267_2 232346.JHQL01000005_gene3289 5.11e-21 88.6 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1XJFF@135619|Oceanospirillales 135619|Oceanospirillales J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_1632415_1 1128421.JAGA01000002_gene1834 2e-112 354.0 COG0178@1|root,COG0178@2|Bacteria,2NNT3@2323|unclassified Bacteria 2|Bacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_68538_1 991905.SL003B_3376 3.36e-61 207.0 COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,2TR6C@28211|Alphaproteobacteria,4BRF5@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_1317624_1 1238182.C882_3070 2.92e-16 86.3 COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,2TTU7@28211|Alphaproteobacteria,2JQHE@204441|Rhodospirillales 204441|Rhodospirillales S Peptidase family M48 - - - - - - - - - - - - LysM,Peptidase_M48 k59_952482_1 1218084.BBJK01000115_gene6776 2.62e-43 155.0 COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,2VKI0@28216|Betaproteobacteria,1K199@119060|Burkholderiaceae 28216|Betaproteobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_167424_1 157783.LK03_10250 3.43e-28 108.0 COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1SEQD@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase III chi subunit holC - 2.7.7.7 ko:K02339 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_chi k59_116638_1 1403819.BATR01000104_gene3620 7.4e-59 196.0 COG0141@1|root,COG0141@2|Bacteria,46SHG@74201|Verrucomicrobia,2ITG9@203494|Verrucomicrobiae 203494|Verrucomicrobiae E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_1057690_1 747365.Thena_0956 2.08e-17 81.6 COG0461@1|root,COG0461@2|Bacteria,1W78Q@1239|Firmicutes,25M0Y@186801|Clostridia,42IM8@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_484286_1 261292.Nit79A3_2959 4.59e-41 150.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,372QB@32003|Nitrosomonadales 28216|Betaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_484286_2 857087.Metme_2164 1.99e-33 128.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1XE19@135618|Methylococcales 135618|Methylococcales T PFAM PhoH-like protein - - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_68543_1 1187851.A33M_4208 2.3e-110 332.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,3FCY5@34008|Rhodovulum 28211|Alphaproteobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2 k59_534927_1 521674.Plim_1622 1.49e-17 80.5 COG1215@1|root,COG1215@2|Bacteria,2IXXE@203682|Planctomycetes 203682|Planctomycetes M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_534927_2 502025.Hoch_2507 9.36e-10 62.4 COG3119@1|root,COG3119@2|Bacteria,1QZHU@1224|Proteobacteria,42PUM@68525|delta/epsilon subdivisions,2X7T5@28221|Deltaproteobacteria,2Z00V@29|Myxococcales 28221|Deltaproteobacteria P Sulfatase - - 3.1.6.6 ko:K01133 - - - - ko00000,ko01000 - - - Cu-binding_MopE,Sulfatase k59_643229_1 1286106.MPL1_01204 2.26e-109 322.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,4603P@72273|Thiotrichales 72273|Thiotrichales E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_1317630_2 1027273.GZ77_17910 1.16e-74 234.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1XI8U@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_1579289_2 177439.DP1881 8.76e-77 239.0 COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,42MJ3@68525|delta/epsilon subdivisions,2WKD5@28221|Deltaproteobacteria,2MHQC@213118|Desulfobacterales 28221|Deltaproteobacteria P PBP superfamily domain - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_1477910_1 398578.Daci_3709 2.58e-12 66.2 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2VHNY@28216|Betaproteobacteria,4AB1R@80864|Comamonadaceae 28216|Betaproteobacteria S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis yggS - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_1477910_2 330214.NIDE0770 1.24e-68 217.0 COG0345@1|root,COG0345@2|Bacteria,3J0N8@40117|Nitrospirae 40117|Nitrospirae E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_378868_1 472759.Nhal_3709 3.01e-119 371.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1WVW8@135613|Chromatiales 135613|Chromatiales EF Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_1370873_1 62928.azo1951 4.06e-63 229.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2VJ61@28216|Betaproteobacteria,2KUQ8@206389|Rhodocyclales 206389|Rhodocyclales S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_326834_1 216594.MMAR_4749 2.28e-32 124.0 COG1960@1|root,COG1960@2|Bacteria,2GM6Q@201174|Actinobacteria,236IZ@1762|Mycobacteriaceae 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1 k59_378879_1 330214.NIDE1738 4.32e-92 282.0 COG1893@1|root,COG2041@1|root,COG1893@2|Bacteria,COG2041@2|Bacteria,3J0S5@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_1632438_1 243233.MCA2847 9.33e-13 73.2 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1XEIM@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_1477926_2 425104.Ssed_2273 2.75e-104 335.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1149@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1149@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,2QA4T@267890|Shewanellaceae 1236|Gammaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1269951_1 1205680.CAKO01000002_gene2843 6.04e-63 202.0 COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,2TRJT@28211|Alphaproteobacteria,2JSBT@204441|Rhodospirillales 204441|Rhodospirillales S Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - ko:K15777 ko00965,map00965 - R08836 RC00387 ko00000,ko00001,ko01000 - - - LigB k59_1057712_1 365528.KB891208_gene2910 8.17e-05 45.1 COG4221@1|root,COG4221@2|Bacteria,2GKK7@201174|Actinobacteria 201174|Actinobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1057712_2 105420.BBPO01000026_gene7086 7.6e-42 142.0 COG5517@1|root,COG5517@2|Bacteria,2IFNT@201174|Actinobacteria,2NIVV@228398|Streptacidiphilus 201174|Actinobacteria Q SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_901645_1 944479.JQLX01000012_gene1122 1.5e-05 49.3 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WJYB@28221|Deltaproteobacteria,2M6SS@213113|Desulfurellales 28221|Deltaproteobacteria NU Tfp pilus assembly protein tip-associated adhesin - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_1579994_1 298655.KI912267_gene7654 4.41e-51 170.0 COG1028@1|root,COG1028@2|Bacteria,2GNUM@201174|Actinobacteria,4EU5K@85013|Frankiales 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short,adh_short_C2 k59_644254_1 1229909.NSED_05115 2.65e-118 346.0 COG0547@1|root,arCOG02012@2157|Archaea,41SGG@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_644254_2 1229909.NSED_05120 1.34e-11 63.2 COG0134@1|root,arCOG01088@2157|Archaea,41SN7@651137|Thaumarchaeota 651137|Thaumarchaeota E Indole-3-glycerol phosphate synthase - - 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS k59_587953_1 1380347.JNII01000008_gene4422 1.15e-47 171.0 COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4EUAJ@85013|Frankiales 201174|Actinobacteria Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_1371565_1 96561.Dole_3203 1.13e-119 355.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MDC@68525|delta/epsilon subdivisions,2WJM7@28221|Deltaproteobacteria,2MHWR@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the DegT DnrJ EryC1 family - - 2.6.1.102,2.6.1.109 ko:K13010,ko:K19715 ko00520,map00520 - R10460,R11395 RC00006,RC00160,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k59_953180_1 706587.Desti_4172 1.3e-75 240.0 COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,42PX0@68525|delta/epsilon subdivisions,2WJUG@28221|Deltaproteobacteria,2MQYT@213462|Syntrophobacterales 28221|Deltaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - 2.4.1.266 ko:K13693 - - - - ko00000,ko01000,ko01003 - GT81 - - k59_1005541_1 1454202.PPBDW_110086___1 2.61e-05 45.4 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1XVP9@135623|Vibrionales 135623|Vibrionales D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_1005541_2 335659.S23_17230 4.63e-05 52.0 COG1589@1|root,COG1589@2|Bacteria,1MY1Q@1224|Proteobacteria,2TQPU@28211|Alphaproteobacteria,3JTKK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria D Essential cell division protein ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_535581_1 525897.Dbac_3070 7.86e-32 125.0 COG1450@1|root,COG1450@2|Bacteria,1NC06@1224|Proteobacteria 1224|Proteobacteria NU Type ii and iii secretion system protein - - - - - - - - - - - - Secretin,Secretin_N k59_1425416_1 1120983.KB894572_gene3230 7.3e-29 116.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2TS4C@28211|Alphaproteobacteria,1JN96@119043|Rhodobiaceae 28211|Alphaproteobacteria L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_587964_1 237609.PSAKL28_27540 1.44e-39 150.0 COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria 1224|Proteobacteria Q Multicopper oxidase - - 1.16.3.3 ko:K22349 - - - - ko00000,ko01000 - - - - k59_485461_2 1419583.V466_18560 2.47e-28 116.0 COG0760@1|root,COG0760@2|Bacteria,1PK25@1224|Proteobacteria,1RUZ1@1236|Gammaproteobacteria,1YSR6@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria M SurA N-terminal domain - - - - - - - - - - - - Rotamase,SurA_N_3 k59_69643_1 1280941.HY2_15200 6.8e-58 191.0 COG1960@1|root,COG1960@2|Bacteria,1R7HF@1224|Proteobacteria,2U3BJ@28211|Alphaproteobacteria,43ZJ8@69657|Hyphomonadaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_431098_1 1121090.KB894699_gene4166 6.13e-41 150.0 COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,1ZB90@1386|Bacillus 91061|Bacilli EGP COG0477 Permeases of the major facilitator superfamily tetA_3 - - - - - - - - - - - MFS_1,MFS_1_like,Sugar_tr k59_1633126_1 1336237.JAEE01000009_gene426 1.39e-66 208.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1RP9U@1236|Gammaproteobacteria 1236|Gammaproteobacteria M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiA GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K01802,ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_1228040_1 1379281.AVAG01000065_gene1155 1.51e-64 219.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2WJ3E@28221|Deltaproteobacteria,2M9Q4@213115|Desulfovibrionales 28221|Deltaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iAF987.Gmet_2300 Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_1014939_2 926569.ANT_22810 2.98e-119 347.0 COG0588@1|root,COG0588@2|Bacteria,2G822@200795|Chloroflexi 200795|Chloroflexi G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmA - 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_656510_1 565045.NOR51B_127 2.03e-39 148.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1J50B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_1380371_1 1458357.BG58_37610 3.86e-21 91.7 2C585@1|root,32RF8@2|Bacteria,1RHNI@1224|Proteobacteria,2WAZB@28216|Betaproteobacteria,1K4NE@119060|Burkholderiaceae 28216|Betaproteobacteria G Belongs to the queuine tRNA-ribosyltransferase family - - - - - - - - - - - - TGT k59_1380371_2 765911.Thivi_2275 2.38e-37 134.0 COG0590@1|root,COG2154@1|root,COG0590@2|Bacteria,COG2154@2|Bacteria,1RGU0@1224|Proteobacteria,1S60Z@1236|Gammaproteobacteria,1WXZ8@135613|Chromatiales 135613|Chromatiales FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam k59_1325022_1 1191523.MROS_0169 5.41e-75 234.0 COG0714@1|root,COG0714@2|Bacteria 2|Bacteria KLT Associated with various cellular activities moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_81821_2 113395.AXAI01000005_gene3906 3.42e-33 120.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2U797@28211|Alphaproteobacteria,3JTAJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.31,3.5.1.88 ko:K01450,ko:K01462 ko00270,ko00630,map00270,map00630 - R00653 RC00165,RC00323 ko00000,ko00001,ko01000 - - - Pep_deformylase k59_128987_1 1469245.JFBG01000011_gene815 1.19e-88 268.0 COG2872@1|root,COG2872@2|Bacteria,1MY0P@1224|Proteobacteria,1S3RR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Threonyl and Alanyl tRNA synthetase second additional domain - - - ko:K07050 - - - - ko00000,ko01000,ko03016 - - - tRNA-synt_2c,tRNA_SAD k59_1589514_1 472759.Nhal_0351 1.19e-87 273.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1WX79@135613|Chromatiales 135613|Chromatiales E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_1491183_1 402881.Plav_1028 2.23e-71 223.0 COG1024@1|root,COG1024@2|Bacteria,1PK10@1224|Proteobacteria,2TS4M@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - - - - - - - - - - - ECH_1 k59_1530515_1 1141136.K4F9K8_9CAUD 2.66e-24 108.0 4QAKZ@10239|Viruses,4QVQ3@35237|dsDNA viruses no RNA stage,4QPYH@28883|Caudovirales,4QIYN@10662|Myoviridae 10662|Myoviridae S exonuclease activity - - - - - - - - - - - - - k59_1437406_1 555217.Zmob_1380 4.21e-42 148.0 COG0598@1|root,COG0598@2|Bacteria,1MW8W@1224|Proteobacteria,2U2S4@28211|Alphaproteobacteria,2K1TZ@204457|Sphingomonadales 204457|Sphingomonadales P Mg2 transporter protein, CorA family protein - - - ko:K16074 - - - - ko00000,ko02000 1.A.35.4 - - CorA k59_1491189_1 1123399.AQVE01000022_gene338 3.11e-28 111.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,462CR@72273|Thiotrichales 72273|Thiotrichales S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 k59_858697_1 1201288.M900_1606 1.54e-31 121.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,42MXJ@68525|delta/epsilon subdivisions,2WKAC@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Alcohol dehydrogenase zinc-binding domain protein acuI - - ko:K19745 ko00640,ko01100,map00640,map01100 - R00919 RC00095 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_441790_1 1174528.JH992893_gene5843 5.75e-57 187.0 COG0111@1|root,COG0111@2|Bacteria,1FZZU@1117|Cyanobacteria 1117|Cyanobacteria E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_441790_2 765913.ThidrDRAFT_3979 1.98e-112 334.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,1WW4Q@135613|Chromatiales 135613|Chromatiales CH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_497756_1 1163617.SCD_n00628 5.94e-97 288.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2VHSD@28216|Betaproteobacteria 28216|Betaproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_962156_1 472759.Nhal_1306 2.03e-22 97.1 COG1213@1|root,COG2513@1|root,COG1213@2|Bacteria,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,1RY5Q@1236|Gammaproteobacteria,1X09Q@135613|Chromatiales 135613|Chromatiales C Phosphoenolpyruvate phosphomutase - - 5.4.2.9 ko:K01841 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 - R00661 RC02792 ko00000,ko00001,ko01000 - - - NTP_transf_3,PEP_mutase k59_962156_2 1218075.BAYA01000030_gene5900 2.44e-40 144.0 COG0028@1|root,COG4032@1|root,COG0028@2|Bacteria,COG4032@2|Bacteria,1R6QP@1224|Proteobacteria,2VQ61@28216|Betaproteobacteria,1KFK9@119060|Burkholderiaceae 28216|Betaproteobacteria EH Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - 4.1.1.82 ko:K09459 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 - R04053 RC00506 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_N k59_1119756_1 177439.DP0751 9.58e-31 111.0 COG1522@1|root,COG1522@2|Bacteria,1NC1H@1224|Proteobacteria,42XZS@68525|delta/epsilon subdivisions,2WSXJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Lrp/AsnC ligand binding domain - - - - - - - - - - - - AsnC_trans_reg k59_1437443_1 397945.Aave_4518 6.62e-62 207.0 COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,2VHTR@28216|Betaproteobacteria,4AB3G@80864|Comamonadaceae 28216|Betaproteobacteria S Deoxyribodipyrimidine photo-lyase-related protein - - - ko:K06876 - - - - ko00000 - - - DPRP k59_497767_1 1380394.JADL01000008_gene3523 2.13e-88 265.0 COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,2TSX7@28211|Alphaproteobacteria,2JRUR@204441|Rhodospirillales 204441|Rhodospirillales G Class II Aldolase and Adducin N-terminal domain - - 4.1.1.104 ko:K22130 - - - - ko00000,ko01000 - - - Aldolase_II k59_497767_2 1411123.JQNH01000001_gene2071 4.54e-102 305.0 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.1.1.41,4.2.1.17 ko:K01692,ko:K11264 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R00923,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00097,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_497767_3 1278309.KB907099_gene3031 1.22e-53 174.0 COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,1S6S0@1236|Gammaproteobacteria,1XK46@135619|Oceanospirillales 135619|Oceanospirillales S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily ybaK - - ko:K03976 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_497767_4 1380394.JADL01000009_gene3253 3.15e-21 91.3 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2U5PC@28211|Alphaproteobacteria,2JX5S@204441|Rhodospirillales 204441|Rhodospirillales EH Amino-transferase class IV - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_231463_1 1274.HX89_09325 1.49e-36 140.0 COG0370@1|root,COG0370@2|Bacteria,2GTV2@201174|Actinobacteria 201174|Actinobacteria P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoA,FeoB_C,FeoB_N,Gate k59_441811_1 28042.GU90_18665 1.21e-59 202.0 COG2072@1|root,COG2072@2|Bacteria,2GJEA@201174|Actinobacteria,4E05U@85010|Pseudonocardiales 201174|Actinobacteria P flavoprotein involved in K transport - - - - - - - - - - - - FMO-like,K_oxygenase,Pyr_redox_3 k59_1168686_1 247490.KSU1_D0999 1.27e-21 99.0 COG1409@1|root,COG3204@1|root,COG1409@2|Bacteria,COG3204@2|Bacteria,2IYSB@203682|Planctomycetes 203682|Planctomycetes G Purple acid Phosphatase, N-terminal domain - - - - - - - - - - - - Metallophos,Pur_ac_phosph_N k59_1119769_1 56780.SYN_01954 2.86e-34 131.0 COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,42RUN@68525|delta/epsilon subdivisions,2WNJZ@28221|Deltaproteobacteria,2MR4S@213462|Syntrophobacterales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - CHASE4,HAMP,HATPase_c,HisKA_3,PAS_3,PAS_4,PAS_9 k59_1119769_2 401053.AciPR4_0836 1.56e-18 85.5 COG2197@1|root,COG2197@2|Bacteria,3Y2WY@57723|Acidobacteria,2JIR0@204432|Acidobacteriia 204432|Acidobacteriia K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_1590602_1 1088721.NSU_3664 3.11e-52 178.0 COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Flavoprotein involved in K transport - - - ko:K07222 - - - - ko00000 - - - Pyr_redox_3 k59_545448_1 760117.JN27_01680 5.96e-14 75.5 COG4094@1|root,COG4094@2|Bacteria,1RDF9@1224|Proteobacteria 1224|Proteobacteria S NnrU protein - - - - - - - - - - - - NnrU k59_912210_1 566466.NOR53_3686 4.29e-97 295.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,1RQ3D@1236|Gammaproteobacteria,1JA8Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG1541 Coenzyme F390 synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C_2 k59_598255_1 1454202.PPBDW_130375___1 5.62e-41 137.0 COG2329@1|root,COG2329@2|Bacteria,1MZKW@1224|Proteobacteria,1S9N8@1236|Gammaproteobacteria,1XXP3@135623|Vibrionales 135623|Vibrionales S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_1381254_2 1249627.D779_1248 7.89e-17 73.6 COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,1SC7M@1236|Gammaproteobacteria,1WZTU@135613|Chromatiales 135613|Chromatiales S Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase yacG - - ko:K09862 - - - - ko00000 - - - YacG k59_285430_1 314231.FP2506_10911 1.55e-69 236.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,2PJ2U@255475|Aurantimonadaceae 28211|Alphaproteobacteria E GXGXG motif gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_285430_2 998674.ATTE01000001_gene4336 3.26e-33 125.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,45ZPY@72273|Thiotrichales 72273|Thiotrichales E Glutamate synthase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_232462_1 926550.CLDAP_03450 1.82e-50 181.0 COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2G65W@200795|Chloroflexi 200795|Chloroflexi M PFAM transferase hexapeptide repeat containing protein - - 2.7.7.13,5.4.2.8 ko:K16881 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114,M00362 R00885,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III k59_657955_1 1122238.AULR01000002_gene481 9.5e-30 123.0 COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4FKJ5@85023|Microbacteriaceae 201174|Actinobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_499160_1 644282.Deba_3133 1.15e-80 266.0 COG1028@1|root,COG1545@1|root,COG3255@1|root,COG3425@1|root,COG1028@2|Bacteria,COG1545@2|Bacteria,COG3255@2|Bacteria,COG3425@2|Bacteria,1MXNQ@1224|Proteobacteria 1224|Proteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family MA20_27450 - - - - - - - - - - - adh_short k59_1438808_1 67373.JOBF01000025_gene7043 1.19e-81 263.0 COG0318@1|root,COG0318@2|Bacteria,2GMVB@201174|Actinobacteria 201174|Actinobacteria IQ Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_130364_1 595537.Varpa_2706 8.37e-24 97.8 COG0500@1|root,COG2226@2|Bacteria,1MVXG@1224|Proteobacteria,2VM9F@28216|Betaproteobacteria,4ADEU@80864|Comamonadaceae 28216|Betaproteobacteria H ubiE/COQ5 methyltransferase family - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_443115_2 445696.E3ST09_9CAUD 1.01e-59 186.0 4QAQV@10239|Viruses,4QUPK@35237|dsDNA viruses no RNA stage,4QPCB@28883|Caudovirales,4QHX6@10662|Myoviridae 10662|Myoviridae S hydrolase activity - - - - - - - - - - - - - k59_1229457_1 98439.AJLL01000071_gene1292 5.64e-16 71.6 COG3450@1|root,COG3450@2|Bacteria,1G7YR@1117|Cyanobacteria,1JIVK@1189|Stigonemataceae 1117|Cyanobacteria S Ethanolamine utilisation protein EutQ - - - ko:K06995 - - - - ko00000 - - - Cupin_3 k59_1229457_2 444860.E3SJ16_9CAUD 3.95e-96 280.0 4QE8Y@10239|Viruses,4QW3S@35237|dsDNA viruses no RNA stage,4QPGZ@28883|Caudovirales,4QISX@10662|Myoviridae 10662|Myoviridae S Recombination, repair and ssDNA binding protein UvsY - - - - - - - - - - - - - k59_1229457_3 444860.E3SJ15_9CAUD 3.88e-30 111.0 4QAQQ@10239|Viruses,4QVZX@35237|dsDNA viruses no RNA stage,4QPBX@28883|Caudovirales,4QIBM@10662|Myoviridae 10662|Myoviridae S T4-like virus tail tube protein gp19 - - - - - - - - - - - - - k59_1381271_1 1095769.CAHF01000014_gene2954 2.12e-57 199.0 COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,2VKA1@28216|Betaproteobacteria,4732I@75682|Oxalobacteraceae 28216|Betaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_815058_1 1487923.DP73_09905 1.79e-60 201.0 COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia,2607C@186807|Peptococcaceae 186801|Clostridia C PFAM CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1531400_1 1163617.SCD_n01285 2.77e-32 130.0 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria 28216|Betaproteobacteria E PFAM transglutaminase domain protein - - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_83267_2 713586.KB900536_gene638 1.39e-55 181.0 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria,1WX9X@135613|Chromatiales 135613|Chromatiales O PFAM Peptidase M22, glycoprotease - - - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 k59_1285031_1 298386.PBPRA0434 1.09e-91 278.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1XSZ3@135623|Vibrionales 135623|Vibrionales J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_657987_1 157072.XP_008881144.1 1.06e-44 167.0 COG0265@1|root,KOG1421@2759|Eukaryota 2759|Eukaryota O serine-type endopeptidase activity NMA111 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0006629,GO:0006807,GO:0006915,GO:0006950,GO:0008150,GO:0008152,GO:0008219,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009416,GO:0009507,GO:0009536,GO:0009628,GO:0009642,GO:0009644,GO:0009892,GO:0009987,GO:0010109,GO:0010205,GO:0012501,GO:0016787,GO:0017171,GO:0019222,GO:0019538,GO:0030163,GO:0031323,GO:0031324,GO:0033554,GO:0034605,GO:0042548,GO:0043155,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043467,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051603,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1905156 - - - - - - - - - - PDZ,PDZ_1,PDZ_2,Trypsin_2 k59_545482_1 396588.Tgr7_0539 1.01e-67 212.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1RMSA@1236|Gammaproteobacteria,1X07Q@135613|Chromatiales 135613|Chromatiales U PFAM MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_545482_2 864051.BurJ1DRAFT_1737 3.86e-34 124.0 COG0848@1|root,COG0848@2|Bacteria,1RHI8@1224|Proteobacteria,2W2ZB@28216|Betaproteobacteria,1KNMZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria U Biopolymer transport protein ExbD/TolR - - - - - - - - - - - - ExbD k59_815072_1 68199.JNZO01000023_gene1864 3.4e-12 69.3 COG1136@1|root,COG1136@2|Bacteria,2GNJ1@201174|Actinobacteria 201174|Actinobacteria V ABC transporter, ATP-binding protein - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1590647_1 86106.I862_05675 4.36e-106 327.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2TQRS@28211|Alphaproteobacteria,47EVC@766|Rickettsiales 766|Rickettsiales F Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c_3,HSP90 k59_1016092_1 203124.Tery_3562 4.11e-16 76.3 COG0778@1|root,COG0778@2|Bacteria,1G42X@1117|Cyanobacteria,1HFEV@1150|Oscillatoriales 1117|Cyanobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_1016092_2 472759.Nhal_2693 1e-21 89.7 COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,1WYI6@135613|Chromatiales 135613|Chromatiales J Belongs to the HSP15 family - - - ko:K04762 - - - - ko00000,ko03110 - - - S4 k59_232496_1 639030.JHVA01000001_gene1053 2.35e-16 78.2 COG2353@1|root,COG2353@2|Bacteria,3Y5DX@57723|Acidobacteria,2JJP6@204432|Acidobacteriia 204432|Acidobacteriia S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_598305_1 861299.J421_4071 7.3e-114 346.0 COG1574@1|root,COG1574@2|Bacteria,1ZTC9@142182|Gemmatimonadetes 2|Bacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_1531418_1 1122194.AUHU01000005_gene1085 1.92e-36 134.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,464UF@72275|Alteromonadaceae 1236|Gammaproteobacteria E chorismate mutase pheA - 4.2.1.51,5.4.99.5 ko:K04518,ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_1531418_2 1131553.JIBI01000012_gene817 9.83e-54 181.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2VIHG@28216|Betaproteobacteria,371V7@32003|Nitrosomonadales 28216|Betaproteobacteria C D-isomer specific 2-hydroxyacid dehydrogenase serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_1120884_1 331869.BAL199_08533 1.29e-48 156.0 COG2721@1|root,COG2721@2|Bacteria,1MZBN@1224|Proteobacteria,2UC3F@28211|Alphaproteobacteria,4BSTE@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G SAF domain - - 4.4.1.24 ko:K16845 ko00270,map00270 - R07633 RC01785 ko00000,ko00001,ko01000 - - - SAF k59_1120884_2 1411123.JQNH01000001_gene2677 1.28e-86 266.0 COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2TTDT@28211|Alphaproteobacteria 28211|Alphaproteobacteria G D-galactarate dehydratase Altronate hydrolase garD - 4.2.1.7,4.4.1.24 ko:K16846,ko:K16850 ko00040,ko00270,ko01100,map00040,map00270,map01100 M00631 R01540,R07633 RC00543,RC01785 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C k59_1325963_1 1205680.CAKO01000002_gene2220 9.14e-46 150.0 2BRR9@1|root,32KR1@2|Bacteria,1P9A5@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1325963_2 1205680.CAKO01000002_gene2221 1.21e-34 122.0 2DBSD@1|root,2ZARI@2|Bacteria,1MX0F@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_11123_1 1282361.ABAC402_10725 4.08e-19 92.8 COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2TUZZ@28211|Alphaproteobacteria,2KFCI@204458|Caulobacterales 204458|Caulobacterales E Prolyl oligopeptidase - - - - - - - - - - - - Peptidase_S9 k59_1657393_1 754476.Q7A_1355 5.45e-84 256.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,460GM@72273|Thiotrichales 72273|Thiotrichales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_453661_1 5180.EDO01003 2.79e-58 205.0 COG1003@1|root,KOG2040@2759|Eukaryota,38E0D@33154|Opisthokonta,3NWQC@4751|Fungi,3QJE3@4890|Ascomycota,20W75@147548|Leotiomycetes 4751|Fungi E The glycine cleavage system catalyzes the degradation of glycine GCV2 GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006730,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 1.4.4.2 ko:K00281 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P k59_183854_1 1028803.GG9_0980 0.000632 46.2 COG0790@1|root,COG0790@2|Bacteria 2|Bacteria S beta-lactamase activity ybeQ GO:0006950,GO:0006979,GO:0008150,GO:0050896 - ko:K07126 - - - - ko00000 - - - Sel1 k59_1177295_1 349521.HCH_04046 7.38e-104 318.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RR0R@1236|Gammaproteobacteria,1XN85@135619|Oceanospirillales 135619|Oceanospirillales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,Peptidase_M41 k59_1657396_1 1394176.AWUO01000002_gene1618 5.31e-23 106.0 COG3291@1|root,COG5184@1|root,COG3291@2|Bacteria,COG5184@2|Bacteria,2IDH9@201174|Actinobacteria,4D0CR@85004|Bifidobacteriales 201174|Actinobacteria M Listeria-Bacteroides repeat domain (List_Bact_rpt) - - - - - - - - - - - - Flg_new,RCC1,RCC1_2 k59_553907_1 998674.ATTE01000001_gene2427 1.4e-41 142.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,1RPK3@1236|Gammaproteobacteria,460KW@72273|Thiotrichales 72273|Thiotrichales J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_1296504_1 1123508.JH636440_gene2904 1.03e-41 156.0 COG5002@1|root,COG5002@2|Bacteria,2IXHW@203682|Planctomycetes 203682|Planctomycetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_9 k59_183863_1 330214.NIDE0608 5.48e-101 302.0 COG1005@1|root,COG1005@2|Bacteria,3J0E2@40117|Nitrospirae 40117|Nitrospirae C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_867717_1 1194972.MVAC_11832 7.23e-15 77.0 COG1920@1|root,COG1920@2|Bacteria,2HJNU@201174|Actinobacteria,233J8@1762|Mycobacteriaceae 201174|Actinobacteria H Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor cofC GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568 2.7.7.68 ko:K14941 ko00680,ko01120,map00680,map01120 M00378 R09397 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CofC,NTP_transf_3 k59_1538717_1 247633.GP2143_10112 2.92e-24 98.6 COG0776@1|root,COG0776@2|Bacteria,1RFWH@1224|Proteobacteria,1S5GE@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the bacterial histone-like protein family VL23_14575 - - - - - - - - - - - Bac_DNA_binding k59_1334531_1 472759.Nhal_0715 8.77e-11 63.2 COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,1RNF3@1236|Gammaproteobacteria,1WWVY@135613|Chromatiales 135613|Chromatiales T PFAM MucB RseB - - - ko:K03598 - - - - ko00000,ko03021 - - - MucB_RseB,MucB_RseB_C k59_1334531_2 519989.ECTPHS_08343 2.73e-05 46.6 COG3086@1|root,COG3086@2|Bacteria,1N6QS@1224|Proteobacteria,1SCTM@1236|Gammaproteobacteria,1WYRU@135613|Chromatiales 135613|Chromatiales T PFAM Positive regulator of sigma(E), RseC MucC - - - ko:K03803 - - - - ko00000,ko03021 - - - RseC_MucC k59_868884_1 1229205.BUPH_06588 4.62e-32 117.0 COG5588@1|root,COG5588@2|Bacteria,1RGIE@1224|Proteobacteria,2VNWW@28216|Betaproteobacteria,1KHHM@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1326) - - - - - - - - - - - - DUF1326 k59_868884_2 211165.AJLN01000116_gene3204 7.78e-08 57.8 COG5486@1|root,COG5486@2|Bacteria,1GF5E@1117|Cyanobacteria 1117|Cyanobacteria S Predicted metal-binding integral membrane protein (DUF2182) - - - - - - - - - - - - DUF2182 k59_1241088_1 1379270.AUXF01000001_gene2140 2.19e-91 300.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1ZUC7@142182|Gemmatimonadetes 142182|Gemmatimonadetes QU Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,PD40 k59_1599333_1 887929.HMP0721_1506 3.59e-15 72.0 COG0091@1|root,COG0091@2|Bacteria,1V6PU@1239|Firmicutes,24JF4@186801|Clostridia,25WWP@186806|Eubacteriaceae 186801|Clostridia J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_1599333_2 1123371.ATXH01000034_gene791 7.87e-36 124.0 COG0185@1|root,COG0185@2|Bacteria,2GHZ4@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_1599333_3 1267534.KB906757_gene818 1.5e-80 248.0 COG0090@1|root,COG0090@2|Bacteria,3Y3DH@57723|Acidobacteria,2JI2K@204432|Acidobacteriia 204432|Acidobacteriia J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_1659177_1 880072.Desac_0280 1.72e-17 84.0 COG0517@1|root,COG0517@2|Bacteria,1RA25@1224|Proteobacteria,42R80@68525|delta/epsilon subdivisions,2WMW6@28221|Deltaproteobacteria,2MRHW@213462|Syntrophobacterales 28221|Deltaproteobacteria S PFAM CBS domain - - - ko:K04767 - - - - ko00000 - - - CBS k59_1659177_2 436308.Nmar_1665 1.33e-66 207.0 COG3794@1|root,arCOG02926@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind,Cupredoxin_1 k59_297085_1 323848.Nmul_A0901 1.95e-70 232.0 COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,2VJIQ@28216|Betaproteobacteria,372GH@32003|Nitrosomonadales 28216|Betaproteobacteria L DNA polymerase X family - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP k59_1080727_2 566466.NOR53_3573 6.65e-20 87.0 COG1024@1|root,COG1024@2|Bacteria,1RAAV@1224|Proteobacteria,1SK2I@1236|Gammaproteobacteria,1J9RM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_1505893_1 394221.Mmar10_0178 1.01e-86 282.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,43WSR@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_1178358_2 1229909.NSED_08220 5.28e-45 150.0 COG1986@1|root,arCOG01223@2157|Archaea,41SKV@651137|Thaumarchaeota 651137|Thaumarchaeota H Cytidylyltransferase-like - - 2.7.7.3 ko:K02201 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_1241098_2 466088.CL42_05460 7.88e-21 91.7 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,1RNXH@1236|Gammaproteobacteria,3NIX3@468|Moraxellaceae 1236|Gammaproteobacteria C Aldo/keto reductase family tas GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016491,GO:0016614,GO:0016616,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:1990928 - - - - - - - - - - Aldo_ket_red k59_1132791_1 1229909.NSED_03690 7.3e-75 225.0 COG1310@1|root,arCOG01139@2157|Archaea,41SQ7@651137|Thaumarchaeota 651137|Thaumarchaeota S metal-dependent protease of the PAD1 JAB1 superfamily - - - - - - - - - - - - Prok-JAB k59_1659201_1 1207075.PputUW4_01557 4.2e-78 247.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,1RQVT@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_1080746_1 1198452.Jab_2c30700 4.47e-05 45.8 COG1309@1|root,COG1309@2|Bacteria,1R59A@1224|Proteobacteria,2VRE6@28216|Betaproteobacteria,476D0@75682|Oxalobacteraceae 28216|Betaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_95770_1 667014.Thein_1918 7.51e-94 293.0 COG0028@1|root,COG0028@2|Bacteria,2GHEM@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1448590_1 472759.Nhal_0342 1.28e-16 80.9 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RM9H@1236|Gammaproteobacteria,1WWID@135613|Chromatiales 135613|Chromatiales Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_1448590_2 515635.Dtur_1688 2.12e-23 100.0 COG0834@1|root,COG2203@1|root,COG2206@1|root,COG0834@2|Bacteria,COG2203@2|Bacteria,COG2206@2|Bacteria 2|Bacteria T PFAM metal-dependent phosphohydrolase, HD sub domain - - 2.7.13.3 ko:K02030,ko:K13040 ko02020,map02020 M00236,M00514 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022 3.A.1.3 - - EAL,GAF_2,GGDEF,HATPase_c,HD,HD_5,HisKA,PAS_3,PAS_9,Response_reg,SBP_bac_3 k59_297120_1 1042377.AFPJ01000029_gene538 4.82e-26 111.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,466FE@72275|Alteromonadaceae 1236|Gammaproteobacteria NU Neisseria PilC beta-propeller domain pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_607025_1 296591.Bpro_4504 2.71e-18 87.8 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VMXZ@28216|Betaproteobacteria,4AH7A@80864|Comamonadaceae 28216|Betaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_607025_2 1123319.AUBE01000033_gene2672 1.51e-34 132.0 COG1545@1|root,COG2030@1|root,COG1545@2|Bacteria,COG2030@2|Bacteria,2GM2A@201174|Actinobacteria 201174|Actinobacteria I nucleic-acid-binding protein containing a Zn-ribbon - - - - - - - - - - - - DUF35_N,MaoC_dehydrat_N,MaoC_dehydratas,OB_aCoA_assoc k59_972840_1 519989.ECTPHS_04239 1.96e-79 257.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1132817_1 483219.LILAB_13395 1.44e-55 184.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2WQ59@28221|Deltaproteobacteria,2YV5F@29|Myxococcales 28221|Deltaproteobacteria O Redoxin prx-4 - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_671343_1 671143.DAMO_2861 1.74e-21 89.0 COG0494@1|root,COG0494@2|Bacteria,2NPUY@2323|unclassified Bacteria 2|Bacteria L NUDIX domain mutY - 3.6.1.55 ko:K03574,ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD,NUDIX,NUDIX_4 k59_671343_2 330214.NIDE1914 3.23e-61 194.0 COG1194@1|root,COG1194@2|Bacteria,3J160@40117|Nitrospirae 40117|Nitrospirae L FES - - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD k59_1505935_1 1117647.M5M_13590 4.7e-74 244.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria,1J8XH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_141895_1 436308.Nmar_1196 9.87e-23 92.8 arCOG08694@1|root,arCOG08694@2157|Archaea,41SZ1@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_141895_2 436308.Nmar_1195 2.16e-37 127.0 arCOG10579@1|root,arCOG10579@2157|Archaea,41TAI@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_141895_3 436308.Nmar_1194 1.02e-24 96.7 arCOG08693@1|root,arCOG08693@2157|Archaea,41T7N@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_184993_1 1121931.AUHG01000012_gene2865 1.06e-42 159.0 COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,4NGJ4@976|Bacteroidetes,1HWRA@117743|Flavobacteriia 976|Bacteroidetes G COG0380 Trehalose-6-phosphate synthase otsB - 2.4.1.15,3.1.3.12 ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,Trehalose_PPase k59_1080763_1 1048834.TC41_1408 0.000593 47.4 COG1426@1|root,COG1426@2|Bacteria,1V1N7@1239|Firmicutes,4HKW3@91061|Bacilli 91061|Bacilli S Protein conserved in bacteria ymfM - - ko:K15539 - - - - ko00000 - - - DUF4115,HTH_25 k59_868935_1 247490.KSU1_D0312 2.96e-53 188.0 COG3387@1|root,COG3387@2|Bacteria,2J4DB@203682|Planctomycetes 203682|Planctomycetes G PFAM Glycoside hydrolase 15-related - - - - - - - - - - - - - k59_141911_1 436308.Nmar_1393 2.99e-77 235.0 COG0164@1|root,arCOG04121@2157|Archaea,41SK9@651137|Thaumarchaeota 651137|Thaumarchaeota L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_297144_1 330214.NIDE0912 8.76e-51 161.0 COG2963@1|root,COG2963@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07483,ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve_3 k59_297144_2 477184.KYC_14907 1.01e-86 266.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2VII1@28216|Betaproteobacteria 28216|Betaproteobacteria L similarity to GP 17427840 - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve_3 k59_1448614_1 977880.RALTA_A1487 2.36e-84 261.0 COG3395@1|root,COG3395@2|Bacteria,1MW4G@1224|Proteobacteria,2VI5S@28216|Betaproteobacteria,1K3VK@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM type III effector Hrp-dependent outers hop - 2.7.1.217 ko:K21948 - - R11706,R11707 - ko00000,ko01000 - - - DUF1357_C,DUF1537 k59_1448614_2 977880.RALTA_B1912 6.71e-32 129.0 COG0607@1|root,COG2897@1|root,COG5553@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria,COG5553@2|Bacteria,1MU3V@1224|Proteobacteria,2VH3U@28216|Betaproteobacteria,1K1TG@119060|Burkholderiaceae 28216|Betaproteobacteria P PFAM Rhodanese domain protein - - - - - - - - - - - - Rhodanese k59_828540_1 401053.AciPR4_4029 9.55e-23 94.7 COG2107@1|root,COG2107@2|Bacteria,3Y31U@57723|Acidobacteria,2JIDE@204432|Acidobacteriia 2|Bacteria S Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnD - - ko:K07083,ko:K11785 ko00130,ko01110,map00130,map01110 - R08589 RC02330 ko00000,ko00001,ko01000 - - - VitK2_biosynth k59_828540_2 1229831.M832_06230 1.32e-55 186.0 COG1060@1|root,COG1060@2|Bacteria 2|Bacteria H 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity mqnC GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 1.21.98.1,2.5.1.120,2.5.1.77 ko:K11779,ko:K11780,ko:K11781,ko:K11784,ko:K18285 ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120 M00378 R08588,R09396,R10667 RC00021,RC01381,RC02329,RC03002,RC03007,RC03234 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_1659270_1 717606.PaecuDRAFT_4795 9.16e-12 71.6 COG0745@1|root,COG0745@2|Bacteria,1TSWT@1239|Firmicutes,4HBSC@91061|Bacilli,26S4H@186822|Paenibacillaceae 91061|Bacilli T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain mprA3 - - - - - - - - - - - Response_reg,Trans_reg_C k59_1334604_1 1131266.ARWQ01000012_gene1608 6.16e-23 97.1 COG0579@1|root,arCOG00754@2157|Archaea,41SXA@651137|Thaumarchaeota 651137|Thaumarchaeota S FAD dependent oxidoreductase - - - ko:K15736 - - - - ko00000,ko01000 - - - DAO k59_1334604_2 1229909.NSED_02125 3.81e-66 207.0 COG0517@1|root,arCOG00601@2157|Archaea 2157|Archaea C CBS domain - - - - - - - - - - - - - k59_924224_1 994479.GL877881_gene6612 3.43e-26 110.0 COG0477@1|root,COG0477@2|Bacteria,2GIYR@201174|Actinobacteria,4EA9I@85010|Pseudonocardiales 201174|Actinobacteria EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1,Sugar_tr k59_512586_1 472759.Nhal_2751 7.3e-199 569.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales 135613|Chromatiales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_1334611_1 1502852.FG94_04373 3.56e-15 73.2 COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,2VS13@28216|Betaproteobacteria,473BT@75682|Oxalobacteraceae 28216|Betaproteobacteria S haloacid dehalogenase-like hydrolase gph - 3.1.3.105 ko:K22292 ko00520,map00520 - R11785 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_1178427_1 998674.ATTE01000001_gene239 1.38e-25 105.0 COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,460KI@72273|Thiotrichales 72273|Thiotrichales P Biological Process cation transport (GO 0006812), Molecular Function solute hydrogen antiporter activity (GO 0015299), Cellular Component integral to membrane (GO 0016021), Biological Process transmembrane transport (GO 0055085) - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger k59_1178427_2 765912.Thimo_1197 4.51e-76 243.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1WVWX@135613|Chromatiales 135613|Chromatiales CH TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 - - - ko:K18800 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04987,R08768 RC00046 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_924240_2 251221.35213298 2.16e-16 75.9 COG0758@1|root,COG0758@2|Bacteria,1GACU@1117|Cyanobacteria 1117|Cyanobacteria LU Putative molybdenum carrier - - - - - - - - - - - - MoCo_carrier k59_1506004_1 267747.PPA0686 1.2e-07 56.2 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily nanT GO:0003674,GO:0005215,GO:0005342,GO:0005351,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0008643,GO:0015075,GO:0015077,GO:0015078,GO:0015136,GO:0015144,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015711,GO:0015739,GO:0015849,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034219,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1901264,GO:1901505,GO:1902600,GO:1903825,GO:1905039 - ko:K03290,ko:K08178 - - - - ko00000,ko02000 2.A.1.12 - iECUMN_1333.ECUMN_3698 MFS_1,Sugar_tr k59_1080812_2 572477.Alvin_2082 2.12e-42 149.0 COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,1T20F@1236|Gammaproteobacteria,1WW2D@135613|Chromatiales 135613|Chromatiales E PFAM Prephenate dehydrogenase - - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_512607_2 1229909.NSED_05065 1.3e-62 193.0 arCOG07348@1|root,arCOG07348@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1506007_1 518766.Rmar_1857 1.67e-26 110.0 COG0471@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0569@2|Bacteria,4NF52@976|Bacteroidetes,1FIP9@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P Sodium:sulfate symporter transmembrane region - - - - - - - - - - - - CitMHS,TrkA_C k59_242280_1 1169161.KB897740_gene2207 1.42e-16 77.0 COG0517@1|root,COG0517@2|Bacteria,2IHPB@201174|Actinobacteria 201174|Actinobacteria S Cbs domain - - - - - - - - - - - - CBS k59_242280_2 1089546.AQUI01000002_gene2514 1.47e-08 56.2 COG0517@1|root,COG0517@2|Bacteria,2IM3K@201174|Actinobacteria,4098B@622450|Actinopolysporales 201174|Actinobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_1599427_1 1380394.JADL01000002_gene1101 6.07e-117 342.0 COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,2TTF5@28211|Alphaproteobacteria,2JRHQ@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_512612_1 2002.JOEQ01000023_gene1203 1.08e-64 219.0 COG1020@1|root,COG1020@2|Bacteria,2I8ST@201174|Actinobacteria 2|Bacteria Q AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_671449_1 330214.NIDE4033 6.09e-72 218.0 COG1225@1|root,COG1225@2|Bacteria,3J12D@40117|Nitrospirae 40117|Nitrospirae O AhpC/TSA family - - - - - - - - - - - - AhpC-TSA k59_1187917_2 1254432.SCE1572_10470 1.03e-57 182.0 COG2185@1|root,COG2185@2|Bacteria,1RKGS@1224|Proteobacteria,42SKV@68525|delta/epsilon subdivisions,2WP2X@28221|Deltaproteobacteria,2YV7A@29|Myxococcales 28221|Deltaproteobacteria I B12 binding domain - - 5.4.99.2 ko:K01849 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding k59_1399625_1 1429916.X566_18990 3.21e-75 239.0 COG3239@1|root,COG3239@2|Bacteria,1MUHK@1224|Proteobacteria,2TSTR@28211|Alphaproteobacteria,3JTTJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Fatty acid desaturase MA20_28095 - - - - - - - - - - - FA_desaturase k59_1607150_2 272134.KB731324_gene3084 6.65e-45 160.0 COG0187@1|root,COG0187@2|Bacteria,1G139@1117|Cyanobacteria,1H885@1150|Oscillatoriales 1117|Cyanobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Intein_splicing,Toprim k59_724581_2 330214.NIDE4127 1.22e-29 117.0 COG1185@1|root,COG1185@2|Bacteria,3J0DX@40117|Nitrospirae 40117|Nitrospirae J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_773659_1 1125863.JAFN01000001_gene770 3.66e-56 192.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,42P8V@68525|delta/epsilon subdivisions,2WKIF@28221|Deltaproteobacteria 28221|Deltaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.44 ko:K00666,ko:K20034 ko00920,map00920 - R10820 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_151945_2 1192034.CAP_1727 8.93e-38 137.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42R8B@68525|delta/epsilon subdivisions,2X5KI@28221|Deltaproteobacteria,2YUUJ@29|Myxococcales 28221|Deltaproteobacteria L Endonuclease/Exonuclease/phosphatase family xth - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_724602_1 751994.AGIG01000017_gene55 3.88e-60 192.0 COG0457@1|root,COG0457@2|Bacteria,1QZ3D@1224|Proteobacteria 1224|Proteobacteria S Putative 2OG-Fe(II) oxygenase - - - - - - - - - - - - 2OG-FeII_Oxy_5 k59_1091654_1 469383.Cwoe_0601 1.04e-49 180.0 COG2114@1|root,COG2909@1|root,COG3899@1|root,COG2114@2|Bacteria,COG2909@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria 201174|Actinobacteria T Adenylyl cyclase class-3 4 guanylyl cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - AAA_16,Guanylate_cyc k59_1187963_1 1357714.A0A067XRH5_9CAUD 2.37e-06 53.9 4QAWI@10239|Viruses,4QW40@35237|dsDNA viruses no RNA stage,4QPUX@28883|Caudovirales,4QINW@10662|Myoviridae 10662|Myoviridae S Pfam:Peptidase_S77 - - - - - - - - - - - - - k59_1187964_1 1229909.NSED_05375 1.66e-93 278.0 arCOG02703@1|root,arCOG02703@2157|Archaea 2157|Archaea S Methyltransferase type 11 - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 k59_195967_1 1131269.AQVV01000003_gene769 1.39e-12 70.9 COG0457@1|root,COG3794@1|root,COG0457@2|Bacteria,COG3794@2|Bacteria 2|Bacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - CarboxypepD_reg,TPR_16,fn3_3 k59_1399670_1 1121878.AUGL01000021_gene2815 6.21e-152 444.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_308003_1 671143.DAMO_0339 8.67e-81 249.0 COG0057@1|root,COG0057@2|Bacteria,2NNPP@2323|unclassified Bacteria 2|Bacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_618052_1 330214.NIDE4238 2.26e-121 369.0 COG0495@1|root,COG0495@2|Bacteria,3J0F8@40117|Nitrospirae 40117|Nitrospirae J Leucyl-tRNA synthetase, Domain 2 leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1 k59_308015_1 1123371.ATXH01000001_gene1282 4.96e-09 60.8 COG0664@1|root,COG0664@2|Bacteria,2GHZ5@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria K helix_turn_helix, cAMP Regulatory protein - - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_935168_2 1120977.JHUX01000003_gene910 3.72e-18 85.1 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,3NJN7@468|Moraxellaceae 1236|Gammaproteobacteria F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_1035512_1 211114.JOEF01000054_gene4695 4.32e-12 72.8 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,2GKU1@201174|Actinobacteria,4DYQE@85010|Pseudonocardiales 201174|Actinobacteria H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE - - - - - - - - - - - CTP_transf_like,PfkB k59_1458240_1 1042377.AFPJ01000048_gene2682 4.21e-39 140.0 COG1846@1|root,COG1846@2|Bacteria,1RF8X@1224|Proteobacteria,1S4RW@1236|Gammaproteobacteria,466UV@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG1846 Transcriptional regulators - - - - - - - - - - - - MarR k59_359938_1 1131269.AQVV01000031_gene286 7.43e-48 175.0 COG4258@1|root,COG4258@2|Bacteria 2|Bacteria I 3-demethylubiquinone-9 3-O-methyltransferase activity hpnN - - ko:K07003 - - - - ko00000 - - - MMPL k59_935192_1 436308.Nmar_0868 5.95e-59 195.0 COG0064@1|root,arCOG01718@2157|Archaea,41S9S@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_935192_2 1229909.NSED_04845 4.01e-17 74.7 arCOG10556@1|root,arCOG10556@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_20730_1 1535287.JP74_04925 6.19e-81 266.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,3N67P@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria C E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1458263_1 56780.SYN_01127 2.27e-47 173.0 COG1345@1|root,COG1957@1|root,COG3204@1|root,COG1345@2|Bacteria,COG1957@2|Bacteria,COG3204@2|Bacteria,1QVAA@1224|Proteobacteria,43BPG@68525|delta/epsilon subdivisions,2X70T@28221|Deltaproteobacteria,2MR3K@213462|Syntrophobacterales 28221|Deltaproteobacteria N nucleoside hydrolase - - - - - - - - - - - - - k59_1399729_1 1415166.NONO_c36150 4.64e-80 253.0 COG2159@1|root,COG2159@2|Bacteria,2HJ6D@201174|Actinobacteria,4G5GZ@85025|Nocardiaceae 201174|Actinobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_152050_1 272624.lpg0187 8.77e-52 179.0 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,1RZXV@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_724666_1 754476.Q7A_567 1.61e-33 118.0 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S8RQ@1236|Gammaproteobacteria,460WA@72273|Thiotrichales 72273|Thiotrichales D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB k59_724666_2 626418.bglu_1g08150 1.24e-29 115.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2VHN9@28216|Betaproteobacteria,1K1SM@119060|Burkholderiaceae 28216|Betaproteobacteria L AAA ATPase central domain protein rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_1344284_1 472759.Nhal_0820 4.15e-142 410.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1WX09@135613|Chromatiales 135613|Chromatiales P cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_1344284_2 926556.Echvi_4467 3.06e-39 135.0 COG3439@1|root,COG3439@2|Bacteria,4NQRI@976|Bacteroidetes,47UNM@768503|Cytophagia 976|Bacteroidetes S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_465593_1 1121374.KB891575_gene1549 6.14e-116 346.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria P phosphate transporter pitA GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_1035564_1 420662.Mpe_A2653 5.46e-19 82.4 28V8Y@1|root,2ZHBX@2|Bacteria,1RD5G@1224|Proteobacteria,2VS15@28216|Betaproteobacteria,1KKWW@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Methylamine dehydrogenase, L chain aauA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.4.9.1,1.4.9.2 ko:K13371,ko:K15228 ko00350,ko00360,ko00680,ko00950,ko01100,ko01110,ko01120,map00350,map00360,map00680,map00950,map01100,map01110,map01120 - R00606,R02382,R02612,R04300 RC00062,RC00189 ko00000,ko00001,ko01000 - - - Me-amine-dh_L k59_1035564_2 247639.MGP2080_12534 3.83e-23 94.0 COG2010@1|root,COG2010@2|Bacteria,1N8E4@1224|Proteobacteria,1T0F4@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - - k59_1144600_1 243365.CV_4198 1.56e-43 146.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,2VKUA@28216|Betaproteobacteria,2KPFZ@206351|Neisseriales 206351|Neisseriales K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_1144600_2 2340.JV46_16160 6.23e-79 236.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,1S22R@1236|Gammaproteobacteria,1J5SI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_935239_1 1283300.ATXB01000001_gene1164 2.67e-76 237.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RX39@1236|Gammaproteobacteria,1XE6N@135618|Methylococcales 135618|Methylococcales C Part of a membrane complex involved in electron transport - - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_618146_1 316067.Geob_1083 1.66e-112 332.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,42PGW@68525|delta/epsilon subdivisions,2WMMZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Alcohol dehydrogenase zinc-binding domain protein - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_565525_1 323261.Noc_2331 4.52e-92 301.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_308094_1 1122599.AUGR01000010_gene1027 1.33e-51 173.0 COG3971@1|root,COG3971@2|Bacteria,1RGHI@1224|Proteobacteria 1224|Proteobacteria Q 2-keto-4-pentenoate hydratase - - 4.1.1.77 ko:K01617 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 M00569 R02602,R05374 RC00751,RC02672 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_411149_1 686340.Metal_2750 5.49e-36 143.0 COG0765@1|root,COG0834@1|root,COG0765@2|Bacteria,COG0834@2|Bacteria,1QN80@1224|Proteobacteria,1RR3B@1236|Gammaproteobacteria 1236|Gammaproteobacteria P amino acid ABC transporter yecS GO:0000099,GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006791,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015184,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015811,GO:0015849,GO:0016020,GO:0022857,GO:0033229,GO:0034220,GO:0042883,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0072349,GO:0098655,GO:0098656,GO:1901682,GO:1902475,GO:1903712,GO:1903825,GO:1905039 - ko:K02029,ko:K10009,ko:K16962 ko02010,map02010 M00234,M00236,M00586 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.10,3.A.1.3.14 - iJN746.PP_0226 BPD_transp_1 k59_1550727_1 1121937.AUHJ01000015_gene138 1.5e-55 188.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,465K9@72275|Alteromonadaceae 1236|Gammaproteobacteria F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - - - - - - - - - - - Amidohydro_1 k59_152120_1 1121481.AUAS01000020_gene5199 1.95e-16 84.0 COG2374@1|root,COG4886@1|root,COG2374@2|Bacteria,COG4886@2|Bacteria,4NI5S@976|Bacteroidetes,47NAE@768503|Cytophagia 976|Bacteroidetes G Endonuclease/Exonuclease/phosphatase family - - - ko:K07004 - - - - ko00000 - - - Big_5,Calx-beta,Exo_endo_phos,He_PIG,LTD,VCBS k59_1251272_1 338963.Pcar_0101 4.65e-74 239.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria,43SBU@69541|Desulfuromonadales 28221|Deltaproteobacteria J tRNA synthetases class I (E and Q), anti-codon binding domain glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C k59_565538_1 331869.BAL199_04629 1.42e-29 118.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TS7G@28211|Alphaproteobacteria,4BPPN@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S ABC transporter chvD - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_Xtn k59_879181_1 330214.NIDE0767 3.15e-102 308.0 COG0206@1|root,COG0206@2|Bacteria,3J0D4@40117|Nitrospirae 40117|Nitrospirae D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_1251289_1 525903.Taci_1609 5.35e-18 84.7 COG0119@1|root,COG0119@2|Bacteria,3T9U1@508458|Synergistetes 508458|Synergistetes H Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1251296_1 1894.JOER01000049_gene5075 2.8e-10 67.4 COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria 201174|Actinobacteria Q Non-ribosomal peptide synthetase modules and related proteins - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,Methyltransf_11,Methyltransf_12,PP-binding,Thioesterase k59_1251296_2 926550.CLDAP_16780 1.5e-07 52.8 COG5598@1|root,COG5598@2|Bacteria 2|Bacteria H trimethylamine methyltransferase - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB k59_465655_1 880073.Calab_3405 3.15e-10 66.2 COG4191@1|root,COG4191@2|Bacteria,2NPGF@2323|unclassified Bacteria 2|Bacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_308139_1 857087.Metme_3943 1.43e-132 392.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1XDXR@135618|Methylococcales 135618|Methylococcales J PFAM Aminoacyl-tRNA synthetase, class II (G H P S), conserved region hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_308139_2 876044.IMCC3088_2458 0.000329 42.0 COG2976@1|root,COG2976@2|Bacteria 2|Bacteria CO Protein conserved in bacteria yfgM GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0044425,GO:0044459,GO:0044464,GO:0071575,GO:0071944,GO:0098552 - - - - - - - - - - TPR_21 k59_309781_1 797304.Natgr_1480 1.9e-52 182.0 COG4427@1|root,arCOG09080@2157|Archaea,2XWG2@28890|Euryarchaeota,23TPM@183963|Halobacteria 183963|Halobacteria S Uncharacterized protein conserved in bacteria (DUF2332) - - - - - - - - - - - - DUF2332 k59_1401402_1 1229909.NSED_01430 1.24e-66 218.0 COG0260@1|root,arCOG04322@2157|Archaea,41SYD@651137|Thaumarchaeota 651137|Thaumarchaeota E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_412880_2 754476.Q7A_2409 2.33e-09 59.7 COG4726@1|root,COG4726@2|Bacteria,1N7KP@1224|Proteobacteria,1SCM5@1236|Gammaproteobacteria,4636X@72273|Thiotrichales 72273|Thiotrichales NU Type IV pilus assembly protein PilX C-term - - - ko:K02673 - - - - ko00000,ko02035,ko02044 - - - PilX,PilX_N k59_1093385_1 330214.NIDE0262 8.76e-63 206.0 COG0544@1|root,COG0544@2|Bacteria,3J12E@40117|Nitrospirae 40117|Nitrospirae O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - Trigger_C,Trigger_N k59_197931_1 502025.Hoch_6864 4.3e-125 377.0 COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,42NAD@68525|delta/epsilon subdivisions,2WKEY@28221|Deltaproteobacteria,2Z1IJ@29|Myxococcales 28221|Deltaproteobacteria E PFAM peptidase M3A and M3B thimet oligopeptidase F pepF - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_21474_1 309803.CTN_0206 4.56e-20 92.8 COG2208@1|root,COG2208@2|Bacteria,2GCU2@200918|Thermotogae 200918|Thermotogae KT Stage II sporulation - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - SpoIIE k59_1460004_1 1046724.KB889900_gene3205 4.95e-28 113.0 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,46AKM@72275|Alteromonadaceae 1236|Gammaproteobacteria H ThiF family moeB - 2.7.7.80,2.8.1.11 ko:K21029,ko:K21147 ko04122,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - Prok-JAB,Rhodanese,ThiF,ThiS k59_1460004_2 224324.aq_2197 2.1e-49 162.0 COG3063@1|root,COG3063@2|Bacteria 2|Bacteria NU photosynthesis sscB - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_361626_2 589865.DaAHT2_1381 6.61e-24 101.0 COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,42NI3@68525|delta/epsilon subdivisions,2WJ6P@28221|Deltaproteobacteria,2MHUH@213118|Desulfobacterales 28221|Deltaproteobacteria E Periplasmic binding protein - - - - - - - - - - - - Peripla_BP_6 k59_467362_1 1232410.KI421412_gene330 4.64e-85 268.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,43T3R@69541|Desulfuromonadales 28221|Deltaproteobacteria M PFAM peptidase S1 and S6, chymotrypsin Hap degQ - 3.4.21.107 ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1146638_1 1229909.NSED_09725 1.89e-46 150.0 arCOG08691@1|root,arCOG08691@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1146638_2 1229909.NSED_02945 1.01e-45 151.0 COG0071@1|root,arCOG01832@2157|Archaea 2157|Archaea O Belongs to the small heat shock protein (HSP20) family hsp20 - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_1146638_3 1229909.NSED_02950 1.69e-20 87.8 COG1938@1|root,arCOG00347@2157|Archaea 2157|Archaea S COG1938 Archaeal enzymes of ATP-grasp superfamily - - - ko:K06869 - - - - ko00000 - - - PAC2 k59_983644_2 298654.FraEuI1c_4777 1.54e-39 139.0 COG1024@1|root,COG1024@2|Bacteria,2GKJ6@201174|Actinobacteria 201174|Actinobacteria I Belongs to the enoyl-CoA hydratase isomerase family echA19 - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_681283_1 1123392.AQWL01000007_gene988 9.46e-44 149.0 COG3369@1|root,COG3369@2|Bacteria,1RCN9@1224|Proteobacteria 1224|Proteobacteria S PFAM Iron-binding zinc finger CDGSH type - - - - - - - - - - - - Fer4_19,Ferritin-like,zf-CDGSH k59_993935_1 1229780.BN381_290075 8.64e-52 172.0 COG0208@1|root,COG0208@2|Bacteria 2|Bacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - - - - - - - - - - - Ald_deCOase k59_1516043_1 883.DvMF_1631 1.95e-54 179.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,42RZQ@68525|delta/epsilon subdivisions,2WNKI@28221|Deltaproteobacteria,2MG4G@213115|Desulfovibrionales 28221|Deltaproteobacteria K response regulator, receiver - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_1255767_1 1410620.SHLA_10c000070 6.26e-15 73.6 COG2010@1|root,COG2010@2|Bacteria,1MZSK@1224|Proteobacteria,2UC5Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG2010 Cytochrome c, mono- and diheme variants - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_1255767_2 626887.J057_00095 9.58e-48 158.0 COG4454@1|root,COG4454@2|Bacteria,1R91G@1224|Proteobacteria,1T0G8@1236|Gammaproteobacteria,46CCA@72275|Alteromonadaceae 1236|Gammaproteobacteria P Copper-binding protein - - - - - - - - - - - - Copper-bind,Cupredoxin_1 k59_1342_1 406124.ACPC01000022_gene4197 1.41e-44 160.0 COG1012@1|root,COG1012@2|Bacteria,1UHQT@1239|Firmicutes,4IS6J@91061|Bacilli,1ZSC0@1386|Bacillus 91061|Bacilli C Aldehyde dehydrogenase family acdH - 1.1.1.1,1.2.1.10,1.2.1.87 ko:K04072,ko:K13922 ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00640,map00650,map01100,map01110,map01120,map01130,map01220 - R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927,R09097 RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195 ko00000,ko00001,ko01000 - - - Aldedh k59_471570_1 396588.Tgr7_0745 2.85e-123 362.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1WX79@135613|Chromatiales 135613|Chromatiales E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_1516044_1 1192034.CAP_4329 1.64e-34 121.0 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,42TPZ@68525|delta/epsilon subdivisions,2WQ0P@28221|Deltaproteobacteria,2YVRR@29|Myxococcales 28221|Deltaproteobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_1516044_2 903818.KI912268_gene2408 1.24e-43 159.0 COG1185@1|root,COG1185@2|Bacteria,3Y2UG@57723|Acidobacteria 57723|Acidobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_1150794_1 443152.MDG893_08751 0.000248 42.7 COG2220@1|root,COG2220@2|Bacteria,1R5GU@1224|Proteobacteria,1SIPM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Zn-dependent hydrolases of the beta-lactamase fold - - - - - - - - - - - - Lactamase_B_3 k59_1150794_2 1163409.UUA_11613 1.8e-68 217.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW8A@1224|Proteobacteria,1RRNV@1236|Gammaproteobacteria,1X6MJ@135614|Xanthomonadales 135614|Xanthomonadales L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_29,HTH_33 k59_941803_2 2002.JOEQ01000001_gene4884 1.46e-207 582.0 COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4EH5G@85012|Streptosporangiales 201174|Actinobacteria I Thiolase, C-terminal domain fadA6 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_576252_1 1041146.ATZB01000044_gene1060 2.09e-14 70.1 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2TUF2@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_576252_2 656519.Halsa_1560 1.73e-32 127.0 COG1757@1|root,COG1757@2|Bacteria,1TP8A@1239|Firmicutes,247V4@186801|Clostridia,3WA9C@53433|Halanaerobiales 186801|Clostridia C PFAM Na H antiporter - - - - - - - - - - - - Na_H_antiporter k59_941810_1 1219084.AP014508_gene1090 2.04e-41 150.0 COG0205@1|root,COG0205@2|Bacteria,2GC8H@200918|Thermotogae 200918|Thermotogae F Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_471583_1 886293.Sinac_2520 2.12e-64 220.0 COG2217@1|root,COG2217@2|Bacteria,2IXAD@203682|Planctomycetes 203682|Planctomycetes P heavy metal translocating P-type ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_210787_1 381666.H16_B2008 1.25e-30 118.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VKB2@28216|Betaproteobacteria,1KCHI@119060|Burkholderiaceae 28216|Betaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_524209_1 1229780.BN381_290040 9.19e-68 221.0 COG3669@1|root,COG3669@2|Bacteria,2HUEI@201174|Actinobacteria 201174|Actinobacteria G Alpha-L-fucosidase - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos k59_785762_1 204773.HEAR3270 1.28e-67 215.0 COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,2VK50@28216|Betaproteobacteria,473G8@75682|Oxalobacteraceae 28216|Betaproteobacteria C Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.41 ko:K00030 ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00709 RC00114 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_54516_1 246197.MXAN_1103 3.23e-61 203.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,2YTTF@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran k59_629143_1 1045856.EcWSU1_03506 1.31e-48 176.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,3X10P@547|Enterobacter 1236|Gammaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD k59_1516053_1 926561.KB900622_gene462 8.3e-63 209.0 COG4974@1|root,COG4974@2|Bacteria,1TR57@1239|Firmicutes,24ACW@186801|Clostridia,3WB6M@53433|Halanaerobiales 186801|Clostridia L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_1516053_2 1121396.KB892913_gene116 5.7e-98 305.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,42WI2@68525|delta/epsilon subdivisions,2WRPD@28221|Deltaproteobacteria,2MQ18@213118|Desulfobacterales 28221|Deltaproteobacteria S Transposase zinc-binding domain - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_889996_1 323261.Noc_1667 5.45e-153 437.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1WWWT@135613|Chromatiales 135613|Chromatiales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_889996_2 1049564.TevJSym_bc00140 1.27e-42 148.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria,1J5AJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG0331 (acyl-carrier-protein) S-malonyltransferase fabD GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - iEcE24377_1341.EcE24377A_1213,iJN746.PP_1913,iPC815.YPO1598 Acyl_transf_1 k59_1046587_1 237368.SCABRO_02753 1.58e-42 150.0 COG0624@1|root,COG0624@2|Bacteria,2J1RT@203682|Planctomycetes 203682|Planctomycetes E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_785779_1 1121935.AQXX01000136_gene4026 7.15e-18 86.7 COG0457@1|root,COG0457@2|Bacteria,1R50I@1224|Proteobacteria,1RSP6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_576281_1 485918.Cpin_3938 4.72e-29 112.0 COG0388@1|root,COG0388@2|Bacteria,4NEME@976|Bacteroidetes,1IPIY@117747|Sphingobacteriia 976|Bacteroidetes S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase pabB - 3.5.1.53,3.5.1.6 ko:K01431,ko:K12251 ko00240,ko00330,ko00410,ko00770,ko00983,ko01100,map00240,map00330,map00410,map00770,map00983,map01100 M00046 R00905,R01152,R04666,R08228 RC00096 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase k59_1412684_2 349124.Hhal_1358 2.62e-49 171.0 COG2199@1|root,COG3706@2|Bacteria,1N6SR@1224|Proteobacteria,1T2CM@1236|Gammaproteobacteria 1236|Gammaproteobacteria T TIGRFAM Diguanylate cyclase - - - - - - - - - - - - GGDEF k59_106763_1 1205680.CAKO01000038_gene2061 5.58e-36 137.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2TVXT@28211|Alphaproteobacteria,2JQX8@204441|Rhodospirillales 204441|Rhodospirillales U Major Facilitator Superfamily - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_682334_1 948106.AWZT01000020_gene4095 4.42e-115 355.0 COG0323@1|root,COG0323@2|Bacteria,1R57G@1224|Proteobacteria,2VP7W@28216|Betaproteobacteria,1K86N@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA mismatch repair - - - - - - - - - - - - HATPase_c_3 k59_55492_1 1110502.TMO_2573 9.04e-78 257.0 COG0119@1|root,COG4770@1|root,COG0119@2|Bacteria,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2JPR7@204441|Rhodospirillales 204441|Rhodospirillales I COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit - - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_630114_1 1472716.KBK24_0133265 4.09e-27 111.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2VHJ8@28216|Betaproteobacteria,1K251@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_630114_2 748280.NH8B_0919 4.84e-58 185.0 COG1376@1|root,COG1376@2|Bacteria,1RHBG@1224|Proteobacteria,2VQT7@28216|Betaproteobacteria,2KRCE@206351|Neisseriales 206351|Neisseriales S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD k59_630114_3 292415.Tbd_0727 2.61e-47 163.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2VHAR@28216|Betaproteobacteria,1KRAB@119069|Hydrogenophilales 119069|Hydrogenophilales G Glycosyl hydrolase family 3 N terminal domain - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_1360886_1 251229.Chro_4403 3.64e-53 188.0 COG0068@1|root,COG0068@2|Bacteria,1G063@1117|Cyanobacteria,3VI6E@52604|Pleurocapsales 1117|Cyanobacteria O PFAM HypF finger hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_1099738_2 572478.Vdis_0258 4.26e-06 49.3 COG1250@1|root,arCOG00249@2157|Archaea,2XPQ7@28889|Crenarchaeota 28889|Crenarchaeota I 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35,4.2.1.17 ko:K15016 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00374,M00375 R01975,R03026 RC00117,RC00831 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_838465_1 426117.M446_1338 9.34e-49 165.0 COG1024@1|root,COG1024@2|Bacteria,1RDWE@1224|Proteobacteria,2UA9Q@28211|Alphaproteobacteria,1JXC9@119045|Methylobacteriaceae 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - - - - - - - - - - - ECH_1 k59_420567_2 1268068.PG5_06550 6.41e-93 285.0 COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,1RM7W@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Required for the activity of the bacterial periplasmic transport system of putrescine potF - - ko:K11073 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - SBP_bac_8 k59_106780_1 322710.Avin_42260 2.31e-13 70.5 COG1309@1|root,COG1309@2|Bacteria,1R59A@1224|Proteobacteria,1S20U@1236|Gammaproteobacteria 1236|Gammaproteobacteria K tetR family - - - - - - - - - - - - TetR_N k59_1256827_2 883.DvMF_2997 8.88e-32 130.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,42MPH@68525|delta/epsilon subdivisions,2WJHW@28221|Deltaproteobacteria,2M7QR@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM cell wall hydrolase autolysin amiC - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,TPR_6 k59_211602_1 1205908.AKXW01000177_gene3035 3.03e-59 200.0 COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,1S06C@1236|Gammaproteobacteria,1XUEX@135623|Vibrionales 135623|Vibrionales S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_1412709_1 1232410.KI421420_gene3224 1.68e-12 72.8 COG2204@1|root,COG2208@1|root,COG2204@2|Bacteria,COG2208@2|Bacteria,1N3FS@1224|Proteobacteria,42Y6X@68525|delta/epsilon subdivisions,2WU8A@28221|Deltaproteobacteria,43T8K@69541|Desulfuromonadales 28221|Deltaproteobacteria T Sigma factor PP2C-like phosphatases - - - - - - - - - - - - Response_reg,SpoIIE k59_1204695_1 398767.Glov_3356 1.46e-08 62.0 COG0438@1|root,COG0438@2|Bacteria,1MWYH@1224|Proteobacteria,42Q22@68525|delta/epsilon subdivisions,2WK61@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1,TPR_16,TPR_8 k59_1308240_1 743299.Acife_2627 3.26e-35 129.0 COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,1RNC5@1236|Gammaproteobacteria,2NDHI@225057|Acidithiobacillales 225057|Acidithiobacillales C Reduction of activated sulfate into sulfite - - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_1569451_2 1042163.BRLA_c005890 1.38e-18 91.3 COG0500@1|root,COG2226@2|Bacteria,1TQEA@1239|Firmicutes,4HJYK@91061|Bacilli,26TVZ@186822|Paenibacillaceae 91061|Bacilli Q O-methyltransferase menG - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_25,Ubie_methyltran k59_1569451_3 682795.AciX8_4786 2.58e-07 54.7 COG4319@1|root,COG4319@2|Bacteria,3Y5FP@57723|Acidobacteria,2JN7M@204432|Acidobacteriia 204432|Acidobacteriia S SnoaL-like domain - - - - - - - - - - - - DUF4440 k59_1569451_4 1227457.C451_07492 1.57e-19 90.9 arCOG02703@1|root,arCOG02703@2157|Archaea,2XV0I@28890|Euryarchaeota,23SUR@183963|Halobacteria 183963|Halobacteria Q Methyltransferase type 11 aknG - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_942624_2 264198.Reut_A0368 1.2e-05 47.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2VITN@28216|Betaproteobacteria,1K03E@119060|Burkholderiaceae 28216|Betaproteobacteria EGP Major facilitator superfamily yajR - - - - - - - - - - - MFS_1,Sugar_tr k59_472371_1 546414.Deide_16490 9.69e-05 47.4 COG1600@1|root,COG1600@2|Bacteria,1WJ6B@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C TIGRFAM iron-sulfur cluster binding protein - - - - - - - - - - - - DUF1730,Fer4_16,HEAT,HEAT_2 k59_472371_2 935840.JAEQ01000002_gene3240 1.51e-31 121.0 COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,2TSRN@28211|Alphaproteobacteria,43J7S@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G Glycosyl hydrolase family 1 bglA - 3.2.1.21 ko:K05350 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - - - Glyco_hydro_1 k59_1204701_1 290398.Csal_3233 1.47e-39 140.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1XJ5P@135619|Oceanospirillales 135619|Oceanospirillales F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_1622019_1 1242864.D187_008933 4.79e-63 216.0 COG3391@1|root,COG3391@2|Bacteria,1R7E0@1224|Proteobacteria,42Z2U@68525|delta/epsilon subdivisions,2WTYD@28221|Deltaproteobacteria,2YX64@29|Myxococcales 28221|Deltaproteobacteria S Cytochrome D1 heme domain - - - - - - - - - - - - Cytochrom_D1 k59_368459_1 472759.Nhal_3802 4.79e-64 218.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1WXCY@135613|Chromatiales 135613|Chromatiales G phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1047424_1 883126.HMPREF9710_02673 2.76e-20 95.5 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WI6V@28216|Betaproteobacteria,478E4@75682|Oxalobacteraceae 28216|Betaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS,dCache_1 k59_890844_1 565045.NOR51B_1193 1.11e-91 285.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1J5IY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG0577 ABC-type antimicrobial peptide transport system, permease component VP1997 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_890844_2 446469.Sked_32350 4.64e-08 57.4 COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria 201174|Actinobacteria V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1622021_1 1049564.TevJSym_br00100 1.51e-34 132.0 COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,1S3RM@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - - - - - - - - - - - - k59_890850_1 472759.Nhal_2872 3.91e-129 402.0 COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1SYTD@1236|Gammaproteobacteria,1X2IM@135613|Chromatiales 135613|Chromatiales EO Peptidase family M28 - - - - - - - - - - - - PDZ_2,Peptidase_M1,Peptidase_M28 k59_1204717_1 1249627.D779_4060 2.09e-72 236.0 COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,1SX9U@1236|Gammaproteobacteria,1X0R6@135613|Chromatiales 135613|Chromatiales U Predicted Permease Membrane Region - - - - - - - - - - - - Asp-Al_Ex,TrkA_C k59_263932_1 443152.MDG893_19784 4.58e-95 287.0 COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,1RQRU@1236|Gammaproteobacteria,467JD@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family tauD - 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_532054_2 1123504.JQKD01000004_gene5016 2.6e-16 77.4 COG1305@1|root,COG1305@2|Bacteria,1R9XR@1224|Proteobacteria,2VIBI@28216|Betaproteobacteria,4AE08@80864|Comamonadaceae 28216|Betaproteobacteria E Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core k59_1629450_1 1268635.Loa_01708 1.17e-73 228.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,1JD7Q@118969|Legionellales 118969|Legionellales J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_1629450_2 1118235.CAJH01000027_gene1885 7.07e-06 47.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1X31M@135614|Xanthomonadales 135614|Xanthomonadales I Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_1107072_1 436308.Nmar_0497 1.37e-38 139.0 COG0520@1|root,arCOG00065@2157|Archaea,41SCV@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_1107072_2 1229909.NSED_02500 3.84e-56 177.0 COG0822@1|root,arCOG02077@2157|Archaea,41SPT@651137|Thaumarchaeota 651137|Thaumarchaeota C SUF system FeS assembly protein - - - ko:K04488 - - - - ko00000 - - - NifU_N k59_898127_1 396588.Tgr7_2455 2.65e-111 334.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1WW8D@135613|Chromatiales 135613|Chromatiales C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_64890_1 1137745.H6WG25_9CAUD 4.73e-19 83.6 4QBKF@10239|Viruses,4QW0F@35237|dsDNA viruses no RNA stage,4QRGA@28883|Caudovirales,4QIZG@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_64890_2 445686.E3SLE6_9CAUD 2.1e-25 101.0 4QGNK@10239|Viruses,4R0JU@35237|dsDNA viruses no RNA stage,4QSVD@28883|Caudovirales,4QJ6U@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1368050_1 575540.Isop_3324 1.6e-39 145.0 COG0809@1|root,COG0809@2|Bacteria,2IWS2@203682|Planctomycetes 203682|Planctomycetes J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_898130_1 563192.HMPREF0179_03457 5.72e-23 103.0 COG0749@1|root,COG0749@2|Bacteria,1P27P@1224|Proteobacteria,42YUP@68525|delta/epsilon subdivisions,2WTS1@28221|Deltaproteobacteria,2MAPB@213115|Desulfovibrionales 28221|Deltaproteobacteria L DNA polymerase A domain - - - - - - - - - - - - DNA_pol_A k59_1629458_1 330214.NIDE1016 1.04e-86 273.0 COG0768@1|root,COG0768@2|Bacteria,3J0FY@40117|Nitrospirae 40117|Nitrospirae M Penicillin-binding Protein dimerisation domain - - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_164548_1 396588.Tgr7_1409 1.9e-75 248.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1WWG0@135613|Chromatiales 135613|Chromatiales L Helicase - - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,Helicase_C_2 k59_164548_2 329726.AM1_5485 1.36e-06 50.1 COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria 1117|Cyanobacteria S Belongs to the SOS response-associated peptidase family - - - - - - - - - - - - SRAP k59_1213813_1 314230.DSM3645_21809 6.74e-85 263.0 COG0334@1|root,COG0334@2|Bacteria,2IWWC@203682|Planctomycetes 203682|Planctomycetes C Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_1474216_1 1232437.KL662006_gene4388 1.03e-46 156.0 2C477@1|root,32RDF@2|Bacteria,1RKW1@1224|Proteobacteria,42SWN@68525|delta/epsilon subdivisions,2WP88@28221|Deltaproteobacteria 28221|Deltaproteobacteria S DGC domain - - - - - - - - - - - - DGC k59_690813_1 465515.Mlut_14300 5.3e-67 217.0 COG3464@1|root,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria,1WAN7@1268|Micrococcaceae 201174|Actinobacteria L PFAM Transposase - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K07485 - - - - ko00000 - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_1629460_1 1298867.AUES01000122_gene2894 4.92e-05 48.9 2E560@1|root,32ZYT@2|Bacteria,1RAE3@1224|Proteobacteria,2U7CW@28211|Alphaproteobacteria,3JYRK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1474226_1 187272.Mlg_0173 8.7e-102 307.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1WWAV@135613|Chromatiales 135613|Chromatiales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_741012_1 1196835.A458_17530 6.26e-24 98.2 COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,1RQD2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative cyclase - - - - - - - - - - - - Cyclase k59_741012_2 414684.RC1_1776 1.66e-06 50.1 COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,2VGKD@28211|Alphaproteobacteria,2JP8T@204441|Rhodospirillales 204441|Rhodospirillales E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase - - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_898149_1 190486.XAC0830 2.39e-20 89.0 COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,1RZ34@1236|Gammaproteobacteria,1XBX3@135614|Xanthomonadales 135614|Xanthomonadales Q Taurine catabolism dioxygenase TauD, TfdA family tauD - 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_898149_2 198628.Dda3937_02690 4.77e-50 169.0 COG1794@1|root,COG1794@2|Bacteria,1QEFX@1224|Proteobacteria,1S0ER@1236|Gammaproteobacteria,2JEWD@204037|Dickeya 1236|Gammaproteobacteria M Asp/Glu/Hydantoin racemase - - 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race k59_532083_1 1282876.BAOK01000001_gene2771 1.39e-09 63.5 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,2U68V@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_1158581_2 436308.Nmar_0748 2e-56 192.0 COG0480@1|root,arCOG01559@2157|Archaea,41S9B@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K03234 ko04152,ko04921,map04152,map04921 - - - ko00000,ko00001,ko03012,ko04147 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_796407_2 33898.JRHJ01000042_gene3518 2.11e-24 101.0 COG2030@1|root,COG2030@2|Bacteria,2GJJI@201174|Actinobacteria 201174|Actinobacteria I dehydratase - - - - - - - - - - - - MaoC_dehydrat_N,MaoC_dehydratas k59_639492_1 69395.JQLZ01000003_gene57 1.94e-30 128.0 COG1506@1|root,COG1506@2|Bacteria,1N75C@1224|Proteobacteria,2TVNG@28211|Alphaproteobacteria,2KHPF@204458|Caulobacterales 204458|Caulobacterales E Prolyl oligopeptidase family - - - - - - - - - - - - PD40,Peptidase_S9 k59_271259_1 493475.GARC_0029 1.67e-53 175.0 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,464J3@72275|Alteromonadaceae 1236|Gammaproteobacteria J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_271259_2 768671.ThimaDRAFT_2723 6.46e-87 261.0 COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1WWJX@135613|Chromatiales 135613|Chromatiales F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions - - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like k59_324008_2 313625.BL107_11271 2.5e-39 141.0 COG3637@1|root,COG3637@2|Bacteria,1G4TB@1117|Cyanobacteria,1GZBC@1129|Synechococcus 1117|Cyanobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - Phenol_MetA_deg k59_584364_1 1411685.U062_01779 3.6e-32 121.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1J4D2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006015,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042301,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046391,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b1207,iAPECO1_1312.APECO1_323,iB21_1397.B21_01192,iBWG_1329.BWG_1032,iE2348C_1286.E2348C_1330,iEC042_1314.EC042_1264,iEC55989_1330.EC55989_1303,iECABU_c1320.ECABU_c14780,iECBD_1354.ECBD_2414,iECB_1328.ECB_01182,iECDH10B_1368.ECDH10B_1260,iECDH1ME8569_1439.ECDH1ME8569_1146,iECD_1391.ECD_01182,iECED1_1282.ECED1_1355,iECH74115_1262.ECH74115_1688,iECIAI1_1343.ECIAI1_1228,iECIAI39_1322.ECIAI39_1543,iECNA114_1301.ECNA114_1372,iECO103_1326.ECO103_1309,iECO111_1330.ECO111_1536,iECO26_1355.ECO26_1720,iECOK1_1307.ECOK1_1360,iECP_1309.ECP_1255,iECS88_1305.ECS88_1275,iECSE_1348.ECSE_1257,iECSF_1327.ECSF_1183,iECSP_1301.ECSP_1597,iECUMN_1333.ECUMN_1504,iECW_1372.ECW_m1293,iECs_1301.ECs1712,iEKO11_1354.EKO11_2647,iETEC_1333.ETEC_1311,iEcDH1_1363.EcDH1_2440,iEcE24377_1341.EcE24377A_1355,iEcHS_1320.EcHS_A1312,iEcSMS35_1347.EcSMS35_1935,iEcolC_1368.EcolC_2419,iG2583_1286.G2583_1478,iJO1366.b1207,iJR904.b1207,iLF82_1304.LF82_1744,iNRG857_1313.NRG857_06180,iSBO_1134.SBO_1860,iSDY_1059.SDY_1256,iSSON_1240.SSON_1971,iUMN146_1321.UM146_11025,iUMNK88_1353.UMNK88_1523,iUTI89_1310.UTI89_C1401,iWFL_1372.ECW_m1293,iY75_1357.Y75_RS06300,ic_1306.c1665 Pribosyl_synth,Pribosyltran_N k59_584364_2 1379698.RBG1_1C00001G0172 1.43e-45 159.0 COG1825@1|root,COG1825@2|Bacteria,2NPVU@2323|unclassified Bacteria 2|Bacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_584364_3 670307.HYPDE_36158 4e-21 90.1 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2TT6Q@28211|Alphaproteobacteria,3N6TR@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_1368093_1 1177154.Y5S_03514 4.68e-10 65.1 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1XIW5@135619|Oceanospirillales 135619|Oceanospirillales NU Tfp pilus assembly protein - - - ko:K08086 - - - - ko00000 - - - LysM,TPR_19 k59_427870_1 1380394.JADL01000001_gene2044 3.56e-64 205.0 COG0601@1|root,COG0601@2|Bacteria,1MWXF@1224|Proteobacteria,2TR7C@28211|Alphaproteobacteria,2JQ7B@204441|Rhodospirillales 204441|Rhodospirillales EP Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_427870_2 1380394.JADL01000001_gene2045 5.6e-42 148.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2TUWG@28211|Alphaproteobacteria,2JQ92@204441|Rhodospirillales 204441|Rhodospirillales EP N-terminal TM domain of oligopeptide transport permease C - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_1521532_1 2340.JV46_14280 2.09e-198 561.0 COG1156@1|root,COG1156@2|Bacteria,1QUQE@1224|Proteobacteria,1T210@1236|Gammaproteobacteria,1JC0C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit - - - - - - - - - - - - ATP-synt_ab k59_1521532_2 768671.ThimaDRAFT_4705 1.37e-32 128.0 COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria,1WWCP@135613|Chromatiales 135613|Chromatiales F Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit - - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_949605_1 999141.GME_05050 2.65e-86 260.0 COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,1RQAV@1236|Gammaproteobacteria,1XJCN@135619|Oceanospirillales 135619|Oceanospirillales T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_1368100_1 1167006.UWK_00037 1.62e-89 275.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,42MYT@68525|delta/epsilon subdivisions,2WM6R@28221|Deltaproteobacteria,2MI10@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_271274_1 1121396.KB893012_gene4105 5.36e-18 80.9 COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,42T27@68525|delta/epsilon subdivisions,2WPTI@28221|Deltaproteobacteria,2MKXJ@213118|Desulfobacterales 28221|Deltaproteobacteria I MaoC like domain - - - - - - - - - - - - MaoC_dehydratas k59_271274_2 1122611.KB904018_gene7089 2.74e-35 129.0 COG0778@1|root,COG0778@2|Bacteria,2HI8Q@201174|Actinobacteria,4EHDQ@85012|Streptosporangiales 201174|Actinobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_898181_2 436308.Nmar_0403 1.73e-47 158.0 COG2019@1|root,arCOG01039@2157|Archaea,41SK7@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the archaeal adenylate kinase family adkA - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AAA_17 k59_271276_1 226185.EF_2181 1.75e-10 67.8 COG1215@1|root,COG1216@1|root,COG2230@1|root,COG1215@2|Bacteria,COG1216@2|Bacteria,COG2230@2|Bacteria,1V06G@1239|Firmicutes,4ISXV@91061|Bacilli,4B6QG@81852|Enterococcaceae 91061|Bacilli M Methionine biosynthesis protein MetW - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2,Methyltransf_23 k59_845768_2 1415780.JPOG01000001_gene431 1.6e-49 163.0 COG3791@1|root,COG3791@2|Bacteria,1N2V8@1224|Proteobacteria,1SCP1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_584384_1 1238450.VIBNISOn1_1630004 1.82e-63 203.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,1RPJM@1236|Gammaproteobacteria,1XZ3B@135623|Vibrionales 135623|Vibrionales L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_639526_1 444860.E3SJ27_9CAUD 1.82e-85 273.0 4QERI@10239|Viruses,4QYA1@35237|dsDNA viruses no RNA stage,4QS5A@28883|Caudovirales,4QIAY@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_64983_1 1245471.PCA10_23770 4.65e-76 228.0 COG0346@1|root,COG0346@2|Bacteria,1RI3Q@1224|Proteobacteria 1224|Proteobacteria E glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_639557_1 1110502.TMO_3079 3.03e-24 97.1 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2TSW8@28211|Alphaproteobacteria,2JR32@204441|Rhodospirillales 204441|Rhodospirillales O Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm k59_639557_2 1116472.MGMO_41c00610 2.38e-07 49.3 COG3114@1|root,COG3114@2|Bacteria,1NGBM@1224|Proteobacteria,1SGGH@1236|Gammaproteobacteria,1XFW4@135618|Methylococcales 135618|Methylococcales U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes - - - ko:K02196 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.107 - - CcmD k59_639557_3 1454004.AW11_02930 8.53e-21 87.0 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,1KQQX@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE - - ko:K02197 - - - - ko00000 - - - CcmE k59_532142_1 3218.PP1S9122_1V6.1 3.26e-29 117.0 COG2897@1|root,KOG1529@2759|Eukaryota 2759|Eukaryota P thiosulfate sulfurtransferase activity MST - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - DUF1930,Rhodanese k59_65003_1 1469245.JFBG01000001_gene489 5.15e-138 407.0 COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,1RZ0U@1236|Gammaproteobacteria,1WW7B@135613|Chromatiales 135613|Chromatiales C reductase, alpha subunit - - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2 k59_1368134_1 1229909.NSED_07410 3.6e-107 331.0 COG0189@1|root,COG0624@1|root,arCOG01107@2157|Archaea,arCOG01589@2157|Archaea 2157|Archaea HJ COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) rimK - 3.4.17.11,3.5.1.18,6.3.2.2,6.3.2.4 ko:K01295,ko:K01439,ko:K01919,ko:K01921,ko:K05844 ko00270,ko00300,ko00473,ko00480,ko00550,ko01100,ko01120,ko01230,ko01502,map00270,map00300,map00473,map00480,map00550,map01100,map01120,map01230,map01502 M00016,M00118 R00894,R01150,R02734,R10993 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko03009 - - - M20_dimer,Peptidase_M20,RimK k59_427917_1 864051.BurJ1DRAFT_2578 2.85e-19 89.7 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2VH1Q@28216|Betaproteobacteria,1KKA7@119065|unclassified Burkholderiales 28216|Betaproteobacteria C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_1629554_1 335543.Sfum_0590 3.91e-22 94.0 2BQW2@1|root,32JT0@2|Bacteria,1QNFB@1224|Proteobacteria,432XH@68525|delta/epsilon subdivisions,2WYDA@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1158646_1 436308.Nmar_0065 5.08e-87 265.0 COG2219@1|root,arCOG03013@2157|Archaea,41SCD@651137|Thaumarchaeota 651137|Thaumarchaeota L Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair priL - - ko:K18882 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DNA_primase_lrg k59_639570_1 1333856.L686_04500 8e-98 321.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1Z0YX@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L helicase lhr GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,HTH_42,Helicase_C k59_949652_2 1027273.GZ77_13985 7.25e-77 242.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,1XHYN@135619|Oceanospirillales 135619|Oceanospirillales D Reduces the stability of FtsZ polymers in the presence of ATP zapE - - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_532162_1 1123321.KB905818_gene4911 3.8e-16 78.6 COG0454@1|root,COG0454@2|Bacteria,2HGQP@201174|Actinobacteria 201174|Actinobacteria K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 k59_324084_1 1485545.JQLW01000005_gene1137 1.56e-14 68.2 COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria 1224|Proteobacteria J Belongs to the bacterial ribosomal protein bS21 family rpsU GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 k59_375886_2 1071085.KK033114_gene424 1.57e-17 81.6 COG2030@1|root,arCOG00776@2157|Archaea,2XWQH@28890|Euryarchaeota,23V9J@183963|Halobacteria 183963|Halobacteria I Acyl dehydratase - - - - - - - - - - - - MaoC_dehydratas k59_1522043_1 445696.E3SSW6_9CAUD 4.38e-44 169.0 4QAZ6@10239|Viruses,4QUU8@35237|dsDNA viruses no RNA stage,4QPHV@28883|Caudovirales,4QI4H@10662|Myoviridae 10662|Myoviridae S Phage tail sheath protein - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098027 - - - - - - - - - - - k59_4975_1 553385.JEMF01000010_gene2342 1.8e-16 79.0 COG0235@1|root,COG0235@2|Bacteria,1RE8T@1224|Proteobacteria,1S3UF@1236|Gammaproteobacteria,1XJJH@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) mtnB - 4.1.1.104,4.2.1.109 ko:K08964,ko:K22130 ko00270,ko01100,map00270,map01100 M00034 R07392 RC01939 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II k59_4975_2 686340.Metal_3599 2.89e-84 253.0 COG1791@1|root,COG1791@2|Bacteria,1RCZD@1224|Proteobacteria,1S42U@1236|Gammaproteobacteria,1XF09@135618|Methylococcales 135618|Methylococcales S Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway mtnD - 1.13.11.53,1.13.11.54 ko:K08967 ko00270,ko01100,map00270,map01100 M00034 R07363,R07364 RC01866,RC02018,RC02118 ko00000,ko00001,ko00002,ko01000 - - - ARD k59_585214_1 441620.Mpop_1126 1.12e-28 110.0 COG4319@1|root,COG4319@2|Bacteria,1RD4M@1224|Proteobacteria,2UA09@28211|Alphaproteobacteria,1JV58@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3225) MA20_22680 - - - - - - - - - - - DUF3225 k59_955846_1 1267533.KB906733_gene3403 1.54e-51 170.0 COG2102@1|root,COG2102@2|Bacteria,3Y46Z@57723|Acidobacteria,2JIS5@204432|Acidobacteriia 204432|Acidobacteriia S Diphthamide synthase - - - - - - - - - - - - Diphthami_syn_2 k59_538135_1 436308.Nmar_0312 3.33e-26 104.0 COG0142@1|root,arCOG01726@2157|Archaea,41SEV@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the FPP GGPP synthase family - - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13787 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00365 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_538135_2 768704.Desmer_0900 3.24e-17 80.1 COG2518@1|root,COG2518@2|Bacteria,1V4CK@1239|Firmicutes,24IE0@186801|Clostridia,262KA@186807|Peptococcaceae 186801|Clostridia J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_647714_1 999541.bgla_2g21610 1.45e-23 96.7 COG0625@1|root,COG0625@2|Bacteria,1MXHH@1224|Proteobacteria,2VH95@28216|Betaproteobacteria,1K5ZQ@119060|Burkholderiaceae 28216|Betaproteobacteria O Belongs to the GST superfamily gstA - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_3,GST_N,GST_N_3 k59_647714_2 96561.Dole_1585 3.94e-10 61.6 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,42ME9@68525|delta/epsilon subdivisions,2WKF0@28221|Deltaproteobacteria,2MHW2@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_1582781_1 1238450.VIBNISOn1_1010019 5.31e-17 80.1 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1XT9F@135623|Vibrionales 135623|Vibrionales V Transport permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_1582781_2 1304275.C41B8_10148 3.07e-40 141.0 COG0084@1|root,COG0084@2|Bacteria,1MXN8@1224|Proteobacteria,1RNCC@1236|Gammaproteobacteria 1236|Gammaproteobacteria L 3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair tatD GO:0000175,GO:0000302,GO:0000738,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009056,GO:0009057,GO:0009636,GO:0009987,GO:0010035,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046700,GO:0046872,GO:0050896,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901700 - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_851970_1 1120956.JHZK01000032_gene108 1.83e-12 67.4 COG0664@1|root,COG0664@2|Bacteria,1RI6M@1224|Proteobacteria,2VB88@28211|Alphaproteobacteria,1JPKA@119043|Rhodobiaceae 28211|Alphaproteobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_434243_1 29581.BW37_00234 1.37e-49 169.0 COG0715@1|root,COG0715@2|Bacteria,1MWJF@1224|Proteobacteria,2VKMA@28216|Betaproteobacteria,473SN@75682|Oxalobacteraceae 28216|Betaproteobacteria P ABC-type nitrate sulfonate bicarbonate transport system, periplasmic component - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1_2 k59_73061_1 1123252.ATZF01000002_gene2274 2.23e-25 100.0 COG0454@1|root,COG0454@2|Bacteria 2|Bacteria K -acetyltransferase wecD GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747 2.3.1.210 ko:K16704 - - - - ko00000,ko01000 - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_804759_1 626887.J057_22770 6.45e-08 54.3 2B4XH@1|root,32REP@2|Bacteria,1RJ9F@1224|Proteobacteria,1T0SV@1236|Gammaproteobacteria,46BPI@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_804759_2 1232410.KI421425_gene1550 1.62e-77 250.0 COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,42Z0Q@68525|delta/epsilon subdivisions,2WU0G@28221|Deltaproteobacteria,43T6R@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_488892_2 502025.Hoch_4153 1.3e-25 107.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YUJ9@29|Myxococcales 28221|Deltaproteobacteria T Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_1428793_1 247490.KSU1_D0861 9.34e-47 166.0 COG0612@1|root,COG0612@2|Bacteria,2IYKK@203682|Planctomycetes 203682|Planctomycetes S PFAM Peptidase M16 inactive domain - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_330243_1 557599.MKAN_23395 3e-63 198.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 k59_1428798_1 330214.NIDE0429 1.21e-09 58.5 2C1IB@1|root,2ZG3S@2|Bacteria 2|Bacteria S Proto-chlorophyllide reductase 57 kD subunit - - - - - - - - - - - - PCP_red k59_1428798_2 1122217.KB899594_gene1327 6.17e-08 54.7 COG0328@1|root,COG3341@1|root,COG0328@2|Bacteria,COG3341@2|Bacteria,1V442@1239|Firmicutes,4H4KD@909932|Negativicutes 909932|Negativicutes L RNase H rnhA - - ko:K06993 - - - - ko00000 - - - Cauli_VI,RNase_H k59_1582798_1 314278.NB231_08132 1.77e-95 310.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_73076_1 1187851.A33M_4388 1.83e-76 237.0 COG0034@1|root,COG0034@2|Bacteria,1MWHP@1224|Proteobacteria,2U06H@28211|Alphaproteobacteria 28211|Alphaproteobacteria F glutamine amidotransferase glxB - 2.1.1.21 ko:K22081 ko00680,ko01120,map00680,map01120 - R01586 RC00554 ko00000,ko00001,ko01000 - - - GATase_6 k59_383440_1 1444711.CCJF01000003_gene91 4.1e-61 206.0 COG0058@1|root,COG0058@2|Bacteria,2JFEH@204428|Chlamydiae 204428|Chlamydiae G Carbohydrate phosphorylase glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_1220304_1 330214.NIDE1344 4.04e-71 230.0 COG1508@1|root,COG1508@2|Bacteria,3J0AT@40117|Nitrospirae 40117|Nitrospirae K Sigma-54 factor, Activator interacting domain (AID) rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_804779_1 330214.NIDE1815 7.78e-71 218.0 COG1310@1|root,COG1310@2|Bacteria,3J0U8@40117|Nitrospirae 40117|Nitrospirae S JAB/MPN domain - - 3.13.1.6 ko:K21140 ko04122,map04122 - R11524 RC00064,RC00090 ko00000,ko00001,ko01000 - - - Prok-JAB k59_851994_1 522306.CAP2UW1_2215 3.17e-67 229.0 COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2WGGY@28216|Betaproteobacteria 28216|Betaproteobacteria V ABC-type multidrug transport system ATPase component yhiH - - ko:K13926 - - - - ko00000 - - - ABC2_membrane_3,ABC_tran k59_851994_2 522306.CAP2UW1_2214 4.01e-13 69.3 COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,2VHRI@28216|Betaproteobacteria 28216|Betaproteobacteria V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_1374223_2 1292020.H483_0109745 0.0007 41.2 COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria 201174|Actinobacteria Q N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 k59_73101_1 996637.SGM_4003 1.26e-19 90.9 COG3173@1|root,COG3173@2|Bacteria,2GJT0@201174|Actinobacteria 201174|Actinobacteria S Aminoglycoside phosphotransferase - - - - - - - - - - - - APH k59_434281_1 573370.DMR_23340 3.37e-50 185.0 COG4262@1|root,COG4262@2|Bacteria,1QX9D@1224|Proteobacteria,42Q62@68525|delta/epsilon subdivisions,2WMHX@28221|Deltaproteobacteria,2M99V@213115|Desulfovibrionales 28221|Deltaproteobacteria E Spermine/spermidine synthase domain - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_1113371_1 95619.PM1_0206680 6.04e-106 333.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1636631_1 1121920.AUAU01000005_gene1045 2.04e-120 353.0 COG0329@1|root,COG0329@2|Bacteria,3Y8R8@57723|Acidobacteria 57723|Acidobacteria EM Dihydrodipicolinate synthetase family - - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_647782_1 1120983.KB894570_gene1437 7.79e-51 171.0 COG2113@1|root,COG2113@2|Bacteria,1MVXS@1224|Proteobacteria,2TSFK@28211|Alphaproteobacteria 28211|Alphaproteobacteria E ABC-type proline glycine betaine transport systems, periplasmic components - - - ko:K02002 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - OpuAC k59_1274600_1 1121035.AUCH01000019_gene2862 6.29e-07 58.2 COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,2VVFV@28216|Betaproteobacteria,2KWMY@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4115) - - - ko:K15539 - - - - ko00000 - - - DUF4115,HTH_25 k59_1428845_1 880073.Calab_0956 1.73e-31 120.0 COG2103@1|root,COG2103@2|Bacteria,2NP6Y@2323|unclassified Bacteria 2|Bacteria S Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate murQ GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006040,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009254,GO:0016787,GO:0016801,GO:0016803,GO:0016829,GO:0016835,GO:0030203,GO:0043170,GO:0046348,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901575 4.2.1.126 ko:K07106 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - iECH74115_1262.ECH74115_3658,iECSP_1301.ECSP_3375,iECs_1301.ECs3299,iG2583_1286.G2583_2959 SIS,SIS_2 k59_225171_1 751945.Theos_1506 1.52e-37 144.0 COG0474@1|root,COG0474@2|Bacteria,1WICW@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P ATPase P-type (Transporting), HAD superfamily, subfamily IC pacL - 3.6.3.6,3.6.3.8 ko:K01535,ko:K01537 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.3.2,3.A.3.3 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_170820_1 856793.MICA_2282 3.78e-50 176.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2TRN0@28211|Alphaproteobacteria,4BP9V@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_1482536_1 251229.Chro_0877 2.5e-11 65.1 COG1132@1|root,COG1132@2|Bacteria,1G1JY@1117|Cyanobacteria,3VINJ@52604|Pleurocapsales 1117|Cyanobacteria V ABC-type multidrug transport system ATPase and permease - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1482536_2 1279017.AQYJ01000026_gene73 1.7e-11 67.8 2DXTJ@1|root,346GW@2|Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - k59_277793_1 1288826.MSNKSG1_06563 1.03e-99 299.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,46517@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_2469,iEC55989_1330.EC55989_2573,iECO103_1326.ECO103_2794,iECO111_1330.ECO111_3077,iECO26_1355.ECO26_3317,iECSE_1348.ECSE_2638,iECW_1372.ECW_m2518,iEKO11_1354.EKO11_1436,iSSON_1240.SSON_2387,iUMNK88_1353.UMNK88_2882,iWFL_1372.ECW_m2518 Chorismate_synt k59_434311_1 1286631.X805_37510 3.41e-07 53.9 COG4307@1|root,COG4307@2|Bacteria,1MW31@1224|Proteobacteria,2VMRJ@28216|Betaproteobacteria,1KKIA@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Putative zinc-binding metallo-peptidase - - - - - - - - - - - - Peptidase_Mx,zinc-ribbon_6 k59_434311_2 1209072.ALBT01000066_gene1094 2.14e-41 148.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1FGDP@10|Cellvibrio 1236|Gammaproteobacteria S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_1636652_1 196162.Noca_4919 8.65e-07 55.5 COG0500@1|root,COG2226@2|Bacteria,2GM2N@201174|Actinobacteria,4DR5V@85009|Propionibacteriales 201174|Actinobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_1008340_1 118168.MC7420_7906 3.21e-49 176.0 COG2304@1|root,COG2304@2|Bacteria,1GQAG@1117|Cyanobacteria,1H979@1150|Oscillatoriales 1117|Cyanobacteria T protein containing a von Willebrand factor type A (vWA) domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_488966_1 1125863.JAFN01000001_gene3005 1.36e-36 133.0 COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria 1224|Proteobacteria D sister chromatid segregation - - - - - - - - - - - - - k59_1220369_1 1344012.ATMI01000041_gene271 6.2e-05 50.4 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RPX4@1236|Gammaproteobacteria,4BUNZ@82986|Tatumella 1236|Gammaproteobacteria E Amino acid permease yveA - - ko:K19540 - - - - ko00000,ko02000 2.A.3.8.17 - - AA_permease_2 k59_330305_1 1123226.KB899280_gene2154 8.55e-56 190.0 COG3842@1|root,COG3842@2|Bacteria,1TPW2@1239|Firmicutes,4HD3J@91061|Bacilli,274ER@186822|Paenibacillaceae 91061|Bacilli E Belongs to the ABC transporter superfamily phnT - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 k59_170842_1 298655.KI912266_gene6070 1.54e-87 274.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4EU6F@85013|Frankiales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1061433_1 1131553.JIBI01000013_gene926 1.95e-48 157.0 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,2VR9B@28216|Betaproteobacteria,37350@32003|Nitrosomonadales 28216|Betaproteobacteria E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH k59_1061433_2 631362.Thi970DRAFT_01570 1.56e-21 86.7 COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,1S8R4@1236|Gammaproteobacteria,1WYHH@135613|Chromatiales 135613|Chromatiales E phosphoribosyl-ATP pyrophosphohydrolase hisE - 3.6.1.31 ko:K01523 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - PRA-PH k59_648885_1 436308.Nmar_1388 4.26e-183 521.0 COG1032@1|root,arCOG01357@2157|Archaea,41SCX@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - - - - - - - - - - - Radical_SAM k59_1164469_1 1380394.JADL01000009_gene3328 2.14e-12 71.6 COG2519@1|root,COG2519@2|Bacteria,1R2V1@1224|Proteobacteria,2TZRX@28211|Alphaproteobacteria,2JZ5N@204441|Rhodospirillales 204441|Rhodospirillales J Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21 k59_539072_1 857087.Metme_0746 2.02e-28 105.0 2C1YJ@1|root,32ZXK@2|Bacteria,1N98H@1224|Proteobacteria,1SD8N@1236|Gammaproteobacteria,1XFAR@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF2782) - - - - - - - - - - - - DUF2782 k59_539072_3 1177154.Y5S_01415 1.35e-20 90.9 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1XI0Q@135619|Oceanospirillales 135619|Oceanospirillales P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_384677_1 1535422.ND16A_2998 2.72e-09 59.3 COG1226@1|root,32Y28@2|Bacteria,1NEAT@1224|Proteobacteria,1S588@1236|Gammaproteobacteria,2Q6SK@267889|Colwelliaceae 1236|Gammaproteobacteria P Ion channel - - - - - - - - - - - - Ion_trans_2 k59_384677_2 246196.MSMEI_1543 6.41e-16 75.9 COG5517@1|root,COG5517@2|Bacteria,2IIIU@201174|Actinobacteria,239FN@1762|Mycobacteriaceae 201174|Actinobacteria Q SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_490087_1 604331.AUHY01000118_gene12 2.02e-26 109.0 COG1850@1|root,COG1850@2|Bacteria 2|Bacteria G ribulose-bisphosphate carboxylase activity mtnW - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large k59_490087_2 1122185.N792_04775 7.23e-12 65.1 COG2954@1|root,COG2954@2|Bacteria,1RI38@1224|Proteobacteria,1S77V@1236|Gammaproteobacteria,1X64C@135614|Xanthomonadales 135614|Xanthomonadales S CYTH domain protein - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CYTH k59_384682_1 1415778.JQMM01000001_gene1636 6.08e-22 99.8 COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria,1J6HF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E ABC-type oligopeptide transport system, periplasmic component oppA - - ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 k59_384682_2 1101189.AQUO01000002_gene710 3.98e-10 64.7 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TTN3@28211|Alphaproteobacteria,2PURK@265|Paracoccus 28211|Alphaproteobacteria EP Binding-protein-dependent transport system inner membrane component oppB - - ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 k59_1221392_1 330214.NIDE3712 2.8e-74 231.0 COG0330@1|root,COG0330@2|Bacteria 2|Bacteria O stress-induced mitochondrial fusion hflC GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564 - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_435350_1 765914.ThisiDRAFT_0399 3.5e-153 446.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales 135613|Chromatiales O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1429954_1 378806.STAUR_0941 5.19e-61 201.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,42N8B@68525|delta/epsilon subdivisions,2WJ6I@28221|Deltaproteobacteria,2YUV1@29|Myxococcales 28221|Deltaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_1275823_1 1236508.BAKF01000094_gene2667 8.25e-05 52.4 COG3209@1|root,COG3209@2|Bacteria,4NXFH@976|Bacteroidetes,2FZ63@200643|Bacteroidia 976|Bacteroidetes M RHS repeat-associated core domain protein - - - - - - - - - - - - - k59_74278_1 1453501.JELR01000001_gene2223 1.75e-46 162.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria,464BG@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG0331 (acyl-carrier-protein) S-malonyltransferase fabD GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - iEcE24377_1341.EcE24377A_1213,iJN746.PP_1913,iPC815.YPO1598 Acyl_transf_1 k59_748153_2 1121015.N789_08055 1.12e-29 121.0 COG1075@1|root,COG1075@2|Bacteria,1PHER@1224|Proteobacteria,1T7T0@1236|Gammaproteobacteria,1X9P7@135614|Xanthomonadales 135614|Xanthomonadales S Lecithin:cholesterol acyltransferase - - - - - - - - - - - - LCAT k59_7879_1 1254432.SCE1572_10165 3.41e-53 181.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,43AKW@68525|delta/epsilon subdivisions,2X60Z@28221|Deltaproteobacteria,2Z385@29|Myxococcales 28221|Deltaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_7879_2 1121918.ARWE01000001_gene1274 4.74e-28 110.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42QPJ@68525|delta/epsilon subdivisions,2WMNM@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP cheR40H-1 - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_1327900_1 1286106.MPL1_07792 5.87e-111 330.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,45ZQ6@72273|Thiotrichales 72273|Thiotrichales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_502219_1 391625.PPSIR1_29760 3.5e-38 137.0 COG0278@1|root,COG0316@1|root,COG0607@1|root,COG0278@2|Bacteria,COG0316@2|Bacteria,COG0607@2|Bacteria,1MZ4V@1224|Proteobacteria,43154@68525|delta/epsilon subdivisions,2WWCI@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Belongs to the glutaredoxin family. Monothiol subfamily - - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin,Rhodanese k59_502219_2 1333998.M2A_1982 3.99e-131 383.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2TQUY@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B k59_1288151_1 438753.AZC_3588 4.48e-47 169.0 28MSK@1|root,2ZB0X@2|Bacteria,1R7CY@1224|Proteobacteria,2U2MY@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Bacteriophage head to tail connecting protein - - - - - - - - - - - - Head-tail_con k59_661081_1 748280.NH8B_0235 1.87e-63 207.0 COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2VI6V@28216|Betaproteobacteria,2KPJZ@206351|Neisseriales 206351|Neisseriales F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_1533452_1 472759.Nhal_0556 1.46e-46 165.0 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,1WX3X@135613|Chromatiales 135613|Chromatiales N PFAM ABC-type uncharacterised transport system - - - - - - - - - - - - ABC_transp_aux k59_1288166_1 580340.Tlie_1573 1.06e-06 55.8 COG0451@1|root,COG0451@2|Bacteria,3TAV7@508458|Synergistetes 508458|Synergistetes M PFAM NAD-dependent epimerase dehydratase - - 5.1.3.7 ko:K02473 ko00520,ko01100,map00520,map01100 - R00418 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_287846_1 436308.Nmar_0043 4.83e-124 363.0 COG0392@1|root,arCOG00899@2157|Archaea,41SFV@651137|Thaumarchaeota 651137|Thaumarchaeota S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_1383310_1 1229909.NSED_05035 5.74e-41 139.0 arCOG10564@1|root,arCOG10564@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_965597_1 1454004.AW11_01808 7.6e-97 295.0 COG0451@1|root,COG0451@2|Bacteria,1MU1A@1224|Proteobacteria,2VHGA@28216|Betaproteobacteria 28216|Betaproteobacteria M PFAM NAD-dependent epimerase dehydratase - - 1.1.1.410 ko:K22025 - - - - ko00000,ko01000 - - - Epimerase k59_661128_1 641524.ADICYQ_5267 1.77e-13 70.5 COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,4NDV1@976|Bacteroidetes,47JGM@768503|Cytophagia 976|Bacteroidetes G COGs COG2133 Glucose sorbosone dehydrogenase - - - - - - - - - - - - Cytochrome_CBB3,GSDH k59_661128_2 927658.AJUM01000022_gene1009 1.9e-40 141.0 COG0545@1|root,COG0545@2|Bacteria,4NDW4@976|Bacteroidetes,2G31Y@200643|Bacteroidia,3XIKP@558415|Marinilabiliaceae 976|Bacteroidetes O Domain amino terminal to FKBP-type peptidyl-prolyl isomerase - - 5.2.1.8 ko:K03772,ko:K03773 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N k59_1018346_1 1499967.BAYZ01000105_gene3517 3.44e-13 75.1 COG2755@1|root,COG2755@2|Bacteria,2NR42@2323|unclassified Bacteria 2|Bacteria E lipolytic protein G-D-S-L family - - 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - ChitinaseA_N,Lipase_GDSL_2 k59_340161_1 391615.ABSJ01000054_gene1467 9.32e-54 175.0 COG3417@1|root,COG3417@2|Bacteria,1RA6V@1224|Proteobacteria,1S4SE@1236|Gammaproteobacteria,1JAIZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Peptidoglycan-synthase activator LpoB - - - ko:K07337 - - - - ko00000 - - - LpoB k59_340161_2 391615.ABSJ01000054_gene1466 9.93e-39 137.0 2EUFJ@1|root,33MXU@2|Bacteria,1NZHB@1224|Proteobacteria,1SQC7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S LPP20 lipoprotein - - - - - - - - - - - - LPP20 k59_1533481_1 1589733.A0A0C5AAW8_9CAUD 9.39e-09 66.6 4QBUC@10239|Viruses,4QQGQ@28883|Caudovirales,4QHY3@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_178601_1 444860.E3SJA0_9CAUD 5.64e-64 206.0 4QBQH@10239|Viruses,4QZ5U@35237|dsDNA viruses no RNA stage,4QU2Y@28883|Caudovirales,4QJJN@10662|Myoviridae 10662|Myoviridae S galactoside 2-alpha-L-fucosyltransferase activity - - - - - - - - - - - - - k59_289071_1 1178825.ALIH01000018_gene1140 1.27e-16 85.1 COG1409@1|root,COG3209@1|root,COG1409@2|Bacteria,COG3209@2|Bacteria,4NGK2@976|Bacteroidetes,1I0BV@117743|Flavobacteriia 976|Bacteroidetes M Purple acid Phosphatase, N-terminal domain - - - - - - - - - - - - Metallophos,Pur_ac_phosph_N k59_863007_1 665956.HMPREF1032_00855 1.07e-62 203.0 COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24E75@186801|Clostridia,3WPCX@541000|Ruminococcaceae 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D k59_87425_1 314278.NB231_07647 1.01e-76 239.0 COG0508@1|root,COG0508@2|Bacteria,1MVDC@1224|Proteobacteria,1RQ9Y@1236|Gammaproteobacteria,1WZYE@135613|Chromatiales 135613|Chromatiales C 2-oxoacid dehydrogenases acyltransferase (catalytic domain) - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1233358_1 1122603.ATVI01000005_gene3264 2.42e-63 211.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) amdA - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_289083_1 1193181.BN10_130032 1.62e-14 78.6 COG1640@1|root,COG1640@2|Bacteria,2GM5Z@201174|Actinobacteria,4FE74@85021|Intrasporangiaceae 201174|Actinobacteria G 4-alpha-glucanotransferase malQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_503610_1 379066.GAU_3099 1.13e-70 236.0 COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,1ZUF5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1124518_1 580332.Slit_1447 2.44e-67 223.0 COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,2WHYC@28216|Betaproteobacteria,44WNC@713636|Nitrosomonadales 1224|Proteobacteria C heat shock protein binding - - - - - - - - - - - - Cytochrom_CIII,Cytochrom_c3_2,Cytochrome_C7 k59_966531_2 323261.Noc_1776 1.06e-84 256.0 COG0225@1|root,COG0225@2|Bacteria,1R33Z@1224|Proteobacteria,1T62V@1236|Gammaproteobacteria,1X277@135613|Chromatiales 135613|Chromatiales O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine - - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_1328887_1 1123393.KB891333_gene2556 1.04e-30 119.0 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2VJ5G@28216|Betaproteobacteria,1KRK3@119069|Hydrogenophilales 119069|Hydrogenophilales M Glycosyl transferase family 2 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 k59_341313_1 290397.Adeh_2968 5.84e-07 52.4 COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,1P6RE@1224|Proteobacteria,43A2M@68525|delta/epsilon subdivisions,2X1XW@28221|Deltaproteobacteria,2YX2T@29|Myxococcales 28221|Deltaproteobacteria I Acetyl-CoA carboxylase, central region - - - - - - - - - - - - ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans k59_341313_2 463191.SSEG_08319 1.8e-114 345.0 COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria 201174|Actinobacteria I Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta accD2 - - - - - - - - - - - Carboxyl_trans k59_1233370_1 342113.DM82_2478 3.78e-76 238.0 COG0121@1|root,COG0121@2|Bacteria,1PU45@1224|Proteobacteria,2VMQD@28216|Betaproteobacteria,1K3SW@119060|Burkholderiaceae 28216|Betaproteobacteria S glutamine amidotransferase egtC - - - - - - - - - - - GATase_4 k59_1072552_2 472759.Nhal_3697 4.57e-121 355.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_446979_2 1411123.JQNH01000001_gene260 5.18e-135 404.0 COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria 28211|Alphaproteobacteria H glutamate--cysteine ligase gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - GCS2 k59_915819_2 1300345.LF41_1319 3.21e-16 77.0 COG0454@1|root,COG0456@2|Bacteria,1NCMN@1224|Proteobacteria,1SFS0@1236|Gammaproteobacteria,1X7VK@135614|Xanthomonadales 135614|Xanthomonadales K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_10 k59_12985_2 269799.Gmet_2301 1.52e-10 64.3 COG3005@1|root,COG3005@2|Bacteria,1NJY9@1224|Proteobacteria,42XJ4@68525|delta/epsilon subdivisions,2WSQ4@28221|Deltaproteobacteria,43TRS@69541|Desulfuromonadales 28221|Deltaproteobacteria C heme-binding sites - - - - - - - - - - - - Cytochrome_C7 k59_548711_1 1121937.AUHJ01000006_gene2541 7.2e-49 166.0 COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,1S8F8@1236|Gammaproteobacteria,46AQ1@72275|Alteromonadaceae 1236|Gammaproteobacteria S Urate oxidase N-terminal - - - - - - - - - - - - Urate_ox_N k59_1124558_1 1121396.KB893055_gene2629 4.41e-11 69.3 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MICN@213118|Desulfobacterales 28221|Deltaproteobacteria G Pyruvate phosphate dikinase, PEP - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_1124561_1 497965.Cyan7822_2685 3.06e-07 47.8 2BNP3@1|root,32HC4@2|Bacteria,1GJJR@1117|Cyanobacteria,3KIZY@43988|Cyanothece 1117|Cyanobacteria S Manganese-binding polypeptide with L-arginine metabolizing enzyme activity. Component of the core of photosystem II psbY - - ko:K02723 ko00195,ko01100,map00195,map01100 - - - ko00000,ko00001,ko00194 - - - PsbY k59_1497085_1 517417.Cpar_0030 1.38e-23 102.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1FDFY@1090|Chlorobi 1090|Chlorobi C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4_20,Fer4_7,Fer4_9,Pyr_redox_2 k59_819697_1 1415754.JQMK01000013_gene569 2.87e-37 133.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,466SB@72275|Alteromonadaceae 1236|Gammaproteobacteria J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_1650387_1 1185652.USDA257_c42600 3.64e-98 295.0 COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,2TWKE@28211|Alphaproteobacteria,4BCGP@82115|Rhizobiaceae 28211|Alphaproteobacteria E Methylenetetrahydrofolate reductase - - - - - - - - - - - - MTHFR k59_1072617_4 1089111.G8I7V8_9CAUD 3.07e-24 97.4 4QGDB@10239|Viruses,4QZHU@35237|dsDNA viruses no RNA stage,4QSG0@28883|Caudovirales,4QM88@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_1289635_1 1229909.NSED_06405 1.06e-80 256.0 COG0322@1|root,arCOG04753@2157|Archaea,41SX9@651137|Thaumarchaeota 651137|Thaumarchaeota L TIGRFAM excinuclease ABC, C subunit - - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,UVR,UvrC_HhH_N k59_1650410_1 279383.Q5DNA0_9CAUD 3.06e-34 134.0 4QB9T@10239|Viruses,4R0FI@35237|dsDNA viruses no RNA stage,4QQR9@28883|Caudovirales,4QN2W@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_966611_1 1123368.AUIS01000003_gene1765 3.95e-19 89.4 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU General Secretion Pathway protein xcsD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_1593770_1 1144342.PMI40_03375 4.51e-65 211.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,473P1@75682|Oxalobacteraceae 28216|Betaproteobacteria F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_1019267_1 436308.Nmar_0851 1.74e-11 60.8 arCOG10553@1|root,arCOG10553@2157|Archaea,41T8J@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1019267_2 436308.Nmar_0852 6.11e-56 177.0 arCOG08684@1|root,arCOG08684@2157|Archaea,41T7E@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1019267_3 436308.Nmar_0853 1.98e-41 139.0 COG0346@1|root,arCOG02708@2157|Archaea,41SU3@651137|Thaumarchaeota 651137|Thaumarchaeota E Glyoxalase-like domain - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase,Glyoxalase_2 k59_915918_1 323848.Nmul_A1038 5.94e-25 100.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHZW@28216|Betaproteobacteria,372AQ@32003|Nitrosomonadales 28216|Betaproteobacteria O prohibitin homologues - - - - - - - - - - - - Band_7 k59_1124644_1 998674.ATTE01000001_gene4260 8.76e-105 315.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria,45ZW7@72273|Thiotrichales 72273|Thiotrichales M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1442889_1 483219.LILAB_03820 1.53e-66 209.0 COG1595@1|root,COG1595@2|Bacteria,1RBM4@1224|Proteobacteria,42S7N@68525|delta/epsilon subdivisions,2X3DW@28221|Deltaproteobacteria,2YUWD@29|Myxococcales 28221|Deltaproteobacteria K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_134304_1 330214.NIDE4064 9.03e-62 198.0 COG1774@1|root,COG1774@2|Bacteria,3J0MI@40117|Nitrospirae 40117|Nitrospirae S PSP1 C-terminal conserved region - - - - - - - - - - - - PSP1 k59_235834_1 1469245.JFBG01000063_gene2351 6.33e-80 261.0 COG0112@1|root,COG0404@1|root,COG0112@2|Bacteria,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1WWZ0@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_1172628_1 1122201.AUAZ01000014_gene250 3.77e-66 230.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,464K7@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG1643 HrpA-like helicases hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_1534419_1 479434.Sthe_2691 4.97e-194 559.0 COG1523@1|root,COG1523@2|Bacteria,2G86B@200795|Chloroflexi 200795|Chloroflexi G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_235841_1 748247.AZKH_0098 3.71e-50 169.0 COG2020@1|root,COG2020@2|Bacteria,1MUBZ@1224|Proteobacteria,2VJJ4@28216|Betaproteobacteria,2KVCR@206389|Rhodocyclales 206389|Rhodocyclales O Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - - - - - - - - - - ICMT,PEMT k59_548791_1 243231.GSU1866 8.76e-67 218.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,43UHM@69541|Desulfuromonadales 28221|Deltaproteobacteria T SMART Nucleotide binding protein, PINc phoH1 - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_134318_1 671143.DAMO_2078 1.27e-43 155.0 COG1994@1|root,COG1994@2|Bacteria,2NP89@2323|unclassified Bacteria 2|Bacteria S Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 k59_1497182_1 167548.EU98_1805 9.75e-45 166.0 28JA7@1|root,2Z951@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - CotH k59_662705_1 909663.KI867150_gene2017 1.68e-32 120.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2WJ1I@28221|Deltaproteobacteria,2MQ9Z@213462|Syntrophobacterales 28221|Deltaproteobacteria K transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Transcrip_reg k59_662705_2 999141.GME_16122 2.65e-12 66.6 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1XJW7@135619|Oceanospirillales 135619|Oceanospirillales L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_1650471_1 1123399.AQVE01000005_gene1017 1.03e-76 243.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,1RQXJ@1236|Gammaproteobacteria,462TY@72273|Thiotrichales 72273|Thiotrichales P Phosphate ATP-binding cassette transporter - - - - - - - - - - - - BPD_transp_1,DUF3708 k59_1650471_2 1469245.JFBG01000019_gene1147 1.11e-10 62.8 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1WWYU@135613|Chromatiales 135613|Chromatiales P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3333 k59_819785_1 1116472.MGMO_84c00030 1.11e-73 242.0 COG4590@1|root,COG4590@2|Bacteria,1QTTD@1224|Proteobacteria,1T1GK@1236|Gammaproteobacteria,1XEGE@135618|Methylococcales 135618|Methylococcales P PFAM Binding-protein-dependent transport systems inner membrane component - - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_235853_1 754476.Q7A_1515 1.67e-58 192.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,45ZWB@72273|Thiotrichales 72273|Thiotrichales G Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides nagZ - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_608875_1 1137271.AZUM01000001_gene1400 2.36e-103 320.0 COG1232@1|root,COG1232@2|Bacteria,2I2Z5@201174|Actinobacteria,4E1XZ@85010|Pseudonocardiales 201174|Actinobacteria H TIGRFAM squalene-associated FAD-dependent desaturase hopC - - - - - - - - - - - Amino_oxidase k59_608875_2 1306406.ASHX01000002_gene5004 8.49e-11 64.3 COG1562@1|root,COG1562@2|Bacteria,2GNS9@201174|Actinobacteria 201174|Actinobacteria I Squalene phytoene synthase hopE - - - - - - - - - - - SQS_PSY k59_1601318_1 28564.XP_002340112.1 0.000503 47.8 COG0484@1|root,KOG0714@2759|Eukaryota 2759|Eukaryota O protein folding - - - ko:K09530 ko04141,map04141 - - - ko00000,ko00001,ko03110,ko04131 - - - DnaJ,Thioredoxin k59_608885_1 497964.CfE428DRAFT_3647 1.12e-20 94.0 COG1236@1|root,COG1793@1|root,COG1236@2|Bacteria,COG1793@2|Bacteria,46SCR@74201|Verrucomicrobia 74201|Verrucomicrobia L DNA ligase N terminus - - 6.5.1.1,6.5.1.6,6.5.1.7 ko:K07577,ko:K10747 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N,RMMBL k59_608885_2 1047013.AQSP01000098_gene2561 1.34e-35 125.0 COG0432@1|root,COG0432@2|Bacteria,2NPR7@2323|unclassified Bacteria 2|Bacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_1134983_1 436308.Nmar_0430 1.71e-131 376.0 COG1500@1|root,arCOG04187@2157|Archaea,41SC7@651137|Thaumarchaeota 651137|Thaumarchaeota J Shwachman-Bodian-Diamond syndrome (SBDS) protein - - - ko:K14574 ko03008,map03008 - - - ko00000,ko00001,ko03009 - - - SBDS,SBDS_C k59_1134983_2 1229909.NSED_02240 3.39e-35 125.0 COG1097@1|root,arCOG00678@2157|Archaea,41SHV@651137|Thaumarchaeota 651137|Thaumarchaeota J Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome rrp4 - - ko:K03679 ko03018,map03018 M00390,M00391 - - ko00000,ko00001,ko00002,ko03019 - - - KH_1 k59_143941_1 4641.GSMUA_Achr11P03500_001 8.12e-62 212.0 COG0626@1|root,KOG2246@1|root,KOG0053@2759|Eukaryota,KOG2246@2759|Eukaryota,37JB2@33090|Viridiplantae,3GE2X@35493|Streptophyta,3KMI8@4447|Liliopsida 35493|Streptophyta G Protein of unknown function, DUF604 - - - - - - - - - - - - DUF604 k59_98078_1 1291050.JAGE01000001_gene2182 1.57e-70 223.0 COG2801@1|root,COG2801@2|Bacteria,1V8EJ@1239|Firmicutes,24MA4@186801|Clostridia 186801|Clostridia L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_29,HTH_8,rve k59_766000_1 1242864.D187_004835 4.51e-43 149.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,42MBV@68525|delta/epsilon subdivisions,2WIRE@28221|Deltaproteobacteria,2YTYD@29|Myxococcales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_766000_2 118173.KB235914_gene1828 9.99e-18 78.6 COG0089@1|root,COG0089@2|Bacteria,1G7XC@1117|Cyanobacteria,1HC5Z@1150|Oscillatoriales 1117|Cyanobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_766000_3 1122129.AUEF01000011_gene1279 2.06e-12 67.8 COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,4HB01@91061|Bacilli,4GXNT@90964|Staphylococcaceae 91061|Bacilli J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome rplD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_351514_1 471857.Svir_08380 1.16e-104 319.0 COG0277@1|root,COG0277@2|Bacteria,2GKQR@201174|Actinobacteria,4DYBE@85010|Pseudonocardiales 201174|Actinobacteria C PFAM FAD binding domain - - - - - - - - - - - - FAD_binding_4 k59_1541705_1 42256.RradSPS_2030 2.07e-70 231.0 COG1249@1|root,COG1249@2|Bacteria,2GJJK@201174|Actinobacteria 201174|Actinobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_716531_1 706587.Desti_0156 1.9e-17 85.5 COG2605@1|root,COG2605@2|Bacteria,1Q1GI@1224|Proteobacteria,42TJZ@68525|delta/epsilon subdivisions,2WQNP@28221|Deltaproteobacteria 28221|Deltaproteobacteria S GHMP kinases N terminal domain - - 2.7.1.168 ko:K07031 ko00540,map00540 - R09770 RC00002,RC00078 ko00000,ko00001,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_831634_1 330214.NIDE0997 6.54e-120 358.0 COG0028@1|root,COG0028@2|Bacteria,3J0D6@40117|Nitrospirae 40117|Nitrospirae H Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1509062_1 1123279.ATUS01000003_gene556 3.57e-55 191.0 COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,1RPXH@1236|Gammaproteobacteria,1J4F5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Succinate dehydrogenase fumarate reductase flavoprotein subunit - - 1.3.99.33 ko:K17363 ko00340,map00340 - R10330 RC00669 ko00000,ko00001,ko01000 - - - FAD_binding_2,FMN_bind k59_1243197_1 311402.Avi_1909 1.74e-50 177.0 COG3509@1|root,COG3509@2|Bacteria,1QW8F@1224|Proteobacteria,2TWSR@28211|Alphaproteobacteria,4BNV2@82115|Rhizobiaceae 28211|Alphaproteobacteria Q Tannase and feruloyl esterase - - 3.1.1.102 ko:K21105 - - R11541 RC00020,RC00041 ko00000,ko01000 - - - Tannase k59_1083005_1 1304888.ATWF01000002_gene309 1.11e-05 52.0 COG2199@1|root,COG3706@2|Bacteria 2|Bacteria T GGDEF domain - - 2.7.7.65 ko:K21088 ko02026,map02026 - - - ko00000,ko00001,ko01000 - - - GGDEF,dCache_2,dCache_3 k59_871133_1 395493.BegalDRAFT_1403 6.75e-22 101.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,463KB@72273|Thiotrichales 72273|Thiotrichales M PFAM Transglycosylase SLT domain - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_1243210_1 1161401.ASJA01000010_gene1420 7.03e-41 140.0 COG4244@1|root,COG4244@2|Bacteria,1RK8N@1224|Proteobacteria,2VG0D@28211|Alphaproteobacteria,4413H@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Predicted membrane protein (DUF2231) - - - - - - - - - - - - DUF2231,SnoaL_3 k59_1541751_1 1123368.AUIS01000021_gene1000 7.54e-07 49.7 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,2NCIZ@225057|Acidithiobacillales 225057|Acidithiobacillales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_1541751_2 314278.NB231_10828 2.75e-48 159.0 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1WY0Q@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N k59_1450487_1 261292.Nit79A3_3296 2.1e-133 402.0 COG1132@1|root,COG1132@2|Bacteria,1MYH7@1224|Proteobacteria,2VNDG@28216|Betaproteobacteria,373VF@32003|Nitrosomonadales 28216|Betaproteobacteria P ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_674553_1 1220535.IMCC14465_03730 1.69e-38 145.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2UTT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_1336528_1 1123392.AQWL01000002_gene1712 2.47e-13 70.9 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,1KSYA@119069|Hydrogenophilales 119069|Hydrogenophilales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1336528_2 768671.ThimaDRAFT_2361 8.84e-33 124.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales 135613|Chromatiales P PFAM TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_98149_1 575586.HMPREF0016_01453 2.53e-69 219.0 COG3239@1|root,COG3239@2|Bacteria,1N2FA@1224|Proteobacteria,1SC1D@1236|Gammaproteobacteria,3NIQR@468|Moraxellaceae 1236|Gammaproteobacteria I Fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_143992_1 331869.BAL199_29525 8.81e-05 44.3 COG2050@1|root,COG2050@2|Bacteria,1RGVD@1224|Proteobacteria,2U9MH@28211|Alphaproteobacteria,4BS8Z@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_143992_2 1096546.WYO_4182 2.32e-131 382.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,1JSX5@119045|Methylobacteriaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, middle domain ivd - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1450502_1 883067.HMPREF9237_00446 2.4e-36 141.0 COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,4D3B2@85005|Actinomycetales 201174|Actinobacteria KLT serine threonine protein kinase pknB GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_871168_1 765914.ThisiDRAFT_0003 5.81e-45 165.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1WXM6@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_831726_1 530564.Psta_3897 2.34e-94 300.0 COG2609@1|root,COG2609@2|Bacteria,2IXXY@203682|Planctomycetes 203682|Planctomycetes C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_186897_1 292415.Tbd_2662 3.72e-51 173.0 COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2VI6V@28216|Betaproteobacteria,1KRAF@119069|Hydrogenophilales 119069|Hydrogenophilales F ATP-grasp domain - - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_186897_2 1123393.KB891316_gene2032 2.45e-08 53.9 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2VQ1I@28216|Betaproteobacteria,1KRNW@119069|Hydrogenophilales 119069|Hydrogenophilales F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_871172_1 314285.KT71_17566 0.000159 43.5 COG0531@1|root,COG0531@2|Bacteria,1MUA2@1224|Proteobacteria,1RQ1P@1236|Gammaproteobacteria,1J76K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E amino acid - - - - - - - - - - - - AA_permease_2 k59_871172_2 1123279.ATUS01000001_gene2636 3.79e-10 58.5 COG1764@1|root,COG1764@2|Bacteria,1RJIP@1224|Proteobacteria,1S6QM@1236|Gammaproteobacteria,1J9ZC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O redox protein, regulator of disulfide bond formation - - - - - - - - - - - - OsmC k59_457130_1 335543.Sfum_1452 1.44e-49 171.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,2MRD6@213462|Syntrophobacterales 28221|Deltaproteobacteria L helicase superfamily c-terminal domain - - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_926529_1 1158292.JPOE01000002_gene3590 8.76e-52 177.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,1KJ21@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3 k59_1662439_1 472759.Nhal_0474 7e-34 121.0 COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,1SC8A@1236|Gammaproteobacteria,1WZJZ@135613|Chromatiales 135613|Chromatiales L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_831750_1 926550.CLDAP_04390 1.25e-38 141.0 COG0114@1|root,COG0114@2|Bacteria,2GBNI@200795|Chloroflexi 200795|Chloroflexi C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_831750_2 113395.AXAI01000005_gene3818 2.62e-08 55.1 COG0662@1|root,COG0662@2|Bacteria,1QW6S@1224|Proteobacteria 1224|Proteobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 k59_1601391_1 1121937.AUHJ01000001_gene775 1.48e-81 249.0 COG0300@1|root,COG0300@2|Bacteria,1MWNZ@1224|Proteobacteria,1RQTP@1236|Gammaproteobacteria,46CIC@72275|Alteromonadaceae 1236|Gammaproteobacteria S KR domain - - - ko:K07124 - - - - ko00000 - - - adh_short k59_1083082_1 1249627.D779_3472 2.62e-61 204.0 COG3359@1|root,COG3359@2|Bacteria,1R5KG@1224|Proteobacteria,1RY3P@1236|Gammaproteobacteria,1WXHZ@135613|Chromatiales 135613|Chromatiales L RNase_H superfamily - - - ko:K07502 - - - - ko00000 - - - RNase_H_2 k59_831753_1 588581.Cpap_3233 0.000374 46.2 COG2206@1|root,COG2206@2|Bacteria 2|Bacteria T PFAM metal-dependent phosphohydrolase, HD sub domain - - 3.6.1.11,3.6.1.40 ko:K01524,ko:K07012 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000,ko02048 - - - DEAD,GGDEF,HD,Helicase_C k59_1450520_1 742766.HMPREF9455_03718 1.17e-47 166.0 COG3547@1|root,COG3547@2|Bacteria,4NIKY@976|Bacteroidetes,2G38F@200643|Bacteroidia 976|Bacteroidetes L Transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_515732_1 1122137.AQXF01000003_gene2435 3.34e-39 147.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TTBG@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Chloride channel clcA - - ko:K03281 - - - - ko00000 2.A.49 - - Voltage_CLC k59_1083087_1 395493.BegalDRAFT_2979 8.81e-100 306.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,45ZSX@72273|Thiotrichales 72273|Thiotrichales NU Type II IV secretion system protein pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_716634_1 990285.RGCCGE502_07816 2.8e-13 68.6 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2TQZ0@28211|Alphaproteobacteria,4B9W4@82115|Rhizobiaceae 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_716634_2 648757.Rvan_3681 1.29e-58 192.0 COG1905@1|root,COG3743@1|root,COG1905@2|Bacteria,COG3743@2|Bacteria,1MWS2@1224|Proteobacteria,2TSEJ@28211|Alphaproteobacteria,3N6N8@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria C Thioredoxin-like [2Fe-2S] ferredoxin nuoE - 1.6.5.3,1.6.99.3 ko:K00334,ko:K03943 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 - - 2Fe-2S_thioredx k59_1509189_2 481448.Minf_1595 1.78e-10 62.0 COG2303@1|root,COG2303@2|Bacteria,46V33@74201|Verrucomicrobia,37H7W@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia E GMC oxidoreductase betA - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_1027568_1 436308.Nmar_0189 3.95e-37 142.0 COG0642@1|root,arCOG02358@2157|Archaea 2157|Archaea T Histidine kinase - - 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_515737_1 1430440.MGMSRv2_4147 8.63e-50 171.0 COG0572@1|root,COG0572@2|Bacteria,1MWCH@1224|Proteobacteria,2V6W9@28211|Alphaproteobacteria,2JRI2@204441|Rhodospirillales 204441|Rhodospirillales F Phosphoribulokinase / Uridine kinase family - - 2.7.1.19 ko:K00855 ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200 M00165,M00166 R01523 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PRK k59_186929_1 864051.BurJ1DRAFT_3787 3.14e-19 92.8 COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,2WHEI@28216|Betaproteobacteria,1KK66@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_144022_1 330214.NIDE3442 3.19e-37 140.0 COG3705@1|root,COG3705@2|Bacteria,3J13R@40117|Nitrospirae 40117|Nitrospirae E Histidyl-tRNA synthetase - - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_1450530_1 1131266.ARWQ01000002_gene480 1.62e-76 233.0 COG0558@1|root,arCOG00670@2157|Archaea,41SJ7@651137|Thaumarchaeota 651137|Thaumarchaeota I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.39 ko:K17884 - - R10464 RC00002,RC00078 ko00000,ko01000 - - - CDP-OH_P_transf k59_1450530_2 436308.Nmar_0925 1.45e-41 144.0 COG0010@1|root,arCOG01700@2157|Archaea,41T03@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the arginase family - - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_98199_1 439235.Dalk_4433 1.04e-46 155.0 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,42SCT@68525|delta/epsilon subdivisions,2WPA7@28221|Deltaproteobacteria,2MK72@213118|Desulfobacterales 28221|Deltaproteobacteria Q PFAM Mammalian cell entry related domain protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_557539_1 1297742.A176_07351 2.44e-72 237.0 COG0277@1|root,COG0277@2|Bacteria,1MXTV@1224|Proteobacteria,42RXR@68525|delta/epsilon subdivisions,2WNHV@28221|Deltaproteobacteria,2YYAR@29|Myxococcales 28221|Deltaproteobacteria C FAD linked oxidases, C-terminal domain - - 2.5.1.26 ko:K00803 ko00565,ko01100,ko04146,map00565,map01100,map04146 - R04311 RC00020,RC02886 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_17189_1 1049564.TevJSym_at00210 6.43e-59 201.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1J58Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1662490_1 1423734.JCM14202_2023 2.39e-06 55.1 COG0697@1|root,COG0697@2|Bacteria,1UHT1@1239|Firmicutes,4HCWY@91061|Bacilli,3F4PS@33958|Lactobacillaceae 91061|Bacilli EG EamA-like transporter family - - - - - - - - - - - - EamA k59_1027587_1 1131814.JAFO01000001_gene3831 4.77e-29 121.0 COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2TT9X@28211|Alphaproteobacteria,3EYMS@335928|Xanthobacteraceae 28211|Alphaproteobacteria EH Thiamine pyrophosphate enzyme, central domain oxc - 4.1.1.8 ko:K01577 ko00630,ko01100,map00630,map01100 - R01908 RC00620 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1135129_1 1469245.JFBG01000013_gene1937 2.08e-78 246.0 COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,1RN24@1236|Gammaproteobacteria 1236|Gammaproteobacteria S L-2-hydroxyglutarate oxidase LhgO - - - - - - - - - - - - DAO k59_515784_1 713586.KB900536_gene225 6.23e-13 69.7 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,1X0BZ@135613|Chromatiales 135613|Chromatiales S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1083122_1 589865.DaAHT2_2089 1.62e-35 133.0 COG0700@1|root,COG2715@1|root,COG0700@2|Bacteria,COG2715@2|Bacteria,1MVZ0@1224|Proteobacteria 1224|Proteobacteria S membrane protein required for spore maturation in B.subtilis spmB - - ko:K06374 - - - - ko00000 - - - Gate k59_1602081_2 592015.HMPREF1705_01260 4.73e-25 100.0 COG0727@1|root,COG0727@2|Bacteria,3TBB7@508458|Synergistetes 508458|Synergistetes S PFAM Uncharacterised protein family (UPF0153) - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_187963_1 35754.JNYJ01000039_gene10000 2.99e-09 63.5 COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4D8I6@85008|Micromonosporales 201174|Actinobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone - - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_1663937_1 378806.STAUR_1023 5.29e-16 79.7 COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria,438C4@68525|delta/epsilon subdivisions,2WYM4@28221|Deltaproteobacteria,2YWIJ@29|Myxococcales 28221|Deltaproteobacteria S hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_1 k59_676080_2 1184267.A11Q_2286 5.54e-13 67.0 2DMP9@1|root,32SV1@2|Bacteria,1N17Y@1224|Proteobacteria,42TQF@68525|delta/epsilon subdivisions,2MUCE@213481|Bdellovibrionales,2WQHJ@28221|Deltaproteobacteria 213481|Bdellovibrionales S Protein of unknown function (DUF3015) - - - - - - - - - - - - DUF3015 k59_259026_1 472759.Nhal_0908 3.5e-38 142.0 COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,1RZIZ@1236|Gammaproteobacteria,1WZ5E@135613|Chromatiales 135613|Chromatiales NU Type IV Pilus-assembly protein W - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_731081_1 1265505.ATUG01000002_gene1241 8.49e-47 163.0 COG0057@1|root,COG0057@2|Bacteria,1R8ZT@1224|Proteobacteria,42PY6@68525|delta/epsilon subdivisions,2WKEI@28221|Deltaproteobacteria,2MII4@213118|Desulfobacterales 28221|Deltaproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family - - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_1613056_1 1317118.ATO8_18175 5.88e-148 431.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG4584 Transposase and inactivated derivatives - - - - - - - - - - - - rve k59_779974_1 1265502.KB905969_gene1242 1e-34 134.0 COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,2VI8P@28216|Betaproteobacteria 28216|Betaproteobacteria EGP Major facilitator Superfamily ampG - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_1559847_1 1158150.KB906241_gene982 1.25e-57 181.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1WY86@135613|Chromatiales 135613|Chromatiales K Belongs to the P(II) protein family - - - ko:K04752 - - - - ko00000 - - - P-II k59_1559847_2 84531.JMTZ01000020_gene3692 7.31e-11 61.2 COG5331@1|root,COG5331@2|Bacteria,1N0MD@1224|Proteobacteria,1SF8F@1236|Gammaproteobacteria,1X7JH@135614|Xanthomonadales 135614|Xanthomonadales S MAPEG family - - - - - - - - - - - - MAPEG k59_731120_1 1122603.ATVI01000005_gene3040 5.64e-81 254.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1X4NW@135614|Xanthomonadales 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_1041618_1 268407.PWYN_12830 6.62e-17 85.5 COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,4HCJE@91061|Bacilli,26RRS@186822|Paenibacillaceae 91061|Bacilli GM GDP-mannose 4,6 dehydratase - - 5.1.3.2,5.1.3.25 ko:K01784,ko:K17947 ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130 M00361,M00362,M00632 R00291,R02984,R10279 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GAF_3,GDP_Man_Dehyd k59_1613081_1 521674.Plim_2047 6.01e-55 190.0 COG0443@1|root,COG0443@2|Bacteria,2IWWS@203682|Planctomycetes 203682|Planctomycetes O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_259093_1 287.DR97_2118 2.59e-15 80.1 COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,1RMUT@1236|Gammaproteobacteria,1YDQS@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth k59_731154_1 1259795.ARJK01000003_gene1197 7.29e-20 96.3 COG0673@1|root,COG0673@2|Bacteria,1TSWE@1239|Firmicutes,24DSM@186801|Clostridia,42EM5@68295|Thermoanaerobacterales 186801|Clostridia S Oxidoreductase domain protein - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_1408006_1 330214.NIDE3564 1.23e-10 69.3 COG4548@1|root,COG4548@2|Bacteria 2|Bacteria P von Willebrand factor (vWF) type A domain - - - ko:K02448 - - R00294 RC02794 ko00000 3.D.4.10 - - VWA,VWA_2 k59_259103_1 523791.Kkor_2096 2.24e-110 325.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,1XHJU@135619|Oceanospirillales 135619|Oceanospirillales P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_991116_2 1229909.NSED_02125 1.41e-86 266.0 COG0517@1|root,arCOG00601@2157|Archaea 2157|Archaea C CBS domain - - - - - - - - - - - - - k59_1196543_1 1194972.MVAC_15043 2.99e-23 104.0 COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria,2370G@1762|Mycobacteriaceae 201174|Actinobacteria S amidohydrolase nfdA_1 - - - - - - - - - - - Amidohydro_3 k59_991118_1 331869.BAL199_17668 3.17e-73 234.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2U0KX@28211|Alphaproteobacteria,4BT90@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria F COG0402 Cytosine deaminase and related metal-dependent hydrolases - - - - - - - - - - - - Amidohydro_1 k59_885294_1 1163617.SCD_n02099 5.82e-65 210.0 COG0530@1|root,COG0530@2|Bacteria,1PMXR@1224|Proteobacteria,2VNME@28216|Betaproteobacteria 28216|Betaproteobacteria P PFAM sodium calcium exchanger membrane region - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_1408018_1 1112217.PPL19_12243 2.68e-13 74.7 COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,1RMMI@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase pilS - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_1041658_1 1379270.AUXF01000005_gene551 9.3e-26 107.0 COG0412@1|root,COG0412@2|Bacteria,1ZUSZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Dienelactone hydrolase family - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_1196565_1 1278309.KB907099_gene2382 1.8e-06 48.5 COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,1SCXX@1236|Gammaproteobacteria,1XKZ0@135619|Oceanospirillales 135619|Oceanospirillales G Phosphocarrier protein HPr ptsO - - ko:K08485,ko:K11189 ko02060,map02060 - - - ko00000,ko00001,ko02000 4.A.2.1 - - PTS-HPr k59_1352762_1 472759.Nhal_0535 7.29e-106 310.0 COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,1RNF8@1236|Gammaproteobacteria,1WVVE@135613|Chromatiales 135613|Chromatiales G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A k59_1196584_1 479435.Kfla_2118 0.000178 44.3 COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,2GMMC@201174|Actinobacteria,4DPP6@85009|Propionibacteriales 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - 1.17.1.9,1.6.5.3 ko:K00122,ko:K00335 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_1196584_2 1192034.CAP_2430 1.47e-25 102.0 COG0746@1|root,COG0746@2|Bacteria,1RKCH@1224|Proteobacteria,42T8X@68525|delta/epsilon subdivisions,2X9X1@28221|Deltaproteobacteria,2YW7C@29|Myxococcales 28221|Deltaproteobacteria H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA - 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_731213_1 485913.Krac_3213 4.27e-134 399.0 COG0477@1|root,COG0477@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1560019_1 472759.Nhal_3648 2.63e-25 109.0 COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1WVZW@135613|Chromatiales 135613|Chromatiales NU Type II and III secretion system protein - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_885336_1 565045.NOR51B_273 2.02e-22 98.2 COG0494@1|root,COG0494@2|Bacteria,1QXXS@1224|Proteobacteria,1T3JK@1236|Gammaproteobacteria 1236|Gammaproteobacteria L LR COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - - - - - - - - - - NUDIX k59_731234_1 944479.JQLX01000013_gene1442 2.75e-52 178.0 COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2X71A@28221|Deltaproteobacteria 28221|Deltaproteobacteria T metal-dependent phosphohydrolase HD region - - - - - - - - - - - - GAF,GAF_2,GAF_3,HAMP,HD,HD_5 k59_780103_1 102129.Lepto7375DRAFT_1889 6.94e-33 119.0 COG0640@1|root,COG0640@2|Bacteria,1G8MQ@1117|Cyanobacteria 1117|Cyanobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_20 k59_780103_2 258594.RPA3562 7.83e-59 191.0 COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2TR8A@28211|Alphaproteobacteria,3K275@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H Hypothetical methyltransferase - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_11,Methyltransf_31 k59_259198_1 497964.CfE428DRAFT_4961 4.65e-09 62.8 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,46UMD@74201|Verrucomicrobia 2|Bacteria O Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_991294_1 436308.Nmar_1466 4.05e-89 268.0 COG0367@1|root,arCOG00071@2157|Archaea,41SIX@651137|Thaumarchaeota 651137|Thaumarchaeota E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase k59_991310_1 745310.G432_04840 2.07e-84 256.0 COG1028@1|root,COG1028@2|Bacteria,1PGYV@1224|Proteobacteria,2VEVG@28211|Alphaproteobacteria,2K2ZW@204457|Sphingomonadales 204457|Sphingomonadales IQ short-chain dehydrogenase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_991318_1 944547.ABLL_2318 1.47e-17 88.2 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43BUW@68525|delta/epsilon subdivisions,2YRCI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - GGDEF k59_991318_2 756272.Plabr_2236 1.29e-13 71.6 COG0392@1|root,COG0392@2|Bacteria,2J055@203682|Planctomycetes 203682|Planctomycetes S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_572278_1 1120977.JHUX01000010_gene129 3.29e-07 55.8 COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,1SWVA@1236|Gammaproteobacteria,3NIVY@468|Moraxellaceae 1236|Gammaproteobacteria S Uncharacterized ACR, COG1399 - - - ko:K07040 - - - - ko00000 - - - DUF177 k59_1565253_2 1522072.IL54_1367 7.71e-13 65.5 2DVDD@1|root,32UZ7@2|Bacteria,1NGRW@1224|Proteobacteria,2UC61@28211|Alphaproteobacteria,2K7IU@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF2933) - - - - - - - - - - - - DUF2933 k59_783340_1 269798.CHU_0916 1.36e-95 293.0 COG0004@1|root,COG0004@2|Bacteria,4NDV2@976|Bacteroidetes,47N2A@768503|Cytophagia 976|Bacteroidetes P Ammonium Transporter Family - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_1200047_1 478741.JAFS01000001_gene1958 2.52e-68 221.0 COG0423@1|root,COG0423@2|Bacteria,46TEV@74201|Verrucomicrobia,37GG5@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia J Catalyzes the attachment of glycine to tRNA(Gly) glyQS - 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b k59_1356004_1 323261.Noc_0800 2.45e-16 76.6 COG3298@1|root,COG3298@2|Bacteria,1MVZJ@1224|Proteobacteria,1S4HU@1236|Gammaproteobacteria,1X0C4@135613|Chromatiales 135613|Chromatiales L 3'-5' exonuclease - - - ko:K07501 - - - - ko00000 - - - DNA_pol_B_exo2 k59_1356004_2 1380387.JADM01000007_gene656 1e-69 220.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1XHJW@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the cysteine synthase cystathionine beta- synthase family cysM - 2.5.1.47 ko:K12339 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03132,R03601,R04859 RC00020,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1565285_2 1434929.X946_1903 8.29e-18 80.9 COG0346@1|root,COG0346@2|Bacteria,1N7R0@1224|Proteobacteria,2VV7K@28216|Betaproteobacteria,1KHF4@119060|Burkholderiaceae 28216|Betaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_1615570_1 1163617.SCD_n02943 2.63e-05 47.4 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,2VH68@28216|Betaproteobacteria 28216|Betaproteobacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_1615570_2 1122604.JONR01000010_gene3937 7.8e-39 138.0 COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,1S6VJ@1236|Gammaproteobacteria,1X61Y@135614|Xanthomonadales 135614|Xanthomonadales NU pilus assembly protein pilp pilP - - ko:K02665 - - - - ko00000,ko02035,ko02044 - - - PilP k59_1200105_1 1150864.MILUP08_44438 3.93e-51 171.0 COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4D9ND@85008|Micromonosporales 201174|Actinobacteria V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1356080_1 1379270.AUXF01000005_gene406 3.75e-31 124.0 COG1232@1|root,COG1232@2|Bacteria,1ZUZT@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX - - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_1200145_1 1110502.TMO_2053 6.71e-72 240.0 COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,2TRSY@28211|Alphaproteobacteria,2JPPS@204441|Rhodospirillales 204441|Rhodospirillales V ABC transporter transmembrane region - - - ko:K02021 - - - - ko00000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran,cNMP_binding k59_1356116_1 1049564.TevJSym_at00260 1.05e-62 208.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1J4GC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - iECSE_1348.ECSE_3895,iJN746.PP_5056 Metalloenzyme,Phosphodiest,iPGM_N k59_1565514_2 519989.ECTPHS_10129 6.84e-21 94.0 COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,1S9FW@1236|Gammaproteobacteria,1WXHE@135613|Chromatiales 135613|Chromatiales M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA - - ko:K03634 - - - - ko00000 - - - LolA k59_1615718_1 448385.sce6319 2.42e-171 490.0 COG3344@1|root,COG3344@2|Bacteria,1REEG@1224|Proteobacteria,43BHY@68525|delta/epsilon subdivisions,2X6WC@28221|Deltaproteobacteria,2Z3DB@29|Myxococcales 1224|Proteobacteria L High confidence in function and specificity - - - - - - - - - - - - RVT_1 k59_1615732_1 1123368.AUIS01000004_gene237 6.29e-70 213.0 COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,1RNXM@1236|Gammaproteobacteria,2NCX7@225057|Acidithiobacillales 225057|Acidithiobacillales F Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF k59_25451_1 1131553.JIBI01000039_gene1952 8.5e-74 236.0 COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,2VKNE@28216|Betaproteobacteria,372VG@32003|Nitrosomonadales 28216|Betaproteobacteria S Vacuole effluxer Atg22 like - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_1200379_1 268746.Q58MX1_BPPRM 4.07e-76 256.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_1200389_2 436308.Nmar_1605 1.23e-68 217.0 COG2262@1|root,arCOG00353@2157|Archaea,41SD4@651137|Thaumarchaeota 651137|Thaumarchaeota S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_25485_1 439235.Dalk_0613 9.44e-30 124.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,43BJ8@68525|delta/epsilon subdivisions,2X708@28221|Deltaproteobacteria,2MJ7A@213118|Desulfobacterales 28221|Deltaproteobacteria M Transglycosylase - - 2.4.1.129,3.4.16.4 ko:K05366,ko:K21464 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_1565822_1 161156.JQKW01000006_gene1306 7e-111 332.0 COG0162@1|root,COG0162@2|Bacteria,2GGUK@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_1200462_1 596154.Alide2_0319 5.7e-63 207.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,4ABEH@80864|Comamonadaceae 28216|Betaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1615847_1 1038859.AXAU01000003_gene6195 1.59e-96 307.0 COG3203@1|root,COG3203@2|Bacteria,1R49B@1224|Proteobacteria 1224|Proteobacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - DUF3573 k59_1565953_1 1501230.ET33_05660 6.76e-08 51.2 2AEQG@1|root,314M1@2|Bacteria,1VQFC@1239|Firmicutes,4HRE0@91061|Bacilli,270IH@186822|Paenibacillaceae 91061|Bacilli S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 k59_1565988_1 1121271.AUCM01000007_gene3696 3.1e-15 81.3 COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2U2B6@28211|Alphaproteobacteria 28211|Alphaproteobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_1615882_1 1026882.MAMP_01551 4.32e-27 111.0 COG1295@1|root,COG1959@1|root,COG1295@2|Bacteria,COG1959@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,45ZQW@72273|Thiotrichales 72273|Thiotrichales K TIGRFAM YihY family protein (not ribonuclease BN) - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_25557_1 1229909.NSED_02980 8.82e-70 213.0 arCOG10529@1|root,arCOG10529@2157|Archaea,41T4K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_75449_1 997346.HMPREF9374_2726 7.24e-24 100.0 COG0584@1|root,COG0584@2|Bacteria,1UWKN@1239|Firmicutes,4I2FI@91061|Bacilli,27CYQ@186824|Thermoactinomycetaceae 91061|Bacilli C Glycerophosphoryl diester phosphodiesterase family - - - - - - - - - - - - GDPD k59_75449_2 1215114.BBIU01000039_gene3848 5.22e-19 87.4 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,1RMAF@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019405,GO:0019563,GO:0019751,GO:0033554,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:1901575,GO:1901615,GO:1901616 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - iE2348C_1286.E2348C_4230,iECNA114_1301.ECNA114_4065,iECSF_1327.ECSF_3786 FGGY_C,FGGY_N k59_1375931_1 323261.Noc_2636 4.82e-146 425.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_332101_2 857087.Metme_3485 3.25e-11 59.7 COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria,1XF9T@135618|Methylococcales 135618|Methylococcales NU PFAM Type IV pilus assembly PilZ pilZ - - ko:K02676 - - - - ko00000,ko02035,ko02044 - - - PilZ k59_1277063_1 1347342.BN863_12390 0.000865 47.8 COG2905@1|root,COG2905@2|Bacteria,4NDZ8@976|Bacteroidetes,1HWQU@117743|Flavobacteriia 976|Bacteroidetes T signal-transduction protein containing cAMP-binding and CBS - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_698990_1 330214.NIDE2516 6.55e-158 453.0 COG0006@1|root,COG0006@2|Bacteria,3J0R0@40117|Nitrospirae 40117|Nitrospirae E Metallopeptidase family M24 - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_592525_1 1095769.CAHF01000021_gene941 2.09e-79 249.0 COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria 1224|Proteobacteria G Extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 k59_539972_1 713587.THITH_02640 1.16e-81 256.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales 135613|Chromatiales C Cysteine-rich domain - - - - - - - - - - - - CCG k59_491206_1 404589.Anae109_1137 1.01e-60 197.0 COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,42R2J@68525|delta/epsilon subdivisions,2WIJ6@28221|Deltaproteobacteria,2YV01@29|Myxococcales 28221|Deltaproteobacteria J FtsJ-like methyltransferase tlyA - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k59_650109_1 1273125.Rrhod_1014 5.92e-21 95.9 COG2937@1|root,COG2937@2|Bacteria,2GMQF@201174|Actinobacteria,4FWRE@85025|Nocardiaceae 201174|Actinobacteria I Belongs to the GPAT DAPAT family plsB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_650109_2 1380356.JNIK01000003_gene1260 5.73e-07 52.0 COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,4EU00@85013|Frankiales 201174|Actinobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_698994_1 290398.Csal_1220 7.71e-17 80.1 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1XHT9@135619|Oceanospirillales 135619|Oceanospirillales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_698994_2 906968.Trebr_2028 1.8e-40 147.0 COG1053@1|root,COG1053@2|Bacteria,2J6FD@203691|Spirochaetes 203691|Spirochaetes C PFAM fumarate reductase succinate dehydrogenase flavoprotein - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_75465_1 199306.XP_003068696.1 1.46e-17 88.2 COG1804@1|root,KOG3957@2759|Eukaryota,38CWZ@33154|Opisthokonta,3NU4P@4751|Fungi,3QPIY@4890|Ascomycota,20BUM@147545|Eurotiomycetes,3AZ4P@33183|Onygenales,3FKCI@34383|Onygenales incertae sedis 4751|Fungi C CoA-transferase family III - - 2.8.3.13 ko:K18703 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_807220_1 1206720.BAFQ01000052_gene1292 2.04e-06 49.7 COG1225@1|root,COG1225@2|Bacteria,2IHZ6@201174|Actinobacteria,4FVR7@85025|Nocardiaceae 201174|Actinobacteria O Redoxin bcp GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_807220_2 398767.Glov_2275 1.32e-34 128.0 COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,42Q7J@68525|delta/epsilon subdivisions,2WJCK@28221|Deltaproteobacteria,43T44@69541|Desulfuromonadales 28221|Deltaproteobacteria O PFAM cytochrome c biogenesis protein, transmembrane region ccdA - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD,Thioredoxin k59_1222543_1 795359.TOPB45_0337 4.74e-25 103.0 COG4122@1|root,COG4122@2|Bacteria 2|Bacteria E O-methyltransferase activity - - - ko:K05303 - - - - ko00000,ko01000 - - - Methyltransf_24,TPR_11,TylF k59_75472_1 1348657.M622_13655 1.31e-69 221.0 COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,2VJ1V@28216|Betaproteobacteria,2KVJ5@206389|Rhodocyclales 206389|Rhodocyclales C 4Fe-4S dicluster domain - - - ko:K17048,ko:K17051 ko00642,ko01100,ko01120,ko01220,map00642,map01100,map01120,map01220 - R05745 RC00275 ko00000,ko00001,ko02000 5.A.3.8,5.A.3.9 - - Fer4_11 k59_1010229_1 1142394.PSMK_09270 1.92e-05 47.4 COG2423@1|root,COG2423@2|Bacteria,2IXT1@203682|Planctomycetes 203682|Planctomycetes E ornithine cyclodeaminase mu-crystallin - - 4.3.1.12 ko:K01750 ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230 - R00671 RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall k59_1222554_1 330214.NIDE0762 4.63e-116 344.0 COG0773@1|root,COG0773@2|Bacteria,3J0D5@40117|Nitrospirae 40117|Nitrospirae M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_491224_1 1007105.PT7_0628 4.4e-41 145.0 COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,2VIQI@28216|Betaproteobacteria,3T3I8@506|Alcaligenaceae 28216|Betaproteobacteria K Cyclic nucleotide-monophosphate binding domain dnrD - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1527071_1 575788.VS_0354 3.95e-290 818.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria,1XUHS@135623|Vibrionales 135623|Vibrionales S transport system, fused permease components - - - - - - - - - - - - DUF3394,DctM k59_76607_1 740709.A10D4_05307 1.66e-26 100.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,2QG3R@267893|Idiomarinaceae 1236|Gammaproteobacteria J endoribonuclease tdcF - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_1223645_1 1122197.ATWI01000009_gene2018 1.32e-40 149.0 COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria,464YM@72275|Alteromonadaceae 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494 1.6.5.8 ko:K00346 - - - - ko00000,ko01000 - - - NQRA,NQRA_SLBB k59_593424_1 1385515.N791_12140 4.4e-25 109.0 COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,1RQAI@1236|Gammaproteobacteria,1X4WG@135614|Xanthomonadales 135614|Xanthomonadales H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - - k59_907252_1 269482.Bcep1808_6103 1.36e-09 58.9 COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2VKAX@28216|Betaproteobacteria,1K3UW@119060|Burkholderiaceae 28216|Betaproteobacteria S Chromate resistance chrB - - - - - - - - - - - Chrome_Resist k59_332994_2 349521.HCH_03720 4.96e-06 53.1 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1XI0Q@135619|Oceanospirillales 135619|Oceanospirillales P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE k59_76612_1 292415.Tbd_0991 4.63e-41 147.0 COG0596@1|root,COG0596@2|Bacteria,1RJQK@1224|Proteobacteria,2W4YC@28216|Betaproteobacteria 28216|Betaproteobacteria S Alpha beta hydrolase - - - - - - - - - - - - - k59_1376753_1 666685.R2APBS1_3947 5.5e-51 181.0 COG1257@1|root,COG1577@1|root,COG1257@2|Bacteria,COG1577@2|Bacteria,1MXVE@1224|Proteobacteria,1RS9R@1236|Gammaproteobacteria,1X8RF@135614|Xanthomonadales 135614|Xanthomonadales I Hydroxymethylglutaryl-coenzyme A reductase - - 1.1.1.88 ko:K00054 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R02081 RC00004,RC00644 ko00000,ko00001,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N,HMG-CoA_red k59_1585691_1 765913.ThidrDRAFT_0469 3.33e-127 389.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1X08T@135613|Chromatiales 135613|Chromatiales M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_1064162_1 309800.C498_09586 2.14e-55 195.0 COG0531@1|root,COG0589@1|root,arCOG00009@2157|Archaea,arCOG00449@2157|Archaea,2XTX6@28890|Euryarchaeota,23SWT@183963|Halobacteria 183963|Halobacteria E COG0531 Amino acid transporters - - - - - - - - - - - - AA_permease,AA_permease_2,Usp k59_699897_1 1267534.KB906755_gene3923 1.2e-20 90.1 COG2107@1|root,COG2107@2|Bacteria,3Y31U@57723|Acidobacteria,2JIDE@204432|Acidobacteriia 204432|Acidobacteriia S Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnD - - ko:K11785 ko00130,ko01110,map00130,map01110 - R08589 RC02330 ko00000,ko00001,ko01000 - - - VitK2_biosynth k59_333000_1 1123257.AUFV01000007_gene277 5.55e-85 263.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,1X3XW@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_1322166_1 1112274.KI911560_gene1213 6.32e-106 317.0 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,2VIXE@28216|Betaproteobacteria,2KM5N@206350|Nitrosomonadales 206350|Nitrosomonadales F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,Formyl_trans_N k59_907261_1 536227.CcarbDRAFT_4636 1.35e-17 89.4 COG0627@1|root,COG0627@2|Bacteria,1VT84@1239|Firmicutes,24FKY@186801|Clostridia,36G2F@31979|Clostridiaceae 186801|Clostridia S PFAM Tannase and feruloyl esterase - - 3.1.1.102 ko:K21105 - - R11541 RC00020,RC00041 ko00000,ko01000 - - - Tannase k59_1011119_1 1198232.CYCME_0772 1.15e-46 151.0 COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,1S5ZK@1236|Gammaproteobacteria,460Y4@72273|Thiotrichales 72273|Thiotrichales C Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions fdxA - - ko:K05524 - - - - ko00000 - - - DUF3470,Fer4 k59_333006_1 288000.BBta_7051 1.19e-56 192.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,3JRI2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily yejF GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K02031,ko:K02032,ko:K13896 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - ABC_tran,oligo_HPY k59_387154_1 706587.Desti_1387 6.16e-06 53.9 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,42M9D@68525|delta/epsilon subdivisions,2WJ43@28221|Deltaproteobacteria 68525|delta/epsilon subdivisions C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_280551_1 472759.Nhal_1513 5.71e-75 232.0 COG1132@1|root,COG1132@2|Bacteria,1MX5V@1224|Proteobacteria,1RY02@1236|Gammaproteobacteria,1WXG2@135613|Chromatiales 135613|Chromatiales V (ABC) transporter - - - - - - - - - - - - - k59_280551_2 323261.Noc_2703 3.08e-43 150.0 COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,1RM7T@1236|Gammaproteobacteria,1WWUS@135613|Chromatiales 135613|Chromatiales E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metAS - 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - HTS k59_1223670_1 396588.Tgr7_0352 9.43e-64 205.0 2BX2I@1|root,2Z9KR@2|Bacteria,1MXKC@1224|Proteobacteria,1RRV2@1236|Gammaproteobacteria,1WXVA@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_1223670_2 713587.THITH_01410 1.1e-19 82.4 COG1146@1|root,COG1146@2|Bacteria,1R4GP@1224|Proteobacteria,1RXXW@1236|Gammaproteobacteria,1WVWW@135613|Chromatiales 135613|Chromatiales C reductase beta subunit - - 1.8.99.2 ko:K00395 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - APS-reductase_C,Fer4,Fer4_9 k59_1638941_1 1265313.HRUBRA_00591 8.92e-42 146.0 COG0826@1|root,COG0826@2|Bacteria,1MWFW@1224|Proteobacteria,1RMWM@1236|Gammaproteobacteria,1J5V7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Peptidase family U32 yhbV - - - - - - - - - - - Peptidase_U32 k59_1638941_2 267608.RSp0970 1.67e-29 114.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VH51@28216|Betaproteobacteria,1K6HP@119060|Burkholderiaceae 28216|Betaproteobacteria O peptidase, U32 yhbU - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32,Peptidase_U32_C k59_808416_1 981223.AIED01000009_gene3234 8.72e-54 191.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,3NJFY@468|Moraxellaceae 1236|Gammaproteobacteria M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) mrcB GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008289,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042277,GO:0042546,GO:0042597,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071723,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iECIAI39_1322.ECIAI39_0153,iSBO_1134.SBO_0138,iSbBS512_1146.SbBS512_E0140,iYL1228.KPN_00164 PBP1_TM,Transgly,Transpeptidase,UB2H k59_1432326_1 314278.NB231_16458 7.06e-195 595.0 COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1WWBR@135613|Chromatiales 135613|Chromatiales G PFAM glycoside hydrolase, family 77 - - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_699921_1 485913.Krac_7993 9.3e-20 92.8 COG0143@1|root,COG0143@2|Bacteria 2|Bacteria J methionyl-tRNA aminoacylation metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1g k59_699921_2 1307761.L21SP2_0430 4.78e-05 45.1 COG0722@1|root,COG0722@2|Bacteria,2J6I9@203691|Spirochaetes 203691|Spirochaetes E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) - - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_227800_1 713586.KB900536_gene665 6.51e-102 308.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1WWK3@135613|Chromatiales 135613|Chromatiales S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_593458_1 439235.Dalk_3918 2.32e-70 240.0 COG0784@1|root,COG2198@1|root,COG2202@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BU6@68525|delta/epsilon subdivisions,2X756@28221|Deltaproteobacteria,2MPM5@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,MASE1,PAS_9,Response_reg k59_172895_1 1232410.KI421413_gene607 1.15e-38 138.0 COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,42PJV@68525|delta/epsilon subdivisions,2WKRG@28221|Deltaproteobacteria,43TN5@69541|Desulfuromonadales 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel k59_76651_1 686340.Metal_2996 1.43e-91 279.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1XEPY@135618|Methylococcales 135618|Methylococcales H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_1064185_1 765911.Thivi_1112 6.48e-139 412.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1WWGN@135613|Chromatiales 135613|Chromatiales F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_1064185_2 1002339.HMPREF9373_1883 2.21e-18 80.1 COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,1SD35@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters fis GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K03557 ko05111,map05111 - - - ko00000,ko00001,ko03000,ko03036,ko03400 - - - HTH_8 k59_1064185_3 1123368.AUIS01000015_gene2660 3.19e-48 164.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB GO:0002943,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_808424_1 1035191.HMPREF0185_00665 2.69e-26 104.0 COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2UBUR@28211|Alphaproteobacteria,2KHGB@204458|Caulobacterales 204458|Caulobacterales S Copper chaperone PCu(A)C - - - ko:K09796 - - - - ko00000,ko03110 - - - PCuAC k59_854919_2 59538.XP_005974403.1 2.02e-42 154.0 COG0318@1|root,KOG1176@2759|Eukaryota,3AIZB@33154|Opisthokonta,3BXNQ@33208|Metazoa,3DFMP@33213|Bilateria,48SPA@7711|Chordata,49P71@7742|Vertebrata,3JP3T@40674|Mammalia,4J1NF@91561|Cetartiodactyla 33208|Metazoa I 4-coumarate--CoA - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_76657_1 637390.AFOH01000117_gene2741 2.34e-76 242.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,2NC14@225057|Acidithiobacillales 225057|Acidithiobacillales E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_1116110_1 247490.KSU1_D0514 1.15e-13 70.9 COG3055@1|root,COG3204@1|root,COG3055@2|Bacteria,COG3204@2|Bacteria 2|Bacteria L pilus organization - - - ko:K02674,ko:K07004 - - - - ko00000,ko02035,ko02044 - - - Big_5,Exo_endo_phos,He_PIG,HemolysinCabind,LTD,Laminin_G_3,Malectin,PA14 k59_1432343_1 631454.N177_3894 0.000194 44.3 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,1JP3A@119043|Rhodobiaceae 28211|Alphaproteobacteria CP Proton-conducting membrane transporter nuoN2 - 1.6.5.3 ko:K00343,ko:K05568 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 - - Proton_antipo_M k59_1432343_2 1198232.CYCME_1783 1.12e-53 171.0 COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria,1S6BB@1236|Gammaproteobacteria,462SY@72273|Thiotrichales 72273|Thiotrichales P NADH-ubiquinone/plastoquinone oxidoreductase chain 4L - - - ko:K05567 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Oxidored_q2 k59_1376792_1 1265310.CCBD010000089_gene4462 8.04e-67 223.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,233NX@1762|Mycobacteriaceae 201174|Actinobacteria C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 k59_1278292_1 1049564.TevJSym_ad00120 5.91e-30 120.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1J4MP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind k59_1278292_2 686340.Metal_0701 9.93e-53 167.0 COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,1S61Z@1236|Gammaproteobacteria,1XFE0@135618|Methylococcales 135618|Methylococcales K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control himA - - ko:K04764 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_437701_1 298655.KI912266_gene6038 2.09e-28 115.0 COG3653@1|root,COG3653@2|Bacteria,2IE6H@201174|Actinobacteria 201174|Actinobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_437704_1 1125863.JAFN01000001_gene3383 1.63e-82 256.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2WIQN@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_1064200_1 330214.NIDE3283 1.93e-86 269.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1327642_2 1384054.N790_05510 1.04e-12 69.3 COG0823@1|root,COG0823@2|Bacteria,1MWYK@1224|Proteobacteria,1RXYW@1236|Gammaproteobacteria,1XD03@135614|Xanthomonadales 135614|Xanthomonadales U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 k59_1648560_1 1121035.AUCH01000015_gene2502 8.19e-44 162.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,2KVW3@206389|Rhodocyclales 206389|Rhodocyclales T CHASE2 - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_706591_1 321332.CYB_0078 5.87e-64 203.0 COG1187@1|root,COG1187@2|Bacteria,1G56K@1117|Cyanobacteria,1GZBQ@1129|Synechococcus 1117|Cyanobacteria J Belongs to the pseudouridine synthase RsuA family - GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.20 ko:K06181 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_1171276_1 246437.XP_006167263.1 1.43e-107 331.0 COG1249@1|root,KOG0405@2759|Eukaryota,39J8D@33154|Opisthokonta,3BDB0@33208|Metazoa,3D06N@33213|Bilateria,482J2@7711|Chordata,48UWV@7742|Vertebrata,3J217@40674|Mammalia,359E9@314146|Euarchontoglires 33208|Metazoa C glutathione-disulfide reductase activity GSR GO:0000003,GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0002931,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0006091,GO:0006139,GO:0006518,GO:0006575,GO:0006725,GO:0006749,GO:0006790,GO:0006807,GO:0006950,GO:0006979,GO:0007276,GO:0007283,GO:0007568,GO:0007584,GO:0008150,GO:0008152,GO:0009055,GO:0009605,GO:0009636,GO:0009897,GO:0009986,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0014823,GO:0015036,GO:0015037,GO:0015038,GO:0015949,GO:0016020,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018996,GO:0019953,GO:0022404,GO:0022414,GO:0022900,GO:0031667,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0033189,GO:0033218,GO:0033273,GO:0033554,GO:0033993,GO:0034599,GO:0034641,GO:0035094,GO:0036094,GO:0042221,GO:0042277,GO:0042303,GO:0042395,GO:0042493,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043295,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044703,GO:0045471,GO:0046483,GO:0046677,GO:0046686,GO:0046983,GO:0048037,GO:0048232,GO:0048609,GO:0050660,GO:0050661,GO:0050662,GO:0050896,GO:0051186,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0070013,GO:0070887,GO:0071704,GO:0071944,GO:0072341,GO:0097159,GO:0097237,GO:0097305,GO:0098552,GO:0098622,GO:0098754,GO:0098869,GO:1900750,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901681,GO:1901700,GO:1990748 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_600458_1 1224136.AMFN01000003_gene3167 3.49e-22 92.8 COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,283CK@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria E Histidine biosynthesis bifunctional protein HisIE hisI GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31 ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186 PRA-CH,PRA-PH k59_600458_2 1328313.DS2_11638 5.4e-11 62.4 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,1RPJQ@1236|Gammaproteobacteria,464M7@72275|Alteromonadaceae 1236|Gammaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 - ko:K01663,ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_2749,iEcolC_1368.EcolC_1617,iYL1228.KPN_02481 His_biosynth k59_339864_2 472759.Nhal_0347 3.14e-34 125.0 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,1RNJW@1236|Gammaproteobacteria,1WXHN@135613|Chromatiales 135613|Chromatiales Q PFAM toluene tolerance - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_817910_1 237368.SCABRO_02251 2.09e-07 52.8 COG1218@1|root,COG1218@2|Bacteria 2|Bacteria P 3'(2'),5'-bisphosphate nucleotidase activity cysQ - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_817910_2 1384054.N790_13455 2.16e-25 100.0 COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,1S3ZE@1236|Gammaproteobacteria,1X3RK@135614|Xanthomonadales 135614|Xanthomonadales L ADP-ribose diphosphatase nudE - - ko:K08312 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_12033_4 1231190.NA8A_00035 8.3e-10 60.1 COG3926@1|root,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,2TT3H@28211|Alphaproteobacteria,43JWV@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S secretion activating protein - - - - - - - - - - - - Glyco_hydro_108,PG_binding_3 k59_1592720_1 1238190.AMQY01000001_gene679 1.82e-37 143.0 COG4467@1|root,COG4467@2|Bacteria,1QYSW@1224|Proteobacteria,1T3T6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Transposase IS66 family - - - - - - - - - - - - - k59_706606_1 395961.Cyan7425_1210 2.59e-15 77.4 COG1612@1|root,COG1612@2|Bacteria,1G08Q@1117|Cyanobacteria,3KGX2@43988|Cyanothece 1117|Cyanobacteria O cytochrome oxidase assembly ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_965343_1 76114.ebA3949 9.74e-25 102.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2VICZ@28216|Betaproteobacteria,2KVIC@206389|Rhodocyclales 206389|Rhodocyclales M Lipid A biosynthesis acyltransferase - - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_965343_2 382245.ASA_2195 1.5e-45 162.0 COG1560@1|root,COG1560@2|Bacteria,1N9ZJ@1224|Proteobacteria,1RRI7@1236|Gammaproteobacteria,1Y44Y@135624|Aeromonadales 135624|Aeromonadales M Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A lpxM - 2.3.1.243 ko:K02560 ko00540,ko01100,map00540,map01100 M00060 R05075 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_1123043_1 722419.PH505_bp00060 3.42e-13 68.9 COG2197@1|root,COG2197@2|Bacteria,1N8MU@1224|Proteobacteria,1S90D@1236|Gammaproteobacteria,2Q4VI@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_445718_1 330214.NIDE4127 1.93e-74 243.0 COG1185@1|root,COG1185@2|Bacteria,3J0DX@40117|Nitrospirae 40117|Nitrospirae J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_339890_1 1121403.AUCV01000020_gene3113 2.56e-05 45.1 COG0824@1|root,COG0824@2|Bacteria,1PEBE@1224|Proteobacteria,42TIA@68525|delta/epsilon subdivisions,2WQ9X@28221|Deltaproteobacteria,2MMDF@213118|Desulfobacterales 28221|Deltaproteobacteria S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_339890_2 485916.Dtox_1375 5.37e-19 89.0 COG3635@1|root,COG3635@2|Bacteria,1TQ5S@1239|Firmicutes,248U6@186801|Clostridia,260J7@186807|Peptococcaceae 186801|Clostridia G proposed homoserine kinase - - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase k59_234527_1 1137745.H6WFV8_9CAUD 1.05e-23 104.0 4QKHU@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1287877_2 1121468.AUBR01000039_gene1946 6.51e-48 174.0 COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,42F45@68295|Thermoanaerobacterales 186801|Clostridia S conserved protein UCP033563 - - - - - - - - - - - - DUF1015 k59_234528_1 436308.Nmar_1390 8.73e-91 273.0 COG0167@1|root,arCOG00603@2157|Archaea 2157|Archaea F Catalyzes the conversion of dihydroorotate to orotate pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.1,1.3.1.14,1.3.5.2,1.3.98.1 ko:K00226,ko:K00254,ko:K17723,ko:K17828 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046,M00051 R00977,R01414,R01867,R01868,R01869,R11026 RC00051,RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_1171318_1 1121004.ATVC01000027_gene153 2.75e-21 91.3 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,2VIQ5@28216|Betaproteobacteria,2KPVN@206351|Neisseriales 206351|Neisseriales H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_1171318_2 330214.NIDE0998 4.7e-87 258.0 COG0440@1|root,COG0440@2|Bacteria,3J0K8@40117|Nitrospirae 40117|Nitrospirae E ACT domain - - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_706623_1 41431.PCC8801_4270 1.75e-49 172.0 COG4671@1|root,COG4671@2|Bacteria,1G0X1@1117|Cyanobacteria,3KGIG@43988|Cyanothece 1117|Cyanobacteria S Glycosyl transferase family 1 - - - - - - - - - - - iJN678.sll1722 Glyco_tran_28_C k59_1327697_1 1123034.JMKP01000006_gene900 6.56e-08 53.1 COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,3NMPJ@468|Moraxellaceae 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrD GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015672,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030001,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0051179,GO:0051234,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.6.5.8 ko:K00349 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_1327697_2 595494.Tola_2995 1.52e-27 109.0 COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,1RR85@1236|Gammaproteobacteria,1Y44N@135624|Aeromonadales 135624|Aeromonadales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrC - 1.6.5.8 ko:K00348 - - - - ko00000,ko01000 - - - FMN_bind k59_1071138_1 330214.NIDE0232 8.62e-28 113.0 COG3383@1|root,COG3383@2|Bacteria,3J0UR@40117|Nitrospirae 2|Bacteria C Molydopterin dinucleotide binding domain hcnA - 1.4.99.5,1.5.3.1 ko:K00302,ko:K10814 ko00260,ko00460,ko01100,ko01110,map00260,map00460,map01100,map01110 - R00374,R00610,R05704 RC00060,RC00557,RC02808 ko00000,ko00001,ko01000,ko02042 - - - Fer2_4 k59_600493_1 330214.NIDE3313 4.74e-150 462.0 COG2132@1|root,COG2132@2|Bacteria 2|Bacteria Q Multicopper oxidase - - 1.16.3.3,1.7.2.1 ko:K00368,ko:K07233,ko:K22349 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Copper-bind,Cu-oxidase_2,Cu-oxidase_3 k59_12080_1 1521187.JPIM01000015_gene3733 2.39e-59 198.0 COG0260@1|root,COG0260@2|Bacteria,2G617@200795|Chloroflexi,37528@32061|Chloroflexia 32061|Chloroflexia E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_12101_1 330214.NIDE4329 2.96e-76 244.0 COG0728@1|root,COG0728@2|Bacteria,3J0CQ@40117|Nitrospirae 40117|Nitrospirae S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_965385_1 1217720.ALOX01000004_gene4134 8.32e-106 343.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2JQPR@204441|Rhodospirillales 204441|Rhodospirillales EQ Hydantoinase/oxoprolinase N-terminal region - - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_1648649_1 742727.HMPREF9447_00363 4.61e-38 142.0 COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,2FMTU@200643|Bacteroidia,4AMK4@815|Bacteroidaceae 976|Bacteroidetes T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1383122_1 886293.Sinac_7397 7.24e-45 158.0 COG1861@1|root,COG1861@2|Bacteria,2J3F7@203682|Planctomycetes 203682|Planctomycetes M PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_4 k59_1648650_1 765910.MARPU_11875 2.72e-27 108.0 COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria,1WWMU@135613|Chromatiales 135613|Chromatiales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_1123108_1 768671.ThimaDRAFT_3401 7.34e-65 213.0 2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,1RPSZ@1236|Gammaproteobacteria,1WZX3@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_287686_1 234267.Acid_6881 6.75e-06 52.0 COG1361@1|root,COG3534@1|root,COG4625@1|root,COG1361@2|Bacteria,COG3534@2|Bacteria,COG4625@2|Bacteria,3Y354@57723|Acidobacteria 2|Bacteria M PKD domain containing protein - - 3.4.21.50 ko:K01337,ko:K20276,ko:K21449 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko02000 1.B.40.2 - - Autotransporter,DUF4347,Glyco_hydro_43,He_PIG,P_proprotein,Peptidase_S8,TIG k59_1592769_1 1198232.CYCME_0081 3.58e-106 315.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,45ZQT@72273|Thiotrichales 72273|Thiotrichales E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) - - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_1383136_1 1116472.MGMO_42c00110 8.36e-114 337.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1THGR@1236|Gammaproteobacteria,1XDV9@135618|Methylococcales 135618|Methylococcales E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1441689_2 1173028.ANKO01000052_gene1680 1.51e-102 303.0 COG0412@1|root,COG0412@2|Bacteria,1G5GK@1117|Cyanobacteria,1HF4X@1150|Oscillatoriales 1117|Cyanobacteria Q Dienelactone hydrolase family - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_1441689_3 1121374.KB891575_gene861 1.83e-68 210.0 COG3193@1|root,COG3193@2|Bacteria,1RB2H@1224|Proteobacteria,1S5K1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein possibly involved in utilization of glycolate and propanediol - - - - - - - - - - - - Haem_degrading k59_1441689_4 936455.KI421499_gene60 7.34e-70 222.0 COG3777@1|root,COG3777@2|Bacteria,1P96N@1224|Proteobacteria,2TV0U@28211|Alphaproteobacteria,3JQXP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S N-terminal half of MaoC dehydratase - - 4.2.1.153 ko:K09709 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00376 R09282 RC02479 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydrat_N,MaoC_dehydratas k59_1383138_1 330214.NIDE0547 3.88e-96 301.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1287950_1 1157490.EL26_10960 4.79e-16 72.8 COG0316@1|root,COG0316@2|Bacteria,1V6IN@1239|Firmicutes,4HKN2@91061|Bacilli,278HH@186823|Alicyclobacillaceae 91061|Bacilli S Belongs to the HesB IscA family yutM - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_1287950_2 1284352.AOIG01000007_gene2102 6.09e-21 95.5 COG0667@1|root,COG0667@2|Bacteria,1TQJC@1239|Firmicutes,4HC0W@91061|Bacilli,26W4J@186822|Paenibacillaceae 91061|Bacilli C related to aryl-alcohol dehydrogenases - - - - - - - - - - - - Aldo_ket_red k59_502037_1 450851.PHZ_c0682 1.85e-09 57.4 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,2TTA8@28211|Alphaproteobacteria,2KFN3@204458|Caulobacterales 204458|Caulobacterales H May be involved in the biosynthesis of molybdopterin - - 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_502037_2 748658.KB907319_gene764 4.98e-166 472.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1WW2B@135613|Chromatiales 135613|Chromatiales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_502037_3 2340.JV46_10490 6.75e-11 58.5 COG2920@1|root,COG2920@2|Bacteria,1NDX4@1224|Proteobacteria,1SGA8@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Part of a sulfur-relay system - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_287704_2 1121861.KB899934_gene532 3.82e-33 119.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,2TTA8@28211|Alphaproteobacteria,2JRSX@204441|Rhodospirillales 204441|Rhodospirillales H May be involved in the biosynthesis of molybdopterin moaB - 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_1232190_1 1195236.CTER_3543 1.76e-39 145.0 COG1024@1|root,COG1024@2|Bacteria,1UYQT@1239|Firmicutes,24CYI@186801|Clostridia 186801|Clostridia I enoyl-CoA hydratase - - 3.7.1.18 ko:K20765 - - - - ko00000,ko01000 - - - ECH_1 k59_756961_2 349124.Hhal_2232 5.85e-44 159.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales 135613|Chromatiales O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_502057_2 1229909.NSED_04635 4.14e-62 199.0 COG2141@1|root,arCOG02410@2157|Archaea,41SC0@651137|Thaumarchaeota 651137|Thaumarchaeota C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_86167_1 953739.SVEN_6078 1.19e-10 66.2 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase fadD5 - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_86167_2 714943.Mucpa_0158 3.35e-70 221.0 COG3970@1|root,COG3970@2|Bacteria,4NGTH@976|Bacteroidetes,1IQ0W@117747|Sphingobacteriia 976|Bacteroidetes S COGs COG3970 Fumarylacetoacetate (FAA) hydrolase family protein - - 4.2.1.141 ko:K14259 ko00040,map00040 - R09186 RC00429 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_547569_1 436308.Nmar_0676 1.2e-118 350.0 COG0039@1|root,arCOG00246@2157|Archaea,41S7Z@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the LDH MDH superfamily - - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_862887_1 1124780.ANNU01000020_gene3276 1.93e-38 146.0 COG1752@1|root,COG1752@2|Bacteria,4NF97@976|Bacteroidetes,47KND@768503|Cytophagia 976|Bacteroidetes S Esterase of the alpha-beta hydrolase superfamily - - - - - - - - - - - - Patatin k59_288896_1 1123400.KB904749_gene815 1.93e-08 57.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,45ZNE@72273|Thiotrichales 72273|Thiotrichales O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_288896_2 700598.Niako_6329 4.11e-102 303.0 COG0330@1|root,COG0330@2|Bacteria,4NFPK@976|Bacteroidetes,1IRDU@117747|Sphingobacteriia 976|Bacteroidetes O PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7 k59_1124337_1 1410620.SHLA_45c000160 1.04e-39 140.0 COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2TR65@28211|Alphaproteobacteria,4BG2Z@82115|Rhizobiaceae 28211|Alphaproteobacteria P Cation efflux family czcD - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux k59_915625_1 1196323.ALKF01000183_gene5298 9.79e-96 295.0 COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,4H9ZF@91061|Bacilli,26QJT@186822|Paenibacillaceae 91061|Bacilli C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK - 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_446797_1 870187.Thini_0322 8.06e-68 228.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,460EP@72273|Thiotrichales 72273|Thiotrichales G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1384145_1 1121413.JMKT01000009_gene2209 1.1e-66 217.0 COG2391@1|root,COG2391@2|Bacteria,1PF9B@1224|Proteobacteria,42NQX@68525|delta/epsilon subdivisions,2WKDB@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_766717_1 383372.Rcas_1948 1.84e-08 56.6 COG0159@1|root,COG0159@2|Bacteria,2G6AY@200795|Chloroflexi,374VI@32061|Chloroflexia 32061|Chloroflexia E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_766717_2 595537.Varpa_5892 8.93e-15 71.2 2E35S@1|root,32Y5P@2|Bacteria,1N6WS@1224|Proteobacteria,2VV11@28216|Betaproteobacteria,4AF6M@80864|Comamonadaceae 28216|Betaproteobacteria S Putative prokaryotic signal transducing protein - - - - - - - - - - - - DUF2007 k59_1663362_1 1266925.JHVX01000009_gene45 1.88e-58 197.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2VHX4@28216|Betaproteobacteria,372MJ@32003|Nitrosomonadales 28216|Betaproteobacteria H Belongs to the FPP GGPP synthase family ispB - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_1180865_2 330214.NIDE2415 2.56e-39 144.0 COG0248@1|root,COG2206@1|root,COG0248@2|Bacteria,COG2206@2|Bacteria,3J0K5@40117|Nitrospirae 2|Bacteria FP Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology ppx - 3.6.1.11,3.6.1.40 ko:K01524,ko:K07012 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000,ko02048 - - - HD,Helicase_C,Ppx-GppA,Response_reg k59_832644_1 56107.Cylst_2174 2.2e-64 203.0 COG4974@1|root,COG4974@2|Bacteria,1G67I@1117|Cyanobacteria,1HMGS@1161|Nostocales 1117|Cyanobacteria L PFAM Phage integrase family - - - ko:K07358 - - - - ko00000 - - - Phage_integrase k59_975795_2 1336245.JAGO01000003_gene564 1.03e-06 53.1 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1XJPG@135619|Oceanospirillales 135619|Oceanospirillales T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_1451041_1 1123236.KB899387_gene2012 2.02e-31 124.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,464IR@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641 DFP,Flavoprotein k59_1451041_2 1278309.KB907104_gene962 3.99e-09 54.7 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,1XJP4@135619|Oceanospirillales 135619|Oceanospirillales F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_98843_1 1415778.JQMM01000001_gene1282 4.04e-26 111.0 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria,1J5MY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2206 HD-GYP domain - - - - - - - - - - - - DUF3391,HD,HD_5 k59_457596_1 998674.ATTE01000001_gene1694 2.23e-96 307.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,45ZV1@72273|Thiotrichales 72273|Thiotrichales O ATP-dependent Clp protease ATP-binding subunit ClpA - - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_609666_1 1191299.AJYX01000115_gene22 1.92e-35 133.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1XSD5@135623|Vibrionales 135623|Vibrionales P Arylsulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_1663412_1 411490.ANACAC_02058 1.81e-06 50.4 COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia 186801|Clostridia F Belongs to the purine pyrimidine phosphoribosyltransferase family hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_1663412_2 903818.KI912268_gene1056 4.02e-52 176.0 COG1816@1|root,COG1816@2|Bacteria,3Y6AU@57723|Acidobacteria 57723|Acidobacteria F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism - - 3.5.4.2,3.5.4.4 ko:K01488,ko:K21053 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01244,R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase k59_1510104_1 404589.Anae109_2130 1.56e-44 157.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2WIPG@28221|Deltaproteobacteria,2YU3H@29|Myxococcales 28221|Deltaproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_187600_1 502025.Hoch_6598 1.94e-72 233.0 COG0493@1|root,COG0493@2|Bacteria,1P58U@1224|Proteobacteria,4392A@68525|delta/epsilon subdivisions,2X47Z@28221|Deltaproteobacteria,2YYG2@29|Myxococcales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - Pyr_redox_2 k59_1302567_1 1026882.MAMP_01764 1.22e-122 359.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,45ZSW@72273|Thiotrichales 72273|Thiotrichales J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_717322_1 1122139.KB907890_gene299 1.87e-74 247.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1XH2S@135619|Oceanospirillales 135619|Oceanospirillales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_832732_1 765420.OSCT_2028 1.21e-72 244.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G7K6@200795|Chloroflexi,374W8@32061|Chloroflexia 32061|Chloroflexia G SMART alpha amylase, catalytic sub domain - - 3.2.1.1,3.2.1.20,5.4.99.16 ko:K01187,ko:K05343 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R01557,R02108,R02112,R06087,R06088,R11262 RC00028,RC00049,RC00077,RC01816 ko00000,ko00001,ko01000 - GH13,GH31 - Alpha-amylase,Malt_amylase_C k59_975843_1 1121936.AUHI01000002_gene2663 8.78e-90 284.0 COG0028@1|root,COG0028@2|Bacteria,1UYHG@1239|Firmicutes 1239|Firmicutes EH Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1302581_1 90814.KL370891_gene747 7.4e-28 105.0 2BZMS@1|root,32Z9B@2|Bacteria,1NCFD@1224|Proteobacteria,1SPFN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3467) - - - - - - - - - - - - DUF3467 k59_1392565_1 1460634.JCM19037_3596 2.68e-05 48.9 COG5276@1|root,COG5276@2|Bacteria,1UUVN@1239|Firmicutes,4HBJX@91061|Bacilli 91061|Bacilli S LVIVD repeat - - - - - - - - - - - - LVIVD k59_1663460_1 589924.Ferp_2180 3.02e-51 182.0 COG0365@1|root,arCOG06122@2157|Archaea,2Y84J@28890|Euryarchaeota,246YJ@183980|Archaeoglobi 183980|Archaeoglobi I AMP-binding enzyme C-terminal domain - - 6.2.1.32 ko:K08295 ko00627,ko01120,map00627,map01120 - R00982 RC00004,RC00174 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_558228_2 247634.GPB2148_96 2.49e-57 198.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria,1SMN0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1542525_1 1084719.G3MAX4_9CAUD 1.06e-09 64.3 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae 10662|Myoviridae S Type III restriction enzyme, res subunit - - - - - - - - - - - - - k59_1337164_2 1122614.JHZF01000011_gene1663 2.14e-09 60.1 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - - - - - - - - - - - ECH_1 k59_98921_1 335543.Sfum_3370 5.99e-74 235.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2WJ3T@28221|Deltaproteobacteria,2MQAM@213462|Syntrophobacterales 28221|Deltaproteobacteria C Belongs to the UDP-glucose GDP-mannose dehydrogenase family ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_98921_2 227377.CBU_0826 3.27e-06 47.4 COG0250@1|root,COG0250@2|Bacteria,1N01W@1224|Proteobacteria,1S91B@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho- dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains rfaH GO:0001000,GO:0001073,GO:0001121,GO:0001124,GO:0003674,GO:0003676,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008494,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031554,GO:0031564,GO:0032268,GO:0032270,GO:0032774,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045182,GO:0045727,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090079,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K05785 - - - - ko00000,ko03000 - - - NusG k59_675642_1 261292.Nit79A3_1669 1.92e-17 81.6 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,372B6@32003|Nitrosomonadales 28216|Betaproteobacteria P Belongs to the ABC transporter superfamily dppF - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_675642_2 985867.AEWF01000007_gene389 1.62e-44 149.0 COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,2U93J@28211|Alphaproteobacteria,47G63@766|Rickettsiales 766|Rickettsiales I Thioesterase superfamily - - - ko:K10806 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT k59_187649_1 298386.PBPRA1265 1.86e-61 207.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1RMHR@1236|Gammaproteobacteria,1XUC7@135623|Vibrionales 135623|Vibrionales Q COG2015 Alkyl sulfatase and related hydrolases - - - ko:K01138 - - - - ko00000,ko01000 - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_1451110_1 234267.Acid_1563 3.95e-24 95.9 COG0720@1|root,COG0720@2|Bacteria,3Y4K2@57723|Acidobacteria 57723|Acidobacteria H PFAM 6-pyruvoyl tetrahydropterin - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_1451110_2 1236501.BAJU01000001_gene91 2.43e-10 60.5 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2TT7W@28211|Alphaproteobacteria,2JQV9@204441|Rhodospirillales 204441|Rhodospirillales K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_1511672_2 710685.MycrhN_6228 2.49e-48 168.0 COG2124@1|root,COG2124@2|Bacteria,2GNJI@201174|Actinobacteria,235VS@1762|Mycobacteriaceae 201174|Actinobacteria C Cytochrome P450 - - - - - - - - - - - - p450 k59_1244803_1 195250.CM001776_gene3165 6.52e-58 191.0 COG0438@1|root,COG0438@2|Bacteria,1GE3D@1117|Cyanobacteria 1117|Cyanobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_1244803_2 1121957.ATVL01000009_gene1106 2.2e-07 56.6 COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,4NGJ4@976|Bacteroidetes,47KIQ@768503|Cytophagia 976|Bacteroidetes G Trehalose-phosphatase otsB - 2.4.1.15,3.1.3.12 ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,Trehalose_PPase k59_1602612_1 58123.JOFJ01000012_gene5351 1.33e-10 67.8 COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria,4EFZ8@85012|Streptosporangiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1665027_2 1429916.X566_12030 9e-15 74.3 COG1028@1|root,COG1028@2|Bacteria,1R4GG@1224|Proteobacteria,2VF4X@28211|Alphaproteobacteria,3K5YF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_1511677_1 387092.NIS_1547 6.74e-84 264.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2YMF9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_7,Pribosyltran k59_1029390_1 123214.PERMA_0268 1.2e-59 197.0 COG0158@1|root,COG0158@2|Bacteria,2G3QQ@200783|Aquificae 200783|Aquificae G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 fbp - 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase k59_1543666_2 335283.Neut_1955 4.75e-10 59.3 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2VIT9@28216|Betaproteobacteria,372CZ@32003|Nitrosomonadales 28216|Betaproteobacteria H The glycine cleavage system catalyzes the degradation of glycine gcvT GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_188738_1 1380350.JIAP01000012_gene423 5.51e-31 127.0 COG1409@1|root,COG2931@1|root,COG3204@1|root,COG1409@2|Bacteria,COG2931@2|Bacteria,COG3204@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,43I5T@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - 3.4.24.40 ko:K01406,ko:K07004 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - An_peroxidase,Cadherin,Calx-beta,Exo_endo_phos,HemolysinCabind,Metallophos,Peptidase_M10_C k59_1338084_1 228405.HNE_1260 1.68e-74 244.0 COG3540@1|root,COG3540@2|Bacteria,1MWAF@1224|Proteobacteria,2U0FQ@28211|Alphaproteobacteria,43WGM@69657|Hyphomonadaceae 28211|Alphaproteobacteria P COG3540 Phosphodiesterase alkaline phosphatase D - - 3.1.3.1 ko:K01077,ko:K01113 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - PhoD,PhoD_N k59_928423_1 338963.Pcar_1708 0.000144 51.2 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2WJTY@28221|Deltaproteobacteria,43S3Q@69541|Desulfuromonadales 28221|Deltaproteobacteria L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_1511734_1 428125.CLOLEP_02910 2.83e-31 119.0 COG0217@1|root,COG0217@2|Bacteria,1TPP5@1239|Firmicutes,247NK@186801|Clostridia,3WHDN@541000|Ruminococcaceae 186801|Clostridia K Transcriptional regulatory protein yebC - - - - - - - - - - - Transcrip_reg k59_977017_1 330214.NIDE3300 3.76e-103 308.0 COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae 2|Bacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - FGE-sulfatase k59_1665096_2 716928.AJQT01000109_gene1226 4.77e-55 177.0 COG3772@1|root,COG3772@2|Bacteria,1MZJD@1224|Proteobacteria,2U7RQ@28211|Alphaproteobacteria,4BAG3@82115|Rhizobiaceae 28211|Alphaproteobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - Phage_lysozyme k59_353527_1 398525.KB900701_gene3263 6.74e-52 176.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2TVNW@28211|Alphaproteobacteria,3JX9Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Ring hydroxylating alpha subunit (catalytic domain) - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_677277_1 502025.Hoch_0348 1.1e-57 192.0 COG1621@1|root,COG1621@2|Bacteria,1RCMP@1224|Proteobacteria,432Y7@68525|delta/epsilon subdivisions 1224|Proteobacteria G beta-fructofuranosidase activity - - - - - - - - - - - - - k59_1393510_1 1192034.CAP_7398 5.21e-66 226.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,42MFX@68525|delta/epsilon subdivisions,2WJ91@28221|Deltaproteobacteria,2YU35@29|Myxococcales 28221|Deltaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_677283_1 272560.BPSL0745 1.54e-07 57.4 2EHBJ@1|root,33B3E@2|Bacteria,1NNJX@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1602657_1 1382303.JPOM01000001_gene736 5.08e-93 287.0 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,2KFVB@204458|Caulobacterales 204458|Caulobacterales V beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_977039_2 66875.JODY01000006_gene2209 4.25e-20 89.4 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria 201174|Actinobacteria J Belongs to the amidase family amiC_1 - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_1462373_1 1207076.ALAT01000183_gene3046 1.76e-26 110.0 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria,1Z1U9@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N k59_1095509_1 187272.Mlg_0587 5.99e-49 177.0 COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales 135613|Chromatiales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_939066_1 1116472.MGMO_26c00030 5.4e-11 61.6 COG1842@1|root,COG1842@2|Bacteria 2|Bacteria KT Phage shock protein A - - - ko:K03615,ko:K03969,ko:K09749,ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60,PspA_IM30 k59_939066_2 1408428.JNJP01000028_gene641 1.6e-06 50.4 COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,42QH5@68525|delta/epsilon subdivisions,2WMMF@28221|Deltaproteobacteria,2MG4H@213115|Desulfovibrionales 28221|Deltaproteobacteria K Two component transcriptional regulator, winged helix family colR - - - - - - - - - - - Response_reg,Trans_reg_C k59_1403730_1 448385.sce4587 1.62e-19 92.4 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,43C0J@68525|delta/epsilon subdivisions,2X7B7@28221|Deltaproteobacteria,2YUMJ@29|Myxococcales 28221|Deltaproteobacteria KLT Serine Threonine protein kinase - - - - - - - - - - - - AAA_16,Pkinase k59_1348410_1 1038862.KB893843_gene453 1.87e-62 216.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_1610386_1 1229909.NSED_00600 8.38e-36 127.0 COG2266@1|root,arCOG01871@2157|Archaea,41SRI@651137|Thaumarchaeota 651137|Thaumarchaeota M MobA-like NTP transferase domain - - 2.7.7.62 ko:K19712 ko00860,ko01100,map00860,map01100 - R05222 RC00002 ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_1610386_2 1229909.NSED_00605 7.46e-35 119.0 COG2051@1|root,arCOG04108@2157|Archaea,41SUD@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein rps27e - - ko:K02978 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S27e k59_776908_1 1229909.NSED_07175 7.76e-30 114.0 COG0119@1|root,arCOG02092@2157|Archaea,41S7Y@651137|Thaumarchaeota 651137|Thaumarchaeota E HMGL-like - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_776908_2 436308.Nmar_1294 1.47e-35 120.0 arCOG01588@1|root,arCOG01588@2157|Archaea,41STK@651137|Thaumarchaeota 651137|Thaumarchaeota E lysine biosynthesis protein LysW - - - ko:K05826 - M00031,M00763 - - ko00000,ko00001,ko00002 - - - - k59_776908_3 1229909.NSED_07185 2.71e-30 113.0 COG0189@1|root,arCOG01589@2157|Archaea,41SE8@651137|Thaumarchaeota 651137|Thaumarchaeota H Lysine biosynthesis - - 6.3.2.43 ko:K05827 ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230 M00031 R09775 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - RimK k59_1149074_1 160799.PBOR_25910 4.09e-14 77.0 COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,4HBC7@91061|Bacilli,26SDU@186822|Paenibacillaceae 91061|Bacilli G Alpha-mannosidase - - 2.3.1.204,3.2.1.24 ko:K01191,ko:K16869 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C k59_622304_1 3218.PP1S173_154V6.1 1.59e-52 173.0 COG1028@1|root,KOG0725@2759|Eukaryota,37ZA0@33090|Viridiplantae,3GNSG@35493|Streptophyta 35493|Streptophyta Q KR domain - - - - - - - - - - - - adh_short_C2 k59_22382_1 583345.Mmol_1395 1.02e-22 103.0 COG2204@1|root,COG4963@1|root,COG2204@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,2VNYQ@28216|Betaproteobacteria,2KNDN@206350|Nitrosomonadales 206350|Nitrosomonadales D Cellulose biosynthesis protein BcsQ - - - ko:K02282 - - - - ko00000,ko02035,ko02044 - - - AAA_31,Response_reg k59_200249_1 909663.KI867150_gene213 9.89e-54 192.0 COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria,2MRCI@213462|Syntrophobacterales 28221|Deltaproteobacteria M PFAM Tetratricopeptide repeat - - - - - - - - - - - - PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_255799_1 748280.NH8B_2624 1.22e-42 154.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2VHJ4@28216|Betaproteobacteria,2KPRN@206351|Neisseriales 206351|Neisseriales S TldD PmbA family protein pmbA - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1192251_1 744872.Spica_2293 1.81e-23 95.5 COG2077@1|root,COG2077@2|Bacteria,2J8GN@203691|Spirochaetes 203691|Spirochaetes O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - Redoxin k59_1192251_2 323848.Nmul_A0210 1.69e-13 70.5 COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2VHQ6@28216|Betaproteobacteria,37240@32003|Nitrosomonadales 28216|Betaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPB - 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - Aminotran_5,GDC-P k59_939088_1 42099.EPrPV00000019731 3.48e-09 69.7 COG3914@1|root,KOG4626@2759|Eukaryota,1MG2G@121069|Pythiales 121069|Pythiales GOT UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kDa subunit. Source PGD - - - - - - - - - - - - Glyco_transf_41,TPR_16 k59_417408_1 102129.Lepto7375DRAFT_8161 5.12e-29 120.0 COG2274@1|root,COG2274@2|Bacteria,1FZZ2@1117|Cyanobacteria,1H760@1150|Oscillatoriales 1117|Cyanobacteria V N-terminal double-glycine peptidase domain hetC - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran,Peptidase_C39,cNMP_binding k59_417427_1 28072.Nos7524_2009 8.37e-06 53.9 COG2304@1|root,COG3209@1|root,COG4932@1|root,COG2304@2|Bacteria,COG3209@2|Bacteria,COG4932@2|Bacteria,1GPZZ@1117|Cyanobacteria,1HJUW@1161|Nostocales 1117|Cyanobacteria M Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - RHS_repeat,VWA k59_988211_1 497964.CfE428DRAFT_1237 2.69e-82 258.0 COG1032@1|root,COG1032@2|Bacteria 2|Bacteria C radical SAM domain protein - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_988216_1 330214.NIDE1006 1.62e-64 211.0 COG3391@1|root,COG3391@2|Bacteria,3J19W@40117|Nitrospirae 2|Bacteria S NHL repeat - - - - - - - - - - - - Cadherin,NHL,TIG k59_883790_1 398579.Spea_3282 1.26e-29 115.0 COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,1RR3K@1236|Gammaproteobacteria,2Q9B0@267890|Shewanellaceae 1236|Gammaproteobacteria P PFAM Na H antiporter MnhB subunit-related protein - - - ko:K05566 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040,MnhB k59_883790_2 1123355.JHYO01000024_gene1813 5.66e-51 167.0 COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,2U7UT@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG2111 Multisubunit Na H antiporter, MnhB subunit - - - ko:K05566 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040 k59_1194449_1 3694.POPTR_0012s05040.1 1.91e-52 181.0 COG4948@1|root,2QU7C@2759|Eukaryota,37SAV@33090|Viridiplantae,3G9Q6@35493|Streptophyta,4JJ36@91835|fabids 35493|Streptophyta M L-Ala-D L-amino acid - GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_988240_1 1122176.KB903598_gene4621 1.81e-73 241.0 COG0332@1|root,COG0332@2|Bacteria 2|Bacteria I beta-ketoacyl-acyl-carrier-protein synthase III activity - - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_729308_1 1121935.AQXX01000104_gene401 5.35e-68 225.0 COG0642@1|root,COG2205@2|Bacteria,1MXH7@1224|Proteobacteria,1RQZW@1236|Gammaproteobacteria,1XJBY@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase-like ATPases - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_570268_1 436308.Nmar_1110 1.04e-91 275.0 COG1454@1|root,arCOG00984@2157|Archaea,41SFC@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Iron-containing alcohol dehydrogenase - - - ko:K18602 ko00720,ko01120,map00720,map01120 - R09289 RC00087 ko00000,ko00001,ko01000 - - - Fe-ADH k59_570268_2 1229909.NSED_06435 2.19e-18 82.8 COG2141@1|root,arCOG02410@2157|Archaea,41SBM@651137|Thaumarchaeota 651137|Thaumarchaeota C Luciferase-like monooxygenase - - - ko:K14728 - - - - ko00000,ko01000 - - - Bac_luciferase k59_624653_1 314271.RB2654_12074 6.35e-117 350.0 COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2TQZC@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1040190_1 926550.CLDAP_14190 3.42e-51 167.0 COG1945@1|root,COG1945@2|Bacteria 2|Bacteria I arginine decarboxylase activity pdaD - 4.1.1.19 ko:K02626 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PvlArgDC k59_1405986_1 1335757.SPICUR_03170 1.55e-29 109.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,1WY5U@135613|Chromatiales 135613|Chromatiales K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_1405986_2 187272.Mlg_1981 6.77e-32 124.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1WVW8@135613|Chromatiales 135613|Chromatiales EF Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_202611_1 471852.Tcur_1250 5.72e-98 294.0 COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4EQRC@85012|Streptosporangiales 201174|Actinobacteria C Luciferase-like monooxygenase - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Bac_luciferase k59_1405996_1 760568.Desku_0156 4.27e-90 279.0 COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia,2615A@186807|Peptococcaceae 186801|Clostridia E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT_4,PALP k59_624691_1 1125863.JAFN01000001_gene352 1.62e-49 170.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,42KZG@68525|delta/epsilon subdivisions,2WIQ5@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_417545_1 96561.Dole_1053 3.92e-30 112.0 COG2128@1|root,COG2128@2|Bacteria,1PSNE@1224|Proteobacteria,42XCT@68525|delta/epsilon subdivisions,2WSJD@28221|Deltaproteobacteria,2MP2A@213118|Desulfobacterales 28221|Deltaproteobacteria S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD k59_417545_2 1114964.L485_21335 5.66e-27 110.0 COG2159@1|root,COG2159@2|Bacteria,1R4UN@1224|Proteobacteria,2U2QQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_729353_1 396588.Tgr7_0776 8.13e-98 291.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1WW5R@135613|Chromatiales 135613|Chromatiales M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_624692_2 34506.g2532 2.73e-72 237.0 COG0240@1|root,KOG2711@2759|Eukaryota,39XXB@33154|Opisthokonta,3BXF0@33208|Metazoa,3DD4H@33213|Bilateria 33208|Metazoa C Glycerol-3-phosphate dehydrogenase - - - - - - - - - - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_883843_1 95619.PM1_0230095 2.76e-71 233.0 COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,1S174@1236|Gammaproteobacteria 1236|Gammaproteobacteria EGP Major Facilitator - - - - - - - - - - - - Sugar_tr k59_988357_1 639283.Snov_0057 1.89e-23 96.3 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2U797@28211|Alphaproteobacteria,3EZ96@335928|Xanthobacteraceae 28211|Alphaproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.31,3.5.1.88 ko:K01450,ko:K01462 ko00270,ko00630,map00270,map00630 - R00653 RC00165,RC00323 ko00000,ko00001,ko01000 - - - Pep_deformylase k59_624734_1 383372.Rcas_1197 3.53e-13 70.9 COG5394@1|root,COG5394@2|Bacteria,2G77C@200795|Chloroflexi,375VS@32061|Chloroflexia 32061|Chloroflexia K PFAM PHA accumulation regulator DNA-binding protein - - - - - - - - - - - - PHB_acc_N k59_417598_1 1173028.ANKO01000056_gene2196 1.76e-39 152.0 COG4191@1|root,COG4191@2|Bacteria,1G07W@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_9 k59_1040227_3 744980.TRICHSKD4_0980 4.56e-176 499.0 COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TSRF@28211|Alphaproteobacteria 28211|Alphaproteobacteria ET COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain aapJ GO:0005575,GO:0005623,GO:0042597,GO:0044464 - ko:K09969 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - SBP_bac_3 k59_1040227_4 1121935.AQXX01000133_gene3541 9.11e-48 166.0 COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,1RN6V@1236|Gammaproteobacteria,1XIIE@135619|Oceanospirillales 135619|Oceanospirillales P amino acid ABC transporter aapQ - - ko:K09970 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_1194532_1 555778.Hneap_0663 2.26e-113 331.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1WWZU@135613|Chromatiales 135613|Chromatiales M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_23159_1 1123253.AUBD01000005_gene165 8.8e-10 65.9 COG2234@1|root,COG2234@2|Bacteria,1NE83@1224|Proteobacteria,1RN9P@1236|Gammaproteobacteria,1X3HG@135614|Xanthomonadales 135614|Xanthomonadales S aminopeptidase - - - - - - - - - - - - Peptidase_M28 k59_417614_1 395493.BegalDRAFT_3365 6.72e-69 219.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,460J2@72273|Thiotrichales 72273|Thiotrichales F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_417614_2 1123034.JMKP01000005_gene825 0.000147 44.7 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,3NKDH@468|Moraxellaceae 1236|Gammaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB GO:0000166,GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3389,iBWG_1329.BWG_3080,iECDH10B_1368.ECDH10B_3564,iECDH1ME8569_1439.ECDH1ME8569_3268,iECNA114_1301.ECNA114_3486,iEcDH1_1363.EcDH1_0324,iJO1366.b3389,iJR904.b3389,iY75_1357.Y75_RS20275 DHQ_synthase k59_988393_2 864073.HFRIS_010009 6.77e-30 115.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2VH9Q@28216|Betaproteobacteria,47351@75682|Oxalobacteraceae 28216|Betaproteobacteria F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_1194556_1 1415780.JPOG01000001_gene696 1.18e-85 279.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,1X621@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_988416_1 1117108.PAALTS15_02082 0.000426 47.4 COG0664@1|root,COG0664@2|Bacteria,1TTDQ@1239|Firmicutes,4I7XF@91061|Bacilli,26Y0Z@186822|Paenibacillaceae 91061|Bacilli T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_1040251_1 1085623.GNIT_3235 1.89e-118 356.0 COG3250@1|root,COG3250@2|Bacteria,1R8R6@1224|Proteobacteria,1RZM7@1236|Gammaproteobacteria,4660T@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glycosyl hydrolases family 2, TIM barrel domain - - - - - - - - - - - - Glyco_hydro_2_C k59_624804_1 1408419.JHYG01000005_gene670 7.55e-14 83.2 COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,2U26R@28211|Alphaproteobacteria,2JPQ3@204441|Rhodospirillales 204441|Rhodospirillales M AsmA family - - - ko:K07289,ko:K07290 - - - - ko00000 9.B.121 - - AsmA,AsmA_2 k59_570380_1 941449.dsx2_3134 2.1e-31 117.0 COG2080@1|root,COG2080@2|Bacteria,1N1KQ@1224|Proteobacteria,42UD3@68525|delta/epsilon subdivisions,2WPH9@28221|Deltaproteobacteria,2M9N0@213115|Desulfovibrionales 28221|Deltaproteobacteria C 2Fe-2S -binding - - - - - - - - - - - - Fer2,Fer2_2 k59_570381_1 644282.Deba_3090 4.84e-75 241.0 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42NH8@68525|delta/epsilon subdivisions,2WJMA@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase - - - - - - - - - - - - Bac_transf,CoA_binding_3 k59_883908_1 338963.Pcar_2001 1.44e-43 160.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42N1H@68525|delta/epsilon subdivisions,2WJ0R@28221|Deltaproteobacteria,43SBR@69541|Desulfuromonadales 28221|Deltaproteobacteria C Inorganic H+ pyrophosphatase hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_883910_2 1454004.AW11_00065 7.58e-43 152.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2VIIH@28216|Betaproteobacteria 28216|Betaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1611900_1 1173023.KE650771_gene5565 1.58e-128 377.0 COG3344@1|root,COG3344@2|Bacteria,1G065@1117|Cyanobacteria,1JHHS@1189|Stigonemataceae 1117|Cyanobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,HNH,RVT_1,RVT_N k59_23185_1 247634.GPB2148_1120 3.43e-49 173.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1J88C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.99.10 ko:K22445 - - - - ko00000,ko01000 - - - Aldedh k59_1350806_1 1461693.ATO10_01465 4.7e-24 103.0 COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2TR20@28211|Alphaproteobacteria 28211|Alphaproteobacteria H ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity - - - ko:K06048 - - - - ko00000,ko01000 - - - GCS2 k59_1406112_1 626418.bglu_2g01040 4.89e-05 47.0 COG0665@1|root,COG0665@2|Bacteria,1MU7M@1224|Proteobacteria,2VPYG@28216|Betaproteobacteria,1JZQX@119060|Burkholderiaceae 28216|Betaproteobacteria E fad dependent oxidoreductase - - - - - - - - - - - - DAO k59_1406112_2 551789.ATVJ01000002_gene3008 3.4e-36 124.0 COG4327@1|root,COG4327@2|Bacteria,1N0TK@1224|Proteobacteria,2UC3P@28211|Alphaproteobacteria,43Y3N@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF4212) - - - - - - - - - - - - DUF4212 k59_1406112_3 551275.KB899544_gene1453 7.41e-22 94.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2TTA4@28211|Alphaproteobacteria,43WAA@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_883961_1 1395571.TMS3_0119330 2.04e-69 221.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_624932_1 748247.AZKH_p0222 7.17e-91 280.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria,2KX8V@206389|Rhodocyclales 206389|Rhodocyclales L Group II intron, maturase-specific domain - - - - - - - - - - - - GIIM,RVT_1 k59_1557350_1 765911.Thivi_2160 1.35e-27 101.0 COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,1SCFA@1236|Gammaproteobacteria,1WYVX@135613|Chromatiales 135613|Chromatiales O Belongs to the sulfur carrier protein TusA family - - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - TusA k59_1406150_1 1387312.BAUS01000010_gene155 2.13e-90 294.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,2KKNG@206350|Nitrosomonadales 206350|Nitrosomonadales J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N,IF2_assoc k59_257446_1 1255043.TVNIR_2333 3.18e-90 276.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,1RMJC@1236|Gammaproteobacteria,1WWJN@135613|Chromatiales 135613|Chromatiales F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_988586_2 457398.HMPREF0326_01433 6.03e-58 199.0 COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2M8FJ@213115|Desulfovibrionales 28221|Deltaproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_1557378_1 656024.FsymDg_1437 1.06e-08 55.8 COG0071@1|root,COG0071@2|Bacteria,2IRG0@201174|Actinobacteria 201174|Actinobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_1557378_2 1538644.KO02_20805 8.47e-13 68.9 COG0489@1|root,COG0489@2|Bacteria,4NF5I@976|Bacteroidetes,1IQKF@117747|Sphingobacteriia 976|Bacteroidetes D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_417826_1 1049564.TevJSym_bo00090 1.13e-128 382.0 COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,1RR3N@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG2010 Cytochrome c, mono- and diheme variants nirN - - - - - - - - - - - Cytochrom_D1,Cytochrome_CBB3 k59_892493_2 1121372.AULK01000007_gene417 2.61e-06 49.3 COG4221@1|root,COG4221@2|Bacteria,2I2YS@201174|Actinobacteria,4FKTS@85023|Microbacteriaceae 201174|Actinobacteria S KR domain - - - - - - - - - - - - adh_short k59_422225_1 351348.Maqu_3123 1.63e-89 274.0 COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,1RYUT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Heme d1 biosynthesis protein NirF nirF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K19345 - - - - ko00000 - - - Cytochrom_D1 k59_1049067_1 1120956.JHZK01000001_gene3449 9.44e-33 127.0 29ISC@1|root,2Z7VE@2|Bacteria,1MWUK@1224|Proteobacteria,2TTFU@28211|Alphaproteobacteria,1JPZS@119043|Rhodobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - DUF3604 k59_1049067_3 323848.Nmul_A1979 4.86e-39 142.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2VI16@28216|Betaproteobacteria,372H1@32003|Nitrosomonadales 28216|Betaproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_526557_1 1131266.ARWQ01000008_gene341 2.38e-108 325.0 COG0439@1|root,arCOG01590@2157|Archaea,41SXC@651137|Thaumarchaeota 651137|Thaumarchaeota I Carbamoyl-phosphate synthase L chain - - 6.4.1.2,6.4.1.3 ko:K18603 ko00720,ko01120,map00720,map01120 - R00742,R01859 RC00040,RC00097,RC00367,RC00609 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_1362500_1 977880.RALTA_A1536 3.27e-44 162.0 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria 28216|Betaproteobacteria E Spermine/spermidine synthase domain - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_1153389_2 1163408.UU9_10779 1.3e-16 80.9 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1X55Q@135614|Xanthomonadales 135614|Xanthomonadales EH component I pabB - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_318090_1 1121127.JAFA01000036_gene3620 1.83e-34 133.0 COG1615@1|root,COG1615@2|Bacteria,1MZ5A@1224|Proteobacteria,2W1FV@28216|Betaproteobacteria,1K502@119060|Burkholderiaceae 28216|Betaproteobacteria S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 k59_1362510_1 313589.JNB_15588 0.000334 43.5 COG2197@1|root,COG2197@2|Bacteria,2GJRY@201174|Actinobacteria,4FGN8@85021|Intrasporangiaceae 201174|Actinobacteria T LuxR family transcriptional regulator - - - - - - - - - - - - GerE,Response_reg k59_1362510_2 316067.Geob_1139 3.32e-14 72.0 COG0593@1|root,COG1943@1|root,COG0593@2|Bacteria,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42RDM@68525|delta/epsilon subdivisions 1224|Proteobacteria L Chromosomal replication initiator, DnaA - - - ko:K07491 - - - - ko00000 - - - Bac_DnaA_C,Y1_Tnp k59_422243_1 330214.NIDE3286 4e-58 189.0 COG0341@1|root,COG0341@2|Bacteria,3J0GM@40117|Nitrospirae 40117|Nitrospirae U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_422243_2 330214.NIDE3287 3.56e-07 50.8 COG0342@1|root,COG0342@2|Bacteria,3J09Z@40117|Nitrospirae 40117|Nitrospirae U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_1623652_1 357808.RoseRS_0699 1.42e-71 236.0 COG0260@1|root,COG0260@2|Bacteria,2G617@200795|Chloroflexi,37528@32061|Chloroflexia 32061|Chloroflexia E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_1049089_1 42256.RradSPS_0358 3.92e-60 208.0 COG2909@1|root,COG2909@2|Bacteria,2HENR@201174|Actinobacteria,4CPC9@84995|Rubrobacteria 84995|Rubrobacteria K helix_turn_helix, Lux Regulon - - - ko:K03556 - - - - ko00000,ko03000 - - - AAA_16,AAA_22,GerE k59_788848_1 1163730.FFONT_0962 1.27e-47 169.0 COG0430@1|root,arCOG04125@2157|Archaea,2XPT6@28889|Crenarchaeota 28889|Crenarchaeota J Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP rtcA GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098 6.5.1.4 ko:K01974 - - - - ko00000,ko01000 - - - RTC,RTC_insert k59_788848_2 1229909.NSED_09220 2.87e-80 241.0 COG1056@1|root,arCOG00972@2157|Archaea,41T7B@651137|Thaumarchaeota 651137|Thaumarchaeota H Cytidylyltransferase-like - - 2.7.7.1 ko:K00952 ko00760,ko01100,map00760,map01100 - R00137,R03005 RC00002 ko00000,ko00001,ko01000 - - - CTP_transf_like k59_1571089_1 247634.GPB2148_3772 1.13e-26 101.0 COG1917@1|root,COG1917@2|Bacteria,1N0G1@1224|Proteobacteria,1SDYY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Pfam Cupin - - - - - - - - - - - - Cupin_2 k59_1258967_1 118166.JH976537_gene2120 2.75e-90 271.0 COG1028@1|root,COG1028@2|Bacteria,1GPXQ@1117|Cyanobacteria 1117|Cyanobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1414544_2 85643.Tmz1t_1095 5.95e-20 93.6 COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,2KUX8@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the peptidase S11 family pbp - - ko:K07262 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S11 k59_578921_1 323261.Noc_2060 1.24e-48 165.0 COG2345@1|root,COG2345@2|Bacteria,1RDXT@1224|Proteobacteria,1S4DW@1236|Gammaproteobacteria,1X1P9@135613|Chromatiales 135613|Chromatiales K IclR helix-turn-helix domain - - - - - - - - - - - - HTH_24 k59_684386_2 1278073.MYSTI_06758 8.44e-149 431.0 COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,42N88@68525|delta/epsilon subdivisions,2WISX@28221|Deltaproteobacteria,2YU3P@29|Myxococcales 28221|Deltaproteobacteria E Serine dehydratase beta chain sdaA - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha,SDH_beta k59_474224_1 1049564.TevJSym_aq00680 1.44e-83 254.0 COG4660@1|root,COG4660@2|Bacteria,1R342@1224|Proteobacteria,1T62W@1236|Gammaproteobacteria,1JBVX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport rnfE2 - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_474224_2 1049564.TevJSym_aq00690 1.44e-40 142.0 COG4659@1|root,COG4659@2|Bacteria,1REZV@1224|Proteobacteria,1T054@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport - - - - - - - - - - - - FMN_bind k59_1571105_1 1120963.KB894501_gene207 5.91e-81 258.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,2Q0TS@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0006970,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009268,GO:0009409,GO:0009628,GO:0009651,GO:0009987,GO:0010467,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043021,GO:0043023,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_1623673_1 1121939.L861_22670 4e-50 168.0 COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,1RYRW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 k59_1623673_2 396588.Tgr7_0122 7.83e-169 486.0 COG1488@1|root,COG1488@2|Bacteria 2|Bacteria H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP pncB GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - iYO844.BSU31750 NAPRTase k59_1414559_1 1348657.M622_04455 4.47e-12 66.6 COG5361@1|root,COG5361@2|Bacteria,1PF7H@1224|Proteobacteria,2VK8N@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF1214) - - - - - - - - - - - - DUF1214 k59_1414559_2 247156.NFA_22130 1.24e-22 97.1 COG2141@1|root,COG2141@2|Bacteria,2GM7W@201174|Actinobacteria,4FXTF@85025|Nocardiaceae 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_159704_1 395493.BegalDRAFT_1798 3.94e-54 183.0 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,460FI@72273|Thiotrichales 72273|Thiotrichales G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB - - ko:K19804 - - - - ko00000 - - - TPR_16 k59_944252_1 2340.JV46_27250 2.9e-54 191.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1J4N3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) mrcB GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008289,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042277,GO:0042546,GO:0042597,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071723,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iECIAI39_1322.ECIAI39_0153,iSBO_1134.SBO_0138,iSbBS512_1146.SbBS512_E0140,iYL1228.KPN_00164 PBP1_TM,Transgly,Transpeptidase,UB2H k59_1414569_1 63737.Npun_F5467 7.05e-23 102.0 COG2202@1|root,COG3852@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3852@2|Bacteria,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria,1HTQ5@1161|Nostocales 1117|Cyanobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - CHASE4,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_318140_2 754476.Q7A_2407 3.83e-20 86.7 COG4967@1|root,COG4967@2|Bacteria,1N6TG@1224|Proteobacteria,1SC9Z@1236|Gammaproteobacteria,462UH@72273|Thiotrichales 72273|Thiotrichales NU Pfam:N_methyl_2 - - - ko:K02671 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_1259006_2 1123020.AUIE01000007_gene3368 9.08e-31 123.0 COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,1S8ED@1236|Gammaproteobacteria,1YDIA@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Conserved TM helix - - - - - - - - - - - - MS_channel,TM_helix k59_1259006_3 698758.AXY_17780 1.73e-13 76.6 COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,4HASP@91061|Bacilli 91061|Bacilli P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_996449_1 866895.HBHAL_2134 3.99e-78 249.0 COG0388@1|root,COG0454@1|root,COG0388@2|Bacteria,COG0456@2|Bacteria,1TQAZ@1239|Firmicutes,4HCQW@91061|Bacilli,3NFQW@45667|Halobacillus 91061|Bacilli K Carbon-nitrogen hydrolase yhcX - - - - - - - - - - - Acetyltransf_1,CN_hydrolase k59_944257_1 665942.HMPREF1022_00584 1.39e-93 289.0 COG3616@1|root,COG3616@2|Bacteria,1N2SF@1224|Proteobacteria,43DN3@68525|delta/epsilon subdivisions,2X6EU@28221|Deltaproteobacteria,2MAKE@213115|Desulfovibrionales 28221|Deltaproteobacteria E alanine racemase domain protein - - 4.3.1.27 ko:K20757 - - - - ko00000,ko01000 - - - Ala_racemase_N,D-ser_dehydrat k59_944257_2 105420.BBPO01000032_gene6514 5.37e-10 66.6 COG0451@1|root,COG0451@2|Bacteria,2GP24@201174|Actinobacteria,2NEQC@228398|Streptacidiphilus 201174|Actinobacteria GM Male sterility protein - - - - - - - - - - - - Epimerase k59_735654_1 1049564.TevJSym_ac00670 1.48e-65 219.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,1RMR1@1236|Gammaproteobacteria,1J9NQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Pyrroloquinoline quinone biosynthesis protein E pqqE - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_1310061_2 335543.Sfum_1664 1.93e-81 249.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42RQX@68525|delta/epsilon subdivisions,2WNM1@28221|Deltaproteobacteria 28221|Deltaproteobacteria K response regulator - - - - - - - - - - - - GerE,Response_reg k59_1310061_3 580332.Slit_1820 2.12e-51 183.0 COG3283@1|root,COG4191@1|root,COG4585@1|root,COG3283@2|Bacteria,COG4191@2|Bacteria,COG4585@2|Bacteria,1PM1X@1224|Proteobacteria,2W8ZV@28216|Betaproteobacteria,44WJK@713636|Nitrosomonadales 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - HisKA_3 k59_578960_1 521674.Plim_2000 1.42e-54 184.0 COG1996@1|root,COG1996@2|Bacteria,2J54C@203682|Planctomycetes 203682|Planctomycetes K Psort location Cytoplasmic, score - - - - - - - - - - - - - k59_788916_1 290397.Adeh_0430 9.2e-68 217.0 COG1801@1|root,COG1801@2|Bacteria,1N4QE@1224|Proteobacteria,42PDW@68525|delta/epsilon subdivisions,2WK6H@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 k59_422311_1 1254432.SCE1572_04370 7.93e-150 444.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42NDG@68525|delta/epsilon subdivisions,2WKYU@28221|Deltaproteobacteria,2YTWT@29|Myxococcales 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_265639_1 1137799.GZ78_14485 9.65e-47 158.0 COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,1RXYF@1236|Gammaproteobacteria,1XHWD@135619|Oceanospirillales 135619|Oceanospirillales L HTH-like domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_474279_1 1499680.CCFE01000023_gene2396 5.03e-11 64.3 COG2199@1|root,COG2199@2|Bacteria,1VATI@1239|Firmicutes,4HIV8@91061|Bacilli,1ZI6H@1386|Bacillus 91061|Bacilli T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_474279_2 491915.Aflv_0247 9.4e-19 86.7 COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,4HA1D@91061|Bacilli,21V85@150247|Anoxybacillus 91061|Bacilli L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_578975_1 1049564.TevJSym_au00600 9.51e-85 254.0 COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,1RPT7@1236|Gammaproteobacteria,1J6R2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S SNARE associated Golgi protein Z012_09465 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - SNARE_assoc k59_370108_1 589865.DaAHT2_1897 7.76e-08 52.8 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,42N8B@68525|delta/epsilon subdivisions,2WJ6I@28221|Deltaproteobacteria,2MIR3@213118|Desulfobacterales 28221|Deltaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_370108_2 1121403.AUCV01000077_gene4330 1.09e-54 185.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2WIK7@28221|Deltaproteobacteria,2MIHR@213118|Desulfobacterales 28221|Deltaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1259048_1 1122603.ATVI01000005_gene3798 4.83e-59 191.0 COG3555@1|root,COG3555@2|Bacteria,1MW3M@1224|Proteobacteria,1RN80@1236|Gammaproteobacteria,1X3KN@135614|Xanthomonadales 135614|Xanthomonadales O aspartyl asparaginyl beta-hydroxylase aspH - - ko:K12979 - - - - ko00000,ko01000,ko01005 - - - Asp_Arg_Hydrox k59_1414614_2 1242864.D187_002482 9.81e-27 107.0 COG0500@1|root,COG2226@2|Bacteria,1RC36@1224|Proteobacteria,42UDA@68525|delta/epsilon subdivisions,2WQHW@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_31 k59_213326_1 1177154.Y5S_01713 2.67e-104 338.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,1XI5R@135619|Oceanospirillales 135619|Oceanospirillales S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16 k59_474292_2 469381.Dpep_0658 2.21e-19 89.4 COG0841@1|root,COG0841@2|Bacteria,3TA4E@508458|Synergistetes 508458|Synergistetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1415412_1 1348657.M622_05065 1.45e-48 165.0 COG3381@1|root,COG3381@2|Bacteria,1RAXF@1224|Proteobacteria,2VY6I@28216|Betaproteobacteria,2KXH2@206389|Rhodocyclales 206389|Rhodocyclales S Nitrate reductase delta subunit - - - - - - - - - - - - Nitrate_red_del k59_997236_1 334545.CCMG01000027_gene1621 5.11e-14 72.4 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2UFRX@28211|Alphaproteobacteria,47FMT@766|Rickettsiales 766|Rickettsiales O Hsp20/alpha crystallin family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_997236_2 234267.Acid_1043 1.18e-18 84.0 COG1210@1|root,COG1210@2|Bacteria,3Y39W@57723|Acidobacteria 57723|Acidobacteria M PFAM Nucleotidyl transferase - - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_690038_1 876044.IMCC3088_643 1.03e-34 134.0 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,1SKWH@1236|Gammaproteobacteria 1236|Gammaproteobacteria E FAD binding domain - - - - - - - - - - - - DAO k59_270437_1 448385.sce7577 3.61e-94 290.0 COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42N75@68525|delta/epsilon subdivisions,2WKJY@28221|Deltaproteobacteria,2Z2YT@29|Myxococcales 28221|Deltaproteobacteria S Calcineurin-like phosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos k59_270437_2 37919.EP51_05895 2.63e-19 90.9 COG1024@1|root,COG1024@2|Bacteria,2GN3P@201174|Actinobacteria,4FVWI@85025|Nocardiaceae 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1419581_1 395965.Msil_1011 3.69e-28 114.0 COG1216@1|root,COG1216@2|Bacteria,1R554@1224|Proteobacteria,2U3P6@28211|Alphaproteobacteria,3N9XF@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Glycosyl transferase, family 2 MA20_08330 - - - - - - - - - - - Glyco_tranf_2_3 k59_1265199_1 223926.28808040 2.47e-19 82.0 COG5572@1|root,COG5572@2|Bacteria,1PZ3H@1224|Proteobacteria,1SG80@1236|Gammaproteobacteria,1XYG7@135623|Vibrionales 135623|Vibrionales S Integral membrane protein - - - - - - - - - - - - DUF2282 k59_638458_1 34007.IT40_08890 1.35e-25 105.0 COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,2TQTX@28211|Alphaproteobacteria,2PYJ3@265|Paracoccus 28211|Alphaproteobacteria G Inositol monophosphatase family - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_740227_1 1122603.ATVI01000009_gene2612 1.57e-27 102.0 COG0724@1|root,COG0724@2|Bacteria 2|Bacteria K RNA recognition motif - - - - - - - - - - - - RRM_1 k59_740227_2 1197706.AKKK01000006_gene1207 1.88e-29 105.0 COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria 201174|Actinobacteria K Cold shock protein - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_740227_3 420324.KI912080_gene8209 1.43e-19 83.6 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2U1C5@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_4396_1 483219.LILAB_27650 3.49e-49 167.0 COG2374@1|root,COG2374@2|Bacteria,1RA34@1224|Proteobacteria,42XZM@68525|delta/epsilon subdivisions,2WT9C@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function (DUF3616) - - - - - - - - - - - - DUF3616 k59_1575673_1 395493.BegalDRAFT_2506 1.76e-98 298.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,4609F@72273|Thiotrichales 72273|Thiotrichales G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_479501_1 547559.Nmag_0816 2.27e-35 130.0 COG1250@1|root,arCOG00250@2157|Archaea,2XTMV@28890|Euryarchaeota,23RX3@183963|Halobacteria 183963|Halobacteria I 3-hydroxyacyl-CoA dehydrogenase hbd - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k59_1213100_1 471852.Tcur_2580 2.93e-149 438.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1314638_1 1035195.HMPREF9997_00388 8.19e-06 54.7 COG1169@1|root,COG1169@2|Bacteria,2GKE8@201174|Actinobacteria,22M2H@1653|Corynebacteriaceae 201174|Actinobacteria HQ Isochorismate synthase entC - 5.4.4.2 ko:K02361,ko:K02552 ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 M00116 R01717 RC00588 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv3215 Chorismate_bind k59_690055_1 379066.GAU_3104 8.66e-10 63.5 COG1196@1|root,COG1196@2|Bacteria,1ZU8V@142182|Gemmatimonadetes 142182|Gemmatimonadetes D nuclear chromosome segregation - - - - - - - - - - - - - k59_1157958_1 614083.AWQR01000037_gene3453 1.27e-44 156.0 COG0657@1|root,COG0657@2|Bacteria,1NA4A@1224|Proteobacteria,2VMES@28216|Betaproteobacteria,4AFPK@80864|Comamonadaceae 28216|Betaproteobacteria I Carboxylesterase family - - - - - - - - - - - - Abhydrolase_3,COesterase k59_1367307_1 1229909.NSED_01585 2.01e-56 185.0 COG2132@1|root,arCOG03914@2157|Archaea,41S77@651137|Thaumarchaeota 651137|Thaumarchaeota Q PFAM Multicopper oxidase - - - - - - - - - - - - Cu-oxidase_2,Cu-oxidase_3 k59_4397_1 713586.KB900536_gene367 4.11e-80 253.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1WVXY@135613|Chromatiales 135613|Chromatiales J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_374963_2 595460.RRSWK_02859 9.93e-13 66.2 COG2096@1|root,COG2096@2|Bacteria,2IZZ0@203682|Planctomycetes 203682|Planctomycetes S PFAM Cobalamin adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_740238_1 1049564.TevJSym_al00350 9.37e-73 230.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,1JA17@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria OU Peptidase family S49 sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_638478_1 457429.ABJI02000808_gene6494 1.52e-27 114.0 COG2124@1|root,COG2124@2|Bacteria,2GNJI@201174|Actinobacteria 201174|Actinobacteria Q cytochrome P450 - - - - - - - - - - - - p450 k59_1628620_2 667632.KB890166_gene1376 1.57e-42 145.0 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2VR35@28216|Betaproteobacteria,1K70P@119060|Burkholderiaceae 28216|Betaproteobacteria S Yqey-like protein yqeY - - ko:K09117 - - - - ko00000 - - - YqeY k59_1628620_3 519989.ECTPHS_06527 8.75e-09 52.8 COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria 1224|Proteobacteria J Belongs to the bacterial ribosomal protein bS21 family rpsU GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 k59_1213119_1 572477.Alvin_3065 4.83e-44 153.0 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1WW5V@135613|Chromatiales 135613|Chromatiales E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_1157963_1 1304883.KI912532_gene2330 2.52e-07 52.4 COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,2VKXP@28216|Betaproteobacteria,2KVTT@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_1157963_2 768671.ThimaDRAFT_4172 1.19e-144 416.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,1T0C6@1236|Gammaproteobacteria,1WXH4@135613|Chromatiales 135613|Chromatiales C PFAM Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_583573_1 1283300.ATXB01000001_gene603 6.67e-75 230.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1XEX5@135618|Methylococcales 135618|Methylococcales J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_1265233_1 1120951.AUBG01000001_gene889 3.52e-65 209.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,4NMMP@976|Bacteroidetes,1I8A6@117743|Flavobacteriia 976|Bacteroidetes C Cytochrome C oxidase subunit II, periplasmic domain - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,Cytochrom_C k59_1213123_1 1472716.KBK24_0137140 1.28e-54 183.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VISA@28216|Betaproteobacteria,1K0ER@119060|Burkholderiaceae 28216|Betaproteobacteria C 4Fe-4S dicluster domain glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7,Fer4_8 k59_1213123_2 1366050.N234_17635 1.75e-09 58.2 COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2VHUQ@28216|Betaproteobacteria,1K1XC@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM FAD linked oxidase domain protein glcE - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 k59_1157964_1 113395.AXAI01000021_gene3514 1.25e-11 69.7 COG3485@1|root,COG3485@2|Bacteria,1MX7W@1224|Proteobacteria,2TT8T@28211|Alphaproteobacteria,3JRKQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Dioxygenase_C,Dioxygenase_N k59_1367323_1 1123489.AUAN01000002_gene847 9.33e-30 111.0 COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,4H3YZ@909932|Negativicutes 909932|Negativicutes J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_1367323_2 479434.Sthe_1736 2.83e-56 182.0 COG0528@1|root,COG0528@2|Bacteria,2G5RG@200795|Chloroflexi,27XHK@189775|Thermomicrobia 189775|Thermomicrobia F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_270473_2 1034347.CAHJ01000029_gene3653 2.33e-08 57.8 COG2604@1|root,COG2604@2|Bacteria,1VAVV@1239|Firmicutes,4IK1S@91061|Bacilli,1ZF2N@1386|Bacillus 91061|Bacilli S Protein of unknown function DUF115 - - - - - - - - - - - - MAF_flag10 k59_1000979_1 406552.NJ7G_3312 1.61e-21 99.0 COG0277@1|root,arCOG00340@2157|Archaea,2Y85H@28890|Euryarchaeota,24157@183963|Halobacteria 183963|Halobacteria C COG0277 FAD FMN-containing dehydrogenases - - - - - - - - - - - - BBE,FAD_binding_4 k59_795329_1 344747.PM8797T_10149 1.95e-116 360.0 COG1914@1|root,COG1914@2|Bacteria 2|Bacteria P metal ion transmembrane transporter activity - - - - - - - - - - - - - k59_218139_1 436229.JOEH01000013_gene5871 1.81e-161 472.0 COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria,2NF1H@228398|Streptacidiphilus 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain fadD19 GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009605,GO:0009607,GO:0009987,GO:0015645,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019752,GO:0030312,GO:0032787,GO:0042546,GO:0042579,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051087,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071554,GO:0071704,GO:0071766,GO:0071840,GO:0071944,GO:0075136,GO:1901576 6.2.1.42 ko:K00666,ko:K18688 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1213132_1 713586.KB900536_gene1018 3.19e-23 99.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria,1WXQI@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_8 k59_1213132_2 768671.ThimaDRAFT_2909 2.07e-96 286.0 COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,1RYZ2@1236|Gammaproteobacteria,1WW9H@135613|Chromatiales 135613|Chromatiales C PFAM Nitrate reductase gamma subunit - - - - - - - - - - - - Nitrate_red_gam k59_112972_1 1267533.KB906735_gene5098 2.42e-72 233.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,3Y2I9@57723|Acidobacteria,2JHNT@204432|Acidobacteriia 204432|Acidobacteriia F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_1367337_2 99598.Cal7507_2327 1.39e-05 48.5 COG2084@1|root,COG2084@2|Bacteria,1GFKR@1117|Cyanobacteria,1HMUH@1161|Nostocales 1117|Cyanobacteria I Domain of unknown function (DUF1932) - - - - - - - - - - - - DUF1932,NAD_binding_2 k59_163824_1 1047013.AQSP01000139_gene2392 5.76e-108 322.0 COG0372@1|root,COG0372@2|Bacteria,2NP9P@2323|unclassified Bacteria 2|Bacteria C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_1213148_2 330214.NIDE1108 3.23e-20 92.0 COG1193@1|root,COG1193@2|Bacteria,3J0Y0@40117|Nitrospirae 40117|Nitrospirae L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr k59_531359_1 1158146.KB907125_gene2335 1.08e-86 278.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales 135613|Chromatiales D DNA segregation ATPase FtsK SpoIIIE - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1628653_1 330214.NIDE1228 4.21e-84 258.0 COG2199@1|root,COG3706@2|Bacteria,3J188@40117|Nitrospirae 40117|Nitrospirae T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_1419650_1 566466.NOR53_3699 1.32e-27 112.0 COG1231@1|root,COG1231@2|Bacteria,1QXX6@1224|Proteobacteria,1T3IZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - - - - - - - - - - NAD_binding_8 k59_1419650_2 391595.RLO149_c022070 4.07e-06 52.4 COG0457@1|root,COG2197@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2197@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,2P34H@2433|Roseobacter 28211|Alphaproteobacteria K Adenylate cyclase - - - - - - - - - - - - GerE,Guanylate_cyc,TIR_2,TPR_16,TPR_8,Trans_reg_C k59_690095_1 1395571.TMS3_0108230 6.86e-07 52.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.1.54,1.2.1.99 ko:K09472,ko:K12254 ko00330,ko01100,map00330,map01100 M00136 R02549,R03177,R07417,R07418 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_690095_2 649638.Trad_0121 5.95e-34 129.0 COG0160@1|root,COG0160@2|Bacteria,1WJ8V@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.19,2.6.1.22 ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1265268_1 648996.Theam_0894 6.87e-06 53.5 COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,2G3MD@200783|Aquificae 200783|Aquificae J tRNA nucleotidyltransferase poly(A) polymerase - - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd k59_845234_1 1173023.KE650771_gene1232 0.000387 43.9 COG2227@1|root,COG2227@2|Bacteria,1G3TD@1117|Cyanobacteria,1JJVY@1189|Stigonemataceae 1117|Cyanobacteria H Protein of unknown function (DUF1698) - - - - - - - - - - - - Methyltransf_25 k59_845234_2 754477.Q7C_1844 7.81e-45 151.0 2AG4U@1|root,3169G@2|Bacteria,1P980@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1419960_1 1220534.B655_2353 7.1e-08 53.5 arCOG07473@1|root,arCOG07473@2157|Archaea,2Y1CW@28890|Euryarchaeota,23PUR@183925|Methanobacteria 183925|Methanobacteria - - - - - - - - - - - - - - - k59_1419960_2 1229909.NSED_06965 1.12e-21 92.0 arCOG08777@1|root,arCOG10350@1|root,arCOG08777@2157|Archaea,arCOG10350@2157|Archaea 2157|Archaea C sister chromatid segregation - - - - - - - - - - - - - k59_375276_1 1304883.KI912532_gene1917 1.17e-87 271.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2VJ7Z@28216|Betaproteobacteria,2KUUD@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_1265573_1 215803.DB30_5121 7.58e-80 250.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,42YFS@68525|delta/epsilon subdivisions,2WUBM@28221|Deltaproteobacteria,2YU6D@29|Myxococcales 28221|Deltaproteobacteria C Iron-containing alcohol dehydrogenase - - - - - - - - - - - - Fe-ADH k59_323495_1 264198.Reut_A0313 8.26e-10 61.6 COG5488@1|root,COG5488@2|Bacteria,1N5Z9@1224|Proteobacteria,2VU1W@28216|Betaproteobacteria,1K6XS@119060|Burkholderiaceae 28216|Betaproteobacteria S Integral membrane protein (DUF2244) - - - - - - - - - - - - DUF2244 k59_323495_2 751994.AGIG01000027_gene1392 6.36e-24 100.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1J5CG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_270740_2 1082705.JIBP01000017_gene790 1.67e-18 84.3 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1106614_1 626887.J057_14585 2.62e-26 110.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,4663F@72275|Alteromonadaceae 1236|Gammaproteobacteria S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034203,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576 - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - iECO103_1326.ECO103_1114 MVIN k59_1106614_2 675816.VIA_000354 5.36e-18 82.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1XTHQ@135623|Vibrionales 135623|Vibrionales H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_1628937_1 713586.KB900536_gene1992 9.42e-51 171.0 COG1352@1|root,COG1352@2|Bacteria,1RDBE@1224|Proteobacteria 1224|Proteobacteria NT Methyltransferase, chemotaxis proteins - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_1575981_1 944480.ATUV01000001_gene924 1.54e-53 173.0 COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,42RVP@68525|delta/epsilon subdivisions,2WNCX@28221|Deltaproteobacteria,2M6H3@213113|Desulfurellales 28221|Deltaproteobacteria S Appr-1'-p processing enzyme ymdB - - - - - - - - - - - Macro k59_1265580_1 1121937.AUHJ01000013_gene822 6.15e-119 352.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,4642P@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG1194 A G-specific DNA glycosylase mutY GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_1265580_2 396595.TK90_2485 1.13e-43 143.0 COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,1S964@1236|Gammaproteobacteria,1WYU9@135613|Chromatiales 135613|Chromatiales CO Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - - - - - - - - - - Iron_traffic k59_845253_1 1214065.BAGV01000052_gene1795 1.9e-58 190.0 COG0494@1|root,COG0494@2|Bacteria,1RDMW@1224|Proteobacteria,1RPZV@1236|Gammaproteobacteria,28365@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria L NUDIX domain nudF GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019144,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0047631,GO:0050896 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - iECP_1309.ECP_3126 NUDIX k59_1001286_1 330214.NIDE3077 2.36e-130 389.0 COG0556@1|root,COG0556@2|Bacteria,3J0FS@40117|Nitrospirae 40117|Nitrospirae L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1106627_1 404589.Anae109_3070 1.56e-98 317.0 COG0296@1|root,COG3281@1|root,COG0296@2|Bacteria,COG3281@2|Bacteria,1QTVN@1224|Proteobacteria,42NYT@68525|delta/epsilon subdivisions,2WIM3@28221|Deltaproteobacteria,2Z34A@29|Myxococcales 28221|Deltaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_1054309_1 138119.DSY2007 1.03e-29 119.0 COG0837@1|root,COG0837@2|Bacteria,1VT6V@1239|Firmicutes,24YCM@186801|Clostridia,264CG@186807|Peptococcaceae 186801|Clostridia F Belongs to the bacterial glucokinase family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase k59_1367607_2 204669.Acid345_3356 1.46e-10 64.7 COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria,2JIG9@204432|Acidobacteriia 204432|Acidobacteriia T response regulator, receiver - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1575997_1 1348657.M622_05010 2.48e-34 135.0 COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,2WGS4@28216|Betaproteobacteria,2KU8N@206389|Rhodocyclales 206389|Rhodocyclales C Molydopterin dinucleotide binding domain - - 1.17.99.2 ko:K10700,ko:K17050 ko00642,ko01100,ko01120,ko01220,map00642,map01100,map01120,map01220 - R05745 RC00275 ko00000,ko00001,ko01000,ko02000 5.A.3.8,5.A.3.9 - - Molybdopterin,Molydop_binding k59_1158179_1 867845.KI911784_gene1375 2.05e-91 282.0 COG2133@1|root,COG2133@2|Bacteria,2G62S@200795|Chloroflexi,375V8@32061|Chloroflexia 32061|Chloroflexia G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH k59_583872_2 443144.GM21_1410 8.59e-16 77.4 COG1381@1|root,COG1381@2|Bacteria 2|Bacteria L Involved in DNA repair and RecF pathway recombination recO GO:0008150,GO:0009314,GO:0009628,GO:0050896 2.6.99.2 ko:K03474,ko:K03584 ko00750,ko01100,ko03440,map00750,map01100,map03440 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000,ko03400 - - - RecO_C,RecO_N k59_113244_1 436308.Nmar_1191 1.52e-98 305.0 COG1331@1|root,arCOG02007@2157|Archaea,41SHZ@651137|Thaumarchaeota 651137|Thaumarchaeota O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_1420008_1 502025.Hoch_5015 1.94e-59 196.0 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2WMXB@28221|Deltaproteobacteria,2YUZZ@29|Myxococcales 28221|Deltaproteobacteria L Uracil-DNA glycosylase - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1265612_1 458817.Shal_2683 1.08e-56 192.0 COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,1RR67@1236|Gammaproteobacteria,2Q98A@267890|Shewanellaceae 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1001307_1 1219045.BV98_001016 1.08e-92 279.0 COG1192@1|root,COG1192@2|Bacteria,1MWH3@1224|Proteobacteria,2U100@28211|Alphaproteobacteria,2K0JR@204457|Sphingomonadales 204457|Sphingomonadales D involved in chromosome partitioning - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_487850_1 1232428.CAVO010000128_gene643 1.09e-14 76.3 COG0309@1|root,COG0309@2|Bacteria,1TQP4@1239|Firmicutes,4H2UQ@909932|Negativicutes 909932|Negativicutes O hydrogenase expression formation protein HypE hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_487850_2 1370125.AUWT01000052_gene4806 1.3e-06 50.8 COG1024@1|root,COG1024@2|Bacteria,2GJ7Z@201174|Actinobacteria,234IG@1762|Mycobacteriaceae 201174|Actinobacteria I enoyl-CoA hydratase isomerase family - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_1273460_1 1445613.JALM01000148_gene4458 1.69e-41 146.0 COG1024@1|root,COG1024@2|Bacteria,2GJY4@201174|Actinobacteria,4E65T@85010|Pseudonocardiales 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_1273460_2 1219035.NT2_05_04580 4.02e-57 187.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria,2K3PM@204457|Sphingomonadales 204457|Sphingomonadales I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_276807_1 1123279.ATUS01000001_gene805 2.04e-96 300.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1S1M2@1236|Gammaproteobacteria,1J5J5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.12 ko:K14448 ko00630,ko01120,ko01200,map00630,map01120,map01200 M00373 R09293 RC02483 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1481432_1 1906.SFRA_13690 2.39e-20 98.6 COG2303@1|root,COG2303@2|Bacteria,2GNHC@201174|Actinobacteria 201174|Actinobacteria E glucose-methanol-choline oxidoreductase - - 1.1.1.400 ko:K20927,ko:K21166 ko01059,ko01130,map01059,map01130 M00824 - - ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_537371_2 1434325.AZQN01000008_gene2903 1.39e-21 98.2 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,47Y7Y@768503|Cytophagia 976|Bacteroidetes H PFAM TonB-dependent Receptor Plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1112534_2 765913.ThidrDRAFT_1434 1.06e-53 176.0 COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,1RMHS@1236|Gammaproteobacteria,1WY1C@135613|Chromatiales 135613|Chromatiales F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_1525135_1 936455.KI421499_gene2556 1.49e-14 72.8 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,3JTF6@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1525564_1 1122134.KB893650_gene373 6.7e-139 408.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1XHSI@135619|Oceanospirillales 135619|Oceanospirillales P Trk system potassium uptake protein trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1525564_2 637390.AFOH01000108_gene848 2.99e-09 57.0 COG0500@1|root,COG0500@2|Bacteria,1QU9M@1224|Proteobacteria,1T23F@1236|Gammaproteobacteria,2ND1G@225057|Acidithiobacillales 225057|Acidithiobacillales Q Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_25 k59_851790_2 1192124.LIG30_3617 6.48e-21 94.4 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2VHJJ@28216|Betaproteobacteria,1K2ZR@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_955697_1 1459636.NTE_00763 2.35e-46 160.0 COG0596@1|root,arCOG07416@1|root,arCOG01648@2157|Archaea,arCOG07416@2157|Archaea,41SFU@651137|Thaumarchaeota 2157|Archaea S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4,Abhydrolase_6 k59_170604_1 1499967.BAYZ01000136_gene58 4.83e-128 380.0 COG1003@1|root,COG1003@2|Bacteria,2NNSG@2323|unclassified Bacteria 2|Bacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPB - 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - Aminotran_5,GDC-P k59_330067_1 1379270.AUXF01000006_gene73 3.82e-19 83.6 COG0669@1|root,COG0669@2|Bacteria,1ZTTQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_330067_2 658187.LDG_8101 2.82e-48 167.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1JCDH@118969|Legionellales 118969|Legionellales H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine dfp - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_277548_1 998088.B565_2651 3.71e-40 153.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1Y3FT@135624|Aeromonadales 135624|Aeromonadales C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_1061168_2 316067.Geob_2164 1.37e-23 102.0 COG0745@1|root,COG0745@2|Bacteria,1NV0N@1224|Proteobacteria,42ZH3@68525|delta/epsilon subdivisions,2WUW0@28221|Deltaproteobacteria,43UQG@69541|Desulfuromonadales 28221|Deltaproteobacteria T zinc-ribbon domain - - - - - - - - - - - - Response_reg,zinc_ribbon_4 k59_1482260_1 429009.Adeg_0146 1.59e-46 164.0 COG0611@1|root,COG0611@2|Bacteria,1V0SM@1239|Firmicutes,24J04@186801|Clostridia,42G96@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_224963_1 67257.JODR01000014_gene5749 2.14e-15 80.5 COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria 201174|Actinobacteria IQ Peptidase S15 - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_1636379_1 1218103.CIN01S_13_01150 2.1e-27 111.0 COG2454@1|root,COG2454@2|Bacteria,4NN3Y@976|Bacteroidetes,1I1SF@117743|Flavobacteriia,3ZPNK@59732|Chryseobacterium 976|Bacteroidetes S Protein of unknown function (DUF434) - - - - - - - - - - - - DUF434 k59_1428585_1 317025.Tcr_2136 1.45e-87 268.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,4602Z@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_1320084_1 555079.Toce_1004 6.02e-25 110.0 COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,42FNE@68295|Thermoanaerobacterales 186801|Clostridia V PFAM multi antimicrobial extrusion protein MatE - - - - - - - - - - - - MatE k59_647543_1 935261.JAGL01000019_gene595 4.48e-10 64.3 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,43GY1@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_1636390_1 340.xcc-b100_3432 3.54e-60 201.0 COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,1RRMM@1236|Gammaproteobacteria,1X2YX@135614|Xanthomonadales 135614|Xanthomonadales E phospho-2-dehydro-3-deoxyheptonate aldolase dhs1 - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_2 k59_1220111_2 391625.PPSIR1_12483 4.82e-10 63.2 COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,42NTB@68525|delta/epsilon subdivisions,2WKNX@28221|Deltaproteobacteria 28221|Deltaproteobacteria S conserved protein UCP033563 - - - - - - - - - - - - DUF1015 k59_224976_1 1297865.APJD01000068_gene5775 5.72e-70 222.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,3JS1E@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L leucine-zipper of insertion element IS481 - - 2.7.7.49 ko:K00986,ko:K07497 - - - - ko00000,ko01000 - - - HTH_32,rve k59_434070_2 1380394.JADL01000001_gene2045 6.58e-51 171.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2TUWG@28211|Alphaproteobacteria,2JQ92@204441|Rhodospirillales 204441|Rhodospirillales EP N-terminal TM domain of oligopeptide transport permease C - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_538010_1 309801.trd_1276 4.79e-98 306.0 COG1154@1|root,COG1154@2|Bacteria,2G68R@200795|Chloroflexi,27XH0@189775|Thermomicrobia 189775|Thermomicrobia F Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_277573_1 1123355.JHYO01000036_gene619 2.13e-70 224.0 COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TRQ7@28211|Alphaproteobacteria,370IF@31993|Methylocystaceae 28211|Alphaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_224982_1 102129.Lepto7375DRAFT_2686 3.32e-59 199.0 COG1819@1|root,COG1819@2|Bacteria,1G036@1117|Cyanobacteria,1H8RN@1150|Oscillatoriales 1117|Cyanobacteria CG UDP-glucoronosyl and UDP-glucosyl transferase - - 2.4.1.173 ko:K05841 - - - - ko00000,ko01000,ko01003 - GT1 - Glyco_transf_28,UDPGT k59_955733_2 204669.Acid345_1270 1.14e-97 303.0 COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia 204432|Acidobacteriia Q Flavin containing amine oxidoreductase - - - - - - - - - - - - NAD_binding_8 k59_1582652_1 1242864.D187_008933 4.92e-26 109.0 COG3391@1|root,COG3391@2|Bacteria,1R7E0@1224|Proteobacteria,42Z2U@68525|delta/epsilon subdivisions,2WTYD@28221|Deltaproteobacteria,2YX64@29|Myxococcales 28221|Deltaproteobacteria S Cytochrome D1 heme domain - - - - - - - - - - - - Cytochrom_D1 k59_1113200_1 237368.SCABRO_02164 3.32e-10 63.5 COG0475@1|root,COG0475@2|Bacteria,2IZ8F@203682|Planctomycetes 203682|Planctomycetes P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_1113200_2 1121406.JAEX01000006_gene2160 1.11e-110 325.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,42M2J@68525|delta/epsilon subdivisions,2WJMH@28221|Deltaproteobacteria,2M84J@213115|Desulfovibrionales 28221|Deltaproteobacteria C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein sdhB - 1.3.5.1,1.3.5.4 ko:K00240,ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_10,Fer4_8 k59_1113200_3 880072.Desac_0860 2.94e-17 83.6 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2WJXY@28221|Deltaproteobacteria,2MQTE@213462|Syntrophobacterales 28221|Deltaproteobacteria C TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein sdhA - 1.3.5.1,1.3.5.4 ko:K00239,ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_121082_1 1216007.AOPM01000057_gene1850 4.06e-30 115.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,2PZWZ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Belongs to the ompA family pal GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032153,GO:0044425,GO:0044462,GO:0044464,GO:0051301,GO:0071944,GO:0098552 - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_1428629_1 387631.Asulf_01859 2.57e-72 227.0 COG4177@1|root,arCOG01274@2157|Archaea,2XW08@28890|Euryarchaeota,2463K@183980|Archaeoglobi 183980|Archaeoglobi E Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_72900_1 1244869.H261_12231 3.04e-89 282.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2JQSU@204441|Rhodospirillales 204441|Rhodospirillales EQ Hydantoinase/oxoprolinase - - - - - - - - - - - - Hydant_A_N,Hydantoinase_A k59_1482313_1 1318628.MARLIPOL_06959 6.28e-09 65.1 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,4658X@72275|Alteromonadaceae 1236|Gammaproteobacteria S exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - LolA_like,MMPL,Polyketide_cyc2 k59_1636426_1 1121939.L861_11035 2.37e-25 100.0 COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,1RNTN@1236|Gammaproteobacteria,1XICS@135619|Oceanospirillales 135619|Oceanospirillales Q ( 3 oxidation state) methyltransferase - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 k59_434102_2 765913.ThidrDRAFT_0917 1.38e-73 244.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales 135613|Chromatiales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_383282_1 1397666.RS24_00104 3.87e-48 174.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1220152_1 292415.Tbd_2220 2.93e-63 208.0 COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2VJR6@28216|Betaproteobacteria,1KS7Q@119069|Hydrogenophilales 119069|Hydrogenophilales C Pyridine nucleotide-disulphide oxidoreductase - - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1525610_1 1121019.AUMN01000001_gene622 4.17e-06 51.2 COG1335@1|root,COG1335@2|Bacteria,2IFQW@201174|Actinobacteria,1W8W0@1268|Micrococcaceae 201174|Actinobacteria Q Isochorismatase family pncA GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 - R01268 RC00100 ko00000,ko00001,ko01000 - - - Isochorismatase k59_1525610_2 1229172.JQFA01000002_gene4730 1.14e-06 46.6 COG2442@1|root,COG2442@2|Bacteria,1GA44@1117|Cyanobacteria,1HC3P@1150|Oscillatoriales 1117|Cyanobacteria S Protein of unknown function (DUF433) - - - - - - - - - - - - DUF433 k59_1636434_2 204669.Acid345_1270 2.32e-50 175.0 COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia 204432|Acidobacteriia Q Flavin containing amine oxidoreductase - - - - - - - - - - - - NAD_binding_8 k59_488757_1 1255043.TVNIR_1889 1.57e-98 293.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1WWZU@135613|Chromatiales 135613|Chromatiales M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_488757_2 633.DJ40_1619 2.2e-39 144.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,41DTM@629|Yersinia 1236|Gammaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_3323,iPC815.YPO3377 CTP_synth_N,GATase k59_170669_2 1493511.A0A0E3HRS2_9CAUD 1.73e-11 65.9 4QDAY@10239|Viruses,4QTPU@28883|Caudovirales,4QKG9@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1374096_1 765913.ThidrDRAFT_1734 2.23e-114 348.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1WW0N@135613|Chromatiales 135613|Chromatiales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1220160_1 347834.RHE_CH01221 7.95e-33 130.0 COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9US@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - BTAD,Guanylate_cyc k59_383310_1 1279017.AQYJ01000026_gene57 1.91e-55 195.0 COG1360@1|root,COG2885@1|root,COG1360@2|Bacteria,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,1T4AK@1236|Gammaproteobacteria,46ACU@72275|Alteromonadaceae 1236|Gammaproteobacteria M OmpA family - - - - - - - - - - - - DUF11,OmpA k59_72942_1 436308.Nmar_1597 2.62e-155 447.0 COG0043@1|root,arCOG01671@2157|Archaea,41SEQ@651137|Thaumarchaeota 651137|Thaumarchaeota H UbiD family decarboxylase - - - - - - - - - - - - UbiD k59_383315_1 1298880.AUEV01000018_gene270 4.73e-05 47.0 COG1470@1|root,COG1470@2|Bacteria,2I64T@201174|Actinobacteria 201174|Actinobacteria S CHRD domain - - - - - - - - - - - - CHRD k59_383315_2 2002.JOEQ01000001_gene4918 1.94e-06 49.7 COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4EH15@85012|Streptosporangiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1582708_1 1279015.KB908454_gene719 3.46e-42 147.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,1Y3SC@135624|Aeromonadales 135624|Aeromonadales J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1582708_2 631362.Thi970DRAFT_03481 1.42e-28 114.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1WVXY@135613|Chromatiales 135613|Chromatiales J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_647635_1 319003.Bra1253DRAFT_03244 8.28e-06 52.8 COG1262@1|root,COG2114@1|root,COG1262@2|Bacteria,COG2114@2|Bacteria,1NQ5K@1224|Proteobacteria,2U2VJ@28211|Alphaproteobacteria,3JTPW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase,Guanylate_cyc,TIR_2 k59_1169456_1 909663.KI867150_gene213 2.18e-59 207.0 COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria,2MRCI@213462|Syntrophobacterales 28221|Deltaproteobacteria M PFAM Tetratricopeptide repeat - - - - - - - - - - - - PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_1284878_1 118168.MC7420_6901 9.44e-15 68.2 COG0847@1|root,COG0847@2|Bacteria,1GH9W@1117|Cyanobacteria,1HGMV@1150|Oscillatoriales 1117|Cyanobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease - - - - - - - - - - - - - k59_337635_1 283942.IL0337 8.73e-71 225.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,2QFRT@267893|Idiomarinaceae 1236|Gammaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063,iJN746.PP_4889 Adenylsucc_synt k59_285336_2 243231.GSU3316 3.1e-29 112.0 COG0755@1|root,COG0755@2|Bacteria 2|Bacteria O cytochrome complex assembly - - - - - - - - - - - - Cytochrom_C_asm k59_176497_1 665952.HMPREF1015_01153 1.27e-11 68.6 COG3039@1|root,COG3039@2|Bacteria,1UZVA@1239|Firmicutes,4HHAJ@91061|Bacilli,1ZN8I@1386|Bacillus 91061|Bacilli L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_3 k59_1590523_1 653733.Selin_0436 2.85e-54 185.0 COG3014@1|root,COG3014@2|Bacteria 2|Bacteria S protein conserved in bacteria - - - ko:K09859 - - - - ko00000 - - - - k59_1068855_1 436308.Nmar_0726 3.09e-152 443.0 COG0553@1|root,arCOG00883@2157|Archaea,41T0G@651137|Thaumarchaeota 651137|Thaumarchaeota K SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_499045_1 2340.JV46_26700 7.56e-106 317.0 COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1JBG6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cysteine-rich domain dgcB - - ko:K21834 - - - - ko00000 - - - CCG,DUF3483,Fer4_8 k59_83126_1 1410620.SHLA_29c000690 5.77e-07 56.2 COG1011@1|root,COG1011@2|Bacteria,1N73G@1224|Proteobacteria,2TVJH@28211|Alphaproteobacteria,4BDZN@82115|Rhizobiaceae 28211|Alphaproteobacteria S Haloacid dehalogenase-like hydrolase - - - ko:K07025 - - - - ko00000 - - - HAD_2 k59_83126_2 411479.BACUNI_00066 1.3e-14 73.2 COG1621@1|root,COG4354@1|root,COG1621@2|Bacteria,COG4354@2|Bacteria,4NFQW@976|Bacteroidetes,2FQ1M@200643|Bacteroidia,4APRV@815|Bacteroidaceae 976|Bacteroidetes G Pfam:GBA2_N - - 3.2.1.45 ko:K17108 ko00511,ko00600,ko01100,map00511,map00600,map01100 - R01498 RC00059,RC00451 ko00000,ko00001,ko01000 - GH116 - DUF608,Glyco_hydr_116N k59_337643_1 330214.NIDE3255 2.09e-126 391.0 COG0243@1|root,COG0243@2|Bacteria 2|Bacteria C molybdopterin cofactor binding ddhA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4 ko:K00370,ko:K10700,ko:K16964,ko:K17050 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_1325859_1 1278309.KB907100_gene1784 1.01e-40 151.0 COG1215@1|root,COG1216@1|root,COG1215@2|Bacteria,COG1216@2|Bacteria,1MX5Z@1224|Proteobacteria,1RMDY@1236|Gammaproteobacteria,1XP1Z@135619|Oceanospirillales 135619|Oceanospirillales M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_83133_1 314345.SPV1_12290 4.57e-39 140.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria 1224|Proteobacteria BQ Including yeast histone deacetylase and acetoin utilization protein - - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl k59_83133_2 583355.Caka_2024 1.98e-11 62.4 2E4SV@1|root,32ZM7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - PGPGW k59_1492501_1 1123519.PSJM300_03315 4.53e-07 50.8 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1Z0PY@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050570,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_0056 PdxA k59_1492501_2 768671.ThimaDRAFT_3603 1.88e-52 171.0 COG1230@1|root,COG1230@2|Bacteria,1MUSS@1224|Proteobacteria,1RQ3M@1236|Gammaproteobacteria,1X266@135613|Chromatiales 135613|Chromatiales P Cation efflux family - - - - - - - - - - - - Cation_efflux k59_545395_1 261292.Nit79A3_1880 3.81e-24 101.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2VINP@28216|Betaproteobacteria,372PB@32003|Nitrosomonadales 28216|Betaproteobacteria E Belongs to the aspartokinase family lysC GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_598192_1 1232410.KI421421_gene3668 4.42e-113 347.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2WIX5@28221|Deltaproteobacteria,43S0M@69541|Desulfuromonadales 28221|Deltaproteobacteria F Transketolase, thiamine diphosphate binding domain dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_83141_1 555778.Hneap_1043 8.47e-58 194.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1WX0A@135613|Chromatiales 135613|Chromatiales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_391378_1 330214.NIDE3743 2.67e-71 232.0 COG1132@1|root,COG1132@2|Bacteria,3J0X8@40117|Nitrospirae 40117|Nitrospirae V Evidence 2a Function of homologous gene experimentally demonstrated in an other organism - - - ko:K06147,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1492507_1 1379270.AUXF01000002_gene1475 3.32e-08 57.8 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1ZTAG@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF_2,HATPase_c,HisKA k59_1492507_2 96561.Dole_1777 6.73e-42 154.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MPSH@213118|Desulfobacterales 28221|Deltaproteobacteria T Sigma-54 interaction domain - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1531332_1 68570.DC74_1107 9.01e-90 271.0 COG1024@1|root,COG1024@2|Bacteria,2GJY4@201174|Actinobacteria 201174|Actinobacteria I Enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 k59_1229353_2 330214.NIDE2748 1.65e-31 112.0 COG0425@1|root,COG0425@2|Bacteria,3J1DD@40117|Nitrospirae 40117|Nitrospirae O Sulfurtransferase TusA - - - - - - - - - - - - TusA k59_814946_1 101510.RHA1_ro02599 6.64e-06 47.0 COG1028@1|root,COG1028@2|Bacteria,2GKI2@201174|Actinobacteria,4FUVW@85025|Nocardiaceae 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short,adh_short_C2 k59_814946_3 323848.Nmul_A1295 6.25e-41 144.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria,37275@32003|Nitrosomonadales 28216|Betaproteobacteria L HTH-like domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_499071_1 1380391.JIAS01000017_gene642 1.22e-59 197.0 COG3608@1|root,COG3608@2|Bacteria,1N396@1224|Proteobacteria,2U17F@28211|Alphaproteobacteria,2JQE3@204441|Rhodospirillales 204441|Rhodospirillales S Succinylglutamate desuccinylase / Aspartoacylase family - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_1381205_1 1284708.HMPREF1634_02365 2.11e-13 71.2 COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,247Y5@186801|Clostridia,3WCSV@538999|Clostridiales incertae sedis 186801|Clostridia H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS thiI - 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07461 - ko00000,ko00001,ko01000,ko03016 - - - THUMP,ThiI k59_657879_1 1121441.AUCX01000004_gene3089 8.81e-37 134.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,42N5Q@68525|delta/epsilon subdivisions,2WJ8J@28221|Deltaproteobacteria,2M7ZZ@213115|Desulfovibrionales 28221|Deltaproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_657879_3 1232410.KI421421_gene3858 6.55e-16 80.9 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,43TBV@69541|Desulfuromonadales 28221|Deltaproteobacteria M PASTA domain ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase k59_1120771_1 589865.DaAHT2_1495 1.36e-136 409.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MHQQ@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the peptidase S1C family degP-2 - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1284920_1 436308.Nmar_0033 6.95e-29 106.0 COG3432@1|root,arCOG01055@2157|Archaea,41T3P@651137|Thaumarchaeota 651137|Thaumarchaeota K Winged helix-turn-helix - - - - - - - - - - - - HTH_45 k59_443036_1 1469245.JFBG01000016_gene967 3.25e-167 481.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1WWX1@135613|Chromatiales 135613|Chromatiales C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_704607_1 1121875.KB907546_gene2238 1.09e-98 296.0 COG1409@1|root,COG1409@2|Bacteria,4NFAP@976|Bacteroidetes,1I2DE@117743|Flavobacteriia 976|Bacteroidetes S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos,PA14 k59_545409_1 1123514.KB905899_gene1288 5.59e-87 270.0 COG0531@1|root,COG0531@2|Bacteria,1QXK2@1224|Proteobacteria,1T9HN@1236|Gammaproteobacteria,461QT@72273|Thiotrichales 72273|Thiotrichales E PFAM Amino acid - - - - - - - - - - - - AA_permease_2 k59_912166_1 317013.NY99_09590 3.79e-81 251.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,1X3G9@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_1590568_1 326298.Suden_1920 1.76e-14 74.3 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2YMXT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_1590568_2 1492738.FEM21_12610 2.92e-15 76.6 COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,4NFT6@976|Bacteroidetes,1I14A@117743|Flavobacteriia,2NV3V@237|Flavobacterium 976|Bacteroidetes CE FAD dependent oxidoreductase - - - - - - - - - - - - DAO,Rieske k59_859745_1 1292373.H640_02023 1.34e-05 52.8 COG0038@1|root,COG0038@2|Bacteria 2|Bacteria P chloride channel clcA_2 - - ko:K03281 - - - - ko00000 2.A.49 - - Voltage_CLC k59_1645727_1 472759.Nhal_3354 2.04e-73 233.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1WXMI@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_3,HlyD_D23 k59_598224_1 570268.ANBB01000033_gene2185 2.67e-47 156.0 COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,4EIMC@85012|Streptosporangiales 201174|Actinobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_391401_1 686340.Metal_1796 7.8e-53 176.0 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1XDS5@135618|Methylococcales 135618|Methylococcales E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_963236_1 436308.Nmar_0437 2.7e-93 277.0 COG1948@1|root,arCOG04206@2157|Archaea,41SIH@651137|Thaumarchaeota 651137|Thaumarchaeota L ERCC4 domain - - - ko:K10848 ko03420,ko03460,map03420,map03460 - - - ko00000,ko00001,ko01000,ko03032,ko03400 - - - ERCC4,HHH_5 k59_1531356_1 330214.NIDE4112 1.04e-38 140.0 COG3635@1|root,COG3635@2|Bacteria,3J0YA@40117|Nitrospirae 40117|Nitrospirae G Metalloenzyme superfamily - - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase k59_1531356_2 330214.NIDE4113 2.53e-19 86.3 COG0498@1|root,COG0498@2|Bacteria,3J0FI@40117|Nitrospirae 40117|Nitrospirae E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine thrC2 - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_814988_1 1207063.P24_16040 3.15e-84 267.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,2JQDH@204441|Rhodospirillales 204441|Rhodospirillales S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_1381233_1 1123296.JQKE01000010_gene100 1.58e-24 104.0 COG0204@1|root,COG0204@2|Bacteria,1N2DG@1224|Proteobacteria,2VRHK@28216|Betaproteobacteria,2KTZA@206351|Neisseriales 206351|Neisseriales I Phosphate acyltransferases - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_912186_1 1432056.X781_19530 3.93e-47 164.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1Y7IV@135625|Pasteurellales 135625|Pasteurellales S UPF0701 protein Z012_09350 - - - - - - - - - - - DUF1732,YicC_N k59_912186_2 59196.RICGR_0233 1.97e-17 78.6 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1JCFN@118969|Legionellales 118969|Legionellales F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_657928_1 1191523.MROS_0219 1.21e-56 196.0 COG0480@1|root,COG0480@2|Bacteria 2|Bacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_499135_1 998674.ATTE01000001_gene1291 1.4e-15 75.9 COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,1RQ47@1236|Gammaproteobacteria,462AG@72273|Thiotrichales 72273|Thiotrichales P Predicted Permease Membrane Region - - - - - - - - - - - - Asp-Al_Ex,TrkA_C k59_499135_2 196367.JNFG01000023_gene8188 1.39e-107 323.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VMYW@28216|Betaproteobacteria,1K1RG@119060|Burkholderiaceae 28216|Betaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_232449_1 73044.JNXP01000009_gene2705 6.67e-15 74.3 COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria 201174|Actinobacteria EP Belongs to the ABC transporter superfamily dppD - - ko:K02031,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_1493621_1 1268635.Loa_02179 2.58e-40 146.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria,1JCKR@118969|Legionellales 118969|Legionellales E Amino acid permease - - - - - - - - - - - - AA_permease_2 k59_338515_1 977880.RALTA_A0414 2.17e-78 250.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VH80@28216|Betaproteobacteria,1K09P@119060|Burkholderiaceae 28216|Betaproteobacteria IQ amp-dependent synthetase and ligase - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_860622_1 426355.Mrad2831_5367 2.96e-66 220.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,1JSXI@119045|Methylobacteriaceae 28211|Alphaproteobacteria V TIGRFAM lipid A ABC exporter family, fused ATPase and inner membrane subunits msbA2 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1326583_1 326427.Cagg_1989 2.36e-76 239.0 COG0451@1|root,COG0451@2|Bacteria 2|Bacteria GM ADP-glyceromanno-heptose 6-epimerase activity - - 5.1.3.10,5.1.3.2 ko:K01784,ko:K12454 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984,R04266 RC00289,RC00528 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_1286107_1 1220535.IMCC14465_17250 1.71e-91 278.0 COG2159@1|root,COG2159@2|Bacteria,1R3TG@1224|Proteobacteria,2URNF@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1286107_2 1030157.AFMP01000031_gene3077 6.72e-08 52.8 COG1804@1|root,COG1804@2|Bacteria,1N7RG@1224|Proteobacteria,2TSMH@28211|Alphaproteobacteria,2K2QC@204457|Sphingomonadales 204457|Sphingomonadales C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_659065_1 47839.CCAU010000002_gene2771 1.51e-229 660.0 COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,232Y5@1762|Mycobacteriaceae 201174|Actinobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1069764_1 870187.Thini_2823 7.59e-82 254.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,4609F@72273|Thiotrichales 72273|Thiotrichales G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_1591482_1 1121272.KB903249_gene2267 5.19e-93 295.0 28IUR@1|root,2Z8TE@2|Bacteria,2I9P5@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1493664_1 745411.B3C1_05897 1.42e-59 204.0 COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1J4XH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU General secretion pathway protein D xpsD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_500227_1 1042375.AFPL01000058_gene1455 7.65e-38 142.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,46403@72275|Alteromonadaceae 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1381959_1 1079460.ATTQ01000001_gene5464 2.91e-287 802.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_913079_1 305700.B447_16377 5.88e-17 80.1 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,2KV81@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_1539205_1 521393.JH806632_gene762 1.87e-88 285.0 COG0370@1|root,COG0370@2|Bacteria,2GTV2@201174|Actinobacteria,4D44Z@85005|Actinomycetales 201174|Actinobacteria P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoA,FeoB_C,FeoB_N,Gate k59_868248_1 314278.NB231_09038 7.34e-88 272.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWT4@135613|Chromatiales 135613|Chromatiales U Ammonium transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_399421_1 573370.DMR_40750 3.99e-58 196.0 COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,42PMJ@68525|delta/epsilon subdivisions,2X5FZ@28221|Deltaproteobacteria,2MGQC@213115|Desulfovibrionales 28221|Deltaproteobacteria EGP Sugar (and other) transporter - - - ko:K03762 - - - - ko00000,ko02000 2.A.1.6.4 - - MFS_1,Sugar_tr k59_923436_1 436308.Nmar_1103 3.52e-119 355.0 COG0322@1|root,arCOG04753@2157|Archaea,41SX9@651137|Thaumarchaeota 651137|Thaumarchaeota L TIGRFAM excinuclease ABC, C subunit - - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,UVR,UvrC_HhH_N k59_1240469_1 2340.JV46_24120 8.28e-66 206.0 COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,1J56A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0625 Glutathione S-transferase sspA GO:0001000,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0008150,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0042594,GO:0043175,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03599 - - - - ko00000,ko02000,ko03021 1.A.12.3.1 - - GST_C,GST_N,GST_N_3 k59_1240471_1 398767.Glov_1650 1.65e-23 104.0 COG0392@1|root,COG0392@2|Bacteria,1N7DR@1224|Proteobacteria,42N4R@68525|delta/epsilon subdivisions,2WS5Z@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_1505012_1 436308.Nmar_0505 7.83e-37 125.0 COG1599@1|root,arCOG01510@2157|Archaea,41SV1@651137|Thaumarchaeota 651137|Thaumarchaeota L COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins - - - ko:K07466 ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460 M00288 - - ko00000,ko00001,ko00002,ko03000,ko03032,ko03400 - - - tRNA_anti-codon k59_95022_1 945713.IALB_0639 1.17e-69 235.0 COG0532@1|root,COG0532@2|Bacteria 2|Bacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N k59_606452_1 1132855.KB913035_gene1383 1.83e-51 182.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VMVP@28216|Betaproteobacteria,2KMF9@206350|Nitrosomonadales 206350|Nitrosomonadales G PQQ-like domain - - - - - - - - - - - - PQQ,PQQ_2 k59_868272_1 1236542.BALM01000031_gene1907 9.73e-37 141.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RQZD@1236|Gammaproteobacteria,2Q9S4@267890|Shewanellaceae 1236|Gammaproteobacteria T histidine kinase HAMP region domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,sCache_3_3 k59_141263_1 296591.Bpro_4790 4.15e-76 236.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2VKD3@28216|Betaproteobacteria,4AJ99@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF692) - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_972155_1 1487953.JMKF01000073_gene3678 3.02e-36 140.0 COG0659@1|root,COG0659@2|Bacteria,1G3AY@1117|Cyanobacteria,1H9Q2@1150|Oscillatoriales 1117|Cyanobacteria P Sulfate permease family - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp,cNMP_binding k59_1177841_1 187272.Mlg_1800 9.82e-112 353.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales 135613|Chromatiales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_763194_2 641143.HMPREF9331_00291 1.02e-18 91.3 COG0466@1|root,COG0466@2|Bacteria,4NE1G@976|Bacteroidetes,1HX2R@117743|Flavobacteriia,1EQ3Q@1016|Capnocytophaga 976|Bacteroidetes O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_923460_1 448385.sce5871 5.9e-86 283.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,2YX1T@29|Myxococcales 28221|Deltaproteobacteria H Methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_1448082_1 519989.ECTPHS_01919 6.62e-23 100.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1WWMP@135613|Chromatiales 135613|Chromatiales M PFAM peptidase - - - - - - - - - - - - Peptidase_M23 k59_1080016_1 639282.DEFDS_0046 1.16e-82 272.0 COG0653@1|root,COG0653@2|Bacteria,2GEMD@200930|Deferribacteres 200930|Deferribacteres U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_713638_2 1141136.K4F9L9_9CAUD 1.03e-25 102.0 4QAJN@10239|Viruses,4R0G1@35237|dsDNA viruses no RNA stage,4QQGC@28883|Caudovirales,4QJ56@10662|Myoviridae 10662|Myoviridae S exonuclease activity - - - - - - - - - - - - - k59_1658324_1 414684.RC1_0629 1.21e-50 172.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,2TS40@28211|Alphaproteobacteria,2JQW1@204441|Rhodospirillales 204441|Rhodospirillales S Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_16121_1 1380394.JADL01000003_gene5080 1.09e-42 152.0 COG0265@1|root,COG0265@2|Bacteria,1MURF@1224|Proteobacteria,2TUVW@28211|Alphaproteobacteria,2JRVV@204441|Rhodospirillales 204441|Rhodospirillales O Domain present in PSD-95, Dlg, and ZO-1/2. - - - - - - - - - - - - PDZ_2,Trypsin_2 k59_1240520_1 1158607.UAU_04996 2.53e-29 113.0 COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,4H9WF@91061|Bacilli,4B010@81852|Enterococcaceae 91061|Bacilli S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113 - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_1240520_2 395961.Cyan7425_4023 8.08e-33 122.0 COG1131@1|root,COG1131@2|Bacteria,1G11U@1117|Cyanobacteria,3KFZG@43988|Cyanothece 1117|Cyanobacteria V PFAM ABC transporter related - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_296376_1 396588.Tgr7_1515 9.29e-121 351.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,1RNH2@1236|Gammaproteobacteria,1WWM8@135613|Chromatiales 135613|Chromatiales IQ TIGRFAM acetoacetyl-CoA reductase - - 1.1.1.36 ko:K00023 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R01779,R01977 RC00103,RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short_C2 k59_296376_2 1249627.D779_3289 1.46e-60 197.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1WW4A@135613|Chromatiales 135613|Chromatiales I Belongs to the thiolase family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_141302_3 1168067.JAGP01000001_gene1890 6.44e-13 69.3 COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,1RYFC@1236|Gammaproteobacteria,460S7@72273|Thiotrichales 72273|Thiotrichales T HPP family - - - - - - - - - - - - HPP k59_827636_1 998674.ATTE01000001_gene1672 3.79e-88 267.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,4608I@72273|Thiotrichales 72273|Thiotrichales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_184431_1 94624.Bpet2320 2.58e-06 49.3 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2VJD1@28216|Betaproteobacteria,3T1ZX@506|Alcaligenaceae 28216|Betaproteobacteria E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_184431_2 270374.MELB17_20696 6.93e-34 125.0 COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,467FD@72275|Alteromonadaceae 1236|Gammaproteobacteria S integral membrane protein yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_184431_3 637389.Acaty_c2522 4.4e-18 82.8 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,2NC8P@225057|Acidithiobacillales 225057|Acidithiobacillales E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metXS - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_763229_1 1148.1653490 1.93e-70 221.0 COG3588@1|root,COG3588@2|Bacteria,1GIGU@1117|Cyanobacteria,1H6CK@1142|Synechocystis 1117|Cyanobacteria F Fructose-bisphosphate aldolase class-I - - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic k59_16447_2 1316936.K678_11126 2.3e-74 236.0 COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,2TV6U@28211|Alphaproteobacteria,2JQ9F@204441|Rhodospirillales 204441|Rhodospirillales I Lysophospholipase - - - - - - - - - - - - Hydrolase_4 k59_973083_1 83406.HDN1F_01670 2.54e-16 77.8 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,1RN81@1236|Gammaproteobacteria,1J8FK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG0183 Acetyl-CoA acetyltransferase - - - - - - - - - - - - Thiolase_C k59_973083_2 419947.MRA_3585 3.61e-62 204.0 COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,233JC@1762|Mycobacteriaceae 201174|Actinobacteria I Belongs to the thiolase family fadA5 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0042802,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_555421_1 1254432.SCE1572_18090 1.06e-35 137.0 COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria,43A4M@68525|delta/epsilon subdivisions,2WYKE@28221|Deltaproteobacteria,2Z0NN@29|Myxococcales 28221|Deltaproteobacteria E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_142116_2 391615.ABSJ01000017_gene1675 4.63e-29 114.0 COG0810@1|root,COG0810@2|Bacteria,1PEDH@1224|Proteobacteria,1RRNT@1236|Gammaproteobacteria,1J5VC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_16451_1 1537994.JQFW01000020_gene2003 3.05e-13 74.7 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,465DA@72275|Alteromonadaceae 1236|Gammaproteobacteria U Type II secretory pathway, component ExeA mshM - - ko:K12283 - - - - ko00000,ko02044 - - - AAA_22 k59_869171_1 1121104.AQXH01000003_gene345 5.54e-17 80.1 COG2905@1|root,COG2905@2|Bacteria,4NTDP@976|Bacteroidetes 976|Bacteroidetes T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_869171_2 574087.Acear_1529 3.55e-12 64.3 COG4031@1|root,COG4031@2|Bacteria,1VAEH@1239|Firmicutes,24PMB@186801|Clostridia,3WATG@53433|Halanaerobiales 186801|Clostridia S Predicted metal-binding protein (DUF2103) - - - - - - - - - - - - DUF2103 k59_973109_1 311424.DhcVS_981 3.34e-39 138.0 COG2065@1|root,COG2065@2|Bacteria,2G6WS@200795|Chloroflexi,34D9M@301297|Dehalococcoidia 301297|Dehalococcoidia F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant pyrR GO:0003674,GO:0003700,GO:0003824,GO:0004845,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0043094,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran k59_607253_1 1274374.CBLK010000055_gene38 3.54e-27 113.0 COG2909@1|root,COG2909@2|Bacteria,1UIMV@1239|Firmicutes,4HD7H@91061|Bacilli,26QDM@186822|Paenibacillaceae 91061|Bacilli K helix_turn_helix, Lux Regulon - - - ko:K03556 - - - - ko00000,ko03000 - - - GerE k59_96053_1 478741.JAFS01000002_gene348 9.5e-14 70.1 COG0535@1|root,COG0535@2|Bacteria,46V38@74201|Verrucomicrobia,37FZS@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia S Domain of unknown function (DUF3463) - - - - - - - - - - - - DUF3463,Radical_SAM k59_96053_2 1089546.AQUI01000002_gene2242 1.83e-70 231.0 COG1657@1|root,COG1657@2|Bacteria,2GM7H@201174|Actinobacteria,408CV@622450|Actinopolysporales 201174|Actinobacteria I Squalene-hopene cyclase C-terminal domain shc - 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 - R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 - - - SQHop_cyclase_C,SQHop_cyclase_N k59_607257_1 247490.KSU1_B0327 1.73e-35 137.0 COG0581@1|root,COG0581@2|Bacteria,2IZJV@203682|Planctomycetes 203682|Planctomycetes P phosphate ABC transporter - - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_714591_1 1209072.ALBT01000035_gene1387 9.32e-07 52.4 COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,1SCYD@1236|Gammaproteobacteria,1FHD2@10|Cellvibrio 1236|Gammaproteobacteria NU Domain of unknown function (DUF4845) - - - - - - - - - - - - DUF4845 k59_714591_2 243233.MCA1465 1.16e-16 78.6 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1XEDU@135618|Methylococcales 135618|Methylococcales U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_142139_1 1255043.TVNIR_3463 5.22e-28 107.0 COG4319@1|root,COG4319@2|Bacteria,1NEUY@1224|Proteobacteria,1S6AP@1236|Gammaproteobacteria,1WYK1@135613|Chromatiales 135613|Chromatiales S SnoaL-like domain - - - - - - - - - - - - SnoaL_3 k59_142139_2 1469245.JFBG01000060_gene2391 1.73e-29 116.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1WXVV@135613|Chromatiales 135613|Chromatiales J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_764097_1 488538.SAR116_1471 3.58e-93 282.0 COG0715@1|root,COG0715@2|Bacteria 2|Bacteria P thiamine-containing compound biosynthetic process - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_455241_1 1235794.C811_01936 3.27e-40 147.0 COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4CUGN@84998|Coriobacteriia 84998|Coriobacteriia J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_400274_2 1168065.DOK_15504 3.12e-07 56.2 COG1595@1|root,COG1595@2|Bacteria,1RI7C@1224|Proteobacteria,1S6D1@1236|Gammaproteobacteria,1J6CR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1081050_1 1121403.AUCV01000002_gene511 5.17e-79 242.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RCI@68525|delta/epsilon subdivisions,2WM55@28221|Deltaproteobacteria,2MPY6@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Electron transfer flavoprotein - - - ko:K03521 - - - - ko00000 - - - ETF k59_16461_1 436308.Nmar_0381 1.02e-53 176.0 COG0244@1|root,arCOG04288@2157|Archaea,41S9R@651137|Thaumarchaeota 651137|Thaumarchaeota J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rpl10 - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_16461_2 436308.Nmar_0382 2.03e-13 68.2 COG0081@1|root,arCOG04289@2157|Archaea,41SHF@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds directly to 23S rRNA. Probably involved in E site tRNA release rpl1 - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_1334827_1 42256.RradSPS_1520 1.71e-21 94.7 COG1385@1|root,COG1385@2|Bacteria,2GTKX@201174|Actinobacteria 201174|Actinobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit - - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_96074_1 396588.Tgr7_1436 5.14e-84 259.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,1WVWC@135613|Chromatiales 135613|Chromatiales K TIGRFAM RNA polymerase sigma factor RpoS rpoS - - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_185231_1 1499967.BAYZ01000115_gene2932 8.5e-74 244.0 COG0112@1|root,COG0404@1|root,COG0112@2|Bacteria,COG0404@2|Bacteria,2NP28@2323|unclassified Bacteria 2|Bacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism gcvT GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.1,2.1.2.10,2.2.1.8 ko:K00600,ko:K00605,ko:K18847 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R01221,R02300,R04125,R09099 RC00022,RC00069,RC00112,RC00183,RC01583,RC02834,RC02958 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C,SHMT k59_512941_1 330214.NIDE0360 3.19e-06 48.1 COG0706@1|root,COG0706@2|Bacteria,3J0GD@40117|Nitrospirae 40117|Nitrospirae U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_1599644_1 398767.Glov_1340 3.43e-94 308.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_242520_1 380703.AHA_1863 3.53e-16 77.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1Y3MS@135624|Aeromonadales 135624|Aeromonadales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_242520_2 1121937.AUHJ01000005_gene2262 6.44e-06 48.5 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,4647U@72275|Alteromonadaceae 1236|Gammaproteobacteria D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins ftsK GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_349576_1 330214.NIDE0971 2.56e-90 275.0 COG0674@1|root,COG0674@2|Bacteria,3J0WN@40117|Nitrospirae 40117|Nitrospirae C Pyruvate:ferredoxin oxidoreductase core domain II - - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_1390299_1 330214.NIDE3313 3.66e-100 323.0 COG2132@1|root,COG2132@2|Bacteria 2|Bacteria Q Multicopper oxidase - - 1.16.3.3,1.7.2.1 ko:K00368,ko:K07233,ko:K22349 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Copper-bind,Cu-oxidase_2,Cu-oxidase_3 k59_555486_1 880073.Calab_1902 4.61e-18 89.0 COG1033@1|root,COG1033@2|Bacteria,2NQ2I@2323|unclassified Bacteria 2|Bacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - LolA_like,MMPL,Polyketide_cyc2 k59_1540070_1 1288298.rosmuc_04023 9.61e-05 47.0 COG2010@1|root,COG2010@2|Bacteria,1RGXM@1224|Proteobacteria,2U95Y@28211|Alphaproteobacteria,46R5Z@74030|Roseovarius 28211|Alphaproteobacteria C COG2010 Cytochrome c, mono- and diheme variants cytC - - - - - - - - - - - Cytochrome_CBB3 k59_1081077_1 330214.NIDE1580 7.78e-92 291.0 COG1452@1|root,COG1452@2|Bacteria,3J0QI@40117|Nitrospirae 40117|Nitrospirae M involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA k59_973167_2 118005.AWNK01000003_gene2225 3.97e-28 106.0 COG2885@1|root,COG2885@2|Bacteria 2|Bacteria M chlorophyll binding pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_555508_1 521393.JH806634_gene1956 4.82e-07 56.6 COG1215@1|root,COG1215@2|Bacteria,2I5JI@201174|Actinobacteria,4D3AS@85005|Actinomycetales 201174|Actinobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_16478_1 1440774.Y900_015355 7.26e-26 107.0 COG3804@1|root,COG3804@2|Bacteria,2IBKQ@201174|Actinobacteria,2375W@1762|Mycobacteriaceae 201174|Actinobacteria S dihydrodipicolinate reductase - - 1.4.1.12,1.4.1.26 ko:K21672 ko00310,ko00330,ko00472,map00310,map00330,map00472 - R02825,R04200,R04201,R04687,R04688 RC00249,RC00790 ko00000,ko00001,ko01000 - - - DapB_N k59_455296_1 56780.SYN_02713 3.32e-25 106.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2MRG9@213462|Syntrophobacterales 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1143656_1 247490.KSU1_C0730 2.72e-05 52.0 COG2234@1|root,COG3291@1|root,COG3420@1|root,COG4409@1|root,COG5184@1|root,COG5276@1|root,COG2234@2|Bacteria,COG3291@2|Bacteria,COG3420@2|Bacteria,COG4409@2|Bacteria,COG5184@2|Bacteria,COG5276@2|Bacteria 2|Bacteria DZ guanyl-nucleotide exchange factor activity iap GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005623,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.2.1.4,3.4.11.10,3.4.11.24,3.4.11.6 ko:K01179,ko:K03929,ko:K09612,ko:K12287,ko:K19701,ko:K19702 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000,ko01002,ko02044 - CE10,GH5,GH9 - Beta_helix,Peptidase_M28 k59_1143660_1 436308.Nmar_1079 1.01e-117 344.0 COG1063@1|root,arCOG01459@2157|Archaea,41S98@651137|Thaumarchaeota 651137|Thaumarchaeota C Glucose dehydrogenase C-terminus - - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N k59_1143660_2 436308.Nmar_1080 3e-53 168.0 COG1436@1|root,arCOG04102@2157|Archaea,41T76@651137|Thaumarchaeota 651137|Thaumarchaeota C ATP synthase (F/14-kDa) subunit - - - ko:K02122 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_F k59_1143660_3 1229909.NSED_06295 3.9e-45 148.0 arCOG08700@1|root,arCOG08700@2157|Archaea,41SV2@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1145480_2 1304888.ATWF01000001_gene1337 4.75e-12 66.2 COG0811@1|root,COG0811@2|Bacteria,2GFCQ@200930|Deferribacteres 200930|Deferribacteres U MotA/TolQ/ExbB proton channel family - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_1188790_1 1123366.TH3_16179 1.21e-134 402.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2JPYX@204441|Rhodospirillales 204441|Rhodospirillales I COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit - - 6.4.1.3 ko:K01965 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1551439_1 225937.HP15_1803 4.8e-53 170.0 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,4676A@72275|Alteromonadaceae 1236|Gammaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_1551439_2 396588.Tgr7_0954 3.49e-51 172.0 COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,1RS4G@1236|Gammaproteobacteria,1WXQH@135613|Chromatiales 135613|Chromatiales Q PFAM methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_360703_1 1049564.TevJSym_au00470 1.51e-53 177.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1J54F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Catabolite gene activator and regulatory subunit of cAMP-dependent protein anr - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_360710_1 1049564.TevJSym_aj00280 4.76e-58 191.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1J4D5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Cell wall formation murB GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_1400473_1 243090.RB1274 5.78e-62 206.0 COG1902@1|root,COG1902@2|Bacteria,2IXBM@203682|Planctomycetes 203682|Planctomycetes C PFAM NADH flavin oxidoreductase NADH oxidase - - - - - - - - - - - - Oxidored_FMN k59_360712_1 768066.HELO_3780 1.18e-65 220.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1XHXZ@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_1252098_1 1123073.KB899241_gene1922 2.3e-18 78.6 COG3831@1|root,COG3831@2|Bacteria,1NGUF@1224|Proteobacteria,1T6H3@1236|Gammaproteobacteria,1X7H4@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - WGR k59_1607860_1 439235.Dalk_0381 2.11e-24 104.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria,2MJ0H@213118|Desulfobacterales 28221|Deltaproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1145521_1 234267.Acid_5749 9.62e-60 207.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 k59_1607861_1 411460.RUMTOR_00920 6.52e-30 122.0 COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,3XYQF@572511|Blautia 186801|Clostridia H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_774392_1 1267535.KB906767_gene5202 7.39e-33 130.0 COG0249@1|root,COG0249@2|Bacteria,3Y48T@57723|Acidobacteria,2JKU6@204432|Acidobacteriia 204432|Acidobacteriia L ATPase domain of DNA mismatch repair MUTS family - - - - - - - - - - - - MutS_III,MutS_V k59_411946_2 1089545.KB913037_gene1314 1.19e-42 150.0 COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4E1RW@85010|Pseudonocardiales 201174|Actinobacteria I Thiolase, C-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1551477_1 1121918.ARWE01000001_gene712 2.12e-30 120.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,42N10@68525|delta/epsilon subdivisions,2WJI9@28221|Deltaproteobacteria,43SAF@69541|Desulfuromonadales 28221|Deltaproteobacteria LU DNA recombination-mediator protein A dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_1459053_2 568816.Acin_1836 6.4e-32 124.0 COG0507@1|root,COG5323@1|root,COG0507@2|Bacteria,COG5323@2|Bacteria,1TQWH@1239|Firmicutes,4H656@909932|Negativicutes 909932|Negativicutes L Terminase RNaseH-like domain - - - - - - - - - - - - - k59_1400495_1 983920.Y88_0359 1.26e-94 295.0 COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2TSHG@28211|Alphaproteobacteria,2K1R5@204457|Sphingomonadales 204457|Sphingomonadales S ABC1 family - - - - - - - - - - - - ABC1 k59_253284_1 765912.Thimo_1291 2.23e-43 155.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1WWJ0@135613|Chromatiales 135613|Chromatiales F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_1252132_1 1163617.SCD_n00349 0.000437 41.6 COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,2VM8J@28216|Betaproteobacteria 28216|Betaproteobacteria C Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide nosZ - 1.7.2.4 ko:K00376 ko00910,ko01120,map00910,map01120 M00529 R02804 RC02861 ko00000,ko00001,ko00002,ko01000 - - - Cupredoxin_1 k59_1252132_2 768671.ThimaDRAFT_0915 2.33e-31 114.0 COG2863@1|root,COG2863@2|Bacteria,1N1DQ@1224|Proteobacteria,1SE2Q@1236|Gammaproteobacteria,1X19A@135613|Chromatiales 135613|Chromatiales C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_1400520_1 713587.THITH_03850 1.37e-61 209.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales 135613|Chromatiales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_21105_1 207954.MED92_01771 1.02e-25 107.0 COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,1RQJT@1236|Gammaproteobacteria,1XH77@135619|Oceanospirillales 135619|Oceanospirillales IQ Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_466406_1 391937.NA2_16298 5.66e-18 88.2 2DC0C@1|root,2ZC6W@2|Bacteria,1QZV7@1224|Proteobacteria,2TYEG@28211|Alphaproteobacteria,43RTD@69277|Phyllobacteriaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1188874_3 485913.Krac_7266 2.17e-20 88.6 COG3247@1|root,COG3247@2|Bacteria,2G8VA@200795|Chloroflexi 200795|Chloroflexi S Short repeat of unknown function (DUF308) - - - - - - - - - - - - DUF308 k59_308934_1 1380394.JADL01000001_gene2544 7.05e-118 352.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TUKZ@28211|Alphaproteobacteria,2JZ9Y@204441|Rhodospirillales 204441|Rhodospirillales J Amidase - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_152990_1 996637.SGM_6147 1.23e-15 82.0 COG2730@1|root,COG5297@1|root,COG2730@2|Bacteria,COG5297@2|Bacteria,2I2VY@201174|Actinobacteria 201174|Actinobacteria G Glycoside hydrolase family 5 celA - 3.2.1.4 ko:K01179,ko:K20628 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_2,Cellulase,fn3 k59_1092558_1 264462.Bd3244 1.34e-20 95.5 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,42R96@68525|delta/epsilon subdivisions,2MT8I@213481|Bdellovibrionales,2WMVV@28221|Deltaproteobacteria 213481|Bdellovibrionales M D-alanyl-D-alanine carboxypeptidase dacB - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_196997_1 743299.Acife_2717 1.76e-97 316.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,2NCSH@225057|Acidithiobacillales 225057|Acidithiobacillales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_197000_2 246197.MXAN_5115 4.67e-22 94.7 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,42RTC@68525|delta/epsilon subdivisions,2WNQ6@28221|Deltaproteobacteria,2YVHB@29|Myxococcales 28221|Deltaproteobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_412006_1 1122165.AUHS01000005_gene1724 1.71e-36 135.0 COG1926@1|root,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,1S3SH@1236|Gammaproteobacteria,1JD8H@118969|Legionellales 118969|Legionellales F Phosphoribosyl transferase domain - - - ko:K07100 - - - - ko00000 - - - Pribosyltran k59_412006_2 338969.Rfer_3853 5.8e-15 70.9 COG1371@1|root,COG1371@2|Bacteria,1RJU0@1224|Proteobacteria,2VU90@28216|Betaproteobacteria 28216|Betaproteobacteria S Archease protein family (MTH1598/TM1083) - - - - - - - - - - - - Archease k59_1345123_2 1173028.ANKO01000064_gene3110 4.49e-39 143.0 COG0451@1|root,COG0451@2|Bacteria,1G14S@1117|Cyanobacteria,1H7DX@1150|Oscillatoriales 1117|Cyanobacteria GM PFAM NAD dependent epimerase dehydratase family - - 4.2.1.46,5.1.3.2 ko:K01710,ko:K01784 ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00362,M00632,M00793 R00291,R02984,R06513 RC00289,RC00402 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_566230_1 1499967.BAYZ01000148_gene1748 0.000132 48.1 COG1538@1|root,COG1538@2|Bacteria,2NP5D@2323|unclassified Bacteria 2|Bacteria MU Outer membrane efflux protein tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_566230_2 1035308.AQYY01000001_gene1700 9.92e-11 62.8 COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia,261YY@186807|Peptococcaceae 186801|Clostridia I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS20335 IspD k59_466435_1 1589733.A0A0C5AMY0_9CAUD 3.46e-05 49.7 4QEU2@10239|Viruses,4QR1I@28883|Caudovirales,4QIW8@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1092581_1 908819.A0A0A0YNQ8_9CAUD 4.61e-96 305.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales 28883|Caudovirales S N-methyltransferase activity - - - - - - - - - - - - - k59_1400569_1 436308.Nmar_1014 2.09e-79 242.0 COG4742@1|root,arCOG04362@2157|Archaea,41SGE@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcriptional regulator - - - - - - - - - - - - HTH_20 k59_1092585_1 1266925.JHVX01000003_gene642 2.32e-97 313.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,372Q5@32003|Nitrosomonadales 28216|Betaproteobacteria F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_197037_1 977880.RALTA_A1111 6.4e-40 149.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,1K174@119060|Burkholderiaceae 28216|Betaproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_1145639_1 1499680.CCFE01000023_gene2535 5.22e-23 101.0 COG2843@1|root,COG2843@2|Bacteria,1UCFI@1239|Firmicutes,4HE5R@91061|Bacilli,1ZRPK@1386|Bacillus 91061|Bacilli M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_412042_1 1267211.KI669560_gene1523 9.62e-112 345.0 COG1770@1|root,COG1770@2|Bacteria,4NEQS@976|Bacteroidetes,1IQQY@117747|Sphingobacteriia 976|Bacteroidetes E Peptidase S9, prolyl oligopeptidase, catalytic domain ptrB - 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_982739_1 1458427.BAWN01000012_gene704 2.89e-72 234.0 COG3581@1|root,COG3581@2|Bacteria,1R7UD@1224|Proteobacteria 1224|Proteobacteria I 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - - k59_197055_2 59538.XP_005968778.1 6.12e-102 308.0 COG1062@1|root,KOG0022@2759|Eukaryota,397PJ@33154|Opisthokonta,3BIQH@33208|Metazoa,3CYWE@33213|Bilateria,4871P@7711|Chordata,491PB@7742|Vertebrata,3J1Y5@40674|Mammalia 2759|Eukaryota Q alcohol dehydrogenase (NAD) activity ADH1 GO:0000302,GO:0001101,GO:0001666,GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006970,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009410,GO:0009413,GO:0009414,GO:0009415,GO:0009628,GO:0009636,GO:0009651,GO:0009719,GO:0009725,GO:0009737,GO:0009743,GO:0009744,GO:0010033,GO:0010035,GO:0010038,GO:0010243,GO:0014070,GO:0014074,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0031000,GO:0032355,GO:0033993,GO:0034285,GO:0036270,GO:0036293,GO:0042221,GO:0042493,GO:0042542,GO:0042802,GO:0042803,GO:0043279,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046686,GO:0046983,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0055114,GO:0065007,GO:0070482,GO:0071944,GO:0080134,GO:0080135,GO:0097305,GO:1900037,GO:1900039,GO:1901698,GO:1901700 1.1.1.1,1.1.1.284 ko:K00001,ko:K00121,ko:K02267,ko:K13980,ko:K18857 ko00010,ko00071,ko00190,ko00350,ko00592,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,ko05204,map00010,map00071,map00190,map00350,map00592,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map04260,map04714,map04932,map05010,map05012,map05016,map05204 M00154 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310,R10783 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko00002,ko01000 3.D.4.11,3.D.4.8 - - ADH_N,ADH_zinc_N k59_1188952_1 616991.JPOO01000001_gene3785 5.24e-33 127.0 COG1619@1|root,COG1619@2|Bacteria,4NF5Q@976|Bacteroidetes,1HXC6@117743|Flavobacteriia,23FYP@178469|Arenibacter 976|Bacteroidetes V LD-carboxypeptidase - - 3.4.17.13 ko:K01297 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S66 k59_1400599_1 1157708.KB907462_gene877 1.45e-06 51.6 COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,2VX02@28216|Betaproteobacteria 28216|Betaproteobacteria T Prokaryotic dksA/traR C4-type zinc finger - - - - - - - - - - - - zf-dskA_traR k59_1400599_2 335543.Sfum_3311 7.4e-59 194.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,42MHX@68525|delta/epsilon subdivisions,2WIKS@28221|Deltaproteobacteria,2MQ83@213462|Syntrophobacterales 28221|Deltaproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_360850_1 1415166.NONO_c57260 1.08e-07 59.3 COG0515@1|root,COG0515@2|Bacteria,2GNXG@201174|Actinobacteria,4FW88@85025|Nocardiaceae 201174|Actinobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K08884 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_725404_1 1141662.OOA_09613 1.58e-08 57.4 COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,3Z7I8@586|Providencia 1236|Gammaproteobacteria V Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008144,GO:0008150,GO:0008559,GO:0015238,GO:0015399,GO:0015405,GO:0015893,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902495,GO:1990195,GO:1990196,GO:1990351 - ko:K05685 ko02010,map02010 M00709 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.122.1,3.A.1.122.12 - - ABC_tran,FtsX,MacB_PCD k59_253385_1 754477.Q7C_1099 3.27e-22 90.1 COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,1S5X6@1236|Gammaproteobacteria,460RV@72273|Thiotrichales 72273|Thiotrichales T Low molecular weight phosphotyrosine protein phosphatase yfkJ - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc k59_1188986_1 679197.HMPREF9336_02466 2.8e-71 231.0 COG1012@1|root,COG1012@2|Bacteria,2GT45@201174|Actinobacteria 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family pcd - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_412089_1 1123355.JHYO01000003_gene2882 4.19e-83 265.0 COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,2TV6G@28211|Alphaproteobacteria,36XJQ@31993|Methylocystaceae 28211|Alphaproteobacteria O Carbamoyltransferase C-terminus - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_412089_3 1430440.MGMSRv2_3469 1.22e-24 98.2 2E3ZS@1|root,32YWP@2|Bacteria,1NAZV@1224|Proteobacteria,2UGW3@28211|Alphaproteobacteria,2JXCF@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_1345215_1 396588.Tgr7_2066 3.48e-92 288.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_936170_1 985053.VMUT_1156 6.6e-15 80.1 COG1574@1|root,arCOG00691@2157|Archaea 2157|Archaea S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_1551629_1 1121937.AUHJ01000013_gene863 5.42e-110 335.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RPIW@1236|Gammaproteobacteria,46464@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 k59_936178_1 861299.J421_0468 7.57e-45 166.0 COG0515@1|root,COG0515@2|Bacteria,1ZUHT@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_21159_1 472759.Nhal_2290 4.28e-81 262.0 COG4590@1|root,COG4590@2|Bacteria,1QTTD@1224|Proteobacteria,1T1GK@1236|Gammaproteobacteria,1WXXX@135613|Chromatiales 135613|Chromatiales P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_566314_1 1267535.KB906767_gene5393 2.04e-23 93.2 COG3415@1|root,COG3415@2|Bacteria,3Y8WI@57723|Acidobacteria 57723|Acidobacteria L Winged helix-turn helix - - - - - - - - - - - - HTH_33 k59_566314_2 1267535.KB906767_gene2036 5.49e-34 123.0 COG3335@1|root,COG3335@2|Bacteria 2|Bacteria L DDE superfamily endonuclease - - - ko:K07494 - - - - ko00000 - - - DDE_3 k59_1459222_1 935866.JAER01000026_gene3196 2.31e-42 148.0 COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,4DRDC@85009|Propionibacteriales 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_619163_1 1217718.ALOU01000007_gene1259 3.22e-58 192.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2VM5U@28216|Betaproteobacteria,1KF02@119060|Burkholderiaceae 28216|Betaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_412120_1 378806.STAUR_0531 9.86e-159 473.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42Z54@68525|delta/epsilon subdivisions,2WUB9@28221|Deltaproteobacteria,2YYC4@29|Myxococcales 28221|Deltaproteobacteria J Anticodon-binding domain of tRNA valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_1145743_1 497964.CfE428DRAFT_4964 7.86e-08 51.6 COG2165@1|root,COG2165@2|Bacteria,46T8M@74201|Verrucomicrobia 74201|Verrucomicrobia NU general secretion pathway protein - - - - - - - - - - - - N_methyl k59_315381_1 1403819.BATR01000017_gene538 4.35e-44 147.0 COG1764@1|root,COG1764@2|Bacteria,46VXJ@74201|Verrucomicrobia,2IW5Z@203494|Verrucomicrobiae 203494|Verrucomicrobiae O OsmC-like protein - - - - - - - - - - - - OsmC k59_524260_1 1232410.KI421412_gene51 2.59e-70 234.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,43T3K@69541|Desulfuromonadales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-3 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_158005_1 1193729.A1OE_156 1.17e-33 131.0 COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,2TT1M@28211|Alphaproteobacteria,2JSK8@204441|Rhodospirillales 204441|Rhodospirillales P transport protein CorA corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_315383_1 1121943.KB899992_gene2075 3.42e-51 175.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1XHAH@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,Pribosyltran k59_315383_2 391615.ABSJ01000054_gene1423 3.24e-07 52.4 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Colicin v production cvpA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 - ko:K03558 - - - - ko00000 - - - Colicin_V k59_994028_1 1122604.JONR01000006_gene2668 2.06e-64 199.0 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,1S3Q2@1236|Gammaproteobacteria,1X6JV@135614|Xanthomonadales 135614|Xanthomonadales J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_994028_2 1123368.AUIS01000013_gene859 3.22e-37 130.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,2NCQQ@225057|Acidithiobacillales 225057|Acidithiobacillales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_629208_1 1335757.SPICUR_07680 1.94e-25 99.4 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,1WYVR@135613|Chromatiales 135613|Chromatiales K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ k59_890045_1 1191523.MROS_0480 1.12e-80 268.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria 2|Bacteria M serine-type peptidase activity - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ k59_1360149_1 767434.Fraau_2478 9.4e-101 311.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1X2YR@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_994036_1 1122179.KB890430_gene4299 4.63e-05 45.4 COG0564@1|root,COG0564@2|Bacteria,4NHKH@976|Bacteroidetes,1IQTT@117747|Sphingobacteriia 976|Bacteroidetes J Pseudouridine synthase - - 5.4.99.23,5.4.99.24 ko:K06179,ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_994036_2 743525.TSC_c01580 7.85e-20 90.1 COG1496@1|root,COG1496@2|Bacteria,1WI9I@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Belongs to the multicopper oxidase YfiH RL5 family - GO:0003674,GO:0005488,GO:0005507,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_524275_1 477641.MODMU_0419 2.98e-12 74.7 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - ko:K00786 - - - - ko00000,ko01000 - - - GFO_IDH_MocA,Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_1150868_2 1485545.JQLW01000005_gene1165 1.5e-19 84.3 COG0347@1|root,COG0347@2|Bacteria,1RG6J@1224|Proteobacteria 1224|Proteobacteria K Nitrogen regulatory protein P-II - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_1150868_3 1249997.JHZW01000001_gene4144 1.05e-06 51.6 COG0334@1|root,COG0334@2|Bacteria,4NEBH@976|Bacteroidetes,1HX4B@117743|Flavobacteriia,2PIET@252356|Maribacter 976|Bacteroidetes E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_1390_1 545695.TREAZ_3266 4.34e-27 115.0 COG3119@1|root,COG3119@2|Bacteria,2J7YX@203691|Spirochaetes 203691|Spirochaetes P PFAM sulfatase - - - - - - - - - - - - Sulfatase k59_263147_1 472759.Nhal_0766 2.63e-10 63.2 COG2267@1|root,COG2267@2|Bacteria,1N2R9@1224|Proteobacteria,1T1K8@1236|Gammaproteobacteria,1X2NI@135613|Chromatiales 135613|Chromatiales I The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters bioH - 3.1.1.85 ko:K02170 ko00780,ko01100,map00780,map01100 M00572 R09725 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_263147_2 768671.ThimaDRAFT_3356 1.71e-16 78.2 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales 135613|Chromatiales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_629226_1 1487953.JMKF01000028_gene1244 1.78e-26 112.0 COG0845@1|root,COG0845@2|Bacteria,1FZXD@1117|Cyanobacteria,1H6YI@1150|Oscillatoriales 1117|Cyanobacteria M ABC exporter membrane fusion protein, DevB family - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1391_2 2340.JV46_24700 3.95e-42 140.0 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,1SCTJ@1236|Gammaproteobacteria,1JAXW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sulphur oxidation protein SoxZ soxZ - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_106078_1 305700.B447_07337 2.64e-50 166.0 COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,2VIDX@28216|Betaproteobacteria,2KU7I@206389|Rhodocyclales 206389|Rhodocyclales L Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH - - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX k59_1046663_1 1218084.BBJK01000006_gene742 2.89e-82 261.0 COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,1JZXA@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_1046663_2 1286631.X805_03550 5.21e-50 169.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2VH0T@28216|Betaproteobacteria,1KJNT@119065|unclassified Burkholderiales 28216|Betaproteobacteria Q dienelactone hydrolase clcD - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_315423_1 251221.35212025 5.32e-07 58.2 COG0702@1|root,COG0702@2|Bacteria,1G1X9@1117|Cyanobacteria 1117|Cyanobacteria GM PFAM NmrA-like family - - - - - - - - - - - - NAD_binding_10 k59_1516110_1 1442599.JAAN01000032_gene1578 1.83e-34 127.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1X3Z0@135614|Xanthomonadales 135614|Xanthomonadales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_1516110_2 1123487.KB892857_gene2310 2.83e-34 124.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2VQNU@28216|Betaproteobacteria,2KV6M@206389|Rhodocyclales 206389|Rhodocyclales J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_158028_1 1232683.ADIMK_0247 1.33e-58 208.0 COG1025@1|root,COG1025@2|Bacteria,1QTVC@1224|Proteobacteria,1T1IG@1236|Gammaproteobacteria,4641E@72275|Alteromonadaceae 1236|Gammaproteobacteria O Belongs to the peptidase M16 family ptrA - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C,Peptidase_M16_M k59_54647_1 123899.JPQP01000023_gene3239 5.5e-22 95.9 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2VJN2@28216|Betaproteobacteria,3T1QF@506|Alcaligenaceae 28216|Betaproteobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_263176_1 909663.KI867150_gene1837 2.92e-94 306.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,42M6A@68525|delta/epsilon subdivisions,2WJIT@28221|Deltaproteobacteria,2MQBG@213462|Syntrophobacterales 28221|Deltaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_629260_1 324057.Pjdr2_4360 6.26e-47 169.0 COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,4H9SB@91061|Bacilli,26QIQ@186822|Paenibacillaceae 91061|Bacilli S Hemolysins and related proteins containing CBS domains corC3 - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1307522_1 1493510.A0A0E3F215_9CAUD 6.63e-40 155.0 4QFBI@10239|Viruses,4QRAS@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_733322_1 243090.RB1736 1.87e-06 56.2 COG3119@1|root,COG3119@2|Bacteria,2J1R8@203682|Planctomycetes 203682|Planctomycetes P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_524313_1 1229909.NSED_02620 1.81e-113 327.0 COG1386@1|root,arCOG02613@2157|Archaea,41SIC@651137|Thaumarchaeota 651137|Thaumarchaeota K segregation and condensation protein - - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_1401_1 483219.LILAB_02900 1.96e-50 181.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42N0H@68525|delta/epsilon subdivisions,2WIYD@28221|Deltaproteobacteria,2YTYJ@29|Myxococcales 28221|Deltaproteobacteria S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_419839_2 1163617.SCD_n02571 7.12e-65 215.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2VH1I@28216|Betaproteobacteria 28216|Betaproteobacteria M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_1516120_1 196367.JNFG01000002_gene2268 1.75e-90 284.0 COG0318@1|root,COG0318@2|Bacteria,1MWSD@1224|Proteobacteria,2VHE3@28216|Betaproteobacteria,1K46A@119060|Burkholderiaceae 28216|Betaproteobacteria IQ AMP-binding enzyme - - 6.2.1.48 ko:K02182 - - - - ko00000,ko01000 - - - AMP-binding,AMP-binding_C k59_1150913_1 396595.TK90_0435 1.85e-89 280.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1WW6M@135613|Chromatiales 135613|Chromatiales O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_837760_1 306281.AJLK01000062_gene4946 3.72e-134 389.0 COG1209@1|root,COG1209@2|Bacteria,1G091@1117|Cyanobacteria 1117|Cyanobacteria M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_837760_2 1321781.HMPREF1985_00430 1.15e-15 76.3 COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,4H3A2@909932|Negativicutes 909932|Negativicutes M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_263191_1 1112274.KI911560_gene2095 3.14e-21 100.0 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2WGP8@28216|Betaproteobacteria 28216|Betaproteobacteria P TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_629272_1 85643.Tmz1t_3870 6.2e-151 452.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria 28216|Betaproteobacteria P Pfam Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_471699_1 134676.ACPL_5084 2.82e-20 95.1 COG4867@1|root,COG4867@2|Bacteria,2H14W@201174|Actinobacteria,4DBI4@85008|Micromonosporales 201174|Actinobacteria S protein with a von Willebrand factor type A (vWA) domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - VWA_2 k59_1046703_1 105559.Nwat_2842 9.63e-51 178.0 COG0125@1|root,COG0125@2|Bacteria,1R6BR@1224|Proteobacteria,1RSID@1236|Gammaproteobacteria 1236|Gammaproteobacteria F ATP binding yghR - - - - - - - - - - - Thymidylate_kin k59_471703_1 404589.Anae109_1359 2.51e-70 221.0 COG1830@1|root,COG1830@2|Bacteria,1MW9N@1224|Proteobacteria,42PEB@68525|delta/epsilon subdivisions,2WM0Y@28221|Deltaproteobacteria,2Z349@29|Myxococcales 28221|Deltaproteobacteria G DeoC/LacD family aldolase fbaB - 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - DeoC k59_837772_2 580332.Slit_1533 2.07e-33 126.0 COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,2VRAS@28216|Betaproteobacteria,44VRZ@713636|Nitrosomonadales 28216|Betaproteobacteria EH Amino-transferase class IV pabC - 4.1.3.38 ko:K02619 ko00790,map00790 - R05553 RC01843,RC02148 ko00000,ko00001,ko01000 - - - Aminotran_4 k59_54687_1 1229780.BN381_290057 5.35e-52 172.0 COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,3UXH6@52018|unclassified Actinobacteria (class) 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_54687_2 2002.JOEQ01000060_gene7043 9.72e-23 92.4 COG2030@1|root,COG2030@2|Bacteria,2IHRG@201174|Actinobacteria,4EJCT@85012|Streptosporangiales 201174|Actinobacteria I MaoC like domain - - - - - - - - - - - - MaoC_dehydratas k59_681514_1 268746.Q58MM5_BPPRM 2.9e-37 139.0 4QAZ6@10239|Viruses,4QUU8@35237|dsDNA viruses no RNA stage,4QPHV@28883|Caudovirales,4QI4H@10662|Myoviridae 10662|Myoviridae S Phage tail sheath protein - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098027 - - - - - - - - - - - k59_681514_2 444860.E3SJ05_9CAUD 2.79e-28 103.0 4QIZ2@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1203850_1 756272.Plabr_3034 2.18e-40 149.0 COG0591@1|root,COG0591@2|Bacteria,2J22E@203682|Planctomycetes 203682|Planctomycetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_55757_2 631362.Thi970DRAFT_01080 3.21e-91 276.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1WWPW@135613|Chromatiales 135613|Chromatiales E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_1308411_1 765913.ThidrDRAFT_4467 6.42e-128 395.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WXV4@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1765_1 298655.KI912266_gene28 4.67e-58 194.0 COG1012@1|root,COG1012@2|Bacteria,2GJI2@201174|Actinobacteria,4ES6D@85013|Frankiales 201174|Actinobacteria C PFAM Aldehyde dehydrogenase mmsA - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_420775_1 595593.JREV01000001_gene2606 5.7e-07 56.6 COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,1W8KD@1268|Micrococcaceae 201174|Actinobacteria KLT Serine threonine protein kinase pknB GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_1465653_1 1502852.FG94_00188 8.17e-07 55.5 COG3203@1|root,COG3203@2|Bacteria,1R6MS@1224|Proteobacteria,2VMAA@28216|Betaproteobacteria,475YN@75682|Oxalobacteraceae 28216|Betaproteobacteria M Gram-negative porin - - - - - - - - - - - - Porin_4 k59_1099951_1 398527.Bphyt_3380 4.37e-06 50.8 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,1K2G2@119060|Burkholderiaceae 28216|Betaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_1099951_2 502025.Hoch_1967 4.32e-51 169.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,42M0U@68525|delta/epsilon subdivisions,2WJR5@28221|Deltaproteobacteria,2Z0KD@29|Myxococcales 28221|Deltaproteobacteria M ion channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - LysM,MS_channel,TM_helix k59_1204935_1 748247.AZKH_1894 7.41e-68 223.0 COG0318@1|root,COG0318@2|Bacteria,1MWSD@1224|Proteobacteria,2VHE3@28216|Betaproteobacteria,2KYPH@206389|Rhodocyclales 206389|Rhodocyclales IQ AMP-binding enzyme - - 6.2.1.48 ko:K02182 - - - - ko00000,ko01000 - - - AMP-binding,AMP-binding_C k59_472549_1 1122603.ATVI01000005_gene3040 2.06e-33 130.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1X4NW@135614|Xanthomonadales 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_1361091_1 1000565.METUNv1_02983 1.15e-61 199.0 COG2972@1|root,COG2972@2|Bacteria,1QYRK@1224|Proteobacteria,2WHJ2@28216|Betaproteobacteria 28216|Betaproteobacteria T Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365,HAMP k59_1361091_2 395494.Galf_1180 1.22e-11 65.1 COG2114@1|root,COG2114@2|Bacteria,1RD0X@1224|Proteobacteria,2VS0D@28216|Betaproteobacteria,44VWF@713636|Nitrosomonadales 28216|Betaproteobacteria T adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - Guanylate_cyc,PEGA k59_1768_2 583355.Caka_2847 1.19e-51 167.0 COG1017@1|root,COG1017@2|Bacteria,46Z2G@74201|Verrucomicrobia,3K9UI@414999|Opitutae 414999|Opitutae C nitric oxide dioxygenase activity - - - - - - - - - - - - - k59_264114_1 1499967.BAYZ01000080_gene919 3.61e-95 298.0 COG3533@1|root,COG3533@2|Bacteria,2NNW0@2323|unclassified Bacteria 2|Bacteria S Beta-L-arabinofuranosidase, GH127 - - - - - - - - - - - - Glyco_hydro_127 k59_55777_2 1384054.N790_02540 5.87e-16 83.6 COG0457@1|root,COG0457@2|Bacteria,1QRIQ@1224|Proteobacteria,1T90E@1236|Gammaproteobacteria,1XBHE@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16 k59_107001_1 1384056.N787_06675 2.79e-22 91.3 COG1366@1|root,COG1366@2|Bacteria,1PCVS@1224|Proteobacteria,1SCT3@1236|Gammaproteobacteria,1X73U@135614|Xanthomonadales 135614|Xanthomonadales T Belongs to the anti-sigma-factor antagonist family spoIIAA - - - - - - - - - - - STAS,STAS_2 k59_1475980_1 5507.FOXG_17350P0 1.53e-13 75.1 COG1960@1|root,KOG0139@2759|Eukaryota,38HBF@33154|Opisthokonta,3NX0Q@4751|Fungi,3QNBP@4890|Ascomycota 4751|Fungi E Dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1056213_1 1229909.NSED_09235 7.77e-52 169.0 arCOG03788@1|root,arCOG03788@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - LEA_2 k59_1215311_1 287986.DV20_07095 3.47e-42 154.0 COG1819@1|root,COG1819@2|Bacteria,2GJMF@201174|Actinobacteria,4DX4R@85010|Pseudonocardiales 201174|Actinobacteria CG lipid glycosylation - GO:0003674,GO:0003824,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0016999,GO:0017000,GO:0017144,GO:0019184,GO:0030650,GO:0030651,GO:0033071,GO:0033072,GO:0034641,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.310,2.4.1.311 ko:K16440,ko:K16444 ko01055,map01055 - - - ko00000,ko00001,ko01000 - GT1 - Glyco_tran_28_C,Glyco_transf_28,UDPGT k59_1056218_1 1224318.DT73_22040 3.96e-64 209.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,1RQ9W@1236|Gammaproteobacteria 1236|Gammaproteobacteria L to Escherichia coli transposase for insertion sequence element IS21 IstA SW ISTA_ECOLI (P15025) (390 aa) fasta scores E() 3e-27, 33.1 id in 329 aa. Identical to the previously sequenced Yersinia pestis,Yersinia pseudotuberculosis and Escherichia coli pesticin plasmid insertion sequence transposase Y1055 TR P74993 (EMBL U59875) (340 aa) fasta scores E() 0, 100.0 id in 340 aa - - - - - - - - - - - - HTH_23,rve k59_742339_1 985054.JQEZ01000001_gene2929 2.5e-96 305.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,4NAMS@97050|Ruegeria 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_585776_1 1049564.TevJSym_at00260 2.62e-85 267.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1J4GC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - iECSE_1348.ECSE_3895,iJN746.PP_5056 Metalloenzyme,Phosphodiest,iPGM_N k59_798248_1 1380355.JNIJ01000090_gene2461 3.32e-65 226.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_325355_1 1121878.AUGL01000010_gene1020 1.35e-39 147.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Single-stranded-DNA-specific exonuclease recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_533392_2 1347392.CCEZ01000014_gene2731 1.01e-37 145.0 COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,36E3Q@31979|Clostridiaceae 186801|Clostridia E Dehydrogenase - - 1.1.1.103,1.1.1.14 ko:K00008,ko:K00060 ko00040,ko00051,ko00260,ko01100,map00040,map00051,map00260,map01100 M00014 R00875,R01465,R01896 RC00085,RC00102,RC00525 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N,Glu_dehyd_C k59_533392_3 1123504.JQKD01000083_gene51 4.9e-42 142.0 COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,2VR9M@28216|Betaproteobacteria,4AE0U@80864|Comamonadaceae 28216|Betaproteobacteria I Thioesterase superfamily protein yciA - - ko:K10806 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT k59_5131_1 1120956.JHZK01000003_gene265 7.33e-34 133.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,1JN5E@119043|Rhodobiaceae 28211|Alphaproteobacteria O Trypsin degP GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_377208_1 936455.KI421499_gene8053 1.21e-89 300.0 COG2114@1|root,COG3899@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,COG3903@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain MA20_09880 - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1,TPR_4 k59_1577817_1 321332.CYB_1375 4.64e-39 149.0 COG1501@1|root,COG1501@2|Bacteria,1G3UD@1117|Cyanobacteria,1H2JX@1129|Synechococcus 1117|Cyanobacteria G Belongs to the glycosyl hydrolase 31 family - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31 k59_585787_1 330214.NIDE1248 3.43e-72 222.0 COG1734@1|root,COG1734@2|Bacteria,3J0R1@40117|Nitrospirae 40117|Nitrospirae T Prokaryotic dksA/traR C4-type zinc finger - - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_585787_2 330214.NIDE1249 3.61e-16 76.3 COG0603@1|root,COG0603@2|Bacteria,3J0NP@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_798264_1 436308.Nmar_0020 6.34e-88 265.0 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon k59_1369364_1 297246.lpp1964 3.59e-56 190.0 COG3173@1|root,COG3173@2|Bacteria,1QYB1@1224|Proteobacteria,1T3NR@1236|Gammaproteobacteria,1JFKC@118969|Legionellales 118969|Legionellales S Aminoglycoside phosphotransferase - - - - - - - - - - - - - k59_482269_1 1120988.AXWV01000011_gene711 2.52e-06 48.9 COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,1RNI1@1236|Gammaproteobacteria,1Y3Y2@135624|Aeromonadales 135624|Aeromonadales S Specifically methylates the adenine in position 2030 of 23S rRNA rlmJ - 2.1.1.266 ko:K07115 - - - - ko00000,ko01000,ko03009 - - - RsmJ k59_482269_2 42565.FP66_11490 8.96e-39 133.0 COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,1S8RW@1236|Gammaproteobacteria,1XM9X@135619|Oceanospirillales 135619|Oceanospirillales S MazG-like family - - - - - - - - - - - - MazG-like k59_482269_3 316056.RPC_0091 7.76e-26 104.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2TU3I@28211|Alphaproteobacteria,3JT59@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C oxidase, subunit II cydB - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_950993_1 220341.16504350 2.92e-23 99.8 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,3ZK21@590|Salmonella 1236|Gammaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_950993_2 391600.ABRU01000061_gene2073 1.02e-52 171.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria,2KGMZ@204458|Caulobacterales 204458|Caulobacterales F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_1267977_1 330214.NIDE1077 1.1e-66 226.0 COG0060@1|root,COG0060@2|Bacteria,3J0BF@40117|Nitrospirae 40117|Nitrospirae J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_1056241_1 1300345.LF41_1527 3.62e-201 575.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1X43R@135614|Xanthomonadales 135614|Xanthomonadales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_482273_1 344747.PM8797T_27954 6.5e-63 209.0 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,PRiA4_ORF3,zf-IS66 k59_272656_1 1121937.AUHJ01000001_gene501 9.94e-76 233.0 COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Protein of unknown function (DUF3501) - - - - - - - - - - - - DUF3501 k59_272656_2 1266925.JHVX01000009_gene53 1.31e-07 52.8 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VJ6T@28216|Betaproteobacteria,372WA@32003|Nitrosomonadales 28216|Betaproteobacteria C Cysteine-rich domain - - - - - - - - - - - - CCG,DUF3501 k59_1159806_1 1500890.JQNL01000001_gene1264 4.78e-21 97.1 COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,1RMMI@1236|Gammaproteobacteria,1X30G@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase pilS - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_742364_2 794903.OPIT5_19875 1.11e-42 157.0 28MGX@1|root,2ZATZ@2|Bacteria,46TJV@74201|Verrucomicrobia,3K7EP@414999|Opitutae 414999|Opitutae - - - - - - - - - - - - - - - k59_273443_1 710111.FraQA3DRAFT_1439 3.4e-10 60.8 COG1804@1|root,COG1804@2|Bacteria,2IHED@201174|Actinobacteria 201174|Actinobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_273443_2 595537.Varpa_2120 1.02e-75 239.0 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,4AD3D@80864|Comamonadaceae 28216|Betaproteobacteria I Enoyl-CoA hydratase carnithine racemase - - - - - - - - - - - - ECH_1 k59_1269038_1 761193.Runsl_3584 8.8e-69 227.0 COG1232@1|root,COG1232@2|Bacteria,4NEPC@976|Bacteroidetes,47KG9@768503|Cytophagia 976|Bacteroidetes H PFAM Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase k59_1004289_1 313628.LNTAR_23539 1.76e-22 100.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity fadL - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_430035_1 370438.PTH_2911 1.15e-10 63.9 COG1641@1|root,COG1641@2|Bacteria,1V4CM@1239|Firmicutes,24Q1I@186801|Clostridia,266VM@186807|Peptococcaceae 186801|Clostridia S Protein of unknown function DUF111 - - 4.99.1.12 ko:K09121 - - - - ko00000,ko01000 - - - DUF111 k59_430035_2 1144275.COCOR_07354 2.55e-24 100.0 COG1647@1|root,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,42NBK@68525|delta/epsilon subdivisions,2WIUP@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Serine aminopeptidase, S33 - - 3.1.1.1 ko:K03928 - - - - ko00000,ko01000 - - - Acyltransferase,Hydrolase_4 k59_1578754_1 1229909.NSED_07405 1.99e-82 261.0 COG0598@1|root,arCOG02265@2157|Archaea 2157|Archaea P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_221219_1 686340.Metal_0913 8.3e-51 174.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1XENU@135618|Methylococcales 135618|Methylococcales H PFAM Aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_378157_2 550540.Fbal_2607 3.29e-31 117.0 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Colicin v production cvpA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 - ko:K03558 - - - - ko00000 - - - Colicin_V k59_1160505_2 572477.Alvin_0439 8.98e-40 135.0 COG2010@1|root,COG2010@2|Bacteria,1NDHN@1224|Proteobacteria,1S700@1236|Gammaproteobacteria,1WYGG@135613|Chromatiales 135613|Chromatiales C Planctomycete cytochrome C - - - - - - - - - - - - PSCyt1 k59_799349_1 1229909.NSED_01430 4.04e-06 47.4 COG0260@1|root,arCOG04322@2157|Archaea,41SYD@651137|Thaumarchaeota 651137|Thaumarchaeota E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_1160509_1 1131812.JQMS01000001_gene148 8.83e-14 77.4 COG1345@1|root,COG2273@1|root,COG3209@1|root,COG3291@1|root,COG4886@1|root,COG4932@1|root,COG5492@1|root,COG1345@2|Bacteria,COG2273@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG4886@2|Bacteria,COG4932@2|Bacteria,COG5492@2|Bacteria,4NHMH@976|Bacteroidetes,1IIJN@117743|Flavobacteriia,2P0DQ@237|Flavobacterium 976|Bacteroidetes N Leucine-rich repeat (LRR) protein - - - - - - - - - - - - Big_2,DUF3494,HYR,Laminin_G_3 k59_1477122_1 338963.Pcar_3003 6.68e-81 266.0 COG1538@1|root,COG1538@2|Bacteria,1MYXE@1224|Proteobacteria,42TA7@68525|delta/epsilon subdivisions,2WR7T@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Outer membrane efflux protein - - - - - - - - - - - - OEP k59_951962_1 383372.Rcas_3859 1.08e-51 176.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_5,DDE_Tnp_1 k59_67778_1 228405.HNE_2181 3.44e-05 51.2 COG1737@1|root,COG1737@2|Bacteria,1MW2B@1224|Proteobacteria,2TV88@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator - - - - - - - - - - - - HTH_6,SIS k59_534366_1 436308.Nmar_1766 1.53e-51 179.0 arCOG02362@1|root,arCOG07810@1|root,arCOG02362@2157|Archaea,arCOG07810@2157|Archaea,41T0S@651137|Thaumarchaeota 651137|Thaumarchaeota N Adenylate guanylate cyclase with integral membrane sensor - - - - - - - - - - - - Guanylate_cyc,HAMP k59_221240_1 288000.BBta_4342 7.52e-62 217.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,3JTGV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Sulfotransfer_3,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_1004310_1 626887.J057_10371 2.41e-115 344.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1S1KY@1236|Gammaproteobacteria,465ZY@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG2230 Cyclopropane fatty acid synthase and related methyltransferases cfa2 - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_951963_1 1408428.JNJP01000013_gene1193 1.29e-51 180.0 COG0739@1|root,COG0739@2|Bacteria,1NESH@1224|Proteobacteria,42MGB@68525|delta/epsilon subdivisions,2WJ7F@28221|Deltaproteobacteria,2M7ZK@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Peptidase M23 - - - - - - - - - - - - Peptidase_M23 k59_273482_1 331678.Cphamn1_0469 1e-29 115.0 COG0679@1|root,COG0679@2|Bacteria,1FEJS@1090|Chlorobi 1090|Chlorobi S PFAM Auxin Efflux Carrier - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_693103_1 179408.Osc7112_4698 2.76e-44 157.0 COG0463@1|root,COG0463@2|Bacteria,1G4BG@1117|Cyanobacteria,1H8D9@1150|Oscillatoriales 1117|Cyanobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_743302_1 1147.D082_31730 1.55e-07 57.4 COG2242@1|root,COG2242@2|Bacteria,1G59A@1117|Cyanobacteria,1H6CU@1142|Synechocystis 1117|Cyanobacteria H Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21 k59_166870_1 1174684.EBMC1_08256 3.51e-14 75.9 COG4094@1|root,COG4094@2|Bacteria,1RDF9@1224|Proteobacteria,2U7NM@28211|Alphaproteobacteria,2K2CX@204457|Sphingomonadales 204457|Sphingomonadales S NnrU protein - - - - - - - - - - - - NnrU k59_743303_1 365528.KB891252_gene5748 1.81e-77 242.0 COG2141@1|root,COG2141@2|Bacteria,2IB10@201174|Actinobacteria,4ET8S@85013|Frankiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1370326_1 1279017.AQYJ01000029_gene3770 2.31e-54 182.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,464VS@72275|Alteromonadaceae 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluC GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1269114_1 1869.MB27_28275 8.07e-22 100.0 COG1404@1|root,COG1404@2|Bacteria,2GIRE@201174|Actinobacteria 201174|Actinobacteria O Belongs to the peptidase S8 family mycP - - ko:K14645,ko:K14743 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Peptidase_S8 k59_166873_2 945713.IALB_1589 6.8e-47 164.0 COG1192@1|root,COG1192@2|Bacteria 2|Bacteria D plasmid maintenance soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1423624_1 56780.SYN_01473 7.33e-37 137.0 COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,42M0K@68525|delta/epsilon subdivisions,2WISR@28221|Deltaproteobacteria,2MR8E@213462|Syntrophobacterales 28221|Deltaproteobacteria NU ATP synthase alpha/beta family, nucleotide-binding domain fliI - 3.6.3.14 ko:K02412,ko:K03224 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 - - ko00000,ko00001,ko00002,ko01000,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 - - ATP-synt_ab,ATP-synt_ab_N k59_534400_1 870187.Thini_2282 3.69e-74 237.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,461X5@72273|Thiotrichales 72273|Thiotrichales S Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_483497_1 1216976.AX27061_3155 3.32e-181 526.0 COG0028@1|root,COG0028@2|Bacteria,1MWUB@1224|Proteobacteria,2VMC1@28216|Betaproteobacteria,3T5NB@506|Alcaligenaceae 28216|Betaproteobacteria EH Belongs to the TPP enzyme family xsc - 2.3.3.15 ko:K03852 ko00430,map00430 - R05651 RC02903,RC02909 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_642459_1 1380390.JIAT01000011_gene2343 7.37e-129 385.0 COG1524@1|root,COG1524@2|Bacteria,2HH0Q@201174|Actinobacteria,4CRNQ@84995|Rubrobacteria 84995|Rubrobacteria S Mycobacterial 4 TMS phage holin, superfamily IV - - - - - - - - - - - - Phage_holin_4_2,Phosphodiest k59_900457_1 269796.Rru_A3329 1.88e-46 165.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2TQT3@28211|Alphaproteobacteria,2JQBS@204441|Rhodospirillales 204441|Rhodospirillales J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_534416_1 768671.ThimaDRAFT_3432 3.74e-112 336.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1S1KY@1236|Gammaproteobacteria,1X28H@135613|Chromatiales 135613|Chromatiales M Mycolic acid cyclopropane synthetase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_1423635_1 1089551.KE386572_gene1111 4.16e-48 169.0 COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,4BQDY@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G HpcH/HpaI aldolase/citrate lyase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_1423635_2 1177181.T9A_00657 2.98e-104 311.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1XIR9@135619|Oceanospirillales 135619|Oceanospirillales P Sulfurtransferase glpE - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_483506_1 561175.KB894093_gene3083 1.69e-15 80.9 COG1721@1|root,COG1721@2|Bacteria,2GK9A@201174|Actinobacteria,4EGZ7@85012|Streptosporangiales 201174|Actinobacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF11,DUF58 k59_273513_1 237368.SCABRO_01638 9.32e-56 188.0 COG2239@1|root,COG2239@2|Bacteria,2IYCZ@203682|Planctomycetes 203682|Planctomycetes P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_67837_1 1144275.COCOR_07943 1.26e-38 139.0 COG0454@1|root,COG0456@2|Bacteria,1RD40@1224|Proteobacteria,43EF3@68525|delta/epsilon subdivisions,2X0ID@28221|Deltaproteobacteria,2Z1N2@29|Myxococcales 28221|Deltaproteobacteria K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 k59_799421_1 96561.Dole_1227 4.45e-17 88.6 COG2199@1|root,COG5002@1|root,COG2199@2|Bacteria,COG5002@2|Bacteria,1R4NY@1224|Proteobacteria,43AEW@68525|delta/epsilon subdivisions 1224|Proteobacteria T Diguanylate cyclase with PAS PAC sensor - - - - - - - - - - - - GGDEF,PAS,PAS_3,PAS_9 k59_430072_1 1121430.JMLG01000005_gene762 1.1e-85 265.0 COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,260YV@186807|Peptococcaceae 186801|Clostridia C PFAM isocitrate isopropylmalate dehydrogenase icd - 1.1.1.41,1.1.1.83,1.1.1.93,4.1.1.73 ko:K00030,ko:K07246 ko00020,ko00630,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00650,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00215,R00709,R01751,R02545,R06180 RC00084,RC00105,RC00114,RC00594 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_378245_1 1195246.AGRI_00010 1.22e-118 360.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,4652J@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iUTI89_1310.UTI89_C0210 HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_907074_1 587753.EY04_17825 7.99e-71 226.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,1RPPD@1236|Gammaproteobacteria 1236|Gammaproteobacteria E the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia - - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_593233_1 443143.GM18_4033 1.98e-49 179.0 COG1729@1|root,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,42TQ9@68525|delta/epsilon subdivisions,2WR3B@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_1432077_1 1173024.KI912148_gene3523 5.28e-66 214.0 COG2403@1|root,COG2403@2|Bacteria,1G1FF@1117|Cyanobacteria 1117|Cyanobacteria S cyclic 2,3-diphosphoglycerate synthetase activity - - - - - - - - - - - - cobW k59_808159_1 1030157.AFMP01000015_gene3474 9.13e-23 97.1 28KNT@1|root,2ZA6Z@2|Bacteria,1R4VT@1224|Proteobacteria,2U2YA@28211|Alphaproteobacteria,2K4YW@204457|Sphingomonadales 1224|Proteobacteria S EthD domain - - - - - - - - - - - - EthD k59_808159_2 1128421.JAGA01000004_gene2704 1.24e-58 194.0 COG2124@1|root,COG2124@2|Bacteria 2|Bacteria Q cytochrome p450 - - - - - - - - - - - - p450 k59_76398_1 498211.CJA_3783 1e-63 213.0 COG4974@1|root,COG4974@2|Bacteria,1NY1A@1224|Proteobacteria,1RN33@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_749806_1 349124.Hhal_0886 2.23e-13 68.2 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1WXJF@135613|Chromatiales 135613|Chromatiales E HAD-superfamily subfamily IB hydrolase, TIGR01490 - - - - - - - - - - - - HAD k59_1322044_1 400682.PAC_15702060 9.73e-83 256.0 COG1546@1|root,2SATH@2759|Eukaryota,3AA0F@33154|Opisthokonta 33154|Opisthokonta S Competence-damaged protein - - - - - - - - - - - - CinA k59_1376603_1 1562701.BBOF01000081_gene249 2.38e-15 80.9 28MS5@1|root,2ZB0J@2|Bacteria,1PTV9@1224|Proteobacteria,2VMIH@28216|Betaproteobacteria,1KD2P@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_593258_1 1056820.KB900647_gene3002 1.44e-83 253.0 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,2PNAR@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J 3' exoribonuclease family, domain 2 rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_1116785_1 1333523.L593_06150 3.89e-06 51.2 COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,23WBW@183963|Halobacteria 183963|Halobacteria K COG0456 Acetyltransferases - - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_1116785_2 1298593.TOL_0544 7.64e-12 70.9 COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,1RMWB@1236|Gammaproteobacteria,1XKJR@135619|Oceanospirillales 135619|Oceanospirillales P COG2010 Cytochrome c, mono- and diheme variants - - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - Cytochrome_CBB3,FTR1 k59_228527_1 1159870.KB907784_gene2178 1.33e-61 196.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,3T1CP@506|Alcaligenaceae 28216|Betaproteobacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_652410_1 589865.DaAHT2_0312 2.94e-40 148.0 COG3572@1|root,COG3572@2|Bacteria,1QYIK@1224|Proteobacteria,43D5R@68525|delta/epsilon subdivisions,2X8CF@28221|Deltaproteobacteria,2MMVT@213118|Desulfobacterales 28221|Deltaproteobacteria H Glutamate-cysteine ligase family 2(GCS2) - - - - - - - - - - - - GCS2 k59_908011_1 343509.SG1495 6.65e-66 211.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system ttcA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_652427_1 754476.Q7A_304 3.85e-78 239.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria,45ZZE@72273|Thiotrichales 72273|Thiotrichales E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_809546_1 1121918.ARWE01000001_gene2379 1.09e-45 153.0 COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,42QMC@68525|delta/epsilon subdivisions,2WMDH@28221|Deltaproteobacteria 28221|Deltaproteobacteria I 3-oxoacid CoA-transferase scoA - 2.8.3.5 ko:K01028 ko00072,ko00280,ko00650,map00072,map00280,map00650 - R00410 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_908021_1 1121015.N789_07455 3.19e-38 150.0 COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1MVZZ@1224|Proteobacteria,1RN29@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box) 5'-GGA TG GA-3' malT GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0005975,GO:0006355,GO:0008150,GO:0008152,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030246,GO:0031323,GO:0031326,GO:0042802,GO:0044238,GO:0048031,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070492,GO:0071704,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 - ko:K03556 - - - - ko00000,ko03000 - - - AAA_16,GerE k59_1487162_1 330214.NIDE2468 8.77e-41 142.0 COG0511@1|root,COG0511@2|Bacteria,3J0PI@40117|Nitrospirae 40117|Nitrospirae I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl k59_1487162_2 1123276.KB893246_gene881 0.000601 41.2 COG0231@1|root,COG0231@2|Bacteria,4NDXA@976|Bacteroidetes,47MZS@768503|Cytophagia 976|Bacteroidetes J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_125644_1 1265756.AWZW01000008_gene1282 1.99e-151 442.0 COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2TSN4@28211|Alphaproteobacteria 28211|Alphaproteobacteria C succinate dehydrogenase fumarate reductase, flavoprotein subunit MA20_14860 - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1640085_1 511062.GU3_02120 7.98e-209 594.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1Y3U5@135624|Aeromonadales 135624|Aeromonadales NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB exeE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1640085_2 913325.N799_03900 2.55e-23 100.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1X345@135614|Xanthomonadales 135614|Xanthomonadales U General secretion pathway protein xpsF GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_1433446_2 991905.SL003B_0894 1.24e-32 123.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,4BPMZ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Zinc-binding dehydrogenase MA20_18095 - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_908037_1 2340.JV46_12870 3.97e-71 224.0 COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,1RY8Q@1236|Gammaproteobacteria,1JB29@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Helix-turn-helix domain - - - - - - - - - - - - HTH_17,PBP_like k59_700735_1 861299.J421_4537 3.99e-53 188.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZT9R@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Dipeptidyl peptidase IV (DPP IV) N-terminal region - - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 k59_333760_1 351348.Maqu_1008 5.15e-36 136.0 COG0642@1|root,COG2205@2|Bacteria,1MXH7@1224|Proteobacteria,1RQZW@1236|Gammaproteobacteria,464FX@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_333760_2 479434.Sthe_0182 6.52e-05 44.3 COG0745@1|root,COG0745@2|Bacteria,2G88F@200795|Chloroflexi 200795|Chloroflexi K Two component transcriptional regulator, winged helix family - - - - - - - - - - - - Response_reg,Trans_reg_C k59_1279462_1 1177154.Y5S_00629 1.28e-56 180.0 COG0610@1|root,COG0610@2|Bacteria,1R89U@1224|Proteobacteria,1RZRD@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Subunit R is required for both nuclease and ATPase activities, but not for modification - - - - - - - - - - - - - k59_125663_1 1121921.KB898709_gene140 5.62e-51 172.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,2PMWK@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P Rhodanese Homology Domain rhdA - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_388295_1 1042377.AFPJ01000010_gene1464 3.9e-73 245.0 COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,1RNU3@1236|Gammaproteobacteria,46676@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_750811_1 329726.AM1_5196 3.5e-05 49.3 COG0566@1|root,COG0566@2|Bacteria,1G1S0@1117|Cyanobacteria 1117|Cyanobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family rlmB GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_750811_2 643648.Slip_0854 7.97e-24 97.8 COG0194@1|root,COG0194@2|Bacteria,1TP0M@1239|Firmicutes,24HEX@186801|Clostridia,42JXS@68298|Syntrophomonadaceae 186801|Clostridia F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_959135_1 293227.XP_008717526.1 9.85e-07 55.5 2BGTP@1|root,2S1A6@2759|Eukaryota,39ZXN@33154|Opisthokonta,3P2DR@4751|Fungi,3QUWA@4890|Ascomycota,20G3R@147545|Eurotiomycetes,3MU6A@451870|Chaetothyriomycetidae 4751|Fungi S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1377538_1 555778.Hneap_1970 2.22e-76 247.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1WX7K@135613|Chromatiales 135613|Chromatiales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_1586586_1 419947.MRA_2601 2.3e-28 117.0 COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria,234BZ@1762|Mycobacteriaceae 201174|Actinobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_173488_1 1031711.RSPO_c01301 2.76e-120 374.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,1JZNT@119060|Burkholderiaceae 28216|Betaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1116838_1 1469245.JFBG01000027_gene1470 5.8e-141 413.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria 1224|Proteobacteria E ABC-Type Dipeptide Transport System Periplasmic Component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_652492_2 502025.Hoch_5785 1.47e-67 213.0 COG3271@1|root,COG3271@2|Bacteria,1RAD5@1224|Proteobacteria,42QWA@68525|delta/epsilon subdivisions,2WMVM@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - Peptidase_C39,Peptidase_C39_2 k59_9114_1 565045.NOR51B_447 0.000158 42.4 COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,1SCHG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0125 (RnfH) family rnfH - - ko:K09801 - - - - ko00000 - - - Ub-RnfH k59_9114_2 1026882.MAMP_00066 4.71e-38 134.0 COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,1SCTT@1236|Gammaproteobacteria,4619W@72273|Thiotrichales 72273|Thiotrichales J Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamE - - ko:K06186 - - - - ko00000,ko02000 1.B.33.1 - - SmpA_OmlA k59_9114_3 395493.BegalDRAFT_3511 1.81e-33 119.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,1S4H7@1236|Gammaproteobacteria,460PC@72273|Thiotrichales 72273|Thiotrichales K Belongs to the Fur family fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_594306_1 944481.JAFP01000001_gene1028 9.82e-29 112.0 COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,42RVP@68525|delta/epsilon subdivisions,2WNCX@28221|Deltaproteobacteria,2M6H3@213113|Desulfurellales 28221|Deltaproteobacteria S Appr-1'-p processing enzyme ymdB - - - - - - - - - - - Macro k59_594306_2 596152.DesU5LDRAFT_3388 8.27e-05 50.4 COG0755@1|root,COG0755@2|Bacteria,1RCCI@1224|Proteobacteria,42PVM@68525|delta/epsilon subdivisions,2WJ7I@28221|Deltaproteobacteria,2M9DN@213115|Desulfovibrionales 28221|Deltaproteobacteria O PFAM Cytochrome c assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_700753_1 565033.GACE_0100 1.33e-79 254.0 COG5557@1|root,arCOG02025@2157|Archaea,2XWFI@28890|Euryarchaeota,246T1@183980|Archaeoglobi 183980|Archaeoglobi C PFAM Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_700753_2 653733.Selin_2493 6.37e-43 152.0 COG0437@1|root,COG0437@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding ttrB - - ko:K08358 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Fer4_11,Fer4_3,Fer4_7 k59_959153_1 247634.GPB2148_546 3.08e-67 219.0 COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,1S01Y@1236|Gammaproteobacteria,1J5XZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T PAS fold - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_77860_1 880073.Calab_1549 6.04e-71 240.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2NQEH@2323|unclassified Bacteria 2|Bacteria M Tricorn protease C1 domain - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ k59_493689_1 742159.HMPREF0004_0006 6.62e-21 91.7 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2VXA4@28216|Betaproteobacteria 28216|Betaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_652518_1 1123290.AUDQ01000026_gene3149 1.73e-05 48.9 COG0596@1|root,COG0596@2|Bacteria,1TS4C@1239|Firmicutes,4HB6G@91061|Bacilli,26EQN@186818|Planococcaceae 91061|Bacilli S Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) menH GO:0003674,GO:0003824,GO:0016787 4.2.99.20 ko:K08680 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08166 RC02148,RC02475 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_652518_2 1173028.ANKO01000075_gene2980 5.62e-66 209.0 COG0447@1|root,COG0447@2|Bacteria,1G10D@1117|Cyanobacteria,1H70Q@1150|Oscillatoriales 1117|Cyanobacteria H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) menB - 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 - - iJN678.menB ECH_1 k59_1640165_1 1521187.JPIM01000242_gene2870 3.64e-38 140.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2G816@200795|Chloroflexi 200795|Chloroflexi L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_1279527_1 1384054.N790_14350 8.87e-05 46.6 COG0845@1|root,COG0845@2|Bacteria,1MV1T@1224|Proteobacteria,1RQTS@1236|Gammaproteobacteria,1X80N@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3,HlyD_D23 k59_1279527_2 713587.THITH_13285 6.75e-156 452.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,1WXVR@135613|Chromatiales 135613|Chromatiales S Flavocytochrome c sulphide dehydrogenase, flavin-binding - - 1.8.2.3 ko:K17229 ko00920,ko01120,map00920,map01120 - R09499 - ko00000,ko00001,ko01000 - - - FCSD-flav_bind,Pyr_redox_2 k59_855828_1 768706.Desor_4487 9.92e-30 120.0 COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,26070@186807|Peptococcaceae 186801|Clostridia J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17,6.1.1.24 ko:K01885,ko:K09698 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R03651,R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_228614_1 1283300.ATXB01000001_gene2068 3.34e-82 254.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1S032@1236|Gammaproteobacteria,1XEKP@135618|Methylococcales 135618|Methylococcales S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_1586623_1 330214.NIDE2737 6.61e-121 363.0 COG0465@1|root,COG0465@2|Bacteria,3J0AG@40117|Nitrospirae 40117|Nitrospirae D Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_652568_1 468059.AUHA01000002_gene563 4.88e-48 172.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IR3J@117747|Sphingobacteriia 976|Bacteroidetes K Tetratricopeptide repeat - - - - - - - - - - - - ANAPC3,Guanylate_cyc,HTH_18,TPR_8 k59_1166422_1 4577.GRMZM2G062613_P01 0.00013 50.1 COG2133@1|root,2QQKP@2759|Eukaryota,37JS2@33090|Viridiplantae,3GFS6@35493|Streptophyta,3KRCV@4447|Liliopsida,3IFB1@38820|Poales 35493|Streptophyta G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH k59_9160_1 207954.MED92_07371 1.45e-89 271.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1XHAN@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_1116884_1 402626.Rpic_1928 2.72e-105 321.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2VJ6H@28216|Betaproteobacteria,1K0GT@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor pyrD - 1.3.5.2 ko:K00254 ko00240,ko01100,map00240,map01100 M00051 R01868 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_1116884_2 580332.Slit_0463 2.67e-80 245.0 COG1187@1|root,COG1187@2|Bacteria,1MXQE@1224|Proteobacteria,2VI7P@28216|Betaproteobacteria,44VGU@713636|Nitrosomonadales 28216|Betaproteobacteria J S4 RNA-binding domain rluF - 5.4.99.21 ko:K06182 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_959194_1 502025.Hoch_0368 1.72e-52 181.0 COG0500@1|root,COG2226@2|Bacteria,1NDFZ@1224|Proteobacteria,42R89@68525|delta/epsilon subdivisions,2X5PC@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q UbiE COQ5 methyltransferase - - - - - - - - - - - - Methyltransf_25 k59_1116885_1 870187.Thini_0421 1.54e-88 274.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,4606R@72273|Thiotrichales 72273|Thiotrichales L ATPase (AAA - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_388362_1 404589.Anae109_0854 2.07e-80 269.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJBR@28221|Deltaproteobacteria,2YUAD@29|Myxococcales 28221|Deltaproteobacteria E Glutamate synthase gltB1 - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_809709_1 572480.Arnit_1630 2.33e-14 75.1 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,42NJV@68525|delta/epsilon subdivisions,2YRBC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_333841_1 525368.HMPREF0591_2366 3.95e-51 182.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,233NX@1762|Mycobacteriaceae 201174|Actinobacteria C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 k59_228643_2 411471.SUBVAR_04865 1.11e-32 120.0 COG1225@1|root,COG1225@2|Bacteria,1V3N5@1239|Firmicutes,24HP8@186801|Clostridia,3WIK4@541000|Ruminococcaceae 186801|Clostridia O Redoxin bcp - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_438540_1 1347392.CCEZ01000023_gene809 0.000118 44.3 COG0689@1|root,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,25E5P@186801|Clostridia,36DSU@31979|Clostridiaceae 186801|Clostridia J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56,3.6.1.66 ko:K00989,ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000,ko03016 - - - Ham1p_like,RNase_PH,RNase_PH_C k59_238910_1 47763.JNZA01000027_gene5864 2.84e-34 135.0 COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria 201174|Actinobacteria Q N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_3,Urease_alpha k59_969565_1 1469245.JFBG01000038_gene1816 1.24e-28 115.0 2DNW4@1|root,32ZGA@2|Bacteria,1N7ZK@1224|Proteobacteria,1SDPA@1236|Gammaproteobacteria,1X1PN@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF3306) - - - - - - - - - - - - DUF3306 k59_1654582_2 1144275.COCOR_07358 7.87e-60 198.0 COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,42Q9D@68525|delta/epsilon subdivisions,2WK21@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 k59_293138_1 653733.Selin_0159 3.49e-72 245.0 COG0458@1|root,COG0458@2|Bacteria 2|Bacteria F carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS k59_1331649_1 1279038.KB907339_gene1436 1.05e-15 79.0 COG2271@1|root,COG2271@2|Bacteria,1NJTU@1224|Proteobacteria,2TUBJ@28211|Alphaproteobacteria,2JPTM@204441|Rhodospirillales 204441|Rhodospirillales G COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_1331649_2 411468.CLOSCI_03798 9.73e-11 62.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia 186801|Clostridia P Belongs to the ABC transporter superfamily oppD - - ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_1076686_1 83406.HDN1F_02800 1.56e-13 76.3 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1J6H5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M silverDB - - - - - - - - - - - - DUF11,RHS,RHS_repeat k59_760863_1 1229909.NSED_09020 1.96e-65 208.0 arCOG10599@1|root,arCOG10599@2157|Archaea 2157|Archaea C copper ion binding - - - - - - - - - - - - - k59_1237404_1 78245.Xaut_5043 2.79e-143 421.0 COG1884@1|root,COG1884@2|Bacteria,1NQI2@1224|Proteobacteria,2UP9V@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Methylmalonyl-CoA mutase - GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016853,GO:0016866,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_1022123_1 404589.Anae109_2569 2.57e-35 144.0 COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,42UWC@68525|delta/epsilon subdivisions,2X5C3@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM V-type ATPase 116 kDa - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - - k59_397125_1 1201288.M900_2517 3.39e-23 97.4 COG1651@1|root,COG1651@2|Bacteria,1MVS2@1224|Proteobacteria,42UNJ@68525|delta/epsilon subdivisions 1224|Proteobacteria O Thioredoxin - - - - - - - - - - - - Thioredoxin_4 k59_1654622_2 1497679.EP56_05680 7.58e-06 50.4 2EI4V@1|root,33BW7@2|Bacteria,1VKQH@1239|Firmicutes,4HRPN@91061|Bacilli,26M00@186820|Listeriaceae 91061|Bacilli S Protein of unknwon function (DUF3310) - - - - - - - - - - - - DUF3310 k59_710982_1 1510531.JQJJ01000010_gene1826 6.67e-38 135.0 COG0684@1|root,COG0684@2|Bacteria,1MUWV@1224|Proteobacteria,2TU1X@28211|Alphaproteobacteria,3JUHY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H Aldolase/RraA - - - - - - - - - - - - RraA-like k59_604247_1 394221.Mmar10_0350 7.01e-67 221.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,43ZFF@69657|Hyphomonadaceae 28211|Alphaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster MA20_01050 - 1.17.1.10 ko:K15022 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3 k59_604247_2 394221.Mmar10_0351 9.84e-44 157.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,43Z43@69657|Hyphomonadaceae 28211|Alphaproteobacteria C pyruvate flavodoxin ferredoxin oxidoreductase MA20_01045 - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1128853_1 1156937.MFUM_750016 3.6e-40 149.0 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,46YW3@74201|Verrucomicrobia,37G5X@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia S AAA domain gntK - - ko:K07028 - - - - ko00000 - - - AAA_33 k59_1596623_1 981223.AIED01000039_gene535 0.000337 42.4 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,3NJGF@468|Moraxellaceae 1236|Gammaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_1293820_1 1166948.JPZL01000002_gene980 1.39e-120 372.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1XHCH@135619|Oceanospirillales 135619|Oceanospirillales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1445676_1 1168065.DOK_07494 4.88e-52 175.0 COG0183@1|root,COG0183@2|Bacteria,1PSXC@1224|Proteobacteria,1RQDP@1236|Gammaproteobacteria,1J54E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the thiolase family - - - - - - - - - - - - Thiolase_C k59_823975_1 1463864.JOGO01000025_gene2818 7.76e-25 108.0 COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria 201174|Actinobacteria IQ Peptidase S15 - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_920247_2 264951.V5FTH9 2.65e-06 53.9 29C2N@1|root,2RJ67@2759|Eukaryota,38NVQ@33154|Opisthokonta,3PQRG@4751|Fungi,3RA7X@4890|Ascomycota,20NE4@147545|Eurotiomycetes,3SDAF@5042|Eurotiales 4751|Fungi S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_920247_3 331869.BAL199_27975 3.56e-75 240.0 COG2807@1|root,COG2807@2|Bacteria,1QUCZ@1224|Proteobacteria,2TY3D@28211|Alphaproteobacteria,4BTDY@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1654663_1 1121878.AUGL01000018_gene16 1.19e-28 114.0 COG1651@1|root,COG1651@2|Bacteria,1MVAC@1224|Proteobacteria,1S34E@1236|Gammaproteobacteria 1236|Gammaproteobacteria O COG1651 Protein-disulfide isomerase - - - - - - - - - - - - Thioredoxin_4 k59_551917_1 246197.MXAN_3431 5.76e-20 94.0 COG1538@1|root,COG1538@2|Bacteria,1MWB0@1224|Proteobacteria,42UCF@68525|delta/epsilon subdivisions,2WREI@28221|Deltaproteobacteria 28221|Deltaproteobacteria MU Outer membrane efflux protein - - - ko:K15725 - - - - ko00000,ko02000 1.B.17.2.2 - - OEP k59_1331685_2 1123401.JHYQ01000001_gene1936 4.1e-27 108.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,4632W@72273|Thiotrichales 72273|Thiotrichales S Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,Hydrolase_4 k59_1022154_1 1121921.KB898709_gene315 1.07e-58 191.0 COG0834@1|root,COG0834@2|Bacteria,1MWDK@1224|Proteobacteria,1RZ89@1236|Gammaproteobacteria 1236|Gammaproteobacteria ET belongs to the bacterial solute-binding protein 3 family fliY - - ko:K02030,ko:K02424,ko:K10036 ko02010,map02010 M00227,M00234,M00236 - - ko00000,ko00001,ko00002,ko02000,ko02035 3.A.1.3,3.A.1.3.10,3.A.1.3.14,3.A.1.3.2 - - SBP_bac_3 k59_920255_1 525904.Tter_0632 4.22e-34 135.0 COG0699@1|root,COG0699@2|Bacteria,2NQN2@2323|unclassified Bacteria 2|Bacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_138270_1 983545.Glaag_1324 2.58e-48 164.0 COG1842@1|root,COG1842@2|Bacteria,1NC7S@1224|Proteobacteria,1RS0G@1236|Gammaproteobacteria,464K6@72275|Alteromonadaceae 1236|Gammaproteobacteria KT COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription pspA GO:0003674,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0008289,GO:0009266,GO:0009271,GO:0009408,GO:0009605,GO:0009607,GO:0009615,GO:0009628,GO:0009889,GO:0009898,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019897,GO:0019898,GO:0031234,GO:0031323,GO:0031326,GO:0042802,GO:0043167,GO:0043168,GO:0043207,GO:0043433,GO:0044092,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0050896,GO:0051090,GO:0051171,GO:0051252,GO:0051704,GO:0051707,GO:0060187,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0098552,GO:0098562,GO:0098586,GO:1903506,GO:2000112,GO:2001141 - ko:K03969 - - - - ko00000 - - - PspA_IM30 k59_182094_1 395493.BegalDRAFT_2354 9.25e-07 57.4 COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,1RMDQ@1236|Gammaproteobacteria,462J7@72273|Thiotrichales 1236|Gammaproteobacteria T Protein tyrosine kinase - - - - - - - - - - - - DUF1566,Pkinase k59_508033_1 518766.Rmar_0342 2.88e-118 357.0 COG0209@1|root,COG0209@2|Bacteria,4NEHQ@976|Bacteroidetes,1FJVJ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrd - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_1596646_2 1122939.ATUD01000008_gene2523 1.86e-07 52.0 COG3288@1|root,COG3288@2|Bacteria,2I2FZ@201174|Actinobacteria,4CPAE@84995|Rubrobacteria 84995|Rubrobacteria C Alanine dehydrogenase/PNT, N-terminal domain - - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_711020_1 1005999.GLGR_3237 7.5e-54 191.0 COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,1RPJ6@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Cellulose synthase bcsA GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016020,GO:0016051,GO:0030243,GO:0030244,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0051273,GO:0051274,GO:0071704,GO:0071944,GO:0090540,GO:1901576 2.4.1.12 ko:K00694 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - Cellulose_synt,Glyco_hydro_17,Glyco_tranf_2_3,Glycos_transf_2,PilZ k59_91871_1 1267005.KB911257_gene1166 1.58e-75 238.0 COG1679@1|root,COG1679@2|Bacteria,1NFH4@1224|Proteobacteria,2TTR6@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF521) - - - ko:K09123 - - - - ko00000 - - - DUF521 k59_1022173_1 1131553.JIBI01000009_gene1209 5.86e-83 262.0 COG3111@1|root,COG3111@2|Bacteria,1MU8B@1224|Proteobacteria,2VSNU@28216|Betaproteobacteria,372PW@32003|Nitrosomonadales 28216|Betaproteobacteria S short chain amide porin - - - - - - - - - - - - Porin_O_P k59_760920_1 381764.Fnod_0879 3.26e-13 75.1 COG2203@1|root,COG5000@1|root,COG2203@2|Bacteria,COG5000@2|Bacteria,2GCCB@200918|Thermotogae 200918|Thermotogae T Histidine kinase - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_4 k59_969662_1 1411123.JQNH01000001_gene1248 5.35e-06 48.1 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria 28211|Alphaproteobacteria C FAD linked oxidase domain protein - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_969662_2 883080.HMPREF9697_01318 3.34e-49 169.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,3JRV2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Aminotransferase class-V MA20_43180 - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_1445726_1 338963.Pcar_1849 2.07e-05 48.1 COG3216@1|root,COG3216@2|Bacteria,1QEG2@1224|Proteobacteria,42VUY@68525|delta/epsilon subdivisions,2WRD1@28221|Deltaproteobacteria,43SKM@69541|Desulfuromonadales 28221|Deltaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2062) - - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_451304_1 1075090.GOAMR_58_00220 1.91e-20 94.4 COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,4GCZM@85026|Gordoniaceae 201174|Actinobacteria C Cytochrome P450 - - - - - - - - - - - - p450 k59_345324_1 1116472.MGMO_71c00040 2.72e-97 302.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1XEBM@135618|Methylococcales 135618|Methylococcales O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_866028_1 930166.CD58_17850 2.09e-32 123.0 COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,1RYJT@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - ko:K03566 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_1654733_2 224325.AF_0838 4.82e-06 52.4 COG1970@1|root,arCOG01959@2157|Archaea,2XV1N@28890|Euryarchaeota,2463U@183980|Archaeoglobi 183980|Archaeoglobi P PFAM TrkA-N domain - - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_824046_1 316056.RPC_3482 3.87e-97 294.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria,3JTM1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I acyl-CoA dehydrogenase MA20_31035 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_293237_1 1134474.O59_000465 1.25e-25 110.0 28P4Q@1|root,2ZBZV@2|Bacteria,1RA48@1224|Proteobacteria,1S347@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1237512_1 323261.Noc_0312 9.4e-71 231.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WXAR@135613|Chromatiales 135613|Chromatiales NU TIGRFAM type IV-A pilus assembly ATPase PilB - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_91904_1 748247.AZKH_0868 2.15e-48 172.0 COG2206@1|root,COG2206@2|Bacteria,1R3VR@1224|Proteobacteria,2VMY5@28216|Betaproteobacteria,2KVPZ@206389|Rhodocyclales 206389|Rhodocyclales T Domain of unknown function (DUF3391) - - - - - - - - - - - - DUF3391,HD_5 k59_920305_2 1519464.HY22_11175 3.73e-11 63.2 COG1136@1|root,COG1136@2|Bacteria,1FEY9@1090|Chlorobi 1090|Chlorobi V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1331731_1 1535287.JP74_17730 1.44e-13 75.5 COG1960@1|root,COG1960@2|Bacteria,1N05C@1224|Proteobacteria,2TT9T@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_345337_1 228410.NE0329 9.8e-119 349.0 COG0535@1|root,COG0535@2|Bacteria,1MXM1@1224|Proteobacteria,2VNRX@28216|Betaproteobacteria,371QM@32003|Nitrosomonadales 28216|Betaproteobacteria S Domain of unknown function (DUF3463) hpnH - - - - - - - - - - - DUF3463,Fer4_14,Radical_SAM k59_711057_1 1528106.JRJE01000020_gene2189 2.95e-51 177.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2TSQI@28211|Alphaproteobacteria,2JPPT@204441|Rhodospirillales 204441|Rhodospirillales E FAD dependent oxidoreductase - - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_712113_1 861299.J421_1695 5.75e-23 103.0 COG0457@1|root,COG0457@2|Bacteria,1ZV58@142182|Gemmatimonadetes 142182|Gemmatimonadetes S chaperone-mediated protein folding - - - - - - - - - - - - - k59_93132_1 436308.Nmar_1605 6.54e-76 238.0 COG2262@1|root,arCOG00353@2157|Archaea,41SD4@651137|Thaumarchaeota 651137|Thaumarchaeota S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_1130194_1 400682.PAC_15703455 5.63e-78 254.0 COG1331@1|root,KOG2244@2759|Eukaryota 2759|Eukaryota O spermatogenesis - - - - - - - - - - - - Glyco_hydro_9,Thioredox_DsbH k59_346542_1 1121405.dsmv_3409 3.91e-86 265.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,42MCP@68525|delta/epsilon subdivisions,2WJDS@28221|Deltaproteobacteria,2MHYY@213118|Desulfobacterales 28221|Deltaproteobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - iAF987.Gmet_0409 Glycos_transf_4,MraY_sig1 k59_1502923_1 589924.Ferp_1614 7.34e-15 75.1 arCOG05636@1|root,arCOG05636@2157|Archaea,2Y231@28890|Euryarchaeota,246ID@183980|Archaeoglobi 183980|Archaeoglobi C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_867042_1 1038859.AXAU01000056_gene98 3.85e-166 473.0 COG4948@1|root,COG4948@2|Bacteria,1R9J6@1224|Proteobacteria,2TVSM@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_1295403_1 290397.Adeh_1565 4.85e-45 167.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2YYYV@29|Myxococcales 28221|Deltaproteobacteria P transporter of a GTP-driven Fe(2 ) uptake system - - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_1537965_1 439235.Dalk_1753 2.26e-58 190.0 COG0300@1|root,COG0623@1|root,COG0300@2|Bacteria,COG0623@2|Bacteria,1R090@1224|Proteobacteria,43CRU@68525|delta/epsilon subdivisions,2X7ZF@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_1537965_2 349124.Hhal_0727 8.58e-11 63.2 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1WWNU@135613|Chromatiales 135613|Chromatiales E PFAM Aminotransferase class-III argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1454716_2 1353531.AZNX01000010_gene1069 3.78e-49 172.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_192020_1 545276.KB898735_gene1283 9.14e-27 115.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_770812_1 317025.Tcr_0935 9.82e-16 76.3 COG0598@1|root,COG0598@2|Bacteria,1MW8W@1224|Proteobacteria,1RRTZ@1236|Gammaproteobacteria,460RS@72273|Thiotrichales 72273|Thiotrichales P CorA-like Mg2+ transporter protein - - - ko:K16074 - - - - ko00000,ko02000 1.A.35.4 - - CorA k59_770812_2 335543.Sfum_2864 7.33e-88 266.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QXM@68525|delta/epsilon subdivisions,2WMZI@28221|Deltaproteobacteria,2MRM3@213462|Syntrophobacterales 28221|Deltaproteobacteria O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_1032460_2 1493510.A0A0E3G6C9_9CAUD 6.2e-51 170.0 4QC4P@10239|Viruses,4QR27@28883|Caudovirales 28883|Caudovirales S aldehyde-lyase activity - - - - - - - - - - - - - k59_1669386_2 1121940.AUDZ01000018_gene454 3.12e-36 135.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XIXB@135619|Oceanospirillales 135619|Oceanospirillales T With GlrK is part of a two-component signal transduction system regulating glmY - - - ko:K07715 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_103177_1 414684.RC1_0298 2.1e-69 235.0 COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,1MXH9@1224|Proteobacteria,2TUMC@28211|Alphaproteobacteria,2JRGB@204441|Rhodospirillales 204441|Rhodospirillales S Uncharacterised conserved protein (DUF2156) - - 2.3.2.3 ko:K07027,ko:K14205 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 - - ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 2.A.1.3.37,4.D.2 - - DUF2156,LPG_synthase_TM k59_1032472_1 1469245.JFBG01000040_gene1718 6.88e-15 73.9 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,1WWKS@135613|Chromatiales 135613|Chromatiales M Involved in formation and maintenance of cell shape - - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_1032472_2 754476.Q7A_2836 5.68e-35 128.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,4602K@72273|Thiotrichales 72273|Thiotrichales D TIGRFAM Cell shape determining protein MreB Mrl - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_304608_1 1333856.L686_05350 1.14e-20 85.9 COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,1S4GX@1236|Gammaproteobacteria,1Z2VP@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria U TonB system transport protein ExbD exbD - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_1669407_1 234267.Acid_5986 2.18e-34 128.0 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator psrA - - - - - - - - - - - TetR_N k59_1669407_2 1173025.GEI7407_0458 2.5e-12 68.2 COG1972@1|root,COG1972@2|Bacteria,1G3CA@1117|Cyanobacteria,1H7FT@1150|Oscillatoriales 1117|Cyanobacteria F PFAM Na dependent nucleoside transporter - - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_614158_1 321332.CYB_2656 9.43e-96 291.0 COG0604@1|root,COG0604@2|Bacteria,1FZW8@1117|Cyanobacteria,1GZNP@1129|Synechococcus 1117|Cyanobacteria C Oxidoreductase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N_2 k59_931659_2 1095769.CAHF01000005_gene1644 1.52e-45 151.0 2D8VC@1|root,32TS1@2|Bacteria,1MZWT@1224|Proteobacteria,2W3HS@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1032483_1 1209072.ALBT01000052_gene608 1.55e-61 211.0 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,1RMAF@1236|Gammaproteobacteria,1FGAA@10|Cellvibrio 1236|Gammaproteobacteria G FGGY family of carbohydrate kinases, N-terminal domain - - 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_461921_1 765912.Thimo_0934 2.23e-13 69.7 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1WX6T@135613|Chromatiales 135613|Chromatiales I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_461921_2 765913.ThidrDRAFT_0864 7.2e-62 206.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1WWPM@135613|Chromatiales 135613|Chromatiales D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_356599_1 443143.GM18_2433 5.1e-25 102.0 COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,42R2X@68525|delta/epsilon subdivisions,2WMU1@28221|Deltaproteobacteria,43UHH@69541|Desulfuromonadales 28221|Deltaproteobacteria NU Type II secretion system (T2SS), protein F - - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF k59_931667_1 1125863.JAFN01000001_gene3569 1.73e-59 193.0 2DREW@1|root,33BF6@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_931667_2 443143.GM18_1107 4.07e-54 183.0 COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,42NBM@68525|delta/epsilon subdivisions,2WKTG@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PFAM Cytochrome c oxidase, subunit I - - 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - COX1 k59_1184502_1 1207063.P24_18147 4.12e-25 100.0 COG4454@1|root,COG4454@2|Bacteria,1RIJK@1224|Proteobacteria,2UIYE@28211|Alphaproteobacteria,2JWVE@204441|Rhodospirillales 204441|Rhodospirillales P Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - - k59_1669443_1 28072.Nos7524_1841 1.09e-78 244.0 COG0167@1|root,COG0167@2|Bacteria,1G2B6@1117|Cyanobacteria,1HM34@1161|Nostocales 1117|Cyanobacteria F Catalyzes the conversion of dihydroorotate to orotate - - 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_562346_1 608538.HTH_0153 1.03e-74 242.0 COG0843@1|root,COG0843@2|Bacteria 2|Bacteria C heme-copper terminal oxidase activity cbaA - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_614186_3 1122222.AXWR01000035_gene215 1.17e-09 59.7 COG1449@1|root,COG1501@1|root,COG1449@2|Bacteria,COG1501@2|Bacteria,1WJCV@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Glycosyl hydrolase family 57 - - - - - - - - - - - - Glucodextran_C,Glyco_hydro_57 k59_192096_1 1198232.CYCME_2050 4.19e-18 79.0 COG0720@1|root,COG0720@2|Bacteria,1RKBW@1224|Proteobacteria,1S7FX@1236|Gammaproteobacteria 1236|Gammaproteobacteria H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_192096_2 870187.Thini_0200 2.54e-14 75.5 COG2143@1|root,COG2143@2|Bacteria,1QDKY@1224|Proteobacteria,1RZ7R@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Thioredoxin-like domain - - - - - - - - - - - - Thioredoxin_2 k59_1340783_1 1224136.AMFN01000002_gene1085 0.000223 49.3 COG1649@1|root,COG1649@2|Bacteria,1N99Y@1224|Proteobacteria,1RSIV@1236|Gammaproteobacteria,28374@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria S Glycosyl hydrolase-like 10 yddW - - - - - - - - - - - GHL10 k59_103250_2 1500893.JQNB01000001_gene3480 1.4e-18 85.5 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1X4MX@135614|Xanthomonadales 135614|Xanthomonadales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_148490_1 436308.Nmar_0409 2.01e-112 335.0 COG0579@1|root,arCOG00754@2157|Archaea,41SXA@651137|Thaumarchaeota 651137|Thaumarchaeota S FAD dependent oxidoreductase - - - ko:K15736 - - - - ko00000,ko01000 - - - DAO k59_1140231_1 1120953.AUBH01000002_gene1456 1.69e-26 104.0 COG4659@1|root,COG4659@2|Bacteria,1R6FE@1224|Proteobacteria,1RYZ7@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport - - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_1140231_2 1239962.C943_00088 2.47e-20 86.7 COG4660@1|root,COG4660@2|Bacteria,4NHHP@976|Bacteroidetes 976|Bacteroidetes C Part of a membrane complex involved in electron transport rnfE - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_1032541_1 1286106.MPL1_03860 6.56e-40 142.0 COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,460VI@72273|Thiotrichales 72273|Thiotrichales D Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity zapD - - ko:K18778 - - - - ko00000,ko03036 - - - ZapD k59_931720_1 880072.Desac_0495 3.28e-22 89.7 2F79F@1|root,33ZQP@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_614213_1 1094980.Mpsy_1741 1.63e-34 128.0 COG1045@1|root,arCOG01847@2157|Archaea,2XUZJ@28890|Euryarchaeota,2N9VY@224756|Methanomicrobia 224756|Methanomicrobia E TIGRFAM serine O-acetyltransferase - - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - FeS_assembly_P,Hexapep,SATase_N k59_1140253_1 1463917.JODC01000002_gene850 6.19e-19 90.9 COG1262@1|root,COG1262@2|Bacteria,2GK9Q@201174|Actinobacteria 201174|Actinobacteria KLT Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma- L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine - - - - - - - - - - - - FGE-sulfatase k59_721564_1 1268068.PG5_14520 5.25e-70 222.0 COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,1RSP4@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Dehydrogenase hdhA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0008206,GO:0008709,GO:0009056,GO:0009987,GO:0016043,GO:0016054,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0030573,GO:0032787,GO:0033764,GO:0042802,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072329,GO:1901360,GO:1901575,GO:1901615 1.1.1.159 ko:K00076 ko00121,map00121 - - - ko00000,ko00001,ko01000 - - - adh_short,adh_short_C2 k59_462004_1 1128421.JAGA01000001_gene2151 1.14e-31 124.0 COG1957@1|root,COG1957@2|Bacteria,2NPG1@2323|unclassified Bacteria 2|Bacteria F Inosine-uridine preferring nucleoside hydrolase iunH - 3.2.2.1 ko:K01239,ko:K01250 ko00230,ko00760,ko01100,map00230,map00760,map01100 - R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 - - - IU_nuc_hydro k59_770915_1 1123230.ARQJ01000026_gene1941 1.57e-20 92.8 COG5146@1|root,COG5146@2|Bacteria,1V2R2@1239|Firmicutes,4HG04@91061|Bacilli,4GXEU@90964|Staphylococcaceae 91061|Bacilli F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaW - 2.7.1.33 ko:K09680 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Fumble k59_770917_1 582515.KR51_00028590 1.97e-08 61.2 COG1404@1|root,COG2755@1|root,COG1404@2|Bacteria,COG2755@2|Bacteria,1G0DF@1117|Cyanobacteria 1117|Cyanobacteria O Subtilase family - - - - - - - - - - - - HemolysinCabind,Peptidase_S8 k59_1186270_2 867903.ThesuDRAFT_01678 2.27e-32 122.0 COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia,3WCFH@538999|Clostridiales incertae sedis 186801|Clostridia J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_463890_1 298655.KI912266_gene4041 8.67e-45 159.0 COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria 201174|Actinobacteria S Pfam Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1606102_1 1246459.KB898370_gene1039 7.17e-31 114.0 COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2UBTA@28211|Alphaproteobacteria,4BEUA@82115|Rhizobiaceae 28211|Alphaproteobacteria S protein conserved in bacteria MA20_39715 - - - - - - - - - - - DUF1178 k59_1606102_2 483219.LILAB_12355 6.52e-31 114.0 28R6X@1|root,2ZDKX@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_409327_1 595537.Varpa_0959 2.28e-49 166.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria,4A9QE@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_463913_1 414684.RC1_0705 8.85e-113 337.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2TQUS@28211|Alphaproteobacteria,2JPP6@204441|Rhodospirillales 204441|Rhodospirillales J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,UPF0004 k59_20023_1 472759.Nhal_0350 6.81e-40 138.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1WX3P@135613|Chromatiales 135613|Chromatiales E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG k59_1456605_1 401053.AciPR4_3390 1.08e-49 177.0 COG0449@1|root,COG0449@2|Bacteria,3Y2NE@57723|Acidobacteria,2JI69@204432|Acidobacteriia 204432|Acidobacteriia M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_1142534_1 330214.NIDE4105 2.91e-116 345.0 COG0215@1|root,COG0215@2|Bacteria,3J0CM@40117|Nitrospirae 40117|Nitrospirae J DALR_2 cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_564178_1 1229909.NSED_02635 2.19e-62 200.0 COG0784@1|root,arCOG02391@2157|Archaea 2157|Archaea T response regulator, receiver - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_194204_1 1205683.CAKR01000004_gene2237 4.58e-19 87.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,41E7N@629|Yersinia 1236|Gammaproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0750,iAPECO1_1312.APECO1_1338,iB21_1397.B21_00692,iBWG_1329.BWG_0602,iECBD_1354.ECBD_2917,iECB_1328.ECB_00703,iECDH10B_1368.ECDH10B_0817,iECDH1ME8569_1439.ECDH1ME8569_0703,iECD_1391.ECD_00703,iECED1_1282.ECED1_0711,iECOK1_1307.ECOK1_0750,iECP_1309.ECP_0761,iECS88_1305.ECS88_0766,iECSP_1301.ECSP_0802,iECs_1301.ECs0778,iETEC_1333.ETEC_0754,iEcDH1_1363.EcDH1_2892,iEcolC_1368.EcolC_2912,iJN746.PP_1231,iJO1366.b0750,iJR904.b0750,iUMN146_1321.UM146_13905,iUTI89_1310.UTI89_C0747,iY75_1357.Y75_RS03905,iZ_1308.Z0919 NadA k59_194204_2 1033802.SSPSH_001710 6.12e-08 56.6 COG0790@1|root,COG3807@1|root,COG0790@2|Bacteria,COG3807@2|Bacteria,1MWPA@1224|Proteobacteria,1RPI3@1236|Gammaproteobacteria 1236|Gammaproteobacteria O COG0790 FOG TPR repeat, SEL1 subfamily - - - ko:K07126 - - - - ko00000 - - - SH3_3,Sel1 k59_194224_1 1396858.Q666_15445 2.06e-26 103.0 COG1664@1|root,COG1664@2|Bacteria,1PDPX@1224|Proteobacteria,1S9XY@1236|Gammaproteobacteria,46885@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG1664 Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_980010_1 1121921.KB898706_gene3207 6.43e-30 116.0 COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,1RP0S@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Catalyzes the sodium-dependent transport of glutamate - - - - - - - - - - - - Glt_symporter k59_1090103_2 666685.R2APBS1_3507 4.53e-30 115.0 COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,1SDNN@1236|Gammaproteobacteria,1X44C@135614|Xanthomonadales 135614|Xanthomonadales S Las17-binding protein actin regulator - - - - - - - - - - - - Ysc84 k59_877784_1 1168065.DOK_12346 4.36e-28 116.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,1RPFW@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_723410_1 1502852.FG94_00869 1.57e-50 181.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,475C1@75682|Oxalobacteraceae 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - DUF2222,EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,PAS_9 k59_306547_1 1221522.B723_02585 5.1e-29 111.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,1YMCD@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_306547_2 1335757.SPICUR_02840 3.16e-55 176.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,1S5VU@1236|Gammaproteobacteria,1WYA2@135613|Chromatiales 135613|Chromatiales J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_1549076_1 1007105.PT7_3036 1.3e-26 112.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria,3T5HE@506|Alcaligenaceae 28216|Betaproteobacteria I Carboxyl transferase domain pccB - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_194251_1 485913.Krac_11684 8.66e-42 145.0 COG1216@1|root,COG1216@2|Bacteria,2G69V@200795|Chloroflexi 200795|Chloroflexi S PFAM Glycosyl transferase family 2 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 k59_366488_1 935261.JAGL01000072_gene248 8.47e-88 268.0 COG3639@1|root,COG3639@2|Bacteria,1MUD6@1224|Proteobacteria,2TTVG@28211|Alphaproteobacteria,43KG2@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Binding-protein-dependent transport system inner membrane component phnE_2 - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 k59_366488_2 1089552.KI911559_gene3140 4.26e-65 209.0 COG3638@1|root,COG3638@2|Bacteria,1MVE9@1224|Proteobacteria,2TRR3@28211|Alphaproteobacteria,2JQEH@204441|Rhodospirillales 204441|Rhodospirillales P Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system - - 3.6.3.28 ko:K02041 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.9 - - ABC_tran k59_209648_2 1163408.UU9_04594 1.78e-39 147.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1X2YR@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_888882_1 1219080.VEZ01S_08_00570 7.03e-99 305.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,1RN2U@1236|Gammaproteobacteria,1XT5F@135623|Vibrionales 135623|Vibrionales C COG1271 Cytochrome bd-type quinol oxidase, subunit 1 cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_418654_1 1493511.A0A0E3FMD1_9CAUD 1.48e-55 199.0 4QEE7@10239|Viruses,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae 10662|Myoviridae S Pfam:DUF4815 - - - - - - - - - - - - - k59_1358944_1 926559.JoomaDRAFT_2622 6.15e-26 110.0 COG3540@1|root,COG3540@2|Bacteria,4NFXQ@976|Bacteroidetes,1HY2S@117743|Flavobacteriia 976|Bacteroidetes P PhoD-like phosphatase - - - - - - - - - - - - PhoD k59_1567801_1 562970.Btus_0153 6.19e-27 105.0 COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,4HAEN@91061|Bacilli,27800@186823|Alicyclobacillaceae 91061|Bacilli J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC GO:0008150,GO:0009893,GO:0010468,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0044087,GO:0044089,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090070,GO:2000232,GO:2000234 - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_1567801_2 1125863.JAFN01000001_gene3294 5.91e-52 165.0 COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,42SE4@68525|delta/epsilon subdivisions,2WP4K@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Involved in the binding of tRNA to the ribosomes rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_1567801_3 525903.Taci_1515 9.12e-90 274.0 COG0050@1|root,COG0050@2|Bacteria,3T9PS@508458|Synergistetes 508458|Synergistetes J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_523073_1 713587.THITH_09890 0.000182 48.9 COG0438@1|root,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,1RYRV@1236|Gammaproteobacteria,1WYTR@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase, group 1 - - 2.4.1.349 ko:K12994 - - - - ko00000,ko01000,ko01003,ko01005 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_418659_1 1123377.AUIV01000016_gene311 3.63e-29 113.0 COG3339@1|root,COG3339@2|Bacteria,1RAN7@1224|Proteobacteria,1S291@1236|Gammaproteobacteria,1X60S@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1232) - - - - - - - - - - - - DUF1232 k59_366501_1 582744.Msip34_0493 7.7e-71 221.0 COG0842@1|root,COG0842@2|Bacteria,1MUF4@1224|Proteobacteria,2W3RW@28216|Betaproteobacteria,2KNNH@206350|Nitrosomonadales 206350|Nitrosomonadales V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_1358947_1 491915.Aflv_2751 2.85e-44 165.0 COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,4H9SA@91061|Bacilli,21W8M@150247|Anoxybacillus 91061|Bacilli M Transglycosylase pbpG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.4.1.129,3.4.16.4 ko:K21464 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_314214_1 436308.Nmar_1309 8.93e-150 440.0 COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S7I@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18594 ko00720,ko01120,map00720,map01120 - R03157 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_784512_1 531844.FIC_02510 7.32e-61 200.0 COG0451@1|root,COG0451@2|Bacteria,4NEKA@976|Bacteroidetes,1HY26@117743|Flavobacteriia,4067D@61432|unclassified Flavobacteriaceae 976|Bacteroidetes M Male sterility protein - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_314215_2 243159.AFE_0160 3.33e-23 95.1 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,1RQ0Y@1236|Gammaproteobacteria,2NCX9@225057|Acidithiobacillales 225057|Acidithiobacillales Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_105214_1 1216976.AX27061_5861 8.84e-52 176.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2VICZ@28216|Betaproteobacteria,3T1R5@506|Alcaligenaceae 28216|Betaproteobacteria M Acyltransferase htrB1 - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_53238_1 1485544.JQKP01000001_gene932 9.5e-86 258.0 COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2VH27@28216|Betaproteobacteria,44VEN@713636|Nitrosomonadales 28216|Betaproteobacteria G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A,Sugar-bind k59_53238_2 1280952.HJA_13220 1.61e-111 338.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases MA20_01050 - 1.17.1.10 ko:K15022 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3 k59_262012_2 69279.BG36_11115 1.6e-36 137.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TS6B@28211|Alphaproteobacteria,43I0X@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O Trypsin-like peptidase domain - GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.107 ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_836619_1 870187.Thini_3978 2.53e-54 176.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,460NW@72273|Thiotrichales 72273|Thiotrichales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_836619_2 641147.HMPREF9021_01801 1.59e-18 87.4 COG0763@1|root,COG3266@1|root,COG0763@2|Bacteria,COG3266@2|Bacteria,1MVBI@1224|Proteobacteria,2VIBP@28216|Betaproteobacteria,2KPQB@206351|Neisseriales 206351|Neisseriales M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_750_1 1454004.AW11_01622 4.09e-09 62.8 COG2304@1|root,COG3419@1|root,COG2304@2|Bacteria,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria 28216|Betaproteobacteria NU pilus assembly protein tip-associated adhesin pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_993238_1 1479235.KK366039_gene459 7.95e-27 109.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1XHB9@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_993238_2 477228.YO5_10390 6.71e-52 170.0 COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,1S3XT@1236|Gammaproteobacteria,1YZQR@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - - - - - - - - - - SLT k59_53245_1 268746.Q58MK7_BPPRM 2.03e-38 141.0 4QAKZ@10239|Viruses,4QUSW@35237|dsDNA viruses no RNA stage,4QPYH@28883|Caudovirales,4QIYN@10662|Myoviridae 10662|Myoviridae S exonuclease activity - - - - - - - - - - - - - k59_53245_2 268746.Q58MK8_BPPRM 1.47e-21 87.8 4QBEN@10239|Viruses,4QW43@35237|dsDNA viruses no RNA stage,4QPWZ@28883|Caudovirales,4QI7M@10662|Myoviridae 10662|Myoviridae S Protein of unknown function (DUF3110) - - - - - - - - - - - - - k59_53245_3 445686.E3SL75_9CAUD 5.19e-59 194.0 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales,4QHXI@10662|Myoviridae 10662|Myoviridae S hydrolase activity - - - - - - - - - - - - - k59_1254563_1 519989.ECTPHS_04568 1.51e-44 150.0 COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,1S5X6@1236|Gammaproteobacteria,1WY50@135613|Chromatiales 135613|Chromatiales T low molecular weight - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc k59_576051_2 1437608.BBIA_0468 1.62e-07 52.0 COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria,4CZ5D@85004|Bifidobacteriales 201174|Actinobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_1359862_1 1380394.JADL01000001_gene2043 2.24e-121 367.0 COG0747@1|root,COG0747@2|Bacteria,1MU3P@1224|Proteobacteria,2TT4M@28211|Alphaproteobacteria,2JQ75@204441|Rhodospirillales 204441|Rhodospirillales E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_367409_1 497965.Cyan7822_0163 1.63e-20 90.1 COG0318@1|root,COG0318@2|Bacteria,1G2H0@1117|Cyanobacteria,3KIM3@43988|Cyanothece 1117|Cyanobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K00666,ko:K01897,ko:K18660 ko00061,ko00071,ko00280,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00280,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280,R03383 RC00004,RC00014,RC00137 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_785496_1 1123368.AUIS01000006_gene608 9.51e-85 258.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,2NCEK@225057|Acidithiobacillales 225057|Acidithiobacillales I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_993748_1 1248917.ANFX01000029_gene2670 1.25e-37 142.0 COG0654@1|root,COG0654@2|Bacteria,1MX9R@1224|Proteobacteria,2TR4U@28211|Alphaproteobacteria,2K3D6@204457|Sphingomonadales 204457|Sphingomonadales CH FAD binding domain - - 1.14.13.127 ko:K05712 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06786,R06787 RC00236 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_105795_1 1379281.AVAG01000072_gene714 4.77e-31 118.0 COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,42Q1D@68525|delta/epsilon subdivisions,2WJYJ@28221|Deltaproteobacteria,2M88U@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1150631_1 215803.DB30_5774 3.44e-80 266.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42M0A@68525|delta/epsilon subdivisions,2WIQY@28221|Deltaproteobacteria,2YTXB@29|Myxococcales 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_1150631_2 572477.Alvin_2516 5.32e-09 62.4 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1WWA8@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_941646_1 1235802.C823_05193 1.18e-09 62.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1 k59_471437_2 443255.SCLAV_5105 2.37e-78 244.0 COG5424@1|root,COG5424@2|Bacteria,2I9SS@201174|Actinobacteria 201174|Actinobacteria H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ pqqC - 1.3.3.11 ko:K06137 - - - - ko00000,ko01000 - - - TENA_THI-4 k59_1515927_1 551789.ATVJ01000001_gene1876 2.79e-41 155.0 COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria,1RM62@1224|Proteobacteria,2UPDY@28211|Alphaproteobacteria,440IE@69657|Hyphomonadaceae 28211|Alphaproteobacteria O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - - - - - - - - - - PPC k59_681064_1 937777.Deipe_0950 1.29e-07 60.1 COG2074@1|root,COG2074@2|Bacteria,1WI2U@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G 2-phosphoglycerate kinase - - - ko:K05715 - - R02664 RC00002,RC00017 ko00000,ko01000 - - - ATP-cone k59_1255570_1 323848.Nmul_A1100 2.27e-23 96.7 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2VJ4G@28216|Betaproteobacteria,371X0@32003|Nitrosomonadales 28216|Betaproteobacteria C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_1255570_2 265072.Mfla_2053 2.04e-38 132.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2VIQP@28216|Betaproteobacteria,2KM6I@206350|Nitrosomonadales 206350|Nitrosomonadales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_1568447_1 349124.Hhal_0661 1.25e-68 219.0 COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1WVUR@135613|Chromatiales 135613|Chromatiales E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_1568447_2 765911.Thivi_0414 4.53e-16 72.0 COG3242@1|root,COG3242@2|Bacteria,1PU4I@1224|Proteobacteria,1TK3B@1236|Gammaproteobacteria,1WZE8@135613|Chromatiales 135613|Chromatiales S Uncharacterized protein conserved in bacteria (DUF2065) - - - ko:K09937 - - - - ko00000 - - - DUF2065 k59_1568447_3 243365.CV_3530 0.000132 43.5 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2VI9W@28216|Betaproteobacteria,2KQQW@206351|Neisseriales 206351|Neisseriales O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_941648_1 754477.Q7C_1790 8.51e-74 248.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,45ZWK@72273|Thiotrichales 72273|Thiotrichales M TIGRFAM penicillin-binding protein, 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_941648_2 935567.JAES01000019_gene1009 1.42e-43 152.0 COG1418@1|root,COG1418@2|Bacteria,1RH6M@1224|Proteobacteria,1S81F@1236|Gammaproteobacteria,1X5UH@135614|Xanthomonadales 135614|Xanthomonadales S mRNA catabolic process - - - - - - - - - - - - - k59_941648_3 156578.ATW7_18185 1.92e-13 77.4 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_681073_1 243159.AFE_2618 1.11e-136 401.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,2NCKR@225057|Acidithiobacillales 225057|Acidithiobacillales C Proton-conducting membrane transporter - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_628899_1 1280950.HJO_05130 4.98e-27 107.0 COG1028@1|root,COG1028@2|Bacteria,1PFUB@1224|Proteobacteria,2U149@28211|Alphaproteobacteria,43ZCI@69657|Hyphomonadaceae 28211|Alphaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_628899_2 1229172.JQFA01000002_gene2579 4.12e-58 188.0 COG1853@1|root,COG1853@2|Bacteria,1G4QZ@1117|Cyanobacteria 1117|Cyanobacteria S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct k59_1255574_1 1415778.JQMM01000001_gene1138 1.88e-52 172.0 COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria,1J4YC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U COG0811 Biopolymer transport proteins - - - - - - - - - - - - MotA_ExbB k59_1255574_2 1279017.AQYJ01000022_gene2610 2.46e-36 140.0 2ASXF@1|root,31ID0@2|Bacteria,1RM30@1224|Proteobacteria,1S8I2@1236|Gammaproteobacteria,46BFQ@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_157838_2 1280944.HY17_03070 4.67e-47 155.0 COG2259@1|root,COG2259@2|Bacteria,1N06A@1224|Proteobacteria,2U6MK@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PFAM DoxX family protein - - - ko:K15977 - - - - ko00000 - - - DoxX k59_1464359_1 105559.Nwat_0602 1.65e-57 199.0 COG0741@1|root,COG0741@2|Bacteria,1MWRW@1224|Proteobacteria,1S084@1236|Gammaproteobacteria 1236|Gammaproteobacteria M lytic transglycosylase activity - - - - - - - - - - - - SLT,SPOR k59_681076_1 70448.A0A096PAH0 5.19e-72 236.0 COG1004@1|root,KOG2666@2759|Eukaryota 2759|Eukaryota M UDP-glucose 6-dehydrogenase activity - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_367436_1 1207055.C100_18075 6.46e-206 592.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2K20D@204457|Sphingomonadales 204457|Sphingomonadales EQ PFAM Hydantoinase oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_1255579_1 1379698.RBG1_1C00001G0769 3.58e-16 83.6 COG3637@1|root,COG3637@2|Bacteria,2NQC8@2323|unclassified Bacteria 2|Bacteria M Putative outer membrane beta-barrel porin, MtrB/PioB - - - ko:K22110 - - - - ko00000,ko02000 1.B.35.1,1.B.35.2 - - MtrB_PioB,OMP_b-brl,OMP_b-brl_2 k59_210611_1 765914.ThisiDRAFT_2355 3.16e-55 181.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_471460_1 713586.KB900536_gene1232 4.4e-08 57.4 2ECCV@1|root,336B4@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF2204 k59_1411736_1 268746.Q58M58_BPPRM 1.64e-25 113.0 4QFH9@10239|Viruses,4QPFW@28883|Caudovirales,4QJRX@10662|Myoviridae 10662|Myoviridae S Subtilase family - - - - - - - - - - - - - k59_1411736_2 445686.E3SLE8_9CAUD 9.36e-58 186.0 4QEPW@10239|Viruses,4QWA1@35237|dsDNA viruses no RNA stage,4QQ3S@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1203443_1 1121937.AUHJ01000001_gene493 2.19e-44 152.0 COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,466ZZ@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG2755 Lysophospholipase L1 and related esterases tesA GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365 Lipase_GDSL_2 k59_1098697_1 314285.KT71_10769 1.45e-99 294.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria,1J4HA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the SUA5 family yciO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Sua5_yciO_yrdC k59_1098697_2 768671.ThimaDRAFT_2027 1.46e-111 329.0 COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,1RNCG@1236|Gammaproteobacteria,1WXKB@135613|Chromatiales 135613|Chromatiales S pfam php - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_1203444_1 330214.NIDE3314 2.01e-61 206.0 COG0531@1|root,COG0531@2|Bacteria 2|Bacteria E amino acid - - - - - - - - - - - - AA_permease_2 k59_471461_1 1122604.JONR01000005_gene987 8.82e-76 245.0 COG1073@1|root,COG1073@2|Bacteria,1PQAX@1224|Proteobacteria,1RZIS@1236|Gammaproteobacteria,1X4J1@135614|Xanthomonadales 135614|Xanthomonadales S alpha beta - - - - - - - - - - - - Peptidase_S9 k59_681093_1 1348657.M622_13650 3.99e-73 246.0 COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,2WGS4@28216|Betaproteobacteria,2KU8N@206389|Rhodocyclales 206389|Rhodocyclales C Molydopterin dinucleotide binding domain - - 1.17.99.2 ko:K10700,ko:K17050 ko00642,ko01100,ko01120,ko01220,map00642,map01100,map01120,map01220 - R05745 RC00275 ko00000,ko00001,ko01000,ko02000 5.A.3.8,5.A.3.9 - - Molybdopterin,Molydop_binding k59_262891_1 1157943.KB892705_gene217 1.07e-60 211.0 COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,232MQ@1762|Mycobacteriaceae 201174|Actinobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC ctpF GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.8 ko:K01537,ko:K12953 - - - - ko00000,ko01000 3.A.3,3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_54325_1 1232410.KI421414_gene2883 7.72e-153 456.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,43SZI@69541|Desulfuromonadales 28221|Deltaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_419549_1 207954.MED92_02798 1.5e-09 64.3 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1XIMR@135619|Oceanospirillales 135619|Oceanospirillales O Highly conserved protein containing a thioredoxin domain - - - ko:K06888 - - - - ko00000 - - - DsbC,GlcNAc_2-epim,Thioredox_DsbH k59_628935_1 1537715.JQFJ01000002_gene2531 1.18e-78 241.0 COG3826@1|root,COG3826@2|Bacteria,1MWVV@1224|Proteobacteria,2TQMH@28211|Alphaproteobacteria,2K2AB@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - ko:K09990 - - - - ko00000 - - - Oxygenase-NA k59_1411751_1 397287.C807_01755 3.65e-49 176.0 COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,27IJI@186928|unclassified Lachnospiraceae 186801|Clostridia KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS16615 ACT_4,HD_4,RelA_SpoT,TGS k59_1568485_1 1229909.NSED_09685 2.63e-23 92.8 COG0071@1|root,arCOG01833@2157|Archaea,41SPJ@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_530323_1 436308.Nmar_1585 2.65e-84 261.0 COG0079@1|root,arCOG04273@2157|Archaea,41SGU@651137|Thaumarchaeota 651137|Thaumarchaeota E PFAM Aminotransferase class I and II - - 4.1.1.81 ko:K04720 ko00860,map00860 - R06530 RC00517 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_1211830_1 402626.Rpic_0253 0.000359 48.9 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,1K1RH@119060|Burkholderiaceae 28216|Betaproteobacteria O TPR repeat-containing protein - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 k59_739268_1 1448389.BAVQ01000029_gene656 4.04e-09 58.2 COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria 201174|Actinobacteria Q cytochrome P450 cyp51 GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0008398,GO:0016125,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0032451,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046906,GO:0048037,GO:0055114,GO:0070988,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901615 1.14.13.70 ko:K05917 ko00100,ko01100,ko01110,ko01130,map00100,map01100,map01110,map01130 M00101 R05640,R05731 RC01442 ko00000,ko00001,ko00002,ko00199,ko01000 - - - p450 k59_739268_2 342610.Patl_2175 3.56e-07 53.1 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1RQ2D@1236|Gammaproteobacteria,2PZWU@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases garR - 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1366322_2 756067.MicvaDRAFT_5019 8.32e-05 45.1 COG0745@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1G07W@1117|Cyanobacteria,1H781@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_689057_1 1288298.rosmuc_01903 1.45e-34 134.0 COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2TSQ2@28211|Alphaproteobacteria,46P7C@74030|Roseovarius 28211|Alphaproteobacteria P NnrS protein nnrS - - ko:K07234 - - - - ko00000 - - - NnrS k59_1211831_1 562970.Btus_2133 2.97e-57 188.0 COG1024@1|root,COG1024@2|Bacteria,1V4YE@1239|Firmicutes,4HTXK@91061|Bacilli,279Y1@186823|Alicyclobacillaceae 91061|Bacilli I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_1211831_2 745014.OMB55_00019880 0.000209 43.5 COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,1RPE2@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Enoyl-CoA hydratase - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_1053040_1 986075.CathTA2_0425 7.59e-79 250.0 COG0154@1|root,COG0154@2|Bacteria,1TPGJ@1239|Firmicutes,4HBE7@91061|Bacilli 91061|Bacilli J Belongs to the amidase family - - 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_478252_1 436308.Nmar_0308 3.68e-63 193.0 COG2146@1|root,arCOG02852@2157|Archaea,41SSE@651137|Thaumarchaeota 651137|Thaumarchaeota P Rieske 2Fe-2S - - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske k59_1628311_1 56780.SYN_00997 1e-32 118.0 COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,42RXS@68525|delta/epsilon subdivisions,2WNA0@28221|Deltaproteobacteria,2MQG0@213462|Syntrophobacterales 28221|Deltaproteobacteria K CarD-like/TRCF domain - - - ko:K07736 - - - - ko00000,ko03000 - - - CarD_CdnL_TRCF k59_1264859_1 927658.AJUM01000037_gene1865 6.87e-30 117.0 COG0767@1|root,COG0767@2|Bacteria,4NF7X@976|Bacteroidetes,2FSFN@200643|Bacteroidia 976|Bacteroidetes Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_4305_1 1117647.M5M_05260 3.53e-44 155.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1RPHB@1236|Gammaproteobacteria,1J7M0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_112663_1 1321775.HMPREF1980_01652 2.67e-07 56.6 COG2890@1|root,COG2890@2|Bacteria,2GJPP@201174|Actinobacteria,4D3F6@85005|Actinomycetales 201174|Actinobacteria J Methyltransferase rsmC - - - - - - - - - - - MTS k59_426809_1 1500894.JQNN01000001_gene2927 2.26e-22 95.5 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,2VHV6@28216|Betaproteobacteria,472UW@75682|Oxalobacteraceae 28216|Betaproteobacteria T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH - 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - - Metallophos k59_1157752_1 694431.DESACE_02110 8.35e-36 133.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2M6AK@213113|Desulfurellales 28221|Deltaproteobacteria I Carboxyl transferase domain pccB - 2.1.3.1,2.1.3.15,6.4.1.3 ko:K01966,ko:K17489 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R00353,R01859 RC00040,RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1575419_2 1156937.MFUM_90038 3.22e-09 63.5 COG2804@1|root,COG2804@2|Bacteria,46SDR@74201|Verrucomicrobia,37FWD@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia NU Type II/IV secretion system protein pulE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_739973_1 706587.Desti_1073 1.01e-30 124.0 COG1012@1|root,COG1012@2|Bacteria,1MV2I@1224|Proteobacteria,42R7M@68525|delta/epsilon subdivisions,2WMUH@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Succinylglutamic semialdehyde dehydrogenase astD - 1.2.1.71 ko:K06447 ko00330,ko01100,map00330,map01100 - R05049 RC00080 ko00000,ko00001,ko01000 - - - Aldedh k59_739973_2 246196.MSMEI_1379 1.18e-06 53.9 COG1834@1|root,COG1834@2|Bacteria,2GNTN@201174|Actinobacteria,235HW@1762|Mycobacteriaceae 201174|Actinobacteria E PFAM amidinotransferase - GO:0003674,GO:0003824,GO:0016403,GO:0016787,GO:0016810,GO:0016813 - - - - - - - - - - Amidinotransf k59_897110_1 395494.Galf_1315 3.9e-33 131.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG0642@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2WGMB@28216|Betaproteobacteria,44WAV@713636|Nitrosomonadales 28216|Betaproteobacteria T Cache domain - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Reg_prop,Response_reg,Y_Y_Y,dCache_1 k59_844712_1 194867.ALBQ01000004_gene3518 3.43e-37 138.0 COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,2TR0E@28211|Alphaproteobacteria,2K0JX@204457|Sphingomonadales 204457|Sphingomonadales E phospho-2-dehydro-3-deoxyheptonate aldolase aroF - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_2 k59_1212765_1 1121448.DGI_0773 7e-10 60.5 COG0160@1|root,COG0160@2|Bacteria,1QTZ3@1224|Proteobacteria,43D42@68525|delta/epsilon subdivisions,2X8AU@28221|Deltaproteobacteria,2MHF9@213115|Desulfovibrionales 28221|Deltaproteobacteria E Aminotransferase class-III - - 2.6.1.19 ko:K00823 ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1106062_2 338966.Ppro_0558 9.4e-31 118.0 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,42U8G@68525|delta/epsilon subdivisions,2WQPS@28221|Deltaproteobacteria,43USX@69541|Desulfuromonadales 28221|Deltaproteobacteria Q MlaC protein - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_63596_2 113355.CM001775_gene1895 2.71e-08 57.4 COG0642@1|root,COG0745@1|root,COG2202@1|root,COG2203@1|root,COG2905@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2905@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CBS,GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg k59_638151_1 1267535.KB906767_gene1411 8.07e-14 72.4 COG1506@1|root,COG1506@2|Bacteria,3Y357@57723|Acidobacteria,2JIKY@204432|Acidobacteriia 204432|Acidobacteriia E Tannase and feruloyl esterase - - - - - - - - - - - - Tannase k59_479181_1 1304883.KI912532_gene1743 8.86e-58 193.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,2KVTZ@206389|Rhodocyclales 206389|Rhodocyclales KT HD domain - - - - - - - - - - - - HD,HD_5 k59_1419279_1 870187.Thini_0421 2.31e-96 294.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,4606R@72273|Thiotrichales 72273|Thiotrichales L ATPase (AAA - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_1367066_1 444860.E3SIZ0_9CAUD 1.79e-90 288.0 4QF7I@10239|Viruses,4QYCA@35237|dsDNA viruses no RNA stage,4QT9A@28883|Caudovirales,4QKJH@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1264900_1 1397528.Q671_14125 5.5e-27 108.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1XI0U@135619|Oceanospirillales 135619|Oceanospirillales J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_1264900_2 545276.KB898730_gene1402 3.05e-32 115.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1WYAE@135613|Chromatiales 135613|Chromatiales F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_217863_1 1524467.IV04_02595 1.3e-14 72.8 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,401D1@613|Serratia 1236|Gammaproteobacteria H ThiF family moeB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0061605,GO:0070566,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - iECIAI1_1343.ECIAI1_0865,iECW_1372.ECW_m0884,iEKO11_1354.EKO11_3059,iETEC_1333.ETEC_0893,iEcE24377_1341.EcE24377A_0897,iEcSMS35_1347.EcSMS35_0851,iWFL_1372.ECW_m0884 ThiF k59_217863_2 1123023.JIAI01000003_gene2681 1.48e-25 100.0 COG1310@1|root,COG1310@2|Bacteria,2IFB5@201174|Actinobacteria,4E2VD@85010|Pseudonocardiales 201174|Actinobacteria S metal-dependent protease of the PAD1 JAB1 superfamily mec GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006508,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016787,GO:0019344,GO:0019538,GO:0019752,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.13.1.6 ko:K21140 ko04122,map04122 - R11524 RC00064,RC00090 ko00000,ko00001,ko01000 - - - Prok-JAB k59_4319_1 222534.KB893728_gene5648 6.7e-49 173.0 COG0318@1|root,COG0318@2|Bacteria,2IEKP@201174|Actinobacteria,4EX2P@85013|Frankiales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1000695_1 314345.SPV1_00772 4.84e-77 240.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria 1224|Proteobacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1360 Ldh_1_C,Ldh_1_N k59_1000695_2 1242864.D187_007617 1.61e-159 460.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2WJTS@28221|Deltaproteobacteria,2YU09@29|Myxococcales 28221|Deltaproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2261 ATP-grasp_2,Ligase_CoA k59_1367072_1 257310.BB1025 9.64e-68 221.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2VJSF@28216|Betaproteobacteria,3T6Z5@506|Alcaligenaceae 28216|Betaproteobacteria P C-terminal region of aryl-sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_217865_1 1038859.AXAU01000003_gene6186 8.04e-105 323.0 COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2TS3W@28211|Alphaproteobacteria,3JTIG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria V Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides - - - ko:K02003,ko:K05685 ko02010,map02010 M00258,M00709 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.122.1,3.A.1.122.12 - - ABC_tran,FtsX,MacB_PCD k59_217865_2 546262.NEICINOT_03148 2.36e-10 62.4 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2VIZ7@28216|Betaproteobacteria,2KQ45@206351|Neisseriales 206351|Neisseriales C Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.2 ko:K00260 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_897132_1 436308.Nmar_0059 5.11e-24 97.1 COG2875@1|root,arCOG00645@2157|Archaea,41SE7@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.133,2.1.1.271 ko:K05936 ko00860,ko01100,map00860,map01100 - R05181,R05810 RC00003,RC01294,RC02049 ko00000,ko00001,ko01000 - - - TP_methylase k59_897132_2 1131266.ARWQ01000001_gene1296 3.64e-34 127.0 COG1794@1|root,arCOG02005@2157|Archaea,41SM4@651137|Thaumarchaeota 651137|Thaumarchaeota M Asp/Glu/Hydantoin racemase - - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_948549_1 981384.AEYW01000001_gene1490 7.55e-107 326.0 COG1234@1|root,COG1234@2|Bacteria,1RIJP@1224|Proteobacteria 1224|Proteobacteria S Metallo-beta-lactamase superfamily - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B,Lactamase_B_4 k59_112705_1 472759.Nhal_1348 3.12e-94 290.0 COG1858@1|root,COG1858@2|Bacteria,1RC4D@1224|Proteobacteria,1SJKT@1236|Gammaproteobacteria 1236|Gammaproteobacteria C cytochrome C peroxidase - - - - - - - - - - - - - k59_1575456_1 1229909.NSED_06385 4.85e-67 213.0 COG0372@1|root,arCOG04237@2157|Archaea,41SAN@651137|Thaumarchaeota 651137|Thaumarchaeota C TIGRFAM 2-methylcitrate synthase citrate synthase II - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_1575456_2 436308.Nmar_1100 4.37e-43 140.0 arCOG08706@1|root,arCOG08706@2157|Archaea,41SUP@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_844743_1 748658.KB907313_gene2227 1.04e-95 291.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WWH3@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_844743_2 1469245.JFBG01000086_gene1622 2.55e-65 219.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, chain G - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1367084_1 391625.PPSIR1_10520 8.35e-66 207.0 COG0300@1|root,COG0300@2|Bacteria,1NGXF@1224|Proteobacteria,42Q5Q@68525|delta/epsilon subdivisions,2WNMS@28221|Deltaproteobacteria,2YV1C@29|Myxococcales 28221|Deltaproteobacteria S COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - Radical_SAM,adh_short k59_270228_1 511062.GU3_15540 1.51e-129 387.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1Y3TE@135624|Aeromonadales 135624|Aeromonadales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_531094_1 926559.JoomaDRAFT_3617 2.27e-121 369.0 COG1529@1|root,COG1529@2|Bacteria,4NFFU@976|Bacteroidetes,1HXJS@117743|Flavobacteriia 976|Bacteroidetes C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_426860_2 1128912.GMES_3643 3.35e-25 101.0 COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,1SD1K@1236|Gammaproteobacteria,468DI@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TerB k59_426860_3 1122947.FR7_2663 9.62e-06 50.1 COG0697@1|root,COG0697@2|Bacteria,1UH2I@1239|Firmicutes,4H63J@909932|Negativicutes 909932|Negativicutes EG EamA-like transporter family - - - - - - - - - - - - EamA k59_689827_1 1163617.SCD_n00349 1.44e-138 414.0 COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,2VM8J@28216|Betaproteobacteria 28216|Betaproteobacteria C Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide nosZ - 1.7.2.4 ko:K00376 ko00910,ko01120,map00910,map01120 M00529 R02804 RC02861 ko00000,ko00001,ko00002,ko01000 - - - Cupredoxin_1 k59_583331_1 130081.XP_005708572.1 1.55e-87 275.0 COG1171@1|root,KOG1251@2759|Eukaryota 2759|Eukaryota E serine racemase SRR GO:0000166,GO:0000287,GO:0002237,GO:0003674,GO:0003824,GO:0003941,GO:0005488,GO:0005509,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006090,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007568,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008721,GO:0009058,GO:0009069,GO:0009070,GO:0009410,GO:0009605,GO:0009607,GO:0009617,GO:0009987,GO:0010033,GO:0010243,GO:0014070,GO:0014072,GO:0016020,GO:0016043,GO:0016053,GO:0016594,GO:0016597,GO:0016829,GO:0016840,GO:0016841,GO:0016853,GO:0016854,GO:0016855,GO:0017076,GO:0017144,GO:0018114,GO:0019752,GO:0019842,GO:0019904,GO:0022607,GO:0030165,GO:0030170,GO:0030378,GO:0030554,GO:0031406,GO:0032496,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033993,GO:0035639,GO:0036094,GO:0036361,GO:0036477,GO:0042165,GO:0042221,GO:0042493,GO:0042802,GO:0042803,GO:0042866,GO:0043025,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043207,GO:0043278,GO:0043279,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044297,GO:0044424,GO:0044444,GO:0044464,GO:0045177,GO:0046394,GO:0046416,GO:0046437,GO:0046872,GO:0046983,GO:0047661,GO:0048037,GO:0048513,GO:0048731,GO:0048856,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051704,GO:0051707,GO:0060322,GO:0060359,GO:0065003,GO:0070178,GO:0070179,GO:0070279,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072347,GO:0097159,GO:0097367,GO:0097458,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901698,GO:1901700 2.7.10.2,4.3.1.19,5.1.1.18 ko:K01754,ko:K12235,ko:K17538,ko:K19413,ko:K21851 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00589,R00996 RC00302,RC00418,RC02600 ko00000,ko00001,ko00002,ko01000,ko01001,ko03036,ko04131 - - - PALP k59_1000720_1 459495.SPLC1_S033050 3.61e-05 53.1 COG3187@1|root,COG3187@2|Bacteria,1G96Y@1117|Cyanobacteria,1HCV1@1150|Oscillatoriales 1117|Cyanobacteria O META domain - - - ko:K03668 - - - - ko00000 - - - DUF4377,META k59_1157801_1 177439.DP2613 3.1e-46 170.0 COG0532@1|root,COG3064@1|root,COG0532@2|Bacteria,COG3064@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MIGT@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_1575470_2 1122599.AUGR01000009_gene2416 7.31e-19 87.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1S5IM@1236|Gammaproteobacteria,1XMWN@135619|Oceanospirillales 135619|Oceanospirillales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_163576_1 713587.THITH_08610 3.57e-127 383.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1WW4U@135613|Chromatiales 135613|Chromatiales L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1106117_1 864051.BurJ1DRAFT_3306 4.98e-18 85.1 COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,2VKWX@28216|Betaproteobacteria,1KKAX@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_1106117_2 1163617.SCD_n00803 1.1e-15 75.5 COG0095@1|root,COG0095@2|Bacteria,1N1T8@1224|Proteobacteria,2VQNY@28216|Betaproteobacteria 28216|Betaproteobacteria H lipoate-protein ligase A lplA - 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_1419344_2 536227.CcarbDRAFT_2872 3.05e-14 72.8 COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,24N7H@186801|Clostridia,36JPF@31979|Clostridiaceae 186801|Clostridia H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family fthC - 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig k59_1053801_2 330214.NIDE3720 9.49e-34 117.0 COG1722@1|root,COG1722@2|Bacteria 2|Bacteria L exodeoxyribonuclease VII activity xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S k59_638219_1 706587.Desti_3709 9.79e-12 66.6 COG0711@1|root,COG0711@2|Bacteria,1N97K@1224|Proteobacteria,42VYP@68525|delta/epsilon subdivisions,2WR6T@28221|Deltaproteobacteria,2MS4A@213462|Syntrophobacterales 28221|Deltaproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_638219_2 502025.Hoch_6065 1.29e-38 137.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,42U68@68525|delta/epsilon subdivisions,2WQJS@28221|Deltaproteobacteria,2Z301@29|Myxococcales 28221|Deltaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_897172_1 1123393.KB891332_gene2798 2.07e-28 107.0 COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,2VRMS@28216|Betaproteobacteria,1KS17@119069|Hydrogenophilales 119069|Hydrogenophilales C ATP synthase B/B' CF(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_897172_2 580332.Slit_2986 1.96e-38 129.0 COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,2VTY0@28216|Betaproteobacteria,44W3S@713636|Nitrosomonadales 28216|Betaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_1106131_1 436308.Nmar_1597 6.48e-98 296.0 COG0043@1|root,arCOG01671@2157|Archaea,41SEQ@651137|Thaumarchaeota 651137|Thaumarchaeota H UbiD family decarboxylase - - - - - - - - - - - - UbiD k59_1628410_1 1283300.ATXB01000001_gene2275 2.33e-78 263.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1XEG1@135618|Methylococcales 135618|Methylococcales F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_795039_2 1493508.A0A0E3FSZ1_9CAUD 7.1e-98 327.0 4QEE7@10239|Viruses,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae 10662|Myoviridae S Pfam:DUF4815 - - - - - - - - - - - - - k59_323025_1 1502850.FG91_01562 3.01e-11 65.9 COG1835@1|root,COG1835@2|Bacteria,1PVUR@1224|Proteobacteria,2TTRB@28211|Alphaproteobacteria,2K98C@204457|Sphingomonadales 204457|Sphingomonadales I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_844783_2 523794.Lebu_0499 1.33e-43 158.0 COG2759@1|root,COG2759@2|Bacteria,37930@32066|Fusobacteria 32066|Fusobacteria H Formyltetrahydrofolate synthetase fhs GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_374760_1 342113.DM82_5055 1.29e-31 115.0 COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2VRN8@28216|Betaproteobacteria,1K4S6@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM CBS domain containing protein - - - - - - - - - - - - CBS k59_647239_1 202698.XP_007384836.1 4.85e-18 82.0 COG1011@1|root,KOG3085@2759|Eukaryota,38VQ7@33154|Opisthokonta,3NVUE@4751|Fungi,3V0RQ@5204|Basidiomycota,228GF@155619|Agaricomycetes,3H1C6@355688|Agaricomycetes incertae sedis 4751|Fungi S Haloacid dehalogenase-like hydrolase - - 3.3.2.9 ko:K01253 ko00980,ko04976,ko05204,map00980,map04976,map05204 - R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443 RC01447,RC01728,RC01764,RC02528 ko00000,ko00001,ko01000,ko01002 - - - HAD_2 k59_647239_2 118166.JH976537_gene2333 7.36e-37 135.0 COG2962@1|root,COG2962@2|Bacteria,1G24I@1117|Cyanobacteria,1HAFC@1150|Oscillatoriales 1117|Cyanobacteria S EamA-like transporter family - - - ko:K05786 - - - - ko00000,ko02000 2.A.7.7 - - EamA k59_1060927_1 631454.N177_3418 7.64e-102 306.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,1JN0K@119043|Rhodobiaceae 28211|Alphaproteobacteria E TOBE domain potA - - ko:K02052 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - ABC_tran,TOBE_2 k59_647240_1 935565.JAEM01000016_gene1474 2.05e-60 197.0 COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria,2PYFF@265|Paracoccus 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - ko:K18244 - - - - ko00000,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_647240_2 1380355.JNIJ01000001_gene3900 1.21e-77 244.0 COG1171@1|root,COG1171@2|Bacteria,1QTY3@1224|Proteobacteria,2VEUV@28211|Alphaproteobacteria,3JT83@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Pyridoxal-phosphate dependent enzyme - - 4.3.1.15 ko:K01751 - - - - ko00000,ko01000 - - - PALP k59_1428334_1 1185876.BN8_00223 3.55e-37 140.0 COG4636@1|root,COG4636@2|Bacteria,4NFKR@976|Bacteroidetes,47K44@768503|Cytophagia 976|Bacteroidetes S Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - - - - - - - - - - VCBS k59_1582400_1 1105367.CG50_04615 4.79e-48 166.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2TSK2@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TRAP transporter solute receptor TAXI family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_72579_1 882378.RBRH_03194 3.17e-53 188.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,1K2P6@119060|Burkholderiaceae 28216|Betaproteobacteria C Malic enzyme maeB - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malate_DH,Malic_M,PTA_PTB,malic k59_590262_1 571166.KI421509_gene1512 5.17e-70 222.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2TR6G@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1219849_1 330214.NIDE3772 2.96e-72 221.0 COG1278@1|root,COG1544@1|root,COG1278@2|Bacteria,COG1544@2|Bacteria 2|Bacteria J regulation of translation raiA - - ko:K03704,ko:K05809 - - - - ko00000,ko03000,ko03009 - - - CSD,Ribosomal_S30AE k59_329866_1 289376.THEYE_A0785 1.17e-104 320.0 COG0119@1|root,COG0119@2|Bacteria,3J0DC@40117|Nitrospirae 40117|Nitrospirae E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_329869_1 313606.M23134_01129 9.01e-29 115.0 COG3239@1|root,COG3239@2|Bacteria,4P03Y@976|Bacteroidetes 976|Bacteroidetes I Fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_329869_2 314225.ELI_08555 0.000187 44.3 COG1028@1|root,COG1028@2|Bacteria,1QU4S@1224|Proteobacteria,2VFC9@28211|Alphaproteobacteria,2KAC5@204457|Sphingomonadales 204457|Sphingomonadales IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_1007911_1 561177.ANHYDRO_00686 1.74e-36 140.0 COG0462@1|root,COG1207@1|root,COG0462@2|Bacteria,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia,22G7Q@1570339|Peptoniphilaceae 186801|Clostridia M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase k59_1582424_1 948106.AWZT01000001_gene5465 1.63e-164 482.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria,1K1A3@119060|Burkholderiaceae 28216|Betaproteobacteria G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_1482029_1 471875.RUMLAC_00568 1.39e-32 125.0 COG2355@1|root,COG2355@2|Bacteria,1UA7M@1239|Firmicutes,24AE6@186801|Clostridia,3WJ0Z@541000|Ruminococcaceae 186801|Clostridia E Renal dipeptidase family protein - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_1428365_2 1353529.M899_2604 8.22e-18 92.4 2FFQC@1|root,347MN@2|Bacteria,1P3GT@1224|Proteobacteria,431QA@68525|delta/epsilon subdivisions,2MUA6@213481|Bdellovibrionales,2WWK6@28221|Deltaproteobacteria 213481|Bdellovibrionales - - - - - - - - - - - - - - - k59_851621_1 1397528.Q671_08375 1.09e-112 346.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1XIN2@135619|Oceanospirillales 135619|Oceanospirillales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_120800_1 1219065.VPR01S_02_01940 4.44e-05 45.8 COG0346@1|root,COG0346@2|Bacteria,1RI06@1224|Proteobacteria,1S6JV@1236|Gammaproteobacteria,1XXGS@135623|Vibrionales 135623|Vibrionales E COG0346 Lactoylglutathione lyase and related lyases - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_120800_2 1205680.CAKO01000040_gene1084 6.19e-14 72.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria,2JRI5@204441|Rhodospirillales 204441|Rhodospirillales P Flavin-binding monooxygenase-like - - - - - - - - - - - - FMO-like k59_120800_3 1223542.GM1_004_01400 8.91e-05 44.3 COG2072@1|root,COG2072@2|Bacteria,2GJEA@201174|Actinobacteria,4GB0E@85026|Gordoniaceae 201174|Actinobacteria P Flavin-binding monooxygenase-like - - - - - - - - - - - - FMO-like,Pyr_redox_3 k59_1060968_1 1435356.Y013_24505 1.99e-09 56.6 COG4308@1|root,COG4308@2|Bacteria,2IP4X@201174|Actinobacteria,4G2E2@85025|Nocardiaceae 201174|Actinobacteria Q Limonene-1,2-epoxide hydrolase catalytic domain - - 3.3.2.8 ko:K10533 ko00903,map00903 - R05784,R09387 RC01473,RC02519 ko00000,ko00001,ko01000 - - - LEH k59_1060968_2 931627.MycrhDRAFT_0477 4.69e-16 80.1 COG2141@1|root,COG2141@2|Bacteria,2GNE9@201174|Actinobacteria,232XS@1762|Mycobacteriaceae 201174|Actinobacteria C F420-dependent oxidoreductase - - - - - - - - - - - - Bac_luciferase k59_1163471_1 330214.NIDE1217 2.41e-75 241.0 COG1232@1|root,COG1232@2|Bacteria,3J0PQ@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX - - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_1428374_2 765910.MARPU_16675 5.87e-42 154.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1WWAT@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_1113003_1 861299.J421_2711 7.92e-17 78.6 COG0457@1|root,COG0457@2|Bacteria,1ZTX0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_11 k59_1163478_1 999541.bgla_1g27620 6.47e-66 209.0 COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,2VKSE@28216|Betaproteobacteria,1K1VX@119060|Burkholderiaceae 28216|Betaproteobacteria S beta-lactamase - - - - - - - - - - - - Lactamase_B_2 k59_1060980_1 448385.sce4283 3.96e-23 99.8 COG0451@1|root,COG0451@2|Bacteria,1N8PG@1224|Proteobacteria,42UM2@68525|delta/epsilon subdivisions,2WR61@28221|Deltaproteobacteria,2YVAU@29|Myxococcales 28221|Deltaproteobacteria GM NAD dependent epimerase/dehydratase family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_1060980_2 1048339.KB913029_gene3098 4.23e-09 59.3 COG0451@1|root,COG3848@1|root,COG0451@2|Bacteria,COG3848@2|Bacteria,2H2J1@201174|Actinobacteria 201174|Actinobacteria T PEP-utilising enzyme, mobile domain - - - - - - - - - - - - Epimerase,PEP-utilizers k59_590290_1 519989.ECTPHS_13233 1.73e-58 187.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1WXDE@135613|Chromatiales 135613|Chromatiales J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_224808_1 1034943.BN1094_02862 6.43e-69 238.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1JDMD@118969|Legionellales 118969|Legionellales L DEAD/H associated - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_1007945_1 1279017.AQYJ01000026_gene65 6.48e-60 209.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,46DC5@72275|Alteromonadaceae 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_537841_2 751994.AGIG01000035_gene362 9.27e-27 103.0 COG2010@1|root,COG2010@2|Bacteria,1N91W@1224|Proteobacteria,1SD5N@1236|Gammaproteobacteria,1JAGD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c soxX - - ko:K17223 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - Cytochrom_C,Cytochrome_CBB3 k59_1636161_2 436308.Nmar_1051 2.43e-54 179.0 arCOG10557@1|root,arCOG10557@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_590294_1 751945.Theos_0793 3.41e-21 99.0 COG2262@1|root,COG2262@2|Bacteria,1WIJS@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_590294_2 1123239.KB898627_gene3624 7.03e-05 45.8 COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,4HANB@91061|Bacilli 91061|Bacilli O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_120826_2 927677.ALVU02000001_gene2931 1.44e-67 219.0 COG0044@1|root,COG0044@2|Bacteria,1G2H3@1117|Cyanobacteria 1117|Cyanobacteria F TIGRFAM dihydroorotase, multifunctional complex type pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_1428392_1 329726.AM1_6143 6.26e-19 88.6 COG1028@1|root,COG1028@2|Bacteria,1G4CA@1117|Cyanobacteria 1117|Cyanobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1428392_2 468059.AUHA01000003_gene1856 8.78e-20 87.4 COG0702@1|root,COG0702@2|Bacteria,4NICI@976|Bacteroidetes,1IT5M@117747|Sphingobacteriia 976|Bacteroidetes GM NmrA-like family - - - - - - - - - - - - NmrA k59_1582449_1 335283.Neut_1603 3.3e-43 150.0 COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,2VSFV@28216|Betaproteobacteria,372F6@32003|Nitrosomonadales 28216|Betaproteobacteria O Thiol disulfide interchange protein dsbA - - ko:K03673 ko01503,map01503 M00728 - - ko00000,ko00001,ko00002,ko03110 - - - DSBA,Thioredoxin_4 k59_1582449_2 1123401.JHYQ01000036_gene1683 3.49e-65 206.0 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,460ST@72273|Thiotrichales 72273|Thiotrichales C PFAM cytochrome c - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_1582449_3 1121937.AUHJ01000008_gene2027 4.47e-41 142.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,466MM@72275|Alteromonadaceae 1236|Gammaproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_170473_1 585.DR95_225 5.9e-111 347.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,3Z1PR@583|Proteus 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0032774,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1113018_1 330214.NIDE1254 6.57e-59 202.0 COG1640@1|root,COG1640@2|Bacteria,3J106@40117|Nitrospirae 40117|Nitrospirae G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_1319967_1 1444711.CCJF01000005_gene555 1.12e-31 123.0 COG1721@1|root,COG1721@2|Bacteria,2JFXY@204428|Chlamydiae 204428|Chlamydiae S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_1319967_2 344747.PM8797T_13967 6.29e-18 83.6 COG0714@1|root,COG0714@2|Bacteria,2IX23@203682|Planctomycetes 203682|Planctomycetes S PFAM ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1163496_1 268746.Q58M60_BPPRM 1.02e-12 75.5 4QCIK@10239|Viruses,4QZTG@35237|dsDNA viruses no RNA stage,4QTSK@28883|Caudovirales,4QJ3M@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_488504_1 935557.ATYB01000009_gene734 2.56e-59 209.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,4BBZJ@82115|Rhizobiaceae 28211|Alphaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_9 k59_1219919_2 877418.ATWV01000011_gene80 2.11e-11 65.1 COG0606@1|root,COG0606@2|Bacteria,2J59R@203691|Spirochaetes 203691|Spirochaetes O magnesium chelatase - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_72664_1 983328.AFGH01000004_gene1264 1.27e-84 275.0 COG2010@1|root,COG4263@1|root,COG2010@2|Bacteria,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,42P9D@68525|delta/epsilon subdivisions,2YMS2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome C oxidase subunit II, periplasmic domain nosZ - 1.7.2.4 ko:K00376 ko00910,ko01120,map00910,map01120 M00529 R02804 RC02861 ko00000,ko00001,ko00002,ko01000 - - - COX2,Cupredoxin_1,Cytochrom_C k59_1428415_1 1192034.CAP_9006 2.62e-75 242.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YTW0@29|Myxococcales 28221|Deltaproteobacteria T response regulator - - - ko:K02481,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1525488_2 268746.Q58M87_BPPRM 1.48e-32 118.0 4QB7U@10239|Viruses,4QSDB@28883|Caudovirales,4QIN1@10662|Myoviridae 10662|Myoviridae S transferase activity, transferring hexosyl groups - - - - - - - - - - - - - k59_537876_1 1260251.SPISAL_06875 3.29e-11 60.5 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,1WYVR@135613|Chromatiales 135613|Chromatiales K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ k59_537876_2 1121921.KB898709_gene196 1.13e-09 57.8 COG0810@1|root,COG0810@2|Bacteria,1PEDH@1224|Proteobacteria,1RRNT@1236|Gammaproteobacteria,2PNJ6@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_384023_1 402626.Rpic_1340 1.89e-39 149.0 COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2VHBN@28216|Betaproteobacteria,1K0YU@119060|Burkholderiaceae 28216|Betaproteobacteria G PFAM glycoside hydrolase 15-related - - - - - - - - - - - - Glyco_hydro_15 k59_384027_1 414684.RC1_0799 4.59e-66 210.0 COG1196@1|root,COG1196@2|Bacteria,1NGHR@1224|Proteobacteria,2UA8C@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Protein of unknown function (DUF3450) - - - - - - - - - - - - DUF3450 k59_591053_1 439235.Dalk_2931 7.95e-14 71.6 COG0659@1|root,COG2204@1|root,COG0659@2|Bacteria,COG2204@2|Bacteria,1MWDF@1224|Proteobacteria,43AD6@68525|delta/epsilon subdivisions,2WJCC@28221|Deltaproteobacteria,2MJ5W@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM sulfate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_434779_1 345341.KUTG_02610 3.73e-19 90.9 COG2141@1|root,COG2141@2|Bacteria,2GNQ1@201174|Actinobacteria,4E1GS@85010|Pseudonocardiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1220819_1 99598.Cal7507_4702 1.04e-128 396.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1G1HW@1117|Cyanobacteria,1HJRQ@1161|Nostocales 1117|Cyanobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P k59_278237_2 867903.ThesuDRAFT_01452 1.76e-25 107.0 COG0108@1|root,COG0307@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0307@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,248B0@186801|Clostridia,3WCXY@538999|Clostridiales incertae sedis 186801|Clostridia H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS10830 DHBP_synthase,GTP_cyclohydro2 k59_904916_1 880073.Calab_0624 1.38e-60 200.0 COG0282@1|root,COG0282@2|Bacteria,2NNXT@2323|unclassified Bacteria 2|Bacteria C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv0409 Acetate_kinase k59_489499_1 439235.Dalk_1865 1.46e-33 122.0 COG1305@1|root,COG1305@2|Bacteria,1R9XR@1224|Proteobacteria,42QTZ@68525|delta/epsilon subdivisions,2WMV1@28221|Deltaproteobacteria,2MJRM@213118|Desulfobacterales 28221|Deltaproteobacteria E Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core k59_489499_2 10160.XP_004632948.1 9.89e-12 65.5 COG0028@1|root,KOG1185@2759|Eukaryota,38EFU@33154|Opisthokonta,3BEH9@33208|Metazoa,3D030@33213|Bilateria,48622@7711|Chordata,496QH@7742|Vertebrata,3JD6E@40674|Mammalia,35GGD@314146|Euarchontoglires,4Q1R8@9989|Rodentia 33208|Metazoa EH acetolactate synthase)-like ILVBL GO:0001501,GO:0005575,GO:0007275,GO:0008150,GO:0009653,GO:0009790,GO:0009792,GO:0009887,GO:0016020,GO:0032501,GO:0032502,GO:0043009,GO:0048513,GO:0048562,GO:0048568,GO:0048598,GO:0048701,GO:0048704,GO:0048705,GO:0048706,GO:0048731,GO:0048856,GO:1904888 - ko:K11259 - - - - ko00000,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1061841_1 237368.SCABRO_03660 1.04e-106 330.0 COG3387@1|root,COG3387@2|Bacteria 2|Bacteria G glucan 1,4-alpha-glucosidase activity - - 3.2.1.40 ko:K05989,ko:K20541 - - - - ko00000,ko01000,ko02000 4.D.3.1.6 - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,fn3 k59_171181_2 1220535.IMCC14465_17390 4.19e-52 186.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_384049_1 47716.JOFH01000041_gene1196 1.17e-59 202.0 COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria 201174|Actinobacteria H Molybdenum cofactor synthesis domain protein moeA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.10.1.1,2.7.7.9 ko:K00963,ko:K03750 ko00040,ko00052,ko00500,ko00520,ko00790,ko01100,ko01130,map00040,map00052,map00500,map00520,map00790,map01100,map01130 M00129,M00361,M00362,M00549 R00289,R09735 RC00002,RC03462 ko00000,ko00001,ko00002,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_805363_1 450851.PHZ_c2095 1.36e-82 257.0 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,2TSXW@28211|Alphaproteobacteria,2KFBS@204458|Caulobacterales 204458|Caulobacterales G Major Facilitator - - - - - - - - - - - - MFS_1 k59_591068_1 1499967.BAYZ01000123_gene2530 1.21e-87 279.0 COG2192@1|root,COG2192@2|Bacteria,2NNRR@2323|unclassified Bacteria 2|Bacteria O Carbamoyltransferase C-terminus - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_1483090_1 187272.Mlg_0587 3.3e-34 131.0 COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales 135613|Chromatiales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_805372_2 317025.Tcr_1771 1.88e-22 93.6 COG1595@1|root,COG1595@2|Bacteria,1R9ZN@1224|Proteobacteria,1S7BJ@1236|Gammaproteobacteria,462N7@72273|Thiotrichales 72273|Thiotrichales K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1325576_1 55601.VANGNB10_cII0960 5.37e-73 230.0 COG0363@1|root,COG0363@2|Bacteria,1QXIZ@1224|Proteobacteria,1SB0N@1236|Gammaproteobacteria,1XT94@135623|Vibrionales 135623|Vibrionales G COG0363 6-phosphogluconolactonase Glucosamine-6-phosphate isomerase deaminase pgl - 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_597836_1 1255043.TVNIR_2017 1.68e-112 352.0 COG0247@1|root,COG0277@1|root,COG1146@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG1146@2|Bacteria,1MU6Y@1224|Proteobacteria,1RM7Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S ferredoxin lldE - - ko:K18930 - - - - ko00000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_7,Fer4_8 k59_391116_1 536227.CcarbDRAFT_4636 4.34e-06 53.9 COG0627@1|root,COG0627@2|Bacteria,1VT84@1239|Firmicutes,24FKY@186801|Clostridia,36G2F@31979|Clostridiaceae 186801|Clostridia S PFAM Tannase and feruloyl esterase - - 3.1.1.102 ko:K21105 - - R11541 RC00020,RC00041 ko00000,ko01000 - - - Tannase k59_442587_1 382464.ABSI01000010_gene3669 1.24e-49 165.0 COG1622@1|root,COG1622@2|Bacteria,46SPQ@74201|Verrucomicrobia,2IU8P@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Cytochrome C oxidase subunit II, periplasmic domain - - - - - - - - - - - - COX2 k59_442587_2 985255.APHJ01000021_gene1316 4.46e-10 61.2 COG0843@1|root,COG0843@2|Bacteria,4NEH8@976|Bacteroidetes,1HXYZ@117743|Flavobacteriia,2P643@244698|Gillisia 976|Bacteroidetes C Cytochrome C and Quinol oxidase polypeptide I coxN - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_10921_1 118005.AWNK01000010_gene274 3.25e-09 63.9 COG2304@1|root,COG2885@1|root,COG2304@2|Bacteria,COG2885@2|Bacteria 2|Bacteria M chlorophyll binding - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OmpA,VWA,VWA_2 k59_1325583_1 472759.Nhal_3219 2.44e-10 66.2 COG2303@1|root,COG2303@2|Bacteria,1MXUT@1224|Proteobacteria,1S03P@1236|Gammaproteobacteria 1236|Gammaproteobacteria E (GMC) oxidoreductase - - - - - - - - - - - - DAO,FAD_binding_2,FAD_binding_3,GMC_oxred_C,Pyr_redox_2 k59_1120406_1 285535.JOEY01000049_gene1405 1.64e-35 140.0 COG1506@1|root,COG1506@2|Bacteria,2H90U@201174|Actinobacteria 201174|Actinobacteria E Tannase and feruloyl esterase - - - - - - - - - - - - Tannase k59_754395_1 1379698.RBG1_1C00001G1666 2.39e-72 226.0 COG1136@1|root,COG1136@2|Bacteria,2NPA8@2323|unclassified Bacteria 2|Bacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1438267_1 69042.WH5701_03034 1.04e-42 153.0 COG0136@1|root,COG0136@2|Bacteria,1G0E6@1117|Cyanobacteria,1GYKG@1129|Synechococcus 1117|Cyanobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_10930_1 1323663.AROI01000003_gene2283 6.11e-31 122.0 COG0845@1|root,COG0845@2|Bacteria,1PDUT@1224|Proteobacteria,1RQKD@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - HlyD_3,HlyD_D23,OEP k59_82741_1 344747.PM8797T_27954 2.84e-59 199.0 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,PRiA4_ORF3,zf-IS66 k59_442629_1 1095772.CAHH01000073_gene545 2.19e-17 86.3 2AK27@1|root,31ARV@2|Bacteria,2IFAT@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1284478_1 50452.A0A087GKU4 4.87e-44 158.0 COG0483@1|root,KOG2951@2759|Eukaryota,37KZ5@33090|Viridiplantae,3GEZ2@35493|Streptophyta,3HPJX@3699|Brassicales 35493|Streptophyta G Bifunctional phosphatase IMPL2 - GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009507,GO:0009536,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052745,GO:0052803,GO:0052834,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,3.1.3.25,3.1.3.93 ko:K18649 ko00053,ko00340,ko00562,ko01100,ko01110,ko01230,ko04070,map00053,map00340,map00562,map01100,map01110,map01230,map04070 M00026,M00114,M00131 R01185,R01186,R01187,R03013,R07674 RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_442636_1 1002340.AFCF01000026_gene1385 1.86e-87 269.0 COG2128@1|root,COG2128@2|Bacteria 2|Bacteria S hydroperoxide reductase activity - - - - - - - - - - - - CMD,HWE_HK k59_285044_1 580332.Slit_0982 5.14e-84 266.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,44VCR@713636|Nitrosomonadales 28216|Betaproteobacteria V ABC transporter transmembrane region atm1 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_391153_1 1267535.KB906767_gene4838 1.15e-23 104.0 COG0457@1|root,COG3119@1|root,COG0457@2|Bacteria,COG3119@2|Bacteria 2|Bacteria P arylsulfatase activity - - - - - - - - - - - - Sulfatase,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_1068554_1 765869.BDW_05560 1.3e-10 67.8 COG4531@1|root,COG4531@2|Bacteria,1REHQ@1224|Proteobacteria,42TZ1@68525|delta/epsilon subdivisions,2MTGH@213481|Bdellovibrionales,2WQ6N@28221|Deltaproteobacteria 213481|Bdellovibrionales P ABC-type Zn2 transport system, periplasmic component surface adhesin - - - - - - - - - - - - - k59_1645297_1 159749.E7BWK5 2.05e-176 499.0 COG1333@1|root,2QRFF@2759|Eukaryota 2759|Eukaryota O cytochrome complex assembly ccs1 - - ko:K07399 - - - - ko00000 - - - ResB k59_859404_1 69328.PVLB_12500 4.75e-09 58.9 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,1RNY6@1236|Gammaproteobacteria 1236|Gammaproteobacteria C ATP ADP translocase - - - ko:K03301 - - - - ko00000 2.A.12 - - MFS_1,TLC k59_859404_2 1144275.COCOR_00424 1.02e-20 91.7 COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,4383U@68525|delta/epsilon subdivisions,2X3DT@28221|Deltaproteobacteria,2YVM7@29|Myxococcales 28221|Deltaproteobacteria S Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_498672_1 1123354.AUDR01000018_gene1159 3.2e-20 87.0 COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,2VU0P@28216|Betaproteobacteria,1KRV7@119069|Hydrogenophilales 119069|Hydrogenophilales U Preprotein translocase SecG subunit - - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_498672_2 1203606.HMPREF1526_02649 7.19e-05 44.3 COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,36DIA@31979|Clostridiaceae 186801|Clostridia G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - iHN637.CLJU_RS19265 TIM k59_391161_1 1185766.DL1_16695 9.25e-152 432.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,2XKI8@285107|Thioclava 28211|Alphaproteobacteria L Homeodomain-like domain - - - - - - - - - - - - HTH_32,rve,rve_3 k59_1120462_1 526225.Gobs_2761 6.28e-28 115.0 COG1018@1|root,COG2124@1|root,COG1018@2|Bacteria,COG2124@2|Bacteria,2GJCV@201174|Actinobacteria,4ETZ7@85013|Frankiales 201174|Actinobacteria C Oxidoreductase FAD-binding - - - - - - - - - - - - FAD_binding_6,Fer2,NAD_binding_1,p450 k59_129894_1 1463820.JOGW01000004_gene4520 6.13e-104 311.0 COG2141@1|root,COG2141@2|Bacteria,2GKP1@201174|Actinobacteria 201174|Actinobacteria C Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_1645305_1 754477.Q7C_1112 1.42e-26 105.0 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,1S9Z9@1236|Gammaproteobacteria,4618P@72273|Thiotrichales 72273|Thiotrichales C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_285999_1 1123253.AUBD01000005_gene294 2.64e-21 85.5 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,1SQDZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Homeodomain-like domain - - - - - - - - - - - - HTH_Tnp_1 k59_285999_2 1121377.KB906417_gene3861 9.35e-11 64.3 COG2801@1|root,COG2801@2|Bacteria 2|Bacteria L transposition - - - - - - - - - - - - HTH_21,rve,rve_3 k59_1230117_1 238854.Q5GQW5_BPSYP 1.78e-07 58.2 4QI3D@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1285717_1 753084.F4YCJ8_9CAUD 1.02e-38 133.0 4QAKE@10239|Viruses,4QUP7@35237|dsDNA viruses no RNA stage,4QPCE@28883|Caudovirales 28883|Caudovirales S endonuclease activity - - - - - - - - - - - - - k59_963816_2 349521.HCH_03939 3.46e-46 157.0 COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,1S3Y1@1236|Gammaproteobacteria,1XJ4Z@135619|Oceanospirillales 135619|Oceanospirillales S Bacterial transglutaminase-like cysteine proteinase BTLCP - - - - - - - - - - - - Peptidase_C93 k59_499863_1 1297742.A176_03348 6.11e-40 149.0 COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,42PU9@68525|delta/epsilon subdivisions,2WU8U@28221|Deltaproteobacteria,2Z2R6@29|Myxococcales 28221|Deltaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_815749_1 1045858.Bint_1721 0.000726 41.2 COG0848@1|root,COG0848@2|Bacteria,2J82R@203691|Spirochaetes 203691|Spirochaetes U PFAM Biopolymer transport protein ExbD TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_815749_2 414684.RC1_0800 2.25e-15 79.3 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,2TU50@28211|Alphaproteobacteria,2JSBB@204441|Rhodospirillales 204441|Rhodospirillales U MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_963825_1 1333507.AUTQ01000261_gene3788 1.42e-09 58.9 COG5587@1|root,COG5587@2|Bacteria,1R8B4@1224|Proteobacteria,1S1WW@1236|Gammaproteobacteria,2PZM5@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Conserved hypothetical protein (DUF2461) - - - - - - - - - - - - DUF2461 k59_963825_2 1002339.HMPREF9373_1162 4.74e-15 76.3 COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria,3NJPR@468|Moraxellaceae 1236|Gammaproteobacteria S Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes cpdA GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005488,GO:0005506,GO:0008081,GO:0008150,GO:0008198,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0042545,GO:0042578,GO:0043167,GO:0043169,GO:0045229,GO:0046872,GO:0046914,GO:0071554,GO:0071555,GO:0071840 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos k59_1646505_1 195253.Syn6312_0894 5.99e-21 90.9 COG0817@1|root,COG0817@2|Bacteria,1G6YP@1117|Cyanobacteria 1117|Cyanobacteria L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group - - - - - - - - - - - - - k59_1531816_1 314278.NB231_10158 1.32e-31 125.0 COG3637@1|root,COG3637@2|Bacteria,1R64D@1224|Proteobacteria,1S325@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Alginate export - - - - - - - - - - - - Alginate_exp k59_1326380_1 1540257.JQMW01000013_gene866 6.88e-28 113.0 COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia,36EHE@31979|Clostridiaceae 186801|Clostridia O Glycoprotease yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Acetyltransf_1,Peptidase_M22 k59_1169997_2 519989.ECTPHS_14156 2.33e-76 230.0 COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,1RSJY@1236|Gammaproteobacteria,1WY4B@135613|Chromatiales 135613|Chromatiales L PFAM Transposase - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_1016620_1 637905.SVI_3463 2.94e-05 52.4 COG1651@1|root,COG1651@2|Bacteria,1MY3H@1224|Proteobacteria,1S1X0@1236|Gammaproteobacteria,2QB68@267890|Shewanellaceae 1236|Gammaproteobacteria O PFAM DSBA oxidoreductase bdbD - - - - - - - - - - - DSBA,Thioredoxin_4 k59_1493329_1 1126627.BAWE01000002_gene690 3.25e-28 111.0 COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,2U1XJ@28211|Alphaproteobacteria,3JSHJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S hydrolase of the alpha beta-hydrolase fold - - - ko:K07020 - - - - ko00000 - - - Abhydrolase_6,DLH,Thioesterase k59_1531823_1 1246445.ANAY01000002_gene3512 1.91e-08 60.1 COG1309@1|root,COG1309@2|Bacteria,2GP59@201174|Actinobacteria,4EQ00@85012|Streptosporangiales 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1531823_2 1219035.NT2_08_00290 1.46e-11 65.1 COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2TRXY@28211|Alphaproteobacteria,2KDHV@204457|Sphingomonadales 204457|Sphingomonadales S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_286034_1 1288826.MSNKSG1_12787 1.08e-59 201.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RN7X@1236|Gammaproteobacteria,4665Q@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG1960 Acyl-CoA dehydrogenases aidB GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K09456 - - - - ko00000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_963845_1 243164.DET1508 1.63e-14 67.8 COG2963@1|root,COG2963@2|Bacteria,2GAW0@200795|Chloroflexi,34DGC@301297|Dehalococcoidia 301297|Dehalococcoidia L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_963845_2 314260.PB2503_12549 3.49e-67 211.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve,rve_3 k59_1230170_1 909663.KI867150_gene1577 6.65e-15 68.9 COG0828@1|root,COG0828@2|Bacteria,1MZA1@1224|Proteobacteria,42XSC@68525|delta/epsilon subdivisions,2WT18@28221|Deltaproteobacteria,2MSI8@213462|Syntrophobacterales 28221|Deltaproteobacteria J Ribosomal protein S21 rpsU GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 k59_1326395_1 269084.syc1395_c 4.45e-75 229.0 COG0783@1|root,COG0783@2|Bacteria,1G586@1117|Cyanobacteria,1H0B1@1129|Synechococcus 1117|Cyanobacteria P Belongs to the Dps family dps - - ko:K04047 - - - - ko00000,ko03036 - - - Ferritin k59_1326395_2 1515613.HQ37_04415 4.38e-24 100.0 COG0583@1|root,COG0583@2|Bacteria,4NGZ5@976|Bacteroidetes,2FNH6@200643|Bacteroidia,22X0D@171551|Porphyromonadaceae 976|Bacteroidetes K Transcriptional regulator oxyR - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_1439566_1 402881.Plav_0843 1.14e-19 92.4 COG1520@1|root,COG1520@2|Bacteria,1R4I1@1224|Proteobacteria,2U05B@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - k59_815782_1 228410.NE1153 3.63e-14 74.3 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2WEDQ@28216|Betaproteobacteria,37232@32003|Nitrosomonadales 28216|Betaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component oppB - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_815782_2 596152.DesU5LDRAFT_1026 5.96e-14 77.8 COG1216@1|root,COG1216@2|Bacteria,1R554@1224|Proteobacteria,435KX@68525|delta/epsilon subdivisions,2WZZC@28221|Deltaproteobacteria,2M92V@213115|Desulfovibrionales 28221|Deltaproteobacteria S Glycosyl transferase, family 2 - - - - - - - - - - - - - k59_1326396_1 32057.KB217478_gene590 9.13e-11 64.7 COG2085@1|root,COG2085@2|Bacteria,1G8DX@1117|Cyanobacteria 1117|Cyanobacteria S NADP oxidoreductase coenzyme F420-dependent - - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored k59_1646549_1 1123320.KB889629_gene7780 0.000818 42.4 COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria 201174|Actinobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_10 k59_1646549_2 234267.Acid_1428 9.34e-16 83.6 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria 57723|Acidobacteria KLTU WD40 domain protein beta Propeller - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase k59_131099_1 768671.ThimaDRAFT_3893 9.85e-102 319.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales 135613|Chromatiales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_1230180_1 6183.Smp_126020.1 8.19e-145 425.0 COG1838@1|root,2QT04@2759|Eukaryota,39WD1@33154|Opisthokonta,3BI53@33208|Metazoa,3D3TJ@33213|Bilateria 33208|Metazoa C Fumarase C-terminus - - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_912827_1 1232410.KI421412_gene40 3.42e-22 94.4 COG1463@1|root,COG1463@2|Bacteria,1Q6ZU@1224|Proteobacteria,42RZ3@68525|delta/epsilon subdivisions,2WNF0@28221|Deltaproteobacteria,43VBW@69541|Desulfuromonadales 28221|Deltaproteobacteria Q MlaD protein - - - ko:K06192 - - - - ko00000 - - - MlaD k59_912827_2 56780.SYN_02069 1e-46 158.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2WKHW@28221|Deltaproteobacteria,2MQ9V@213462|Syntrophobacterales 28221|Deltaproteobacteria Q ABC-type transport system involved in resistance to organic solvents, ATPase component - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_1531836_1 640081.Dsui_3398 1.78e-122 361.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,2KVNH@206389|Rhodocyclales 206389|Rhodocyclales L PFAM Integrase core domain - - - - - - - - - - - - HTH_38,rve k59_338318_1 472759.Nhal_3602 1.24e-46 159.0 COG1180@1|root,COG1180@2|Bacteria,1R8XY@1224|Proteobacteria,1T0C7@1236|Gammaproteobacteria,1X2MB@135613|Chromatiales 135613|Chromatiales O Radical SAM superfamily - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_705207_1 196367.JNFG01000051_gene1526 1.94e-27 104.0 COG2050@1|root,COG2050@2|Bacteria,1RGVP@1224|Proteobacteria,2VT4U@28216|Betaproteobacteria,1KHCJ@119060|Burkholderiaceae 28216|Betaproteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_705207_2 395493.BegalDRAFT_3013 3.12e-230 647.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Electron transfer flavoprotein-ubiquinone oxidoreductase etfD - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8,Thi4 k59_338319_1 290397.Adeh_2039 9.05e-67 221.0 COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,42ZD0@68525|delta/epsilon subdivisions,2WU4P@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation aceK - 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK k59_1439592_1 765912.Thimo_0057 5.15e-08 60.1 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1WWSM@135613|Chromatiales 135613|Chromatiales H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_1238157_1 59538.XP_005970420.1 6.77e-45 158.0 COG1282@1|root,2QQ0A@2759|Eukaryota,38CB0@33154|Opisthokonta,3BDQK@33208|Metazoa,3CWZ6@33213|Bilateria,4806D@7711|Chordata,494HY@7742|Vertebrata,3JARK@40674|Mammalia 33208|Metazoa C NAD(P)+ transhydrogenase (AB-specific) activity - - - - - - - - - - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB,PNTB_4TM k59_1238157_2 856793.MICA_1880 6.66e-23 92.4 COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,2UBXS@28211|Alphaproteobacteria,4BQHC@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C 4TM region of pyridine nucleotide transhydrogenase, mitoch pntAB GO:0008150,GO:0008152,GO:0055114 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB_4TM k59_552475_1 696747.NIES39_A04370 4.24e-68 224.0 COG0306@1|root,COG0306@2|Bacteria 2|Bacteria P phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_824718_1 1411685.U062_01976 1.68e-34 124.0 COG4319@1|root,COG4319@2|Bacteria,1R2QC@1224|Proteobacteria 1224|Proteobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_1238172_1 626522.GCWU000325_02828 1.15e-12 67.8 COG0534@1|root,COG0534@2|Bacteria,4NG7Q@976|Bacteroidetes,2FN68@200643|Bacteroidia,1WCZS@1283313|Alloprevotella 976|Bacteroidetes V MatE dinF - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_1238172_2 1448139.AI20_20310 1.21e-11 64.7 COG4539@1|root,COG4539@2|Bacteria,1N1G8@1224|Proteobacteria,1S9FD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane - - - - - - - - - - - - DUF962 k59_1537445_1 443143.GM18_0696 1.25e-34 123.0 COG0784@1|root,COG0784@2|Bacteria,1N017@1224|Proteobacteria,42UW8@68525|delta/epsilon subdivisions,2X7RN@28221|Deltaproteobacteria,43UXR@69541|Desulfuromonadales 28221|Deltaproteobacteria T response regulator - - - - - - - - - - - - Response_reg k59_668999_1 1110502.TMO_0118 1.59e-87 277.0 COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,2JZ17@204441|Rhodospirillales 204441|Rhodospirillales I COG1884 Methylmalonyl-CoA mutase, N-terminal domain subunit meaA - 5.4.99.63 ko:K14447 ko00630,ko01120,ko01200,map00630,map01120,map01200 M00373 R09292 RC02835 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase k59_1333050_1 268746.Q58MK8_BPPRM 3.94e-29 105.0 4QBEN@10239|Viruses,4QW43@35237|dsDNA viruses no RNA stage,4QPWZ@28883|Caudovirales,4QI7M@10662|Myoviridae 10662|Myoviridae S Protein of unknown function (DUF3110) - - - - - - - - - - - - - k59_1333050_2 268746.Q58MK9_BPPRM 2.26e-34 127.0 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales,4QHXI@10662|Myoviridae 10662|Myoviridae S hydrolase activity - - - - - - - - - - - - - k59_553494_1 1240349.ANGC01000049_gene3935 3.82e-16 76.6 COG0604@1|root,COG0604@2|Bacteria,2GKHW@201174|Actinobacteria,4FUTG@85025|Nocardiaceae 201174|Actinobacteria C NADPH quinone reductase qor - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_553494_2 279714.FuraDRAFT_3903 9.76e-14 69.3 2DQ77@1|root,3351E@2|Bacteria,1N9D8@1224|Proteobacteria,2VVUI@28216|Betaproteobacteria,2KRWH@206351|Neisseriales 206351|Neisseriales - - - - - - - - - - - - - - - k59_453222_1 1177928.TH2_05943 1.53e-137 409.0 COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,2TRUC@28211|Alphaproteobacteria,2JQP6@204441|Rhodospirillales 204441|Rhodospirillales T COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc k59_1388531_1 1129192.A0A0E3D9T0_9CAUD 3.52e-15 78.6 4QAIU@10239|Viruses,4QUQC@35237|dsDNA viruses no RNA stage,4QPDE@28883|Caudovirales,4QI6J@10662|Myoviridae 10662|Myoviridae S sequence-specific DNA binding transcription factor activity - - - - - - - - - - - - - k59_1295972_2 479431.Namu_4657 1.28e-13 75.1 COG1680@1|root,COG1680@2|Bacteria,2GNNF@201174|Actinobacteria 201174|Actinobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase,DUF3471 k59_1503546_1 1177154.Y5S_01704 1.71e-67 236.0 COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,1SEWA@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11,SdrD_B k59_1023680_1 56780.SYN_01567 2.9e-31 121.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,42NPG@68525|delta/epsilon subdivisions,2WJVP@28221|Deltaproteobacteria,2MREM@213462|Syntrophobacterales 28221|Deltaproteobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_1023680_2 459349.CLOAM1381 7.35e-38 140.0 COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,2NNYX@2323|unclassified Bacteria 2|Bacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis fabZ GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0019171 3.5.1.108,4.2.1.59 ko:K02372,ko:K02535,ko:K13599,ko:K16363 ko00061,ko00540,ko00780,ko01100,ko01212,ko02020,map00061,map00540,map00780,map01100,map01212,map02020 M00060,M00083,M00498,M00572 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005,ko02022 - - - FabA,LpxC k59_398575_2 1192868.CAIU01000008_gene873 8.18e-38 133.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2UGES@28211|Alphaproteobacteria,43P5X@69277|Phyllobacteriaceae 28211|Alphaproteobacteria J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_1333103_1 1396141.BATP01000029_gene2240 1.27e-32 130.0 COG3568@1|root,COG3568@2|Bacteria,46TP6@74201|Verrucomicrobia,2IV5G@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos,Phosphodiest k59_1239460_1 1429916.X566_12040 7.98e-62 210.0 COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,3JRT1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C CoA binding domain - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_1447154_1 1048983.EL17_13155 2.67e-07 52.0 COG1301@1|root,COG1301@2|Bacteria,4NDUU@976|Bacteroidetes,47KI1@768503|Cytophagia 976|Bacteroidetes C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltP - - - - - - - - - - - SDF k59_1447154_2 1237149.C900_02770 1.85e-51 177.0 COG1301@1|root,COG1301@2|Bacteria,4NDUU@976|Bacteroidetes,47KI1@768503|Cytophagia 976|Bacteroidetes C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltP - - - - - - - - - - - SDF k59_240593_1 228410.NE1486 2.82e-57 188.0 COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2VIVK@28216|Betaproteobacteria,3727J@32003|Nitrosomonadales 28216|Betaproteobacteria EH PFAM Aminotransferase, class IV dat - 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 k59_712631_1 330214.NIDE0623 1.31e-124 380.0 COG0653@1|root,COG0653@2|Bacteria,3J0E5@40117|Nitrospirae 40117|Nitrospirae U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_669082_1 1094980.Mpsy_0568 2.11e-36 137.0 COG5410@1|root,arCOG09550@2157|Archaea 2157|Archaea K chromosome segregation - - - - - - - - - - - - Terminase_6,Terminase_6C k59_867402_1 1123368.AUIS01000007_gene2749 2.68e-102 328.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,2NBUJ@225057|Acidithiobacillales 225057|Acidithiobacillales F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_1388576_1 296591.Bpro_2645 2.96e-99 295.0 COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2VQVG@28216|Betaproteobacteria,4AFGR@80864|Comamonadaceae 28216|Betaproteobacteria Q Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) arsM - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 k59_922238_1 330214.NIDE2267 1.88e-16 78.6 COG2204@1|root,COG2204@2|Bacteria,3J0ZU@40117|Nitrospirae 40117|Nitrospirae T Bacterial regulatory protein, Fis family - - - ko:K07715 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_922238_2 330214.NIDE2266 1.02e-65 212.0 COG2433@1|root,COG2433@2|Bacteria 2|Bacteria - - yttA - 2.7.13.3 ko:K07184,ko:K07777,ko:K12065,ko:K13527 ko02020,ko03050,map02020,map03050 M00342,M00478 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02044,ko03051 3.A.7.11.1 - - DUF3102,DUF3450 k59_453287_1 237368.SCABRO_01834 3.81e-45 164.0 COG0500@1|root,COG0535@1|root,COG0535@2|Bacteria,COG2226@2|Bacteria,2IYB6@203682|Planctomycetes 203682|Planctomycetes Q Methylase involved in ubiquinone menaquinone - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 k59_971229_1 1229909.NSED_09015 6.65e-98 307.0 COG1269@1|root,arCOG04138@2157|Archaea,41SRH@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_1239484_1 572477.Alvin_1293 1.82e-36 127.0 COG0347@1|root,COG0347@2|Bacteria,1RF4Q@1224|Proteobacteria,1S4F4@1236|Gammaproteobacteria,1WZ7Z@135613|Chromatiales 135613|Chromatiales K Belongs to the P(II) protein family - - - - - - - - - - - - P-II k59_1239484_2 1144325.PMI22_03225 3.9e-25 99.0 2DZHF@1|root,334VR@2|Bacteria,1NAZA@1224|Proteobacteria,1SF43@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_826204_1 395961.Cyan7425_1922 8.27e-28 107.0 COG1230@1|root,COG1230@2|Bacteria,1G4I5@1117|Cyanobacteria,3KJS2@43988|Cyanothece 1117|Cyanobacteria P Cation efflux protein - - - - - - - - - - - - Cation_efflux k59_1503600_2 1049564.TevJSym_be00220 2.25e-06 50.1 COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,1RSMW@1236|Gammaproteobacteria,1JB8I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_347218_1 378806.STAUR_6729 2.53e-27 108.0 COG2085@1|root,COG2085@2|Bacteria,1RCXR@1224|Proteobacteria,43070@68525|delta/epsilon subdivisions,2WVFX@28221|Deltaproteobacteria,2Z1E9@29|Myxococcales 28221|Deltaproteobacteria S NADP oxidoreductase coenzyme F420-dependent - - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored k59_1296043_1 1219045.BV98_003254 5.92e-26 104.0 COG0451@1|root,COG0451@2|Bacteria,1RGHF@1224|Proteobacteria,2VCZJ@28211|Alphaproteobacteria,2K3G1@204457|Sphingomonadales 204457|Sphingomonadales GM NAD dependent epimerase/dehydratase family - - - - - - - - - - - - Epimerase k59_1296043_2 1219035.NT2_01_05600 1.55e-12 69.3 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TTRR@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q cytochrome P450 - - - - - - - - - - - - p450 k59_971242_1 240015.ACP_2073 2.42e-23 103.0 COG0728@1|root,COG0728@2|Bacteria,3Y31G@57723|Acidobacteria,2JI21@204432|Acidobacteriia 204432|Acidobacteriia S virulence factor MVIN family protein - - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_140216_1 933262.AXAM01000022_gene3249 2.25e-05 45.4 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2WJSW@28221|Deltaproteobacteria,2MHMC@213118|Desulfobacterales 28221|Deltaproteobacteria G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_140216_2 1499967.BAYZ01000196_gene3073 1.01e-37 138.0 COG2379@1|root,COG2379@2|Bacteria,2NNQP@2323|unclassified Bacteria 2|Bacteria G MOFRL family ttuD - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_1130865_1 1219084.AP014508_gene1860 0.000192 48.9 COG0532@1|root,COG0532@2|Bacteria,2GCK1@200918|Thermotogae 200918|Thermotogae J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_1296054_1 443144.GM21_3293 7.48e-74 241.0 COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2WJG1@28221|Deltaproteobacteria,43TAK@69541|Desulfuromonadales 28221|Deltaproteobacteria A Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 k59_1656960_1 1049564.TevJSym_bc00360 7.23e-136 392.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,1RNTJ@1236|Gammaproteobacteria,1JB7M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NiFe/NiFeSe hydrogenase small subunit C-terminal - - 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_347243_1 472759.Nhal_1221 7.51e-13 68.2 COG5424@1|root,COG5424@2|Bacteria,1NQWN@1224|Proteobacteria,1SMYT@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ - - - - - - - - - - - - - k59_669126_2 631362.Thi970DRAFT_04565 8.85e-12 65.9 COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1WWAM@135613|Chromatiales 135613|Chromatiales H Uroporphyrinogen III synthase - - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 k59_605656_2 1121351.AUAP01000044_gene1280 3.48e-10 59.7 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2VIT9@28216|Betaproteobacteria,2KQ38@206351|Neisseriales 206351|Neisseriales E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_1333146_1 1049564.TevJSym_ap00660 2.6e-147 430.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1J55X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_3206 PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1503636_2 1045855.DSC_02050 3.49e-35 130.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1X3GI@135614|Xanthomonadales 135614|Xanthomonadales E highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_240638_1 349521.HCH_06223 1.13e-18 86.7 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1XH56@135619|Oceanospirillales 135619|Oceanospirillales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_240638_2 1469245.JFBG01000081_gene272 3.33e-15 70.1 COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,1S3WB@1236|Gammaproteobacteria,1WYAY@135613|Chromatiales 135613|Chromatiales J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL - - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_1598012_1 228399.appser1_4830 3.04e-20 91.7 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,1Y6QG@135625|Pasteurellales 135625|Pasteurellales E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metXA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1296069_1 589873.EP13_08515 6.05e-50 170.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,464VS@72275|Alteromonadaceae 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluC GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1598020_1 1095769.CAHF01000006_gene1914 3.78e-106 316.0 COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,472XC@75682|Oxalobacteraceae 28216|Betaproteobacteria H ThiF family thiF - 2.7.7.80,2.8.1.11 ko:K21029,ko:K21147 ko04122,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - Rhodanese,ThiF k59_826265_1 991905.SL003B_3341 2.14e-39 149.0 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,2TUBP@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_1503660_1 1227266.HMPREF1551_01363 0.000294 48.9 COG5263@1|root,COG5263@2|Bacteria,4NJ6B@976|Bacteroidetes,1IJ1I@117743|Flavobacteriia,1ETFV@1016|Capnocytophaga 976|Bacteroidetes S WG containing repeat - - - - - - - - - - - - WG_beta_rep k59_669157_1 373994.Riv7116_6444 8.82e-26 110.0 COG2072@1|root,COG2072@2|Bacteria,1G5HN@1117|Cyanobacteria,1HKP6@1161|Nostocales 1117|Cyanobacteria P flavoprotein involved in K transport - - 1.14.13.8 ko:K00485 ko00982,ko01120,map00982,map01120 - R08266 RC02233 ko00000,ko00001,ko01000 - - - FMO-like,K_oxygenase k59_1598023_1 1187851.A33M_2428 1.1e-05 48.1 COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,2TTJ5@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - NAD_binding_10,adh_short k59_669162_2 335543.Sfum_2263 1.01e-88 270.0 COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,42MTN@68525|delta/epsilon subdivisions,2WJAI@28221|Deltaproteobacteria,2MQUJ@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rmlA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_1538441_1 1268237.G114_18506 0.000249 48.9 COG0260@1|root,COG0260@2|Bacteria,1MXP6@1224|Proteobacteria,1RYKJ@1236|Gammaproteobacteria,1Y6IF@135624|Aeromonadales 135624|Aeromonadales E Belongs to the peptidase M17 family - - 3.4.11.1,3.4.11.5 ko:K01255,ko:K01259 ko00330,ko00480,ko01100,map00330,map00480,map01100 - R00135,R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17 k59_1078842_1 443143.GM18_0083 2.7e-68 218.0 COG2234@1|root,COG2234@2|Bacteria,1MXZS@1224|Proteobacteria,42S82@68525|delta/epsilon subdivisions,2WNUR@28221|Deltaproteobacteria,43TZW@69541|Desulfuromonadales 28221|Deltaproteobacteria S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 k59_553618_1 268746.Q58MM0_BPPRM 1.4e-54 183.0 4QHPV@10239|Viruses,4QWVT@35237|dsDNA viruses no RNA stage,4QTVP@28883|Caudovirales,4QICC@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_553618_2 445686.E3SL66_9CAUD 5.64e-31 120.0 4QAJ5@10239|Viruses,4QUS9@35237|dsDNA viruses no RNA stage,4QPY5@28883|Caudovirales,4QHUT@10662|Myoviridae 10662|Myoviridae S Major capsid protein Gp23 - GO:0005575,GO:0019012,GO:0019028,GO:0044423 - - - - - - - - - - - k59_510353_1 264462.Bd3594 2.59e-07 55.1 COG0625@1|root,COG0625@2|Bacteria,1PEUK@1224|Proteobacteria,437SY@68525|delta/epsilon subdivisions,2MUK6@213481|Bdellovibrionales,2X324@28221|Deltaproteobacteria 213481|Bdellovibrionales H Glutathione S-transferase, C-terminal domain - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N k59_140273_1 1430331.EP10_16710 5.59e-12 71.6 COG1821@1|root,COG1821@2|Bacteria 2|Bacteria GM Pfam ATP-grasp domain - - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_3,ATP-grasp_4,Acetyltransf_10 k59_562617_1 1117314.PCIT_10574 4.62e-72 241.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q0X3@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria V COG0841 Cation multidrug efflux pump - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1140587_1 1536773.R70331_15660 2.94e-10 66.2 COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,4HB1V@91061|Bacilli,26RFG@186822|Paenibacillaceae 91061|Bacilli EGP Permeases of the major facilitator superfamily blt - - ko:K08153 - M00717 - - ko00000,ko00002,ko02000 2.A.1.2.8 - - MFS_1,MFS_1_like,Sugar_tr k59_192418_1 909663.KI867150_gene333 6.17e-111 340.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MQB9@213462|Syntrophobacterales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane - - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SecA_DEAD,SecA_PP_bind k59_932012_1 472759.Nhal_3887 2.59e-49 178.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1WWYN@135613|Chromatiales 135613|Chromatiales U type IV pilus secretin PilQ - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_462272_1 1304885.AUEY01000006_gene717 2.79e-59 193.0 COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,42MNY@68525|delta/epsilon subdivisions,2WJ6C@28221|Deltaproteobacteria,2MI5J@213118|Desulfobacterales 28221|Deltaproteobacteria F CobB/CobQ-like glutamine amidotransferase domain purQ - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 k59_1140600_1 1301098.PKB_5087 1.77e-92 286.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria 1236|Gammaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_1032824_1 78245.Xaut_0214 6.1e-97 306.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2TSZ9@28211|Alphaproteobacteria,3EY7G@335928|Xanthobacteraceae 28211|Alphaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) MA20_17010 - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_1604999_1 765911.Thivi_1620 3.54e-29 115.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,1RRHA@1236|Gammaproteobacteria,1X1Z5@135613|Chromatiales 135613|Chromatiales O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_462279_1 1370122.JHXQ01000010_gene1455 1.92e-35 133.0 COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TU63@28211|Alphaproteobacteria,4BAN3@82115|Rhizobiaceae 28211|Alphaproteobacteria I Fatty acid hydroxylase superfamily MA20_18405 - - - - - - - - - - - FA_hydroxylase k59_1140617_2 436308.Nmar_0289 2.77e-93 275.0 COG0461@1|root,arCOG00029@2157|Archaea,41SJU@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_103563_1 748280.NH8B_2360 9.43e-80 258.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2VHBY@28216|Betaproteobacteria,2KSN0@206351|Neisseriales 206351|Neisseriales F asparagine - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_462298_1 34506.g3068 3.82e-16 82.4 2D1ZE@1|root,2SJVP@2759|Eukaryota,3AI9D@33154|Opisthokonta,3BX0X@33208|Metazoa,3DEMU@33213|Bilateria 33208|Metazoa S LppC putative lipoprotein - - - - - - - - - - - - LppC k59_562653_1 649638.Trad_0121 1.17e-98 300.0 COG0160@1|root,COG0160@2|Bacteria,1WJ8V@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.19,2.6.1.22 ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_148746_1 933262.AXAM01000069_gene2687 3.09e-47 173.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,2MIBK@213118|Desulfobacterales 28221|Deltaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1669954_1 268746.Q58MK9_BPPRM 1.85e-21 92.0 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales,4QHXI@10662|Myoviridae 10662|Myoviridae S hydrolase activity - - - - - - - - - - - - - k59_1669954_2 445686.E3SL73_9CAUD 1.86e-93 275.0 4QC5H@10239|Viruses,4QVHT@35237|dsDNA viruses no RNA stage,4QPNZ@28883|Caudovirales,4QHUK@10662|Myoviridae 10662|Myoviridae S sigma factor activity - - - - - - - - - - - - - k59_462315_1 1282876.BAOK01000002_gene894 1.21e-84 281.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_103589_1 1336243.JAEA01000013_gene3244 3.51e-15 73.2 COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,2U7H5@28211|Alphaproteobacteria,1JTC0@119045|Methylobacteriaceae 28211|Alphaproteobacteria M Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - - - - - - - - - - Fasciclin k59_103589_2 521674.Plim_3755 7.86e-54 184.0 COG3046@1|root,COG3046@2|Bacteria,2IY44@203682|Planctomycetes 203682|Planctomycetes S protein related to deoxyribodipyrimidine photolyase - - - ko:K06876 - - - - ko00000 - - - DPRP,FAD_binding_7 k59_1088425_1 582515.KR51_00028640 4.99e-18 89.4 COG3119@1|root,COG3119@2|Bacteria,1G35S@1117|Cyanobacteria 1117|Cyanobacteria P Arylsulfatase a - - - ko:K01138 - - - - ko00000,ko01000 - - - Sulfatase,Sulfatase_C k59_305005_1 1167006.UWK_01276 8.4e-41 154.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2MIS4@213118|Desulfobacterales 28221|Deltaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC pacL - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_1032881_1 1121403.AUCV01000026_gene2319 1.59e-30 120.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2WJ1G@28221|Deltaproteobacteria,2MHZQ@213118|Desulfobacterales 28221|Deltaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 k59_1547419_1 1382359.JIAL01000001_gene994 3.39e-66 219.0 COG0154@1|root,COG0154@2|Bacteria,3Y3E5@57723|Acidobacteria,2JISE@204432|Acidobacteriia 204432|Acidobacteriia J PFAM Amidase - - - - - - - - - - - - Amidase k59_876404_1 713586.KB900536_gene149 6.63e-79 245.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,1WWQK@135613|Chromatiales 135613|Chromatiales E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_249787_1 326442.PSHAa1010 4.35e-15 73.2 COG0789@1|root,COG0789@2|Bacteria,1RJD4@1224|Proteobacteria,1S8DH@1236|Gammaproteobacteria,2Q2A1@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR,MerR-DNA-bind,MerR_1 k59_192512_1 1206730.BAGA01000070_gene1683 9.19e-58 193.0 COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria,4FW2K@85025|Nocardiaceae 201174|Actinobacteria C CoA-transferase family III - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_249792_2 35754.JNYJ01000028_gene6084 1.53e-12 67.8 COG2078@1|root,COG2078@2|Bacteria,2ISCW@201174|Actinobacteria,4DJDH@85008|Micromonosporales 201174|Actinobacteria S AMMECR1 - - - ko:K06990 - - - - ko00000,ko04812 - - - AMMECR1,Memo k59_614607_1 400682.PAC_15704303 7.24e-157 460.0 COG0069@1|root,KOG0399@2759|Eukaryota,38E4E@33154|Opisthokonta,3BECM@33208|Metazoa 33208|Metazoa E glutamate synthase (NADH) activity. It is involved in the biological process described with oxidation-reduction process - - - - - - - - - - - - Fer4_20,GATase_2,Glu_syn_central,Glu_synthase,Pyr_redox_2 k59_771215_1 553385.JEMF01000021_gene3074 1.13e-09 58.2 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S5Y0@1236|Gammaproteobacteria,1XK0E@135619|Oceanospirillales 135619|Oceanospirillales Q TRAP-type mannitol chloroaromatic compound transport system, small permease component gtrA - - - - - - - - - - - DctQ k59_771215_2 1278309.KB907100_gene2322 2.76e-80 252.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1XHXR@135619|Oceanospirillales 135619|Oceanospirillales Q TRAP-type mannitol chloroaromatic compound transport system, large permease component gtrB - - - - - - - - - - - DctM k59_1248024_1 105559.Nwat_0766 5.75e-51 166.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1WYAE@135613|Chromatiales 135613|Chromatiales F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_1032910_1 671143.DAMO_2316 2.07e-31 119.0 COG0329@1|root,COG0329@2|Bacteria,2NP5Q@2323|unclassified Bacteria 2|Bacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_1032910_2 1144275.COCOR_06474 3.54e-41 147.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,42N84@68525|delta/epsilon subdivisions,2WJKT@28221|Deltaproteobacteria,2Z0A2@29|Myxococcales 28221|Deltaproteobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_1184873_1 1469245.JFBG01000086_gene1622 4.78e-104 324.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, chain G - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_932145_1 330214.NIDE1094 1.14e-32 130.0 COG0577@1|root,COG0577@2|Bacteria,3J0Z3@40117|Nitrospirae 40117|Nitrospirae V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_148820_2 330214.NIDE2414 1.46e-42 146.0 COG2062@1|root,COG2062@2|Bacteria 2|Bacteria T phosphohistidine phosphatase, SixA sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_721931_1 566466.NOR53_2675 1.27e-86 271.0 COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,1RP9M@1236|Gammaproteobacteria,1J8KH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_1140761_1 330214.NIDE0835 2.13e-113 341.0 COG0074@1|root,COG0372@1|root,COG0074@2|Bacteria,COG0372@2|Bacteria 2|Bacteria C Belongs to the citrate synthase family - - 2.3.3.8,6.2.1.5 ko:K01902,ko:K15230,ko:K15233 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00352,R00405,R01322,R02404 RC00004,RC00014,RC00067 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0306 Citrate_synt,CoA_binding,Ligase_CoA,Succ_CoA_lig k59_407734_1 857087.Metme_3848 1.31e-27 105.0 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,1XEYS@135618|Methylococcales 135618|Methylococcales S Belongs to the UPF0234 family - - - ko:K09767 - - - - ko00000 - - - DUF520 k59_407734_2 98439.AJLL01000087_gene3950 1.01e-09 58.5 COG0042@1|root,COG0042@2|Bacteria,1G0ME@1117|Cyanobacteria,1JJR2@1189|Stigonemataceae 1117|Cyanobacteria J Dihydrouridine synthase (Dus) dusA - - ko:K05539 - - - - ko00000,ko01000,ko03016 - - - Dus k59_978629_1 351348.Maqu_3303 5.28e-84 262.0 COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,1RN4G@1236|Gammaproteobacteria,466XK@72275|Alteromonadaceae 1236|Gammaproteobacteria C Glycolate oxidase FAD binding subunit glcE - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 k59_1605097_1 1370121.AUWS01000073_gene980 1.86e-54 180.0 COG1024@1|root,COG1024@2|Bacteria,2I9MZ@201174|Actinobacteria,233UG@1762|Mycobacteriaceae 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_932174_2 69395.JQLZ01000001_gene3113 1.92e-09 59.7 COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2TUAZ@28211|Alphaproteobacteria,2KFMD@204458|Caulobacterales 204458|Caulobacterales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1185998_1 330214.NIDE3198 4.28e-88 274.0 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_563886_1 1229909.NSED_09500 3.33e-106 322.0 COG0668@1|root,arCOG01568@2157|Archaea,41SYX@651137|Thaumarchaeota 651137|Thaumarchaeota M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_358181_1 1415780.JPOG01000001_gene64 6.92e-67 211.0 COG2258@1|root,COG2258@2|Bacteria,1RE2Q@1224|Proteobacteria,1SEFF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S MOSC domain - - - - - - - - - - - - - k59_463599_1 1238237.CP10139811_0487 7.97e-18 80.1 COG0290@1|root,COG0290@2|Bacteria 2|Bacteria J translation initiation factor activity infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_463599_2 526227.Mesil_0982 1.14e-06 51.2 COG0441@1|root,COG0441@2|Bacteria,1WI8Y@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_1548729_1 555779.Dthio_PD1005 3.92e-17 80.5 COG0346@1|root,COG0346@2|Bacteria,1PM7Y@1224|Proteobacteria,42RD3@68525|delta/epsilon subdivisions,2WNY7@28221|Deltaproteobacteria,2M92N@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_1605922_1 1336235.JAEG01000007_gene1530 2.12e-27 115.0 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,2TUBP@28211|Alphaproteobacteria,4B77J@82115|Rhizobiaceae 28211|Alphaproteobacteria S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_1605925_1 330214.NIDE0413 4.17e-94 280.0 2DQ3Q@1|root,334KX@2|Bacteria 2|Bacteria S Proto-chlorophyllide reductase 57 kd subunit bchB - - - - - - - - - - - PCP_red k59_1605930_1 436308.Nmar_0871 1.15e-84 262.0 COG0017@1|root,arCOG00406@2157|Archaea,41SBT@651137|Thaumarchaeota 651137|Thaumarchaeota J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) - - 6.1.1.23 ko:K09759 ko00970,map00970 M00360 R03647,R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_933361_1 765420.OSCT_1954 1.09e-43 147.0 COG0503@1|root,COG0503@2|Bacteria,2G8K9@200795|Chloroflexi,375M9@32061|Chloroflexia 32061|Chloroflexia F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k59_933361_2 95619.PM1_0217455 2.14e-28 114.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria 1236|Gammaproteobacteria K RNA polymerase sigma rpoS GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_193908_1 1519464.HY22_00255 7.5e-77 255.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - Sortilin-Vps10 k59_193914_1 518766.Rmar_2245 2.22e-52 187.0 COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,1FIMH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_306286_1 1394178.AWOO02000039_gene8625 5.65e-41 147.0 COG1024@1|root,COG1024@2|Bacteria,2I7QX@201174|Actinobacteria,4EHEV@85012|Streptosporangiales 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_251016_2 84531.JMTZ01000010_gene3207 4.7e-48 162.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1X30T@135614|Xanthomonadales 135614|Xanthomonadales D chromosome partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1089811_2 1469245.JFBG01000062_gene2270 9.99e-33 124.0 COG2358@1|root,COG2358@2|Bacteria 2|Bacteria G TRAP transporter, solute receptor (TAXI family MA20_27285 - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_1456375_1 329726.AM1_4855 1.03e-59 195.0 COG0190@1|root,COG0190@2|Bacteria,1G0FG@1117|Cyanobacteria 1117|Cyanobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_1456375_2 134676.ACPL_4517 2.66e-13 69.3 COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,4D98J@85008|Micromonosporales 201174|Actinobacteria E Glycine cleavage T-protein C-terminal barrel domain gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_1456377_1 1278307.KB906971_gene1413 2.21e-53 188.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,2QHSF@267894|Psychromonadaceae 1236|Gammaproteobacteria M Belongs to the peptidase S41A family prc GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - BAGE,DUF3340,PDZ,Peptidase_S41 k59_306299_1 1150469.RSPPHO_02811 3.33e-67 229.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria,2JPBE@204441|Rhodospirillales 204441|Rhodospirillales I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_723154_1 1492922.GY26_16345 3.88e-99 301.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1J4PB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases gltD GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iEC042_1314.EC042_3503,iYL1228.KPN_03625 Fer4_11,Fer4_20,Pyr_redox_2 k59_1199780_1 105559.Nwat_0192 3.13e-29 110.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1WYU5@135613|Chromatiales 135613|Chromatiales P PFAM Rhodanese domain protein - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_1199780_2 1026882.MAMP_01660 2.4e-95 281.0 COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,460FA@72273|Thiotrichales 72273|Thiotrichales L 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn - - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T k59_783114_1 247634.GPB2148_3291 1.9e-36 142.0 2B7EF@1|root,320I7@2|Bacteria,1NDV8@1224|Proteobacteria,1SG78@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1199805_1 316067.Geob_1477 1.85e-14 81.3 COG1215@1|root,COG1215@2|Bacteria,1RIJ7@1224|Proteobacteria,42WPQ@68525|delta/epsilon subdivisions,2WV8H@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1564942_1 857087.Metme_3027 2.17e-83 254.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1XDTQ@135618|Methylococcales 135618|Methylococcales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_25256_2 1496688.ER33_08780 1.58e-53 181.0 COG0489@1|root,COG0489@2|Bacteria,1G1I7@1117|Cyanobacteria,22S6C@167375|Cyanobium 1117|Cyanobacteria F Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_25274_1 765910.MARPU_10625 6.59e-51 182.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales 135613|Chromatiales K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_1615451_1 335543.Sfum_3645 2.93e-22 96.3 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,42SD9@68525|delta/epsilon subdivisions,2WPPN@28221|Deltaproteobacteria,2MQIZ@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3200 CTP_transf_like k59_1615451_2 1273103.NM10_07279 3.33e-20 85.1 COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,4H585@909932|Negativicutes 909932|Negativicutes J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_1355902_1 330214.NIDE1392 4.97e-98 305.0 COG0046@1|root,COG0046@2|Bacteria,3J0TJ@40117|Nitrospirae 40117|Nitrospirae F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,GATase_5 k59_1565153_1 420662.Mpe_A0906 1.13e-89 268.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,1KIXU@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Belongs to the GST superfamily - - 2.5.1.18 ko:K00799,ko:K11209 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N k59_25312_1 221988.MS1535 1.2e-60 197.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1Y7VV@135625|Pasteurellales 135625|Pasteurellales F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_1355957_1 1453501.JELR01000002_gene888 7.14e-89 290.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,464C0@72275|Alteromonadaceae 1236|Gammaproteobacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_1565213_1 446468.Ndas_0391 1.04e-49 176.0 COG0438@1|root,COG0438@2|Bacteria,2GMXE@201174|Actinobacteria,4EFZS@85012|Streptosporangiales 201174|Actinobacteria M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_1565213_2 298655.KI912266_gene1179 0.000173 45.4 COG0500@1|root,COG2226@2|Bacteria,2H38T@201174|Actinobacteria,4EU2T@85013|Frankiales 201174|Actinobacteria Q PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11 k59_1355970_1 1336208.JADY01000001_gene826 1.5e-26 106.0 COG2021@1|root,COG2021@2|Bacteria,1RDEH@1224|Proteobacteria,2U267@28211|Alphaproteobacteria,2JS8S@204441|Rhodospirillales 204441|Rhodospirillales E Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1355970_2 1071679.BG57_27985 1.88e-14 71.6 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VI82@28216|Betaproteobacteria,1K352@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM beta-lactamase domain protein - - - - - - - - - - - - Lactamase_B k59_25327_1 330214.NIDE1348 2.2e-85 263.0 COG4972@1|root,COG4972@2|Bacteria,3J177@40117|Nitrospirae 40117|Nitrospirae NU Type IV pilus assembly protein PilM; - - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_47989_1 566466.NOR53_347 3.43e-29 110.0 29CEM@1|root,2ZZD2@2|Bacteria,1RKJK@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_48192_2 1038859.AXAU01000026_gene2330 1.97e-31 121.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria,3JQQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_48225_1 1125863.JAFN01000001_gene952 5.96e-43 155.0 COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,42M93@68525|delta/epsilon subdivisions,2WK5I@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Transposase, IS204 IS1001 IS1096 IS1165 - - - ko:K07485 - - - - ko00000 - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_48326_2 1150626.PHAMO_80087 5.36e-17 85.5 COG3941@1|root,COG3941@2|Bacteria,1PHQP@1224|Proteobacteria,2V9RW@28211|Alphaproteobacteria,2JWSI@204441|Rhodospirillales 204441|Rhodospirillales S Lambda phage tail tape-measure protein (Tape_meas_lam_C) - - - - - - - - - - - - Tape_meas_lam_C k59_48348_1 330214.NIDE0248 2.11e-20 86.7 2EC6I@1|root,33651@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - PsiE k59_48348_3 330214.NIDE0250 4.17e-78 248.0 COG0531@1|root,COG0531@2|Bacteria,3J0ZY@40117|Nitrospirae 40117|Nitrospirae E Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_48393_1 485913.Krac_1190 8.85e-50 172.0 COG0151@1|root,COG0151@2|Bacteria,2G7M4@200795|Chloroflexi 200795|Chloroflexi F carboxylate-amine ligase domain protein - - - - - - - - - - - - ATP-grasp_4 k59_48487_1 1499967.BAYZ01000069_gene1871 0.000631 43.1 COG1366@1|root,COG1366@2|Bacteria 2|Bacteria T antisigma factor binding - - - ko:K04749 - - - - ko00000,ko03021 - - - STAS k59_48604_1 1123253.AUBD01000004_gene1130 1.09e-24 104.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1X39P@135614|Xanthomonadales 135614|Xanthomonadales P Ammonium transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_48619_1 189426.PODO_20825 3.52e-73 235.0 COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,4H9ZF@91061|Bacilli,26QJT@186822|Paenibacillaceae 91061|Bacilli C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_48657_2 1459636.NTE_03028 5.12e-17 77.8 COG2146@1|root,arCOG02852@2157|Archaea 2157|Archaea P COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske k59_48659_1 1429046.RR21198_4455 0.000359 42.7 COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4FWYQ@85025|Nocardiaceae 201174|Actinobacteria T Transcriptional regulatory protein, C terminal phoP - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_48659_2 1131269.AQVV01000001_gene1303 6.75e-30 120.0 COG5000@1|root,COG5000@2|Bacteria 2|Bacteria T phosphorelay sensor kinase activity ntrY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_48754_1 869210.Marky_1372 3.99e-17 81.3 COG0557@1|root,COG0557@2|Bacteria,1WIKR@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus K ribonuclease II - - 3.1.13.1 ko:K01147 - - - - ko00000,ko01000,ko03016 - - - RNB k59_48754_2 1469245.JFBG01000002_gene447 2.71e-17 89.4 COG0810@1|root,COG0810@2|Bacteria 2|Bacteria M energy transducer activity tolA - - ko:K03646,ko:K03832 - - - - ko00000,ko02000 2.C.1.1,2.C.1.2 - - TonB_2 k59_48959_1 867903.ThesuDRAFT_02169 2.31e-41 154.0 COG1351@1|root,COG1351@2|Bacteria 2|Bacteria F thymidylate synthase (FAD) activity thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_49002_2 1161401.ASJA01000002_gene2666 2.67e-65 214.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2TQNE@28211|Alphaproteobacteria,43WHZ@69657|Hyphomonadaceae 28211|Alphaproteobacteria H Belongs to the prokaryotic GSH synthase family gshB GO:0003674,GO:0003824,GO:0004363,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_49015_3 143224.JQMD01000002_gene3379 3.6e-14 72.4 28II1@1|root,2Z8J7@2|Bacteria,4NFJH@976|Bacteroidetes,1HXNM@117743|Flavobacteriia 976|Bacteroidetes S SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD_RagB k59_49093_1 330214.NIDE3289 2.96e-81 252.0 COG0343@1|root,COG0343@2|Bacteria,3J0DU@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_49141_2 330214.NIDE1221 9.55e-32 115.0 2EAFJ@1|root,334IY@2|Bacteria 2|Bacteria S Domain of unknown function (DUF1844) - - - - - - - - - - - - DUF1844 k59_49146_2 1100720.ALKN01000034_gene568 8.02e-35 126.0 COG0745@1|root,COG0745@2|Bacteria,1N7TJ@1224|Proteobacteria,2WF9N@28216|Betaproteobacteria,4AJRU@80864|Comamonadaceae 28216|Betaproteobacteria T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_49202_1 441620.Mpop_3787 3.82e-44 153.0 2BZ0R@1|root,2Z7U0@2|Bacteria,1MX37@1224|Proteobacteria,2TSBD@28211|Alphaproteobacteria,1JTQG@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM Nitrile hydratase alpha chain nthA - 4.2.1.84 ko:K01721,ko:K20807 ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120 - R02828,R04020,R05379,R05596,R07780,R07854 RC00483,RC00792,RC01345,RC01432 ko00000,ko00001,ko01000 - - - NHase_alpha k59_49467_1 1121937.AUHJ01000005_gene2245 1.53e-89 275.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RNG4@1236|Gammaproteobacteria,46CMR@72275|Alteromonadaceae 1236|Gammaproteobacteria M DegT/DnrJ/EryC1/StrS aminotransferase family ddhC - 1.17.1.1 ko:K12452 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - DegT_DnrJ_EryC1 k59_49609_2 1178482.BJB45_15130 8.22e-06 47.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1XI0C@135619|Oceanospirillales 135619|Oceanospirillales H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_49663_1 96561.Dole_0855 1.69e-109 340.0 COG0490@1|root,COG1226@1|root,COG4651@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WK23@28221|Deltaproteobacteria,2MHVK@213118|Desulfobacterales 28221|Deltaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.2 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_49707_1 1265505.ATUG01000003_gene888 5.41e-16 77.8 COG0683@1|root,COG0683@2|Bacteria,1MVV2@1224|Proteobacteria,42T8J@68525|delta/epsilon subdivisions,2WPMX@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_49754_2 1096930.L284_03450 1.1e-12 67.4 COG4566@1|root,COG4566@2|Bacteria,1R47Z@1224|Proteobacteria,2TSQS@28211|Alphaproteobacteria,2K3TI@204457|Sphingomonadales 204457|Sphingomonadales K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_49866_1 1123070.KB899261_gene2111 3.74e-50 177.0 COG1413@1|root,COG3119@1|root,COG1413@2|Bacteria,COG3119@2|Bacteria,46TXU@74201|Verrucomicrobia,2IV3I@203494|Verrucomicrobiae 203494|Verrucomicrobiae CP Sulfatase - - - - - - - - - - - - Sulfatase k59_50083_1 348824.LPU83_1748 1.76e-06 54.7 2AURD@1|root,31KEC@2|Bacteria,1RJGV@1224|Proteobacteria,2UA1Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - NT5C k59_50169_1 477228.YO5_20077 3.15e-17 83.2 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1Z06K@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048 Formyl_trans_C,Formyl_trans_N k59_50174_1 314285.KT71_09797 8.64e-23 97.8 COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria,1J5H3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Carbamoyltransferase C-terminus - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_50174_2 1123059.KB823011_gene1545 1.53e-21 93.2 COG0500@1|root,COG0500@2|Bacteria,1QUSR@1224|Proteobacteria 1224|Proteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_23 k59_50689_1 1499967.BAYZ01000028_gene1275 3.87e-91 283.0 COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria 2|Bacteria O smart pdz dhr glgf - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_50864_1 1123355.JHYO01000034_gene557 7.13e-24 102.0 COG2010@1|root,COG4447@1|root,COG2010@2|Bacteria,COG4447@2|Bacteria,1NEFN@1224|Proteobacteria,2UHRQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome c - - - - - - - - - - - - - k59_50898_1 1380387.JADM01000012_gene1514 1.66e-58 202.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1XHNV@135619|Oceanospirillales 135619|Oceanospirillales C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_50964_1 1304883.KI912532_gene2101 9.09e-23 89.7 COG2863@1|root,COG2863@2|Bacteria,1N1DQ@1224|Proteobacteria,2VTXW@28216|Betaproteobacteria,2KZ0R@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome C oxidase, cbb3-type, subunit III - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_50964_2 1454004.AW11_03009 1.71e-40 141.0 COG2863@1|root,COG2863@2|Bacteria,1R6DK@1224|Proteobacteria,2VNV6@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrom_C k59_51025_2 436308.Nmar_0843 1.8e-61 194.0 COG1208@1|root,arCOG00663@2157|Archaea,41SIU@651137|Thaumarchaeota 651137|Thaumarchaeota M Nucleotidyl transferase - - - - - - - - - - - - NTP_transferase k59_51037_1 290397.Adeh_0203 5.67e-101 312.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,42NA6@68525|delta/epsilon subdivisions,2WIMU@28221|Deltaproteobacteria,2YU9T@29|Myxococcales 28221|Deltaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_1416500_1 365528.KB891103_gene3825 5.12e-64 209.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria 201174|Actinobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_1416503_1 330214.NIDE0611 8.14e-119 350.0 COG1894@1|root,COG1894@2|Bacteria,3J0WX@40117|Nitrospirae 40117|Nitrospirae C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region - - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_371751_2 323261.Noc_1219 1.09e-76 237.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1RPMP@1236|Gammaproteobacteria,1WYSG@135613|Chromatiales 135613|Chromatiales M FKBP-type peptidyl-prolyl isomerase - - 5.2.1.8 ko:K03773 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N k59_1311879_2 1235279.C772_01629 1.1e-08 60.8 COG4956@1|root,COG4956@2|Bacteria,1TP0P@1239|Firmicutes,4H9NQ@91061|Bacilli,26E3V@186818|Planococcaceae 91061|Bacilli S COG4956 Integral membrane protein (PIN domain superfamily) yacL GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - - - - - - - - - - TRAM k59_841939_1 472759.Nhal_2509 3.15e-97 302.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,1RPGT@1236|Gammaproteobacteria,1WW8N@135613|Chromatiales 135613|Chromatiales I Acetoacetyl-CoA synthase - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_634585_1 671143.DAMO_1980 2.11e-85 272.0 COG3170@1|root,COG3170@2|Bacteria,2NPXD@2323|unclassified Bacteria 2|Bacteria NU Tfp pilus assembly protein FimV - - - - - - - - - - - - - k59_945930_1 1286631.X805_12100 6.28e-23 110.0 COG1073@1|root,COG1073@2|Bacteria,1R9V1@1224|Proteobacteria,2VTA9@28216|Betaproteobacteria,1KNTQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria S alpha beta - - - - - - - - - - - - - k59_791164_1 1278073.MYSTI_06362 1.74e-07 53.9 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria,2YUJQ@29|Myxococcales 28221|Deltaproteobacteria NU pilus assembly protein pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_791164_2 398767.Glov_1639 1.87e-18 79.0 COG1476@1|root,COG1476@2|Bacteria,1NB6T@1224|Proteobacteria,42VWK@68525|delta/epsilon subdivisions,2WRMY@28221|Deltaproteobacteria,43VV4@69541|Desulfuromonadales 28221|Deltaproteobacteria K PFAM helix-turn-helix domain protein - - - - - - - - - - - - HTH_3 k59_791164_3 391625.PPSIR1_35422 1.17e-30 121.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YTY9@29|Myxococcales 28221|Deltaproteobacteria T response regulator - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_945933_1 357808.RoseRS_0064 9.27e-54 191.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2G5Y6@200795|Chloroflexi,37508@32061|Chloroflexia 32061|Chloroflexia H Vitamin B12 dependent methionine synthase activation region - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_841955_1 688245.CtCNB1_0796 1.13e-33 134.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria,4A9ZQ@80864|Comamonadaceae 28216|Betaproteobacteria H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_945939_1 243233.MCA2773 1.04e-38 138.0 COG0212@1|root,COG0212@2|Bacteria,1PR68@1224|Proteobacteria,1SWUW@1236|Gammaproteobacteria,1XF1W@135618|Methylococcales 135618|Methylococcales H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig k59_424051_1 472759.Nhal_0669 1.41e-92 285.0 COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,1RPU2@1236|Gammaproteobacteria,1WWU8@135613|Chromatiales 135613|Chromatiales S SpoVR family - - - ko:K06415 - - - - ko00000 - - - SpoVR k59_424051_2 85643.Tmz1t_1266 3.59e-18 84.3 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,2VKWB@28216|Betaproteobacteria,2KVQ3@206389|Rhodocyclales 206389|Rhodocyclales J COG0480 Translation elongation factors (GTPases) - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_1103253_1 557599.MKAN_22740 2.52e-30 120.0 COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,234SQ@1762|Mycobacteriaceae 201174|Actinobacteria C F420-dependent oxidoreductase, Rv2161c - - - - - - - - - - - - Bac_luciferase k59_1625421_1 463191.SSEG_09534 4.81e-61 201.0 COG2141@1|root,COG2141@2|Bacteria,2GNQ1@201174|Actinobacteria 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_60015_1 395493.BegalDRAFT_0696 2.77e-33 124.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,460C1@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_60015_2 519989.ECTPHS_03769 6.17e-102 300.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1WVVN@135613|Chromatiales 135613|Chromatiales EH TIGRFAM glutamine amidotransferase of anthranilate synthase - - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_1416533_1 472759.Nhal_2058 3.94e-73 237.0 COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,1RRIA@1236|Gammaproteobacteria,1X0CC@135613|Chromatiales 135613|Chromatiales E 7 transmembrane helices usually fused to an inactive transglutaminase - - - - - - - - - - - - 7TM_transglut,Transglut_i_TM k59_945948_1 1193181.BN10_580037 8.61e-55 193.0 COG3696@1|root,COG3696@2|Bacteria,2I53X@201174|Actinobacteria,4FK2M@85021|Intrasporangiaceae 201174|Actinobacteria P AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_1469521_1 1229909.NSED_02730 3.35e-62 201.0 COG0351@1|root,arCOG00020@2157|Archaea,41SA1@651137|Thaumarchaeota 651137|Thaumarchaeota H Phosphomethylpyrimidine kinase - - 2.5.1.3,2.7.1.49,2.7.4.7 ko:K21219 ko00730,ko01100,map00730,map01100 - R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko01000 - - - Phos_pyr_kin,ThiP_synth k59_634625_1 1041142.ATTP01000039_gene4747 4.12e-19 87.4 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TUMK@28211|Alphaproteobacteria,4B9FV@82115|Rhizobiaceae 28211|Alphaproteobacteria E oxidoreductase - - - - - - - - - - - - DAO k59_634625_2 279714.FuraDRAFT_1484 2.46e-16 75.5 COG0625@1|root,COG0625@2|Bacteria,1RK1K@1224|Proteobacteria,2WEV9@28216|Betaproteobacteria 28216|Betaproteobacteria O Glutathione S-transferase, C-terminal domain - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N_3 k59_3187_1 1280946.HY29_01150 1.04e-18 86.3 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 k59_3187_2 485918.Cpin_1253 2.5e-05 48.5 COG0739@1|root,COG0739@2|Bacteria,4NN4Q@976|Bacteroidetes,1ISDJ@117747|Sphingobacteriia 976|Bacteroidetes M PFAM Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_791197_1 926556.Echvi_1154 6.58e-71 223.0 COG0744@1|root,COG0744@2|Bacteria,4NF90@976|Bacteroidetes,47MHF@768503|Cytophagia 976|Bacteroidetes M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_1209319_1 671143.DAMO_0264 1.28e-43 157.0 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2NP0Q@2323|unclassified Bacteria 2|Bacteria M Bacterial sugar transferase wcaJ - - ko:K03606,ko:K20997 ko02025,ko05111,map02025,map05111 - - - ko00000,ko00001 - - - Bac_transf,CoA_binding_3 k59_528346_1 566466.NOR53_882 4.07e-43 144.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria,1J5ZB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the universal ribosomal protein uS9 family rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_528346_2 351348.Maqu_2472 7.25e-67 208.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,466GF@72275|Alteromonadaceae 1236|Gammaproteobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_1625442_1 338969.Rfer_2801 1.34e-23 94.0 COG0346@1|root,COG0346@2|Bacteria,1RA9H@1224|Proteobacteria,2VQ0D@28216|Betaproteobacteria,4ADFN@80864|Comamonadaceae 28216|Betaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase_4 k59_1625442_2 483219.LILAB_01350 9.97e-86 271.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,42MRJ@68525|delta/epsilon subdivisions,2WITA@28221|Deltaproteobacteria,2YUDC@29|Myxococcales 28221|Deltaproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_1261416_1 439235.Dalk_0804 8.96e-80 256.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2MHTP@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1276 CTP_synth_N,GATase k59_1103279_1 1120705.FG95_02824 5.49e-42 157.0 COG2244@1|root,COG2244@2|Bacteria,1R9I0@1224|Proteobacteria,2U3NB@28211|Alphaproteobacteria,2K0X3@204457|Sphingomonadales 204457|Sphingomonadales S Membrane protein involved in the export of O-antigen and teichoic acid - - - - - - - - - - - - Polysacc_synt_3,Polysacc_synt_C k59_737444_1 1249634.D781_1282 2.48e-73 232.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,401TN@613|Serratia 1236|Gammaproteobacteria F Belongs to the D-alanine--D-alanine ligase family ddl GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iAF1260.b0381,iB21_1397.B21_00332,iBWG_1329.BWG_0265,iE2348C_1286.E2348C_0317,iEC042_1314.EC042_0413,iEC55989_1330.EC55989_0386,iECBD_1354.ECBD_3283,iECB_1328.ECB_00328,iECDH10B_1368.ECDH10B_0338,iECDH1ME8569_1439.ECDH1ME8569_0367,iECD_1391.ECD_00328,iECH74115_1262.ECH74115_0453,iECIAI1_1343.ECIAI1_0377,iECIAI39_1322.ECIAI39_0301,iECO103_1326.ECO103_0356,iECO111_1330.ECO111_0411,iECO26_1355.ECO26_0414,iECSE_1348.ECSE_0401,iECSP_1301.ECSP_0441,iECs_1301.ECs0431,iETEC_1333.ETEC_0434,iEcDH1_1363.EcDH1_3227,iEcE24377_1341.EcE24377A_0406,iEcHS_1320.EcHS_A0447,iEcSMS35_1347.EcSMS35_0410,iEcolC_1368.EcolC_3251,iJO1366.b0381,iJR904.b0381,iSF_1195.SF0232,iSFxv_1172.SFxv_0245,iS_1188.S0254,iUMNK88_1353.UMNK88_429,iY75_1357.Y75_RS01965,iZ_1308.Z0477 Dala_Dala_lig_C,Dala_Dala_lig_N k59_686734_1 631362.Thi970DRAFT_02157 1.58e-89 278.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1WWU2@135613|Chromatiales 135613|Chromatiales E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_634642_1 323261.Noc_2795 7.38e-10 58.2 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,1S668@1236|Gammaproteobacteria,1WYAA@135613|Chromatiales 135613|Chromatiales G PTS IIA-like nitrogen-regulatory protein PtsN - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_634642_2 2340.JV46_25920 1.8e-95 293.0 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,1S02U@1236|Gammaproteobacteria,1J7PM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_634642_3 1122201.AUAZ01000047_gene2146 9.52e-94 285.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,464DI@72275|Alteromonadaceae 1236|Gammaproteobacteria S Displays ATPase and GTPase activities rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_634642_4 290633.GOX0814 2.15e-15 75.1 COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2U9E5@28211|Alphaproteobacteria,2JS9V@204441|Rhodospirillales 204441|Rhodospirillales G COG2893 Phosphotransferase system, mannose fructose-specific component IIA manX - 2.7.1.191 ko:K02793 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1 - - EIIA-man k59_791222_1 1121013.P873_02600 2.72e-36 142.0 COG5360@1|root,COG5360@2|Bacteria,1MUJ4@1224|Proteobacteria,1RR5T@1236|Gammaproteobacteria,1XA3C@135614|Xanthomonadales 135614|Xanthomonadales S Heparinase II/III N-terminus - - - - - - - - - - - - Hepar_II_III,Hepar_II_III_N k59_320114_1 436308.Nmar_0537 2.9e-163 467.0 COG3635@1|root,arCOG01696@2157|Archaea,41S6M@651137|Thaumarchaeota 651137|Thaumarchaeota G phosphoglycerate mutase - - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase k59_1209351_1 331869.BAL199_27965 1.69e-124 365.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,2TRU3@28211|Alphaproteobacteria,4BSXV@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_1209351_2 1122135.KB893166_gene3092 1.22e-38 139.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_1364369_1 1210884.HG799465_gene11512 1.43e-97 329.0 COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,2J2GD@203682|Planctomycetes 203682|Planctomycetes KLT AAA ATPase domain - - - - - - - - - - - - AAA_16,Pkinase k59_1625466_1 292415.Tbd_0071 1.5e-117 347.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VJD9@28216|Betaproteobacteria,1KSZD@119069|Hydrogenophilales 119069|Hydrogenophilales C 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Radical_SAM k59_1625466_2 1163617.SCD_n00375 3.85e-70 216.0 COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,2VR9X@28216|Betaproteobacteria 28216|Betaproteobacteria K transcriptional regulator AsnC family nirH - - - - - - - - - - - HTH_AsnC-type k59_320121_1 314230.DSM3645_07181 1.01e-32 118.0 COG3288@1|root,COG3288@2|Bacteria,2J0SW@203682|Planctomycetes 203682|Planctomycetes C COG3288 NAD NADP transhydrogenase alpha subunit - - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB_4TM k59_320121_2 393595.ABO_1327 7.71e-15 74.7 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1XH9D@135619|Oceanospirillales 135619|Oceanospirillales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_738181_1 395493.BegalDRAFT_2979 1.66e-06 49.3 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,45ZSX@72273|Thiotrichales 72273|Thiotrichales NU Type II IV secretion system protein pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_738181_2 472759.Nhal_3848 5.06e-55 184.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,1WWAB@135613|Chromatiales 135613|Chromatiales U Type II secretion system - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_529136_1 765910.MARPU_15110 2.26e-103 314.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales 135613|Chromatiales J Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_372599_1 330214.NIDE1947 2.02e-40 153.0 COG3210@1|root,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - - - - - - - - - - - Haemagg_act k59_1626255_1 1493511.A0A0E3I187_9CAUD 4.77e-59 203.0 4QB1D@10239|Viruses,4QPED@28883|Caudovirales,4QI2Z@10662|Myoviridae 10662|Myoviridae S Bacteriophage T4, Gp8 - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098025 - - - - - - - - - - - k59_895356_1 1121272.KB903249_gene2267 3.99e-36 140.0 28IUR@1|root,2Z8TE@2|Bacteria,2I9P5@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_161662_1 330214.NIDE1303 1.25e-96 311.0 COG0085@1|root,COG0085@2|Bacteria,3J0CW@40117|Nitrospirae 40117|Nitrospirae K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_215863_1 1219035.NT2_09_01030 2.22e-78 252.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2K9T4@204457|Sphingomonadales 204457|Sphingomonadales IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_110907_1 1288298.rosmuc_00758 5.32e-91 273.0 COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2TTMB@28211|Alphaproteobacteria,46QD9@74030|Roseovarius 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase Echdc - - - - - - - - - - - ECH_1 k59_215870_1 436308.Nmar_0502 1.48e-42 140.0 arCOG08761@1|root,arCOG08761@2157|Archaea,41T5T@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_215870_2 436308.Nmar_0501 8.03e-68 210.0 COG0671@1|root,arCOG03056@2157|Archaea,41SQ8@651137|Thaumarchaeota 651137|Thaumarchaeota I Acid phosphatase homologues - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2 k59_1519563_1 497964.CfE428DRAFT_4093 2.48e-125 392.0 COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,46SAP@74201|Verrucomicrobia 74201|Verrucomicrobia CE Proline dehydrogenase - - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_1210364_1 1187851.A33M_2935 1.25e-75 229.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U5BM@28211|Alphaproteobacteria,3FE4J@34008|Rhodovulum 28211|Alphaproteobacteria C [2Fe-2S] binding domain MA20_09390 - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 k59_1104298_1 648885.KB316282_gene2125 1.44e-50 165.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,1JTSW@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_21,rve,rve_3 k59_738206_1 1123070.KB899256_gene2181 4.18e-82 263.0 COG0112@1|root,COG0112@2|Bacteria,46S5I@74201|Verrucomicrobia,2ITI6@203494|Verrucomicrobiae 203494|Verrucomicrobiae E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism - - - - - - - - - - - - LMWPc,LacAB_rpiB,SHMT k59_635695_1 1540221.JQNI01000002_gene1028 8.49e-25 103.0 COG2301@1|root,COG2301@2|Bacteria 2|Bacteria G Belongs to the HpcH HpaI aldolase family citE GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006107,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046872,GO:0071704 4.1.3.25,4.1.3.34 ko:K01644,ko:K18292 ko00660,ko01100,ko02020,map00660,map01100,map02020 - R00237,R00362 RC00067,RC00502,RC01118,RC01205 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_635695_2 1510531.JQJJ01000009_gene583 7.1e-26 104.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR15@28211|Alphaproteobacteria,3JQQB@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain MA20_22975 - - ko:K11731 ko00281,map00281 - R08089 RC01893 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_268446_1 330214.NIDE0330 2.39e-34 125.0 COG2928@1|root,COG2928@2|Bacteria,3J0R2@40117|Nitrospirae 40117|Nitrospirae S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_1262504_1 1380394.JADL01000001_gene2525 1.03e-33 134.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,2TS2A@28211|Alphaproteobacteria,2JVIJ@204441|Rhodospirillales 204441|Rhodospirillales S CHAT domain - - - - - - - - - - - - CHAT k59_372640_1 717231.Flexsi_0826 3.76e-41 138.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein ectC - 4.2.1.108 ko:K06720 ko00260,ko01100,ko01120,map00260,map01100,map01120 M00033 R06979 RC01729 ko00000,ko00001,ko00002,ko01000 - - - Ectoine_synth k59_372640_2 640081.Dsui_1632 2.39e-23 96.7 COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,2VTYE@28216|Betaproteobacteria,2KX1A@206389|Rhodocyclales 206389|Rhodocyclales S FixH family - - - ko:K09926 - - - - ko00000 - - - FixH k59_372640_3 1397527.Q670_08855 1.42e-33 130.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1XI7X@135619|Oceanospirillales 135619|Oceanospirillales C COG0348 Polyferredoxin - - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_378388_1 323261.Noc_0914 1.58e-23 97.4 COG0500@1|root,COG2226@2|Bacteria,1MVIS@1224|Proteobacteria,1S5K2@1236|Gammaproteobacteria,1X0P5@135613|Chromatiales 135613|Chromatiales Q Methyltransferase type 11 - - 2.1.1.17,2.1.1.71 ko:K00570 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00091 R01320,R02056,R03424 RC00003,RC00060,RC00181,RC00496 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_1057322_1 709797.CSIRO_2259 7.71e-27 108.0 COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,3JT1Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EG Belongs to the IlvD Edd family MA20_16960 - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_1109561_1 85643.Tmz1t_2948 1.94e-13 69.7 COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,2VSQQ@28216|Betaproteobacteria,2KXX8@206389|Rhodocyclales 206389|Rhodocyclales I BadF/BadG/BcrA/BcrD ATPase family - - 1.3.7.8 ko:K04115 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - BcrAD_BadFG k59_1109561_2 311424.DhcVS_179 1.13e-19 82.4 COG1145@1|root,COG1145@2|Bacteria,2GAVM@200795|Chloroflexi,34DFR@301297|Dehalococcoidia 301297|Dehalococcoidia C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4 k59_1160671_1 485916.Dtox_2351 4.84e-38 139.0 COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia,261I3@186807|Peptococcaceae 186801|Clostridia C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) pyrK - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_1523107_2 518766.Rmar_0879 5.3e-10 64.3 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1FISS@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1632079_1 1177928.TH2_04368 3.91e-52 170.0 COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2U6ZN@28211|Alphaproteobacteria,2JSEH@204441|Rhodospirillales 204441|Rhodospirillales O Redoxin - - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - Redoxin k59_642672_1 443143.GM18_3067 1.3e-20 90.5 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,42MG0@68525|delta/epsilon subdivisions,2WJE1@28221|Deltaproteobacteria,43TYY@69541|Desulfuromonadales 28221|Deltaproteobacteria J PFAM tRNA synthetase, class II (G, H, P and S) hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_221467_1 1046724.KB889874_gene2131 2.15e-73 241.0 COG4176@1|root,COG4176@2|Bacteria,1MUM4@1224|Proteobacteria 1224|Proteobacteria P ABC-type proline glycine betaine transport system permease component opuAB - - ko:K02001 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1 k59_1578936_1 470.IX87_16320 1.88e-39 139.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,3NJ9G@468|Moraxellaceae 1236|Gammaproteobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355 Ubie_methyltran k59_221469_1 247634.GPB2148_3142 1.74e-106 333.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,1RZZE@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the GcvT family - - - - - - - - - - - - DAO,FAO_M,GCV_T,GCV_T_C k59_693284_2 498761.HM1_3125 1.91e-09 59.3 2DSV3@1|root,33HII@2|Bacteria,1VQ64@1239|Firmicutes,24VWA@186801|Clostridia 186801|Clostridia S ORF located using Blastx - - - - - - - - - - - - - k59_799627_1 2340.JV46_06350 4.75e-101 308.0 COG2143@1|root,COG2143@2|Bacteria,1QDKY@1224|Proteobacteria,1RZ7R@1236|Gammaproteobacteria,1JA4U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Thioredoxin-like domain - - - - - - - - - - - - Thioredoxin_2 k59_1216311_1 323097.Nham_0984 3.47e-21 92.4 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2U3RT@28211|Alphaproteobacteria,3JX2R@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E 3-dehydroquinate synthase - - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_1216311_2 861299.J421_5635 5.93e-94 288.0 COG1082@1|root,COG1082@2|Bacteria 2|Bacteria G myo-inosose-2 dehydratase activity - - - - - - - - - - - - AP_endonuc_2 k59_1269375_1 444860.E3SIZ0_9CAUD 6.4e-107 330.0 4QF7I@10239|Viruses,4QYCA@35237|dsDNA viruses no RNA stage,4QT9A@28883|Caudovirales,4QKJH@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_273688_1 1380394.JADL01000010_gene4119 0.000959 44.3 COG3193@1|root,COG3193@2|Bacteria,1RGUD@1224|Proteobacteria,2UGI0@28211|Alphaproteobacteria,2JZSK@204441|Rhodospirillales 204441|Rhodospirillales S Haem-degrading - - - - - - - - - - - - Haem_degrading k59_273688_2 1123321.KB905823_gene4610 0.000455 42.7 COG0665@1|root,COG0665@2|Bacteria,2I9UF@201174|Actinobacteria 201174|Actinobacteria E PFAM FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_430234_2 390235.PputW619_1239 2.27e-12 68.6 COG0406@1|root,COG0406@2|Bacteria,1RHAT@1224|Proteobacteria,1S69R@1236|Gammaproteobacteria,1YY5H@136845|Pseudomonas putida group 1236|Gammaproteobacteria G alpha-ribazole phosphatase cobC - 3.1.3.73,5.4.2.12 ko:K02226,ko:K15634 ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00122 R01518,R04594,R11173 RC00017,RC00536 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_1478295_2 1122134.KB893650_gene760 1.42e-16 79.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1XJA6@135619|Oceanospirillales 135619|Oceanospirillales O Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host djlA - - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_952732_1 1028307.EAE_02565 3.5e-07 51.6 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,3X1HI@547|Enterobacter 1236|Gammaproteobacteria J histidyl-tRNA synthetase - - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_His k59_1110154_1 96561.Dole_2306 7.14e-33 123.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,42P8R@68525|delta/epsilon subdivisions,2WKIR@28221|Deltaproteobacteria,2MIUI@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the RNA methyltransferase TrmD family trmD GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - Methyltrn_RNA_4,tRNA_m1G_MT k59_1110154_2 933262.AXAM01000016_gene159 2.78e-10 60.8 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,42TGI@68525|delta/epsilon subdivisions,2WQJU@28221|Deltaproteobacteria,2MKM1@213118|Desulfobacterales 28221|Deltaproteobacteria J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_1371086_1 1232410.KI421421_gene3777 2.69e-32 126.0 COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria,43SZU@69541|Desulfuromonadales 28221|Deltaproteobacteria GM Protein of unknown function (DUF2867) - - - - - - - - - - - - DUF2867,NAD_binding_10 k59_1478301_1 1242864.D187_007864 1.13e-25 109.0 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria 1224|Proteobacteria C cytochrome p450 - - - ko:K15468 - - - - ko00000,ko01008 - - - p450 k59_167665_1 304371.MCP_1242 1.26e-10 66.2 COG1131@1|root,arCOG00194@2157|Archaea,2XTCU@28890|Euryarchaeota 28890|Euryarchaeota E ABC-type multidrug transport system ATPase component - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1632645_1 1123501.KB902295_gene3550 4.83e-29 119.0 COG0845@1|root,COG2203@1|root,COG0845@2|Bacteria,COG2203@2|Bacteria,1N97Q@1224|Proteobacteria,2U22Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria M GAF domain protein - - - - - - - - - - - - Biotin_lipoyl_2,GAF,HlyD_3,HlyD_D23 k59_643616_2 292415.Tbd_2582 1.45e-73 230.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2VHG9@28216|Betaproteobacteria,1KSA3@119069|Hydrogenophilales 119069|Hydrogenophilales F Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_1161150_1 1379270.AUXF01000001_gene2084 1.18e-46 166.0 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 k59_1005093_1 1122951.ATUE01000007_gene779 1.14e-12 67.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,3NJ97@468|Moraxellaceae 1236|Gammaproteobacteria E Aminotransferase class I and II dapC - 2.6.1.17 ko:K14261,ko:K14267 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1005093_2 292415.Tbd_1222 1.76e-36 134.0 COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,2VQEZ@28216|Betaproteobacteria 28216|Betaproteobacteria EG of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_484763_1 105559.Nwat_2718 6.75e-33 123.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,1RNMF@1236|Gammaproteobacteria,1WVZX@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_1371104_1 1207063.P24_03830 1.22e-26 108.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria,2JP8A@204441|Rhodospirillales 204441|Rhodospirillales C FAD linked oxidases, C-terminal domain - - - ko:K18930 - - - - ko00000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_379305_1 1121949.AQXT01000002_gene3018 5.24e-49 174.0 COG0318@1|root,COG0318@2|Bacteria,1MVJ1@1224|Proteobacteria,2TUQ9@28211|Alphaproteobacteria,43ZAH@69657|Hyphomonadaceae 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.42 ko:K00666,ko:K18688 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_117102_1 313628.LNTAR_25215 8.44e-17 79.7 COG3119@1|root,COG3119@2|Bacteria 2|Bacteria P arylsulfatase activity - - - - - - - - - - - - Sulfatase k59_117102_2 616991.JPOO01000003_gene1604 1.1e-30 120.0 COG3119@1|root,COG3119@2|Bacteria,4NEM3@976|Bacteroidetes,1HZWB@117743|Flavobacteriia,23G8D@178469|Arenibacter 976|Bacteroidetes P Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Sulfatase k59_117103_1 160488.PP_3784 8.66e-08 61.2 COG0251@1|root,COG0251@2|Bacteria,1NQGP@1224|Proteobacteria,1S4VD@1236|Gammaproteobacteria 1236|Gammaproteobacteria J pteridine-dependent deoxygenase - - - - - - - - - - - - - k59_1424811_1 768671.ThimaDRAFT_3446 8.52e-73 236.0 COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria,1WWH7@135613|Chromatiales 135613|Chromatiales HJ ATP-grasp - - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - Acetyltransf_1,RimK k59_901207_1 756499.Desde_2657 1.8e-25 98.2 COG4627@1|root,COG4627@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Dabb k59_1478353_1 1229909.NSED_07400 7.85e-87 262.0 COG1226@1|root,arCOG01964@2157|Archaea 2157|Archaea P PFAM Ion transport - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944 - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans,Ion_trans_2 k59_167687_1 768671.ThimaDRAFT_4300 5.05e-66 205.0 COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,1RNUG@1236|Gammaproteobacteria,1WY4E@135613|Chromatiales 135613|Chromatiales C PFAM NADH Ubiquinone - - - - - - - - - - - - Oxidored_q6 k59_167687_2 243233.MCA1138 2.28e-40 145.0 COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,1QUBF@1224|Proteobacteria,1RSJ4@1236|Gammaproteobacteria,1XERA@135618|Methylococcales 135618|Methylococcales C Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - - - - - - - - - - Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases k59_222073_1 1177154.Y5S_02392 2.17e-80 259.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1RMHR@1236|Gammaproteobacteria,1XHP9@135619|Oceanospirillales 135619|Oceanospirillales Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_587547_1 338966.Ppro_2475 8.36e-09 59.3 COG1596@1|root,COG1596@2|Bacteria,1RD6G@1224|Proteobacteria,4347P@68525|delta/epsilon subdivisions,2X20G@28221|Deltaproteobacteria,43TQ9@69541|Desulfuromonadales 28221|Deltaproteobacteria M Polysaccharide biosynthesis/export protein - - - - - - - - - - - - Poly_export,SLBB k59_117118_1 953739.SVEN_0524 1.98e-66 214.0 COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria 201174|Actinobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins lipP - - - - - - - - - - - Beta-lactamase k59_1270381_1 393921.HQ45_00785 1.06e-13 72.4 COG1092@1|root,COG1092@2|Bacteria,4NG9S@976|Bacteroidetes,2FN8H@200643|Bacteroidia,22WK0@171551|Porphyromonadaceae 976|Bacteroidetes J SAM-dependent methyltransferase rlmI - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_69019_1 83406.HDN1F_12360 1.11e-69 214.0 COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,1S2DE@1236|Gammaproteobacteria,1J63X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S UPF0114 protein yqhA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - UPF0114 k59_69019_2 187272.Mlg_1824 1.19e-09 56.2 COG3737@1|root,COG3737@2|Bacteria,1N083@1224|Proteobacteria,1SD91@1236|Gammaproteobacteria,1X23R@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF498/DUF598) - - - - - - - - - - - - DUF498 k59_6103_1 1168289.AJKI01000051_gene825 0.000117 46.2 COG2978@1|root,COG2978@2|Bacteria,4NH64@976|Bacteroidetes,2FMI9@200643|Bacteroidia,3XJ43@558415|Marinilabiliaceae 976|Bacteroidetes H AbgT putative transporter family ydaH - - ko:K12942 - - - - ko00000 - - - ABG_transport k59_6103_2 1122939.ATUD01000004_gene3878 2.22e-05 47.8 COG5652@1|root,COG5652@2|Bacteria,2HRVU@201174|Actinobacteria,4CTZB@84995|Rubrobacteria 84995|Rubrobacteria S VanZ like family - - - - - - - - - - - - VanZ k59_1161174_1 1125863.JAFN01000001_gene1710 1.02e-63 208.0 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,42PC9@68525|delta/epsilon subdivisions,2WKA4@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Na dependent nucleoside transporter - - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_1005122_1 65497.JODV01000008_gene172 2.9e-49 179.0 COG2027@1|root,COG2027@2|Bacteria,2GJPH@201174|Actinobacteria,4DY4W@85010|Pseudonocardiales 201174|Actinobacteria M D-Ala-D-Ala carboxypeptidase 3 (S13) family - - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_484804_1 1121939.L861_20350 1.54e-40 149.0 COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,1S03J@1236|Gammaproteobacteria,1XP6Z@135619|Oceanospirillales 135619|Oceanospirillales S (ABC) transporter, permease - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_1270386_1 1121106.JQKB01000013_gene5448 1.38e-17 83.2 COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria,2JQCU@204441|Rhodospirillales 204441|Rhodospirillales P Sulfatase - - - - - - - - - - - - DUF4976,Sulfatase k59_1270386_2 1234595.C725_1942 3.82e-25 103.0 COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2TR37@28211|Alphaproteobacteria,4BPPW@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the LDH2 MDH2 oxidoreductase family - - 1.5.1.21 ko:K13609 ko00310,ko00960,ko01100,map00310,map00960,map01100 - R02203 RC00135 ko00000,ko00001,ko01000 - - - Ldh_2 k59_744107_1 1123392.AQWL01000009_gene1117 1.26e-228 645.0 COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,2VHJ5@28216|Betaproteobacteria,1KS3F@119069|Hydrogenophilales 119069|Hydrogenophilales C FAD binding domain - - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2 k59_744107_2 1163617.SCD_n01726 4.93e-46 150.0 COG1146@1|root,COG1146@2|Bacteria,1RC9N@1224|Proteobacteria,2W1W6@28216|Betaproteobacteria 28216|Betaproteobacteria C Adenosine-5'-phosphosulfate reductase beta subunit - - 1.8.99.2 ko:K00395 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - APS-reductase_C,Fer4_9 k59_490812_1 1198114.AciX9_2007 1.01e-169 485.0 COG2826@1|root,COG2826@2|Bacteria,3Y896@57723|Acidobacteria,2JN59@204432|Acidobacteriia 204432|Acidobacteriia L Helix-turn-helix domain - - - - - - - - - - - - HTH_38,rve k59_649673_1 349124.Hhal_2055 5.47e-112 333.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1WW22@135613|Chromatiales 135613|Chromatiales K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_1164928_1 1283299.AUKG01000002_gene4966 1.81e-133 402.0 COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4CSGP@84995|Rubrobacteria 84995|Rubrobacteria Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_592201_1 713586.KB900536_gene823 1.74e-50 164.0 COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,1S5YQ@1236|Gammaproteobacteria,1WYJN@135613|Chromatiales 135613|Chromatiales J PFAM Class I peptide chain release factor - - - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 k59_592201_2 1049564.TevJSym_ag00280 7.88e-24 91.3 2E4UA@1|root,32ZNM@2|Bacteria,1NAZR@1224|Proteobacteria,1SC82@1236|Gammaproteobacteria,1J7E6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1484412_1 1366050.N234_20680 4.08e-56 196.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,1K0Y7@119060|Burkholderiaceae 28216|Betaproteobacteria L dna topoisomerase III topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - SWIB,Topoisom_bac,Toprim,Toprim_Crpt k59_1222119_1 713587.THITH_07285 3.83e-270 746.0 COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,1RQ65@1236|Gammaproteobacteria,1WWT1@135613|Chromatiales 135613|Chromatiales O TIGRFAM FeS assembly protein SufB - - - ko:K09014 - - - - ko00000 - - - UPF0051 k59_1222119_2 471881.PROPEN_04264 0.000579 41.2 COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,3Z25M@583|Proteus 1236|Gammaproteobacteria O ATPases associated with a variety of cellular activities sufC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 - ko:K09013 - - - - ko00000,ko02000 - - iECH74115_1262.ECH74115_2396,iECIAI1_1343.ECIAI1_1734,iECIAI39_1322.ECIAI39_1376,iECSP_1301.ECSP_2249,iECs_1301.ECs2389,iEcSMS35_1347.EcSMS35_1514,iG2583_1286.G2583_2077,iSFV_1184.SFV_1705,iSFxv_1172.SFxv_1919,iSSON_1240.SSON_1474,iS_1188.S1844,iZ_1308.Z2710 ABC_tran k59_1584454_1 1454004.AW11_01686 1.28e-29 119.0 COG1295@1|root,COG1959@1|root,COG1295@2|Bacteria,COG1959@2|Bacteria,1QICW@1224|Proteobacteria,2VPV7@28216|Betaproteobacteria 28216|Betaproteobacteria K Virulence factor BrkB - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_1115660_1 1280952.HJA_13200 3e-20 89.0 COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,2TRF6@28211|Alphaproteobacteria 28211|Alphaproteobacteria GM Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction - - 1.1.1.271 ko:K02377 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R05692 RC01014 ko00000,ko00001,ko01000 - - - Epimerase k59_1376393_1 243233.MCA1741 7.86e-76 234.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,1SKVW@1236|Gammaproteobacteria,1XDNK@135618|Methylococcales 135618|Methylococcales H Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit - - 6.2.1.9 ko:K08692 ko00630,ko00680,ko01120,ko01200,map00630,map00680,map01120,map01200 M00346 R01256 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_124301_1 518766.Rmar_1842 1.28e-61 204.0 COG2270@1|root,COG2270@2|Bacteria,4NEKI@976|Bacteroidetes,1FJQB@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S MFS/sugar transport protein - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_1431815_1 388467.A19Y_2870 4.96e-42 150.0 COG0451@1|root,COG0451@2|Bacteria,1G2RI@1117|Cyanobacteria,1H8GZ@1150|Oscillatoriales 1117|Cyanobacteria M Male sterility protein - - - - - - - - - - - - Epimerase k59_1321896_1 330214.NIDE0236 6.39e-72 218.0 COG0838@1|root,COG0838@2|Bacteria 2|Bacteria C NADH dehydrogenase (ubiquinone) activity nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_1321896_2 330214.NIDE0235 5.07e-75 226.0 COG0377@1|root,COG0377@2|Bacteria,3J11S@40117|Nitrospirae 40117|Nitrospirae C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_1223182_2 929712.KI912613_gene3094 1.67e-06 51.2 COG0003@1|root,COG0003@2|Bacteria,2GJ0J@201174|Actinobacteria 201174|Actinobacteria D Pfam Anion-transporting ATPase arsA_2 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - - - - - - - - - - ArsA_ATPase k59_1321897_1 1162668.LFE_0662 3.16e-49 169.0 COG0083@1|root,COG0083@2|Bacteria 2|Bacteria E homoserine kinase activity thrB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iECSE_1348.ECSE_0003,iJN678.thrB,iLJ478.TM0545,iSB619.SA_RS06620 GHMP_kinases_C,GHMP_kinases_N k59_854458_1 330214.NIDE1861 8.86e-25 99.4 COG5424@1|root,COG5424@2|Bacteria 2|Bacteria H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ - - 1.3.3.11 ko:K06137 - - - - ko00000,ko01000 - - - Haem_oxygenas_2 k59_854458_2 330214.NIDE1862 2.61e-48 155.0 2CC8H@1|root,330SM@2|Bacteria,3J1D6@40117|Nitrospirae 40117|Nitrospirae - - - - - - - - - - - - - - - k59_332635_1 999141.GME_03367 3.74e-38 129.0 COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,1S8W0@1236|Gammaproteobacteria,1XKET@135619|Oceanospirillales 135619|Oceanospirillales J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs hfq - - ko:K03666 ko02024,ko03018,ko05111,map02024,map03018,map05111 - - - ko00000,ko00001,ko03019,ko03036 - - - Hfq k59_332635_2 546268.NEISUBOT_04241 3.48e-13 70.1 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2VHEP@28216|Betaproteobacteria,2KPPY@206351|Neisseriales 206351|Neisseriales H Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_699529_1 1121935.AQXX01000099_gene1223 7.98e-22 91.3 COG1011@1|root,COG1011@2|Bacteria 2|Bacteria S phosphatase activity - - 3.1.3.5 ko:K07025,ko:K08723 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_699529_2 1004785.AMBLS11_13630 4.43e-12 66.6 COG0454@1|root,COG1846@1|root,COG0456@2|Bacteria,COG1846@2|Bacteria,1Q5AK@1224|Proteobacteria,1S19Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_7,MarR,MarR_2 k59_1431840_1 458817.Shal_3253 9.75e-17 78.6 COG1595@1|root,COG1595@2|Bacteria,1R7KF@1224|Proteobacteria,1S2IU@1236|Gammaproteobacteria,2QBIG@267890|Shewanellaceae 1236|Gammaproteobacteria K RNA polymerase, sigma-24 subunit, ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1321908_1 926550.CLDAP_09830 2.87e-44 161.0 COG1243@1|root,COG1243@2|Bacteria,2G5ZZ@200795|Chloroflexi 200795|Chloroflexi BK Radical_SAM C-terminal domain - - 2.3.1.48 ko:K07739 - - - - ko00000,ko01000,ko03016,ko03036 - - - Acetyltransf_1,Radical_SAM,Radical_SAM_C k59_280190_1 998088.B565_1910 1.03e-146 442.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1Y403@135624|Aeromonadales 135624|Aeromonadales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_699533_1 1121933.AUHH01000064_gene51 1.79e-84 270.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,4DPBE@85009|Propionibacteriales 201174|Actinobacteria C ferredoxin oxidoreductase korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_749622_2 391595.RLO149_c002880 1.38e-34 128.0 COG0406@1|root,COG0406@2|Bacteria,1Q2YU@1224|Proteobacteria,2VA2N@28211|Alphaproteobacteria,2P2WU@2433|Roseobacter 28211|Alphaproteobacteria G Phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 k59_749622_3 1177928.TH2_12502 7.65e-31 122.0 COG0438@1|root,COG0438@2|Bacteria,1R4Q9@1224|Proteobacteria,2TUGJ@28211|Alphaproteobacteria,2JR4M@204441|Rhodospirillales 204441|Rhodospirillales M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_1321910_1 713587.THITH_16255 6.71e-36 137.0 COG2114@1|root,COG2114@2|Bacteria,1RDES@1224|Proteobacteria,1S0RQ@1236|Gammaproteobacteria,1WX9Z@135613|Chromatiales 135613|Chromatiales T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,HAMP k59_650803_1 1100720.ALKN01000034_gene574 8.74e-179 514.0 COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2VJWJ@28216|Betaproteobacteria,4ABAY@80864|Comamonadaceae 28216|Betaproteobacteria U type II secretion system protein E cpaF1 - - ko:K02283,ko:K20527 ko02024,map02024 - - - ko00000,ko00001,ko02035,ko02044 3.A.7.4 - - T2SSE k59_491899_1 158822.LH89_16130 1.31e-23 96.3 COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,1S3NR@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_0104 CoaE k59_491899_2 349521.HCH_05280 3.35e-66 209.0 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,1RN90@1236|Gammaproteobacteria,1XIHA@135619|Oceanospirillales 135619|Oceanospirillales NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue pilD - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_593052_1 1307761.L21SP2_1468 1.22e-26 112.0 COG2211@1|root,COG2211@2|Bacteria,2J6P4@203691|Spirochaetes 203691|Spirochaetes G transporter - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_124354_1 566466.NOR53_3652 1.41e-57 190.0 COG0845@1|root,COG0845@2|Bacteria,1QWRP@1224|Proteobacteria 1224|Proteobacteria M HlyD family secretion protein - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP k59_1527442_1 444860.E3SJ54_9CAUD 4.98e-160 460.0 4QDUC@10239|Viruses,4QV7K@35237|dsDNA viruses no RNA stage,4QR22@28883|Caudovirales,4QJ6D@10662|Myoviridae 10662|Myoviridae S transferase activity - - - - - - - - - - - - - k59_807930_1 1449346.JQMO01000002_gene1606 2.6e-38 149.0 COG0480@1|root,COG0480@2|Bacteria,2HJ2Y@201174|Actinobacteria,2M0ZI@2063|Kitasatospora 201174|Actinobacteria J Elongation factor G, domain IV fusB - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_593057_1 32057.KB217480_gene8203 2.81e-70 225.0 COG0732@1|root,COG0732@2|Bacteria,1G1K5@1117|Cyanobacteria 1117|Cyanobacteria V type I restriction modification DNA specificity domain - - - - - - - - - - - - DDE_Tnp_1 k59_8378_1 580340.Tlie_0338 2.29e-65 214.0 COG0591@1|root,COG0591@2|Bacteria,3TB7Q@508458|Synergistetes 508458|Synergistetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_227439_1 1121377.KB906398_gene2171 1.99e-26 110.0 COG2124@1|root,COG2124@2|Bacteria 2|Bacteria Q cytochrome p450 cyp20 - 1.14.14.1 ko:K00493 ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120 - R03629,R04121,R05259 RC00046,RC01311 ko00000,ko00001,ko01000 - - - p450 k59_699552_1 1036674.A28LD_1196 1.13e-64 209.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,2QFQY@267893|Idiomarinaceae 1236|Gammaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine gcvT GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_2953 GCV_T,GCV_T_C k59_124365_1 1235790.C805_03145 5.54e-61 209.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,25UZB@186806|Eubacteriaceae 186801|Clostridia K Sigma-54 interaction domain - - - - - - - - - - - - PAS,PAS_4,PTS-HPr,PrpR_N,Sigma54_activat k59_1223240_1 1283300.ATXB01000002_gene2662 6.74e-09 55.8 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1XEEH@135618|Methylococcales 135618|Methylococcales F TIGRFAM glutamine synthetase, type I - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_1223240_2 398579.Spea_3928 2.09e-12 68.6 2E42P@1|root,32YZ5@2|Bacteria,1N868@1224|Proteobacteria,1SCUM@1236|Gammaproteobacteria,2QBX8@267890|Shewanellaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4124) - - - - - - - - - - - - BiPBP_C,DUF4124 k59_906902_1 465515.Mlut_04920 7.95e-16 81.6 COG1079@1|root,COG1079@2|Bacteria,2GKMB@201174|Actinobacteria,1W80R@1268|Micrococcaceae 201174|Actinobacteria S Belongs to the binding-protein-dependent transport system permease family - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_593065_1 187303.BN69_2337 1.25e-102 315.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2TSH1@28211|Alphaproteobacteria,36X2D@31993|Methylocystaceae 28211|Alphaproteobacteria C Nickel-dependent hydrogenase hupL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_1485519_1 472759.Nhal_2211 3.71e-50 171.0 COG1184@1|root,COG1184@2|Bacteria,1R0HY@1224|Proteobacteria,1T4I6@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Initiation factor 2 subunit family - - - ko:K03680 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - IF-2B k59_332670_1 937777.Deipe_2119 2.96e-17 80.9 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 k59_1321927_1 1026882.MAMP_01350 2.01e-61 211.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,4606D@72273|Thiotrichales 72273|Thiotrichales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1376450_1 1049564.TevJSym_ad00180 1.91e-19 94.0 COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1MWVZ@1224|Proteobacteria,1RQBQ@1236|Gammaproteobacteria,1J4P6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KLT COG0515 Serine threonine protein kinase stk1 - 2.7.11.1 ko:K08282,ko:K11916,ko:K12132 - - - - ko00000,ko01000,ko01001,ko02044 - - - FGE-sulfatase,Pkinase k59_1485525_1 298654.FraEuI1c_3304 9.66e-83 258.0 COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,4EUWU@85013|Frankiales 201174|Actinobacteria S PFAM Amidohydrolase 2 - - - - - - - - - - - - Amidohydro_2 k59_593070_1 379731.PST_0354 6.93e-69 233.0 COG0301@1|root,COG0607@1|root,COG0301@2|Bacteria,COG0607@2|Bacteria,1MWD3@1224|Proteobacteria,1RNZT@1236|Gammaproteobacteria,1Z04Z@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria HP Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS thiI GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07461 - ko00000,ko00001,ko01000,ko03016 - - iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307 THUMP,ThiI k59_386708_1 329726.AM1_4593 7.89e-45 147.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 k59_386708_2 1232410.KI421416_gene2677 2.06e-12 63.9 COG3012@1|root,COG3012@2|Bacteria,1MZZK@1224|Proteobacteria,42RE5@68525|delta/epsilon subdivisions,2WNNI@28221|Deltaproteobacteria,43SGT@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM SEC-C motif domain protein - - - ko:K09858 - - - - ko00000 - - - SEC-C k59_491945_1 272624.lpg1690 3.51e-83 270.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1JCZH@118969|Legionellales 118969|Legionellales C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_332693_1 696748.ASU2_01035 6.69e-43 147.0 COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,1Y71T@135625|Pasteurellales 135625|Pasteurellales L Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis rnt GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - ko:K03683 - - - - ko00000,ko01000,ko03016 - - - RNase_T k59_332693_2 1268237.G114_15461 1.41e-15 70.9 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,1Y4IQ@135624|Aeromonadales 135624|Aeromonadales C Belongs to the glutaredoxin family. Monothiol subfamily - - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin k59_124402_1 1168065.DOK_18020 1.56e-71 231.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1J4PN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009226,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0018130,GO:0019134,GO:0019438,GO:0030203,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046872,GO:0055086,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_4420,iYL1228.KPN_04135 Hexapep,Hexapep_2,NTP_transf_3 k59_1010795_1 1121035.AUCH01000022_gene3206 9.54e-65 219.0 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria,2KUH9@206389|Rhodocyclales 206389|Rhodocyclales M D-Ala-D-Ala carboxypeptidase dacB - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_540540_1 1229909.NSED_09920 1.69e-97 288.0 COG2243@1|root,arCOG00648@2157|Archaea,41SGJ@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.130,2.1.1.151 ko:K03394 ko00860,ko01100,map00860,map01100 - R03948,R05808 RC00003,RC01035,RC01662 ko00000,ko00001,ko01000 - - - TP_methylase k59_540542_2 351348.Maqu_0995 5.49e-26 105.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,465EU@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG3547 Transposase and inactivated derivatives - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_332704_1 330214.NIDE0541 1.71e-30 114.0 COG3145@1|root,COG3145@2|Bacteria 2|Bacteria L oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors - - - - - - - - - - - - 2OG-FeII_Oxy_2 k59_394658_3 1229780.BN381_210066 8.29e-17 74.7 2DS3D@1|root,33EC4@2|Bacteria,2GXNR@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_394658_4 526225.Gobs_2419 1.35e-28 104.0 2E6FA@1|root,3312Q@2|Bacteria,2GUWJ@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1650935_1 1049564.TevJSym_bo00190 3.81e-88 286.0 COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ9A@1236|Gammaproteobacteria,1J616@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NapC/NirT cytochrome c family, N-terminal region - - - ko:K02569 - - - - ko00000 - - - Cytochrom_NNT,EB_dh k59_1125143_1 105559.Nwat_2894 6.12e-65 222.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,Response_reg k59_1233958_1 349124.Hhal_2215 1.25e-13 69.7 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria,1WY2R@135613|Chromatiales 135613|Chromatiales U PFAM Biopolymer transport protein ExbD TolR - - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_1233958_2 933262.AXAM01000015_gene93 1.86e-47 162.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,2MHWF@213118|Desulfobacterales 28221|Deltaproteobacteria U PFAM MotA TolQ ExbB proton channel aglX - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_134768_1 472759.Nhal_3413 3.51e-119 346.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1S032@1236|Gammaproteobacteria,1X250@135613|Chromatiales 135613|Chromatiales S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_179830_1 68219.JNXI01000003_gene4706 2.22e-06 52.4 COG2172@1|root,COG2208@1|root,COG3829@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,COG3829@2|Bacteria,2GK8P@201174|Actinobacteria 201174|Actinobacteria T protein phosphatase 2C domain protein - - - - - - - - - - - - GAF,GAF_2,HATPase_c_2,PAS,PAS_4,PAS_8,PAS_9,SpoIIE,sCache_3_2 k59_1172949_1 383372.Rcas_1654 1.21e-28 107.0 COG2343@1|root,COG2343@2|Bacteria,2GARM@200795|Chloroflexi,3775Q@32061|Chloroflexia 32061|Chloroflexia S Domain of unknown function (DUF427) - - - - - - - - - - - - NTP_transf_9 k59_1172949_2 887898.HMPREF0551_1671 2.4e-12 70.1 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2VHJ9@28216|Betaproteobacteria,1JZYM@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM peptidase U62 modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1125163_1 1232410.KI421412_gene157 3.07e-111 338.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,42MG8@68525|delta/epsilon subdivisions,2WJWP@28221|Deltaproteobacteria,43S0X@69541|Desulfuromonadales 28221|Deltaproteobacteria L DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_1125163_2 1229205.BUPH_03618 1.04e-05 48.5 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2VHX4@28216|Betaproteobacteria,1K1XM@119060|Burkholderiaceae 28216|Betaproteobacteria H Belongs to the FPP GGPP synthase family ispB - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_1534748_1 314345.SPV1_09318 8.13e-114 339.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria 1224|Proteobacteria C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0026 Citrate_synt k59_1534748_2 1283300.ATXB01000002_gene3151 5.41e-75 235.0 COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,1S11K@1236|Gammaproteobacteria 1236|Gammaproteobacteria E 3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase aroF - 2.5.1.54,5.4.99.5 ko:K03856,ko:K04516 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022,M00024,M00025 R01715,R01826 RC00435,RC03116 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_1650960_1 1327990.S0A059_9CAUD 1.52e-100 301.0 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales,4QNC3@10744|Podoviridae 10744|Podoviridae S endonuclease activity - - - - - - - - - - - - - k59_1073146_1 224911.27355297 1.31e-50 182.0 COG0642@1|root,COG0784@1|root,COG3447@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3447@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,3JW8Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,Response_reg,dCache_1 k59_1594151_1 547045.NEISICOT_00355 1.51e-13 69.3 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,2KPTE@206351|Neisseriales 206351|Neisseriales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_1073149_1 1131553.JIBI01000031_gene2251 2.19e-34 132.0 COG1196@1|root,COG1196@2|Bacteria,1MVMQ@1224|Proteobacteria,2WC2D@28216|Betaproteobacteria,3747C@32003|Nitrosomonadales 28216|Betaproteobacteria D nuclear chromosome segregation - - - - - - - - - - - - - k59_967022_1 1415780.JPOG01000001_gene2500 2.53e-41 147.0 COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R9SN@1224|Proteobacteria,1SFN0@1236|Gammaproteobacteria,1X7VP@135614|Xanthomonadales 135614|Xanthomonadales K B12 binding domain - - - - - - - - - - - - B12-binding,B12-binding_2,MerR_1 k59_1650975_1 1280671.AUJH01000003_gene1391 1.98e-25 110.0 2CKIF@1|root,32SCE@2|Bacteria,1VRB9@1239|Firmicutes,24CQQ@186801|Clostridia,4BWDC@830|Butyrivibrio 186801|Clostridia - - - - - - - - - - - - - - Glyco_transf_11 k59_549195_1 224325.AF_2266 1.83e-12 71.2 COG0491@1|root,arCOG00498@2157|Archaea 2157|Archaea S COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B k59_1073160_1 693986.MOC_0581 2.27e-46 164.0 COG1502@1|root,COG1502@2|Bacteria,1MV8I@1224|Proteobacteria,2TTM4@28211|Alphaproteobacteria,1JT9H@119045|Methylobacteriaceae 28211|Alphaproteobacteria I PFAM phospholipase D Transphosphatidylase - - 3.1.4.4 ko:K01115 ko00564,ko00565,ko01100,ko01110,ko04014,ko04024,ko04071,ko04072,ko04144,ko04666,ko04724,ko04912,ko05231,map00564,map00565,map01100,map01110,map04014,map04024,map04071,map04072,map04144,map04666,map04724,map04912,map05231 - R01310,R02051,R07385 RC00017,RC00425 ko00000,ko00001,ko01000,ko04131 - - - PLDc,PLDc_2,SNARE_assoc k59_1497711_1 167539.Pro_1264 5.27e-52 175.0 COG1285@1|root,COG1285@2|Bacteria 2|Bacteria E pathogenesis - - - - - - - - - - - - DUF4956 k59_1497711_2 1131269.AQVV01000013_gene1742 9.02e-32 129.0 28JA7@1|root,2Z951@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - CotH k59_504288_1 983545.Glaag_2804 8.8e-05 45.8 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1RMD0@1236|Gammaproteobacteria,466V5@72275|Alteromonadaceae 1236|Gammaproteobacteria K Transcriptional regulatory protein, C terminal baeR - - ko:K07664,ko:K18144 ko01501,ko02020,map01501,map02020 M00450,M00645,M00646,M00648,M00649,M00655 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_663241_1 1167006.UWK_03295 5.3e-10 61.2 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2MHNT@213118|Desulfobacterales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K01338,ko:K04076,ko:K04770 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Lon_C k59_1594166_1 999611.KI421504_gene1465 1.59e-63 216.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2TRXN@28211|Alphaproteobacteria,280YJ@191028|Leisingera 28211|Alphaproteobacteria M Penicillin-binding Protein dimerisation domain mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_1384710_1 1229909.NSED_00850 9.21e-60 192.0 arCOG08023@1|root,arCOG08023@2157|Archaea,41SKK@651137|Thaumarchaeota 651137|Thaumarchaeota S Zinc finger domain - - - - - - - - - - - - zinc_ribbon_2 k59_1384710_2 436308.Nmar_0210 2.71e-36 124.0 COG0526@1|root,arCOG01972@2157|Archaea,41SSR@651137|Thaumarchaeota 651137|Thaumarchaeota O Thioredoxin - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_88115_1 1394178.AWOO02000030_gene4759 2.28e-08 58.9 COG2197@1|root,COG2197@2|Bacteria,2GJ5I@201174|Actinobacteria,4EPKH@85012|Streptosporangiales 201174|Actinobacteria T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_289753_1 713586.KB900536_gene2412 1.26e-63 207.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1WWTF@135613|Chromatiales 135613|Chromatiales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane - - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_1290251_2 945713.IALB_0020 2.01e-49 161.0 COG4747@1|root,COG4747@2|Bacteria 2|Bacteria - - hom - 1.1.1.3,1.1.1.399,1.1.1.95,1.3.1.12,4.3.1.19 ko:K00003,ko:K00058,ko:K01754,ko:K04517,ko:K04767 ko00260,ko00270,ko00290,ko00300,ko00400,ko00401,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00400,map00401,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00017,M00018,M00020,M00025,M00570 R00220,R00996,R01513,R01728,R01773,R01775 RC00031,RC00087,RC00125,RC00418,RC02600 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3 k59_820322_1 1121441.AUCX01000002_gene2758 2.05e-51 182.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,42NFP@68525|delta/epsilon subdivisions,2WK64@28221|Deltaproteobacteria,2M9T7@213115|Desulfovibrionales 28221|Deltaproteobacteria EQ PFAM Hydantoinase oxoprolinase hyuA - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_1534786_1 118168.MC7420_5195 5.31e-07 55.8 COG1426@1|root,COG1426@2|Bacteria,1G5I6@1117|Cyanobacteria,1HBBI@1150|Oscillatoriales 1117|Cyanobacteria S COGs COG1426 conserved - - - - - - - - - - - - DUF4115,HTH_25 k59_179877_1 224719.Abm4_1083 0.000122 50.4 COG2244@1|root,arCOG02209@2157|Archaea,2XSUR@28890|Euryarchaeota,23PBE@183925|Methanobacteria 183925|Methanobacteria S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_C k59_1594182_1 1397666.RS24_00104 2.26e-55 194.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1534792_2 479434.Sthe_0800 1.67e-13 75.5 COG0520@1|root,COG0520@2|Bacteria,2G5T3@200795|Chloroflexi,27XIH@189775|Thermomicrobia 189775|Thermomicrobia E Beta-eliminating lyase - - - - - - - - - - - - Aminotran_5 k59_1290266_2 1229909.NSED_07615 5.36e-22 87.8 arCOG08701@1|root,arCOG08701@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1594187_1 1178482.BJB45_00620 3.84e-23 99.4 COG1028@1|root,COG1028@2|Bacteria,1MU73@1224|Proteobacteria,1RR5Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1125254_1 383372.Rcas_1497 9.94e-61 205.0 COG0405@1|root,COG0405@2|Bacteria,2G5R2@200795|Chloroflexi,374X4@32061|Chloroflexia 32061|Chloroflexia E PFAM gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_341974_2 1148.1652697 1.97e-15 80.9 COG0661@1|root,COG0661@2|Bacteria,1G11X@1117|Cyanobacteria,1H4MT@1142|Synechocystis 1117|Cyanobacteria S ABC1 family - - - - - - - - - - - - ABC1 k59_1329345_1 1442598.JABW01000004_gene151 8.82e-28 119.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions 1224|Proteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_758512_2 396588.Tgr7_0462 2.56e-50 167.0 COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,1S3GT@1236|Gammaproteobacteria,1X151@135613|Chromatiales 135613|Chromatiales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1073238_1 330214.NIDE1184 8.77e-101 301.0 COG2159@1|root,COG2159@2|Bacteria 2|Bacteria E amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1290302_1 1279009.ADICEAN_02128 3.91e-44 153.0 COG1357@1|root,COG1357@2|Bacteria,4NY1Q@976|Bacteroidetes,47WKP@768503|Cytophagia 976|Bacteroidetes S Pentapeptide repeats (9 copies) - - - - - - - - - - - - Pentapeptide k59_236302_1 479434.Sthe_3485 5.62e-134 395.0 COG1239@1|root,COG1239@2|Bacteria,2GB7G@200795|Chloroflexi,27XRK@189775|Thermomicrobia 189775|Thermomicrobia H Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX - - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - - - k59_1594217_1 1469245.JFBG01000006_gene1597 7.71e-124 364.0 COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,1RRHH@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Sarcosine oxidase, subunit beta soxB - 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO k59_1651073_1 765911.Thivi_3466 7.83e-64 211.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1WWMF@135613|Chromatiales 135613|Chromatiales O PFAM Magnesium chelatase, ChlI subunit - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_1073257_1 1125863.JAFN01000001_gene1438 4.63e-150 461.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_863569_1 330214.NIDE2054 1.13e-109 325.0 COG1186@1|root,COG1186@2|Bacteria,3J0EX@40117|Nitrospirae 40117|Nitrospirae J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_758525_1 436308.Nmar_0258 1.91e-117 351.0 COG1053@1|root,arCOG00571@2157|Archaea,41SAM@651137|Thaumarchaeota 651137|Thaumarchaeota C fumarate reductase flavoprotein - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_394770_1 1217720.ALOX01000004_gene4114 1.76e-25 106.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TQMV@28211|Alphaproteobacteria,2JQVE@204441|Rhodospirillales 204441|Rhodospirillales G Glucose dehydrogenase - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - PQQ k59_394770_2 926550.CLDAP_08960 1.81e-68 225.0 COG0490@1|root,COG0569@1|root,COG1226@1|root,COG0490@2|Bacteria,COG0569@2|Bacteria,COG1226@2|Bacteria 2|Bacteria P (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - - - - - - - - - - Ion_trans_2,TrkA_C,TrkA_N k59_342017_1 1278309.KB907100_gene1903 1.15e-101 316.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1XI04@135619|Oceanospirillales 135619|Oceanospirillales L exonuclease recJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_1651088_1 498761.HM1_0436 1.36e-23 98.2 COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia 186801|Clostridia S PHP domain - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_550396_1 1229909.NSED_03370 4.28e-33 124.0 COG1262@1|root,arCOG03517@2157|Archaea,41T1B@651137|Thaumarchaeota 651137|Thaumarchaeota S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase k59_550396_2 436308.Nmar_0653 1.51e-47 162.0 COG4301@1|root,arCOG06722@2157|Archaea,41SWR@651137|Thaumarchaeota 651137|Thaumarchaeota S Histidine-specific methyltransferase, SAM-dependent - - - - - - - - - - - - Methyltransf_33 k59_1330394_1 765913.ThidrDRAFT_2128 5.29e-48 166.0 COG1808@1|root,COG1808@2|Bacteria,1NMS3@1224|Proteobacteria,1RRTC@1236|Gammaproteobacteria,1WWHR@135613|Chromatiales 135613|Chromatiales I Domain of unknown function (DUF389) - - - - - - - - - - - - DUF389 k59_1330394_2 913325.N799_11545 8.86e-07 51.2 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1X3E2@135614|Xanthomonadales 135614|Xanthomonadales S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_968178_1 1379281.AVAG01000010_gene1338 8.1e-28 111.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2M91M@213115|Desulfovibrionales 28221|Deltaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1276 CTP_synth_N,GATase k59_1126944_1 395493.BegalDRAFT_0113 3.55e-67 209.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,460M5@72273|Thiotrichales 72273|Thiotrichales S Bacterial transferase hexapeptide - - - - - - - - - - - - Hexapep k59_1291875_1 1232683.ADIMK_0257 5.95e-37 145.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,465N7@72275|Alteromonadaceae 1236|Gammaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1291875_2 986075.CathTA2_2210 1.78e-221 636.0 COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,4HAG1@91061|Bacilli 91061|Bacilli J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_1074806_1 4513.MLOC_62884.1 1.38e-71 230.0 COG0183@1|root,KOG1390@2759|Eukaryota,37IMT@33090|Viridiplantae,3G8HX@35493|Streptophyta,3KQ17@4447|Liliopsida,3I4E6@38820|Poales 35493|Streptophyta I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1652623_1 436308.Nmar_0240 2.7e-19 84.7 COG0470@1|root,arCOG00469@2157|Archaea,41SFJ@651137|Thaumarchaeota 651137|Thaumarchaeota L Replication factor C - - - ko:K04801 ko03030,map03030 - - - ko00000,ko00001,ko03032 - - - DNA_pol3_delta2,Rep_fac_C,RuvB_N k59_1652623_2 436308.Nmar_0241 3.78e-63 196.0 arCOG00552@1|root,arCOG00552@2157|Archaea,41SRW@651137|Thaumarchaeota 651137|Thaumarchaeota L GINS complex protein - - - ko:K09723 - - - - ko00000,ko03032 - - - Sld5 k59_1595294_1 671143.DAMO_1537 3.3e-71 229.0 COG1653@1|root,COG1653@2|Bacteria,2NP9E@2323|unclassified Bacteria 2|Bacteria G Bacterial extracellular solute-binding protein thuE - - ko:K02027,ko:K10236 ko02010,map02010 M00204,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.17 - - SBP_bac_1,SBP_bac_8 k59_1291882_1 383372.Rcas_3083 7.41e-154 447.0 COG0677@1|root,COG0677@2|Bacteria,2G5PP@200795|Chloroflexi,3756K@32061|Chloroflexia 32061|Chloroflexia M PFAM UDP-glucose GDP-mannose dehydrogenase - - 1.1.1.136 ko:K13015 ko00520,map00520 - R00421 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_395838_1 864069.MicloDRAFT_00027210 6.96e-32 116.0 COG3415@1|root,COG3415@2|Bacteria,1ND8F@1224|Proteobacteria,2UEU9@28211|Alphaproteobacteria,1JZAJ@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - HTH_28,HTH_Tnp_IS630 k59_237475_1 1041139.KB902683_gene2761 3.24e-54 186.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_505978_1 46429.BV95_02512 1.38e-140 408.0 COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria,2K3QS@204457|Sphingomonadales 204457|Sphingomonadales C Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_918284_1 349124.Hhal_2416 3.11e-29 117.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales 135613|Chromatiales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_918284_2 713586.KB900536_gene2406 1.61e-20 90.1 COG3087@1|root,COG3087@2|Bacteria,1RCC0@1224|Proteobacteria,1SBGX@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Sporulation related domain - - - - - - - - - - - - SPOR k59_89911_1 1419583.V466_05665 5.5e-51 182.0 COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1YPAW@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase ykoW - - - - - - - - - - - 4HB_MCP_1,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_968198_1 1144275.COCOR_06474 3.28e-52 174.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,42N84@68525|delta/epsilon subdivisions,2WJKT@28221|Deltaproteobacteria,2Z0A2@29|Myxococcales 28221|Deltaproteobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_968198_2 742823.HMPREF9465_01341 8.5e-23 90.5 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,4PR63@995019|Sutterellaceae 28216|Betaproteobacteria K Nitrogen regulatory protein P-II glnB - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_821960_1 1238182.C882_2413 9.93e-143 412.0 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2TR10@28211|Alphaproteobacteria,2JPTQ@204441|Rhodospirillales 204441|Rhodospirillales C electron transfer flavoprotein, alpha subunit etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_1133912_1 632335.Calkr_2084 0.000345 49.3 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,42FJ3@68295|Thermoanaerobacterales 186801|Clostridia L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_1026353_1 713586.KB900536_gene37 3.74e-71 244.0 COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria 1224|Proteobacteria L double-strand break repair protein AddB addB - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1 k59_1335570_1 1286106.MPL1_02188 1.38e-51 184.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,46034@72273|Thiotrichales 72273|Thiotrichales U TIGRFAM type IV pilus secretin (or competence protein) PilQ pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_142954_1 330214.NIDE1012 6.04e-06 47.0 COG1714@1|root,COG1714@2|Bacteria,3J0U3@40117|Nitrospirae 40117|Nitrospirae S RDD family - - - - - - - - - - - - RDD k59_142954_2 330214.NIDE1011 6.65e-50 165.0 COG0760@1|root,COG0760@2|Bacteria,3J1BR@40117|Nitrospirae 40117|Nitrospirae O SurA N-terminal domain - - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - SurA_N_3 k59_96945_1 396588.Tgr7_3259 3.06e-38 139.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1WVZ2@135613|Chromatiales 135613|Chromatiales E TIGRFAM glutamine synthetase, type I glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_1081916_1 1487921.DP68_07705 4.07e-07 55.8 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1TQX3@1239|Firmicutes,24A3W@186801|Clostridia,36FUZ@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_514117_1 349124.Hhal_2078 1.36e-37 135.0 COG1586@1|root,COG1586@2|Bacteria,1MXPT@1224|Proteobacteria,1RQSX@1236|Gammaproteobacteria,1WX2Z@135613|Chromatiales 135613|Chromatiales E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speD - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc k59_514117_2 344747.PM8797T_03995 6.6e-62 206.0 COG0008@1|root,COG0008@2|Bacteria,2IYSE@203682|Planctomycetes 203682|Planctomycetes J tRNA synthetases class I (E and Q), anti-codon binding domain glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_1660824_1 580340.Tlie_1859 1.44e-17 82.4 COG0281@1|root,COG0281@2|Bacteria,3T9QC@508458|Synergistetes 508458|Synergistetes C Malic enzyme, NAD binding domain - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic k59_1660824_2 1229909.NSED_05330 6.2e-67 215.0 COG1378@1|root,arCOG02037@2157|Archaea,41T5N@651137|Thaumarchaeota 651137|Thaumarchaeota K transcriptional - - - - - - - - - - - - TrmB k59_1391026_1 330214.NIDE0810 2.45e-38 135.0 COG0190@1|root,COG0190@2|Bacteria,3J0FT@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_1179379_1 1211114.ALIP01000118_gene2093 2.93e-150 445.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1X3IX@135614|Xanthomonadales 135614|Xanthomonadales C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_350425_1 1283300.ATXB01000001_gene1279 3.3e-24 95.1 2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SHAU@1236|Gammaproteobacteria,1XFBV@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - k59_243392_1 555778.Hneap_0052 9.28e-98 303.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1WWGN@135613|Chromatiales 135613|Chromatiales F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_673001_1 305700.B447_19034 5.18e-83 249.0 COG1795@1|root,COG1795@2|Bacteria,1NDRY@1224|Proteobacteria,2VJ22@28216|Betaproteobacteria,2KVWS@206389|Rhodocyclales 206389|Rhodocyclales S Formaldehyde-activating enzyme (Fae) - - 4.2.1.147 ko:K10713 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R08058 RC01583,RC01795 ko00000,ko00001,ko01000 - - - Fae k59_673001_2 1287116.X734_10565 1.35e-06 51.6 COG1767@1|root,COG1767@2|Bacteria,1RAWI@1224|Proteobacteria,2U5HF@28211|Alphaproteobacteria,43N73@69277|Phyllobacteriaceae 28211|Alphaproteobacteria H ATP:dephospho-CoA triphosphoribosyl transferase - - 2.4.2.52 ko:K05966 ko02020,map02020 - R09675 RC00049,RC00063 ko00000,ko00001,ko01000 - - - CitG k59_608014_1 1121861.KB899911_gene1367 1.09e-17 87.0 COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2TSE9@28211|Alphaproteobacteria,2JST0@204441|Rhodospirillales 204441|Rhodospirillales EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_673007_1 1121015.N789_13680 2.6e-74 247.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X3JU@135614|Xanthomonadales 135614|Xanthomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_514155_1 697282.Mettu_2365 3.58e-60 205.0 COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,1RSJC@1236|Gammaproteobacteria,1XEMK@135618|Methylococcales 135618|Methylococcales S Dynamin family - - - - - - - - - - - - Dynamin_N k59_96984_1 1000569.HMPREF1040_1606 1.96e-13 77.4 COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,4H27E@909932|Negativicutes 909932|Negativicutes L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_1507581_1 1335757.SPICUR_01535 1.43e-28 106.0 COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1WYPW@135613|Chromatiales 135613|Chromatiales K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_715509_1 1232410.KI421426_gene1468 3e-16 77.0 2ERVI@1|root,33JEQ@2|Bacteria,1NMQ8@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1449613_1 1303518.CCALI_00872 4.62e-13 72.0 COG1600@1|root,COG1600@2|Bacteria 2|Bacteria C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) - - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_1449613_2 1118058.CAGY01000001_gene297 6.91e-05 44.3 COG0584@1|root,COG0584@2|Bacteria,2GJ5W@201174|Actinobacteria,4D464@85005|Actinomycetales 201174|Actinobacteria C Glycerophosphodiester phosphodiesterase family protein glpQ2 - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_1081967_1 656519.Halsa_0054 2.11e-67 215.0 COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,249HN@186801|Clostridia,3WA8E@53433|Halanaerobiales 186801|Clostridia L Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_515789_1 582744.Msip34_1854 1.72e-28 119.0 COG2202@1|root,COG3447@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3447@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KKZP@206350|Nitrosomonadales 206350|Nitrosomonadales T PFAM EAL domain protein - - - - - - - - - - - - CHASE,EAL,GAF_2,GGDEF,MASE1,PAS_3,PAS_9 k59_402038_2 1214101.BN159_0306 2e-06 50.1 COG3409@1|root,COG3409@2|Bacteria 2|Bacteria M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - PG_binding_1 k59_1243275_1 1449976.KALB_7718 1.67e-12 73.9 COG2141@1|root,COG2141@2|Bacteria,2GM7W@201174|Actinobacteria,4E0XA@85010|Pseudonocardiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1509260_1 357804.Ping_3368 3.03e-32 124.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,2QH44@267894|Psychromonadaceae 1236|Gammaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_871239_1 1411123.JQNH01000001_gene2388 4.9e-86 263.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2TQSZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the arginase family speB - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_515803_1 1408419.JHYG01000005_gene560 4.41e-58 192.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria,2JPB2@204441|Rhodospirillales 204441|Rhodospirillales Q COG0767 ABC-type transport system involved in resistance to organic solvents, permease component - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_515803_2 158822.LH89_00390 2.42e-08 54.7 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,1RSHE@1236|Gammaproteobacteria 1236|Gammaproteobacteria E (ABC) transporter - - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran k59_716691_1 338966.Ppro_3326 5.89e-11 64.3 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,43UJY@69541|Desulfuromonadales 28221|Deltaproteobacteria U PFAM MotA TolQ ExbB proton channel aglX - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_402054_1 930171.Asphe3_02420 7.52e-11 64.3 COG0584@1|root,COG0584@2|Bacteria,2GJ5W@201174|Actinobacteria,1W944@1268|Micrococcaceae 201174|Actinobacteria C Glycerophosphoryl diester phosphodiesterase family glpQ2 - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_402054_2 1200557.JHWV01000008_gene2106 1.88e-32 119.0 COG1522@1|root,COG1522@2|Bacteria,1V88V@1239|Firmicutes,4H5J8@909932|Negativicutes 909932|Negativicutes K helix_turn_helix ASNC type - - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24 k59_515815_1 243231.GSU2845 1.36e-64 201.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,42QS6@68525|delta/epsilon subdivisions,2WMPD@28221|Deltaproteobacteria,43U9H@69541|Desulfuromonadales 28221|Deltaproteobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_515815_2 1123518.ARWI01000001_gene1024 2.11e-19 83.2 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,460S8@72273|Thiotrichales 72273|Thiotrichales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_557584_1 396588.Tgr7_2292 2.66e-61 202.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1WWN1@135613|Chromatiales 135613|Chromatiales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_716709_1 292459.STH2557 3.81e-42 149.0 COG0498@1|root,COG0498@2|Bacteria,1TP25@1239|Firmicutes,25B08@186801|Clostridia 186801|Clostridia E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_716709_2 909663.KI867150_gene729 1.7e-13 70.5 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,42MGS@68525|delta/epsilon subdivisions,2WJ1K@28221|Deltaproteobacteria,2MQ61@213462|Syntrophobacterales 28221|Deltaproteobacteria E PFAM Homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_1450582_1 946362.XP_004994845.1 2.51e-10 60.5 COG0071@1|root,KOG0710@2759|Eukaryota,3A9Y1@33154|Opisthokonta 33154|Opisthokonta O cellular response to heat - GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0006457,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0010494,GO:0032991,GO:0033554,GO:0034605,GO:0034620,GO:0035770,GO:0035966,GO:0035967,GO:0036464,GO:0042221,GO:0042802,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051082,GO:0051716,GO:0051788,GO:0061077,GO:0070887,GO:0071218,GO:0071310,GO:0097159,GO:1901363,GO:1990904 - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_557599_1 768671.ThimaDRAFT_0041 1.16e-115 347.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1WXM2@135613|Chromatiales 135613|Chromatiales C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_716720_1 1122138.AQUZ01000004_gene891 1.82e-16 76.6 COG3080@1|root,COG3080@2|Bacteria,2IMEN@201174|Actinobacteria 201174|Actinobacteria C Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane frdD - - ko:K00247 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - iNJ661.Rv1555 Fumarate_red_D k59_716720_2 1279038.KB907337_gene209 2.59e-18 82.0 COG3029@1|root,COG3029@2|Bacteria,1RD34@1224|Proteobacteria,2UFZX@28211|Alphaproteobacteria,2JUG8@204441|Rhodospirillales 204441|Rhodospirillales C Fumarate reductase subunit C - - - - - - - - - - - - Fumarate_red_C k59_716720_3 1316936.K678_00485 7.26e-25 99.8 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2U3AH@28211|Alphaproteobacteria,2JRIM@204441|Rhodospirillales 204441|Rhodospirillales C 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - - Fer2_3,Fer4_8 k59_766194_1 1254432.SCE1572_33210 1.24e-57 202.0 COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,42Q4K@68525|delta/epsilon subdivisions,2WKQ1@28221|Deltaproteobacteria,2Z1M7@29|Myxococcales 28221|Deltaproteobacteria L DNA polymerase type-B family polB - 2.7.7.7 ko:K02336 - - - - ko00000,ko01000,ko03400 - - - DNA_pol_B,DNA_pol_B_exo1,RNase_H_2 k59_975261_1 330214.NIDE1352 1.82e-50 179.0 COG4796@1|root,COG4796@2|Bacteria,3J0Q9@40117|Nitrospirae 40117|Nitrospirae U Secretin and TonB N terminus short domain - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - Secretin,Secretin_N k59_402091_1 1313304.CALK_1537 5.82e-26 102.0 COG0467@1|root,COG0467@2|Bacteria 2|Bacteria T regulation of circadian rhythm - - - ko:K08482 - - - - ko00000 - - - ATPase k59_557611_1 436308.Nmar_0190 1.76e-44 149.0 COG0500@1|root,arCOG01773@2157|Archaea 2157|Archaea Q Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11,Methyltransf_23 k59_1450609_1 323848.Nmul_A2416 1.81e-25 106.0 COG4255@1|root,COG4255@2|Bacteria,1RA9X@1224|Proteobacteria,2WGEF@28216|Betaproteobacteria,3729Q@32003|Nitrosomonadales 28216|Betaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - PhosphMutase k59_299597_1 1229909.NSED_08185 1.2e-90 266.0 COG2947@1|root,arCOG08640@2157|Archaea,41SK6@651137|Thaumarchaeota 651137|Thaumarchaeota S EVE domain - - - - - - - - - - - - EVE k59_299597_3 1229909.NSED_08175 2.02e-14 69.7 arCOG08639@1|root,arCOG08639@2157|Archaea,41SP8@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1083192_1 404589.Anae109_3652 1.87e-11 68.9 COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,4352D@68525|delta/epsilon subdivisions,2X2SX@28221|Deltaproteobacteria,2YWNC@29|Myxococcales 28221|Deltaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - Guanylate_cyc k59_1083192_2 1121028.ARQE01000001_gene3708 0.0003 44.3 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria,2PJ7X@255475|Aurantimonadaceae 28211|Alphaproteobacteria E Pyridoxal-phosphate dependent enzyme cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_299605_1 443143.GM18_3876 2.01e-35 134.0 COG0389@1|root,COG0389@2|Bacteria,1RBTJ@1224|Proteobacteria,42QY9@68525|delta/epsilon subdivisions,2WMTI@28221|Deltaproteobacteria,43S6H@69541|Desulfuromonadales 28221|Deltaproteobacteria L impB/mucB/samB family - - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C k59_1301776_1 111780.Sta7437_2112 1.8e-36 135.0 COG1215@1|root,COG1215@2|Bacteria,1GDJY@1117|Cyanobacteria,3VJ0Y@52604|Pleurocapsales 1117|Cyanobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1301776_2 338963.Pcar_1293 9.87e-93 285.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,42KZT@68525|delta/epsilon subdivisions,2WIXY@28221|Deltaproteobacteria,43RZ8@69541|Desulfuromonadales 28221|Deltaproteobacteria F AIR synthase related protein domain protein purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1844 AIRS,AIRS_C k59_351749_1 330214.NIDE3566 8.62e-45 159.0 COG2234@1|root,COG2234@2|Bacteria,3J1BG@40117|Nitrospirae 40117|Nitrospirae S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 k59_1336668_1 287.DR97_5169 6.1e-26 106.0 COG0457@1|root,COG3271@1|root,COG0457@2|Bacteria,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,1S2EC@1236|Gammaproteobacteria,1YDEB@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Peptidase_C39 like family - - - - - - - - - - - - Peptidase_C39_2,TPR_16 k59_871309_1 118168.MC7420_2933 4.83e-13 74.7 COG0705@1|root,COG0705@2|Bacteria,1FZY1@1117|Cyanobacteria,1H9IP@1150|Oscillatoriales 1117|Cyanobacteria S (Rhomboid) family - - - - - - - - - - - - Rhomboid k59_1135220_1 187272.Mlg_0072 4.57e-90 285.0 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,1WWBM@135613|Chromatiales 135613|Chromatiales E Catalyzes the biosynthesis of agmatine from arginine speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_1135220_2 246197.MXAN_0543 3.57e-32 123.0 COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,437V8@68525|delta/epsilon subdivisions,2X34Q@28221|Deltaproteobacteria,2YU9A@29|Myxococcales 28221|Deltaproteobacteria E Peptidase dimerisation domain dapE1 - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_1301791_1 1250232.JQNJ01000001_gene1661 4.69e-71 238.0 COG1529@1|root,COG1529@2|Bacteria,4NFFU@976|Bacteroidetes,1HXJS@117743|Flavobacteriia 976|Bacteroidetes C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_1509383_2 436308.Nmar_0256 1.21e-96 287.0 COG2513@1|root,arCOG00581@2157|Archaea,41SEN@651137|Thaumarchaeota 651137|Thaumarchaeota G Phosphoenolpyruvate phosphomutase - - - - - - - - - - - - PEP_mutase k59_299626_1 395495.Lcho_3893 7.09e-38 145.0 COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,2VZQA@28216|Betaproteobacteria,1KNDH@119065|unclassified Burkholderiales 28216|Betaproteobacteria Q Multicopper oxidase - - 1.16.3.3 ko:K22349 - - - - ko00000,ko01000 - - - - k59_1243332_1 986075.CathTA2_1559 1.15e-134 404.0 COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,4HB81@91061|Bacilli 91061|Bacilli L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_457235_2 935866.JAER01000009_gene715 1.29e-14 73.6 COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4DN5N@85009|Propionibacteriales 201174|Actinobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1662676_1 472759.Nhal_2378 2.81e-135 419.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1450648_1 1144672.F966_00451 2.06e-53 182.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,3NKKZ@468|Moraxellaceae 1236|Gammaproteobacteria M Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_1509404_1 1162668.LFE_2471 2.31e-08 53.9 2ETP6@1|root,33M6W@2|Bacteria,3J18I@40117|Nitrospirae 40117|Nitrospirae - - - - - - - - - - - - - - - k59_1083239_1 205918.Psyr_3385 1.82e-18 89.0 COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1S358@1236|Gammaproteobacteria,1Z5VS@136849|Pseudomonas syringae group 1236|Gammaproteobacteria O COG4235 Cytochrome c biogenesis factor cycH - - ko:K02200 - - - - ko00000 - - - TPR_16,TPR_2 k59_351782_1 1229909.NSED_06965 1.58e-19 87.8 arCOG08777@1|root,arCOG10350@1|root,arCOG08777@2157|Archaea,arCOG10350@2157|Archaea 2157|Archaea C sister chromatid segregation - - - - - - - - - - - - - k59_354420_1 110319.CF8_3451 2.06e-27 113.0 COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4DN5T@85009|Propionibacteriales 201174|Actinobacteria E Cys/Met metabolism PLP-dependent enzyme dapC - 2.6.1.1,2.6.1.17 ko:K00812,ko:K10907,ko:K14267 ko00220,ko00250,ko00270,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230 M00016 R00355,R00694,R00734,R00896,R02433,R02619,R04475,R05052 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1452869_1 706587.Desti_2481 2.07e-153 463.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,2MQYN@213462|Syntrophobacterales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1305578_1 1096546.WYO_4381 1.81e-09 63.2 COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,2TTHW@28211|Alphaproteobacteria,1JR8Q@119045|Methylobacteriaceae 28211|Alphaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_519660_1 488538.SAR116_1713 2.4e-47 168.0 COG1304@1|root,COG1304@2|Bacteria,1QWBP@1224|Proteobacteria 1224|Proteobacteria C Protein of unknown function (DUF1116) yahG - - - - - - - - - - - DUF1116 k59_1544649_1 557599.MKAN_03230 3.16e-92 289.0 COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria,23CXI@1762|Mycobacteriaceae 201174|Actinobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3,Urease_alpha k59_1137893_1 997346.HMPREF9374_1494 1.86e-49 164.0 COG0558@1|root,COG0558@2|Bacteria,1V50T@1239|Firmicutes,4HH51@91061|Bacilli,27CU1@186824|Thermoactinomycetaceae 91061|Bacilli I CDP-alcohol phosphatidyltransferase - - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_678586_1 909663.KI867150_gene325 1.03e-28 117.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2MQVC@213462|Syntrophobacterales 28221|Deltaproteobacteria P Cation transporter/ATPase, N-terminus - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_1666411_2 465817.ETA_16710 1.31e-31 127.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,3X5S9@551|Erwinia 1236|Gammaproteobacteria L ATP-dependent hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_1085894_1 575540.Isop_0867 3.15e-12 71.2 COG2010@1|root,COG2010@2|Bacteria,2IZC1@203682|Planctomycetes 203682|Planctomycetes C cytochrome C - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_768829_1 1049564.TevJSym_ab02100 8.33e-121 360.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1J4CY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_1338901_1 857087.Metme_1631 6.55e-38 142.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1XDU0@135618|Methylococcales 135618|Methylococcales C TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 - - - ko:K03184 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R06146,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_404880_1 264402.Cagra.0909s0024.1.p 5.23e-27 108.0 COG0193@1|root,KOG2255@2759|Eukaryota,37HFV@33090|Viridiplantae,3G8N9@35493|Streptophyta,3HMCD@3699|Brassicales 35493|Streptophyta J Belongs to the PTH family - GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0016787,GO:0016788,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_404880_2 138119.DSY2267 1.57e-20 91.3 COG3004@1|root,COG3004@2|Bacteria,1TS30@1239|Firmicutes,24AB3@186801|Clostridia,261AU@186807|Peptococcaceae 186801|Clostridia P ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_678601_1 1288494.EBAPG3_28390 1.9e-36 129.0 COG0537@1|root,COG0537@2|Bacteria,1N49J@1224|Proteobacteria,2VWW7@28216|Betaproteobacteria,3737X@32003|Nitrosomonadales 28216|Betaproteobacteria FG Histidine triad (HIT) protein - - - - - - - - - - - - - k59_147673_1 396588.Tgr7_1535 5.46e-121 370.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_102308_1 338966.Ppro_2168 6.82e-82 256.0 COG3919@1|root,COG3919@2|Bacteria,1N13P@1224|Proteobacteria,42WGT@68525|delta/epsilon subdivisions,2WRKR@28221|Deltaproteobacteria,43VRY@69541|Desulfuromonadales 28221|Deltaproteobacteria S ATP-grasp domain - - - - - - - - - - - - ATP-grasp_3 k59_521395_1 1125973.JNLC01000011_gene585 0.000752 43.1 COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TT8C@28211|Alphaproteobacteria,3JXM0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_521395_2 365528.KB891148_gene4839 7.64e-62 204.0 COG2141@1|root,COG2141@2|Bacteria,2GMRE@201174|Actinobacteria,4EU7W@85013|Frankiales 201174|Actinobacteria C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Bac_luciferase k59_1087172_1 202954.BBNK01000031_gene3716 1.07e-24 100.0 COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,1RN27@1236|Gammaproteobacteria,3NIM0@468|Moraxellaceae 1236|Gammaproteobacteria S Metallo-beta-lactamase superfamily blh - - - - - - - - - - - Lactamase_B k59_1087172_2 977880.RALTA_A1774 3.89e-20 85.9 COG3728@1|root,32VVZ@2|Bacteria,1N3FD@1224|Proteobacteria,2WFU0@28216|Betaproteobacteria,1KDCG@119060|Burkholderiaceae 28216|Betaproteobacteria L Terminase - - - - - - - - - - - - DUF962 k59_355756_1 557436.Lreu_1659 2.98e-23 97.4 COG1028@1|root,COG1028@2|Bacteria,1TR1J@1239|Firmicutes,4HHQ8@91061|Bacilli,3FC9P@33958|Lactobacillaceae 91061|Bacilli IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_303732_1 713586.KB900536_gene28 5.75e-83 270.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1WXPB@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_355762_2 1306174.JODP01000013_gene7508 4.95e-37 144.0 COG0457@1|root,COG2199@1|root,COG0457@2|Bacteria,COG3706@2|Bacteria,2IA4X@201174|Actinobacteria 201174|Actinobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,TPR_12 k59_770064_1 555778.Hneap_0941 2.33e-30 124.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1WWJF@135613|Chromatiales 135613|Chromatiales M TIGRFAM RHS repeat-associated core domain - - - - - - - - - - - - RHS,RHS_repeat k59_770073_1 32049.SYNPCC7002_A1077 3.56e-37 129.0 COG0664@1|root,COG0664@2|Bacteria,1G9GW@1117|Cyanobacteria,1H4AI@1129|Synechococcus 1117|Cyanobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_770073_2 996306.SSUR61_0831 3.23e-05 46.2 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,4H9SZ@91061|Bacilli,1WT9K@1307|Streptococcus suis 91061|Bacilli E Sodium:alanine symporter family agcS - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_1546092_1 1197130.BAFM01000005_gene1174 7.37e-14 71.6 COG2159@1|root,arCOG01931@2157|Archaea,2XV9F@28890|Euryarchaeota,23SIH@183963|Halobacteria 183963|Halobacteria S metal-dependent hydrolase of the TIM-barrel fold - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_1183807_1 519989.ECTPHS_02511 3.24e-75 236.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1WWAV@135613|Chromatiales 135613|Chromatiales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_406332_1 991905.SL003B_1737 7.76e-109 323.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria,4BPN2@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_1087221_1 519989.ECTPHS_06292 1.45e-26 102.0 COG2852@1|root,COG2852@2|Bacteria,1N0QU@1224|Proteobacteria,1SAT7@1236|Gammaproteobacteria,1WZ6X@135613|Chromatiales 135613|Chromatiales V Protein of unknown function (DUF559) - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - DUF559 k59_1139175_1 591158.SSMG_02355 5.96e-48 173.0 COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria 201174|Actinobacteria I carboxylase accA2 - 6.4.1.1,6.4.1.3,6.4.1.4 ko:K01959,ko:K01965,ko:K01968 ko00020,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01120,ko01130,ko01200,ko01230,map00020,map00280,map00620,map00630,map00640,map00720,map01100,map01120,map01130,map01200,map01230 M00036,M00173,M00373,M00620,M00741 R00344,R01859,R04138 RC00040,RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv0973c Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1246998_1 1198232.CYCME_0392 6.14e-36 132.0 COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,1RNZF@1236|Gammaproteobacteria,4613M@72273|Thiotrichales 72273|Thiotrichales S Sodium Bile acid symporter family - - - ko:K03453 - - - - ko00000 2.A.28 - - SBF k59_461121_1 335543.Sfum_1366 1.05e-62 209.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42MAI@68525|delta/epsilon subdivisions,2WJ8M@28221|Deltaproteobacteria,2MQ68@213462|Syntrophobacterales 28221|Deltaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_1340084_1 1123368.AUIS01000019_gene1220 1.03e-33 119.0 COG0662@1|root,COG0662@2|Bacteria,1N7Q4@1224|Proteobacteria,1SEVR@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 k59_875287_1 1313421.JHBV01000043_gene3165 0.000945 47.4 COG1680@1|root,COG1680@2|Bacteria,4NEVS@976|Bacteroidetes,1IRZ6@117747|Sphingobacteriia 976|Bacteroidetes V COG1680 Beta-lactamase class C and other penicillin binding - - - - - - - - - - - - Beta-lactamase k59_303810_1 1260251.SPISAL_02890 1.01e-92 280.0 COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,1RNUH@1236|Gammaproteobacteria,1X2C7@135613|Chromatiales 135613|Chromatiales P binding-protein-dependent transport systems inner membrane component - - - ko:K13895 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - BPD_transp_1,OppC_N k59_1454089_1 331869.BAL199_05034 7.41e-175 499.0 COG0006@1|root,COG0006@2|Bacteria,1NTWB@1224|Proteobacteria,2TRKF@28211|Alphaproteobacteria,4BP7H@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Creatinase/Prolidase N-terminal domain pepQ - 3.4.13.9 ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_355850_1 572477.Alvin_1431 2.38e-68 216.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1WXAY@135613|Chromatiales 135613|Chromatiales EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_355850_2 631362.Thi970DRAFT_02294 3.43e-22 96.7 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,1WW5Y@135613|Chromatiales 135613|Chromatiales EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_102427_1 398525.KB900701_gene6535 2.71e-102 312.0 COG0459@1|root,COG0459@2|Bacteria,1PMNK@1224|Proteobacteria,2TTPT@28211|Alphaproteobacteria,3JXCP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_147788_1 1173023.KE650771_gene3031 9.16e-23 97.8 COG2345@1|root,COG2345@2|Bacteria,1G15S@1117|Cyanobacteria,1JIAP@1189|Stigonemataceae 1117|Cyanobacteria K DeoR-like helix-turn-helix domain sufR - - ko:K09012 - - - - ko00000,ko03000 - - - HTH_11,HTH_24,HTH_5 k59_147788_2 1121346.KB899843_gene1028 9.31e-10 62.0 COG2068@1|root,COG2068@2|Bacteria,1VA0F@1239|Firmicutes,4HDWZ@91061|Bacilli,270CM@186822|Paenibacillaceae 91061|Bacilli S MobA-like NTP transferase domain - - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_1395458_2 1487953.JMKF01000072_gene3478 1.41e-30 114.0 COG4446@1|root,COG4446@2|Bacteria,1G6W2@1117|Cyanobacteria,1HBIQ@1150|Oscillatoriales 1117|Cyanobacteria S COGs COG4446 conserved - - - - - - - - - - - - DUF1499 k59_1395458_3 1248916.ANFY01000004_gene1723 3.94e-47 159.0 COG3917@1|root,COG3917@2|Bacteria,1MV6E@1224|Proteobacteria,2TVJ4@28211|Alphaproteobacteria,2K0YH@204457|Sphingomonadales 204457|Sphingomonadales Q 2-hydroxychromene-2-carboxylate isomerase - - - - - - - - - - - - DSBA k59_355858_1 234267.Acid_3540 2.5e-30 112.0 29ITM@1|root,305QZ@2|Bacteria,3Y4F3@57723|Acidobacteria 57723|Acidobacteria - - - - - - - - - - - - - - - k59_770163_1 489825.LYNGBM3L_21220 3.79e-83 271.0 COG1216@1|root,COG5309@1|root,COG1216@2|Bacteria,COG5309@2|Bacteria,1G2MT@1117|Cyanobacteria,1H8YG@1150|Oscillatoriales 1117|Cyanobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glyco_hydro_2_C,Glycos_transf_2 k59_248701_1 395493.BegalDRAFT_1376 1.14e-37 137.0 COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,460I1@72273|Thiotrichales 72273|Thiotrichales D Part of the ABC transporter FtsEX involved in cellular division - - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_406413_2 521011.Mpal_0193 3.94e-48 165.0 COG2020@1|root,arCOG03580@2157|Archaea,2Y4MT@28890|Euryarchaeota 28890|Euryarchaeota O PFAM Isoprenylcysteine carboxyl methyltransferase - - - - - - - - - - - - ICMT k59_406413_3 32049.SYNPCC7002_A0709 2.27e-05 50.1 2CHH4@1|root,32SC0@2|Bacteria,1G6WJ@1117|Cyanobacteria,1H30A@1129|Synechococcus 1117|Cyanobacteria S Bacterial PH domain - - - - - - - - - - - - bPH_5 k59_1395473_1 436308.Nmar_0570 6.55e-103 300.0 COG2818@1|root,arCOG06523@2157|Archaea 2157|Archaea L Methyladenine glycosylase - - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_1031784_1 985054.JQEZ01000002_gene3590 2.08e-08 60.8 COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2TT0S@28211|Alphaproteobacteria,4NBDX@97050|Ruegeria 28211|Alphaproteobacteria S Alpha beta - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1139252_1 903818.KI912268_gene1284 1.52e-80 261.0 COG0441@1|root,COG0441@2|Bacteria,3Y2V0@57723|Acidobacteria 57723|Acidobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_102461_1 330214.NIDE3889 5.7e-22 94.0 COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,3J0Q6@40117|Nitrospirae 2|Bacteria C Cytochrome b/b6/petB qcrC - - ko:K00412,ko:K03888 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B,Cytochrome_CBB3 k59_102461_2 330214.NIDE3890 1.12e-62 197.0 COG0723@1|root,COG0723@2|Bacteria,3J0TT@40117|Nitrospirae 40117|Nitrospirae C Rieske [2Fe-2S] domain - - 1.10.9.1 ko:K02636,ko:K03886 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00151,M00162 R03817,R08409 RC01002 ko00000,ko00001,ko00002,ko00194,ko01000 - - - Rieske k59_147836_1 570967.JMLV01000009_gene1014 6.06e-25 103.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2JQ4Z@204441|Rhodospirillales 204441|Rhodospirillales P Belongs to the ABC transporter superfamily - - - ko:K13896 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - ABC_tran,oligo_HPY k59_410098_2 502025.Hoch_0365 2.53e-28 110.0 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,42QF3@68525|delta/epsilon subdivisions,2WKPQ@28221|Deltaproteobacteria,2Z2XW@29|Myxococcales 28221|Deltaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family gluQ - 6.1.1.17 ko:K01885,ko:K01894 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_251822_1 713586.KB900536_gene27 2.48e-113 335.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1WW7C@135613|Chromatiales 135613|Chromatiales E Belongs to the aspartokinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_1398763_1 1286632.P278_03710 1.95e-41 141.0 COG2044@1|root,COG2044@2|Bacteria,4P2I4@976|Bacteroidetes,1I8SH@117743|Flavobacteriia 976|Bacteroidetes S DsrE/DsrF-like family - - - - - - - - - - - - DrsE k59_1606591_1 1232410.KI421421_gene3825 1.1e-13 70.9 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43U53@69541|Desulfuromonadales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1606591_2 1121459.AQXE01000007_gene727 2.13e-09 60.5 COG0845@1|root,COG0845@2|Bacteria,1RI9S@1224|Proteobacteria,42PDM@68525|delta/epsilon subdivisions,2WMKT@28221|Deltaproteobacteria,2M99P@213115|Desulfovibrionales 28221|Deltaproteobacteria M Biotin-lipoyl like - - - - - - - - - - - - HlyD_D23 k59_150897_1 1437882.AZRU01000002_gene2435 1.69e-60 202.0 28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria,1YCWG@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_1607626_1 330214.NIDE3886 1.92e-39 138.0 COG3258@1|root,COG3258@2|Bacteria,3J12T@40117|Nitrospirae 40117|Nitrospirae C Cytochrome C oxidase, cbb3-type, subunit III - - 1.8.2.2 ko:K19713 - - - - ko00000,ko01000 - - - Cytochrome_CBB3 k59_1458736_1 1245471.PCA10_p1440 3.38e-125 371.0 COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,1RQA2@1236|Gammaproteobacteria,1YCTQ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - HTH_23,HTH_24,rve k59_466079_1 1163617.SCD_n00570 2.01e-21 92.4 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VI1J@28216|Betaproteobacteria 28216|Betaproteobacteria NU Type II secretion system pilC2 - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_466079_2 580332.Slit_0683 4.44e-16 80.1 2CG4C@1|root,2Z8MQ@2|Bacteria,1R6PQ@1224|Proteobacteria,2VHKG@28216|Betaproteobacteria,44WGT@713636|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1344747_1 396588.Tgr7_1528 1.52e-94 288.0 COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,1RMB8@1236|Gammaproteobacteria,1WYRX@135613|Chromatiales 135613|Chromatiales S RmuC family - - - ko:K09760 - - - - ko00000 - - - RmuC k59_20962_1 1366050.N234_31975 4.63e-59 188.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VKKS@28216|Betaproteobacteria,1K3P0@119060|Burkholderiaceae 28216|Betaproteobacteria C oxidase, subunit coxP - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_20962_2 1129794.C427_1555 1.77e-16 73.9 COG5605@1|root,COG5605@2|Bacteria,1RH8B@1224|Proteobacteria,1S95E@1236|Gammaproteobacteria 1236|Gammaproteobacteria S oxidase, subunit IV - - - - - - - - - - - - COX4_pro k59_1607636_1 1172562.HCN_1971 7.46e-09 62.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2YMQV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_774156_1 1220601.L7TJ75_9CAUD 1.1e-21 94.4 4QG7P@10239|Viruses,4QUU1@35237|dsDNA viruses no RNA stage,4QTW5@28883|Caudovirales,4QKJS@10662|Myoviridae 10662|Myoviridae S kinase activity - - - - - - - - - - - - - k59_196634_1 1038859.AXAU01000007_gene5756 2.23e-81 261.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria,3JV0V@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Amidohydrolase family MA20_22865 - - - - - - - - - - - Amidohydro_3 k59_935730_1 1461693.ATO10_10860 1.99e-103 305.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2TTQJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PFAM ATPase associated with various cellular activities, AAA_5 cbbQ - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5,CbbQ_C k59_360467_1 1150599.MPHLEI_05432 6.03e-15 75.5 COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria,235AT@1762|Mycobacteriaceae 201174|Actinobacteria C PFAM CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_360467_2 56780.SYN_02533 3.74e-07 53.9 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,42N3S@68525|delta/epsilon subdivisions,2WJ5P@28221|Deltaproteobacteria,2MQD8@213462|Syntrophobacterales 28221|Deltaproteobacteria S DNA internalization-related competence protein ComEC Rec2 - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_152687_1 38033.XP_001220221.1 4.72e-09 64.7 KOG4155@1|root,KOG4155@2759|Eukaryota 2759|Eukaryota K positive regulation of histone H3-K79 methylation SKI8 GO:0000003,GO:0000184,GO:0000228,GO:0000280,GO:0000288,GO:0000291,GO:0000346,GO:0000347,GO:0000445,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006310,GO:0006401,GO:0006402,GO:0006403,GO:0006405,GO:0006406,GO:0006611,GO:0006725,GO:0006807,GO:0006810,GO:0006886,GO:0006913,GO:0006996,GO:0007049,GO:0007127,GO:0007131,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0015031,GO:0015833,GO:0015931,GO:0016043,GO:0016070,GO:0016071,GO:0019222,GO:0019439,GO:0022402,GO:0022414,GO:0022607,GO:0031503,GO:0031974,GO:0031981,GO:0032991,GO:0033036,GO:0034427,GO:0034613,GO:0034622,GO:0034641,GO:0034655,GO:0035825,GO:0042886,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043928,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046483,GO:0046700,GO:0046907,GO:0048285,GO:0048519,GO:0050657,GO:0050658,GO:0050789,GO:0051028,GO:0051168,GO:0051169,GO:0051179,GO:0051234,GO:0051236,GO:0051321,GO:0051641,GO:0051649,GO:0055087,GO:0060255,GO:0061982,GO:0065003,GO:0065004,GO:0065007,GO:0070013,GO:0070478,GO:0070481,GO:0070727,GO:0071166,GO:0071426,GO:0071427,GO:0071702,GO:0071704,GO:0071705,GO:0071824,GO:0071840,GO:0090304,GO:0097159,GO:0140013,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1903046 - ko:K12601,ko:K12602,ko:K12880 ko03013,ko03018,ko03040,map03013,map03018,map03040 M00392,M00406 - - ko00000,ko00001,ko00002,ko03019,ko03041 - - - ANAPC4_WD40,HET,NACHT,NACHT_N,WD40 k59_308595_1 1349767.GJA_4676 2.05e-73 231.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2VIZ3@28216|Betaproteobacteria,472M8@75682|Oxalobacteraceae 28216|Betaproteobacteria H Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_935734_1 1242864.D187_003150 3.88e-80 248.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,42NC2@68525|delta/epsilon subdivisions,2WKA3@28221|Deltaproteobacteria,2YU4X@29|Myxococcales 28221|Deltaproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_253054_1 1236959.BAMT01000004_gene901 2.12e-12 67.4 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,2VRRA@28216|Betaproteobacteria,2KP9X@206350|Nitrosomonadales 206350|Nitrosomonadales S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 k59_253054_2 1283300.ATXB01000001_gene1785 6.4e-15 75.5 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,1XEHX@135618|Methylococcales 135618|Methylococcales N ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux k59_360492_1 330084.JNYZ01000029_gene16 5.03e-67 214.0 COG1878@1|root,COG1878@2|Bacteria,2GJ59@201174|Actinobacteria,4E26H@85010|Pseudonocardiales 201174|Actinobacteria S Putative cyclase - - - - - - - - - - - - Cyclase k59_982372_1 1217656.F964_04346 5.79e-45 157.0 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1RWHU@1236|Gammaproteobacteria,3NJJY@468|Moraxellaceae 1236|Gammaproteobacteria C Dehydrogenase E1 component acoA - - ko:K21416 - - - - ko00000,ko01000 - - - E1_dh k59_1145239_1 573370.DMR_23050 3.89e-29 113.0 COG0778@1|root,COG0778@2|Bacteria,1R4E3@1224|Proteobacteria,42RVJ@68525|delta/epsilon subdivisions,2WNCQ@28221|Deltaproteobacteria,2MA3B@213115|Desulfovibrionales 28221|Deltaproteobacteria C Nitroreductase family - - - - - - - - - - - - Fer4,Fer4_4,Nitroreductase k59_1458795_2 396588.Tgr7_0796 1.74e-17 84.7 COG0457@1|root,COG0457@2|Bacteria,1R50I@1224|Proteobacteria,1S4B5@1236|Gammaproteobacteria,1X26Z@135613|Chromatiales 135613|Chromatiales S Tetratricopeptide repeat - - - - - - - - - - - - - k59_774203_1 156889.Mmc1_2548 3.32e-73 231.0 COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,2U24Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Integrase - - - - - - - - - - - - HTH_32,rve,rve_3 k59_725107_1 436308.Nmar_1144 6.4e-66 211.0 COG0785@1|root,arCOG02398@2157|Archaea 2157|Archaea O cytochrome c biogenesis protein - - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD k59_196707_1 1122963.AUHB01000010_gene1538 5.6e-98 315.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,36XBQ@31993|Methylocystaceae 28211|Alphaproteobacteria EF Carbamoyl-phosphate synthetase large chain, oligomerisation domain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_196714_1 189753.AXAS01000017_gene3168 2.66e-10 59.7 COG2020@1|root,COG2020@2|Bacteria,1RBJE@1224|Proteobacteria,2U6NI@28211|Alphaproteobacteria,3JYFN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Phospholipid methyltransferase - - - - - - - - - - - - PEMT k59_196714_2 2340.JV46_12750 3.9e-57 187.0 COG0730@1|root,COG0730@2|Bacteria,1RBHH@1224|Proteobacteria,1S4D0@1236|Gammaproteobacteria,1JA0U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_196719_2 1121939.L861_18315 1.19e-07 56.2 COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria 1236|Gammaproteobacteria M ErfK YbiS YcfS YnhG family protein erfK - - ko:K16291 - - - - ko00000,ko01002,ko01011 - - - YkuD k59_1145287_1 1229517.AMFD01000008_gene460 1.26e-22 103.0 COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,4HBC7@91061|Bacilli,1YBYT@1357|Lactococcus 91061|Bacilli G Alpha mannosidase, middle domain - - 3.2.1.170,3.2.1.24 ko:K01191,ko:K15524 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C k59_1607711_1 1211579.PP4_00010 2.04e-94 292.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1YX9R@136845|Pseudomonas putida group 1236|Gammaproteobacteria F it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_1551289_1 631362.Thi970DRAFT_03780 3.63e-84 264.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales 135613|Chromatiales K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_1458845_1 246197.MXAN_4395 2.1e-17 83.6 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,42NIG@68525|delta/epsilon subdivisions,2WIR1@28221|Deltaproteobacteria,2YUKH@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_1458845_2 519989.ECTPHS_08713 1.08e-47 155.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,1WXYJ@135613|Chromatiales 135613|Chromatiales F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_982434_1 933262.AXAM01000084_gene1043 1.06e-19 93.6 COG3961@1|root,COG3961@2|Bacteria,1MW2F@1224|Proteobacteria,42NMB@68525|delta/epsilon subdivisions,2WKP7@28221|Deltaproteobacteria,2MN6S@213118|Desulfobacterales 28221|Deltaproteobacteria GH Thiamine pyrophosphate enzyme, central domain - - 4.1.1.74 ko:K04103 ko00380,ko01100,map00380,map01100 - R01974 RC00506 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1344858_1 28564.XP_002477873.1 1.09e-06 49.7 KOG0271@1|root,KOG0271@2759|Eukaryota,3AGU6@33154|Opisthokonta,3Q4J3@4751|Fungi,3RMSV@4890|Ascomycota,20U9D@147545|Eurotiomycetes,3SE7S@5042|Eurotiales 4751|Fungi G Encoded by - - - - - - - - - - - - HET,NACHT,PNP_UDP_1,WD40 k59_253121_1 1101195.Meth11DRAFT_1272 2.69e-23 101.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2WEQB@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF,PAS_4 k59_1145329_1 1452718.JBOY01000001_gene591 1.29e-15 76.3 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019897,GO:0019898,GO:0031224,GO:0031226,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033036,GO:0033365,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_1145329_2 697281.Mahau_0657 1.91e-25 102.0 COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,248HW@186801|Clostridia,42EW3@68295|Thermoanaerobacterales 186801|Clostridia D TIGRFAM Cell division ATP-binding protein FtsE ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_1400317_1 1366050.N234_33855 4.86e-13 70.5 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,1K38N@119060|Burkholderiaceae 28216|Betaproteobacteria I Phospholipase D Transphosphatidylase - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_982454_1 1121033.AUCF01000011_gene1793 8.35e-128 375.0 COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,2TQJD@28211|Alphaproteobacteria,2JQ3C@204441|Rhodospirillales 204441|Rhodospirillales P transport system, permease component - - - ko:K13894 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - BPD_transp_1 k59_618804_1 441620.Mpop_3634 1.09e-15 82.4 COG0842@1|root,COG0842@2|Bacteria,1NRMT@1224|Proteobacteria,2U293@28211|Alphaproteobacteria,1JSBI@119045|Methylobacteriaceae 28211|Alphaproteobacteria V PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC2_membrane_3 k59_196766_2 436308.Nmar_1350 1.06e-15 72.8 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1188660_1 1123392.AQWL01000009_gene1112 4.45e-07 50.1 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VS6Z@28216|Betaproteobacteria,1KRXG@119069|Hydrogenophilales 119069|Hydrogenophilales S gag-polyprotein putative aspartyl protease - - - - - - - - - - - - gag-asp_proteas k59_1188660_2 941639.BCO26_2958 2.61e-22 96.3 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,4H9PW@91061|Bacilli,1ZBF9@1386|Bacillus 91061|Bacilli H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS08945 DHBP_synthase,GTP_cyclohydro2 k59_1458885_1 1250005.PHEL85_1695 2.98e-62 207.0 COG4656@1|root,COG4656@2|Bacteria,4NIS7@976|Bacteroidetes,1I7QG@117743|Flavobacteriia 976|Bacteroidetes C Part of a membrane complex involved in electron transport rnfC - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_17,Fer4_7,RnfC_N,SLBB k59_935863_1 1229909.NSED_09130 3.8e-68 214.0 COG1522@1|root,arCOG01586@2157|Archaea,41T3N@651137|Thaumarchaeota 651137|Thaumarchaeota K AsnC-type helix-turn-helix domain - - - - - - - - - - - - HTH_24 k59_935863_2 436308.Nmar_1716 1.72e-59 186.0 COG0494@1|root,arCOG01073@2157|Archaea,41T73@651137|Thaumarchaeota 651137|Thaumarchaeota L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_466229_1 1211112.ALJC01000131_gene3273 2.82e-08 54.3 COG1555@1|root,COG1555@2|Bacteria,1N6Q3@1224|Proteobacteria,1SC7U@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Competence protein ComEA comEA GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3 k59_1551336_2 357808.RoseRS_3848 5.28e-61 208.0 COG0178@1|root,COG0178@2|Bacteria,2G60U@200795|Chloroflexi,3752W@32061|Chloroflexia 32061|Chloroflexia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_308745_2 472759.Nhal_2038 8.51e-22 92.4 COG3193@1|root,COG3193@2|Bacteria,1RK4B@1224|Proteobacteria,1S256@1236|Gammaproteobacteria,1X2KQ@135613|Chromatiales 135613|Chromatiales S Haem-degrading - - - - - - - - - - - - Haem_degrading k59_618839_1 861299.J421_3024 1.23e-78 256.0 COG1012@1|root,COG1012@2|Bacteria,1ZT7A@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_196802_1 414684.RC1_0837 4.99e-72 226.0 COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,2TRRU@28211|Alphaproteobacteria,2JQ4F@204441|Rhodospirillales 204441|Rhodospirillales GK ROK family - - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - ROK k59_982496_1 1173024.KI912148_gene3523 2.02e-79 250.0 COG2403@1|root,COG2403@2|Bacteria,1G1FF@1117|Cyanobacteria 1117|Cyanobacteria S cyclic 2,3-diphosphoglycerate synthetase activity - - - - - - - - - - - - cobW k59_1551361_1 765913.ThidrDRAFT_1095 4.63e-43 155.0 COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,1RR67@1236|Gammaproteobacteria,1WX31@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_1400373_1 330214.NIDE2654 1.12e-28 120.0 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,3J0WW@40117|Nitrospirae 40117|Nitrospirae T Two component signalling adaptor domain - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,HATPase_c,Hpt,Response_reg k59_1344941_1 312284.A20C1_06706 6.19e-58 199.0 COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria,3UWBN@52018|unclassified Actinobacteria (class) 201174|Actinobacteria P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_196824_1 1229909.NSED_08915 2.39e-121 363.0 arCOG08793@1|root,arCOG08812@1|root,arCOG08793@2157|Archaea,arCOG08812@2157|Archaea,41T0K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1092405_1 349124.Hhal_1768 2.55e-46 164.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1WW1H@135613|Chromatiales 135613|Chromatiales G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1092425_1 1320556.AVBP01000001_gene4818 5.93e-24 93.6 COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria,2TRY8@28211|Alphaproteobacteria,43I7Q@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Bacterial extracellular solute-binding protein - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 k59_485234_1 1493510.A0A0E3G5D8_9CAUD 2.67e-23 94.4 4QCT9@10239|Viruses,4QR2V@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_485234_3 444860.E3SJB7_9CAUD 6.32e-56 179.0 4QG51@10239|Viruses,4QXYP@35237|dsDNA viruses no RNA stage,4QPRM@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_6323_1 1155718.KB891877_gene5274 8.67e-26 108.0 COG2220@1|root,COG2220@2|Bacteria,2GNXJ@201174|Actinobacteria 201174|Actinobacteria S Zn-dependent hydrolases of the beta-lactamase fold - - - - - - - - - - - - Lactamase_B_2 k59_694218_1 1280948.HY36_08035 2.07e-51 178.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2TVI8@28211|Alphaproteobacteria,43XT1@69657|Hyphomonadaceae 28211|Alphaproteobacteria G COG2211 Na melibiose symporter and related transporters - - - - - - - - - - - - MFS_2 k59_694218_2 29730.Gorai.005G083900.1 1.14e-79 251.0 COG2513@1|root,KOG1260@2759|Eukaryota,37HN9@33090|Viridiplantae,3GD3G@35493|Streptophyta 35493|Streptophyta C Carboxyvinyl-carboxyphosphonate phosphorylmutase - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464 - - - - - - - - - - PEP_mutase k59_1318066_1 649747.HMPREF0083_05612 1.69e-65 211.0 COG0491@1|root,COG0491@2|Bacteria,1VU7G@1239|Firmicutes,4HU86@91061|Bacilli 91061|Bacilli S 4Fe-4S single cluster domain of Ferredoxin I - - - - - - - - - - - - Fer4_13 k59_430936_1 436308.Nmar_0385 2.18e-77 233.0 COG0080@1|root,arCOG04372@2157|Archaea,41SJW@651137|Thaumarchaeota 651137|Thaumarchaeota J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rpl11 - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_430936_2 436308.Nmar_0383 7.17e-32 114.0 COG1522@1|root,arCOG01580@2157|Archaea,41SJD@651137|Thaumarchaeota 651137|Thaumarchaeota K helix_turn_helix ASNC type - - - ko:K03718 - - - - ko00000,ko03000 - - - AsnC_trans_reg,HTH_24 k59_1579851_1 1121403.AUCV01000001_gene814 2.62e-49 174.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2WJ2W@28221|Deltaproteobacteria,2MHMB@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent Clp protease ATP-binding subunit ClpA clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_274553_1 177437.HRM2_37620 3.3e-57 201.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,42MD4@68525|delta/epsilon subdivisions,2WJ7Z@28221|Deltaproteobacteria,2MIAK@213118|Desulfobacterales 28221|Deltaproteobacteria L TIGRFAM ATP-dependent helicase HrpA hrpA - 3.6.4.13 ko:K03578,ko:K03579 - - - - ko00000,ko01000 - - - AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_1058207_1 1169161.KB897718_gene3467 6.85e-08 59.3 COG0515@1|root,COG0515@2|Bacteria,2IBAC@201174|Actinobacteria 201174|Actinobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_379758_1 1469245.JFBG01000077_gene313 2.6e-135 409.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales 135613|Chromatiales C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_849023_1 243090.RB3373 4.05e-65 226.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0642@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,2J1U9@203682|Planctomycetes 203682|Planctomycetes T AAA ATPase domain - - 2.7.13.3 ko:K02486 - - - - ko00000,ko01000,ko01001,ko02022 - - - AAA_16,HATPase_c,HisKA,Hpt,Pkinase,Response_reg k59_1216968_1 1229909.NSED_08135 2.78e-78 243.0 COG0010@1|root,arCOG01700@2157|Archaea,41T23@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the arginase family - - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_1425232_2 1537994.JQFW01000056_gene734 2.94e-37 138.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1RQGU@1236|Gammaproteobacteria,465Y7@72275|Alteromonadaceae 1236|Gammaproteobacteria E Zn-dependent dipeptidase, microsomal dipeptidase acdP - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_644092_1 269799.Gmet_0133 5.13e-70 232.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2WJG7@28221|Deltaproteobacteria,43STK@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_1579858_1 378806.STAUR_1140 1.84e-152 465.0 COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,42MX2@68525|delta/epsilon subdivisions,2WIUV@28221|Deltaproteobacteria,2YZE4@29|Myxococcales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1371428_1 493475.GARC_2156 6.97e-55 212.0 COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,1T4AK@1236|Gammaproteobacteria,46ACU@72275|Alteromonadaceae 1236|Gammaproteobacteria M OmpA family - - - - - - - - - - - - DUF11,OmpA k59_849035_1 1089552.KI911559_gene2054 8.95e-54 184.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria,2JQ3A@204441|Rhodospirillales 28211|Alphaproteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_6334_1 1415780.JPOG01000001_gene3152 8.56e-56 188.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,1RNDU@1236|Gammaproteobacteria,1XABV@135614|Xanthomonadales 135614|Xanthomonadales I Thiolase, C-terminal domain - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_953049_1 246197.MXAN_2239 1.82e-64 202.0 COG0431@1|root,COG0431@2|Bacteria,1RH7F@1224|Proteobacteria,43B5W@68525|delta/epsilon subdivisions,2X6JG@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Flavodoxin-like fold - - - - - - - - - - - - FMN_red k59_1580629_1 1298858.AUEL01000034_gene3781 1.4e-76 237.0 COG4143@1|root,COG4143@2|Bacteria,1R5K8@1224|Proteobacteria,2U08Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria H (ABC) transporter - - - - - - - - - - - - - k59_1580629_2 1479237.JMLY01000001_gene2626 2.9e-40 147.0 COG2312@1|root,COG2518@1|root,COG2312@2|Bacteria,COG2518@2|Bacteria,1MU2S@1224|Proteobacteria,1RNDR@1236|Gammaproteobacteria,46A50@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - Erythro_esteras,PCMT k59_275405_1 1120973.AQXL01000133_gene1810 2.42e-11 63.5 COG1024@1|root,COG1024@2|Bacteria,1V4YE@1239|Firmicutes,4HTXK@91061|Bacilli,279Y1@186823|Alicyclobacillaceae 91061|Bacilli I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_275405_2 1227487.C474_07432 3.26e-13 70.9 KOG3178@1|root,arCOG07338@2157|Archaea,2XVE6@28890|Euryarchaeota,23U9Z@183963|Halobacteria 183963|Halobacteria G COG3669 Alpha-L-fucosidase - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos,Fucosidase_C k59_802147_1 1487953.JMKF01000095_gene5165 1.32e-21 101.0 COG0745@1|root,COG2199@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1G027@1117|Cyanobacteria,1H8EH@1150|Oscillatoriales 1117|Cyanobacteria T Response regulator receiver domain - - - - - - - - - - - - GAF_2,GGDEF,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg,Trans_reg_C k59_486252_2 384676.PSEEN4484 3.07e-24 101.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the MurCDEF family murC GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iECP_1309.ECP_0093 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1217814_1 1379698.RBG1_1C00001G1055 2.19e-68 220.0 COG1894@1|root,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_1059049_2 331869.BAL199_03554 2.57e-90 282.0 COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,2TR5N@28211|Alphaproteobacteria,4BSA3@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria EH Thiamine pyrophosphate enzyme, N-terminal TPP binding domain MA20_04440 - 2.2.1.6,4.1.1.7 ko:K01576,ko:K01652 ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648 RC00027,RC00106,RC00595,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_N k59_588579_1 1229520.ADIAL_0462 0.000271 43.5 COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,4HAHQ@91061|Bacilli,27H4X@186828|Carnobacteriaceae 91061|Bacilli E Aminotransferase class I and II mtnE - - ko:K08969 ko00270,ko01100,map00270,map01100 M00034 R07396 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_902287_1 562970.Btus_0709 3.21e-52 178.0 COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,4H9MX@91061|Bacilli,277WD@186823|Alicyclobacillaceae 91061|Bacilli E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_380776_1 330214.NIDE1819 3.3e-113 335.0 COG0498@1|root,COG0498@2|Bacteria,3J0FZ@40117|Nitrospirae 40117|Nitrospirae E Pyridoxal-phosphate dependent enzyme thrC1 - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_275416_2 396588.Tgr7_2426 7.47e-60 187.0 COG3118@1|root,COG3118@2|Bacteria,1RHRZ@1224|Proteobacteria,1S7F0@1236|Gammaproteobacteria,1WYEG@135613|Chromatiales 135613|Chromatiales O Belongs to the thioredoxin family - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_168747_1 42256.RradSPS_0729 2.65e-141 438.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4CPS6@84995|Rubrobacteria 84995|Rubrobacteria E B12 binding domain - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_645095_1 1123377.AUIV01000003_gene1852 8.07e-25 102.0 COG0835@1|root,COG0835@2|Bacteria,1RCIR@1224|Proteobacteria,1S61F@1236|Gammaproteobacteria,1X5IW@135614|Xanthomonadales 135614|Xanthomonadales NT chemotaxis signal transduction protein pilI - - ko:K02659 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - CheW k59_118584_1 1550091.JROE01000022_gene3314 1.53e-40 153.0 COG0616@1|root,COG0616@2|Bacteria,4NES1@976|Bacteroidetes,1IP6H@117747|Sphingobacteriia 976|Bacteroidetes OU signal peptide peptidase SppA, 67K type sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_118586_1 1116472.MGMO_11c00360 9.08e-88 288.0 COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PE6F@1224|Proteobacteria,1RWQP@1236|Gammaproteobacteria,1XDNM@135618|Methylococcales 1236|Gammaproteobacteria CEH 2 iron, 2 sulfur cluster binding - - - - - - - - - - - - - k59_1633939_1 1396141.BATP01000007_gene5667 2.25e-11 64.3 COG0404@1|root,COG0404@2|Bacteria,46UPA@74201|Verrucomicrobia,2ITVC@203494|Verrucomicrobiae 203494|Verrucomicrobiae E Aminomethyltransferase folate-binding domain gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_1633939_2 1121405.dsmv_2237 3.83e-38 133.0 COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,42W8P@68525|delta/epsilon subdivisions,2WRV4@28221|Deltaproteobacteria,2MKN4@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM NUDIX hydrolase nudF - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_1318660_1 445686.E3SL91_9CAUD 1.62e-67 216.0 4QCGC@10239|Viruses,4QZFA@35237|dsDNA viruses no RNA stage,4QTZH@28883|Caudovirales,4QJ8J@10662|Myoviridae 10662|Myoviridae S Domain of unknown function (DUF4338) - - - - - - - - - - - - - k59_1318660_2 444878.E3SR41_9CAUD 2.22e-43 145.0 4QBC7@10239|Viruses,4QUQW@35237|dsDNA viruses no RNA stage,4QPGT@28883|Caudovirales 28883|Caudovirales S Pfam:Phage_clamp_A - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_1318660_3 445686.E3SL93_9CAUD 6.42e-85 252.0 4QBKQ@10239|Viruses,4QVKF@35237|dsDNA viruses no RNA stage,4QQM7@28883|Caudovirales,4QIAS@10662|Myoviridae 10662|Myoviridae S Bacteriophage translational regulator - - - - - - - - - - - - - k59_380801_1 1096769.Pelub83DRAFT_0471 3.44e-99 311.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,4BPQB@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the GcvT family dmgdh2 - 1.5.8.4 ko:K00315 ko00260,ko01100,map00260,map01100 - R01565 RC00181 ko00000,ko00001,ko01000 - - - DAO,FAO_M,GCV_T,GCV_T_C k59_802189_1 396588.Tgr7_1237 1.45e-97 298.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1WWI5@135613|Chromatiales 135613|Chromatiales H Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - - - - - - - - - - HemN_C,Radical_SAM k59_486297_1 1485544.JQKP01000001_gene928 9.81e-68 229.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,44VDQ@713636|Nitrosomonadales 28216|Betaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_588625_1 1144275.COCOR_00125 1.16e-40 152.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,42N1B@68525|delta/epsilon subdivisions,2WJWS@28221|Deltaproteobacteria,2YTWC@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_536222_1 317655.Sala_3101 1.22e-22 94.7 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2U787@28211|Alphaproteobacteria,2K074@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_Omp,OmpA k59_431832_1 1239962.C943_01325 3.19e-72 234.0 COG0405@1|root,COG0405@2|Bacteria,4NF2H@976|Bacteroidetes,47K06@768503|Cytophagia 976|Bacteroidetes E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_328177_1 316067.Geob_3836 1.97e-58 198.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,42KZC@68525|delta/epsilon subdivisions,2WJ31@28221|Deltaproteobacteria,43TF6@69541|Desulfuromonadales 28221|Deltaproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_328177_2 690850.Desaf_1417 0.000113 43.5 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,42M6T@68525|delta/epsilon subdivisions,2WIWY@28221|Deltaproteobacteria,2M8QB@213115|Desulfovibrionales 28221|Deltaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_745206_1 1437425.CSEC_2141 2.55e-102 316.0 COG0058@1|root,COG0058@2|Bacteria,2JFEH@204428|Chlamydiae 204428|Chlamydiae G Carbohydrate phosphorylase glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_168793_2 525897.Dbac_0954 1.52e-10 59.3 COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WR88@28221|Deltaproteobacteria,2MDMW@213115|Desulfovibrionales 28221|Deltaproteobacteria T Universal stress protein - - - - - - - - - - - - Usp k59_1271908_1 436308.Nmar_1766 3.72e-71 233.0 arCOG02362@1|root,arCOG07810@1|root,arCOG02362@2157|Archaea,arCOG07810@2157|Archaea,41T0S@651137|Thaumarchaeota 651137|Thaumarchaeota N Adenylate guanylate cyclase with integral membrane sensor - - - - - - - - - - - - Guanylate_cyc,HAMP k59_1162078_1 1589747.A0A0B5A4I4_9CAUD 1.14e-42 166.0 4QAKM@10239|Viruses,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_1372260_1 398767.Glov_1916 4.68e-19 92.0 COG1192@1|root,COG1192@2|Bacteria,1NPCB@1224|Proteobacteria,42Y7J@68525|delta/epsilon subdivisions,2WUHN@28221|Deltaproteobacteria,43T7Q@69541|Desulfuromonadales 28221|Deltaproteobacteria D NUBPL iron-transfer P-loop NTPase - - - - - - - - - - - - AAA_31 k59_1162081_1 717785.HYPMC_2722 9.01e-28 114.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2TVNW@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Rieske 2Fe-2S - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_380846_1 1123393.KB891326_gene211 8.01e-17 78.6 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,2VSE2@28216|Betaproteobacteria,1KT8A@119069|Hydrogenophilales 119069|Hydrogenophilales H 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) - - - - - - - - - - - - HPPK k59_380846_2 765910.MARPU_15110 1.34e-44 159.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales 135613|Chromatiales J Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_70507_1 118166.JH976537_gene676 4.1e-52 169.0 COG4101@1|root,COG4101@2|Bacteria,1G64Q@1117|Cyanobacteria,1HFQH@1150|Oscillatoriales 1117|Cyanobacteria G Cupin - - - - - - - - - - - - Cupin_2 k59_1059121_1 530564.Psta_4116 8.17e-40 140.0 2E13Z@1|root,32WJ8@2|Bacteria,2J0YS@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - k59_1059121_2 3055.EDP06963 2.65e-07 57.8 COG0519@1|root,KOG1622@2759|Eukaryota,37KGG@33090|Viridiplantae,34HAJ@3041|Chlorophyta 3041|Chlorophyta F GMP synthase C terminal domain - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_588646_1 1231185.BAMP01000001_gene4314 3.84e-74 240.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_1580705_1 234267.Acid_5837 3.41e-105 341.0 COG1201@1|root,COG1201@2|Bacteria,3Y348@57723|Acidobacteria 57723|Acidobacteria L DEAD DEAH box - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_118646_1 323261.Noc_2487 3.65e-77 244.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1WWTN@135613|Chromatiales 135613|Chromatiales E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5,SufE k59_902353_1 316067.Geob_3632 5.88e-145 446.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,43T41@69541|Desulfuromonadales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1426277_1 159450.NH14_20430 1.14e-247 700.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2VZAM@28216|Betaproteobacteria,1K5X3@119060|Burkholderiaceae 28216|Betaproteobacteria C Flavin-binding monooxygenase-like - - 1.14.13.84 ko:K14520 ko00363,ko01100,ko01120,map00363,map01100,map01120 - R06892 RC01644 ko00000,ko00001,ko01000 - - - FMO-like k59_1426277_2 1150399.AQYK01000001_gene1863 7.99e-06 47.4 COG0596@1|root,COG0596@2|Bacteria,2GK79@201174|Actinobacteria,4FKCC@85023|Microbacteriaceae 201174|Actinobacteria S Epoxide hydrolase N terminus - - - - - - - - - - - - EHN k59_223191_1 390874.Tpet_0225 3.89e-35 128.0 COG1136@1|root,COG1136@2|Bacteria,2GCNW@200918|Thermotogae 200918|Thermotogae V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_168817_1 396588.Tgr7_2621 3.68e-76 239.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1WX3A@135613|Chromatiales 135613|Chromatiales D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_1318694_1 547042.BACCOPRO_01336 4.44e-12 67.4 COG0769@1|root,COG0769@2|Bacteria,4NE9W@976|Bacteroidetes,2FM8E@200643|Bacteroidia,4AN1V@815|Bacteroidaceae 976|Bacteroidetes M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1318694_2 713586.KB900536_gene1379 1.14e-136 407.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1WWDS@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_849917_1 1408424.JHYI01000026_gene907 3.56e-60 206.0 COG1061@1|root,COG4951@1|root,COG1061@2|Bacteria,COG4951@2|Bacteria,1TS5R@1239|Firmicutes,4HCVA@91061|Bacilli,1ZQHG@1386|Bacillus 91061|Bacilli L Type III restriction protein res subunit XK27_08510 - - - - - - - - - - - Helicase_C,ResIII k59_745228_1 1454004.AW11_02854 6.22e-77 246.0 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2VP1W@28216|Betaproteobacteria 28216|Betaproteobacteria CP Proton-conducting membrane transporter - - - - - - - - - - - - Proton_antipo_M k59_70530_1 383372.Rcas_0654 2.62e-103 308.0 COG0714@1|root,COG0714@2|Bacteria,2G5WI@200795|Chloroflexi,374WI@32061|Chloroflexia 32061|Chloroflexia S PFAM ATPase associated with various cellular activities, AAA_5 - - - - - - - - - - - - AAA_5 k59_1634029_1 240016.ABIZ01000001_gene839 9.84e-54 179.0 COG0026@1|root,COG0026@2|Bacteria,46SG7@74201|Verrucomicrobia,2ITZP@203494|Verrucomicrobiae 203494|Verrucomicrobiae F ATP-grasp domain - - - - - - - - - - - - ATP-grasp k59_130888_2 926556.Echvi_1526 2.49e-11 62.4 COG0297@1|root,COG0297@2|Bacteria,4NFP8@976|Bacteroidetes,47KUD@768503|Cytophagia 976|Bacteroidetes G PFAM Starch synthase catalytic domain glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5 k59_815593_1 243159.AFE_0425 1.16e-18 85.1 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,2NCHJ@225057|Acidithiobacillales 225057|Acidithiobacillales F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_176898_1 1459636.NTE_01702 2.97e-91 275.0 COG0379@1|root,arCOG04459@2157|Archaea,41S6Y@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_1531717_1 1157490.EL26_13245 1.38e-23 102.0 COG1960@1|root,COG1960@2|Bacteria,1TSN3@1239|Firmicutes,4HB0T@91061|Bacilli,278X4@186823|Alicyclobacillaceae 91061|Bacilli I PFAM acyl-CoA dehydrogenase domain protein - - 1.3.8.7 ko:K00249,ko:K11731 ko00071,ko00280,ko00281,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00281,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R08089 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246,RC01893 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_963709_2 998674.ATTE01000001_gene2788 7.53e-44 152.0 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,460JH@72273|Thiotrichales 72273|Thiotrichales O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_443635_1 1323663.AROI01000035_gene1306 4.64e-91 290.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria H acetolactate synthase ilvI GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1907,iB21_1397.B21_00078,iBWG_1329.BWG_0073,iECBD_1354.ECBD_3539,iECB_1328.ECB_00079,iECD_1391.ECD_00079,iUTI89_1310.UTI89_C0085,iYL1228.KPN_00082 TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1326284_1 1121033.AUCF01000008_gene5670 1.32e-35 136.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,2JQVC@204441|Rhodospirillales 204441|Rhodospirillales P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_338169_1 765912.Thimo_3676 2.22e-27 107.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1WW5T@135613|Chromatiales 135613|Chromatiales F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD - 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_338169_2 377629.TERTU_1095 3.09e-35 124.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,2PNH0@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J SpoU rRNA Methylase family trmL GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_598692_1 396588.Tgr7_0751 1.98e-56 183.0 COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1WWVP@135613|Chromatiales 135613|Chromatiales C PFAM Cytochrome C1 petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C1 k59_1493181_2 330214.NIDE2073 7.38e-19 86.7 COG1389@1|root,COG1389@2|Bacteria 2|Bacteria L DNA topoisomerase II activity top6B - 5.99.1.3 ko:K03167 - - - - ko00000,ko01000,ko03032 - - - HATPase_c,HATPase_c_3,Topo-VIb_trans k59_1285597_1 330214.NIDE4396 5.8e-100 303.0 COG1351@1|root,COG1351@2|Bacteria 2|Bacteria F thymidylate synthase (FAD) activity thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_658561_1 626418.bglu_2g22300 5.48e-21 92.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VIK6@28216|Betaproteobacteria,1K0WB@119060|Burkholderiaceae 28216|Betaproteobacteria S biosynthesis protein E pqqE - - ko:K06139 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_658561_2 96561.Dole_2292 5.07e-26 115.0 COG0025@1|root,COG0569@1|root,COG0025@2|Bacteria,COG0569@2|Bacteria,1QTUE@1224|Proteobacteria,43BRM@68525|delta/epsilon subdivisions,2WM4A@28221|Deltaproteobacteria,2MHXR@213118|Desulfobacterales 28221|Deltaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger,TrkA_N k59_963730_1 436308.Nmar_1233 1.01e-72 222.0 COG1909@1|root,arCOG04076@2157|Archaea,41SNQ@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the UPF0218 family - - - ko:K09735 - - - - ko00000 - - - DUF359 k59_860259_1 760568.Desku_3526 8.6e-25 108.0 COG3119@1|root,COG3119@2|Bacteria,1VAJC@1239|Firmicutes,24C1C@186801|Clostridia 186801|Clostridia P Sulfatase - - - - - - - - - - - - Sulfatase k59_755254_1 1229909.NSED_01155 9.88e-124 358.0 COG0115@1|root,arCOG02297@2157|Archaea,41S5T@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_1591086_1 745411.B3C1_02485 4.07e-48 159.0 COG2930@1|root,COG2930@2|Bacteria,1RCYH@1224|Proteobacteria,1S41U@1236|Gammaproteobacteria,1J6CJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S s cog2930 CT2216 - - - - - - - - - - - Ysc84 k59_1326312_1 518766.Rmar_0188 1.98e-86 265.0 COG2897@1|root,COG2897@2|Bacteria,4NF85@976|Bacteroidetes 976|Bacteroidetes P sulfurtransferase sseA - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_545900_1 309807.SRU_2383 2.79e-45 166.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,4NERT@976|Bacteroidetes,1FJ3R@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes MU WD40-like Beta Propeller Repeat - - - - - - - - - - - - BSP,Bac_surface_Ag,PD40 k59_11291_3 1894.JOER01000002_gene3492 6.39e-06 45.1 COG2343@1|root,COG2343@2|Bacteria 2|Bacteria S Domain of unknown function (DUF427) - - - - - - - - - - - - NTP_transf_9 k59_658588_1 1229909.NSED_09745 1.06e-90 278.0 COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger k59_232899_1 298655.KI912266_gene4987 8.38e-110 329.0 COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,4ETPN@85013|Frankiales 201174|Actinobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_815670_1 690850.Desaf_2905 3.24e-54 191.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,2M8QF@213115|Desulfovibrionales 28221|Deltaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_1591110_1 1408452.JAGZ01000001_gene3124 0.000476 46.2 COG3424@1|root,COG3424@2|Bacteria,2GV0U@201174|Actinobacteria,235DU@1762|Mycobacteriaceae 201174|Actinobacteria Q synthase pks11 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006725,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009698,GO:0009699,GO:0009714,GO:0009715,GO:0009987,GO:0016043,GO:0019438,GO:0019748,GO:0022607,GO:0032991,GO:0034081,GO:0042180,GO:0042181,GO:0042546,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:1901360,GO:1901362,GO:1901576 - ko:K16167 - - - - ko00000,ko01008 - - - Chal_sti_synt_C,Chal_sti_synt_N k59_1591110_2 1150599.MPHLEI_09969 1.19e-22 98.2 COG2124@1|root,COG2124@2|Bacteria,2GM1R@201174|Actinobacteria,2345X@1762|Mycobacteriaceae 201174|Actinobacteria Q cytochrome p450 cyp191A3 - - - - - - - - - - - p450 k59_860289_1 351348.Maqu_3434 8.24e-12 62.8 COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,1SCBI@1236|Gammaproteobacteria,468PG@72275|Alteromonadaceae 1236|Gammaproteobacteria D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division zapA GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000921,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032185,GO:0032505,GO:0032506,GO:0034622,GO:0042802,GO:0043093,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051301,GO:0061640,GO:0065003,GO:0070925,GO:0071840,GO:0090529,GO:1902410,GO:1903047 - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_860289_2 2340.JV46_21510 9.54e-45 148.0 COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,1S68X@1236|Gammaproteobacteria,1J5YH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S EVE domain - - - - - - - - - - - - EVE k59_1169941_1 1300345.LF41_470 1.2e-61 209.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1X3ZE@135614|Xanthomonadales 135614|Xanthomonadales KL Helicase yoaA - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,Helicase_C_2,ResIII k59_1439430_1 156889.Mmc1_2551 1.07e-59 196.0 COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,2U24Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Integrase - - - - - - - - - - - - HTH_32,rve,rve_3 k59_860293_2 1121413.JMKT01000015_gene284 1.83e-27 112.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria,2M88F@213115|Desulfovibrionales 28221|Deltaproteobacteria E TIGRFAM asparagine synthase (glutamine-hydrolyzing) - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_338223_1 604331.AUHY01000005_gene758 1.05e-55 190.0 COG1472@1|root,COG1472@2|Bacteria,1WIIA@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G PFAM Glycosyl hydrolase family 3 N terminal domain - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_285957_1 882086.SacxiDRAFT_3002 1.2e-57 189.0 COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4DX3Z@85010|Pseudonocardiales 201174|Actinobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_443708_1 1163617.SCD_n02628 1.04e-54 187.0 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,2VMDE@28216|Betaproteobacteria 28216|Betaproteobacteria N transport system - - - - - - - - - - - - ABC_transp_aux k59_658622_1 305900.GV64_06040 6.13e-56 191.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1XHE2@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_658622_2 1123020.AUIE01000022_gene3061 3.6e-11 63.2 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1YD08@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Belongs to the FPP GGPP synthase family ispA GO:0003674,GO:0003824,GO:0004161,GO:0004337,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033383,GO:0033384,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045337,GO:0045338,GO:0071704,GO:0090407,GO:1901576 2.5.1.1,2.5.1.10,2.5.1.29 ko:K00795,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - iPC815.YPO3176,iSFV_1184.SFV_0386 polyprenyl_synt k59_1230070_1 1172190.M947_10975 5.2e-08 60.5 COG1670@1|root,COG1670@2|Bacteria 2|Bacteria J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins cysE - 2.3.1.178 ko:K06718 ko00260,ko01100,ko01120,map00260,map01100,map01120 M00033 R06978 RC00004,RC00096 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1 k59_443714_1 713586.KB900536_gene2033 5.58e-47 154.0 COG0735@1|root,COG0735@2|Bacteria,1RH58@1224|Proteobacteria,1SAXA@1236|Gammaproteobacteria 1236|Gammaproteobacteria P belongs to the Fur family - - - ko:K09826 - - - - ko00000,ko03000 - - - FUR k59_658625_1 42565.FP66_15220 1.01e-15 74.7 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,1XH4S@135619|Oceanospirillales 135619|Oceanospirillales H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_23 k59_658625_2 1005048.CFU_3760 2.54e-47 160.0 COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,2VS13@28216|Betaproteobacteria,473BT@75682|Oxalobacteraceae 28216|Betaproteobacteria S haloacid dehalogenase-like hydrolase gph - 3.1.3.105 ko:K22292 ko00520,map00520 - R11785 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_815699_2 243090.RB6466 7.11e-09 56.2 COG1217@1|root,COG1217@2|Bacteria,2IY3Q@203682|Planctomycetes 203682|Planctomycetes T membrane GTPase involved in stress response typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_815702_2 203122.Sde_2766 1.58e-64 201.0 COG3350@1|root,COG3350@2|Bacteria,1N0GC@1224|Proteobacteria,1S7V6@1236|Gammaproteobacteria,46863@72275|Alteromonadaceae 1236|Gammaproteobacteria S YHS domain - - - - - - - - - - - - YHS k59_338239_1 885272.JonanDRAFT_1314 1.18e-54 187.0 COG0168@1|root,COG0168@2|Bacteria,3T9WI@508458|Synergistetes 508458|Synergistetes P Potassium uptake protein, TrkH family - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_83877_1 167539.Pro_1265 1.22e-38 152.0 28JA7@1|root,2Z951@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - CotH k59_1326349_1 1279009.ADICEAN_00647 2.34e-64 205.0 COG3228@1|root,COG3228@2|Bacteria,4NMII@976|Bacteroidetes,47QA7@768503|Cytophagia 976|Bacteroidetes S Glucose-regulated metallo-peptidase M90 - - - ko:K09933 - - - - ko00000,ko01002 - - - Peptidase_M90 k59_545941_1 195253.Syn6312_3143 2.24e-24 99.8 COG3153@1|root,COG3153@2|Bacteria,1GK4Y@1117|Cyanobacteria,1H22G@1129|Synechococcus 1117|Cyanobacteria S Acetyltransferase (GNAT) family - - - ko:K03824 - - - - ko00000,ko01000 - - - Acetyltransf_9 k59_391834_1 713587.THITH_06480 2.03e-67 219.0 COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,1T20U@1236|Gammaproteobacteria,1WY2T@135613|Chromatiales 135613|Chromatiales C PFAM Nickel-dependent hydrogenase, large subunit - - - - - - - - - - - - NiFeSe_Hases k59_232939_1 443152.MDG893_15342 5.6e-59 192.0 COG0697@1|root,COG0697@2|Bacteria,1RFV1@1224|Proteobacteria 1224|Proteobacteria EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_1326354_1 497965.Cyan7822_2623 9.93e-44 161.0 COG3290@1|root,COG5001@1|root,COG3290@2|Bacteria,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria,3KG35@43988|Cyanothece 1117|Cyanobacteria T GGDEF domain containing protein - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_912758_1 1071400.LBUCD034_0403 7.02e-13 66.6 COG0041@1|root,COG0041@2|Bacteria,1V1MV@1239|Firmicutes,4HFR7@91061|Bacilli,3F6P0@33958|Lactobacillaceae 91061|Bacilli F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_912758_2 1345695.CLSA_c10210 3.1e-105 338.0 COG1038@1|root,COG1038@2|Bacteria,1UHP9@1239|Firmicutes,25E5B@186801|Clostridia,36UMQ@31979|Clostridiaceae 186801|Clostridia C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second pyc - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS18410 Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA k59_1121382_1 330214.NIDE2642 2.41e-64 208.0 COG0795@1|root,COG0795@2|Bacteria,3J0S0@40117|Nitrospirae 40117|Nitrospirae S Predicted permease YjgP/YjgQ family - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1230104_1 713586.KB900536_gene1835 8.11e-59 205.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1WWYN@135613|Chromatiales 135613|Chromatiales U type IV pilus secretin PilQ - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_1230106_1 177437.HRM2_00920 6.89e-58 195.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MU2@68525|delta/epsilon subdivisions,2WM00@28221|Deltaproteobacteria,2MKCR@213118|Desulfobacterales 28221|Deltaproteobacteria M Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1326360_1 1469245.JFBG01000010_gene593 4.33e-112 329.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1WWQE@135613|Chromatiales 1236|Gammaproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus - - - - - - - - - - - - Epimerase,Formyl_trans_C,Formyl_trans_N k59_1285708_1 247634.GPB2148_549 4.65e-29 116.0 COG1073@1|root,COG1073@2|Bacteria,1PQAX@1224|Proteobacteria,1S02C@1236|Gammaproteobacteria,1J81R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S alpha beta - - - - - - - - - - - - DUF2048 k59_177854_1 1122176.KB903533_gene2317 2.13e-59 200.0 COG0462@1|root,COG0462@2|Bacteria,4NFX7@976|Bacteroidetes,1IVYQ@117747|Sphingobacteriia 976|Bacteroidetes EF Belongs to the ribose-phosphate pyrophosphokinase family - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran,Pribosyltran_N k59_1494681_1 1537994.JQFW01000004_gene3219 7.27e-06 52.0 COG1309@1|root,COG1309@2|Bacteria,1R4DQ@1224|Proteobacteria,1S16C@1236|Gammaproteobacteria,46CX4@72275|Alteromonadaceae 1236|Gammaproteobacteria K transcriptional regulator - - - ko:K09017 - - - - ko00000,ko03000 - - - TetR_C_3,TetR_N k59_11754_2 1131462.DCF50_p2074 0.000113 44.7 COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,261CK@186807|Peptococcaceae 186801|Clostridia M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_132394_2 1123376.AUIU01000011_gene919 2.07e-57 193.0 COG5557@1|root,COG5557@2|Bacteria 2|Bacteria C Polysulphide reductase, NrfD hmcC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - NrfD k59_445136_1 1137799.GZ78_22295 1.93e-15 74.3 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1XH68@135619|Oceanospirillales 135619|Oceanospirillales C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_445136_2 187272.Mlg_2874 5.23e-31 111.0 COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,1S9MD@1236|Gammaproteobacteria,1WYXA@135613|Chromatiales 135613|Chromatiales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_547019_1 404589.Anae109_1883 5.02e-83 257.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,42MB0@68525|delta/epsilon subdivisions,2WJ42@28221|Deltaproteobacteria,2YWE0@29|Myxococcales 28221|Deltaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF987.Gmet_1415 Phe_tRNA-synt_N,tRNA-synt_2d k59_547019_2 1121406.JAEX01000001_gene7 5.98e-77 256.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria,2M81Z@213115|Desulfovibrionales 28221|Deltaproteobacteria J TIGRFAM phenylalanyl-tRNA synthetase, beta subunit pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_1494704_1 8090.ENSORLP00000011903 2.76e-47 173.0 COG1012@1|root,KOG2452@2759|Eukaryota,39MAJ@33154|Opisthokonta,3BCUT@33208|Metazoa,3CY12@33213|Bilateria,487KE@7711|Chordata,48XCX@7742|Vertebrata,49SBU@7898|Actinopterygii 33208|Metazoa F Aldehyde dehydrogenase 1 family, member L1 ALDH1L1 GO:0003674,GO:0003824,GO:0004029,GO:0004030,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009109,GO:0009256,GO:0009258,GO:0009396,GO:0009397,GO:0009987,GO:0016053,GO:0016054,GO:0016155,GO:0016491,GO:0016620,GO:0016645,GO:0016646,GO:0016903,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0019752,GO:0032991,GO:0033721,GO:0034641,GO:0042219,GO:0042398,GO:0042558,GO:0042559,GO:0042560,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046394,GO:0046395,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046700,GO:0051186,GO:0051187,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 1.5.1.6 ko:K00289 ko00670,map00670 - R00941 RC00026 ko00000,ko00001,ko01000 - - - Aldedh,Formyl_trans_C,Formyl_trans_N,PP-binding k59_1017706_1 1340493.JNIF01000003_gene2870 1.58e-55 192.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,3Y3QY@57723|Acidobacteria 57723|Acidobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_501327_1 999549.KI421513_gene2108 2.86e-105 322.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2TSZY@28211|Alphaproteobacteria,27ZH3@191028|Leisingera 28211|Alphaproteobacteria E Glu/Leu/Phe/Val dehydrogenase, dimerisation domain gdh - 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N,Response_reg k59_756452_2 224324.aq_473 1.8e-75 233.0 COG3063@1|root,COG3063@2|Bacteria 2|Bacteria NU photosynthesis - - - - - - - - - - - - Peptidase_C39_2,TPR_16,TPR_19,TPR_2,TPR_8 k59_1241291_2 1125863.JAFN01000001_gene311 1.31e-41 145.0 COG0461@1|root,COG0461@2|Bacteria,1PI8N@1224|Proteobacteria,42QSR@68525|delta/epsilon subdivisions,2WMT5@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_16427_1 324925.Ppha_2908 8.57e-06 52.4 COG3339@1|root,COG3339@2|Bacteria,1FE15@1090|Chlorobi 1090|Chlorobi S Protein of unknown function (DUF1232) - - - - - - - - - - - - DUF1232 k59_1448733_1 316067.Geob_1098 3.5e-22 92.4 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,42R5H@68525|delta/epsilon subdivisions,2WNZS@28221|Deltaproteobacteria,43UVU@69541|Desulfuromonadales 28221|Deltaproteobacteria M PFAM OmpA MotB domain protein pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_671593_1 1124780.ANNU01000072_gene1060 2.04e-22 101.0 COG1409@1|root,COG4775@1|root,COG1409@2|Bacteria,COG4775@2|Bacteria,4NF9N@976|Bacteroidetes,47JAP@768503|Cytophagia 976|Bacteroidetes M Calcineurin-like phosphoesterase - - - - - - - - - - - - Bac_surface_Ag,Metallophos,ShlB k59_455148_1 330779.Saci_0366 1.93e-40 146.0 COG2057@1|root,arCOG05316@2157|Archaea,2XQWQ@28889|Crenarchaeota 28889|Crenarchaeota I PFAM Coenzyme A transferase - - 2.8.3.12 ko:K01040 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_1080939_2 1254432.SCE1572_00290 3.75e-14 76.6 COG0517@1|root,COG0517@2|Bacteria,1QZT1@1224|Proteobacteria,43CN4@68525|delta/epsilon subdivisions,2X7VC@28221|Deltaproteobacteria,2Z3IG@29|Myxococcales 28221|Deltaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_242399_1 768671.ThimaDRAFT_0202 2.63e-48 170.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,1WXJN@135613|Chromatiales 135613|Chromatiales I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1659476_1 983545.Glaag_2589 3.14e-26 109.0 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,1RQRT@1236|Gammaproteobacteria,466FW@72275|Alteromonadaceae 1236|Gammaproteobacteria O Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_400187_1 858619.CVAR_2743 1.16e-27 113.0 COG0345@1|root,COG0345@2|Bacteria,2GJ7D@201174|Actinobacteria,22JUP@1653|Corynebacteriaceae 201174|Actinobacteria E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_400187_2 1122132.AQYH01000018_gene1192 1.9e-12 66.2 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2TR5Z@28211|Alphaproteobacteria,4B7MG@82115|Rhizobiaceae 28211|Alphaproteobacteria S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_1025427_1 930169.B5T_03201 2.5e-51 165.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,1XJKA@135619|Oceanospirillales 135619|Oceanospirillales J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT - - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_1025427_2 1286170.RORB6_04050 5.07e-16 72.8 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_455162_1 1121413.JMKT01000012_gene577 8.35e-73 228.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,42N9Z@68525|delta/epsilon subdivisions,2WIKQ@28221|Deltaproteobacteria,2M9HW@213115|Desulfovibrionales 28221|Deltaproteobacteria I PFAM 6-phosphogluconate dehydrogenase NAD-binding - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1539976_1 1123257.AUFV01000016_gene3473 3.82e-14 72.4 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1X3IM@135614|Xanthomonadales 135614|Xanthomonadales S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_714516_1 395965.Msil_0426 3.01e-47 165.0 COG0174@1|root,COG0174@2|Bacteria,1NZU7@1224|Proteobacteria,2TS0B@28211|Alphaproteobacteria 28211|Alphaproteobacteria E glutamine synthetase glnII - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_555376_1 479432.Sros_8194 1.49e-137 399.0 COG0183@1|root,COG0183@2|Bacteria,2GKFR@201174|Actinobacteria,4EHJE@85012|Streptosporangiales 201174|Actinobacteria I lipid-transfer protein ltp2 - - - - - - - - - - - Thiolase_N k59_297337_1 237368.SCABRO_03617 7.48e-15 74.7 COG1310@1|root,COG1310@2|Bacteria,2J1CP@203682|Planctomycetes 203682|Planctomycetes S JAB/MPN domain - - - - - - - - - - - - Prok-JAB k59_297337_2 1046724.KB889900_gene3205 4.02e-27 111.0 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,46AKM@72275|Alteromonadaceae 1236|Gammaproteobacteria H ThiF family moeB - 2.7.7.80,2.8.1.11 ko:K21029,ko:K21147 ko04122,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - Prok-JAB,Rhodanese,ThiF,ThiS k59_924406_1 1469245.JFBG01000014_gene2027 1.52e-127 378.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RMQB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tripartite tricarboxylate transporter TctA - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_1133035_1 469616.FMAG_01322 3.09e-23 101.0 COG1190@1|root,COG1190@2|Bacteria,37904@32066|Fusobacteria 32066|Fusobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_1539990_1 553184.ATORI0001_1039 2.11e-05 52.4 COG0488@1|root,COG0488@2|Bacteria,2GKZC@201174|Actinobacteria,4CUWH@84998|Coriobacteriia 84998|Coriobacteriia S ABC transporter - - - - - - - - - - - - ABC_tran k59_671658_1 1211114.ALIP01000003_gene2791 4.84e-08 54.3 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,1RNTZ@1236|Gammaproteobacteria,1X4BE@135614|Xanthomonadales 135614|Xanthomonadales O Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_1334773_1 298655.KI912266_gene1621 6.24e-22 102.0 COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4EUIB@85013|Frankiales 201174|Actinobacteria L PFAM transposase mutator type - - - - - - - - - - - - Transposase_mut k59_607222_1 1121403.AUCV01000007_gene1279 3.29e-70 227.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MPSH@213118|Desulfobacterales 28221|Deltaproteobacteria T Sigma-54 interaction domain - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1025470_1 502025.Hoch_6423 1.22e-113 337.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42NY7@68525|delta/epsilon subdivisions,2WIXK@28221|Deltaproteobacteria,2YU5U@29|Myxococcales 28221|Deltaproteobacteria L Endonuclease/Exonuclease/phosphatase family exoA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_1025470_2 1337936.IJ00_10310 2.67e-09 57.0 COG1830@1|root,COG1830@2|Bacteria,1G1ER@1117|Cyanobacteria,1HKSS@1161|Nostocales 1117|Cyanobacteria G PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase fbaB - 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - DeoC k59_1448783_1 472759.Nhal_0334 7.34e-57 192.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1WVZD@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_1178594_2 525904.Tter_0637 2.32e-40 148.0 COG0530@1|root,COG0530@2|Bacteria,2NPSH@2323|unclassified Bacteria 2|Bacteria P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_142104_3 395495.Lcho_3891 7.31e-60 191.0 COG1999@1|root,COG1999@2|Bacteria,1REUE@1224|Proteobacteria,2WA2J@28216|Betaproteobacteria,1KNIJ@119065|unclassified Burkholderiales 28216|Betaproteobacteria S SCO1/SenC - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_1659556_1 1968.JOEV01000001_gene7568 3.89e-14 77.0 COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1600572_1 888052.HMPREF9006_0444 1.22e-26 113.0 COG2176@1|root,COG2176@2|Bacteria,2I2FU@201174|Actinobacteria,4D80I@85005|Actinomycetales 201174|Actinobacteria L EXOIII - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - GIY-YIG,RNase_T k59_925546_1 1517681.HW45_22110 1.85e-42 145.0 COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,1S682@1236|Gammaproteobacteria,1XSNS@135623|Vibrionales 135623|Vibrionales S protein conserved in bacteria TLL0138 - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_870240_1 1408444.JHYC01000007_gene2196 1.59e-46 168.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1JDJZ@118969|Legionellales 118969|Legionellales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_350607_1 1468411.X2KTX4_9CAUD 0.000158 47.8 4QFXT@10239|Viruses,4QRG1@28883|Caudovirales,4QM7W@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_186086_1 105559.Nwat_2495 8.32e-151 436.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1WWJU@135613|Chromatiales 135613|Chromatiales H PFAM Aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1300225_1 693661.Arcve_0343 4.59e-35 124.0 COG0607@1|root,arCOG02021@2157|Archaea,2XY1R@28890|Euryarchaeota,246BX@183980|Archaeoglobi 183980|Archaeoglobi P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_1507835_1 395494.Galf_1394 2.11e-38 139.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,44VKE@713636|Nitrosomonadales 28216|Betaproteobacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_1540962_1 266117.Rxyl_0134 7.08e-37 136.0 COG1409@1|root,COG1409@2|Bacteria,2GU3Z@201174|Actinobacteria 201174|Actinobacteria S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos,Metallophos_2 k59_974196_1 450851.PHZ_c1574 3.47e-59 200.0 COG0183@1|root,COG0183@2|Bacteria,1MVPC@1224|Proteobacteria,2VEVD@28211|Alphaproteobacteria,2KF3X@204458|Caulobacterales 204458|Caulobacterales I acetyl-coa acetyltransferase - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - - k59_243603_1 1121440.AUMA01000002_gene2107 1.4e-81 248.0 COG1083@1|root,COG1083@2|Bacteria,1RHF3@1224|Proteobacteria,42XE9@68525|delta/epsilon subdivisions,2WXAN@28221|Deltaproteobacteria,2MBP9@213115|Desulfovibrionales 28221|Deltaproteobacteria M Cytidylyltransferase - - - - - - - - - - - - CTP_transf_3 k59_1026605_1 861299.J421_2949 1.09e-38 134.0 COG0799@1|root,COG0799@2|Bacteria,1ZU0S@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_1179569_1 926561.KB900617_gene1481 2.09e-17 87.0 COG0845@1|root,COG0845@2|Bacteria,1V2JZ@1239|Firmicutes,24A5A@186801|Clostridia,3WAPA@53433|Halanaerobiales 186801|Clostridia M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_D23,OEP k59_143191_1 33898.JRHJ01000075_gene2944 1.97e-46 159.0 COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria 201174|Actinobacteria E Belongs to the arginase family - - 3.5.3.17 ko:K18459 - - - - ko00000,ko01000 - - - Arginase k59_143191_2 1131814.JAFO01000001_gene3553 5.74e-31 120.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRII@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases - - 6.2.1.32 ko:K08295 ko00627,ko01120,map00627,map01120 - R00982 RC00004,RC00174 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_715723_2 1229909.NSED_09450 2.17e-36 130.0 COG0347@1|root,arCOG02305@2157|Archaea 2157|Archaea K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_97225_1 926550.CLDAP_39110 2.46e-111 336.0 COG1960@1|root,COG1960@2|Bacteria,2G6E5@200795|Chloroflexi 200795|Chloroflexi C PFAM acyl-CoA dehydrogenase domain protein - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1300304_1 521719.ATXQ01000007_gene1212 8.54e-09 56.2 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1YCU3@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_1300304_2 765911.Thivi_3008 1.79e-51 176.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1WW01@135613|Chromatiales 135613|Chromatiales J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_514470_1 1121396.KB893067_gene1540 3.73e-75 243.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,42P6S@68525|delta/epsilon subdivisions,2WIWC@28221|Deltaproteobacteria,2MI1I@213118|Desulfobacterales 28221|Deltaproteobacteria EQ PFAM Hydantoinase oxoprolinase - - - - - - - - - - - - Hydant_A_N,Hydantoinase_A k59_1449801_1 637389.Acaty_c1642 1.89e-47 160.0 COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,1RN12@1236|Gammaproteobacteria 1236|Gammaproteobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_23,HTH_29,rve k59_298585_1 247634.GPB2148_3450 4.38e-05 46.2 COG2358@1|root,COG2358@2|Bacteria,1N6K6@1224|Proteobacteria 1224|Proteobacteria S TRAP transporter solute receptor TAXI family - - - - - - - - - - - - NMT1_3 k59_298585_2 1123503.KB908056_gene1930 1.1e-33 134.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria 28211|Alphaproteobacteria T methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_243646_1 717774.Marme_2524 9.18e-48 169.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1XHGA@135619|Oceanospirillales 135619|Oceanospirillales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_243646_2 452652.KSE_21240 3.96e-06 52.4 COG0772@1|root,COG0772@2|Bacteria,2GKXP@201174|Actinobacteria,2M1K2@2063|Kitasatospora 201174|Actinobacteria D Cell cycle protein ftsW GO:0008150,GO:0040007 2.4.1.227 ko:K02563,ko:K03588 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011,ko02000,ko03036 2.A.103.1 GT28 - FTSW_RODA_SPOVE k59_401235_1 330214.NIDE0007 4.12e-58 184.0 COG0691@1|root,COG0691@2|Bacteria,3J0Q4@40117|Nitrospirae 40117|Nitrospirae O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB k59_401235_2 926566.Terro_2278 9.05e-07 50.4 COG0652@1|root,COG0652@2|Bacteria,3Y4CX@57723|Acidobacteria,2JJ67@204432|Acidobacteriia 204432|Acidobacteriia O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K03767 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_1541016_1 330214.NIDE0608 5.82e-90 273.0 COG1005@1|root,COG1005@2|Bacteria,3J0E2@40117|Nitrospirae 40117|Nitrospirae C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_925629_1 1380367.JIBC01000004_gene2217 1.92e-20 94.0 COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,2TUWC@28211|Alphaproteobacteria,3ZVCQ@60136|Sulfitobacter 28211|Alphaproteobacteria Q hydratase' hpaH - - ko:K02509 ko00350,ko01120,map00350,map01120 - R04132,R06897 RC01615,RC02595 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_1661212_1 330214.NIDE2642 1.23e-83 259.0 COG0795@1|root,COG0795@2|Bacteria,3J0S0@40117|Nitrospirae 40117|Nitrospirae S Predicted permease YjgP/YjgQ family - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_97254_1 398767.Glov_1760 1.06e-35 137.0 COG2199@1|root,COG2204@1|root,COG2204@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase mmoQ - 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,HDOD,Response_reg k59_1300343_1 670487.Ocepr_2061 2.56e-25 111.0 COG3420@1|root,COG3420@2|Bacteria,1WNFU@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P Right handed beta helix region - - - - - - - - - - - - Beta_helix,DUF11 k59_1626012_1 1123279.ATUS01000003_gene518 2.44e-53 184.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,1S1HK@1236|Gammaproteobacteria,1J81P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1155922_1 314230.DSM3645_17550 3.39e-64 216.0 COG0058@1|root,COG0058@2|Bacteria,2IY0J@203682|Planctomycetes 203682|Planctomycetes G COG0058 Glucan phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_687453_1 243365.CV_3197 3.3e-10 63.2 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2VHJ4@28216|Betaproteobacteria,2KPRN@206351|Neisseriales 206351|Neisseriales S TldD PmbA family protein pmbA - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_687453_2 765910.MARPU_00095 9.3e-57 194.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales 135613|Chromatiales L PFAM UvrD REP helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_215618_1 1188256.BASI01000005_gene2068 1.19e-30 119.0 COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP,TAT_signal k59_687458_1 330214.NIDE0595 6.65e-94 292.0 COG0322@1|root,COG0322@2|Bacteria,3J0F1@40117|Nitrospirae 40117|Nitrospirae L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N k59_1626018_1 746697.Aeqsu_2728 1.77e-39 136.0 COG3011@1|root,COG3011@2|Bacteria,4NQ93@976|Bacteroidetes,1I30U@117743|Flavobacteriia 976|Bacteroidetes S Thiol-disulfide oxidoreductase yuxK - - - - - - - - - - - DUF393 k59_1626018_2 586416.GZ22_08090 7.79e-06 47.0 COG0075@1|root,COG3916@1|root,COG0075@2|Bacteria,COG3916@2|Bacteria,1TR3I@1239|Firmicutes,4HA6W@91061|Bacilli 91061|Bacilli E Aminotransferase class-V - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_5,Acetyltransf_9,Aminotran_5 k59_1470269_1 1265505.ATUG01000001_gene4392 2.03e-46 155.0 2C477@1|root,32RDF@2|Bacteria,1RKW1@1224|Proteobacteria,42SWN@68525|delta/epsilon subdivisions,2WP88@28221|Deltaproteobacteria,2MNB4@213118|Desulfobacterales 28221|Deltaproteobacteria S DGC domain - - - - - - - - - - - - DGC k59_636301_1 195250.CM001776_gene2659 3.52e-182 522.0 COG1171@1|root,COG1171@2|Bacteria,1G22X@1117|Cyanobacteria,1GZ4N@1129|Synechococcus 1117|Cyanobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - iJN678.ilvA PALP,Thr_dehydrat_C k59_636301_2 1121935.AQXX01000143_gene4239 2.14e-19 85.1 COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,1RNF8@1236|Gammaproteobacteria,1XH9C@135619|Oceanospirillales 135619|Oceanospirillales G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A k59_1417759_1 338966.Ppro_3585 4.23e-83 259.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,42Q5K@68525|delta/epsilon subdivisions,2X5HI@28221|Deltaproteobacteria,43UF4@69541|Desulfuromonadales 28221|Deltaproteobacteria P PFAM phosphate transporter pit - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_1417759_2 1254432.SCE1572_22110 1.19e-56 185.0 COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,42SPV@68525|delta/epsilon subdivisions,2WPTH@28221|Deltaproteobacteria,2Z0HM@29|Myxococcales 28221|Deltaproteobacteria P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_792954_1 264198.Reut_A1827 1.97e-52 180.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VKM4@28216|Betaproteobacteria,1K523@119060|Burkholderiaceae 28216|Betaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_529622_2 1229909.NSED_00120 7.08e-12 64.3 COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota 651137|Thaumarchaeota H S-adenosylmethionine synthetase - - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_477406_1 665571.STHERM_c05440 7.16e-96 297.0 COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes 203691|Spirochaetes T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains rrp-2 - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_636313_1 443218.AS9A_4046 5.36e-53 187.0 COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,234Q7@1762|Mycobacteriaceae 201174|Actinobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - iNJ661.Rv3436c GATase_6,SIS k59_1626764_1 349163.Acry_2577 1.48e-91 280.0 COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2TR02@28211|Alphaproteobacteria,2JQTQ@204441|Rhodospirillales 204441|Rhodospirillales I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1626765_2 909663.KI867150_gene1577 6.36e-13 63.9 COG0828@1|root,COG0828@2|Bacteria,1MZA1@1224|Proteobacteria,42XSC@68525|delta/epsilon subdivisions,2WT18@28221|Deltaproteobacteria,2MSI8@213462|Syntrophobacterales 28221|Deltaproteobacteria J Ribosomal protein S21 rpsU GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 k59_1313131_1 641491.DND132_2364 8.34e-17 85.1 COG1808@1|root,COG1808@2|Bacteria,1NMS3@1224|Proteobacteria,42PXT@68525|delta/epsilon subdivisions,2WR2Y@28221|Deltaproteobacteria,2MAJD@213115|Desulfovibrionales 28221|Deltaproteobacteria S Domain of unknown function (DUF389) - - - - - - - - - - - - DUF389 k59_1626767_1 330214.NIDE4108 5.16e-56 176.0 COG0789@1|root,COG0789@2|Bacteria,3J0VF@40117|Nitrospirae 40117|Nitrospirae K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 k59_1573984_1 153721.MYP_4849 8.2e-31 116.0 COG0491@1|root,COG0491@2|Bacteria,4NE2Y@976|Bacteroidetes,47PA3@768503|Cytophagia 976|Bacteroidetes P PFAM Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1573984_2 596320.NEIFL0001_1715 1.66e-11 64.3 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,2KPP0@206351|Neisseriales 206351|Neisseriales H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_1313135_1 379066.GAU_2084 1.21e-64 204.0 2DBN7@1|root,2ZA2Y@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4159) - - - - - - - - - - - - DUF4159 k59_1471172_1 1122931.AUAE01000040_gene2809 3.93e-19 95.5 COG1453@1|root,COG1453@2|Bacteria,4P07C@976|Bacteroidetes,2FRKN@200643|Bacteroidia,22YVY@171551|Porphyromonadaceae 976|Bacteroidetes S Aldo/keto reductase family - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red,Fer4_17 k59_636333_1 1469245.JFBG01000019_gene1125 2.04e-39 145.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1WXI8@135613|Chromatiales 135613|Chromatiales J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_1365647_1 247490.KSU1_C1324 1.74e-16 84.0 COG1957@1|root,COG3055@1|root,COG3204@1|root,COG4932@1|root,COG1957@2|Bacteria,COG3055@2|Bacteria,COG3204@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - - ko:K02674,ko:K07004 - - - - ko00000,ko02035,ko02044 - - - DUF547,Laminin_G_3,Malectin k59_1104704_2 1123261.AXDW01000014_gene3338 3.96e-13 73.2 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,1RQYX@1236|Gammaproteobacteria,1X469@135614|Xanthomonadales 135614|Xanthomonadales P Outer membrane receptor proteins mostly Fe transport yncD - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_947086_1 1229909.NSED_02195 7.48e-90 277.0 COG0065@1|root,arCOG01698@2157|Archaea,41SYT@651137|Thaumarchaeota 651137|Thaumarchaeota E 3-isopropylmalate dehydratase, large subunit - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_61834_2 2340.JV46_16310 1.38e-75 239.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1J4X9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_947091_1 745014.OMB55_00014260 1.75e-14 75.5 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1J543@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_947091_2 1469245.JFBG01000020_gene1078 1.95e-36 136.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_268823_1 944481.JAFP01000001_gene1644 8.98e-20 93.6 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria,2M6UI@213113|Desulfurellales 28221|Deltaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - ko:K11690 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctM k59_1263130_1 398767.Glov_3003 9.38e-77 239.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,42MY6@68525|delta/epsilon subdivisions,2WMDC@28221|Deltaproteobacteria 28221|Deltaproteobacteria C alcohol dehydrogenase - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1471197_2 1353529.M899_1431 5.08e-16 79.3 COG0279@1|root,COG0279@2|Bacteria,1R8MP@1224|Proteobacteria,42TNC@68525|delta/epsilon subdivisions,2WR5G@28221|Deltaproteobacteria 28221|Deltaproteobacteria G SIS domain - - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 k59_1626797_1 396595.TK90_2031 3.96e-61 206.0 COG1075@1|root,COG1075@2|Bacteria,1R5PF@1224|Proteobacteria,1S87U@1236|Gammaproteobacteria,1WZUV@135613|Chromatiales 135613|Chromatiales S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - DUF915,LCAT,PGAP1 k59_373153_1 1249627.D779_0567 5.03e-33 129.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1WWT9@135613|Chromatiales 135613|Chromatiales O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_373153_2 1121342.AUCO01000015_gene2672 1.33e-12 67.0 COG1280@1|root,COG1280@2|Bacteria,1V4SU@1239|Firmicutes,24KYP@186801|Clostridia 186801|Clostridia E LysE type translocator - - - - - - - - - - - - LysE k59_268838_1 338963.Pcar_2412 3.24e-65 214.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,42M48@68525|delta/epsilon subdivisions,2WISV@28221|Deltaproteobacteria,43S1V@69541|Desulfuromonadales 28221|Deltaproteobacteria O C-terminal, D2-small domain, of ClpB protein hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_636388_1 1410653.JHVC01000001_gene1554 6.11e-34 130.0 COG1180@1|root,COG1180@2|Bacteria,1TP46@1239|Firmicutes,248K9@186801|Clostridia,36EV6@31979|Clostridiaceae 186801|Clostridia C Radical SAM domain protein - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_636388_2 396588.Tgr7_1521 6.88e-08 52.0 2EJUZ@1|root,33DJM@2|Bacteria,1NIYD@1224|Proteobacteria,1SGV4@1236|Gammaproteobacteria,1WZJR@135613|Chromatiales 135613|Chromatiales S Putative prokaryotic signal transducing protein - - - - - - - - - - - - DUF2007 k59_111320_1 420662.Mpe_A1836 2.47e-27 107.0 2EKAP@1|root,33E0Y@2|Bacteria,1NAAI@1224|Proteobacteria,2VZTN@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_581937_1 118163.Ple7327_0401 4.43e-28 112.0 COG1812@1|root,COG1812@2|Bacteria 2|Bacteria E S-adenosylmethionine synthetase (AdoMet synthetase) metK-2 - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_Synthase k59_581937_2 1121939.L861_18905 1.16e-63 201.0 COG1628@1|root,COG1628@2|Bacteria,1RCX1@1224|Proteobacteria,1S7VS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function DUF99 - - - ko:K09120 - - - - ko00000 - - - DUF99 k59_1574028_1 1269813.ATUL01000008_gene1501 3.24e-42 154.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales 135613|Chromatiales J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_1574028_2 323261.Noc_2119 8.54e-31 113.0 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria,1WYHM@135613|Chromatiales 135613|Chromatiales J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_1263156_2 589865.DaAHT2_1391 6.94e-42 159.0 COG1305@1|root,COG1305@2|Bacteria,1RARF@1224|Proteobacteria,42R14@68525|delta/epsilon subdivisions,2WN3R@28221|Deltaproteobacteria,2MJNR@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM transglutaminase domain protein - - - - - - - - - - - - Transglut_core k59_999177_2 298654.FraEuI1c_3387 1.21e-08 57.8 COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,4EU9D@85013|Frankiales 201174|Actinobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_162187_1 716928.AJQT01000108_gene1094 5.24e-183 561.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,4B81Q@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_1471234_1 998674.ATTE01000001_gene3863 9.92e-12 64.7 COG3541@1|root,COG3541@2|Bacteria,1R522@1224|Proteobacteria,1RZG7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Predicted nucleotidyltransferase - - - - - - - - - - - - Nuc-transf k59_1104747_1 1255043.TVNIR_3549 1.73e-47 157.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1WWXG@135613|Chromatiales 135613|Chromatiales L PFAM HNH endonuclease - - - - - - - - - - - - HNH_5 k59_1104747_2 1123401.JHYQ01000005_gene280 1.02e-10 61.6 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,463NI@72273|Thiotrichales 72273|Thiotrichales C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4_20,Fer4_7,Pyr_redox_2 k59_1263165_1 1203568.HMPREF1484_00402 5.6e-09 60.5 COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,4FCPK@85020|Dermabacteraceae 201174|Actinobacteria T Inner membrane component of T3SS, cytoplasmic domain fhaB GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - - - - - - - - - - FHA,Yop-YscD_cpl k59_425490_1 395965.Msil_2380 1.52e-06 55.5 COG3735@1|root,COG3735@2|Bacteria,1RBFT@1224|Proteobacteria,2U5YM@28211|Alphaproteobacteria,3NCEZ@45404|Beijerinckiaceae 28211|Alphaproteobacteria S TraB family - - - ko:K09973 - - - - ko00000 - - - TraB k59_947127_1 998674.ATTE01000001_gene1370 3.73e-136 397.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,460BB@72273|Thiotrichales 1236|Gammaproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine - - 1.1.1.23,1.1.1.308 ko:K00013,ko:K15509 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_1313188_2 1173264.KI913949_gene3511 1.68e-29 113.0 COG3350@1|root,COG3350@2|Bacteria,1G6RV@1117|Cyanobacteria,1HBTF@1150|Oscillatoriales 1117|Cyanobacteria S Yhs domain-containing protein - - - - - - - - - - - - YHS k59_1313188_3 1121861.KB899913_gene2284 7.45e-104 307.0 COG0834@1|root,COG0834@2|Bacteria,1N2RR@1224|Proteobacteria,2U0AF@28211|Alphaproteobacteria 28211|Alphaproteobacteria ET COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_1471247_1 696747.NIES39_Q00440 5.78e-19 88.6 COG1167@1|root,COG1167@2|Bacteria,1G425@1117|Cyanobacteria,1H8K7@1150|Oscillatoriales 1117|Cyanobacteria K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - - - - - - - - - - Aminotran_1_2,GntR k59_1263178_1 420662.Mpe_A3819 3.1e-54 182.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2VI1H@28216|Betaproteobacteria,1KN3K@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Transposase domain (DUF772) - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_843396_1 309807.SRU_1312 1.87e-72 239.0 COG1164@1|root,COG1164@2|Bacteria,4NFYH@976|Bacteroidetes,1FIWW@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Oligopeptidase F pepF - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_268868_1 316067.Geob_1502 4.07e-17 86.7 COG1629@1|root,COG4886@1|root,COG4771@2|Bacteria,COG4886@2|Bacteria 2|Bacteria S regulation of response to stimulus inlA - - ko:K02014,ko:K13730 ko05100,map05100 - - - ko00000,ko00001,ko02000 1.B.14 - - DUF285,FecR,LRR_4,Strep_his_triad,TPR_16 k59_373193_1 632518.Calow_1171 3.47e-30 115.0 COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,42EMQ@68295|Thermoanaerobacterales 186801|Clostridia E ABC transporter related livF - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_373193_2 1306406.ASHX01000001_gene3270 7.65e-10 60.1 COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria 201174|Actinobacteria E ABC transporter livG - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_793082_2 550540.Fbal_3450 6.6e-35 132.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Na Pi-Cotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans k59_268871_1 1266998.ATUJ01000011_gene2428 3.39e-31 118.0 COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,2U1PY@28211|Alphaproteobacteria,2PYD4@265|Paracoccus 28211|Alphaproteobacteria C FMN_bind nqrC - 1.6.5.8 ko:K00348 - - - - ko00000,ko01000 - - - FMN_bind k59_636440_1 504487.JCM19302_3553 2.9e-52 179.0 COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes,1HY2V@117743|Flavobacteriia 976|Bacteroidetes Q Imidazolonepropionase and related - - - - - - - - - - - - Amidohydro_1 k59_329446_2 1122599.AUGR01000015_gene2620 1.64e-11 65.9 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XHII@135619|Oceanospirillales 135619|Oceanospirillales T Diguanylate cyclase phosphodiesterase with PAS PAC - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF,PAS_9 k59_1163118_1 330214.NIDE4254 9.97e-111 330.0 COG0624@1|root,COG0624@2|Bacteria 2|Bacteria E succinyl-diaminopimelate desuccinylase activity - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_537403_1 977880.RALTA_A3016 2.81e-213 612.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2VJTS@28216|Betaproteobacteria,1K2Y9@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the 5'-nucleotidase family - - 3.1.3.5,3.6.1.45 ko:K11751,ko:K17224 ko00230,ko00240,ko00760,ko00920,ko01100,ko01110,ko01120,map00230,map00240,map00760,map00920,map01100,map01110,map01120 M00595 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R10151 RC00017,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 - - - 5_nucleotid_C k59_803794_1 443144.GM21_0286 3.29e-41 147.0 COG2159@1|root,COG2159@2|Bacteria,1R7E1@1224|Proteobacteria 1224|Proteobacteria S PFAM Amidohydrolase 2 uxuA - 4.2.1.8 ko:K01686 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_2 k59_803794_2 358220.C380_23560 1.13e-33 130.0 COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2VHZV@28216|Betaproteobacteria,4ADHI@80864|Comamonadaceae 28216|Betaproteobacteria C FMN-dependent dehydrogenase mdlB - 1.1.99.31 ko:K15054 ko00627,ko01120,map00627,map01120 - R04160,R07664 RC00240 ko00000,ko00001,ko01000 - - - FMN_dh k59_433329_1 1453501.JELR01000001_gene2316 4.96e-22 101.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1T3IM@1236|Gammaproteobacteria,465P2@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_120262_1 1504981.KO116_0273 2.43e-10 65.1 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1XJVN@135619|Oceanospirillales 135619|Oceanospirillales NU Pilus assembly protein PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_329458_1 278963.ATWD01000002_gene215 4.35e-43 152.0 COG3275@1|root,COG3275@2|Bacteria 2|Bacteria T phosphorelay sensor kinase activity lytS GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 ko:K02478,ko:K07704 ko02020,map02020 M00492 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - iECW_1372.ECW_m2327,iWFL_1372.ECW_m2327 5TM-5TMR_LYT,ECF_trnsprt,GAF_3,HATPase_c,His_kinase k59_1635605_1 404589.Anae109_1848 2.22e-63 207.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,42NRM@68525|delta/epsilon subdivisions,2WJ0S@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoH - - ko:K03086,ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1112579_1 1177154.Y5S_01865 5.01e-51 173.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RYX7@1236|Gammaproteobacteria,1XPCT@135619|Oceanospirillales 135619|Oceanospirillales L DDE domain - - - - - - - - - - - - rve k59_1112579_2 595494.Tola_1061 3.02e-14 70.9 COG2963@1|root,COG2963@2|Bacteria,1N1CG@1224|Proteobacteria,1SAIC@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_1635614_1 1123251.ATWM01000003_gene1321 8.95e-27 114.0 COG0591@1|root,COG0591@2|Bacteria,2HFJM@201174|Actinobacteria,4FH82@85021|Intrasporangiaceae 201174|Actinobacteria E Sodium:solute symporter family - - - - - - - - - - - - SSF k59_955160_1 1356852.N008_14405 7.58e-142 425.0 COG0438@1|root,COG0438@2|Bacteria,4PKQN@976|Bacteroidetes,47K56@768503|Cytophagia 976|Bacteroidetes M PFAM glycogen synthase - - 2.4.1.11 ko:K00693 ko00500,ko01100,ko04151,ko04152,ko04910,ko04922,ko04931,map00500,map01100,map04151,map04152,map04910,map04922,map04931 - R00292 RC00005 ko00000,ko00001,ko01000,ko01003 - GT3 - Glycogen_syn k59_72091_1 886293.Sinac_3913 2.22e-68 213.0 COG0500@1|root,COG2226@2|Bacteria,2J12F@203682|Planctomycetes 203682|Planctomycetes Q PFAM methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_746451_1 1131814.JAFO01000001_gene2244 1.11e-33 132.0 COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,2TU4M@28211|Alphaproteobacteria,3F2DE@335928|Xanthobacteraceae 28211|Alphaproteobacteria EGP MFS_1 like family yfkF - - - - - - - - - - - MFS_1,MFS_1_like,Sugar_tr k59_1427874_1 1232410.KI421418_gene2434 8.02e-39 140.0 COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,42NP7@68525|delta/epsilon subdivisions,2WKJU@28221|Deltaproteobacteria,43TFQ@69541|Desulfuromonadales 28221|Deltaproteobacteria O OsmC-like protein - - - ko:K06889,ko:K07397 - - - - ko00000 - - - Abhydrolase_1,Hydrolase_4,OsmC k59_1427874_2 765911.Thivi_3008 1.85e-09 58.5 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1WW01@135613|Chromatiales 135613|Chromatiales J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_487964_1 58123.JOFJ01000010_gene832 9.87e-20 89.4 COG3509@1|root,COG3509@2|Bacteria,2IDMP@201174|Actinobacteria 201174|Actinobacteria Q depolymerase - - - - - - - - - - - - - k59_1219416_1 1218352.B597_005635 7.23e-200 561.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1Z1TD@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria I COG1960 Acyl-CoA dehydrogenases - - - ko:K18244 - - - - ko00000,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1219416_2 1392838.AWNM01000035_gene284 1.51e-55 185.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VMYW@28216|Betaproteobacteria,3T3PZ@506|Alcaligenaceae 28216|Betaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_851225_1 314278.NB231_14768 7.95e-51 170.0 COG0300@1|root,COG0300@2|Bacteria,1P42K@1224|Proteobacteria,1RS9E@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_646788_1 1194972.MVAC_02464 2.53e-106 333.0 COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,233RN@1762|Mycobacteriaceae 201174|Actinobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_955176_1 880070.Cycma_1712 6.67e-27 107.0 COG3222@1|root,COG3222@2|Bacteria,4NM7F@976|Bacteroidetes,47PF2@768503|Cytophagia 976|Bacteroidetes S protein conserved in bacteria - - - ko:K09931 - - - - ko00000 - - - DUF2064 k59_955176_2 237368.SCABRO_01834 3.39e-32 125.0 COG0500@1|root,COG0535@1|root,COG0535@2|Bacteria,COG2226@2|Bacteria,2IYB6@203682|Planctomycetes 203682|Planctomycetes Q Methylase involved in ubiquinone menaquinone - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 k59_276906_1 1089552.KI911559_gene3333 1.64e-26 106.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2JPAE@204441|Rhodospirillales 204441|Rhodospirillales I Belongs to the thiolase family phbA - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_276906_2 998674.ATTE01000001_gene2474 9.62e-54 175.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,1RNH2@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) phbB - 1.1.1.100,1.1.1.36 ko:K00023,ko:K00059 ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212 M00083,M00373,M00572 R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00103,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_487980_1 266117.Rxyl_2541 3.66e-79 246.0 COG3588@1|root,COG3588@2|Bacteria,2GJ0D@201174|Actinobacteria 201174|Actinobacteria G PFAM Fructose-bisphosphate aldolase, class-I fbaB - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic k59_1373492_1 706587.Desti_5255 2.08e-72 245.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2MR5Q@213462|Syntrophobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_276907_1 1278073.MYSTI_00582 7.08e-39 148.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria 1224|Proteobacteria K PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - Sigma54_activat k59_1481548_1 330214.NIDE0834 1.02e-97 295.0 COG0045@1|root,COG0045@2|Bacteria,3J185@40117|Nitrospirae 40117|Nitrospirae H ATP citrate lyase citrate-binding - - 2.3.3.8 ko:K15231 ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200 M00173 R00352 RC00004,RC00067 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Citrate_bind k59_487984_1 1220583.GOACH_12_00120 1.14e-21 96.3 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4GFXS@85026|Gordoniaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C,PP-binding k59_487984_2 1380394.JADL01000001_gene1947 3.08e-08 55.5 COG1638@1|root,COG1638@2|Bacteria,1MWAW@1224|Proteobacteria,2TV91@28211|Alphaproteobacteria,2JRN7@204441|Rhodospirillales 204441|Rhodospirillales G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - - - - - - - - - - DctP k59_276910_1 765913.ThidrDRAFT_1731 1.06e-73 245.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_276910_2 95619.PM1_0200600 1.09e-41 152.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1219431_1 1379270.AUXF01000001_gene2139 5.98e-43 152.0 COG1228@1|root,COG1228@2|Bacteria,1ZSU7@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1007552_1 525368.HMPREF0591_1991 4.57e-11 68.2 COG1020@1|root,COG1020@2|Bacteria,2GKGU@201174|Actinobacteria,23579@1762|Mycobacteriaceae 201174|Actinobacteria I Belongs to the long-chain O-acyltransferase family - - 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - DUF1298,WES_acyltransf k59_224426_1 755731.Clo1100_1870 1.87e-63 206.0 COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,248ED@186801|Clostridia,36EJW@31979|Clostridiaceae 186801|Clostridia J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_589915_1 933262.AXAM01000004_gene2357 8.61e-68 219.0 COG2070@1|root,COG2070@2|Bacteria,1QZ4T@1224|Proteobacteria,43CFR@68525|delta/epsilon subdivisions,2X7QT@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Conserved region in glutamate synthase - - - - - - - - - - - - Glu_synthase k59_696373_1 404380.Gbem_1811 2.22e-14 76.3 COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,42M45@68525|delta/epsilon subdivisions,2WM19@28221|Deltaproteobacteria,43VQQ@69541|Desulfuromonadales 28221|Deltaproteobacteria S von Willebrand factor (vWF) type A domain batB - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,TPR_1,TPR_16,TPR_2,VWA,VWA_2 k59_487996_2 261292.Nit79A3_0578 8.33e-46 149.0 COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2VUM7@28216|Betaproteobacteria,373AT@32003|Nitrosomonadales 28216|Betaproteobacteria S YCII-related domain yciI - - ko:K09780 - - - - ko00000 - - - YCII k59_487996_3 1286106.MPL1_00557 7.77e-61 194.0 COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,1RQAB@1236|Gammaproteobacteria,460TE@72273|Thiotrichales 72273|Thiotrichales D probably involved in intracellular septation ispZ - - ko:K06190 - - - - ko00000 - - - IspA k59_955196_1 223283.PSPTO_2597 0.000213 47.8 COG1021@1|root,COG1021@2|Bacteria,1NSN8@1224|Proteobacteria,1RP8K@1236|Gammaproteobacteria,1Z6XI@136849|Pseudomonas syringae group 1236|Gammaproteobacteria Q AMP-binding enzyme C-terminal domain irp5 - 2.7.7.58,6.3.2.14 ko:K02363,ko:K04783 ko01053,ko01110,ko01130,map01053,map01110,map01130 - R07644 RC00162,RC03046 ko00000,ko00001,ko01000,ko01008 - - - AMP-binding,AMP-binding_C,Chorismate_bind k59_1220385_1 1239962.C943_00084 1.43e-27 117.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1141@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1141@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,4NF4F@976|Bacteroidetes 976|Bacteroidetes C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1636684_1 1122603.ATVI01000009_gene2612 4.08e-31 112.0 COG0724@1|root,COG0724@2|Bacteria 2|Bacteria K RNA recognition motif - - - - - - - - - - - - RRM_1 k59_1636684_2 1485544.JQKP01000003_gene122 4.94e-51 162.0 COG2920@1|root,COG2920@2|Bacteria,1RITK@1224|Proteobacteria,2W32H@28216|Betaproteobacteria,44WIY@713636|Nitrosomonadales 28216|Betaproteobacteria P DsrC like protein - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_1428893_1 1089552.KI911559_gene2079 3.75e-153 439.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria,2JQNJ@204441|Rhodospirillales 204441|Rhodospirillales E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1008366_1 570967.JMLV01000010_gene1228 8.35e-52 172.0 2ANPA@1|root,31DNS@2|Bacteria,1RHTE@1224|Proteobacteria,2U8XN@28211|Alphaproteobacteria,2JS3P@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function (DUF3833) - - - - - - - - - - - - DUF3833 k59_225209_1 1349767.GJA_3602 1.68e-30 117.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VI2K@28216|Betaproteobacteria,475QE@75682|Oxalobacteraceae 28216|Betaproteobacteria E Cys/Met metabolism PLP-dependent enzyme mdeA_1 - 2.5.1.48,2.5.1.49 ko:K01739,ko:K01740 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00999,R01287,R01288,R02508,R03217,R03260,R04859,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00420,RC02821,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_225209_2 1366050.N234_27680 1.63e-34 123.0 COG5553@1|root,COG5553@2|Bacteria,1RD6A@1224|Proteobacteria 1224|Proteobacteria S of the double-stranded beta helix - - - - - - - - - - - - CDO_I k59_647839_1 981384.AEYW01000013_gene599 6.57e-10 64.3 COG1053@1|root,COG1053@2|Bacteria,1QWW9@1224|Proteobacteria,2UQQQ@28211|Alphaproteobacteria,4N9X6@97050|Ruegeria 28211|Alphaproteobacteria C Glucose inhibited division protein A - - - - - - - - - - - - FAD_oxidored k59_1061448_1 1122172.KB890259_gene876 2.07e-10 65.5 COG0465@1|root,COG0465@2|Bacteria,378CN@32066|Fusobacteria 32066|Fusobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_1220399_1 323261.Noc_2233 1.01e-09 57.8 2EHHF@1|root,33B9C@2|Bacteria,1NM2H@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1008375_2 862908.BMS_1219 7.51e-14 77.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N1I@68525|delta/epsilon subdivisions,2MUA1@213481|Bdellovibrionales,2WNI2@28221|Deltaproteobacteria 213481|Bdellovibrionales C cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG k59_1008376_1 1198232.CYCME_0335 3.98e-102 317.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,45ZQH@72273|Thiotrichales 72273|Thiotrichales E peptidase - - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_1220406_1 1267535.KB906767_gene4838 4.65e-77 256.0 COG0457@1|root,COG3119@1|root,COG0457@2|Bacteria,COG3119@2|Bacteria 2|Bacteria P arylsulfatase activity - - - - - - - - - - - - Sulfatase,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_647860_1 1121428.DESHY_50102___1 1.25e-55 187.0 COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,26071@186807|Peptococcaceae 186801|Clostridia J tRNA synthetase class II core domain (G, H, P, S and T) hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_7534_1 1278309.KB907100_gene2212 1.59e-130 387.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,1RME6@1236|Gammaproteobacteria,1XIYC@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the formate--tetrahydrofolate ligase family fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_1220416_1 1207063.P24_11280 4.39e-95 285.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2JP9V@204441|Rhodospirillales 204441|Rhodospirillales EP Belongs to the ABC transporter superfamily oppD - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_330351_1 329726.AM1_1416 3.17e-62 213.0 COG5001@1|root,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria 1117|Cyanobacteria T Diguanylate cyclase - - - - - - - - - - - - CBS,CHASE4,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1582920_1 272562.CA_C0535 6.66e-16 81.3 COG1237@1|root,COG1237@2|Bacteria,1UWI6@1239|Firmicutes,247K3@186801|Clostridia,36H5I@31979|Clostridiaceae 186801|Clostridia S hmm pf00753 - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - Lactamase_B k59_1428929_1 1125863.JAFN01000001_gene473 3.51e-122 365.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42NH8@68525|delta/epsilon subdivisions,2WJMA@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase - - - - - - - - - - - - Bac_transf,CoA_binding_3 k59_434384_1 497964.CfE428DRAFT_3363 8.12e-50 171.0 COG0671@1|root,COG0671@2|Bacteria,46V6Y@74201|Verrucomicrobia 74201|Verrucomicrobia I PAP2 superfamily - - - - - - - - - - - - PAP2_3 k59_1636728_1 765910.MARPU_08150 2.66e-145 418.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1WXW8@135613|Chromatiales 135613|Chromatiales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_277868_1 1265313.HRUBRA_01247 8.38e-30 114.0 COG1028@1|root,COG1028@2|Bacteria,1RAEZ@1224|Proteobacteria,1S615@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) csgA - - - - - - - - - - - adh_short k59_277868_2 386456.JQKN01000007_gene3362 6.81e-07 51.6 arCOG04820@1|root,arCOG04820@2157|Archaea,2XX4W@28890|Euryarchaeota 28890|Euryarchaeota T PFAM SOUL heme-binding protein - - - - - - - - - - - - SOUL k59_1286820_1 522306.CAP2UW1_2461 5.2e-23 100.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2VKCK@28216|Betaproteobacteria,1KQVQ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Biotin-lipoyl like mdtA_2 - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_1286820_2 243233.MCA2131 1.13e-75 253.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XDW6@135618|Methylococcales 135618|Methylococcales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_861162_1 224911.27354644 1.33e-78 242.0 COG1024@1|root,COG1024@2|Bacteria,1MW41@1224|Proteobacteria,2TUR5@28211|Alphaproteobacteria,3JVAH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_131995_1 926562.Oweho_1925 2.33e-28 119.0 COG4531@1|root,COG4531@2|Bacteria,4NF0R@976|Bacteroidetes,1HY1X@117743|Flavobacteriia,2PAAV@246874|Cryomorphaceae 976|Bacteroidetes P Quinol cytochrome c oxidoreductase actF - - - - - - - - - - - - k59_1122227_2 83406.HDN1F_32770 3.56e-38 135.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1J5QQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA GO:0000217,GO:0000400,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_546739_1 1410620.SHLA_19c000380 5.88e-66 216.0 COG0160@1|root,COG0160@2|Bacteria,1MX0Y@1224|Proteobacteria,2TRAZ@28211|Alphaproteobacteria,4BM4R@82115|Rhizobiaceae 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_546739_2 1354722.JQLS01000005_gene3847 1.27e-17 84.7 COG2334@1|root,COG2334@2|Bacteria,1MXTW@1224|Proteobacteria,2U31H@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_705879_1 1236541.BALL01000011_gene1804 3.84e-58 189.0 COG3066@1|root,COG3066@2|Bacteria,1MVYX@1224|Proteobacteria,1RQVV@1236|Gammaproteobacteria,2Q933@267890|Shewanellaceae 1236|Gammaproteobacteria L Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair mutH GO:0000018,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009036,GO:0009987,GO:0015666,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0019219,GO:0019222,GO:0031323,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0043765,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1990391 - ko:K03573 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutH k59_705879_2 32049.SYNPCC7002_A0746 1.09e-15 75.9 COG0042@1|root,COG0042@2|Bacteria,1G0ME@1117|Cyanobacteria,1GZ5V@1129|Synechococcus 1117|Cyanobacteria H Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs dusA - - ko:K05539 - - - - ko00000,ko01000,ko03016 - - - Dus k59_816807_1 330214.NIDE1411 7.82e-142 413.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_233726_1 999141.GME_04587 3.13e-53 174.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,1XJIB@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_339070_1 1112274.KI911560_gene1884 7.55e-52 176.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria,2KKP8@206350|Nitrosomonadales 206350|Nitrosomonadales M MlaA lipoprotein - - - ko:K04754 - - - - ko00000 - - - MlaA k59_861197_1 330214.NIDE3077 1.51e-95 299.0 COG0556@1|root,COG0556@2|Bacteria,3J0FS@40117|Nitrospirae 40117|Nitrospirae L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1494340_1 1121033.AUCF01000020_gene656 6.63e-14 72.4 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2U787@28211|Alphaproteobacteria,2JTTK@204441|Rhodospirillales 204441|Rhodospirillales M OmpA family - - - - - - - - - - - - Gly-zipper_Omp,OmpA k59_1494340_2 511062.GU3_03365 2.49e-11 64.3 COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,1RPGF@1236|Gammaproteobacteria,1Y57E@135624|Aeromonadales 135624|Aeromonadales V MatE - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_1382389_1 187272.Mlg_1016 5.98e-102 310.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1WVVJ@135613|Chromatiales 135613|Chromatiales F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_546756_1 330214.NIDE1017 8.98e-112 330.0 COG0772@1|root,COG0772@2|Bacteria,3J0IA@40117|Nitrospirae 40117|Nitrospirae D Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_233743_1 1123368.AUIS01000003_gene1624 5.96e-14 70.9 COG1826@1|root,COG1826@2|Bacteria,1PC5G@1224|Proteobacteria,1SWZB@1236|Gammaproteobacteria,2ND5M@225057|Acidithiobacillales 225057|Acidithiobacillales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation tatB - - ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_233743_2 391615.ABSJ01000034_gene1075 1.51e-10 58.5 COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,1J788@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA GO:0002790,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009977,GO:0009987,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - ko:K03116,ko:K03425 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_756186_1 1158338.JNLJ01000005_gene1820 3.5e-31 122.0 COG0682@1|root,COG0682@2|Bacteria,2G41A@200783|Aquificae 200783|Aquificae M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_286874_2 153496.JNAB01000010_gene306 4.96e-86 281.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,2JP8R@204441|Rhodospirillales 204441|Rhodospirillales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1327039_1 1265505.ATUG01000001_gene4789 3.43e-72 223.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42PYJ@68525|delta/epsilon subdivisions,2WKHY@28221|Deltaproteobacteria,2MJ28@213118|Desulfobacterales 28221|Deltaproteobacteria V PFAM ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_500964_1 631362.Thi970DRAFT_01632 2.24e-57 188.0 COG3431@1|root,COG3431@2|Bacteria,1N6PE@1224|Proteobacteria,1T0WM@1236|Gammaproteobacteria,1X23D@135613|Chromatiales 135613|Chromatiales S PFAM Sensors of blue-light using FAD - - - - - - - - - - - - BLUF,PsiE k59_1647560_1 469383.Cwoe_3579 7.92e-23 95.1 COG0440@1|root,COG0440@2|Bacteria,2GJCH@201174|Actinobacteria,4CR86@84995|Rubrobacteria 84995|Rubrobacteria E ACT domain - - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT_5,ALS_ss_C k59_1017439_1 411684.HPDFL43_16101 1.56e-14 72.8 COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,2TWD7@28211|Alphaproteobacteria,43IRH@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C COG2871 Na -transporting NADH ubiquinone oxidoreductase, subunit NqrF nqrF - 1.6.5.8 ko:K00351,ko:K16246 ko00361,ko00362,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00623,map01100,map01120,map01220 M00548 R03560,R03608,R10042,R10043 RC00046,RC00490 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1,PepSY_TM k59_1017439_3 1122603.ATVI01000006_gene684 2.33e-10 59.3 COG0517@1|root,COG0517@2|Bacteria,1QTZR@1224|Proteobacteria,1S7SY@1236|Gammaproteobacteria,1X7U8@135614|Xanthomonadales 135614|Xanthomonadales S CBS domain - - - - - - - - - - - - CBS k59_446059_1 1031711.RSPO_c01412 5.4e-05 50.1 COG2020@1|root,COG2020@2|Bacteria,1R47K@1224|Proteobacteria,2VPZR@28216|Betaproteobacteria,1K6ZR@119060|Burkholderiaceae 28216|Betaproteobacteria O isoprenylcysteine carboxyl methyltransferase - - - - - - - - - - - - ICMT,PEMT k59_178695_1 28152.DJ57_3475 4.11e-23 100.0 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,1RNKH@1236|Gammaproteobacteria,41E8W@629|Yersinia 1236|Gammaproteobacteria S Divergent polysaccharide deacetylase yibQ - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_1018436_1 926566.Terro_0386 2.74e-16 77.8 COG1932@1|root,COG1932@2|Bacteria,3Y5U8@57723|Acidobacteria,2JMMM@204432|Acidobacteriia 204432|Acidobacteriia EH Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine - - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - - k59_1232461_1 1131266.ARWQ01000002_gene513 1.11e-62 204.0 COG2025@1|root,arCOG00448@2157|Archaea,41SZJ@651137|Thaumarchaeota 651137|Thaumarchaeota C Electron transfer flavoprotein domain - - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_1232461_2 1131266.ARWQ01000002_gene514 1.17e-94 284.0 COG2086@1|root,arCOG00446@2157|Archaea,41SX2@651137|Thaumarchaeota 651137|Thaumarchaeota C Electron transfer flavoprotein domain - - - ko:K03521 - - - - ko00000 - - - ETF k59_914787_1 1123288.SOV_5c00530 6.86e-47 172.0 COG3210@1|root,COG3210@2|Bacteria,1U3AW@1239|Firmicutes,4H2WE@909932|Negativicutes 909932|Negativicutes U domain protein - - - - - - - - - - - - Glug,Haemagg_act k59_502450_1 635013.TherJR_2711 1.16e-14 72.8 COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia,260VU@186807|Peptococcaceae 186801|Clostridia G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_502450_2 1380391.JIAS01000014_gene1953 5.48e-57 191.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2TSKQ@28211|Alphaproteobacteria,2JQRZ@204441|Rhodospirillales 204441|Rhodospirillales F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_600865_1 999141.GME_16072 0.000327 45.4 COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,1XH47@135619|Oceanospirillales 135619|Oceanospirillales IQ reductase - - - - - - - - - - - - adh_short k59_600865_2 1469245.JFBG01000102_gene1323 1.94e-25 105.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,1RNTG@1236|Gammaproteobacteria,1WXYC@135613|Chromatiales 135613|Chromatiales EGP Major Facilitator Superfamily - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_502457_1 1396418.BATQ01000147_gene3565 1.48e-06 53.9 COG1011@1|root,COG1011@2|Bacteria,46VA2@74201|Verrucomicrobia,2IUM3@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_502457_2 1223521.BBJX01000004_gene2499 1.1e-21 89.0 COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,2VI3V@28216|Betaproteobacteria,4ADSW@80864|Comamonadaceae 28216|Betaproteobacteria T low molecular weight phosphotyrosine protein phosphatase - - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_862263_1 243090.RB3103 2.25e-30 120.0 COG0587@1|root,COG0587@2|Bacteria,2IYGA@203682|Planctomycetes 203682|Planctomycetes L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1018463_1 768671.ThimaDRAFT_2975 8.12e-91 286.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1WX0K@135613|Chromatiales 135613|Chromatiales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5 k59_1071497_1 1001585.MDS_1678 1.86e-09 57.8 COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,1RRK3@1236|Gammaproteobacteria,1YG1M@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Uncharacterized ACR, COG1399 yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07040 - - - - ko00000 - - - DUF177 k59_1071497_2 105559.Nwat_1464 2.08e-25 95.5 COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,1SC9G@1236|Gammaproteobacteria,1WZ7D@135613|Chromatiales 135613|Chromatiales J Belongs to the bacterial ribosomal protein bL32 family rpmF - - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p k59_502469_1 395493.BegalDRAFT_3268 4.27e-07 50.8 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,1RQIE@1236|Gammaproteobacteria,460W6@72273|Thiotrichales 72273|Thiotrichales M Belongs to the skp family - - - ko:K06142 - - - - ko00000 - - - OmpH k59_502469_2 1268237.G114_07630 1.37e-22 99.8 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1Y42B@135624|Aeromonadales 135624|Aeromonadales M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_1649144_2 443143.GM18_3055 5.4e-33 124.0 COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,42W4B@68525|delta/epsilon subdivisions,2WP0P@28221|Deltaproteobacteria,43UMI@69541|Desulfuromonadales 28221|Deltaproteobacteria S TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - 5.4.2.6 ko:K01838 ko00500,map00500 - R02728,R11310 RC00408 ko00000,ko00001,ko01000 - - - HAD_2 k59_1593056_1 1121013.P873_13770 5.98e-11 69.3 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1RYK4@1236|Gammaproteobacteria,1X3CR@135614|Xanthomonadales 135614|Xanthomonadales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_547901_1 96561.Dole_1953 7.11e-113 357.0 COG1111@1|root,COG1205@1|root,COG1111@2|Bacteria,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,42M4R@68525|delta/epsilon subdivisions,2WK1V@28221|Deltaproteobacteria,2MI86@213118|Desulfobacterales 28221|Deltaproteobacteria L DEAD DEAH box helicase yprA - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C,RNase_H_2 k59_661329_1 1379270.AUXF01000001_gene2470 2.45e-57 188.0 COG0506@1|root,COG0506@2|Bacteria,1ZT6A@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Proline dehydrogenase - - - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh k59_1442040_1 880072.Desac_1083 2.15e-10 58.9 COG0517@1|root,COG0517@2|Bacteria,1N0EB@1224|Proteobacteria,42W96@68525|delta/epsilon subdivisions,2WRIB@28221|Deltaproteobacteria 28221|Deltaproteobacteria S CBS domain - - - ko:K04767,ko:K07168,ko:K07182 - - - - ko00000 - - - CBS k59_1442040_2 1502852.FG94_02479 3.78e-08 56.6 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4733N@75682|Oxalobacteraceae 28216|Betaproteobacteria T Sigma-54 interaction domain ntrC GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_600890_1 1229909.NSED_02720 1.19e-18 80.5 COG0454@1|root,arCOG00826@2157|Archaea,41T2E@651137|Thaumarchaeota 651137|Thaumarchaeota K Acetyltransferase (GNAT) domain - - 2.3.1.4 ko:K00621 ko00520,map00520 - R02058 RC00004,RC00166 ko00000,ko00001,ko01000 - - - Acetyltransf_1 k59_600890_2 436308.Nmar_0541 2.8e-49 163.0 COG1208@1|root,arCOG00666@2157|Archaea 2157|Archaea JM COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) - - 2.7.7.13 ko:K00966 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_1288437_1 1454004.AW11_02855 2.6e-52 180.0 COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,2VPQP@28216|Betaproteobacteria 28216|Betaproteobacteria CP Proton-conducting membrane transporter - - - - - - - - - - - - Proton_antipo_M,Proton_antipo_N k59_1288437_2 1453501.JELR01000002_gene524 1.74e-53 182.0 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,465QH@72275|Alteromonadaceae 1236|Gammaproteobacteria CP COG0651 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_1328095_1 1379698.RBG1_1C00001G0297 1.21e-140 410.0 COG4881@1|root,COG4881@2|Bacteria 2|Bacteria - - cbcU - - - - - - - - - - - NrfD k59_1123451_1 857087.Metme_2838 1.61e-47 165.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1XEDH@135618|Methylococcales 135618|Methylococcales E homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_1123451_2 555778.Hneap_1394 1.85e-16 78.2 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RQBM@1236|Gammaproteobacteria,1WWV0@135613|Chromatiales 135613|Chromatiales E aminotransferase class I and II - - - ko:K14261 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_1288443_1 1236541.BALL01000030_gene3316 8.64e-59 197.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,2Q8QH@267890|Shewanellaceae 1236|Gammaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_446147_1 760117.JN27_12510 2.25e-11 66.2 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4760P@75682|Oxalobacteraceae 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_9 k59_446147_2 870187.Thini_3428 1.19e-37 139.0 COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,460BE@72273|Thiotrichales 72273|Thiotrichales EGP major facilitator superfamily - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_340307_1 316278.SynRCC307_1399 1.82e-08 60.5 COG0469@1|root,COG0469@2|Bacteria,1G1IY@1117|Cyanobacteria,1GZ8S@1129|Synechococcus 1117|Cyanobacteria G Belongs to the pyruvate kinase family pykF GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PEP-utilizers,PK,PK_C k59_1336889_1 5762.XP_002672665.1 6.94e-11 62.4 COG0031@1|root,KOG1252@2759|Eukaryota 2759|Eukaryota E cysteine biosynthetic process from serine - - 2.5.1.47 ko:K01738,ko:K20553 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04016,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map04016 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000,ko03019 - - - PALP k59_1336889_2 743722.Sph21_4636 5.45e-11 67.0 COG1309@1|root,COG1309@2|Bacteria,4NMR8@976|Bacteroidetes,1ISZ6@117747|Sphingobacteriia 976|Bacteroidetes K Transcriptional regulator, TetR family - - - - - - - - - - - - TetR_N,WHG k59_188406_1 1245471.PCA10_48780 1.72e-14 79.7 COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,1RQ2K@1236|Gammaproteobacteria,1YDFC@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria P Outer membrane protein beta-barrel family phuR - - ko:K16087,ko:K16089 - - - - ko00000,ko02000 1.B.14.1,1.B.14.10,1.B.14.2 - - Plug,TonB_dep_Rec k59_1136613_1 234267.Acid_0496 2.04e-55 187.0 COG1999@1|root,COG1999@2|Bacteria,3Y3XH@57723|Acidobacteria 57723|Acidobacteria S signal sequence binding - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_458414_1 1452718.JBOY01000082_gene2135 1.77e-94 295.0 COG0209@1|root,COG0209@2|Bacteria,1N0E3@1224|Proteobacteria 1224|Proteobacteria F Ribonucleotide reductase, barrel domain - - 1.1.98.6,1.17.4.1 ko:K00525,ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024,R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC k59_1664578_1 439375.Oant_0595 8.61e-14 71.6 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2TTX4@28211|Alphaproteobacteria,1J1QK@118882|Brucellaceae 28211|Alphaproteobacteria K Uncharacterized ACR, COG1678 MA20_18155 - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_1244517_1 349124.Hhal_0092 7.43e-47 158.0 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,1RMW5@1236|Gammaproteobacteria,1WWXS@135613|Chromatiales 135613|Chromatiales P Plays a role in the regulation of phosphate uptake - - - ko:K02039 - - - - ko00000 - - - PhoU k59_1393224_1 1123368.AUIS01000021_gene990 1.5e-08 57.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,2NCVX@225057|Acidithiobacillales 225057|Acidithiobacillales J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_1393224_2 765914.ThisiDRAFT_0776 7.76e-63 201.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1WX04@135613|Chromatiales 135613|Chromatiales D PFAM Cobyrinic acid a,c-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1393225_1 913325.N799_00225 5.98e-48 162.0 COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,1RNKT@1236|Gammaproteobacteria,1X4DF@135614|Xanthomonadales 135614|Xanthomonadales F Belongs to the cytidylate kinase family. Type 1 subfamily cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin k59_1511277_2 392499.Swit_1848 1.14e-24 100.0 COG0346@1|root,COG0346@2|Bacteria,1RA53@1224|Proteobacteria,2UPCZ@28211|Alphaproteobacteria,2KD4M@204457|Sphingomonadales 204457|Sphingomonadales E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - 1.13.11.25 ko:K16049 ko00984,ko01100,ko01120,ko01220,map00984,map01100,map01120,map01220 - R04597 RC01610 ko00000,ko00001,ko01000 - - - Glyoxalase k59_718142_1 1267534.KB906755_gene4517 9.74e-09 55.8 COG1228@1|root,COG1228@2|Bacteria,3Y3PQ@57723|Acidobacteria,2JMH5@204432|Acidobacteriia 204432|Acidobacteriia Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_718142_2 1123278.KB893565_gene3538 3.66e-20 92.8 COG2866@1|root,COG2866@2|Bacteria,4NF3D@976|Bacteroidetes,47UEQ@768503|Cytophagia 976|Bacteroidetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_246122_1 944435.AXAJ01000016_gene2533 1.61e-32 128.0 COG2079@1|root,COG2079@2|Bacteria,1R5CE@1224|Proteobacteria,2W6SC@28216|Betaproteobacteria,1KCHM@119060|Burkholderiaceae 28216|Betaproteobacteria S MmgE/PrpD family - - - - - - - - - - - - MmgE_PrpD k59_1337831_2 330214.NIDE2728 3.6e-29 106.0 COG0509@1|root,COG0509@2|Bacteria,3J0SD@40117|Nitrospirae 40117|Nitrospirae E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H k59_1664611_1 1191523.MROS_0856 2.03e-68 211.0 COG2606@1|root,COG2606@2|Bacteria 2|Bacteria S Cys-tRNA(Pro) hydrolase activity - - - ko:K03976,ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_833909_1 1379270.AUXF01000003_gene3847 8.38e-10 57.4 COG0848@1|root,COG0848@2|Bacteria,1ZTXP@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Biopolymer transport protein ExbD/TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_833909_2 861299.J421_3616 1.05e-37 132.0 COG0848@1|root,COG0848@2|Bacteria,1ZTTP@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Biopolymer transport protein ExbD/TolR - - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_17754_1 1502851.FG93_03217 1.35e-48 169.0 COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2TWR2@28211|Alphaproteobacteria,3JVDD@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_767607_1 1116232.AHBF01000035_gene5542 9.61e-16 82.8 COG2267@1|root,COG2267@2|Bacteria 2|Bacteria I carboxylic ester hydrolase activity bioH - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_403550_1 1453496.AT03_09750 0.000397 39.7 COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,1SCJS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 k59_403550_2 1122194.AUHU01000018_gene3454 4.89e-49 174.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,4648S@72275|Alteromonadaceae 1236|Gammaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0010033,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0031249,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035966,GO:0036094,GO:0042221,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_718152_1 1380394.JADL01000002_gene1627 1.1e-20 93.6 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,2JQ4K@204441|Rhodospirillales 204441|Rhodospirillales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_403551_1 1049564.TevJSym_ag00070 1.56e-58 191.0 COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1J7JW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Cytochrome C1 family petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C1 k59_610526_1 1415779.JOMH01000001_gene294 1.45e-14 71.6 COG2363@1|root,COG2363@2|Bacteria,1MZX3@1224|Proteobacteria,1SCNB@1236|Gammaproteobacteria,1X8HZ@135614|Xanthomonadales 135614|Xanthomonadales S small membrane protein - - - - - - - - - - - - DUF423 k59_610526_3 1124983.PFLCHA0_c61470 4.58e-09 58.2 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria,1YMB5@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol clsA GO:0003674,GO:0003824,GO:0008808,GO:0016740,GO:0016772,GO:0016780,GO:0030572 - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_1244547_1 318424.EU78_14055 2.08e-16 79.7 COG0778@1|root,COG0778@2|Bacteria,2GM9M@201174|Actinobacteria,235BZ@1762|Mycobacteriaceae 201174|Actinobacteria C nitroreductase - - - - - - - - - - - - Nitroreductase k59_1244547_2 111781.Lepto7376_1531 6.42e-13 68.9 COG0464@1|root,COG0464@2|Bacteria,1G2M7@1117|Cyanobacteria,1HE1K@1150|Oscillatoriales 1117|Cyanobacteria O PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_1543364_1 675635.Psed_2642 1.55e-44 159.0 COG3552@1|root,COG3552@2|Bacteria,2IGRI@201174|Actinobacteria,4E91Q@85010|Pseudonocardiales 201174|Actinobacteria S VWA domain containing CoxE-like protein - - - ko:K07161 - - - - ko00000 - - - VWA_CoxE k59_1244556_1 1163617.SCD_n01466 2.24e-19 92.4 COG0745@1|root,COG3829@1|root,COG5000@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3829@2|Bacteria,COG5000@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2VP0K@28216|Betaproteobacteria 28216|Betaproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS,Response_reg k59_1451784_1 1322246.BN4_12655 8.51e-83 263.0 COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria,2MA96@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM Glycosyl transferase, family 20 otsAB - 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,S6PP,Trehalose_PPase k59_403568_2 436308.Nmar_0275 9.99e-74 224.0 COG1225@1|root,arCOG00310@2157|Archaea,41SKG@651137|Thaumarchaeota 651137|Thaumarchaeota O Redoxin - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_188466_1 1298593.TOL_0315 5.73e-10 61.2 COG1416@1|root,COG1416@2|Bacteria,1NAV2@1224|Proteobacteria,1SYA3@1236|Gammaproteobacteria,1XM9S@135619|Oceanospirillales 135619|Oceanospirillales - - - - - ko:K09004 - - - - ko00000 - - - DrsE k59_610551_1 1463926.JOCA01000010_gene2224 1.15e-19 93.2 COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria 201174|Actinobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_1511341_1 484022.Fphi_0226 1.4e-53 183.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,45ZUG@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_1337866_1 472759.Nhal_2270 4.03e-92 279.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1WWPW@135613|Chromatiales 135613|Chromatiales E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_1244574_1 1266908.AQPB01000050_gene1830 1.27e-13 74.7 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria,1WX4U@135613|Chromatiales 135613|Chromatiales T PFAM Metal-dependent phosphohydrolase, HD - - - - - - - - - - - - DUF3391,HD_5 k59_1393283_1 438753.AZC_4225 5.34e-78 251.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,3EXZB@335928|Xanthobacteraceae 28211|Alphaproteobacteria C FAD linked oxidases, C-terminal domain - - 1.1.2.4 ko:K00102 ko00620,map00620 - R00197 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_718210_1 349521.HCH_01349 3.93e-27 109.0 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,1RNKH@1236|Gammaproteobacteria,1XJSY@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_833997_1 330214.NIDE1861 4.07e-41 142.0 COG5424@1|root,COG5424@2|Bacteria 2|Bacteria H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ - - 1.3.3.11 ko:K06137 - - - - ko00000,ko01000 - - - Haem_oxygenas_2 k59_833997_2 330214.NIDE1862 8.45e-41 135.0 2CC8H@1|root,330SM@2|Bacteria,3J1D6@40117|Nitrospirae 40117|Nitrospirae - - - - - - - - - - - - - - - k59_928176_1 1379858.N508_01126 2.92e-49 177.0 COG0860@1|root,COG0860@2|Bacteria,2GF39@200930|Deferribacteres 200930|Deferribacteres M Ami_3 - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3 k59_301134_1 1122201.AUAZ01000010_gene2600 3.29e-07 51.2 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,464C7@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0530 Ca2 Na antiporter Z012_08255 - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_301134_2 1121013.P873_02690 2.02e-18 79.0 COG5007@1|root,COG5007@2|Bacteria,1R3MK@1224|Proteobacteria,1SE4M@1236|Gammaproteobacteria,1X7EE@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the BolA IbaG family SN15_13775 - - - - - - - - - - - BolA k59_1244592_1 1192034.CAP_3578 2.83e-109 337.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,4347Y@68525|delta/epsilon subdivisions,2X9D5@28221|Deltaproteobacteria,2Z1DR@29|Myxococcales 28221|Deltaproteobacteria C Aldehyde ferredoxin oxidoreductase, N-terminal domain - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_1244592_2 926569.ANT_29920 9.33e-19 88.6 COG3383@1|root,COG3383@2|Bacteria,2GBH3@200795|Chloroflexi 200795|Chloroflexi C Molybdopterin oxidoreductase Fe4S4 domain - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_872729_1 357808.RoseRS_3811 1.49e-61 200.0 COG2518@1|root,COG2518@2|Bacteria,2G6NG@200795|Chloroflexi,377B2@32061|Chloroflexia 32061|Chloroflexia J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_1511390_1 1123401.JHYQ01000024_gene1262 3.78e-59 196.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1T20Y@1236|Gammaproteobacteria,463WE@72273|Thiotrichales 72273|Thiotrichales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrB - - - - - - - - - - - NQR2_RnfD_RnfE k59_1511393_2 588581.Cpap_3474 1.52e-50 171.0 COG0310@1|root,COG0310@2|Bacteria,1TPEN@1239|Firmicutes,248S9@186801|Clostridia,3WHIW@541000|Ruminococcaceae 186801|Clostridia P PFAM cobalamin (vitamin B12) biosynthesis CbiM protein - - - ko:K02007 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiM,PDGLE k59_1393296_1 1449353.JQMQ01000005_gene1864 1.86e-17 88.2 COG1361@1|root,COG4257@1|root,COG1361@2|Bacteria,COG4257@2|Bacteria,2HERV@201174|Actinobacteria,2NKXW@228398|Streptacidiphilus 201174|Actinobacteria M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11 k59_1602471_2 391625.PPSIR1_20339 1.41e-31 123.0 COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,42S4P@68525|delta/epsilon subdivisions,2WNK7@28221|Deltaproteobacteria,2YVAH@29|Myxococcales 28221|Deltaproteobacteria V MatE norM - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_301144_1 243090.RB3174 1e-41 151.0 COG1187@1|root,COG1187@2|Bacteria,2IYUS@203682|Planctomycetes 203682|Planctomycetes J Belongs to the pseudouridine synthase RsuA family - - 5.4.99.20,5.4.99.22 ko:K06178,ko:K06181 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_676890_1 1525715.IX54_03475 3.32e-16 78.2 COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,2PW79@265|Paracoccus 28211|Alphaproteobacteria I functions in conversion of succinate to propionate bhbA - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase k59_676890_2 383372.Rcas_3873 4.06e-87 268.0 COG1703@1|root,COG1703@2|Bacteria,2G670@200795|Chloroflexi,376Q6@32061|Chloroflexia 32061|Chloroflexia E TIGRFAM LAO AO transport system ATPase - - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k59_1664749_2 444860.E3SJ00_9CAUD 1.47e-09 56.2 4QAND@10239|Viruses,4QVPE@35237|dsDNA viruses no RNA stage,4QPBN@28883|Caudovirales,4QI03@10662|Myoviridae 10662|Myoviridae S Terminase DNA packaging enzyme - GO:0005575,GO:0032991,GO:0043493 - - - - - - - - - - - k59_1029184_1 298653.Franean1_1190 1.15e-11 67.0 COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4ERHK@85013|Frankiales 201174|Actinobacteria S Belongs to the peptidase M16 family pepR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_246224_2 436308.Nmar_0843 1.01e-93 278.0 COG1208@1|root,arCOG00663@2157|Archaea,41SIU@651137|Thaumarchaeota 651137|Thaumarchaeota M Nucleotidyl transferase - - - - - - - - - - - - NTP_transferase k59_99850_1 272563.CD630_35750 1.43e-43 165.0 COG0591@1|root,COG0591@2|Bacteria,1V0NB@1239|Firmicutes,24ENM@186801|Clostridia 186801|Clostridia E Sodium:solute symporter family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_17798_1 682795.AciX8_1195 2.54e-75 241.0 COG0606@1|root,COG0606@2|Bacteria,3Y3JA@57723|Acidobacteria,2JI3F@204432|Acidobacteriia 204432|Acidobacteriia O PFAM Magnesium chelatase, ChlI subunit - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_559177_2 153721.MYP_2830 5.85e-08 54.3 COG0596@1|root,COG0596@2|Bacteria,4NJSG@976|Bacteroidetes,47XXP@768503|Cytophagia 976|Bacteroidetes S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 k59_767718_1 1394178.AWOO02000005_gene3692 1.6e-32 122.0 COG0183@1|root,COG0183@2|Bacteria,2GNCM@201174|Actinobacteria,4EGCV@85012|Streptosporangiales 201174|Actinobacteria I lipid-transfer protein - - - - - - - - - - - - Thiolase_C k59_767718_2 1121272.KB903292_gene3981 3.96e-22 94.4 COG1545@1|root,COG1545@2|Bacteria,2GJHW@201174|Actinobacteria,4DC0G@85008|Micromonosporales 201174|Actinobacteria S DUF35 OB-fold domain, acyl-CoA-associated - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_1305195_1 120017.I2FSP3 6.95e-17 86.3 COG2801@1|root,KOG0017@2759|Eukaryota,38DPC@33154|Opisthokonta,3NUZ7@4751|Fungi,3UY7N@5204|Basidiomycota 4751|Fungi L Encoded by - - - - - - - - - - - - RVT_2,Retrotran_gag_2,gag_pre-integrs,rve k59_1563561_1 1293054.HSACCH_00771 2.77e-64 214.0 COG0388@1|root,COG0388@2|Bacteria,1TQR9@1239|Firmicutes,24BFR@186801|Clostridia 186801|Clostridia S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.5.1 ko:K01501 ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120 - R00540,R01887,R03093,R03542,R05591,R07855 RC00315,RC00325,RC00617,RC00959,RC02811 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_1043978_1 754436.JCM19237_3345 2.53e-38 138.0 COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,1XSYN@135623|Vibrionales 135623|Vibrionales J With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P epmA GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 - ko:K04568 - - - - ko00000,ko01000,ko03012 - - - tRNA-synt_2 k59_1563618_1 444860.E3SIZ9_9CAUD 3.53e-103 307.0 4QASK@10239|Viruses,4QVVS@35237|dsDNA viruses no RNA stage,4QQFF@28883|Caudovirales,4QIHH@10662|Myoviridae 10662|Myoviridae S Pfam:T4-gp15_tss - GO:0005575,GO:0019012 - - - - - - - - - - - k59_1563618_2 1589733.A0A0C5AIR9_9CAUD 5.04e-25 98.2 4QAND@10239|Viruses,4QPBN@28883|Caudovirales,4QI03@10662|Myoviridae 10662|Myoviridae S Terminase DNA packaging enzyme - GO:0005575,GO:0032991,GO:0043493 - - - - - - - - - - - k59_1614809_1 1049564.TevJSym_aw00060 7.94e-06 50.4 28KIA@1|root,2ZA3I@2|Bacteria,1MXIF@1224|Proteobacteria,1RMA6@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - dsrS - - - - - - - - - - - - k59_1614809_2 948106.AWZT01000020_gene4110 2.43e-29 106.0 COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2VU2J@28216|Betaproteobacteria,1K8MR@119060|Burkholderiaceae 28216|Betaproteobacteria O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins grxC - - ko:K03676 - - - - ko00000,ko03110 - - - Glutaredoxin k59_1614809_3 1278307.KB907028_gene433 2.84e-08 54.3 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,2QHTU@267894|Psychromonadaceae 1236|Gammaproteobacteria H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302,ko:K02303,ko:K02304 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_1355026_1 330214.NIDE0211 1.94e-91 276.0 COG3496@1|root,COG3496@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1365) - - 2.1.1.79 ko:K00574,ko:K09701 - - - - ko00000,ko01000 - - - DUF1365 k59_1044045_1 439292.Bsel_3258 4.24e-40 152.0 COG0457@1|root,COG0457@2|Bacteria,1TSH7@1239|Firmicutes,4HACN@91061|Bacilli 91061|Bacilli M Tetratricopeptide repeat - - - - - - - - - - - - - k59_782351_1 439235.Dalk_5107 4.21e-69 229.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,2MIKW@213118|Desulfobacterales 28221|Deltaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1614828_1 765912.Thimo_1228 1.28e-51 183.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWB8@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1614857_1 1304875.JAFZ01000001_gene1341 0.000761 47.8 COG1181@1|root,COG1181@2|Bacteria,3TASI@508458|Synergistetes 508458|Synergistetes F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_1044129_1 123214.PERMA_1601 7.37e-30 122.0 COG2265@1|root,COG2265@2|Bacteria,2G3V7@200783|Aquificae 200783|Aquificae J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - tRNA_U5-meth_tr k59_1355108_1 1266914.ATUK01000003_gene1025 3.92e-82 247.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1WXF4@135613|Chromatiales 135613|Chromatiales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_1044149_1 1207063.P24_00225 2.91e-116 346.0 COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2TSUA@28211|Alphaproteobacteria,2JRF8@204441|Rhodospirillales 204441|Rhodospirillales E Beta-eliminating lyase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_887735_1 1235457.C404_21090 1.5e-19 81.6 COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2VR2M@28216|Betaproteobacteria,1K791@119060|Burkholderiaceae 28216|Betaproteobacteria C Required for insertion of 4Fe-4S clusters erpA - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_887735_2 397945.Aave_4050 1.51e-26 101.0 COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2VTZQ@28216|Betaproteobacteria,4AEHA@80864|Comamonadaceae 28216|Betaproteobacteria M Integral membrane protein CcmA involved in cell shape determination ccmA - - - - - - - - - - - Bactofilin k59_24951_2 471857.Svir_15320 4.16e-07 52.0 COG1052@1|root,COG1052@2|Bacteria,2I2IC@201174|Actinobacteria,4E09H@85010|Pseudonocardiales 201174|Actinobacteria CH D-isomer specific 2-hydroxyacid dehydrogenase serA2 - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_1199182_1 765913.ThidrDRAFT_3335 1.14e-40 143.0 COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,1RRS1@1236|Gammaproteobacteria,1WW2T@135613|Chromatiales 135613|Chromatiales G TIGRFAM HAD-superfamily subfamily IIA hydrolase like protein - - - - - - - - - - - - Hydrolase_6,Hydrolase_like k59_1044163_1 240292.Ava_4094 7.81e-186 527.0 COG1473@1|root,COG1473@2|Bacteria,1G01G@1117|Cyanobacteria 1117|Cyanobacteria S PFAM Peptidase family M20 M25 M40 - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_1044163_2 1283300.ATXB01000001_gene722 9.32e-109 326.0 COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,1RRZ1@1236|Gammaproteobacteria 1236|Gammaproteobacteria H ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity ybdK GO:0003674,GO:0003824,GO:0016874,GO:0016879 - ko:K06048 - - - - ko00000,ko01000 - - - GCS2 k59_1563883_2 1541960.KQ78_01067 2.36e-21 90.1 COG0698@1|root,COG0698@2|Bacteria,3WTG9@544448|Tenericutes 544448|Tenericutes G Ribose 5-phosphate isomerase rpiB - 5.3.1.26,5.3.1.6 ko:K01808,ko:K01819 ko00030,ko00051,ko00052,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00052,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R03240,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_1563884_1 1163617.SCD_n02239 1.29e-125 382.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria 28216|Betaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_887774_2 1249627.D779_1782 1.81e-21 91.3 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,1WWA0@135613|Chromatiales 135613|Chromatiales U PFAM MotA TolQ ExbB proton channel - - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_887869_1 379066.GAU_0600 7.59e-71 228.0 COG0277@1|root,COG0277@2|Bacteria,1ZT11@142182|Gemmatimonadetes 142182|Gemmatimonadetes C FAD linked oxidases, C-terminal domain - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1044291_1 1229909.NSED_06400 2.94e-18 89.7 COG3794@1|root,arCOG08764@1|root,arCOG02926@2157|Archaea,arCOG08764@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind k59_1199331_1 1121943.KB899996_gene539 3.29e-94 291.0 COG0439@1|root,COG0439@2|Bacteria,1QXYJ@1224|Proteobacteria,1T4PS@1236|Gammaproteobacteria 1236|Gammaproteobacteria I ATP-grasp domain - - - - - - - - - - - - ATP-grasp_4 k59_1199333_2 330214.NIDE0255 3.85e-40 141.0 COG1826@1|root,COG1826@2|Bacteria 2|Bacteria U protein secretion tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_887941_1 1123355.JHYO01000011_gene1471 7.91e-13 64.7 2DTP4@1|root,33M54@2|Bacteria 2|Bacteria S Domain of unknown function (DUF1127) - - - - - - - - - - - - DUF1127 k59_887941_2 756067.MicvaDRAFT_1478 1.14e-24 102.0 COG0350@1|root,COG2207@1|root,COG0350@2|Bacteria,COG2207@2|Bacteria,1G3BJ@1117|Cyanobacteria,1H9DG@1150|Oscillatoriales 1117|Cyanobacteria L TIGRFAM Methylated-DNA- protein -cysteine S-methyltransferase, DNA binding - - 2.1.1.63 ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N k59_1564158_1 391008.Smal_2613 7.05e-14 75.5 COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,1X5ZT@135614|Xanthomonadales 135614|Xanthomonadales EGP Nucleoside H+ symporter - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like k59_1199372_1 926560.KE387025_gene4050 2.41e-18 81.3 COG1796@1|root,COG1796@2|Bacteria 2|Bacteria L DNA-directed DNA polymerase activity dpbF - 3.1.11.5 ko:K02347,ko:K03581,ko:K04477 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,HHH_8 k59_1199372_2 765869.BDW_10965 1.33e-28 115.0 COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,4308T@68525|delta/epsilon subdivisions,2MTI3@213481|Bdellovibrionales,2X727@28221|Deltaproteobacteria 213481|Bdellovibrionales V membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K02003,ko:K05685 ko02010,map02010 M00258,M00709 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.122.1,3.A.1.122.12 - - ABC_tran,FtsX,MacB_PCD k59_42514_2 1209072.ALBT01000067_gene112 2.8e-17 88.6 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1FFVM@10|Cellvibrio 1236|Gammaproteobacteria G MFS/sugar transport protein ynaJ - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_42917_1 582402.Hbal_1696 7.3e-17 85.5 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TRWB@28211|Alphaproteobacteria,43WQ8@69657|Hyphomonadaceae 28211|Alphaproteobacteria E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 2.6.1.85,4.1.3.27 ko:K01657,ko:K01665 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_42955_2 518766.Rmar_0925 2.48e-19 90.9 COG1472@1|root,COG1680@1|root,COG1472@2|Bacteria,COG1680@2|Bacteria,4NET8@976|Bacteroidetes,1FJ9E@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G Glycosyl hydrolase family 3 N terminal domain - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Beta-lactamase,Glyco_hydro_3,Glyco_hydro_3_C k59_43062_1 1249627.D779_1571 5.39e-43 142.0 2CDMX@1|root,32S1K@2|Bacteria,1N1I8@1224|Proteobacteria,1S9N4@1236|Gammaproteobacteria,1WYR4@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_43127_1 706587.Desti_3153 0.000126 49.7 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42Z6U@68525|delta/epsilon subdivisions,2WU9K@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Domain of unknown function (DUF4070) - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_43194_1 675635.Psed_4788 3.1e-78 249.0 COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4E05Y@85010|Pseudonocardiales 201174|Actinobacteria C Glycolate oxidase subunit GlcD glcD - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_43613_2 502025.Hoch_4153 2.98e-28 114.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YUJ9@29|Myxococcales 28221|Deltaproteobacteria T Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_43631_1 272624.lpg0640 2.77e-05 44.7 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1JDWB@118969|Legionellales 118969|Legionellales O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_43813_1 665571.STHERM_c02160 8.66e-27 106.0 COG1701@1|root,COG1701@2|Bacteria 2|Bacteria S ligase activity - - 6.3.2.36 ko:K09722 ko00410,ko00770,ko01100,map00410,map00770,map01100 - R09379 RC00096,RC00141 ko00000,ko00001,ko01000 - - - PPS_PS k59_44072_1 655815.ZPR_2017 4.7e-42 155.0 COG0668@1|root,COG0668@2|Bacteria,4NHU7@976|Bacteroidetes,1I0RF@117743|Flavobacteriia 976|Bacteroidetes M Mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_44081_2 1408164.MOLA814_00961 2.86e-18 82.4 COG1416@1|root,COG1416@2|Bacteria,1N0U1@1224|Proteobacteria 1224|Proteobacteria S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE k59_44193_1 46234.ANA_C11617 6.99e-20 93.2 COG2831@1|root,COG2831@2|Bacteria,1G03B@1117|Cyanobacteria,1HM2B@1161|Nostocales 1117|Cyanobacteria U Hemolysin activation secretion protein - - - - - - - - - - - - POTRA_2,ShlB k59_44228_1 713586.KB900536_gene1765 9.5e-77 241.0 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,1WX0B@135613|Chromatiales 135613|Chromatiales O heat shock protein DnaJ - - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_44252_1 1313172.YM304_41440 3.81e-57 192.0 COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4CNYR@84992|Acidimicrobiia 84992|Acidimicrobiia S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_44560_1 187272.Mlg_2624 1.31e-25 109.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_8 k59_44560_2 768671.ThimaDRAFT_2365 7.94e-12 65.1 29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,1SBT1@1236|Gammaproteobacteria,1WYAZ@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4390) - - - - - - - - - - - - DUF4390 k59_44587_1 1454004.AW11_03658 5.59e-28 106.0 COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,2VSI6@28216|Betaproteobacteria,1KQ2S@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_44587_2 1131553.JIBI01000002_gene1762 7.75e-55 176.0 COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,2VQGE@28216|Betaproteobacteria,372ZT@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH - 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k59_44682_1 330214.NIDE2604 3.14e-53 176.0 28PW7@1|root,32EDN@2|Bacteria 2|Bacteria S Protein of unknown function (DUF3313) - - - - - - - - - - - - DUF3313 k59_44858_1 330084.JNYZ01000003_gene2102 9.66e-61 201.0 COG1788@1|root,COG2057@1|root,COG1788@2|Bacteria,COG2057@2|Bacteria,2GKV9@201174|Actinobacteria,4E8N2@85010|Pseudonocardiales 201174|Actinobacteria I Coenzyme A transferase pcaJ - 2.8.3.5 ko:K01027,ko:K01029 ko00072,ko00280,ko00650,map00072,map00280,map00650 - R00410 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_45024_1 765911.Thivi_1932 1.55e-57 196.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1WWSK@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB k59_45143_1 1262915.BN574_00997 3.39e-12 68.2 COG0110@1|root,COG0110@2|Bacteria,1VHA7@1239|Firmicutes 1239|Firmicutes M Hexapeptide repeat of succinyl-transferase - - 2.3.1.79 ko:K00661 - - - - ko00000,ko01000 - - - Hexapep,Hexapep_2 k59_45299_1 243233.MCA0130 5.37e-05 43.5 2EGIJ@1|root,33AAQ@2|Bacteria,1NH9B@1224|Proteobacteria,1SGKJ@1236|Gammaproteobacteria,1XFSX@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF2909) - - - - - - - - - - - - DUF2909 k59_45299_2 1255043.TVNIR_3023 1.72e-51 171.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1WX89@135613|Chromatiales 135613|Chromatiales C PFAM cytochrome c oxidase, subunit III - - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_60184_1 225117.XP_009350072.1 2.51e-60 196.0 COG0090@1|root,COG0185@1|root,KOG0438@2759|Eukaryota,KOG0899@2759|Eukaryota,37QJY@33090|Viridiplantae,3G9KA@35493|Streptophyta 35493|Streptophyta J Ribosomal protein L2 rpl2 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0031967,GO:0031975,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L23,Ribosomal_L2_C k59_946047_1 292414.TM1040_0021 1.79e-19 86.7 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2U7B0@28211|Alphaproteobacteria,4NBYC@97050|Ruegeria 28211|Alphaproteobacteria GT Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 ptsN - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_1312038_1 436308.Nmar_1788 2.23e-58 181.0 arCOG08809@1|root,arCOG08809@2157|Archaea,41TAB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1312038_2 1229909.NSED_09580 3.62e-89 266.0 COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota 651137|Thaumarchaeota L protein conserved in archaea - - - ko:K09723 - - - - ko00000,ko03032 - - - - k59_686875_2 1042375.AFPL01000046_gene1783 9.57e-64 207.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,464A5@72275|Alteromonadaceae 1236|Gammaproteobacteria G COG1593 TRAP-type C4-dicarboxylate transport system, large permease component dctM - - - - - - - - - - - DctM k59_946050_1 756272.Plabr_2876 3.57e-89 269.0 COG0388@1|root,COG0388@2|Bacteria,2IX91@203682|Planctomycetes 203682|Planctomycetes S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_791340_1 1097668.BYI23_C007810 5.79e-55 190.0 COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2VM0Y@28216|Betaproteobacteria,1K5UQ@119060|Burkholderiaceae 28216|Betaproteobacteria J PFAM Amidase - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_791340_2 1205680.CAKO01000002_gene2953 2.34e-50 170.0 COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,2U84Q@28211|Alphaproteobacteria,2JZR9@204441|Rhodospirillales 204441|Rhodospirillales P Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides - - - ko:K07232 - - - - ko00000 - - - ChaC k59_791340_3 1382303.JPOM01000001_gene1916 3.01e-58 186.0 COG0066@1|root,COG0066@2|Bacteria,1RBRQ@1224|Proteobacteria,2UA0M@28211|Alphaproteobacteria,2KIUN@204458|Caulobacterales 204458|Caulobacterales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_476325_1 765911.Thivi_3038 4.68e-154 442.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1WX3A@135613|Chromatiales 135613|Chromatiales D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_894558_1 485915.Dret_0505 4.27e-102 305.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WKXU@28221|Deltaproteobacteria,2M80I@213115|Desulfovibrionales 28221|Deltaproteobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_1209490_1 1123487.KB892857_gene2536 2.57e-36 142.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,2KUMN@206389|Rhodocyclales 206389|Rhodocyclales L DNA topoisomerase III - - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim,Toprim_Crpt k59_528496_1 981369.JQMJ01000004_gene3844 1.48e-60 204.0 COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria,2NF9U@228398|Streptacidiphilus 201174|Actinobacteria Q NAD(P)-binding Rossmann-like domain - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_267606_3 278957.ABEA03000095_gene4586 1.72e-49 168.0 COG2095@1|root,COG2095@2|Bacteria,46W2N@74201|Verrucomicrobia,3K825@414999|Opitutae 414999|Opitutae U MarC family integral membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_1572991_1 1123392.AQWL01000009_gene1028 1.14e-14 75.9 COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,2VPWB@28216|Betaproteobacteria,1KSZT@119069|Hydrogenophilales 119069|Hydrogenophilales C 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - - Fer2 k59_843110_2 268746.Q58MM2_BPPRM 2.74e-11 60.1 4QFE1@10239|Viruses,4QVB0@35237|dsDNA viruses no RNA stage,4QT55@28883|Caudovirales,4QK8A@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_843110_4 268746.Q58MM1_BPPRM 8.48e-10 57.8 4QAWI@10239|Viruses,4QW40@35237|dsDNA viruses no RNA stage,4QPUX@28883|Caudovirales,4QINW@10662|Myoviridae 10662|Myoviridae S Pfam:Peptidase_S77 - - - - - - - - - - - - - k59_688044_1 1282876.BAOK01000002_gene267 1.85e-45 157.0 COG0730@1|root,COG0730@2|Bacteria,1RDKW@1224|Proteobacteria,2TQP3@28211|Alphaproteobacteria,4BTCQ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Sulfite exporter TauE/SafE MA20_05290 - - - - - - - - - - - TauE k59_61465_3 1122621.ATZA01000024_gene2194 0.000852 42.4 COG1528@1|root,COG1528@2|Bacteria,4NGS7@976|Bacteroidetes,1IRZ5@117747|Sphingobacteriia 976|Bacteroidetes P Iron-storage protein ftnA - 1.16.3.2 ko:K02217 - - - - ko00000,ko01000 - - - Ferritin k59_61471_1 1121405.dsmv_2908 8.43e-52 183.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42MZJ@68525|delta/epsilon subdivisions,2WJK1@28221|Deltaproteobacteria,2MIBC@213118|Desulfobacterales 28221|Deltaproteobacteria C Aldehyde ferredoxin oxidoreductase - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_3723_1 1116232.AHBF01000133_gene2009 6.45e-12 65.5 COG1309@1|root,COG1309@2|Bacteria,2GNJZ@201174|Actinobacteria 201174|Actinobacteria K PFAM regulatory protein TetR - - - - - - - - - - - - TetR_N k59_3723_2 365528.KB891245_gene6431 6.16e-38 139.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_111055_1 1121921.KB898716_gene26 0.000908 41.6 COG0848@1|root,COG0848@2|Bacteria,1RENY@1224|Proteobacteria,1S3TB@1236|Gammaproteobacteria,2PNP6@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria U Biopolymer transport protein ExbD/TolR - - - - - - - - - - - - ExbD k59_111055_2 1453501.JELR01000002_gene345 1.88e-28 110.0 COG0848@1|root,COG0848@2|Bacteria,1RHI8@1224|Proteobacteria,1S6FK@1236|Gammaproteobacteria,46BMC@72275|Alteromonadaceae 1236|Gammaproteobacteria U Biopolymer transport protein ExbD/TolR - - - - - - - - - - - - ExbD k59_477167_1 502025.Hoch_3797 1.54e-31 117.0 COG2036@1|root,COG2036@2|Bacteria,1N3S6@1224|Proteobacteria,42UYX@68525|delta/epsilon subdivisions,2WQE4@28221|Deltaproteobacteria 28221|Deltaproteobacteria B protein heterodimerization activity - - - - - - - - - - - - - k59_1626516_1 795359.TOPB45_0873 2.8e-10 65.1 COG0725@1|root,COG0725@2|Bacteria,2GIAT@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria P Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_11 k59_1417543_1 754476.Q7A_2508 1.11e-43 149.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,46014@72273|Thiotrichales 72273|Thiotrichales V Transport permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_1417543_2 1121921.KB898710_gene639 3.76e-69 219.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,2PMSH@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria V AAA domain, putative AbiEii toxin, Type IV TA system yadG GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1262776_1 880071.Fleli_0476 3.21e-66 223.0 COG0508@1|root,COG1115@1|root,COG0508@2|Bacteria,COG1115@2|Bacteria,4NDX7@976|Bacteroidetes,47JCJ@768503|Cytophagia 976|Bacteroidetes E PFAM Sodium alanine symporter family - - - ko:K03310 - - - - ko00000 2.A.25 - - Biotin_lipoyl,Na_Ala_symp,SprB k59_3724_2 1504981.KO116_0229 1.08e-27 108.0 COG1392@1|root,COG1392@2|Bacteria,1MXY9@1224|Proteobacteria,1RQHT@1236|Gammaproteobacteria,1XJD4@135619|Oceanospirillales 135619|Oceanospirillales P COG1392 Phosphate transport regulator (distant homolog of PhoU) - - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_268605_2 1379698.RBG1_1C00001G0712 1.34e-14 77.0 COG0612@1|root,COG0612@2|Bacteria,2NQPM@2323|unclassified Bacteria 2|Bacteria S Insulinase (Peptidase family M16) pqqL - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1052161_1 1430440.MGMSRv2_2053 8.61e-56 176.0 COG0745@1|root,COG0745@2|Bacteria,1RHCU@1224|Proteobacteria,2U98H@28211|Alphaproteobacteria,2JTBA@204441|Rhodospirillales 204441|Rhodospirillales T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_1052161_2 187272.Mlg_0668 9.17e-33 131.0 COG2176@1|root,COG5000@1|root,COG2176@2|Bacteria,COG5000@2|Bacteria,1QUVW@1224|Proteobacteria,1RM8J@1236|Gammaproteobacteria 1236|Gammaproteobacteria L dna polymerase III - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_161906_1 1122603.ATVI01000013_gene1323 2.56e-19 85.9 COG3040@1|root,COG3040@2|Bacteria,1RIKA@1224|Proteobacteria,1T0AA@1236|Gammaproteobacteria,1X6SY@135614|Xanthomonadales 135614|Xanthomonadales M Lipocalin-like domain blc4 - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_161906_2 177437.HRM2_44510 4.23e-67 218.0 COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,42YNG@68525|delta/epsilon subdivisions,2WU6B@28221|Deltaproteobacteria,2MN61@213118|Desulfobacterales 28221|Deltaproteobacteria L Integrase - - - - - - - - - - - - rve k59_321316_1 1121403.AUCV01000005_gene315 8.39e-12 69.7 COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2MHS8@213118|Desulfobacterales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_688082_1 316057.RPD_1536 3.88e-97 294.0 COG1924@1|root,COG1924@2|Bacteria,1R411@1224|Proteobacteria,2U1DN@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Benzoyl-CoA reductase subunit - - 1.3.7.8 ko:K04114 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - BcrAD_BadFG k59_1210696_1 663932.KB902575_gene2325 3.41e-46 167.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,2JPVD@204441|Rhodospirillales 204441|Rhodospirillales C Electron transfer flavoprotein-ubiquinone oxidoreductase - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_372870_1 589865.DaAHT2_0825 7.04e-94 294.0 COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria,2MIRV@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit - - 2.3.1.169 ko:K14138 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00377 R08433,R10243 RC00004,RC00113,RC01144,RC02963,RC02964,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhC k59_1156314_1 861299.J421_5638 1.13e-91 282.0 COG1524@1|root,COG1524@2|Bacteria 2|Bacteria S mannose-ethanolamine phosphotransferase activity - - - - - - - - - - - - Phosphodiest k59_1365415_1 1324957.K933_13883 1.02e-21 100.0 COG0534@1|root,arCOG01731@2157|Archaea,2XU54@28890|Euryarchaeota,23SKQ@183963|Halobacteria 183963|Halobacteria V COG0534 Na -driven multidrug efflux pump - - - - - - - - - - - - MatE k59_1470895_1 330214.NIDE3295 9.98e-49 167.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c ccoP - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrom_C,Cytochrome_CBB3,FixO k59_1470895_2 330214.NIDE3294 4.95e-226 625.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 k59_688097_2 204669.Acid345_4638 8.11e-47 164.0 COG2010@1|root,COG2010@2|Bacteria,3Y7CN@57723|Acidobacteria,2JK7I@204432|Acidobacteriia 204432|Acidobacteriia C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_161914_2 864702.OsccyDRAFT_0388 1.16e-137 414.0 COG1166@1|root,COG1166@2|Bacteria,1G1C4@1117|Cyanobacteria,1H8Q4@1150|Oscillatoriales 1117|Cyanobacteria E Catalyzes the biosynthesis of agmatine from arginine speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_529426_1 368407.Memar_1359 1.96e-07 56.2 COG0584@1|root,arCOG00701@2157|Archaea,2XXRI@28890|Euryarchaeota,2NB63@224756|Methanomicrobia 224756|Methanomicrobia C Glycerophosphoryl diester phosphodiesterase family glpQ - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_529426_2 309798.COPRO5265_0269 1.02e-13 71.2 COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,42FD3@68295|Thermoanaerobacterales 186801|Clostridia F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_581691_1 1394178.AWOO02000016_gene6924 3.72e-84 265.0 COG3185@1|root,COG3185@2|Bacteria,2GJNC@201174|Actinobacteria,4EM83@85012|Streptosporangiales 201174|Actinobacteria E Acyclic terpene utilisation family protein AtuA - - - - - - - - - - - - AtuA k59_529429_1 1448139.AI20_01580 2.12e-08 57.8 COG4531@1|root,COG4531@2|Bacteria,1N099@1224|Proteobacteria,1S9HM@1236|Gammaproteobacteria,1Y5VU@135624|Aeromonadales 135624|Aeromonadales P Protein of unknown function (DUF2796) - - - - - - - - - - - - DUF2796 k59_1519731_1 330214.NIDE1653 1.36e-58 194.0 COG1413@1|root,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity - - - - - - - - - - - - HEAT_2,zf-HC2 k59_738403_1 1221522.B723_27375 5.3e-51 177.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1YMIV@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria T response regulator pilR - - ko:K02481,ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_1470916_1 330214.NIDE2984 7.31e-115 344.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,3J0FF@40117|Nitrospirae 40117|Nitrospirae GM Belongs to the mannose-6-phosphate isomerase type 2 family - - 2.7.7.13,5.3.1.8 ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_1365431_1 522306.CAP2UW1_4328 1.84e-115 347.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VI77@28216|Betaproteobacteria,1KQJI@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria I Carboxyl transferase domain accB - 6.4.1.4 ko:K01969 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1210732_1 335543.Sfum_3371 2.01e-74 232.0 COG3823@1|root,COG3823@2|Bacteria,1R9YU@1224|Proteobacteria,42RYU@68525|delta/epsilon subdivisions,2WNVI@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM Glutamine cyclotransferase - - - - - - - - - - - - Glu_cyclase_2 k59_529438_1 1248232.BANQ01000088_gene2649 5.23e-64 206.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1XTGN@135623|Vibrionales 135623|Vibrionales M sugar phosphate isomerase involved in capsule formation kdsD - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_792718_1 946483.Cenrod_1991 9.72e-62 213.0 COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,4AD1S@80864|Comamonadaceae 28216|Betaproteobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,Pkinase k59_1262839_1 768671.ThimaDRAFT_3116 6.56e-86 266.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1WWNX@135613|Chromatiales 135613|Chromatiales E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_61553_1 1541065.JRFE01000073_gene3320 2.38e-80 254.0 COG3464@1|root,COG3464@2|Bacteria,1G42D@1117|Cyanobacteria,3VMW4@52604|Pleurocapsales 1117|Cyanobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_688129_1 436308.Nmar_1686 6.31e-73 227.0 COG0540@1|root,arCOG00911@2157|Archaea,41S6H@651137|Thaumarchaeota 651137|Thaumarchaeota F aspartate carbamoyltransferase pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_688129_2 436308.Nmar_1687 4.16e-39 133.0 COG1781@1|root,arCOG04229@2157|Archaea,41SJT@651137|Thaumarchaeota 651137|Thaumarchaeota F Involved in allosteric regulation of aspartate carbamoyltransferase pyrI - - ko:K00610 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002 - - - PyrI,PyrI_C k59_1312941_1 342113.DM82_6233 2.76e-63 205.0 COG4638@1|root,COG4638@2|Bacteria,1MXR2@1224|Proteobacteria,2VZ5R@28216|Betaproteobacteria,1K23F@119060|Burkholderiaceae 28216|Betaproteobacteria P PFAM Rieske 2Fe-2S - - - - - - - - - - - - Rieske k59_321351_2 1121033.AUCF01000001_gene2009 2.4e-11 63.2 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TR9N@28211|Alphaproteobacteria,2JQUC@204441|Rhodospirillales 204441|Rhodospirillales U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_1417608_1 1380394.JADL01000008_gene3643 2.13e-31 122.0 COG0412@1|root,COG0412@2|Bacteria,1R5J6@1224|Proteobacteria,2UE6V@28211|Alphaproteobacteria,2JUU3@204441|Rhodospirillales 204441|Rhodospirillales Q Dienelactone hydrolase family - - - - - - - - - - - - DLH k59_111115_1 1121878.AUGL01000034_gene2017 7.61e-125 364.0 COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,1RSNX@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives ylbG - - - - - - - - - - - HTH_29,rve,rve_2,rve_3 k59_738434_1 246194.CHY_1386 5.9e-09 58.9 2EHT2@1|root,33BIS@2|Bacteria,1VPKJ@1239|Firmicutes,24VUY@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_1312958_1 404589.Anae109_2957 7.94e-11 63.2 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,42MBH@68525|delta/epsilon subdivisions,2WK79@28221|Deltaproteobacteria,2YV9G@29|Myxococcales 28221|Deltaproteobacteria H aminotransferase - - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_644127_1 1207063.P24_16025 1.31e-47 162.0 COG1712@1|root,COG1712@2|Bacteria,1MX8S@1224|Proteobacteria,2TV48@28211|Alphaproteobacteria,2JREV@204441|Rhodospirillales 204441|Rhodospirillales H Domain of unknown function DUF108 - - - - - - - - - - - - DUF108,NAD_binding_3 k59_644127_2 1469613.JT55_15580 1.01e-19 89.4 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TQWP@28211|Alphaproteobacteria,3FDV1@34008|Rhodovulum 28211|Alphaproteobacteria E Gamma-glutamyltranspeptidase ywrD - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_901547_1 228410.NE0925 2.16e-07 51.2 COG2010@1|root,COG2010@2|Bacteria,1N63J@1224|Proteobacteria,2VVMT@28216|Betaproteobacteria,374A0@32003|Nitrosomonadales 28216|Betaproteobacteria C Cytochrome c, class I - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3 k59_587853_1 1235797.C816_04081 9.18e-17 84.7 COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,2N683@216572|Oscillospiraceae 186801|Clostridia I Psort location Cytoplasmic, score 9.97 bcd - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1270866_1 1266914.ATUK01000002_gene540 5.77e-10 67.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1RG8H@1224|Proteobacteria,1SMYF@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - GGDEF,PAS_3,PAS_4,PAS_9 k59_644132_1 118161.KB235922_gene3393 1.2e-77 247.0 COG1232@1|root,COG1232@2|Bacteria,1G05M@1117|Cyanobacteria 1117|Cyanobacteria H Protoporphyrinogen oxidase - - - - - - - - - - - - Amino_oxidase k59_485320_1 585425.KR52_03690 4.49e-42 156.0 COG0317@1|root,COG0317@2|Bacteria,1G0KC@1117|Cyanobacteria,1GZG8@1129|Synechococcus 1117|Cyanobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_901551_1 1227499.C493_20932 1.29e-60 211.0 COG0643@1|root,arCOG04403@2157|Archaea,2XSUS@28890|Euryarchaeota,23T9R@183963|Halobacteria 183963|Halobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,P2 k59_694283_1 883078.HMPREF9695_02679 1e-46 162.0 COG2271@1|root,COG2271@2|Bacteria,1NJTU@1224|Proteobacteria,2TUBJ@28211|Alphaproteobacteria,3JU19@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Major Facilitator Superfamily MA20_01130 - - - - - - - - - - - MFS_1 k59_1425284_1 526227.Mesil_2739 3.78e-38 141.0 COG0438@1|root,COG0438@2|Bacteria,1WJWQ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_6347_1 66875.JODY01000006_gene2209 5.62e-32 125.0 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria 201174|Actinobacteria J Belongs to the amidase family amiC_1 - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_379834_1 768671.ThimaDRAFT_1475 5.97e-106 329.0 COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,1RZMQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Recombinase - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom k59_222417_1 436308.Nmar_1511 3.47e-93 285.0 COG0172@1|root,arCOG00403@2157|Archaea,41SC9@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_1110521_1 1229909.NSED_05220 1.05e-84 259.0 COG0367@1|root,arCOG00071@2157|Archaea,41SMA@651137|Thaumarchaeota 651137|Thaumarchaeota E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase k59_1161461_1 1121438.JNJA01000001_gene2487 3.51e-33 132.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2M859@213115|Desulfovibrionales 28221|Deltaproteobacteria C xanthine dehydrogenase, a b hammerhead - - 1.17.1.5 ko:K20447 ko00760,ko01120,map00760,map01120 - R01720 RC00589 ko00000,ko00001,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2 k59_327385_1 1366050.N234_36590 1.79e-40 150.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria,1K21K@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA polymerase - - - - - - - - - - - - GIIM,RVT_1 k59_1270886_1 644801.Psest_2141 1.58e-13 75.1 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RQ6B@1236|Gammaproteobacteria,1Z03N@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria MU COG1538 Outer membrane protein - - - - - - - - - - - - OEP k59_801210_1 177439.DP2198 1.24e-07 55.5 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria,2MHKT@213118|Desulfobacterales 28221|Deltaproteobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_69517_1 395493.BegalDRAFT_2999 6.35e-90 278.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,461WQ@72273|Thiotrichales 72273|Thiotrichales E Glutamine synthetase, catalytic domain - - - - - - - - - - - - Gln-synt_C k59_117643_1 436308.Nmar_0629 4.01e-81 245.0 arCOG01781@1|root,arCOG01781@2157|Archaea,41T0U@651137|Thaumarchaeota 651137|Thaumarchaeota Q Protein of unknown function (DUF1698) - - - - - - - - - - - - Methyltransf_11 k59_1058274_1 357808.RoseRS_2371 3.68e-53 184.0 COG0438@1|root,COG0438@2|Bacteria,2G9B8@200795|Chloroflexi,376I5@32061|Chloroflexia 32061|Chloroflexia H PFAM glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1058274_2 357808.RoseRS_2375 5.38e-41 159.0 COG3307@1|root,COG3307@2|Bacteria,2GB55@200795|Chloroflexi,377AJ@32061|Chloroflexia 32061|Chloroflexia M PFAM O-antigen polymerase - - - - - - - - - - - - Wzy_C k59_1005462_1 756272.Plabr_3400 1.62e-19 95.1 COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,2IWVF@203682|Planctomycetes 203682|Planctomycetes T FHA domain - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - FHA,GAF_2,SpoIIE k59_1478926_1 745014.OMB55_00011440 5.88e-77 253.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,1RZZE@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the GcvT family - - - - - - - - - - - - DAO,FAO_M,GCV_T,GCV_T_C k59_379864_1 1286106.MPL1_01687 7.45e-55 189.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,460EP@72273|Thiotrichales 72273|Thiotrichales G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) - - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_1161477_1 649747.HMPREF0083_01846 3.44e-70 235.0 COG0674@1|root,COG1013@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,1TPF0@1239|Firmicutes,4HCVY@91061|Bacilli,26R4C@186822|Paenibacillaceae 91061|Bacilli C Pyruvate synthase porA - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N,TPP_enzyme_C k59_1523794_1 1265503.KB905161_gene3389 1.75e-11 63.5 COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,1S3Y1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Periplasmic Protein - - - - - - - - - - - - Peptidase_C93 k59_1523794_2 686340.Metal_3585 6.7e-22 98.6 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MUQV@1224|Proteobacteria,1RN0Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria T GGDEF domain - - - - - - - - - - - - EAL,GGDEF,LapD_MoxY_N k59_1425340_1 1304877.KI519399_gene3442 1.74e-08 54.3 COG2128@1|root,COG2128@2|Bacteria,1R4FX@1224|Proteobacteria,2TTF7@28211|Alphaproteobacteria,3JSUS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Carboxymuconolactone decarboxylase family MA20_10015 - - - - - - - - - - - CMD k59_1425340_2 1121936.AUHI01000006_gene1966 6.82e-21 95.1 COG0154@1|root,COG0154@2|Bacteria,1TPGJ@1239|Firmicutes,4HBE7@91061|Bacilli 91061|Bacilli J Belongs to the amidase family - - 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_644203_1 314230.DSM3645_09757 2.31e-11 64.7 2E13Z@1|root,32WJ8@2|Bacteria,2J0YS@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - k59_644203_2 1445613.JALM01000073_gene6853 3.11e-05 47.4 COG0300@1|root,COG3320@1|root,COG0300@2|Bacteria,COG3320@2|Bacteria,2GJ1R@201174|Actinobacteria,4EDVD@85010|Pseudonocardiales 201174|Actinobacteria M Male sterility protein - - - - - - - - - - - - NAD_binding_4,adh_short k59_801262_1 765912.Thimo_1468 1.32e-61 202.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1WW57@135613|Chromatiales 135613|Chromatiales F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily - - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_801262_2 551275.KB899548_gene121 0.000342 40.8 COG3492@1|root,COG3492@2|Bacteria,1MZ3I@1224|Proteobacteria,2UC11@28211|Alphaproteobacteria,43YEP@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1244) MA20_03865 - - ko:K09948 - - - - ko00000 - - - DUF1244 k59_644210_1 1120956.JHZK01000001_gene3372 3.12e-81 248.0 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2U4QB@28211|Alphaproteobacteria,1JPPQ@119043|Rhodobiaceae 28211|Alphaproteobacteria Q Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_1523805_1 639282.DEFDS_0188 2.03e-48 165.0 COG0846@1|root,COG0846@2|Bacteria,2GFEB@200930|Deferribacteres 200930|Deferribacteres K Sir2 family - - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_379925_1 330214.NIDE0206 3.7e-86 257.0 COG2138@1|root,COG2138@2|Bacteria 2|Bacteria S sirohydrochlorin cobaltochelatase activity - - - - - - - - - - - - - k59_379925_2 330214.NIDE0204 9.58e-76 234.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,3J13F@40117|Nitrospirae 40117|Nitrospirae S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_1161511_1 378806.STAUR_2315 9.89e-51 177.0 COG1090@1|root,COG4276@1|root,COG1090@2|Bacteria,COG4276@2|Bacteria,1MUB4@1224|Proteobacteria,42PQ2@68525|delta/epsilon subdivisions,2WK6V@28221|Deltaproteobacteria,2YUBK@29|Myxococcales 28221|Deltaproteobacteria S Domain of unknown function (DUF1731) - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase,Polyketide_cyc k59_953156_1 1121875.KB907548_gene1629 6.44e-58 199.0 COG0668@1|root,COG0668@2|Bacteria,4NHU7@976|Bacteroidetes,1I0RF@117743|Flavobacteriia 976|Bacteroidetes M Mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_1058334_1 589865.DaAHT2_2107 1.33e-100 315.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,2MHSK@213118|Desulfobacterales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1371544_1 1123242.JH636434_gene5045 1.2e-156 458.0 COG0076@1|root,COG0076@2|Bacteria,2IZNW@203682|Planctomycetes 203682|Planctomycetes E Pyridoxal-dependent decarboxylase conserved domain - - - - - - - - - - - - Pyridoxal_deC k59_587940_1 639282.DEFDS_1552 7.02e-56 193.0 COG0173@1|root,COG0173@2|Bacteria,2GEX7@200930|Deferribacteres 200930|Deferribacteres J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_587940_2 485915.Dret_1125 2.29e-28 127.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,4305Z@68525|delta/epsilon subdivisions,2WNZQ@28221|Deltaproteobacteria,2MH93@213115|Desulfovibrionales 28221|Deltaproteobacteria T Diguanylate cyclase with PAS PAC sensor - - - - - - - - - - - - GGDEF,PAS_3,PAS_4,PAS_9,Response_reg k59_168118_1 1049564.TevJSym_bj00030 1.86e-41 153.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1J4TI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - iJN746.PP_4935,iPC815.YPO1395,iUMN146_1321.UM146_12980 ABC_membrane,ABC_tran k59_1579988_2 693986.MOC_3861 3.02e-20 87.8 COG3427@1|root,COG3427@2|Bacteria,1QZZ3@1224|Proteobacteria,2TYH6@28211|Alphaproteobacteria,1JUKG@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 k59_1270987_1 1415754.JQMK01000013_gene117 1.73e-53 179.0 COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,1RS6A@1236|Gammaproteobacteria,469SU@72275|Alteromonadaceae 1236|Gammaproteobacteria C C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the intermediary formation of conspicuous sulfur globules inside of the cells soxA - 1.8.2.2 ko:K17222,ko:K19713 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 - - - - k59_1270987_2 1458427.BAWN01000003_gene133 1.03e-05 46.6 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,2VU95@28216|Betaproteobacteria,4AEQV@80864|Comamonadaceae 28216|Betaproteobacteria S Sulphur oxidation protein SoxZ soxZ - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_1270987_3 1217718.ALOU01000009_gene1097 4.5e-14 69.7 COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2VT8I@28216|Betaproteobacteria,1K740@119060|Burkholderiaceae 28216|Betaproteobacteria S Sulfur oxidation protein SoxY soxY - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY k59_694380_1 742817.HMPREF9449_02657 1.14e-29 117.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,4NEP3@976|Bacteroidetes,2FN08@200643|Bacteroidia,22WBU@171551|Porphyromonadaceae 976|Bacteroidetes C 2-oxoacid acceptor oxidoreductase, alpha subunit porA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_694380_2 28115.HR11_00465 1.27e-35 130.0 COG1013@1|root,COG1013@2|Bacteria,4NIE0@976|Bacteroidetes,2FME7@200643|Bacteroidia,22VVU@171551|Porphyromonadaceae 976|Bacteroidetes C ferredoxin oxidoreductase subunit beta oorB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_1005532_1 1279017.AQYJ01000025_gene537 2.02e-81 259.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,463YB@72275|Alteromonadaceae 1236|Gammaproteobacteria E Oxidoreductase neoG - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_70575_1 525897.Dbac_1998 5.86e-52 178.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,2M7YC@213115|Desulfovibrionales 28221|Deltaproteobacteria L DEAD DEAH box helicase domain protein rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_695153_1 351348.Maqu_0712 6.74e-72 242.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,464QF@72275|Alteromonadaceae 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_328257_1 1167006.UWK_00703 1.02e-49 177.0 COG0038@1|root,COG0517@1|root,COG0569@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,COG0569@2|Bacteria,1MV4K@1224|Proteobacteria,42N93@68525|delta/epsilon subdivisions,2WJ9N@28221|Deltaproteobacteria,2MHX8@213118|Desulfobacterales 28221|Deltaproteobacteria P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,TrkA_C,Voltage_CLC k59_118720_1 926561.KB900618_gene236 6.76e-09 58.5 COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,25C37@186801|Clostridia,3WAP3@53433|Halanaerobiales 186801|Clostridia M PPIC-type PPIASE domain - - 5.2.1.8 ko:K03769,ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Cu_amine_oxidN1,Rotamase_2,Rotamase_3,SurA_N_3 k59_849964_1 337191.KTR9_4659 1.14e-10 63.9 COG0493@1|root,COG0493@2|Bacteria,2GJ4A@201174|Actinobacteria,4GA46@85026|Gordoniaceae 201174|Actinobacteria C 4Fe-4S binding domain - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - Fer4,Pyr_redox_2 k59_849964_2 686340.Metal_0404 2.49e-64 215.0 COG1029@1|root,COG1029@2|Bacteria,1R64R@1224|Proteobacteria,1RNM2@1236|Gammaproteobacteria,1XDZR@135618|Methylococcales 135618|Methylococcales C TIGRFAM formylmethanofuran dehydrogenase subunit B - - 1.2.7.12 ko:K00201 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - - k59_168873_1 40149.OMERI01G06580.1 4.93e-56 199.0 COG0152@1|root,KOG2835@2759|Eukaryota,37SAJ@33090|Viridiplantae,3GC4Z@35493|Streptophyta,3KTGR@4447|Liliopsida,3I7D6@38820|Poales 35493|Streptophyta F AIR carboxylase - - 4.1.1.21 ko:K11808 ko00230,ko01100,ko01110,map00230,map01100,map01110 M00048 R04209 RC00590 ko00000,ko00001,ko00002,ko01000 - - - AIRC,ATP-grasp,DUF1677 k59_275560_1 765911.Thivi_2848 7.97e-32 113.0 COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,1SCMH@1236|Gammaproteobacteria,1WZ1M@135613|Chromatiales 135613|Chromatiales J 50S ribosomal protein L31 rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_275560_2 402626.Rpic_1031 1.29e-37 137.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2VJ2E@28216|Betaproteobacteria,1JZZX@119060|Burkholderiaceae 28216|Betaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_1580770_1 696747.NIES39_E03390 3.25e-22 95.5 COG2270@1|root,COG2270@2|Bacteria,1G3YB@1117|Cyanobacteria,1HA0N@1150|Oscillatoriales 1117|Cyanobacteria S Vacuole effluxer Atg22 like - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_1272016_1 1121935.AQXX01000130_gene2485 8.77e-27 105.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,1RNXH@1236|Gammaproteobacteria,1XIVQ@135619|Oceanospirillales 135619|Oceanospirillales C Aldo keto reductase tas - - - - - - - - - - - Aldo_ket_red k59_1272016_2 748247.AZKH_2773 1.93e-135 385.0 COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,2VK8F@28216|Betaproteobacteria,2KWZJ@206389|Rhodocyclales 206389|Rhodocyclales O C-terminal domain of 1-Cys peroxiredoxin - - - - - - - - - - - - 1-cysPrx_C,AhpC-TSA k59_536313_1 489825.LYNGBM3L_63500 4.77e-49 175.0 COG5421@1|root,COG5421@2|Bacteria,1G3YW@1117|Cyanobacteria,1HHRP@1150|Oscillatoriales 1117|Cyanobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1 k59_118747_1 1123401.JHYQ01000008_gene343 1.25e-78 246.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,4626H@72273|Thiotrichales 72273|Thiotrichales NU PFAM Type II IV secretion system protein - - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1524380_1 886293.Sinac_3249 7.76e-96 308.0 COG0209@1|root,COG0209@2|Bacteria,2IX3H@203682|Planctomycetes 203682|Planctomycetes F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC k59_431955_1 1526927.Plano_2770 9.46e-44 156.0 COG3264@1|root,COG3264@2|Bacteria,1UIZT@1239|Firmicutes,4HCE1@91061|Bacilli 91061|Bacilli M Small-conductance mechanosensitive channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_1272029_1 1265505.ATUG01000003_gene167 3.23e-08 53.9 COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,42SST@68525|delta/epsilon subdivisions,2WPWN@28221|Deltaproteobacteria,2MK4F@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM PTS system fructose subfamily IIA component - - 2.7.1.191 ko:K02793 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1 - - EIIA-man k59_1272029_2 767434.Fraau_1262 2.04e-41 146.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1X3TG@135614|Xanthomonadales 135614|Xanthomonadales S Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_802350_1 1502851.FG93_05058 4.63e-59 204.0 COG0421@1|root,COG0421@2|Bacteria,1PD54@1224|Proteobacteria,2V9CT@28211|Alphaproteobacteria,3JYAK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Spermine/spermidine synthase domain - - - - - - - - - - - - Spermine_synth k59_328286_1 1132855.KB913035_gene35 1.07e-52 178.0 COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHMW@28216|Betaproteobacteria,2KM3Q@206350|Nitrosomonadales 206350|Nitrosomonadales KLT SMART serine threonine protein kinase - - - - - - - - - - - - Pkinase k59_389623_2 1123392.AQWL01000003_gene264 2.19e-19 87.4 COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,2VQEZ@28216|Betaproteobacteria,1KSGG@119069|Hydrogenophilales 119069|Hydrogenophilales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_1167705_1 330214.NIDE0245 1.99e-55 192.0 COG0260@1|root,COG0260@2|Bacteria,3J0X7@40117|Nitrospirae 40117|Nitrospirae E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_335407_1 861299.J421_0248 2.96e-35 138.0 COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,1ZUXK@142182|Gemmatimonadetes 2|Bacteria T AAA ATPase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,Trans_reg_C k59_80194_2 350058.Mvan_0013 4.83e-36 135.0 COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,232XA@1762|Mycobacteriaceae 201174|Actinobacteria C alcohol dehydrogenase - - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1642649_1 1162668.LFE_0880 6.07e-110 327.0 COG0050@1|root,COG0050@2|Bacteria,3J0DG@40117|Nitrospirae 40117|Nitrospirae J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis - - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_1167706_1 937777.Deipe_2279 3.57e-52 172.0 COG1116@1|root,COG1116@2|Bacteria,1WM71@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P ABC-type nitrate sulfonate bicarbonate transport system ATPase component - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_230199_1 1041146.ATZB01000008_gene2192 9.68e-17 81.6 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_543185_1 1049564.TevJSym_bb00030 1.74e-31 129.0 COG1013@1|root,COG1013@2|Bacteria,1R28U@1224|Proteobacteria 1224|Proteobacteria C 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - - - - - - - - - - TPP_enzyme_C k59_654890_1 1078020.KEK_05482 2.13e-29 117.0 COG1073@1|root,COG1073@2|Bacteria,2I8SP@201174|Actinobacteria,234F7@1762|Mycobacteriaceae 201174|Actinobacteria S alpha beta - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - - k59_654890_2 1313172.YM304_03080 0.000989 42.4 COG1075@1|root,COG1075@2|Bacteria,2GJGC@201174|Actinobacteria 201174|Actinobacteria S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - - k59_496090_1 999541.bgla_2g21200 1.72e-42 158.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,1K0BR@119060|Burkholderiaceae 28216|Betaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_440241_1 713586.KB900536_gene299 1.99e-102 330.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales 135613|Chromatiales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1324104_1 1266925.JHVX01000001_gene2540 3.5e-110 327.0 COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,2VHKN@28216|Betaproteobacteria,37213@32003|Nitrosomonadales 28216|Betaproteobacteria P Zinc-uptake complex component A periplasmic - - - ko:K02077,ko:K09815,ko:K11604,ko:K11707 ko02010,map02010 M00242,M00244,M00317,M00319 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5,3.A.1.15.7,3.A.1.15.9 - - ZnuA k59_1226364_1 1122175.ATXU01000009_gene1901 1.12e-07 56.2 COG1216@1|root,COG1216@2|Bacteria,2I2J1@201174|Actinobacteria,4FNBW@85023|Microbacteriaceae 201174|Actinobacteria S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1226364_2 489825.LYNGBM3L_64070 4.83e-54 186.0 COG0438@1|root,COG0438@2|Bacteria,1G1X1@1117|Cyanobacteria,1H8D4@1150|Oscillatoriales 1117|Cyanobacteria M PFAM Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_702411_1 626887.J057_00070 5.55e-73 226.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_25 k59_80229_1 572477.Alvin_2384 1.02e-55 192.0 COG0457@1|root,COG5010@1|root,COG0457@2|Bacteria,COG5010@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1WWY6@135613|Chromatiales 135613|Chromatiales U Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 k59_1489552_1 484019.THA_576 1.51e-16 86.3 COG2203@1|root,COG5000@1|root,COG2203@2|Bacteria,COG5000@2|Bacteria,2GCCB@200918|Thermotogae 200918|Thermotogae T Histidine kinase - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_4 k59_909839_1 1380356.JNIK01000013_gene4169 3.31e-06 52.4 COG4907@1|root,COG4907@2|Bacteria,2GNW7@201174|Actinobacteria 201174|Actinobacteria S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_909839_2 926567.TheveDRAFT_1297 7.19e-05 44.3 COG1704@1|root,COG1704@2|Bacteria,3TAYK@508458|Synergistetes 508458|Synergistetes S PFAM LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_543204_1 1165096.ARWF01000001_gene2322 9.12e-47 178.0 COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,2VI9X@28216|Betaproteobacteria,2KM66@206350|Nitrosomonadales 206350|Nitrosomonadales S Protein conserved in bacteria - - - - - - - - - - - - - k59_909840_1 1283300.ATXB01000001_gene819 6.01e-25 100.0 COG1618@1|root,COG1618@2|Bacteria,1N4XQ@1224|Proteobacteria 1224|Proteobacteria F NTPase - - - - - - - - - - - - NTPase_1 k59_909840_2 526225.Gobs_2522 6.86e-90 271.0 COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria,4ERK6@85013|Frankiales 201174|Actinobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - - - - - - - - - - - ECH_1 k59_10106_1 55601.VANGNB10_cII0131c 1.51e-86 267.0 COG3633@1|root,COG3633@2|Bacteria,1MXE1@1224|Proteobacteria,1RP9B@1236|Gammaproteobacteria,1XSMF@135623|Vibrionales 135623|Vibrionales E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) sstT GO:0003674,GO:0005215,GO:0005310,GO:0005342,GO:0005343,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006835,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015081,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015672,GO:0015711,GO:0015849,GO:0017153,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1903825,GO:1905039 - ko:K07862 - - - - ko00000,ko02000 2.A.23.4 - - SDF k59_10106_2 1261545.MBE-HAL_0168 2.56e-07 53.1 COG3174@1|root,arCOG04203@2157|Archaea,2XT0W@28890|Euryarchaeota,23S01@183963|Halobacteria 183963|Halobacteria P membrane - - - - - - - - - - - - DUF4010,MgtC k59_440272_1 344747.PM8797T_00899 2.14e-75 241.0 COG0702@1|root,COG0702@2|Bacteria,2IYQV@203682|Planctomycetes 203682|Planctomycetes GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - DUF2867,NAD_binding_10 k59_812036_1 1123024.AUII01000003_gene3487 2.81e-71 228.0 COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,4DZJ7@85010|Pseudonocardiales 201174|Actinobacteria Q Cytochrome P450 cyp - 1.14.15.14 ko:K20497 - - - - ko00000,ko00199,ko01000 - - - p450 k59_497404_1 392500.Swoo_2399 1.39e-54 181.0 COG0693@1|root,COG0693@2|Bacteria,1MVTT@1224|Proteobacteria,1RPVK@1236|Gammaproteobacteria,2QAE2@267890|Shewanellaceae 1236|Gammaproteobacteria S PFAM ThiJ PfpI domain protein - - - - - - - - - - - - DJ-1_PfpI k59_390431_1 472759.Nhal_2430 9.53e-114 345.0 COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1X03E@135613|Chromatiales 135613|Chromatiales C Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit - - 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_961901_1 865937.Gilli_1070 2.1e-16 78.2 arCOG09486@1|root,2ZC3Y@2|Bacteria,4NNUF@976|Bacteroidetes,1I367@117743|Flavobacteriia 976|Bacteroidetes S Glycosyl transferase family 11 - - - - - - - - - - - - Glyco_transf_11 k59_961901_2 610130.Closa_3476 4.8e-17 85.9 COG2605@1|root,COG2605@2|Bacteria,1UKBI@1239|Firmicutes,25D2Q@186801|Clostridia 186801|Clostridia S GHMP kinase - - 2.7.1.168 ko:K07031 ko00540,map00540 - R09770 RC00002,RC00078 ko00000,ko00001,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_1227765_1 1120980.JQKH01000001_gene627 6.43e-17 79.3 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2VHNK@28216|Betaproteobacteria,2KPK8@206351|Neisseriales 206351|Neisseriales D CobQ CobB MinD ParA nucleotide binding domain protein soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1227765_2 314231.FP2506_15399 2.13e-21 94.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria,2PJJW@255475|Aurantimonadaceae 28211|Alphaproteobacteria K ParB-like nuclease domain parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_1227768_1 1042375.AFPL01000029_gene3473 2.55e-117 351.0 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,464Z4@72275|Alteromonadaceae 1236|Gammaproteobacteria E alanine symporter dagA - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_336437_1 1244869.H261_01542 1.22e-09 61.6 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2TRD8@28211|Alphaproteobacteria,2JPAB@204441|Rhodospirillales 204441|Rhodospirillales O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_336437_2 1123360.thalar_02885 3.16e-50 176.0 COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2U068@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome C and Quinol oxidase polypeptide I - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_813332_1 485913.Krac_11488 2.18e-05 52.4 COG0457@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3903@2|Bacteria,2G71Q@200795|Chloroflexi 200795|Chloroflexi NU TPR repeat-containing protein - - - - - - - - - - - - HTH_31,NB-ARC,TPR_10,TPR_12,TPR_7 k59_1437121_1 401526.TcarDRAFT_2158 5.07e-66 213.0 COG1063@1|root,COG1063@2|Bacteria,1U5GN@1239|Firmicutes 1239|Firmicutes E PFAM Alcohol dehydrogenase zinc-binding domain protein - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_497434_1 1286170.RORB6_16110 0.00016 50.4 COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RYA3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos k59_1490917_1 1123261.AXDW01000009_gene110 2.88e-86 273.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1X34U@135614|Xanthomonadales 135614|Xanthomonadales I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_910876_1 519989.ECTPHS_06847 1.15e-16 77.8 COG0457@1|root,COG0457@2|Bacteria,1QW39@1224|Proteobacteria 1224|Proteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - Sulfotransfer_2 k59_910876_2 396588.Tgr7_2880 7.03e-32 116.0 COG5615@1|root,COG5615@2|Bacteria,1RH6D@1224|Proteobacteria,1S6S2@1236|Gammaproteobacteria,1WZE3@135613|Chromatiales 135613|Chromatiales S Copper resistance protein D - - - - - - - - - - - - CopD k59_1437123_2 1121403.AUCV01000014_gene4561 3.54e-112 352.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,2MHV4@213118|Desulfobacterales 28221|Deltaproteobacteria M Penicillin-binding Protein dimerisation domain mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_0928 PBP_dimer,Transpeptidase k59_1530346_1 879309.HMPREF9199_0310 2.24e-33 125.0 COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,4H2MH@909932|Negativicutes 909932|Negativicutes E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1530346_2 999541.bgla_2g18110 1.33e-60 196.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2VI78@28216|Betaproteobacteria,1K2CE@119060|Burkholderiaceae 28216|Betaproteobacteria E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_1227794_1 237368.SCABRO_02747 2.8e-30 115.0 COG0745@1|root,COG0745@2|Bacteria,2IX2M@203682|Planctomycetes 203682|Planctomycetes K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K07657,ko:K07662 ko01503,ko02020,map01503,map02020 M00434,M00447,M00727,M00728 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1227794_2 517417.Cpar_0658 8.71e-08 53.1 COG5002@1|root,COG5002@2|Bacteria,1FE54@1090|Chlorobi 1090|Chlorobi T histidine kinase HAMP region domain protein - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS k59_813352_2 1121459.AQXE01000001_gene2762 2.23e-14 73.6 2BICQ@1|root,32CIU@2|Bacteria,1Q6ZR@1224|Proteobacteria,43726@68525|delta/epsilon subdivisions,2X1TE@28221|Deltaproteobacteria,2MFN8@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1067636_1 1121940.AUDZ01000007_gene2297 4.22e-33 129.0 COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,1S1GU@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - - - - - - - - - - DUF1485,MlrC_C k59_1530349_1 330214.NIDE3474 8.58e-79 262.0 COG0841@1|root,COG0841@2|Bacteria,3J0FA@40117|Nitrospirae 40117|Nitrospirae V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296,ko:K18138,ko:K19585 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718,M00767 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.47 - - ACR_tran k59_336459_1 395493.BegalDRAFT_2410 1.35e-108 333.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,4605A@72273|Thiotrichales 72273|Thiotrichales P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_703424_1 1192034.CAP_7279 4.73e-12 71.6 COG1520@1|root,COG1520@2|Bacteria,1R0E4@1224|Proteobacteria,43EEC@68525|delta/epsilon subdivisions,2X84M@28221|Deltaproteobacteria,2YUU3@29|Myxococcales 28221|Deltaproteobacteria S FG-GAP repeat - - - - - - - - - - - - FG-GAP_2 k59_1067640_1 653733.Selin_1787 1.18e-85 276.0 COG0046@1|root,COG0046@2|Bacteria 2|Bacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_128760_1 1121937.AUHJ01000001_gene451 3.31e-21 98.6 28JDP@1|root,2Z97Z@2|Bacteria,1R6U7@1224|Proteobacteria,1S0CD@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_390451_2 1121439.dsat_0008 6.56e-05 50.8 29E55@1|root,30133@2|Bacteria,1Q6KF@1224|Proteobacteria,43ERX@68525|delta/epsilon subdivisions,2X1HJ@28221|Deltaproteobacteria,2MF2T@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1168514_1 551275.KB899544_gene1043 1.8e-45 167.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TQMV@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Glucose dehydrogenase quiA - 1.1.5.8 ko:K05358 ko00400,ko01100,ko01110,ko01130,map00400,map01100,map01110,map01130 - R01873,R02415 RC00154,RC00206 ko00000,ko00001,ko01000 - - - PQQ k59_597017_1 748658.KB907315_gene2552 3.07e-39 132.0 COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,1SCYV@1236|Gammaproteobacteria,1WZ82@135613|Chromatiales 135613|Chromatiales K TIGRFAM Addiction module antidote protein, HigA - - - ko:K21498 - - - - ko00000,ko02048 - - - HTH_3 k59_1014773_1 312153.Pnuc_2048 8.02e-25 100.0 2E560@1|root,32ZYT@2|Bacteria,1N9G1@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_656299_2 744979.R2A130_1394 5.07e-17 82.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.96 ko:K16871 ko00250,ko00650,ko01100,ko01120,map00250,map00650,map01100,map01120 M00027 R10178 RC00008,RC00062 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_3 k59_231258_1 257313.BP0086 1.6e-05 49.7 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2WERP@28216|Betaproteobacteria,3T70K@506|Alcaligenaceae 28216|Betaproteobacteria H Glycosyl transferase 4-like bplH - - - - - - - - - - - Glyco_trans_4_2,Glycos_transf_1 k59_656308_1 1123023.JIAI01000001_gene6239 0.000336 47.8 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4E0VC@85010|Pseudonocardiales 201174|Actinobacteria IQ Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II fadD5 - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_753550_2 330214.NIDE1286 1.95e-13 71.2 COG1413@1|root,COG1413@2|Bacteria,3J1E2@40117|Nitrospirae 40117|Nitrospirae C Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - HEAT_2,HEAT_PBS k59_597042_1 123214.PERMA_0029 1.48e-90 281.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2G3NT@200783|Aquificae 200783|Aquificae F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_1119560_1 267608.RSc1496 1.82e-35 135.0 COG0457@1|root,COG0457@2|Bacteria,1NQXN@1224|Proteobacteria,2W17K@28216|Betaproteobacteria 28216|Betaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1067672_1 696281.Desru_2946 0.000194 51.2 COG3209@1|root,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia,263Z8@186807|Peptococcaceae 186801|Clostridia M TIGRFAM RHS repeat-associated core domain - - - - - - - - - - - - F5_F8_type_C,PT-HINT,RHS_repeat k59_1490971_1 266264.Rmet_4579 5.21e-13 69.3 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2W0NK@28216|Betaproteobacteria,1K0G7@119060|Burkholderiaceae 28216|Betaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_961969_1 1348663.KCH_69690 3.75e-30 123.0 COG0492@1|root,COG2890@1|root,COG0492@2|Bacteria,COG2890@2|Bacteria,2GIXN@201174|Actinobacteria,2M218@2063|Kitasatospora 201174|Actinobacteria JO Thiopurine S-methyltransferase (TPMT) - - - - - - - - - - - - Methyltransf_25,Pyr_redox_2 k59_1490973_1 1265505.ATUG01000001_gene3573 6.77e-71 234.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2MIU8@213118|Desulfobacterales 28221|Deltaproteobacteria P Citrate transporter - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_604814_1 388401.RB2150_03678 4.37e-45 156.0 COG0006@1|root,COG0006@2|Bacteria,1NTWB@1224|Proteobacteria,2TRKF@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Xaa-Pro aminopeptidase pepQ - 3.4.13.9 ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_1502288_1 211165.AJLN01000108_gene559 1.69e-28 115.0 COG0583@1|root,COG0583@2|Bacteria,1G3WW@1117|Cyanobacteria,1JMRU@1189|Stigonemataceae 1117|Cyanobacteria K Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_1502289_1 756067.MicvaDRAFT_2865 3.4e-15 77.0 COG2234@1|root,COG2234@2|Bacteria,1G1QW@1117|Cyanobacteria,1H7N7@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 k59_1502289_2 983917.RGE_08670 6.98e-16 71.2 COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,2VTZ1@28216|Betaproteobacteria,1KMCZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria C 4Fe-4S binding domain fdx1 - - - - - - - - - - - Fer4,Fer4_7 k59_1446274_1 999141.GME_14335 5.28e-44 148.0 COG0789@1|root,COG0789@2|Bacteria,1RJD4@1224|Proteobacteria,1S8DH@1236|Gammaproteobacteria,1XKGY@135619|Oceanospirillales 135619|Oceanospirillales K Transcriptional - - - - - - - - - - - - MerR,MerR-DNA-bind,MerR_1 k59_93896_2 882378.RBRH_02294 9.8e-19 84.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2VIF9@28216|Betaproteobacteria,1K2AQ@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG k59_453369_1 298655.KI912266_gene785 3.31e-71 233.0 COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,4EUI2@85013|Frankiales 201174|Actinobacteria S 40-residue YVTN family beta-propeller repeat - - - - - - - - - - - - Lactonase k59_1447236_1 1168065.DOK_07229 1.02e-73 231.0 COG0693@1|root,COG0693@2|Bacteria,1PR9W@1224|Proteobacteria,1S114@1236|Gammaproteobacteria,1J7K8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S intracellular protease amidase - - - - - - - - - - - - DJ-1_PfpI k59_1333186_1 472759.Nhal_2746 1.54e-31 119.0 COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,1RPAD@1236|Gammaproteobacteria,1WVYN@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_1333186_2 83406.HDN1F_00910 0.000834 45.1 COG3159@1|root,COG3159@2|Bacteria,1RD7B@1224|Proteobacteria,1S539@1236|Gammaproteobacteria,1JBVY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function, DUF484 - - - ko:K09921 - - - - ko00000 - - - DUF484 k59_605690_1 765914.ThisiDRAFT_0194 5.02e-15 71.2 COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,1SA62@1236|Gammaproteobacteria,1WYYD@135613|Chromatiales 135613|Chromatiales G system, fructose subfamily IIA component - - 2.7.1.194 ko:K02821 ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 M00283,M00550 R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.7.1 - - EIIA-man k59_605690_2 443152.MDG893_01495 4.67e-26 99.0 COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,1SCXX@1236|Gammaproteobacteria,468BC@72275|Alteromonadaceae 1236|Gammaproteobacteria G COG1925 Phosphotransferase system, HPr-related proteins ptsO GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006808,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009401,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0065007,GO:0071702,GO:0071704,GO:1901564,GO:1901698 - ko:K08485,ko:K11189 ko02060,map02060 - - - ko00000,ko00001,ko02000 4.A.2.1 - - PTS-HPr k59_605690_3 105559.Nwat_0288 1.47e-48 172.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1WWBU@135613|Chromatiales 135613|Chromatiales G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) - - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_669188_1 1131269.AQVV01000009_gene1119 4.55e-111 332.0 COG0476@1|root,COG0476@2|Bacteria 2|Bacteria H Involved in molybdopterin and thiamine biosynthesis, family 2 moeB - 2.7.7.73,2.7.7.80,2.8.1.11 ko:K03148,ko:K21029,ko:K21147 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - Rhodanese,ThiF k59_1388660_1 2340.JV46_07470 7.13e-32 119.0 COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria,1J6D1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes cpdA GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005488,GO:0005506,GO:0008081,GO:0008150,GO:0008198,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0042545,GO:0042578,GO:0043167,GO:0043169,GO:0045229,GO:0046872,GO:0046914,GO:0071554,GO:0071555,GO:0071840 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos k59_1598043_1 1906.SFRA_23725 6.35e-05 47.4 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase fadD1 - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1598043_2 1219084.AP014508_gene59 0.000622 45.8 COG1032@1|root,COG1032@2|Bacteria,2GCAG@200918|Thermotogae 200918|Thermotogae C Radical SAM domain protein - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_1296128_1 518766.Rmar_1647 1.31e-45 165.0 COG1757@1|root,COG1757@2|Bacteria,4NHP9@976|Bacteroidetes,1FIXG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Na H antiporter - - - - - - - - - - - - Na_H_antiporter k59_1078873_1 1120966.AUBU01000010_gene2874 7.7e-22 101.0 COG2234@1|root,COG2234@2|Bacteria,4NI5W@976|Bacteroidetes,47MK3@768503|Cytophagia 976|Bacteroidetes S glutamate carboxypeptidase - - 3.4.17.21 ko:K01301 - - - - ko00000,ko01000,ko01002 - - - PA,Peptidase_M28,TFR_dimer k59_1239589_1 589865.DaAHT2_2396 5.43e-61 201.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,42R3H@68525|delta/epsilon subdivisions,2WMNY@28221|Deltaproteobacteria,2MKRR@213118|Desulfobacterales 28221|Deltaproteobacteria D NUBPL iron-transfer P-loop NTPase - - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,CbiA,HTH_25,ParA k59_1598047_1 204669.Acid345_2625 1.03e-16 79.0 COG0524@1|root,COG0524@2|Bacteria,3Y3GE@57723|Acidobacteria,2JHP7@204432|Acidobacteriia 204432|Acidobacteriia G pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB k59_1598047_2 240015.ACP_3357 8.5e-31 117.0 COG0005@1|root,COG0005@2|Bacteria,3Y2MA@57723|Acidobacteria,2JI5Q@204432|Acidobacteriia 204432|Acidobacteriia F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates mtnP - 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_867490_1 1122137.AQXF01000002_gene480 9.66e-47 167.0 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,2U34G@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Mate efflux family protein - - - - - - - - - - - - MatE k59_1296150_2 1196322.A370_00418 2.6e-16 84.7 COG0476@1|root,COG0476@2|Bacteria,1VIBM@1239|Firmicutes,25GG8@186801|Clostridia,36WX5@31979|Clostridiaceae 186801|Clostridia H ThiF family - - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_605706_1 436308.Nmar_1466 3.27e-73 226.0 COG0367@1|root,arCOG00071@2157|Archaea,41SIX@651137|Thaumarchaeota 651137|Thaumarchaeota E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase k59_605706_2 65393.PCC7424_2924 7.24e-07 49.7 COG2154@1|root,COG2154@2|Bacteria,1G7P9@1117|Cyanobacteria,3KIJP@43988|Cyanothece 1117|Cyanobacteria H PFAM transcriptional coactivator pterin dehydratase phhB - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a k59_712745_1 991905.SL003B_4077 3.59e-38 139.0 COG2801@1|root,COG2801@2|Bacteria,1R7WH@1224|Proteobacteria,2VFQA@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_21,rve k59_1503734_1 177437.HRM2_48330 1.76e-76 233.0 COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,42QR5@68525|delta/epsilon subdivisions,2WMSR@28221|Deltaproteobacteria,2MJFW@213118|Desulfobacterales 28221|Deltaproteobacteria M Lipocalin-like domain - - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_1503741_1 253839.SSNG_01640 2.84e-06 45.8 2DSQW@1|root,33H3S@2|Bacteria,2GTIV@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_669234_1 1713.JOFV01000002_gene550 3.13e-12 71.6 COG1300@1|root,COG1300@2|Bacteria,2GJTG@201174|Actinobacteria,4F0H8@85016|Cellulomonadaceae 201174|Actinobacteria S Stage II sporulation protein M - - - - - - - - - - - - SpoIIM k59_1447272_2 9713.XP_006741929.1 2.94e-13 73.9 COG1262@1|root,2QVDG@2759|Eukaryota,38C17@33154|Opisthokonta,3B9T4@33208|Metazoa,3CX3Y@33213|Bilateria,4819N@7711|Chordata,48WT5@7742|Vertebrata,3JC51@40674|Mammalia,3ESW1@33554|Carnivora 33208|Metazoa S factor 1 SUMF1 GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005788,GO:0006464,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006687,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0012505,GO:0016491,GO:0016667,GO:0016670,GO:0018158,GO:0019538,GO:0031974,GO:0036211,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114,GO:0070013,GO:0071704,GO:0120147,GO:1901135,GO:1901564,GO:1903135,GO:1903509 1.8.3.7 ko:K13444 ko04142,map04142 - - - ko00000,ko00001,ko01000 - - - FGE-sulfatase k59_1296170_1 269798.CHU_1392 1.96e-57 200.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,4NIPS@976|Bacteroidetes,47M8S@768503|Cytophagia 976|Bacteroidetes E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_971349_1 981384.AEYW01000025_gene4045 7.11e-08 54.3 COG1073@1|root,COG1234@1|root,COG1073@2|Bacteria,COG1234@2|Bacteria 2|Bacteria L tRNA 3'-trailer cleavage - - 3.1.26.11,3.1.4.17 ko:K00784,ko:K01120 ko00230,ko03013,map00230,map03013 - R00191,R01234 RC00296 ko00000,ko00001,ko01000,ko03016 - - - Abhydrolase_1,Lactamase_B_2 k59_971349_2 1121403.AUCV01000009_gene1466 2.4e-23 93.6 2DKVG@1|root,30GRY@2|Bacteria,1RDQT@1224|Proteobacteria,42V8G@68525|delta/epsilon subdivisions,2WRP8@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Cytochrome P460 - - - - - - - - - - - - Cytochrome_P460 k59_347407_1 96561.Dole_0541 1.74e-19 83.6 COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,42TGQ@68525|delta/epsilon subdivisions,2WQ6R@28221|Deltaproteobacteria,2MK5K@213118|Desulfobacterales 28221|Deltaproteobacteria S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_347407_2 1499967.BAYZ01000082_gene1014 1.84e-10 60.5 COG0353@1|root,COG0353@2|Bacteria,2NP5N@2323|unclassified Bacteria 2|Bacteria L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - HHH,RecR,Toprim_4 k59_1023840_1 1056820.KB900632_gene2244 2.27e-22 97.4 COG3637@1|root,COG3637@2|Bacteria,1R3QN@1224|Proteobacteria,1RY3J@1236|Gammaproteobacteria,2PNSV@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_1131030_1 419947.MRA_2986 7.54e-09 57.0 COG3510@1|root,COG3510@2|Bacteria,2IAQB@201174|Actinobacteria,238FZ@1762|Mycobacteriaceae 201174|Actinobacteria V Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p-hydroxybenzoic acid derivatives (p-HBAD) - GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006029,GO:0006082,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0030166,GO:0030203,GO:0030204,GO:0030206,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044272,GO:0044281,GO:0044464,GO:0050650,GO:0050654,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903510 - - - - - - - - - - CmcI k59_1131030_2 1445613.JALM01000010_gene2414 7.11e-33 118.0 COG3631@1|root,COG3631@2|Bacteria,2IG87@201174|Actinobacteria,4E3F5@85010|Pseudonocardiales 201174|Actinobacteria S SnoaL-like domain - - 5.3.3.1 ko:K01822 ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120 M00107,M00110 R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955 RC00146,RC00762 ko00000,ko00001,ko00002,ko01000 - - - SnoaL_2 k59_1333256_1 880072.Desac_1429 5.42e-57 182.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2WJGN@28221|Deltaproteobacteria,2MRHQ@213462|Syntrophobacterales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_1177081_1 869210.Marky_1283 8.41e-127 401.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1WIA7@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E PFAM Conserved region in glutamate synthase - - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_140365_1 1177594.MIC448_1520004 3.49e-43 159.0 COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria,4FK4I@85023|Microbacteriaceae 201174|Actinobacteria G pfam00933, Glyco_hydro_3, Glycosyl hydrolase family 3 N terminal domain. pfam01915,Glyco_hydro_3_C, Glycosyl hydrolase family 3 C terminal domain bglX - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_1078975_1 1121403.AUCV01000019_gene3248 1.16e-13 65.1 COG0236@1|root,COG0236@2|Bacteria,1NHIC@1224|Proteobacteria,42X69@68525|delta/epsilon subdivisions,2WSMW@28221|Deltaproteobacteria,2MMFN@213118|Desulfobacterales 28221|Deltaproteobacteria IQ Phosphopantetheine attachment site - - - - - - - - - - - - PP-binding k59_1078975_2 177439.DP2405 9.37e-47 164.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,42NXM@68525|delta/epsilon subdivisions,2WJ2I@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q PFAM FAD dependent oxidoreductase - - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31,5.2.1.13 ko:K09835,ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 M00097 R04787,R04798,R04800,R07512,R09691,R09692 RC01214,RC01960,RC02088,RC02605 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_1023857_1 1232410.KI421425_gene1544 8.09e-51 166.0 COG0848@1|root,COG0848@2|Bacteria,1RENY@1224|Proteobacteria,42X3K@68525|delta/epsilon subdivisions,2WT0T@28221|Deltaproteobacteria,43V5B@69541|Desulfuromonadales 28221|Deltaproteobacteria U Biopolymer transport protein ExbD/TolR aglS - - - - - - - - - - - ExbD k59_295369_1 1249627.D779_1881 4.39e-129 395.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales 135613|Chromatiales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_1538522_1 45351.EDO37544 6.28e-34 133.0 COG0028@1|root,KOG1185@2759|Eukaryota,38EFU@33154|Opisthokonta,3BGF6@33208|Metazoa 33208|Metazoa EH thiamine pyrophosphate binding HACL1 GO:0001561,GO:0003674,GO:0003824,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006605,GO:0006625,GO:0006629,GO:0006631,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0015031,GO:0015833,GO:0016042,GO:0016043,GO:0016054,GO:0016829,GO:0016830,GO:0019395,GO:0019752,GO:0019842,GO:0022607,GO:0030258,GO:0030976,GO:0031907,GO:0031974,GO:0032787,GO:0033036,GO:0033365,GO:0034440,GO:0034613,GO:0036094,GO:0042579,GO:0042802,GO:0042886,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046395,GO:0046907,GO:0048037,GO:0050662,GO:0051179,GO:0051234,GO:0051259,GO:0051641,GO:0051649,GO:0055114,GO:0065003,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072329,GO:0072594,GO:0072662,GO:0072663,GO:0097159,GO:1901363,GO:1901575,GO:1901681 - ko:K12261 ko04146,map04146 - - - ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_669297_1 472759.Nhal_1234 3.82e-130 379.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1WW8H@135613|Chromatiales 135613|Chromatiales I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_1657149_2 439235.Dalk_1726 6.71e-76 239.0 COG1703@1|root,COG1703@2|Bacteria,1R44P@1224|Proteobacteria,43B1C@68525|delta/epsilon subdivisions,2X6FJ@28221|Deltaproteobacteria,2MPHZ@213118|Desulfobacterales 28221|Deltaproteobacteria E TIGRFAM LAO AO transport system ATPase - - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k59_712811_1 999541.bgla_2g13880 1.98e-65 219.0 COG0845@1|root,COG1994@1|root,COG0845@2|Bacteria,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,2VIUH@28216|Betaproteobacteria,1K379@119060|Burkholderiaceae 28216|Betaproteobacteria M membrane-associated Zn-dependent proteases 1 - - - ko:K16922 - - - - ko00000,ko01002 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1657154_1 1499967.BAYZ01000009_gene5392 5.33e-121 361.0 COG2719@1|root,COG2719@2|Bacteria 2|Bacteria S cellular response to DNA damage stimulus spoVR GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 - ko:K06415 - - - - ko00000 - - - SpoVR k59_140402_1 1249627.D779_4147 6.98e-55 178.0 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,1S3R2@1236|Gammaproteobacteria,1WXQD@135613|Chromatiales 135613|Chromatiales O once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran k59_15498_2 469383.Cwoe_4214 5.07e-24 99.8 COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria 201174|Actinobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit - - 6.2.1.18 ko:K15232 ko00720,ko01100,ko01120,ko01200,map00720,map01100,map01120,map01200 M00173 R01322 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2 k59_922516_1 935863.AWZR01000005_gene2252 4.39e-06 51.6 COG0517@1|root,COG0517@2|Bacteria,1N68U@1224|Proteobacteria,1SYB9@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_669333_2 472759.Nhal_3796 2.62e-16 75.1 COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,1S9AB@1236|Gammaproteobacteria,1WYTV@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0235 family - - - ko:K09131 - - - - ko00000 - - - DUF167 k59_669333_3 1121035.AUCH01000009_gene792 5.56e-12 64.7 COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,2VVGB@28216|Betaproteobacteria,2M02C@206389|Rhodocyclales 206389|Rhodocyclales S YGGT family - - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_826476_1 500637.PROVRUST_08140 1.15e-26 101.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,3Z8ZQ@586|Providencia 1236|Gammaproteobacteria J translation initiation inhibitor, yjgF family - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_762492_1 472759.Nhal_2537 2.39e-70 227.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1WWB1@135613|Chromatiales 135613|Chromatiales T SMART Nucleotide binding protein, PINc - - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_15520_1 1229909.NSED_08175 2.53e-80 242.0 arCOG08639@1|root,arCOG08639@2157|Archaea,41SP8@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1177143_1 990285.RGCCGE502_12299 7.14e-10 62.4 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2U787@28211|Alphaproteobacteria,4B876@82115|Rhizobiaceae 28211|Alphaproteobacteria M Belongs to the ompA family yiaD - - - - - - - - - - - Gly-zipper_Omp,Gly-zipper_YMGG,OmpA k59_102941_1 1411123.JQNH01000001_gene3809 6.77e-180 512.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family bioA - 2.6.1.18 ko:K00822 ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100 - R00907,R04187 RC00008,RC00062,RC00160 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_931415_1 595460.RRSWK_02125 1.26e-11 70.1 COG1357@1|root,COG1511@1|root,COG2931@1|root,COG3291@1|root,COG1357@2|Bacteria,COG1511@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,2IZ0P@203682|Planctomycetes 203682|Planctomycetes Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HemolysinCabind,Laminin_G_3 k59_562090_1 32057.KB217478_gene6658 4.25e-11 63.2 COG0399@1|root,COG0399@2|Bacteria,1G0IM@1117|Cyanobacteria 1117|Cyanobacteria E Belongs to the DegT DnrJ EryC1 family degT - - - - - - - - - - - DegT_DnrJ_EryC1 k59_562090_2 448385.sce5461 1.41e-16 81.3 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42R6N@68525|delta/epsilon subdivisions,2WKF4@28221|Deltaproteobacteria,2Z2XV@29|Myxococcales 28221|Deltaproteobacteria H High confidence in function and specificity - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_304374_1 1335757.SPICUR_06165 2.29e-05 52.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1WWPS@135613|Chromatiales 135613|Chromatiales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_304374_2 35841.BT1A1_2166 3.13e-05 44.7 COG1722@1|root,COG1722@2|Bacteria,1VK9I@1239|Firmicutes,4HNRB@91061|Bacilli,1ZIVS@1386|Bacillus 91061|Bacilli L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S k59_1087799_1 592015.HMPREF1705_01970 3.45e-39 144.0 COG0845@1|root,COG0845@2|Bacteria,3T9UB@508458|Synergistetes 508458|Synergistetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_613900_1 1117647.M5M_08255 4.43e-38 142.0 COG0845@1|root,COG0845@2|Bacteria,1R4JA@1224|Proteobacteria,1RPS5@1236|Gammaproteobacteria,1J60K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1546730_1 1123368.AUIS01000003_gene1618 3.37e-74 229.0 COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,2NC81@225057|Acidithiobacillales 225057|Acidithiobacillales O Glutathione S-transferase, C-terminal domain - - - ko:K03599 - - - - ko00000,ko02000,ko03021 1.A.12.3.1 - - GST_C,GST_C_2,GST_N_3 k59_1546730_2 1101195.Meth11DRAFT_0352 1.27e-24 98.6 COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,2VSGG@28216|Betaproteobacteria,2KMYV@206350|Nitrosomonadales 206350|Nitrosomonadales S PFAM Stringent starvation protein B - - - ko:K03600 - - - - ko00000,ko03021 - - - SspB k59_1546730_3 1519439.JPJG01000078_gene911 1.08e-11 65.1 COG2110@1|root,COG2110@2|Bacteria,1TPCU@1239|Firmicutes,24ARG@186801|Clostridia,2N7GX@216572|Oscillospiraceae 186801|Clostridia S Macro domain - - - - - - - - - - - - Macro k59_1184289_1 46234.ANA_C13221 3.22e-10 66.6 COG0863@1|root,COG0863@2|Bacteria,1G911@1117|Cyanobacteria,1HJ75@1161|Nostocales 1117|Cyanobacteria H DNA methylase - - 2.1.1.113 ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_1546743_1 80637.XP_007763271.1 1.83e-37 133.0 COG0288@1|root,2RXIV@2759|Eukaryota,3A0V8@33154|Opisthokonta,3P2JY@4751|Fungi,3V2M5@5204|Basidiomycota,229FG@155619|Agaricomycetes 4751|Fungi G Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_1454563_1 1313172.YM304_31080 1.51e-26 115.0 COG1020@1|root,COG1020@2|Bacteria,2GKU0@201174|Actinobacteria 201174|Actinobacteria Q diacylglycerol O-acyltransferase - GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - DUF1298,WES_acyltransf k59_770650_1 713586.KB900536_gene1008 2.26e-39 137.0 2CARE@1|root,2Z8Q5@2|Bacteria,1R7S8@1224|Proteobacteria,1RRAH@1236|Gammaproteobacteria,1WW2H@135613|Chromatiales 135613|Chromatiales S TIGRFAM CRISPR-associated protein - - - - - - - - - - - - Cas6 k59_522215_1 1237149.C900_03947 1.02e-12 68.2 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47JJN@768503|Cytophagia 976|Bacteroidetes V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1032290_1 713586.KB900536_gene633 1.49e-26 100.0 2ECSY@1|root,336QI@2|Bacteria,1N9AZ@1224|Proteobacteria,1S9XM@1236|Gammaproteobacteria,1WYWD@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_1032290_2 879212.DespoDRAFT_01964 4.15e-09 60.8 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42PWS@68525|delta/epsilon subdivisions,2WKI5@28221|Deltaproteobacteria,2MJ8W@213118|Desulfobacterales 28221|Deltaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_931458_1 314278.NB231_10053 2.28e-19 88.6 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1WXKV@135613|Chromatiales 135613|Chromatiales M peptidase M48, Ste24p - - - - - - - - - - - - Peptidase_M48 k59_1454576_1 584708.Apau_1036 3.73e-68 225.0 COG0018@1|root,COG0018@2|Bacteria,3TA5K@508458|Synergistetes 508458|Synergistetes J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_249197_1 452637.Oter_2702 4.78e-71 228.0 COG1092@1|root,COG1092@2|Bacteria,46SJ5@74201|Verrucomicrobia,3K84I@414999|Opitutae 414999|Opitutae J S-adenosylmethionine-dependent methyltransferase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_102998_1 1479238.JQMZ01000001_gene1914 6.76e-20 94.7 COG5360@1|root,COG5360@2|Bacteria,1MUJ4@1224|Proteobacteria,2U48V@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Heparinase II/III N-terminus - - - - - - - - - - - - Hepar_II_III,Hepar_II_III_N k59_1087842_1 331869.BAL199_06599 2.27e-74 234.0 COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG1960 Acyl-CoA dehydrogenases - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1087842_2 1458357.BG58_21650 4.74e-29 110.0 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,1K3K2@119060|Burkholderiaceae 28216|Betaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_461730_2 713586.KB900536_gene1936 2.38e-70 222.0 2FAJB@1|root,342T9@2|Bacteria,1NXTF@1224|Proteobacteria,1SQ2S@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1395952_1 983545.Glaag_1818 2.35e-23 99.8 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,1RN46@1236|Gammaproteobacteria,4644Z@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_148297_1 671143.DAMO_0988 5.55e-05 45.8 COG1499@1|root,COG1499@2|Bacteria,2NS26@2323|unclassified Bacteria 2|Bacteria J ribosomal large subunit export from nucleus - - - - - - - - - - - - NMD3 k59_148297_2 56780.SYN_01247 1.15e-33 118.0 2DCXT@1|root,2ZFR8@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_249212_1 1122604.JONR01000018_gene1121 1.94e-61 202.0 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1X71M@135614|Xanthomonadales 135614|Xanthomonadales PT Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - Rhodanese,cNMP_binding k59_522265_1 330214.NIDE4326 4.19e-21 92.8 2CK1C@1|root,32SJA@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1604656_1 555778.Hneap_1444 3.82e-33 127.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1WWER@135613|Chromatiales 135613|Chromatiales M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_148303_1 228410.NE1298 7.52e-24 104.0 COG0457@1|root,COG3712@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,1RJUD@1224|Proteobacteria,2WBAA@28216|Betaproteobacteria,372PS@32003|Nitrosomonadales 28216|Betaproteobacteria PT TonB-dependent receptor, beta-barrel - - - - - - - - - - - - FecR,TPR_8,TonB_dep_Rec k59_1669191_1 1479238.JQMZ01000001_gene1038 0.000124 44.7 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TR32@28211|Alphaproteobacteria,43W9H@69657|Hyphomonadaceae 28211|Alphaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1669191_2 861299.J421_3267 2.86e-38 140.0 COG1060@1|root,COG1060@2|Bacteria,1ZSRJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Elongator protein 3, MiaB family, Radical SAM - - 2.5.1.120 ko:K18285 ko00130,ko01110,map00130,map01110 - R10667 RC00021,RC03234 ko00000,ko00001,ko01000 - - - Radical_SAM k59_103024_1 1454004.AW11_03694 2.92e-55 191.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,1KQJM@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P Oligopeptide/dipeptide transporter, C-terminal region dppF - - ko:K02031,ko:K02032,ko:K13896 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - ABC_tran,oligo_HPY k59_19147_1 1367847.JCM7686_1311 9.19e-14 72.0 COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2UBUR@28211|Alphaproteobacteria,2PUT1@265|Paracoccus 28211|Alphaproteobacteria S Copper chaperone PCu(A)C - - - ko:K09796 - - - - ko00000,ko03110 - - - PCuAC k59_875870_1 1279019.ARQK01000045_gene544 2.38e-20 93.6 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WW1B@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1454617_1 1231391.AMZF01000110_gene851 1.52e-38 144.0 COG2175@1|root,COG2175@2|Bacteria,1Q0C7@1224|Proteobacteria,2VQEW@28216|Betaproteobacteria,3T3V5@506|Alcaligenaceae 28216|Betaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_1247546_1 429009.Adeg_1597 1.42e-96 302.0 COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia 186801|Clostridia I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_461780_1 192952.MM_1711 1.24e-53 179.0 COG0053@1|root,arCOG01474@2157|Archaea,2XU96@28890|Euryarchaeota,2N9HJ@224756|Methanomicrobia 224756|Methanomicrobia P Dimerisation domain of Zinc Transporter - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_522317_1 436308.Nmar_0672 7.67e-107 315.0 COG0492@1|root,arCOG01296@2157|Archaea,41S97@651137|Thaumarchaeota 651137|Thaumarchaeota O Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_931525_1 666685.R2APBS1_0332 8.57e-185 547.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1X4KE@135614|Xanthomonadales 135614|Xanthomonadales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_614020_1 935863.AWZR01000003_gene2732 1.08e-39 145.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1X3ED@135614|Xanthomonadales 135614|Xanthomonadales C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_1454642_1 688270.Celal_2955 7.63e-32 115.0 COG0599@1|root,COG0599@2|Bacteria,4NYAJ@976|Bacteroidetes,1I9PN@117743|Flavobacteriia 976|Bacteroidetes S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_1396030_2 1538295.JY96_07675 1.38e-15 75.5 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2VHAW@28216|Betaproteobacteria,1KJJY@119065|unclassified Burkholderiales 28216|Betaproteobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase glxR GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006573,GO:0006574,GO:0006807,GO:0008150,GO:0008152,GO:0008442,GO:0009056,GO:0009063,GO:0009081,GO:0009083,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_356506_1 991905.SL003B_2007 5.1e-67 219.0 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2TR9C@28211|Alphaproteobacteria,4BPRV@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family - - - ko:K09971 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_721397_2 469382.Hbor_05170 2.02e-05 50.8 COG3949@1|root,arCOG00505@2157|Archaea,2XT7W@28890|Euryarchaeota,23TF6@183963|Halobacteria 183963|Halobacteria S COG0491 Zn-dependent hydrolases, including glyoxylases - - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B k59_1248640_1 315749.Bcer98_3195 1.32e-21 98.2 COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,1ZB3S@1386|Bacillus 91061|Bacilli Q Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP- dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,KR,PP-binding,Thioesterase,adh_short k59_408466_2 326297.Sama_3589 1.15e-05 50.8 COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,1RP16@1236|Gammaproteobacteria,2QAG0@267890|Shewanellaceae 1236|Gammaproteobacteria M HlyD family secretion protein - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3 k59_1455805_1 760192.Halhy_2259 4.85e-30 124.0 COG4584@1|root,COG4584@2|Bacteria,4NEY6@976|Bacteroidetes,1IPYU@117747|Sphingobacteriia 976|Bacteroidetes L PFAM Integrase, catalytic core - - - - - - - - - - - - rve k59_932872_1 330214.NIDE3752 2.3e-58 191.0 COG0530@1|root,COG0530@2|Bacteria 2|Bacteria P calcium, potassium:sodium antiporter activity yrbG - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_563434_1 869213.JCM21142_41816 2.08e-79 245.0 COG2086@1|root,COG2086@2|Bacteria,4NFWB@976|Bacteroidetes 976|Bacteroidetes C Electron transfer flavoprotein etfB - - ko:K03521 - - - - ko00000 - - - ETF k59_722615_1 1192034.CAP_4132 5.35e-54 191.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,42MP3@68525|delta/epsilon subdivisions,2WJ7Y@28221|Deltaproteobacteria,2YX41@29|Myxococcales 28221|Deltaproteobacteria O Protein of unknown function, DUF255 yyaL - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_932874_1 535289.Dtpsy_2193 5.79e-91 271.0 COG2020@1|root,COG2020@2|Bacteria,1MUBZ@1224|Proteobacteria,2VJJ4@28216|Betaproteobacteria,4AH63@80864|Comamonadaceae 28216|Betaproteobacteria O NnrU protein - - - - - - - - - - - - ICMT,PEMT k59_722617_1 436308.Nmar_1334 8.06e-60 188.0 COG0589@1|root,arCOG02053@2157|Archaea 2157|Archaea T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - 2.7.13.3 ko:K07646 ko02020,map02020 M00454 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF4118,GAF_3,KdpD,Usp k59_19701_1 457415.HMPREF1006_02529 1.22e-19 96.7 COG0168@1|root,COG0168@2|Bacteria,3T9WI@508458|Synergistetes 508458|Synergistetes P Potassium uptake protein, TrkH family - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_149453_1 477228.YO5_14046 9.31e-20 93.2 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,1Z229@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C acyl-CoA transferases carnitine dehydratase - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_877131_1 1366050.N234_12300 4.92e-10 63.2 COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2VHBT@28216|Betaproteobacteria,1K4NQ@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - TPR_19,TPR_8,Trans_reg_C k59_1248682_1 1313172.YM304_17130 1.96e-65 206.0 COG1028@1|root,COG1028@2|Bacteria,2GNM4@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_1141616_1 697284.ERIC2_c02280 9.91e-74 234.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,4HAMQ@91061|Bacilli,26QZ9@186822|Paenibacillaceae 91061|Bacilli P Belongs to the ABC transporter superfamily msmX - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE,TOBE_2 k59_1566144_1 243231.GSU2502 1.38e-15 83.6 COG0421@1|root,COG0421@2|Bacteria,1QX98@1224|Proteobacteria,43C2D@68525|delta/epsilon subdivisions,2X7CZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_1200589_1 414684.RC1_0877 1.11e-50 179.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria,2JPVV@204441|Rhodospirillales 204441|Rhodospirillales E Transglutaminase/protease-like homologues - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_1200589_2 519989.ECTPHS_10536 2.23e-51 174.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1WXDA@135613|Chromatiales 135613|Chromatiales S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_1566234_1 331869.BAL199_22467 1.6e-68 225.0 COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2TVJ9@28211|Alphaproteobacteria,4BT9Y@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1200630_1 1173027.Mic7113_3072 4.02e-32 128.0 COG0068@1|root,COG0068@2|Bacteria,1G063@1117|Cyanobacteria,1H71F@1150|Oscillatoriales 1117|Cyanobacteria O Belongs to the carbamoyltransferase HypF family hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_1356593_1 443152.MDG893_14258 4.52e-64 214.0 COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,1RQ3I@1236|Gammaproteobacteria,469CS@72275|Alteromonadaceae 1236|Gammaproteobacteria Q 4-hydroxyphenylacetate 3-hydroxylase C terminal hpaB - 1.14.14.9 ko:K00483 ko00350,ko01120,ko01220,map00350,map01120,map01220 - R02698,R03299 RC00046 ko00000,ko00001,ko01000 - - iB21_1397.B21_04188,iECBD_1354.ECBD_3674,iECD_1391.ECD_04222,iSF_1195.SF4375,iSbBS512_1146.SbBS512_E4882 HpaB,HpaB_N k59_1356595_1 1229909.NSED_01215 3.29e-89 275.0 COG0165@1|root,arCOG01748@2157|Archaea,41S6A@651137|Thaumarchaeota 651137|Thaumarchaeota E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_1200694_1 1123399.AQVE01000004_gene2626 7.56e-48 168.0 COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,1RMDQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria KLT serine threonine protein kinase pkn3 - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - Pkinase k59_1566369_1 94624.Bpet1218 2.76e-56 191.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VIE2@28216|Betaproteobacteria 28216|Betaproteobacteria G C4-dicarboxylate transport system - - - - - - - - - - - - DctM k59_25655_1 452637.Oter_0322 8.58e-33 127.0 COG0845@1|root,COG0845@2|Bacteria,46TJP@74201|Verrucomicrobia,3K7D1@414999|Opitutae 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1200800_1 1250232.JQNJ01000001_gene3216 1.25e-35 132.0 COG3000@1|root,COG3000@2|Bacteria,4NI62@976|Bacteroidetes,1I9FZ@117743|Flavobacteriia 976|Bacteroidetes I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_1566560_1 479434.Sthe_1507 2.95e-55 187.0 COG0477@1|root,COG2814@2|Bacteria,2G8DX@200795|Chloroflexi 200795|Chloroflexi EGP PFAM major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_1 k59_1616187_1 941449.dsx2_3289 9.57e-97 291.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,42MSF@68525|delta/epsilon subdivisions,2WKJ5@28221|Deltaproteobacteria,2M87G@213115|Desulfovibrionales 28221|Deltaproteobacteria C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - iAF987.Gmet_1099 AlaDh_PNT_C,AlaDh_PNT_N k59_1616211_1 1379698.RBG1_1C00001G0025 1.62e-49 167.0 COG1005@1|root,COG1005@2|Bacteria,2NQIK@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 ko:K00337,ko:K05572 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_1616211_2 1232410.KI421419_gene2543 3.6e-13 71.2 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,42R5T@68525|delta/epsilon subdivisions,2WMVQ@28221|Deltaproteobacteria,43TKQ@69541|Desulfuromonadales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_1566817_1 1205680.CAKO01000037_gene1352 3.19e-66 214.0 COG4948@1|root,COG4948@2|Bacteria,1MVFW@1224|Proteobacteria,2TU7R@28211|Alphaproteobacteria,2JQRD@204441|Rhodospirillales 204441|Rhodospirillales M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_1566860_1 512565.AMIS_21760 2.5e-20 93.6 COG1028@1|root,COG1028@2|Bacteria,2GN6U@201174|Actinobacteria,4D90C@85008|Micromonosporales 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short,adh_short_C2 k59_1356964_1 998674.ATTE01000001_gene2168 7.03e-60 204.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,45ZN8@72273|Thiotrichales 72273|Thiotrichales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_1566868_1 1469245.JFBG01000097_gene1352 7.79e-108 337.0 COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,1RP0M@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the dehydration of galactarate to form 5- dehydro-4-deoxy-D-glucarate garD GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008867,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0071704,GO:1901575 4.2.1.42,4.2.1.7 ko:K01685,ko:K01708 ko00040,ko00053,ko01100,map00040,map00053,map01100 M00631 R01540,R05608 RC00543 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_3790,iECP_1309.ECP_3218,iLF82_1304.LF82_0803,iNRG857_1313.NRG857_15535 GD_AH_C,SAF k59_25802_1 1249627.D779_0942 6.42e-141 425.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1WW2Y@135613|Chromatiales 135613|Chromatiales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_1357102_1 1049564.TevJSym_af00100 4.45e-56 182.0 296ZZ@1|root,2ZU8H@2|Bacteria,1RED2@1224|Proteobacteria,1S5WC@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1201151_1 526225.Gobs_1840 2.17e-59 202.0 COG2072@1|root,COG2072@2|Bacteria,2GKYU@201174|Actinobacteria,4EUFR@85013|Frankiales 201174|Actinobacteria P Flavin-binding monooxygenase-like - - - - - - - - - - - - FMO-like k59_25857_1 204669.Acid345_4062 9.07e-08 52.4 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator - - - - - - - - - - - - Response_reg k59_25857_2 573413.Spirs_3405 6.13e-07 53.5 COG0835@1|root,COG0835@2|Bacteria 2|Bacteria NT chemotaxis MA20_10415 - - ko:K03408,ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW k59_1357123_1 1443125.Z962_04445 2.14e-06 56.2 COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,248XQ@186801|Clostridia,36H58@31979|Clostridiaceae 186801|Clostridia S Oxidoreductase family, C-terminal alpha/beta domain - - 1.1.1.18,1.1.1.369 ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 - R01183,R09951 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_1616387_1 395493.BegalDRAFT_1528 4.77e-86 268.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,4605B@72273|Thiotrichales 72273|Thiotrichales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_1201227_2 1121937.AUHJ01000004_gene1006 3.47e-65 204.0 COG3631@1|root,COG3631@2|Bacteria,1QZVS@1224|Proteobacteria,1T5IJ@1236|Gammaproteobacteria,46A51@72275|Alteromonadaceae 1236|Gammaproteobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_1201237_1 1265313.HRUBRA_00658 1.33e-76 248.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1J4HD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Heat shock 70 kDa protein dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1357198_1 519989.ECTPHS_03212 7.89e-61 194.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,1WXR9@135613|Chromatiales 135613|Chromatiales IQ PFAM Short-chain dehydrogenase reductase SDR fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1201286_1 1424334.W822_03750 4.35e-94 285.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VHBI@28216|Betaproteobacteria,3T36A@506|Alcaligenaceae 28216|Betaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_25935_1 502025.Hoch_5783 1.44e-127 375.0 COG2170@1|root,COG2170@2|Bacteria,1MY35@1224|Proteobacteria,42PBG@68525|delta/epsilon subdivisions,2WK4S@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Glutamate-cysteine ligase - - - - - - - - - - - - GCS2 k59_1201310_1 1122201.AUAZ01000009_gene2845 2.68e-74 233.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1RNQ4@1236|Gammaproteobacteria,4644Q@72275|Alteromonadaceae 1236|Gammaproteobacteria C Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily adhC - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1616506_1 338963.Pcar_2171 1.24e-43 162.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,43T20@69541|Desulfuromonadales 28221|Deltaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1616577_1 1038862.KB893805_gene3645 2.73e-43 160.0 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_26028_1 1504672.669786861 2.21e-69 234.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,4AAN3@80864|Comamonadaceae 28216|Betaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_1357489_1 448385.sce7469 1.3e-09 58.5 COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1R66T@1224|Proteobacteria 1224|Proteobacteria C amine dehydrogenase activity - - - - - - - - - - - - Lactonase k59_1616721_1 349521.HCH_02985 5.48e-17 85.1 COG2273@1|root,COG3568@1|root,COG2273@2|Bacteria,COG3568@2|Bacteria,1QZA0@1224|Proteobacteria,1T42V@1236|Gammaproteobacteria,1XQJT@135619|Oceanospirillales 2|Bacteria G Cellulose Binding Domain Type IV - - - - - - - - - - - - Big_2,CBM_4_9,CBM_6,DHOR,Exo_endo_phos,F5_F8_type_C,FIVAR,Glyco_hydro_16,TSP_3 k59_26058_1 1144275.COCOR_03439 4.43e-45 155.0 COG3293@1|root,COG3293@2|Bacteria,1P5HD@1224|Proteobacteria,42TZG@68525|delta/epsilon subdivisions,2WQT4@28221|Deltaproteobacteria 28221|Deltaproteobacteria L manually curated - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_1357523_1 450851.PHZ_c2499 6.77e-91 280.0 COG1960@1|root,COG1960@2|Bacteria,1P8I7@1224|Proteobacteria,2U0AW@28211|Alphaproteobacteria,2KHVE@204458|Caulobacterales 204458|Caulobacterales C Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1616736_1 381666.H16_A0559 9.2e-15 78.6 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,2VHHX@28216|Betaproteobacteria,1K2BX@119060|Burkholderiaceae 28216|Betaproteobacteria M heptosyltransferase II rfaF - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_1357543_1 472759.Nhal_1306 1.39e-119 357.0 COG1213@1|root,COG2513@1|root,COG1213@2|Bacteria,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,1RY5Q@1236|Gammaproteobacteria,1X09Q@135613|Chromatiales 135613|Chromatiales C Phosphoenolpyruvate phosphomutase - - 5.4.2.9 ko:K01841 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 - R00661 RC02792 ko00000,ko00001,ko01000 - - - NTP_transf_3,PEP_mutase k59_51880_2 179408.Osc7112_1046 2.1e-18 80.9 COG5331@1|root,COG5331@2|Bacteria,1G765@1117|Cyanobacteria,1HFFY@1150|Oscillatoriales 1117|Cyanobacteria S MAPEG family - - - - - - - - - - - - MAPEG k59_51886_1 436308.Nmar_0680 3.53e-90 270.0 COG2897@1|root,arCOG02019@2157|Archaea,41SBN@651137|Thaumarchaeota 651137|Thaumarchaeota P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_51980_1 1249627.D779_0882 1.34e-99 302.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1WVZ2@135613|Chromatiales 135613|Chromatiales E TIGRFAM glutamine synthetase, type I glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_51998_1 1121033.AUCF01000001_gene2286 2.32e-19 89.0 COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,2TSN7@28211|Alphaproteobacteria,2JPCS@204441|Rhodospirillales 204441|Rhodospirillales S Transport and Golgi organisation 2 - - - - - - - - - - - - TANGO2 k59_52059_1 395493.BegalDRAFT_3125 4.8e-99 302.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,1RPTT@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the binding-protein-dependent transport system permease family livM GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - iPC815.YPO3806,iSDY_1059.SDY_3605 BPD_transp_2,DUF3382 k59_52060_1 488538.SAR116_1471 1.3e-50 169.0 COG0715@1|root,COG0715@2|Bacteria 2|Bacteria P thiamine-containing compound biosynthetic process - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_52225_1 391625.PPSIR1_34807 4.31e-42 153.0 COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria,4379P@68525|delta/epsilon subdivisions,2X9XU@28221|Deltaproteobacteria,2Z1Y1@29|Myxococcales 28221|Deltaproteobacteria S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_104905_1 349102.Rsph17025_2442 4.31e-67 216.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria,1FBFW@1060|Rhodobacter 28211|Alphaproteobacteria C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_157076_1 1090319.KE386571_gene1449 3.21e-73 231.0 COG2141@1|root,COG2141@2|Bacteria,1MWMV@1224|Proteobacteria,2TTIQ@28211|Alphaproteobacteria,2K0FP@204457|Sphingomonadales 204457|Sphingomonadales C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - 1.14.14.5 ko:K04091 ko00920,map00920 - R07210,R10206 RC01779,RC02556 ko00000,ko00001,ko01000 - - - Bac_luciferase k59_679680_1 237368.SCABRO_04028 3.6e-75 241.0 COG0644@1|root,COG0664@1|root,COG0644@2|Bacteria,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding prnA - 1.14.19.9 ko:K07058,ko:K14266 ko00404,ko01130,map00404,map01130 M00789,M00790 R09570 RC00949 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_5,Trp_halogenase,cNMP_binding k59_731763_2 1049564.TevJSym_bo00170 9.71e-26 100.0 COG2010@1|root,COG2010@2|Bacteria,1N73U@1224|Proteobacteria,1SFGZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c nirC - - ko:K19344 - - - - ko00000 - - - Cytochrome_CBB3 k59_52825_1 1033802.SSPSH_001329 4.12e-10 64.7 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,1RMGB@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008955,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_611_1 166318.Syn8016DRAFT_1773 9.97e-37 140.0 COG0591@1|root,COG0591@2|Bacteria,1G3QJ@1117|Cyanobacteria,1GZ75@1129|Synechococcus 1117|Cyanobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1619748_2 1229909.NSED_06930 1.44e-33 115.0 COG2093@1|root,arCOG04077@2157|Archaea,41SVE@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcription elongation factor Spt4 spt4 - 2.7.7.6 ko:K03050 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - Spt4 k59_1619748_3 436308.Nmar_1237 1.07e-09 58.2 COG0157@1|root,arCOG01482@2157|Archaea,41SHI@651137|Thaumarchaeota 651137|Thaumarchaeota H Involved in the catabolism of quinolinic acid (QA) - - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_522810_2 220664.PFL_4269 0.000126 47.8 COG0589@1|root,COG0589@2|Bacteria,1N9QR@1224|Proteobacteria,1SDZX@1236|Gammaproteobacteria,1YNDA@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria T Universal stress protein - - - - - - - - - - - - Usp k59_1202012_1 1439940.BAY1663_03467 6.51e-12 63.5 2ENKU@1|root,33G87@2|Bacteria,1NMH6@1224|Proteobacteria,1SGDI@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_784126_1 1235457.C404_21910 3.44e-15 75.1 COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,2VI5F@28216|Betaproteobacteria,1K0NV@119060|Burkholderiaceae 28216|Betaproteobacteria M cyclopropane-fatty-acyl-phospholipid synthase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_784126_2 517418.Ctha_1642 9.62e-43 149.0 COG1723@1|root,COG1723@2|Bacteria 2|Bacteria S PFAM Uncharacterised ACR, YagE family COG1723 yagE - - - - - - - - - - - DUF155 k59_1463093_1 321327.CYA_0718 1.1e-60 191.0 COG0757@1|root,COG0757@2|Bacteria,1G5X4@1117|Cyanobacteria,1H0NE@1129|Synechococcus 1117|Cyanobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_261686_1 381666.H16_A3464 3.8e-32 122.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2VHQH@28216|Betaproteobacteria,1K42U@119060|Burkholderiaceae 28216|Betaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_1045202_1 1120956.JHZK01000039_gene3119 5.79e-05 44.7 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TU6H@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01692,ko:K01715 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1045202_2 1121374.KB891575_gene1051 9.64e-117 345.0 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,1RRVQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short,adh_short_C2 k59_157094_2 999141.GME_08579 1.2e-09 61.6 COG0730@1|root,COG0730@2|Bacteria,1MVY3@1224|Proteobacteria,1S21M@1236|Gammaproteobacteria,1XK5F@135619|Oceanospirillales 135619|Oceanospirillales S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_1463100_1 436308.Nmar_0882 2.61e-138 400.0 COG1503@1|root,arCOG01742@2157|Archaea,41SEK@651137|Thaumarchaeota 651137|Thaumarchaeota J Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA prf1 - - ko:K03265 ko03015,map03015 - - - ko00000,ko00001,ko03012,ko03019 - - - eRF1_1,eRF1_2,eRF1_3 k59_522822_1 1380394.JADL01000011_gene3917 1.37e-198 558.0 COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2TU3A@28211|Alphaproteobacteria,2JZFV@204441|Rhodospirillales 204441|Rhodospirillales M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_1463104_1 1265490.JHVY01000034_gene988 6.21e-27 111.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1254172_1 1123376.AUIU01000011_gene867 3.11e-60 207.0 COG1067@1|root,COG1067@2|Bacteria,3J0X2@40117|Nitrospirae 40117|Nitrospirae O AAA domain - - - - - - - - - - - - AAA_32,Lon_C k59_1588704_1 1191523.MROS_0858 2.7e-105 321.0 COG0508@1|root,COG0508@2|Bacteria 2|Bacteria C S-acyltransferase activity aceF GO:0003674,GO:0003824,GO:0004742,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016407,GO:0016417,GO:0016418,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030523,GO:0031405,GO:0031406,GO:0032787,GO:0032991,GO:0033293,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1902494,GO:1990204 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - iETEC_1333.ETEC_0111,iSSON_1240.SSON_0123,iYL1228.KPN_00119 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1643269_1 172088.AUGA01000004_gene3858 9.41e-38 142.0 COG2114@1|root,COG2114@2|Bacteria,1MVZU@1224|Proteobacteria,2U128@28211|Alphaproteobacteria,3JT5W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain cyaB - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc k59_1282525_1 1469245.JFBG01000023_gene1254 9.93e-11 63.5 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales 135613|Chromatiales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1282525_2 156578.ATW7_02782 1.67e-09 59.3 COG0652@1|root,COG0652@2|Bacteria,1RCXX@1224|Proteobacteria,1S3ZN@1236|Gammaproteobacteria 1236|Gammaproteobacteria M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K03767 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_1529880_1 398527.Bphyt_2728 6.98e-36 132.0 COG1028@1|root,COG1028@2|Bacteria,1PFUB@1224|Proteobacteria,2VK16@28216|Betaproteobacteria,1K64U@119060|Burkholderiaceae 28216|Betaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - ko:K13774 ko00281,map00281 - R08087,R08096,R10125,R10126 RC00080,RC00087 ko00000,ko00001 - - - adh_short_C2 k59_1324447_1 1116472.MGMO_41c00630 4.25e-95 302.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1XEQK@135618|Methylococcales 135618|Methylococcales O Cytochrome c-type biogenesis protein CcmF ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_1324447_2 1163617.SCD_n02734 2.03e-72 223.0 COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2VR8D@28216|Betaproteobacteria 28216|Betaproteobacteria CO Periplasmic protein thiol dsbE - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA,Redoxin k59_1324447_3 323261.Noc_0941 2.42e-09 56.6 COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,1S9DV@1236|Gammaproteobacteria,1WY4S@135613|Chromatiales 135613|Chromatiales P subunit of a heme lyase - - - ko:K02200 - - - - ko00000 - - - CcmH k59_752928_2 1313172.YM304_11800 7.01e-15 77.0 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4CNMY@84992|Acidimicrobiia 84992|Acidimicrobiia J Amidase - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_812592_1 690850.Desaf_2693 1.2e-07 55.8 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,42MBR@68525|delta/epsilon subdivisions,2WJ0Z@28221|Deltaproteobacteria,2M953@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM peptidase M48 Ste24p - - - - - - - - - - - iAF987.Gmet_1238 Peptidase_M48,TPR_14,TPR_16,TPR_19 k59_812592_2 118163.Ple7327_0024 2.88e-08 58.9 COG0546@1|root,COG2074@1|root,COG0546@2|Bacteria,COG2074@2|Bacteria,1GHAA@1117|Cyanobacteria,3VMG3@52604|Pleurocapsales 1117|Cyanobacteria G phosphoglycolate phosphatase activity - - - - - - - - - - - - - k59_1168793_1 1217720.ALOX01000032_gene283 7.16e-05 47.4 COG5350@1|root,COG5350@2|Bacteria,1RB7D@1224|Proteobacteria,2U59N@28211|Alphaproteobacteria,2JT44@204441|Rhodospirillales 204441|Rhodospirillales S Protein tyrosine phosphatase - - - - - - - - - - - - DSPc k59_1380506_1 686578.AFFX01000003_gene427 1.6e-126 376.0 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria 1236|Gammaproteobacteria O COG0464 ATPases of the AAA class - - - - - - - - - - - - AAA k59_1283781_1 582402.Hbal_1852 3.2e-50 175.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2TQPS@28211|Alphaproteobacteria,43W87@69657|Hyphomonadaceae 28211|Alphaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042,ko:K11528 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_1325170_1 105559.Nwat_0540 1.93e-104 316.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1WWJH@135613|Chromatiales 135613|Chromatiales E peptidase M24B, X-Pro dipeptidase aminopeptidase - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_1325170_2 1049564.TevJSym_ak00990 1.98e-16 78.6 COG3079@1|root,COG3079@2|Bacteria,1N7W0@1224|Proteobacteria,1SCPW@1236|Gammaproteobacteria,1J79S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0149 family ygfB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09895 - - - - ko00000 - - - UPF0149 k59_544570_1 349966.DJ58_3251 4.8e-14 77.8 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,41E55@629|Yersinia 1236|Gammaproteobacteria KL HELICc2 yoaA GO:0003674,GO:0003824,GO:0004386,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:1901360 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,ResIII k59_911279_1 1442599.JAAN01000035_gene680 2.2e-23 98.2 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1X33V@135614|Xanthomonadales 135614|Xanthomonadales H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_911279_2 710687.KI912270_gene4816 7.11e-57 189.0 COG2141@1|root,COG2141@2|Bacteria,2GMRE@201174|Actinobacteria,23EWI@1762|Mycobacteriaceae 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_497954_1 1232683.ADIMK_0681 1.28e-66 218.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,4641I@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - Glutaredoxin,PALP k59_753889_1 1123368.AUIS01000004_gene241 3.67e-217 621.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,2NCPF@225057|Acidithiobacillales 225057|Acidithiobacillales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_1283792_1 247490.KSU1_C1324 1.35e-101 338.0 COG1957@1|root,COG3055@1|root,COG3204@1|root,COG4932@1|root,COG1957@2|Bacteria,COG3055@2|Bacteria,COG3204@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - - ko:K02674,ko:K07004 - - - - ko00000,ko02035,ko02044 - - - DUF547,Laminin_G_3,Malectin k59_1068021_1 330214.NIDE4110 5.38e-103 313.0 COG0119@1|root,COG0119@2|Bacteria,3J0DC@40117|Nitrospirae 40117|Nitrospirae E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_129238_1 745411.B3C1_11429 9.66e-93 304.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1J56W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2902 NAD-specific glutamate dehydrogenase gdhB - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH,GDH_N k59_1491432_1 316067.Geob_1215 1.12e-130 391.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,42MKI@68525|delta/epsilon subdivisions,2WIQJ@28221|Deltaproteobacteria,43TCE@69541|Desulfuromonadales 28221|Deltaproteobacteria G Domain of unknown function (DUF3459) treZ - 3.2.1.141 ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3459 k59_813848_1 977880.RALTA_A2445 1.75e-21 94.4 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2VK1S@28216|Betaproteobacteria,1K1E7@119060|Burkholderiaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily btuC - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_813848_2 1323663.AROI01000006_gene2859 4.28e-62 197.0 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria 1236|Gammaproteobacteria E phosphoserine phosphatase - - - - - - - - - - - - HAD k59_497970_1 439235.Dalk_0513 1.3e-17 89.4 COG0664@1|root,COG1033@1|root,COG2199@1|root,COG0664@2|Bacteria,COG1033@2|Bacteria,COG2199@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MJQ7@213118|Desulfobacterales 28221|Deltaproteobacteria K MMPL family - - - ko:K07003 - - - - ko00000 - - - GGDEF,LolA_like,MMPL,cNMP_binding k59_82087_2 1229909.NSED_01245 1.2e-72 227.0 arCOG08783@1|root,arCOG08783@2157|Archaea,41SFX@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1283810_1 1144672.F966_00451 4.53e-187 531.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,3NKKZ@468|Moraxellaceae 1236|Gammaproteobacteria M Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_1168823_1 63737.Npun_R0578 1.25e-23 99.8 COG1028@1|root,COG1028@2|Bacteria,1G2ZD@1117|Cyanobacteria,1HMVA@1161|Nostocales 1117|Cyanobacteria IQ PFAM short chain dehydrogenase - - - - - - - - - - - - adh_short_C2 k59_442032_1 1299327.I546_3462 1.88e-47 166.0 COG1073@1|root,COG1073@2|Bacteria,2I8SP@201174|Actinobacteria,23AD2@1762|Mycobacteriaceae 201174|Actinobacteria S alpha beta - - - - - - - - - - - - - k59_1068045_1 1229780.BN381_150119 1.38e-44 166.0 COG0421@1|root,COG0421@2|Bacteria 2|Bacteria E spermidine synthase activity - - - - - - - - - - - - Spermine_synth k59_656834_1 1150599.MPHLEI_11709 0.000146 46.6 COG0451@1|root,COG0451@2|Bacteria,2GJ23@201174|Actinobacteria,23639@1762|Mycobacteriaceae 201174|Actinobacteria GM epimerase dehydratase - - - - - - - - - - - - Epimerase k59_813880_1 9733.XP_004278430.1 2.92e-18 89.0 COG0308@1|root,KOG1046@2759|Eukaryota,38CFG@33154|Opisthokonta,3BD0T@33208|Metazoa,3CUKR@33213|Bilateria,489DU@7711|Chordata,493AI@7742|Vertebrata,3J227@40674|Mammalia,4IW9N@91561|Cetartiodactyla 33208|Metazoa T aminopeptidase ANPEP GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003008,GO:0003013,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005793,GO:0005886,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0007154,GO:0007165,GO:0007267,GO:0008015,GO:0008150,GO:0008152,GO:0008217,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009897,GO:0009986,GO:0009987,GO:0012505,GO:0012506,GO:0016020,GO:0016192,GO:0016787,GO:0019538,GO:0023052,GO:0030141,GO:0030659,GO:0030667,GO:0031090,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032501,GO:0032879,GO:0032940,GO:0033218,GO:0034641,GO:0035813,GO:0035814,GO:0036230,GO:0038023,GO:0042119,GO:0042277,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043230,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0043603,GO:0044057,GO:0044062,GO:0044237,GO:0044238,GO:0044248,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0045055,GO:0045321,GO:0046872,GO:0046903,GO:0046914,GO:0048519,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051048,GO:0051049,GO:0051051,GO:0051179,GO:0051234,GO:0051239,GO:0051241,GO:0051716,GO:0060089,GO:0065007,GO:0065008,GO:0070006,GO:0070011,GO:0070062,GO:0071704,GO:0071944,GO:0097708,GO:0098552,GO:0098588,GO:0098801,GO:0098805,GO:0099503,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1903561 3.4.11.2 ko:K11140 ko00480,ko01100,ko04614,ko04640,map00480,map01100,map04614,map04640 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002,ko04090,ko04131,ko04147 - - - ERAP1_C,Peptidase_M1 k59_442044_1 502025.Hoch_1494 4.14e-56 196.0 2CC7E@1|root,2Z7WG@2|Bacteria,1R77M@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_656839_1 83406.HDN1F_04230 5.81e-20 89.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4G2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains cbrB - - - - - - - - - - - Response_reg,Sigma54_activat k59_656839_2 1042375.AFPL01000052_gene380 7.72e-36 135.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,4643M@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0591 Na proline symporter cbrA - - - - - - - - - - - HATPase_c,HisKA,PAS k59_336867_1 1279009.ADICEAN_01141 3.9e-06 47.4 COG1215@1|root,COG1215@2|Bacteria,4NF0S@976|Bacteroidetes,47KDC@768503|Cytophagia 976|Bacteroidetes M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_336867_2 314345.SPV1_07606 2.62e-132 382.0 COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria 1224|Proteobacteria GM Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides rmlB2 - 4.1.1.35,4.2.1.46 ko:K01710,ko:K08678 ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00793 R01384,R06513 RC00402,RC00508 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_497999_1 760117.JN27_02910 5.1e-27 116.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1Q33X@1224|Proteobacteria,2VKF9@28216|Betaproteobacteria 28216|Betaproteobacteria GT Pyruvate, water dikinase - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_442055_1 713587.THITH_01990 1.16e-78 249.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_1380562_2 324057.Pjdr2_4360 2.34e-19 90.1 COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,4H9SB@91061|Bacilli,26QIQ@186822|Paenibacillaceae 91061|Bacilli S Hemolysins and related proteins containing CBS domains corC3 - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1491487_1 388401.RB2150_04318 8.3e-28 119.0 COG5323@1|root,COG5323@2|Bacteria,1MW8S@1224|Proteobacteria,2TREI@28211|Alphaproteobacteria,3ZIC4@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria S Terminase-like family - - - - - - - - - - - - Terminase_6,Terminase_6C k59_1325226_1 402777.KB235904_gene3192 3.48e-74 251.0 COG0642@1|root,COG2199@1|root,COG3290@1|root,COG2205@2|Bacteria,COG3290@2|Bacteria,COG3706@2|Bacteria,1G13T@1117|Cyanobacteria,1H77Q@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_8,PAS_9,Response_reg k59_1168856_1 870187.Thini_1119 1.12e-21 94.0 COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,45ZTN@72273|Thiotrichales 72273|Thiotrichales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_1168856_2 228410.NE1417 1.17e-36 137.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2VIXM@28216|Betaproteobacteria,3725F@32003|Nitrosomonadales 28216|Betaproteobacteria M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_1015197_1 1229780.BN381_90015 1.23e-41 148.0 COG1804@1|root,COG1804@2|Bacteria,2I8ZJ@201174|Actinobacteria 201174|Actinobacteria C acyl-CoA transferases carnitine dehydratase - - - - - - - - - - - - CoA_transf_3 k59_656872_2 629773.AORY01000004_gene36 7.31e-22 94.4 COG0500@1|root,COG0500@2|Bacteria,1QUSR@1224|Proteobacteria,2U78U@28211|Alphaproteobacteria,2K1PP@204457|Sphingomonadales 204457|Sphingomonadales Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_23 k59_1015198_1 1111479.AXAR01000006_gene781 3.22e-123 371.0 COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,4HBVG@91061|Bacilli,277ZQ@186823|Alicyclobacillaceae 91061|Bacilli C SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556 - - - - - - - - - - - - FAD_binding_2,Succ_DH_flav_C k59_858938_1 1121396.KB893056_gene2640 4.47e-134 401.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WMD3@28221|Deltaproteobacteria,2MMTW@213118|Desulfobacterales 28221|Deltaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_9 k59_1168869_1 331869.BAL199_06664 1.52e-52 187.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria,4BR7H@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C 4Fe-4S dicluster domain MA20_43170 - - - - - - - - - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_911358_1 153948.NAL212_1477 2.23e-72 240.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,3724V@32003|Nitrosomonadales 28216|Betaproteobacteria I acyl-CoA dehydrogenase fadE - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_1228409_1 765910.MARPU_03685 3.64e-219 645.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1283898_1 1229909.NSED_09115 1.35e-23 99.4 COG1361@1|root,arCOG02080@2157|Archaea,41T6N@651137|Thaumarchaeota 651137|Thaumarchaeota M extracellular matrix structural constituent - - - - - - - - - - - - - k59_1283898_2 1229909.NSED_09120 2.13e-47 156.0 COG1136@1|root,arCOG00922@2157|Archaea,41T2R@651137|Thaumarchaeota 651137|Thaumarchaeota E ABC-type antimicrobial peptide transport system, ATPase component - - - ko:K02003,ko:K09810 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 - - ABC_tran k59_597459_1 399550.Smar_1366 5.6e-14 77.4 COG3379@1|root,arCOG01377@2157|Archaea,2XPVN@28889|Crenarchaeota 28889|Crenarchaeota S PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_498079_1 483219.LILAB_17770 1.28e-109 330.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ28@28221|Deltaproteobacteria,2YWA0@29|Myxococcales 28221|Deltaproteobacteria NU Type II/IV secretion system protein pilT-1 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1491546_1 436308.Nmar_0441 7.7e-90 268.0 COG2897@1|root,arCOG02019@2157|Archaea,41SZQ@651137|Thaumarchaeota 651137|Thaumarchaeota P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_1491546_2 436308.Nmar_0442 3.42e-38 129.0 arCOG08760@1|root,arCOG08760@2157|Archaea,41T7P@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1283925_1 1163617.SCD_n01470 8.85e-84 277.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria 28216|Betaproteobacteria F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_911393_1 330214.NIDE3976 1.29e-30 114.0 COG1651@1|root,COG1651@2|Bacteria 2|Bacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - - - - - - - - - - SurA_N_3,Thioredoxin_4 k59_911393_2 330214.NIDE3977 3.89e-89 271.0 COG1899@1|root,COG1899@2|Bacteria 2|Bacteria O peptidyl-lysine modification to peptidyl-hypusine - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS k59_1380603_1 123899.JPQP01000001_gene1647 9.16e-32 142.0 COG0243@1|root,COG1018@1|root,COG0243@2|Bacteria,COG1018@2|Bacteria,1NR6J@1224|Proteobacteria,2VJQ4@28216|Betaproteobacteria,3T7N2@506|Alcaligenaceae 28216|Betaproteobacteria C Molydopterin dinucleotide binding domain - - - - - - - - - - - - FAD_binding_6,Fer2,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NAD_binding_1 k59_442140_1 5111.M1VWX2 1.96e-05 51.2 KOG1681@1|root,KOG1681@2759|Eukaryota,38TRP@33154|Opisthokonta,3NU5A@4751|Fungi,3QKYA@4890|Ascomycota,2124G@147550|Sordariomycetes,3TE18@5125|Hypocreales,3G027@34397|Clavicipitaceae 4751|Fungi I enoyl-CoA hydratase isomerase family - - - ko:K12663 ko04146,map04146 - - - ko00000,ko00001,ko01000 - - - ECH_1 k59_390843_1 765911.Thivi_2465 6.49e-30 123.0 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria,1WWX3@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - 2.7.13.3 ko:K07673 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA_3 k59_284626_1 1380394.JADL01000003_gene4962 9.87e-42 158.0 COG1216@1|root,COG3934@1|root,COG1216@2|Bacteria,COG3934@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - - - - - - - - - - CBM_4_9,Cellulase,Glyco_hydro_2_C,Glycos_transf_2 k59_451387_1 1246459.KB898353_gene209 5.51e-35 129.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2TQSZ@28211|Alphaproteobacteria,4B7AY@82115|Rhizobiaceae 28211|Alphaproteobacteria E Belongs to the arginase family - - 3.5.3.11,3.5.3.17 ko:K01480,ko:K18459 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_1076861_1 1463825.JNXC01000018_gene6870 1.75e-08 61.6 COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4E0HP@85010|Pseudonocardiales 201174|Actinobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_1445782_1 626887.J057_04351 5.13e-70 236.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,46410@72275|Alteromonadaceae 1236|Gammaproteobacteria M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) mrcB - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_1237595_1 1439940.BAY1663_00273 7.01e-93 294.0 COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,1RMA1@1236|Gammaproteobacteria 1236|Gammaproteobacteria E ABC-type oligopeptide transport system, periplasmic component yejA GO:0005575,GO:0005623,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042493,GO:0042597,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K02035,ko:K13893 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 k59_866091_1 1454004.AW11_01971 2.39e-145 430.0 COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VIT2@28216|Betaproteobacteria,1KQE9@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria I Methylmalonyl-CoA mutase icmF - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase k59_138405_1 1047013.AQSP01000055_gene270 2.02e-59 199.0 COG0146@1|root,COG0146@2|Bacteria 2|Bacteria EQ ligase activity hyuB - 3.5.2.14,3.5.2.9 ko:K01469,ko:K01474 ko00330,ko00480,ko01100,map00330,map00480,map01100 - R00251,R03187 RC00553,RC00632 ko00000,ko00001,ko01000 - - iNJ661.Rv0266c Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_711103_1 1283284.AZUK01000001_gene2534 2.82e-69 235.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1Y3TQ@135624|Aeromonadales 135624|Aeromonadales F Carbamoyl-phosphate synthetase ammonia chain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_1654825_1 330214.NIDE4134 1.72e-57 189.0 COG0195@1|root,COG0195@2|Bacteria,3J0DF@40117|Nitrospirae 40117|Nitrospirae K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_5,NusA_N,S1 k59_1654825_2 349161.Dred_1957 7.8e-06 53.9 COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,260ER@186807|Peptococcaceae 186801|Clostridia J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_239085_1 1121875.KB907553_gene20 1.25e-29 117.0 COG5361@1|root,COG5361@2|Bacteria,4NKSK@976|Bacteroidetes,1IARY@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_1596739_1 1255043.TVNIR_1094 8.02e-86 287.0 COG0637@1|root,COG1554@1|root,COG1877@1|root,COG0637@2|Bacteria,COG1554@2|Bacteria,COG1877@2|Bacteria,1RCD8@1224|Proteobacteria,1SDYG@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Haloacid dehalogenase-like hydrolase - - 3.2.1.28 ko:K01194 ko00500,ko01100,map00500,map01100 - R00010 RC00049 ko00000,ko00001,ko00537,ko01000 - GH37 - HAD_2 k59_1128998_1 1198232.CYCME_2488 5.54e-47 169.0 COG1333@1|root,COG1333@2|Bacteria,1N6XE@1224|Proteobacteria,1RXXZ@1236|Gammaproteobacteria,46045@72273|Thiotrichales 72273|Thiotrichales O Cytochrome c-type biogenesis protein Ccs1 ResB - - - ko:K07399 - - - - ko00000 - - - ResB k59_711109_1 314285.KT71_00580 1.2e-08 58.2 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,1RMZ2@1236|Gammaproteobacteria,1J5N6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Anion-transporting ATPase fleN - - ko:K04562 - - - - ko00000,ko02035 - - - CbiA,ParA k59_711109_2 1195246.AGRI_00475 9.97e-24 96.7 COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,1RMKJ@1236|Gammaproteobacteria,465DJ@72275|Alteromonadaceae 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_604363_2 195250.CM001776_gene1054 4.06e-46 167.0 COG3264@1|root,COG3264@2|Bacteria,1G2UD@1117|Cyanobacteria,1GZWW@1129|Synechococcus 1117|Cyanobacteria M Small-conductance mechanosensitive channel - - - - - - - - - - - - MS_channel k59_1596745_1 1129794.C427_2890 3.05e-26 110.0 COG2203@1|root,COG2203@2|Bacteria 2|Bacteria T Gaf domain - - - - - - - - - - - - EAL,GAF,GAF_2,GGDEF,Guanylate_cyc,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1501531_1 935567.JAES01000015_gene2789 2.15e-20 90.5 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,1X4P4@135614|Xanthomonadales 135614|Xanthomonadales D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_451425_1 1379698.RBG1_1C00001G1718 4.26e-08 63.2 COG0438@1|root,COG0438@2|Bacteria,2NNZH@2323|unclassified Bacteria 2|Bacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_1501535_1 1131266.ARWQ01000005_gene812 1.83e-33 120.0 COG0822@1|root,arCOG02077@2157|Archaea,41SPT@651137|Thaumarchaeota 651137|Thaumarchaeota C SUF system FeS assembly protein - - - ko:K04488 - - - - ko00000 - - - NifU_N k59_1501535_2 436308.Nmar_0499 1.25e-60 188.0 arCOG08758@1|root,arCOG08758@2157|Archaea,41SVS@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1076901_1 1175306.GWL_21610 2.21e-40 152.0 COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VHPI@28216|Betaproteobacteria,475S0@75682|Oxalobacteraceae 28216|Betaproteobacteria T Double sensory domain of two-component sensor kinase - - - - - - - - - - - - EAL,GGDEF,HAMP,dCache_3 k59_451438_1 1121374.KB891586_gene2791 1.38e-29 118.0 COG3182@1|root,COG3182@2|Bacteria,1QVX4@1224|Proteobacteria,1T2MJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PepSY-associated TM region - - - - - - - - - - - - PepSY_TM k59_1501550_1 436308.Nmar_0748 3e-123 372.0 COG0480@1|root,arCOG01559@2157|Archaea,41S9B@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K03234 ko04152,ko04921,map04152,map04921 - - - ko00000,ko00001,ko03012,ko04147 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1022288_1 1123392.AQWL01000003_gene322 4.74e-64 214.0 COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,1KRDI@119069|Hydrogenophilales 119069|Hydrogenophilales M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_138456_1 283942.IL2457 1.28e-85 266.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,2QF9V@267893|Idiomarinaceae 1236|Gammaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_1175552_1 1229909.NSED_06385 2.13e-103 309.0 COG0372@1|root,arCOG04237@2157|Archaea,41SAN@651137|Thaumarchaeota 651137|Thaumarchaeota C TIGRFAM 2-methylcitrate synthase citrate synthase II - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_293368_1 246197.MXAN_1284 4.18e-40 146.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2YTZB@29|Myxococcales 28221|Deltaproteobacteria E synthase homocitrate synthase family - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_1445831_1 1175306.GWL_44920 9.6e-12 64.7 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,472M3@75682|Oxalobacteraceae 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_824204_1 379066.GAU_3734 1.78e-34 134.0 COG1807@1|root,COG1807@2|Bacteria,1ZUFB@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_1501570_1 1173022.Cri9333_4570 6.98e-07 52.0 COG1813@1|root,COG1813@2|Bacteria 2|Bacteria K peptidyl-tyrosine sulfation ydcN - - - - - - - - - - - Cupin_2,HTH_3,HTH_31 k59_1501570_2 1078020.KEK_10733 8.43e-12 72.0 COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria,234XF@1762|Mycobacteriaceae 201174|Actinobacteria K Belongs to the ParB family parB GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944 - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_969785_1 1187851.A33M_2180 1.04e-13 73.6 COG2141@1|root,COG2141@2|Bacteria,1MWDV@1224|Proteobacteria,2TV51@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_761047_1 1458427.BAWN01000015_gene985 0.000788 45.4 COG0845@1|root,COG0845@2|Bacteria,1PJHF@1224|Proteobacteria,2VIRN@28216|Betaproteobacteria,4ADVF@80864|Comamonadaceae 28216|Betaproteobacteria M HlyD family secretion protein - - - ko:K02005 - - - - ko00000 - - - HlyD_3 k59_761047_2 1123368.AUIS01000013_gene846 2.84e-33 126.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,2NCEA@225057|Acidithiobacillales 1236|Gammaproteobacteria M Lipoprotein releasing system transmembrane protein LolC lolE GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0098796,GO:0098797 - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_293379_1 331869.BAL199_18541 6.33e-96 289.0 COG1834@1|root,COG1834@2|Bacteria,1R7NG@1224|Proteobacteria,2U4ZK@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Amidinotransferase - - - - - - - - - - - - Amidinotransf k59_711172_2 366394.Smed_3034 1.2e-11 63.9 COG1028@1|root,COG1028@2|Bacteria,1PGYI@1224|Proteobacteria,2U4D8@28211|Alphaproteobacteria,4BM4U@82115|Rhizobiaceae 28211|Alphaproteobacteria IQ KR domain - - 1.1.1.406 ko:K21702 - - - - ko00000,ko01000 - - - adh_short_C2 k59_508278_1 269797.Mbar_A1114 2.07e-20 94.4 COG0438@1|root,arCOG01410@2157|Archaea,2XV5R@28890|Euryarchaeota 28890|Euryarchaeota M COG0438 Glycosyltransferase - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_1076952_1 396588.Tgr7_2086 9.85e-20 86.3 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,1RPJH@1236|Gammaproteobacteria,1WWU7@135613|Chromatiales 135613|Chromatiales L PFAM Transposase IS200 like - - - - - - - - - - - - Bac_DnaA_C,Y1_Tnp k59_1654929_1 330214.NIDE1189 2.98e-65 204.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_451505_1 1120950.KB892745_gene2935 1.07e-12 73.9 COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,4DNPC@85009|Propionibacteriales 201174|Actinobacteria C FAD dependent oxidoreductase - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_1654933_1 1109445.AGSX01000148_gene615 9.63e-80 253.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1Z0V0@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_1237702_1 330214.NIDE2536 2.34e-92 289.0 COG0021@1|root,COG0021@2|Bacteria,3J0MM@40117|Nitrospirae 40117|Nitrospirae G Transketolase, pyrimidine binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_1445859_1 935567.JAES01000052_gene2551 5e-70 222.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1X3ZA@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_451513_1 1207063.P24_04644 8.13e-94 283.0 COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TSRF@28211|Alphaproteobacteria,2JQ3B@204441|Rhodospirillales 204441|Rhodospirillales ET general L-amino acid-binding periplasmic protein AapJ - - - ko:K09969 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - SBP_bac_3 k59_1129086_1 62928.azo3813 1.63e-33 122.0 COG2802@1|root,COG2802@2|Bacteria,1RFYH@1224|Proteobacteria,2VSA4@28216|Betaproteobacteria,2KWC8@206389|Rhodocyclales 206389|Rhodocyclales S peptidase S16 - - - ko:K07157 - - - - ko00000 - - - LON_substr_bdg k59_1129086_2 1051646.VITU9109_08046 6.65e-14 72.8 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria,1XTVH@135623|Vibrionales 135623|Vibrionales M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_711190_1 1121921.KB898708_gene1513 9.96e-24 104.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,2PNA6@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L ABC transporter - - - - - - - - - - - - ABC_tran k59_824247_1 330214.NIDE4279 3.83e-48 164.0 COG1994@1|root,COG1994@2|Bacteria,3J0KK@40117|Nitrospirae 40117|Nitrospirae S Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 k59_1294128_2 460265.Mnod_4364 6.18e-13 71.2 COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,2U3N3@28211|Alphaproteobacteria,1JTVF@119045|Methylobacteriaceae 28211|Alphaproteobacteria M PFAM glycosyl transferase group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_1387287_1 388413.ALPR1_02700 2.64e-39 149.0 COG4888@1|root,COG4888@2|Bacteria,4NEE8@976|Bacteroidetes,47MQH@768503|Cytophagia 976|Bacteroidetes S ASPIC UnbV domain protein - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_1175602_1 1541065.JRFE01000024_gene1084 1.78e-34 127.0 COG0714@1|root,COG0714@2|Bacteria,1G0WS@1117|Cyanobacteria,3VNGC@52604|Pleurocapsales 1117|Cyanobacteria S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1175602_2 543913.D521_1454 1.02e-15 76.6 COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2VREV@28216|Betaproteobacteria,1KQQ5@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria L NUDIX domain - - - - - - - - - - - - NUDIX k59_397347_1 1149133.ppKF707_1109 5.19e-19 89.0 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1TBT1@1236|Gammaproteobacteria,1YIX9@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_1239117_1 1162668.LFE_1484 1.7e-14 79.3 COG2203@1|root,COG3605@1|root,COG2203@2|Bacteria,COG3605@2|Bacteria,3J0XQ@40117|Nitrospirae 40117|Nitrospirae T ANTAR - - - - - - - - - - - - ANTAR,GAF_2 k59_1656457_1 290397.Adeh_4252 1.18e-108 325.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2YUPP@29|Myxococcales 28221|Deltaproteobacteria H glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_15017_1 237368.SCABRO_00961 1.53e-07 58.9 COG1538@1|root,COG1538@2|Bacteria,2IZ8Q@203682|Planctomycetes 203682|Planctomycetes MU PFAM Outer membrane efflux protein - - - - - - - - - - - - OEP k59_346731_1 1380355.JNIJ01000050_gene131 2.73e-85 261.0 COG4177@1|root,COG4177@2|Bacteria,1N5I8@1224|Proteobacteria,2U0PT@28211|Alphaproteobacteria,3JSC7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_139887_1 1232410.KI421415_gene3039 2.62e-40 147.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2WIXA@28221|Deltaproteobacteria,43T3H@69541|Desulfuromonadales 28221|Deltaproteobacteria H Pterin binding enzyme folP - 2.5.1.15,2.7.6.3 ko:K00796,ko:K13941 ko00790,ko01100,map00790,map01100 M00126,M00840,M00841 R03066,R03067,R03503 RC00002,RC00017,RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_867140_1 686340.Metal_1949 8.73e-42 156.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,1XEIK@135618|Methylococcales 135618|Methylococcales KT PFAM RNA polymerase sigma factor 54, interaction - - - - - - - - - - - - HTH_8,PAS_4,Sigma54_activat k59_1656468_2 1121013.P873_04035 3.19e-39 140.0 COG0258@1|root,COG0258@2|Bacteria,1RAAR@1224|Proteobacteria,1RN1S@1236|Gammaproteobacteria,1X448@135614|Xanthomonadales 135614|Xanthomonadales L Exodeoxyribonuclease IX exo - - - - - - - - - - - 5_3_exonuc,5_3_exonuc_N k59_921802_1 685035.ADAE01000018_gene859 5.94e-16 75.9 COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2U77S@28211|Alphaproteobacteria,2K4ID@204457|Sphingomonadales 204457|Sphingomonadales I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_921802_2 313606.M23134_00376 7.28e-40 142.0 COG0057@1|root,COG0057@2|Bacteria,4NEMF@976|Bacteroidetes,47KPU@768503|Cytophagia 976|Bacteroidetes G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_1597732_1 518766.Rmar_1488 5.04e-55 181.0 COG1313@1|root,COG1313@2|Bacteria 2|Bacteria C radical SAM domain protein PflX - 1.97.1.4 ko:K04070 - - - - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_1130412_1 436308.Nmar_1245 1.76e-52 185.0 COG0419@1|root,COG1122@1|root,arCOG00202@2157|Archaea,arCOG00368@2157|Archaea,41S9P@651137|Thaumarchaeota 651137|Thaumarchaeota LP AAA domain - - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_15 k59_1503149_1 401526.TcarDRAFT_2677 1.69e-66 226.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,4H28C@909932|Negativicutes 909932|Negativicutes L ATP-dependent DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_294725_1 765912.Thimo_3702 0.000419 50.1 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1WWKE@135613|Chromatiales 135613|Chromatiales U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_553222_2 1120953.AUBH01000016_gene2872 2.12e-15 77.4 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,465BT@72275|Alteromonadaceae 1236|Gammaproteobacteria S exporters of the RND superfamily VP1286 - - ko:K07003 - - - - ko00000 - - - MMPL k59_1087458_1 1079460.ATTQ01000001_gene5834 1.25e-42 164.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,4B81Q@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_875480_1 264203.ZMO0543 4.25e-18 84.3 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,2K0CP@204457|Sphingomonadales 204457|Sphingomonadales C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_875480_2 330214.NIDE0837 1.5e-77 251.0 COG2838@1|root,COG2838@2|Bacteria 2|Bacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_1668643_1 96561.Dole_0673 4.27e-65 221.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MIKT@213118|Desulfobacterales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_521778_2 1449347.JQLN01000006_gene2494 8.38e-06 50.1 COG0438@1|root,COG0438@2|Bacteria,2GM53@201174|Actinobacteria 201174|Actinobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_1454271_1 646529.Desaci_1858 5.41e-62 211.0 COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24DPN@186801|Clostridia,260G2@186807|Peptococcaceae 186801|Clostridia I TIGRFAM Acetoacetyl-CoA synthase - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1604407_1 497964.CfE428DRAFT_3367 4.05e-33 126.0 COG3344@1|root,COG3344@2|Bacteria,46UR2@74201|Verrucomicrobia 74201|Verrucomicrobia L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_1546397_1 1232410.KI421415_gene2961 2.67e-41 155.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2WJ76@28221|Deltaproteobacteria,43S4V@69541|Desulfuromonadales 28221|Deltaproteobacteria L GIY-YIG type nucleases (URI domain) uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_521803_2 1307759.JOMJ01000003_gene1049 3.15e-09 59.7 COG1381@1|root,COG1381@2|Bacteria,1RIBW@1224|Proteobacteria,42PUE@68525|delta/epsilon subdivisions,2WK4W@28221|Deltaproteobacteria,2M7SE@213115|Desulfovibrionales 28221|Deltaproteobacteria L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_720966_1 2340.JV46_04000 1.03e-72 228.0 COG1073@1|root,COG1073@2|Bacteria,1N595@1224|Proteobacteria,1SAUZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Serine aminopeptidase, S33 - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 k59_1184054_2 29495.EA26_03245 3.09e-51 172.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1XV0G@135623|Vibrionales 135623|Vibrionales F carbamoyl-phosphate synthetase glutamine chain carA GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006139,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_613589_1 1408452.JAGZ01000006_gene778 1.88e-06 47.4 COG1024@1|root,COG1024@2|Bacteria,2IBN1@201174|Actinobacteria,237N9@1762|Mycobacteriaceae 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_613589_2 1068978.AMETH_3225 5.59e-32 130.0 COG0183@1|root,COG0183@2|Bacteria,2I3PP@201174|Actinobacteria 201174|Actinobacteria I Acetyl-CoA acetyltransferase - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - - k59_304059_1 357808.RoseRS_2714 5.27e-71 246.0 COG3250@1|root,COG3250@2|Bacteria,2G61D@200795|Chloroflexi,377DI@32061|Chloroflexia 32061|Chloroflexia G glycoside hydrolase family 2, immunoglobulin domain protein beta-sandwich - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_356071_1 869724.H6BI46_9CAUD 4.71e-32 131.0 4QEE7@10239|Viruses,4QV59@35237|dsDNA viruses no RNA stage,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae 10662|Myoviridae S Pfam:DUF4815 - - - - - - - - - - - - - k59_1247215_1 391615.ABSJ01000042_gene2245 1.7e-21 87.4 COG3785@1|root,COG3785@2|Bacteria,1RHM7@1224|Proteobacteria,1SXW8@1236|Gammaproteobacteria,1JBNJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Hemimethylated DNA-binding protein YccV like - - - - - - - - - - - - YccV-like k59_1247215_2 1123368.AUIS01000001_gene1892 5.61e-22 93.2 COG3160@1|root,COG3160@2|Bacteria,1RHBB@1224|Proteobacteria,1S420@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase rsd GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - ko:K07740 - - - - ko00000 - - - Rsd_AlgQ k59_1668696_1 314231.FP2506_13944 3.9e-98 295.0 COG3555@1|root,COG3555@2|Bacteria,1MW3M@1224|Proteobacteria,2TRVQ@28211|Alphaproteobacteria,2PJAC@255475|Aurantimonadaceae 28211|Alphaproteobacteria O Aspartyl/Asparaginyl beta-hydroxylase MA20_07860 - 1.14.11.16 ko:K00476,ko:K12979 - - - - ko00000,ko01000,ko01005 - - - Asp_Arg_Hydrox k59_613598_1 460265.Mnod_2965 9.62e-21 90.5 COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2TUT7@28211|Alphaproteobacteria,1JSXA@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM 2-nitropropane dioxygenase NPD - - 1.13.12.16,1.3.1.9 ko:K00459,ko:K02371 ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212 M00083 R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076,RC02541,RC02759 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO k59_613598_2 101510.RHA1_ro11181 2.59e-56 186.0 COG0447@1|root,COG0447@2|Bacteria,2HGHM@201174|Actinobacteria,4FZY1@85025|Nocardiaceae 201174|Actinobacteria H Enoyl-CoA hydratase/isomerase - - 4.1.3.36 ko:K01661,ko:K07536 ko00130,ko00362,ko01100,ko01110,ko01120,ko01220,map00130,map00362,map01100,map01110,map01120,map01220 M00116,M00540 R05592,R07263 RC01429,RC01923 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1031993_1 1458357.BG58_09765 2.98e-27 112.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2VH0T@28216|Betaproteobacteria,1K39X@119060|Burkholderiaceae 28216|Betaproteobacteria Q carboxymethylenebutenolidase clcD - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_1139490_1 589865.DaAHT2_2305 1.67e-57 200.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,2MI09@213118|Desulfobacterales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1247228_2 1172180.KB911792_gene3842 2.69e-10 61.6 COG3409@1|root,COG3409@2|Bacteria,2GSPU@201174|Actinobacteria 201174|Actinobacteria M Putative peptidoglycan binding domain - - - - - - - - - - - - PG_binding_1 k59_406662_1 1260251.SPISAL_00760 1.37e-28 113.0 COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,1S8HZ@1236|Gammaproteobacteria,1X2EY@135613|Chromatiales 135613|Chromatiales K helix_turn_helix, cAMP Regulatory protein - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_613612_1 316274.Haur_2403 2.45e-42 157.0 COG2304@1|root,COG2304@2|Bacteria,2GA79@200795|Chloroflexi,375RC@32061|Chloroflexia 2|Bacteria Q SMART Integrin alpha beta-propellor repeat protein - - - - - - - - - - - - DUF11,FG-GAP_2,FctA,VWA,VWA_2 k59_1139501_2 997346.HMPREF9374_1578 3.75e-61 200.0 COG0160@1|root,COG0160@2|Bacteria,1TRUG@1239|Firmicutes,4HBUU@91061|Bacilli,27BQ0@186824|Thermoactinomycetaceae 91061|Bacilli E Aminotransferase class-III ectB - 2.6.1.76 ko:K00836 ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230 M00033 R06977 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1668722_1 404589.Anae109_2968 2.64e-106 323.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,42P6Z@68525|delta/epsilon subdivisions,2WK5W@28221|Deltaproteobacteria,2YUMK@29|Myxococcales 28221|Deltaproteobacteria G Maltogenic Amylase, C-terminal domain treS - 2.4.1.4,3.2.1.1,5.4.99.16 ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_1396570_1 358681.BBR47_30890 1.71e-13 73.2 COG2055@1|root,COG2055@2|Bacteria,1TR0Z@1239|Firmicutes,4HB6X@91061|Bacilli,26WJP@186822|Paenibacillaceae 91061|Bacilli C Malate/L-lactate dehydrogenase - - 1.1.1.350 ko:K00073 ko00230,ko01120,map00230,map01120 - R02935,R02936 RC00169 ko00000,ko00001,ko01000 - - - Ldh_2 k59_1140789_1 1192034.CAP_2432 5.44e-63 207.0 COG0303@1|root,COG0303@2|Bacteria 2|Bacteria H 'Molybdopterin - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1184909_1 568768.CM001975_gene1127 6.66e-21 89.4 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,2JBNN@204037|Dickeya 1236|Gammaproteobacteria H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.5.4.4 ko:K00969,ko:K01488 ko00230,ko00760,ko01100,ko05340,map00230,map00760,map01100,map05340 M00115 R00137,R01560,R02556,R03005 RC00002,RC00477 ko00000,ko00001,ko00002,ko01000 - - iECUMN_1333.ECUMN_0733,iJN746.PP_4810,iPC815.YPO2607,iSbBS512_1146.SbBS512_E0612 CTP_transf_like k59_305100_1 195250.CM001776_gene2548 1.41e-08 58.5 COG4584@1|root,COG4584@2|Bacteria,1GBWH@1117|Cyanobacteria 1117|Cyanobacteria L PFAM Integrase core domain - - - - - - - - - - - - rve k59_305100_2 322710.Avin_49640 7.12e-19 87.4 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,1RPJM@1236|Gammaproteobacteria 1236|Gammaproteobacteria L ATP-binding protein, IstB SW ISTB_ECOLI (P15026) (265 aa) fasta scores E() 0, 47.4 id in 249 aa. Also almost identical to Yersinia pestis and Escherichia coli - - - - - - - - - - - - IstB_IS21 k59_103692_1 1266914.ATUK01000011_gene2575 1.86e-06 51.2 2C7AT@1|root,338A4@2|Bacteria,1NF74@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_103692_2 511062.GU3_14130 9.95e-94 284.0 COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,1RNTW@1236|Gammaproteobacteria,1Y41H@135624|Aeromonadales 135624|Aeromonadales F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate purT - 2.1.2.2 ko:K08289 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp,Epimerase k59_1341188_1 2340.JV46_11760 2.52e-99 296.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1J4K1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the peptidase M48B family htpX GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044425,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_876501_1 96561.Dole_0673 1.59e-72 241.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MIKT@213118|Desulfobacterales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_407774_2 983545.Glaag_3362 1.2e-30 118.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,465TH@72275|Alteromonadaceae 1236|Gammaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_1032986_1 1121918.ARWE01000001_gene754 9.63e-22 91.7 COG2716@1|root,COG2716@2|Bacteria,1Q2TM@1224|Proteobacteria,42W89@68525|delta/epsilon subdivisions,2WSEF@28221|Deltaproteobacteria,43V1Y@69541|Desulfuromonadales 28221|Deltaproteobacteria E ACT domain - - - - - - - - - - - - ACT_6 k59_1670144_1 553385.JEMF01000004_gene3435 1.06e-27 115.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - DUF4347,HCBP_related,Hint_2,Laminin_G_3,Reprolysin_4 k59_1341197_1 553973.CLOHYLEM_03950 7.63e-29 120.0 COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,24ASN@186801|Clostridia,21XF0@1506553|Lachnoclostridium 186801|Clostridia L DNA polymerase III, delta subunit holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta k59_357119_1 1121927.GOHSU_02_00550 5.4e-16 81.3 COG2267@1|root,COG2267@2|Bacteria,2GMY4@201174|Actinobacteria,4GFAV@85026|Gordoniaceae 201174|Actinobacteria I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_1670161_1 525897.Dbac_0008 1.15e-21 99.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - HemolysinCabind k59_1455255_1 136273.GY22_07080 2.98e-20 88.6 COG0214@1|root,COG0214@2|Bacteria,2GK1T@201174|Actinobacteria,1W7GP@1268|Micrococcaceae 201174|Actinobacteria H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively pdxS GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 ko:K06215 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SOR_SNZ k59_1455255_2 1267533.KB906738_gene2147 3.98e-54 179.0 COG0311@1|root,COG0311@2|Bacteria,3Y4GN@57723|Acidobacteria,2JJ3V@204432|Acidobacteriia 204432|Acidobacteriia H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS pdxT - 4.3.3.6 ko:K08681 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SNO k59_192640_1 1437824.BN940_10281 3.9e-29 114.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2VH6N@28216|Betaproteobacteria,3T1EB@506|Alcaligenaceae 28216|Betaproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_192640_2 349106.PsycPRwf_1726 1.16e-09 61.2 COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,1SAMR@1236|Gammaproteobacteria,3NQ9X@468|Moraxellaceae 1236|Gammaproteobacteria S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - Abhydrolase_6,PGAP1 k59_771334_1 1049564.TevJSym_av00320 2.2e-11 68.6 COG3156@1|root,COG3156@2|Bacteria,1RAQM@1224|Proteobacteria,1S2N8@1236|Gammaproteobacteria,1J6J6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U COG3156 Type II secretory pathway, component PulK gspK GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_407812_1 1454004.AW11_01669 2.05e-63 207.0 COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2VIRF@28216|Betaproteobacteria 28216|Betaproteobacteria E TIGRFAM LAO AO transport system ATPase - - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k59_407812_2 1415756.JQMY01000001_gene3561 6.17e-23 98.2 COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,2PCRH@252301|Oceanicola 28211|Alphaproteobacteria I Methylmalonyl-CoA mutase mutB - 5.4.99.63 ko:K14447 ko00630,ko01120,ko01200,map00630,map01120,map01200 M00373 R09292 RC02835 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase k59_614755_2 457570.Nther_0735 2.74e-39 137.0 COG0225@1|root,COG0225@2|Bacteria,1TQ3E@1239|Firmicutes,247UT@186801|Clostridia 186801|Clostridia O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K07304,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_1396632_1 159749.E7BWN5 2.3e-73 231.0 COG0201@1|root,2QSNV@2759|Eukaryota 2759|Eukaryota U protein transport secY GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006996,GO:0008150,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0009657,GO:0009668,GO:0009987,GO:0010027,GO:0016020,GO:0016043,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035,GO:0061024,GO:0071840 - ko:K10956 ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110 M00401 - - ko00000,ko00001,ko00002,ko02044 3.A.5.4,3.A.5.8,3.A.5.9 - - SecY k59_192669_1 268746.Q58MP8_BPPRM 2.41e-132 379.0 4QEZK@10239|Viruses,4QUSD@35237|dsDNA viruses no RNA stage,4QTHB@28883|Caudovirales,4QJXB@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1341241_1 314230.DSM3645_14770 3.07e-102 311.0 COG3119@1|root,COG3119@2|Bacteria,2IWVY@203682|Planctomycetes 203682|Planctomycetes P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_407834_1 436308.Nmar_0214 3.26e-49 169.0 COG0044@1|root,arCOG00689@2157|Archaea,41S8A@651137|Thaumarchaeota 651137|Thaumarchaeota F Amidohydrolase family - - 3.5.2.2 ko:K01464 ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100 M00046 R02269,R03055,R08227 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Amidohydro_1 k59_1341245_1 159087.Daro_3074 1.57e-56 179.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2VH1H@28216|Betaproteobacteria,2KV5Y@206389|Rhodocyclales 206389|Rhodocyclales E Acetolactate synthase small ilvH - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT_5,ALS_ss_C k59_1341245_2 1165096.ARWF01000001_gene2219 3.74e-11 63.9 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,2KM1K@206350|Nitrosomonadales 206350|Nitrosomonadales E TIGRFAM acetolactate synthase, large subunit, biosynthetic type - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1140894_1 382464.ABSI01000012_gene2213 1.08e-77 259.0 COG3696@1|root,COG3696@2|Bacteria,46USJ@74201|Verrucomicrobia,2ITM5@203494|Verrucomicrobiae 203494|Verrucomicrobiae P AcrB/AcrD/AcrF family - - - ko:K07239 - - - - ko00000 2.A.6.1 - - ACR_tran k59_1033049_1 247634.GPB2148_758 3.09e-56 189.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1J4UX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG1131 ABC-type multidrug transport system, ATPase component ybhF - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1033051_2 290397.Adeh_0047 1.66e-13 70.9 2DMP9@1|root,32SV1@2|Bacteria,1N17Y@1224|Proteobacteria,42TQF@68525|delta/epsilon subdivisions,2WQHJ@28221|Deltaproteobacteria,2Z109@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF3015) - - - - - - - - - - - - DUF3015 k59_1248159_1 207559.Dde_3621 9.05e-22 98.2 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria,2M80Z@213115|Desulfovibrionales 28221|Deltaproteobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_1670234_1 384676.PSEEN0746 6.3e-29 120.0 COG2931@1|root,COG3210@1|root,COG4733@1|root,COG4932@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4733@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - DUF4214,DUF4347,FecR,He_PIG,PATR k59_1088639_1 1125779.HMPREF1219_00527 3.61e-08 57.0 COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,22KB5@1653|Corynebacteriaceae 201174|Actinobacteria K transcriptional merR2 - - - - - - - - - - - MerR_1 k59_932289_1 382464.ABSI01000014_gene1485 1.21e-90 294.0 COG0841@1|root,COG0841@2|Bacteria,46Z6Y@74201|Verrucomicrobia,2ITZB@203494|Verrucomicrobiae 203494|Verrucomicrobiae V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_192698_1 395493.BegalDRAFT_0391 3.37e-78 250.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,46011@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_932292_1 330214.NIDE1410 1.11e-55 184.0 COG0248@1|root,COG0248@2|Bacteria,3J0K5@40117|Nitrospirae 40117|Nitrospirae FP Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_562896_1 436308.Nmar_0832 1.25e-62 203.0 COG1253@1|root,arCOG00626@2157|Archaea,41T1G@651137|Thaumarchaeota 651137|Thaumarchaeota S Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1547637_1 96561.Dole_0341 1.04e-90 282.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2MHTP@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1276 CTP_synth_N,GATase k59_1140922_1 330214.NIDE3757 2.79e-54 180.0 COG0589@1|root,COG0589@2|Bacteria 2|Bacteria T AMP binding - - - - - - - - - - - - Usp k59_207423_2 396588.Tgr7_2334 7.05e-29 109.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1WW17@135613|Chromatiales 135613|Chromatiales J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_781280_1 1229909.NSED_09935 2.73e-07 53.1 COG5491@1|root,arCOG00452@2157|Archaea,41SJ3@651137|Thaumarchaeota 651137|Thaumarchaeota D conserved protein implicated in secretion - - - - - - - - - - - - - k59_1561954_1 224324.aq_2077 1.89e-122 366.0 COG0733@1|root,COG0733@2|Bacteria,2G3UH@200783|Aquificae 200783|Aquificae S Sodium:neurotransmitter symporter family - - - - - - - - - - - - SNF k59_781289_1 225937.HP15_2665 4.02e-13 70.9 COG5488@1|root,COG5488@2|Bacteria,1N9B7@1224|Proteobacteria,1SF1J@1236|Gammaproteobacteria,46CDG@72275|Alteromonadaceae 1236|Gammaproteobacteria S Integral membrane protein (DUF2244) - - - - - - - - - - - - DUF2244 k59_781289_2 298386.PBPRA0167 9.1e-26 105.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1XSF8@135623|Vibrionales 135623|Vibrionales C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_260407_1 1499967.BAYZ01000095_gene4114 7.65e-50 191.0 COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria 2|Bacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_781301_1 13035.Dacsa_1991 4.24e-62 201.0 COG0294@1|root,COG0294@2|Bacteria,1G050@1117|Cyanobacteria 1117|Cyanobacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 ko:K00796,ko:K18824 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000,ko01504 - - - Pterin_bind k59_1562005_1 1160137.KB907307_gene1118 1.09e-28 117.0 COG5285@1|root,COG5285@2|Bacteria,2IC8K@201174|Actinobacteria 201174|Actinobacteria Q Phytanoyl-CoA dioxygenase (PhyH) - - - - - - - - - - - - PhyH k59_24457_1 1123368.AUIS01000037_gene28 5.97e-66 209.0 COG0637@1|root,COG0637@2|Bacteria 2|Bacteria S phosphonoacetaldehyde hydrolase activity pgmB GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008801,GO:0009058,GO:0009292,GO:0009294,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0019203,GO:0030312,GO:0033554,GO:0034637,GO:0040007,GO:0042221,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046351,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0071704,GO:0071944,GO:1901576 2.4.1.64,3.1.3.12,3.2.1.28,5.4.2.6 ko:K01087,ko:K01194,ko:K01838,ko:K05342 ko00500,ko01100,map00500,map01100 - R00010,R02727,R02728,R02778,R11310 RC00017,RC00049,RC00408 ko00000,ko00001,ko00537,ko01000 - GH37,GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Hydrolase,Trehalose_PPase k59_24457_2 1307759.JOMJ01000003_gene894 3.54e-87 273.0 COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria,2MA96@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM Glycosyl transferase, family 20 otsAB - 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,S6PP,Trehalose_PPase k59_1562029_1 1121456.ATVA01000012_gene2940 6.97e-06 54.3 COG3307@1|root,COG3307@2|Bacteria,1N225@1224|Proteobacteria,42QDQ@68525|delta/epsilon subdivisions,2WM6B@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM O-Antigen - - - ko:K18814 - - - - ko00000,ko02000 9.B.67.1 - - TPR_14,TPR_16,TPR_8,Wzy_C k59_1042980_1 240292.Ava_4009 9.79e-149 440.0 COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,1G04W@1117|Cyanobacteria,1HQD4@1161|Nostocales 1117|Cyanobacteria J Degrades phycobiliproteins in vitro. Has a substrate specificity prcA - - - - - - - - - - - P_proprotein,Peptidase_S8 k59_1562069_1 1217715.F994_00299 9.13e-23 93.2 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S9GR@1236|Gammaproteobacteria,3NP5A@468|Moraxellaceae 1236|Gammaproteobacteria D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB k59_886593_2 686578.AFFX01000010_gene2333 7.76e-48 159.0 COG2050@1|root,COG2050@2|Bacteria,1N5HF@1224|Proteobacteria,1RNAK@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q protein possibly involved in aromatic compounds catabolism yigI GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - 4HBT k59_1354079_1 330214.NIDE2574 1.56e-103 313.0 COG0138@1|root,COG0138@2|Bacteria,3J0CV@40117|Nitrospirae 40117|Nitrospirae F AICARFT/IMPCHase bienzyme purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_1354084_1 488538.SAR116_1464 6.98e-14 75.1 COG0730@1|root,COG0730@2|Bacteria,1MWAN@1224|Proteobacteria,2TS4X@28211|Alphaproteobacteria,4BQXK@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_29130_1 656519.Halsa_0352 1.78e-62 204.0 COG0686@1|root,COG0686@2|Bacteria,1TNZ5@1239|Firmicutes,2489D@186801|Clostridia,3WBBG@53433|Halanaerobiales 186801|Clostridia C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_29188_2 78245.Xaut_0552 2.34e-25 99.4 COG1396@1|root,COG1396@2|Bacteria,1ND0I@1224|Proteobacteria,2UIAT@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional Regulator, XRE family - - - - - - - - - - - - HTH_3 k59_29217_1 1122134.KB893650_gene859 1.89e-141 419.0 COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria,1XICD@135619|Oceanospirillales 135619|Oceanospirillales C Cytochrome D1 heme domain - - 1.7.2.1,1.7.99.1 ko:K15864 ko00910,ko01120,map00910,map01120 M00529 R00143,R00783,R00785 RC00086,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_D1,Cytochrome_CBB3 k59_29239_1 1333998.M2A_2590 1.07e-59 191.0 2C6CV@1|root,33W8F@2|Bacteria,1RM05@1224|Proteobacteria,2U9CX@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_29338_1 99598.Cal7507_1099 4.26e-23 97.8 COG1028@1|root,COG1028@2|Bacteria,1G0MD@1117|Cyanobacteria,1HIHK@1161|Nostocales 1117|Cyanobacteria IQ PFAM Short-chain dehydrogenase reductase SDR fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_29338_2 498761.HM1_2164 0.00022 43.9 COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,247UF@186801|Clostridia 186801|Clostridia I malonyl coa-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_29444_2 1123392.AQWL01000009_gene1047 6.95e-25 105.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2VQB1@28216|Betaproteobacteria,1KS9W@119069|Hydrogenophilales 119069|Hydrogenophilales S Rhomboid family - - - - - - - - - - - - Rhomboid k59_29446_1 671143.DAMO_2460 4.51e-66 226.0 COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2NQFC@2323|unclassified Bacteria 2|Bacteria GJM Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III mpg - 1.6.5.5,2.7.7.13,5.4.2.10,5.4.2.2,5.4.2.8 ko:K00344,ko:K00966,ko:K01840,ko:K03431,ko:K15778,ko:K16881 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00361,M00362 R00885,R00959,R01057,R01818,R02060,R08639 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3178 Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III k59_29449_1 469371.Tbis_0097 1.14e-16 84.3 COG0515@1|root,COG0515@2|Bacteria,2GM6E@201174|Actinobacteria,4E449@85010|Pseudonocardiales 201174|Actinobacteria KLT Protein tyrosine kinase pkaB - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_29496_1 1227349.C170_19127 1.68e-15 79.3 COG0664@1|root,COG0664@2|Bacteria,1TVBM@1239|Firmicutes,4HEJG@91061|Bacilli,26UAS@186822|Paenibacillaceae 91061|Bacilli K cAMP-binding protein crp2 - - ko:K10914,ko:K21562 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_29559_1 330214.NIDE2773 3.57e-31 114.0 COG0521@1|root,COG0521@2|Bacteria 2|Bacteria H Mo-molybdopterin cofactor metabolic process moaB - 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_29658_1 1235796.C815_00548 8.41e-10 64.3 COG3774@1|root,COG3774@2|Bacteria,1V3YG@1239|Firmicutes 1239|Firmicutes M COG3774 Mannosyltransferase OCH1 and related enzymes - - - - - - - - - - - - Caps_synth,Gly_transf_sug k59_29688_1 234267.Acid_0594 1.12e-35 132.0 COG0823@1|root,COG0823@2|Bacteria,3Y36H@57723|Acidobacteria 57723|Acidobacteria U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 k59_29936_1 177437.HRM2_25060 1.53e-112 330.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42NME@68525|delta/epsilon subdivisions,2WJ4A@28221|Deltaproteobacteria,2MJ1K@213118|Desulfobacterales 28221|Deltaproteobacteria E Branched-chain amino acid transport system / permease component livH - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_30032_1 1229909.NSED_02835 6.27e-109 317.0 COG0580@1|root,arCOG04431@2157|Archaea,41S5R@651137|Thaumarchaeota 651137|Thaumarchaeota G Major Intrinsic Protein - - - ko:K06188,ko:K09866 ko04962,ko04976,map04962,map04976 - - - ko00000,ko00001,ko02000 1.A.8 - - MIP k59_30144_1 1123320.KB889574_gene5707 3.48e-72 232.0 COG0148@1|root,COG0148@2|Bacteria,2GJAY@201174|Actinobacteria 201174|Actinobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_30537_1 395961.Cyan7425_0821 9.51e-66 217.0 COG1696@1|root,COG1696@2|Bacteria,1FZXB@1117|Cyanobacteria,3KHWG@43988|Cyanothece 1117|Cyanobacteria M MBOAT, membrane-bound O-acyltransferase family - - - ko:K19294 - - - - ko00000 - - - MBOAT k59_30622_1 95619.PM1_0217670 3.51e-05 48.1 COG3355@1|root,COG3355@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - EIIA-man,HWE_HK,PAS_4,PRD,Sigma54_activat k59_30793_1 998088.B565_0004 7.1e-72 236.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1Y43E@135624|Aeromonadales 135624|Aeromonadales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_30876_2 1207063.P24_04010 3.58e-144 417.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TT26@28211|Alphaproteobacteria,2JPYZ@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the binding-protein-dependent transport system permease family - - - - - - - - - - - - BPD_transp_2 k59_30931_1 162425.CADANIAP00008215 3.23e-47 166.0 COG0006@1|root,2QPUH@2759|Eukaryota,3AIHQ@33154|Opisthokonta,3PBMG@4751|Fungi,3R0WY@4890|Ascomycota,20AI4@147545|Eurotiomycetes,3SC6D@5042|Eurotiales 4751|Fungi E Creatinase/Prolidase N-terminal domain - - - - - - - - - - - - Creatinase_N,Peptidase_M24 k59_30931_2 43228.XP_007732386.1 5.52e-14 72.0 COG1028@1|root,KOG0725@2759|Eukaryota,39TUM@33154|Opisthokonta,3P0TD@4751|Fungi,3QR0N@4890|Ascomycota,20F54@147545|Eurotiomycetes,3MRFI@451870|Chaetothyriomycetidae 4751|Fungi Q Glucose 1-dehydrogenase - - - - - - - - - - - - DUF1989,Polysacc_deac_1 k59_31050_1 331869.BAL199_26721 1.39e-95 292.0 COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,2TSXR@28211|Alphaproteobacteria,4BPWW@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S VWA domain containing CoxE-like protein MA20_09405 - - ko:K07161 - - - - ko00000 - - - VWA_CoxE k59_31075_1 1054213.HMPREF9946_05115 1.08e-25 110.0 COG1208@1|root,COG1208@2|Bacteria 2|Bacteria JM COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon - - - - - - - - - - - - APH,NTP_transf_3,NTP_transferase k59_31215_2 1265313.HRUBRA_00036 3.92e-14 69.7 COG0517@1|root,COG0517@2|Bacteria 2|Bacteria S IMP dehydrogenase activity - - - ko:K04767,ko:K07168,ko:K07182 - - - - ko00000 - - - CBS k59_31277_1 1382306.JNIM01000001_gene1895 1.97e-59 193.0 COG1478@1|root,COG1478@2|Bacteria,2G5TU@200795|Chloroflexi 200795|Chloroflexi S TIGRFAM F420-dependent oxidoreductase - - 6.3.2.31,6.3.2.34 ko:K12234 ko00680,ko01120,map00680,map01120 M00378 R09399,R09400 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000 - - - F420_ligase k59_31340_1 472759.Nhal_0847 4.84e-60 191.0 COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,1RPMV@1236|Gammaproteobacteria,1WWM4@135613|Chromatiales 135613|Chromatiales H Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol coq7 - - ko:K06134 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00128 R04984,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 - - - COQ7 k59_31341_1 644966.Tmar_2181 3.21e-87 274.0 COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,248CR@186801|Clostridia,3WD01@538999|Clostridiales incertae sedis 186801|Clostridia F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_31458_1 1385935.N836_19630 1.27e-44 161.0 COG0405@1|root,COG0405@2|Bacteria,1G20A@1117|Cyanobacteria,1H8BE@1150|Oscillatoriales 1117|Cyanobacteria E PFAM Gamma-glutamyltranspeptidase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_31478_1 1299327.I546_2830 8.79e-213 593.0 COG0683@1|root,COG0683@2|Bacteria,2IAAV@201174|Actinobacteria,234EA@1762|Mycobacteriaceae 201174|Actinobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - - - - - - - - - - Peripla_BP_6 k59_31478_2 216594.MMAR_4322 8.35e-80 251.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,234H1@1762|Mycobacteriaceae 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_31709_1 1229909.NSED_05130 3.18e-28 108.0 COG0159@1|root,arCOG01086@2157|Archaea,41SG0@651137|Thaumarchaeota 651137|Thaumarchaeota E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_31709_2 436308.Nmar_0915 1.6e-61 199.0 COG0133@1|root,arCOG01433@2157|Archaea,41S87@651137|Thaumarchaeota 651137|Thaumarchaeota E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_31877_1 765869.BDW_04175 4.74e-11 66.6 COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,42QZE@68525|delta/epsilon subdivisions,2MUHI@213481|Bdellovibrionales,2WS8W@28221|Deltaproteobacteria 213481|Bdellovibrionales S Membrane - - - ko:K08988 - - - - ko00000 - - - TPM_phosphatase k59_31904_1 1121434.AULY01000010_gene2328 6.43e-108 332.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2WJXY@28221|Deltaproteobacteria,2M826@213115|Desulfovibrionales 28221|Deltaproteobacteria C TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit sdhA - 1.3.5.1,1.3.5.4 ko:K00239,ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_31914_1 258052.JNYV01000002_gene792 1.69e-19 90.5 COG0300@1|root,COG0300@2|Bacteria,2I8RA@201174|Actinobacteria 201174|Actinobacteria S PFAM Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short k59_32095_1 130081.XP_005703222.1 4.03e-09 60.1 COG0576@1|root,KOG3003@2759|Eukaryota 2759|Eukaryota O adenyl-nucleotide exchange factor activity mge1 GO:0000166,GO:0000774,GO:0001405,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005744,GO:0005759,GO:0006457,GO:0006605,GO:0006626,GO:0006790,GO:0006810,GO:0006839,GO:0006886,GO:0006996,GO:0007005,GO:0008104,GO:0008150,GO:0008152,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016226,GO:0017038,GO:0017076,GO:0019866,GO:0022607,GO:0030150,GO:0030234,GO:0030554,GO:0031090,GO:0031163,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0036094,GO:0042026,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044571,GO:0044743,GO:0045184,GO:0046907,GO:0050790,GO:0051082,GO:0051179,GO:0051186,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0060589,GO:0060590,GO:0065002,GO:0065007,GO:0065009,GO:0070013,GO:0070585,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0072594,GO:0072655,GO:0097159,GO:0098772,GO:0098796,GO:0098798,GO:0098800,GO:1901265,GO:1901363,GO:1990542 - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_32095_2 485915.Dret_1082 3.68e-60 200.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,2M8Q4@213115|Desulfovibrionales 28221|Deltaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_32099_1 693977.Deipr_2526 1.13e-11 69.3 COG0389@1|root,COG0389@2|Bacteria,1WKFJ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_32134_1 404589.Anae109_2487 7.26e-24 98.2 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2WJ7R@28221|Deltaproteobacteria,2YWJD@29|Myxococcales 28221|Deltaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_32158_1 1265503.KB905166_gene680 4.33e-18 84.3 COG1597@1|root,COG1597@2|Bacteria,1MY37@1224|Proteobacteria,1RMX9@1236|Gammaproteobacteria 1224|Proteobacteria I the in vivo substrate is - - - - - - - - - - - - DAGK_cat k59_32261_1 1122194.AUHU01000005_gene1085 2.49e-30 117.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,464UF@72275|Alteromonadaceae 1236|Gammaproteobacteria E chorismate mutase pheA - 4.2.1.51,5.4.99.5 ko:K04518,ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_32261_2 1504981.KO116_2605 3.71e-32 122.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1XIJ6@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_32288_1 748247.AZKH_p0163 1.99e-91 288.0 COG1018@1|root,COG3894@1|root,COG1018@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,2VZBE@28216|Betaproteobacteria 28216|Betaproteobacteria C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445,Fer2 k59_32408_1 671143.DAMO_2631 4.31e-18 87.8 COG1463@1|root,COG1463@2|Bacteria,2NPXJ@2323|unclassified Bacteria 2|Bacteria Q MlaD protein ttg2C - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_32427_1 1415780.JPOG01000001_gene2508 1.56e-51 183.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria,1SMN0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_685297_1 472759.Nhal_0657 4.25e-97 291.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1WWXU@135613|Chromatiales 135613|Chromatiales EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_685297_2 1163617.SCD_n00821 1.92e-29 116.0 COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2VHHT@28216|Betaproteobacteria 28216|Betaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_685297_3 983545.Glaag_3060 2.4e-73 228.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria,4645F@72275|Alteromonadaceae 1236|Gammaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_1468121_2 91464.S7335_2376 2.27e-19 90.1 COG2199@1|root,COG3920@1|root,COG3706@2|Bacteria,COG3920@2|Bacteria,1GQ3J@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase - - - - - - - - - - - - CHASE2,GAF,GGDEF,HAMP,HATPase_c,HisKA_2,Response_reg,dCache_1 k59_527271_1 991905.SL003B_3826 8.76e-82 269.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria,4BPQH@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Putative amidoligase enzyme (DUF2126) MA20_16195 - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_1468122_1 1121434.AULY01000011_gene1799 2.94e-48 171.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2WJ9G@28221|Deltaproteobacteria,2M7Z9@213115|Desulfovibrionales 28221|Deltaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_840884_1 1283300.ATXB01000001_gene1711 2.53e-96 307.0 COG1554@1|root,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,1RPN6@1236|Gammaproteobacteria 1236|Gammaproteobacteria G hydrolase family 65, central catalytic ycjT GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0016787,GO:0030312,GO:0044464,GO:0071944 2.4.1.64,3.2.1.28,5.4.2.6 ko:K01194,ko:K01838,ko:K04844,ko:K05342 ko00500,ko01100,map00500,map01100 - R00010,R02727,R02728,R11310 RC00049,RC00408 ko00000,ko00001,ko00537,ko01000 - GH37,GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2 k59_213960_1 335283.Neut_0771 3.13e-75 233.0 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2WGXF@28216|Betaproteobacteria,372AF@32003|Nitrosomonadales 28216|Betaproteobacteria M PFAM Peptidase M48 - - - - - - - - - - - - Peptidase_M48 k59_997250_1 1305737.JAFX01000001_gene2212 4.37e-50 180.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,47K8C@768503|Cytophagia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family bepE_4 - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_422981_1 1255043.TVNIR_3409 3.61e-68 221.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1WX4Z@135613|Chromatiales 135613|Chromatiales S AI-2E family transporter - - - ko:K03548 - - - - ko00000,ko02000 2.A.86.1 - - AI-2E_transport k59_1571873_1 436308.Nmar_0412 5.94e-125 363.0 COG1052@1|root,arCOG01755@2157|Archaea,41T1D@651137|Thaumarchaeota 651137|Thaumarchaeota C D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.26 ko:K00015 ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120 - R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_685317_1 886293.Sinac_6536 5.61e-69 234.0 COG0567@1|root,COG0567@2|Bacteria,2IWRF@203682|Planctomycetes 203682|Planctomycetes C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1260021_2 269797.Mbar_A0261 1.52e-36 139.0 COG1331@1|root,arCOG02007@2157|Archaea,2XU5Q@28890|Euryarchaeota,2N91Y@224756|Methanomicrobia 224756|Methanomicrobia O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_1518334_1 1054213.HMPREF9946_05054 1.43e-39 143.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2TQNE@28211|Alphaproteobacteria,2JPV4@204441|Rhodospirillales 204441|Rhodospirillales H Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_1363247_2 1211114.ALIP01000084_gene1678 7.28e-17 79.7 COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,1S64Q@1236|Gammaproteobacteria,1X691@135614|Xanthomonadales 135614|Xanthomonadales S competence protein comF - - - - - - - - - - - Pribosyltran k59_527296_1 880073.Calab_1598 5.13e-08 55.5 COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria 2|Bacteria P Prokaryotic cytochrome b561 cbcY - - - - - - - - - - - Cytochrom_c3_2,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese k59_1154258_1 696747.NIES39_A04370 2.53e-69 225.0 COG0306@1|root,COG0306@2|Bacteria 2|Bacteria P phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_579695_1 349521.HCH_00294 6.17e-120 356.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1XH3Y@135619|Oceanospirillales 135619|Oceanospirillales E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_475120_1 1380394.JADL01000009_gene3178 1.5e-54 184.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,2JPTH@204441|Rhodospirillales 204441|Rhodospirillales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_475120_2 287.DR97_3268 1.32e-15 77.0 2E3RZ@1|root,32YPK@2|Bacteria,1NJYT@1224|Proteobacteria,1SHP1@1236|Gammaproteobacteria,1YJNR@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1260052_1 574966.KB898646_gene2858 5.09e-22 99.4 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1XHCB@135619|Oceanospirillales 135619|Oceanospirillales T Belongs to the PEP-utilizing enzyme family ptsP - 2.7.3.9 ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_789846_1 1380394.JADL01000011_gene3911 1.42e-96 300.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,2JV59@204441|Rhodospirillales 204441|Rhodospirillales EQ Hydantoinase B/oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_318963_1 1167006.UWK_02336 1.88e-41 146.0 COG3366@1|root,COG3366@2|Bacteria,1NEIQ@1224|Proteobacteria,42P9X@68525|delta/epsilon subdivisions,2WM1E@28221|Deltaproteobacteria,2MHVZ@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Nucleoside recognition - - - - - - - - - - - - - k59_318963_2 1121434.AULY01000007_gene1519 4.27e-13 63.9 COG1141@1|root,COG1141@2|Bacteria,1NIQZ@1224|Proteobacteria,42WTV@68525|delta/epsilon subdivisions,2WSPT@28221|Deltaproteobacteria,2MD3D@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K05337 - - - - ko00000 - - - Fer4_13 k59_1049894_1 1229909.NSED_02800 1e-75 235.0 COG1465@1|root,arCOG04353@2157|Archaea,41S88@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis aroB' - 1.4.1.24 ko:K11646 ko00400,ko01110,ko01130,map00400,map01110,map01130 - R08569 RC02302 ko00000,ko00001,ko01000 - - - DHQS k59_1049894_2 436308.Nmar_0551 2.21e-15 73.2 COG0169@1|root,arCOG02097@2157|Archaea,41SKU@651137|Thaumarchaeota 651137|Thaumarchaeota E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate aroD - 4.2.1.10 ko:K03785 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_I k59_1260066_1 1163617.SCD_n01209 4.53e-98 310.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.6 ko:K21307 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1468196_1 1144275.COCOR_02121 3.46e-06 55.8 COG1520@1|root,COG1572@1|root,COG1520@2|Bacteria,COG1572@2|Bacteria,1QX45@1224|Proteobacteria,42YA1@68525|delta/epsilon subdivisions,2WTP9@28221|Deltaproteobacteria 28221|Deltaproteobacteria M cell adhesion involved in biofilm formation - - - - - - - - - - - - HYR,VCBS k59_997300_1 158190.SpiGrapes_0721 6.52e-22 97.8 COG1744@1|root,COG1744@2|Bacteria,2J9Q4@203691|Spirochaetes 203691|Spirochaetes M ABC-type transport system, periplasmic component surface lipoprotein - - - ko:K07335 - - - - ko00000 - - - Bmp k59_1415472_1 1033802.SSPSH_001412 1.33e-30 117.0 28NA5@1|root,2ZBDZ@2|Bacteria,1MXY5@1224|Proteobacteria,1S45N@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_160236_1 502025.Hoch_4684 8.03e-126 401.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,42Q75@68525|delta/epsilon subdivisions,2WMDY@28221|Deltaproteobacteria,2YU11@29|Myxococcales 28221|Deltaproteobacteria L DEAD DEAH box - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_423025_2 1114970.PSF113_0819 5.21e-11 64.7 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RSGI@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1233 Phytoene dehydrogenase and related proteins - - - - - - - - - - - - Amino_oxidase,DAO,NAD_binding_8 k59_1571912_1 279714.FuraDRAFT_2524 1.63e-156 486.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2VI8X@28216|Betaproteobacteria 28216|Betaproteobacteria L DEAD DEAH box helicase lhr - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_1154290_1 1489678.RDMS_01870 1.98e-58 196.0 COG0160@1|root,COG0160@2|Bacteria,1WITZ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family argD - 2.6.1.19 ko:K00823 ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1415474_1 1168065.DOK_15069 3.1e-97 296.0 COG2141@1|root,COG2141@2|Bacteria,1R7K1@1224|Proteobacteria,1RNSC@1236|Gammaproteobacteria,1J5HQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_579729_2 1210884.HG799465_gene12230 9.82e-31 120.0 COG4965@1|root,COG4965@2|Bacteria,2IYKD@203682|Planctomycetes 203682|Planctomycetes U type II secretion system protein - - - ko:K12510 - - - - ko00000,ko02044 - - - T2SSF k59_685381_1 1279017.AQYJ01000021_gene2871 5.77e-13 70.5 COG4942@1|root,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,1RR11@1236|Gammaproteobacteria,466TP@72275|Alteromonadaceae 1236|Gammaproteobacteria D COG0739 Membrane proteins related to metalloendopeptidases nlpD GO:0000920,GO:0001896,GO:0005575,GO:0005623,GO:0008150,GO:0008219,GO:0009279,GO:0009987,GO:0012501,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0043085,GO:0044093,GO:0044462,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071944 - ko:K06194,ko:K12943 - - - - ko00000 1.A.34.1.2 - - LysM,Peptidase_M23 k59_685381_2 985867.AEWF01000001_gene1887 3.45e-23 95.9 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2TVCY@28211|Alphaproteobacteria,47F9X@766|Rickettsiales 766|Rickettsiales O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_318986_1 880073.Calab_3608 7.47e-104 319.0 COG0471@1|root,COG0471@2|Bacteria,2NPNA@2323|unclassified Bacteria 2|Bacteria P Sodium:sulfate symporter transmembrane region sdcS GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0034220,GO:0044425,GO:0051179,GO:0051234,GO:0055085,GO:0098656 - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_944997_1 395964.KE386496_gene361 4.12e-21 93.6 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria,3NCIH@45404|Beijerinckiaceae 28211|Alphaproteobacteria H 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_1260095_1 1121035.AUCH01000004_gene429 3.18e-85 293.0 COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria 1224|Proteobacteria I CoA-substrate-specific enzyme activase - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_633301_1 886293.Sinac_7397 7.78e-104 315.0 COG1861@1|root,COG1861@2|Bacteria,2J3F7@203682|Planctomycetes 203682|Planctomycetes M PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_4 k59_1310904_1 1142394.PSMK_10580 6.95e-70 239.0 COG3264@1|root,COG3264@2|Bacteria,2IY5W@203682|Planctomycetes 203682|Planctomycetes M COG3264 Small-conductance mechanosensitive channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel,MscS_TM,MscS_porin k59_1102249_1 1207063.P24_01941 1.92e-45 162.0 COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2TS48@28211|Alphaproteobacteria,2JRFE@204441|Rhodospirillales 204441|Rhodospirillales G COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_58656_1 580332.Slit_1795 0.000216 42.0 COG3114@1|root,COG3114@2|Bacteria 2|Bacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmD GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678 - ko:K02196 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.107 - iB21_1397.B21_02084,iBWG_1329.BWG_1971,iE2348C_1286.E2348C_2342,iEC042_1314.EC042_2439,iEC55989_1330.EC55989_2451,iECABU_c1320.ECABU_c25320,iECBD_1354.ECBD_1462,iECB_1328.ECB_02125,iECDH10B_1368.ECDH10B_2355,iECDH1ME8569_1439.ECDH1ME8569_2133,iECD_1391.ECD_02125,iECED1_1282.ECED1_2663,iECH74115_1262.ECH74115_3335,iECIAI1_1343.ECIAI1_2280,iECIAI39_1322.ECIAI39_2336,iECNA114_1301.ECNA114_2290,iECO103_1326.ECO103_2673,iECO111_1330.ECO111_2934,iECO26_1355.ECO26_3124,iECOK1_1307.ECOK1_2432,iECP_1309.ECP_2238,iECS88_1305.ECS88_2345,iECSE_1348.ECSE_2466,iECSF_1327.ECSF_2079,iECSP_1301.ECSP_3077,iECUMN_1333.ECUMN_2533,iECs_1301.ECs3087,iEKO11_1354.EKO11_1558,iETEC_1333.ETEC_2332,iEcDH1_1363.EcDH1_1461,iEcE24377_1341.EcE24377A_2497,iEcHS_1320.EcHS_A2336,iEcSMS35_1347.EcSMS35_2346,iEcolC_1368.EcolC_1452,iJO1366.b2198,iLF82_1304.LF82_0276,iNRG857_1313.NRG857_11155,iSDY_1059.SDY_0880,iSFV_1184.SFV_2274,iSF_1195.SF2282,iSSON_1240.SSON_2256,iS_1188.S2412,iUMN146_1321.UM146_05815,iUMNK88_1353.UMNK88_2745,iUTI89_1310.UTI89_C2476,iY75_1357.Y75_RS11500,iZ_1308.Z3455,ic_1306.c2735 CcmD k59_58656_2 1333998.M2A_0751 2.26e-31 118.0 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2TSW8@28211|Alphaproteobacteria,4BPH8@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm k59_475182_1 243231.GSU1193 3.12e-32 122.0 COG0191@1|root,COG0191@2|Bacteria,1NMAK@1224|Proteobacteria,42NPW@68525|delta/epsilon subdivisions,2WIMN@28221|Deltaproteobacteria,43T4V@69541|Desulfuromonadales 28221|Deltaproteobacteria G Fructose-bisphosphate aldolase class-II - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_527354_2 1121374.KB891575_gene1049 1.09e-42 144.0 COG0346@1|root,COG0346@2|Bacteria,1Q6YP@1224|Proteobacteria,1SHXX@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase k59_840975_1 7719.XP_002123904.1 3.07e-05 50.4 KOG0406@1|root,KOG0406@2759|Eukaryota,38D3D@33154|Opisthokonta,3BJ5E@33208|Metazoa,3CXTB@33213|Bilateria,48233@7711|Chordata 33208|Metazoa O glutathione dehydrogenase (ascorbate) activity GSTO1 GO:0000302,GO:0003674,GO:0003824,GO:0004364,GO:0004734,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005604,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005739,GO:0005829,GO:0005975,GO:0005996,GO:0006082,GO:0006518,GO:0006575,GO:0006725,GO:0006726,GO:0006728,GO:0006732,GO:0006749,GO:0006766,GO:0006767,GO:0006790,GO:0006805,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0006937,GO:0006942,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0007166,GO:0007204,GO:0008016,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009110,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010033,GO:0010522,GO:0010523,GO:0010524,GO:0010646,GO:0010647,GO:0010648,GO:0010880,GO:0010881,GO:0010882,GO:0010959,GO:0012505,GO:0014722,GO:0014809,GO:0014810,GO:0014819,GO:0015036,GO:0015037,GO:0015038,GO:0016020,GO:0016051,GO:0016053,GO:0016209,GO:0016491,GO:0016645,GO:0016648,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0016782,GO:0018130,GO:0019221,GO:0019438,GO:0019722,GO:0019725,GO:0019748,GO:0019752,GO:0019852,GO:0019853,GO:0019889,GO:0019932,GO:0022898,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030003,GO:0030424,GO:0030613,GO:0030614,GO:0031012,GO:0031090,GO:0031965,GO:0031967,GO:0031975,GO:0032259,GO:0032409,GO:0032410,GO:0032411,GO:0032412,GO:0032413,GO:0032414,GO:0032879,GO:0033218,GO:0034097,GO:0034641,GO:0034762,GO:0034763,GO:0034764,GO:0034765,GO:0034766,GO:0034767,GO:0035556,GO:0035722,GO:0042178,GO:0042221,GO:0042277,GO:0042364,GO:0042440,GO:0042441,GO:0042558,GO:0042559,GO:0042592,GO:0042802,GO:0042803,GO:0042995,GO:0043005,GO:0043167,GO:0043168,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043269,GO:0043270,GO:0043271,GO:0043295,GO:0043324,GO:0043436,GO:0043473,GO:0043474,GO:0043603,GO:0044057,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044297,GO:0044421,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045174,GO:0045933,GO:0045989,GO:0046148,GO:0046364,GO:0046394,GO:0046483,GO:0046685,GO:0046983,GO:0048037,GO:0048066,GO:0048069,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0048878,GO:0050610,GO:0050789,GO:0050794,GO:0050801,GO:0050848,GO:0050849,GO:0050850,GO:0050896,GO:0051049,GO:0051050,GO:0051051,GO:0051186,GO:0051188,GO:0051239,GO:0051240,GO:0051279,GO:0051280,GO:0051281,GO:0051282,GO:0051284,GO:0051480,GO:0051716,GO:0051924,GO:0051926,GO:0051928,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055114,GO:0055117,GO:0060314,GO:0060315,GO:0060316,GO:0060341,GO:0062023,GO:0065007,GO:0065008,GO:0065009,GO:0070671,GO:0070887,GO:0071243,GO:0071310,GO:0071345,GO:0071349,GO:0071466,GO:0071704,GO:0072341,GO:0072503,GO:0072507,GO:0090257,GO:0097237,GO:0097458,GO:0098754,GO:0098771,GO:0098869,GO:0120025,GO:1900750,GO:1901019,GO:1901020,GO:1901021,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1901685,GO:1901687,GO:1901700,GO:1902531,GO:1902532,GO:1902533,GO:1903169,GO:1903170,GO:1903522,GO:1904062,GO:1904063,GO:1904064,GO:1904427,GO:1990748,GO:2001257,GO:2001258,GO:2001259 1.5.4.1,2.5.1.18 ko:K00310,ko:K00799 ko00480,ko00790,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00790,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R03984,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00011,RC00069,RC00840,RC00948,RC01043,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_C_3,GST_N_3 k59_789916_1 1545915.JROG01000001_gene437 3.98e-18 86.7 COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria,2K1IW@204457|Sphingomonadales 204457|Sphingomonadales H glutamate--cysteine ligase - - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - GCS2 k59_423064_1 1182590.BN5_03850 5.2e-07 57.4 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1YDIH@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Putative nucleotidyltransferase substrate binding domain - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_423064_2 757424.Hsero_2383 2.16e-18 85.1 COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,2VJIQ@28216|Betaproteobacteria,475ZM@75682|Oxalobacteraceae 28216|Betaproteobacteria L DNA polymerase X family - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP k59_633326_1 298655.KI912266_gene5892 8.31e-25 103.0 COG1309@1|root,COG1309@2|Bacteria,2IAMN@201174|Actinobacteria,4EVV6@85013|Frankiales 201174|Actinobacteria K PFAM regulatory protein TetR - - - - - - - - - - - - TetR_N k59_475189_1 330214.NIDE0736 4.22e-45 162.0 COG0558@1|root,COG1208@1|root,COG0558@2|Bacteria,COG1208@2|Bacteria 2|Bacteria JM COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon - - 2.7.7.99 ko:K00992 ko00520,ko01100,map00520,map01100 - R11025 RC00002 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_997347_1 1048339.KB913029_gene805 1.96e-07 56.6 COG0778@1|root,COG0778@2|Bacteria,2ISFU@201174|Actinobacteria 201174|Actinobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_997347_2 909663.KI867151_gene3099 3.36e-111 337.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42QX5@68525|delta/epsilon subdivisions,2WJVI@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Belongs to the thiolase family - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_1102262_1 999541.bgla_1g38360 6.68e-52 183.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,1K1PV@119060|Burkholderiaceae 28216|Betaproteobacteria LU DNA protecting protein DprA smf - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_319013_1 411901.BACCAC_01336 7.82e-19 87.4 COG1554@1|root,COG1554@2|Bacteria,4NG60@976|Bacteroidetes,2FQZD@200643|Bacteroidia,4ANKH@815|Bacteroidaceae 976|Bacteroidetes G COG NOG04001 non supervised orthologous group - - 3.2.1.51 ko:K15923 ko00511,map00511 - - - ko00000,ko00001,ko01000 - GH95 - - k59_475190_1 330214.NIDE0903 5.95e-103 303.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 k59_1624468_1 436308.Nmar_0623 7.9e-93 280.0 arCOG08741@1|root,arCOG08741@2157|Archaea,41SWQ@651137|Thaumarchaeota 651137|Thaumarchaeota E CAAX protease self-immunity - - - - - - - - - - - - Abi k59_475889_1 909663.KI867150_gene1775 2.24e-79 251.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions,2WKF2@28221|Deltaproteobacteria,2MQN5@213462|Syntrophobacterales 28221|Deltaproteobacteria I PLD-like domain - - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_371490_1 1232410.KI421421_gene3451 2.01e-74 233.0 COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,42SXH@68525|delta/epsilon subdivisions,2WP5D@28221|Deltaproteobacteria,43TCA@69541|Desulfuromonadales 28221|Deltaproteobacteria C Malate/L-lactate dehydrogenase - - 1.1.1.338 ko:K16844 ko00270,ko01120,map00270,map01120 - R07137 RC00031 ko00000,ko00001,ko01000 - - - Ldh_2 k59_894107_1 1278073.MYSTI_02939 7.04e-07 48.9 COG0432@1|root,COG0432@2|Bacteria,1RA5G@1224|Proteobacteria,42QZ8@68525|delta/epsilon subdivisions,2WMV9@28221|Deltaproteobacteria,2YUYA@29|Myxococcales 28221|Deltaproteobacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_894107_2 1499689.CCNN01000015_gene3471 0.000183 47.4 COG1623@1|root,COG1623@2|Bacteria,1TQD8@1239|Firmicutes,247J4@186801|Clostridia,36DQY@31979|Clostridiaceae 186801|Clostridia L Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation disA - 2.7.7.85 ko:K07067 - - - - ko00000,ko01000 - - - DisA-linker,DisA_N,HHH,HHH_2 k59_634228_1 981384.AEYW01000001_gene1602 3.21e-19 90.5 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_634228_2 1385517.N800_08785 6.04e-106 336.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,1X9HA@135614|Xanthomonadales 135614|Xanthomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1363995_1 322710.Avin_33130 7.3e-19 91.7 COG2109@1|root,COG4206@1|root,COG2109@2|Bacteria,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB btuB GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015267,GO:0015318,GO:0015889,GO:0015893,GO:0016020,GO:0016021,GO:0019904,GO:0022803,GO:0022838,GO:0022857,GO:0031224,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705 - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - iECB_1328.ECB_03851,iECP_1309.ECP_4183,iSF_1195.SF4048,iS_1188.S3696 Plug,TonB_dep_Rec k59_580454_1 159087.Daro_1559 6.12e-40 152.0 COG2206@1|root,COG2206@2|Bacteria,1QWUX@1224|Proteobacteria,2VZ70@28216|Betaproteobacteria 28216|Betaproteobacteria T HD domain - - - - - - - - - - - - HD_5,PAS_4 k59_1108935_1 1434325.AZQN01000003_gene2401 5e-07 51.2 2C85M@1|root,334CZ@2|Bacteria,4NSRZ@976|Bacteroidetes,47SET@768503|Cytophagia 976|Bacteroidetes S Stress responsive A/B Barrel Domain - - - - - - - - - - - - Dabb k59_692589_1 644282.Deba_0280 8.48e-56 193.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Penicillin-binding protein 2 mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_0928 PBP_dimer,Transpeptidase k59_692598_1 1502851.FG93_00182 1.92e-67 234.0 COG0642@1|root,COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1 k59_586266_1 1210045.ALNP01000009_gene4806 1.63e-13 73.2 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria 201174|Actinobacteria KLT serine threonine protein kinase pknL GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_586266_2 1122175.ATXU01000007_gene82 3.63e-11 65.1 COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4FKVU@85023|Microbacteriaceae 201174|Actinobacteria T Protein of unknown function (DUF2662) fhaA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 - - - - - - - - - - DUF3662,FHA,Yop-YscD_cpl k59_900001_2 457425.XNR_3454 4.17e-34 130.0 COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_220723_1 44060.JODL01000011_gene2035 3.48e-19 92.0 COG0300@1|root,COG0596@1|root,COG0300@2|Bacteria,COG0596@2|Bacteria,2I2RM@201174|Actinobacteria 201174|Actinobacteria I Belongs to the short-chain dehydrogenases reductases (SDR) family ephD - - - - - - - - - - - Abhydrolase_1,adh_short k59_533854_1 580340.Tlie_0897 4.26e-17 84.0 COG0215@1|root,COG0215@2|Bacteria,3TAAB@508458|Synergistetes 508458|Synergistetes J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e k59_533854_2 1278073.MYSTI_03024 4.26e-21 92.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2WJ20@28221|Deltaproteobacteria,2YU4B@29|Myxococcales 28221|Deltaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_67240_1 380358.XALC_2543 1.38e-10 64.7 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1X3NH@135614|Xanthomonadales 135614|Xanthomonadales U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_67240_2 644968.DFW101_1691 3.63e-26 104.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria,2M9N8@213115|Desulfovibrionales 28221|Deltaproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_847540_1 95619.PM1_0204735 1.68e-65 215.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria 1236|Gammaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_115541_1 439235.Dalk_3879 5.77e-84 267.0 COG5421@1|root,COG5421@2|Bacteria,1R7NE@1224|Proteobacteria,42M25@68525|delta/epsilon subdivisions,2WKHV@28221|Deltaproteobacteria,2MJVY@213118|Desulfobacterales 28221|Deltaproteobacteria L IMG reference gene - - - - - - - - - - - - DDE_Tnp_1 k59_1316920_1 1265503.KB905160_gene2616 3.15e-23 92.4 COG2963@1|root,COG2963@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07483 - - - - ko00000 - - - HTH_28,HTH_Tnp_1 k59_1316920_2 864069.MicloDRAFT_00063290 2.8e-11 63.5 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,1JQUR@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_742799_1 330214.NIDE0325 2.11e-136 399.0 COG1236@1|root,COG1236@2|Bacteria,3J0FD@40117|Nitrospirae 40117|Nitrospirae J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_742799_2 1117647.M5M_17755 2.19e-20 89.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1S032@1236|Gammaproteobacteria,1J586@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_798822_1 204669.Acid345_4164 5.29e-22 92.8 COG2010@1|root,COG2010@2|Bacteria,3Y5Q0@57723|Acidobacteria 57723|Acidobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_220752_1 330214.NIDE3554 2.56e-05 45.4 COG0596@1|root,COG0596@2|Bacteria 2|Bacteria S hydrolase activity, acting on ester bonds pcaD - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_220752_2 1328313.DS2_07958 1.11e-33 129.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,465ZV@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase rarA GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_273104_2 323261.Noc_2341 5.83e-219 616.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1WWCI@135613|Chromatiales 135613|Chromatiales O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_273104_3 1094715.CM001373_gene2501 2.23e-93 276.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1JDWB@118969|Legionellales 118969|Legionellales O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_273104_4 748247.AZKH_1017 1.89e-69 219.0 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2VRBQ@28216|Betaproteobacteria,2KW1M@206389|Rhodocyclales 206389|Rhodocyclales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain msrQ - - ko:K17247 - - - - ko00000 - - - Ferric_reduct k59_798846_1 1268635.Loa_01510 1.23e-63 217.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1JCH1@118969|Legionellales 118969|Legionellales I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain yfcX - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_482891_1 203122.Sde_1225 7.8e-75 233.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,1RZ5Q@1236|Gammaproteobacteria,46767@72275|Alteromonadaceae 1236|Gammaproteobacteria S membrane protein (homolog of Drosophila rhomboid) - - - - - - - - - - - - Rhomboid k59_1476617_1 436308.Nmar_0656 8.84e-13 72.4 COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota 651137|Thaumarchaeota T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,dCache_1 k59_1476617_2 436308.Nmar_0199 4.87e-39 131.0 arCOG10519@1|root,arCOG10519@2157|Archaea,41T6D@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_798854_1 445686.E3SL89_9CAUD 4.82e-109 321.0 4QAR1@10239|Viruses,4QUNA@35237|dsDNA viruses no RNA stage,4QPJE@28883|Caudovirales,4QI9Y@10662|Myoviridae 10662|Myoviridae S ATPase family associated with various cellular activities (AAA) - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_1476622_1 56780.SYN_02999 3.21e-79 236.0 COG0432@1|root,COG0432@2|Bacteria,1RA5G@1224|Proteobacteria,42QZ8@68525|delta/epsilon subdivisions,2WMV9@28221|Deltaproteobacteria,2MRJM@213462|Syntrophobacterales 28221|Deltaproteobacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_1476622_2 404589.Anae109_2754 1.4e-07 53.5 COG1148@1|root,COG1148@2|Bacteria,1PTJ7@1224|Proteobacteria,42NJN@68525|delta/epsilon subdivisions,2WJHG@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_6 k59_429739_1 1229909.NSED_01270 3.62e-68 214.0 COG5016@1|root,arCOG02095@2157|Archaea,41SKA@651137|Thaumarchaeota 651137|Thaumarchaeota C Biotin-requiring enzyme - - - ko:K18605 ko00720,ko01120,map00720,map01120 - R00742,R01859 RC00040,RC00097,RC00367,RC00609 ko00000,ko00001 - - - Biotin_lipoyl k59_429739_2 436308.Nmar_0275 8.72e-98 285.0 COG1225@1|root,arCOG00310@2157|Archaea,41SKG@651137|Thaumarchaeota 651137|Thaumarchaeota O Redoxin - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_951511_1 1123399.AQVE01000009_gene3101 3.27e-57 200.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,46034@72273|Thiotrichales 72273|Thiotrichales U TIGRFAM type IV pilus secretin (or competence protein) PilQ pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_325844_1 247634.GPB2148_549 1.31e-14 80.1 COG1073@1|root,COG1073@2|Bacteria,1PQAX@1224|Proteobacteria,1S02C@1236|Gammaproteobacteria,1J81R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S alpha beta - - - - - - - - - - - - DUF2048 k59_273805_2 946483.Cenrod_0502 1.31e-33 129.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2VHBY@28216|Betaproteobacteria,4A9JC@80864|Comamonadaceae 28216|Betaproteobacteria E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1269556_1 640081.Dsui_1568 5.49e-45 155.0 COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,2VJS2@28216|Betaproteobacteria,2KW6H@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit - - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_483922_1 391615.ABSJ01000024_gene268 1.84e-47 160.0 COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,1SASJ@1236|Gammaproteobacteria,1JBWJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Smr domain - - - - - - - - - - - - Smr k59_642872_1 7918.ENSLOCP00000007372 2.1e-05 53.9 KOG3544@1|root,KOG3544@2759|Eukaryota,38VI7@33154|Opisthokonta,3BGWK@33208|Metazoa,3CYC6@33213|Bilateria,480X0@7711|Chordata,496HI@7742|Vertebrata,49YB6@7898|Actinopterygii 33208|Metazoa W Collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase COLQ GO:0001505,GO:0001507,GO:0001941,GO:0003674,GO:0005198,GO:0005488,GO:0005539,GO:0005575,GO:0005576,GO:0005604,GO:0005605,GO:0005615,GO:0005623,GO:0005886,GO:0006581,GO:0006807,GO:0007154,GO:0007267,GO:0007268,GO:0007271,GO:0007528,GO:0008104,GO:0008150,GO:0008152,GO:0008201,GO:0008291,GO:0008582,GO:0009056,GO:0009987,GO:0010817,GO:0016020,GO:0016043,GO:0017144,GO:0023052,GO:0030054,GO:0031012,GO:0031594,GO:0033036,GO:0034613,GO:0040008,GO:0042133,GO:0042135,GO:0042445,GO:0042447,GO:0042737,GO:0043113,GO:0043167,GO:0043168,GO:0044087,GO:0044237,GO:0044248,GO:0044420,GO:0044421,GO:0044464,GO:0045184,GO:0045202,GO:0048638,GO:0050789,GO:0050793,GO:0050794,GO:0050803,GO:0050807,GO:0050808,GO:0051128,GO:0051179,GO:0051234,GO:0051239,GO:0051641,GO:0051668,GO:0051960,GO:0051963,GO:0061024,GO:0062023,GO:0065007,GO:0065008,GO:0070727,GO:0071340,GO:0071704,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0097164,GO:0097367,GO:0098916,GO:0099173,GO:0099536,GO:0099537,GO:1900619,GO:1901575,GO:1901681,GO:1904396,GO:2000026 - - - - - - - - - - Collagen,DUF4215 k59_483924_1 395493.BegalDRAFT_2869 4.61e-54 182.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria,45ZRP@72273|Thiotrichales 72273|Thiotrichales S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_693435_1 1005048.CFU_1656 6.56e-74 235.0 COG1752@1|root,COG1752@2|Bacteria,1MVHW@1224|Proteobacteria,2VH3I@28216|Betaproteobacteria,4743X@75682|Oxalobacteraceae 28216|Betaproteobacteria S Esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_534735_1 626887.J057_17550 3.1e-56 183.0 COG3839@1|root,COG3839@2|Bacteria,1QXG5@1224|Proteobacteria,1T3B9@1236|Gammaproteobacteria 1236|Gammaproteobacteria G ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran k59_534735_2 62928.azo1315 1.82e-50 168.0 COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,2VJX0@28216|Betaproteobacteria,2KXZK@206389|Rhodocyclales 206389|Rhodocyclales S Uncharacterised protein family (UPF0014) - - - ko:K02069 - M00211 - - ko00000,ko00002,ko02000 9.B.25.1 - - UPF0014 k59_743629_1 1144310.PMI07_006478 1.9e-60 199.0 COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2U84X@28211|Alphaproteobacteria,4BF68@82115|Rhizobiaceae 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - 3.7.1.18 ko:K20765 - - - - ko00000,ko01000 - - - ECH_1 k59_743629_2 247633.GP2143_03323 9.34e-05 45.8 COG4221@1|root,COG4221@2|Bacteria,1QTXD@1224|Proteobacteria,1T1MG@1236|Gammaproteobacteria,1J8AB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short k59_1317489_1 1434929.X946_678 7.57e-40 151.0 COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHAU@28216|Betaproteobacteria,1KFC2@119060|Burkholderiaceae 28216|Betaproteobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - DUF4384,PEGA,Pkinase k59_1317489_2 472759.Nhal_1973 3.18e-60 194.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,1WY2P@135613|Chromatiales 135613|Chromatiales J catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_900760_1 2074.JNYD01000022_gene1445 5.29e-34 122.0 2BZ0R@1|root,2Z7U0@2|Bacteria,2GU1J@201174|Actinobacteria,4E1EN@85010|Pseudonocardiales 201174|Actinobacteria S PFAM Nitrile hydratase, alpha subunit Thiocyanate hydrolase, gamma subunit - - 4.2.1.84 ko:K01721 ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120 - R02828,R04020,R05379,R05596,R07780,R07854 RC00483,RC00792,RC01345,RC01432 ko00000,ko00001,ko01000 - - - NHase_alpha k59_900760_2 118173.KB235914_gene748 2.92e-22 90.5 2E0AM@1|root,32VXZ@2|Bacteria,1G7Z3@1117|Cyanobacteria,1HFP2@1150|Oscillatoriales 1117|Cyanobacteria S Nitrile hydratase beta subunit - - - - - - - - - - - - NHase_beta k59_483934_1 1123401.JHYQ01000047_gene163 2.25e-26 100.0 COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,1S1Z9@1236|Gammaproteobacteria,460J9@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione gloA - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_534745_1 313606.M23134_03337 2.67e-49 167.0 COG1028@1|root,COG1028@2|Bacteria,4NEUB@976|Bacteroidetes,47MT3@768503|Cytophagia 976|Bacteroidetes IQ KR domain - - 1.3.1.25 ko:K05783 ko00362,ko00364,ko00622,ko01100,ko01120,ko01220,map00362,map00364,map00622,map01100,map01120,map01220 M00551 R00813,R05292,R05293,R05309,R05314,R08111,R08112,R08113 RC00271,RC01326,RC01327 br01602,ko00000,ko00001,ko00002,ko01000 - - - adh_short_C2 k59_1632246_1 251221.35211627 4.76e-23 99.4 COG4671@1|root,COG4671@2|Bacteria,1G0CT@1117|Cyanobacteria 1117|Cyanobacteria S PFAM Glycosyltransferase family 28 C-terminal domain - - - - - - - - - - - - Glyco_tran_28_C k59_1632246_2 1173026.Glo7428_2226 1.75e-19 87.8 COG0438@1|root,COG0438@2|Bacteria,1G14V@1117|Cyanobacteria 1117|Cyanobacteria M PFAM Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_2,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_1477593_1 1121948.AUAC01000002_gene876 8.16e-14 69.3 COG0800@1|root,COG0800@2|Bacteria,1MUVJ@1224|Proteobacteria,2TUMH@28211|Alphaproteobacteria,43XRN@69657|Hyphomonadaceae 28211|Alphaproteobacteria G COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase - - 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 - - - Aldolase k59_326628_1 1229909.NSED_04245 5.61e-19 84.0 arCOG08714@1|root,arCOG08714@2157|Archaea,41SPW@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_326628_2 1229909.NSED_04240 1.29e-43 142.0 arCOG10546@1|root,arCOG10546@2157|Archaea,41SRD@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_430377_1 76114.ebA6835 1.5e-20 92.8 COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2VI8B@28216|Betaproteobacteria,2KVFH@206389|Rhodocyclales 206389|Rhodocyclales O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress - - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 k59_799823_1 999550.KI421507_gene3372 1.51e-22 94.7 COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,2UF72@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein affecting phage T7 exclusion by the F plasmid fxsA - - ko:K07113 - - - - ko00000 - - - FxsA k59_799823_2 1260251.SPISAL_00625 1.64e-28 106.0 COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,1SCFM@1236|Gammaproteobacteria,1WYXG@135613|Chromatiales 135613|Chromatiales P Divalent ion tolerance protein - - - ko:K03926 - - - - ko00000 - - - CutA1 k59_799823_3 1123392.AQWL01000006_gene695 5.8e-22 97.4 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,1KS2S@119069|Hydrogenophilales 119069|Hydrogenophilales CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps - - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_1109740_1 1283300.ATXB01000001_gene845 7.32e-12 67.8 COG1215@1|root,COG1215@2|Bacteria,1MW1E@1224|Proteobacteria,1RZY2@1236|Gammaproteobacteria,1XGAD@135618|Methylococcales 135618|Methylococcales M Glycosyl transferase family 21 - - - - - - - - - - - - - k59_1109740_2 323261.Noc_1745 1.66e-16 79.3 COG0535@1|root,COG0535@2|Bacteria,1MXM1@1224|Proteobacteria,1RNQ1@1236|Gammaproteobacteria,1X06Z@135613|Chromatiales 135613|Chromatiales S Radical SAM domain - - - - - - - - - - - - DUF3463,Radical_SAM k59_483967_1 582744.Msip34_0493 8.91e-73 226.0 COG0842@1|root,COG0842@2|Bacteria,1MUF4@1224|Proteobacteria,2W3RW@28216|Betaproteobacteria,2KNNH@206350|Nitrosomonadales 206350|Nitrosomonadales V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_1477612_1 113355.CM001775_gene2509 0.000247 47.0 COG1716@1|root,COG1716@2|Bacteria,1G6Y2@1117|Cyanobacteria 1117|Cyanobacteria T (FHA) domain - - - - - - - - - - - - FHA k59_743651_1 1348657.M622_18510 4.74e-39 145.0 COG4227@1|root,COG4227@2|Bacteria,1MU8I@1224|Proteobacteria,2VMTV@28216|Betaproteobacteria,2KZ44@206389|Rhodocyclales 206389|Rhodocyclales L Domain of unknown function (DUF1738) - - - - - - - - - - - - DUF1738 k59_167253_2 243090.RB1103 3.03e-117 355.0 COG0769@1|root,COG0769@2|Bacteria 2|Bacteria M UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity murE - 6.3.2.13 ko:K01928,ko:K01932 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1160812_1 1229909.NSED_00180 1.37e-90 283.0 COG0443@1|root,arCOG03060@2157|Archaea,41SCM@651137|Thaumarchaeota 651137|Thaumarchaeota O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1160812_2 1229909.NSED_00175 6.93e-26 100.0 COG0576@1|root,arCOG04772@2157|Archaea,41SSU@651137|Thaumarchaeota 651137|Thaumarchaeota O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ - - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_430389_1 395961.Cyan7425_1329 5.14e-31 115.0 COG1309@1|root,COG1309@2|Bacteria,1G5IR@1117|Cyanobacteria 1117|Cyanobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1424090_1 90813.JQMT01000001_gene1113 3.28e-69 220.0 COG0657@1|root,COG0657@2|Bacteria,1N2XW@1224|Proteobacteria,1RRAQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria I esterase lipase - - - - - - - - - - - - Abhydrolase_3,Peptidase_S9 k59_1004682_1 1382306.JNIM01000001_gene574 2.15e-14 77.8 COG1502@1|root,COG1502@2|Bacteria,2G7KK@200795|Chloroflexi 200795|Chloroflexi I PFAM phospholipase D Transphosphatidylase - - - - - - - - - - - - PLDc_2 k59_693499_1 502025.Hoch_2050 7.25e-83 263.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,42MA8@68525|delta/epsilon subdivisions,2WIXR@28221|Deltaproteobacteria,2YUA9@29|Myxococcales 28221|Deltaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_1424121_1 998674.ATTE01000001_gene2058 4.27e-59 200.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,45ZPV@72273|Thiotrichales 72273|Thiotrichales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_68323_1 1121918.ARWE01000001_gene1155 4.75e-32 127.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,42PCH@68525|delta/epsilon subdivisions,2WMQM@28221|Deltaproteobacteria,43TBC@69541|Desulfuromonadales 28221|Deltaproteobacteria M 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) kdtA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_N k59_855111_2 330214.NIDE4045 3.14e-43 142.0 COG1977@1|root,COG1977@2|Bacteria 2|Bacteria H Mo-molybdopterin cofactor metabolic process moaD - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_387432_1 1232447.BAHW02000034_gene2495 2.71e-32 123.0 COG0796@1|root,COG0796@2|Bacteria,1TPPR@1239|Firmicutes,249MB@186801|Clostridia,268TM@186813|unclassified Clostridiales 186801|Clostridia M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_958630_1 1121939.L861_07930 1.29e-59 202.0 COG1234@1|root,COG1234@2|Bacteria,1PPRD@1224|Proteobacteria,1RRV8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Beta-lactamase superfamily domain rnz - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - CLP1_P,Lactamase_B,Lactamase_B_2 k59_855119_1 99598.Cal7507_5960 1.07e-27 114.0 COG5002@1|root,COG5002@2|Bacteria,1G25Q@1117|Cyanobacteria,1HJ95@1161|Nostocales 1117|Cyanobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_541099_1 522772.Dacet_1268 1.17e-53 181.0 COG0772@1|root,COG0772@2|Bacteria,2GF50@200930|Deferribacteres 200930|Deferribacteres M Peptidoglycan polymerase that is essential for cell wall elongation rodA - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_651565_1 314225.ELI_14900 4.26e-95 285.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2K2F6@204457|Sphingomonadales 204457|Sphingomonadales L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve,rve_3 k59_1011360_1 1384056.N787_13720 2.64e-26 103.0 COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,1SDD5@1236|Gammaproteobacteria,1X6IQ@135614|Xanthomonadales 135614|Xanthomonadales S Uncharacterized ACR, COG1430 - - - ko:K09005 - - - - ko00000 - - - DUF192 k59_750217_1 667014.Thein_1529 3.3e-24 94.7 2EAFJ@1|root,334IY@2|Bacteria,2GHZR@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Domain of unknown function (DUF1844) - - - - - - - - - - - - DUF1844 k59_750217_2 903818.KI912268_gene2138 2.35e-08 55.5 COG0789@1|root,COG0789@2|Bacteria,3Y4KX@57723|Acidobacteria 57723|Acidobacteria K PFAM regulatory protein, MerR - - - ko:K13640 - - - - ko00000,ko03000 - - - MerR_1 k59_750217_3 642492.Clole_2130 4.64e-19 88.6 COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia 186801|Clostridia O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1278573_1 1453501.JELR01000001_gene3194 2.49e-39 144.0 COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,1SEDW@1236|Gammaproteobacteria,46943@72275|Alteromonadaceae 1236|Gammaproteobacteria O PPIC-type PPIASE domain - - - - - - - - - - - - Rotamase_2 k59_907502_1 502025.Hoch_3215 1.56e-69 226.0 COG0204@1|root,COG0204@2|Bacteria,1N01J@1224|Proteobacteria,42UM7@68525|delta/epsilon subdivisions,2WQN9@28221|Deltaproteobacteria,2Z3CW@29|Myxococcales 28221|Deltaproteobacteria I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase k59_333237_1 509635.N824_01560 5.81e-12 70.9 COG0642@1|root,COG2461@1|root,COG3829@1|root,COG2205@2|Bacteria,COG2461@2|Bacteria,COG3829@2|Bacteria 2|Bacteria T transcription factor binding - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - DUF2249,GAF,GAF_2,HATPase_c,HATPase_c_2,HisKA,HisKA_2,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1165975_2 1408422.JHYF01000001_gene2738 4.78e-27 102.0 2E6IF@1|root,3315M@2|Bacteria,1VAX0@1239|Firmicutes,24N55@186801|Clostridia,36KEX@31979|Clostridiaceae 186801|Clostridia - - ortA GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 2.3.1.263 ko:K21399 - - - - ko00000,ko01000 - - - - k59_1165975_3 555079.Toce_1489 1.06e-29 115.0 COG3804@1|root,COG3804@2|Bacteria,1TRNF@1239|Firmicutes,249AS@186801|Clostridia,42G7Z@68295|Thermoanaerobacterales 186801|Clostridia C Dihydrodipicolinate reductase, N-terminus - - 1.4.1.12,1.4.1.26 ko:K21672 ko00310,ko00330,ko00472,map00310,map00330,map00472 - R02825,R04200,R04201,R04687,R04688 RC00249,RC00790 ko00000,ko00001,ko01000 - - - DapB_N k59_855141_1 1380391.JIAS01000015_gene169 2.84e-44 159.0 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TUMK@28211|Alphaproteobacteria,2JPB1@204441|Rhodospirillales 204441|Rhodospirillales E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_907511_1 1266914.ATUK01000015_gene883 2.21e-74 239.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1WXA3@135613|Chromatiales 135613|Chromatiales U General secretion pathway protein F - - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_387495_1 511062.GU3_15850 7.06e-42 155.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1Y6KX@135624|Aeromonadales 135624|Aeromonadales P Sulfate permease family - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_1639262_2 856793.MICA_280 2.65e-33 137.0 COG3378@1|root,COG4951@1|root,COG3378@2|Bacteria,COG4951@2|Bacteria,1MV7I@1224|Proteobacteria,2TRS2@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Phage plasmid primase P4 family - - - ko:K06919 - - - - ko00000 - - - D5_N,Pox_D5 k59_492703_1 1123257.AUFV01000003_gene989 4.27e-19 87.8 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1X30N@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_492703_2 452637.Oter_3821 1.07e-20 86.3 COG2331@1|root,COG2331@2|Bacteria,46T2S@74201|Verrucomicrobia 74201|Verrucomicrobia S Putative regulatory protein - - - - - - - - - - - - Zn-ribbon_8 k59_1486337_1 1120963.KB894493_gene2915 5.3e-70 225.0 COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,1RMZV@1236|Gammaproteobacteria,2Q182@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria O OsmC-like protein - - - ko:K06889,ko:K07397 - - - - ko00000 - - - Hydrolase_4,OsmC k59_280794_1 999541.bgla_1g36330 4.92e-11 59.3 COG2963@1|root,COG2963@2|Bacteria,1RIC2@1224|Proteobacteria,2VTGY@28216|Betaproteobacteria 28216|Betaproteobacteria L Transposase - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_280794_2 1247963.JPHU01000019_gene2998 4.52e-49 164.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria 1224|Proteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_1639281_1 1077144.AGFF01000005_gene2224 3.78e-09 63.5 COG0627@1|root,COG5479@1|root,COG0627@2|Bacteria,COG5479@2|Bacteria,2H37X@201174|Actinobacteria 201174|Actinobacteria M Esterase csp1 - - - - - - - - - - - Esterase,LGFP k59_173071_1 1123368.AUIS01000016_gene2527 2.28e-61 203.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,2NCEA@225057|Acidithiobacillales 225057|Acidithiobacillales M Lipoprotein releasing system transmembrane protein LolC - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_808756_1 1038858.AXBA01000023_gene408 1.66e-09 57.8 COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,3EYGT@335928|Xanthobacteraceae 28211|Alphaproteobacteria H Ketopantoate reductase PanE/ApbA C terminal panE - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_808756_2 648885.KB316283_gene3352 1.32e-67 220.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TW3C@28211|Alphaproteobacteria,1JR1I@119045|Methylobacteriaceae 28211|Alphaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_1585992_1 861299.J421_2742 1.01e-91 291.0 COG1138@1|root,COG1138@2|Bacteria,1ZTBY@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Cytochrome c-type biogenesis protein CcmF C-terminal - - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_76989_1 1541065.JRFE01000057_gene6262 8.88e-25 101.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_25,Methyltransf_31,Ubie_methyltran k59_1011405_1 1033802.SSPSH_002589 1.22e-129 377.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria 1236|Gammaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_1527863_1 177437.HRM2_16600 1.47e-104 318.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MJ8N@213118|Desulfobacterales 28221|Deltaproteobacteria C Respiratory-chain NADH dehydrogenase domain 51 kDa subunit - - 1.12.1.3,1.6.5.2,1.6.5.3 ko:K00124,ko:K00335,ko:K00355,ko:K18331 ko00130,ko00190,ko00630,ko00680,ko01100,ko01110,ko01120,ko01200,ko05200,ko05225,ko05418,map00130,map00190,map00630,map00680,map01100,map01110,map01120,map01200,map05200,map05225,map05418 M00144 R00519,R02964,R03643,R03816,R11945 RC00061,RC00819,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_593727_1 479434.Sthe_0735 1.04e-21 96.3 COG4263@1|root,COG4263@2|Bacteria,2G8B2@200795|Chloroflexi,27YVK@189775|Thermomicrobia 189775|Thermomicrobia C nitrous-oxide reductase activity - - 1.7.2.4 ko:K00376 ko00910,ko01120,map00910,map01120 M00529 R02804 RC02861 ko00000,ko00001,ko00002,ko01000 - - - - k59_593727_2 269799.Gmet_0328 3.42e-20 90.5 COG2010@1|root,COG2863@1|root,COG2010@2|Bacteria,COG2863@2|Bacteria,1MYNE@1224|Proteobacteria,437HK@68525|delta/epsilon subdivisions,2WVN9@28221|Deltaproteobacteria 28221|Deltaproteobacteria C cytochrome c - - - - - - - - - - - iAF987.Gmet_0328 Cytochrom_C k59_907532_1 983545.Glaag_1426 1.23e-89 288.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,464IG@72275|Alteromonadaceae 1236|Gammaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_4,DNA_pol3_tau_5 k59_1377032_1 330214.NIDE0409 9.74e-66 211.0 COG0547@1|root,COG0547@2|Bacteria,3J17P@40117|Nitrospirae 40117|Nitrospirae E Glycosyl transferase family, a/b domain - - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_1377033_1 324057.Pjdr2_0376 4.01e-39 142.0 COG1230@1|root,COG1230@2|Bacteria,1TR92@1239|Firmicutes,4HBCQ@91061|Bacilli,26QAH@186822|Paenibacillaceae 91061|Bacilli P cation diffusion facilitator family transporter czcD - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux,ZT_dimer k59_1432698_1 316067.Geob_2168 3.17e-31 119.0 COG2203@1|root,COG2203@2|Bacteria,1RJ35@1224|Proteobacteria,42T0K@68525|delta/epsilon subdivisions,2WPIM@28221|Deltaproteobacteria,43T60@69541|Desulfuromonadales 28221|Deltaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF_3 k59_1432698_2 269799.Gmet_2302 1.05e-06 48.5 COG2199@1|root,COG3706@2|Bacteria,1N0N3@1224|Proteobacteria,43CGB@68525|delta/epsilon subdivisions,2X60G@28221|Deltaproteobacteria,43W37@69541|Desulfuromonadales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_125130_1 1121924.ATWH01000025_gene1363 8.59e-14 70.1 COG0492@1|root,COG0492@2|Bacteria,2GIXN@201174|Actinobacteria,4FMYR@85023|Microbacteriaceae 201174|Actinobacteria O Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Methyltransf_23,Methyltransf_25,Pyr_redox_2 k59_1527872_1 425104.Ssed_1657 3.02e-17 77.0 2DJ8V@1|root,3050U@2|Bacteria,1RE7U@1224|Proteobacteria,1SNMT@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - - k59_541145_1 472759.Nhal_2126 3.05e-20 95.1 COG1501@1|root,COG1501@2|Bacteria,1MWNJ@1224|Proteobacteria,1RMJ9@1236|Gammaproteobacteria,1WXTR@135613|Chromatiales 135613|Chromatiales G Belongs to the glycosyl hydrolase 31 family - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31 k59_1432707_1 639030.JHVA01000001_gene937 2.13e-06 51.2 COG1228@1|root,COG1228@2|Bacteria,3Y539@57723|Acidobacteria,2JKT2@204432|Acidobacteriia 204432|Acidobacteriia Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_387566_1 583355.Caka_0784 3.62e-156 458.0 COG0326@1|root,COG0326@2|Bacteria,46U76@74201|Verrucomicrobia,3K7PC@414999|Opitutae 414999|Opitutae O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c_3,HSP90 k59_1278670_1 330214.NIDE2737 4.69e-71 231.0 COG0465@1|root,COG0465@2|Bacteria,3J0AG@40117|Nitrospirae 40117|Nitrospirae D Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_907545_1 311402.Avi_1042 1.69e-43 154.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2TRD8@28211|Alphaproteobacteria,4B7CQ@82115|Rhizobiaceae 28211|Alphaproteobacteria O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_125139_1 794903.OPIT5_23160 7.86e-27 112.0 COG1999@1|root,COG1999@2|Bacteria,46W2T@74201|Verrucomicrobia,3K80B@414999|Opitutae 414999|Opitutae S Copper binding periplasmic protein CusF - - - ko:K07152 - - - - ko00000,ko03029 - - - CusF_Ec,SCO1-SenC k59_1586027_2 756272.Plabr_2853 7.92e-63 211.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2IXH6@203682|Planctomycetes 203682|Planctomycetes C Pyruvate ferredoxin oxidoreductase and related - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1527884_2 1121875.KB907546_gene2238 1.03e-16 78.6 COG1409@1|root,COG1409@2|Bacteria,4NFAP@976|Bacteroidetes,1I2DE@117743|Flavobacteriia 976|Bacteroidetes S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos,PA14 k59_387588_1 882378.RBRH_03317 5.81e-28 112.0 COG2912@1|root,COG2912@2|Bacteria,1MVJQ@1224|Proteobacteria,2VMIR@28216|Betaproteobacteria,1K17Z@119060|Burkholderiaceae 28216|Betaproteobacteria S Transglutaminase-like superfamily - - - - - - - - - - - - TPR_9,Transglut_core2 k59_1486422_1 1121875.KB907548_gene1616 1.56e-81 263.0 COG1529@1|root,COG1529@2|Bacteria,4NFFU@976|Bacteroidetes,1HXJS@117743|Flavobacteriia 976|Bacteroidetes C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_651702_1 1122212.AULO01000008_gene1332 3.17e-140 408.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,1RQKU@1236|Gammaproteobacteria,1XJ2M@135619|Oceanospirillales 135619|Oceanospirillales E Aminotransferase class-III - - 2.6.1.76 ko:K00836 ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230 M00033 R06977 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_651702_2 765911.Thivi_0467 6.16e-33 124.0 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1WVWS@135613|Chromatiales 135613|Chromatiales T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH - 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - - Metallophos k59_1377055_1 765914.ThisiDRAFT_2322 1.06e-85 266.0 COG0591@1|root,COG0591@2|Bacteria,1N8H2@1224|Proteobacteria,1RR54@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_387593_1 1047013.AQSP01000057_gene1923 3.31e-89 290.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - Sortilin-Vps10 k59_808836_1 1468179.A0A0C4K3Z2_9VIRU 6e-70 224.0 4QBAP@10239|Viruses 10239|Viruses S transferase activity - - - - - - - - - - - - - k59_1278707_1 1322246.BN4_12523 5.22e-29 111.0 COG1664@1|root,COG1664@2|Bacteria,1N7TF@1224|Proteobacteria,42VWZ@68525|delta/epsilon subdivisions,2WRPF@28221|Deltaproteobacteria,2MBWU@213115|Desulfovibrionales 28221|Deltaproteobacteria M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin k59_700229_1 502025.Hoch_2090 3.8e-19 92.0 COG3488@1|root,COG3488@2|Bacteria,1MXUW@1224|Proteobacteria,42YAW@68525|delta/epsilon subdivisions,2WTPQ@28221|Deltaproteobacteria,2YU9D@29|Myxococcales 28221|Deltaproteobacteria C Di-haem oxidoreductase, putative peroxidase - - - - - - - - - - - - DHOR k59_1278710_1 314278.NB231_11574 8.6e-19 82.8 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,1WWF1@135613|Chromatiales 135613|Chromatiales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_1278710_2 1049564.TevJSym_bh00220 5.46e-57 182.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,1J4UQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0131 Imidazoleglycerol-phosphate dehydratase hisB GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 ko:K01089,ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013,R03457 RC00017,RC00932 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iUMNK88_1353.UMNK88_2570 Hydrolase_like,IGPD,PNK3P k59_855217_1 83406.HDN1F_21110 3.24e-90 273.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1J4PJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the TrpC family trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0422 IGPS k59_492832_2 314278.NB231_11129 7.01e-14 73.9 COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RNJY@1236|Gammaproteobacteria,1WZTH@135613|Chromatiales 135613|Chromatiales H HemX, putative uroporphyrinogen-III C-methyltransferase - - 2.1.1.107 ko:K02496 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000 - - - HemX k59_1166040_1 1298880.AUEV01000014_gene3851 2e-100 310.0 COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - 1.17.1.9,1.6.5.3 ko:K00122,ko:K00335 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_1377077_1 765913.ThidrDRAFT_0075 9.53e-66 225.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales 135613|Chromatiales OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1586801_1 497321.C664_10243 1.58e-27 107.0 COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2VQ7P@28216|Betaproteobacteria,2KW5B@206389|Rhodocyclales 206389|Rhodocyclales S Cobalamin adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_1012219_1 269799.Gmet_2454 3.31e-14 77.0 COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,43C4K@68525|delta/epsilon subdivisions,2X7F1@28221|Deltaproteobacteria,43TX3@69541|Desulfuromonadales 28221|Deltaproteobacteria T Domains HisKA, HATPase_c - - - - - - - - - - - - HATPase_c,HisKA k59_1651284_1 472759.Nhal_0174 2.27e-109 322.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,1WW7W@135613|Chromatiales 135613|Chromatiales E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_820631_1 159749.K0RZY4 1.16e-10 66.6 2E66K@1|root,2SCXS@2759|Eukaryota,2XH3A@2836|Bacillariophyta 2759|Eukaryota S Kazal type serine protease inhibitors - - - - - - - - - - - - Kazal_1 k59_1384925_1 1121405.dsmv_1387 1.21e-98 306.0 COG0477@1|root,COG0477@2|Bacteria,1MWUR@1224|Proteobacteria,43BPW@68525|delta/epsilon subdivisions,2X714@28221|Deltaproteobacteria,2MPJ0@213118|Desulfobacterales 28221|Deltaproteobacteria EGP PFAM major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_1 k59_1498079_1 1304888.ATWF01000001_gene1038 9.85e-64 209.0 COG0281@1|root,COG0281@2|Bacteria,2GF34@200930|Deferribacteres 200930|Deferribacteres C Malic enzyme, N-terminal domain - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic k59_1384929_1 243231.GSU2862 4.64e-82 273.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_290058_1 1183438.GKIL_4044 2.77e-28 116.0 COG1641@1|root,COG1641@2|Bacteria,1G14X@1117|Cyanobacteria 1117|Cyanobacteria S Belongs to the LarC family - - 4.99.1.12 ko:K09121 - - - - ko00000,ko01000 - - - DUF111 k59_1073513_1 713587.THITH_14630 1.61e-35 130.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1WXKK@135613|Chromatiales 135613|Chromatiales P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_549462_1 472759.Nhal_3354 8.61e-99 301.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1WXMI@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_3,HlyD_D23 k59_916848_1 1206731.BAGB01000167_gene973 1.38e-38 146.0 COG2079@1|root,COG2079@2|Bacteria,2HRSH@201174|Actinobacteria,4G96A@85025|Nocardiaceae 201174|Actinobacteria S MmgE/PrpD family - - - - - - - - - - - - MmgE_PrpD k59_290068_1 1232410.KI421426_gene1342 3.33e-71 230.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,43S03@69541|Desulfuromonadales 28221|Deltaproteobacteria J Ribonuclease E/G family cafA - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_180096_1 1123270.ATUR01000006_gene73 4.28e-13 67.4 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,2K439@204457|Sphingomonadales 204457|Sphingomonadales K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_967294_1 1156935.QWE_18749 3.38e-07 50.8 COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,2TSAI@28211|Alphaproteobacteria,4BARZ@82115|Rhizobiaceae 28211|Alphaproteobacteria O Cytochrome c biogenesis protein ccdA - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD k59_663625_2 1380394.JADL01000001_gene2859 3.32e-50 169.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2TRW7@28211|Alphaproteobacteria,2JPXB@204441|Rhodospirillales 204441|Rhodospirillales C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - ko:K19745 ko00640,ko01100,map00640,map01100 - R00919 RC00095 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_549476_1 525904.Tter_0790 1.35e-24 105.0 COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria 2|Bacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K07712,ko:K07714 ko02020,map02020 M00497,M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_549476_2 378806.STAUR_4227 5.25e-20 90.1 COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,Response_reg k59_1234378_1 685727.REQ_13820 1.54e-73 237.0 COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria,4FUVB@85025|Nocardiaceae 201174|Actinobacteria Q cytochrome P450 cyp51 GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0008398,GO:0016125,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0032451,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046906,GO:0048037,GO:0055114,GO:0070988,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901615 1.14.13.70 ko:K05917 ko00100,ko01100,ko01110,ko01130,map00100,map01100,map01110,map01130 M00101 R05640,R05731 RC01442 ko00000,ko00001,ko00002,ko00199,ko01000 - - - p450 k59_1651338_1 697282.Mettu_1034 4.43e-40 141.0 COG0558@1|root,COG0558@2|Bacteria,1N35Q@1224|Proteobacteria,1T0Q8@1236|Gammaproteobacteria,1XFBQ@135618|Methylococcales 135618|Methylococcales I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - - - - - - - - - - CDP-OH_P_transf k59_1535005_2 163908.KB235896_gene835 1.06e-07 60.5 COG0438@1|root,COG0500@1|root,COG0438@2|Bacteria,COG0500@2|Bacteria,1FZUY@1117|Cyanobacteria,1HM22@1161|Nostocales 1117|Cyanobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_2,Glyco_trans_1_4,Glyco_transf_11,Glyco_transf_4,Glyco_transf_41,Glycos_transf_1,Glycos_transf_2,Methyltransf_21,Methyltransf_23,Methyltransf_24 k59_863761_2 1333998.M2A_2516 5.14e-61 191.0 COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,2U7FW@28211|Alphaproteobacteria,4BSH4@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I MaoC like domain - - - - - - - - - - - - MaoC_dehydratas k59_1290628_1 395493.BegalDRAFT_2457 2.9e-68 216.0 COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,1SYJC@1236|Gammaproteobacteria,4607A@72273|Thiotrichales 72273|Thiotrichales EP Binding-protein-dependent transport system inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1290628_2 472759.Nhal_2856 2.73e-29 112.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1WW7F@135613|Chromatiales 135613|Chromatiales EP PFAM Binding-protein-dependent transport - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1498148_1 93059.P9211_03301 1.8e-38 146.0 COG0210@1|root,COG0210@2|Bacteria,1G17G@1117|Cyanobacteria,1MKRE@1212|Prochloraceae 1117|Cyanobacteria L Alternative locus ID pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_342307_1 1538295.JY96_20790 6.47e-82 269.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,1KJJS@119065|unclassified Burkholderiales 28216|Betaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N,IF2_assoc k59_820714_1 1395571.TMS3_0104440 8.96e-20 95.9 COG2199@1|root,COG3452@1|root,COG3452@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,GGDEF,HAMP,PAS_8,Reg_prop,dCache_1 k59_448049_1 1168059.KB899087_gene4 1.7e-32 127.0 COG3666@1|root,COG3666@2|Bacteria,1QW5T@1224|Proteobacteria,2TWNW@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase and inactivated derivatives tnp* - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_1384980_1 436308.Nmar_0690 1.07e-32 122.0 COG2519@1|root,arCOG00978@2157|Archaea,41SEF@651137|Thaumarchaeota 651137|Thaumarchaeota Q tRNA methyltransferase complex GCD14 subunit - - 2.1.1.219,2.1.1.220 ko:K07442 - - - - ko00000,ko01000,ko03016 - - - GCD14 k59_180116_2 1196324.A374_10680 5.51e-119 357.0 COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4HAWZ@91061|Bacilli 91061|Bacilli I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_180116_3 1380394.JADL01000015_gene326 4.75e-113 335.0 COG4974@1|root,COG4974@2|Bacteria,1R43B@1224|Proteobacteria,2TRTA@28211|Alphaproteobacteria,2JV44@204441|Rhodospirillales 204441|Rhodospirillales L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase k59_135217_1 1232410.KI421421_gene3661 1.26e-60 202.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WJKC@28221|Deltaproteobacteria,43SVH@69541|Desulfuromonadales 28221|Deltaproteobacteria M tail specific protease ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_1173272_1 722419.PH505_ck00190 6.63e-09 62.8 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,2PZUN@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria NU COG3419 Tfp pilus assembly protein, tip-associated adhesin PilY1 comC - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_290125_2 1267535.KB906767_gene5407 2.31e-09 64.7 COG3206@1|root,COG3206@2|Bacteria 2|Bacteria M extracellular polysaccharide biosynthetic process - - - ko:K07011 - - - - ko00000 - - - GNVR,Wzz k59_1384985_1 886379.AEWI01000062_gene2297 8.3e-19 87.8 COG2304@1|root,COG2304@2|Bacteria,4NF7Y@976|Bacteroidetes,2FN4B@200643|Bacteroidia,3XJQN@558415|Marinilabiliaceae 976|Bacteroidetes S von Willebrand factor (vWF) type A domain batB - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA,VWA_2 k59_448058_1 999541.bgla_2g29390 5.75e-29 115.0 COG1028@1|root,COG1028@2|Bacteria,1MXNY@1224|Proteobacteria,2VMME@28216|Betaproteobacteria,1K0MS@119060|Burkholderiaceae 28216|Betaproteobacteria IQ short-chain dehydrogenase - - - - - - - - - - - - adh_short_C2 k59_394993_1 565033.GACE_1865 5.44e-64 205.0 COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,246R4@183980|Archaeoglobi 183980|Archaeoglobi E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_135225_1 545264.KB898746_gene835 4.41e-71 226.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1WWZW@135613|Chromatiales 135613|Chromatiales E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_135231_1 754477.Q7C_1790 4.15e-79 260.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,45ZWK@72273|Thiotrichales 72273|Thiotrichales M TIGRFAM penicillin-binding protein, 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_1234435_1 1112217.PPL19_07526 1.82e-73 229.0 COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_0821,iECIAI1_1343.ECIAI1_0813,iECO103_1326.ECO103_0813,iECO111_1330.ECO111_0839,iECO26_1355.ECO26_0904,iECSE_1348.ECSE_0831,iECW_1372.ECW_m0833,iEKO11_1354.EKO11_3108,iEcE24377_1341.EcE24377A_0841,iSFV_1184.SFV_0761,iSSON_1240.SSON_0757,iWFL_1372.ECW_m0833,ic_1306.c0858 AAA_26 k59_1234435_2 765913.ThidrDRAFT_1678 5.18e-59 192.0 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales 135613|Chromatiales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_135238_1 159749.E7BWJ7 1.02e-99 296.0 COG0583@1|root,2S17Z@2759|Eukaryota 2759|Eukaryota K DNA-binding transcription factor activity rbcR GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - HTH_1,LysR_substrate k59_708652_1 1144275.COCOR_03319 3.91e-23 98.6 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,2YXPT@29|Myxococcales 28221|Deltaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_449032_1 402777.KB235903_gene547 1.95e-24 94.4 2BXCR@1|root,2ZVFB@2|Bacteria,1GG9S@1117|Cyanobacteria,1HGNU@1150|Oscillatoriales 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_449032_2 402777.KB235903_gene546 4.37e-19 79.7 2E9JM@1|root,333SG@2|Bacteria,1GEZC@1117|Cyanobacteria,1HG7Z@1150|Oscillatoriales 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_449032_3 1215114.BBIU01000002_gene256 6.29e-12 65.5 COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria 1236|Gammaproteobacteria M udp-glucose 4-epimerase galE - 5.1.3.2,5.1.3.5 ko:K01784,ko:K12448 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R01473,R02984 RC00289,RC00528 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_1595150_1 396588.Tgr7_0025 1.79e-74 234.0 COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MV72@1224|Proteobacteria,1RPH5@1236|Gammaproteobacteria,1WXHI@135613|Chromatiales 135613|Chromatiales C Oxidoreductase FAD-binding domain - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_89651_1 247490.KSU1_C0546 8.22e-52 184.0 COG1409@1|root,COG3204@1|root,COG1409@2|Bacteria,COG3204@2|Bacteria 2|Bacteria L pilus organization - - - ko:K02674,ko:K07004 - - - - ko00000,ko02035,ko02044 - - - Exo_endo_phos,HemolysinCabind,LTD,Laminin_G_3,Metallophos,Pur_ac_phosph_N k59_1291679_1 1454004.AW11_00566 9.1e-51 171.0 COG1392@1|root,COG1392@2|Bacteria,1MXY9@1224|Proteobacteria 1224|Proteobacteria P Phosphate transport regulator (Distant homolog of PhoU) UF78_21250 - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_1291679_2 675635.Psed_5111 8.48e-26 106.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4E0YM@85010|Pseudonocardiales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1595157_1 1125973.JNLC01000013_gene3779 1.01e-60 203.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2TUN5@28211|Alphaproteobacteria,3JVRY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Amino acid permease - - - ko:K03294,ko:K16238 - - - - ko00000,ko02000 2.A.3.2,2.A.3.5 - - AA_permease_2 k59_664684_1 352165.HMPREF7215_0122 3.51e-15 77.8 COG0465@1|root,COG0465@2|Bacteria,3T9TM@508458|Synergistetes 508458|Synergistetes O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_237322_1 1437824.BN940_02361 1.78e-14 71.6 2CB7M@1|root,31H4T@2|Bacteria,1MYWT@1224|Proteobacteria,2VSTJ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_237322_2 1123360.thalar_02888 1.97e-13 71.6 COG1145@1|root,COG1290@1|root,COG1908@1|root,COG1145@2|Bacteria,COG1290@2|Bacteria,COG1908@2|Bacteria,1QSPU@1224|Proteobacteria,2UQID@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - Cytochrome_B,FlpD k59_1535673_1 370438.PTH_0504 3.13e-94 295.0 COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,2606U@186807|Peptococcaceae 186801|Clostridia E PFAM Aminotransferase class-III argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1535673_2 56780.SYN_01696 2.3e-88 268.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2WJ64@28221|Deltaproteobacteria,2MQF5@213462|Syntrophobacterales 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_664691_1 1238182.C882_1603 4.25e-102 313.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2TRZA@28211|Alphaproteobacteria,2JPR4@204441|Rhodospirillales 204441|Rhodospirillales M Bacterial sugar transferase - - - - - - - - - - - - Bac_transf k59_664691_2 1122135.KB893134_gene3491 2.16e-179 513.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2TT6G@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_821748_1 765914.ThisiDRAFT_1155 2.91e-156 448.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales 135613|Chromatiales D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_1126756_1 234267.Acid_7147 6.44e-77 238.0 COG0714@1|root,COG0714@2|Bacteria,3Y6Z3@57723|Acidobacteria 57723|Acidobacteria S ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA_5 k59_1235427_1 331869.BAL199_03214 8.2e-48 165.0 COG0697@1|root,COG0697@2|Bacteria,1PHRI@1224|Proteobacteria,2TUAQ@28211|Alphaproteobacteria,4BQFV@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily MA20_39710 - - - - - - - - - - - EamA k59_505800_1 1499967.BAYZ01000026_gene1569 1.38e-155 455.0 COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria 2|Bacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_180781_2 445686.E3SLJ5_9CAUD 5.18e-83 251.0 4QHN9@10239|Viruses,4QX1H@35237|dsDNA viruses no RNA stage,4QU3Z@28883|Caudovirales,4QJE6@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_821783_1 479434.Sthe_2294 1.17e-06 50.1 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2G5ZQ@200795|Chloroflexi,27XZV@189775|Thermomicrobia 189775|Thermomicrobia C FAD linked oxidases, C-terminal domain - - - - - - - - - - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17 k59_821783_2 42256.RradSPS_0884 8.08e-12 66.2 COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria,4CPHP@84995|Rubrobacteria 84995|Rubrobacteria H Elongator protein 3 MiaB NifB - - 2.5.1.77 ko:K11779 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_1652478_1 526227.Mesil_2948 2.83e-12 66.6 COG2227@1|root,COG2227@2|Bacteria,1WKVH@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H C-methyltransferase C-terminal domain - - - - - - - - - - - - Methyltransf_13,Methyltransf_14,Methyltransf_23 k59_1652478_2 118163.Ple7327_1360 2.42e-23 99.4 COG2227@1|root,COG2227@2|Bacteria,1G2VI@1117|Cyanobacteria,3VMCM@52604|Pleurocapsales 1117|Cyanobacteria H C-methyltransferase C-terminal domain - - - - - - - - - - - - Methyltransf_13,Methyltransf_14,Methyltransf_23 k59_1385706_1 1279019.ARQK01000057_gene794 1.12e-43 150.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1WXP3@135613|Chromatiales 135613|Chromatiales I PFAM Phospholipid glycerol acyltransferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_18069_2 1068980.ARVW01000001_gene3882 2.53e-17 80.1 COG1028@1|root,COG1028@2|Bacteria,2GWHQ@201174|Actinobacteria,4E2SN@85010|Pseudonocardiales 201174|Actinobacteria IQ short-chain alcohol - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_768372_2 349124.Hhal_2218 6.64e-36 130.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,1WYG6@135613|Chromatiales 135613|Chromatiales M Belongs to the ompA family - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_1665732_2 1385935.N836_01405 5.22e-07 55.8 COG1226@1|root,32Y28@2|Bacteria,1G7VB@1117|Cyanobacteria,1HG2S@1150|Oscillatoriales 1117|Cyanobacteria P Ion channel - - - - - - - - - - - - Ion_trans_2 k59_518973_1 1229909.NSED_07460 4.45e-92 277.0 COG0330@1|root,arCOG01915@2157|Archaea,41SYP@651137|Thaumarchaeota 651137|Thaumarchaeota O PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7 k59_1665743_1 330214.NIDE3915 4.23e-108 325.0 COG1538@1|root,COG1538@2|Bacteria,3J19C@40117|Nitrospirae 40117|Nitrospirae MU Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - OEP k59_1029896_1 330214.NIDE3420 2.51e-83 256.0 COG0472@1|root,COG0472@2|Bacteria 2|Bacteria M phospho-N-acetylmuramoyl-pentapeptide-transferase activity - - 2.7.8.33,2.7.8.35 ko:K02851 - - R08856 RC00002 ko00000,ko01000,ko01003,ko01005 - - - CoA_binding_3,Glycos_transf_4 k59_1029896_2 330214.NIDE3421 5.71e-22 95.1 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - ko:K07011 - - - - ko00000 - - - Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1 k59_1452457_1 386456.JQKN01000010_gene655 1.66e-12 71.6 COG5276@1|root,arCOG02565@2157|Archaea 2157|Archaea O LVIVD repeat-containing protein - - - - - - - - - - - - LVIVD k59_354765_1 436308.Nmar_1226 9.75e-73 231.0 COG3794@1|root,arCOG02926@2157|Archaea,arCOG02929@2157|Archaea,41SHN@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind k59_929762_1 391600.ABRU01000043_gene2661 1.04e-25 103.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2TSYJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P ABC-type molybdate transport system, permease component modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_929762_2 215803.DB30_1633 1.78e-09 59.7 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,42MZE@68525|delta/epsilon subdivisions,2WKJB@28221|Deltaproteobacteria,2Z321@29|Myxococcales 28221|Deltaproteobacteria P Bacterial extracellular solute-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - iAF987.Gmet_0512 SBP_bac_11 k59_247674_2 323261.Noc_1438 4.17e-126 369.0 COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,1RQG2@1236|Gammaproteobacteria,1WZRU@135613|Chromatiales 135613|Chromatiales C homogentisate 1,2-dioxygenase - - 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 - - - HgmA k59_146805_1 1121405.dsmv_1845 1.81e-36 133.0 COG4195@1|root,COG4195@2|Bacteria,1MZZB@1224|Proteobacteria,42U90@68525|delta/epsilon subdivisions,2WQGX@28221|Deltaproteobacteria,2MKFP@213118|Desulfobacterales 28221|Deltaproteobacteria S Poly-gamma-glutamate hydrolase - - - - - - - - - - - - Gamma_PGA_hydro k59_1030704_1 1177154.Y5S_01713 5.78e-71 240.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,1XI5R@135619|Oceanospirillales 135619|Oceanospirillales S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16 k59_612199_1 1122599.AUGR01000007_gene1183 3.2e-15 80.9 COG3103@1|root,COG3103@2|Bacteria,1QXFZ@1224|Proteobacteria,1RPAR@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Sh3 type 3 domain protein - - - - - - - - - - - - DUF1302 k59_1246036_1 864073.HFRIS_000530 2.3e-06 56.2 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2WGJC@28216|Betaproteobacteria,473G2@75682|Oxalobacteraceae 28216|Betaproteobacteria T PFAM HAMP domain, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_354774_1 1033802.SSPSH_001113 4.51e-83 258.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - iPC815.YPO3376 Enolase_C,Enolase_N k59_1086214_1 240292.Ava_3043 2.19e-05 52.4 COG0517@1|root,COG0745@1|root,COG2202@1|root,COG4191@1|root,COG5002@1|root,COG0517@2|Bacteria,COG0745@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1G1PE@1117|Cyanobacteria,1HM9U@1161|Nostocales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CBS,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg k59_1394576_1 1335757.SPICUR_07000 6.9e-24 97.1 COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,1SD1K@1236|Gammaproteobacteria,1X17B@135613|Chromatiales 135613|Chromatiales S Tellurite resistance protein TerB - - - - - - - - - - - - TerB k59_1182992_2 330214.NIDE0057 1.24e-63 204.0 COG1858@1|root,COG1858@2|Bacteria,3J0GH@40117|Nitrospirae 40117|Nitrospirae C Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_1138221_1 196490.AUEZ01000052_gene170 6.29e-26 106.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,3JSS3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E GMC oxidoreductase MA20_44990 - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_1138221_2 1121930.AQXG01000003_gene2586 3.98e-11 64.3 COG0282@1|root,COG0282@2|Bacteria,4NFI0@976|Bacteroidetes,1IPB9@117747|Sphingobacteriia 976|Bacteroidetes C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_1030718_1 1122194.AUHU01000004_gene1242 2.79e-07 54.3 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,466DH@72275|Alteromonadaceae 1236|Gammaproteobacteria T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression dksA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_1030718_2 396588.Tgr7_2030 6.76e-07 50.4 COG2981@1|root,COG2981@2|Bacteria,1MVFT@1224|Proteobacteria,1RMQT@1236|Gammaproteobacteria,1WWYG@135613|Chromatiales 135613|Chromatiales E High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway cysZ - - ko:K06203 - - - - ko00000 - - - DnaJ,EI24 k59_190124_1 1198232.CYCME_2026 6.69e-39 147.0 COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,460M8@72273|Thiotrichales 72273|Thiotrichales M LppC putative lipoprotein - - - ko:K07121 - - - - ko00000 - - - LppC k59_520173_1 1328313.DS2_03660 1.06e-50 181.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,4662J@72275|Alteromonadaceae 1236|Gammaproteobacteria T CHASE2 - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_977640_1 1229909.NSED_09455 3.79e-82 254.0 COG0484@1|root,arCOG02846@2157|Archaea,41T1F@651137|Thaumarchaeota 651137|Thaumarchaeota O DnaJ molecular chaperone homology domain - - - - - - - - - - - - DnaJ k59_1086245_1 445686.E3SL66_9CAUD 2.61e-96 294.0 4QAJ5@10239|Viruses,4QUS9@35237|dsDNA viruses no RNA stage,4QPY5@28883|Caudovirales,4QHUT@10662|Myoviridae 10662|Myoviridae S Major capsid protein Gp23 - GO:0005575,GO:0019012,GO:0019028,GO:0044423 - - - - - - - - - - - k59_1545051_1 1120956.JHZK01000004_gene1320 1.08e-72 238.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2TRND@28211|Alphaproteobacteria,1JNP8@119043|Rhodobiaceae 28211|Alphaproteobacteria I Acetyl-coenzyme A synthetase N-terminus acsA1 - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1453222_1 330214.NIDE1304 1.2e-143 442.0 COG0086@1|root,COG0086@2|Bacteria,3J0BT@40117|Nitrospirae 40117|Nitrospirae K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_354803_2 224914.BMEII0303 9.29e-31 113.0 COG0251@1|root,COG0251@2|Bacteria,1MZ5K@1224|Proteobacteria,2U9GI@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_929804_1 748280.NH8B_1923 7.35e-58 191.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,2KQMW@206351|Neisseriales 206351|Neisseriales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane comL - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_1513495_1 59538.XP_005975270.1 2e-15 74.7 COG0197@1|root,KOG3422@2759|Eukaryota,39S31@33154|Opisthokonta,3BPN3@33208|Metazoa 33154|Opisthokonta J Ribosomal protein S3, C-terminal domain mrpl16 GO:0000048,GO:0000313,GO:0000315,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0003824,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019843,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0097159,GO:0098798,GO:0140053,GO:0140096,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - - - - - - - - - - Ribosomal_L16 k59_1513495_2 1335757.SPICUR_08245 2.87e-17 75.1 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,1WZ6K@135613|Chromatiales 135613|Chromatiales J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_1513495_3 1122197.ATWI01000013_gene2368 6.13e-32 114.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,467RN@72275|Alteromonadaceae 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_302730_1 330214.NIDE0835 1.85e-120 362.0 COG0074@1|root,COG0372@1|root,COG0074@2|Bacteria,COG0372@2|Bacteria 2|Bacteria C Belongs to the citrate synthase family - - 2.3.3.8,6.2.1.5 ko:K01902,ko:K15230,ko:K15233 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00352,R00405,R01322,R02404 RC00004,RC00014,RC00067 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0306 Citrate_synt,CoA_binding,Ligase_CoA,Succ_CoA_lig k59_612237_1 67352.JODS01000002_gene1307 0.000136 44.3 COG1473@1|root,COG1473@2|Bacteria,2GNEG@201174|Actinobacteria 201174|Actinobacteria S Peptidase, M20 - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_612237_2 1121861.KB899910_gene890 2.91e-58 205.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2U1DI@28211|Alphaproteobacteria,2JPI7@204441|Rhodospirillales 204441|Rhodospirillales G Major facilitator superfamily - - - - - - - - - - - - MFS_2 k59_101424_1 395493.BegalDRAFT_3485 4.98e-45 163.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,45ZN8@72273|Thiotrichales 72273|Thiotrichales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_1394613_1 439235.Dalk_0585 1.21e-18 90.5 COG0577@1|root,COG1340@1|root,COG2234@1|root,COG0577@2|Bacteria,COG1340@2|Bacteria,COG2234@2|Bacteria,1MVYE@1224|Proteobacteria,42PKN@68525|delta/epsilon subdivisions,2WIWP@28221|Deltaproteobacteria,2MIQI@213118|Desulfobacterales 28221|Deltaproteobacteria V FtsX-like permease family - - - - - - - - - - - - FtsX,PA,Peptidase_M28 k59_1603567_1 1267533.KB906735_gene4552 1.69e-17 86.7 COG1641@1|root,COG1641@2|Bacteria,3Y42R@57723|Acidobacteria,2JI6G@204432|Acidobacteriia 204432|Acidobacteriia S Protein of unknown function DUF111 - - 4.99.1.12 ko:K09121 - - - - ko00000,ko01000 - - - DUF111 k59_1030751_2 1301098.PKB_4241 1.26e-117 343.0 COG1028@1|root,COG1028@2|Bacteria,1P1U4@1224|Proteobacteria,1RR3M@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_520223_1 333138.LQ50_23020 1.01e-07 51.2 COG0346@1|root,COG0346@2|Bacteria,1VH3Z@1239|Firmicutes,4HNY3@91061|Bacilli,1ZGZ5@1386|Bacillus 91061|Bacilli E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_520223_2 468556.AQYG01000048_gene751 2.97e-33 129.0 COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,4GBW2@85026|Gordoniaceae 201174|Actinobacteria E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_101438_1 1004785.AMBLS11_08165 1.91e-36 135.0 COG3386@1|root,COG3386@2|Bacteria,1MX7V@1224|Proteobacteria,1RMQK@1236|Gammaproteobacteria,469RD@72275|Alteromonadaceae 1236|Gammaproteobacteria G Strictosidine synthase - - - - - - - - - - - - SGL,Str_synth k59_101438_2 1484460.JSWG01000012_gene1459 0.000597 41.6 COG0457@1|root,COG0457@2|Bacteria,4NFIY@976|Bacteroidetes,1HYA6@117743|Flavobacteriia 976|Bacteroidetes S PFAM Peptidase family M49 - - - - - - - - - - - - Peptidase_M49 k59_1603574_2 2074.JNYD01000005_gene3066 0.000122 47.8 COG2207@1|root,COG2207@2|Bacteria,2IRN1@201174|Actinobacteria,4E8E5@85010|Pseudonocardiales 201174|Actinobacteria K AraC-binding-like domain - - - - - - - - - - - - AraC_binding_2,HTH_18 k59_719815_1 1150469.RSPPHO_01840 5.5e-19 87.8 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRII@28211|Alphaproteobacteria,2JQB3@204441|Rhodospirillales 204441|Rhodospirillales I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_719815_2 1132442.KB889752_gene909 4.57e-09 57.0 COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,4H9X5@91061|Bacilli,1ZS2F@1386|Bacillus 91061|Bacilli E O-acetylhomoserine metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_1603581_1 269796.Rru_A0230 6.49e-15 81.6 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JQXF@204441|Rhodospirillales 204441|Rhodospirillales E COG0367 Asparagine synthase (glutamine-hydrolyzing) - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1513571_1 227377.CBU_0716 3.28e-08 59.7 COG0492@1|root,COG0492@2|Bacteria,1MVWS@1224|Proteobacteria,1RRRH@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Thioredoxin reductase - - - - - - - - - - - - Pyr_redox_2 k59_1030796_1 1122197.ATWI01000009_gene1569 2.72e-116 341.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,46489@72275|Alteromonadaceae 1236|Gammaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b1091,iAPECO1_1312.APECO1_172,iBWG_1329.BWG_0939,iE2348C_1286.E2348C_1183,iEC55989_1330.EC55989_1203,iECABU_c1320.ECABU_c13040,iECDH10B_1368.ECDH10B_1163,iECDH1ME8569_1439.ECDH1ME8569_1026,iECED1_1282.ECED1_1234,iECH74115_1262.ECH74115_1470,iECIAI39_1322.ECIAI39_2070,iECO103_1326.ECO103_1136,iECO111_1330.ECO111_1368,iECO26_1355.ECO26_1424,iECOK1_1307.ECOK1_1198,iECP_1309.ECP_1083,iECS88_1305.ECS88_1105,iECSP_1301.ECSP_1392,iECW_1372.ECW_m1199,iECs_1301.ECs1469,iEKO11_1354.EKO11_2743,iETEC_1333.ETEC_1156,iEcDH1_1363.EcDH1_2556,iEcE24377_1341.EcE24377A_1212,iEcSMS35_1347.EcSMS35_2036,iG2583_1286.G2583_1351,iJO1366.b1091,iJR904.b1091,iLF82_1304.LF82_0609,iNRG857_1313.NRG857_05260,iSSON_1240.SSON_1111,iSbBS512_1146.SbBS512_E2233,iUMN146_1321.UM146_11870,iUMNK88_1353.UMNK88_1361,iUTI89_1310.UTI89_C1216,iWFL_1372.ECW_m1199,iY75_1357.Y75_RS05700,iZ_1308.Z1730,ic_1306.c1360 ACP_syn_III,ACP_syn_III_C k59_520280_1 65497.JODV01000003_gene4721 1.18e-17 77.8 COG1225@1|root,COG1225@2|Bacteria,2IFB1@201174|Actinobacteria,4E31I@85010|Pseudonocardiales 201174|Actinobacteria O Redoxin bcpB - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_520280_2 246196.MSMEI_3134 8.21e-09 54.7 COG1225@1|root,COG1225@2|Bacteria,2IFB1@201174|Actinobacteria,238QQ@1762|Mycobacteriaceae 201174|Actinobacteria O Peroxiredoxin bcpB - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_719843_1 1235457.C404_21145 5.84e-07 48.5 COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,2VVQK@28216|Betaproteobacteria,1K9CE@119060|Burkholderiaceae 28216|Betaproteobacteria KL Belongs to the transcriptional regulatory Fis family fis - - ko:K03557 ko05111,map05111 - - - ko00000,ko00001,ko03000,ko03036,ko03400 - - - HTH_8 k59_719843_2 483218.BACPEC_00303 1.25e-54 181.0 COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,249QD@186801|Clostridia,2691S@186813|unclassified Clostridiales 186801|Clostridia K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc - 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_719843_3 1158345.JNLL01000001_gene1083 1.6e-55 177.0 COG0347@1|root,COG0347@2|Bacteria,2G43N@200783|Aquificae 200783|Aquificae K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_1246143_1 1397666.RS24_01307 4.47e-38 145.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,4BPEA@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Electron transfer flavoprotein-ubiquinone oxidoreductase etf - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_405381_1 378806.STAUR_2949 2.22e-14 77.8 COG4206@1|root,COG4206@2|Bacteria,1R47X@1224|Proteobacteria,43BZA@68525|delta/epsilon subdivisions,2X7A1@28221|Deltaproteobacteria,2YU9I@29|Myxococcales 28221|Deltaproteobacteria M TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1030813_2 1096769.Pelub83DRAFT_0415 4.07e-36 122.0 2FDFA@1|root,345GY@2|Bacteria,1P1RR@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1612726_1 889378.Spiaf_2707 4.51e-11 64.7 COG0545@1|root,COG0652@1|root,COG0545@2|Bacteria,COG0652@2|Bacteria,2J58N@203691|Spirochaetes 203691|Spirochaetes O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB - 5.2.1.8 ko:K01802,ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - FKBP_C,Pro_isomerase k59_204539_1 1131266.ARWQ01000001_gene1257 8.92e-101 312.0 COG2511@1|root,arCOG01719@2157|Archaea,41S8Q@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate gatE - 6.3.5.7 ko:K03330 ko00970,ko01100,map00970,map01100 - R03905 RC00010 ko00000,ko00001,ko01000 - - - GAD,GatB_N,GatB_Yqey k59_626635_1 2340.JV46_13050 1.28e-38 137.0 COG1014@1|root,COG1144@1|root,COG1014@2|Bacteria,COG1144@2|Bacteria,1N12F@1224|Proteobacteria,1S7UK@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate - - 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR k59_626635_2 472759.Nhal_0357 3.13e-105 315.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales 1236|Gammaproteobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_990277_1 1122236.KB905141_gene1251 3.65e-09 57.4 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2VHDG@28216|Betaproteobacteria,2KM0C@206350|Nitrosomonadales 206350|Nitrosomonadales M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_990277_2 1123399.AQVE01000027_gene36 1.92e-82 258.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,45ZPT@72273|Thiotrichales 72273|Thiotrichales M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_990278_1 879212.DespoDRAFT_00367 4.03e-32 120.0 COG2165@1|root,COG2165@2|Bacteria,1QYWM@1224|Proteobacteria,43DBQ@68525|delta/epsilon subdivisions,2WVZ5@28221|Deltaproteobacteria,2MNW2@213118|Desulfobacterales 28221|Deltaproteobacteria NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl k59_990319_1 911045.PSE_0437 1.64e-88 276.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQQH@28211|Alphaproteobacteria 28211|Alphaproteobacteria E ABC-type dipeptide transport system periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_884901_1 1089550.ATTH01000001_gene2547 3.04e-56 194.0 COG1757@1|root,COG1757@2|Bacteria,4NHP9@976|Bacteroidetes,1FIXG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Na H antiporter - - - - - - - - - - - - Na_H_antiporter k59_1195957_1 436308.Nmar_0471 8.9e-105 325.0 COG1948@1|root,arCOG02284@2157|Archaea,41T0R@651137|Thaumarchaeota 651137|Thaumarchaeota L Beta propeller domain - - - - - - - - - - - - Beta_propel k59_23676_1 889378.Spiaf_1663 5.91e-171 496.0 COG0028@1|root,COG0028@2|Bacteria,2J5EZ@203691|Spirochaetes 203691|Spirochaetes H TIGRFAM acetolactate synthase, large subunit, biosynthetic type - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_23676_2 744872.Spica_2691 1.01e-44 151.0 COG0440@1|root,COG0440@2|Bacteria,2J7CQ@203691|Spirochaetes 203691|Spirochaetes E Acetolactate synthase, small subunit - - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_1407492_1 1380391.JIAS01000018_gene826 4.97e-103 319.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2JPA1@204441|Rhodospirillales 204441|Rhodospirillales P COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_730686_1 1242864.D187_006569 8.19e-14 70.1 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,42MAM@68525|delta/epsilon subdivisions,2WK4Y@28221|Deltaproteobacteria,2YV0E@29|Myxococcales 28221|Deltaproteobacteria D ABC transporter ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_730694_1 1207063.P24_03720 3.19e-176 503.0 COG2252@1|root,COG2252@2|Bacteria,1MUV0@1224|Proteobacteria,2TRC0@28211|Alphaproteobacteria,2JQGH@204441|Rhodospirillales 204441|Rhodospirillales S Permease family - - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - Xan_ur_permease k59_779609_1 330214.NIDE3948 2.71e-55 186.0 2CB8G@1|root,2Z88H@2|Bacteria 2|Bacteria S Putative beta-barrel porin-2, OmpL-like. bbp2 - - - - - - - - - - - - BBP2 k59_204715_1 247634.GPB2148_96 3.53e-66 224.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria,1SMN0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1559273_1 522306.CAP2UW1_3066 3.34e-222 639.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,1KPTQ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_571715_1 1198232.CYCME_0519 1.32e-62 196.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,1S21E@1236|Gammaproteobacteria,460F6@72273|Thiotrichales 72273|Thiotrichales H May be involved in the biosynthesis of molybdopterin - - 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_1612824_1 330214.NIDE1735 8.67e-52 177.0 COG0784@1|root,COG0784@2|Bacteria 2|Bacteria T Response regulator, receiver VP1245 - - - - - - - - - - - DUF3369,EAL,GAF_2,GGDEF,HATPase_c,HD,HisKA,Response_reg,cNMP_binding k59_990488_1 396595.TK90_0719 3.07e-115 350.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WWQ6@135613|Chromatiales 135613|Chromatiales CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_571742_1 1286106.MPL1_11663 1.2e-92 285.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,46021@72273|Thiotrichales 72273|Thiotrichales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_1612845_1 880071.Fleli_2887 5.95e-29 109.0 COG1403@1|root,COG1403@2|Bacteria,4NJ0T@976|Bacteroidetes,47MEF@768503|Cytophagia 976|Bacteroidetes L HNH endonuclease - - - - - - - - - - - - HNH,HNH_5 k59_23723_1 644282.Deba_0273 4.76e-48 171.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_885001_1 983545.Glaag_4153 7.37e-23 105.0 COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1QTVF@1224|Proteobacteria,1T40W@1236|Gammaproteobacteria,46D7U@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_204830_1 493475.GARC_2914 2.29e-12 67.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,4642M@72275|Alteromonadaceae 1236|Gammaproteobacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - ic_1306.c0216 Hexapep,Hexapep_2,LpxD k59_204830_2 425104.Ssed_3150 6.75e-62 194.0 COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,2QAP4@267890|Shewanellaceae 1236|Gammaproteobacteria I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019171,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - iJN746.PP_1602 FabA k59_204830_3 556268.OFAG_00202 2.51e-10 62.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2VHDG@28216|Betaproteobacteria,472GR@75682|Oxalobacteraceae 28216|Betaproteobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_1352376_1 667014.Thein_1044 7.47e-05 50.8 COG0860@1|root,COG0860@2|Bacteria,2GH8K@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria M Ami_3 - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,LysM k59_730824_1 1111728.ATYS01000007_gene1269 3.95e-31 113.0 COG0607@1|root,COG0607@2|Bacteria,1MZ87@1224|Proteobacteria,1S98V@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Rhodanese domain protein - - - - - - - - - - - - Rhodanese k59_571812_1 349124.Hhal_1263 1.1e-49 161.0 COG2954@1|root,COG2954@2|Bacteria,1RI38@1224|Proteobacteria,1S77V@1236|Gammaproteobacteria,1WYAI@135613|Chromatiales 135613|Chromatiales S PFAM Adenylate cyclase - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CYTH k59_1352414_1 240015.ACP_0337 3.33e-49 174.0 COG3046@1|root,COG3046@2|Bacteria,3Y47V@57723|Acidobacteria,2JJ03@204432|Acidobacteriia 204432|Acidobacteriia S Deoxyribodipyrimidine photo-lyase-related protein - - - ko:K06876 - - - - ko00000 - - - DPRP,FAD_binding_7 k59_23751_1 383372.Rcas_4265 8.36e-16 77.0 COG0536@1|root,COG0536@2|Bacteria,2G5ZT@200795|Chloroflexi,3752E@32061|Chloroflexia 32061|Chloroflexia S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - DUF1967,GTP1_OBG,MMR_HSR1 k59_23751_2 243090.RB6770 3.9e-29 106.0 COG0211@1|root,COG0211@2|Bacteria,2J04T@203682|Planctomycetes 203682|Planctomycetes J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_23751_3 309807.SRU_1420 9.69e-05 44.3 COG0261@1|root,COG0261@2|Bacteria,4NSHE@976|Bacteroidetes,1FJG0@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - HHH_5,Rho_N,Ribosomal_L21p k59_779760_1 981085.XP_010110724.1 2.9e-27 109.0 COG1132@1|root,KOG0055@2759|Eukaryota,37J30@33090|Viridiplantae,3GB0T@35493|Streptophyta,4JF51@91835|fabids 35493|Streptophyta Q ABC transporter I family member - GO:0003674,GO:0005215,GO:0005338,GO:0005460,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0010035,GO:0010038,GO:0010044,GO:0012506,GO:0015075,GO:0015165,GO:0015711,GO:0015780,GO:0015786,GO:0015931,GO:0015932,GO:0016020,GO:0022857,GO:0031090,GO:0031982,GO:0034220,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090481,GO:0098588,GO:0098656,GO:0098805,GO:1901264,GO:1901505 - - - - - - - - - - ABC_tran k59_885064_1 76114.ebA3379 5.41e-73 230.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,2KUCQ@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_990670_1 517418.Ctha_0317 1.85e-39 150.0 COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria 2|Bacteria - - - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC_transp_aux k59_1407730_1 1380387.JADM01000002_gene2070 1.76e-85 277.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XHBW@135619|Oceanospirillales 135619|Oceanospirillales P P-type ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_1196249_1 1200567.JNKD01000001_gene1724 8.25e-11 67.8 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,1Y3NF@135624|Aeromonadales 135624|Aeromonadales G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB - - ko:K19804 - - - - ko00000 - - - TPR_16,TPR_19,TPR_7 k59_1041411_1 1144310.PMI07_001133 1.07e-37 139.0 COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,4BG3R@82115|Rhizobiaceae 28211|Alphaproteobacteria S Amidohydrolase - - 4.1.1.45 ko:K03392 ko00380,ko01100,map00380,map01100 M00038 R04323 RC00779 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_2 k59_730870_1 1177179.A11A3_05184 5.43e-12 66.2 COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,1RN24@1236|Gammaproteobacteria,1XIVH@135619|Oceanospirillales 135619|Oceanospirillales S FAD dependent oxidoreductase - - - ko:K15736 - - - - ko00000,ko01000 - - - DAO k59_1612916_1 1417296.U879_17700 1.14e-19 82.0 COG3369@1|root,COG3369@2|Bacteria,1N6QZ@1224|Proteobacteria,2UGR1@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Iron-binding zinc finger CDGSH type - - - - - - - - - - - - zf-CDGSH k59_1407745_1 622637.KE124774_gene3542 4.72e-74 236.0 COG3385@1|root,COG3385@2|Bacteria,1QURV@1224|Proteobacteria,2TW56@28211|Alphaproteobacteria,371IT@31993|Methylocystaceae 28211|Alphaproteobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_779779_1 765912.Thimo_0237 2.33e-78 250.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1WWTF@135613|Chromatiales 135613|Chromatiales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane - - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_1196271_1 331869.BAL199_24989 2.79e-15 73.2 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,4BPA2@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E ABC transporter glnQ - 3.6.3.21 ko:K02028,ko:K09972 ko02010,map02010 M00232,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - ABC_tran k59_1041431_1 999141.GME_02550 8.95e-19 80.5 COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria,1XIY0@135619|Oceanospirillales 135619|Oceanospirillales L Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH - - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX k59_1041431_2 187272.Mlg_0426 2.42e-47 159.0 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1WXJF@135613|Chromatiales 135613|Chromatiales E HAD-superfamily subfamily IB hydrolase, TIGR01490 - - - - - - - - - - - - HAD k59_730894_1 1894.JOER01000074_gene7581 6.58e-59 203.0 COG0147@1|root,COG0512@1|root,COG0147@2|Bacteria,COG0512@2|Bacteria,2GKJT@201174|Actinobacteria 201174|Actinobacteria EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia pabB - 2.6.1.85,4.1.3.27,4.1.3.38 ko:K01657,ko:K01665,ko:K03342,ko:K13950 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716,R05553 RC00010,RC01418,RC01843,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4,Anth_synt_I_N,Chorismate_bind,GATase k59_1409829_1 290512.Paes_0751 3.72e-37 133.0 COG2885@1|root,COG2885@2|Bacteria,1FEC5@1090|Chlorobi 1090|Chlorobi M PFAM OmpA MotB domain protein - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_1043391_2 1177181.T9A_00092 2.61e-13 69.7 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,1XHKR@135619|Oceanospirillales 135619|Oceanospirillales D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_886958_1 709797.CSIRO_0736 1.81e-31 119.0 COG2070@1|root,COG2070@2|Bacteria,1MU0U@1224|Proteobacteria,2TS5U@28211|Alphaproteobacteria,3JUQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Nitronate monooxygenase MA20_20575 - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_886958_2 568816.Acin_1210 1.34e-09 58.2 COG2050@1|root,COG2050@2|Bacteria,1V824@1239|Firmicutes,4H5IG@909932|Negativicutes 909932|Negativicutes Q Thioesterase family - - - - - - - - - - - - 4HBT k59_208219_1 483219.LILAB_15790 2.2e-60 201.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,42U5W@68525|delta/epsilon subdivisions,2WQUQ@28221|Deltaproteobacteria,2YX8E@29|Myxococcales 28221|Deltaproteobacteria L Transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,Nterm_IS4 k59_781756_2 392499.Swit_5197 6.5e-25 102.0 COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2TUGE@28211|Alphaproteobacteria,2K3NU@204457|Sphingomonadales 204457|Sphingomonadales L Protein involved in DNA binding and transposition, DNA-mediated - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_1354450_1 990073.ATHU01000001_gene1116 4.65e-07 52.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,42SJJ@68525|delta/epsilon subdivisions,2YPEW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_260885_1 768671.ThimaDRAFT_3794 4.7e-43 151.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria,1WWNS@135613|Chromatiales 135613|Chromatiales I TIGRFAM malonyl CoA-acyl carrier protein transacylase - - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_1155976_1 1232410.KI421425_gene1551 7.23e-18 83.2 2B4XH@1|root,32REP@2|Bacteria,1PXEZ@1224|Proteobacteria,4305C@68525|delta/epsilon subdivisions,2WVH5@28221|Deltaproteobacteria,43UUP@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_738052_1 338969.Rfer_2608 8.65e-27 111.0 COG2199@1|root,COG3706@2|Bacteria,1MVME@1224|Proteobacteria,2WEF3@28216|Betaproteobacteria,4ADFW@80864|Comamonadaceae 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_476828_1 1123489.AUAN01000005_gene1657 1.16e-61 200.0 COG1703@1|root,COG1703@2|Bacteria,1TQT4@1239|Firmicutes,4H1WI@909932|Negativicutes 909932|Negativicutes E LAO AO transport system argK - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k59_476833_1 1089439.KB902270_gene2694 4.21e-07 57.4 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,45ZQ0@72273|Thiotrichales 72273|Thiotrichales M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_635475_1 436308.Nmar_0831 4.95e-113 332.0 COG0057@1|root,arCOG00493@2157|Archaea,41SDF@651137|Thaumarchaeota 651137|Thaumarchaeota G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family - - 1.2.1.59 ko:K00150 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166 R01061,R01063 RC00149 ko00000,ko00001,ko00002,ko01000 - - - - k59_792069_1 1123257.AUFV01000013_gene2879 1.41e-109 338.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,1X4FN@135614|Xanthomonadales 135614|Xanthomonadales G Glucose dehydrogenase gcd2 - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 k59_1210170_1 420662.Mpe_B0541 8.04e-124 371.0 COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,2VIT2@28216|Betaproteobacteria,1KK96@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Methylmalonyl-CoA mutase icmF - 5.4.99.2,5.4.99.63,5.4.99.64 ko:K01847,ko:K01848,ko:K14447,ko:K20906 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833,R09292 RC00395,RC02835 ko00000,ko00001,ko00002,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_320924_1 330214.NIDE3799 7.74e-105 306.0 COG2249@1|root,COG2249@2|Bacteria 2|Bacteria K NAD(P)H dehydrogenase (quinone) activity - - - - - - - - - - - - Flavodoxin_2 k59_1155992_1 673862.BABL1_437 2.05e-37 142.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_687563_2 402626.Rpic_1710 2.92e-52 174.0 COG0462@1|root,COG0462@2|Bacteria,1MUV7@1224|Proteobacteria,2VJI6@28216|Betaproteobacteria,1K6IC@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the ribose-phosphate pyrophosphokinase family - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran,Pribosyltran_N k59_1051828_1 870187.Thini_3392 3.11e-61 206.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,45ZR1@72273|Thiotrichales 72273|Thiotrichales M acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1104110_1 748247.AZKH_p0367 0.000199 45.1 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VH5N@28216|Betaproteobacteria 28216|Betaproteobacteria Q ABC-type transport system involved in resistance to organic solvents, permease component - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE,STAS_2 k59_1104110_2 187272.Mlg_0685 8.6e-40 141.0 COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,1WW5X@135613|Chromatiales 135613|Chromatiales J Elongation factor P--(R)-beta-lysine ligase - - - ko:K04568 - - - - ko00000,ko01000,ko03012 - - - tRNA-synt_2 k59_738069_1 156889.Mmc1_1102 1.49e-64 204.0 COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria,1R71B@1224|Proteobacteria,2TVMK@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_20,HTH_5,Rhodanese k59_1262278_1 926561.KB900617_gene1758 5.01e-13 68.2 COG0752@1|root,COG0752@2|Bacteria,1TPW8@1239|Firmicutes,24AU0@186801|Clostridia,3WAA3@53433|Halanaerobiales 186801|Clostridia J PFAM glycyl-tRNA synthetase alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_1262278_2 429009.Adeg_1733 1.76e-44 163.0 COG0751@1|root,COG0751@2|Bacteria,1TNZ7@1239|Firmicutes,248RS@186801|Clostridia,42FPG@68295|Thermoanaerobacterales 186801|Clostridia J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_476847_1 1353529.M899_3445 9.8e-25 112.0 2EJ8D@1|root,33CZJ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1470390_1 1333998.M2A_2780 2.32e-157 458.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Flavoprotein involved in K transport - - 1.14.13.160,1.14.13.22,1.14.13.226 ko:K03379,ko:K18371,ko:K21730 ko00640,ko00930,ko01120,ko01220,map00640,map00930,map01120,map01220 - R02231,R06622,R10704 RC00662,RC01550,RC03250 ko00000,ko00001,ko01000 - - - FMO-like,Pyr_redox_2,Pyr_redox_3 k59_687578_1 268747.Q58LA1_BPPRS 8.14e-30 113.0 4QCHF@10239|Viruses,4QW57@35237|dsDNA viruses no RNA stage,4QPIH@28883|Caudovirales,4QHVS@10662|Myoviridae 10662|Myoviridae S PhoH-like protein - - - - - - - - - - - - - k59_687578_2 869662.M4PRG2_9CAUD 2.04e-74 231.0 4QGKA@10239|Viruses,4QZ0K@35237|dsDNA viruses no RNA stage,4QQEP@28883|Caudovirales,4QJX7@10662|Myoviridae 10662|Myoviridae S PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - - k59_687578_3 268746.Q58N03_BPPRM 2.18e-23 92.0 4QHYU@10662|Myoviridae 10662|Myoviridae S Pfam:Trans_coact - - - - - - - - - - - - - k59_1262287_1 243231.GSU1927 1.41e-13 76.6 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,43UE7@69541|Desulfuromonadales 28221|Deltaproteobacteria T Response regulator receiver modulated diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - - - - - - - - - - EAL,GGDEF,PAS_3,Response_reg k59_110797_1 1242864.D187_010083 4.47e-44 159.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2YUEK@29|Myxococcales 28221|Deltaproteobacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_895211_1 991905.SL003B_1380 6.53e-20 92.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,4BP7N@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_895211_2 706587.Desti_3752 9.36e-49 171.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,42N2V@68525|delta/epsilon subdivisions,2WIPS@28221|Deltaproteobacteria,2MRVG@213462|Syntrophobacterales 28221|Deltaproteobacteria O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_1104123_1 443598.AUFA01000013_gene6509 7.8e-130 392.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,3JSA9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EQ Hydantoinase/oxoprolinase MA20_04185 - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_946566_1 1501391.LG35_08335 3.49e-37 138.0 COG4221@1|root,COG4221@2|Bacteria,4PKGY@976|Bacteroidetes,2FSDE@200643|Bacteroidia,22U7X@171550|Rikenellaceae 976|Bacteroidetes S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_161544_1 686340.Metal_0944 2.39e-94 289.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1XESK@135618|Methylococcales 135618|Methylococcales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_110799_1 1288826.MSNKSG1_04226 2.44e-27 100.0 COG1551@1|root,COG1551@2|Bacteria,1N6PG@1224|Proteobacteria,1SCB4@1236|Gammaproteobacteria,468BS@72275|Alteromonadaceae 1236|Gammaproteobacteria T Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005979,GO:0006109,GO:0006139,GO:0006417,GO:0006446,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0010675,GO:0010677,GO:0010906,GO:0010962,GO:0016070,GO:0016071,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032881,GO:0032885,GO:0034248,GO:0034249,GO:0034641,GO:0043170,GO:0043255,GO:0043467,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045719,GO:0045912,GO:0045947,GO:0046483,GO:0048027,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0062012,GO:0065007,GO:0070873,GO:0070874,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:2000112,GO:2000113 - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k59_110799_2 1400520.LFAB_10305 3.7e-16 79.7 COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,4H9XC@91061|Bacilli,3F3QS@33958|Lactobacillaceae 91061|Bacilli J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_1470404_1 360911.EAT1b_1611 1.1e-47 162.0 COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,4H9S9@91061|Bacilli,3WEIK@539002|Bacillales incertae sedis 91061|Bacilli E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_687585_1 1122962.AULH01000001_gene1376 3.13e-20 95.1 COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2TSQ2@28211|Alphaproteobacteria,36YGE@31993|Methylocystaceae 28211|Alphaproteobacteria P NnrS protein nnrS - - ko:K07234 - - - - ko00000 - - - NnrS k59_738084_1 472759.Nhal_2825 1.74e-58 197.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1WX2I@135613|Chromatiales 135613|Chromatiales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_842793_2 436308.Nmar_0640 1.75e-66 205.0 arCOG08653@1|root,arCOG08653@2157|Archaea,41T9H@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1417232_1 998674.ATTE01000001_gene2545 2.15e-25 101.0 COG0526@1|root,COG0526@2|Bacteria 2|Bacteria CO cell redox homeostasis - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - AhpC-TSA,Thioredoxin k59_1573478_1 1131266.ARWQ01000009_gene922 3.25e-55 192.0 COG0640@1|root,COG1328@1|root,arCOG00734@2157|Archaea,arCOG04889@2157|Archaea,41SBG@651137|Thaumarchaeota 651137|Thaumarchaeota FK Anaerobic ribonucleoside-triphosphate reductase - - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - ATP-cone,HTH_20,NRDD k59_1156021_1 497964.CfE428DRAFT_3353 1.05e-48 168.0 COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,46SGF@74201|Verrucomicrobia 74201|Verrucomicrobia H UBA THIF-type NAD FAD binding protein thiF - 2.7.7.80,2.8.1.11 ko:K21147 ko04122,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - Rhodanese,ThiF k59_3535_1 596330.HMPREF0628_1436 2.74e-17 82.0 COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,22GKU@1570339|Peptoniphilaceae 186801|Clostridia O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_3535_2 880072.Desac_2364 0.000413 42.7 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,42QAC@68525|delta/epsilon subdivisions,2WN8H@28221|Deltaproteobacteria,2MQIS@213462|Syntrophobacterales 28221|Deltaproteobacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_424901_1 1469607.KK073768_gene3285 2.49e-50 181.0 COG1020@1|root,COG1020@2|Bacteria,1GBN8@1117|Cyanobacteria 1117|Cyanobacteria Q PFAM Phosphopantetheine attachment site - - - - - - - - - - - - ADH_zinc_N,AMP-binding,AMP-binding_C,Condensation,KR,Nitroreductase,PP-binding k59_738092_1 641491.DND132_1978 2.59e-13 68.9 COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,42TBH@68525|delta/epsilon subdivisions,2WPJ5@28221|Deltaproteobacteria,2MCZ0@213115|Desulfovibrionales 28221|Deltaproteobacteria Q DSBA oxidoreductase - - - - - - - - - - - - DSBA k59_1052553_1 713586.KB900536_gene135 1.22e-86 268.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1WX71@135613|Chromatiales 135613|Chromatiales I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_529825_1 573413.Spirs_3325 6.46e-09 64.7 COG2834@1|root,COG2834@2|Bacteria,2J5AT@203691|Spirochaetes 203691|Spirochaetes M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_1417981_1 595494.Tola_2697 1.23e-66 226.0 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1Y3F1@135624|Aeromonadales 135624|Aeromonadales G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_529828_1 1123401.JHYQ01000012_gene2902 1e-34 135.0 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RPVU@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase creC GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031667,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 ko:K07641,ko:K07711 ko02020,ko02024,map02020,map02024 M00449,M00502 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,dCache_3,sCache_3_2 k59_738800_1 522772.Dacet_2821 3.72e-89 271.0 COG1484@1|root,COG1484@2|Bacteria,2GFU3@200930|Deferribacteres 2|Bacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 k59_793270_2 987059.RBXJA2T_13439 6.78e-16 73.6 COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,2VUY1@28216|Betaproteobacteria,1KMF8@119065|unclassified Burkholderiales 28216|Betaproteobacteria S PFAM Membrane protein of - - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 k59_688569_1 713586.KB900536_gene1257 7.52e-77 238.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1WWPW@135613|Chromatiales 135613|Chromatiales E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_62066_1 765914.ThisiDRAFT_1574 1.36e-37 128.0 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,1S8RT@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_62066_2 1121935.AQXX01000130_gene2503 1.25e-05 47.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1XIPR@135619|Oceanospirillales 135619|Oceanospirillales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_269003_1 400668.Mmwyl1_1308 1.13e-70 223.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,1XHDS@135619|Oceanospirillales 135619|Oceanospirillales K RNA polymerase sigma factor RpoS rpoS - - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_111483_1 1385514.N782_09260 1.76e-74 234.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1TQX3@1239|Firmicutes,4HCI6@91061|Bacilli,2Y90R@289201|Pontibacillus 91061|Bacilli S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_111483_2 999411.HMPREF1092_01546 6.67e-50 172.0 COG4294@1|root,COG4294@2|Bacteria,1TTCB@1239|Firmicutes,24BHY@186801|Clostridia,36FIA@31979|Clostridiaceae 186801|Clostridia L UV damage endonuclease UvdE uvdE - - ko:K13281 - - - - ko00000,ko01000 - - - DUF1722,UvdE k59_1052569_1 1380394.JADL01000002_gene1095 2.92e-54 180.0 COG1052@1|root,COG1052@2|Bacteria,1QVZS@1224|Proteobacteria,2TUUQ@28211|Alphaproteobacteria,2JRNF@204441|Rhodospirillales 204441|Rhodospirillales CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C k59_1052569_2 195105.CN97_17885 1.4e-17 80.9 COG1011@1|root,COG1011@2|Bacteria,1MU1H@1224|Proteobacteria,2TQVC@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Haloacid dehalogenase - - 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase k59_425640_1 697282.Mettu_0847 3.19e-30 114.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1XE1W@135618|Methylococcales 135618|Methylococcales E Belongs to the cysteine synthase cystathionine beta- synthase family - - 2.5.1.47 ko:K12339 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03132,R03601,R04859 RC00020,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_425640_2 301.JNHE01000034_gene4192 2.64e-45 152.0 COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,1YFT7@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 rimI GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_425640_3 748658.KB907312_gene1248 4.02e-08 53.9 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,1S2U7@1236|Gammaproteobacteria,1WWN0@135613|Chromatiales 135613|Chromatiales L TIGRFAM Phage SPO1 DNA polymerase-related protein - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_321736_1 1333998.M2A_0747 7.46e-68 230.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,4BPGQ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_688580_1 330214.NIDE4397 5.35e-114 338.0 COG0124@1|root,COG0124@2|Bacteria,3J0EC@40117|Nitrospirae 40117|Nitrospirae J Histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_1471444_1 648996.Theam_1517 2.12e-42 152.0 COG0182@1|root,COG0182@2|Bacteria,2G3UF@200783|Aquificae 200783|Aquificae J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B k59_1520015_1 691883.XP_009497588.1 2.37e-08 62.8 28HX2@1|root,2SCUW@2759|Eukaryota 2759|Eukaryota O Pregnancy-associated plasma protein-A PAPPA2 - - ko:K08647 - - - - ko00000,ko01000,ko01002 - - - Laminin_G_3,Notch,Peptidase_M43,Sushi k59_1052581_1 399739.Pmen_0257 5.67e-05 46.2 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1YEYS@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria O Magnesium chelatase, subunit ChlI C-terminal comM GO:0003674,GO:0003824,GO:0004176,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0042623,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_216623_1 243231.GSU2224 2.22e-12 68.2 COG0745@1|root,COG0745@2|Bacteria,1N9YT@1224|Proteobacteria,42W15@68525|delta/epsilon subdivisions,2WS2V@28221|Deltaproteobacteria,43T56@69541|Desulfuromonadales 28221|Deltaproteobacteria T regulator, PATAN and FRGAF domain-containing - - - - - - - - - - - - DUF4388,Response_reg k59_1104919_1 1191460.F959_01513 7.43e-25 104.0 COG1680@1|root,COG1680@2|Bacteria,1R5MK@1224|Proteobacteria,1S015@1236|Gammaproteobacteria,3NIR0@468|Moraxellaceae 1236|Gammaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1627024_1 330214.NIDE0488 3.74e-82 254.0 COG0019@1|root,COG0019@2|Bacteria,3J0CR@40117|Nitrospirae 40117|Nitrospirae E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_111501_1 1005999.GLGR_3446 4.95e-39 143.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria 1236|Gammaproteobacteria F bifunctional purine biosynthesis protein purh purH GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - iEcHS_1320.EcHS_A4240,iPC815.YPO3728 AICARFT_IMPCHas,MGS k59_111501_2 1196095.GAPWK_1901 8.77e-24 93.6 COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,1SD35@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters fis GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K03557 ko05111,map05111 - - - ko00000,ko00001,ko03000,ko03036,ko03400 - - - HTH_8 k59_1574215_1 338963.Pcar_1241 2.72e-78 250.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,43S9K@69541|Desulfuromonadales 28221|Deltaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_328981_1 765910.MARPU_15110 1.72e-65 214.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales 135613|Chromatiales J Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_536998_1 272631.ML1089 3.76e-72 229.0 COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,233NH@1762|Mycobacteriaceae 201174|Actinobacteria P Belongs to the ABC transporter superfamily sugC GO:0006810,GO:0008150,GO:0008643,GO:0009405,GO:0015766,GO:0015771,GO:0015772,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051179,GO:0051234,GO:0051704,GO:0071702 - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran k59_803232_1 1347392.CCEZ01000009_gene2325 1.72e-57 193.0 COG1619@1|root,COG1619@2|Bacteria,1TRBB@1239|Firmicutes,24ABA@186801|Clostridia,36EBC@31979|Clostridiaceae 186801|Clostridia V PFAM peptidase U61, LD-carboxypeptidase A - - 3.4.17.13 ko:K01297 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S66 k59_803232_2 1123274.KB899416_gene2660 3.23e-07 54.7 COG1680@1|root,COG1680@2|Bacteria,2J5Y0@203691|Spirochaetes 203691|Spirochaetes V beta-lactamase bla - 3.4.16.4 ko:K21469 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Beta-lactamase,DUF1343 k59_6983_1 395493.BegalDRAFT_2628 4.64e-78 235.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,460JG@72273|Thiotrichales 72273|Thiotrichales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_381869_1 1267535.KB906767_gene4804 4.72e-45 152.0 COG0406@1|root,COG0406@2|Bacteria,3Y4QW@57723|Acidobacteria,2JJB8@204432|Acidobacteriia 204432|Acidobacteriia G Phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 k59_381869_2 323261.Noc_2716 8.64e-14 72.0 COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,1RMKB@1236|Gammaproteobacteria,1WWEE@135613|Chromatiales 135613|Chromatiales H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_276354_1 574966.KB898653_gene1332 8.1e-30 119.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,1XI65@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA,PAS,PAS_8 k59_276354_2 1122603.ATVI01000007_gene1582 1.11e-37 132.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,1X316@135614|Xanthomonadales 135614|Xanthomonadales KT Two component response regulator for the phosphate regulon phoB - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1427267_1 1089551.KE386572_gene1634 6.61e-66 217.0 COG5598@1|root,COG5598@2|Bacteria,1N18H@1224|Proteobacteria,2TRUE@28211|Alphaproteobacteria,4BRNZ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria H Trimethylamine methyltransferase (MTTB) mttB2 - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB k59_1480914_1 1229909.NSED_02485 2.82e-164 471.0 COG0719@1|root,arCOG01715@2157|Archaea,41S7W@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly protein SufD - - - ko:K09014,ko:K09015 - - - - ko00000 - - - UPF0051 k59_1524854_1 1379270.AUXF01000001_gene2024 0.000479 48.5 COG4447@1|root,COG4447@2|Bacteria,1ZT1T@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 k59_1427268_1 1049564.TevJSym_ao00680 1.01e-40 146.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1J4UD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S11 family dacA GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - iEC55989_1330.EC55989_2269,iSFV_1184.SFV_0694,iSbBS512_1146.SbBS512_E2506,iYL1228.KPN_00664 PBP5_C,Peptidase_S11 k59_1427268_2 396588.Tgr7_2706 2.3e-73 229.0 COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1WX40@135613|Chromatiales 135613|Chromatiales EH PFAM Aminotransferase, class IV - - 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 k59_1272947_1 450851.PHZ_c0339 4.09e-54 192.0 COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,2KFHW@204458|Caulobacterales 204458|Caulobacterales C Oxidizes proline to glutamate for use as a carbon and nitrogen source - - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_381881_1 436308.Nmar_1709 2.78e-77 246.0 COG0661@1|root,arCOG01189@2157|Archaea,41SYQ@651137|Thaumarchaeota 651137|Thaumarchaeota S ABC1 family - - - - - - - - - - - - ABC1 k59_537003_1 1163617.SCD_n01945 3.98e-136 406.0 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2VJUR@28216|Betaproteobacteria 28216|Betaproteobacteria S AAA domain - - - ko:K07028 - - - - ko00000 - - - AAA_33,APH k59_537003_3 748658.KB907321_gene824 1.24e-57 192.0 COG1812@1|root,COG1812@2|Bacteria,1QPB9@1224|Proteobacteria 1224|Proteobacteria E S-Adenosylmethionine synthetase metK-2 - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_Synthase k59_746001_1 138119.DSY4885 2.94e-05 51.2 COG1922@1|root,COG1922@2|Bacteria,1V3QV@1239|Firmicutes,24AQ3@186801|Clostridia,261IN@186807|Peptococcaceae 186801|Clostridia M Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid - - 2.4.1.187 ko:K05946 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01003 - GT26 - Glyco_tran_WecB k59_954728_1 1232410.KI421413_gene781 2.84e-72 238.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42MBP@68525|delta/epsilon subdivisions,2WJAJ@28221|Deltaproteobacteria,43TZD@69541|Desulfuromonadales 28221|Deltaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family lpdA-4 - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_1480926_1 1158292.JPOE01000002_gene1873 6.91e-72 230.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2VH9K@28216|Betaproteobacteria,1KJCP@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_1480926_2 401053.AciPR4_2722 0.000482 42.0 COG1136@1|root,COG1136@2|Bacteria,3Y2QD@57723|Acidobacteria,2JJ3C@204432|Acidobacteriia 204432|Acidobacteriia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_71503_1 595536.ADVE02000001_gene551 3.76e-71 229.0 COG3385@1|root,COG3385@2|Bacteria,1R821@1224|Proteobacteria,2VG9M@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_1427294_1 1509403.GW12_00670 1.93e-07 49.7 2BTV0@1|root,32P2Q@2|Bacteria,1Q8QF@1224|Proteobacteria,1RTBA@1236|Gammaproteobacteria,3NSHE@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_488001_1 1121090.KB894700_gene3293 3.32e-34 132.0 COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,4HAU0@91061|Bacilli,1ZBRF@1386|Bacillus 91061|Bacilli H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_7194_1 472759.Nhal_0545 1.46e-155 452.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1WW9V@135613|Chromatiales 135613|Chromatiales J TIGRFAM ribonuclease, Rne Rng family - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1481581_1 330214.NIDE4166 4.78e-77 233.0 COG2210@1|root,COG2210@2|Bacteria 2|Bacteria P Belongs to the sulfur carrier protein TusA family cdr - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA k59_1481581_2 330214.NIDE4165 2.02e-44 144.0 COG0425@1|root,COG0425@2|Bacteria,3J1C1@40117|Nitrospirae 40117|Nitrospirae O Sulfurtransferase TusA - - - - - - - - - - - - TusA k59_120374_1 1033802.SSPSH_001227 8.48e-88 275.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,1RPM0@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - iSF_1195.SF3422,iUTI89_1310.UTI89_C3903 PEPCK_ATP k59_72179_1 390989.JOEG01000001_gene5319 3.55e-28 107.0 COG0454@1|root,COG0456@2|Bacteria,2II3I@201174|Actinobacteria,4DMRS@85008|Micromonosporales 201174|Actinobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_851283_1 396588.Tgr7_1236 8.17e-20 88.6 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1WWX2@135613|Chromatiales 135613|Chromatiales J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB - 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS k59_851283_2 1049564.TevJSym_ac00140 2.12e-08 58.2 COG1999@1|root,COG4531@1|root,COG1999@2|Bacteria,COG4531@2|Bacteria,1RHJ8@1224|Proteobacteria,1SYEA@1236|Gammaproteobacteria,1J6I1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC,ZnuA k59_120380_1 96561.Dole_0481 8.98e-25 103.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,42NJ0@68525|delta/epsilon subdivisions,2WJ7A@28221|Deltaproteobacteria,2MIEV@213118|Desulfobacterales 28221|Deltaproteobacteria M SMART PDZ DHR GLGF domain protein rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_1007593_1 1131266.ARWQ01000006_gene260 1.04e-43 151.0 COG2084@1|root,arCOG00247@2157|Archaea,41SI2@651137|Thaumarchaeota 651137|Thaumarchaeota I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1007593_2 436308.Nmar_0634 1.88e-12 65.9 COG1028@1|root,arCOG01259@2157|Archaea,41SXY@651137|Thaumarchaeota 651137|Thaumarchaeota I Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_646866_1 667014.Thein_1696 9.7e-114 339.0 COG0014@1|root,COG0014@2|Bacteria,2GH1U@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1319708_1 1297742.A176_04195 3.31e-45 162.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,42NMY@68525|delta/epsilon subdivisions,2WJ8S@28221|Deltaproteobacteria,2YU74@29|Myxococcales 28221|Deltaproteobacteria M Mur ligase family, catalytic domain mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1582089_1 1229909.NSED_02775 9.58e-109 325.0 COG0128@1|root,arCOG04134@2157|Archaea,41S5I@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_170143_1 314230.DSM3645_06149 3.15e-41 143.0 COG1595@1|root,COG1595@2|Bacteria,2J0GI@203682|Planctomycetes 203682|Planctomycetes K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_170143_2 522306.CAP2UW1_4244 1.1e-29 110.0 COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,2VWVP@28216|Betaproteobacteria,1KR3H@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C ArsC family arsC - 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC,Glutaredoxin k59_170143_3 1267535.KB906767_gene3861 4.98e-42 146.0 COG4103@1|root,COG4103@2|Bacteria 2|Bacteria T Tellurite resistance protein TerB - - - - - - - - - - - - TerB k59_1273676_1 338963.Pcar_1212 2.68e-63 209.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,42P1P@68525|delta/epsilon subdivisions,2WJ99@28221|Deltaproteobacteria,43VZN@69541|Desulfuromonadales 28221|Deltaproteobacteria S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48,TAT_signal,TPR_16,TPR_19 k59_276983_1 644076.SCH4B_0570 3.02e-10 62.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,4NAG1@97050|Ruegeria 28211|Alphaproteobacteria Q Trap c4-dicarboxylate transport system permease dctm subunit - - - - - - - - - - - - DctM k59_276983_2 1238182.C882_3990 2.14e-56 182.0 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2U75U@28211|Alphaproteobacteria,2JT3D@204441|Rhodospirillales 204441|Rhodospirillales Q COG4665 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - - - - - - - - - - DctQ k59_1163222_1 1168065.DOK_13047 0.000598 44.7 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the GPAT DAPAT family - - - - - - - - - - - - Acyltransferase k59_1163222_2 1499683.CCFF01000014_gene4058 5.28e-34 134.0 COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,36DFC@31979|Clostridiaceae 186801|Clostridia S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_1112682_1 1229909.NSED_03220 3.19e-75 230.0 COG1920@1|root,arCOG04472@2157|Archaea,41SPV@651137|Thaumarchaeota 651137|Thaumarchaeota H Guanylyl transferase CofC like - - 2.7.7.68 ko:K14941 ko00680,ko01120,map00680,map01120 M00378 R09397 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CofC k59_851310_1 644966.Tmar_1815 2.32e-09 58.5 COG1129@1|root,COG4177@1|root,COG1129@2|Bacteria,COG4177@2|Bacteria,1UR00@1239|Firmicutes,24FGE@186801|Clostridia 186801|Clostridia P branched-chain amino acid transport system, permease component - - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_851310_2 1172190.M947_01990 9.59e-14 75.9 COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,42YD9@68525|delta/epsilon subdivisions,2YRGF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Periplasmic copper-binding protein (NosD) - - - - - - - - - - - - NosD k59_696429_1 1207076.ALAT01000184_gene2717 2.02e-05 47.0 2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,1S5VC@1236|Gammaproteobacteria,1Z0IW@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S Protein of unknown function (DUF4197) - - - - - - - - - - - - DUF4197 k59_696429_2 1869.MB27_10300 2.26e-17 81.3 COG0604@1|root,COG0604@2|Bacteria,2ID9Y@201174|Actinobacteria,4DH0J@85008|Micromonosporales 201174|Actinobacteria C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_1582106_1 436308.Nmar_1793 6.74e-133 386.0 COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_851313_1 187303.BN69_0997 0.000522 41.6 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,36Z6K@31993|Methylocystaceae 28211|Alphaproteobacteria C Transketolase, pyrimidine binding domain - - 1.2.4.1 ko:K00162 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_851313_2 330084.JNYZ01000030_gene179 2.65e-23 101.0 COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,4DXN0@85010|Pseudonocardiales 201174|Actinobacteria C 1-deoxy-D-xylulose-5-phosphate synthase bkdA - 1.2.4.1,1.2.4.4 ko:K00161,ko:K00166 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_488068_1 436308.Nmar_1008 1.11e-60 207.0 COG0458@1|root,COG0624@1|root,arCOG01107@2157|Archaea,arCOG01596@2157|Archaea 2157|Archaea EF ATP-grasp domain cxp2 - 3.4.17.11,3.5.1.18,6.3.2.4 ko:K01295,ko:K01439,ko:K01921,ko:K16181 ko00300,ko00473,ko00550,ko01100,ko01120,ko01230,ko01502,map00300,map00473,map00550,map01100,map01120,map01230,map01502 M00016 R01150,R02734,R10011 RC00064,RC00090,RC00096,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011 - - - ATP-grasp_3,CPSase_L_D2,Dala_Dala_lig_C,M20_dimer,Peptidase_M20 k59_1635750_1 314230.DSM3645_17966 6.61e-117 351.0 COG0129@1|root,COG0129@2|Bacteria,2IWXV@203682|Planctomycetes 203682|Planctomycetes H Belongs to the IlvD Edd family ilvD GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_746550_1 330214.NIDE0891 2.3e-111 328.0 COG0535@1|root,COG0535@2|Bacteria,3J0X6@40117|Nitrospirae 40117|Nitrospirae S Domain of unknown function (DUF3463) - - - - - - - - - - - - DUF3463,Radical_SAM k59_72224_1 436308.Nmar_0206 1.7e-31 121.0 COG1042@1|root,arCOG01340@2157|Archaea,41S6N@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18593 ko00720,ko01120,map00720,map01120 - R10758 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_72224_2 1229909.NSED_00835 2.56e-58 194.0 COG2368@1|root,arCOG02143@2157|Archaea,41SA0@651137|Thaumarchaeota 651137|Thaumarchaeota Q Vinylacetyl-CoA Delta-isomerase - - 4.2.1.120,5.3.3.3 ko:K14534 ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200 M00374,M00375 R03031,R10782 RC01857,RC03277 ko00000,ko00001,ko00002,ko01000 - - - HpaB,HpaB_N k59_1373567_1 1265313.HRUBRA_00786 6.86e-06 47.4 COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,1RRMA@1236|Gammaproteobacteria,1J4ZM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Transglutaminase/protease-like homologues - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_1373567_2 247633.GP2143_07424 1.82e-39 132.0 2E588@1|root,3300P@2|Bacteria,1N79I@1224|Proteobacteria,1SCYA@1236|Gammaproteobacteria,1J6XU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF5062) VVA0683 - - - - - - - - - - - DUF5062 k59_1373567_3 1286632.P278_03710 1.04e-51 166.0 COG2044@1|root,COG2044@2|Bacteria,4P2I4@976|Bacteroidetes,1I8SH@117743|Flavobacteriia 976|Bacteroidetes S DsrE/DsrF-like family - - - - - - - - - - - - DrsE k59_955261_1 555079.Toce_0259 1.89e-35 129.0 COG0122@1|root,COG0122@2|Bacteria,1V5KW@1239|Firmicutes,25BR2@186801|Clostridia 186801|Clostridia L endonuclease III - - 3.2.2.21 ko:K01247 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD k59_1428000_1 1172190.M947_08160 1.31e-39 143.0 COG0531@1|root,COG0531@2|Bacteria,1QXK2@1224|Proteobacteria,42PZW@68525|delta/epsilon subdivisions,2YNUI@29547|Epsilonproteobacteria 1224|Proteobacteria E amino acid transporter - - - - - - - - - - - - AA_permease_2 k59_1481655_1 237368.SCABRO_01061 1.2e-61 206.0 COG0111@1|root,COG0111@2|Bacteria,2IWX7@203682|Planctomycetes 203682|Planctomycetes EH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_1273704_1 880072.Desac_1311 1.55e-05 52.0 COG0457@1|root,COG0457@2|Bacteria,1QTM2@1224|Proteobacteria,43F3J@68525|delta/epsilon subdivisions,2X39C@28221|Deltaproteobacteria,2MSHJ@213462|Syntrophobacterales 880072.Desac_1311|- S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1428002_1 56780.SYN_02232 1.03e-92 282.0 COG1980@1|root,COG1980@2|Bacteria,1MXM7@1224|Proteobacteria,42YTY@68525|delta/epsilon subdivisions,2WTMS@28221|Deltaproteobacteria,2MRGZ@213462|Syntrophobacterales 28221|Deltaproteobacteria G Fructose-1,6-bisphosphatase - - 3.1.3.11,4.1.2.13 ko:K01622 ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00003 R00762,R01068,R01070,R02568,R04780 RC00017,RC00438,RC00439 ko00000,ko00001,ko00002,ko01000 - - - FBPase_3 k59_1582123_1 713587.THITH_11925 1.14e-48 159.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1WYAE@135613|Chromatiales 135613|Chromatiales F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_1582123_2 686340.Metal_1187 6.51e-29 106.0 COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1SAAA@1236|Gammaproteobacteria,1XFCJ@135618|Methylococcales 135618|Methylococcales P Rieske 2Fe-2S - - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske k59_851326_1 1282876.BAOK01000002_gene898 8.08e-46 159.0 COG1960@1|root,COG1960@2|Bacteria,1P8I7@1224|Proteobacteria,2U0AW@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_851326_2 1108045.GORHZ_071_00210 1.64e-27 114.0 COG1960@1|root,COG1960@2|Bacteria,2GKPG@201174|Actinobacteria,4GE8Z@85026|Gordoniaceae 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_590001_1 33876.JNXY01000029_gene2687 0.000648 47.8 COG2227@1|root,COG2227@2|Bacteria,2I2JK@201174|Actinobacteria 201174|Actinobacteria H Methyltransferase domain - - - - - - - - - - - - Acetyltransf_1,Methyltransf_11,Methyltransf_25 k59_277016_1 1297617.JPJD01000016_gene126 5.07e-20 97.4 COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,24A5F@186801|Clostridia,268Q9@186813|unclassified Clostridiales 186801|Clostridia S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_1582131_1 582744.Msip34_0247 6.56e-47 162.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,2KKBV@206350|Nitrosomonadales 206350|Nitrosomonadales S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_1582131_2 472759.Nhal_3473 2.21e-81 252.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,1WW5C@135613|Chromatiales 135613|Chromatiales V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_1319743_1 1229909.NSED_08340 3.18e-35 132.0 COG0031@1|root,COG0607@1|root,arCOG01430@2157|Archaea,arCOG02021@2157|Archaea,41SYY@651137|Thaumarchaeota 651137|Thaumarchaeota E Pyridoxal-phosphate dependent enzyme - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1319743_2 1131266.ARWQ01000001_gene1346 5.95e-11 65.1 arCOG08812@1|root,arCOG08812@2157|Archaea,41T0K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1439839_3 35754.JNYJ01000001_gene7136 3.5e-18 88.2 COG0132@1|root,COG0132@2|Bacteria,2GIZ2@201174|Actinobacteria,4DB72@85008|Micromonosporales 201174|Actinobacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - - AAA_26 k59_233181_1 187303.BN69_2742 7.08e-85 260.0 COG0451@1|root,COG0451@2|Bacteria,1MU1A@1224|Proteobacteria,2TU1A@28211|Alphaproteobacteria,370Y9@31993|Methylocystaceae 28211|Alphaproteobacteria GM Male sterility protein MA20_27225 - 1.1.1.410 ko:K22025 - - - - ko00000,ko01000 - - - Epimerase k59_286272_1 350054.Mflv_4332 2.86e-06 48.9 COG2072@1|root,COG2072@2|Bacteria,2GKYU@201174|Actinobacteria,233MC@1762|Mycobacteriaceae 201174|Actinobacteria P Flavoprotein involved in K transport - - 1.14.13.22,1.14.13.92 ko:K03379,ko:K18229 ko00930,ko01120,ko01220,map00930,map01120,map01220 - R02231,R06622 RC00662,RC01550 ko00000,ko00001,ko01000 - - - FMO-like,Pyr_redox_2,Pyr_redox_3 k59_706291_1 747365.Thena_0167 0.000109 50.4 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_1441202_1 1379270.AUXF01000005_gene661 3.62e-47 172.0 COG0060@1|root,COG0060@2|Bacteria,1ZSKS@142182|Gemmatimonadetes 142182|Gemmatimonadetes J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_1287422_1 330214.NIDE3405 3.29e-36 126.0 COG3212@1|root,COG3212@2|Bacteria 2|Bacteria T peptidase Z012_07375 - - - - - - - - - - - PepSY k59_1287422_2 330214.NIDE3406 3.88e-26 106.0 COG0129@1|root,COG0129@2|Bacteria,3J0ES@40117|Nitrospirae 40117|Nitrospirae EG Dehydratase family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_914074_2 1229909.NSED_00080 4.35e-51 168.0 COG1093@1|root,arCOG04107@2157|Archaea,41SHY@651137|Thaumarchaeota 651137|Thaumarchaeota J Translation initiation factor 2, alpha subunit - - - ko:K03237 ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168 - - - ko00000,ko00001,ko03012 - - - EIF_2_alpha,S1 k59_85636_1 1123392.AQWL01000002_gene1871 4.11e-81 261.0 COG3712@1|root,COG3712@2|Bacteria,1N941@1224|Proteobacteria,2VIKR@28216|Betaproteobacteria 28216|Betaproteobacteria PT Membrane - - - - - - - - - - - - FecR k59_1327394_1 1121935.AQXX01000133_gene3440 2.24e-12 66.6 COG0518@1|root,COG0518@2|Bacteria,1MV9U@1224|Proteobacteria,1S49E@1236|Gammaproteobacteria,1XHSX@135619|Oceanospirillales 135619|Oceanospirillales F Glutamine amidotransferase class-I - - - - - - - - - - - - GATase k59_501529_1 748247.AZKH_p0367 9.55e-63 206.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VH5N@28216|Betaproteobacteria 28216|Betaproteobacteria Q ABC-type transport system involved in resistance to organic solvents, permease component - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE,STAS_2 k59_660377_1 870187.Thini_0552 2.92e-94 288.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,45ZMN@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_706321_1 388401.RB2150_10776 4.08e-60 199.0 COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria,3ZI8B@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_445377_2 215803.DB30_7688 7.55e-18 85.9 COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42PIE@68525|delta/epsilon subdivisions,2WM3C@28221|Deltaproteobacteria,2YU0I@29|Myxococcales 28221|Deltaproteobacteria C Polysulphide reductase, NrfD actC - - ko:K00185 - - - - ko00000 5.A.3 - - DUF3341,NrfD k59_1494941_1 929556.Solca_3368 1.24e-20 95.9 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,4NE5M@976|Bacteroidetes,1IPWZ@117747|Sphingobacteriia 976|Bacteroidetes C Oxidoreductase nrfC - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molydop_binding k59_660413_1 1313421.JHBV01000041_gene3598 5.19e-40 145.0 COG4638@1|root,COG4638@2|Bacteria,4NYTC@976|Bacteroidetes 976|Bacteroidetes P Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_756641_1 235909.GK1754 1.54e-26 113.0 COG0661@1|root,COG0661@2|Bacteria,1TPIV@1239|Firmicutes,4HBW3@91061|Bacilli,1WFU6@129337|Geobacillus 91061|Bacilli S ABC1 family ubiB - - ko:K03688 - - - - ko00000 - - - ABC1,APH k59_660417_1 340435.A0A7S8_9CAUD 3.62e-09 60.5 4QB53@10239|Viruses,4QZ1A@35237|dsDNA viruses no RNA stage,4QSJ1@28883|Caudovirales,4QIMW@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_965086_1 357808.RoseRS_2964 1.58e-81 261.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2G7MP@200795|Chloroflexi,3760K@32061|Chloroflexia 32061|Chloroflexia C PFAM NADH flavin oxidoreductase NADH oxidase - - 1.5.8.1,1.5.8.2 ko:K00317 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R01588,R02511 RC00185,RC00556,RC00557,RC00732 ko00000,ko00001,ko01000 - - - Oxidored_FMN,Pyr_redox_2 k59_1327421_1 1469245.JFBG01000063_gene2351 2.44e-143 434.0 COG0112@1|root,COG0404@1|root,COG0112@2|Bacteria,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1WWZ0@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_1017890_1 1163617.SCD_n01987 9.26e-71 225.0 COG4398@1|root,COG4398@2|Bacteria,1RBRR@1224|Proteobacteria,2VQ7K@28216|Betaproteobacteria 28216|Betaproteobacteria S FIST_C - - - - - - - - - - - - FIST,FIST_C k59_132655_1 553385.JEMF01000021_gene3070 5.14e-23 103.0 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,1XI5C@135619|Oceanospirillales 135619|Oceanospirillales C COG2863 Cytochrome c553 cc4 - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_965090_1 1125863.JAFN01000001_gene1462 7.46e-126 386.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria 28221|Deltaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_817531_1 1245471.PCA10_55400 1.06e-67 219.0 COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1T9E0@1236|Gammaproteobacteria,1YCRP@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria GM NAD(P)H-binding - - - - - - - - - - - - Epimerase k59_11843_2 1173264.KI913949_gene3646 2.52e-101 309.0 COG0017@1|root,COG0017@2|Bacteria,1G015@1117|Cyanobacteria,1H7PZ@1150|Oscillatoriales 1117|Cyanobacteria J PFAM tRNA synthetases class II (D, K and N) asnS - 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_501597_1 371731.Rsw2DRAFT_1271 1.03e-53 190.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria V COG0577 ABC-type antimicrobial peptide transport system permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_132663_1 1123257.AUFV01000001_gene1515 1.43e-91 285.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1X3HE@135614|Xanthomonadales 135614|Xanthomonadales T Phosphate starvation protein PhoH - - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_547218_1 1223410.KN050846_gene2056 1.65e-66 217.0 COG1748@1|root,COG1748@2|Bacteria,4NFM8@976|Bacteroidetes,1HXRS@117743|Flavobacteriia 976|Bacteroidetes E Saccharopine dehydrogenase - - 1.5.1.10,1.5.1.7 ko:K00290,ko:K00293 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715,R02315 RC00215,RC00217,RC00225,RC01532 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_756657_1 268746.Q58MP1_BPPRM 6.7e-63 218.0 4QEE7@10239|Viruses,4QV59@35237|dsDNA viruses no RNA stage,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae 10662|Myoviridae S Pfam:DUF4815 - - - - - - - - - - - - - k59_1382818_1 444860.E3SIZ0_9CAUD 1.13e-96 304.0 4QF7I@10239|Viruses,4QYCA@35237|dsDNA viruses no RNA stage,4QT9A@28883|Caudovirales,4QKJH@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_11847_1 565045.NOR51B_964 9.37e-28 117.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - CHU_C,DUF11,DUF4157,PMT_2,WD40 k59_1592523_1 1232410.KI421413_gene712 1.15e-160 462.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,43SUZ@69541|Desulfuromonadales 28221|Deltaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt-1 - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_1592523_2 795666.MW7_1695 2.65e-31 117.0 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2VR4W@28216|Betaproteobacteria,1K3S0@119060|Burkholderiaceae 28216|Betaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_1592523_3 1150469.RSPPHO_02500 5.14e-08 52.4 COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,2U71N@28211|Alphaproteobacteria,2JSDI@204441|Rhodospirillales 204441|Rhodospirillales S EVE domain - - - - - - - - - - - - EVE k59_1070855_1 1229909.NSED_00070 3.4e-98 307.0 COG1287@1|root,arCOG02044@2157|Archaea,41SBI@651137|Thaumarchaeota 651137|Thaumarchaeota G Oligosaccharyl transferase STT3 subunit - - 2.4.99.18 ko:K07151 ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141 M00072 R04216,R05976 RC00005,RC00482 ko00000,ko00001,ko00002,ko01000,ko01003 - GT66 - STT3 k59_1532972_1 1073999.BN137_4020 5.98e-26 109.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria 1236|Gammaproteobacteria V (ABC) transporter ybhF GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_706373_1 330214.NIDE3226 1.8e-80 257.0 COG1164@1|root,COG1164@2|Bacteria 2|Bacteria E metalloendopeptidase activity pepF - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_600220_1 436308.Nmar_1714 2.49e-212 593.0 COG4591@1|root,arCOG02313@2157|Archaea,41TBB@651137|Thaumarchaeota 651137|Thaumarchaeota M FtsX-like permease family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_756678_1 269799.Gmet_2983 1.3e-43 160.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2WJ3W@28221|Deltaproteobacteria,43TIJ@69541|Desulfuromonadales 28221|Deltaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_756678_2 1157490.EL26_16835 5.5e-09 59.3 COG0611@1|root,COG0611@2|Bacteria,1V0SM@1239|Firmicutes,4HG10@91061|Bacilli,2794P@186823|Alicyclobacillaceae 91061|Bacilli H AIR synthase related protein, C-terminal domain thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU05900 AIRS,AIRS_C k59_1070866_1 608538.HTH_0156 8.14e-15 79.3 COG1148@1|root,COG1290@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1290@2|Bacteria,COG1908@2|Bacteria 2|Bacteria C Methyl-viologen-reducing hydrogenase, delta subunit napF - - ko:K02572,ko:K02573,ko:K03522 - - - - ko00000,ko04147 - - - CCG,Cytochrome_B,FAD_binding_6,Fer2,Fer4,Fer4_4,Fer4_5,Fer4_7,FlpD,NAD_binding_1 k59_1495008_1 1224318.DT73_10285 3.71e-15 72.4 COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,1RNKT@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the cytidylate kinase family. Type 1 subfamily cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO1391,iSDY_1059.SDY_2348 Cytidylate_kin k59_1495008_2 1397527.Q670_15480 7.39e-75 246.0 COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1XIJ8@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 1.3.1.12,2.5.1.19 ko:K00210,ko:K00800 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00022,M00025 R01728,R03460 RC00125,RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase,PDH k59_600227_1 697282.Mettu_1687 6.36e-92 276.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1XDSQ@135618|Methylococcales 135618|Methylococcales F SAICAR synthetase purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_287391_1 765913.ThidrDRAFT_2740 1.41e-61 214.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,1RR2P@1236|Gammaproteobacteria,1WXP6@135613|Chromatiales 135613|Chromatiales O O-linked N-acetylglucosamine transferase, SPINDLY family - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_600229_1 1469245.JFBG01000071_gene67 1.16e-73 232.0 COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,1RYFV@1236|Gammaproteobacteria,1X10G@135613|Chromatiales 135613|Chromatiales M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_1327459_1 1206743.BAGM01000101_gene2502 1.51e-16 75.1 COG4308@1|root,COG4308@2|Bacteria,2IP4X@201174|Actinobacteria,4G2E2@85025|Nocardiaceae 201174|Actinobacteria Q Limonene-1,2-epoxide hydrolase catalytic domain - - 3.3.2.8 ko:K10533 ko00903,map00903 - R05784,R09387 RC01473,RC02519 ko00000,ko00001,ko01000 - - - LEH k59_1327459_2 1101188.KI912157_gene155 4.75e-30 121.0 COG2303@1|root,COG2303@2|Bacteria,2I5YA@201174|Actinobacteria 201174|Actinobacteria E oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_85759_1 1415780.JPOG01000001_gene291 1.15e-11 73.6 COG3210@1|root,COG3210@2|Bacteria,1QZXD@1224|Proteobacteria,1T4BM@1236|Gammaproteobacteria,1XDH5@135614|Xanthomonadales 135614|Xanthomonadales U domain, Protein - - - - - - - - - - - - - k59_1441347_1 1033802.SSPSH_003276 1.54e-30 127.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Type II secretory pathway component ExeA - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_287403_1 472759.Nhal_0363 2.34e-72 240.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1X28I@135613|Chromatiales 135613|Chromatiales M Lysin motif - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_85774_1 342113.DM82_5337 6.78e-18 85.1 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VN3G@28216|Betaproteobacteria,1K49P@119060|Burkholderiaceae 28216|Betaproteobacteria J Amidase - - 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_85774_2 675812.VHA_002905 1.24e-20 93.2 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RMTS@1236|Gammaproteobacteria,1XSM6@135623|Vibrionales 135623|Vibrionales P Belongs to the ABC transporter superfamily - - 3.6.3.30 ko:K02010,ko:K02052 ko02010,ko02024,map02010,map02024 M00190,M00193 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10,3.A.1.11 - - ABC_tran,TOBE_2 k59_861729_1 644966.Tmar_0929 7.12e-74 250.0 COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,3WCF1@538999|Clostridiales incertae sedis 186801|Clostridia L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_1231891_2 1009370.ALO_12531 8.15e-22 93.6 COG4639@1|root,COG4639@2|Bacteria,1VMW4@1239|Firmicutes 1239|Firmicutes O Chromatin associated protein KTI12 - - - - - - - - - - - - AAA_33,HD k59_1327481_1 372461.BCc_019 1.42e-55 196.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,37CZY@32199|Buchnera 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_339652_1 396588.Tgr7_3228 1.67e-25 101.0 COG4967@1|root,COG4967@2|Bacteria,1N6TG@1224|Proteobacteria,1SC9Z@1236|Gammaproteobacteria,1WZQB@135613|Chromatiales 135613|Chromatiales NU TIGRFAM type IV pilus modification protein PilV - - - ko:K02671 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_339652_2 1121937.AUHJ01000015_gene155 3.67e-07 51.6 COG4970@1|root,COG4970@2|Bacteria,1N7RS@1224|Proteobacteria,1SCFB@1236|Gammaproteobacteria,468XR@72275|Alteromonadaceae 1236|Gammaproteobacteria NU COG4970 Tfp pilus assembly protein FimT fimT - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_287425_1 1032480.MLP_17760 4.63e-08 55.5 COG1233@1|root,COG1233@2|Bacteria,2GJAV@201174|Actinobacteria,4DQ0T@85009|Propionibacteriales 201174|Actinobacteria Q Flavin containing amine oxidoreductase crtI - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 - R04787,R04798,R04800,R09691,R09692 RC01214,RC02088,RC02605 ko00000,ko00001,ko01000 - - - Amino_oxidase k59_1287620_1 1230457.C476_15520 5.31e-05 44.7 COG0589@1|root,arCOG02053@2157|Archaea 2157|Archaea T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp k59_392980_1 118161.KB235919_gene6402 5.06e-46 162.0 2DMFF@1|root,32R5F@2|Bacteria,1GAQC@1117|Cyanobacteria 1117|Cyanobacteria S IMG reference gene - - - - - - - - - - - - - k59_1287626_1 1336803.PHEL49_1469 2.79e-37 135.0 COG1694@1|root,COG3956@2|Bacteria,4NEA3@976|Bacteroidetes,1HWKT@117743|Flavobacteriia,3VUZK@52959|Polaribacter 976|Bacteroidetes S MazG nucleotide pyrophosphohydrolase domain mazG - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - MazG k59_547296_1 439235.Dalk_1318 9.29e-71 216.0 COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,43BHF@68525|delta/epsilon subdivisions,2WQUJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_600295_1 261292.Nit79A3_1155 6.53e-53 187.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,373XP@32003|Nitrosomonadales 28216|Betaproteobacteria P Cation transporter/ATPase, N-terminus - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_660558_1 292415.Tbd_1069 2.75e-17 83.6 2EX35@1|root,33QE6@2|Bacteria,1NQZ5@1224|Proteobacteria,2W001@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1495106_2 1552123.EP57_14205 2.89e-25 103.0 COG0596@1|root,COG0596@2|Bacteria,1TS4C@1239|Firmicutes,4HB6G@91061|Bacilli,26K3M@186820|Listeriaceae 91061|Bacilli H Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) menH GO:0003674,GO:0003824,GO:0016787 4.2.99.20 ko:K08680 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08166 RC02148,RC02475 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_1649936_1 685778.AORL01000010_gene2909 1.94e-05 52.8 COG2244@1|root,COG2244@2|Bacteria,1R9I0@1224|Proteobacteria,2TV6V@28211|Alphaproteobacteria,2KD90@204457|Sphingomonadales 204457|Sphingomonadales S Membrane protein involved in the export of O-antigen and teichoic acid - - - ko:K03328 - - - - ko00000 2.A.66.2 - - Polysacc_synt_3 k59_767027_1 283942.IL1394 1.27e-18 90.5 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,2QFVW@267893|Idiomarinaceae 1236|Gammaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind k59_872098_1 290398.Csal_2005 5.97e-13 68.6 COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,1RRFQ@1236|Gammaproteobacteria,1XMB7@135619|Oceanospirillales 135619|Oceanospirillales D COG0003 Oxyanion-translocating ATPase arsA - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase k59_352579_1 1313265.JNIE01000004_gene418 2.32e-31 123.0 COG1924@1|root,COG1924@2|Bacteria,2G3VW@200783|Aquificae 200783|Aquificae I ATPase BadF BadG BcrA BcrD type - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_352579_2 1458427.BAWN01000012_gene706 1.85e-101 305.0 COG3580@1|root,COG3580@2|Bacteria 2|Bacteria I CoA-substrate-specific enzyme activase - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_609956_1 178901.AmDm5_1336 4.58e-12 61.6 COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,2TU1Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Domain of unknown function (DUF1989) - - - ko:K09967 - - - - ko00000 - - - DUF1989 k59_609956_2 1218084.BBJK01000075_gene5239 1.76e-42 158.0 COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1MVZZ@1224|Proteobacteria,2VXDK@28216|Betaproteobacteria,1K5E1@119060|Burkholderiaceae 28216|Betaproteobacteria K Bacterial transcriptional activator domain - - - - - - - - - - - - BTAD k59_675960_1 189753.AXAS01000017_gene3146 1.35e-21 94.4 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,3JSY1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_976103_1 1459636.NTE_02516 1.25e-12 65.5 COG1714@1|root,arCOG03633@2157|Archaea,41T5P@651137|Thaumarchaeota 651137|Thaumarchaeota S membrane protein domain - - - - - - - - - - - - RDD k59_976103_2 224914.BMEII1117 1.64e-06 53.1 COG1309@1|root,COG1309@2|Bacteria,1MZ9E@1224|Proteobacteria,2U0MU@28211|Alphaproteobacteria,1J2DI@118882|Brucellaceae 28211|Alphaproteobacteria K AefR-like transcriptional repressor, C-terminal region - - - - - - - - - - - - TetR_C_7,TetR_N k59_144759_1 981384.AEYW01000001_gene1611 8.61e-83 263.0 COG5598@1|root,COG5598@2|Bacteria,1N18H@1224|Proteobacteria,2U1XN@28211|Alphaproteobacteria,4ND2J@97050|Ruegeria 28211|Alphaproteobacteria H Trimethylamine methyltransferase (MTTB) - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB k59_872107_1 1163398.AJJP01000001_gene3322 3.47e-113 333.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria 1236|Gammaproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0042380,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046490,GO:0048037,GO:0051536,GO:0051538,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - iECIAI1_1343.ECIAI1_0030,iECW_1372.ECW_m0028,iEKO11_1354.EKO11_3884,iEcHS_1320.EcHS_A0031,iEcolC_1368.EcolC_3626,iPC815.YPO0477,iSFV_1184.SFV_0023,iSF_1195.SF0026,iSFxv_1172.SFxv_0027,iS_1188.S0028,iWFL_1372.ECW_m0028,iYL1228.KPN_00024 LYTB k59_352591_1 1120999.JONM01000001_gene1070 7.72e-26 112.0 COG0348@1|root,COG1251@1|root,COG0348@2|Bacteria,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2VIEA@28216|Betaproteobacteria,2KSEV@206351|Neisseriales 28216|Betaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.18.1.1 ko:K05297 ko00071,map00071 - R02000 - ko00000,ko00001,ko01000 - - - Fer2,Pyr_redox_2 k59_1028526_1 1120985.AUMI01000015_gene1386 2.09e-45 162.0 COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,4H31K@909932|Negativicutes 909932|Negativicutes E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_717599_1 1237149.C900_00396 9.12e-50 166.0 COG1280@1|root,COG1280@2|Bacteria,4NEG3@976|Bacteroidetes,47R5D@768503|Cytophagia 976|Bacteroidetes E LysE type translocator - - - - - - - - - - - - LysE k59_1337367_1 713586.KB900536_gene1196 1.24e-69 224.0 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,1RNTZ@1236|Gammaproteobacteria,1WXXP@135613|Chromatiales 135613|Chromatiales O Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_1602041_1 1223544.GSI01S_11_00550 1.11e-31 127.0 COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria,4GDID@85026|Gordoniaceae 201174|Actinobacteria C Glutamate/Leucine/Phenylalanine/Valine dehydrogenase dghA - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_1451317_1 1056820.KB900685_gene2787 1.02e-47 163.0 COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,1RP7G@1236|Gammaproteobacteria,2PMH0@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M Male sterility protein rmlB GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008460,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_1451317_2 585502.HMPREF0645_1018 5.73e-08 55.1 COG1091@1|root,COG1091@2|Bacteria,4NE3K@976|Bacteroidetes,2FN7H@200643|Bacteroidia 976|Bacteroidetes M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_1602044_1 1121405.dsmv_2076 6e-45 156.0 COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,42QPA@68525|delta/epsilon subdivisions,2WMPU@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_558508_1 1122929.KB908217_gene140 2.27e-09 57.0 COG5453@1|root,COG5453@2|Bacteria,1N7WA@1224|Proteobacteria,2UFN1@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Transcriptional activator HlyU hlyU - - - - - - - - - - - HlyU k59_558508_2 298386.PBPRB0645 6.33e-67 222.0 COG0348@1|root,COG0348@2|Bacteria,1N605@1224|Proteobacteria 1224|Proteobacteria C COG0348 Polyferredoxin vnfA - - - - - - - - - - - Fer4_5 k59_1663857_2 1530186.JQEY01000015_gene363 1.07e-12 67.8 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the DEAD box helicase family rhlE - 3.6.4.13 ko:K03732,ko:K11927 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C k59_187917_1 1122134.KB893650_gene1723 1.34e-49 173.0 COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,1XI9B@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis aguA - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph k59_187917_2 530564.Psta_2478 2.1e-57 187.0 COG0388@1|root,COG0388@2|Bacteria,2IX91@203682|Planctomycetes 203682|Planctomycetes S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_609996_1 491952.Mar181_2759 6.42e-49 173.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1RMXU@1236|Gammaproteobacteria,1XI4B@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP - - ko:K03307,ko:K11928 - - - - ko00000,ko02000 2.A.21,2.A.21.2 - - SSF k59_872148_1 1229909.NSED_05600 3.12e-29 112.0 COG0668@1|root,arCOG01568@2157|Archaea,41T3B@651137|Thaumarchaeota 651137|Thaumarchaeota M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_833170_1 570952.ATVH01000013_gene2643 3.62e-59 197.0 COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2TQQB@28211|Alphaproteobacteria,2JPFF@204441|Rhodospirillales 204441|Rhodospirillales L Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_187930_1 105559.Nwat_1801 1.61e-92 286.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1WWMF@135613|Chromatiales 135613|Chromatiales O PFAM Magnesium chelatase, ChlI subunit - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_457927_1 1122135.KB893137_gene1217 1.1e-66 218.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2U4XB@28211|Alphaproteobacteria 28211|Alphaproteobacteria P MgtE intracellular N domain - - - - - - - - - - - - CBS,MgtE,MgtE_N k59_1244044_2 1041146.ATZB01000034_gene561 1.33e-17 79.3 COG3462@1|root,COG3462@2|Bacteria,1NGXC@1224|Proteobacteria,2V9XZ@28211|Alphaproteobacteria,4BKA0@82115|Rhizobiaceae 28211|Alphaproteobacteria S Short C-terminal domain - - - ko:K08982 - - - - ko00000 - - - SHOCT k59_517151_1 1197906.CAJQ02000053_gene4320 9.89e-06 47.0 COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2TSGJ@28211|Alphaproteobacteria,3JRUB@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Branched-chain amino acid transport system / permease component - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_517151_2 1123256.KB907952_gene3164 1.22e-47 163.0 COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,1RS4S@1236|Gammaproteobacteria,1X9AR@135614|Xanthomonadales 135614|Xanthomonadales S Branched-chain amino acid transport system / permease component - - - - - - - - - - - - BPD_transp_2 k59_976154_1 330214.NIDE4028 8.43e-114 346.0 COG0443@1|root,COG0443@2|Bacteria,3J0YD@40117|Nitrospirae 40117|Nitrospirae O Hsp70 protein hscA - - ko:K04043,ko:K04044 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33,1.A.33.1 - - HSP70 k59_187932_1 313628.LNTAR_23119 1.19e-47 172.0 COG3119@1|root,COG3119@2|Bacteria 2|Bacteria P arylsulfatase activity - - - - - - - - - - - - DUF4976,Sulfatase k59_1451339_1 251229.Chro_4341 1.84e-27 109.0 COG0363@1|root,COG0363@2|Bacteria,1G20H@1117|Cyanobacteria,3VI27@52604|Pleurocapsales 1117|Cyanobacteria G PFAM Glucosamine-6-phosphate isomerases 6-phosphogluconolactonase pgl GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_1451344_1 1232410.KI421417_gene2752 2.7e-67 219.0 COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria,43S30@69541|Desulfuromonadales 28221|Deltaproteobacteria G Glycosyltransferase family 20 otsAB - 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,S6PP,Trehalose_PPase k59_1510598_1 871968.DESME_11880 1.18e-33 129.0 COG1281@1|root,COG1281@2|Bacteria,1TRCH@1239|Firmicutes,24940@186801|Clostridia,260G9@186807|Peptococcaceae 186801|Clostridia O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress hslO - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 k59_872167_1 1336245.JAGO01000011_gene551 1.08e-20 94.4 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1XHWC@135619|Oceanospirillales 135619|Oceanospirillales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_300548_1 1121035.AUCH01000001_gene1933 1.08e-36 135.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2VH94@28216|Betaproteobacteria,2KVMS@206389|Rhodocyclales 206389|Rhodocyclales OU signal peptide peptidase - - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_1084099_1 331869.BAL199_04764 2.34e-94 304.0 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,4BPQ6@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the GcvT family soxA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.5.3.1 ko:K00302 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2 k59_17575_1 543632.JOJL01000068_gene3305 1.13e-69 222.0 COG1236@1|root,COG1236@2|Bacteria,2HEXB@201174|Actinobacteria,4DB1K@85008|Micromonosporales 201174|Actinobacteria J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL k59_1181199_1 330214.NIDE3982 6.37e-23 95.5 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator - - - ko:K02282 - - - - ko00000,ko02035,ko02044 - - - GerE,Response_reg k59_1542850_2 1245471.PCA10_03440 9.85e-17 77.8 COG0835@1|root,COG0835@2|Bacteria,1RCIR@1224|Proteobacteria,1S61F@1236|Gammaproteobacteria,1YCQV@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria NT Two component signalling adaptor domain pilI - - ko:K02659 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - CheW k59_1181995_1 395493.BegalDRAFT_2422 2.89e-54 185.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,45ZZU@72273|Thiotrichales 72273|Thiotrichales S Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1393612_1 1197951.I6S6K3_9CAUD 3.06e-14 80.1 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales 28883|Caudovirales S N-acetylmuramoyl-L-alanine amidase activity - - - - - - - - - - - - - k59_458925_1 330214.NIDE0426 8.04e-147 428.0 COG0539@1|root,COG1185@1|root,COG0539@2|Bacteria,COG1185@2|Bacteria,3J0CA@40117|Nitrospirae 40117|Nitrospirae J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_873158_1 1229780.BN381_410014 1.14e-61 205.0 COG1042@1|root,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria 201174|Actinobacteria C CoA-binding domain protein acdA1 - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_1602749_1 713586.KB900536_gene1193 2.6e-43 151.0 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,1S8R3@1236|Gammaproteobacteria,1WZ62@135613|Chromatiales 135613|Chromatiales M Transglycosylase SLT domain - - - - - - - - - - - - DUF4124,SLT k59_1665321_1 717773.Thicy_1674 2.68e-63 205.0 COG0500@1|root,COG0500@2|Bacteria,1MVSK@1224|Proteobacteria,1RMQY@1236|Gammaproteobacteria,4603J@72273|Thiotrichales 72273|Thiotrichales J Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs cmoB - - ko:K15257 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_9 k59_928596_1 395494.Galf_1762 9.12e-39 140.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2W3RM@28216|Betaproteobacteria,44VN6@713636|Nitrosomonadales 28216|Betaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1543860_1 1232683.ADIMK_2782 5.88e-22 93.2 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,464TG@72275|Alteromonadaceae 1236|Gammaproteobacteria M Arabinose 5-phosphate isomerase kdsD GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0019146,GO:0019294,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0046364,GO:0046394,GO:0046400,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECH74115_1262.ECH74115_4519,iECSP_1301.ECSP_4172,iECs_1301.ECs4076,iPC815.YPO3577,iSFV_1184.SFV_3227,iSFxv_1172.SFxv_3550,iYL1228.KPN_03607,iZ_1308.Z4560 CBS,SIS k59_1543860_2 2340.JV46_29440 7.65e-84 251.0 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,1J685@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate kdsC GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008781,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016311,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016791,GO:0019143,GO:0033692,GO:0034637,GO:0034645,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECO26_1355.ECO26_4302 Hydrolase_3 k59_458930_1 1144275.COCOR_06731 1.79e-86 273.0 COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 k59_1304452_1 1122165.AUHS01000012_gene2814 1.57e-59 196.0 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria,1JE1A@118969|Legionellales 118969|Legionellales M Barrel-sandwich domain of CusB or HlyD membrane-fusion cebB - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - HlyD_D23,HlyD_D4 k59_677499_1 1234664.AMRO01000022_gene1649 2.27e-08 57.8 COG1960@1|root,COG1960@2|Bacteria,1TTAR@1239|Firmicutes,4HE7T@91061|Bacilli,1WF0T@129337|Geobacillus 91061|Bacilli I Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_611011_1 573370.DMR_25420 6.88e-53 182.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,42N6C@68525|delta/epsilon subdivisions,2WJ66@28221|Deltaproteobacteria,2M93K@213115|Desulfovibrionales 28221|Deltaproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_301587_1 323261.Noc_2508 2.83e-29 113.0 COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,1RQWC@1236|Gammaproteobacteria,1WWH8@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0229 family - - - ko:K09786 - - - - ko00000 - - - DUF444 k59_768093_1 589865.DaAHT2_0905 1.03e-52 181.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,42MND@68525|delta/epsilon subdivisions,2WJC3@28221|Deltaproteobacteria,2MIG5@213118|Desulfobacterales 28221|Deltaproteobacteria E Bacterial transferase hexapeptide (six repeats) cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_1245036_2 1201290.M902_1625 8.57e-06 49.7 COG2159@1|root,COG2159@2|Bacteria,1R7E1@1224|Proteobacteria,42S40@68525|delta/epsilon subdivisions,2WNAU@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Amidohydrolase 2 - - - - - - - - - - - - Amidohydro_2 k59_257063_1 877455.Metbo_1265 4.19e-55 182.0 COG1635@1|root,arCOG00574@2157|Archaea,2XTXH@28890|Euryarchaeota 28890|Euryarchaeota H Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur thi4 - - ko:K03146 ko00730,ko01100,map00730,map01100 - R10685 RC00033,RC03253,RC03254 ko00000,ko00001 - - - Thi4 k59_1350377_1 243231.GSU2225 1.13e-20 95.1 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,42M3N@68525|delta/epsilon subdivisions,2WISS@28221|Deltaproteobacteria,43U5B@69541|Desulfuromonadales 28221|Deltaproteobacteria J GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_1405714_1 525244.HMPREF0023_0426 1.01e-12 63.9 COG0393@1|root,COG0393@2|Bacteria,1RJ73@1224|Proteobacteria,1S6S1@1236|Gammaproteobacteria,3NNHZ@468|Moraxellaceae 1236|Gammaproteobacteria S Belongs to the UPF0145 family - - - - - - - - - - - - YbjQ_1 k59_1405714_2 998674.ATTE01000001_gene213 2.85e-44 150.0 COG0393@1|root,COG0393@2|Bacteria,1N6BK@1224|Proteobacteria,1SAFJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0145 family - - - - - - - - - - - - YbjQ_1 k59_417150_1 349102.Rsph17025_2221 6.31e-60 199.0 COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2TQZC@28211|Alphaproteobacteria,1FCGY@1060|Rhodobacter 28211|Alphaproteobacteria E Periplasmic binding protein - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_570090_2 56780.SYN_00530 1.54e-34 127.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,42P3I@68525|delta/epsilon subdivisions,2WM37@28221|Deltaproteobacteria,2MQHP@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_365394_1 381666.H16_B0644 1.18e-74 241.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VIQJ@28216|Betaproteobacteria,1K0RJ@119060|Burkholderiaceae 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.41 ko:K18687 ko00984,ko01100,ko01120,map00984,map01100,map01120 - R10769 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_570099_1 247633.GP2143_07849 3.65e-96 304.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1J4YH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG4985 ABC-type phosphate transport system, auxiliary component pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_1556762_1 87626.PTD2_17017 1.08e-107 333.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,2Q14R@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_417210_1 215803.DB30_0647 5.99e-282 812.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2YUJI@29|Myxococcales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1350438_1 394.NGR_c34800 1.63e-18 84.3 COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,2TR1Y@28211|Alphaproteobacteria,4B8E7@82115|Rhizobiaceae 28211|Alphaproteobacteria P ABC transporter permease yejE GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944 - ko:K13895 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - BPD_transp_1,OppC_N k59_1350438_2 1123229.AUBC01000003_gene2010 6.93e-57 186.0 COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,2TQJD@28211|Alphaproteobacteria,3JRWI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Binding-protein-dependent transport system inner membrane component yejB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0022857,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944 - ko:K13894 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - BPD_transp_1 k59_365430_1 1121403.AUCV01000004_gene2051 4.75e-07 56.6 COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,42TV7@68525|delta/epsilon subdivisions,2WRW0@28221|Deltaproteobacteria 28221|Deltaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TPR_6,YkuD k59_365430_2 443143.GM18_3524 3.21e-21 94.4 COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,42S95@68525|delta/epsilon subdivisions,2WNPS@28221|Deltaproteobacteria,43SFI@69541|Desulfuromonadales 28221|Deltaproteobacteria S L,D-transpeptidase catalytic domain - - - ko:K16291 - - - - ko00000,ko01002,ko01011 - - - LysM,YkuD k59_1194295_1 8049.ENSGMOP00000004059 7.02e-06 47.8 COG0154@1|root,KOG1212@2759|Eukaryota,38EEG@33154|Opisthokonta,3BBQA@33208|Metazoa,3CZRX@33213|Bilateria,48B9B@7711|Chordata,497UN@7742|Vertebrata,49XXK@7898|Actinopterygii 33208|Metazoa IJT amide hydrolase FAAH2 GO:0001676,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005811,GO:0006082,GO:0006629,GO:0006631,GO:0006690,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017064,GO:0019369,GO:0019752,GO:0032787,GO:0033559,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044464,GO:0071704,GO:1901568 3.5.1.99 ko:K19176 - - - - ko00000,ko01000 - - - Amidase k59_1194301_1 436308.Nmar_0585 5.22e-29 105.0 arCOG10530@1|root,arCOG10530@2157|Archaea,41T2M@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1405818_1 330214.NIDE2915 4.61e-107 324.0 COG0064@1|root,COG0064@2|Bacteria,3J0FK@40117|Nitrospirae 40117|Nitrospirae J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_417288_2 33898.JRHJ01000055_gene5909 4.15e-27 113.0 296TN@1|root,2ZU2M@2|Bacteria,2IB0Z@201174|Actinobacteria 201174|Actinobacteria S Sulfotransferase family - - - ko:K18571 ko00332,ko01130,map00332,map01130 - R10751 RC00007,RC00518 ko00000,ko00001,ko01000 - - - Sulfotransfer_3 k59_1556862_1 1282876.BAOK01000002_gene536 5.89e-202 569.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria,4BPRD@82117|unclassified Alphaproteobacteria 2|Bacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_23080_1 9913.ENSBTAP00000006821 5.37e-13 69.3 COG2096@1|root,2QS64@2759|Eukaryota,399ET@33154|Opisthokonta,3BDEZ@33208|Metazoa,3CZ9D@33213|Bilateria,48670@7711|Chordata,491CZ@7742|Vertebrata,3JCJ8@40674|Mammalia,4IZ82@91561|Cetartiodactyla 33208|Metazoa S cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial MMAB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008817,GO:0009235,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0019842,GO:0031419,GO:0031974,GO:0033013,GO:0036094,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046906,GO:0048037,GO:0051186,GO:0070013,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_23080_2 640510.BC1001_0761 4.47e-28 110.0 COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,2VJ7T@28216|Betaproteobacteria,1K1P1@119060|Burkholderiaceae 28216|Betaproteobacteria P Periplasmic binding protein btuF - - ko:K02016,ko:K06858 ko02010,map02010 M00240,M00241 - - ko00000,ko00001,ko00002,ko02000 3.A.1.13,3.A.1.14 - - Peripla_BP_2 k59_1040089_1 1278073.MYSTI_05120 1.05e-16 77.8 COG0848@1|root,COG0848@2|Bacteria,1Q5DA@1224|Proteobacteria,42VMC@68525|delta/epsilon subdivisions,2X5N3@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Biopolymer transport protein - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_1040089_2 234267.Acid_0509 6.11e-13 71.6 COG0811@1|root,COG0811@2|Bacteria,3Y2T8@57723|Acidobacteria 57723|Acidobacteria U MotA TolQ ExbB proton channel - - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_417331_1 96561.Dole_1148 4.14e-51 175.0 COG4269@1|root,COG4269@2|Bacteria,1MW5P@1224|Proteobacteria,42R97@68525|delta/epsilon subdivisions,2WMRA@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Bacterial protein of unknown function (DUF898) - - - - - - - - - - - - DUF898 k59_1556894_1 1449976.KALB_6004 1.07e-35 137.0 COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria,4E0Y6@85010|Pseudonocardiales 201174|Actinobacteria S Amidohydrolase family nfdA_1 - - - - - - - - - - - Amidohydro_3 k59_988127_1 251221.35213997 8.55e-22 99.0 COG0768@1|root,COG0768@2|Bacteria,1G03W@1117|Cyanobacteria 1117|Cyanobacteria M Cell division protein FtsI penicillin-binding protein 2 mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_988137_1 378806.STAUR_5923 4.07e-09 58.2 COG2259@1|root,COG2259@2|Bacteria,1NCQT@1224|Proteobacteria,42WUM@68525|delta/epsilon subdivisions,2WT9R@28221|Deltaproteobacteria,2YW52@29|Myxococcales 28221|Deltaproteobacteria S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX k59_202459_1 118168.MC7420_4867 2.18e-60 209.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1G2UN@1117|Cyanobacteria,1H977@1150|Oscillatoriales 1117|Cyanobacteria G Alpha amylase, catalytic domain - - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - APH,Alpha-amylase,Malt_amylase_C k59_202459_2 876269.ARWA01000001_gene477 1e-19 89.4 COG0366@1|root,COG1640@1|root,COG0366@2|Bacteria,COG1640@2|Bacteria,1MWBZ@1224|Proteobacteria,2TVJ1@28211|Alphaproteobacteria,3NC98@45404|Beijerinckiaceae 28211|Alphaproteobacteria G Domain of unknown function (DUF3416) glgE - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3416,Malt_amylase_C k59_365537_2 1207063.P24_00590 3.1e-27 105.0 COG1173@1|root,COG1173@2|Bacteria,1MU7Z@1224|Proteobacteria,2TTM9@28211|Alphaproteobacteria,2JRFQ@204441|Rhodospirillales 204441|Rhodospirillales EP Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1,OppC_N k59_778335_1 323261.Noc_1374 1.83e-06 50.1 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1WXBQ@135613|Chromatiales 135613|Chromatiales O PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_365542_2 756272.Plabr_2883 1.95e-52 181.0 COG0515@1|root,COG0515@2|Bacteria,2J2D5@203682|Planctomycetes 203682|Planctomycetes KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_780168_1 55952.BU52_11910 7.32e-52 172.0 COG0379@1|root,COG0379@2|Bacteria,2GKCM@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate - - - - - - - - - - - - - k59_780168_2 247490.KSU1_D0287 3.01e-23 97.4 COG1216@1|root,COG1216@2|Bacteria,2IZV9@203682|Planctomycetes 203682|Planctomycetes S Glycosyl transferase, family 2 - - - - - - - - - - - - Glycos_transf_2 k59_205626_1 40571.JOEA01000006_gene4543 4.24e-83 268.0 COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4E2A3@85010|Pseudonocardiales 201174|Actinobacteria Q Wax ester synthase-like Acyl-CoA acyltransferase domain - - - - - - - - - - - - DUF1298,WES_acyltransf k59_885416_2 1458357.BG58_40830 2.33e-11 61.6 COG0236@1|root,COG0236@2|Bacteria,1N7Q1@1224|Proteobacteria,2VVRR@28216|Betaproteobacteria,1K9MR@119060|Burkholderiaceae 28216|Betaproteobacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpM - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_259296_1 1298593.TOL_2306 1.34e-13 72.8 COG3103@1|root,COG4991@2|Bacteria,1MX7M@1224|Proteobacteria,1RS74@1236|Gammaproteobacteria,1XKNE@135619|Oceanospirillales 135619|Oceanospirillales T Bacterial SH3 domain homologues - - - ko:K07184 - - - - ko00000 - - - SH3_3 k59_1196724_1 1179773.BN6_63410 4.32e-13 67.8 COG0816@1|root,COG0816@2|Bacteria,2IQB0@201174|Actinobacteria,4E3CY@85010|Pseudonocardiales 201174|Actinobacteria L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA ruvX GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_1196724_2 330214.NIDE1707 9.92e-43 155.0 COG0013@1|root,COG0013@2|Bacteria,3J0D3@40117|Nitrospirae 40117|Nitrospirae J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_572350_1 1283300.ATXB01000001_gene1690 2.52e-44 157.0 COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,1SEED@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1613257_1 1000565.METUNv1_01394 5.46e-81 261.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,2KV9E@206389|Rhodocyclales 206389|Rhodocyclales C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_1408224_1 1485545.JQLW01000005_gene1167 8.36e-73 245.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria 1224|Proteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_885446_1 1344012.ATMI01000013_gene2598 5.11e-33 127.0 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria,4BU1S@82986|Tatumella 1236|Gammaproteobacteria M Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides - - - - - - - - - - - - Glycos_transf_2 k59_1613293_1 1040986.ATYO01000009_gene2306 1.35e-34 132.0 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,43KJI@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I acetyl-coa acetyltransferase - - - - - - - - - - - - - k59_1408284_1 436308.Nmar_1705 3.67e-37 130.0 COG0528@1|root,arCOG00858@2157|Archaea,41T1R@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_1408284_2 436308.Nmar_1706 1.26e-65 211.0 COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota 651137|Thaumarchaeota S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06885 - - - - ko00000 - - - HD k59_780291_1 584708.Apau_0801 1.78e-99 303.0 COG0112@1|root,COG0112@2|Bacteria,3TAB6@508458|Synergistetes 508458|Synergistetes E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_572442_1 1162668.LFE_1649 6.6e-25 108.0 COG1109@1|root,COG1109@2|Bacteria,3J0AF@40117|Nitrospirae 40117|Nitrospirae G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1196839_1 502025.Hoch_2631 2.17e-153 451.0 COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,42QCJ@68525|delta/epsilon subdivisions,2WKE7@28221|Deltaproteobacteria,2YUF8@29|Myxococcales 28221|Deltaproteobacteria G Glycosyl hydrolases family 15 - - - - - - - - - - - - DUF547,Glyco_hydro_15 k59_24021_1 1248916.ANFY01000007_gene2588 1.52e-63 203.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TQR9@28211|Alphaproteobacteria,2K6X7@204457|Sphingomonadales 204457|Sphingomonadales EH Amino-transferase class IV - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_572474_1 63737.Npun_F5467 1.16e-81 273.0 COG2202@1|root,COG3852@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3852@2|Bacteria,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria,1HTQ5@1161|Nostocales 1117|Cyanobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - CHASE4,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_572498_1 925775.XVE_0957 1.75e-94 290.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1X3HB@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_1196898_1 305900.GV64_02490 4.4e-54 188.0 COG0204@1|root,COG3176@1|root,COG0204@2|Bacteria,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,1RQD4@1236|Gammaproteobacteria,1XHPJ@135619|Oceanospirillales 135619|Oceanospirillales I phospholipid glycerol acyltransferase - - - - - - - - - - - - Acetyltransf_5,Acyltransferase k59_991729_2 1048834.TC41_1598 3.32e-87 276.0 COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,4HAJ6@91061|Bacilli,278SV@186823|Alicyclobacillaceae 91061|Bacilli S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_259504_1 445686.E3SL79_9CAUD 4.11e-60 207.0 4QAYA@10239|Viruses,4QRZE@28883|Caudovirales,4QIAY@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1613394_1 926549.KI421517_gene3817 6.96e-83 266.0 COG0457@1|root,COG0457@2|Bacteria,4NFIY@976|Bacteroidetes,47MEE@768503|Cytophagia 976|Bacteroidetes S Peptidase family M49 - - 3.4.14.4 ko:K01277 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M49 k59_1353124_1 1274524.BSONL12_07582 0.000926 41.6 COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,4HA7P@91061|Bacilli,1ZB0H@1386|Bacillus 91061|Bacilli E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_1353124_2 396588.Tgr7_2758 3.07e-46 152.0 COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,1WYGS@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H k59_1353125_1 1111479.AXAR01000003_gene1578 2.16e-08 57.0 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HB73@91061|Bacilli,2788T@186823|Alicyclobacillaceae 91061|Bacilli I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K13767 ko00071,ko00362,ko01100,ko01120,ko01212,map00071,map00362,map01100,map01120,map01212 M00087 R03026,R04170,R04738,R04740,R04744,R04746 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_572570_1 352165.HMPREF7215_0613 2.44e-05 50.1 COG1076@1|root,COG1076@2|Bacteria,3TBK1@508458|Synergistetes 508458|Synergistetes O DnaJ domain - - - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ k59_206050_1 55529.EKX43257 9.48e-75 236.0 COG0317@1|root,KOG1157@2759|Eukaryota 2759|Eukaryota KT HD domain containing 3 - - - - - - - - - - - - ACT_4,HD_4,RNA_pol_Rpb6,RelA_SpoT,TGS k59_736964_1 1411123.JQNH01000001_gene171 9.73e-89 291.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E glutamate synthase gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_214566_1 512565.AMIS_11460 2.13e-34 133.0 COG0536@1|root,COG0536@2|Bacteria,2GISB@201174|Actinobacteria,4D9WG@85008|Micromonosporales 201174|Actinobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904 - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - DUF1967,GTP1_OBG,MMR_HSR1 k59_1572474_1 580332.Slit_0977 2.22e-99 298.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2VH6N@28216|Betaproteobacteria,44VD1@713636|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_893978_1 1096546.WYO_2573 8.81e-32 125.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2TQMD@28211|Alphaproteobacteria,1JSUN@119045|Methylobacteriaceae 28211|Alphaproteobacteria GM PFAM NAD-dependent epimerase dehydratase MA20_24380 - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - 3Beta_HSD,Epimerase,NAD_binding_10,RmlD_sub_bind k59_109767_1 391615.ABSJ01000032_gene721 1.63e-36 137.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1J5GI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097 Mur_ligase_C,Mur_ligase_M k59_109767_2 666681.M301_2423 1.44e-26 109.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria,2KM9S@206350|Nitrosomonadales 206350|Nitrosomonadales M Peptidoglycan polymerase that is essential for cell division ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_214574_2 522306.CAP2UW1_1590 3.29e-46 166.0 COG0296@1|root,COG1523@1|root,COG0296@2|Bacteria,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria 28216|Betaproteobacteria G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_527885_1 1476876.JOJO01000011_gene3469 8.27e-138 410.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_2917_1 765914.ThisiDRAFT_1581 5.31e-66 207.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1WYD7@135613|Chromatiales 135613|Chromatiales O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_893980_1 880072.Desac_2842 5.12e-57 189.0 COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,42MUE@68525|delta/epsilon subdivisions,2WJFZ@28221|Deltaproteobacteria,2MR9K@213462|Syntrophobacterales 28221|Deltaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - rve k59_841535_1 330214.NIDE3276 1.63e-109 332.0 COG1032@1|root,COG1032@2|Bacteria 2|Bacteria C radical SAM domain protein - - - - - - - - - - - - B12-binding,PqqD,Radical_SAM k59_214576_1 1121861.KB899913_gene2259 4.39e-174 492.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2JQBC@204441|Rhodospirillales 204441|Rhodospirillales EP Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_214576_2 1298920.KI911353_gene1426 5.71e-07 52.4 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,21YFW@1506553|Lachnoclostridium 186801|Clostridia P Psort location CytoplasmicMembrane, score 9.49 - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_1154922_1 436308.Nmar_1794 2.86e-97 313.0 COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC - 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - PolC_DP2 k59_893983_1 1049564.TevJSym_al00610 1.66e-16 76.3 COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ52@1236|Gammaproteobacteria,1JBRE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NapC/NirT cytochrome c family, N-terminal region torC - - ko:K02569,ko:K03532 ko02020,map02020 - - - ko00000,ko00001,ko02000 5.A.3.4 - - Cytochrom_NNT,DHC k59_1261895_1 1382358.JHVN01000001_gene1242 7.2e-06 52.8 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HA52@91061|Bacilli,21WT6@150247|Anoxybacillus 91061|Bacilli T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) vicK - 2.7.13.3 ko:K07652 ko02020,map02020 M00459 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_9 k59_1470024_1 765913.ThidrDRAFT_1367 1.71e-36 133.0 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1WW0G@135613|Chromatiales 135613|Chromatiales J An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_1470024_2 497321.C664_06908 5.35e-58 191.0 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,2VJUC@28216|Betaproteobacteria,2KW9J@206389|Rhodocyclales 206389|Rhodocyclales L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_1470024_3 472759.Nhal_2439 2.52e-70 219.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1WXFG@135613|Chromatiales 135613|Chromatiales H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ - 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_161251_1 330214.NIDE3807 2.28e-06 48.5 COG0396@1|root,COG0396@2|Bacteria,3J19D@40117|Nitrospirae 40117|Nitrospirae O ABC transporter - - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_267889_1 187272.Mlg_0342 4.28e-99 296.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1519333_1 436308.Nmar_1320 1.03e-132 399.0 COG1205@1|root,arCOG00555@2157|Archaea,41SZS@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD DEAH box helicase - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C k59_320564_1 1459636.NTE_00592 2.24e-34 129.0 COG2514@1|root,arCOG06106@2157|Archaea 2157|Archaea S Glyoxalase bleomycin resistance protein dioxygenase - - 1.13.11.2 ko:K07104 ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220 M00569 R00816,R04089,R05295,R05404,R05406,R07795 RC00387,RC00643,RC01075,RC01364,RC01914 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase k59_215425_1 436229.JOEH01000002_gene3328 1.34e-38 134.0 COG2606@1|root,COG2606@2|Bacteria,2IHS8@201174|Actinobacteria,2NI5Q@228398|Streptacidiphilus 201174|Actinobacteria S Aminoacyl-tRNA editing domain ybaK - - ko:K03976 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_215425_2 483219.LILAB_30740 2.35e-25 99.4 COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,430Y1@68525|delta/epsilon subdivisions,2WVU4@28221|Deltaproteobacteria,2YVFD@29|Myxococcales 28221|Deltaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20 k59_215425_3 266117.Rxyl_2004 6.51e-24 101.0 COG0126@1|root,COG0126@2|Bacteria,2GJC6@201174|Actinobacteria,4CPN6@84995|Rubrobacteria 84995|Rubrobacteria F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_791696_1 261292.Nit79A3_3205 6.19e-18 81.6 COG3219@1|root,COG3219@2|Bacteria,1R8C9@1224|Proteobacteria,2VPVN@28216|Betaproteobacteria,372NA@32003|Nitrosomonadales 28216|Betaproteobacteria S Putative DNA-binding domain - - - ko:K09929 - - - - ko00000 - - - DUF2063 k59_791696_2 1411685.U062_00409 7.17e-96 287.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria,1J4P3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_791700_1 1183438.GKIL_2604 1.16e-21 92.4 COG2095@1|root,COG2095@2|Bacteria,1G316@1117|Cyanobacteria 1117|Cyanobacteria U PFAM MarC family integral membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_1051537_1 857087.Metme_2760 1.74e-21 95.5 COG0421@1|root,COG0421@2|Bacteria,1N1PJ@1224|Proteobacteria,1T2R5@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - - k59_1470052_1 1123257.AUFV01000009_gene2171 7.51e-26 108.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RM88@1236|Gammaproteobacteria,1X4PF@135614|Xanthomonadales 135614|Xanthomonadales I fatty acid desaturase desC - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_842445_1 243275.TDE_1049 9.44e-76 247.0 COG0480@1|root,COG0480@2|Bacteria,2J5M8@203691|Spirochaetes 203691|Spirochaetes J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_894885_1 1265310.CCBD010000064_gene1074 6.47e-112 338.0 COG2124@1|root,COG2124@2|Bacteria,2HSPE@201174|Actinobacteria,2353U@1762|Mycobacteriaceae 201174|Actinobacteria Q cytochrome P-450 - - - - - - - - - - - - p450 k59_1470060_2 518766.Rmar_1973 9.05e-106 315.0 COG1878@1|root,COG1878@2|Bacteria,4PIWM@976|Bacteroidetes,1FJPB@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Putative cyclase - GO:0003674,GO:0003824,GO:0004061,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.9 ko:K07130 ko00380,ko00630,ko01100,map00380,map00630,map01100 M00038 R00988,R01959,R04911 RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Cyclase k59_1519346_1 563040.Saut_1499 1.27e-13 70.1 COG4641@1|root,COG4641@2|Bacteria,1R64N@1224|Proteobacteria,42N73@68525|delta/epsilon subdivisions 1224|Proteobacteria S DUF based on E. rectale Gene description (DUF3880) - - - ko:K06320 - - - - ko00000 - - - DUF3880,Glyco_trans_1_2 k59_1519346_2 1123514.KB905899_gene1665 1.3e-115 341.0 COG0457@1|root,COG0457@2|Bacteria,1RB9H@1224|Proteobacteria,1SMBV@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Glycosyltransferase family 10 (fucosyltransferase) C-term - - - - - - - - - - - - Glyco_transf_10 k59_1261950_2 670487.Ocepr_1528 3.04e-06 53.1 COG4586@1|root,COG4586@2|Bacteria,1WJ1U@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S transport system ATPase component - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_60596_1 748247.AZKH_1058 9.1e-85 260.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2VJD7@28216|Betaproteobacteria,2KVIA@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_842464_2 1121121.KB894326_gene3056 1.59e-19 96.3 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,4HAFP@91061|Bacilli,26SD1@186822|Paenibacillaceae 91061|Bacilli V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrB1 - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_110589_1 469381.Dpep_1897 1.71e-37 144.0 COG0358@1|root,COG0358@2|Bacteria,3TAFM@508458|Synergistetes 508458|Synergistetes L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_110589_2 443255.SCLAV_2575 1.18e-13 68.9 COG1610@1|root,COG1610@2|Bacteria,2IFFJ@201174|Actinobacteria 201174|Actinobacteria S GatB YqeY yqeY - - ko:K09117 - - - - ko00000 - - - YqeY k59_372247_1 754477.Q7C_160 4.29e-36 134.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,45ZS4@72273|Thiotrichales 72273|Thiotrichales S Succinylglutamate desuccinylase aspartoacylase - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_372247_2 713586.KB900536_gene925 1.72e-14 72.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1WWI6@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_1519352_1 1121405.dsmv_2119 1.41e-62 213.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MIDR@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-3 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_60601_1 223926.28808106 1.59e-281 787.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1XT9G@135623|Vibrionales 135623|Vibrionales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_3372_1 1380394.JADL01000011_gene3977 1.72e-40 152.0 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,2JR1W@204441|Rhodospirillales 204441|Rhodospirillales E 2Fe-2S iron-sulfur cluster binding domain - - 1.5.99.5 ko:K22086 ko00680,ko01120,map00680,map01120 - R00609 RC00190,RC00557 ko00000,ko00001,ko01000 - - - FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2 k59_1573270_1 1110502.TMO_1599 6.09e-56 183.0 28NA5@1|root,2ZBDZ@2|Bacteria,1MXY5@1224|Proteobacteria,2TYZX@28211|Alphaproteobacteria,2JWJ4@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_110599_1 935567.JAES01000016_gene1488 3.99e-10 65.5 COG0702@1|root,COG0702@2|Bacteria,1MZ0C@1224|Proteobacteria,1S2PQ@1236|Gammaproteobacteria,1XC7P@135614|Xanthomonadales 135614|Xanthomonadales GM DoxX-like family - - - - - - - - - - - - DoxX_3,NAD_binding_10 k59_842489_1 713586.KB900536_gene1247 2.27e-103 324.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales 135613|Chromatiales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_60618_1 349521.HCH_05412 3.09e-13 74.7 2E2S0@1|root,32XUC@2|Bacteria,1N3J9@1224|Proteobacteria,1SEDM@1236|Gammaproteobacteria,1XQAY@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_1051586_1 1444309.JAQG01000087_gene2646 3.37e-103 319.0 COG2124@1|root,COG2124@2|Bacteria,1TSC5@1239|Firmicutes,4HBG5@91061|Bacilli,272TG@186822|Paenibacillaceae 91061|Bacilli Q Cytochrome P450 - - - - - - - - - - - - p450 k59_215494_1 1528106.JRJE01000009_gene1755 1.01e-96 295.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,2JQ2W@204441|Rhodospirillales 204441|Rhodospirillales H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_215496_1 399739.Pmen_4121 9.6e-36 126.0 COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,1T1K1@1236|Gammaproteobacteria,1YJHF@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Domain in cystathionine beta-synthase and other proteins. hrp1 - - - - - - - - - - - CBS k59_1261990_2 391615.ABSJ01000037_gene898 1.75e-08 54.3 2EQ5T@1|root,32ZV0@2|Bacteria,1NFTI@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1261990_3 1318628.MARLIPOL_04550 5.44e-05 46.2 COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,1RRWP@1236|Gammaproteobacteria,465RQ@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG0811 Biopolymer transport proteins - - - - - - - - - - - - MotA_ExbB k59_1209916_1 381666.H16_B0948 9.76e-39 146.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2VIEA@28216|Betaproteobacteria,1KFF9@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family nirB - 1.18.1.1,1.7.1.15 ko:K00362,ko:K05297 ko00071,ko00910,ko01120,map00071,map00910,map01120 M00530 R00787,R02000 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_1470109_2 1408445.JHXP01000009_gene2817 1.48e-09 58.9 COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1JD0B@118969|Legionellales 118969|Legionellales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPB GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_791774_1 1301098.PKB_4241 1.6e-21 90.9 COG1028@1|root,COG1028@2|Bacteria,1P1U4@1224|Proteobacteria,1RR3M@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_791774_2 196162.Noca_2009 2.75e-105 320.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DP24@85009|Propionibacteriales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1051592_1 1123322.KB904680_gene3282 7.49e-49 167.0 COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_946388_2 396588.Tgr7_2510 7.5e-44 149.0 2CBRD@1|root,32RTX@2|Bacteria,1R5XB@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_946388_3 570967.JMLV01000001_gene2583 1.6e-12 65.5 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,2JQ2Y@204441|Rhodospirillales 204441|Rhodospirillales T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_1519364_1 1168065.DOK_15074 1.82e-105 323.0 COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,1RN53@1236|Gammaproteobacteria,1J4US@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the aldehyde dehydrogenase family calB - 1.2.1.68 ko:K00154 - - - - ko00000,ko01000 - - - Aldedh k59_1312394_1 1122247.C731_1145 7.74e-21 96.7 COG4191@1|root,COG4191@2|Bacteria,2GMRD@201174|Actinobacteria,232WA@1762|Mycobacteriaceae 201174|Actinobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,cNMP_binding k59_1103837_1 765420.OSCT_0648 8.79e-33 130.0 COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,2GBI2@200795|Chloroflexi,376CQ@32061|Chloroflexia 32061|Chloroflexia T ATP-binding region, ATPase domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Response_reg k59_737875_1 247490.KSU1_C1324 4.16e-49 177.0 COG1957@1|root,COG3055@1|root,COG3204@1|root,COG4932@1|root,COG1957@2|Bacteria,COG3055@2|Bacteria,COG3204@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - - ko:K02674,ko:K07004 - - - - ko00000,ko02035,ko02044 - - - DUF547,Laminin_G_3,Malectin k59_946392_1 1249627.D779_0060 3.61e-08 57.4 COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1WW9X@135613|Chromatiales 135613|Chromatiales M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_946392_2 95619.PM1_0204900 5.24e-22 96.3 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S11 family dacA GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - iEC55989_1330.EC55989_2269,iSFV_1184.SFV_0694,iSbBS512_1146.SbBS512_E2506,iYL1228.KPN_00664 PBP5_C,Peptidase_S11 k59_1268720_2 1123073.KB899242_gene1222 7.78e-13 67.8 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1X4CK@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the sigma-70 factor family. ECF subfamily rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_377814_3 1122164.JHWF01000053_gene1416 1.22e-12 67.8 COG0780@1|root,COG0780@2|Bacteria 2|Bacteria G Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF k59_166505_1 330214.NIDE0823 8.06e-83 252.0 COG1013@1|root,COG1013@2|Bacteria,3J10F@40117|Nitrospirae 2|Bacteria C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism forB2 - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_1268732_1 1122165.AUHS01000028_gene1793 4.52e-55 187.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,1JCEU@118969|Legionellales 118969|Legionellales I Thiolase, C-terminal domain - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_642023_1 305700.B447_09323 1.11e-32 130.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2VJ61@28216|Betaproteobacteria 28216|Betaproteobacteria S of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_642023_2 757424.Hsero_3941 1.19e-20 93.2 28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,2VJJ3@28216|Betaproteobacteria,474C9@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_951647_1 435591.BDI_3207 6.74e-29 120.0 COG0535@1|root,COG0535@2|Bacteria,4PA9R@976|Bacteroidetes,2FWDR@200643|Bacteroidia 976|Bacteroidetes S Radical SAM superfamily - - - - - - - - - - - - Fer4_14,Radical_SAM k59_799016_1 1117958.PE143B_0125995 8.14e-09 55.1 COG3636@1|root,COG3636@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - HTH_26,HTH_3 k59_325987_1 215803.DB30_7489 2.76e-72 246.0 COG1858@1|root,COG2706@1|root,COG3391@1|root,COG1858@2|Bacteria,COG2706@2|Bacteria,COG3391@2|Bacteria,1R66T@1224|Proteobacteria,438GV@68525|delta/epsilon subdivisions,2X3RP@28221|Deltaproteobacteria,2YWY2@29|Myxococcales 28221|Deltaproteobacteria P cytochrome C peroxidase - - - - - - - - - - - - - k59_1423251_1 589865.DaAHT2_0631 3.12e-20 89.4 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42N78@68525|delta/epsilon subdivisions,2WM0M@28221|Deltaproteobacteria,2MHVS@213118|Desulfobacterales 28221|Deltaproteobacteria M Mechanosensitive ion channel mscS-2 - - - - - - - - - - - MS_channel k59_847708_1 765910.MARPU_01140 5.09e-41 154.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales 135613|Chromatiales OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1004000_1 1211815.CBYP010000073_gene3659 5.67e-21 95.1 COG4427@1|root,COG4427@2|Bacteria,2HVQW@201174|Actinobacteria,4EVQ9@85013|Frankiales 201174|Actinobacteria S Uncharacterized protein conserved in bacteria (DUF2332) - - - - - - - - - - - - DUF2332 k59_273250_1 690597.JH730982_gene1986 1.89e-46 159.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RS1R@1236|Gammaproteobacteria,1YP1X@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria P ABC transporter permease - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_273250_2 1288298.rosmuc_02806 1.54e-12 67.0 COG0747@1|root,COG0747@2|Bacteria,1MUPE@1224|Proteobacteria,2TS4U@28211|Alphaproteobacteria,46NGP@74030|Roseovarius 28211|Alphaproteobacteria E COG0747 ABC-type dipeptide transport system, periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_692799_1 909663.KI867149_gene3370 1.42e-104 327.0 COG1075@1|root,COG1075@2|Bacteria,1NYAK@1224|Proteobacteria,42Q3C@68525|delta/epsilon subdivisions,2WMAK@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_6 k59_847713_1 436308.Nmar_1243 1.08e-89 276.0 COG0433@1|root,arCOG00280@2157|Archaea,41SE3@651137|Thaumarchaeota 651137|Thaumarchaeota L Domain of unknown function DUF87 - - - ko:K06915 - - - - ko00000 - - - DUF87 k59_847713_2 436308.Nmar_1244 9.67e-31 117.0 COG0420@1|root,arCOG00397@2157|Archaea,41S68@651137|Thaumarchaeota 651137|Thaumarchaeota L Calcineurin-like phosphoesterase superfamily domain - - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos_2 k59_115729_2 1408473.JHXO01000008_gene2746 1.07e-11 66.2 COG1252@1|root,COG1252@2|Bacteria,4NE0H@976|Bacteroidetes,2FNZW@200643|Bacteroidia 976|Bacteroidetes C Pyridine nucleotide-disulfide oxidoreductase ndh - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_5389_1 986075.CathTA2_1436 9.33e-36 132.0 COG1960@1|root,COG1960@2|Bacteria,1UK89@1239|Firmicutes,4HAR5@91061|Bacilli 91061|Bacilli I acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_5389_2 882083.SacmaDRAFT_5654 1.12e-148 424.0 COG1024@1|root,COG1024@2|Bacteria,2GN3P@201174|Actinobacteria,4E5P5@85010|Pseudonocardiales 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_5389_3 264462.Bd1201 6.35e-41 146.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42M0R@68525|delta/epsilon subdivisions,2MSUE@213481|Bdellovibrionales,2WJE6@28221|Deltaproteobacteria 213481|Bdellovibrionales C PFAM acyl-CoA dehydrogenase domain protein - - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_67456_1 1260251.SPISAL_01180 1.7e-60 218.0 COG0475@1|root,COG1226@1|root,COG3273@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,COG3273@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1WX9W@135613|Chromatiales 135613|Chromatiales P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_847722_1 765914.ThisiDRAFT_0180 8.69e-80 253.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales 135613|Chromatiales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_1317059_1 631362.Thi970DRAFT_02288 5.79e-63 209.0 COG4146@1|root,COG4146@2|Bacteria,1MXWV@1224|Proteobacteria,1RR4S@1236|Gammaproteobacteria,1X0HX@135613|Chromatiales 135613|Chromatiales S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_273263_1 1209072.ALBT01000034_gene1783 1.11e-90 279.0 COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria,1FGKN@10|Cellvibrio 1236|Gammaproteobacteria S Domain of unknown function (DUF4478) ygdH GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016798,GO:0016799,GO:0044424,GO:0044444,GO:0044464,GO:0047405 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - DUF3412,DUF4478,Lysine_decarbox k59_1160323_1 293826.Amet_0687 2.87e-45 162.0 COG0074@1|root,COG0074@2|Bacteria,1UJ4F@1239|Firmicutes,24AQG@186801|Clostridia,36E6R@31979|Clostridiaceae 186801|Clostridia C CoA-ligase - - - ko:K02381 - - - - ko00000 - - - CoA_binding,DUF1116,Ligase_CoA k59_1160323_2 439481.Aboo_0039 2.42e-103 311.0 COG0549@1|root,arCOG00863@2157|Archaea,2XTCB@28890|Euryarchaeota,3F2X1@33867|unclassified Euryarchaeota 28890|Euryarchaeota E Amino acid kinase family cpkA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase k59_1160323_3 756499.Desde_0772 5.16e-125 364.0 COG2159@1|root,COG2159@2|Bacteria,1UYN5@1239|Firmicutes 1239|Firmicutes S metal-dependent hydrolase of the TIM-barrel fold - - - - - - - - - - - - Amidohydro_2 k59_1160323_4 1122207.MUS1_05715 2.09e-10 59.7 COG2044@1|root,COG2044@2|Bacteria,1MXBQ@1224|Proteobacteria,1S2JG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM DsrE DsrF-like family - - - - - - - - - - - - DrsE k59_483105_2 395493.BegalDRAFT_3062 8.82e-08 55.1 COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,1RZIZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU pilus assembly protein PilW pilW - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_5402_1 1116472.MGMO_116c00180 5.33e-28 118.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XESV@135618|Methylococcales 135618|Methylococcales T Diguanylate cyclase - - - - - - - - - - - - CHASE8,EAL,GGDEF,PAS,PAS_3,Response_reg k59_115750_1 1283300.ATXB01000001_gene577 4.39e-32 134.0 COG1657@1|root,COG2304@1|root,COG3386@1|root,COG1657@2|Bacteria,COG2304@2|Bacteria,COG3386@2|Bacteria,1RFDH@1224|Proteobacteria,1S0SI@1236|Gammaproteobacteria 1236|Gammaproteobacteria H PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - CarboxypepD_reg,DUF1194,Prenyltrans k59_1160328_1 589865.DaAHT2_0798 1.34e-31 122.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,42M7V@68525|delta/epsilon subdivisions,2WIUB@28221|Deltaproteobacteria,2MIV4@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_743025_1 1205753.A989_18025 1.11e-19 93.2 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1X3AY@135614|Xanthomonadales 135614|Xanthomonadales T Chemotaxis protein histidine kinase and related kinases pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_586522_1 1242864.D187_008398 1.64e-52 186.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2YUEA@29|Myxococcales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_273281_1 870187.Thini_2694 1.52e-22 95.1 COG2972@1|root,COG2972@2|Bacteria,1QYRK@1224|Proteobacteria,1T5CC@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365,HAMP k59_273281_2 870187.Thini_2693 3.83e-20 86.3 2ES2F@1|root,33JMD@2|Bacteria,1NQFF@1224|Proteobacteria,1SJHV@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_67484_1 565045.NOR51B_2940 1.54e-29 117.0 COG0520@1|root,COG0520@2|Bacteria,1QU0N@1224|Proteobacteria,1T2JK@1236|Gammaproteobacteria,1JBVM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Aminotransferase class-V kynU - 3.7.1.3 ko:K01556 ko00380,ko01100,map00380,map01100 M00038 R00987,R02668,R03936 RC00284,RC00415 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 k59_5406_1 1038859.AXAU01000002_gene392 2.4e-145 430.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2TRZC@28211|Alphaproteobacteria,3JTXA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Putative nucleotidyltransferase substrate binding domain - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_5406_2 395493.BegalDRAFT_2338 3.18e-61 213.0 COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_7,Response_reg k59_743035_1 595460.RRSWK_04871 1.07e-48 167.0 COG2876@1|root,COG2876@2|Bacteria,2IWU9@203682|Planctomycetes 203682|Planctomycetes E phospho-2-dehydro-3-deoxyheptonate aldolase - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_847743_1 1265503.KB905164_gene1983 3.19e-41 155.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q6IX@267889|Colwelliaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_483133_1 1249627.D779_2643 7.97e-52 188.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - - - - - - - - - - CheW,HATPase_c,Hpt,Response_reg k59_586529_1 331869.BAL199_04764 1.05e-96 309.0 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,4BPQ6@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the GcvT family soxA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.5.3.1 ko:K00302 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2 k59_586529_2 1449976.KALB_3163 2.3e-44 145.0 COG4311@1|root,COG4311@2|Bacteria,2IQIZ@201174|Actinobacteria,4E5CD@85010|Pseudonocardiales 201174|Actinobacteria E Sarcosine oxidase, delta subunit family soxD - 1.5.3.1 ko:K00304 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - SoxD k59_1423306_1 32049.SYNPCC7002_A0052 9.58e-27 103.0 COG0511@1|root,COG0511@2|Bacteria,1G6MY@1117|Cyanobacteria,1GZ7K@1129|Synechococcus 1117|Cyanobacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl k59_1423306_2 160492.XF_0049 2.04e-21 92.4 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1X43Q@135614|Xanthomonadales 135614|Xanthomonadales I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_586530_1 2340.JV46_17590 2.93e-21 90.5 2BE3G@1|root,327U6@2|Bacteria,1RI7X@1224|Proteobacteria,1S88B@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1268813_2 742735.HMPREF9467_00865 9.28e-34 120.0 COG0758@1|root,COG0758@2|Bacteria,1VNFT@1239|Firmicutes 1239|Firmicutes LU Protein of unknown function (DUF2493) - - - - - - - - - - - - DUF2493 k59_1268813_3 1162305.I3PV34_9CAUD 1.12e-09 56.2 4QAZF@10239|Viruses,4QUTY@35237|dsDNA viruses no RNA stage,4QPH6@28883|Caudovirales,4QNEM@10744|Podoviridae 10744|Podoviridae S Protein of unknwon function (DUF3310) - - - - - - - - - - - - - k59_642108_1 1033743.CAES01000035_gene1288 2.05e-23 102.0 COG1028@1|root,COG1028@2|Bacteria,1TRQB@1239|Firmicutes,4HAY3@91061|Bacilli,26QR4@186822|Paenibacillaceae 91061|Bacilli IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1476848_1 1123367.C666_02930 7.25e-101 306.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2VJ2E@28216|Betaproteobacteria,2KVBW@206389|Rhodocyclales 206389|Rhodocyclales K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_377904_1 1493512.A0A0E3HG50_9CAUD 1.75e-25 109.0 4QAZ6@10239|Viruses,4QPHV@28883|Caudovirales,4QI4H@10662|Myoviridae 10662|Myoviridae S Phage tail sheath protein - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098027 - - - - - - - - - - - k59_166583_1 570967.JMLV01000001_gene2824 2.34e-68 223.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,2JPM5@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the binding-protein-dependent transport system permease family livM - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2,DUF3382 k59_534100_1 1283300.ATXB01000002_gene2668 3.55e-93 290.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1XE3D@135618|Methylococcales 1236|Gammaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_692884_1 1207063.P24_14949 1.55e-96 295.0 COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,2TSSE@28211|Alphaproteobacteria,2JPVC@204441|Rhodospirillales 204441|Rhodospirillales G Malonyl-CoA decarboxylase N-terminal domain - - - - - - - - - - - - MCD,MCD_N k59_1268828_1 1229909.NSED_00110 2.52e-13 68.9 COG1903@1|root,arCOG04383@2157|Archaea,41S70@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A cbiD - 2.1.1.195 ko:K02188 ko00860,ko01100,map00860,map01100 - R07773 RC00003,RC02051 ko00000,ko00001,ko01000 - - - CbiD k59_1268828_2 436308.Nmar_0082 4.25e-80 247.0 COG2073@1|root,arCOG00651@2157|Archaea,41S83@651137|Thaumarchaeota 651137|Thaumarchaeota H Cobalamin synthesis G C-terminus - - 3.7.1.12 ko:K02189 ko00860,ko01100,map00860,map01100 - R07772 RC01545,RC02097 ko00000,ko00001,ko01000 - - - CbiG_C,CbiG_N,CbiG_mid k59_5426_1 1082933.MEA186_04556 4.61e-48 176.0 COG2911@1|root,COG3204@1|root,COG2911@2|Bacteria,COG3204@2|Bacteria 2|Bacteria L pilus organization - - - ko:K02674,ko:K07004 - - - - ko00000,ko02035,ko02044 - - - Cadherin,Exo_endo_phos,HemolysinCabind,LTD,Laminin_G_3,SNase k59_273302_1 112098.XP_008610615.1 1.06e-09 70.1 COG0631@1|root,COG0664@1|root,KOG0585@1|root,KOG0585@2759|Eukaryota,KOG0698@2759|Eukaryota,KOG1113@2759|Eukaryota 2759|Eukaryota T cAMP-dependent protein kinase regulator activity spnA GO:0000166,GO:0000287,GO:0001101,GO:0001726,GO:0001882,GO:0001883,GO:0002682,GO:0002697,GO:0002831,GO:0003674,GO:0003824,GO:0004721,GO:0004722,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009414,GO:0009415,GO:0009628,GO:0009651,GO:0009653,GO:0009719,GO:0009725,GO:0009737,GO:0009889,GO:0009987,GO:0010033,GO:0010035,GO:0010468,GO:0010556,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0019001,GO:0019219,GO:0019222,GO:0019538,GO:0030145,GO:0030154,GO:0031252,GO:0031323,GO:0031326,GO:0031347,GO:0032101,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033554,GO:0033993,GO:0035639,GO:0036094,GO:0036211,GO:0042221,GO:0042578,GO:0042995,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043618,GO:0043620,GO:0043900,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048583,GO:0048856,GO:0048869,GO:0050688,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061392,GO:0061416,GO:0065007,GO:0071214,GO:0071470,GO:0071472,GO:0071704,GO:0080090,GO:0080134,GO:0097159,GO:0097305,GO:0097367,GO:0104004,GO:0120025,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901700,GO:1903506,GO:2000112,GO:2001141 2.7.11.17,3.1.3.16 ko:K01090,ko:K04739,ko:K07359,ko:K14803,ko:K17500 ko04140,ko04152,ko04211,ko04910,ko04920,ko04921,ko05034,map04140,map04152,map04211,map04910,map04920,map04921,map05034 - - - ko00000,ko00001,ko01000,ko01001,ko01009,ko03009 - - - PP2C,Pkinase,cNMP_binding k59_1370047_1 272624.lpg1713 1.2e-60 197.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1JCZR@118969|Legionellales 118969|Legionellales J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_326069_1 926549.KI421517_gene3224 1.39e-198 572.0 COG2225@1|root,COG2225@2|Bacteria,4NF5H@976|Bacteroidetes,47JKU@768503|Cytophagia 976|Bacteroidetes C Malate synthase - - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_1423341_2 436308.Nmar_1124 1.47e-86 262.0 COG0074@1|root,arCOG01339@2157|Archaea,41SEU@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_847775_1 1265505.ATUG01000001_gene3288 7.96e-36 138.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,2MHY5@213118|Desulfobacterales 28221|Deltaproteobacteria G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_1578584_1 1121937.AUHJ01000041_gene279 5.3e-52 174.0 COG0451@1|root,COG0451@2|Bacteria,1RGHF@1224|Proteobacteria,1RQTC@1236|Gammaproteobacteria,4696K@72275|Alteromonadaceae 1236|Gammaproteobacteria GM GDP-mannose 4,6 dehydratase - - - - - - - - - - - - Epimerase k59_693690_1 716928.AJQT01000109_gene1217 6.27e-30 110.0 2FEUE@1|root,346TC@2|Bacteria,1MZPB@1224|Proteobacteria,2UC4Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_167458_1 1163409.UUA_08366 3.41e-29 118.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,1X3Y7@135614|Xanthomonadales 135614|Xanthomonadales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1321838_1 1128427.KB904821_gene4605 2.57e-28 116.0 COG0367@1|root,COG0367@2|Bacteria,1G3S7@1117|Cyanobacteria,1H8UK@1150|Oscillatoriales 1117|Cyanobacteria E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1485349_1 1033802.SSPSH_003111 1.1e-98 320.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_749521_1 349124.Hhal_0053 2.48e-19 88.6 COG0247@1|root,COG0277@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG0479@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales 135613|Chromatiales C FAD linked - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_749521_2 85643.Tmz1t_0690 6.19e-26 107.0 COG0247@1|root,COG0277@1|root,COG1145@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG1145@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,2KUWB@206389|Rhodocyclales 206389|Rhodocyclales C FAD linked oxidase - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_1223091_2 717773.Thicy_0584 1.33e-41 147.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,45ZZZ@72273|Thiotrichales 72273|Thiotrichales C Part of a membrane complex involved in electron transport - - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_540388_1 1042876.PPS_2937 1.28e-51 179.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1YYF6@136845|Pseudomonas putida group 1236|Gammaproteobacteria IQ PFAM AMP-dependent synthetase and ligase yngI - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_807784_1 252305.OB2597_12081 1.87e-12 67.8 COG0515@1|root,COG0515@2|Bacteria,1QVSB@1224|Proteobacteria,2TWKG@28211|Alphaproteobacteria 28211|Alphaproteobacteria KLT serine threonine protein kinase - - - - - - - - - - - - - k59_1277650_1 314231.FP2506_00900 3.12e-60 194.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria,2PJGF@255475|Aurantimonadaceae 28211|Alphaproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit - - - - - - - - - - - - CoA_binding,Ligase_CoA k59_1277650_2 1041146.ATZB01000009_gene3565 7.61e-06 47.4 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TSM8@28211|Alphaproteobacteria,4B80B@82115|Rhizobiaceae 28211|Alphaproteobacteria CH D-isomer specific 2-hydroxyacid dehydrogenase gyaR2 - 1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81 ko:K00015,ko:K00050,ko:K00090 ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120 - R00465,R00717,R01388,R01392,R01739 RC00031,RC00042,RC00084 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_650689_1 1278078.G419_13101 9.73e-44 153.0 COG1028@1|root,COG1028@2|Bacteria,2GKI2@201174|Actinobacteria,4FYFT@85025|Nocardiaceae 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short,adh_short_C2 k59_650690_1 444860.E3SJ27_9CAUD 1.55e-159 472.0 4QERI@10239|Viruses,4QYA1@35237|dsDNA viruses no RNA stage,4QS5A@28883|Caudovirales,4QIAY@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_592953_1 1121937.AUHJ01000009_gene1566 8.04e-72 219.0 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,468KZ@72275|Alteromonadaceae 1236|Gammaproteobacteria M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL k59_1223102_1 472759.Nhal_2172 3.13e-08 57.0 COG0300@1|root,COG0300@2|Bacteria,1NGXF@1224|Proteobacteria,1S25V@1236|Gammaproteobacteria,1WZZS@135613|Chromatiales 135613|Chromatiales S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_1223102_2 1203190.CAJP01000015_gene973 2.44e-20 94.4 COG0277@1|root,COG0277@2|Bacteria,2I2AB@201174|Actinobacteria,22K4Y@1653|Corynebacteriaceae 201174|Actinobacteria C FAD FMN-containing dehydrogenases dprE1 - 1.1.98.3 ko:K16653 - - - - ko00000,ko01000 - - - ALO,FAD_binding_4 k59_1376352_1 1123229.AUBC01000005_gene759 3.01e-16 82.0 COG1018@1|root,COG1600@1|root,COG1018@2|Bacteria,COG1600@2|Bacteria,1MU6E@1224|Proteobacteria,2TRE9@28211|Alphaproteobacteria,3JSXZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain vanB - - ko:K03863 ko00627,ko01120,map00627,map01120 - R05274 RC00392,RC01533 ko00000,ko00001 - - - Dehalogenase,FAD_binding_6,Fer2,Fer4_16,Fer4_7,NAD_binding_1 k59_172540_1 330214.NIDE0243 1.32e-50 168.0 COG0560@1|root,COG0560@2|Bacteria 2|Bacteria E Phosphoserine phosphatase - - - - - - - - - - - - HAD,NAD_binding_4,Sterile k59_124237_1 1095772.CAHH01000039_gene990 4.06e-35 139.0 COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria 201174|Actinobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_124237_2 596151.DesfrDRAFT_2256 7.69e-51 177.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,42MAP@68525|delta/epsilon subdivisions,2WIYI@28221|Deltaproteobacteria,2M8GG@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM Sodium sulphate symporter sdcS - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_1223110_1 258594.RPA1708 1.06e-49 170.0 COG1960@1|root,COG1960@2|Bacteria,1N05C@1224|Proteobacteria,2TT9T@28211|Alphaproteobacteria,3JTG7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I acyl-CoA dehydrogenase MA20_06725 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_650701_2 56780.SYN_01599 6.3e-58 182.0 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,42R43@68525|delta/epsilon subdivisions,2WPH1@28221|Deltaproteobacteria,2MQGH@213462|Syntrophobacterales 28221|Deltaproteobacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_1585215_1 187272.Mlg_2833 1.6e-81 250.0 COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,1RMS7@1236|Gammaproteobacteria,1WWCG@135613|Chromatiales 135613|Chromatiales C PFAM Phosphoribulokinase uridine kinase - - 2.7.1.19 ko:K00855 ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200 M00165,M00166 R01523 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PRK k59_1585215_2 1123392.AQWL01000006_gene744 1.83e-06 49.7 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,1KSNF@119069|Hydrogenophilales 119069|Hydrogenophilales V ABC transporter transmembrane region - - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_491782_1 1185766.DL1_08630 6.84e-25 109.0 COG0175@1|root,COG0175@2|Bacteria 2|Bacteria EH sulfate reduction - - - - - - - - - - - - PAPS_reduct k59_76059_1 1123508.JH636439_gene1359 3.76e-19 87.8 COG1561@1|root,COG1561@2|Bacteria,2IYZH@203682|Planctomycetes 203682|Planctomycetes S stress-induced protein - - - - - - - - - - - - DUF1732,YicC_N k59_76059_2 690850.Desaf_2118 2.6e-10 57.0 COG2052@1|root,COG2052@2|Bacteria,1N0KP@1224|Proteobacteria,42TSK@68525|delta/epsilon subdivisions,2WQHH@28221|Deltaproteobacteria,2MCH0@213115|Desulfovibrionales 28221|Deltaproteobacteria S Belongs to the UPF0296 family - - - ko:K09777 - - - - ko00000 - - - DUF370 k59_437102_2 330214.NIDE3374 3.21e-43 153.0 28I4Y@1|root,2Z88D@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1165479_1 702113.PP1Y_Mpl2874 8.4e-32 127.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2U41M@28211|Alphaproteobacteria,2KCNP@204457|Sphingomonadales 204457|Sphingomonadales IQ AMP-dependent synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_592962_1 713586.KB900536_gene2049 8.58e-128 389.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales 135613|Chromatiales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_592962_3 1120999.JONM01000006_gene2497 7.56e-66 206.0 COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,2VQ49@28216|Betaproteobacteria,2KQEH@206351|Neisseriales 206351|Neisseriales E D,D-heptose 1,7-bisphosphate phosphatase gmhB - 3.1.3.82,3.1.3.83 ko:K03273 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_like k59_592962_4 765912.Thimo_3687 3.32e-05 47.8 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1WXP3@135613|Chromatiales 135613|Chromatiales I PFAM Phospholipid glycerol acyltransferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_699471_1 502025.Hoch_1793 5.91e-80 263.0 COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,1MV6M@1224|Proteobacteria,42M5P@68525|delta/epsilon subdivisions,2WIW8@28221|Deltaproteobacteria,2YUB7@29|Myxococcales 28221|Deltaproteobacteria KL Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_76081_1 1190606.AJYG01000074_gene170 1.16e-101 311.0 COG1178@1|root,COG1178@2|Bacteria,1MXZZ@1224|Proteobacteria,1RY3W@1236|Gammaproteobacteria,1XTGS@135623|Vibrionales 135623|Vibrionales P ABC-type Fe3 transport system, permease component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_1223135_2 1122599.AUGR01000001_gene461 0.00062 43.5 COG3584@1|root,COG3584@2|Bacteria,1MZPJ@1224|Proteobacteria,1SBH0@1236|Gammaproteobacteria,1XQAG@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - - - - - - - - - - - k59_1638364_1 90813.JQMT01000001_gene1095 8.67e-54 178.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,460B4@72273|Thiotrichales 72273|Thiotrichales O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_1485423_1 1236959.BAMT01000002_gene2310 1.29e-35 127.0 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2VJQA@28216|Betaproteobacteria,2KMR8@206350|Nitrosomonadales 206350|Nitrosomonadales K Belongs to the UPF0301 (AlgH) family - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_1485423_2 1117647.M5M_11280 4.12e-21 87.4 COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria,1J6MD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yqgF GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_1431778_1 760011.Spico_0376 6.16e-73 234.0 COG2270@1|root,COG2270@2|Bacteria,2J9X6@203691|Spirochaetes 203691|Spirochaetes S Vacuole effluxer Atg22 like - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_1585249_1 765910.MARPU_10885 5.05e-61 194.0 COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,1RYZ2@1236|Gammaproteobacteria,1WW9H@135613|Chromatiales 135613|Chromatiales C PFAM Nitrate reductase gamma subunit - - - - - - - - - - - - Nitrate_red_gam k59_386596_1 768671.ThimaDRAFT_4548 7.54e-97 291.0 COG1073@1|root,COG1073@2|Bacteria,1R76C@1224|Proteobacteria,1RR34@1236|Gammaproteobacteria,1X0RN@135613|Chromatiales 135613|Chromatiales S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 k59_541173_1 622637.KE124774_gene3542 5.92e-212 598.0 COG3385@1|root,COG3385@2|Bacteria,1QURV@1224|Proteobacteria,2TW56@28211|Alphaproteobacteria,371IT@31993|Methylocystaceae 28211|Alphaproteobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_593787_1 1229780.BN381_360022 4.09e-25 104.0 COG1680@1|root,COG1680@2|Bacteria,2HEWU@201174|Actinobacteria,3UXIA@52018|unclassified Actinobacteria (class) 201174|Actinobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_492852_1 765912.Thimo_2642 3.52e-104 312.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1WWGS@135613|Chromatiales 135613|Chromatiales E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - - ko:K10764 ko00270,ko00920,ko01100,map00270,map00920,map01100 - R01288 RC00020,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_1166047_1 521000.PROVRETT_06666 0.000107 47.4 COG0790@1|root,COG0790@2|Bacteria,1NRKR@1224|Proteobacteria,1SN2R@1236|Gammaproteobacteria,3Z8V5@586|Providencia 1236|Gammaproteobacteria S Psort location Extracellular, score 8.44 - - - - - - - - - - - - Sel1 k59_1064477_1 439235.Dalk_2046 3.3e-44 166.0 COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MIEE@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_1586070_2 1266925.JHVX01000011_gene1448 1.54e-30 117.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VK3J@28216|Betaproteobacteria,3725A@32003|Nitrosomonadales 28216|Betaproteobacteria E PFAM Orn DAP Arg decarboxylase 2 - - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_280872_1 1178482.BJB45_20440 1.27e-139 409.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1XHRG@135619|Oceanospirillales 135619|Oceanospirillales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1064479_1 207954.MED92_18233 3.72e-63 218.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1XISX@135619|Oceanospirillales 135619|Oceanospirillales NU Tfp pilus assembly protein, tip-associated adhesin PilY1 - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_438028_1 870187.Thini_2586 6.86e-73 241.0 COG0515@1|root,COG0631@1|root,COG0515@2|Bacteria,COG0631@2|Bacteria,1MV1P@1224|Proteobacteria,1RNQN@1236|Gammaproteobacteria,4603S@72273|Thiotrichales 72273|Thiotrichales KLT Serine/threonine phosphatases, family 2C, catalytic domain - - - - - - - - - - - - PP2C_2,Pkinase k59_651770_1 366394.Smed_2700 3.34e-38 136.0 COG0561@1|root,COG0561@2|Bacteria,1R4WX@1224|Proteobacteria,2TSDR@28211|Alphaproteobacteria,4B70Y@82115|Rhizobiaceae 28211|Alphaproteobacteria S hydrolases of the HAD superfamily - - - - - - - - - - - - Hydrolase_3 k59_651770_2 1045004.OKIT_0355 3.54e-24 100.0 COG3639@1|root,COG3639@2|Bacteria,1TR1S@1239|Firmicutes,4HBT8@91061|Bacilli,4AWZR@81850|Leuconostocaceae 91061|Bacilli P COG3639 ABC-type phosphate phosphonate transport system, permease component phnB - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 k59_1377095_1 640081.Dsui_1454 1.46e-19 87.8 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,2VQGZ@28216|Betaproteobacteria,2KYI0@206389|Rhodocyclales 206389|Rhodocyclales PT Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese,cNMP_binding k59_1377095_2 395494.Galf_2091 2.94e-23 96.7 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2VHHC@28216|Betaproteobacteria,44V22@713636|Nitrosomonadales 28216|Betaproteobacteria E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004764,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046417,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0055114,GO:0061458,GO:0071704,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_333328_1 1449351.RISW2_04805 2.18e-10 62.4 COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2TT5Y@28211|Alphaproteobacteria,4KMXK@93682|Roseivivax 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter family receptor MA20_43200 - - ko:K07795 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctC k59_333328_2 1089552.KI911559_gene3349 1.78e-54 176.0 2B2JS@1|root,31V51@2|Bacteria,1QT11@1224|Proteobacteria,2VAWF@28211|Alphaproteobacteria,2JY2A@204441|Rhodospirillales 204441|Rhodospirillales S Tripartite tricarboxylate transporter TctB family - - - - - - - - - - - - TctB k59_333328_3 1469245.JFBG01000014_gene2027 1.04e-269 749.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RMQB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tripartite tricarboxylate transporter TctA - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_1278756_1 1121943.KB899990_gene3817 1.32e-15 78.2 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1RYET@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Zn-dependent dipeptidase, microsomal dipeptidase - - - - - - - - - - - - Peptidase_M19 k59_1586076_1 1116472.MGMO_104c00070 2.74e-25 103.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,1RNRG@1236|Gammaproteobacteria 1224|Proteobacteria M PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_4 k59_1486495_1 164757.Mjls_3725 1.87e-50 173.0 COG1018@1|root,COG1018@2|Bacteria,2GKGS@201174|Actinobacteria,235CQ@1762|Mycobacteriaceae 201174|Actinobacteria C COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 - - - - - - - - - - - - FAD_binding_6,Fer2,NAD_binding_1 k59_492915_1 290397.Adeh_2976 4.56e-94 289.0 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,42MN2@68525|delta/epsilon subdivisions,2WIMJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria C cluster binding protein - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_1432830_1 765913.ThidrDRAFT_3644 5.72e-151 439.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1WW8I@135613|Chromatiales 135613|Chromatiales E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_1224041_1 400682.PAC_15703455 2.31e-57 199.0 COG1331@1|root,KOG2244@2759|Eukaryota 2759|Eukaryota O spermatogenesis - - - - - - - - - - - - Glyco_hydro_9,Thioredox_DsbH k59_280902_1 323261.Noc_2673 2.86e-53 174.0 COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1WX5A@135613|Chromatiales 135613|Chromatiales U PFAM MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_280902_2 153948.NAL212_1551 2.53e-11 61.2 COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,2VUF4@28216|Betaproteobacteria,37383@32003|Nitrosomonadales 28216|Betaproteobacteria U Biopolymer transport protein ExbD TolR exbD2 - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_958769_1 247490.KSU1_C1324 4.44e-23 104.0 COG1957@1|root,COG3055@1|root,COG3204@1|root,COG4932@1|root,COG1957@2|Bacteria,COG3055@2|Bacteria,COG3204@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - - ko:K02674,ko:K07004 - - - - ko00000,ko02035,ko02044 - - - DUF547,Laminin_G_3,Malectin k59_492928_1 93220.LV28_18005 2.18e-26 108.0 COG1167@1|root,COG1167@2|Bacteria,1MVGT@1224|Proteobacteria,2VK4P@28216|Betaproteobacteria,1K0ZQ@119060|Burkholderiaceae 28216|Betaproteobacteria K Aminotransferase - - - ko:K00375 - - - - ko00000,ko03000 - - - Aminotran_1_2,GntR k59_651819_1 264462.Bd0975 1.48e-46 160.0 COG0500@1|root,COG2226@2|Bacteria,1QY1T@1224|Proteobacteria,42YBC@68525|delta/epsilon subdivisions,2MSW8@213481|Bdellovibrionales,2WUEA@28221|Deltaproteobacteria 213481|Bdellovibrionales Q methyltransferase - - - - - - - - - - - - - k59_125227_1 985054.JQEZ01000001_gene1831 4.47e-78 240.0 COG1176@1|root,COG1176@2|Bacteria,1MW9Y@1224|Proteobacteria,2TTFC@28211|Alphaproteobacteria,4NA5G@97050|Ruegeria 28211|Alphaproteobacteria P overlaps another CDS with the same product name - - - ko:K11071 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1 k59_125227_2 1177928.TH2_18416 1.79e-24 101.0 COG1177@1|root,COG1177@2|Bacteria,1MWVC@1224|Proteobacteria,2TV8E@28211|Alphaproteobacteria,2JQD9@204441|Rhodospirillales 204441|Rhodospirillales E COG1177 ABC-type spermidine putrescine transport system, permease component II - - - ko:K11070 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1 k59_1432845_2 247490.KSU1_D0131 1.49e-74 242.0 COG4964@1|root,COG4964@2|Bacteria,2IYI6@203682|Planctomycetes 203682|Planctomycetes U Belongs to the GSP D family - - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - Secretin,T2SS-T3SS_pil_N k59_1116439_2 1142394.PSMK_08050 1.07e-12 67.8 COG3046@1|root,COG3046@2|Bacteria,2IY44@203682|Planctomycetes 203682|Planctomycetes S protein related to deoxyribodipyrimidine photolyase - - - ko:K06876 - - - - ko00000 - - - DPRP,FAD_binding_7 k59_178669_1 1384056.N787_12120 1.67e-08 55.8 COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,1S9RP@1236|Gammaproteobacteria,1X6M1@135614|Xanthomonadales 135614|Xanthomonadales S Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division - - - ko:K13053 - - - - ko00000,ko03036 - - - - k59_661226_1 331869.BAL199_29922 1.81e-70 218.0 COG5553@1|root,COG5553@2|Bacteria,1RD6A@1224|Proteobacteria,2U7HF@28211|Alphaproteobacteria,4BT3J@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S metal-dependent enzyme of the double-stranded beta helix superfamily - - - - - - - - - - - - - k59_706947_1 1182590.BN5_00011 8.89e-25 109.0 COG1061@1|root,COG4951@1|root,COG1061@2|Bacteria,COG4951@2|Bacteria,1MV9F@1224|Proteobacteria,1RNAN@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Type III restriction protein res subunit - - - - - - - - - - - - Helicase_C,ResIII k59_287930_1 1115632.JAFW01000001_gene3479 1.4e-27 112.0 COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria 201174|Actinobacteria C alcohol dehydrogenase - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N_2 k59_1592997_3 1297570.MESS4_490008 1.41e-19 94.7 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,43I71@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_1383389_1 1236959.BAMT01000001_gene1483 3.51e-43 152.0 COG1767@1|root,COG1767@2|Bacteria,1RAWI@1224|Proteobacteria,2VQ7E@28216|Betaproteobacteria,2KKD8@206350|Nitrosomonadales 206350|Nitrosomonadales H PFAM triphosphoribosyl-dephospho-CoA protein - - 2.4.2.52 ko:K05966 ko02020,map02020 - R09675 RC00049,RC00063 ko00000,ko00001,ko01000 - - - CitG k59_340234_1 1121374.KB891579_gene1743 5.15e-68 224.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Involved in the processing of the 5'-end of 16S rRNA rng GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_393484_1 595460.RRSWK_02465 6.9e-25 102.0 COG1181@1|root,COG1181@2|Bacteria,2IZEV@203682|Planctomycetes 203682|Planctomycetes F Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C k59_393484_2 56110.Oscil6304_5722 1.92e-33 119.0 COG2331@1|root,COG2331@2|Bacteria 2|Bacteria P Regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 k59_1441985_1 1229909.NSED_07955 2.91e-90 277.0 COG1109@1|root,arCOG00767@2157|Archaea,41SC1@651137|Thaumarchaeota 651137|Thaumarchaeota G phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - - - - - - - - - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1383394_1 1469245.JFBG01000002_gene475 1.16e-81 253.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,1RPRD@1236|Gammaproteobacteria,1X0M2@135613|Chromatiales 135613|Chromatiales C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_1383394_2 65071.PYU1_T005581 1.49e-09 59.7 COG2986@1|root,KOG0222@2759|Eukaryota,1MEMB@121069|Pythiales 121069|Pythiales Q Histidine ammonia-lyase. Source PGD - - - - - - - - - - - - Lyase_aromatic k59_547855_1 338963.Pcar_2032 5.69e-23 99.4 COG0618@1|root,COG0618@2|Bacteria,1N0JS@1224|Proteobacteria,42P1S@68525|delta/epsilon subdivisions,2WJV0@28221|Deltaproteobacteria,43SCM@69541|Desulfuromonadales 28221|Deltaproteobacteria S DHH family - - - - - - - - - - - - DHH,DHHA1 k59_12320_1 485918.Cpin_5451 1.14e-38 131.0 COG2947@1|root,COG2947@2|Bacteria,4NNQG@976|Bacteroidetes,1ISGG@117747|Sphingobacteriia 976|Bacteroidetes S EVE domain - - - - - - - - - - - - EVE k59_12320_2 207559.Dde_1466 5.5e-11 67.4 2E6CS@1|root,3310E@2|Bacteria,1N2FR@1224|Proteobacteria,42UY2@68525|delta/epsilon subdivisions,2WPMU@28221|Deltaproteobacteria,2M8VJ@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_12320_3 370438.PTH_2533 1.13e-36 131.0 COG0106@1|root,COG0106@2|Bacteria,1V1IR@1239|Firmicutes,24GBJ@186801|Clostridia,260RZ@186807|Peptococcaceae 186801|Clostridia E TIGRFAM Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_340242_2 29581.BW37_03999 1.87e-53 189.0 COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,2VMT1@28216|Betaproteobacteria,478K6@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Secretin N-terminal domain exeD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N_2 k59_1172673_2 270374.MELB17_15966 6.38e-44 155.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,464ZZ@72275|Alteromonadaceae 1236|Gammaproteobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - iPC815.YPO3376 Enolase_C,Enolase_N k59_1650519_2 1380355.JNIJ01000045_gene5508 0.000175 43.9 COG0745@1|root,COG0745@2|Bacteria,1RD6H@1224|Proteobacteria,2U7MF@28211|Alphaproteobacteria,3JYXW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_503818_1 1220535.IMCC14465_10910 3.26e-43 157.0 COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,4BRMP@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S MmgE/PrpD family MA20_23745 - - - - - - - - - - - MmgE_PrpD k59_1124728_1 1287276.X752_16915 1.79e-51 174.0 COG0583@1|root,COG0583@2|Bacteria,1PX1B@1224|Proteobacteria,2TUE7@28211|Alphaproteobacteria,43P8R@69277|Phyllobacteriaceae 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_548844_1 671143.DAMO_1702 2.72e-10 63.2 COG1525@1|root,COG1525@2|Bacteria,2NQ3M@2323|unclassified Bacteria 2|Bacteria L Staphylococcal nuclease homologues - - 3.1.31.1 ko:K01174 - - - - ko00000,ko01000 - - - Ada_Zn_binding,SNase k59_341509_1 1123279.ATUS01000001_gene2618 4.16e-48 167.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria,1J4QT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Glycerol-3-phosphate dehydrogenase glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_235896_1 666686.B1NLA3E_02785 1.65e-08 56.2 COG0317@1|root,COG0317@2|Bacteria,1VAH0@1239|Firmicutes,4HIPC@91061|Bacilli,1ZG08@1386|Bacillus 91061|Bacilli KT HD domain - - - - - - - - - - - - HD_4 k59_1072737_1 652103.Rpdx1_0796 5.88e-29 118.0 COG3303@1|root,COG3303@2|Bacteria,1QXZC@1224|Proteobacteria,2TRV1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome c3 - - - - - - - - - - - - Paired_CXXCH_1 k59_1124731_1 335543.Sfum_0987 1.41e-18 80.9 COG0640@1|root,COG0640@2|Bacteria,1RGYC@1224|Proteobacteria,42X86@68525|delta/epsilon subdivisions,2WSJA@28221|Deltaproteobacteria,2MSBA@213462|Syntrophobacterales 28221|Deltaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20,HTH_5 k59_1124731_2 1274524.BSONL12_07177 2.56e-06 49.3 COG0345@1|root,COG0345@2|Bacteria,1TP1E@1239|Firmicutes,4H9RV@91061|Bacilli,1ZCWZ@1386|Bacillus 91061|Bacilli E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_289295_1 330214.NIDE0613 3.09e-134 396.0 COG0649@1|root,COG0852@1|root,COG0649@2|Bacteria,COG0852@2|Bacteria,3J0FM@40117|Nitrospirae 40117|Nitrospirae C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa,NiFeSe_Hases k59_1289773_2 1229909.NSED_09645 1.85e-12 67.8 COG1311@1|root,arCOG04455@2157|Archaea,41T0D@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polB - 2.7.7.7 ko:K02323 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - DNA_pol_E_B k59_819865_1 1232410.KI421428_gene1072 5.27e-43 152.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42S1J@68525|delta/epsilon subdivisions,2WP2S@28221|Deltaproteobacteria,43SI8@69541|Desulfuromonadales 28221|Deltaproteobacteria I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family plsC - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_1329032_1 247490.KSU1_D0138 1.27e-39 143.0 COG2064@1|root,COG2064@2|Bacteria,2IYG1@203682|Planctomycetes 203682|Planctomycetes NU Secretion system protein - - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF k59_1124749_1 1535422.ND16A_0238 6.12e-27 114.0 COG0845@1|root,COG0845@2|Bacteria,1MV1T@1224|Proteobacteria,1RQTS@1236|Gammaproteobacteria,2Q6E9@267889|Colwelliaceae 1236|Gammaproteobacteria M HlyD family secretion protein - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1172700_1 321327.CYA_0782 1.06e-27 120.0 COG1305@1|root,COG1305@2|Bacteria,1FZW2@1117|Cyanobacteria,1GZT0@1129|Synechococcus 1117|Cyanobacteria E Transglutaminase/protease-like homologues - - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_708008_2 1120951.AUBG01000009_gene3058 8.51e-63 200.0 COG1878@1|root,COG1878@2|Bacteria,4NFYB@976|Bacteroidetes,1IIVK@117743|Flavobacteriia 976|Bacteroidetes S Putative cyclase - - - - - - - - - - - - Cyclase k59_863206_1 98439.AJLL01000046_gene2307 3.2e-45 163.0 COG1404@1|root,COG1404@2|Bacteria,1G39Y@1117|Cyanobacteria 1117|Cyanobacteria O Subtilase family - - - - - - - - - - - - Peptidase_S8 k59_394409_2 765869.BDW_11695 3.63e-133 402.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2MSTJ@213481|Bdellovibrionales,2WJAZ@28221|Deltaproteobacteria 213481|Bdellovibrionales D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_394409_3 1232410.KI421421_gene3869 3.97e-76 241.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,43SXW@69541|Desulfuromonadales 28221|Deltaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_601714_1 330214.NIDE2930 7.47e-29 111.0 COG1230@1|root,COG1230@2|Bacteria,3J11Z@40117|Nitrospirae 40117|Nitrospirae P Cation efflux family - - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux k59_601714_2 330214.NIDE2928 5.77e-23 95.5 2CHNQ@1|root,2Z7KM@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_708013_1 765914.ThisiDRAFT_2131 4.5e-86 267.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1WVVC@135613|Chromatiales 135613|Chromatiales F TIGRFAM dihydroorotase, multifunctional complex type - - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_863208_1 472759.Nhal_1168 4.94e-90 271.0 2DWWN@1|root,32V2B@2|Bacteria,1NU0M@1224|Proteobacteria,1SKWT@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_708015_1 526222.Desal_2903 2.42e-06 49.3 2C477@1|root,32RDF@2|Bacteria,1RKW1@1224|Proteobacteria,42SWN@68525|delta/epsilon subdivisions,2WP88@28221|Deltaproteobacteria 28221|Deltaproteobacteria S DGC domain - - - - - - - - - - - - DGC k59_1384428_1 290397.Adeh_4214 3.02e-52 185.0 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2WITS@28221|Deltaproteobacteria,2YUCV@29|Myxococcales 28221|Deltaproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,PurS k59_289336_1 105559.Nwat_0930 1.34e-52 172.0 COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,1RMKJ@1236|Gammaproteobacteria,1WXKN@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1124774_1 1226994.AMZB01000119_gene3304 1.56e-28 110.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,1RNMF@1236|Gammaproteobacteria,1YCXB@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Protein of unknown function (DUF1722) ybgA - - - - - - - - - - - DUF1722,DUF523 k59_1497307_1 1238182.C882_0761 9.85e-08 53.9 COG3909@1|root,COG3909@2|Bacteria,1Q596@1224|Proteobacteria,2UISM@28211|Alphaproteobacteria,2JTXU@204441|Rhodospirillales 204441|Rhodospirillales C Cytochrome C' - - - - - - - - - - - - Cytochrom_C_2 k59_1497307_2 1038869.AXAN01000020_gene4087 3.09e-11 63.9 COG1999@1|root,COG1999@2|Bacteria,1RKIP@1224|Proteobacteria,2VS9B@28216|Betaproteobacteria,1K2MK@119060|Burkholderiaceae 28216|Betaproteobacteria S Electron transport protein SCO1 SenC - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_1593883_1 713586.KB900536_gene1300 6.6e-114 335.0 COG1052@1|root,COG1052@2|Bacteria,1MVSS@1224|Proteobacteria,1RMWR@1236|Gammaproteobacteria,1WX6C@135613|Chromatiales 135613|Chromatiales CH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.28,1.20.1.1 ko:K03778,ko:K18916 ko00620,ko01120,map00620,map01120 - R00704 RC00044 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_1650600_1 768671.ThimaDRAFT_0258 3.7e-39 132.0 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,1S3Q2@1236|Gammaproteobacteria,1WYDZ@135613|Chromatiales 135613|Chromatiales J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_1650600_2 95619.PM1_0200750 1.43e-52 171.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0000028,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006417,GO:0006446,GO:0006450,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030371,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031554,GO:0031564,GO:0032268,GO:0032269,GO:0032270,GO:0032991,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045727,GO:0045903,GO:0045947,GO:0048027,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990145,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_819912_3 436308.Nmar_1721 4e-35 130.0 COG0452@1|root,arCOG01704@2157|Archaea,41SYG@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine - - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_503900_1 1382304.JNIL01000001_gene220 1.19e-72 233.0 COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,4H9MX@91061|Bacilli,277WD@186823|Alicyclobacillaceae 91061|Bacilli E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_819914_2 1336233.JAEH01000050_gene4013 4.11e-36 140.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,2Q9CG@267890|Shewanellaceae 1236|Gammaproteobacteria T CBS domain containing protein - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_134456_1 1408423.JHYA01000005_gene1738 2.07e-12 63.2 2DNS1@1|root,32YVX@2|Bacteria,1VEGC@1239|Firmicutes,4H60B@909932|Negativicutes 909932|Negativicutes S Protein of unknown function (DUF2905) - - - - - - - - - - - - DUF2905 k59_134456_2 257363.RT0038 2.14e-14 70.1 COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2UBQU@28211|Alphaproteobacteria,47FNA@766|Rickettsiales 766|Rickettsiales J Belongs to the bacterial ribosomal protein bL28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k59_134456_3 1453500.AT05_09300 2.98e-09 54.3 COG0254@1|root,COG0254@2|Bacteria,4NS7P@976|Bacteroidetes,1I3YC@117743|Flavobacteriia 976|Bacteroidetes J Belongs to the bacterial ribosomal protein bL31 family rpmE2 - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_447236_1 1469245.JFBG01000019_gene1166 2.97e-43 154.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1WWTN@135613|Chromatiales 1236|Gammaproteobacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine csd - - - - - - - - - - - Aminotran_5 k59_863237_1 1500894.JQNN01000001_gene1494 8.04e-53 181.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VH1D@28216|Betaproteobacteria,473BB@75682|Oxalobacteraceae 28216|Betaproteobacteria C Oxidative deamination of D-amino acids dadA - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_87721_1 237368.SCABRO_01998 7.95e-159 466.0 COG1008@1|root,COG1008@2|Bacteria,2IX79@203682|Planctomycetes 203682|Planctomycetes C proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_1497348_1 330214.NIDE0836 3.86e-170 495.0 COG1048@1|root,COG1048@2|Bacteria,3J0E6@40117|Nitrospirae 40117|Nitrospirae C Aconitase C-terminal domain - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_916082_1 1397527.Q670_09335 1.67e-113 353.0 COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,1RNJ3@1236|Gammaproteobacteria,1XKXU@135619|Oceanospirillales 135619|Oceanospirillales M COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily - - - - - - - - - - - - Sulfatase k59_966767_1 760568.Desku_3108 1.55e-35 135.0 COG2079@1|root,COG2079@2|Bacteria,1TSD7@1239|Firmicutes,24BFZ@186801|Clostridia,260NH@186807|Peptococcaceae 1239|Firmicutes S PFAM MmgE PrpD - - - - - - - - - - - - MmgE_PrpD k59_601752_1 713586.KB900536_gene890 9.6e-67 211.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1WXZW@135613|Chromatiales 135613|Chromatiales L PFAM integrase - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_2 k59_819952_1 580340.Tlie_0284 5.45e-16 82.8 COG4191@1|root,COG4191@2|Bacteria,3TA1A@508458|Synergistetes 508458|Synergistetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA k59_179643_1 999547.KI421501_gene4018 1.76e-51 176.0 COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1MY9R@1224|Proteobacteria,2TTFW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the peptidase M50B family - - - ko:K06402 - - - - ko00000,ko01000,ko01002 - - - CBS,Peptidase_M50 k59_708066_2 431943.CKL_0584 2.36e-14 73.2 COG2020@1|root,COG2020@2|Bacteria,1V495@1239|Firmicutes,24IHG@186801|Clostridia,36FBJ@31979|Clostridiaceae 186801|Clostridia O Phospholipid methyltransferase - - - - - - - - - - - - PEMT k59_548943_1 631362.Thi970DRAFT_02073 1.99e-74 237.0 COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,1WWFE@135613|Chromatiales 135613|Chromatiales J Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs truD - 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_708067_1 686578.AFFX01000006_gene3306 1.46e-34 133.0 COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria 1224|Proteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_341627_1 445686.E3SL18_9CAUD 4.02e-10 59.3 4QHQV@10239|Viruses,4QX6C@35237|dsDNA viruses no RNA stage,4QRJ7@28883|Caudovirales,4QIJU@10662|Myoviridae 10662|Myoviridae S virus tail assembly - - - - - - - - - - - - - k59_341627_2 555387.C7BVC1_9CAUD 1.62e-15 75.1 4QB1K@10239|Viruses,4QUUK@35237|dsDNA viruses no RNA stage,4QPBK@28883|Caudovirales,4QI9B@10662|Myoviridae 10662|Myoviridae S Gene 25-like lysozyme - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098025 - - - - - - - - - - - k59_609765_1 566466.NOR53_1657 1.4e-53 190.0 COG1629@1|root,COG4771@2|Bacteria,1N6JG@1224|Proteobacteria,1RP10@1236|Gammaproteobacteria,1J704@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG4771 Outer membrane receptor for ferrienterochelin and colicins - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec k59_609774_1 543632.JOJL01000121_gene9849 1.16e-26 108.0 COG1321@1|root,COG1321@2|Bacteria,2GN2R@201174|Actinobacteria 201174|Actinobacteria K iron dependent repressor - - - - - - - - - - - - - k59_1392621_1 1519464.HY22_07630 2.67e-16 85.1 COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_1180982_1 1254432.SCE1572_23710 5.39e-33 125.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,42MBY@68525|delta/epsilon subdivisions,2WIR5@28221|Deltaproteobacteria,2YUKC@29|Myxococcales 28221|Deltaproteobacteria C alcohol dehydrogenase - - 1.1.1.61 ko:K00043 ko00650,ko01100,ko01200,map00650,map01100,map01200 - R01644 RC00087 ko00000,ko00001,ko01000 - - - Fe-ADH k59_1510244_1 443143.GM18_0341 5.92e-43 159.0 COG2133@1|root,COG2133@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - - - - - - - - - - - k59_1028339_1 522306.CAP2UW1_0936 1.44e-16 83.2 COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VIAV@28216|Betaproteobacteria 28216|Betaproteobacteria T protein phosphatase 2C domain protein pphA - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_1135871_1 177437.HRM2_48490 5.58e-48 169.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2MJIJ@213118|Desulfobacterales 28221|Deltaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1542591_1 439235.Dalk_1526 6.63e-42 159.0 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,42NXT@68525|delta/epsilon subdivisions,2WIZ3@28221|Deltaproteobacteria,2MKIU@213118|Desulfobacterales 28221|Deltaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,Pkinase,TPR_12 k59_245364_1 644282.Deba_1863 3.01e-66 224.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42MI5@68525|delta/epsilon subdivisions,2WITQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1,ECH_2 k59_871942_2 1121423.JONT01000003_gene1046 1e-20 88.6 COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,24ND7@186801|Clostridia,2629N@186807|Peptococcaceae 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iHN637.CLJU_RS01195 ATP-synt_DE,ATP-synt_DE_N k59_1510270_1 485913.Krac_10824 1.25e-16 82.8 COG5659@1|root,COG5659@2|Bacteria 2|Bacteria L transposition - - - - - - - - - - - - DDE_5 k59_1510270_2 192952.MM_1987 1.17e-14 73.2 arCOG02140@1|root,arCOG02140@2157|Archaea,2Y3PW@28890|Euryarchaeota,2NAX9@224756|Methanomicrobia 2157|Archaea S IS1 transposase - - - - - - - - - - - - DDE_Tnp_IS1 k59_1028354_1 1522072.IL54_0049 1.6e-66 215.0 COG2141@1|root,COG2141@2|Bacteria,1R9CH@1224|Proteobacteria,2U6WF@28211|Alphaproteobacteria,2K42R@204457|Sphingomonadales 204457|Sphingomonadales C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1392641_1 330214.NIDE0853 3.92e-47 162.0 COG4105@1|root,COG4105@2|Bacteria,3J0UU@40117|Nitrospirae 40117|Nitrospirae S Tetratricopeptide repeat - - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_871949_1 506534.Rhein_0499 1.53e-27 116.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales 135613|Chromatiales D DNA segregation ATPase FtsK SpoIIIE - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_457726_1 748280.NH8B_2016 9.82e-40 139.0 2DMK8@1|root,32S5F@2|Bacteria,1NNIY@1224|Proteobacteria,2VUQF@28216|Betaproteobacteria,2KT6F@206351|Neisseriales 206351|Neisseriales S Lipocalin-like domain - - - - - - - - - - - - Lipocalin_5 k59_871960_1 1121920.AUAU01000037_gene2735 1.08e-52 181.0 COG0119@1|root,COG0119@2|Bacteria,3Y2WT@57723|Acidobacteria 57723|Acidobacteria E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_558335_1 882378.RBRH_00455 4.92e-18 82.4 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2VP9S@28216|Betaproteobacteria,1K0PK@119060|Burkholderiaceae 28216|Betaproteobacteria L Evidence 2b Function of strongly homologous gene - - - - - - - - - - - - IstB_IS21 k59_352437_2 95619.PM1_0218260 1.21e-14 71.2 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_975969_1 1211115.ALIQ01000208_gene3357 2.26e-06 48.9 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2TS6I@28211|Alphaproteobacteria,3NAX6@45404|Beijerinckiaceae 28211|Alphaproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_975969_2 765913.ThidrDRAFT_4109 1.04e-21 91.3 COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,1SD3P@1236|Gammaproteobacteria,1WZFD@135613|Chromatiales 135613|Chromatiales U PFAM Preprotein translocase SecG subunit secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_457751_1 247639.MGP2080_08304 8.43e-26 110.0 COG3746@1|root,COG3746@2|Bacteria,1N2GT@1224|Proteobacteria,1T0R6@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Phosphate-selective porin O and P - - - - - - - - - - - - Porin_O_P k59_1181033_2 265072.Mfla_2079 1.63e-10 63.5 2DP0A@1|root,3300Q@2|Bacteria,1N78Y@1224|Proteobacteria,2VVZ5@28216|Betaproteobacteria,2KMZB@206350|Nitrosomonadales 206350|Nitrosomonadales S PFAM Sporulation domain protein - - - - - - - - - - - - - k59_1663662_1 1304275.C41B8_05453 1.9e-48 177.0 COG0234@1|root,COG0234@2|Bacteria,1NJKP@1224|Proteobacteria 1224|Proteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - - k59_976001_1 1230341.MJ3_13589 6.3e-47 171.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1TSMG@1239|Firmicutes,4HBFH@91061|Bacilli 91061|Bacilli S Terminase-like family - - - - - - - - - - - - Terminase_6,Terminase_6C k59_516930_1 941449.dsx2_3022 5.73e-23 90.1 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,42V30@68525|delta/epsilon subdivisions,2WRH7@28221|Deltaproteobacteria,2MCHE@213115|Desulfovibrionales 28221|Deltaproteobacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_1542673_1 1038869.AXAN01000117_gene4541 5.45e-52 178.0 COG3547@1|root,COG3547@2|Bacteria,1PWTR@1224|Proteobacteria,2WCCG@28216|Betaproteobacteria,1K7IV@119060|Burkholderiaceae 28216|Betaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1663673_1 1316936.K678_09393 6.03e-62 202.0 COG0517@1|root,COG1208@1|root,COG0517@2|Bacteria,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,2TS7U@28211|Alphaproteobacteria,2JR3Y@204441|Rhodospirillales 204441|Rhodospirillales JM Nucleotidyl transferase - - - - - - - - - - - - CBS,NTP_transferase k59_609864_1 1260251.SPISAL_00855 3.47e-52 172.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,1X2PM@135613|Chromatiales 135613|Chromatiales C TIGRFAM formate dehydrogenase, alpha subunit - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4 k59_1451219_1 935567.JAES01000004_gene48 4.26e-40 146.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1X44W@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the hydrolytic cleavage of a carbon-halogen bond in N-ethylammeline - - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_1451219_2 1031711.RSPO_c02460 1.01e-10 60.8 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2VHGP@28216|Betaproteobacteria,1K206@119060|Burkholderiaceae 28216|Betaproteobacteria H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_23 k59_1601968_1 1237149.C900_05256 3.6e-94 301.0 COG1131@1|root,COG1131@2|Bacteria,4NHPD@976|Bacteroidetes,47KQD@768503|Cytophagia 976|Bacteroidetes V ABC-2 type transporter - - - - - - - - - - - - ABC2_membrane,ABC_tran,TerB k59_1451221_1 1229909.NSED_02795 1.41e-101 299.0 COG0169@1|root,arCOG02097@2157|Archaea,41SKU@651137|Thaumarchaeota 651137|Thaumarchaeota E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate aroD - 4.2.1.10 ko:K03785 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_I k59_1302834_1 1307761.L21SP2_1902 2.34e-153 450.0 COG0028@1|root,COG0028@2|Bacteria,2J5EZ@203691|Spirochaetes 203691|Spirochaetes H TIGRFAM acetolactate synthase, large subunit, biosynthetic type - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_675837_1 1254432.SCE1572_36755 1.18e-12 66.6 COG0517@1|root,COG0517@2|Bacteria 2|Bacteria S IMP dehydrogenase activity - - - - - - - - - - - - CBS k59_675837_2 1047013.AQSP01000109_gene2441 8.14e-63 202.0 COG0500@1|root,COG2226@2|Bacteria,2NP8K@2323|unclassified Bacteria 2|Bacteria Q ubiE/COQ5 methyltransferase family arsM - 2.1.1.137,2.1.1.79 ko:K00574,ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 k59_516951_1 335543.Sfum_2352 1.37e-34 136.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42N93@68525|delta/epsilon subdivisions,2WJ9N@28221|Deltaproteobacteria,2MQI5@213462|Syntrophobacterales 28221|Deltaproteobacteria P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC k59_144682_1 983545.Glaag_2177 1.01e-05 48.5 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,466GX@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases anr - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_144682_2 748658.KB907312_gene1943 2.33e-56 186.0 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,1WXWD@135613|Chromatiales 135613|Chromatiales S Cytochrome C biogenesis protein transmembrane region - - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_144682_3 713587.THITH_16495 2.71e-44 163.0 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1WXM6@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_872028_1 1121405.dsmv_2453 2.99e-30 123.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2X7E0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - 2.7.13.3 ko:K07678 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Response_reg k59_1392711_1 444860.E3SIZ9_9CAUD 4.78e-68 218.0 4QASK@10239|Viruses,4QVVS@35237|dsDNA viruses no RNA stage,4QQFF@28883|Caudovirales,4QIHH@10662|Myoviridae 10662|Myoviridae S Pfam:T4-gp15_tss - GO:0005575,GO:0019012 - - - - - - - - - - - k59_300395_1 436308.Nmar_1135 3.69e-10 62.0 COG0421@1|root,arCOG00050@2157|Archaea 2157|Archaea H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth k59_766961_1 268746.Q58N03_BPPRM 4.34e-29 105.0 4QHYU@10662|Myoviridae 10662|Myoviridae S Pfam:Trans_coact - - - - - - - - - - - - - k59_766961_2 445686.E3SL46_9CAUD 4.2e-18 77.4 4QCTK@10239|Viruses,4QZ7Q@35237|dsDNA viruses no RNA stage,4QQCT@28883|Caudovirales,4QJR2@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_766961_3 268746.Q58MZ8_BPPRM 1.51e-32 117.0 4QC69@10239|Viruses,4QWAY@35237|dsDNA viruses no RNA stage,4QPPC@28883|Caudovirales,4QHVU@10662|Myoviridae 10662|Myoviridae S T4 gene Gp59 loader of gp41 DNA helicase - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_1302857_1 1260251.SPISAL_05935 1.92e-98 314.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1WW62@135613|Chromatiales 135613|Chromatiales L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1181080_1 460265.Mnod_2285 3.17e-34 133.0 28JZZ@1|root,2Z9PZ@2|Bacteria,1N3C6@1224|Proteobacteria,2TSCX@28211|Alphaproteobacteria,1JTZB@119045|Methylobacteriaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1135999_1 1356852.N008_11660 2.42e-30 120.0 COG1012@1|root,COG1012@2|Bacteria,4NFPJ@976|Bacteroidetes,47JJR@768503|Cytophagia 976|Bacteroidetes C Belongs to the aldehyde dehydrogenase family pcd - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_675877_1 378806.STAUR_7722 1.24e-66 221.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YWK2@29|Myxococcales 28221|Deltaproteobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_187822_1 1003200.AXXA_21158 1.28e-37 132.0 COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2VR8D@28216|Betaproteobacteria,3T3VS@506|Alcaligenaceae 28216|Betaproteobacteria CO Thiol disulfide interchange protein ccmG - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA,Redoxin k59_675885_1 653733.Selin_1953 8.28e-05 45.4 COG0209@1|root,COG0209@2|Bacteria 2|Bacteria F ribonucleoside-diphosphate reductase activity nrdZ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD k59_144707_2 1123368.AUIS01000012_gene773 2.34e-33 123.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,2NBTN@225057|Acidithiobacillales 225057|Acidithiobacillales H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives - - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_99111_1 1158318.ATXC01000001_gene271 8.49e-33 119.0 COG0290@1|root,COG0290@2|Bacteria,2G432@200783|Aquificae 200783|Aquificae J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_99111_2 568816.Acin_0900 1.01e-16 81.6 COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,4H2NX@909932|Negativicutes 909932|Negativicutes J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_833048_2 439235.Dalk_3968 1.33e-30 120.0 COG5323@1|root,COG5323@2|Bacteria,1R049@1224|Proteobacteria,42UYF@68525|delta/epsilon subdivisions 1224|Proteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6 k59_300431_1 1249627.D779_2627 4.39e-114 342.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1WVXY@135613|Chromatiales 135613|Chromatiales J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_1511454_1 1121033.AUCF01000022_gene500 4.76e-27 119.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U2CU@28211|Alphaproteobacteria,2JSFJ@204441|Rhodospirillales 204441|Rhodospirillales M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_246238_1 1123258.AQXZ01000018_gene894 4.83e-86 276.0 COG0155@1|root,COG0155@2|Bacteria,2GJRN@201174|Actinobacteria,4G1CI@85025|Nocardiaceae 201174|Actinobacteria C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family - - 1.7.7.1,1.8.1.2,1.8.7.1 ko:K00366,ko:K00381,ko:K00392 ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120 M00176,M00531 R00790,R00858,R00859,R03600 RC00065,RC00176 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_145418_1 1089545.KB913037_gene2905 1.37e-48 167.0 COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4E15U@85010|Pseudonocardiales 201174|Actinobacteria C Luciferase-like monooxygenase - - 1.14.14.5 ko:K04091 ko00920,map00920 - R07210,R10206 RC01779,RC02556 ko00000,ko00001,ko01000 - - - Bac_luciferase k59_188566_1 1232410.KI421420_gene3191 6.08e-20 90.9 2E9GQ@1|root,333PU@2|Bacteria,1NBP0@1224|Proteobacteria,4319S@68525|delta/epsilon subdivisions,2WRGY@28221|Deltaproteobacteria,43VF6@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_145423_1 504832.OCAR_4945 5.47e-13 68.9 COG0730@1|root,COG0730@2|Bacteria,1MWAN@1224|Proteobacteria,2TS4X@28211|Alphaproteobacteria,3JS3F@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S membrane transporter protein MA20_06400 - - ko:K07090 - - - - ko00000 - - - TauE k59_1511476_1 3750.XP_008349640.1 7.42e-11 61.6 COG2801@1|root,KOG1192@1|root,KOG0017@2759|Eukaryota,KOG1192@2759|Eukaryota,37RRH@33090|Viridiplantae,3G8MV@35493|Streptophyta,4JM10@91835|fabids 35493|Streptophyta H transposition, RNA-mediated - - - - - - - - - - - - Asp_protease_2,Chromo,RVP_2,RVT_1,Retrotrans_gag,gag-asp_proteas,rve k59_1084776_1 1158345.JNLL01000001_gene410 1.18e-69 223.0 COG1140@1|root,COG1140@2|Bacteria,2G4XI@200783|Aquificae 200783|Aquificae C 4Fe-4S dicluster domain - - 1.7.5.1 ko:K00371,ko:K17051 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8 - - Fer4_11 k59_1337963_2 187272.Mlg_0173 1.37e-22 95.1 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1WWAV@135613|Chromatiales 135613|Chromatiales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_256116_1 1121033.AUCF01000031_gene69 9.07e-63 207.0 COG0477@1|root,COG2814@2|Bacteria,1QW9T@1224|Proteobacteria,2TY4I@28211|Alphaproteobacteria,2JYY6@204441|Rhodospirillales 204441|Rhodospirillales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1039049_1 379731.PST_0549 3.64e-81 266.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1Z0AH@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_622746_1 330214.NIDE2200 1.96e-63 213.0 COG1413@1|root,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity - - - - - - - - - - - - HEAT_2,PT-HINT,Sulfatase k59_312473_1 1541065.JRFE01000023_gene3798 6.89e-28 114.0 COG3637@1|root,COG3637@2|Bacteria,1G4TB@1117|Cyanobacteria 1117|Cyanobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_200707_1 686340.Metal_0382 4.01e-73 235.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,1RN2U@1236|Gammaproteobacteria,1XDXE@135618|Methylococcales 135618|Methylococcales C PFAM Cytochrome bd ubiquinol oxidase, subunit I - - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_1192779_1 153948.NAL212_1477 3.63e-106 331.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,3724V@32003|Nitrosomonadales 28216|Betaproteobacteria I acyl-CoA dehydrogenase fadE - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_1348981_1 981327.F925_02752 3.45e-14 77.4 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,3NIPA@468|Moraxellaceae 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_364187_2 710111.FraQA3DRAFT_3012 4.2e-52 172.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase crtF - - - - - - - - - - - Methyltransf_11,Methyltransf_2,Methyltransf_23 k59_1610758_1 546266.NEIMUCOT_05730 6.03e-42 148.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2VI8C@28216|Betaproteobacteria,2KPNN@206351|Neisseriales 206351|Neisseriales F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_986418_1 330214.NIDE2481 4.12e-49 165.0 COG0489@1|root,COG0489@2|Bacteria,3J0Z6@40117|Nitrospirae 40117|Nitrospirae D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - ParA k59_200737_1 118163.Ple7327_0553 4.36e-32 119.0 COG1216@1|root,COG1216@2|Bacteria,1G0X3@1117|Cyanobacteria,3VNHT@52604|Pleurocapsales 1117|Cyanobacteria S Glycosyltransferase like family 2 - - - ko:K09931 - - - - ko00000 - - - DUF2064,Glycos_transf_2 k59_200737_2 1487956.DR71_446 2.77e-14 70.1 COG0663@1|root,COG0663@2|Bacteria,2GP22@201174|Actinobacteria,22MWU@1653|Corynebacteriaceae 201174|Actinobacteria S Carbonic anhydrases acetyltransferases, isoleucine patch superfamily gca GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008270,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043168,GO:0043169,GO:0043199,GO:0046872,GO:0046914,GO:0050897,GO:0071890,GO:1901681 - ko:K02617 - - - - ko00000 - - - Hexapep k59_1404335_1 1163408.UU9_09632 1.16e-19 84.7 COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,1S24N@1236|Gammaproteobacteria,1X6RD@135614|Xanthomonadales 135614|Xanthomonadales S Domain of unknown function (DUF1993) - - - ko:K09983 - - - - ko00000 - - - DUF1993 k59_1404335_2 1279017.AQYJ01000028_gene2273 2.13e-27 111.0 COG3468@1|root,COG3468@2|Bacteria,1NTR4@1224|Proteobacteria,1T238@1236|Gammaproteobacteria,465K5@72275|Alteromonadaceae 1236|Gammaproteobacteria MU Protein of unknown function (DUF3014) - - - - - - - - - - - - DUF3014 k59_312516_1 204669.Acid345_1537 3e-12 69.3 COG0001@1|root,COG0001@2|Bacteria,3Y3GA@57723|Acidobacteria,2JINJ@204432|Acidobacteriia 57723|Acidobacteria H PFAM Aminotransferase class-III - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_415669_1 525897.Dbac_1916 1.49e-39 146.0 COG0845@1|root,COG0845@2|Bacteria,1R4JA@1224|Proteobacteria,42SQN@68525|delta/epsilon subdivisions,2WP8X@28221|Deltaproteobacteria,2MAGW@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K21137 - M00821 - - ko00000,ko00002,ko02000 2.A.6.2.27,8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_882707_1 472759.Nhal_2359 5.33e-61 208.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_939568_1 472759.Nhal_1615 6.01e-124 367.0 COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,1RP1B@1236|Gammaproteobacteria,1WZVK@135613|Chromatiales 135613|Chromatiales C Prokaryotic cytochrome b561 - - - ko:K00127 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Ni_hydr_CYTB k59_312549_1 1366050.N234_09150 1.09e-22 100.0 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2VMGK@28216|Betaproteobacteria,1KI0E@119060|Burkholderiaceae 28216|Betaproteobacteria I acetyl-coa acetyltransferase - - - - - - - - - - - - Thiolase_C k59_312550_2 1336243.JAEA01000001_gene1664 8.07e-86 260.0 COG3576@1|root,COG3576@2|Bacteria,1MWG9@1224|Proteobacteria,2TSKK@28211|Alphaproteobacteria,1JUQS@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM Pyridoxamine 5'-phosphate MA20_21430 - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_986470_1 443143.GM18_0009 7.4e-19 88.6 COG0745@1|root,COG5002@1|root,COG0745@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42QJF@68525|delta/epsilon subdivisions,2WJ9D@28221|Deltaproteobacteria,43TUZ@69541|Desulfuromonadales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_4,Response_reg k59_728232_1 102125.Xen7305DRAFT_00021970 4.85e-26 100.0 COG3011@1|root,COG3011@2|Bacteria,1G5AK@1117|Cyanobacteria,3VJR4@52604|Pleurocapsales 1117|Cyanobacteria S Protein of unknown function, DUF393 - - - - - - - - - - - - DUF393 k59_1192867_2 589924.Ferp_1901 2.39e-06 47.0 COG1553@1|root,arCOG02068@2157|Archaea,2Y6XQ@28890|Euryarchaeota,2478Y@183980|Archaeoglobi 183980|Archaeoglobi P DsrE/DsrF-like family - - - ko:K06039 - - - - ko00000 - - - DrsE k59_1349064_1 667014.Thein_1460 3.95e-56 196.0 COG0480@1|root,COG0480@2|Bacteria,2GH6R@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_312564_1 1049564.TevJSym_bb00050 3.61e-65 218.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1557503_1 153721.MYP_4944 9.86e-09 61.2 2C852@1|root,32YB2@2|Bacteria,4NM63@976|Bacteroidetes,47SHZ@768503|Cytophagia 976|Bacteroidetes S Domain of unknown function (DUF4136) - - - - - - - - - - - - DUF4136 k59_625089_1 1499967.BAYZ01000019_gene6269 0.000284 49.3 COG2199@1|root,COG5002@1|root,COG3706@2|Bacteria,COG5002@2|Bacteria,2NQK2@2323|unclassified Bacteria 2|Bacteria T diguanylate cyclase exsG - - - - - - - - - - - GGDEF,HATPase_c,HATPase_c_2,HWE_HK,HisKA_2,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SpoIIE,dCache_1 k59_625102_1 330214.NIDE2918 4.29e-58 196.0 COG0154@1|root,COG0154@2|Bacteria,3J0AA@40117|Nitrospirae 40117|Nitrospirae J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_625110_1 331869.BAL199_10602 7.86e-74 241.0 COG0747@1|root,COG0747@2|Bacteria,1MU3P@1224|Proteobacteria,2TT4M@28211|Alphaproteobacteria,4BPY6@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_729625_1 629773.AORY01000001_gene2281 1.1e-39 148.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2TRDD@28211|Alphaproteobacteria,2K0XY@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_729625_2 880072.Desac_0688 0.000709 42.4 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,42NPN@68525|delta/epsilon subdivisions,2WIY4@28221|Deltaproteobacteria,2MR09@213462|Syntrophobacterales 28221|Deltaproteobacteria H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K00795,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_988768_1 1286170.RORB6_18155 5.15e-54 189.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_257580_1 886293.Sinac_1688 1.05e-98 300.0 COG3033@1|root,COG3033@2|Bacteria,2J41D@203682|Planctomycetes 203682|Planctomycetes E Beta-eliminating lyase - - 4.1.99.1 ko:K01667 ko00380,map00380 - R00673 RC00209,RC00355 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_625140_1 502025.Hoch_5784 9.44e-64 210.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,42MPG@68525|delta/epsilon subdivisions,2WKW8@28221|Deltaproteobacteria 28221|Deltaproteobacteria HJ RimK-like ATPgrasp N-terminal domain - - - - - - - - - - - - Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK k59_1040449_1 238854.Q5GQC8_BPSYP 2.71e-11 69.7 4QGTP@10239|Viruses,4R0J6@35237|dsDNA viruses no RNA stage,4QT4W@28883|Caudovirales,4QI00@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_203105_1 1329516.JPST01000006_gene1613 1.51e-73 238.0 COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,4HAB3@91061|Bacilli,27B3N@186824|Thermoactinomycetaceae 91061|Bacilli L DbpA RNA binding domain deaD - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_570631_1 1123368.AUIS01000006_gene681 1.14e-08 56.2 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,2NCDB@225057|Acidithiobacillales 225057|Acidithiobacillales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_570631_2 580332.Slit_1196 1.15e-29 118.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2VJ54@28216|Betaproteobacteria 28216|Betaproteobacteria O Belongs to the peptidase S16 family - - - - - - - - - - - - AAA_32,Lon_C k59_1557622_1 1229909.NSED_03705 1.27e-118 350.0 COG1173@1|root,arCOG00749@2157|Archaea,41SFE@651137|Thaumarchaeota 651137|Thaumarchaeota P inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1194830_1 1288494.EBAPG3_9670 2.61e-91 298.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,37253@32003|Nitrosomonadales 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1557627_1 1211279.S4SGQ4_9CAUD 7.86e-21 100.0 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_1612064_1 589924.Ferp_1191 1.03e-37 141.0 COG2141@1|root,arCOG02410@2157|Archaea,2XV6G@28890|Euryarchaeota,246P8@183980|Archaeoglobi 183980|Archaeoglobi C Luciferase-like monooxygenase - - - ko:K14728 - - - - ko00000,ko01000 - - - Bac_luciferase k59_570637_1 224911.27351908 4.24e-12 71.6 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2V82Q@28211|Alphaproteobacteria,3JZF5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_625235_1 1379698.RBG1_1C00001G0025 4.8e-58 191.0 COG1005@1|root,COG1005@2|Bacteria,2NQIK@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 ko:K00337,ko:K05572 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_625237_1 945550.VISI1226_01015 5.19e-20 91.7 COG0847@1|root,COG0847@2|Bacteria,1RAF1@1224|Proteobacteria,1S9PP@1236|Gammaproteobacteria,1XVPY@135623|Vibrionales 135623|Vibrionales L EXOIII - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_1194858_2 1033740.CAEW01000002_gene1172 2.25e-25 99.0 COG2201@1|root,COG2201@2|Bacteria,1VBZF@1239|Firmicutes,4HKVG@91061|Bacilli,26FX3@186818|Planococcaceae 91061|Bacilli NT cheY-homologous receiver domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_1406363_1 234267.Acid_7035 1.51e-63 218.0 COG0587@1|root,COG0587@2|Bacteria,3Y3YK@57723|Acidobacteria 57723|Acidobacteria L Belongs to the DNA polymerase type-C family. DnaE2 subfamily - - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_625260_1 436308.Nmar_0053 1.72e-114 338.0 COG1679@1|root,arCOG04278@2157|Archaea,41SBC@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF521) - - - ko:K09123 - - - - ko00000 - - - DUF521 k59_988896_1 1189620.AJXL01000010_gene2582 1.84e-22 100.0 COG0471@1|root,COG0471@2|Bacteria,4NF52@976|Bacteroidetes,1HWTJ@117743|Flavobacteriia,2NVF2@237|Flavobacterium 976|Bacteroidetes P Sodium:sulfate symporter transmembrane region - - - - - - - - - - - - CitMHS,TrkA_C k59_1557691_1 1304885.AUEY01000026_gene3547 2.63e-57 192.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,42M7V@68525|delta/epsilon subdivisions,2WIUB@28221|Deltaproteobacteria,2MIV4@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_203217_1 1122603.ATVI01000005_gene3333 9.85e-37 133.0 COG1234@1|root,COG1234@2|Bacteria,1QU4B@1224|Proteobacteria,1S453@1236|Gammaproteobacteria,1X5NV@135614|Xanthomonadales 135614|Xanthomonadales S cAMP phosphodiesterases class-II - - - - - - - - - - - - Lactamase_B_2 k59_203219_1 1282876.BAOK01000002_gene892 4.18e-45 160.0 COG0477@1|root,COG0477@2|Bacteria,1R02N@1224|Proteobacteria,2TYHV@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_778757_1 1215092.PA6_028_01190 8.04e-22 92.4 COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,1S2G7@1236|Gammaproteobacteria,1YH76@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S VIT family - - - - - - - - - - - - VIT1 k59_778757_2 1200567.JNKD01000095_gene1046 5.19e-13 69.3 COG2173@1|root,COG2173@2|Bacteria,1RENK@1224|Proteobacteria,1S3SJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide ddpX GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009046,GO:0009605,GO:0009991,GO:0016787,GO:0019538,GO:0031667,GO:0042594,GO:0043170,GO:0044238,GO:0050896,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.13.22 ko:K08641 ko01502,ko02020,map01502,map02020 M00651 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 - - - Peptidase_M15 k59_23303_1 1323663.AROI01000006_gene3013 5.07e-107 320.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_23303_2 1026882.MAMP_03108 9.99e-148 427.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,46048@72273|Thiotrichales 72273|Thiotrichales D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_203242_1 713587.THITH_01410 2.04e-73 223.0 COG1146@1|root,COG1146@2|Bacteria,1R4GP@1224|Proteobacteria,1RXXW@1236|Gammaproteobacteria,1WVWW@135613|Chromatiales 135613|Chromatiales C reductase beta subunit - - 1.8.99.2 ko:K00395 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - APS-reductase_C,Fer4,Fer4_9 k59_778767_1 479434.Sthe_3015 6.23e-77 248.0 COG0318@1|root,COG0318@2|Bacteria,2G7PF@200795|Chloroflexi,27XJD@189775|Thermomicrobia 189775|Thermomicrobia IQ Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily menE - 6.2.1.26 ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C k59_988941_1 1469245.JFBG01000030_gene1542 6.56e-54 177.0 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,1RS9K@1236|Gammaproteobacteria,1WYDE@135613|Chromatiales 135613|Chromatiales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain msrQ - - ko:K17247 - - - - ko00000 - - - Ferric_reduct k59_203248_1 478741.JAFS01000001_gene1903 2.5e-06 49.7 COG0125@1|root,COG0125@2|Bacteria,46ST1@74201|Verrucomicrobia,37GRT@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_203248_2 998674.ATTE01000001_gene1686 5.34e-34 128.0 COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,460WJ@72273|Thiotrichales 72273|Thiotrichales L TIGRFAM DNA polymerase III, delta - - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C k59_1557747_1 391625.PPSIR1_27268 1.01e-37 135.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,42N8K@68525|delta/epsilon subdivisions,2WN0Z@28221|Deltaproteobacteria,2YUJN@29|Myxococcales 28221|Deltaproteobacteria G Glycosyl hydrolase family 3 N terminal domain nagZ - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_1406406_1 118173.KB235914_gene2486 3.43e-14 72.4 COG0577@1|root,COG0577@2|Bacteria,1G20M@1117|Cyanobacteria,1H7PU@1150|Oscillatoriales 1117|Cyanobacteria V DevC protein - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_1406406_2 1123242.JH636435_gene1084 1.11e-30 125.0 COG0845@1|root,COG0845@2|Bacteria,2J150@203682|Planctomycetes 203682|Planctomycetes M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1557769_1 247633.GP2143_12079 6.35e-08 53.5 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,1J4PP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0591 Na proline symporter cbrA - - - - - - - - - - - HATPase_c,HisKA,PAS k59_1194927_1 1229909.NSED_06185 4e-57 192.0 COG1530@1|root,arCOG00321@2157|Archaea,41T2C@651137|Thaumarchaeota 651137|Thaumarchaeota L modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1406427_1 748658.KB907313_gene2385 4.79e-126 380.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales 135613|Chromatiales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_994224_1 1279019.ARQK01000021_gene401 2e-140 435.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1151060_1 219305.MCAG_03778 4.64e-11 66.2 COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria,4DBWV@85008|Micromonosporales 201174|Actinobacteria H FO synthase fbiC - 2.5.1.77 ko:K11779 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_1151060_2 877455.Metbo_0327 5.26e-27 108.0 COG1060@1|root,arCOG00657@2157|Archaea,2XT78@28890|Euryarchaeota,23NJP@183925|Methanobacteria 183925|Methanobacteria H Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) cofG - 2.5.1.77 ko:K11780 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_890247_1 1229909.NSED_08930 1.39e-96 290.0 arCOG10597@1|root,arCOG10597@2157|Archaea 2157|Archaea O serine-type endopeptidase activity - - - - - - - - - - - - - k59_890247_2 1229909.NSED_08925 2.73e-91 284.0 arCOG08793@1|root,arCOG08812@1|root,arCOG08793@2157|Archaea,arCOG08812@2157|Archaea,41SXB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1464839_1 1279019.ARQK01000060_gene2208 1.59e-46 162.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1WX71@135613|Chromatiales 135613|Chromatiales I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_1464839_2 396588.Tgr7_1166 6.22e-57 189.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1WW2V@135613|Chromatiales 135613|Chromatiales M zinc metalloprotease - - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_54833_1 395493.BegalDRAFT_3347 3.33e-40 151.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,4600P@72273|Thiotrichales 72273|Thiotrichales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_524451_1 156889.Mmc1_0248 3.93e-64 209.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2TRMT@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1203999_1 1046714.AMRX01000003_gene141 8.93e-18 81.3 COG0678@1|root,COG0695@1|root,COG0678@2|Bacteria,COG0695@2|Bacteria,1MU0H@1224|Proteobacteria,1RRFB@1236|Gammaproteobacteria,464U1@72275|Alteromonadaceae 1236|Gammaproteobacteria O Glutaredoxin VY92_02980 - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - Glutaredoxin,Redoxin k59_1203999_2 1144310.PMI07_003681 1.56e-155 444.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,4BDWB@82115|Rhizobiaceae 28211|Alphaproteobacteria E Cobalamin-independent synthase, Catalytic domain metE - 2.1.1.14,4.4.1.23 ko:K00549,ko:K22363 ko00270,ko00450,ko00625,ko01100,ko01110,ko01230,map00270,map00450,map00625,map01100,map01110,map01230 M00017 R04405,R09365,R11897,R11899 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_2 k59_942072_1 395494.Galf_2123 6.39e-61 203.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,44VEU@713636|Nitrosomonadales 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_263339_1 1380356.JNIK01000015_gene2605 2.12e-16 81.3 COG1028@1|root,COG1028@2|Bacteria,2GW8A@201174|Actinobacteria,4EX5M@85013|Frankiales 201174|Actinobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_1464846_1 1198232.CYCME_0630 1.1e-33 127.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,4602X@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1464846_2 998088.B565_0173 1.44e-15 76.3 COG0596@1|root,COG0596@2|Bacteria,1QUBR@1224|Proteobacteria,1RSF9@1236|Gammaproteobacteria,1Y482@135624|Aeromonadales 135624|Aeromonadales S The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters bioH - 3.1.1.85 ko:K02170 ko00780,ko01100,map00780,map01100 M00572 R09725 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1 k59_733476_1 269799.Gmet_2580 4.64e-116 374.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_158142_1 1282876.BAOK01000002_gene552 6.73e-65 207.0 COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,2TSSU@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family MA20_16345 - - - - - - - - - - - ECH_1 k59_1046849_1 247490.KSU1_C0120 1.11e-137 428.0 COG0474@1|root,COG0474@2|Bacteria,2IXV7@203682|Planctomycetes 203682|Planctomycetes P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.2 ko:K01531 - - - - ko00000,ko01000 3.A.3.4 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,SBP_bac_1 k59_471843_1 497964.CfE428DRAFT_2269 8.4e-21 97.1 COG0612@1|root,COG0612@2|Bacteria,46VKF@74201|Verrucomicrobia 74201|Verrucomicrobia S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_1256165_1 179408.Osc7112_2732 9.41e-80 254.0 COG1249@1|root,COG1249@2|Bacteria,1G198@1117|Cyanobacteria,1H7PH@1150|Oscillatoriales 1117|Cyanobacteria C Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase merA - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_1464858_1 706587.Desti_4326 1.5e-40 152.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42MCH@68525|delta/epsilon subdivisions,2WJPZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_420007_1 1313172.YM304_00200 1.36e-44 157.0 COG0730@1|root,COG0730@2|Bacteria 2|Bacteria S response to heat - - - ko:K07090 - - - - ko00000 - - - TauE k59_1151083_1 305900.GV64_09645 5.83e-91 281.0 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,1RNJ9@1236|Gammaproteobacteria,1XHUF@135619|Oceanospirillales 135619|Oceanospirillales E Oxidoreductase - - - - - - - - - - - - DAO k59_1046853_1 1463921.JODF01000002_gene3120 9.34e-06 49.3 COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase fadE3_2 - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1046853_2 326424.FRAAL3092 1.66e-67 216.0 COG0183@1|root,COG0183@2|Bacteria,2IDAP@201174|Actinobacteria 201174|Actinobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_733487_1 1122194.AUHU01000011_gene1683 1.92e-63 209.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria,465X3@72275|Alteromonadaceae 1236|Gammaproteobacteria O COG1030 Membrane-bound serine protease (ClpP class) nfeD - - ko:K07403 - - - - ko00000 - - - NfeD k59_1204032_1 330214.NIDE0303 1.96e-103 313.0 COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae 2|Bacteria M Evidence 2a Function of homologous gene experimentally demonstrated in an other organism htrA GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_890280_1 2340.JV46_28110 2.74e-103 322.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1J4ZW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1307712_1 1115803.HMPREF1129_0138 2.99e-32 120.0 COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4D33V@85005|Actinomycetales 201174|Actinobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_1307712_2 1177594.MIC448_560020 7.06e-08 54.7 COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,2I81M@201174|Actinobacteria 201174|Actinobacteria K Cupin domain - - - - - - - - - - - - Cupin_2,HTH_3,HTH_31 k59_1488_2 292563.Cyast_0345 1.77e-07 57.0 COG4398@1|root,COG4398@2|Bacteria,1G0TB@1117|Cyanobacteria 1117|Cyanobacteria S PFAM FIST C domain - - - - - - - - - - - - FIST,FIST_C k59_524491_1 204669.Acid345_1270 1.66e-84 268.0 COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia 204432|Acidobacteriia Q Flavin containing amine oxidoreductase - - - - - - - - - - - - NAD_binding_8 k59_471864_1 864702.OsccyDRAFT_2062 4.61e-38 143.0 COG1253@1|root,COG1253@2|Bacteria,1G16U@1117|Cyanobacteria,1H75A@1150|Oscillatoriales 1117|Cyanobacteria S PFAM CBS domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1621511_1 436308.Nmar_1102 8.36e-35 129.0 COG3794@1|root,arCOG06255@1|root,arCOG02926@2157|Archaea,arCOG06255@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind k59_158162_1 543728.Vapar_3549 8.34e-15 81.6 COG0457@1|root,COG2197@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2197@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VPH8@28216|Betaproteobacteria,4AF3Y@80864|Comamonadaceae 28216|Betaproteobacteria K AAA ATPase domain - - - - - - - - - - - - AAA_16,BTAD k59_524493_1 1146883.BLASA_0999 1.96e-23 100.0 COG3291@1|root,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - - - - - - - - - - - PA,PKD k59_1046875_1 1307834.BARL01000003_gene1856 2.33e-22 101.0 COG1506@1|root,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TUXY@28211|Alphaproteobacteria,2JZPF@204441|Rhodospirillales 204441|Rhodospirillales E Prolyl oligopeptidase family - - - - - - - - - - - - Peptidase_S9 k59_576583_1 1048834.TC41_2650 1.85e-05 48.9 COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,4HADJ@91061|Bacilli 91061|Bacilli L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0050896 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_576583_2 1156919.QWC_07199 4.38e-23 100.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,2VJIT@28216|Betaproteobacteria,3T1HM@506|Alcaligenaceae 28216|Betaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.19,2.6.1.22 ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1046878_1 1335757.SPICUR_08290 1.62e-55 183.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1WWIK@135613|Chromatiales 135613|Chromatiales J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_1360402_1 98439.AJLL01000072_gene1223 1.74e-76 255.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1G2E2@1117|Cyanobacteria 1117|Cyanobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_263389_1 596151.DesfrDRAFT_3192 1.18e-61 203.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42MFT@68525|delta/epsilon subdivisions,2WIXC@28221|Deltaproteobacteria,2M7WT@213115|Desulfovibrionales 28221|Deltaproteobacteria P TIGRFAM Ammonium transporter amt - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_1516257_1 330214.NIDE3269 1.16e-122 360.0 COG3005@1|root,COG3005@2|Bacteria 2|Bacteria C denitrification pathway - - - - - - - - - - - - Cytochrome_C554 k59_1492_1 1304880.JAGB01000001_gene253 3.77e-60 198.0 COG0345@1|root,COG0345@2|Bacteria,1TP1E@1239|Firmicutes,247SR@186801|Clostridia 186801|Clostridia E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_1492_2 868864.Dester_0534 1.45e-29 113.0 COG0325@1|root,COG0325@2|Bacteria,2G3XD@200783|Aquificae 200783|Aquificae S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_786147_1 1280947.HY30_09210 1.02e-17 85.1 COG1960@1|root,COG1960@2|Bacteria,1R7HF@1224|Proteobacteria,2U3BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG1960 Acyl-CoA dehydrogenases - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_786147_2 402881.Plav_1872 9.21e-47 162.0 COG1960@1|root,COG1960@2|Bacteria,1P8I7@1224|Proteobacteria,2U0AW@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_158168_1 743719.PaelaDRAFT_2691 1.68e-14 78.2 COG1199@1|root,COG2176@1|root,COG1199@2|Bacteria,COG2176@2|Bacteria,1TQHQ@1239|Firmicutes,4HB2Y@91061|Bacilli,26T6Z@186822|Paenibacillaceae 91061|Bacilli L helicase involved in DNA repair and perhaps also replication dinG - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,Helicase_C_2,RNase_T,ResIII k59_681731_1 1033744.CAEL01000024_gene1659 5.97e-06 47.4 COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,24JCS@186801|Clostridia,22HJH@1570339|Peptoniphilaceae 186801|Clostridia J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_681731_2 97138.C820_00858 6.95e-61 194.0 COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,2496R@186801|Clostridia,36FMT@31979|Clostridiaceae 186801|Clostridia J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_681731_3 269799.Gmet_0640 7.77e-42 142.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,42SF6@68525|delta/epsilon subdivisions,2WPDP@28221|Deltaproteobacteria,43V2C@69541|Desulfuromonadales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_681731_4 251221.35214488 8.49e-28 105.0 COG0094@1|root,COG0094@2|Bacteria,1FZW3@1117|Cyanobacteria 1117|Cyanobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rpl5 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_471880_1 1283283.ATXA01000022_gene283 8.41e-52 180.0 COG2159@1|root,COG2159@2|Bacteria,2H94T@201174|Actinobacteria,4EWGY@85013|Frankiales 201174|Actinobacteria S amidohydrolase - - - - - - - - - - - - - k59_1256218_1 224325.AF_1002 2.08e-35 127.0 COG2062@1|root,arCOG01992@2157|Archaea,2Y26Y@28890|Euryarchaeota,24776@183980|Archaeoglobi 183980|Archaeoglobi T Histidine phosphatase superfamily (branch 1) - - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_1151119_1 472759.Nhal_0363 3.81e-89 291.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1X28I@135613|Chromatiales 135613|Chromatiales M Lysin motif - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_420053_1 1454202.PPBDW_50052___1 3.22e-07 58.2 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1XTP3@135623|Vibrionales 135623|Vibrionales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_471885_1 1047013.AQSP01000114_gene680 2.79e-28 117.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_576600_1 1229780.BN381_130221 1.84e-92 285.0 COG2159@1|root,COG2159@2|Bacteria,2GP2D@201174|Actinobacteria 201174|Actinobacteria S amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_263400_1 697282.Mettu_1817 2.97e-30 117.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1XDUW@135618|Methylococcales 135618|Methylococcales H Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit - - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_1621532_1 713586.KB900536_gene2573 9.96e-120 354.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RNPX@1236|Gammaproteobacteria,1WX9E@135613|Chromatiales 135613|Chromatiales E Belongs to the ABC transporter superfamily - - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 k59_1204084_1 652103.Rpdx1_3601 2.86e-99 300.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,3JR13@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Belongs to the thiolase family atoB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1204084_2 1207063.P24_11390 2.41e-77 241.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,2JPCY@204441|Rhodospirillales 204441|Rhodospirillales I COG1960 Acyl-CoA dehydrogenases - - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1621533_1 722419.PH505_ab01060 4.5e-59 185.0 COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,2Q2GT@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH GO:0001505,GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0017144,GO:0019464,GO:0019752,GO:0031405,GO:0031406,GO:0033293,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901681 - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - iE2348C_1286.E2348C_3156,iPC815.YPO0906 GCV_H k59_890322_1 443144.GM21_3877 2.93e-99 302.0 COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2WIYU@28221|Deltaproteobacteria,43STU@69541|Desulfuromonadales 28221|Deltaproteobacteria P Ion transport 2 domain protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_C,TrkA_N k59_1568959_1 420324.KI912061_gene6197 1.44e-68 235.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,1JR57@119045|Methylobacteriaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,Abhydrolase_1,Guanylate_cyc,TPR_4 k59_1493_1 986075.CathTA2_0970 5.23e-104 315.0 COG0150@1|root,COG0150@2|Bacteria,1TP9J@1239|Firmicutes,4HABW@91061|Bacilli 91061|Bacilli F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1204089_1 748247.AZKH_3610 2.41e-100 318.0 COG0367@1|root,COG0367@2|Bacteria,1PRFK@1224|Proteobacteria,2VJKQ@28216|Betaproteobacteria,2KV2F@206389|Rhodocyclales 206389|Rhodocyclales E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_786172_2 221288.JH992901_gene742 1.04e-05 51.2 COG1524@1|root,COG1524@2|Bacteria,1G4AF@1117|Cyanobacteria 1117|Cyanobacteria S type I phosphodiesterase nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_315708_1 1207063.P24_03645 8.63e-59 194.0 COG4448@1|root,COG4448@2|Bacteria,1R4NH@1224|Proteobacteria,2TV9J@28211|Alphaproteobacteria,2JQI6@204441|Rhodospirillales 204441|Rhodospirillales E L-asparaginase II - - - - - - - - - - - - Asparaginase_II k59_1046919_1 436308.Nmar_0006 1e-52 169.0 arCOG08807@1|root,arCOG08807@2157|Archaea,41SRC@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1046919_2 436308.Nmar_0005 1.8e-57 184.0 COG2241@1|root,arCOG00650@2157|Archaea,41SGN@651137|Thaumarchaeota 651137|Thaumarchaeota H TIGRFAM precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit - - 2.1.1.289 ko:K03399 ko00860,ko01100,map00860,map01100 - R05813,R07775 RC00003,RC02052,RC02053 ko00000,ko00001,ko01000 - - - TP_methylase k59_1152031_1 1160137.KB907307_gene2405 7.47e-60 196.0 COG4221@1|root,COG4221@2|Bacteria,2GP47@201174|Actinobacteria,4FZ6Y@85025|Nocardiaceae 201174|Actinobacteria S KR domain - - - - - - - - - - - - adh_short k59_1100183_1 243233.MCA3113 9.18e-92 288.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1XE6M@135618|Methylococcales 135618|Methylococcales S PFAM Polyphosphate kinase 2 - - - - - - - - - - - - PPK2 k59_1205215_2 1432050.IE4771_CH02964 1.29e-23 102.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2TRP4@28211|Alphaproteobacteria,4B8TY@82115|Rhizobiaceae 28211|Alphaproteobacteria O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_1257382_1 697282.Mettu_0386 4.21e-86 277.0 COG1234@1|root,COG1341@1|root,COG1234@2|Bacteria,COG1341@2|Bacteria,1PPRD@1224|Proteobacteria,1RRV8@1236|Gammaproteobacteria,1XFJE@135618|Methylococcales 135618|Methylococcales S Beta-lactamase superfamily domain - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_1152034_1 1229909.NSED_04245 4.47e-104 306.0 arCOG08714@1|root,arCOG08714@2157|Archaea,41SPW@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_264345_1 1304888.ATWF01000001_gene657 3.38e-28 111.0 COG0248@1|root,COG0248@2|Bacteria,2GFEH@200930|Deferribacteres 200930|Deferribacteres FP Ppx/GppA phosphatase family - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_264345_2 1151292.QEW_3015 3.98e-09 58.5 COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia,25QX4@186804|Peptostreptococcaceae 186801|Clostridia K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_585143_3 330214.NIDE4057 6.23e-23 92.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - - - - - - - - - - CopD,Cytochrome_CBB3 k59_640442_1 1380356.JNIK01000003_gene1205 3.39e-59 202.0 COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4ERMQ@85013|Frankiales 201174|Actinobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC copA - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_640442_2 1292373.H640_06724 1.46e-05 45.4 COG1937@1|root,COG1937@2|Bacteria,2IQAC@201174|Actinobacteria,4DRND@85009|Propionibacteriales 201174|Actinobacteria S Metal-sensitive transcriptional repressor csoR - - ko:K21600 - - - - ko00000,ko03000 - - - Trns_repr_metal k59_428631_1 56110.Oscil6304_0071 1.63e-38 141.0 COG0505@1|root,COG0505@2|Bacteria,1G19V@1117|Cyanobacteria,1H8WM@1150|Oscillatoriales 1117|Cyanobacteria F Belongs to the CarA family carA GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_428631_2 1158318.ATXC01000001_gene414 1.67e-80 265.0 COG0458@1|root,COG0458@2|Bacteria,2G3RR@200783|Aquificae 200783|Aquificae F PFAM Carbamoyl-phosphate synthase L chain carB2 GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_797469_1 765913.ThidrDRAFT_3014 7.57e-43 159.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1WWF7@135613|Chromatiales 135613|Chromatiales H TonB-dependent Receptor Plug - - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_1475235_1 649638.Trad_1301 6.03e-55 188.0 COG0415@1|root,COG0415@2|Bacteria,1WM2P@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L DNA photolyase - - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase k59_65900_1 1255043.TVNIR_3136 1.14e-108 325.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1WXI6@135613|Chromatiales 135613|Chromatiales F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_324763_1 471223.GWCH70_1375 2e-11 66.6 COG2761@1|root,COG2761@2|Bacteria,1TRSS@1239|Firmicutes,4HEP8@91061|Bacilli,1WHU7@129337|Geobacillus 91061|Bacilli Q Thioredoxin - - - - - - - - - - - - DSBA k59_324763_2 314607.KB13_427 5.81e-06 47.8 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2VHHJ@28216|Betaproteobacteria,1KPP6@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_640462_1 981223.AIED01000001_gene1750 1.43e-18 86.7 COG1946@1|root,COG1946@2|Bacteria,1MV9R@1224|Proteobacteria,1RPFI@1236|Gammaproteobacteria,3NINR@468|Moraxellaceae 1236|Gammaproteobacteria I Acyl-CoA thioesterase tesB - - ko:K10805 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT_3 k59_1577226_1 448385.sce2596 1.68e-35 137.0 COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,42YQ0@68525|delta/epsilon subdivisions,2WTRV@28221|Deltaproteobacteria,2YUFX@29|Myxococcales 28221|Deltaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - - k59_1107880_2 1274374.CBLK010000086_gene4585 3.99e-16 78.2 COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,4HAMU@91061|Bacilli,26QMU@186822|Paenibacillaceae 91061|Bacilli E Belongs to the cysteine synthase cystathionine beta- synthase family cysK GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0004122,GO:0004124,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008134,GO:0008144,GO:0008150,GO:0008152,GO:0008284,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016740,GO:0016765,GO:0016829,GO:0016835,GO:0016836,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0022607,GO:0030170,GO:0032991,GO:0032993,GO:0036094,GO:0042127,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043388,GO:0043436,GO:0043933,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046395,GO:0046983,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0051098,GO:0051099,GO:0051101,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051291,GO:0065003,GO:0065007,GO:0065009,GO:0070279,GO:0071704,GO:0071840,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1904796,GO:1904798,GO:2000677,GO:2000679 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_898966_1 34007.IT40_00800 4.54e-60 207.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2PUKE@265|Paracoccus 28211|Alphaproteobacteria P E1-E2 ATPase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_1522029_1 296591.Bpro_1648 5.74e-96 280.0 COG0346@1|root,COG0346@2|Bacteria,1RABI@1224|Proteobacteria,2VVN9@28216|Betaproteobacteria,4AI4B@80864|Comamonadaceae 28216|Betaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase_4 k59_1002687_1 1288494.EBAPG3_2370 4.76e-56 192.0 28H91@1|root,2Z7KU@2|Bacteria,1R4NB@1224|Proteobacteria,2VS45@28216|Betaproteobacteria,373Z4@32003|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_797515_2 445686.E3SL91_9CAUD 7.37e-28 112.0 4QCGC@10239|Viruses,4QZFA@35237|dsDNA viruses no RNA stage,4QTZH@28883|Caudovirales,4QJ8J@10662|Myoviridae 10662|Myoviridae S Domain of unknown function (DUF4338) - - - - - - - - - - - - - k59_640487_1 1232410.KI421412_gene79 7.97e-39 144.0 COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,42Z2N@68525|delta/epsilon subdivisions,2WTWI@28221|Deltaproteobacteria,43U2C@69541|Desulfuromonadales 28221|Deltaproteobacteria G Malonyl-CoA decarboxylase N-terminal domain - - - - - - - - - - - - MCD,MCD_N k59_1630329_2 1229909.NSED_09745 1.07e-57 192.0 COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger k59_1421671_1 370438.PTH_1335 3.75e-54 182.0 COG2301@1|root,COG2301@2|Bacteria,1TPDY@1239|Firmicutes,24AIH@186801|Clostridia,260C4@186807|Peptococcaceae 186801|Clostridia G Belongs to the HpcH HpaI aldolase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_114538_1 986075.CathTA2_1436 4.38e-106 320.0 COG1960@1|root,COG1960@2|Bacteria,1UK89@1239|Firmicutes,4HAR5@91061|Bacilli 91061|Bacilli I acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1107896_1 1197906.CAJQ02000011_gene832 1.49e-13 73.2 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,3JWTH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1107896_2 1208323.B30_10180 2.69e-84 257.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2U44W@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0411 ABC-type branched-chain amino acid transport systems ATPase component - - - - - - - - - - - - ABC_tran,BCA_ABC_TP_C k59_898985_1 383372.Rcas_0224 9.83e-55 175.0 COG2010@1|root,COG2010@2|Bacteria,2G6R3@200795|Chloroflexi,377DZ@32061|Chloroflexia 32061|Chloroflexia C Haem-binding domain - - - - - - - - - - - - Haem_bd k59_1522037_1 436308.Nmar_1522 1.21e-60 197.0 arCOG08643@1|root,arCOG08643@2157|Archaea,41T5M@651137|Thaumarchaeota 651137|Thaumarchaeota S peptidyl-tyrosine sulfation - - - - - - - - - - - - - k59_846556_1 1488328.JMCL01000109_gene4152 4.95e-14 71.6 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind k59_846556_2 523791.Kkor_1711 8.74e-41 143.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1XHW3@135619|Oceanospirillales 135619|Oceanospirillales J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_1002706_1 330214.NIDE0303 1.81e-58 200.0 COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae 2|Bacteria M Evidence 2a Function of homologous gene experimentally demonstrated in an other organism htrA GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_272083_1 589865.DaAHT2_0272 4.15e-42 155.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJF9@28221|Deltaproteobacteria,2MHRZ@213118|Desulfobacterales 28221|Deltaproteobacteria T response regulator receiver - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1159324_1 211114.JOEF01000053_gene4702 1.52e-28 117.0 COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4DY81@85010|Pseudonocardiales 201174|Actinobacteria K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form cobB - - - - - - - - - - - SIR2 k59_532886_1 330214.NIDE4183 5.13e-122 356.0 COG1063@1|root,COG1063@2|Bacteria 2|Bacteria E alcohol dehydrogenase tdh - 1.1.1.103,2.7.13.3 ko:K00060,ko:K07777 ko00260,ko02020,map00260,map02020 M00478 R01465 RC00525 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - ADH_N,ADH_zinc_N k59_1267247_1 1121405.dsmv_2568 8.53e-49 175.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales 28221|Deltaproteobacteria M TIGRFAM penicillin-binding protein, 1A family mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_640520_1 157072.XP_008871363.1 5.98e-57 195.0 COG1233@1|root,KOG4254@2759|Eukaryota 2759|Eukaryota Q all-trans-retinol 13,14-reductase activity PYROXD2 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0044464,GO:0055114 - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_324816_1 290397.Adeh_2484 1.66e-47 169.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2YUBZ@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_377322_1 1230343.CANP01000037_gene2740 7.84e-55 174.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,1JEHD@118969|Legionellales 118969|Legionellales J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_377322_2 1198232.CYCME_1814 8.44e-148 426.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,45ZU8@72273|Thiotrichales 72273|Thiotrichales J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_533515_1 933262.AXAM01000015_gene66 1.82e-32 121.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2WIZZ@28221|Deltaproteobacteria,2MI8E@213118|Desulfobacterales 28221|Deltaproteobacteria J Protein of unknown function (DUF933) - - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_1369479_1 1122137.AQXF01000003_gene1972 7.86e-63 216.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_325475_1 1125863.JAFN01000001_gene1438 3.36e-128 401.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_325475_2 1354722.JQLS01000001_gene4664 7.08e-10 60.8 2CK2Q@1|root,303GN@2|Bacteria,1RG44@1224|Proteobacteria,2U8BW@28211|Alphaproteobacteria,46QQN@74030|Roseovarius 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_325475_4 448385.sce5867 6.04e-45 168.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2YXZ3@29|Myxococcales 28221|Deltaproteobacteria M Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_585915_1 483219.LILAB_26095 2.49e-137 425.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2YUAS@29|Myxococcales 28221|Deltaproteobacteria P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_641383_1 519989.ECTPHS_03387 4.11e-80 252.0 COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,1RNFI@1236|Gammaproteobacteria,1X2F6@135613|Chromatiales 135613|Chromatiales E Belongs to the peptidase M17 family - - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3663,Peptidase_M17 k59_951111_1 246197.MXAN_1314 1.62e-11 60.5 2BR48@1|root,32K27@2|Bacteria,1Q2KM@1224|Proteobacteria,43878@68525|delta/epsilon subdivisions,2X3H6@28221|Deltaproteobacteria,2YW2M@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_951111_2 472759.Nhal_0414 1.83e-63 211.0 COG2433@1|root,COG2433@2|Bacteria,1QW3W@1224|Proteobacteria,1T2RV@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Pfam Transposase IS66 - - - - - - - - - - - - - k59_798401_1 1172181.KB911702_gene570 2.06e-22 98.2 COG2084@1|root,COG2084@2|Bacteria,2GTGE@201174|Actinobacteria 201174|Actinobacteria I Domain of unknown function (DUF1932) - - - - - - - - - - - - DUF1932,F420_oxidored,NAD_binding_2 k59_798401_2 1120956.JHZK01000010_gene2780 4.18e-07 50.4 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,1JN98@119043|Rhodobiaceae 28211|Alphaproteobacteria E FAD dependent oxidoreductase central domain - - 1.5.8.4 ko:K00315 ko00260,ko01100,map00260,map01100 - R01565 RC00181 ko00000,ko00001,ko01000 - - - DAO,FAO_M,GCV_T,GCV_T_C k59_1476159_1 472759.Nhal_1647 6.27e-40 138.0 COG1278@1|root,COG1278@2|Bacteria,1QW5N@1224|Proteobacteria,1T3Z1@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Sigma 54 modulation protein / S30EA ribosomal protein - - - - - - - - - - - - CSD,Ribosomal_S30AE k59_429392_1 745014.OMB55_00010940 1.1e-92 281.0 COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,1RZNC@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Alpha beta hydrolase dhaA - 3.8.1.5 ko:K01563,ko:K22318 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_115213_1 1232410.KI421418_gene2172 3.27e-46 164.0 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,42ND1@68525|delta/epsilon subdivisions,2X753@28221|Deltaproteobacteria,43VYU@69541|Desulfuromonadales 28221|Deltaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - 2.7.13.3 ko:K07642 ko02020,map02020 M00450,M00645,M00646,M00648 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_1522466_2 1123371.ATXH01000004_gene1748 1.42e-08 57.8 COG0612@1|root,COG0612@2|Bacteria,2GH66@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1056379_1 179408.Osc7112_0438 4.08e-45 161.0 COG1253@1|root,COG1253@2|Bacteria,1G16U@1117|Cyanobacteria,1H75A@1150|Oscillatoriales 1117|Cyanobacteria S PFAM CBS domain - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_1159928_1 1265756.AWZW01000008_gene711 1.52e-73 233.0 COG4177@1|root,COG4177@2|Bacteria,1MU52@1224|Proteobacteria,2TSUI@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_585935_1 631454.N177_0753 4.44e-53 170.0 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2U73D@28211|Alphaproteobacteria,1JNYC@119043|Rhodobiaceae 28211|Alphaproteobacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_585935_2 1321782.HMPREF1986_00987 7.03e-11 62.0 COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,2PRCQ@265975|Oribacterium 186801|Clostridia J Metallopeptidase family M24 map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_429400_1 1125863.JAFN01000001_gene444 5.55e-51 170.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,42N99@68525|delta/epsilon subdivisions,2WJY8@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_429400_2 555779.Dthio_PD2000 5.63e-45 156.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2WIWW@28221|Deltaproteobacteria,2M83G@213115|Desulfovibrionales 28221|Deltaproteobacteria I PFAM NAD-dependent glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_377347_1 671143.DAMO_2815 4.94e-93 299.0 COG0488@1|root,COG0488@2|Bacteria,2NNPH@2323|unclassified Bacteria 2|Bacteria S ABC transporter MA20_28645 - 3.6.3.29,3.6.3.41 ko:K06022,ko:K06158,ko:K10834 - - - - ko00000,ko01000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_1316644_1 314607.KB13_1134 5.23e-70 226.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,1KQBN@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_1316644_2 998674.ATTE01000001_gene2455 5.21e-36 133.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_1476177_1 436308.Nmar_1508 8.74e-54 171.0 COG0184@1|root,arCOG04185@2157|Archaea,41SKP@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein rps15 - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13_N,Ribosomal_S15 k59_1476177_2 1229909.NSED_08300 1.19e-24 102.0 COG0608@1|root,arCOG00427@2157|Archaea,41SZF@651137|Thaumarchaeota 651137|Thaumarchaeota L DHHA1 domain - - - ko:K07463 - - - - ko00000 - - - DHHA1 k59_641410_1 329726.AM1_2070 1.78e-29 117.0 COG0616@1|root,COG0616@2|Bacteria,1G6XQ@1117|Cyanobacteria 1117|Cyanobacteria OU Peptidase family S49 - - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_951139_1 360911.EAT1b_2850 1.82e-43 149.0 COG2065@1|root,COG2065@2|Bacteria,1V3GV@1239|Firmicutes,4HGYE@91061|Bacilli,3WE8W@539002|Bacillales incertae sedis 91061|Bacilli F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant pyrR GO:0003674,GO:0003700,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran k59_1422630_1 909663.KI867149_gene3455 1.02e-60 221.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MR7V@213462|Syntrophobacterales 28221|Deltaproteobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_272795_1 99598.Cal7507_0205 4.64e-55 180.0 COG4122@1|root,COG4122@2|Bacteria,1GIAZ@1117|Cyanobacteria,1HTFC@1161|Nostocales 1117|Cyanobacteria S O-methyltransferase activity - - - - - - - - - - - - - k59_325507_1 436308.Nmar_0072 5.05e-153 438.0 COG3276@1|root,arCOG01563@2157|Archaea,41S80@651137|Thaumarchaeota 651137|Thaumarchaeota J Initiation factor - - - ko:K03242 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - GTP_EFTU,eIF2_C k59_1159939_1 1089552.KI911559_gene2177 1.2e-109 340.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,2JREU@204441|Rhodospirillales 204441|Rhodospirillales E FAD dependent oxidoreductase - - - - - - - - - - - - DAO,FAO_M,GCV_T,GCV_T_C k59_1476194_1 314278.NB231_04395 1.05e-53 177.0 COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,1S3RM@1236|Gammaproteobacteria,1WYEW@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_433703_2 1229909.NSED_08390 1.24e-69 218.0 COG0042@1|root,arCOG00604@2157|Archaea 2157|Archaea J Dihydrouridine synthase (Dus) dusA1 - - - - - - - - - - - Dus k59_1273962_1 448385.sce1574 1.23e-84 262.0 COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,42MJ2@68525|delta/epsilon subdivisions,2WJQB@28221|Deltaproteobacteria,2YUP1@29|Myxococcales 28221|Deltaproteobacteria J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0072 IF-2B k59_696648_1 880073.Calab_2467 5.11e-92 279.0 COG1721@1|root,COG1721@2|Bacteria,2NNQI@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function DUF58 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - - - - - - - - - - DUF58 k59_696648_2 316274.Haur_4904 0.000286 42.7 COG0714@1|root,COG0714@2|Bacteria,2G85W@200795|Chloroflexi,3759A@32061|Chloroflexia 2|Bacteria S ATPase associated with various cellular activities, AAA_3 moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_224706_1 400682.PAC_15710332 2.51e-129 409.0 COG1132@1|root,KOG0055@2759|Eukaryota,39YRK@33154|Opisthokonta,3BN4Z@33208|Metazoa 33208|Metazoa Q atp-binding protein - - - - - - - - - - - - ABC_tran,oligo_HPY k59_1273972_1 330214.NIDE3293 8.45e-31 122.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,DHOR,DUF3365,FixO,PSCyt1 k59_1007837_1 411489.CLOL250_01295 7.54e-36 127.0 COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,36JIP@31979|Clostridiaceae 186801|Clostridia FG Hit family - - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_488341_1 1499967.BAYZ01000073_gene2049 1.11e-17 87.4 COG3119@1|root,COG3119@2|Bacteria,2NR0Q@2323|unclassified Bacteria 2|Bacteria P Sulfatase - - - - - - - - - - - - CBM60,Sulfatase k59_1582341_1 1589733.A0A0C5AIN0_9CAUD 1.61e-45 155.0 4QGVD@10239|Viruses,4QSSC@28883|Caudovirales,4QK2F@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_488343_1 521674.Plim_1852 7.65e-65 209.0 COG0614@1|root,COG0614@2|Bacteria,2IXWX@203682|Planctomycetes 203682|Planctomycetes P PFAM periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_382872_1 1401065.HMPREF2130_04150 3.19e-15 76.6 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2VH47@28216|Betaproteobacteria,3T2HS@506|Alcaligenaceae 28216|Betaproteobacteria E Catalyzes the formation of arginine from (N-L-arginino)succinate argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_382872_2 930169.B5T_04010 2.76e-09 58.9 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1XJDR@135619|Oceanospirillales 135619|Oceanospirillales T signal transduction protein with a C-terminal ATPase domain algZ - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase k59_1112909_1 523841.HFX_2477 2.7e-37 140.0 COG0733@1|root,arCOG04466@2157|Archaea,2XUDC@28890|Euryarchaeota,23T6P@183963|Halobacteria 183963|Halobacteria S COG0733 Na -dependent transporters of the SNF family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_955472_1 395961.Cyan7425_3868 1.96e-45 170.0 COG0155@1|root,COG0155@2|Bacteria,1G21X@1117|Cyanobacteria,3KH42@43988|Cyanothece 1117|Cyanobacteria C nitrite sulfite reductase hemoprotein beta-component ferrodoxin domain protein sir GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016002,GO:0016491,GO:0016667,GO:0016673,GO:0019419,GO:0044237,GO:0050311,GO:0055114 1.8.7.1 ko:K00392 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00859,R03600 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_433727_1 565045.NOR51B_2163 5.78e-35 135.0 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,1RNBI@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_804230_1 56780.SYN_02708 1.58e-67 227.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,42P2T@68525|delta/epsilon subdivisions,2WJ9B@28221|Deltaproteobacteria,2MRDR@213462|Syntrophobacterales 28221|Deltaproteobacteria J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA rsmB - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_804230_2 215803.DB30_5887 4.98e-91 274.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,42NC0@68525|delta/epsilon subdivisions,2WJK9@28221|Deltaproteobacteria,2YURC@29|Myxococcales 28221|Deltaproteobacteria G Belongs to the ribulose-phosphate 3-epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_1483204_2 395493.BegalDRAFT_0488 1e-134 411.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhA - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_956407_1 580332.Slit_0924 5.35e-161 481.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VJK5@28216|Betaproteobacteria 28216|Betaproteobacteria G pyruvate phosphate dikinase ppdK - 2.7.9.1,2.7.9.2 ko:K01006,ko:K01007 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173,M00374 R00199,R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_384195_1 34506.g5525 7.09e-14 72.8 COG0236@1|root,COG0304@1|root,KOG1394@2759|Eukaryota,KOG1748@2759|Eukaryota,38H9Y@33154|Opisthokonta,3BF6J@33208|Metazoa,3CYM9@33213|Bilateria,40CW1@6231|Nematoda,1KW4F@119089|Chromadorea,40RR3@6236|Rhabditida 33208|Metazoa IQ Belongs to the beta-ketoacyl-ACP synthases family - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,PP-binding,ketoacyl-synt k59_384195_3 393595.ABO_2659 3.79e-27 112.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XI69@135619|Oceanospirillales 135619|Oceanospirillales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_73814_1 1158150.KB906247_gene2335 6.91e-54 196.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1T187@1236|Gammaproteobacteria,1X254@135613|Chromatiales 135613|Chromatiales L DEAD/H associated - - - - - - - - - - - - DEAD,DEAD_assoc,Helicase_C k59_1008868_1 765911.Thivi_4205 6.24e-46 149.0 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,1S5VT@1236|Gammaproteobacteria,1WYHJ@135613|Chromatiales 135613|Chromatiales J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_1008868_2 555778.Hneap_0328 7.03e-40 136.0 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria,1WYH7@135613|Chromatiales 135613|Chromatiales J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_1008868_3 572477.Alvin_2357 6.71e-56 181.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1WVYC@135613|Chromatiales 135613|Chromatiales J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_1483219_1 1249627.D779_0428 4.17e-70 235.0 COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales 135613|Chromatiales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_805507_1 330214.NIDE0997 6.37e-149 434.0 COG0028@1|root,COG0028@2|Bacteria,3J0D6@40117|Nitrospirae 40117|Nitrospirae H Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_278371_1 394503.Ccel_2564 1.91e-28 108.0 COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,2498Z@186801|Clostridia,36DKZ@31979|Clostridiaceae 186801|Clostridia E Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC k59_278371_2 762982.HMPREF9442_00900 1.16e-11 66.2 COG0480@1|root,COG0480@2|Bacteria,4NG4H@976|Bacteroidetes,2FN1G@200643|Bacteroidia 976|Bacteroidetes J elongation factor G fusA2 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_648449_1 237368.SCABRO_01551 2.53e-71 241.0 COG3696@1|root,COG3696@2|Bacteria,2IX94@203682|Planctomycetes 203682|Planctomycetes P AcrB/AcrD/AcrF family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_905041_2 1070319.CAGGBEG34_230023 1.78e-56 187.0 COG1834@1|root,COG1834@2|Bacteria,1R545@1224|Proteobacteria,2VTWQ@28216|Betaproteobacteria,1KB7W@119060|Burkholderiaceae 28216|Betaproteobacteria E Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Amidinotransf k59_278374_1 1381123.AYOD01000035_gene3395 1.2e-42 150.0 COG1177@1|root,COG1177@2|Bacteria,1MUQD@1224|Proteobacteria,2TS3C@28211|Alphaproteobacteria,43GX4@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Binding-protein-dependent transport system inner membrane component potC - - ko:K02053 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - BPD_transp_1 k59_278374_2 331869.BAL199_20840 7.78e-11 61.6 COG1176@1|root,COG1176@2|Bacteria,1MU1Y@1224|Proteobacteria,2TTJ6@28211|Alphaproteobacteria,4BPEZ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Binding-protein-dependent transport system inner membrane component potB - - ko:K02054 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - BPD_transp_1 k59_1483232_1 436308.Nmar_0026 1.67e-34 128.0 COG1028@1|root,arCOG01259@2157|Archaea,41SXY@651137|Thaumarchaeota 651137|Thaumarchaeota I Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_330851_1 1348114.OM33_06965 1.66e-36 145.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,2Q096@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T Belongs to the PEP-utilizing enzyme family ptsP GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698 2.7.3.9 ko:K08483,ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_225725_1 187272.Mlg_0586 1.16e-47 158.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,1S3WS@1236|Gammaproteobacteria,1WYD2@135613|Chromatiales 135613|Chromatiales J binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_225725_2 717773.Thicy_0807 7.07e-19 87.8 2BFY8@1|root,329TX@2|Bacteria,1R582@1224|Proteobacteria,1RY97@1236|Gammaproteobacteria,46129@72273|Thiotrichales 72273|Thiotrichales S membrane - - - - - - - - - - - - DUF2232 k59_1275359_1 445686.E3SL89_9CAUD 2.93e-07 50.8 4QAR1@10239|Viruses,4QUNA@35237|dsDNA viruses no RNA stage,4QPJE@28883|Caudovirales,4QI9Y@10662|Myoviridae 10662|Myoviridae S ATPase family associated with various cellular activities (AAA) - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_1275359_3 59931.WH7805_00690 1.89e-37 132.0 2AF50@1|root,3153R@2|Bacteria,1G6TP@1117|Cyanobacteria,1H22W@1129|Synechococcus 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_956436_1 1125863.JAFN01000001_gene1551 3.51e-06 45.4 COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42T3M@68525|delta/epsilon subdivisions,2WPVI@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - FlpD k59_956436_2 706587.Desti_5031 5.13e-28 115.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,Pyr_redox_2 k59_1275362_1 639282.DEFDS_1228 1.14e-08 55.1 COG4799@1|root,COG4799@2|Bacteria,2GEP0@200930|Deferribacteres 200930|Deferribacteres I Carboxyl transferase domain - - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1275362_2 1192034.CAP_3380 6.73e-51 176.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria,2YUGB@29|Myxococcales 28221|Deltaproteobacteria I Biotin carboxylase C-terminal domain pccA - 6.3.4.14,6.3.4.6,6.4.1.2 ko:K01941,ko:K01961 ko00061,ko00220,ko00620,ko00640,ko00720,ko00791,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00220,map00620,map00640,map00720,map00791,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R00774,R04385 RC00040,RC00253,RC00367,RC00378 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_1526131_1 335283.Neut_0703 5.88e-139 417.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,3724V@32003|Nitrosomonadales 28216|Betaproteobacteria I acyl-CoA dehydrogenase fadE - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_805547_2 1121382.JQKG01000005_gene3364 2.06e-80 251.0 COG4992@1|root,COG4992@2|Bacteria,1WIII@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family argD - 2.6.1.13,2.6.1.82 ko:K00819,ko:K09251 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R00667,R01155 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_1164233_1 266835.14023171 4.54e-100 310.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,43HRF@69277|Phyllobacteriaceae 28211|Alphaproteobacteria V ABC-type multidrug transport system ATPase and permease abcT3 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702 - ko:K06147,ko:K18893 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_905069_1 1123371.ATXH01000004_gene1761 4.69e-77 240.0 COG1191@1|root,COG1191@2|Bacteria,2GHGC@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria K Sigma-70, region 4 - - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_648492_1 760192.Halhy_0886 5.74e-92 297.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,1IWHI@117747|Sphingobacteriia 976|Bacteroidetes M Tricorn protease PDZ domain - - - ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ k59_1429551_1 521460.Athe_0633 4.56e-66 209.0 COG0035@1|root,COG0035@2|Bacteria,1TPMT@1239|Firmicutes,248FV@186801|Clostridia,42FSE@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate upp - 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000 - - - UPRTase k59_538772_1 570967.JMLV01000009_gene1011 2.22e-92 290.0 COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,2JQ6J@204441|Rhodospirillales 204441|Rhodospirillales E COG4166 ABC-type oligopeptide transport system, periplasmic component - - - ko:K13893 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 k59_1275382_2 572477.Alvin_2007 1.08e-59 196.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1WW8H@135613|Chromatiales 135613|Chromatiales I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_1164238_1 316067.Geob_2508 5.7e-72 229.0 COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,42MC3@68525|delta/epsilon subdivisions,2WK3M@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C k59_278408_1 1121033.AUCF01000011_gene1713 4e-43 145.0 COG4564@1|root,COG4564@2|Bacteria,1RFW5@1224|Proteobacteria,2U8YZ@28211|Alphaproteobacteria,2JWMQ@204441|Rhodospirillales 204441|Rhodospirillales T Cache domain - - - - - - - - - - - - sCache_2 k59_1320654_2 187303.BN69_3618 8.31e-33 126.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2TS5I@28211|Alphaproteobacteria,36XJ9@31993|Methylocystaceae 28211|Alphaproteobacteria S Peptidogalycan biosysnthesis/recognition MA20_36195 - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_73879_2 991905.SL003B_1271 1.5e-18 83.2 COG1586@1|root,COG1586@2|Bacteria,1RH88@1224|Proteobacteria,2U5D3@28211|Alphaproteobacteria,4BSD4@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speH - 2.5.1.16,4.1.1.50 ko:K00797,ko:K01611 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R00178,R01920,R02869,R08359 RC00021,RC00053,RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc,Spermine_synt_N,Spermine_synth k59_330890_1 1123320.KB889697_gene8992 4.46e-27 103.0 COG0748@1|root,COG0748@2|Bacteria,2IM1N@201174|Actinobacteria 201174|Actinobacteria P F420H(2)-dependent quinone reductase - - - - - - - - - - - - F420H2_quin_red k59_330890_2 247634.GPB2148_1167 4.5e-20 87.8 COG1028@1|root,COG1028@2|Bacteria,1MWSK@1224|Proteobacteria,1RN19@1236|Gammaproteobacteria,1J4SV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_1429581_1 1177928.TH2_14169 6.77e-72 227.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria,2JPP5@204441|Rhodospirillales 204441|Rhodospirillales Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_747820_1 330214.NIDE4024 9.12e-125 365.0 COG1104@1|root,COG1104@2|Bacteria,3J0AX@40117|Nitrospirae 40117|Nitrospirae E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_905099_2 1123253.AUBD01000008_gene323 0.000761 42.7 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1X3E5@135614|Xanthomonadales 135614|Xanthomonadales O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_171332_1 511062.GU3_09825 1.92e-56 187.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1Y3ZJ@135624|Aeromonadales 135624|Aeromonadales J Responsible for synthesis of pseudouridine from uracil - - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_747828_1 1120934.KB894404_gene599 5.41e-32 128.0 COG3850@1|root,COG3850@2|Bacteria,2GIWI@201174|Actinobacteria,4DZEN@85010|Pseudonocardiales 201174|Actinobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HATPase_c_2,HisKA_3 k59_1374810_1 443143.GM18_2525 1.85e-25 108.0 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,42NEZ@68525|delta/epsilon subdivisions,2WJ5R@28221|Deltaproteobacteria,43U4X@69541|Desulfuromonadales 28221|Deltaproteobacteria S AAA domain - - - ko:K07028 - - - - ko00000 - - - AAA_33,APH k59_1483308_1 307480.IW16_09375 2.36e-38 147.0 COG1009@1|root,COG1009@2|Bacteria,4NEBM@976|Bacteroidetes,1HWXX@117743|Flavobacteriia,3ZPD7@59732|Chryseobacterium 976|Bacteroidetes CP NADH ubiquinone oxidoreductase subunit L nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_852688_1 196490.AUEZ01000118_gene2864 6.09e-62 208.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2TW1M@28211|Alphaproteobacteria,3K6SV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_1526167_2 91464.S7335_1907 7.72e-15 74.3 COG1943@1|root,COG1943@2|Bacteria,1G9J6@1117|Cyanobacteria,1H3MP@1129|Synechococcus 1117|Cyanobacteria L Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_2 k59_231473_1 1218076.BAYB01000026_gene4437 7.65e-06 48.1 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VM5X@28216|Betaproteobacteria,1K3FG@119060|Burkholderiaceae 28216|Betaproteobacteria C CoA-transferase family III - - 2.8.3.19 ko:K18702 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_231473_2 1123024.AUII01000004_gene1474 5.59e-33 127.0 COG2267@1|root,COG2267@2|Bacteria,2IBJN@201174|Actinobacteria,4EF72@85010|Pseudonocardiales 201174|Actinobacteria I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1437468_1 237609.PSAKL28_25330 5.63e-41 149.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,1RRHA@1236|Gammaproteobacteria 1236|Gammaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_497795_1 35128.Thapsdraft1319 1.22e-101 298.0 COG0396@1|root,2QS88@2759|Eukaryota,2XFH5@2836|Bacillariophyta 2836|Bacillariophyta Q ABC transporter - - - - - - - - - - - - ABC_tran k59_231480_1 638303.Thal_0771 4.38e-25 107.0 COG0475@1|root,COG0475@2|Bacteria 2|Bacteria P glutathione-regulated potassium exporter activity napA2 - - - - - - - - - - - Na_H_Exchanger,PTS_EIIA_2 k59_597263_1 59374.Fisuc_0110 2.16e-15 80.1 COG4239@1|root,COG4239@2|Bacteria 2|Bacteria P microcin transport yejE - - ko:K13895 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - BPD_transp_1,OppC_N k59_1491251_2 754476.Q7A_2836 2.34e-102 306.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,4602K@72273|Thiotrichales 72273|Thiotrichales D TIGRFAM Cell shape determining protein MreB Mrl - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_1380426_1 1521187.JPIM01000020_gene212 4.21e-112 341.0 COG0415@1|root,COG0415@2|Bacteria,2G5WD@200795|Chloroflexi,375BT@32061|Chloroflexia 32061|Chloroflexia L PFAM DNA photolyase, FAD-binding - - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_1380426_2 330214.NIDE0204 5.82e-125 367.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,3J13F@40117|Nitrospirae 40117|Nitrospirae S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_1380426_3 72558.CBQ70208 3.86e-05 46.2 COG1231@1|root,KOG0029@2759|Eukaryota,38B4W@33154|Opisthokonta,3P0FD@4751|Fungi,3V5Y3@5204|Basidiomycota,3MZB9@452284|Ustilaginomycotina 4751|Fungi Q Flavin containing amine oxidoreductase - - 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_1325077_1 694427.Palpr_2933 1.77e-33 122.0 COG1845@1|root,COG1845@2|Bacteria,4NDYG@976|Bacteroidetes,2FXG8@200643|Bacteroidia 976|Bacteroidetes C cytochrome c oxidase subunit III coxP - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_1325077_2 1267535.KB906767_gene1092 1.86e-69 228.0 COG0843@1|root,COG0843@2|Bacteria,3Y2X6@57723|Acidobacteria,2JIRX@204432|Acidobacteriia 204432|Acidobacteriia C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_597266_1 575589.HMPREF0018_02795 5.25e-13 68.9 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,3NJ8G@468|Moraxellaceae 1236|Gammaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641 DFP,Flavoprotein k59_597266_2 278957.ABEA03000041_gene2139 2e-10 61.2 COG0129@1|root,COG0129@2|Bacteria,46SBY@74201|Verrucomicrobia,3K7M4@414999|Opitutae 414999|Opitutae EG Dehydratase family - - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_813687_1 472759.Nhal_1304 1.03e-74 235.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,1RNNI@1236|Gammaproteobacteria,1WZI5@135613|Chromatiales 135613|Chromatiales H Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily phnW - 2.6.1.37 ko:K03430 ko00440,ko01100,ko01120,map00440,map01100,map01120 - R04152 RC00008,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_5 k59_1228154_1 1121106.JQKB01000008_gene1460 1.38e-06 55.8 COG0665@1|root,COG0665@2|Bacteria,1MU7M@1224|Proteobacteria,2TT69@28211|Alphaproteobacteria,2JR5D@204441|Rhodospirillales 204441|Rhodospirillales E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_336713_2 1089553.Tph_c09730 9.57e-10 60.8 COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,42F45@68295|Thermoanaerobacterales 186801|Clostridia S conserved protein UCP033563 - - - - - - - - - - - - DUF1015 k59_656624_2 448385.sce0250 5.52e-46 158.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,42QPM@68525|delta/epsilon subdivisions,2WMRG@28221|Deltaproteobacteria,2YWMX@29|Myxococcales 28221|Deltaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - iAF987.Gmet_1716 ECH_1 k59_81925_1 1123354.AUDR01000012_gene1840 1.17e-100 311.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2VIGG@28216|Betaproteobacteria,1KS0D@119069|Hydrogenophilales 119069|Hydrogenophilales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_813692_1 1123368.AUIS01000037_gene22 2.41e-15 74.7 COG2960@1|root,COG2960@2|Bacteria,1NJYD@1224|Proteobacteria,1RYI7@1236|Gammaproteobacteria 1236|Gammaproteobacteria M long-chain fatty acid transporting porin activity - - - - - - - - - - - - - k59_813692_2 1046724.KB889923_gene1409 2.08e-28 105.0 COG2010@1|root,COG2010@2|Bacteria,1RFJV@1224|Proteobacteria,1S4GY@1236|Gammaproteobacteria,46905@72275|Alteromonadaceae 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_390665_1 502025.Hoch_5653 2.58e-80 246.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42NY7@68525|delta/epsilon subdivisions,2WIXK@28221|Deltaproteobacteria,2Z364@29|Myxococcales 28221|Deltaproteobacteria L Endonuclease/Exonuclease/phosphatase family - - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_1437503_1 1210884.HG799475_gene15269 2.09e-115 347.0 COG0033@1|root,COG0033@2|Bacteria,2IYG0@203682|Planctomycetes 203682|Planctomycetes G Phosphoglucomutase/phosphomannomutase, C-terminal domain - - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_390673_1 391625.PPSIR1_08511 8.93e-48 171.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_441885_1 1214242.B446_08145 3.59e-90 290.0 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - ko:K06147,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1168735_1 497321.C664_14454 1.41e-32 121.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2WEFP@28216|Betaproteobacteria,2M03Q@206389|Rhodocyclales 206389|Rhodocyclales K Alginate biosynthesis regulatory protein AlgR - - - ko:K08083 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_1228198_1 694440.JOMF01000005_gene259 1.98e-05 52.8 COG0624@1|root,arCOG01107@2157|Archaea,2XU86@28890|Euryarchaeota,2NB5W@224756|Methanomicrobia 224756|Methanomicrobia E peptidase dimerisation domain argE - 3.5.1.16,3.5.1.18 ko:K01438,ko:K01439 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R00669,R02734,R09107 RC00064,RC00090,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_1283692_1 1500894.JQNN01000001_gene1763 5.97e-24 105.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,472M9@75682|Oxalobacteraceae 28216|Betaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_390681_1 1229909.NSED_06205 2.08e-26 99.8 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_390681_2 436308.Nmar_1060 1.54e-12 65.1 arCOG10572@1|root,arCOG10572@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_497857_1 1229909.NSED_07310 2.25e-105 327.0 COG1205@1|root,arCOG08693@1|root,arCOG00555@2157|Archaea,arCOG08693@2157|Archaea,41SZS@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD DEAH box helicase - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C k59_911211_1 279714.FuraDRAFT_3772 7.14e-49 165.0 COG0438@1|root,COG0438@2|Bacteria,1R4Q9@1224|Proteobacteria 1224|Proteobacteria M Glycosyl transferase group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glycos_transf_1 k59_1119837_1 1056820.KB900674_gene2506 7.67e-107 321.0 COG3517@1|root,COG3517@2|Bacteria,1MU5C@1224|Proteobacteria,1RNP7@1236|Gammaproteobacteria,2PQ0I@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Type VI secretion protein, EvpB/VC_A0108, tail sheath impC - - ko:K11900 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - VipB k59_1228213_1 1232410.KI421415_gene2933 2.8e-90 297.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_10675_2 1462527.CCDM010000001_gene2878 1.17e-29 120.0 COG5146@1|root,COG5146@2|Bacteria,1V2R2@1239|Firmicutes,4HG04@91061|Bacilli,23K5X@182709|Oceanobacillus 91061|Bacilli F Fumble coaW - 2.7.1.33 ko:K09680 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Fumble k59_10675_3 1167006.UWK_00481 3.86e-23 97.1 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42N7S@68525|delta/epsilon subdivisions,2WMBC@28221|Deltaproteobacteria,2MIMN@213118|Desulfobacterales 28221|Deltaproteobacteria U PFAM Peptidoglycan-binding domain 1 protein - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_911215_1 649638.Trad_0121 1.26e-160 464.0 COG0160@1|root,COG0160@2|Bacteria,1WJ8V@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.19,2.6.1.22 ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1644502_1 1026882.MAMP_01556 2.36e-80 241.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,460IN@72273|Thiotrichales 72273|Thiotrichales F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_1589630_1 396588.Tgr7_0968 8.87e-79 256.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales 135613|Chromatiales L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_336771_1 497321.C664_00175 3.91e-06 47.8 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,2KV3S@206389|Rhodocyclales 206389|Rhodocyclales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1437556_1 502025.Hoch_2213 2.62e-15 78.6 COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R2NF@1224|Proteobacteria,43AJU@68525|delta/epsilon subdivisions,2X600@28221|Deltaproteobacteria 28221|Deltaproteobacteria K helix_turn_helix, mercury resistance - - - ko:K22491 - - - - ko00000,ko03000 - - - B12-binding,MerR_1 k59_1437556_2 932213.SPM24T3_11245 1.91e-08 60.8 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,401WT@613|Serratia 1236|Gammaproteobacteria L Belongs to the DNA photolyase family phrB GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0006139,GO:0006259,GO:0006281,GO:0006464,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0018298,GO:0019538,GO:0033554,GO:0034641,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901564 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_497887_1 2340.JV46_14060 9.88e-65 212.0 COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,1RS2Z@1236|Gammaproteobacteria,1J92V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Amidase - - - - - - - - - - - - Amidase k59_497887_3 1380394.JADL01000002_gene1085 3.4e-08 54.3 COG0179@1|root,COG1893@1|root,COG0179@2|Bacteria,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,2JR4P@204441|Rhodospirillales 28211|Alphaproteobacteria H Ketopantoate reductase PanE/ApbA C terminal panE - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C,DUF2437,FAA_hydrolase k59_1067968_1 419665.Maeo_0402 4.63e-43 147.0 COG0279@1|root,arCOG05355@2157|Archaea,2XUSN@28890|Euryarchaeota,23QH1@183939|Methanococci 183939|Methanococci G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 k59_1067968_2 1232410.KI421414_gene2901 3.51e-06 48.1 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,42MFX@68525|delta/epsilon subdivisions,2WJ91@28221|Deltaproteobacteria,43T6C@69541|Desulfuromonadales 28221|Deltaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_1644516_1 90814.KL370891_gene371 3.15e-49 160.0 COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1S8TB@1236|Gammaproteobacteria,460YN@72273|Thiotrichales 72273|Thiotrichales S Protein of unknown function (DUF971) - - - - - - - - - - - - DUF971 k59_1644516_2 1123261.AXDW01000002_gene1543 2.41e-89 271.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1X4GY@135614|Xanthomonadales 135614|Xanthomonadales H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_1228243_1 1004785.AMBLS11_10000 2.41e-33 132.0 2CIG2@1|root,2Z80B@2|Bacteria,1R4V1@1224|Proteobacteria,1RS80@1236|Gammaproteobacteria,465UI@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_231555_1 1131553.JIBI01000045_gene1571 3.35e-70 237.0 COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2WEJA@28216|Betaproteobacteria,374P7@32003|Nitrosomonadales 28216|Betaproteobacteria EO pdz dhr glgf - - - - - - - - - - - - PDZ_2,Peptidase_M1,Peptidase_M28 k59_441939_1 1232410.KI421426_gene1403 3.27e-96 287.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,42NC0@68525|delta/epsilon subdivisions,2WJK9@28221|Deltaproteobacteria,43TEV@69541|Desulfuromonadales 28221|Deltaproteobacteria G Ribulose-phosphate 3 epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_82019_1 396588.Tgr7_2292 1.7e-118 352.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1WWN1@135613|Chromatiales 135613|Chromatiales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_813783_2 518766.Rmar_2362 5.24e-16 78.6 COG1215@1|root,COG1215@2|Bacteria,4NH18@976|Bacteroidetes,1FJVU@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Glycosyl transferase family 21 - - - ko:K00786 - - - - ko00000,ko01000 - - - Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,Sulfatase k59_1589651_1 1247963.JPHU01000009_gene2414 2.58e-11 68.9 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_441948_1 1255043.TVNIR_3568 1.33e-130 401.0 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1WW7J@135613|Chromatiales 135613|Chromatiales F Ribonucleotide reductase, barrel domain - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1228259_2 861299.J421_2744 6.11e-06 49.7 29W2Z@1|root,30HMM@2|Bacteria,1ZTXQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - k59_1283754_1 351348.Maqu_3230 2.26e-23 105.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,469ZG@72275|Alteromonadaceae 1236|Gammaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_497919_2 1173024.KI912152_gene366 5.71e-68 219.0 COG3119@1|root,COG3119@2|Bacteria,1G3EC@1117|Cyanobacteria 1117|Cyanobacteria P Arylsulfatase a - - - - - - - - - - - - Sulfatase k59_1283769_1 330214.NIDE4049 3.05e-59 187.0 2BXN6@1|root,2ZK04@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_231578_1 1502852.FG94_00254 2.21e-74 239.0 COG0665@1|root,COG0665@2|Bacteria,1MU40@1224|Proteobacteria,2VSIK@28216|Betaproteobacteria,475HS@75682|Oxalobacteraceae 28216|Betaproteobacteria E Tryptophan halogenase - - - - - - - - - - - - Trp_halogenase k59_1169734_1 396588.Tgr7_2051 1.07e-124 367.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1WWD4@135613|Chromatiales 135613|Chromatiales J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_1169734_2 754476.Q7A_2562 1.91e-07 54.7 COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria,460N9@72273|Thiotrichales 72273|Thiotrichales NU TIGRFAM type IV pilus biogenesis stability protein PilW - - - ko:K02656 - - - - ko00000,ko02035,ko02044 - - - TPR_2,TPR_8 k59_499465_1 1117647.M5M_13590 2.29e-93 295.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria,1J8XH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_1169742_1 582744.Msip34_2284 1.31e-44 155.0 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2VPZQ@28216|Betaproteobacteria 28216|Betaproteobacteria L uracil-DNA glycosylase dpo - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1169742_2 1283300.ATXB01000001_gene1847 1.12e-44 151.0 COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,1XEY7@135618|Methylococcales 135618|Methylococcales K Ribosomal-protein-alanine acetyltransferase rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_1229753_1 1078020.KEK_08897 2.65e-37 136.0 COG3804@1|root,COG3804@2|Bacteria,2I8CX@201174|Actinobacteria,2330G@1762|Mycobacteriaceae 201174|Actinobacteria S dihydrodipicolinate reductase dapB_1 - - - - - - - - - - - DapB_N k59_1502611_2 998088.B565_0862 6.2e-18 82.4 COG1090@1|root,COG1090@2|Bacteria,1MUB4@1224|Proteobacteria,1RN6A@1236|Gammaproteobacteria,1Y3RR@135624|Aeromonadales 135624|Aeromonadales S Domain of unknown function (DUF1731) - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase k59_92864_1 247634.GPB2148_595 9.4e-46 154.0 COG0667@1|root,COG0667@2|Bacteria,1PDY4@1224|Proteobacteria,1RQYV@1236|Gammaproteobacteria,1J64N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C oxidoreductases (related to aryl-alcohol dehydrogenases) - - - - - - - - - - - - Aldo_ket_red k59_605025_2 429009.Adeg_0312 3.74e-51 176.0 COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,42FB3@68295|Thermoanaerobacterales 186801|Clostridia F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_668148_1 1122994.AUFR01000031_gene590 1.27e-137 429.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1149@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1149@2|Bacteria,2I995@201174|Actinobacteria,4DVUV@85009|Propionibacteriales 201174|Actinobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K00169,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1295098_1 1089552.KI911559_gene1733 3.37e-56 191.0 COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,2JQU6@204441|Rhodospirillales 204441|Rhodospirillales J COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - - - - - - - - - - - Amidase k59_139464_1 314345.SPV1_06634 5.31e-80 243.0 28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF4126) - - - - - - - - - - - - DUF4126 k59_452499_1 765914.ThisiDRAFT_0262 4.06e-16 77.8 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1WWPY@135613|Chromatiales 135613|Chromatiales I TIGRFAM acetyl-CoA carboxylase, biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_452499_2 1121939.L861_18515 0.000742 43.1 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1XHE4@135619|Oceanospirillales 135619|Oceanospirillales J Ribosomal protein L11 methyltransferase prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_452505_1 321332.CYB_1511 2.47e-101 305.0 COG0082@1|root,COG0082@2|Bacteria,1G12S@1117|Cyanobacteria,1GYWY@1129|Synechococcus 1117|Cyanobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - iJN678.aroC Chorismate_synt k59_139472_1 396588.Tgr7_2195 2.59e-73 226.0 COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,1RRYZ@1236|Gammaproteobacteria,1WVZM@135613|Chromatiales 135613|Chromatiales C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11,Fer4_7 k59_970513_1 83406.HDN1F_23220 1.24e-66 212.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1J4SJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - iSbBS512_1146.SbBS512_E0035 DapB_C,DapB_N k59_970513_2 62928.azo1062 3.22e-37 135.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,2KUWF@206389|Rhodocyclales 206389|Rhodocyclales O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_761751_1 859653.HIMB5_00008920 9.19e-28 111.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,4BPQB@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the GcvT family dmgdh2 - 1.5.8.4 ko:K00315 ko00260,ko01100,map00260,map01100 - R01565 RC00181 ko00000,ko00001,ko01000 - - - DAO,FAO_M,GCV_T,GCV_T_C k59_761751_2 1380391.JIAS01000002_gene3117 2.52e-43 146.0 COG4341@1|root,COG4341@2|Bacteria,1QHQD@1224|Proteobacteria,2U0VM@28211|Alphaproteobacteria,2JT5P@204441|Rhodospirillales 204441|Rhodospirillales S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD k59_1129942_1 105559.Nwat_0686 5.17e-65 210.0 COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,1WXIP@135613|Chromatiales 135613|Chromatiales E Belongs to the agmatine deiminase family aguA - - - - - - - - - - - PAD_porph k59_1446503_1 402881.Plav_3070 4.62e-22 94.4 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria,1JP48@119043|Rhodobiaceae 28211|Alphaproteobacteria I Thiolase, N-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1446503_2 864051.BurJ1DRAFT_1621 3.25e-35 126.0 COG0406@1|root,COG0406@2|Bacteria,1N83T@1224|Proteobacteria,2VY3M@28216|Betaproteobacteria 28216|Betaproteobacteria G PFAM Phosphoglycerate mutase - - - - - - - - - - - - His_Phos_1 k59_182921_1 1349822.NSB1T_14395 2.12e-44 166.0 COG1472@1|root,COG1680@1|root,COG1472@2|Bacteria,COG1680@2|Bacteria,4NET8@976|Bacteroidetes,2FN0V@200643|Bacteroidia,22WIJ@171551|Porphyromonadaceae 976|Bacteroidetes G hydrolase, family 3 nagA - - - - - - - - - - - Beta-lactamase,Glyco_hydro_3,Glyco_hydro_3_C k59_711948_1 1254432.SCE1572_04370 1.5e-117 358.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42NDG@68525|delta/epsilon subdivisions,2WKYU@28221|Deltaproteobacteria,2YTWT@29|Myxococcales 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1656008_1 745014.OMB55_00018660 5.82e-23 92.0 COG2827@1|root,COG2827@2|Bacteria 2|Bacteria L Endonuclease containing a URI domain yhbQ GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07461 - - - - ko00000 - - - GIY-YIG k59_1295142_1 99598.Cal7507_3161 3.52e-64 215.0 COG0365@1|root,COG0365@2|Bacteria,1G0E7@1117|Cyanobacteria,1HM2H@1161|Nostocales 1117|Cyanobacteria H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_866875_1 977880.RALTA_B1912 5.06e-46 166.0 COG0607@1|root,COG2897@1|root,COG5553@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria,COG5553@2|Bacteria,1MU3V@1224|Proteobacteria,2VH3U@28216|Betaproteobacteria,1K1TG@119060|Burkholderiaceae 28216|Betaproteobacteria P PFAM Rhodanese domain protein - - - - - - - - - - - - Rhodanese k59_1238735_1 159749.E7BWK6 3.69e-85 264.0 COG0464@1|root,KOG0730@2759|Eukaryota 2759|Eukaryota O ATP binding ycf46 - - - - - - - - - - - AAA k59_1238735_2 159749.E7BWK5 1.78e-11 63.5 COG1333@1|root,2QRFF@2759|Eukaryota 2759|Eukaryota O cytochrome complex assembly ccs1 - - ko:K07399 - - - - ko00000 - - - ResB k59_1502690_1 1229205.BUPH_03002 3.84e-61 210.0 COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,2VJ4I@28216|Betaproteobacteria,1K1BW@119060|Burkholderiaceae 28216|Betaproteobacteria I Glycerol acyltransferase aas - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - Acyltransferase,MFS_1 k59_970543_1 472759.Nhal_2432 5.03e-118 345.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1WW3F@135613|Chromatiales 135613|Chromatiales S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_970543_2 454957.IA64_11300 6.81e-15 72.8 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1X3XJ@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_761780_1 83406.HDN1F_20090 2.11e-41 155.0 COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,1T2GI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.7.5.1,1.8.5.3 ko:K00370,ko:K07306,ko:K17050 ko00910,ko00920,ko01120,ko02020,map00910,map00920,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497,R09501 RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.3,5.A.3.8 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_294310_1 436308.Nmar_1008 3.57e-50 179.0 COG0458@1|root,COG0624@1|root,arCOG01107@2157|Archaea,arCOG01596@2157|Archaea 2157|Archaea EF ATP-grasp domain cxp2 - 3.4.17.11,3.5.1.18,6.3.2.4 ko:K01295,ko:K01439,ko:K01921,ko:K16181 ko00300,ko00473,ko00550,ko01100,ko01120,ko01230,ko01502,map00300,map00473,map00550,map01100,map01120,map01230,map01502 M00016 R01150,R02734,R10011 RC00064,RC00090,RC00096,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011 - - - ATP-grasp_3,CPSase_L_D2,Dala_Dala_lig_C,M20_dimer,Peptidase_M20 k59_92945_1 1160137.KB907307_gene3379 2.43e-60 202.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FU9T@85025|Nocardiaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.41 ko:K18687 ko00984,ko01100,ko01120,map00984,map01100,map01120 - R10769 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_1176305_1 515618.RIEPE_0058 6.86e-24 92.0 COG1551@1|root,COG1551@2|Bacteria,1N6PG@1224|Proteobacteria,1SCB4@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005979,GO:0006109,GO:0006139,GO:0006417,GO:0006446,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0010675,GO:0010677,GO:0010906,GO:0010962,GO:0016070,GO:0016071,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032881,GO:0032885,GO:0034248,GO:0034249,GO:0034641,GO:0043170,GO:0043255,GO:0043467,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045719,GO:0045912,GO:0045947,GO:0046483,GO:0048027,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0062012,GO:0065007,GO:0070873,GO:0070874,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:2000112,GO:2000113 - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k59_14855_1 330214.NIDE0836 2.13e-106 327.0 COG1048@1|root,COG1048@2|Bacteria,3J0E6@40117|Nitrospirae 40117|Nitrospirae C Aconitase C-terminal domain - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1597485_1 331869.BAL199_21289 2.96e-18 84.7 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2UE45@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Tpr repeat-containing protein - - - - - - - - - - - - 2OG-FeII_Oxy_5,TPR_16,TPR_19 k59_1295174_1 1121403.AUCV01000013_gene3901 9.9e-54 178.0 COG0765@1|root,COG0765@2|Bacteria,1R4RU@1224|Proteobacteria,42PW7@68525|delta/epsilon subdivisions,2WK9J@28221|Deltaproteobacteria,2MJID@213118|Desulfobacterales 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02029 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 k59_1387958_1 1397693.KK211187_gene2900 3.34e-07 59.3 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,3WF7S@539002|Bacillales incertae sedis 91061|Bacilli NT histidine kinase HAMP region domain protein cheW5 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,dCache_1 k59_139537_1 392500.Swoo_2899 3.49e-35 130.0 COG3137@1|root,COG3137@2|Bacteria,1RCKQ@1224|Proteobacteria,1S0GK@1236|Gammaproteobacteria,2QA2B@267890|Shewanellaceae 1236|Gammaproteobacteria M Protein of unknown function, DUF481 - - - - - - - - - - - - DUF481 k59_510773_1 479432.Sros_0655 1.49e-69 225.0 COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria,4EN0U@85012|Streptosporangiales 201174|Actinobacteria M UDP binding domain algD - 1.1.1.132 ko:K00066 ko00051,ko00520,ko02020,map00051,map00520,map02020 - R00880 RC00291 ko00000,ko00001,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_605949_1 1205680.CAKO01000002_gene2546 3.98e-25 106.0 COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2TRXY@28211|Alphaproteobacteria 28211|Alphaproteobacteria P PFAM amidohydrolase MA20_19310 - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_826731_1 765910.MARPU_08930 0.000239 48.9 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1WWPB@135613|Chromatiales 135613|Chromatiales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,Response_reg,dCache_3 k59_826733_1 1120965.AUBV01000001_gene3166 2.89e-06 55.1 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,47QEI@768503|Cytophagia 976|Bacteroidetes K COGs COG5616 integral membrane protein - - - - - - - - - - - - Guanylate_cyc,TPR_17,TPR_8 k59_15707_1 1379698.RBG1_1C00001G1061 1.03e-39 147.0 COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria 2|Bacteria C NADH-quinone oxidoreductase, chain M nuoM-1 - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_15715_1 35754.JNYJ01000038_gene5060 3.18e-13 69.7 COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,4D9HB@85008|Micromonosporales 201174|Actinobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_347813_1 765911.Thivi_1869 5.03e-151 438.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1WWNU@135613|Chromatiales 135613|Chromatiales E PFAM Aminotransferase class-III argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_398930_1 1177181.T9A_00077 4.6e-81 256.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1XHAH@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,Pribosyltran k59_295695_1 675635.Psed_4593 1.37e-64 216.0 COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4DZFB@85010|Pseudonocardiales 201174|Actinobacteria C Fumarate reductase flavoprotein C-term sdhA - 1.3.5.1,1.3.5.4,1.4.3.16 ko:K00239,ko:K00278 ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00115,M00149,M00173,M00374,M00376 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1177324_1 359.CN09_18745 2.51e-132 382.0 COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,4BDDJ@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_669584_1 1283300.ATXB01000001_gene807 7.75e-33 130.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1XDNX@135618|Methylococcales 135618|Methylococcales CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_713047_1 2340.JV46_14290 9.97e-73 236.0 COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit - - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_922792_2 436308.Nmar_0060 2.23e-32 121.0 COG1794@1|root,arCOG02005@2157|Archaea,41SM4@651137|Thaumarchaeota 651137|Thaumarchaeota M Asp/Glu/Hydantoin racemase - - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_183893_1 1487956.DR71_1826 4.96e-06 50.8 COG1826@1|root,COG1826@2|Bacteria,2HJ5I@201174|Actinobacteria,22NI9@1653|Corynebacteriaceae 201174|Actinobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation tatB - - ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_183893_2 697282.Mettu_1669 6.25e-09 53.9 COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,1XFSS@135618|Methylococcales 135618|Methylococcales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA GO:0002790,GO:0003674,GO:0005215,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705 - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_94385_1 323848.Nmul_A2541 2.39e-92 281.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,37280@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_1388967_1 1317118.ATO8_18175 8.79e-119 354.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG4584 Transposase and inactivated derivatives - - - - - - - - - - - - rve k59_762664_1 1122137.AQXF01000002_gene283 1.51e-43 152.0 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria 28211|Alphaproteobacteria L NADP-dependent oxidoreductase - - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N k59_140663_1 187272.Mlg_2467 9.95e-43 166.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,1X0N1@135613|Chromatiales 135613|Chromatiales S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1239923_2 1078020.KEK_14003 1.26e-06 53.5 COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria,232PI@1762|Mycobacteriaceae 201174|Actinobacteria Q cytochrome p450 cyp51 GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0008398,GO:0016125,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0032451,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046906,GO:0048037,GO:0055114,GO:0070988,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901615 1.14.13.70 ko:K05917 ko00100,ko01100,ko01110,ko01130,map00100,map01100,map01110,map01130 M00101 R05640,R05731 RC01442 ko00000,ko00001,ko00002,ko00199,ko01000 - - - p450 k59_94399_1 272568.GDI2647 1.65e-41 153.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,2JPIQ@204441|Rhodospirillales 204441|Rhodospirillales O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1388977_1 2340.JV46_13050 1.28e-69 220.0 COG1014@1|root,COG1144@1|root,COG1014@2|Bacteria,COG1144@2|Bacteria,1N12F@1224|Proteobacteria,1S7UK@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate - - 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR k59_867761_1 445686.E3SL64_9CAUD 8.05e-10 58.5 4QAWI@10239|Viruses,4QW40@35237|dsDNA viruses no RNA stage,4QPUX@28883|Caudovirales,4QINW@10662|Myoviridae 10662|Myoviridae S Pfam:Peptidase_S77 - - - - - - - - - - - - - k59_15750_1 471881.PROPEN_00115 9.14e-11 63.9 COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,1RMMR@1236|Gammaproteobacteria,3Z1ZJ@583|Proteus 1236|Gammaproteobacteria P N-terminal TM domain of oligopeptide transport permease C yddQ - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_15754_2 1458357.BG58_05425 1.01e-41 152.0 COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2VN65@28216|Betaproteobacteria,1K3BE@119060|Burkholderiaceae 28216|Betaproteobacteria S MmgE/PrpD family - - - - - - - - - - - - MmgE_PrpD k59_510845_1 338963.Pcar_0323 4.62e-37 139.0 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,42N0J@68525|delta/epsilon subdivisions,2WJFX@28221|Deltaproteobacteria,43S7G@69541|Desulfuromonadales 28221|Deltaproteobacteria J 3'-5' exonuclease rnd - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_1333538_1 330214.NIDE0595 1.7e-63 213.0 COG0322@1|root,COG0322@2|Bacteria,3J0F1@40117|Nitrospirae 40117|Nitrospirae L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N k59_1079381_1 1123368.AUIS01000007_gene2811 2.42e-78 251.0 COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,1RWK9@1236|Gammaproteobacteria,2NBVK@225057|Acidithiobacillales 225057|Acidithiobacillales L DNA polymerase - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP k59_398970_1 765914.ThisiDRAFT_2286 1.17e-11 63.5 COG3431@1|root,COG3431@2|Bacteria,1N6PE@1224|Proteobacteria,1SE25@1236|Gammaproteobacteria,1WZBZ@135613|Chromatiales 135613|Chromatiales S BLUF domain protein - - - - - - - - - - - - BLUF k59_1598341_1 33898.JRHJ01000055_gene5862 4.34e-35 135.0 COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria 201174|Actinobacteria E amidohydrolase - - - - - - - - - - - - Amidohydro_3 k59_15773_1 1439940.BAY1663_01074 1.57e-96 301.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria 1236|Gammaproteobacteria J L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) aspS GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iSFV_1184.SFV_1868 GAD,tRNA-synt_2,tRNA_anti-codon k59_15773_2 1348657.M622_11760 2.42e-37 134.0 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2VH65@28216|Betaproteobacteria,2KV5C@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_1509407_1 267608.RSc0713 1.58e-107 323.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2VH6S@28216|Betaproteobacteria,1K0U6@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_871341_3 1054213.HMPREF9946_04460 0.000444 43.5 COG4333@1|root,COG4333@2|Bacteria,1N19M@1224|Proteobacteria,2U5K3@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - DUF1643 k59_1509410_1 985665.HPL003_22090 3.78e-22 99.4 COG0715@1|root,COG0715@2|Bacteria,1TPAD@1239|Firmicutes,4HG8X@91061|Bacilli,26W8E@186822|Paenibacillaceae 91061|Bacilli P NMT1/THI5 like - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1 k59_871342_1 1396141.BATP01000040_gene2127 8.67e-35 138.0 COG0515@1|root,COG0515@2|Bacteria,46UX7@74201|Verrucomicrobia,2IVEF@203494|Verrucomicrobiae 203494|Verrucomicrobiae KLT Protein tyrosine kinase - - - - - - - - - - - - Pkinase k59_402160_1 996637.SGM_2867 7.31e-27 111.0 COG0524@1|root,COG0524@2|Bacteria,2I04R@201174|Actinobacteria 201174|Actinobacteria G Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway rbsK - 2.7.1.15 ko:K00852 ko00030,map00030 - R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_144122_1 398525.KB900701_gene4968 9.94e-73 241.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,3JQNW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.54 ko:K17686,ko:K19597 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5,3.A.3.5.20 - - E1-E2_ATPase,HMA,Hydrolase k59_1509413_1 238854.Q5GQW5_BPSYP 4.89e-76 265.0 4QI3D@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_515981_1 1123274.KB899411_gene3129 1.79e-74 249.0 COG0058@1|root,COG0058@2|Bacteria,2J5KC@203691|Spirochaetes 203691|Spirochaetes G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_187112_1 1336237.JAEE01000002_gene1303 1.17e-67 230.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria 1236|Gammaproteobacteria L ATP-dependent helicase hrpA hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_557695_2 338963.Pcar_3089 1.03e-15 74.7 COG0177@1|root,COG0177@2|Bacteria,1N2HB@1224|Proteobacteria,430KB@68525|delta/epsilon subdivisions,2WW2A@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate - - - - - - - - - - - - - k59_457263_2 998088.B565_0285 3.69e-32 124.0 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1Y3XQ@135624|Aeromonadales 135624|Aeromonadales L Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_144134_1 856793.MICA_2379 1.25e-81 261.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,4BPQE@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Acetyl-CoA dehydrogenase C-terminal like mmgC - 1.3.8.1,1.3.8.7 ko:K00248,ko:K00249 ko00071,ko00280,ko00410,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map01100,map01110,map01120,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_1336726_1 330214.NIDE0234 1.72e-28 107.0 COG0852@1|root,COG0852@2|Bacteria,3J168@40117|Nitrospirae 40117|Nitrospirae C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_1336726_2 330214.NIDE0235 9.68e-94 275.0 COG0377@1|root,COG0377@2|Bacteria,3J11S@40117|Nitrospirae 40117|Nitrospirae C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_557707_2 870187.Thini_4373 1.15e-62 204.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,45ZYU@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1392162_1 502025.Hoch_5959 4.01e-84 254.0 COG5421@1|root,COG5421@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2 k59_1083279_1 879310.HMPREF9162_1775 5.34e-37 135.0 COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,4H954@909932|Negativicutes 909932|Negativicutes I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - - IspD k59_187134_1 690850.Desaf_3114 2.98e-42 141.0 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,42TPU@68525|delta/epsilon subdivisions,2WQ1M@28221|Deltaproteobacteria,2MC2A@213115|Desulfovibrionales 28221|Deltaproteobacteria O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_187134_2 105425.BBPL01000008_gene1524 8.56e-13 67.8 COG0560@1|root,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,2NHIB@228398|Streptacidiphilus 201174|Actinobacteria E haloacid dehalogenase-like hydrolase serB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - HAD k59_402201_1 1489678.RDMS_12970 1.58e-71 239.0 COG0466@1|root,COG0466@2|Bacteria,1WISX@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon2 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_245932_1 640081.Dsui_1451 6.35e-55 180.0 COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,2VJ1K@28216|Betaproteobacteria,2KUV6@206389|Rhodocyclales 206389|Rhodocyclales T (FHA) domain - - - - - - - - - - - - FHA k59_717960_1 330214.NIDE0426 8.01e-232 649.0 COG0539@1|root,COG1185@1|root,COG0539@2|Bacteria,COG1185@2|Bacteria,3J0CA@40117|Nitrospirae 40117|Nitrospirae J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_458254_1 1236514.BAKL01000052_gene3736 6.99e-07 49.3 COG3023@1|root,COG3023@2|Bacteria,4P37K@976|Bacteroidetes,2FRZB@200643|Bacteroidia,4AQTH@815|Bacteroidaceae 976|Bacteroidetes V N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01447 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Amidase_2 k59_403357_1 153721.MYP_3211 1.04e-36 141.0 COG0531@1|root,COG0531@2|Bacteria,4P19H@976|Bacteroidetes 976|Bacteroidetes E Amino acid permease - - - - - - - - - - - - AA_permease_2 k59_1451614_1 1448389.BAVQ01000043_gene1922 2.17e-22 97.8 COG1403@1|root,COG1403@2|Bacteria,2HAHI@201174|Actinobacteria 201174|Actinobacteria V HNH endonuclease - - - - - - - - - - - - DUF222,HNH k59_188255_1 709991.Odosp_1945 8.3e-06 47.8 2ARAZ@1|root,31GKZ@2|Bacteria,4NKJD@976|Bacteroidetes,2FPQT@200643|Bacteroidia,22Y6A@171551|Porphyromonadaceae 976|Bacteroidetes S Domain of unknown function (DUF3332) - - - - - - - - - - - - DUF3332 k59_188255_2 575540.Isop_3098 1.05e-100 315.0 COG1520@1|root,COG1520@2|Bacteria,2IWVH@203682|Planctomycetes 203682|Planctomycetes S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - k59_245947_2 589865.DaAHT2_2418 1.55e-28 105.0 2EK3B@1|root,33DTR@2|Bacteria,1NZVR@1224|Proteobacteria,431VY@68525|delta/epsilon subdivisions,2WWMN@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_145137_1 1120933.ATUY01000002_gene83 2.64e-09 63.2 COG0553@1|root,COG0553@2|Bacteria,2IC31@201174|Actinobacteria,4D420@85005|Actinomycetales 201174|Actinobacteria KL SNF2 family N-terminal domain protein - - - - - - - - - - - - SNF2_N k59_245954_1 1502770.JQMG01000001_gene967 1.53e-56 198.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,2KKTM@206350|Nitrosomonadales 206350|Nitrosomonadales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_872494_1 1089545.KB913037_gene2298 5.3e-47 171.0 COG3696@1|root,COG3696@2|Bacteria,2I53X@201174|Actinobacteria,4EE9U@85010|Pseudonocardiales 201174|Actinobacteria P AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_1511061_1 1144275.COCOR_03850 1.3e-09 57.0 2EE6A@1|root,3380W@2|Bacteria,1NCBW@1224|Proteobacteria,42V9R@68525|delta/epsilon subdivisions,2WSI3@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1511061_2 224324.aq_1741 6.12e-12 66.6 COG2510@1|root,COG2510@2|Bacteria 2|Bacteria EG membrane - - - ko:K08978 - - - - ko00000,ko02000 2.A.7.2 - - EamA k59_872497_1 1458275.AZ34_10720 9.88e-49 172.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,4A9JN@80864|Comamonadaceae 28216|Betaproteobacteria U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_610365_1 1132442.KB889752_gene335 2.58e-23 107.0 COG2370@1|root,COG2370@2|Bacteria,1V704@1239|Firmicutes,4HINW@91061|Bacilli,1ZBRA@1386|Bacillus 91061|Bacilli O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_1084452_1 313596.RB2501_04835 1.71e-07 52.4 COG0213@1|root,COG0213@2|Bacteria,4NFVB@976|Bacteroidetes,1HZ41@117743|Flavobacteriia 976|Bacteroidetes F Pyrimidine nucleoside phosphorylase C-terminal domain - - 2.4.2.2,2.4.2.4 ko:K00756,ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R01876,R02296,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C k59_1084452_2 1444711.CCJF01000003_gene87 1.19e-60 195.0 COG0462@1|root,COG0462@2|Bacteria 2|Bacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran,Pribosyltran_N k59_145142_1 1041930.Mtc_1668 7.5e-64 211.0 COG1131@1|root,arCOG00196@2157|Archaea,2Y7M5@28890|Euryarchaeota,2NBN9@224756|Methanomicrobia 28890|Euryarchaeota V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990,ko:K09695 ko02010,map02010 M00252,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.102 - - ABC_tran,DUF4162 k59_17699_2 706587.Desti_2873 1.19e-51 178.0 COG2006@1|root,COG2006@2|Bacteria 2|Bacteria U 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - - - - - - - - - - DUF362 k59_245965_1 1493507.A0A0E3FFA2_9CAUD 6.79e-76 230.0 4QK59@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_676550_1 1380394.JADL01000014_gene153 1.17e-135 414.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria,2JP8A@204441|Rhodospirillales 204441|Rhodospirillales C FAD linked oxidases, C-terminal domain - - - ko:K18930 - - - - ko00000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_99581_1 987059.RBXJA2T_19256 7.32e-109 335.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,1KJEG@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_1244392_1 404589.Anae109_2754 1.57e-93 285.0 COG1148@1|root,COG1148@2|Bacteria,1PTJ7@1224|Proteobacteria,42NJN@68525|delta/epsilon subdivisions,2WJHG@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_6 k59_833701_1 1208321.D104_18060 1.28e-114 343.0 COG1953@1|root,COG1953@2|Bacteria,1MV18@1224|Proteobacteria,1RSR2@1236|Gammaproteobacteria,1XIA6@135619|Oceanospirillales 135619|Oceanospirillales FH cytosine purines uracil thiamine allantoin - - - ko:K03457 - - - - ko00000 2.A.39 - - Transp_cyt_pur k59_718006_1 745310.G432_10700 6.97e-108 335.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TQMV@28211|Alphaproteobacteria,2K32Q@204457|Sphingomonadales 204457|Sphingomonadales G PQQ-like domain - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 k59_976532_1 1156937.MFUM_700069 8.95e-38 143.0 COG0843@1|root,COG0843@2|Bacteria,46S4Q@74201|Verrucomicrobia,37GA2@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia C Cytochrome C and Quinol oxidase polypeptide I - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_976532_2 1434325.AZQN01000003_gene2258 3.41e-07 52.4 COG1622@1|root,COG1622@2|Bacteria,4NFNF@976|Bacteroidetes,47JF8@768503|Cytophagia 976|Bacteroidetes C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) ctaC - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM k59_676570_1 1502851.FG93_02996 0.000973 41.6 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TQJC@28211|Alphaproteobacteria,3JU9K@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EP Binding-protein-dependent transport system inner membrane component MA20_01205 - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_676570_2 398511.BpOF4_05730 2.56e-35 138.0 COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,4HARF@91061|Bacilli,1ZC4E@1386|Bacillus 91061|Bacilli E COG0747 ABC-type dipeptide transport system, periplasmic component appA - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_718008_1 1144307.PMI04_00622 4.68e-73 235.0 COG2030@1|root,COG2030@2|Bacteria,1NTV7@1224|Proteobacteria,2UQFU@28211|Alphaproteobacteria,2K8I3@204457|Sphingomonadales 204457|Sphingomonadales I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydrat_N k59_718008_2 1462527.CCDM010000003_gene4125 3.41e-09 58.9 COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HA2G@91061|Bacilli,23K05@182709|Oceanobacillus 91061|Bacilli IQ AMP-binding enzyme C-terminal domain lcfA - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1136506_1 713586.KB900536_gene1560 2.33e-98 308.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales 135613|Chromatiales G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_676576_1 765914.ThisiDRAFT_0926 4.98e-33 120.0 COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1WX5A@135613|Chromatiales 135613|Chromatiales U PFAM MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_676576_2 472759.Nhal_0528 2.76e-25 99.0 COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,1S90K@1236|Gammaproteobacteria,1WYEK@135613|Chromatiales 135613|Chromatiales U PFAM Biopolymer transport protein ExbD TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_610394_1 1048339.KB913029_gene1211 3.32e-86 260.0 COG4122@1|root,COG4122@2|Bacteria,2GP7A@201174|Actinobacteria,4ETYD@85013|Frankiales 201174|Actinobacteria S O-methyltransferase mdmC - 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_3 k59_1393131_1 436308.Nmar_0513 6.86e-54 170.0 arCOG10528@1|root,arCOG10528@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1393131_2 436308.Nmar_0512 5.78e-62 198.0 COG1522@1|root,arCOG01628@2157|Archaea,41SA2@651137|Thaumarchaeota 651137|Thaumarchaeota K COG1522 Transcriptional regulators - - - - - - - - - - - - - k59_1664422_1 1123376.AUIU01000014_gene569 6.29e-05 45.8 COG0442@1|root,COG0442@2|Bacteria,3J0EY@40117|Nitrospirae 40117|Nitrospirae J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_1664422_2 283699.D172_1543 9.77e-59 192.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,2PZN4@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750 OMPdecase k59_833721_1 1283300.ATXB01000001_gene982 9.27e-11 60.5 COG1853@1|root,COG1853@2|Bacteria,1QSGJ@1224|Proteobacteria,1S5ST@1236|Gammaproteobacteria,1XF9G@135618|Methylococcales 135618|Methylococcales S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct k59_517676_1 1232410.KI421425_gene1552 8.08e-71 242.0 COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales 28221|Deltaproteobacteria M OmpA family - - - - - - - - - - - - OmpA k59_145172_1 518766.Rmar_2008 1.38e-54 183.0 COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,1FJ1P@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79 ko:K00128,ko:K00135 ko00010,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130 M00027,M00135 R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_517677_1 1217718.ALOU01000040_gene135 3.57e-67 218.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VJNE@28216|Betaproteobacteria 28216|Betaproteobacteria C 3-isopropylmalate dehydratase large subunit - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_99608_1 391598.FBBAL38_05895 4.62e-53 183.0 COG0388@1|root,COG0388@2|Bacteria,4NEAQ@976|Bacteroidetes,1HWST@117743|Flavobacteriia 976|Bacteroidetes S Carbon-nitrogen hydrolase ramA_2 - - - - - - - - - - - Acetyltransf_1,CN_hydrolase k59_1303584_1 268746.Q58MP3_BPPRM 2.39e-116 399.0 4QBUC@10239|Viruses,4QQGQ@28883|Caudovirales,4QHY3@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1511122_1 1255043.TVNIR_3740 1.27e-98 312.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1WWSC@135613|Chromatiales 135613|Chromatiales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_99621_1 1122604.JONR01000033_gene45 2.71e-74 249.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,1S0DF@1236|Gammaproteobacteria 1236|Gammaproteobacteria K AAA ATPase domain - - - - - - - - - - - - AAA_16,BTAD,Guanylate_cyc k59_517693_1 561229.Dd1591_0570 1.21e-24 108.0 COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,1RMQ1@1236|Gammaproteobacteria,2JD58@204037|Dickeya 1236|Gammaproteobacteria L DNA-directed DNA polymerase polB GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02336 - - - - ko00000,ko01000,ko03400 - - - DNA_pol_B,DNA_pol_B_exo1 k59_1543239_1 153948.NAL212_1200 1.77e-56 197.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2VP0G@28216|Betaproteobacteria 28216|Betaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_458330_1 1157943.KB892705_gene574 1.72e-49 171.0 COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria,234M1@1762|Mycobacteriaceae 201174|Actinobacteria C ferredoxin oxidoreductase korB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016625,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0047553,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_610419_1 323098.Nwi_0692 3.67e-21 95.1 COG1235@1|root,COG1235@2|Bacteria,1MWI5@1224|Proteobacteria,2TQX4@28211|Alphaproteobacteria,3JRTT@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S May be involved in the transport of PQQ or its precursor to the periplasm pqqB - - ko:K06136 - - - - ko00000 - - - Lactamase_B_2 k59_833754_1 444860.E3SJ04_9CAUD 2.77e-188 535.0 4QHDM@10239|Viruses,4QYV6@35237|dsDNA viruses no RNA stage,4QRD0@28883|Caudovirales,4QI2W@10662|Myoviridae 10662|Myoviridae S Terminase-like family - GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016032,GO:0016043,GO:0016787,GO:0016788,GO:0019058,GO:0019068,GO:0019069,GO:0019072,GO:0019075,GO:0022607,GO:0032991,GO:0034641,GO:0043170,GO:0043493,GO:0044085,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0046483,GO:0046797,GO:0051704,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0098009,GO:1901360,GO:1902494,GO:1904949 - - - - - - - - - - - k59_1244440_1 525368.HMPREF0591_3287 3.98e-20 94.4 COG1020@1|root,COG1020@2|Bacteria,2I5H8@201174|Actinobacteria,232A1@1762|Mycobacteriaceae 201174|Actinobacteria I Belongs to the long-chain O-acyltransferase family - GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - DUF1298,WES_acyltransf k59_1029000_1 1336803.PHEL49_0907 7.36e-09 59.7 2ATWF@1|root,31JFP@2|Bacteria,4NQ9K@976|Bacteroidetes,1I3SN@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_876916_1 1229909.NSED_00940 2.28e-72 224.0 COG0788@1|root,arCOG02826@2157|Archaea,41S78@651137|Thaumarchaeota 651137|Thaumarchaeota F Formyl transferase - - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT_6,Formyl_trans_N k59_876916_2 1229909.NSED_00935 9.45e-16 74.3 COG1402@1|root,arCOG04536@2157|Archaea,41SNC@651137|Thaumarchaeota 651137|Thaumarchaeota H Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase k59_1455606_1 28532.XP_010535146.1 1.24e-10 67.0 COG1398@1|root,KOG1600@2759|Eukaryota,37K2J@33090|Viridiplantae,3GDZY@35493|Streptophyta,3HP9F@3699|Brassicales 35493|Streptophyta I fatty acid desaturase - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006636,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009314,GO:0009416,GO:0009579,GO:0009628,GO:0009642,GO:0009644,GO:0009892,GO:0009987,GO:0010109,GO:0010205,GO:0012505,GO:0016020,GO:0016053,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031984,GO:0032787,GO:0033559,GO:0042175,GO:0042548,GO:0043155,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043467,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0071704,GO:0072330,GO:0098827,GO:1901576,GO:1905156 1.14.19.1,1.14.19.42 ko:K00507,ko:K20416 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_1341568_1 2423.NA23_0205425 1.29e-92 291.0 COG5012@1|root,COG5012@2|Bacteria,2GCP6@200918|Thermotogae 200918|Thermotogae S D-Lysine 5,6-aminomutase alpha subunit - - 5.4.3.5 ko:K17898 ko00472,map00472 - R02461 RC00719 ko00000,ko00001,ko01000 - - - B12-binding,Lys-AminoMut_A,OAM_dimer k59_563226_1 1279017.AQYJ01000026_gene325 8.08e-28 103.0 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,1S8RT@1236|Gammaproteobacteria,467U2@72275|Alteromonadaceae 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_563226_2 1122211.JMLW01000003_gene1825 4.14e-48 160.0 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,1XJBJ@135619|Oceanospirillales 135619|Oceanospirillales J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_876927_1 869210.Marky_1221 2.3e-58 201.0 COG0173@1|root,COG0173@2|Bacteria,1WIEA@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_1341579_1 1449976.KALB_7013 8.82e-63 206.0 COG1946@1|root,COG1946@2|Bacteria,2GJ1B@201174|Actinobacteria,4DX4D@85010|Pseudonocardiales 201174|Actinobacteria I Acyl-CoA thioesterase tesB - - ko:K10805 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT_3 k59_771709_1 631362.Thi970DRAFT_04215 1.7e-77 236.0 COG3751@1|root,COG3751@2|Bacteria,1RBXB@1224|Proteobacteria,1RR8W@1236|Gammaproteobacteria,1WWUG@135613|Chromatiales 135613|Chromatiales O 2OG-Fe(II) oxygenase superfamily - - - - - - - - - - - - 2OG-FeII_Oxy_3 k59_408254_1 502025.Hoch_4096 3.33e-57 197.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,42QDJ@68525|delta/epsilon subdivisions,2WIJ9@28221|Deltaproteobacteria,2Z2XS@29|Myxococcales 28221|Deltaproteobacteria G Maltogenic Amylase, C-terminal domain treS - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - APH,Alpha-amylase,Malt_amylase_C k59_408254_2 62928.azo1726 2.12e-28 114.0 COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,2VK9R@28216|Betaproteobacteria,2KYHA@206389|Rhodocyclales 206389|Rhodocyclales F Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB - - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - DUF3416 k59_193089_1 313612.L8106_23555 2.66e-06 48.9 COG2095@1|root,COG2095@2|Bacteria 2|Bacteria U MarC family integral membrane protein IV02_12955 - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_193089_2 1120983.KB894575_gene467 1.33e-20 90.9 COG2113@1|root,COG2113@2|Bacteria,1QU64@1224|Proteobacteria,2TZ6V@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Substrate binding domain of ABC-type glycine betaine transport system - - - ko:K02002 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - OpuAC k59_1186867_2 436308.Nmar_1506 1.47e-57 178.0 arCOG08672@1|root,arCOG08672@2157|Archaea,41SU2@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_723776_1 444860.E3SJA1_9CAUD 1.25e-29 119.0 4QCVH@10239|Viruses,4QVG6@35237|dsDNA viruses no RNA stage 10239|Viruses S transferase activity - - - - - - - - - - - - - k59_1606462_1 444862.E3SLP7_9CAUD 8.38e-14 67.4 4QFA3@10239|Viruses,4QQEQ@28883|Caudovirales,4QI4M@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1343101_2 349124.Hhal_2375 8.42e-09 58.2 COG4795@1|root,COG4795@2|Bacteria 2|Bacteria U General secretion pathway protein gspJ - - ko:K02459 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSJ k59_616878_1 28444.JODQ01000005_gene1571 3.51e-47 166.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4EFZR@85012|Streptosporangiales 201174|Actinobacteria Q Cytochrome P450 cyp20 - 1.14.14.1 ko:K00493 ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120 - R03629,R04121,R05259 RC00046,RC01311 ko00000,ko00001,ko01000 - - - p450 k59_251678_1 459495.SPLC1_S032560 5.99e-17 90.1 COG1749@1|root,COG2931@1|root,COG1749@2|Bacteria,COG2931@2|Bacteria,1G0DX@1117|Cyanobacteria,1HH6X@1150|Oscillatoriales 1117|Cyanobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - Cadherin_3,DUF11,DUF4347,HemolysinCabind,Laminin_G_3,VCBS k59_1249816_1 1165096.ARWF01000001_gene996 3.46e-22 92.8 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2VIRP@28216|Betaproteobacteria,2KKI7@206350|Nitrosomonadales 206350|Nitrosomonadales G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) - - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_1249816_2 377629.TERTU_3260 7.47e-20 84.7 COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,1SD3P@1236|Gammaproteobacteria,2PNVR@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria U Preprotein translocase SecG subunit secG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_564587_1 1173027.Mic7113_0671 1.68e-62 202.0 COG4360@1|root,COG4360@2|Bacteria,1G2S9@1117|Cyanobacteria,1H6XH@1150|Oscillatoriales 1117|Cyanobacteria F ATP adenylyltransferase apa2 - 2.7.7.53 ko:K00988 ko00230,map00230 - R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 - - - ATP_transf k59_1034596_2 96561.Dole_0563 2.18e-43 149.0 2A4CF@1|root,30SY3@2|Bacteria,1RFXP@1224|Proteobacteria,42RIM@68525|delta/epsilon subdivisions,2WNS6@28221|Deltaproteobacteria,2MNMZ@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - Yip1 k59_723793_1 335283.Neut_2188 3.97e-38 145.0 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,2VNM0@28216|Betaproteobacteria,37405@32003|Nitrosomonadales 28216|Betaproteobacteria H PFAM Orn DAP Arg decarboxylase 2 speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_616900_3 1159870.KB907784_gene2484 0.000156 45.1 COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,2VI5F@28216|Betaproteobacteria,3T6XM@506|Alcaligenaceae 28216|Betaproteobacteria M COG2230 Cyclopropane fatty acid synthase and related methyltransferases - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_723801_1 859657.RPSI07_3114 2.24e-19 91.3 COG2267@1|root,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria,2WHBS@28216|Betaproteobacteria,1KIKH@119060|Burkholderiaceae 28216|Betaproteobacteria I Alpha/beta hydrolase family - - 3.1.1.24 ko:K01055 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00568 R02991 RC00825 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1 k59_616909_1 395965.Msil_1290 7.1e-61 198.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,3NBII@45404|Beijerinckiaceae 28211|Alphaproteobacteria L HTH-like domain - - - - - - - - - - - - HTH_21,rve,rve_3 k59_1457187_1 1333998.M2A_0904 1.1e-93 278.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,4BQ1Z@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O Belongs to the GST superfamily - - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_N,GST_N_2,GST_N_3 k59_358957_1 439375.Oant_1410 7.08e-160 466.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,1J2R0@118882|Brucellaceae 28211|Alphaproteobacteria EH Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1090661_1 195250.CM001776_gene1360 6.74e-78 238.0 COG0512@1|root,COG0512@2|Bacteria,1G0QK@1117|Cyanobacteria,1GZ8F@1129|Synechococcus 1117|Cyanobacteria EH Anthranilate synthase trpG - 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_934141_1 1380394.JADL01000004_gene5741 5.11e-92 276.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2TSVS@28211|Alphaproteobacteria,2JQE0@204441|Rhodospirillales 204441|Rhodospirillales S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_464496_1 1174528.JH992893_gene5975 5.06e-86 283.0 COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1G15G@1117|Cyanobacteria,1JHXK@1189|Stigonemataceae 1117|Cyanobacteria G Transaldolase/Fructose-6-phosphate aldolase - - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k59_564619_1 983545.Glaag_0851 1.19e-46 162.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,46506@72275|Alteromonadaceae 1236|Gammaproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECS88_1305.ECS88_0100 LpxC k59_878227_1 1229909.NSED_01545 8.57e-85 255.0 COG0063@1|root,arCOG00018@2157|Archaea,41SHM@651137|Thaumarchaeota 651137|Thaumarchaeota G Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX nnrE - 5.1.99.6 ko:K17759 - - - - ko00000,ko01000 - - - YjeF_N k59_20274_1 28564.XP_002341414.1 9.63e-31 127.0 2EB3Y@1|root,2SH94@2759|Eukaryota,39VZP@33154|Opisthokonta,3NZDK@4751|Fungi,3QK4D@4890|Ascomycota,20BI2@147545|Eurotiomycetes,3SBX5@5042|Eurotiales 4751|Fungi G Belongs to the tannase family - - - - - - - - - - - - Tannase k59_1549620_2 1163617.SCD_n02434 2.83e-40 150.0 COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria 28216|Betaproteobacteria G 4-alpha-glucanotransferase treY - 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Alpha-amylase,Glyco_hydro_77 k59_1186953_1 1229780.BN381_10319 1.94e-49 169.0 COG2050@1|root,COG2050@2|Bacteria,2I11Y@201174|Actinobacteria,3UXR4@52018|unclassified Actinobacteria (class) 201174|Actinobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_1186953_3 4006.Lus10033594 0.000163 44.3 COG0265@1|root,KOG1421@2759|Eukaryota,37M01@33090|Viridiplantae,3G8IE@35493|Streptophyta,4JN34@91835|fabids 35493|Streptophyta O protease Do-like - - - - - - - - - - - - PDZ_1,PDZ_2,Trypsin_2 k59_464515_2 1397527.Q670_03235 6.24e-76 252.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,1XKXZ@135619|Oceanospirillales 135619|Oceanospirillales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_464515_3 566466.NOR53_2438 1.08e-160 466.0 COG3659@1|root,COG3659@2|Bacteria,1R8TI@1224|Proteobacteria,1S21B@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Carbohydrate-selective porin OprB - - - ko:K07267 - - - - ko00000,ko02000 1.B.19.1 - - OprB k59_464515_5 56780.SYN_00391 1.95e-96 290.0 COG1879@1|root,COG1879@2|Bacteria,1R8FV@1224|Proteobacteria 1224|Proteobacteria G Periplasmic binding protein domain - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_980632_1 1229909.NSED_08915 3.57e-71 230.0 arCOG08793@1|root,arCOG08812@1|root,arCOG08793@2157|Archaea,arCOG08812@2157|Archaea,41T0K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_616971_1 1121090.KB894694_gene2110 1.2e-14 75.1 COG3181@1|root,COG3181@2|Bacteria,1V0HH@1239|Firmicutes,4HF4M@91061|Bacilli,1ZR9H@1386|Bacillus 91061|Bacilli S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_616971_2 1121020.JIAG01000001_gene1113 1.16e-14 73.2 COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,1W8ET@1268|Micrococcaceae 201174|Actinobacteria I Belongs to the thiolase family paaJ - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_980643_1 643867.Ftrac_0196 1.05e-62 207.0 COG3104@1|root,COG3104@2|Bacteria,4NE8R@976|Bacteroidetes,47JX4@768503|Cytophagia 976|Bacteroidetes E TIGRFAM amino acid peptide transporter (Peptide H symporter), bacterial - - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 k59_150783_1 1123376.AUIU01000011_gene1071 8.54e-27 108.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,3J0AI@40117|Nitrospirae 40117|Nitrospirae J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_150783_2 397287.C807_03632 2.72e-29 120.0 COG2812@1|root,COG2812@2|Bacteria,1VCQC@1239|Firmicutes,248U4@186801|Clostridia,27IHW@186928|unclassified Lachnospiraceae 186801|Clostridia L DNA polymerase III, delta subunit holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C k59_464533_1 977880.RALTA_A0171 1.23e-58 191.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria,1JZSS@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_307065_1 264462.Bd3760 1.62e-53 185.0 COG0342@1|root,COG0342@2|Bacteria,1MVFS@1224|Proteobacteria,43CA4@68525|delta/epsilon subdivisions,2MUTB@213481|Bdellovibrionales,2WVA3@28221|Deltaproteobacteria 213481|Bdellovibrionales U Glutamate-cysteine ligase - - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - GshA k59_1457275_1 583355.Caka_1985 5.65e-39 141.0 COG2327@1|root,COG2327@2|Bacteria 2|Bacteria S slime layer polysaccharide biosynthetic process wgaD - - - - - - - - - - - PS_pyruv_trans k59_194911_1 37919.EP51_05655 1.06e-44 158.0 COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria,4FVZY@85025|Nocardiaceae 201174|Actinobacteria E Alcohol dehydrogenase GroES-like domain adh - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_150794_1 1381123.AYOD01000030_gene485 1.58e-32 126.0 COG3219@1|root,COG3219@2|Bacteria,1QAP4@1224|Proteobacteria,2TTIN@28211|Alphaproteobacteria,43K79@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Putative DNA-binding domain - - - - - - - - - - - - DUF2063 k59_150794_2 1279038.KB907339_gene1255 1.7e-11 62.4 COG2259@1|root,COG2259@2|Bacteria,1N1VA@1224|Proteobacteria,2TVZ9@28211|Alphaproteobacteria,2JU1T@204441|Rhodospirillales 204441|Rhodospirillales S DoxX - - - - - - - - - - - - DoxX k59_934215_1 450851.PHZ_p0133 5.44e-20 88.6 COG0167@1|root,COG0167@2|Bacteria,1MXER@1224|Proteobacteria 1224|Proteobacteria C Dihydroorotate dehydrogenase - - 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_934215_2 1122994.AUFR01000031_gene590 3.9e-39 146.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1149@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1149@2|Bacteria,2I995@201174|Actinobacteria,4DVUV@85009|Propionibacteriales 201174|Actinobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K00169,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_359034_2 397945.Aave_3942 2.03e-70 225.0 COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2VM8X@28216|Betaproteobacteria,4AB7P@80864|Comamonadaceae 28216|Betaproteobacteria S Putative cyclase - - - - - - - - - - - - Cyclase k59_410056_1 983917.RGE_41780 4.92e-22 96.7 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VHZU@28216|Betaproteobacteria,1KJ38@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_1398691_1 1417296.U879_08050 6.7e-80 248.0 COG1856@1|root,COG1856@2|Bacteria,1R6PW@1224|Proteobacteria,2U1YU@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Radical SAM - - - ko:K09711 - - - - ko00000 - - - Radical_SAM k59_934221_1 1116472.MGMO_83c00160 1.56e-33 127.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1XESH@135618|Methylococcales 135618|Methylococcales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_934221_2 555778.Hneap_0610 1.87e-41 150.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1WVVJ@135613|Chromatiales 135613|Chromatiales F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_307080_1 401526.TcarDRAFT_0308 7.05e-57 183.0 COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,4H3YT@909932|Negativicutes 909932|Negativicutes J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_307080_2 123214.PERMA_0074 1.33e-11 60.8 COG0291@1|root,COG0291@2|Bacteria,2G4E2@200783|Aquificae 200783|Aquificae J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_307080_3 1111069.TCCBUS3UF1_9210 1.83e-36 127.0 COG0292@1|root,COG0292@2|Bacteria,1WK7V@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_1606552_1 1304880.JAGB01000001_gene487 9.96e-204 569.0 COG4030@1|root,COG4030@2|Bacteria,1TRZY@1239|Firmicutes,249GP@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF2961 k59_150820_1 1173022.Cri9333_1446 6.72e-32 129.0 COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1GQ5I@1117|Cyanobacteria,1H7Y2@1150|Oscillatoriales 1117|Cyanobacteria T COGs COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - EAL,GAF,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_1187027_1 1408418.JNJH01000078_gene317 1.8e-20 89.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria,2JQG3@204441|Rhodospirillales 204441|Rhodospirillales E Cysteine synthase cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_723902_2 1395571.TMS3_0118235 5.06e-25 105.0 COG0683@1|root,COG2010@1|root,COG0683@2|Bacteria,COG2010@2|Bacteria,1R9N0@1224|Proteobacteria,1S351@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Periplasmic binding protein - - - - - - - - - - - - Cytochrom_C,Peripla_BP_6 k59_1187037_1 330214.NIDE3041 2.37e-34 122.0 COG0764@1|root,COG0764@2|Bacteria,3J0NG@40117|Nitrospirae 40117|Nitrospirae I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_1187037_2 111781.Lepto7376_1242 7.83e-14 72.8 COG1043@1|root,COG1043@2|Bacteria,1G1V3@1117|Cyanobacteria,1H812@1150|Oscillatoriales 1117|Cyanobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - iJN678.lpxA Acetyltransf_11,Hexapep k59_410098_1 1144275.COCOR_07460 2.27e-96 300.0 COG0277@1|root,COG0277@2|Bacteria,1QZTK@1224|Proteobacteria,43CNH@68525|delta/epsilon subdivisions,2X7VU@28221|Deltaproteobacteria 28221|Deltaproteobacteria C D-arabinono-1,4-lactone oxidase - - - - - - - - - - - - ALO,FAD_binding_4 k59_937853_3 1298608.JCM18900_13032 7.36e-18 78.2 2E5JD@1|root,330AQ@2|Bacteria,1N86Q@1224|Proteobacteria,1SC9N@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1553382_1 1266845.Q783_04870 1.18e-24 105.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HA3S@91061|Bacilli,27FMU@186828|Carnobacteriaceae 91061|Bacilli V ABC transporter transmembrane region mdlB - - ko:K06147,ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1553382_2 161934.XP_010688438.1 4.1e-50 177.0 COG0153@1|root,KOG0631@2759|Eukaryota,37KN0@33090|Viridiplantae,3GHHX@35493|Streptophyta 35493|Streptophyta G galacturonokinase activity - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019586,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046396,GO:0046835,GO:0047912,GO:0071704 2.7.1.44 ko:K18677,ko:K19347 ko00520,map00520 - R01980 RC00002,RC00078 ko00000,ko00001,ko01000,ko03036 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg k59_254804_1 1049564.TevJSym_ad01330 2.33e-129 379.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1J4V5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_569201_1 1085623.GNIT_0106 4.59e-41 155.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,1RPFW@1236|Gammaproteobacteria,465DX@72275|Alteromonadaceae 1236|Gammaproteobacteria I Carboxylesterase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_1404409_2 330214.NIDE1258 2.27e-35 124.0 COG1522@1|root,COG1522@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_1404418_1 596151.DesfrDRAFT_0307 1.32e-29 114.0 COG4976@1|root,COG4976@2|Bacteria,1RJBE@1224|Proteobacteria,43EBW@68525|delta/epsilon subdivisions,2X09D@28221|Deltaproteobacteria,2MBBY@213115|Desulfovibrionales 28221|Deltaproteobacteria S Methionine biosynthesis protein MetW - - - - - - - - - - - - Methyltransf_25 k59_1192893_1 861299.J421_2170 1.21e-47 171.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_986507_1 1131814.JAFO01000001_gene3553 8.52e-34 134.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRII@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases - - 6.2.1.32 ko:K08295 ko00627,ko01120,map00627,map01120 - R00982 RC00004,RC00174 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_312577_6 1089111.G8I7V8_9CAUD 1.13e-07 53.1 4QGDB@10239|Viruses,4QZHU@35237|dsDNA viruses no RNA stage,4QSG0@28883|Caudovirales,4QM88@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_469914_1 518766.Rmar_2012 3.25e-104 323.0 COG4263@1|root,COG4263@2|Bacteria,4NFNE@976|Bacteroidetes,1FIVE@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Nitrous oxide reductase nosZ - 1.7.2.4 ko:K00376 ko00910,ko01120,map00910,map01120 M00529 R02804 RC02861 ko00000,ko00001,ko00002,ko01000 - - - - k59_256224_1 204536.SULAZ_0684 6.64e-64 211.0 COG0215@1|root,COG0215@2|Bacteria,2G3JG@200783|Aquificae 200783|Aquificae J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_364301_1 330214.NIDE0423 1.04e-74 237.0 COG0128@1|root,COG0128@2|Bacteria,3J0BZ@40117|Nitrospirae 40117|Nitrospirae E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_1192917_2 113395.AXAI01000013_gene6862 1.6e-10 61.6 COG2114@1|root,COG3899@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,COG3903@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_1404442_1 665942.HMPREF1022_00488 6.53e-85 275.0 COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria,2M9FS@213115|Desulfovibrionales 28221|Deltaproteobacteria C Glycine radical - - 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like k59_1555298_1 159087.Daro_2048 3.44e-54 191.0 COG3290@1|root,COG5001@1|root,COG3290@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KVRJ@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS,Response_reg k59_1349133_1 1333998.M2A_2211 7.62e-84 264.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TTB9@28211|Alphaproteobacteria,4BT9B@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Carboxyl transferase domain - - - - - - - - - - - - Carboxyl_trans k59_469952_1 1198232.CYCME_0392 4.56e-88 270.0 COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,1RNZF@1236|Gammaproteobacteria,4613M@72273|Thiotrichales 72273|Thiotrichales S Sodium Bile acid symporter family - - - ko:K03453 - - - - ko00000 2.A.28 - - SBF k59_1555337_2 1177928.TH2_13464 6.96e-20 85.1 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2UBZ6@28211|Alphaproteobacteria,2JT97@204441|Rhodospirillales 204441|Rhodospirillales U Preprotein translocase subunit YajC yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_469967_1 580340.Tlie_1698 5.41e-41 149.0 COG2515@1|root,COG2515@2|Bacteria,3TB8Y@508458|Synergistetes 508458|Synergistetes E Pyridoxal-phosphate dependent enzyme - - 4.4.1.15 ko:K05396 ko00270,map00270 - R01874 RC00382 ko00000,ko00001,ko01000 - - - PALP k59_882802_1 1165096.ARWF01000001_gene645 9.13e-45 152.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2VJRD@28216|Betaproteobacteria,2KM96@206350|Nitrosomonadales 206350|Nitrosomonadales F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_882802_2 1121921.KB898708_gene1446 5.96e-21 92.4 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,2PNBE@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008653,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1903509 - ko:K19804 - - - - ko00000 - - - TPR_16,TPR_19,TPR_7,TPR_8 k59_882816_1 278963.ATWD01000001_gene3860 7.83e-30 117.0 COG1043@1|root,COG1043@2|Bacteria,3Y33C@57723|Acidobacteria,2JI06@204432|Acidobacteriia 204432|Acidobacteriia M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_415830_1 243233.MCA2312 7.35e-81 254.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1XEQ5@135618|Methylococcales 135618|Methylococcales H Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_1039224_1 1469245.JFBG01000086_gene1608 1.03e-107 333.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,1RN40@1236|Gammaproteobacteria,1X2WW@135613|Chromatiales 1236|Gammaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain yagR GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016903,GO:0030151,GO:0033554,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114 1.17.1.4 ko:K11177 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_200929_1 1318628.MARLIPOL_03375 1.58e-42 150.0 COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria,1S5IS@1236|Gammaproteobacteria,46B06@72275|Alteromonadaceae 1236|Gammaproteobacteria D sister chromatid segregation - - - - - - - - - - - - - k59_986611_1 1244869.H261_23117 1.95e-150 434.0 COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,2U1XW@28211|Alphaproteobacteria,2JS0E@204441|Rhodospirillales 204441|Rhodospirillales L transposase, IS204 IS1001 IS1096 IS1165 family protein - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_1193011_1 335543.Sfum_2075 1.25e-139 413.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2MQ5R@213462|Syntrophobacterales 28221|Deltaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1276 CTP_synth_N,GATase k59_156346_2 1057002.KB905370_gene3674 1.13e-204 604.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,4BB6Z@82115|Rhizobiaceae 28211|Alphaproteobacteria P cation efflux system protein (Heavy metal efflux pump) - - - - - - - - - - - - ACR_tran k59_1039231_1 159749.E7BWK0 2.04e-104 327.0 COG0653@1|root,2QS7I@2759|Eukaryota,2XADP@2836|Bacillariophyta 2759|Eukaryota U Protein translocase subunit secA secA - - - - - - - - - - - SecA_DEAD,SecA_PP_bind,SecA_SW k59_1039232_1 536019.Mesop_2090 7.27e-13 75.5 COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,2TRT8@28211|Alphaproteobacteria,43KFD@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I PFAM Acyltransferase - - - - - - - - - - - - Acyl_transf_3 k59_200947_1 690850.Desaf_0269 2.01e-05 45.4 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,42PF5@68525|delta/epsilon subdivisions,2WMD8@28221|Deltaproteobacteria,2M90G@213115|Desulfovibrionales 28221|Deltaproteobacteria C Belongs to the WrbA family wrbA GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - iAF987.Gmet_0771 FMN_red k59_200947_2 1408322.JHYK01000009_gene2254 6.01e-23 96.7 COG0778@1|root,COG0778@2|Bacteria,1V0Y6@1239|Firmicutes,24HMV@186801|Clostridia,27MVQ@186928|unclassified Lachnospiraceae 186801|Clostridia C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_1193034_1 1229909.NSED_02415 5.25e-59 187.0 COG1392@1|root,arCOG02640@2157|Archaea,41SKJ@651137|Thaumarchaeota 651137|Thaumarchaeota P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_1349248_1 1206741.BAFX01000017_gene7217 5.56e-10 57.4 COG1545@1|root,COG1545@2|Bacteria,2IFQP@201174|Actinobacteria,4G0JI@85025|Nocardiaceae 201174|Actinobacteria S DUF35 OB-fold domain, acyl-CoA-associated - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_1349248_2 2002.JOEQ01000052_gene8358 3.95e-89 273.0 COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria,4EH8Z@85012|Streptosporangiales 201174|Actinobacteria I Belongs to the thiolase family - - - - - - - - - - - - Thiolase_N,ketoacyl-synt k59_415871_1 504472.Slin_5606 5.45e-05 51.2 COG0421@1|root,COG4262@1|root,COG0421@2|Bacteria,COG4262@2|Bacteria,4PJAE@976|Bacteroidetes,47MTD@768503|Cytophagia 976|Bacteroidetes E Spermine/spermidine synthase domain - - - - - - - - - - - - Spermine_synth k59_882851_1 656024.FsymDg_3104 2.1e-57 191.0 COG0111@1|root,COG0111@2|Bacteria,2GP09@201174|Actinobacteria 201174|Actinobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase - - - - - - - - - - - - 2-Hacid_dh_C k59_156372_1 1458357.BG58_18420 1.78e-38 143.0 COG3386@1|root,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity araB - - ko:K14274 ko00040,map00040 - R02427 RC00713 ko00000,ko00001,ko01000 - - - HTH_IclR,IclR,SGL,adh_short k59_156372_2 640511.BC1002_6161 1.75e-13 70.5 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2VP3I@28216|Betaproteobacteria,1K3X7@119060|Burkholderiaceae 28216|Betaproteobacteria Q PFAM amidohydrolase - - - - - - - - - - - - Amidohydro_1 k59_22639_1 96561.Dole_0474 1.94e-54 181.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,42M3Y@68525|delta/epsilon subdivisions,2WJH5@28221|Deltaproteobacteria,2MJCG@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_200973_1 314285.KT71_01220 1.42e-108 323.0 COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria,1J9CZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L leucine-zipper of insertion element IS481 - - - ko:K07497 - - - - ko00000 - - - HTH_32,LZ_Tnp_IS481,rve,rve_3 k59_415878_2 1122962.AULH01000001_gene1573 5.44e-09 57.0 COG1171@1|root,COG1171@2|Bacteria,1QTY3@1224|Proteobacteria,2VEUV@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Diaminopropionate ammonia-lyase - - 4.3.1.15 ko:K01751 - - - - ko00000,ko01000 - - - PALP k59_156375_1 1286093.C266_06339 1.08e-107 322.0 COG4521@1|root,COG4521@2|Bacteria,1MVH2@1224|Proteobacteria,2VINJ@28216|Betaproteobacteria,1JZVK@119060|Burkholderiaceae 28216|Betaproteobacteria P taurine ABC transporter tauA - - ko:K15551 ko00920,ko02010,map00920,map02010 M00435 - - ko00000,ko00001,ko00002,ko02000 3.A.1.17.1,3.A.1.17.4 - - NMT1,NMT1_2 k59_200974_1 1499967.BAYZ01000028_gene1308 1.15e-99 295.0 COG0411@1|root,COG0411@2|Bacteria,2NNYG@2323|unclassified Bacteria 2|Bacteria E Branched-chain amino acid ATP-binding cassette transporter livG - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_1349264_2 981384.AEYW01000003_gene2002 7.36e-17 79.7 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4ND0W@97050|Ruegeria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_939774_2 1537994.JQFW01000015_gene1436 2e-121 366.0 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,4640D@72275|Alteromonadaceae 1236|Gammaproteobacteria M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella mltF2 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_1096243_1 697282.Mettu_3497 3.21e-71 224.0 COG0656@1|root,COG0656@2|Bacteria,1MWFS@1224|Proteobacteria,1RMX6@1236|Gammaproteobacteria,1XE6X@135618|Methylococcales 135618|Methylococcales S aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_623047_1 1288826.MSNKSG1_01783 1.39e-63 211.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,465TI@72275|Alteromonadaceae 1236|Gammaproteobacteria KLT COG0515 Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,Pkinase k59_470063_1 1469245.JFBG01000006_gene1602 6.67e-26 105.0 COG2913@1|root,COG2913@2|Bacteria 2|Bacteria J Gram-negative-bacterium-type cell outer membrane assembly bamE - - ko:K06186 - - - - ko00000,ko02000 1.B.33.1 - - SmpA_OmlA k59_470063_2 1333856.L686_19630 1.64e-23 100.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1Z02Z@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L May be involved in recombinational repair of damaged DNA recN GO:0000724,GO:0000725,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_986682_1 1229909.NSED_03115 9.9e-15 69.7 arCOG05400@1|root,arCOG05400@2157|Archaea,41SQH@651137|Thaumarchaeota 651137|Thaumarchaeota S PFAM Polyketide cyclase dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 k59_986682_2 436308.Nmar_0595 1.23e-73 232.0 COG1215@1|root,arCOG01389@2157|Archaea 2157|Archaea M PFAM Glycosyl transferase family 2 - - - ko:K07011,ko:K11936 ko02026,map02026 - - - ko00000,ko00001,ko01000,ko01003,ko02000 4.D.1.1.2,4.D.1.1.3 GT2 - Glyco_tranf_2_3,Glycos_transf_2 k59_156407_1 56780.SYN_00979 6.1e-46 159.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,42MSF@68525|delta/epsilon subdivisions,2WKJ5@28221|Deltaproteobacteria,2MR0H@213462|Syntrophobacterales 28221|Deltaproteobacteria C Alanine dehydrogenase/PNT, N-terminal domain ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - iAF987.Gmet_1099 AlaDh_PNT_C,AlaDh_PNT_N k59_1404631_1 1005048.CFU_0726 6.77e-26 107.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,4724B@75682|Oxalobacteraceae 28216|Betaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1193115_1 204669.Acid345_4432 1.04e-36 141.0 COG2203@1|root,COG2206@1|root,COG3437@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3437@2|Bacteria,3Y61X@57723|Acidobacteria 57723|Acidobacteria T HD domain - - - - - - - - - - - - GAF,HD_5 k59_415923_3 1207063.P24_01630 4.35e-88 270.0 COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,2U5MK@28211|Alphaproteobacteria,2JSM2@204441|Rhodospirillales 204441|Rhodospirillales S Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos k59_415923_4 1205680.CAKO01000037_gene1262 3.21e-36 134.0 COG3639@1|root,COG3639@2|Bacteria,1MW4F@1224|Proteobacteria,2TTXJ@28211|Alphaproteobacteria,2JQT0@204441|Rhodospirillales 204441|Rhodospirillales P COG3639 ABC-type phosphate phosphonate transport system, permease component - - - - - - - - - - - - BPD_transp_1 k59_1404655_1 1120949.KB903358_gene5264 1.65e-43 161.0 COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria,4DBHN@85008|Micromonosporales 201174|Actinobacteria S PFAM peptidase S45 penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_986713_2 1229909.NSED_02845 4.41e-59 190.0 COG0500@1|root,arCOG01631@2157|Archaea,41TBE@651137|Thaumarchaeota 2157|Archaea Q RNA methylase - - - - - - - - - - - - - k59_415942_1 593105.S7A_07065 1.08e-20 91.3 COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,1RP7G@1236|Gammaproteobacteria,3VYN4@53335|Pantoea 1236|Gammaproteobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006139,GO:0006629,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008460,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046379,GO:0046483,GO:0048037,GO:0050662,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576,GO:1903509 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_01936,iECBD_1354.ECBD_1614,iECB_1328.ECB_01947,iECD_1391.ECD_01947,iECIAI39_1322.ECIAI39_0974,iECO26_1355.ECO26_2952,iECSF_1327.ECSF_1930 GDP_Man_Dehyd k59_415942_2 472759.Nhal_0594 1.99e-66 210.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,1WWE2@135613|Chromatiales 135613|Chromatiales G Inositol monophosphatase - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_201043_1 338966.Ppro_2189 6.8e-09 56.2 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WIS3@28221|Deltaproteobacteria,43TQ7@69541|Desulfuromonadales 28221|Deltaproteobacteria H PFAM aminotransferase, class I and II aspB - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_201043_2 330214.NIDE2566 9.65e-61 192.0 COG0669@1|root,COG0669@2|Bacteria,3J0MF@40117|Nitrospirae 40117|Nitrospirae F Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_201043_3 227086.JGI_V11_145769 1.14e-15 82.0 COG0742@1|root,2QSWU@2759|Eukaryota 2759|Eukaryota L Conserved hypothetical protein 95 - - - - - - - - - - - - Cons_hypoth95 k59_1555507_1 1219035.NT2_01_06850 2.83e-23 92.8 COG1545@1|root,COG1545@2|Bacteria,1RIV9@1224|Proteobacteria,2USGC@28211|Alphaproteobacteria,2K4P3@204457|Sphingomonadales 204457|Sphingomonadales S Rubredoxin-like zinc ribbon domain (DUF35_N) - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_415946_1 323261.Noc_1365 1.68e-82 255.0 COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,1RNZF@1236|Gammaproteobacteria,1WXRH@135613|Chromatiales 135613|Chromatiales S PFAM Bile acid sodium symporter - - - ko:K03453 - - - - ko00000 2.A.28 - - SBF k59_1349350_1 1137799.GZ78_07680 1.68e-107 321.0 COG0183@1|root,COG0183@2|Bacteria,1NSYR@1224|Proteobacteria,1SJW4@1236|Gammaproteobacteria,1XR8M@135619|Oceanospirillales 135619|Oceanospirillales I Belongs to the thiolase family - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_882921_1 107635.AZUO01000003_gene4133 7.26e-71 235.0 COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,2TVN2@28211|Alphaproteobacteria 28211|Alphaproteobacteria HP TIGRFAM molybdenum cofactor synthesis domain MA20_10225 - 2.10.1.1 ko:K03750,ko:K07219 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N,PBP_like k59_1193163_1 742735.HMPREF9467_02668 1.57e-13 75.5 COG0248@1|root,COG0248@2|Bacteria,1TS3I@1239|Firmicutes,248EW@186801|Clostridia,21XFZ@1506553|Lachnoclostridium 186801|Clostridia FP Ppx/GppA phosphatase family ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - HD,Ppx-GppA k59_781387_1 347834.RHE_CH00755 4.71e-50 182.0 COG0500@1|root,COG1216@1|root,COG1216@2|Bacteria,COG2226@2|Bacteria,1N3TN@1224|Proteobacteria 1224|Proteobacteria Q Pfam Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_24487_1 304371.MCP_1266 4.75e-69 232.0 COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,2N97B@224756|Methanomicrobia 224756|Methanomicrobia G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1614156_1 309807.SRU_2672 8.93e-09 61.6 COG1668@1|root,COG1668@2|Bacteria,4NFSZ@976|Bacteroidetes,1FIJ8@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes CP ABC-2 family transporter protein natB - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_207714_1 1229909.NSED_00850 8.36e-24 95.9 arCOG08023@1|root,arCOG08023@2157|Archaea,41SKK@651137|Thaumarchaeota 651137|Thaumarchaeota S Zinc finger domain - - - - - - - - - - - - zinc_ribbon_2 k59_207714_2 1229909.NSED_00845 5.45e-63 199.0 COG0681@1|root,arCOG01739@2157|Archaea,41SQ2@651137|Thaumarchaeota 651137|Thaumarchaeota U Signal peptidase - - 3.4.21.89 ko:K13280 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 k59_1562249_1 667014.Thein_1918 2.56e-43 157.0 COG0028@1|root,COG0028@2|Bacteria,2GHEM@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_573671_1 977880.RALTA_B1630 5.67e-96 300.0 COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,2VI36@28216|Betaproteobacteria,1K2J2@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM Isocitrate dehydrogenase NADP-dependent monomeric type icd2 - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_1614178_1 330214.NIDE0192 3.85e-114 333.0 COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae 2|Bacteria S Evidence 4 Homologs of previously reported genes of - - 1.14.99.50 ko:K18912 ko00340,map00340 - R11013 RC03323,RC03324 ko00000,ko00001,ko01000 - - - FGE-sulfatase,Pkinase k59_1354172_2 228410.NE1158 6.08e-58 184.0 COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,2VQ39@28216|Betaproteobacteria,372JP@32003|Nitrosomonadales 28216|Betaproteobacteria F Nudix hydrolase nudC_1 - - - - - - - - - - - NUDIX,Nudix_N_2 k59_207773_1 1379270.AUXF01000002_gene1186 3.66e-79 253.0 COG0706@1|root,COG0706@2|Bacteria,1ZSKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_1562282_1 436308.Nmar_0445 7.89e-103 321.0 COG1196@1|root,arCOG00371@2157|Archaea,41T1Y@651137|Thaumarchaeota 651137|Thaumarchaeota D Required for chromosome condensation and partitioning - - - - - - - - - - - - - k59_207797_1 1123257.AUFV01000008_gene686 9.04e-86 267.0 COG0342@1|root,COG0342@2|Bacteria,1MVFS@1224|Proteobacteria,1RYCF@1236|Gammaproteobacteria,1X5DG@135614|Xanthomonadales 135614|Xanthomonadales U Glutamate-cysteine ligase - - - - - - - - - - - - GshA k59_1562303_1 479434.Sthe_1231 3.09e-31 124.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_1562303_2 935548.KI912159_gene5420 1.97e-160 469.0 COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,1QU5X@1224|Proteobacteria,2TW12@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - Abhydrolase_1,Guanylate_cyc k59_1562303_3 1437824.BN940_07616 1.15e-92 285.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VI2K@28216|Betaproteobacteria,3T2AZ@506|Alcaligenaceae 28216|Betaproteobacteria E Cys/Met metabolism PLP-dependent enzyme mdeA_1 - 2.5.1.48,2.5.1.49 ko:K01739,ko:K01740 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00999,R01287,R01288,R02508,R03217,R03260,R04859,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00420,RC02821,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_886741_1 1397666.RS24_01417 3.2e-39 144.0 COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,4BRMP@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S MmgE/PrpD family MA20_23745 - - - - - - - - - - - MmgE_PrpD k59_207839_1 388051.AUFE01000002_gene495 7.47e-88 276.0 COG0028@1|root,COG0028@2|Bacteria,1MWUB@1224|Proteobacteria,2VMC1@28216|Betaproteobacteria,1K2XV@119060|Burkholderiaceae 28216|Betaproteobacteria EH Belongs to the TPP enzyme family xsc - 2.3.3.15 ko:K03852 ko00430,map00430 - R05651 RC02903,RC02909 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1614215_2 1131813.AQVT01000001_gene2141 8.81e-20 91.7 COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1MVH7@1224|Proteobacteria,2TRNA@28211|Alphaproteobacteria,1JR05@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM DNA methylase N-4 N-6 domain protein - - - - - - - - - - - - N6_N4_Mtase,ParBc k59_886761_1 290397.Adeh_1904 5.43e-10 64.7 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,42R3H@68525|delta/epsilon subdivisions,2WMNY@28221|Deltaproteobacteria,2YUZU@29|Myxococcales 28221|Deltaproteobacteria D NUBPL iron-transfer P-loop NTPase - - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,CbiA,HTH_25,ParA k59_573730_1 436308.Nmar_1309 5.93e-128 383.0 COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S7I@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18594 ko00720,ko01120,map00720,map01120 - R03157 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_1354230_1 1167006.UWK_00111 2.31e-70 223.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,42PS4@68525|delta/epsilon subdivisions,2WM4V@28221|Deltaproteobacteria,2MJ3B@213118|Desulfobacterales 28221|Deltaproteobacteria S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_886773_1 1121920.AUAU01000005_gene1109 6.78e-13 69.3 COG1228@1|root,COG1228@2|Bacteria,3Y47R@57723|Acidobacteria 57723|Acidobacteria Q PFAM amidohydrolase - - - - - - - - - - - - Amidohydro_1 k59_886773_2 566466.NOR53_631 1e-47 167.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,1J5ZV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2303 Choline dehydrogenase and related flavoproteins - - 1.1.99.3 ko:K06151 ko00030,ko01100,ko01120,map00030,map01100,map01120 - R01741 RC00084 ko00000,ko00001,ko01000 - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_207865_1 911045.PSE_1904 6.64e-17 75.1 COG5470@1|root,COG5470@2|Bacteria,1N7JA@1224|Proteobacteria,2UBQW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF1330) MA20_24570 - - - - - - - - - - - DUF1330 k59_207865_2 1123060.JONP01000024_gene2506 1.57e-36 136.0 COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria 28211|Alphaproteobacteria S MmgE PrpD family protein - - - - - - - - - - - - MmgE_PrpD k59_1043192_1 240302.BN982_00199 8.48e-22 95.9 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,4H9YP@91061|Bacilli 91061|Bacilli L SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N k59_1043192_2 279280.Q6J1P7_9CAUD 1.87e-19 87.0 4QBET@10239|Viruses,4QVSW@35237|dsDNA viruses no RNA stage,4QQ0K@28883|Caudovirales,4QNKF@10744|Podoviridae 10744|Podoviridae S hydrolase activity, acting on ester bonds - - - - - - - - - - - - - k59_1562389_1 471853.Bcav_3572 2.23e-14 75.5 COG2182@1|root,COG2182@2|Bacteria,2I2J8@201174|Actinobacteria 201174|Actinobacteria G Extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 k59_1562389_2 1095767.CAHD01000027_gene1648 3.73e-35 132.0 COG1175@1|root,COG1175@2|Bacteria,2GKBJ@201174|Actinobacteria 201174|Actinobacteria G PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_886800_2 886293.Sinac_0637 2.34e-66 211.0 COG1215@1|root,COG1215@2|Bacteria,2IXXE@203682|Planctomycetes 203682|Planctomycetes M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_781574_1 1121949.AQXT01000002_gene2910 1.81e-17 81.3 COG4319@1|root,COG4319@2|Bacteria,1PZUG@1224|Proteobacteria,2V19B@28211|Alphaproteobacteria,44001@69657|Hyphomonadaceae 28211|Alphaproteobacteria S SnoaL-like domain - - - - - - - - - - - - DUF4440 k59_207910_1 1101189.AQUO01000002_gene28 3.56e-86 271.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2PY4Z@265|Paracoccus 28211|Alphaproteobacteria C Aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_1198201_2 768670.Calni_0340 6.19e-34 135.0 COG2067@1|root,COG2067@2|Bacteria,2GFPR@200930|Deferribacteres 200930|Deferribacteres I PFAM membrane protein involved in aromatic hydrocarbon degradation - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_260697_1 472759.Nhal_3848 1.52e-67 218.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,1WWAB@135613|Chromatiales 135613|Chromatiales U Type II secretion system - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_260707_1 95619.PM1_0212535 4.15e-76 245.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_781587_1 319224.Sputcn32_2948 6.25e-100 299.0 COG3673@1|root,COG3673@2|Bacteria,1NFRW@1224|Proteobacteria,1RP20@1236|Gammaproteobacteria,2QB7G@267890|Shewanellaceae 1236|Gammaproteobacteria S Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - - - - - - - - - - DUF2235,PilZ k59_1562441_1 1189612.A33Q_3001 1.13e-07 48.5 2EGPU@1|root,33AFZ@2|Bacteria,4NXYH@976|Bacteroidetes,47S90@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1562441_2 324925.Ppha_0455 3.8e-33 115.0 COG1598@1|root,COG1598@2|Bacteria 2|Bacteria N PFAM Uncharacterised protein family UPF0150 - - - - - - - - - - - - HicB_lk_antitox k59_207936_1 1123376.AUIU01000011_gene902 1.55e-48 169.0 COG3659@1|root,COG3659@2|Bacteria 2|Bacteria M wide pore channel activity - - - ko:K07267 - - - - ko00000,ko02000 1.B.19.1 - - OprB,SLH k59_207969_1 756272.Plabr_1098 1.6e-14 70.1 COG0776@1|root,COG0776@2|Bacteria,2J0XR@203682|Planctomycetes 203682|Planctomycetes L Belongs to the bacterial histone-like protein family - - - - - - - - - - - - Bac_DNA_binding k59_207969_2 177437.HRM2_15540 7.47e-13 68.6 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,42MP3@68525|delta/epsilon subdivisions,2WJ7Y@28221|Deltaproteobacteria,2MIHW@213118|Desulfobacterales 28221|Deltaproteobacteria O Protein of unknown function, DUF255 yyaL - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_260735_1 272562.CA_C1674 1.47e-59 200.0 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,2490X@186801|Clostridia,36EKI@31979|Clostridiaceae 186801|Clostridia C Glutamate synthase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_1562511_1 1408224.SAMCCGM7_c4249 1.15e-57 197.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4BCMT@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc,TPR_16 k59_781650_1 1131553.JIBI01000011_gene728 1.56e-10 65.1 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VTH4@28216|Betaproteobacteria,374AE@32003|Nitrosomonadales 28216|Betaproteobacteria S gag-polyprotein putative aspartyl protease - - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - Asp_protease_2,gag-asp_proteas k59_781650_2 1278306.KB906914_gene1071 0.00036 43.5 COG2096@1|root,COG2096@2|Bacteria,379IZ@32066|Fusobacteria 32066|Fusobacteria S Psort location Cytoplasmic, score - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_573857_1 1229909.NSED_05825 7.63e-11 70.1 arCOG10350@1|root,arCOG10350@2157|Archaea 2157|Archaea C sister chromatid segregation - - - - - - - - - - - - - k59_781656_1 649638.Trad_2205 2.51e-103 313.0 COG0065@1|root,COG0065@2|Bacteria,1WIIS@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_1562560_1 316067.Geob_2695 7.92e-06 51.6 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,42MU5@68525|delta/epsilon subdivisions,2WKWY@28221|Deltaproteobacteria,43UI1@69541|Desulfuromonadales 28221|Deltaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB_C,TruB_C_2,TruB_N k59_781658_1 1229909.NSED_03395 1.34e-74 241.0 COG0018@1|root,arCOG00487@2157|Archaea,41SAI@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_1409793_1 984262.SGRA_3101 1.03e-12 63.9 COG3118@1|root,COG3118@2|Bacteria,4NQ5B@976|Bacteroidetes,1ISZS@117747|Sphingobacteriia 976|Bacteroidetes O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_886925_1 930169.B5T_00858 1.49e-22 94.0 2APBA@1|root,31EDH@2|Bacteria,1RIDJ@1224|Proteobacteria,1S6VZ@1236|Gammaproteobacteria,1XQG4@135619|Oceanospirillales 135619|Oceanospirillales S Putative prokaryotic signal transducing protein - - - - - - - - - - - - DUF2007 k59_886925_2 1306990.BARG01000062_gene7078 2.14e-83 266.0 COG0028@1|root,COG0028@2|Bacteria,2GN3X@201174|Actinobacteria 201174|Actinobacteria EH Belongs to the TPP enzyme family ilvX GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0030312,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_N k59_573894_1 1469245.JFBG01000043_gene1904 5.77e-46 155.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,1WXR9@135613|Chromatiales 1236|Gammaproteobacteria IQ PFAM Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short_C2 k59_573894_2 762376.AXYL_05225 8.86e-78 244.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VHBI@28216|Betaproteobacteria,3T36A@506|Alcaligenaceae 28216|Betaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_886927_1 642227.HA49_15835 1.63e-49 177.0 2DBFB@1|root,2Z8XA@2|Bacteria,1MVTN@1224|Proteobacteria,1RM97@1236|Gammaproteobacteria,4BVDG@82986|Tatumella 1236|Gammaproteobacteria S Protein of unknown function (DUF4056) - - - - - - - - - - - - DUF4056 k59_1409817_1 330214.NIDE3178 2.23e-108 330.0 COG0464@1|root,COG0464@2|Bacteria 2|Bacteria O ATPase activity - - - - - - - - - - - - AAA k59_1354407_1 756272.Plabr_3756 1.52e-69 226.0 COG4146@1|root,COG4146@2|Bacteria,2J1R6@203682|Planctomycetes 203682|Planctomycetes S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_208164_1 1499680.CCFE01000023_gene2364 1.2e-25 108.0 COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,4HJN1@91061|Bacilli,1ZG2C@1386|Bacillus 91061|Bacilli CO alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA k59_1409826_1 436308.Nmar_0572 1.95e-73 233.0 COG1914@1|root,arCOG04531@2157|Archaea 2157|Archaea P COG1914 Mn2 and Fe2 transporters of the NRAMP family - - - - - - - - - - - - 5TM-5TMR_LYT,Nramp k59_38515_1 436308.Nmar_1408 8.36e-44 157.0 COG1389@1|root,arCOG01165@2157|Archaea,41SJ2@651137|Thaumarchaeota 651137|Thaumarchaeota L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6B - 5.99.1.3 ko:K03167 - - - - ko00000,ko01000,ko03032 - - - HATPase_c,Topo-VIb_trans k59_38515_2 436308.Nmar_1407 5.29e-30 115.0 COG1697@1|root,arCOG04143@2157|Archaea,41SQF@651137|Thaumarchaeota 651137|Thaumarchaeota L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6A - 5.99.1.3 ko:K03166 - - - - ko00000,ko01000,ko03032 - - - TP6A_N k59_38550_1 1183438.GKIL_0149 0.000134 44.7 COG2340@1|root,COG2340@2|Bacteria,1G6DK@1117|Cyanobacteria 1117|Cyanobacteria S Cysteine-rich secretory protein family - - - - - - - - - - - - CAP k59_38643_1 1137799.GZ78_22325 1.69e-57 197.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,1XMWY@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_38658_1 436308.Nmar_1320 2.95e-112 346.0 COG1205@1|root,arCOG00555@2157|Archaea,41SZS@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD DEAH box helicase - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C k59_940588_1 1051501.AYTL01000030_gene2200 2.62e-23 103.0 COG2124@1|root,COG2124@2|Bacteria,1TPWZ@1239|Firmicutes,4HAGS@91061|Bacilli,1ZC1Y@1386|Bacillus 91061|Bacilli C Cytochrome P450 - - - - - - - - - - - - p450 k59_888446_1 1123256.KB907926_gene808 9.08e-24 102.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1X479@135614|Xanthomonadales 135614|Xanthomonadales M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) mrcB - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_470442_1 644282.Deba_0812 3.32e-64 207.0 COG1899@1|root,COG1899@2|Bacteria,1R3WQ@1224|Proteobacteria,42M57@68525|delta/epsilon subdivisions,2WJ6N@28221|Deltaproteobacteria 28221|Deltaproteobacteria O peptidyl-lysine modification to peptidyl-hypusine - - - - - - - - - - - - - k59_1149528_1 457398.HMPREF0326_02933 4.62e-21 96.7 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,42NUT@68525|delta/epsilon subdivisions,2WKQX@28221|Deltaproteobacteria,2M80N@213115|Desulfovibrionales 28221|Deltaproteobacteria O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_1149528_2 700598.Niako_6329 4.09e-27 106.0 COG0330@1|root,COG0330@2|Bacteria,4NFPK@976|Bacteroidetes,1IRDU@117747|Sphingobacteriia 976|Bacteroidetes O PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7 k59_418247_1 698769.JFBD01000028_gene1293 4.05e-18 94.7 COG2936@1|root,COG2936@2|Bacteria,1TT0H@1239|Firmicutes,4HC37@91061|Bacilli,4C4UB@84406|Virgibacillus 91061|Bacilli S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_1097299_2 644282.Deba_2368 5.28e-13 66.6 2DP9Z@1|root,3316S@2|Bacteria,1R1CI@1224|Proteobacteria,42V8N@68525|delta/epsilon subdivisions,2X8FK@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_836162_2 1040983.AXAE01000005_gene1823 1.92e-22 91.3 COG0251@1|root,COG0251@2|Bacteria,1RH8Y@1224|Proteobacteria,2U9P4@28211|Alphaproteobacteria,43KD1@69277|Phyllobacteriaceae 28211|Alphaproteobacteria J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_888463_1 1162668.LFE_0114 2.01e-33 120.0 COG0290@1|root,COG0290@2|Bacteria,3J0T0@40117|Nitrospirae 40117|Nitrospirae J Translation initiation factor IF-3, C-terminal domain - - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_888463_2 1026882.MAMP_02697 1.84e-09 54.7 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,4616U@72273|Thiotrichales 72273|Thiotrichales J Belongs to the bacterial ribosomal protein bL35 family rpmI - - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_627308_1 105422.BBPM01000040_gene843 2.93e-38 137.0 COG3145@1|root,COG3145@2|Bacteria,2GNBD@201174|Actinobacteria,2NEFH@228398|Streptacidiphilus 201174|Actinobacteria L 2OG-Fe(II) oxygenase superfamily - - - - - - - - - - - - 2OG-FeII_Oxy_2 k59_1097306_1 1123020.AUIE01000021_gene906 4.17e-15 80.1 COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,1RSJC@1236|Gammaproteobacteria,1YERK@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_1045083_1 1121422.AUMW01000001_gene2466 5.95e-46 159.0 COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,260FR@186807|Peptococcaceae 186801|Clostridia E PFAM DAHP synthetase I aroF1 - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_731681_1 237368.SCABRO_03830 4.12e-57 193.0 COG0671@1|root,COG0671@2|Bacteria,2IZAS@203682|Planctomycetes 203682|Planctomycetes I LssY C-terminus - - - - - - - - - - - - LssY_C k59_470463_1 398580.Dshi_2303 1.93e-12 72.4 COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2TSQ2@28211|Alphaproteobacteria 28211|Alphaproteobacteria P protein involved in response to NO nnrS - - ko:K07234 - - - - ko00000 - - - NnrS k59_992877_2 453591.Igni_0020 4.42e-37 130.0 COG0432@1|root,arCOG04214@2157|Archaea,2XQJZ@28889|Crenarchaeota 28889|Crenarchaeota S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_627326_1 1123400.KB904750_gene643 4.68e-88 264.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1S23B@1236|Gammaproteobacteria,460N7@72273|Thiotrichales 72273|Thiotrichales S Belongs to the WrbA family wrbA - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_731703_1 1157637.KB892135_gene3353 7.57e-18 82.4 COG0160@1|root,COG0160@2|Bacteria,2GKVH@201174|Actinobacteria 201174|Actinobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.19 ko:K00823 ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_731703_2 1122135.KB893134_gene3124 2.82e-71 223.0 COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,2TRRJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E ABC-type spermidine putrescine transport system, permease component II potI - - ko:K11074 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - BPD_transp_1 k59_992880_1 697282.Mettu_0278 1.75e-87 261.0 COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,1RPQV@1236|Gammaproteobacteria,1XEAM@135618|Methylococcales 135618|Methylococcales O C-terminal domain of 1-Cys peroxiredoxin - - - - - - - - - - - - 1-cysPrx_C,AhpC-TSA k59_366148_1 349124.Hhal_2100 6.76e-21 86.7 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,1WYVR@135613|Chromatiales 135613|Chromatiales K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ k59_366148_2 1410619.SRDD_06770 9.94e-24 100.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,4000X@613|Serratia 1236|Gammaproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_627331_1 1207063.P24_09321 9.27e-85 271.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2JPR7@204441|Rhodospirillales 204441|Rhodospirillales I COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit - - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_418288_1 1131553.JIBI01000047_gene1610 9.25e-53 171.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2VK46@28216|Betaproteobacteria,3721J@32003|Nitrosomonadales 28216|Betaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_418288_2 641149.HMPREF9016_01650 4.85e-29 113.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,2KQHP@206351|Neisseriales 206351|Neisseriales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_418290_1 472759.Nhal_0520 2.12e-24 95.5 COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,1S5YH@1236|Gammaproteobacteria,1WYCE@135613|Chromatiales 135613|Chromatiales H PFAM molybdopterin biosynthesis MoaE - - 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE k59_418290_2 396588.Tgr7_2951 1.03e-26 99.8 COG1977@1|root,COG1977@2|Bacteria,1NHG7@1224|Proteobacteria,1TK6F@1236|Gammaproteobacteria,1WZUM@135613|Chromatiales 135613|Chromatiales H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin moaD - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_1201926_2 631362.Thi970DRAFT_03188 9.94e-36 125.0 COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,1S6DA@1236|Gammaproteobacteria,1WYGJ@135613|Chromatiales 135613|Chromatiales L IS66 Orf2 like - - - - - - - - - - - - TnpB_IS66 k59_522759_1 765913.ThidrDRAFT_3542 8.5e-44 164.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales 135613|Chromatiales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_522759_2 1234364.AMSF01000015_gene3249 1.47e-15 78.6 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1X3FV@135614|Xanthomonadales 135614|Xanthomonadales M N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,LysM k59_627356_1 479433.Caci_5356 1.98e-145 422.0 COG1960@1|root,COG1960@2|Bacteria,2ICK3@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_627356_2 479433.Caci_5358 2.4e-39 135.0 COG2030@1|root,COG2030@2|Bacteria,2ICZR@201174|Actinobacteria 201174|Actinobacteria I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydrat_N k59_470497_1 762376.AXYL_02399 5.09e-22 91.7 COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2VMEA@28216|Betaproteobacteria,3T23W@506|Alcaligenaceae 28216|Betaproteobacteria J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins ydaF_2 - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 k59_470497_2 420324.KI912069_gene6356 1.34e-50 166.0 COG1672@1|root,COG1672@2|Bacteria,1N05N@1224|Proteobacteria,2UBUA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Electron transfer DM13 - - - - - - - - - - - - DM13 k59_1410753_1 1123261.AXDW01000018_gene789 1.61e-59 195.0 COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,1RR31@1236|Gammaproteobacteria,1X47R@135614|Xanthomonadales 135614|Xanthomonadales S Zn-dependent hydrolases including glyoxylases - - - - - - - - - - - - Lactamase_B k59_836219_2 933262.AXAM01000222_gene924 6.64e-37 136.0 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2WMQ8@28221|Deltaproteobacteria,2MJAD@213118|Desulfobacterales 28221|Deltaproteobacteria NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue pilD - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_627364_1 1047013.AQSP01000076_gene1470 2.56e-49 169.0 COG3385@1|root,COG3385@2|Bacteria,2NRDU@2323|unclassified Bacteria 2|Bacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_52763_1 1278307.KB906976_gene1564 1.84e-58 204.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RNWM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_627366_1 767434.Fraau_2252 4.02e-05 51.2 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,1RYFT@1236|Gammaproteobacteria,1X3IT@135614|Xanthomonadales 135614|Xanthomonadales EU peptidase - - - - - - - - - - - - PD40,Peptidase_S9 k59_1254094_1 998674.ATTE01000001_gene3824 2.12e-83 259.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,460A1@72273|Thiotrichales 72273|Thiotrichales P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_731735_1 316067.Geob_3485 4.75e-143 412.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,42M1J@68525|delta/epsilon subdivisions,2WIQR@28221|Deltaproteobacteria,43SBN@69541|Desulfuromonadales 28221|Deltaproteobacteria D TIGRFAM cell shape determining protein, MreB Mrl family mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_784072_1 713586.KB900536_gene708 3.65e-14 67.8 COG2009@1|root,COG2009@2|Bacteria,1N8VA@1224|Proteobacteria 1224|Proteobacteria C succinate dehydrogenase - - - ko:K00247 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_784072_2 666684.AfiDRAFT_3078 2.09e-26 102.0 COG2142@1|root,COG2142@2|Bacteria,1MZKE@1224|Proteobacteria,2UDDU@28211|Alphaproteobacteria,3K54K@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C succinate dehydrogenase - - - ko:K00246 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_261636_1 697282.Mettu_3886 2.53e-11 71.2 COG1749@1|root,COG2319@1|root,COG2372@1|root,COG1749@2|Bacteria,COG2319@2|Bacteria,COG2372@2|Bacteria,1MWJA@1224|Proteobacteria,1S1AJ@1236|Gammaproteobacteria,1XF66@135618|Methylococcales 135618|Methylococcales N WD40 repeat, subgroup - - - - - - - - - - - - Big_5,DUF4082,WD40 k59_1306301_1 765914.ThisiDRAFT_2023 7.08e-164 468.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1WW9F@135613|Chromatiales 135613|Chromatiales E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_104896_1 767817.Desgi_2442 1.29e-111 356.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,2605R@186807|Peptococcaceae 186801|Clostridia L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_209376_1 1123269.NX02_17050 2.01e-44 156.0 COG1545@1|root,COG1545@2|Bacteria,1R44D@1224|Proteobacteria,2UQDI@28211|Alphaproteobacteria,2K20P@204457|Sphingomonadales 204457|Sphingomonadales S DUF35 OB-fold domain, acyl-CoA-associated - - - ko:K07068 - - - - ko00000 - - - DUF35_N,MaoC_dehydrat_N,OB_aCoA_assoc k59_313864_1 93220.LV28_16360 6.13e-114 342.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VI77@28216|Betaproteobacteria,1K003@119060|Burkholderiaceae 28216|Betaproteobacteria I carboxylase accB - 6.4.1.4 ko:K01969 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_104900_1 1380387.JADM01000001_gene467 1.63e-95 291.0 COG0451@1|root,COG0451@2|Bacteria,1N8PG@1224|Proteobacteria,1RWCX@1236|Gammaproteobacteria,1XMB1@135619|Oceanospirillales 135619|Oceanospirillales GM COG0451 Nucleoside-diphosphate-sugar epimerases - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_104900_2 1002809.SSIL_2408 2.99e-10 60.5 COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,4H9VR@91061|Bacilli,26DUZ@186818|Planococcaceae 91061|Bacilli E COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_888552_1 322710.Avin_39000 1.92e-126 365.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_1515158_2 1033802.SSPSH_002018 3.9e-36 134.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria 1236|Gammaproteobacteria EQ COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit hyuB - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_1097391_1 1249997.JHZW01000002_gene1835 2.18e-45 167.0 COG0421@1|root,COG0421@2|Bacteria 2|Bacteria E spermidine synthase activity speE GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth k59_522799_2 311402.Avi_5877 0.000202 46.2 COG1028@1|root,COG1028@2|Bacteria,1R6DD@1224|Proteobacteria,2U4GF@28211|Alphaproteobacteria,4BBZR@82115|Rhizobiaceae 28211|Alphaproteobacteria IQ KR domain - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_471140_2 1394178.AWOO02000006_gene3424 4.08e-19 83.6 COG5517@1|root,COG5517@2|Bacteria,2IN5V@201174|Actinobacteria 201174|Actinobacteria Q SnoaL-like domain baiE - - - - - - - - - - - SnoaL_4 k59_1463913_1 768671.ThimaDRAFT_4006 5.5e-80 249.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1WW4A@135613|Chromatiales 135613|Chromatiales I Belongs to the thiolase family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1620623_1 555779.Dthio_PD1650 2.06e-36 140.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria,2M8RK@213115|Desulfovibrionales 28221|Deltaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_1150323_1 926550.CLDAP_14230 4.22e-40 136.0 COG1839@1|root,COG1839@2|Bacteria,2G6BH@200795|Chloroflexi 200795|Chloroflexi S Adenosine specific kinase - - - ko:K09129 - - - - ko00000 - - - Adenosine_kin k59_53825_1 207559.Dde_2531 2.14e-16 78.2 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2WJB0@28221|Deltaproteobacteria,2M97P@213115|Desulfovibrionales 28221|Deltaproteobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_53825_2 589865.DaAHT2_2213 9.53e-54 182.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,42M7Y@68525|delta/epsilon subdivisions,2WIRN@28221|Deltaproteobacteria,2MHTS@213118|Desulfobacterales 28221|Deltaproteobacteria E TIGRFAM argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1,NUDIX k59_1463940_1 1123399.AQVE01000004_gene2626 5.87e-32 125.0 COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,1RMDQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria KLT serine threonine protein kinase pkn3 - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - Pkinase k59_262506_1 436308.Nmar_0307 1.24e-46 150.0 COG1698@1|root,arCOG04308@2157|Archaea,41SRP@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the UPF0147 family - - - ko:K09721 - - - - ko00000 - - - UPF0147 k59_262506_2 395961.Cyan7425_4661 1.93e-06 52.0 COG2890@1|root,COG2890@2|Bacteria,1G51W@1117|Cyanobacteria,3KJXV@43988|Cyanothece 1117|Cyanobacteria J RNA methylase - - - - - - - - - - - - Methyltransf_31 k59_1047066_1 1229909.NSED_02340 8.42e-37 128.0 COG0454@1|root,arCOG00826@2157|Archaea 2157|Archaea K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1 k59_1047066_2 436308.Nmar_0365 2.04e-32 115.0 arCOG08680@1|root,arCOG08680@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_890491_1 1279038.KB907337_gene395 7.79e-08 52.0 COG2938@1|root,COG2938@2|Bacteria,1N6SJ@1224|Proteobacteria,2UFF5@28211|Alphaproteobacteria,2JU8K@204441|Rhodospirillales 204441|Rhodospirillales S Flavinator of succinate dehydrogenase - - - ko:K09159 - - - - ko00000,ko02048 - - - Sdh5 k59_890491_2 411684.HPDFL43_17870 6.06e-44 149.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2TQYF@28211|Alphaproteobacteria,43J2I@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family sdhB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_10,Fer4_17,Fer4_8 k59_1412387_1 161528.ED21_20784 5.09e-25 105.0 28M5H@1|root,2ZAJ9@2|Bacteria,1RJY2@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_733687_1 941449.dsx2_2410 4.93e-154 464.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2M7WE@213115|Desulfovibrionales 28221|Deltaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC pacL - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_1099415_1 269799.Gmet_2506 3.96e-41 147.0 COG0705@1|root,COG0705@2|Bacteria,1N258@1224|Proteobacteria,42UB4@68525|delta/epsilon subdivisions,2WQJ3@28221|Deltaproteobacteria,43U5E@69541|Desulfuromonadales 28221|Deltaproteobacteria S Rhomboid family - - - - - - - - - - - - Rhomboid k59_55131_1 1201290.M902_0312 3.07e-65 223.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Methionine synthase B12-binding module cap domain protein metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_786376_1 187272.Mlg_2601 4.07e-57 191.0 COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,1RPQN@1236|Gammaproteobacteria,1WWIP@135613|Chromatiales 135613|Chromatiales S 2-methylcitrate dehydratase prpD - 4.2.1.79 ko:K01720 ko00640,map00640 - R04424 RC01152 ko00000,ko00001,ko01000 - - - MmgE_PrpD k59_786376_2 1217718.ALOU01000007_gene1311 7.5e-17 79.3 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VHJZ@28216|Betaproteobacteria,1K1TX@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the citrate synthase family prpC - 2.3.3.5 ko:K01659 ko00640,map00640 - R00931 RC00004,RC00406,RC02827 ko00000,ko00001,ko01000 - - - Citrate_synt k59_315884_1 493475.GARC_5248 1.42e-130 390.0 COG0501@1|root,COG0501@2|Bacteria,1MVU4@1224|Proteobacteria,1RPJ5@1236|Gammaproteobacteria,46584@72275|Alteromonadaceae 1236|Gammaproteobacteria O COG0501 Zn-dependent protease with chaperone function htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_524695_1 1255043.TVNIR_2481 1.98e-103 323.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales 135613|Chromatiales O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_629753_1 1266908.AQPB01000033_gene1683 2.14e-47 173.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4 k59_263592_1 396588.Tgr7_2693 2.64e-38 132.0 2AEMZ@1|root,314HW@2|Bacteria,1RHE3@1224|Proteobacteria,1S7P7@1236|Gammaproteobacteria,1WYF1@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_211295_1 118163.Ple7327_4376 1.38e-72 228.0 COG0438@1|root,COG0438@2|Bacteria,1G830@1117|Cyanobacteria,3VKAZ@52604|Pleurocapsales 1117|Cyanobacteria M Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21 k59_315895_1 1123073.KB899242_gene1636 6.11e-14 78.6 COG3975@1|root,COG3975@2|Bacteria,1N69B@1224|Proteobacteria,1RY45@1236|Gammaproteobacteria,1X82A@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_315895_2 555778.Hneap_1706 1.2e-37 128.0 COG0011@1|root,COG0011@2|Bacteria,1N1NM@1224|Proteobacteria,1SAV8@1236|Gammaproteobacteria,1WZPV@135613|Chromatiales 135613|Chromatiales S Thiamine-binding protein - - - - - - - - - - - - Thiamine_BP k59_315895_3 1158338.JNLJ01000001_gene907 1.34e-14 68.6 2DNS1@1|root,32YVX@2|Bacteria,2G4CS@200783|Aquificae 200783|Aquificae S Protein of unknown function (DUF2905) - - - - - - - - - - - - DUF2905 k59_1621715_1 713586.KB900536_gene1070 5.97e-34 122.0 COG1652@1|root,COG1652@2|Bacteria,1NKUE@1224|Proteobacteria,1SW3N@1236|Gammaproteobacteria 1236|Gammaproteobacteria S LysM domain - - - - - - - - - - - - LysM k59_1151341_1 1229909.NSED_01430 2.11e-121 360.0 COG0260@1|root,arCOG04322@2157|Archaea,41SYD@651137|Thaumarchaeota 651137|Thaumarchaeota E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_942338_1 330214.NIDE0987 1.46e-17 79.0 COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,3J0T7@40117|Nitrospirae 40117|Nitrospirae E Phosphoribosyl-AMP cyclohydrolase hisI - 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH,PRA-PH k59_942338_2 682795.AciX8_4439 9.02e-49 158.0 COG0537@1|root,COG0537@2|Bacteria,3Y542@57723|Acidobacteria,2JJT8@204432|Acidobacteriia 204432|Acidobacteriia FG PFAM Histidine triad (HIT) protein - - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_1204324_1 1123228.AUIH01000038_gene2738 1.82e-13 80.1 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1XNUT@135619|Oceanospirillales 135619|Oceanospirillales M RHS Repeat - - - - - - - - - - - - RHS,RHS_repeat k59_1099448_1 330214.NIDE3058 1.48e-164 478.0 COG1222@1|root,COG1222@2|Bacteria 2|Bacteria O protein catabolic process arc GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369 - ko:K13527 ko03050,map03050 M00342 - - ko00000,ko00001,ko00002,ko03051 - - - AAA,Prot_ATP_ID_OB k59_1516412_1 221288.JH992901_gene2647 3.8e-15 71.2 2EP5I@1|root,33GS9@2|Bacteria,1GAN9@1117|Cyanobacteria,1JMDM@1189|Stigonemataceae 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_1516412_2 221288.JH992901_gene2648 2.96e-62 193.0 COG3654@1|root,COG3654@2|Bacteria,1G781@1117|Cyanobacteria,1JJ3W@1189|Stigonemataceae 1117|Cyanobacteria S Fic/DOC family - - - ko:K07341 - - - - ko00000,ko02048 - - - Fic k59_838189_1 187272.Mlg_1900 4.08e-49 176.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1WVW2@135613|Chromatiales 135613|Chromatiales O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_629799_1 686340.Metal_2691 1.21e-73 232.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1XDRI@135618|Methylococcales 135618|Methylococcales I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_1307975_2 391037.Sare_1622 3.77e-64 209.0 COG0517@1|root,COG1125@1|root,COG0517@2|Bacteria,COG1125@2|Bacteria,2GJHI@201174|Actinobacteria,4DHG9@85008|Micromonosporales 201174|Actinobacteria P TIGRFAM glycine betaine L-proline ABC transporter, ATPase subunit - - - ko:K05847 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - ABC_tran,BPD_transp_1,CBS k59_1621737_2 713586.KB900536_gene1088 6.38e-68 219.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_733739_1 666685.R2APBS1_1482 4.95e-46 159.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,1RVJU@1236|Gammaproteobacteria,1XCR6@135614|Xanthomonadales 135614|Xanthomonadales I alpha/beta hydrolase fold - - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_786437_1 589865.DaAHT2_1455 1.91e-67 224.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria,2MIK2@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1307977_1 1343739.PAP_08730 3.46e-25 108.0 COG0577@1|root,arCOG02312@2157|Archaea 2157|Archaea V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_994521_2 330214.NIDE0534 1.17e-93 288.0 COG1641@1|root,COG1641@2|Bacteria 2|Bacteria H Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes larC - 4.99.1.12 ko:K09121 - - - - ko00000,ko01000 - - - DUF111 k59_890548_1 396588.Tgr7_0817 2.74e-138 417.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales 135613|Chromatiales O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_942357_1 400682.PAC_15703144 2.18e-155 450.0 COG0365@1|root,KOG1175@2759|Eukaryota,38BR4@33154|Opisthokonta,3BE2N@33208|Metazoa 33208|Metazoa I acetate-CoA ligase activity - - - - - - - - - - - - ACAS_N,AMP-binding,AMP-binding_C k59_1621741_1 153948.NAL212_2398 5.37e-44 168.0 COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,372V5@32003|Nitrosomonadales 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - EAL,GGDEF,HAMP,LapD_MoxY_N,PAS,PAS_3,PAS_4,PAS_9 k59_1465158_1 414684.RC1_3257 6.48e-115 344.0 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2TR7D@28211|Alphaproteobacteria,2JRC6@204441|Rhodospirillales 204441|Rhodospirillales C CoA-transferase family III - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_1412453_2 867845.KI911784_gene3105 8.9e-26 101.0 COG3703@1|root,COG3703@2|Bacteria 2|Bacteria P gamma-glutamylcyclotransferase activity ykqA - - - - - - - - - - - AIG2_2,GGACT k59_1516431_1 1278309.KB907101_gene378 0.000386 44.7 COG0689@1|root,COG0689@2|Bacteria,1R2KM@1224|Proteobacteria,1T5SB@1236|Gammaproteobacteria,1XNHN@135619|Oceanospirillales 135619|Oceanospirillales J Putative Ig domain - - - - - - - - - - - - He_PIG k59_315938_1 1120934.KB894433_gene6253 2.44e-43 149.0 COG1024@1|root,COG1024@2|Bacteria,2HHR6@201174|Actinobacteria,4DXU9@85010|Pseudonocardiales 201174|Actinobacteria I enoyl-CoA hydratase Echdc - - - - - - - - - - - ECH_1 k59_472132_1 1122609.AUGT01000017_gene828 6.16e-29 125.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.48 ko:K02182 - - - - ko00000,ko01000 - - - AMP-binding,AMP-binding_C k59_1047141_1 1121015.N789_13675 2.3e-12 72.8 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1X3WY@135614|Xanthomonadales 135614|Xanthomonadales M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_D23 k59_1586_1 216594.MMAR_3425 2e-08 56.2 COG1073@1|root,COG1073@2|Bacteria,2I8SP@201174|Actinobacteria,23AD2@1762|Mycobacteriaceae 201174|Actinobacteria S alpha beta - - - - - - - - - - - - - k59_158339_1 349124.Hhal_2363 4.21e-47 166.0 COG0438@1|root,COG0438@2|Bacteria,1PDW1@1224|Proteobacteria,1RZIK@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Capsular polysaccharide biosynthesis protein - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1151382_1 1380394.JADL01000011_gene3911 1.19e-23 99.4 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,2JV59@204441|Rhodospirillales 204441|Rhodospirillales EQ Hydantoinase B/oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_1151382_2 391038.Bphy_2359 1.15e-69 220.0 COG0604@1|root,COG0604@2|Bacteria,1R8NX@1224|Proteobacteria,2W0KY@28216|Betaproteobacteria,1K4PK@119060|Burkholderiaceae 28216|Betaproteobacteria C Alcohol dehydrogenase GroES-like domain - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N_2 k59_1256524_1 189425.PGRAT_31290 1.09e-41 147.0 COG1028@1|root,COG1028@2|Bacteria,1TS27@1239|Firmicutes,4HDAK@91061|Bacilli,26TE6@186822|Paenibacillaceae 91061|Bacilli IQ related to short-chain alcohol - - - - - - - - - - - - adh_short_C2 k59_1570101_1 330214.NIDE0820 3.09e-30 110.0 COG0780@1|root,COG0780@2|Bacteria,3J0R4@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF k59_1570101_2 557598.LHK_00317 4.57e-79 247.0 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,2VHV6@28216|Betaproteobacteria,2KPG2@206351|Neisseriales 206351|Neisseriales T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH - 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - - Metallophos k59_995407_1 443254.Marpi_0834 8.6e-05 47.0 COG1175@1|root,COG1175@2|Bacteria,2GCAQ@200918|Thermotogae 200918|Thermotogae P PFAM Binding-protein-dependent transport - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_995407_2 1038859.AXAU01000018_gene6727 3.38e-27 109.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,3JQYC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_1413407_1 998674.ATTE01000001_gene2263 6.91e-51 175.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,45ZZH@72273|Thiotrichales 72273|Thiotrichales I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_787593_1 1122609.AUGT01000015_gene2084 4.51e-42 151.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4DNZX@85009|Propionibacteriales 201174|Actinobacteria Q Cytochrome P450 - - - - - - - - - - - - p450 k59_1570107_1 637905.SVI_3146 3.93e-17 82.8 COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1SASQ@1236|Gammaproteobacteria,2Q9NP@267890|Shewanellaceae 1236|Gammaproteobacteria K PFAM sigma-70 region 2 domain protein - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_630971_1 1380354.JIAN01000005_gene2849 3.3e-43 145.0 COG0853@1|root,COG0853@2|Bacteria,2IHTC@201174|Actinobacteria,4F18V@85016|Cellulomonadaceae 201174|Actinobacteria H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD GO:0003674,GO:0003824,GO:0004068,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006523,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0030312,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox k59_630971_2 1123321.KB905824_gene4359 2.27e-44 150.0 COG0691@1|root,COG0691@2|Bacteria,2GJX1@201174|Actinobacteria 201174|Actinobacteria O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03664 - - - - ko00000 - - - SmpB k59_264588_1 330214.NIDE0956 8.4e-07 52.0 COG4122@1|root,COG4122@2|Bacteria,3J0ZW@40117|Nitrospirae 40117|Nitrospirae S Pup-ligase protein - - 3.5.1.119 ko:K20814 - - - - ko00000,ko01000,ko03051 - - - Pup_ligase k59_264588_2 330214.NIDE0955 2.26e-40 147.0 COG1222@1|root,COG1222@2|Bacteria,3J0Z7@40117|Nitrospirae 40117|Nitrospirae O Proteasomal ATPase OB/ID domain - - - ko:K13527 ko03050,map03050 M00342 - - ko00000,ko00001,ko00002,ko03051 - - - AAA,Prot_ATP_ID_OB k59_1413418_1 795666.MW7_0563 9.69e-38 139.0 COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHMW@28216|Betaproteobacteria,1K1ZC@119060|Burkholderiaceae 28216|Betaproteobacteria KLT Serine threonine protein kinase spkD - - - - - - - - - - - Pkinase k59_683163_1 439235.Dalk_3236 2.39e-19 90.5 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,42M1B@68525|delta/epsilon subdivisions,2WK2M@28221|Deltaproteobacteria,2MJ27@213118|Desulfobacterales 28221|Deltaproteobacteria H Belongs to the FPP GGPP synthase family ispB - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 ko:K02523,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061,R09248 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_525641_1 1122194.AUHU01000014_gene1134 4.7e-05 47.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,464WA@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG1519 3-deoxy-D-manno-octulosonic-acid transferase waaA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 iECNA114_1301.ECNA114_3778,iUMNK88_1353.UMNK88_4417 Glycos_transf_1,Glycos_transf_N k59_369113_1 1101190.ARWB01000001_gene1273 1.01e-07 59.3 COG3659@1|root,COG3659@2|Bacteria,1QMC3@1224|Proteobacteria,2TU5Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria M PFAM Carbohydrate-selective porin OprB - - - ko:K07267 - - - - ko00000,ko02000 1.B.19.1 - - OprB k59_56357_1 1030157.AFMP01000009_gene3656 9.2e-128 386.0 COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1QV6D@1224|Proteobacteria,2TTB1@28211|Alphaproteobacteria,2K8G7@204457|Sphingomonadales 204457|Sphingomonadales I 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III - - - - - - - - - - - - - k59_56357_2 404589.Anae109_4390 1.12e-282 793.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJZ3@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_56357_3 1160137.KB907307_gene3904 3.47e-72 226.0 COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria,4FU5R@85025|Nocardiaceae 201174|Actinobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_1100446_2 640081.Dsui_2110 3.58e-106 320.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2VP05@28216|Betaproteobacteria 28216|Betaproteobacteria L transposase IS116 IS110 IS902 family protein - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_1622690_1 1452718.JBOY01000023_gene328 2e-97 320.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase morA - - - - - - - - - - - EAL,GGDEF,PAS,PAS_8,PAS_9,dCache_2 k59_421300_1 1047013.AQSP01000121_gene2703 6.59e-18 78.2 2DMHR@1|root,32RMI@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_943318_1 518766.Rmar_2016 4.32e-54 181.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - nosY - - ko:K19341 ko02010,map02010 M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1.132.2 - - ABC2_membrane_2 k59_839189_1 491952.Mar181_1625 3.42e-46 164.0 COG2195@1|root,COG2195@2|Bacteria,1MUWK@1224|Proteobacteria,1RP5F@1236|Gammaproteobacteria,1XH2X@135619|Oceanospirillales 135619|Oceanospirillales E aminoacyl-histidine dipeptidase pepD - - ko:K01270 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_734692_1 1144275.COCOR_01156 7.16e-07 52.4 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YU4M@29|Myxococcales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family sasR - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_734692_2 1219035.NT2_01_01600 1.07e-55 185.0 COG2141@1|root,COG2141@2|Bacteria,1MWDV@1224|Proteobacteria,2TV51@28211|Alphaproteobacteria,2K2AV@204457|Sphingomonadales 204457|Sphingomonadales C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_107474_1 1411123.JQNH01000001_gene3783 1.46e-15 81.3 COG4485@1|root,COG4485@2|Bacteria,1NBM0@1224|Proteobacteria,2U1FH@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Bacterial membrane protein, YfhO - - - - - - - - - - - - - k59_787653_1 1123392.AQWL01000007_gene882 9.71e-69 221.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VKS0@28216|Betaproteobacteria 28216|Betaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_734697_1 436308.Nmar_1772 8.79e-170 483.0 COG1509@1|root,arCOG03246@2157|Archaea,41SY6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM lysine 2,3-aminomutase YodO family protein - - - - - - - - - - - - - k59_1205601_1 290397.Adeh_2976 8.24e-92 285.0 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,42MN2@68525|delta/epsilon subdivisions,2WIMJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria C cluster binding protein - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_421320_1 234267.Acid_2211 1.9e-34 137.0 COG0624@1|root,COG0624@2|Bacteria,3Y4G2@57723|Acidobacteria 57723|Acidobacteria E peptidase dimerisation domain protein - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_525683_1 203122.Sde_1170 6.27e-79 244.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,465BH@72275|Alteromonadaceae 1236|Gammaproteobacteria V COG1131 ABC-type multidrug transport system, ATPase component yadG GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_473125_1 1260251.SPISAL_06565 1.25e-179 517.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1WW7K@135613|Chromatiales 135613|Chromatiales T GTP-binding protein TypA - - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_212327_1 272123.Anacy_4870 2.67e-28 119.0 COG0517@1|root,COG2202@1|root,COG2203@1|root,COG3829@1|root,COG5002@1|root,COG0517@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1GHCI@1117|Cyanobacteria,1HTRD@1161|Nostocales 1117|Cyanobacteria T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CBS,CheB_methylest,CheR,CheR_N,GAF,GAF_2,GGDEF,HATPase_c,HisKA,PAS,PAS_10,PAS_3,PAS_4,PAS_8,PAS_9 k59_1982_1 331869.BAL199_24589 1.21e-40 152.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria 28211|Alphaproteobacteria E gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_943339_1 1128912.GMES_2836 5.29e-05 50.8 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,1RTRD@1236|Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_683226_1 999541.bgla_1g00480 8.12e-15 76.6 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2VI7X@28216|Betaproteobacteria,1K1ZV@119060|Burkholderiaceae 28216|Betaproteobacteria NU general secretion pathway protein D gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_683226_2 713586.KB900536_gene2363 2.11e-11 65.9 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WX5F@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1205613_1 1415778.JQMM01000001_gene990 5.19e-77 243.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1J55X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1466219_1 404589.Anae109_0502 4.38e-26 107.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2YXS2@29|Myxococcales 28221|Deltaproteobacteria C Malic enzyme, NAD binding domain maeB - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1637 Malic_M,PTA_PTB,malic k59_891596_1 311402.Avi_5404 4.86e-06 52.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TS9K@28211|Alphaproteobacteria,4BM66@82115|Rhizobiaceae 28211|Alphaproteobacteria P ATPases associated with a variety of cellular activities - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_1570171_1 40492.XP_007304989.1 7.47e-46 160.0 COG0722@1|root,2QPSU@2759|Eukaryota,38CAA@33154|Opisthokonta,3NVDJ@4751|Fungi,3UYDF@5204|Basidiomycota,2282D@155619|Agaricomycetes,3H1HP@355688|Agaricomycetes incertae sedis 4751|Fungi E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) - - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_159054_1 1121403.AUCV01000003_gene1775 6.17e-06 57.8 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MIJD@213118|Desulfobacterales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_631072_1 1249627.D779_4060 1.52e-73 241.0 COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,1SX9U@1236|Gammaproteobacteria,1X0R6@135613|Chromatiales 135613|Chromatiales U Predicted Permease Membrane Region - - - - - - - - - - - - Asp-Al_Ex,TrkA_C k59_473156_1 760192.Halhy_0869 2.85e-50 173.0 COG3268@1|root,COG3268@2|Bacteria,4NM0F@976|Bacteroidetes,1IY56@117747|Sphingobacteriia 976|Bacteroidetes C Saccharopine dehydrogenase NADP binding domain - - - - - - - - - - - - Sacchrp_dh_NADP k59_56446_1 637389.Acaty_c1653 3.44e-59 188.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,2NCAC@225057|Acidithiobacillales 225057|Acidithiobacillales J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_107523_1 396588.Tgr7_1533 9.62e-60 193.0 COG3264@1|root,COG3264@2|Bacteria,1QUBW@1224|Proteobacteria,1T1SF@1236|Gammaproteobacteria,1WY8X@135613|Chromatiales 135613|Chromatiales M mechanosensitive ion channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix k59_1152399_1 1038859.AXAU01000015_gene937 4.8e-40 151.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVRF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_1152399_2 404380.Gbem_3311 1.03e-127 372.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,42PGW@68525|delta/epsilon subdivisions,2WMMZ@28221|Deltaproteobacteria,43TCD@69541|Desulfuromonadales 28221|Deltaproteobacteria C PFAM Alcohol dehydrogenase zinc-binding domain protein - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_1413508_1 420324.KI912069_gene6356 3.58e-36 129.0 COG1672@1|root,COG1672@2|Bacteria,1N05N@1224|Proteobacteria,2UBUA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Electron transfer DM13 - - - - - - - - - - - - DM13 k59_1413508_2 1177181.T9A_01051 1.28e-35 126.0 COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,1RP3M@1236|Gammaproteobacteria,1XR05@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_891617_1 1469245.JFBG01000016_gene963 2.14e-10 58.2 2EGIJ@1|root,33AAQ@2|Bacteria,1NH9B@1224|Proteobacteria,1SGKJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2909) VL23_10685 - - - - - - - - - - - DUF2909 k59_891617_2 686340.Metal_1813 1.22e-14 74.3 COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria,1XEXY@135618|Methylococcales 135618|Methylococcales S SURF1-like protein - - - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 k59_943372_1 1187851.A33M_0718 7.41e-38 146.0 COG1995@1|root,COG3395@1|root,COG1995@2|Bacteria,COG3395@2|Bacteria,1MX5W@1224|Proteobacteria,2TSKF@28211|Alphaproteobacteria,3FCZ3@34008|Rhodovulum 28211|Alphaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262,1.1.1.408,1.1.1.409 ko:K00097,ko:K22024 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_56456_1 1121935.AQXX01000106_gene542 2.34e-07 53.5 COG0835@1|root,COG0835@2|Bacteria,1RCIR@1224|Proteobacteria,1S61F@1236|Gammaproteobacteria,1XKR5@135619|Oceanospirillales 135619|Oceanospirillales NT Chemotaxis signal transduction protein pilI - - ko:K02659 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - CheW k59_56456_2 762948.HMPREF0733_10552 6.34e-15 75.5 COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,1W7R4@1268|Micrococcaceae 201174|Actinobacteria T response regulator phoP - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_56456_3 34506.g5868 1.69e-12 69.3 COG0524@1|root,COG1957@1|root,COG1972@1|root,KOG2855@2759|Eukaryota,KOG2938@2759|Eukaryota,KOG3747@2759|Eukaryota,39TNV@33154|Opisthokonta,3BMUJ@33208|Metazoa,3CX7T@33213|Bilateria,40HV5@6231|Nematoda,1M13H@119089|Chromadorea,40S74@6236|Rhabditida 33208|Metazoa F Inosine-uridine preferring nucleoside hydrolase - - - - - - - - - - - - IU_nuc_hydro k59_107528_1 391589.RGAI101_4096 2.28e-38 141.0 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TUMK@28211|Alphaproteobacteria,2P11U@2433|Roseobacter 28211|Alphaproteobacteria E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_107528_2 266779.Meso_3230 5.33e-89 263.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2TQZM@28211|Alphaproteobacteria,43H36@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_159069_1 1442599.JAAN01000041_gene3146 1.43e-17 79.0 2EIP6@1|root,33CEJ@2|Bacteria,1NJA2@1224|Proteobacteria,1SHW0@1236|Gammaproteobacteria,1X8HN@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_421366_2 1127692.HMPREF9075_02379 7.58e-77 240.0 COG0270@1|root,COG0270@2|Bacteria,4NVMZ@976|Bacteroidetes,1IEAJ@117743|Flavobacteriia,1EQWM@1016|Capnocytophaga 976|Bacteroidetes L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_683275_1 754477.Q7C_1175 2.79e-73 240.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,45ZU0@72273|Thiotrichales 72273|Thiotrichales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_1466255_1 349102.Rsph17025_1578 3.42e-48 171.0 COG0665@1|root,COG0665@2|Bacteria,1MU7M@1224|Proteobacteria,2TT69@28211|Alphaproteobacteria,1FB4E@1060|Rhodobacter 28211|Alphaproteobacteria E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_421367_1 697303.Thewi_2673 1.29e-27 112.0 COG0446@1|root,COG0446@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,42EW6@68295|Thermoanaerobacterales 186801|Clostridia C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase noxE - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,Rhodanese k59_421367_2 608538.HTH_1728 2.8e-37 142.0 COG1538@1|root,COG1538@2|Bacteria,2G3WW@200783|Aquificae 200783|Aquificae MU outer membrane efflux protein - - - - - - - - - - - - OEP k59_1048860_1 338966.Ppro_2227 0.000396 49.3 COG3850@1|root,COG5002@1|root,COG3850@2|Bacteria,COG5002@2|Bacteria,1QU7C@1224|Proteobacteria,43CFY@68525|delta/epsilon subdivisions,2WIV2@28221|Deltaproteobacteria 28221|Deltaproteobacteria T histidine kinase HAMP region domain protein - - 2.7.13.3 ko:K07642 ko02020,map02020 M00450,M00645,M00646,M00648 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_1206510_1 1206731.BAGB01000145_gene4198 1.26e-66 212.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2I1D3@201174|Actinobacteria,4G7XC@85025|Nocardiaceae 201174|Actinobacteria L Winged helix-turn helix - - - - - - - - - - - - HTH_33 k59_944009_1 1395587.P364_0120485 5.72e-63 198.0 COG0454@1|root,COG0456@2|Bacteria,1VW2R@1239|Firmicutes,4I7IK@91061|Bacilli,26WWV@186822|Paenibacillaceae 91061|Bacilli K GNAT family acetyltransferase - - - - - - - - - - - - Acetyltransf_10 k59_1258677_2 643562.Daes_1699 6.88e-16 79.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2M7U6@213115|Desulfovibrionales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K01338,ko:K04076,ko:K04770 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Lon_C k59_1414283_1 935863.AWZR01000002_gene777 1.1e-13 70.9 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1X3T4@135614|Xanthomonadales 135614|Xanthomonadales O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process dsbC - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_1309764_1 1047013.AQSP01000144_gene858 1.27e-11 69.7 COG0438@1|root,COG0438@2|Bacteria,2NQ17@2323|unclassified Bacteria 2|Bacteria M glycosyl transferase group 1 tuaC GO:0003674,GO:0003824,GO:0016740,GO:0016757 - ko:K16697 - - - - ko00000,ko01000,ko01003 - GT4 iYO844.BSU35590 Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_578685_1 550540.Fbal_1407 1.86e-15 82.8 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella mltF2 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_317872_1 1235457.C404_12430 7.64e-11 65.1 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,2VUM6@28216|Betaproteobacteria,1KFQ5@119060|Burkholderiaceae 28216|Betaproteobacteria S colicin v production cvpA - - ko:K03558 - - - - ko00000 - - - Colicin_V k59_317872_2 236097.ADG881_2972 8.86e-11 64.3 COG3147@1|root,COG3147@2|Bacteria,1N5X5@1224|Proteobacteria 1224|Proteobacteria S Protein conserved in bacteria - - - ko:K03749 - - - - ko00000 - - - SPOR k59_735399_1 765420.OSCT_2815 2.39e-61 215.0 COG0178@1|root,COG0178@2|Bacteria,2G60U@200795|Chloroflexi,3751P@32061|Chloroflexia 32061|Chloroflexia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_57304_1 439235.Dalk_5215 6.08e-37 137.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2WIQN@28221|Deltaproteobacteria,2MI44@213118|Desulfobacterales 28221|Deltaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_1623451_1 706587.Desti_0453 1.17e-55 194.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2MQV9@213462|Syntrophobacterales 28221|Deltaproteobacteria D RecF/RecN/SMC N terminal domain smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_108186_2 211165.AJLN01000116_gene3118 0.000507 43.5 COG1842@1|root,COG1842@2|Bacteria,1G0JY@1117|Cyanobacteria,1JIEF@1189|Stigonemataceae 1117|Cyanobacteria KT PspA/IM30 family - - - ko:K03969 - - - - ko00000 - - - PspA_IM30 k59_892314_1 161156.JQKW01000010_gene387 6.97e-70 232.0 COG0465@1|root,COG0465@2|Bacteria,2GHGM@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_892314_2 1304885.AUEY01000013_gene3127 4.46e-36 134.0 COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,42PNI@68525|delta/epsilon subdivisions,2WJNF@28221|Deltaproteobacteria,2MQ1R@213118|Desulfobacterales 28221|Deltaproteobacteria P Natural resistance-associated macrophage protein mntH - - ko:K03322 - - - - ko00000,ko02000 2.A.55.2.6,2.A.55.3 - - Nramp,Usp k59_1258687_1 631362.Thi970DRAFT_04215 5.38e-68 213.0 COG3751@1|root,COG3751@2|Bacteria,1RBXB@1224|Proteobacteria,1RR8W@1236|Gammaproteobacteria,1WWUG@135613|Chromatiales 135613|Chromatiales O 2OG-Fe(II) oxygenase superfamily - - - - - - - - - - - - 2OG-FeII_Oxy_3 k59_1258687_2 765911.Thivi_1188 1.12e-32 120.0 28QMK@1|root,2ZD39@2|Bacteria,1RAWM@1224|Proteobacteria,1S2FU@1236|Gammaproteobacteria,1WY0Y@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_684103_1 1097668.BYI23_B011680 1.06e-27 116.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,1K0DB@119060|Burkholderiaceae 28216|Betaproteobacteria H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k59_1153187_2 754035.Mesau_00656 1.72e-25 107.0 COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,43KK9@69277|Phyllobacteriaceae 28211|Alphaproteobacteria H 2-dehydropantoate 2-reductase panE - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_213055_1 1230343.CANP01000029_gene2285 2.06e-50 181.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1JCZZ@118969|Legionellales 118969|Legionellales V AcrB/AcrD/AcrF family mdtC - - - - - - - - - - - ACR_tran k59_1362326_1 748247.AZKH_0352 1.12e-37 137.0 COG2010@1|root,COG2010@2|Bacteria,1R48P@1224|Proteobacteria,2VPF4@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3 k59_944027_1 498211.CJA_2687 1.48e-80 251.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1FG2U@10|Cellvibrio 1236|Gammaproteobacteria F Carbamoyl-phosphate synthase small chain, CPSase domain carA GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,ic_1306.c0040 CPSase_sm_chain,GATase k59_1414301_1 1201293.AKXQ01000008_gene683 4.24e-52 184.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_1206543_1 1131553.JIBI01000046_gene1600 2.53e-81 260.0 COG2855@1|root,COG2855@2|Bacteria 2|Bacteria P membrane - - - - - - - - - - - - Cons_hypoth698 k59_159541_1 1403819.BATR01000066_gene1997 7.71e-90 278.0 COG0577@1|root,COG0577@2|Bacteria,46TM1@74201|Verrucomicrobia,2IVW0@203494|Verrucomicrobiae 203494|Verrucomicrobiae V MacB-like periplasmic core domain - - - - - - - - - - - - MacB_PCD k59_159541_2 583355.Caka_2184 3.61e-79 243.0 COG1136@1|root,COG1136@2|Bacteria 2|Bacteria V lipoprotein transporter activity - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_788629_1 644966.Tmar_1330 1.54e-74 239.0 COG3173@1|root,COG3173@2|Bacteria,1TSCJ@1239|Firmicutes 1239|Firmicutes S Aminoglycoside phosphotransferase - - - - - - - - - - - - APH k59_684129_1 1335757.SPICUR_04975 8.41e-59 199.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1WW2V@135613|Chromatiales 135613|Chromatiales M zinc metalloprotease - - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_684129_2 472759.Nhal_2460 1.99e-08 55.8 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales 135613|Chromatiales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_788634_2 1470591.BW41_02249 4.28e-22 94.0 COG1213@1|root,COG1213@2|Bacteria,1RB54@1224|Proteobacteria,2U5XC@28211|Alphaproteobacteria,2K2S2@204457|Sphingomonadales 204457|Sphingomonadales M Nucleotidyltransferase - - - - - - - - - - - - NTP_transf_3,NTP_transferase k59_526404_1 156889.Mmc1_2524 2.7e-05 47.4 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U2CU@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_526404_2 314285.KT71_11690 3.75e-21 90.5 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,1RPGK@1236|Gammaproteobacteria,1J5MH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q and related enzymes yghX - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_317909_1 1157637.KB892146_gene7212 6.02e-44 149.0 COG3576@1|root,COG3576@2|Bacteria,2GKCF@201174|Actinobacteria 201174|Actinobacteria S pyridoxamine 5-phosphate - - - - - - - - - - - - Putative_PNPOx k59_1048924_1 330214.NIDE1795 7.35e-104 318.0 COG4581@1|root,COG4581@2|Bacteria 2|Bacteria L dead DEAH box helicase helY GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K03727 - - - - ko00000,ko01000 - - - DEAD,DSHCT,Helicase_C,rRNA_proc-arch k59_788640_1 237368.SCABRO_03325 1.74e-96 293.0 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups gpgS - 2.4.1.266,2.4.1.268 ko:K13693,ko:K21349 - - - - ko00000,ko01000,ko01003 - GT81 - Glycos_transf_2 k59_1048929_1 1123504.JQKD01000006_gene1649 1.85e-43 152.0 COG0500@1|root,COG2226@2|Bacteria,1MVXG@1224|Proteobacteria,2VM9F@28216|Betaproteobacteria,4ADEU@80864|Comamonadaceae 28216|Betaproteobacteria H ubiE/COQ5 methyltransferase family - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_1048929_2 1230341.MJ3_10181 4.37e-30 111.0 COG4818@1|root,COG4818@2|Bacteria,1VBIZ@1239|Firmicutes,4HKBZ@91061|Bacilli 91061|Bacilli S membrane - - - - - - - - - - - - DUF4870 k59_1048929_3 36809.MAB_1219 3.97e-54 177.0 COG1028@1|root,COG1028@2|Bacteria,2HP88@201174|Actinobacteria,23415@1762|Mycobacteriaceae 201174|Actinobacteria IQ Dehydrogenase - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_526418_1 338963.Pcar_0087 8.55e-90 291.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,43SBD@69541|Desulfuromonadales 28221|Deltaproteobacteria L ABC transporter uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_317919_1 1120972.AUMH01000009_gene440 6.09e-12 67.4 COG0564@1|root,COG0564@2|Bacteria,1TSM6@1239|Firmicutes,4HA7M@91061|Bacilli 91061|Bacilli J Responsible for synthesis of pseudouridine from uracil rluA GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_213099_1 1379270.AUXF01000006_gene26 5.33e-12 73.6 COG0457@1|root,COG0457@2|Bacteria,1ZU0J@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_8 k59_1517678_1 105559.Nwat_2176 4.28e-219 645.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1570939_1 1229909.NSED_02345 3.99e-36 131.0 arCOG08732@1|root,arCOG08732@2157|Archaea,41SR6@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1517679_2 395492.Rleg2_3128 0.000255 46.2 COG2244@1|root,COG2244@2|Bacteria,1MUMD@1224|Proteobacteria,2TTZ8@28211|Alphaproteobacteria,4B9HJ@82115|Rhizobiaceae 28211|Alphaproteobacteria S Membrane protein involved in the export of O-antigen and teichoic acid - - - ko:K03328 - - - - ko00000 2.A.66.2 - - Polysacc_synt_3,Polysacc_synt_C k59_684181_1 247639.MGP2080_00820 5.65e-68 214.0 COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,1RRXT@1236|Gammaproteobacteria,1J4ZN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F COG1428 Deoxynucleoside kinases dgk - - - - - - - - - - - dNK k59_684181_2 929713.NIASO_06200 3.74e-05 45.4 COG0413@1|root,COG0413@2|Bacteria,4NDX4@976|Bacteroidetes,1IRN1@117747|Sphingobacteriia 976|Bacteroidetes H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_996247_1 754477.Q7C_2468 1.49e-97 303.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,45ZXC@72273|Thiotrichales 72273|Thiotrichales C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_788673_1 1121937.AUHJ01000005_gene2226 4.74e-88 268.0 COG2141@1|root,COG2141@2|Bacteria,1MWDV@1224|Proteobacteria,1SWMP@1236|Gammaproteobacteria,46975@72275|Alteromonadaceae 1224|Proteobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_735461_1 269799.Gmet_2506 1.71e-50 175.0 COG0705@1|root,COG0705@2|Bacteria,1N258@1224|Proteobacteria,42UB4@68525|delta/epsilon subdivisions,2WQJ3@28221|Deltaproteobacteria,43U5E@69541|Desulfuromonadales 28221|Deltaproteobacteria S Rhomboid family - - - - - - - - - - - - Rhomboid k59_1570950_1 701347.Entcl_2573 7.83e-15 80.5 COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,1RQ9P@1236|Gammaproteobacteria,3X3NN@547|Enterobacter 1236|Gammaproteobacteria M Glycosyl transferase family 21 - - 2.4.1.12 ko:K00694 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - Cellulose_synt,Glycos_transf_2,PilZ k59_474036_1 868595.Desca_0740 1.27e-82 257.0 COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,248WH@186801|Clostridia,266VE@186807|Peptococcaceae 186801|Clostridia U TIGRFAM ABC transporter, urea, permease protein, UrtC - - - ko:K01998,ko:K11961 ko02010,ko02024,map02010,map02024 M00237,M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4,3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_1153265_2 472759.Nhal_2276 6.7e-72 220.0 COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,1S5ZI@1236|Gammaproteobacteria,1WYD6@135613|Chromatiales 135613|Chromatiales P Belongs to the Fur family - - - ko:K09823 ko02024,map02024 - - - ko00000,ko00001,ko03000 - - - FUR k59_1206635_1 869210.Marky_1931 5.9e-51 174.0 COG0277@1|root,COG0277@2|Bacteria,1WKVA@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Berberine and berberine like - - - - - - - - - - - - BBE,FAD_binding_4 k59_944103_1 330214.NIDE3442 1.21e-45 160.0 COG3705@1|root,COG3705@2|Bacteria,3J13R@40117|Nitrospirae 40117|Nitrospirae E Histidyl-tRNA synthetase - - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_1309860_1 443152.MDG893_14710 1.59e-80 249.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,464H0@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_735994_2 396588.Tgr7_0929 2.85e-129 385.0 COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,1RP39@1236|Gammaproteobacteria,1X2QU@135613|Chromatiales 135613|Chromatiales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_892963_2 765914.ThisiDRAFT_1935 1.75e-22 95.5 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RQ04@1236|Gammaproteobacteria,1WXUZ@135613|Chromatiales 135613|Chromatiales U Part of a membrane complex involved in electron transport - - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_996868_1 314345.SPV1_03033 5.03e-61 196.0 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria 1224|Proteobacteria T OST-HTH/LOTUS domain - - - - - - - - - - - - NYN,OST-HTH k59_58118_1 436308.Nmar_0423 1.32e-22 92.0 COG0066@1|root,arCOG02230@2157|Archaea,41T1U@651137|Thaumarchaeota 651137|Thaumarchaeota E 3-isopropylmalate dehydratase, small subunit - - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_58118_2 1229909.NSED_02205 3.2e-63 199.0 COG1208@1|root,arCOG00663@2157|Archaea 2157|Archaea M PFAM Nucleotidyl transferase - - 2.6.1.37,2.7.7.13 ko:K00966,ko:K03430 ko00051,ko00440,ko00520,ko01100,ko01110,ko01120,map00051,map00440,map00520,map01100,map01110,map01120 M00114,M00361,M00362 R00885,R04152 RC00002,RC00008,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - NTP_transferase k59_370430_1 379066.GAU_2382 1.13e-79 247.0 COG1013@1|root,COG1013@2|Bacteria,1ZSWT@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_370430_2 1280953.HOC_18124 2.15e-245 693.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,43Z43@69657|Hyphomonadaceae 28211|Alphaproteobacteria C pyruvate flavodoxin ferredoxin oxidoreductase MA20_01045 - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1467722_1 1123070.KB899247_gene1531 4.83e-31 127.0 COG2010@1|root,COG2010@2|Bacteria,46U0M@74201|Verrucomicrobia,2IV63@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Protein of unknown function (DUF1549) - - - - - - - - - - - - PSCyt1,PSCyt2,PSD1 k59_1415064_2 1469245.JFBG01000011_gene845 3.06e-60 199.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales 135613|Chromatiales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_1362930_1 1121937.AUHJ01000004_gene1156 9.43e-76 235.0 COG4221@1|root,COG4221@2|Bacteria,1MVYG@1224|Proteobacteria,1S354@1236|Gammaproteobacteria,46CJC@72275|Alteromonadaceae 1236|Gammaproteobacteria S KR domain - - - - - - - - - - - - adh_short k59_1310485_1 1298593.TOL_0898 2.27e-59 194.0 COG1196@1|root,COG1196@2|Bacteria,1NGHR@1224|Proteobacteria,1RQW7@1236|Gammaproteobacteria,1XKSV@135619|Oceanospirillales 135619|Oceanospirillales D Protein of unknown function (DUF3450) - - - - - - - - - - - - DUF3450 k59_1153902_1 488538.SAR116_0056 1.4e-200 562.0 COG0596@1|root,COG0596@2|Bacteria,1MWVN@1224|Proteobacteria,2TQVB@28211|Alphaproteobacteria,4BPWP@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Epoxide hydrolase N terminus - - 3.3.2.9 ko:K01253 ko00980,ko04976,ko05204,map00980,map04976,map05204 - R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443 RC01447,RC01728,RC01764,RC02528 ko00000,ko00001,ko01000,ko01002 - - - EHN k59_1153902_2 1229172.JQFA01000002_gene4383 5.4e-47 155.0 COG1047@1|root,COG1047@2|Bacteria,1G5R4@1117|Cyanobacteria,1HBDB@1150|Oscillatoriales 1117|Cyanobacteria O PFAM FKBP-type peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - FKBP_C k59_422685_1 1123368.AUIS01000011_gene1180 1.34e-119 366.0 COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,1RRS6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF885 k59_684914_1 1120705.FG95_00665 6.7e-06 55.8 COG4206@1|root,COG4206@2|Bacteria,1R1WX@1224|Proteobacteria,2U0GK@28211|Alphaproteobacteria,2K1DC@204457|Sphingomonadales 204457|Sphingomonadales H receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1467731_1 28229.ND2E_1736 7.81e-25 101.0 COG3339@1|root,COG3339@2|Bacteria,1RAN7@1224|Proteobacteria,1S291@1236|Gammaproteobacteria,2Q6RN@267889|Colwelliaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF1232) - - - - - - - - - - - - DUF1232 k59_213690_2 266835.14026170 8.12e-21 95.5 COG3745@1|root,COG3745@2|Bacteria,1MYVE@1224|Proteobacteria,2U7QC@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Pilus assembly protein CpaB - - - ko:K02279 - - - - ko00000,ko02035,ko02044 - - - RcpC,SAF k59_1207472_1 1229909.NSED_09740 1.01e-106 314.0 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon k59_840603_1 926566.Terro_0330 8.55e-22 95.5 COG4301@1|root,COG4301@2|Bacteria,3Y2JF@57723|Acidobacteria,2JIA5@204432|Acidobacteriia 204432|Acidobacteriia S Histidine-specific methyltransferase, SAM-dependent - - - - - - - - - - - - Methyltransf_33 k59_1571556_1 296591.Bpro_2299 7.92e-97 304.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,4AA75@80864|Comamonadaceae 28216|Betaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_1571556_2 1535422.ND16A_3594 3.66e-40 135.0 COG3785@1|root,COG3785@2|Bacteria,1RHM7@1224|Proteobacteria,1T11M@1236|Gammaproteobacteria,2Q8A0@267889|Colwelliaceae 1236|Gammaproteobacteria S Hemimethylated DNA-binding protein YccV like - - - ko:K11940 - - - - ko00000,ko03036 - - - YccV-like k59_1571556_3 228410.NE2300 3.34e-142 412.0 COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,2VHZZ@28216|Betaproteobacteria,3729W@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_527009_1 113395.AXAI01000014_gene220 8.25e-46 167.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_1571560_1 67356.KL575636_gene4560 3e-09 65.1 COG0582@1|root,COG0582@2|Bacteria,2GMMI@201174|Actinobacteria 201174|Actinobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase k59_789414_1 547163.BN979_03115 3.41e-74 234.0 COG0300@1|root,COG0300@2|Bacteria,2I64P@201174|Actinobacteria,234PI@1762|Mycobacteriaceae 201174|Actinobacteria S KR domain - - - - - - - - - - - - adh_short k59_789414_2 402881.Plav_0758 3.35e-115 341.0 COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2TUT7@28211|Alphaproteobacteria,1JNXV@119043|Rhodobiaceae 28211|Alphaproteobacteria S PFAM 2-nitropropane dioxygenase NPD - - 1.13.12.16,1.3.1.9 ko:K00459,ko:K02371 ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212 M00083 R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076,RC02541,RC02759 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO k59_1259602_2 462590.A9J587_BPPYU 3.49e-55 181.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0005575,GO:0019012,GO:0019028,GO:0032991,GO:0044423,GO:0046806 - - - - - - - - - - - k59_474780_1 1121374.KB891575_gene1044 7.22e-37 139.0 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,1RXYY@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q cytochrome p450 - - - - - - - - - - - - p450 k59_1310518_2 1249627.D779_0601 7.29e-08 53.9 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1WWDA@135613|Chromatiales 135613|Chromatiales J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_58176_1 1397528.Q671_00770 2.02e-48 166.0 COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,1RSCG@1236|Gammaproteobacteria,1XP0T@135619|Oceanospirillales 135619|Oceanospirillales H Radical SAM superfamily - - 2.5.1.77 ko:K11779 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_1207509_1 1121272.KB903272_gene106 1.37e-05 47.8 COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,4DA9T@85008|Micromonosporales 201174|Actinobacteria S Glycosyltransferase like family 2 - - - ko:K07011 - - - - ko00000 - - - Glycos_transf_2 k59_944663_1 1229909.NSED_04250 2.06e-85 268.0 COG0168@1|root,COG0517@1|root,arCOG00606@2157|Archaea,arCOG04145@2157|Archaea,41SZ8@651137|Thaumarchaeota 651137|Thaumarchaeota P CBS domain - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - CBS,TrkH k59_474801_1 105559.Nwat_0059 2.95e-120 384.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_632849_1 1384054.N790_05510 3.59e-35 138.0 COG0823@1|root,COG0823@2|Bacteria,1MWYK@1224|Proteobacteria,1RXYW@1236|Gammaproteobacteria,1XD03@135614|Xanthomonadales 135614|Xanthomonadales U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 k59_579397_1 324602.Caur_0549 6.86e-73 231.0 COG2128@1|root,COG2128@2|Bacteria,2G7WP@200795|Chloroflexi,376HC@32061|Chloroflexia 32061|Chloroflexia S Protein of unknown function (DUF3179) - - - - - - - - - - - - DUF3179 k59_422730_1 459349.CLOAM1546 8.63e-11 64.7 COG0457@1|root,COG3604@1|root,COG0457@2|Bacteria,COG3604@2|Bacteria 2|Bacteria KT transcription factor binding nifA - - ko:K02584,ko:K11914 ko02020,map02020 - - - ko00000,ko00001,ko02044,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_422730_2 1318628.MARLIPOL_15924 1.93e-12 64.3 2E31J@1|root,32Y1Y@2|Bacteria,1N745@1224|Proteobacteria,1SCMM@1236|Gammaproteobacteria,46B7F@72275|Alteromonadaceae 1236|Gammaproteobacteria S MAPEG family - - - - - - - - - - - - MAPEG k59_1153953_2 6326.BUX.s00128.29 2.49e-06 46.6 COG1324@1|root,KOG3338@2759|Eukaryota,3A1S2@33154|Opisthokonta,3BQH3@33208|Metazoa,3D77M@33213|Bilateria 33208|Metazoa P copper ion binding CUTA GO:0003674,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0008104,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0019899,GO:0022607,GO:0033036,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0046872,GO:0046914,GO:0051179,GO:0051259,GO:0051260,GO:0065003,GO:0071840 - ko:K03926 - - - - ko00000 - - - CutA1 k59_1207518_1 382464.ABSI01000010_gene3668 3.43e-135 400.0 COG0843@1|root,COG0843@2|Bacteria,46S4Q@74201|Verrucomicrobia,2ITKY@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 k59_736054_1 748247.AZKH_2771 3.56e-05 45.1 COG0476@1|root,COG0607@1|root,COG1977@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,COG1977@2|Bacteria,1MW7H@1224|Proteobacteria,2VPHM@28216|Betaproteobacteria,2M00W@206389|Rhodocyclales 206389|Rhodocyclales H ThiF family - - - - - - - - - - - - Rhodanese,ThiF k59_736054_2 1095769.CAHF01000006_gene1916 1.44e-39 135.0 COG1310@1|root,COG1310@2|Bacteria 2|Bacteria S proteolysis - - - - - - - - - - - - Prok-JAB k59_736054_3 1157490.EL26_07110 9.19e-11 61.6 COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,4H9U5@91061|Bacilli,2782C@186823|Alicyclobacillaceae 91061|Bacilli M RmlD substrate binding domain galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_789455_1 1120965.AUBV01000009_gene3065 1.98e-13 69.3 COG0463@1|root,COG0463@2|Bacteria,4NSG7@976|Bacteroidetes,47XIN@768503|Cytophagia 976|Bacteroidetes M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_789455_2 1163617.SCD_n02390 5.11e-48 163.0 COG0463@1|root,COG0463@2|Bacteria,1MXC1@1224|Proteobacteria,2VPGH@28216|Betaproteobacteria 28216|Betaproteobacteria M Pfam Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_213726_2 405948.SACE_3868 7.08e-22 95.1 COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,4E30B@85010|Pseudonocardiales 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_789458_1 1384054.N790_13875 5.06e-41 154.0 COG0729@1|root,COG1752@1|root,COG0729@2|Bacteria,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,1X39X@135614|Xanthomonadales 135614|Xanthomonadales M Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,Patatin k59_108861_1 471223.GWCH70_1957 3.86e-50 167.0 COG2135@1|root,COG2135@2|Bacteria,1TRRV@1239|Firmicutes,4HDUN@91061|Bacilli,1WFK4@129337|Geobacillus 91061|Bacilli S Belongs to the SOS response-associated peptidase family yoqW - - - - - - - - - - - SRAP k59_840647_1 335543.Sfum_1184 4.96e-16 79.3 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1PFB9@1224|Proteobacteria,437WC@68525|delta/epsilon subdivisions,2X35Z@28221|Deltaproteobacteria,2MS2F@213462|Syntrophobacterales 28221|Deltaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - - k59_840647_2 1173024.KI912151_gene1909 1.32e-23 93.2 COG3791@1|root,COG3791@2|Bacteria,1G5S8@1117|Cyanobacteria,1JIPD@1189|Stigonemataceae 1117|Cyanobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_789462_1 338966.Ppro_2754 2.25e-24 102.0 COG0535@1|root,COG0535@2|Bacteria,1RG5U@1224|Proteobacteria,42RKR@68525|delta/epsilon subdivisions,2WNUX@28221|Deltaproteobacteria,43VVF@69541|Desulfuromonadales 28221|Deltaproteobacteria C Iron-sulfur cluster-binding domain - - - - - - - - - - - - Radical_SAM,SPASM k59_579419_1 382464.ABSI01000014_gene1485 1.05e-94 308.0 COG0841@1|root,COG0841@2|Bacteria,46Z6Y@74201|Verrucomicrobia,2ITZB@203494|Verrucomicrobiae 203494|Verrucomicrobiae V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_318661_1 867903.ThesuDRAFT_01213 2.26e-72 232.0 COG0114@1|root,COG0114@2|Bacteria,1UHPH@1239|Firmicutes,25F3I@186801|Clostridia,3WCCI@538999|Clostridiales incertae sedis 186801|Clostridia C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_1518153_1 1123487.KB892841_gene4286 5.29e-47 171.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KVC7@206389|Rhodocyclales 206389|Rhodocyclales T PAC sensor-containing diguanylate cyclase phosphodiesterase - - - - - - - - - - - - CBS,EAL,GGDEF,PAS,PAS_9 k59_2613_1 323261.Noc_2813 1.71e-66 215.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales 135613|Chromatiales K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_1571611_1 909663.KI867149_gene3452 5.8e-17 80.1 COG0057@1|root,COG0057@2|Bacteria,1R8ZT@1224|Proteobacteria,42PY6@68525|delta/epsilon subdivisions,2WKEI@28221|Deltaproteobacteria,2MR58@213462|Syntrophobacterales 28221|Deltaproteobacteria G Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain - - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_1571611_2 1229780.BN381_150017 1e-132 387.0 COG2070@1|root,COG2070@2|Bacteria,2GKA6@201174|Actinobacteria,3UXGG@52018|unclassified Actinobacteria (class) 201174|Actinobacteria S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - NMO k59_1518154_1 331869.BAL199_06474 4.67e-13 67.8 COG2095@1|root,COG2095@2|Bacteria 2|Bacteria U MarC family integral membrane protein marC - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_213745_2 247639.MGP2080_08139 2.93e-67 223.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1JA1T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EQ Hydantoinase/oxoprolinase N-terminal region hyuA - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_58230_1 1121413.JMKT01000017_gene426 6.31e-19 90.9 COG1615@1|root,COG1615@2|Bacteria,1MZ5A@1224|Proteobacteria,42M4M@68525|delta/epsilon subdivisions,2WIPI@28221|Deltaproteobacteria,2MEAF@213115|Desulfovibrionales 28221|Deltaproteobacteria S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 k59_996972_1 1120983.KB894571_gene2692 3.04e-77 242.0 COG2126@1|root,COG2126@2|Bacteria,1MXCS@1224|Proteobacteria,2TWZ9@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Ion channel - - - - - - - - - - - - Ion_trans_2 k59_685008_2 493475.GARC_3298 5.77e-67 220.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,465AD@72275|Alteromonadaceae 1236|Gammaproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - iECSE_1348.ECSE_3895,iJN746.PP_5056 Metalloenzyme,Phosphodiest,iPGM_N k59_1363000_1 717785.HYPMC_2658 2.38e-16 81.3 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2TR53@28211|Alphaproteobacteria,3N6GW@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_1050341_1 289376.THEYE_A0592 1.48e-92 286.0 COG1030@1|root,COG1030@2|Bacteria,3J0WF@40117|Nitrospirae 40117|Nitrospirae O NfeD-like C-terminal, partner-binding - - - ko:K07403 - - - - ko00000 - - - NfeD k59_266815_2 1528098.NOVO_04830 1.38e-15 78.6 COG5424@1|root,COG5424@2|Bacteria,1PV6D@1224|Proteobacteria,2V6N7@28211|Alphaproteobacteria,47F6F@766|Rickettsiales 766|Rickettsiales H Iron-containing redox enzyme - - 1.3.3.11 ko:K06137 - - - - ko00000,ko01000 - - - Haem_oxygenas_2 k59_1624810_1 1353529.M899_1418 4.73e-10 60.5 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MA3@68525|delta/epsilon subdivisions,2WM1D@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the DegT DnrJ EryC1 family ddhC - 1.17.1.1 ko:K12452 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - DegT_DnrJ_EryC1 k59_1624810_2 99598.Cal7507_2062 3.81e-47 163.0 COG1089@1|root,COG1089@2|Bacteria,1G0M4@1117|Cyanobacteria,1HJST@1161|Nostocales 1117|Cyanobacteria M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_371185_1 933262.AXAM01000093_gene1586 1.65e-78 242.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,42N0M@68525|delta/epsilon subdivisions,2WJ7D@28221|Deltaproteobacteria,2MHZH@213118|Desulfobacterales 28221|Deltaproteobacteria L TIGRFAM tyrosine recombinase XerD xerD - - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_266826_1 309801.trd_1640 6.01e-90 285.0 COG0443@1|root,COG0443@2|Bacteria,2G5U5@200795|Chloroflexi,27Y4Z@189775|Thermomicrobia 189775|Thermomicrobia O MreB/Mbl protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_685904_1 713586.KB900536_gene1690 1.84e-76 260.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_997747_1 533247.CRD_02079 1.2e-63 209.0 COG0520@1|root,COG0520@2|Bacteria,1G15D@1117|Cyanobacteria,1HKUK@1161|Nostocales 1117|Cyanobacteria E Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family nifS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_790391_1 339670.Bamb_4814 6.54e-16 79.3 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MURA@1224|Proteobacteria,2VJYK@28216|Betaproteobacteria,1K220@119060|Burkholderiaceae 28216|Betaproteobacteria P PFAM beta-lactamase domain protein - - - - - - - - - - - - Lactamase_B,Rhodanese k59_527707_1 65489.OBART12G15930.1 8.75e-30 120.0 COG0006@1|root,KOG2414@2759|Eukaryota,37HHB@33090|Viridiplantae,3GA57@35493|Streptophyta,3KNV5@4447|Liliopsida,3I5BX@38820|Poales 35493|Streptophyta E Aminopeptidase P, N-terminal domain - GO:0003008,GO:0003014,GO:0003094,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0030145,GO:0032501,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0051604,GO:0070006,GO:0070011,GO:0071704,GO:0097205,GO:0140096,GO:1901564 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_685910_1 1120999.JONM01000025_gene3022 4.83e-48 164.0 COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VIAV@28216|Betaproteobacteria,2KR64@206351|Neisseriales 206351|Neisseriales T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 k59_1208505_1 1211815.CBYP010000063_gene1911 1.04e-251 706.0 COG3185@1|root,COG3185@2|Bacteria,2GJNC@201174|Actinobacteria,4EU7X@85013|Frankiales 201174|Actinobacteria E Acyclic terpene utilisation family protein AtuA - - - - - - - - - - - - AtuA k59_371199_1 1232410.KI421428_gene1164 1.2e-52 175.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2WKBC@28221|Deltaproteobacteria,43SC9@69541|Desulfuromonadales 28221|Deltaproteobacteria E Amino acid kinase family argB GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_266834_1 756272.Plabr_2914 1.43e-28 118.0 COG3452@1|root,COG3614@1|root,COG3829@1|root,COG4251@1|root,COG3452@2|Bacteria,COG3614@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,2IZV4@203682|Planctomycetes 203682|Planctomycetes T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_9 k59_945396_1 573065.Astex_1924 3.02e-38 145.0 COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,2TTAX@28211|Alphaproteobacteria,2KFFQ@204458|Caulobacterales 204458|Caulobacterales E peptidase S9A prolyl oligopeptidase domain protein beta-propeller - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_1260621_1 765914.ThisiDRAFT_1759 1.19e-25 100.0 COG0702@1|root,COG0702@2|Bacteria,1QV7M@1224|Proteobacteria,1T2N4@1236|Gammaproteobacteria,1WYK0@135613|Chromatiales 135613|Chromatiales GM intermediate-associated protein 30 - - - - - - - - - - - - CIA30 k59_1572327_1 948565.AFFP02000004_gene761 1.16e-18 82.8 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,1Y7T1@135625|Pasteurellales 135625|Pasteurellales S Belongs to the UPF0234 family - - - ko:K09767 - - - - ko00000 - - - DUF520 k59_1572327_2 1333998.M2A_0323 5.74e-07 50.1 COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,2TV8S@28211|Alphaproteobacteria,4BQ7S@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length fabA - 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_527717_1 414684.RC1_2673 1.47e-09 58.5 2BZNP@1|root,30717@2|Bacteria,1REWN@1224|Proteobacteria,2U7X0@28211|Alphaproteobacteria,2JSDR@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function (DUF2889) - - - - - - - - - - - - DUF2889 k59_527717_2 292.DM42_5314 1.57e-37 134.0 COG3917@1|root,COG3917@2|Bacteria,1RJFB@1224|Proteobacteria,2VPYN@28216|Betaproteobacteria,1K3J6@119060|Burkholderiaceae 28216|Betaproteobacteria Q 2-hydroxychromene-2-carboxylate isomerase - - - - - - - - - - - - DSBA k59_423438_1 330214.NIDE1793 2.9e-39 144.0 COG4571@1|root,COG4571@2|Bacteria 2|Bacteria M Outer membrane protease ompT GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009279,GO:0016020,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0043170,GO:0044238,GO:0044425,GO:0044462,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.23.48,3.4.23.49 ko:K01355,ko:K08477,ko:K08566,ko:K13520 ko01503,ko02020,map01503,map02020 M00744 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko01504 - - - Omptin k59_59202_1 929562.Emtol_4027 3.08e-15 79.7 COG1912@1|root,COG1912@2|Bacteria,4NG9Y@976|Bacteroidetes,47JFS@768503|Cytophagia 976|Bacteroidetes S S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans k59_945403_1 1123504.JQKD01000005_gene4788 3.41e-63 204.0 28HG7@1|root,2Z7S3@2|Bacteria,1R60A@1224|Proteobacteria,2W09G@28216|Betaproteobacteria 28216|Betaproteobacteria S Mycothiol maleylpyruvate isomerase N-terminal domain - - - - - - - - - - - - MDMPI_N k59_59203_1 1177154.Y5S_00577 1.2e-17 77.0 2CCNX@1|root,32RW4@2|Bacteria,1N3P1@1224|Proteobacteria,1SAFG@1236|Gammaproteobacteria,1XMIS@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_59203_2 1282876.BAOK01000001_gene973 2.16e-07 53.1 28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,2TUAV@28211|Alphaproteobacteria,4BS8T@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1518649_1 234267.Acid_1989 0.000173 50.1 COG3118@1|root,COG3118@2|Bacteria 2|Bacteria O belongs to the thioredoxin family ybbN GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_1154737_1 156889.Mmc1_3622 1.99e-46 167.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2TQMX@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_160522_1 126957.SMAR008618-PA 5.49e-25 114.0 COG0457@1|root,KOG1124@2759|Eukaryota,38F8U@33154|Opisthokonta,3BAQE@33208|Metazoa,3CV5D@33213|Bilateria,41XV8@6656|Arthropoda 33208|Metazoa S Transmembrane and TMTC1 - - - - - - - - - - - DUF1736,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_2858_1 864051.BurJ1DRAFT_1461 6.05e-53 179.0 COG1082@1|root,COG1082@2|Bacteria,1NHXC@1224|Proteobacteria,2VRSG@28216|Betaproteobacteria 28216|Betaproteobacteria G Xylose isomerase domain protein TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_160523_1 1002340.AFCF01000031_gene4101 5.59e-22 100.0 COG2114@1|root,COG2114@2|Bacteria,1ND4Q@1224|Proteobacteria,2U51W@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Protein of unknown function (DUF2652) - - - - - - - - - - - - DUF2652,Polyketide_cyc2 k59_1102666_1 477974.Daud_1050 3.31e-45 167.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,2605R@186807|Peptococcaceae 186801|Clostridia L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_475596_2 1283300.ATXB01000001_gene1077 1e-22 95.9 COG5488@1|root,COG5488@2|Bacteria,1N9B7@1224|Proteobacteria,1SF1J@1236|Gammaproteobacteria,1XGQI@135618|Methylococcales 135618|Methylococcales S Integral membrane protein (DUF2244) - - - - - - - - - - - - DUF2244 k59_736824_2 1454007.JAUG01000093_gene164 7.17e-08 55.8 COG1595@1|root,COG1595@2|Bacteria,4NP9A@976|Bacteroidetes,1ISI4@117747|Sphingobacteriia 976|Bacteroidetes K COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_580189_1 247633.GP2143_09795 3.15e-39 148.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation - - - - - - - - - - - - ABC_membrane,ABC_tran k59_1311351_1 189753.AXAS01000151_gene8503 2.85e-59 197.0 COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2TVFI@28211|Alphaproteobacteria,3JU9X@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L DNA invertase Pin - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom k59_633863_1 748449.Halha_1439 8.25e-11 67.4 COG0644@1|root,COG0644@2|Bacteria,1TRRU@1239|Firmicutes,24BZ3@186801|Clostridia 186801|Clostridia C TIGRFAM geranylgeranyl reductase - - - - - - - - - - - - FAD_binding_3 k59_790443_3 1487953.JMKF01000019_gene2273 6.16e-47 163.0 COG4990@1|root,COG4990@2|Bacteria,1G79T@1117|Cyanobacteria,1HBY3@1150|Oscillatoriales 1117|Cyanobacteria S Papain-like cysteine protease AvrRpt2 - - - - - - - - - - - - Peptidase_C39_2 k59_945430_1 1283287.KB822575_gene314 5.4e-17 84.0 COG0767@1|root,COG1127@1|root,COG0767@2|Bacteria,COG1127@2|Bacteria,2GXR8@201174|Actinobacteria,4DU72@85009|Propionibacteriales 201174|Actinobacteria Q Permease MlaE yrbE4A - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_945430_2 1304885.AUEY01000012_gene1816 1.16e-11 67.8 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MG3@68525|delta/epsilon subdivisions,2WKC7@28221|Deltaproteobacteria,2MJDD@213118|Desulfobacterales 28221|Deltaproteobacteria Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE,STAS_2 k59_109633_1 349124.Hhal_1743 2.02e-31 124.0 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,1S28B@1236|Gammaproteobacteria 1236|Gammaproteobacteria L nucleotidyltransferase DNA polymerase involved in DNA repair imuB - - ko:K14161 - - - - ko00000,ko03400 - - - IMS k59_319474_1 469383.Cwoe_2969 1.48e-14 72.0 COG0328@1|root,COG0328@2|Bacteria,2GK53@201174|Actinobacteria,4CQP6@84995|Rubrobacteria 84995|Rubrobacteria L RNase H - - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_790455_1 1234595.C725_2088 8.12e-91 281.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria,4BRUT@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G Domain of unknown function (DUF3459) - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - Alpha-amylase,DUF3459 k59_790459_1 883126.HMPREF9710_03138 7.53e-13 63.9 COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,2VXVA@28216|Betaproteobacteria 28216|Betaproteobacteria H ThiS family thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_790459_2 765914.ThisiDRAFT_2162 1.64e-146 418.0 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,1RMPD@1236|Gammaproteobacteria,1WW65@135613|Chromatiales 135613|Chromatiales H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG k59_1624892_1 1121272.KB903249_gene2022 1.62e-07 60.1 COG1834@1|root,COG1834@2|Bacteria,2I99J@201174|Actinobacteria,4DERT@85008|Micromonosporales 201174|Actinobacteria E amidinotransferase - - 2.1.4.1 ko:K00613 ko00260,ko00330,ko01100,map00260,map00330,map01100 M00047 R00565,R01989 RC00024,RC02749 ko00000,ko00001,ko00002,ko01000 - - - - k59_109655_1 257313.BP2864 1.1e-32 126.0 COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,2VJXC@28216|Betaproteobacteria,3T8TE@506|Alcaligenaceae 28216|Betaproteobacteria C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_423498_1 96561.Dole_2118 1.83e-63 216.0 COG0318@1|root,COG0318@2|Bacteria,1NUXN@1224|Proteobacteria 1224|Proteobacteria IQ AMP-binding enzyme - - - - - - - - - - - - AMP-binding k59_371258_1 1266925.JHVX01000001_gene2629 1.88e-154 464.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,37225@32003|Nitrosomonadales 28216|Betaproteobacteria IQ AMP-dependent synthetase - - - - - - - - - - - - AMP-binding,Acyltransferase,PP-binding k59_1363752_1 314278.NB231_11184 2.42e-89 283.0 COG0517@1|root,COG0538@1|root,COG0517@2|Bacteria,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1WVYY@135613|Chromatiales 135613|Chromatiales C TIGRFAM isocitrate dehydrogenase, NADP-dependent - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - CBS,Iso_dh k59_160556_1 1232437.KL662050_gene5314 2.09e-55 194.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,42NWZ@68525|delta/epsilon subdivisions,2WJU7@28221|Deltaproteobacteria,2MJ2C@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_893875_1 1357272.AVEO02000210_gene3290 2.03e-53 189.0 COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1Z4WY@136849|Pseudomonas syringae group 1236|Gammaproteobacteria T Sensory box GGDEF domain EAL ykoW - - - - - - - - - - - 4HB_MCP_1,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_790486_1 913325.N799_04375 9.59e-20 92.4 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1X3WM@135614|Xanthomonadales 135614|Xanthomonadales J Methylates ribosomal protein L11 prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_580231_1 519989.ECTPHS_04044 8.5e-31 109.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,1WYVD@135613|Chromatiales 135613|Chromatiales J Belongs to the bacterial ribosomal protein bL27 family rpmA - - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_580231_2 188626.HMPREF0321_1549 3.78e-16 75.9 COG0261@1|root,COG0261@2|Bacteria,2IQ9A@201174|Actinobacteria,1ZW3H@145357|Dermacoccaceae 201174|Actinobacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_1468852_2 713587.THITH_07010 8.39e-27 111.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1WXWN@135613|Chromatiales 135613|Chromatiales I PFAM 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1260728_2 1131269.AQVV01000078_gene256 1.07e-57 183.0 COG0377@1|root,COG0377@2|Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient ndhK - 1.6.5.3 ko:K00331,ko:K05582 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iJN678.ndhK Oxidored_q6 k59_686022_1 671143.DAMO_0160 9.53e-150 438.0 28J7E@1|root,2Z92U@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4105) - - - - - - - - - - - - DUF4105 k59_997840_1 1121033.AUCF01000003_gene3156 3.37e-100 305.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,2JPGU@204441|Rhodospirillales 204441|Rhodospirillales H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.96 ko:K16871 ko00250,ko00650,ko01100,ko01120,map00250,map00650,map01100,map01120 M00027 R10178 RC00008,RC00062 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_3 k59_1572403_2 1541065.JRFE01000024_gene1084 1.95e-128 376.0 COG0714@1|root,COG0714@2|Bacteria,1G0WS@1117|Cyanobacteria,3VNGC@52604|Pleurocapsales 1117|Cyanobacteria S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1572403_3 243233.MCA2267 1.31e-20 87.0 COG0778@1|root,COG0778@2|Bacteria,1RA6E@1224|Proteobacteria,1S460@1236|Gammaproteobacteria,1XF58@135618|Methylococcales 135618|Methylococcales C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_686029_1 584708.Apau_1431 5.21e-52 175.0 COG2255@1|root,COG2255@2|Bacteria,3T9QM@508458|Synergistetes 508458|Synergistetes L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_1572991_2 1049564.TevJSym_ax00380 2.37e-145 426.0 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1J4IM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302,ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_3999 CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_1155476_1 404380.Gbem_3913 5.02e-27 112.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WK06@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1155476_2 404589.Anae109_4150 1.78e-53 193.0 COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,42M49@68525|delta/epsilon subdivisions,2WJ5G@28221|Deltaproteobacteria,2YU0Y@29|Myxococcales 28221|Deltaproteobacteria J Selenocysteine-specific translation elongation factor selB - - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 k59_1469716_1 1121926.AXWO01000003_gene785 8.66e-27 114.0 COG1966@1|root,COG1966@2|Bacteria,2GIYX@201174|Actinobacteria,4EZD0@85014|Glycomycetales 201174|Actinobacteria T 5TM C-terminal transporter carbon starvation CstA cstA - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM k59_894570_1 391615.ABSJ01000026_gene110 4.27e-32 124.0 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1J6A4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria PT COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - Rhodanese,cNMP_binding k59_1051250_1 396595.TK90_0985 3.79e-61 209.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WXY0@135613|Chromatiales 135613|Chromatiales P Sulfate transporter antisigma-factor antagonist STAS - - - - - - - - - - - - STAS,Sulfate_transp k59_580870_1 316067.Geob_3370 3.2e-71 231.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43UCF@69541|Desulfuromonadales 28221|Deltaproteobacteria T response regulator pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_580870_2 67257.JODR01000008_gene3478 4.08e-07 52.4 COG0642@1|root,COG2205@2|Bacteria,2GNUQ@201174|Actinobacteria 201174|Actinobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k59_1519173_1 1267005.KB911255_gene2792 9.28e-107 324.0 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TUMK@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0665 Glycine D-amino acid oxidases (deaminating) - - - - - - - - - - - - DAO k59_894572_1 90675.XP_010444454.1 1.75e-48 180.0 COG0661@1|root,KOG1235@2759|Eukaryota,37PWH@33090|Viridiplantae,3G9ZN@35493|Streptophyta,3HVVT@3699|Brassicales 35493|Streptophyta S ABC1 family - GO:0000302,GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006643,GO:0006950,GO:0006979,GO:0007275,GO:0007568,GO:0007623,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009314,GO:0009416,GO:0009507,GO:0009526,GO:0009536,GO:0009605,GO:0009628,GO:0009636,GO:0009642,GO:0009644,GO:0009941,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010150,GO:0031667,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0033554,GO:0034599,GO:0042221,GO:0042493,GO:0042542,GO:0042592,GO:0042594,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046467,GO:0046677,GO:0046686,GO:0048366,GO:0048367,GO:0048511,GO:0048583,GO:0048731,GO:0048827,GO:0048856,GO:0048878,GO:0050789,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0065007,GO:0065008,GO:0070887,GO:0071704,GO:0080134,GO:0090693,GO:0098771,GO:0099402,GO:1901031,GO:1901576,GO:1901700,GO:1902882,GO:1990641 - - - - - - - - - - ABC1 k59_1261601_1 1321781.HMPREF1985_00190 1.64e-39 147.0 COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,4H3K8@909932|Negativicutes 909932|Negativicutes S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_842144_1 1280953.HOC_15457 1.6e-08 62.4 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2TWE1@28211|Alphaproteobacteria,43XFJ@69657|Hyphomonadaceae 28211|Alphaproteobacteria E COG0501 Zn-dependent protease with chaperone function - - - - - - - - - - - - Peptidase_M48 k59_1469736_1 1038869.AXAN01000121_gene498 3.3e-22 97.8 COG3436@1|root,COG3436@2|Bacteria,1MYAC@1224|Proteobacteria,2WI9J@28216|Betaproteobacteria 28216|Betaproteobacteria L IS66 C-terminal element - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C k59_528518_2 204669.Acid345_1175 5.66e-37 136.0 COG0182@1|root,COG0182@2|Bacteria,3Y2TR@57723|Acidobacteria,2JHZX@204432|Acidobacteriia 204432|Acidobacteriia J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B k59_946087_2 1123279.ATUS01000001_gene2540 1.32e-30 116.0 COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1J6HX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S integral membrane protein yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_1312085_2 1220535.IMCC14465_09120 0.000625 41.6 COG1028@1|root,COG1028@2|Bacteria,1R77Y@1224|Proteobacteria,2U3IQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ short-chain dehydrogenase - - - - - - - - - - - - adh_short_C2 k59_580889_2 713587.THITH_02930 1.07e-45 153.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,1WYG6@135613|Chromatiales 135613|Chromatiales M Belongs to the ompA family - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_215209_1 258594.RPA1945 5.83e-06 47.8 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TTM5@28211|Alphaproteobacteria,3JR50@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate frc - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_215209_2 1123401.JHYQ01000001_gene1721 2.31e-19 89.7 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,45ZUP@72273|Thiotrichales 72273|Thiotrichales E Aminotransferase aspC2 - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_737568_1 1121287.AUMU01000010_gene1875 3.61e-90 279.0 COG0451@1|root,COG0451@2|Bacteria,4NEKA@976|Bacteroidetes,1HY26@117743|Flavobacteriia,3ZPTE@59732|Chryseobacterium 976|Bacteroidetes M epimerase - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_634834_1 404589.Anae109_1104 2.07e-51 187.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,2YU71@29|Myxococcales 28221|Deltaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1261622_1 671143.DAMO_0961 8.86e-60 208.0 COG1538@1|root,COG1538@2|Bacteria,2NPI8@2323|unclassified Bacteria 2|Bacteria MU Outer membrane efflux protein cebC - - - - - - - - - - - OEP k59_1261622_2 1161401.ASJA01000002_gene2626 8.35e-12 66.6 COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,2TTGG@28211|Alphaproteobacteria,43WVF@69657|Hyphomonadaceae 28211|Alphaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cusB - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - CusF_Ec,HlyD_D23,HlyD_D4 k59_320306_1 243233.MCA0982 1.38e-10 62.4 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1XFEK@135618|Methylococcales 135618|Methylococcales O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_320306_2 316067.Geob_0929 6.36e-35 127.0 COG2823@1|root,COG2823@2|Bacteria,1RFX5@1224|Proteobacteria,42UUG@68525|delta/epsilon subdivisions,2WQ1N@28221|Deltaproteobacteria,43U92@69541|Desulfuromonadales 28221|Deltaproteobacteria S BON domain - - - - - - - - - - - - BON k59_161108_1 713586.KB900536_gene926 6.06e-152 451.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales 135613|Chromatiales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1573035_1 1549858.MC45_00055 4.72e-85 275.0 COG0323@1|root,COG0323@2|Bacteria,1R57G@1224|Proteobacteria,2UEXM@28211|Alphaproteobacteria,2KC76@204457|Sphingomonadales 204457|Sphingomonadales L DNA mismatch repair - - - - - - - - - - - - - k59_215230_1 1205680.CAKO01000002_gene2354 1.29e-14 73.6 COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,2TRCB@28211|Alphaproteobacteria,2JPJQ@204441|Rhodospirillales 204441|Rhodospirillales E Pyridoxal-phosphate dependent enzyme - - - - - - - - - - - - PALP k59_215230_2 105559.Nwat_1970 2.61e-28 108.0 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1S5PP@1236|Gammaproteobacteria,1WYN6@135613|Chromatiales 135613|Chromatiales K SMART cyclic nucleotide-binding - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1628128_1 887062.HGR_12372 0.000537 42.4 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,4AD3D@80864|Comamonadaceae 28216|Betaproteobacteria I Enoyl-CoA hydratase carnithine racemase - - - - - - - - - - - - ECH_1 k59_1628128_2 237368.SCABRO_00846 5.06e-39 134.0 2CCSR@1|root,32RWC@2|Bacteria,2J1M5@203682|Planctomycetes 203682|Planctomycetes S 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_374464_1 1328313.DS2_03655 2.8e-18 84.7 COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,1RPS3@1236|Gammaproteobacteria,4656V@72275|Alteromonadaceae 1236|Gammaproteobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_794687_1 1247649.D560_0945 2.65e-60 207.0 COG2159@1|root,COG2159@2|Bacteria,1R7D7@1224|Proteobacteria,2VNK3@28216|Betaproteobacteria 28216|Betaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_583120_1 1217708.F887_02143 1.98e-07 51.6 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1RS4F@1236|Gammaproteobacteria,3NK0A@468|Moraxellaceae 1236|Gammaproteobacteria S Predicted membrane protein (DUF2238) yjdF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K08984 - - - - ko00000 - - - DUF2238 k59_794688_1 1122194.AUHU01000021_gene3469 5.35e-20 86.7 COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,1S3PA@1236|Gammaproteobacteria,467U5@72275|Alteromonadaceae 1236|Gammaproteobacteria U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE k59_794688_2 748247.AZKH_4011 8.83e-54 173.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,2VKUA@28216|Betaproteobacteria,2KUIE@206389|Rhodocyclales 206389|Rhodocyclales K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_794692_1 1459636.NTE_02229 4.01e-41 149.0 COG1239@1|root,arCOG00438@2157|Archaea 2157|Archaea H magnesium chelatase - - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - - AAA_5 k59_1000491_1 1040989.AWZU01000008_gene3647 2.92e-97 309.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_1157637_1 314278.NB231_11719 2.35e-73 235.0 COG1215@1|root,COG1215@2|Bacteria,1MW1E@1224|Proteobacteria,1RZY2@1236|Gammaproteobacteria,1X091@135613|Chromatiales 135613|Chromatiales M Glycosyl transferase family 21 - - - - - - - - - - - - Glyco_tranf_2_3 k59_1264666_1 1313172.YM304_04770 3.25e-38 142.0 COG3178@1|root,COG3178@2|Bacteria,2GN8T@201174|Actinobacteria 201174|Actinobacteria S Ecdysteroid kinase - - - - - - - - - - - - EcKinase k59_689611_1 713586.KB900536_gene139 6.32e-64 202.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1WX9S@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_4259_1 713586.KB900536_gene2241 9.08e-157 447.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1WW00@135613|Chromatiales 135613|Chromatiales H Belongs to the ALAD family - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_4259_2 227377.CBU_0015 2.42e-07 51.6 COG1392@1|root,COG1392@2|Bacteria,1MXY9@1224|Proteobacteria,1RQHT@1236|Gammaproteobacteria,1JDM6@118969|Legionellales 118969|Legionellales P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_637933_2 369723.Strop_0517 3.09e-79 246.0 2EES9@1|root,338JX@2|Bacteria,2H5MY@201174|Actinobacteria 201174|Actinobacteria L RNase_H superfamily - - - - - - - - - - - - RNase_H_2 k59_478966_1 82654.Pse7367_1116 1.78e-09 59.7 COG2912@1|root,COG2912@2|Bacteria,1G11S@1117|Cyanobacteria,1H8P0@1150|Oscillatoriales 1117|Cyanobacteria S Transglutaminase-like superfamily - - - - - - - - - - - - TPR_9,Transglut_core2 k59_478966_2 935837.JAEK01000004_gene4795 3.42e-31 120.0 COG1972@1|root,COG1972@2|Bacteria,1TRSK@1239|Firmicutes,4HA8N@91061|Bacilli,1ZAW2@1386|Bacillus 91061|Bacilli F Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family yutK GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015858,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505,GO:1901642 - ko:K03317 - - - - ko00000 2.A.41 - iYO844.BSU32180 Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_794716_1 880073.Calab_1939 2.38e-25 110.0 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,2NP45@2323|unclassified Bacteria 2|Bacteria M Patatin-like phospholipase plpD - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin k59_63382_1 266265.Bxe_C1164 2.14e-32 124.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,1JZMS@119060|Burkholderiaceae 28216|Betaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_63382_2 1380394.JADL01000003_gene5066 1.18e-20 92.8 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria,2JPBE@204441|Rhodospirillales 204441|Rhodospirillales I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_948372_1 247634.GPB2148_813 3.9e-78 250.0 COG1231@1|root,COG1231@2|Bacteria,1QXX6@1224|Proteobacteria,1T3IZ@1236|Gammaproteobacteria,1J5KT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - 1.5.99.6 ko:K00316 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R01914,R01915 RC00053,RC00225 ko00000,ko00001,ko01000 - - - NAD_binding_8 k59_1000509_2 1122165.AUHS01000015_gene728 2.38e-05 46.2 COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,1S9N2@1236|Gammaproteobacteria,1JDV5@118969|Legionellales 118969|Legionellales C Cytochrome B561 yceJ - - ko:K12262 - - - - ko00000 - - - Ni_hydr_CYTB k59_583134_2 1157490.EL26_18435 1.03e-59 187.0 COG0346@1|root,COG0346@2|Bacteria,1V7D7@1239|Firmicutes,4HIGP@91061|Bacilli 91061|Bacilli E glyoxalase - - - - - - - - - - - - Glyoxalase,NUDIX k59_583134_5 460265.Mnod_0228 1.71e-17 83.6 COG1028@1|root,COG1028@2|Bacteria,1PEWK@1224|Proteobacteria,2TV4E@28211|Alphaproteobacteria,1JU3C@119045|Methylobacteriaceae 28211|Alphaproteobacteria IQ PFAM short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1628165_1 314225.ELI_08560 1.2e-05 48.9 COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,2U1PN@28211|Alphaproteobacteria,2KCZM@204457|Sphingomonadales 204457|Sphingomonadales Q dithiol-disulfide isomerase involved in polyketide biosynthesis - - - - - - - - - - - - DSBA k59_1628165_2 292459.STH3041 1.94e-26 100.0 COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,24HD9@186801|Clostridia 186801|Clostridia J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_1520728_1 754476.Q7A_1050 2.25e-10 66.6 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,45ZVU@72273|Thiotrichales 72273|Thiotrichales M PFAM AsmA family - - - ko:K07289 - - - - ko00000 - - - AsmA k59_637947_1 1038859.AXAU01000028_gene30 1.7e-68 233.0 COG0348@1|root,COG3889@1|root,COG0348@2|Bacteria,COG3889@2|Bacteria,1R9JQ@1224|Proteobacteria,2U3WR@28211|Alphaproteobacteria,3K36U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C domain, Protein - - - - - - - - - - - - - k59_794736_1 1167006.UWK_02384 3.43e-36 142.0 COG0531@1|root,COG0531@2|Bacteria,1R4IZ@1224|Proteobacteria,42MTQ@68525|delta/epsilon subdivisions,2WK39@28221|Deltaproteobacteria,2MIIG@213118|Desulfobacterales 28221|Deltaproteobacteria E Amino acid permease - - - - - - - - - - - - AA_permease,SLC12 k59_1212580_1 1232410.KI421425_gene1550 1.27e-31 124.0 COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,42Z0Q@68525|delta/epsilon subdivisions,2WU0G@28221|Deltaproteobacteria,43T6R@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_796002_1 1265313.HRUBRA_00560 4.33e-91 284.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_584080_1 1163617.SCD_n01736 5.5e-111 333.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria 28216|Betaproteobacteria C Catalyzes the reversible hydration of fumarate to (S)- malate fumA - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_375520_1 572477.Alvin_3101 9.2e-58 202.0 COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WVXV@135613|Chromatiales 135613|Chromatiales CP Na H antiporter - - - ko:K05559 - - - - ko00000,ko02000 2.A.63.1 - - DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N k59_1054516_1 1147145.K7P832_9CAUD 6.68e-16 84.7 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0019012,GO:0019028,GO:0042802,GO:0044423 - - - - - - - - - - - k59_531829_1 1254432.SCE1572_06160 1.24e-10 68.2 COG1716@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2208@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity rsbU - 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315,ko:K16922 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko01002,ko03021 - - - CHASE2,FHA,GAF,GAF_2,HATPase_c_2,SpoIIE,Yop-YscD_cpl k59_1367824_1 755178.Cyan10605_0489 3.61e-69 239.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1G0XM@1117|Cyanobacteria 1117|Cyanobacteria E Glutamate synthase gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.7.1 ko:K00284 ko00630,ko00910,ko01120,map00630,map00910,map01120 - R00021,R10086 RC00006,RC00010 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_949322_1 1265505.ATUG01000001_gene4129 2.71e-34 134.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,42NB4@68525|delta/epsilon subdivisions,2WK9E@28221|Deltaproteobacteria,2MHUB@213118|Desulfobacterales 28221|Deltaproteobacteria D G-rich domain on putative tyrosine kinase wzc2 - - ko:K16554 ko05111,map05111 - - - ko00000,ko00001,ko02000 8.A.3.1 - - AAA_31,CbiA,GNVR,ParA,Wzz k59_740772_1 1126627.BAWE01000004_gene3241 2.02e-34 137.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1 k59_584094_1 479431.Namu_1348 5.61e-83 268.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4ES72@85013|Frankiales 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_218638_1 675817.VDA_002947 1.71e-10 64.3 COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1XSH3@135623|Vibrionales 135623|Vibrionales MU general secretion pathway protein exeA - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1,T2SSB k59_1001531_1 519989.ECTPHS_01999 3.54e-59 201.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1WWS1@135613|Chromatiales 135613|Chromatiales H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_1054533_1 304371.MCP_2535 4.36e-36 138.0 COG2006@1|root,arCOG02447@2157|Archaea 2157|Archaea S 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - - - - - - - - - - DUF362 k59_113459_1 1123248.KB893386_gene1935 7.32e-17 81.6 2C852@1|root,32YB2@2|Bacteria,4NM63@976|Bacteroidetes,1IX0W@117747|Sphingobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4136) - - - - - - - - - - - - DUF4136 k59_113459_2 596151.DesfrDRAFT_0903 2.53e-29 114.0 2AGU9@1|root,3172M@2|Bacteria,1PYAW@1224|Proteobacteria,437WS@68525|delta/epsilon subdivisions,2X36E@28221|Deltaproteobacteria,2MDM4@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1420298_1 768671.ThimaDRAFT_0602 8.95e-256 741.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW08@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_375551_1 945713.IALB_2612 1.18e-70 229.0 COG0423@1|root,COG0423@2|Bacteria 2|Bacteria J glycyl-tRNA aminoacylation glyQS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iSB619.SA_RS07880 HGTP_anticodon,tRNA-synt_2b k59_1521357_2 172088.AUGA01000022_gene569 3.76e-31 120.0 COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,2U0CV@28211|Alphaproteobacteria,3JUP6@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.14.13.235 ko:K22027 - - - - ko00000,ko01000 - - - Acyl-CoA_dh_2,Acyl-CoA_dh_N k59_113465_1 643562.Daes_1741 3.62e-15 75.5 COG0517@1|root,COG0517@2|Bacteria,1QUKQ@1224|Proteobacteria,42TPD@68525|delta/epsilon subdivisions,2WQQ5@28221|Deltaproteobacteria,2MC2I@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM CBS domain containing protein - - - - - - - - - - - - CBS k59_690594_1 1123274.KB899407_gene260 5.74e-25 105.0 COG0618@1|root,COG0618@2|Bacteria,2J7S6@203691|Spirochaetes 203691|Spirochaetes S DHH superfamily protein, subfamily 1 - - - - - - - - - - - - DHH,DHHA1 k59_64628_1 472759.Nhal_0475 7.03e-58 201.0 COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,1WX80@135613|Chromatiales 135613|Chromatiales M PFAM LppC - - - ko:K07121 - - - - ko00000 - - - LppC k59_64628_2 314287.GB2207_07058 3.36e-22 92.0 COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,1SC8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the UPF0102 family yraN - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_1213611_1 1313172.YM304_26210 6.92e-60 206.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria,4CMW5@84992|Acidimicrobiia 201174|Actinobacteria CJ CoA binding domain acdA1 - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_375557_1 1123355.JHYO01000030_gene358 7.84e-60 211.0 COG0247@1|root,COG0277@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG0479@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria 28211|Alphaproteobacteria C FAD linked oxidase domain protein - - - ko:K18930 - - - - ko00000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8 k59_1054549_1 471853.Bcav_0627 1.49e-11 72.0 COG1404@1|root,COG2373@1|root,COG3386@1|root,COG1404@2|Bacteria,COG2373@2|Bacteria,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity bpr GO:0005575,GO:0005576 - ko:K13276,ko:K13735,ko:K14274 ko00040,ko05100,map00040,map05100 - R02427 RC00713 ko00000,ko00001,ko01000,ko01002,ko03110 - - - CarbopepD_reg_2,CarboxypepD_reg,Inhibitor_I9,Malectin,PKD,Peptidase_M6,Peptidase_S8,SGL k59_1265894_1 120017.I2FZ20 1.66e-19 87.8 COG1028@1|root,KOG0725@2759|Eukaryota,38H5G@33154|Opisthokonta,3NWE0@4751|Fungi,3V039@5204|Basidiomycota,3N0ZV@452284|Ustilaginomycotina 4751|Fungi Q Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_1265894_2 264462.Bd0765 3.09e-29 109.0 COG2259@1|root,COG2259@2|Bacteria,1NCQT@1224|Proteobacteria,42WUM@68525|delta/epsilon subdivisions,2WT9R@28221|Deltaproteobacteria 28221|Deltaproteobacteria S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX k59_1213613_1 583345.Mmol_0299 3.97e-25 104.0 COG2165@1|root,COG2165@2|Bacteria,1REMT@1224|Proteobacteria,2VR8U@28216|Betaproteobacteria,2KMRF@206350|Nitrosomonadales 206350|Nitrosomonadales NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl k59_427628_1 330214.NIDE3604 7.57e-87 264.0 COG0435@1|root,COG0435@2|Bacteria 2|Bacteria O Glutathione S-transferase yqjG GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7,2.5.1.18 ko:K00799,ko:K07393 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - iECW_1372.ECW_m3373,iWFL_1372.ECW_m3373 GST_C_2,GST_N_2 k59_271024_1 158500.BV97_00343 1.12e-30 125.0 COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2JZUI@204457|Sphingomonadales 204457|Sphingomonadales P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1213618_1 1163617.SCD_n00281 9.61e-34 132.0 2A8Z1@1|root,30Y2U@2|Bacteria,1PJYG@1224|Proteobacteria,2VJ83@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_323767_1 1190606.AJYG01000074_gene171 4.51e-40 143.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RMTS@1236|Gammaproteobacteria,1XSM6@135623|Vibrionales 135623|Vibrionales P Belongs to the ABC transporter superfamily - - 3.6.3.30 ko:K02010,ko:K02052 ko02010,ko02024,map02010,map02024 M00190,M00193 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10,3.A.1.11 - - ABC_tran,TOBE_2 k59_323767_2 1211115.ALIQ01000189_gene864 4.27e-141 416.0 COG1178@1|root,COG1178@2|Bacteria,1R0MN@1224|Proteobacteria,2VFDY@28211|Alphaproteobacteria 28211|Alphaproteobacteria P binding-protein-dependent transport systems inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_845518_1 694431.DESACE_06005 1.04e-65 205.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,42MEH@68525|delta/epsilon subdivisions,2WMSC@28221|Deltaproteobacteria,2M6Q8@213113|Desulfurellales 28221|Deltaproteobacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_427638_1 1168065.DOK_19180 2.49e-21 99.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1J5I7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0405 Gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1054560_2 1454004.AW11_01238 5.65e-07 52.4 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,1KQXA@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1106895_1 472759.Nhal_3410 3.62e-52 179.0 28I4Y@1|root,2Z88D@2|Bacteria,1R95V@1224|Proteobacteria,1RRZA@1236|Gammaproteobacteria,1X010@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_639197_1 765910.MARPU_02230 3.2e-69 217.0 COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,1RQ0M@1236|Gammaproteobacteria,1WX61@135613|Chromatiales 135613|Chromatiales S PKHD-type hydroxylase - - - ko:K07336 - - - - ko00000,ko01000 - - - 2OG-FeII_Oxy_3 k59_1367878_1 70448.A0A096PBR2 5.32e-37 140.0 COG0169@1|root,KOG0692@2759|Eukaryota,37S9P@33090|Viridiplantae,34H3R@3041|Chlorophyta 3041|Chlorophyta E Belongs to the EPSP synthase family - - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_1213630_2 338966.Ppro_0400 4.43e-29 115.0 28PW7@1|root,32EDN@2|Bacteria,1N0AP@1224|Proteobacteria,42UF5@68525|delta/epsilon subdivisions,2WQ2P@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function (DUF3313) - - - - - - - - - - - - DUF3313 k59_1420348_1 1112274.KI911560_gene423 0.000552 40.8 COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2VT0P@28216|Betaproteobacteria,2KMWX@206350|Nitrosomonadales 206350|Nitrosomonadales I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_1420348_2 472759.Nhal_2439 7.1e-52 171.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1WXFG@135613|Chromatiales 135613|Chromatiales H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ - 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_639206_1 1279019.ARQK01000050_gene1285 2.37e-97 306.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales 135613|Chromatiales O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1583709_1 757424.Hsero_2736 2.35e-123 362.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,2VJ7A@28216|Betaproteobacteria,472N6@75682|Oxalobacteraceae 28216|Betaproteobacteria M UDP binding domain wecC - - ko:K02474 ko00520,map00520 - R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_748003_1 1206744.BAGL01000126_gene6174 6.19e-50 171.0 COG2103@1|root,COG2103@2|Bacteria,2GN0K@201174|Actinobacteria,4G08N@85025|Nocardiaceae 201174|Actinobacteria S Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate murQ - 4.2.1.126 ko:K07106 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - - BcrAD_BadFG,SIS,SIS_2 k59_278603_1 998674.ATTE01000001_gene1532 1.41e-28 118.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,461RX@72273|Thiotrichales 72273|Thiotrichales P Cation transporter/ATPase, N-terminus - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_122300_1 1049564.TevJSym_an00610 2.08e-78 252.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1J4DW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_331056_1 948106.AWZT01000079_gene4291 5.34e-208 622.0 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,1JZT2@119060|Burkholderiaceae 28216|Betaproteobacteria T adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - AAA_16,BTAD,Guanylate_cyc,Pkinase,SAM_1 k59_225921_1 402881.Plav_1646 1.78e-89 273.0 COG2141@1|root,COG2141@2|Bacteria,1PFU1@1224|Proteobacteria,2VA1B@28211|Alphaproteobacteria,1JQ6W@119043|Rhodobiaceae 28211|Alphaproteobacteria C Luciferase-like monooxygenase - - 1.14.13.107 ko:K14733 ko00903,map00903 - R06398,R09385,R09389,R09393 RC01506 ko00000,ko00001,ko01000 - - - Bac_luciferase k59_1584454_2 207559.Dde_3005 2.38e-84 258.0 COG2126@1|root,COG2126@2|Bacteria,1MXCS@1224|Proteobacteria,42NVQ@68525|delta/epsilon subdivisions,2WJFT@28221|Deltaproteobacteria,2MDPP@213115|Desulfovibrionales 28221|Deltaproteobacteria J Ion transport protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans k59_806800_2 1121413.JMKT01000011_gene2427 6.15e-24 98.2 COG0517@1|root,COG0517@2|Bacteria,1N0EB@1224|Proteobacteria,42W96@68525|delta/epsilon subdivisions,2WP5S@28221|Deltaproteobacteria,2MC10@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM CBS domain containing protein - - - ko:K07168 - - - - ko00000 - - - CBS k59_436099_1 1121033.AUCF01000005_gene5228 4.11e-07 50.8 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,2UPET@28211|Alphaproteobacteria,2JWPR@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde ferredoxin oxidoreductase, N-terminal domain - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_436099_3 1469245.JFBG01000007_gene674 0.000193 43.5 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,1X2DA@135613|Chromatiales 135613|Chromatiales S Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_806804_1 59538.XP_005974149.1 4.92e-27 110.0 COG0458@1|root,KOG0370@2759|Eukaryota,38CAC@33154|Opisthokonta,3B9FF@33208|Metazoa,3CS9A@33213|Bilateria,4804V@7711|Chordata,490QX@7742|Vertebrata,3J7SX@40674|Mammalia 33208|Metazoa F aspartate binding Cad - 2.1.3.2,3.5.2.3,6.3.5.5 ko:K11540 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R01397,R01993,R10948,R10949 RC00002,RC00010,RC00043,RC00064,RC00632,RC02750,RC02798,RC02850,RC03314 ko00000,ko00001,ko00002,ko01000,ko01002 - - - Amidohydro_1,CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,GATase,MGS,OTCace,OTCace_N k59_806804_2 322710.Avin_38860 1.11e-34 130.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0019897,GO:0019898,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 iE2348C_1286.E2348C_0187,iEcolC_1368.EcolC_3478 LpxB k59_592213_1 378806.STAUR_4691 5.52e-58 202.0 COG2518@1|root,COG2518@2|Bacteria,1QX9V@1224|Proteobacteria,42Z9X@68525|delta/epsilon subdivisions,2WUEX@28221|Deltaproteobacteria,2YX7N@29|Myxococcales 28221|Deltaproteobacteria O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - - - - - - - - - - - - k59_123247_1 1463853.JOHW01000006_gene4402 2.85e-97 293.0 COG0183@1|root,COG0183@2|Bacteria,2GKFR@201174|Actinobacteria 201174|Actinobacteria I lipid-transfer protein ltp2 - - - - - - - - - - - Thiolase_N k59_1062966_1 1415779.JOMH01000001_gene1470 3.76e-78 259.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1X3VS@135614|Xanthomonadales 135614|Xanthomonadales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_279340_1 335543.Sfum_3923 1.59e-54 188.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2MRI6@213462|Syntrophobacterales 28221|Deltaproteobacteria MU PFAM Outer membrane efflux protein - - - - - - - - - - - - OEP k59_806808_1 1002672.SAR11G3_00186 9.3e-71 225.0 COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,2V91I@28211|Alphaproteobacteria,4BSUW@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_906052_1 502025.Hoch_4465 2.74e-110 329.0 COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,432XE@68525|delta/epsilon subdivisions,2WYHS@28221|Deltaproteobacteria,2YU0E@29|Myxococcales 28221|Deltaproteobacteria S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - - k59_906052_2 215803.DB30_7934 1.68e-35 122.0 COG1977@1|root,COG1977@2|Bacteria,1N4M4@1224|Proteobacteria,43BB7@68525|delta/epsilon subdivisions,2X6QD@28221|Deltaproteobacteria,2Z3C9@29|Myxococcales 28221|Deltaproteobacteria H ThiS family - - - - - - - - - - - - ThiS k59_906052_3 580332.Slit_1671 3.36e-122 369.0 COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,44V1J@713636|Nitrosomonadales 28216|Betaproteobacteria C Oxidoreductase FAD-binding domain protein ascD - 1.17.1.1 ko:K00523,ko:K18248 ko00520,ko00627,ko01120,map00520,map00627,map01120 M00637 R00823,R00825,R03391,R03392 RC00192,RC00230 br01602,ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_649701_1 502025.Hoch_2284 1.08e-22 107.0 COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,43AH9@68525|delta/epsilon subdivisions,2X5XB@28221|Deltaproteobacteria,2Z37F@29|Myxococcales 28221|Deltaproteobacteria P Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Sulfatase k59_279344_1 644282.Deba_0263 5.26e-82 270.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_698677_1 247633.GP2143_05715 3.77e-38 143.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,1SB7T@1236|Gammaproteobacteria,1J963@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445,Fer2 k59_748775_1 314285.KT71_02042 4.14e-15 74.7 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1J8E3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Delta-aminolevulinic acid dehydratase hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_748775_2 330214.NIDE2742 1.13e-56 178.0 COG2905@1|root,COG2905@2|Bacteria 2|Bacteria T signal-transduction protein containing cAMP-binding and CBS domains opuCA - 2.7.7.7 ko:K02342,ko:K05847,ko:K07182 ko00230,ko00240,ko01100,ko02010,ko03030,ko03430,ko03440,map00230,map00240,map01100,map02010,map03030,map03430,map03440 M00209,M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko02000,ko03032,ko03400 3.A.1.12 - - CBS,DUF294,DUF294_C,cNMP_binding k59_279348_1 34506.g6160 3.74e-56 197.0 COG0079@1|root,COG0131@1|root,COG0139@1|root,KOG0633@2759|Eukaryota,KOG3143@2759|Eukaryota,KOG4311@2759|Eukaryota 2759|Eukaryota E phosphoribosyl-ATP diphosphatase activity HIS4 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0004400,GO:0004635,GO:0004636,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0010038,GO:0010045,GO:0016053,GO:0016462,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016769,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,2.6.1.9,3.5.4.19,3.6.1.31,4.2.1.19,4.99.1.1,4.99.1.9,5.3.1.16 ko:K00817,ko:K01693,ko:K01772,ko:K01814,ko:K11755,ko:K14152 ko00340,ko00350,ko00360,ko00400,ko00401,ko00860,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01130,map01230 M00026,M00121 R00310,R00694,R00734,R01158,R01163,R03012,R03243,R03457,R04035,R04037,R04640,R11329 RC00002,RC00006,RC00099,RC00242,RC00463,RC00888,RC00932,RC00945,RC01012,RC01055 ko00000,ko00001,ko00002,ko01000,ko01007 - - iMM904.YIL116W,iND750.YIL116W Aminotran_1_2,Histidinol_dh,PRA-CH,PRA-PH k59_436123_1 981085.XP_010108074.1 1.84e-10 67.8 COG1404@1|root,2QPQR@2759|Eukaryota,37HQV@33090|Viridiplantae,3GC98@35493|Streptophyta 35493|Streptophyta O subtilisin-like protease - - - - - - - - - - - - Inhibitor_I9,PA,Peptidase_S8 k59_436124_1 1030157.AFMP01000004_gene2062 1.33e-07 53.5 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2TR5Z@28211|Alphaproteobacteria,2K0C6@204457|Sphingomonadales 204457|Sphingomonadales S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_436124_2 1122218.KB893653_gene909 1.1e-14 73.6 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2TSS5@28211|Alphaproteobacteria,1JSGI@119045|Methylobacteriaceae 28211|Alphaproteobacteria D TIGRFAM maf protein maf - - ko:K06287 - - - - ko00000 - - - Maf k59_385543_1 868864.Dester_1517 1.36e-47 167.0 COG0165@1|root,COG0165@2|Bacteria,2G3PT@200783|Aquificae 200783|Aquificae E argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_806826_2 167555.NATL1_20431 6.74e-15 77.8 28II3@1|root,2Z8J9@2|Bacteria,1G1W0@1117|Cyanobacteria,1MM8K@1212|Prochloraceae 1117|Cyanobacteria F Catalyzes the two-electron reduction of biliverdin IX- alpha at the C15 methine bridge pebA - 1.3.7.2 ko:K05369 ko00860,ko01110,map00860,map01110 - R05818 RC01474 ko00000,ko00001,ko01000 - - - Fe_bilin_red k59_226628_1 1049564.TevJSym_ba00120 1.68e-56 189.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1J565@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M zinc metalloprotease rseP GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_226628_2 1500894.JQNN01000001_gene1635 1.42e-52 178.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2VHJY@28216|Betaproteobacteria,472C7@75682|Oxalobacteraceae 28216|Betaproteobacteria I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_1637825_1 573413.Spirs_0830 6.36e-72 229.0 COG0059@1|root,COG0059@2|Bacteria,2J60P@203691|Spirochaetes 203691|Spirochaetes H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_331810_1 1057002.KB905370_gene3019 1.37e-24 107.0 COG1409@1|root,COG2304@1|root,COG2931@1|root,COG3204@1|root,COG1409@2|Bacteria,COG2304@2|Bacteria,COG2931@2|Bacteria,COG3204@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - 3.4.24.40 ko:K01406,ko:K07004 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - An_peroxidase,Cadherin,Calx-beta,Exo_endo_phos,HemolysinCabind,Metallophos,Peptidase_M10_C k59_8090_1 1234595.C725_0518 3.04e-09 58.2 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2TR8S@28211|Alphaproteobacteria,4BP88@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_8090_2 338963.Pcar_0733 4.66e-51 171.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,42MAG@68525|delta/epsilon subdivisions,2WM94@28221|Deltaproteobacteria,43S5I@69541|Desulfuromonadales 28221|Deltaproteobacteria E Belongs to the TrpC family trpC - 4.1.1.48,5.3.1.24 ko:K01609,ko:K13498 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508,R03509 RC00944,RC00945 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2494 IGPS k59_592239_2 436308.Nmar_1740 1.02e-65 202.0 COG0652@1|root,arCOG04767@2157|Archaea,41T32@651137|Thaumarchaeota 651137|Thaumarchaeota O peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_698693_1 1212548.B381_12246 1.93e-48 169.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1YZWM@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria T signal transduction protein with a C-terminal ATPase domain algZ - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase k59_1584483_1 472759.Nhal_3081 3.23e-77 258.0 COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1X042@135613|Chromatiales 135613|Chromatiales Q Phosphate acyltransferases - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C,Acyltransferase,PP-binding k59_957336_1 926560.KE387023_gene1195 3.26e-109 343.0 COG1132@1|root,COG1132@2|Bacteria,1WM45@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_806845_1 1469245.JFBG01000014_gene2025 1.39e-134 389.0 COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,1S9CF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_806845_2 1397666.RS24_01448 6.92e-30 115.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,4BPP4@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_1114927_2 795359.TOPB45_0214 1.36e-34 130.0 COG1109@1|root,COG1109@2|Bacteria,2GHQ7@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_279380_1 247633.GP2143_13456 2.07e-73 230.0 COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,1J514@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_8096_1 1286170.RORB6_14815 4.84e-17 76.3 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - ko:K03925 - - - - ko00000 - - - MraZ k59_1375679_1 491952.Mar181_0481 3.2e-34 127.0 2DN9Q@1|root,32WAD@2|Bacteria,1MZDM@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1164973_1 608538.HTH_0605 1.29e-32 126.0 29M2U@1|root,3080B@2|Bacteria,2G5C8@200783|Aquificae 200783|Aquificae S Domain of unknown function (DUF4382) - - - - - - - - - - - - DUF4382 k59_1484496_1 1123377.AUIV01000021_gene2548 2.72e-11 62.4 COG3040@1|root,COG3040@2|Bacteria,1RIKA@1224|Proteobacteria,1T0AA@1236|Gammaproteobacteria,1X6SY@135614|Xanthomonadales 135614|Xanthomonadales M Lipocalin-like domain blc4 - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_1484496_2 575540.Isop_2757 2.46e-23 95.5 COG4276@1|root,COG4276@2|Bacteria,2J0FI@203682|Planctomycetes 203682|Planctomycetes S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc k59_748809_1 396588.Tgr7_0063 5.49e-160 469.0 COG2391@1|root,COG2391@2|Bacteria,1PF9B@1224|Proteobacteria,1SH3M@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_748809_2 1123371.ATXH01000004_gene1750 4.3e-08 52.4 COG0425@1|root,COG0425@2|Bacteria,2GIKM@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria O Sulfurtransferase TusA - - - - - - - - - - - - TusA k59_1430801_1 485916.Dtox_0326 7.69e-68 214.0 COG0705@1|root,COG0705@2|Bacteria,1TQXT@1239|Firmicutes,247PT@186801|Clostridia 186801|Clostridia S PFAM Rhomboid family GlpG - - - - - - - - - - - Rhomboid k59_1276729_1 393305.YE1134 1.99e-15 80.5 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,41G6U@629|Yersinia 1236|Gammaproteobacteria L Yersinia enterocolitica transposase for insertion sequence element IS1328 SWALL TRA8_YEREN (SWALL Q56897) (334 aa) fasta scores E() - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_1584502_1 330214.NIDE4026 1.05e-35 123.0 COG0316@1|root,COG0316@2|Bacteria,3J17Y@40117|Nitrospirae 40117|Nitrospirae S Iron-sulphur cluster biosynthesis - - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_1584502_2 330214.NIDE4025 4.5e-78 233.0 COG0822@1|root,COG0822@2|Bacteria,3J123@40117|Nitrospirae 40117|Nitrospirae C A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters - - - ko:K04488 - - - - ko00000 - - - NifU_N k59_592277_1 1131266.ARWQ01000008_gene338 7.49e-53 171.0 COG0838@1|root,arCOG01557@2157|Archaea,41SMI@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 3 - - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_539734_1 1095747.HMPREF1049_1834 3.39e-20 94.4 COG5410@1|root,COG5410@2|Bacteria,378AG@32066|Fusobacteria 32066|Fusobacteria S TIGRFAM Phage - - - - - - - - - - - - - k59_226663_1 1089553.Tph_c08220 1.18e-133 402.0 COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42ERP@68295|Thermoanaerobacterales 186801|Clostridia C Aldehyde ferredoxin oxidoreductase aor - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS09915 AFOR_C,AFOR_N k59_123329_1 1205680.CAKO01000028_gene4643 1.02e-14 71.6 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2UA46@28211|Alphaproteobacteria,2JSUT@204441|Rhodospirillales 204441|Rhodospirillales U Biopolymer transport protein tolR - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_123329_2 398767.Glov_3473 6.57e-31 116.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria 28221|Deltaproteobacteria U MotA TolQ ExbB proton channel aglX - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_226664_1 1370125.AUWT01000029_gene533 1.74e-28 109.0 COG0748@1|root,COG0748@2|Bacteria,2IIRE@201174|Actinobacteria,239MD@1762|Mycobacteriaceae 201174|Actinobacteria P F420H(2)-dependent quinone reductase ddn GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0030312,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070967,GO:0071944,GO:0097159,GO:0097367,GO:1901363 - - - - - - - - - - F420H2_quin_red k59_957357_1 1469245.JFBG01000053_gene2096 5.71e-72 234.0 COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,1RY6X@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Malonyl-CoA decarboxylase - - 4.1.1.9 ko:K01578 ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152 - R00233 RC00040 ko00000,ko00001,ko01000 - - - MCD,MCD_N k59_853667_1 96561.Dole_0728 8.38e-68 220.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria,2MHM9@213118|Desulfobacterales 28221|Deltaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_1584514_1 1279017.AQYJ01000026_gene57 2.25e-116 374.0 COG1360@1|root,COG2885@1|root,COG1360@2|Bacteria,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,1T4AK@1236|Gammaproteobacteria,46ACU@72275|Alteromonadaceae 1236|Gammaproteobacteria M OmpA family - - - - - - - - - - - - DUF11,OmpA k59_86745_1 871585.BDGL_001978 2.06e-89 274.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,3NKE8@468|Moraxellaceae 1236|Gammaproteobacteria E DegT/DnrJ/EryC1/StrS aminotransferase family aspC - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_179016_2 484770.UFO1_3340 7.15e-13 66.6 COG3124@1|root,COG3124@2|Bacteria,1V38F@1239|Firmicutes 1239|Firmicutes S Acyl carrier protein phosphodiesterase - - - - - - - - - - - - ACP_PD k59_1496338_1 472759.Nhal_0327 1.88e-137 409.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1WWBU@135613|Chromatiales 135613|Chromatiales G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) - - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_1593305_2 445686.E3SLN4_9CAUD 7.74e-20 81.3 4QAPD@10239|Viruses,4R013@35237|dsDNA viruses no RNA stage,4QR1V@28883|Caudovirales,4QK6E@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1383739_1 570967.JMLV01000009_gene1011 6.66e-103 316.0 COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,2JQ6J@204441|Rhodospirillales 204441|Rhodospirillales E COG4166 ABC-type oligopeptide transport system, periplasmic component - - - ko:K13893 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 k59_1123784_1 330214.NIDE0192 6.78e-54 179.0 COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae 2|Bacteria S Evidence 4 Homologs of previously reported genes of - - 1.14.99.50 ko:K18912 ko00340,map00340 - R11013 RC03323,RC03324 ko00000,ko00001,ko01000 - - - FGE-sulfatase,Pkinase k59_393831_1 1444770.AF72_00170 1.74e-06 49.3 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1X3DW@135614|Xanthomonadales 135614|Xanthomonadales J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_393831_2 1121468.AUBR01000030_gene1250 6.09e-22 98.2 COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,25CC4@186801|Clostridia,42IAE@68295|Thermoanaerobacterales 186801|Clostridia E Amino-transferase class IV ilvE2 - 2.6.1.42,4.1.3.38 ko:K00826,ko:K02619 ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R05553,R10991 RC00006,RC00036,RC01843,RC02148 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_548229_1 445688.E3SNU2_9CAUD 3.75e-32 129.0 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4QPWY@28883|Caudovirales,4QHVQ@10662|Myoviridae 10662|Myoviridae S nucleotide binding - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016032,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019058,GO:0019079,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0039686,GO:0039693,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044403,GO:0044419,GO:0046483,GO:0051704,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_1496375_1 1562701.BBOF01000067_gene2093 1.27e-111 335.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2VI2T@28216|Betaproteobacteria,1K1FI@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_661837_1 391589.RGAI101_1145 4.96e-55 185.0 COG1812@1|root,COG1812@2|Bacteria,1QPB9@1224|Proteobacteria,2U1WE@28211|Alphaproteobacteria 28211|Alphaproteobacteria E S-adenosylmethionine synthetase (AdoMet synthetase) - - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_Synthase k59_1328401_1 290398.Csal_1715 6.65e-80 254.0 COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,1RPY4@1236|Gammaproteobacteria,1XJV2@135619|Oceanospirillales 135619|Oceanospirillales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1071852_1 330214.NIDE3548 8.27e-54 180.0 COG0104@1|root,COG0104@2|Bacteria,3J0FV@40117|Nitrospirae 40117|Nitrospirae F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_818975_1 765913.ThidrDRAFT_3071 6.8e-10 60.8 COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,1RNMJ@1236|Gammaproteobacteria,1X0R3@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_11 k59_818975_2 983917.RGE_20320 8.69e-14 79.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VHHZ@28216|Betaproteobacteria,1KJMR@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family dmsA - 1.8.5.3 ko:K07306 ko00920,map00920 - R09501 RC02555 ko00000,ko00001,ko01000,ko02000 5.A.3.3 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_818981_1 402777.KB235903_gene443 2.06e-23 105.0 COG0745@1|root,COG3852@1|root,COG5001@1|root,COG0745@2|Bacteria,COG3852@2|Bacteria,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria,1HI87@1150|Oscillatoriales 1117|Cyanobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - CBS,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1232912_2 444860.E3SJ31_9CAUD 3.5e-77 236.0 4QB2Z@10239|Viruses,4QWQN@35237|dsDNA viruses no RNA stage,4QPYN@28883|Caudovirales,4QHWJ@10662|Myoviridae 10662|Myoviridae S gp45 sliding clamp, C terminal - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_601185_1 570952.ATVH01000017_gene1745 1.69e-54 181.0 COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,2TR1Y@28211|Alphaproteobacteria,2JPAS@204441|Rhodospirillales 204441|Rhodospirillales P transport system, permease component - - - ko:K13895 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - BPD_transp_1,OppC_N k59_601185_2 1122135.KB893134_gene3648 3.32e-21 90.9 COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,2TQJD@28211|Alphaproteobacteria 28211|Alphaproteobacteria P transport system, permease component yejB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0022857,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944 - ko:K13894 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - BPD_transp_1 k59_86796_1 234267.Acid_7524 3.25e-39 147.0 COG0612@1|root,COG0612@2|Bacteria,3Y3XF@57723|Acidobacteria 57723|Acidobacteria S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_1593337_2 402881.Plav_2961 5.84e-69 233.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,1JNHC@119043|Rhodobiaceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain coxL - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_757565_1 444860.E3SIS3_9CAUD 2.68e-19 79.3 4QBB9@10239|Viruses,4QZA6@35237|dsDNA viruses no RNA stage,4QQPK@28883|Caudovirales,4QIHX@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_757565_2 41431.PCC8801_4526 3.43e-18 84.7 2CCNY@1|root,2Z8CK@2|Bacteria,1G299@1117|Cyanobacteria,3KG9U@43988|Cyanothece 1117|Cyanobacteria H Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins cpeT - - ko:K05383 ko00196,ko01100,map00196,map01100 - - - ko00000,ko00001,ko00194 - - - CpeT k59_1593344_1 330214.NIDE2040 5.44e-122 366.0 COG0147@1|root,COG0147@2|Bacteria,3J0FG@40117|Nitrospirae 40117|Nitrospirae EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_446518_1 909663.KI867150_gene1008 9.69e-51 181.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MREW@213462|Syntrophobacterales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-3 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1288938_1 1476876.JOJO01000019_gene415 7.37e-17 83.6 COG4632@1|root,COG4632@2|Bacteria,2GNTM@201174|Actinobacteria 201174|Actinobacteria G Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase - - - - - - - - - - - - NAGPA,SPOR k59_707379_2 411463.EUBVEN_00338 2.44e-16 84.3 COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,1TT1J@1239|Firmicutes,24BC2@186801|Clostridia,25VKY@186806|Eubacteriaceae 186801|Clostridia N ABC-type uncharacterized transport system - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3,ABC_transp_aux k59_661892_2 999419.HMPREF1077_00307 1.2e-05 47.4 COG0489@1|root,COG0489@2|Bacteria,4NF5I@976|Bacteroidetes,2FKYK@200643|Bacteroidia,22WYQ@171551|Porphyromonadaceae 976|Bacteroidetes D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_1232934_1 330214.NIDE2582 6.91e-93 300.0 COG0587@1|root,COG0587@2|Bacteria,3J0FE@40117|Nitrospirae 40117|Nitrospirae L DNA-directed DNA polymerase - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1496431_1 1229909.NSED_05525 1.86e-78 241.0 COG1708@1|root,arCOG01201@2157|Archaea 2157|Archaea S nucleotidyltransferase activity - - - ko:K07076 - - - - ko00000 - - - NTP_transf_2 k59_340705_1 1229909.NSED_08170 3.54e-138 392.0 arCOG08638@1|root,arCOG08638@2157|Archaea,41T08@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_340705_2 1229909.NSED_08175 9.31e-36 126.0 arCOG08639@1|root,arCOG08639@2157|Archaea,41SP8@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1593349_1 330214.NIDE0004 4.36e-221 631.0 COG0188@1|root,COG0188@2|Bacteria,3J0EH@40117|Nitrospirae 40117|Nitrospirae L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_707387_1 204669.Acid345_3223 4.65e-85 265.0 COG1249@1|root,COG1249@2|Bacteria,3Y3ZK@57723|Acidobacteria,2JIMX@204432|Acidobacteriia 204432|Acidobacteriia C Pyridine nucleotide-disulphide oxidoreductase, dimerisation - - 1.6.1.1 ko:K00322 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_1649707_1 762376.AXYL_05427 5.07e-12 62.4 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,2VU95@28216|Betaproteobacteria,3T94K@506|Alcaligenaceae 28216|Betaproteobacteria S Sulphur oxidation protein SoxZ soxZ - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_1649707_2 207954.MED92_13498 3.39e-34 126.0 COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,1RS6A@1236|Gammaproteobacteria,1XJ4D@135619|Oceanospirillales 135619|Oceanospirillales C C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the intermediary formation of conspicuous sulfur globules inside of the cells - - - - - - - - - - - - - k59_1288961_1 744980.TRICHSKD4_5336 1.17e-17 81.6 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_862625_1 639282.DEFDS_1384 5.44e-27 110.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1 k59_1383830_2 634177.GLX_30620 6.1e-20 91.7 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2U4DT@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_1328462_1 261292.Nit79A3_3001 7.75e-76 244.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,372ME@32003|Nitrosomonadales 28216|Betaproteobacteria I AMP-dependent synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_1172125_1 522306.CAP2UW1_0173 2.9e-45 160.0 COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,2WF2J@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_32,Mu-transpos_C,rve k59_1533989_2 1380390.JIAT01000010_gene4575 0.000289 43.9 COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4CSGP@84995|Rubrobacteria 84995|Rubrobacteria Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_340748_1 936455.KI421499_gene6262 6.93e-31 116.0 COG0500@1|root,COG0500@2|Bacteria,1REJ2@1224|Proteobacteria,2U7T5@28211|Alphaproteobacteria,3JV3K@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Nodulation protein S (NodS) - - - - - - - - - - - - Methyltransf_25 k59_708394_1 1218084.BBJK01000038_gene3597 2.05e-28 116.0 COG4913@1|root,COG4913@2|Bacteria,1QUDU@1224|Proteobacteria,2WHAY@28216|Betaproteobacteria,1KIJX@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF3300) - - - - - - - - - - - - DUF3300 k59_342022_1 1121405.dsmv_1597 1.11e-102 306.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,42M3V@68525|delta/epsilon subdivisions,2WJJ4@28221|Deltaproteobacteria,2MHT5@213118|Desulfobacterales 28221|Deltaproteobacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_1019755_1 870187.Thini_3146 2.67e-51 176.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,4602E@72273|Thiotrichales 72273|Thiotrichales M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_820421_1 670252.C8CLI4_9CAUD 1.04e-18 86.3 4QD9Y@10239|Viruses,4QUXQ@35237|dsDNA viruses no RNA stage,4QTPE@28883|Caudovirales,4QNY4@10744|Podoviridae 10744|Podoviridae S Terminase-like family - - - - - - - - - - - - - k59_967120_1 243233.MCA0087 2.25e-38 148.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1XDKW@135618|Methylococcales 135618|Methylococcales NU Neisseria PilC beta-propeller domain - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_663366_1 1123053.AUDG01000057_gene3264 4.9e-20 88.2 COG2173@1|root,COG2173@2|Bacteria,1RENK@1224|Proteobacteria,1S3SJ@1236|Gammaproteobacteria,1WY7H@135613|Chromatiales 135613|Chromatiales M Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide ddpX - 3.4.13.22 ko:K08641 ko01502,ko02020,map01502,map02020 M00651 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 - - - Peptidase_M15 k59_394786_1 247634.GPB2148_2920 2.3e-45 160.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,1J4SN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_758543_1 472759.Nhal_3787 3.56e-126 367.0 COG0697@1|root,COG0697@2|Bacteria,1MVHN@1224|Proteobacteria,1RM9P@1236|Gammaproteobacteria,1X0WS@135613|Chromatiales 135613|Chromatiales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_967122_1 203122.Sde_0311 7.5e-34 123.0 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,1S60F@1236|Gammaproteobacteria,4674J@72275|Alteromonadaceae 1236|Gammaproteobacteria S aspartyl protease orf - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_967122_2 1123256.KB907926_gene663 0.000844 41.6 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,1X36W@135614|Xanthomonadales 135614|Xanthomonadales H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_1594244_1 583345.Mmol_0152 5.68e-30 121.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS_3,PAS_9 k59_134950_1 268746.Q58MM3_BPPRM 1.65e-166 483.0 4QBAK@10239|Viruses,4QY34@35237|dsDNA viruses no RNA stage,4QQBQ@28883|Caudovirales,4QIQI@10662|Myoviridae 10662|Myoviridae S Bacteriophage T4-like capsid assembly protein (Gp20) - GO:0005575,GO:0019012 - - - - - - - - - - - k59_289863_2 1121875.KB907553_gene20 4.1e-50 172.0 COG5361@1|root,COG5361@2|Bacteria,4NKSK@976|Bacteroidetes,1IARY@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_1290365_1 1385520.N802_17265 1.37e-14 75.9 COG0454@1|root,COG0456@2|Bacteria,2HXVX@201174|Actinobacteria,4FI08@85021|Intrasporangiaceae 201174|Actinobacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_179951_1 279714.FuraDRAFT_2524 1.68e-93 310.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2VI8X@28216|Betaproteobacteria 28216|Betaproteobacteria L DEAD DEAH box helicase lhr - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_1125348_1 357804.Ping_1892 3.87e-06 53.1 COG3675@1|root,COG3675@2|Bacteria,1ND8U@1224|Proteobacteria,1SCPC@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Lipase (class 3) - - - - - - - - - - - - Lipase_3 k59_1534874_1 1229909.NSED_02325 1.25e-71 218.0 COG0197@1|root,arCOG04113@2157|Archaea,41SKN@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein - - - ko:K02866 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_1045841_1 1380391.JIAS01000006_gene2517 3.42e-75 251.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2JQPR@204441|Rhodospirillales 204441|Rhodospirillales EQ Hydantoinase/oxoprolinase N-terminal region - - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_1098111_1 1283283.ATXA01000027_gene161 1.53e-41 152.0 COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria 201174|Actinobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_1463728_1 472759.Nhal_0735 6.7e-07 50.1 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1WXDV@135613|Chromatiales 135613|Chromatiales K response regulator receiver - - - ko:K13041 ko02020,map02020 M00514 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_1463728_2 1415778.JQMM01000001_gene1173 9.72e-19 82.0 COG1734@1|root,COG1734@2|Bacteria,1N8K6@1224|Proteobacteria,1SCNZ@1236|Gammaproteobacteria,1JAUG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Prokaryotic dksA/traR C4-type zinc finger - - - - - - - - - - - - zf-dskA_traR k59_628239_1 1173028.ANKO01000023_gene4403 1.56e-57 197.0 COG2358@1|root,COG2358@2|Bacteria,1G2YN@1117|Cyanobacteria,1H96P@1150|Oscillatoriales 1117|Cyanobacteria S TRAP transporter solute receptor, TAXI family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_1254897_1 870187.Thini_0311 4.17e-81 247.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,46099@72273|Thiotrichales 72273|Thiotrichales C Succinate dehydrogenase fumarate reductase sdhB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_17 k59_1254897_2 3712.Bo9g021560.1 0.000409 39.7 COG1053@1|root,KOG2403@2759|Eukaryota,37JZR@33090|Viridiplantae,3G82J@35493|Streptophyta,3HPER@3699|Brassicales 35493|Streptophyta C Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) SDH1-1 GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005749,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006119,GO:0006121,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016627,GO:0016999,GO:0017076,GO:0017144,GO:0019637,GO:0019693,GO:0019752,GO:0019866,GO:0022900,GO:0022904,GO:0030312,GO:0030554,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0035639,GO:0036094,GO:0042773,GO:0042775,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045257,GO:0045273,GO:0045281,GO:0045283,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046914,GO:0050897,GO:0055086,GO:0055114,GO:0070469,GO:0071704,GO:0071944,GO:0072350,GO:0072521,GO:0097159,GO:0097367,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902494,GO:1990204 1.3.5.1 ko:K00234 ko00020,ko00190,ko01100,ko01110,ko01120,ko01130,ko01200,ko04714,ko04932,ko05010,ko05012,ko05016,map00020,map00190,map01100,map01110,map01120,map01130,map01200,map04714,map04932,map05010,map05012,map05016 M00009,M00011,M00148 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_262326_1 1125863.JAFN01000001_gene1447 9.55e-24 102.0 COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,43C4K@68525|delta/epsilon subdivisions,2X7F1@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Domains HisKA, HATPase_c - - - - - - - - - - - - HATPase_c,HisKA k59_1254898_1 58123.JOFJ01000003_gene2073 2.15e-28 110.0 COG4221@1|root,COG4221@2|Bacteria,2I8VU@201174|Actinobacteria,4ENKB@85012|Streptosporangiales 201174|Actinobacteria S KR domain - - - - - - - - - - - - adh_short k59_1254898_2 101510.RHA1_ro04669 4.25e-15 76.3 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4FW9P@85025|Nocardiaceae 201174|Actinobacteria Q Cytochrome P450 cyp123A3 GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616,GO:1902652 - - - - - - - - - - p450 k59_941290_1 479434.Sthe_3441 1.58e-53 177.0 COG1922@1|root,COG1922@2|Bacteria,2G6PT@200795|Chloroflexi 200795|Chloroflexi M Glycosyl transferase WecB/TagA/CpsF family - - 2.4.1.187 ko:K05946 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01003 - GT26 - Glyco_tran_WecB k59_941290_2 1203556.HMPREF1478_01471 0.000228 43.9 COG0451@1|root,COG0451@2|Bacteria,2IBI2@201174|Actinobacteria,4D515@85005|Actinomycetales 201174|Actinobacteria GM NAD dependent epimerase dehydratase family protein - - 1.1.1.339 ko:K19180 ko00523,ko01130,map00523,map01130 - R10190 RC00182 ko00000,ko00001,ko01000 - - - Epimerase k59_105432_1 876044.IMCC3088_132 1.64e-34 133.0 2DBBP@1|root,2Z88Z@2|Bacteria,1R3B4@1224|Proteobacteria,1S25X@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_680430_1 1191299.AJYX01000096_gene1958 7.05e-17 80.9 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1XUBX@135623|Vibrionales 135623|Vibrionales S of the RND superfamily VP1286 - - ko:K07003 - - - - ko00000 - - - MMPL k59_1150193_1 543526.Htur_1351 7.21e-23 102.0 COG0616@1|root,arCOG01311@2157|Archaea,2XTG8@28890|Euryarchaeota,23SQY@183963|Halobacteria 183963|Halobacteria O signal peptide peptidase SppA, 36K type sppA1 - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_262336_1 76869.PputGB1_4510 1.21e-47 163.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1YWD8@136845|Pseudomonas putida group 1236|Gammaproteobacteria F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_575683_1 1211579.PP4_53570 4.24e-54 177.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1YW4H@136845|Pseudomonas putida group 1236|Gammaproteobacteria F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2813,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193 Guanylate_kin k59_628258_1 1266925.JHVX01000012_gene1723 6.98e-40 139.0 COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,2VJX3@28216|Betaproteobacteria,3720E@32003|Nitrosomonadales 28216|Betaproteobacteria O Ribosomal RNA adenine dimethylase pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_471033_1 693746.OBV_21060 5.05e-16 82.0 COG2358@1|root,COG2358@2|Bacteria,1TPXW@1239|Firmicutes,2489U@186801|Clostridia,2N6UH@216572|Oscillospiraceae 186801|Clostridia S NMT1-like family bcsP - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_575691_1 381666.H16_A3615 3.9e-73 238.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,1K01W@119060|Burkholderiaceae 28216|Betaproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_1620448_1 697282.Mettu_1547 5.89e-116 347.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1XEHZ@135618|Methylococcales 135618|Methylococcales C FAD linked oxidases, C-terminal domain - - 1.1.5.12 ko:K03777 ko00620,ko01120,map00620,map01120 - R00704,R11591 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1620448_2 322710.Avin_39320 3.58e-41 141.0 COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,1S3WJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Deacetylates O-acetyl-ADP ribose. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization activation ymdB GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0008150,GO:0008428,GO:0009892,GO:0010605,GO:0016787,GO:0019213,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0043086,GO:0043900,GO:0044092,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0061463,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1900190,GO:1900231 - - - - - - - - - - Macro k59_157470_1 266117.Rxyl_3138 5.82e-63 204.0 COG1533@1|root,COG1533@2|Bacteria,2GM31@201174|Actinobacteria,4CQAG@84995|Rubrobacteria 84995|Rubrobacteria L Radical SAM - - - - - - - - - - - - Radical_SAM k59_314578_1 69395.JQLZ01000005_gene3833 7.56e-73 229.0 COG0451@1|root,COG0451@2|Bacteria,1MWVE@1224|Proteobacteria,2TS8F@28211|Alphaproteobacteria 28211|Alphaproteobacteria GM NAD-dependent epimerase dehydratase MA20_16995 - 1.1.1.203 ko:K18981 ko00053,map00053 - R10841 RC00066 ko00000,ko00001,ko01000 - - - Epimerase k59_576407_1 105559.Nwat_1237 1.69e-93 286.0 COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,1RNZF@1236|Gammaproteobacteria,1WXRH@135613|Chromatiales 135613|Chromatiales S PFAM Bile acid sodium symporter - - - ko:K03453 - - - - ko00000 2.A.28 - - SBF k59_941961_1 530564.Psta_3687 3.58e-08 56.6 COG1319@1|root,COG1319@2|Bacteria,2IYV7@203682|Planctomycetes 203682|Planctomycetes C COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM CutM homologs - - 1.17.1.4,1.2.5.3 ko:K03519,ko:K11178 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103,R11168 RC00143,RC02800 ko00000,ko00001,ko00002,ko01000 - - - CO_deh_flav_C,FAD_binding_5 k59_1046715_2 1469245.JFBG01000037_gene1851 1.28e-87 261.0 COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,1S43F@1236|Gammaproteobacteria 1236|Gammaproteobacteria I dehydratase - - 4.2.1.56 ko:K18290 ko00660,map00660 - R02491 RC00730 ko00000,ko00001,ko01000 - - - MaoC_dehydratas k59_629301_2 444878.E3SQZ8_9CAUD 1.55e-59 184.0 4QBFG@10239|Viruses,4QPJD@28883|Caudovirales 28883|Caudovirales S 2 iron, 2 sulfur cluster binding - - - - - - - - - - - - - k59_1464725_1 330214.NIDE0836 2.14e-111 340.0 COG1048@1|root,COG1048@2|Bacteria,3J0E6@40117|Nitrospirae 40117|Nitrospirae C Aconitase C-terminal domain - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_524352_1 644966.Tmar_1567 3.7e-25 105.0 COG2378@1|root,COG2378@2|Bacteria,1TT23@1239|Firmicutes,248A8@186801|Clostridia,3WDF9@538999|Clostridiales incertae sedis 186801|Clostridia K WYL domain - - - ko:K13572 - - - - ko00000,ko03051 - - - HTH_11,WYL k59_524352_2 870187.Thini_2729 3.06e-26 104.0 arCOG03638@1|root,2Z7NN@2|Bacteria,1R3Y6@1224|Proteobacteria,1RTWY@1236|Gammaproteobacteria,460KA@72273|Thiotrichales 72273|Thiotrichales S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_629304_1 1282876.BAOK01000001_gene987 3.21e-08 61.6 2CCBE@1|root,33P4Q@2|Bacteria,1NPK9@1224|Proteobacteria,2UV3K@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_471715_2 1123023.JIAI01000002_gene4683 2.52e-147 425.0 COG3616@1|root,COG3616@2|Bacteria,2GK0N@201174|Actinobacteria,4E1C7@85010|Pseudonocardiales 201174|Actinobacteria E Putative serine dehydratase domain - - - - - - - - - - - - Ala_racemase_N,D-ser_dehydrat k59_471715_3 1089552.KI911559_gene1437 5.85e-41 137.0 COG3785@1|root,COG3785@2|Bacteria,1RHM7@1224|Proteobacteria,2U9MS@28211|Alphaproteobacteria,2JTI6@204441|Rhodospirillales 204441|Rhodospirillales S Hemimethylated DNA-binding protein YccV like - - - ko:K11940 - - - - ko00000,ko03036 - - - YccV-like k59_263229_1 765911.Thivi_1325 4.08e-68 217.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNN9@1236|Gammaproteobacteria,1WWN7@135613|Chromatiales 135613|Chromatiales OU PFAM peptidase - - - ko:K04774 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49,Peptidase_S49_N k59_419885_1 1144275.COCOR_06090 5.69e-94 286.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,2YTZH@29|Myxococcales 28221|Deltaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_681543_1 391625.PPSIR1_30065 9.2e-16 77.8 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,42MV3@68525|delta/epsilon subdivisions,2WJZB@28221|Deltaproteobacteria,2YX5W@29|Myxococcales 28221|Deltaproteobacteria L DNA helicase - - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_1099070_1 1452718.JBOY01000055_gene1733 6.65e-30 111.0 COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,1T06D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_1099070_2 1123261.AXDW01000010_gene363 1.3e-22 96.3 COG1704@1|root,COG1704@2|Bacteria,1RDUH@1224|Proteobacteria,1S2KR@1236|Gammaproteobacteria,1XDGA@135614|Xanthomonadales 135614|Xanthomonadales S E3 Ubiquitin ligase - - - - - - - - - - - - GIDE k59_158068_1 1120705.FG95_02642 6.57e-12 66.6 COG1309@1|root,COG1309@2|Bacteria,1N208@1224|Proteobacteria,2UDE9@28211|Alphaproteobacteria,2K5RD@204457|Sphingomonadales 204457|Sphingomonadales K transcriptional regulator - - - - - - - - - - - - TetR_N k59_158068_2 1282876.BAOK01000002_gene544 2.69e-103 314.0 COG2130@1|root,COG2130@2|Bacteria,1MUR0@1224|Proteobacteria,2U16B@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF2855) - - - - - - - - - - - - DUF2855 k59_1256020_1 330214.NIDE1868 1.26e-115 363.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3J0UH@40117|Nitrospirae 40117|Nitrospirae H Pterin binding enzyme - - 2.1.1.13,2.1.1.258 ko:K00548,ko:K15023 ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230 M00017,M00377 R00946,R02289,R09365,R10243 RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans k59_1568802_1 436308.Nmar_1654 3.05e-43 146.0 COG1121@1|root,arCOG00201@2157|Archaea,41S7E@651137|Thaumarchaeota 651137|Thaumarchaeota E PFAM ABC transporter - - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran k59_1568802_2 436308.Nmar_1653 2.36e-52 171.0 COG1108@1|root,arCOG01006@2157|Archaea,41SG2@651137|Thaumarchaeota 651137|Thaumarchaeota P ABC 3 transport family - - - ko:K09816 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_210956_1 1415778.JQMM01000001_gene1970 1.42e-93 298.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1J4MP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind k59_733379_1 187272.Mlg_1353 3.02e-67 212.0 COG3298@1|root,COG3298@2|Bacteria,1MVZJ@1224|Proteobacteria,1S4HU@1236|Gammaproteobacteria,1X0C4@135613|Chromatiales 135613|Chromatiales L 3'-5' exonuclease - - - ko:K07501 - - - - ko00000 - - - DNA_pol_B_exo2 k59_1568806_2 1123401.JHYQ01000026_gene3278 6.06e-28 110.0 COG0727@1|root,COG0727@2|Bacteria,1R3YG@1224|Proteobacteria,1RQT5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_785973_1 298654.FraEuI1c_1338 5.47e-82 256.0 2DBBP@1|root,2Z88Z@2|Bacteria,2I46Q@201174|Actinobacteria 201174|Actinobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_994150_1 296591.Bpro_4324 6.85e-51 169.0 COG2220@1|root,COG2220@2|Bacteria,1MUY6@1224|Proteobacteria,2VM81@28216|Betaproteobacteria,4AGC0@80864|Comamonadaceae 28216|Betaproteobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_3 k59_524378_1 1454004.AW11_01686 4.02e-56 191.0 COG1295@1|root,COG1959@1|root,COG1295@2|Bacteria,COG1959@2|Bacteria,1QICW@1224|Proteobacteria,2VPV7@28216|Betaproteobacteria 28216|Betaproteobacteria K Virulence factor BrkB - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_315527_1 388051.AUFE01000018_gene181 2.29e-16 79.3 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2VIQT@28216|Betaproteobacteria,1KBQ6@119060|Burkholderiaceae 28216|Betaproteobacteria I Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_315527_2 247633.GP2143_13036 1.96e-53 180.0 COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,1RPNI@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG1960 Acyl-CoA dehydrogenases - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1307597_1 713586.KB900536_gene2578 9.1e-56 185.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - - - - - - - - - - T2SSE k59_54756_1 631362.Thi970DRAFT_02339 2e-53 182.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1WWFQ@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_890182_1 203122.Sde_3547 7.11e-47 165.0 28HN6@1|root,2Z7WJ@2|Bacteria,1R5QB@1224|Proteobacteria,1RNJN@1236|Gammaproteobacteria,4667S@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_106177_1 871585.BDGL_001675 6.39e-178 513.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,3NJ4P@468|Moraxellaceae 1236|Gammaproteobacteria F Bifunctional purine biosynthesis protein PurH purH GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - iEcHS_1320.EcHS_A4240,iPC815.YPO3728 AICARFT_IMPCHas,MGS k59_942014_1 1123242.JH636435_gene2850 2.35e-22 96.7 COG1915@1|root,COG1915@2|Bacteria,2IWVZ@203682|Planctomycetes 203682|Planctomycetes S PFAM LOR SDH bifunctional - - - - - - - - - - - - Saccharop_dh_N k59_942014_2 251221.35212324 6.96e-31 122.0 COG1834@1|root,COG1915@1|root,COG1834@2|Bacteria,COG1915@2|Bacteria,1G2AU@1117|Cyanobacteria 1117|Cyanobacteria E PFAM LOR SDH bifunctional enzyme conserved region - - - - - - - - - - - - Amidinotransf,Saccharop_dh_N k59_1568831_1 2340.JV46_14330 3.49e-41 153.0 COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_1203923_1 1432055.GLUCORHAEAF1_15600 4.17e-146 424.0 COG5433@1|root,COG5433@2|Bacteria,1MY25@1224|Proteobacteria,2U0Y8@28211|Alphaproteobacteria 28211|Alphaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_4 k59_629362_1 1463864.JOGO01000026_gene2792 7.29e-73 232.0 COG2175@1|root,COG2175@2|Bacteria,2GNUC@201174|Actinobacteria 201174|Actinobacteria Q taurine catabolism dioxygenase - - 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_629362_2 469383.Cwoe_2086 2.03e-50 169.0 COG1028@1|root,COG1028@2|Bacteria,2HF4J@201174|Actinobacteria,4CSXD@84995|Rubrobacteria 84995|Rubrobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_367832_1 1379270.AUXF01000005_gene582 6.72e-05 52.0 COG0697@1|root,COG2976@1|root,COG0697@2|Bacteria,COG2976@2|Bacteria,1ZT9A@142182|Gemmatimonadetes 142182|Gemmatimonadetes EG Protein of unknown function (DUF2723) - - - - - - - - - - - - DUF2723 k59_576471_1 436308.Nmar_1794 4.28e-144 439.0 COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC - 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - PolC_DP2 k59_419930_1 247490.KSU1_C0747 2.66e-27 115.0 COG0569@1|root,COG0569@2|Bacteria,2IXXC@203682|Planctomycetes 203682|Planctomycetes C TRK potassium uptake system protein (TrkA-2) trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_54771_2 1449068.JMLQ01000004_gene1225 2.12e-16 81.6 COG0406@1|root,COG0406@2|Bacteria,2GJYU@201174|Actinobacteria,4FV69@85025|Nocardiaceae 201174|Actinobacteria G Belongs to the phosphoglycerate mutase family gpmB GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237 3.1.3.85,5.4.2.11 ko:K01834,ko:K22306 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_54771_3 313624.NSP_2390 3.24e-27 110.0 COG0365@1|root,COG0365@2|Bacteria,1G0E7@1117|Cyanobacteria,1HM2H@1161|Nostocales 1117|Cyanobacteria H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1412083_1 1220535.IMCC14465_17600 1.71e-12 73.2 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TXAW@28211|Alphaproteobacteria,4BS2F@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_890199_1 96561.Dole_1446 4.62e-23 98.6 COG0458@1|root,COG0458@2|Bacteria,1NPMZ@1224|Proteobacteria,42NF3@68525|delta/epsilon subdivisions,2WM4C@28221|Deltaproteobacteria,2MIQ1@213118|Desulfobacterales 28221|Deltaproteobacteria F ATP-grasp domain - - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0661 CPSase_L_D2,CPSase_L_D3,MGS k59_374242_2 1469245.JFBG01000014_gene2021 5.4e-63 199.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,1RN6F@1236|Gammaproteobacteria,1WW5F@135613|Chromatiales 135613|Chromatiales C Electron transfer flavoprotein - - - ko:K03521 - - - - ko00000 - - - ETF k59_1105686_1 1265503.KB905164_gene1922 6.2e-18 88.6 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S720@1236|Gammaproteobacteria,2Q7V0@267889|Colwelliaceae 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_11,TPR_16,TPR_19,TPR_2,TPR_8,Trans_reg_C k59_638534_1 1183438.GKIL_2303 1.15e-37 132.0 COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria 1117|Cyanobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_638534_2 754476.Q7A_526 6.64e-34 120.0 2E0T4@1|root,32WAV@2|Bacteria,1N19Z@1224|Proteobacteria,1SBDA@1236|Gammaproteobacteria,462XP@72273|Thiotrichales 72273|Thiotrichales - - - - - - - - - - - - - - - k59_638534_3 556269.ACDQ01000011_gene344 1.89e-15 73.2 COG0494@1|root,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,2VHTP@28216|Betaproteobacteria,4749S@75682|Oxalobacteraceae 28216|Betaproteobacteria L Belongs to the Nudix hydrolase family mutT - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX,TMP-TENI k59_795366_2 981336.F944_02434 1.96e-20 90.5 COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,1RR1C@1236|Gammaproteobacteria,3NIWT@468|Moraxellaceae 1236|Gammaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_163834_1 1207063.P24_03900 1.09e-110 327.0 COG2988@1|root,COG2988@2|Bacteria,1QW6K@1224|Proteobacteria,2TWQ0@28211|Alphaproteobacteria,2JYWE@204441|Rhodospirillales 204441|Rhodospirillales E Succinylglutamate desuccinylase / Aspartoacylase family - - - - - - - - - - - - AstE_AspA k59_638535_1 444860.E3SJ59_9CAUD 6.34e-67 204.0 4QE3P@10239|Viruses,4QX79@35237|dsDNA viruses no RNA stage,4QSZ8@28883|Caudovirales,4QK0B@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_638535_3 444878.E3SR77_9CAUD 1.55e-06 51.6 4QEFB@10239|Viruses,4QVK4@35237|dsDNA viruses no RNA stage,4QU8W@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_218161_1 1380386.JIAW01000007_gene4011 2.17e-22 93.2 COG1309@1|root,COG1309@2|Bacteria,2GJZT@201174|Actinobacteria,237ZP@1762|Mycobacteriaceae 201174|Actinobacteria K tetR family - - - - - - - - - - - - TetR_N k59_1314680_1 1242864.D187_010180 5.12e-09 56.2 COG0848@1|root,COG0848@2|Bacteria,1Q1RQ@1224|Proteobacteria,437EZ@68525|delta/epsilon subdivisions,2X2MA@28221|Deltaproteobacteria,2Z03D@29|Myxococcales 28221|Deltaproteobacteria U Biopolymer transport protein - - - ko:K03559,ko:K03560 - - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - ExbD k59_1314680_2 926566.Terro_0063 1.42e-32 122.0 COG0811@1|root,COG0811@2|Bacteria,3Y2M4@57723|Acidobacteria,2JI9T@204432|Acidobacteriia 204432|Acidobacteriia U MotA TolQ ExbB proton channel - - - ko:K03561,ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - MotA_ExbB k59_163836_2 483219.LILAB_05710 5.12e-40 139.0 COG3428@1|root,COG3428@2|Bacteria 2|Bacteria S Bacterial PH domain ydbT - - ko:K08981 - - - - ko00000 - - - bPH_2 k59_1473323_1 132113.XP_003492781.1 1.03e-53 187.0 COG2377@1|root,2QUN9@2759|Eukaryota,39RYP@33154|Opisthokonta,3BMM5@33208|Metazoa,3DQQZ@33213|Bilateria,426XQ@6656|Arthropoda,3SMSE@50557|Insecta 33208|Metazoa O Anhydro-N-acetylmuramic acid kinase - - - - - - - - - - - - AnmK k59_1265273_1 713586.KB900536_gene836 1.91e-308 874.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1WW62@135613|Chromatiales 135613|Chromatiales L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1367358_1 1324957.K933_16497 2.64e-28 118.0 COG3119@1|root,arCOG02785@2157|Archaea,2XV54@28890|Euryarchaeota,23UWR@183963|Halobacteria 183963|Halobacteria P COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - Sulfatase k59_64006_1 172088.AUGA01000004_gene3892 4.45e-33 133.0 COG2114@1|root,COG2909@1|root,COG3899@1|root,COG2114@2|Bacteria,COG2909@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - AAA_16,Guanylate_cyc,TPR_4 k59_113002_1 502025.Hoch_4785 1.07e-46 166.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,42NXB@68525|delta/epsilon subdivisions,2WMBF@28221|Deltaproteobacteria,2YV6N@29|Myxococcales 28221|Deltaproteobacteria E Membrane dipeptidase (Peptidase family M19) - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_740304_1 316274.Haur_1095 4e-54 186.0 COG0405@1|root,COG0405@2|Bacteria,2G5R2@200795|Chloroflexi,374X4@32061|Chloroflexia 32061|Chloroflexia E PFAM gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1157996_1 1469245.JFBG01000003_gene404 1.74e-47 169.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1WWY6@135613|Chromatiales 135613|Chromatiales U Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 k59_638549_1 118797.XP_007468251.1 6.87e-104 337.0 COG0085@1|root,KOG0214@2759|Eukaryota 2759|Eukaryota K DNA-directed 5'-3' RNA polymerase activity rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0030880,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043,ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_427156_1 266117.Rxyl_3138 2.49e-87 268.0 COG1533@1|root,COG1533@2|Bacteria,2GM31@201174|Actinobacteria,4CQAG@84995|Rubrobacteria 84995|Rubrobacteria L Radical SAM - - - - - - - - - - - - Radical_SAM k59_1419689_1 1162668.LFE_1943 3.68e-58 192.0 COG0821@1|root,COG0821@2|Bacteria,3J0EA@40117|Nitrospirae 40117|Nitrospirae I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_1054083_1 313603.FB2170_14683 3.09e-61 200.0 COG0604@1|root,COG0604@2|Bacteria,4NEYW@976|Bacteroidetes,1HYX1@117743|Flavobacteriia,2PI5I@252356|Maribacter 976|Bacteroidetes C Alcohol dehydrogenase GroES-like domain - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2,MaoC_dehydratas k59_1575758_1 1121428.DESHY_20163___1 3.95e-10 58.5 COG0589@1|root,COG0589@2|Bacteria,1VBRV@1239|Firmicutes 1239|Firmicutes T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp k59_1575758_2 477974.Daud_1945 6.98e-05 48.1 COG0589@1|root,COG0589@2|Bacteria 2|Bacteria T AMP binding usp22 - - - - - - - - - - - Usp k59_1575758_3 436308.Nmar_0016 7.75e-38 127.0 arCOG10511@1|root,arCOG10511@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1575758_4 981336.F944_01389 1.15e-15 76.3 COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,1S6HB@1236|Gammaproteobacteria,3NNMS@468|Moraxellaceae 1236|Gammaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_1628701_1 580332.Slit_1701 1.25e-09 62.8 COG1416@1|root,COG5662@1|root,COG1416@2|Bacteria,COG5662@2|Bacteria,1MYMK@1224|Proteobacteria,2VTJT@28216|Betaproteobacteria 28216|Betaproteobacteria K AntiSigma factor - - - - - - - - - - - - - k59_1001042_1 1229909.NSED_09050 5.25e-26 103.0 COG1527@1|root,arCOG02459@2157|Archaea,41T18@651137|Thaumarchaeota 651137|Thaumarchaeota C ATP synthase (C/AC39) subunit - - - ko:K02119 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_AC39 k59_1001042_2 1229909.NSED_09060 4.64e-05 44.3 COG1468@1|root,arCOG00790@2157|Archaea,41T4T@651137|Thaumarchaeota 651137|Thaumarchaeota V CRISPR-associated protein Cas4 - - 3.1.12.1 ko:K07464 - - - - ko00000,ko01000,ko02048 - - - - k59_897446_1 575589.HMPREF0018_01396 3.41e-67 216.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,3NKE8@468|Moraxellaceae 1236|Gammaproteobacteria E DegT/DnrJ/EryC1/StrS aminotransferase family aspC - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_897446_2 1123368.AUIS01000009_gene2497 4.5e-99 308.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,2NBVX@225057|Acidithiobacillales 225057|Acidithiobacillales L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_479622_1 765912.Thimo_0389 8.15e-86 265.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1WWRH@135613|Chromatiales 1236|Gammaproteobacteria G Fructose-bisphosphate aldolase, class II, Calvin cycle subtype - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - Dabb,F_bP_aldolase k59_1367388_1 314345.SPV1_10571 9.94e-56 179.0 28JNX@1|root,2Z9F0@2|Bacteria,1RGTM@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_690140_1 1232410.KI421421_gene3631 7.73e-70 228.0 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,42MNS@68525|delta/epsilon subdivisions,2WSQX@28221|Deltaproteobacteria 28221|Deltaproteobacteria C ATP ADP translocase - - - ko:K03301 - - - - ko00000 2.A.12 - - MFS_1,TLC k59_897449_1 330214.NIDE4367 7.53e-73 233.0 COG0312@1|root,COG0312@2|Bacteria 2|Bacteria S metallopeptidase activity tldE2 - - - - - - - - - - - PmbA_TldD k59_270540_1 1118235.CAJH01000067_gene3601 2.39e-16 73.2 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,1X7EI@135614|Xanthomonadales 135614|Xanthomonadales J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_270540_2 87626.PTD2_10393 5.54e-10 56.6 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,2Q3DD@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_113033_1 686340.Metal_0291 3.12e-24 96.3 COG0664@1|root,COG0664@2|Bacteria,1PSVZ@1224|Proteobacteria,1TGQD@1236|Gammaproteobacteria,1XGAZ@135618|Methylococcales 135618|Methylococcales T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_4429_1 326297.Sama_0375 1.17e-41 155.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,2QAUE@267890|Shewanellaceae 1236|Gammaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - e_coli_core.b0114,iAF1260.b0114,iBWG_1329.BWG_0107,iE2348C_1286.E2348C_0117,iEC55989_1330.EC55989_0107,iECDH10B_1368.ECDH10B_0094,iECDH1ME8569_1439.ECDH1ME8569_0108,iECH74115_1262.ECH74115_0121,iECIAI1_1343.ECIAI1_0112,iECNA114_1301.ECNA114_0106,iECO103_1326.ECO103_0114,iECO111_1330.ECO111_0115,iECO26_1355.ECO26_0116,iECSE_1348.ECSE_0114,iECSF_1327.ECSF_0127,iECSP_1301.ECSP_0115,iECUMN_1333.ECUMN_0111,iECW_1372.ECW_m0111,iECs_1301.ECs0118,iEKO11_1354.EKO11_3802,iETEC_1333.ETEC_0110,iEcDH1_1363.EcDH1_3488,iEcE24377_1341.EcE24377A_0116,iEcHS_1320.EcHS_A0118,iEcSMS35_1347.EcSMS35_0124,iEcolC_1368.EcolC_3545,iG2583_1286.G2583_0118,iJO1366.b0114,iJR904.b0114,iUMNK88_1353.UMNK88_112,iWFL_1372.ECW_m0111,iY75_1357.Y75_RS00580,iZ_1308.Z0124 Transketolase_N k59_845071_1 580332.Slit_2357 9.82e-18 89.4 COG0457@1|root,COG3071@1|root,COG0457@2|Bacteria,COG3071@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,44VNS@713636|Nitrosomonadales 28216|Betaproteobacteria H Tetratricopeptide repeats - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 k59_740339_2 1123261.AXDW01000015_gene3403 3.34e-15 79.0 COG0457@1|root,COG0457@2|Bacteria,1R50I@1224|Proteobacteria,1RSP6@1236|Gammaproteobacteria,1X4AC@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide repeat - - - - - - - - - - - - - k59_638591_1 525904.Tter_1226 2.43e-95 291.0 COG0492@1|root,COG0492@2|Bacteria,2NNS7@2323|unclassified Bacteria 2|Bacteria O Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 ko:K00384,ko:K03671 ko00450,ko04621,ko05418,map00450,map04621,map05418 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000,ko03110 - - iNJ661.Rv3913 Pyr_redox_2 k59_948893_1 1229909.NSED_08040 5.57e-38 140.0 COG0525@1|root,arCOG00808@2157|Archaea,41SBK@651137|Thaumarchaeota 651137|Thaumarchaeota J Anticodon-binding domain of tRNA - - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_948893_2 1229909.NSED_08035 3.09e-162 457.0 COG0720@1|root,arCOG02172@2157|Archaea,41SY8@651137|Thaumarchaeota 651137|Thaumarchaeota H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_795438_1 450851.PHZ_c1222 5.85e-62 209.0 COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,2U55H@28211|Alphaproteobacteria 28211|Alphaproteobacteria F P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_1575779_1 243233.MCA3004 1.19e-81 259.0 COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1NR3M@1224|Proteobacteria,1T1WT@1236|Gammaproteobacteria,1XGD0@135618|Methylococcales 135618|Methylococcales P Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_218217_1 1500257.JQNM01000014_gene2919 6.47e-146 422.0 COG4638@1|root,COG4638@2|Bacteria,1MX47@1224|Proteobacteria,2TV03@28211|Alphaproteobacteria,4B9MF@82115|Rhizobiaceae 28211|Alphaproteobacteria P Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_479654_1 426117.M446_1252 6.1e-89 271.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2TRP3@28211|Alphaproteobacteria,1JQPA@119045|Methylobacteriaceae 28211|Alphaproteobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_1367410_1 1380394.JADL01000014_gene198 2.62e-11 63.5 COG0715@1|root,COG0715@2|Bacteria,1MWJF@1224|Proteobacteria,2TT19@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - NMT1_2 k59_1367410_2 981336.F944_01516 3.64e-30 110.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,3NN4E@468|Moraxellaceae 1236|Gammaproteobacteria O Belongs to the MsrB Met sulfoxide reductase family msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_897469_1 398527.Bphyt_4369 1.2e-108 330.0 COG0028@1|root,COG0028@2|Bacteria,1MWUB@1224|Proteobacteria,2VMC1@28216|Betaproteobacteria,1K2XV@119060|Burkholderiaceae 28216|Betaproteobacteria EH Belongs to the TPP enzyme family xsc - 2.3.3.15 ko:K03852 ko00430,map00430 - R05651 RC02903,RC02909 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_218219_1 47839.CCAU010000002_gene2449 2.72e-21 98.2 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,2GKBW@201174|Actinobacteria,237C1@1762|Mycobacteriaceae 201174|Actinobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.8 ko:K00179,ko:K04090 - - - - br01601,ko00000,ko01000 - - - Fer4,POR,POR_N,TPP_enzyme_C k59_1521067_1 525897.Dbac_1078 2.97e-69 215.0 COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,42S9D@68525|delta/epsilon subdivisions,2WNWH@28221|Deltaproteobacteria 28221|Deltaproteobacteria S (twin-arginine translocation) pathway signal - - - - - - - - - - - - - k59_845087_1 1430440.MGMSRv2_0791 2.95e-57 198.0 COG2176@1|root,COG5002@1|root,COG2176@2|Bacteria,COG5002@2|Bacteria,1QUVW@1224|Proteobacteria,2TSZS@28211|Alphaproteobacteria,2JRKH@204441|Rhodospirillales 204441|Rhodospirillales LT EXOIII - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_1001082_1 926569.ANT_05360 4.53e-46 167.0 COG1243@1|root,COG1243@2|Bacteria,2G5ZZ@200795|Chloroflexi 200795|Chloroflexi BK Radical_SAM C-terminal domain - - 2.3.1.48 ko:K07739 - - - - ko00000,ko01000,ko03016,ko03036 - - - Acetyltransf_1,Radical_SAM,Radical_SAM_C k59_1473409_1 589865.DaAHT2_0463 2.88e-11 68.6 COG5373@1|root,COG5373@2|Bacteria,1QZY0@1224|Proteobacteria,42XBF@68525|delta/epsilon subdivisions,2WSP1@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Type II secretion system protein B - - - ko:K02451 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - T2SSB k59_1265364_1 261292.Nit79A3_2628 1.31e-60 195.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VJ2B@28216|Betaproteobacteria,371R7@32003|Nitrosomonadales 28216|Betaproteobacteria V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_163906_1 330214.NIDE3255 5.15e-31 127.0 COG0243@1|root,COG0243@2|Bacteria 2|Bacteria C molybdopterin cofactor binding ddhA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4 ko:K00370,ko:K10700,ko:K16964,ko:K17050 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_583686_1 56780.SYN_01965 2.02e-66 221.0 COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,42YQ4@68525|delta/epsilon subdivisions,2WTPM@28221|Deltaproteobacteria 28221|Deltaproteobacteria EH PFAM Thiamine pyrophosphate - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_N k59_1419760_1 768671.ThimaDRAFT_0284 1.67e-13 71.2 COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1RPTU@1236|Gammaproteobacteria,1WXF3@135613|Chromatiales 135613|Chromatiales I Membrane protein involved in aromatic hydrocarbon degradation - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_1158051_2 472759.Nhal_0303 2.55e-78 235.0 COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,1S1HV@1236|Gammaproteobacteria 1236|Gammaproteobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_163911_1 1274374.CBLK010000079_gene4042 3.19e-51 173.0 COG1028@1|root,COG1028@2|Bacteria,1UYD2@1239|Firmicutes,4HU47@91061|Bacilli,274QF@186822|Paenibacillaceae 91061|Bacilli IQ 3-ketoacyl-ACP reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_270586_2 445684.E3SQ72_9CAUD 1.38e-46 159.0 4QGYD@10239|Viruses,4QVN8@35237|dsDNA viruses no RNA stage,4QS47@28883|Caudovirales,4QJQ7@10662|Myoviridae 10662|Myoviridae S pentose-phosphate shunt - - - - - - - - - - - - - k59_1473433_1 926562.Oweho_1925 4.21e-26 114.0 COG4531@1|root,COG4531@2|Bacteria,4NF0R@976|Bacteroidetes,1HY1X@117743|Flavobacteriia,2PAAV@246874|Cryomorphaceae 976|Bacteroidetes P Quinol cytochrome c oxidoreductase actF - - - - - - - - - - - - k59_897503_3 1459636.NTE_01122 1.1e-09 57.0 COG0783@1|root,arCOG01101@2157|Archaea 2157|Archaea P Belongs to the Dps family frt - - ko:K04047 - - - - ko00000,ko03036 - - - Ferritin k59_1213248_1 1121897.AUGO01000008_gene2707 1.13e-10 60.8 COG0745@1|root,COG0745@2|Bacteria,4NQNT@976|Bacteroidetes,1I3AQ@117743|Flavobacteriia,2NWVA@237|Flavobacterium 976|Bacteroidetes KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_1213248_2 1131266.ARWQ01000011_gene103 1.9e-44 145.0 arCOG07440@1|root,arCOG07440@2157|Archaea,41STP@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1213248_3 436308.Nmar_0658 9.3e-61 199.0 COG0008@1|root,arCOG00402@2157|Archaea,41SFI@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b k59_218258_1 1384056.N787_07055 5.2e-05 48.1 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1X4FV@135614|Xanthomonadales 135614|Xanthomonadales C IG-like fold at C-terminal of FixG, putative oxidoreductase - - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_218258_2 395493.BegalDRAFT_1783 1e-15 75.1 COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,1SC87@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria ccoH - - ko:K09926 - - - - ko00000 - - - FixH k59_375135_1 1203554.HMPREF1476_02137 1.01e-18 90.5 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,4PQBI@995019|Sutterellaceae 28216|Betaproteobacteria M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_427239_1 225937.HP15_2086 2.98e-85 265.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,464B7@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_590736_1 575540.Isop_1559 3.31e-41 152.0 COG0303@1|root,COG0303@2|Bacteria,2IY2T@203682|Planctomycetes 203682|Planctomycetes H MoeA N-terminal region (domain I and II) - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1061491_1 398527.Bphyt_0984 2.64e-53 184.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2VH79@28216|Betaproteobacteria,1K141@119060|Burkholderiaceae 28216|Betaproteobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_904570_1 1121937.AUHJ01000003_gene3196 1.17e-16 85.1 2DBIM@1|root,2Z9G7@2|Bacteria,1P7UF@1224|Proteobacteria,1S0KE@1236|Gammaproteobacteria,46CGV@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF560) - - - - - - - - - - - - DUF560 k59_277882_1 1121957.ATVL01000012_gene853 5.18e-14 76.3 COG1621@1|root,COG1621@2|Bacteria,4NJYV@976|Bacteroidetes,47XB9@768503|Cytophagia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - Glyco_hydro_32N,Glyco_hydro_43 k59_383605_1 1192034.CAP_7405 9.86e-98 297.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2WJB0@28221|Deltaproteobacteria,2YWEI@29|Myxococcales 28221|Deltaproteobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_383605_2 595460.RRSWK_01252 3.26e-12 66.2 COG0531@1|root,COG0531@2|Bacteria,2IX7G@203682|Planctomycetes 203682|Planctomycetes E Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_697203_2 1499967.BAYZ01000073_gene2027 1.26e-36 131.0 COG0118@1|root,COG0118@2|Bacteria,2NPQ1@2323|unclassified Bacteria 2|Bacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K01663,ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase,His_biosynth k59_330377_1 396588.Tgr7_1277 5.16e-83 256.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,1WX20@135613|Chromatiales 135613|Chromatiales O TIGRFAM hydrogenase expression formation protein HypE - - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_434415_1 1123393.KB891316_gene1395 5.94e-58 189.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,1KRH1@119069|Hydrogenophilales 119069|Hydrogenophilales U Peptidase S24-like - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_1482658_1 246200.SPO3036 7.22e-205 585.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2TSM1@28211|Alphaproteobacteria,4ND2Q@97050|Ruegeria 28211|Alphaproteobacteria Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_1274750_1 1307436.PBF_14684 6.34e-32 124.0 COG3547@1|root,COG3547@2|Bacteria,1V427@1239|Firmicutes,4HGY6@91061|Bacilli,1ZERT@1386|Bacillus 91061|Bacilli L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1163868_1 1265313.HRUBRA_02433 1.89e-17 86.7 COG1597@1|root,COG1597@2|Bacteria,1RIZ6@1224|Proteobacteria,1S4KN@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Diacylglycerol kinase catalytic domain - - - - - - - - - - - - DAGK_cat k59_538307_1 349521.HCH_06247 1.47e-15 71.6 COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,1S5XY@1236|Gammaproteobacteria,1XJHW@135619|Oceanospirillales 135619|Oceanospirillales S membrane - - - ko:K08973 - - - - ko00000 - - - UPF0093 k59_1428985_1 1173026.Glo7428_0932 9.42e-18 88.2 COG1216@1|root,COG5309@1|root,COG1216@2|Bacteria,COG5309@2|Bacteria,1G2MT@1117|Cyanobacteria 1117|Cyanobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_hydro_2_C,Glycos_transf_2 k59_852150_1 349124.Hhal_1500 1.52e-92 291.0 COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,1X0IX@135613|Chromatiales 135613|Chromatiales S PFAM peptidase S15 - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_1061530_2 1229780.BN381_10279 0.000454 44.7 COG1020@1|root,COG1020@2|Bacteria,2GKU0@201174|Actinobacteria 201174|Actinobacteria Q diacylglycerol O-acyltransferase - - - - - - - - - - - - DUF1298,WES_acyltransf k59_225281_1 393595.ABO_2600 2.61e-85 265.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1XHSG@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the peptidase M24B family pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_1582977_1 1121935.AQXX01000094_gene2764 3.63e-08 53.5 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1XI1E@135619|Oceanospirillales 135619|Oceanospirillales V Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides - - - ko:K02003,ko:K09810 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 - - ABC_tran k59_1582977_2 472759.Nhal_3356 4.79e-103 312.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1WXP0@135613|Chromatiales 135613|Chromatiales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_73288_1 330214.NIDE2915 1.82e-135 395.0 COG0064@1|root,COG0064@2|Bacteria,3J0FK@40117|Nitrospirae 40117|Nitrospirae J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_697244_1 998674.ATTE01000001_gene1577 1.39e-08 55.5 COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,1RMQC@1236|Gammaproteobacteria,45ZQS@72273|Thiotrichales 72273|Thiotrichales F dihydroorotase - - - - - - - - - - - - Amidohydro_1 k59_697244_2 1144343.PMI41_03990 1.55e-57 192.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,43GXI@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C NADPH-dependent glutamate synthase beta preT - 1.3.1.1 ko:K17722 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046 R00977,R01414,R11026 RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,Pyr_redox_2 k59_383662_1 1120978.KB894079_gene719 4.71e-10 62.8 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,4H9TK@91061|Bacilli,27FMC@186828|Carnobacteriaceae 91061|Bacilli S ABC transporter C-terminal domain yfmR - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_1320336_1 472759.Nhal_2426 5.34e-121 363.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1WXIB@135613|Chromatiales 135613|Chromatiales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1220516_1 1384056.N787_13060 1.77e-24 98.6 COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1S8HN@1236|Gammaproteobacteria,1X62E@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_852187_1 1282876.BAOK01000002_gene90 1.58e-14 75.1 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,2TTM2@28211|Alphaproteobacteria,4BQVV@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O Glycoprotease family yeaZ - 2.3.1.234 ko:K01409,ko:K14742 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_904635_1 1397528.Q671_07285 2.68e-61 199.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1XI8M@135619|Oceanospirillales 135619|Oceanospirillales M Arabinose 5-phosphate isomerase kpsF - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_904635_2 1163617.SCD_n00580 2.95e-51 173.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VI81@28216|Betaproteobacteria 28216|Betaproteobacteria V abc transporter ybhF_1 - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1429032_1 1382356.JQMP01000003_gene2354 0.000109 47.4 COG0277@1|root,COG0277@2|Bacteria,2G6FW@200795|Chloroflexi,27XX4@189775|Thermomicrobia 189775|Thermomicrobia C FAD linked oxidases, C-terminal domain - - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 k59_1429032_2 570268.ANBB01000046_gene1361 2.56e-38 147.0 COG0247@1|root,COG0247@2|Bacteria,2GIVX@201174|Actinobacteria,4EHV6@85012|Streptosporangiales 201174|Actinobacteria C 4Fe-4S binding domain glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7,Fer4_8 k59_1163903_1 886293.Sinac_1552 1.59e-27 112.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2IXHK@203682|Planctomycetes 203682|Planctomycetes S Belongs to the CinA family - - 3.5.1.42 ko:K03742 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth k59_1163903_2 378806.STAUR_8052 7.47e-08 54.3 2EV1C@1|root,33NGG@2|Bacteria,1NKKY@1224|Proteobacteria,42X6Y@68525|delta/epsilon subdivisions,2WTH7@28221|Deltaproteobacteria,2Z0VE@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_225323_1 102107.XP_008242501.1 9.63e-71 234.0 COG0281@1|root,KOG1257@2759|Eukaryota,37JSE@33090|Viridiplantae,3G98C@35493|Streptophyta,4JMPI@91835|fabids 35493|Streptophyta C malic enzyme - GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006090,GO:0006108,GO:0008150,GO:0008152,GO:0009507,GO:0009536,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0019752,GO:0022607,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0051259,GO:0051260,GO:0055114,GO:0065003,GO:0071704,GO:0071840 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic k59_1429039_1 1415754.JQMK01000013_gene117 1.35e-20 90.1 COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,1RS6A@1236|Gammaproteobacteria,469SU@72275|Alteromonadaceae 1236|Gammaproteobacteria C C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the intermediary formation of conspicuous sulfur globules inside of the cells soxA - 1.8.2.2 ko:K17222,ko:K19713 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 - - - - k59_1429039_2 1245469.S58_06210 1.22e-23 92.8 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,2U9JC@28211|Alphaproteobacteria,3JZE0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Sulphur oxidation protein SoxZ MA20_22825 - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_489153_1 765914.ThisiDRAFT_2315 5.25e-96 311.0 COG0187@1|root,COG1372@1|root,COG0187@2|Bacteria,COG1372@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_170969_1 981383.AEWH01000046_gene1394 3.24e-47 167.0 COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,4HBYZ@91061|Bacilli 91061|Bacilli J 30S ribosomal protein S12 methylthiotransferase yqeV GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_1583021_1 1177154.Y5S_01884 3.4e-15 75.5 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1XHSG@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the peptidase M24B family pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_590819_1 926569.ANT_18480 4.94e-08 54.3 COG0526@1|root,COG0526@2|Bacteria,2G72F@200795|Chloroflexi 200795|Chloroflexi CO PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA k59_121541_1 203122.Sde_1321 9.14e-41 153.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,465BT@72275|Alteromonadaceae 1236|Gammaproteobacteria S exporters of the RND superfamily VP1286 - - ko:K07003 - - - - ko00000 - - - MMPL k59_1061584_1 1265313.HRUBRA_00553 1.47e-89 271.0 COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,1RMTR@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rfbA GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046379,GO:0046872,GO:0071704,GO:1901576 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - iSDY_1059.SDY_2206,iSF_1195.SF2102,iSFxv_1172.SFxv_2338,iS_1188.S2225 NTP_transferase k59_538371_1 1121434.AULY01000010_gene2349 2.57e-93 282.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2WIQU@28221|Deltaproteobacteria,2M8U2@213115|Desulfovibrionales 28221|Deltaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1163913_1 765910.MARPU_10625 1.23e-63 218.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales 135613|Chromatiales K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_1274838_1 247490.KSU1_B0264 7.42e-27 118.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c soxX - 1.9.3.1 ko:K02275,ko:K17223 ko00190,ko00920,ko01100,ko01120,map00190,map00920,map01100,map01120 M00155,M00595 R00081,R10151 RC00016,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - Cytochrom_C k59_226208_2 1121413.JMKT01000012_gene550 1.22e-17 81.6 COG0543@1|root,COG0543@2|Bacteria,1NTWI@1224|Proteobacteria,42M66@68525|delta/epsilon subdivisions,2WJJ2@28221|Deltaproteobacteria,2M875@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Oxidoreductase FAD NAD(P)-binding nfnB - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - DHODB_Fe-S_bind,NAD_binding_1 k59_853182_1 506534.Rhein_2715 4.9e-40 139.0 COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,1S6IB@1236|Gammaproteobacteria,1WYI3@135613|Chromatiales 135613|Chromatiales S Threonylcarbamoyl adenosine biosynthesis protein TsaE - - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k59_748326_1 1205680.CAKO01000038_gene1868 1.81e-50 174.0 COG1812@1|root,COG1812@2|Bacteria,1QPB9@1224|Proteobacteria,2U1WE@28211|Alphaproteobacteria 28211|Alphaproteobacteria E S-adenosylmethionine synthetase (AdoMet synthetase) - - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_Synthase k59_74507_1 1267533.KB906734_gene4364 9.12e-27 114.0 COG0577@1|root,COG0577@2|Bacteria,3Y64Z@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_331382_1 1220535.IMCC14465_17660 7.9e-50 171.0 COG4638@1|root,COG4638@2|Bacteria,1N3CA@1224|Proteobacteria 1224|Proteobacteria P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - - - - - - - - - - Rieske k59_905638_1 160492.XF_1822 1.35e-13 71.2 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1X35R@135614|Xanthomonadales 135614|Xanthomonadales EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_331383_1 204669.Acid345_2348 1.04e-05 52.8 COG2197@1|root,COG2197@2|Bacteria,3Y54P@57723|Acidobacteria,2JJT9@204432|Acidobacteriia 204432|Acidobacteriia K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_1430212_1 631362.Thi970DRAFT_03835 2.97e-112 337.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1WW94@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_278964_1 388739.RSK20926_00310 6.27e-78 242.0 COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TU4H@28211|Alphaproteobacteria,2P2MS@2433|Roseobacter 28211|Alphaproteobacteria H HpcH/HpaI aldolase/citrate lyase family mclA_1 - 4.1.3.24,4.1.3.25 ko:K08691 ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,map00630,map00660,map00680,map00720,map01120,map01200 M00346,M00373,M00376 R00237,R00473,R00934 RC00307,RC00308,RC00311,RC00407,RC00502,RC01205 ko00000,ko00001,ko00002,ko01000 - - - HpcH_HpaI k59_1483937_1 186497.PF0729 3.09e-16 80.5 COG1145@1|root,COG1456@1|root,arCOG00958@2157|Archaea,arCOG06909@2157|Archaea 2157|Archaea C CO dehydrogenase/acetyl-CoA synthase delta subunit - - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - CdhD,Fer4,PAPS_reduct k59_1483937_2 525897.Dbac_3336 3.17e-07 51.6 COG0135@1|root,COG0135@2|Bacteria,1RA5Q@1224|Proteobacteria,42T4S@68525|delta/epsilon subdivisions,2WP9V@28221|Deltaproteobacteria,2MBPM@213115|Desulfovibrionales 28221|Deltaproteobacteria E Belongs to the TrpF family - - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_591808_1 626887.J057_04356 2.3e-35 136.0 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria,46A56@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K07028 - - - - ko00000 - - - AAA_33,APH k59_591809_1 1121918.ARWE01000001_gene2992 2.15e-33 130.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42N78@68525|delta/epsilon subdivisions,2WM0M@28221|Deltaproteobacteria,43S51@69541|Desulfuromonadales 28221|Deltaproteobacteria M Mechanosensitive ion channel mscS-2 - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_74529_1 247634.GPB2148_990 3.75e-112 344.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1430221_1 1121878.AUGL01000002_gene2346 4.09e-11 68.6 COG0591@1|root,COG0591@2|Bacteria,1R475@1224|Proteobacteria,1RZZD@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family gpuP - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1062575_1 203122.Sde_1256 3.94e-35 133.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,464F1@72275|Alteromonadaceae 1236|Gammaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008301,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0030983,GO:0031323,GO:0032136,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - iECW_1372.ECW_m2935,iWFL_1372.ECW_m2935 MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_384996_1 113395.AXAI01000005_gene3818 2.71e-41 140.0 COG0662@1|root,COG0662@2|Bacteria,1QW6S@1224|Proteobacteria 1224|Proteobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 k59_490376_1 998674.ATTE01000001_gene474 1.48e-58 196.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,45ZS1@72273|Thiotrichales 72273|Thiotrichales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_490376_2 1109445.AGSX01000193_gene456 1.77e-125 375.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1Z244@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M Peptidoglycan polymerase that is essential for cell division ftsW GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505 - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_171704_2 105559.Nwat_2242 2.67e-32 117.0 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1WWUP@135613|Chromatiales 135613|Chromatiales V PFAM N-acetylmuramoyl-L-alanine amidase family 2 - - 3.5.1.28 ko:K03806 - - - - ko00000,ko01000,ko01011 - - - Amidase_2 k59_1637547_1 1121405.dsmv_3089 6.15e-63 205.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,42KZG@68525|delta/epsilon subdivisions,2WIQ5@28221|Deltaproteobacteria,2MIKI@213118|Desulfobacterales 28221|Deltaproteobacteria F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_806296_1 395493.BegalDRAFT_2604 1.53e-46 161.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,45ZXN@72273|Thiotrichales 72273|Thiotrichales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_806296_2 224324.aq_074 1.6e-09 56.2 COG0099@1|root,COG0099@2|Bacteria,2G428@200783|Aquificae 200783|Aquificae J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_435634_2 582515.KR51_00025560 1.54e-18 86.3 COG4301@1|root,COG4301@2|Bacteria,1G2JI@1117|Cyanobacteria 1117|Cyanobacteria S conserved protein (DUF2260) - - - - - - - - - - - - Methyltransf_33 k59_490386_1 436308.Nmar_1488 5.8e-114 344.0 COG0072@1|root,arCOG00412@2157|Archaea,41S8M@651137|Thaumarchaeota 651137|Thaumarchaeota J phenylalanyl-tRNA synthetase, beta subunit - - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5 k59_502512_1 289377.HL41_04695 1.02e-58 205.0 COG1200@1|root,COG1200@2|Bacteria,2GHAE@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_288005_2 713586.KB900536_gene1024 6.23e-34 120.0 COG0316@1|root,COG0316@2|Bacteria,1RKPC@1224|Proteobacteria,1SB76@1236|Gammaproteobacteria,1WYKT@135613|Chromatiales 135613|Chromatiales S Belongs to the HesB IscA family - - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_288005_3 2340.JV46_15400 8.43e-30 117.0 COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,1RR1J@1236|Gammaproteobacteria,1JBRK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H CobB/CobQ-like glutamine amidotransferase domain cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 k59_661365_1 69042.WH5701_15211 3.86e-38 140.0 COG0686@1|root,COG0686@2|Bacteria,1G11E@1117|Cyanobacteria,1GYTX@1129|Synechococcus 1117|Cyanobacteria C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_757269_1 278963.ATWD01000001_gene4270 1.48e-32 130.0 COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,3Y2Y4@57723|Acidobacteria,2JI8D@204432|Acidobacteriia 204432|Acidobacteriia E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroD - 1.1.1.25,4.2.1.10 ko:K13832 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413,R03084 RC00206,RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_I,Shikimate_DH,Shikimate_dh_N k59_1071526_1 391613.RTM1035_09833 2.69e-33 128.0 COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2TRPW@28211|Alphaproteobacteria 28211|Alphaproteobacteria L transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_133394_1 585531.HMPREF0063_12556 1.48e-87 268.0 COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4DPXS@85009|Propionibacteriales 201174|Actinobacteria IQ KR domain hdhA GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136 1.1.1.159 ko:K00076 ko00121,map00121 - - - ko00000,ko00001,ko01000 - - - adh_short_C2 k59_133394_2 68170.KL590510_gene7416 4.63e-06 54.3 COG2267@1|root,COG2267@2|Bacteria,2I4VH@201174|Actinobacteria,4E27R@85010|Pseudonocardiales 201174|Actinobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1 k59_1442057_1 998088.B565_0261 6.03e-92 287.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1Y3NJ@135624|Aeromonadales 135624|Aeromonadales E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_1288466_1 1121948.AUAC01000003_gene2756 8.02e-52 172.0 2DBEE@1|root,2Z8S9@2|Bacteria,1R3R5@1224|Proteobacteria 1224|Proteobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_1442065_1 306281.AJLK01000114_gene4308 1.16e-23 97.8 COG0235@1|root,COG0235@2|Bacteria,1G2EA@1117|Cyanobacteria,1JHFB@1189|Stigonemataceae 1117|Cyanobacteria G Class II Aldolase and Adducin N-terminal domain mtnB - 4.2.1.109 ko:K08964 ko00270,ko01100,map00270,map01100 M00034 R07392 RC01939 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II k59_1442065_2 459495.SPLC1_S208560 2.51e-39 136.0 COG1791@1|root,COG1791@2|Bacteria,1G274@1117|Cyanobacteria,1HAWI@1150|Oscillatoriales 1117|Cyanobacteria S Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway mtnD - 1.13.11.53,1.13.11.54 ko:K08967 ko00270,ko01100,map00270,map01100 M00034 R07363,R07364 RC01866,RC02018,RC02118 ko00000,ko00001,ko00002,ko01000 - - - ARD k59_502532_1 1515746.HR45_09655 9.04e-37 138.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,2Q955@267890|Shewanellaceae 1236|Gammaproteobacteria T Signal transduction histidine kinase, nitrogen specific, NtrB glnL GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_502532_2 543913.D521_1044 4.02e-13 68.2 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2VHYE@28216|Betaproteobacteria,1KQFB@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E Glutamine synthetase, catalytic domain glnA GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360 5.4.4.3,6.3.1.2 ko:K01915,ko:K20712 ko00220,ko00250,ko00627,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00627,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253,R06988,R09284 RC00010,RC01754,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_914840_1 378806.STAUR_2862 2.2e-39 145.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,43EAS@68525|delta/epsilon subdivisions,2X7TI@28221|Deltaproteobacteria 1224|Proteobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_661403_1 1121403.AUCV01000005_gene325 4.36e-09 59.3 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2WKX1@28221|Deltaproteobacteria,2MHZU@213118|Desulfobacterales 28221|Deltaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_661403_2 706587.Desti_1251 1.83e-08 55.5 COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,42VAI@68525|delta/epsilon subdivisions 1224|Proteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_1071553_1 760192.Halhy_5138 5.34e-42 153.0 COG1972@1|root,COG1972@2|Bacteria,4NEYN@976|Bacteroidetes,1IRNQ@117747|Sphingobacteriia 976|Bacteroidetes F Na dependent nucleoside transporter nupC - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_707084_1 765913.ThidrDRAFT_0723 1.4e-56 196.0 COG0501@1|root,COG0501@2|Bacteria,1MVU4@1224|Proteobacteria,1RPJ5@1236|Gammaproteobacteria,1WWWM@135613|Chromatiales 135613|Chromatiales O PFAM peptidase M48 Ste24p - - - - - - - - - - - - Peptidase_M48 k59_965826_1 1303518.CCALI_01496 0.000365 48.1 COG4856@1|root,COG4856@2|Bacteria 2|Bacteria O YbbR-like protein ybbR GO:0008150,GO:0031279,GO:0031281,GO:0043085,GO:0044093,GO:0045761,GO:0045762,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009 - - - - - - - - - - YbbR k59_502573_1 401053.AciPR4_0664 4.81e-98 308.0 COG0442@1|root,COG0442@2|Bacteria,3Y329@57723|Acidobacteria,2JIBQ@204432|Acidobacteriia 204432|Acidobacteriia J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_502586_1 997346.HMPREF9374_0869 1.83e-16 81.3 COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,4HBSG@91061|Bacilli,27B72@186824|Thermoactinomycetaceae 91061|Bacilli O Subunit ChlI of Mg-chelatase comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_502586_2 1121374.KB891575_gene1253 2.54e-22 92.0 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,1S9Z9@1236|Gammaproteobacteria 1236|Gammaproteobacteria C cytochrome c5 cyc - 1.9.3.1 ko:K02277 ko00190,ko01100,map00190,map01100 M00155 - - ko00000,ko00001,ko00002,ko01000 3.D.4.4 - - Cytochrome_CBB3 k59_757332_1 713587.THITH_07385 9.32e-80 257.0 COG0457@1|root,COG0457@2|Bacteria,1QXGV@1224|Proteobacteria 1224|Proteobacteria S ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_707118_1 754476.Q7A_2088 3.39e-72 223.0 COG2259@1|root,COG2259@2|Bacteria,1RBZP@1224|Proteobacteria,1S28E@1236|Gammaproteobacteria,460P8@72273|Thiotrichales 72273|Thiotrichales S DoxX - - - - - - - - - - - - DoxX k59_707118_2 393595.ABO_1424 2.36e-45 160.0 COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RP1C@1236|Gammaproteobacteria,1XH9N@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the glutamate synthase family - - - - - - - - - - - - Glu_synthase k59_340378_1 1537994.JQFW01000015_gene1951 1.87e-30 124.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,465IT@72275|Alteromonadaceae 1236|Gammaproteobacteria I Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities fadJ GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c26730,iETEC_1333.ETEC_2476,iEcE24377_1341.EcE24377A_2637,ic_1306.c2886 3HCDH,3HCDH_N,ECH_1 k59_820008_1 864563.HMPREF9166_0203 1.48e-28 113.0 COG0111@1|root,COG0111@2|Bacteria,1TSDK@1239|Firmicutes,4H2HK@909932|Negativicutes 909932|Negativicutes EH D-isomer specific 2-hydroxyacid dehydrogenase - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C,AdoHcyase_NAD k59_548979_1 1229909.NSED_00210 1.47e-25 103.0 COG0252@1|root,arCOG01924@2157|Archaea,41SD7@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate gatD - 6.3.5.7 ko:K09482 ko00970,ko01100,map00970,map01100 - R03905 RC00010 ko00000,ko00001,ko01000 - - - Asparaginase k59_548979_2 436308.Nmar_0099 3.38e-56 191.0 COG2511@1|root,arCOG01719@2157|Archaea,41S8Q@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate gatE - 6.3.5.7 ko:K03330 ko00970,ko01100,map00970,map01100 - R03905 RC00010 ko00000,ko00001,ko01000 - - - GAD,GatB_N,GatB_Yqey k59_1593961_1 715451.ambt_06015 1.02e-28 117.0 COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria,466S1@72275|Alteromonadaceae 1236|Gammaproteobacteria K Transcriptional regulator hdfR GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - - - - - - - - - - HTH_1,LysR_substrate k59_1593961_2 388399.SSE37_04270 8.48e-22 94.4 COG0189@1|root,COG4067@1|root,COG0189@2|Bacteria,COG4067@2|Bacteria,1MX62@1224|Proteobacteria,2TRUH@28211|Alphaproteobacteria 28211|Alphaproteobacteria HJ Belongs to the RimK family rimK - 6.3.2.32 ko:K05844,ko:K14940 ko00680,ko01120,map00680,map01120 - R09401 RC00064,RC00090 ko00000,ko00001,ko01000,ko03009 - - - RimK,Zn_protease k59_447336_1 633149.Bresu_0661 3.45e-41 152.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,2KFWT@204458|Caulobacterales 204458|Caulobacterales C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_548981_1 1353528.DT23_16025 1.53e-18 86.7 COG0683@1|root,COG0683@2|Bacteria,1R6HB@1224|Proteobacteria,2U0JE@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Periplasmic binding protein domain - - - - - - - - - - - - Peripla_BP_6 k59_548981_2 1209989.TepiRe1_1442 0.000184 43.5 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,42EKB@68295|Thermoanaerobacterales 186801|Clostridia E PFAM aminotransferase, class I aspB - 2.6.1.1 ko:K00812,ko:K10907 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - iHN637.CLJU_RS06550 Aminotran_1_2 k59_179681_1 1499967.BAYZ01000158_gene430 1.77e-64 220.0 COG1200@1|root,COG1200@2|Bacteria,2NNS3@2323|unclassified Bacteria 2|Bacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_662965_1 614083.AWQR01000047_gene3310 3.84e-24 102.0 COG3917@1|root,COG3917@2|Bacteria,1MV6E@1224|Proteobacteria,2W52I@28216|Betaproteobacteria 28216|Betaproteobacteria Q DSBA-like thioredoxin domain - - - - - - - - - - - - DSBA k59_662965_2 1122599.AUGR01000022_gene1647 1.46e-20 87.4 COG0400@1|root,COG0400@2|Bacteria,1QWPI@1224|Proteobacteria 1224|Proteobacteria S carboxylic ester hydrolase activity - - - - - - - - - - - - UPF0227 k59_341679_2 713586.KB900536_gene1317 8.9e-97 291.0 COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RQ57@1236|Gammaproteobacteria,1WZYG@135613|Chromatiales 135613|Chromatiales G Fructose-bisphosphate aldolase class-I - - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic k59_1072908_1 666681.M301_1334 9.98e-114 338.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2VI25@28216|Betaproteobacteria,2KMA0@206350|Nitrosomonadales 206350|Nitrosomonadales I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_758276_1 1283287.KB822575_gene295 0.000277 43.9 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4DN7X@85009|Propionibacteriales 201174|Actinobacteria J Amidase amiC GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_1289961_1 314285.KT71_12215 4.66e-33 131.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - OMP_b-brl_3,Plug,TonB_dep_Rec k59_1497446_1 1392490.JHZX01000001_gene2513 2.39e-26 106.0 COG0451@1|root,COG0451@2|Bacteria,4NEZX@976|Bacteroidetes,1HWT7@117743|Flavobacteriia 976|Bacteroidetes GM PFAM NAD dependent epimerase dehydratase family - - 4.1.1.35 ko:K08678 ko00520,ko01100,map00520,map01100 M00361 R01384 RC00508 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_1443055_1 1304872.JAGC01000005_gene2149 9.3e-41 150.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2WIXI@28221|Deltaproteobacteria,2M7UC@213115|Desulfovibrionales 28221|Deltaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_1443055_2 224324.aq_260 2.01e-31 117.0 COG0779@1|root,COG0779@2|Bacteria,2G46M@200783|Aquificae 200783|Aquificae J Required for maturation of 30S ribosomal subunits rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_1384526_1 444860.E3SJ15_9CAUD 2.77e-52 169.0 4QAQQ@10239|Viruses,4QVZX@35237|dsDNA viruses no RNA stage,4QPBX@28883|Caudovirales,4QIBM@10662|Myoviridae 10662|Myoviridae S T4-like virus tail tube protein gp19 - - - - - - - - - - - - - k59_1384526_2 444860.E3SJ13_9CAUD 2.75e-14 71.6 4QAJ5@10239|Viruses,4QUS9@35237|dsDNA viruses no RNA stage,4QPY5@28883|Caudovirales,4QHUT@10662|Myoviridae 10662|Myoviridae S Major capsid protein Gp23 - GO:0005575,GO:0019012,GO:0019028,GO:0044423 - - - - - - - - - - - k59_289481_1 1094715.CM001373_gene2218 1.26e-24 103.0 COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,1RRRP@1236|Gammaproteobacteria,1JCMG@118969|Legionellales 118969|Legionellales MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1650741_1 1380394.JADL01000020_gene1824 3.68e-59 198.0 COG0477@1|root,COG2814@2|Bacteria,1QUTR@1224|Proteobacteria,2TW7A@28211|Alphaproteobacteria,2JZ6R@204441|Rhodospirillales 204441|Rhodospirillales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1497458_1 1121033.AUCF01000026_gene2913 7.88e-128 373.0 COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,2JR4P@204441|Rhodospirillales 204441|Rhodospirillales H Ketopantoate reductase PanE/ApbA C terminal - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_87832_1 247490.KSU1_D1045 1.21e-51 182.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein - - - - - - - - - - - - SPASM k59_341704_1 744872.Spica_1065 2.75e-08 56.2 COG0841@1|root,COG0841@2|Bacteria,2J5U5@203691|Spirochaetes 203691|Spirochaetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_341704_2 1410631.JHWZ01000003_gene1532 3.02e-35 137.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,27IJT@186928|unclassified Lachnospiraceae 186801|Clostridia V AcrB/AcrD/AcrF family czcA - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1019493_1 1121413.JMKT01000008_gene1419 5.08e-33 131.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WJ2A@28221|Deltaproteobacteria,2MG2S@213115|Desulfovibrionales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_662998_1 349521.HCH_02542 9.68e-78 258.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1XHB4@135619|Oceanospirillales 135619|Oceanospirillales E Methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_601834_3 1123257.AUFV01000002_gene2406 1.6e-29 108.0 COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,1SBJ7@1236|Gammaproteobacteria,1X7WB@135614|Xanthomonadales 135614|Xanthomonadales C Succinate dehydrogenase sdhC - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_1329161_1 1121430.JMLG01000026_gene27 4.79e-45 159.0 COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,260T7@186807|Peptococcaceae 186801|Clostridia LU DNA protecting protein DprA dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_134611_1 1229909.NSED_09580 2.6e-27 103.0 COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota 651137|Thaumarchaeota L protein conserved in archaea - - - ko:K09723 - - - - ko00000,ko03032 - - - - k59_134611_2 1131266.ARWQ01000001_gene1359 1.38e-24 95.9 arCOG08809@1|root,arCOG08809@2157|Archaea,41TAB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_601846_1 717774.Marme_3529 3.34e-104 317.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XI3Y@135619|Oceanospirillales 135619|Oceanospirillales T Response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes glnG - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_549032_2 314285.KT71_03057 4.93e-42 148.0 COG2159@1|root,COG2159@2|Bacteria,1QPUF@1224|Proteobacteria,1SJMG@1236|Gammaproteobacteria,1J85C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S amidohydrolase - - - - - - - - - - - - - k59_1650790_1 330214.NIDE4163 6.21e-13 62.8 COG0828@1|root,COG0828@2|Bacteria 2|Bacteria J Belongs to the bacterial ribosomal protein bS21 family rpsU GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 k59_1650790_2 330214.NIDE4162 1.69e-117 340.0 COG0177@1|root,COG0177@2|Bacteria,3J0K6@40117|Nitrospirae 2|Bacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006289,GO:0006296,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.2,4.2.99.18 ko:K01142,ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_820098_1 522772.Dacet_2451 8.91e-90 282.0 COG0342@1|root,COG0342@2|Bacteria,2GFA5@200930|Deferribacteres 200930|Deferribacteres U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_1072975_1 290397.Adeh_2253 2.65e-135 405.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YU@28221|Deltaproteobacteria,2YYW6@29|Myxococcales 28221|Deltaproteobacteria K ATPase associated with various cellular activities, AAA_5 - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,PAS_9,Sigma54_activat k59_549047_1 1090320.KB900605_gene1183 2.91e-24 107.0 COG0793@1|root,COG0793@2|Bacteria,1MUA3@1224|Proteobacteria,2U1FI@28211|Alphaproteobacteria,2K0WR@204457|Sphingomonadales 204457|Sphingomonadales M Peptidase family S41 - - - - - - - - - - - - Peptidase_S41 k59_1019532_1 1085623.GNIT_3500 7.28e-21 97.1 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPES@1236|Gammaproteobacteria,464G8@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains yheS GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_1233837_1 331869.BAL199_17498 4.23e-53 177.0 COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,2TUF8@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Fatty acid desaturase des - 1.14.19.23,1.14.19.45 ko:K10255 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_1290045_1 13689.BV96_04691 2.43e-71 224.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2K2F6@204457|Sphingomonadales 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve,rve_3 k59_830346_2 616991.JPOO01000001_gene4214 2.95e-22 100.0 COG0367@1|root,COG0367@2|Bacteria,4NFQ3@976|Bacteroidetes,1HXV0@117743|Flavobacteriia,23GB6@178469|Arenibacter 976|Bacteroidetes E Aluminium induced protein - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1026543_1 236097.ADG881_2072 4.45e-39 143.0 COG0679@1|root,COG0679@2|Bacteria,1P2SH@1224|Proteobacteria,1RQGC@1236|Gammaproteobacteria,1XRNP@135619|Oceanospirillales 135619|Oceanospirillales S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_1179514_1 404589.Anae109_0518 1.97e-76 253.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2WJ51@28221|Deltaproteobacteria,2YTV0@29|Myxococcales 28221|Deltaproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_1300202_1 338963.Pcar_1555 2.37e-60 214.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,43RX8@69541|Desulfuromonadales 28221|Deltaproteobacteria J Translation-initiation factor 2 infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_401154_1 207954.MED92_06533 2.34e-18 92.4 COG0501@1|root,COG0501@2|Bacteria,1QAMJ@1224|Proteobacteria,1S05I@1236|Gammaproteobacteria,1XHVB@135619|Oceanospirillales 135619|Oceanospirillales O Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_1542026_1 1158338.JNLJ01000001_gene940 8.97e-08 58.9 COG3391@1|root,COG3391@2|Bacteria,2G4DB@200783|Aquificae 200783|Aquificae S NHL repeat containing protein - - - - - - - - - - - - DUF5128,NHL k59_144146_1 211165.AJLN01000085_gene1672 1.79e-50 169.0 COG0605@1|root,COG0605@2|Bacteria,1G0VH@1117|Cyanobacteria,1JJAI@1189|Stigonemataceae 1117|Cyanobacteria P Iron/manganese superoxide dismutases, alpha-hairpin domain - - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_609221_1 449447.MAE_23240 6.02e-46 153.0 COG2954@1|root,COG2954@2|Bacteria,1G5NQ@1117|Cyanobacteria 1117|Cyanobacteria S protein conserved in bacteria - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CYTH k59_609221_2 1249627.D779_1642 2.33e-23 98.6 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria,1WW96@135613|Chromatiales 135613|Chromatiales M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - - ko:K02474 ko00520,map00520 - R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1601535_1 436308.Nmar_1004 7.66e-73 235.0 COG0405@1|root,arCOG04053@2157|Archaea 2157|Archaea E gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1392174_1 323261.Noc_2717 9.41e-167 488.0 COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RPSW@1236|Gammaproteobacteria,1WVZE@135613|Chromatiales 135613|Chromatiales G D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase - - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_1301910_1 1229909.NSED_01250 5.6e-73 231.0 COG0470@1|root,arCOG00470@2157|Archaea,41S9F@651137|Thaumarchaeota 651137|Thaumarchaeota L ATPase family associated with various cellular activities (AAA) - - - ko:K04800 ko03030,map03030 - - - ko00000,ko00001,ko03032 - - - AAA k59_871399_1 1192034.CAP_7925 0.000319 43.9 COG1413@1|root,COG3119@1|root,COG1413@2|Bacteria,COG3119@2|Bacteria,1MWY7@1224|Proteobacteria,42V1G@68525|delta/epsilon subdivisions,2WRCZ@28221|Deltaproteobacteria,2YWCA@29|Myxococcales 28221|Deltaproteobacteria P Sulfatase - - - - - - - - - - - - Sulfatase k59_871399_2 329726.AM1_2202 7.02e-11 68.2 COG1835@1|root,COG1835@2|Bacteria 2|Bacteria I transferase activity, transferring acyl groups other than amino-acyl groups - - - - - - - - - - - - Acyl_transf_3 k59_1392180_1 472759.Nhal_1699 2.25e-100 297.0 COG1611@1|root,COG3350@1|root,COG1611@2|Bacteria,COG3350@2|Bacteria,1R8EU@1224|Proteobacteria,1SKDD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S YHS domain - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - YHS k59_244818_1 1048339.KB913029_gene4346 2.07e-34 136.0 COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,4ERGD@85013|Frankiales 201174|Actinobacteria G Belongs to the transketolase family tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_716862_1 247633.GP2143_15321 3.3e-50 165.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,1RP1N@1236|Gammaproteobacteria,1J5SA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_674956_1 880070.Cycma_4731 9.23e-21 94.0 COG2203@1|root,COG3290@1|root,COG4251@1|root,COG2203@2|Bacteria,COG3290@2|Bacteria,COG4251@2|Bacteria,4NFC3@976|Bacteroidetes,47KWE@768503|Cytophagia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9 k59_1083315_1 1229909.NSED_08190 8.42e-81 256.0 COG0072@1|root,arCOG00412@2157|Archaea,41S8M@651137|Thaumarchaeota 651137|Thaumarchaeota J phenylalanyl-tRNA synthetase, beta subunit - - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5 k59_1135330_2 1121896.JMLU01000004_gene2681 7.01e-06 51.6 COG4485@1|root,COG4485@2|Bacteria,4NEE5@976|Bacteroidetes,1HX3C@117743|Flavobacteriia,2NU9W@237|Flavobacterium 976|Bacteroidetes S membrane - - - - - - - - - - - - YfhO k59_1509519_1 526222.Desal_2406 2.03e-18 77.8 COG1826@1|root,COG1826@2|Bacteria,1NGDP@1224|Proteobacteria,42V5P@68525|delta/epsilon subdivisions,2WRM0@28221|Deltaproteobacteria,2MD43@213115|Desulfovibrionales 28221|Deltaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_1509519_2 1449353.JQMQ01000005_gene1103 4.04e-11 63.9 COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria,2NGNK@228398|Streptacidiphilus 201174|Actinobacteria G Phosphoglucomutase/phosphomannomutase, C-terminal domain manB - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1336773_1 999141.GME_04272 1.05e-25 99.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1XJ9H@135619|Oceanospirillales 135619|Oceanospirillales F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_1336773_2 867903.ThesuDRAFT_01205 7.21e-38 137.0 COG0321@1|root,COG0321@2|Bacteria,1V44P@1239|Firmicutes,24GE9@186801|Clostridia 186801|Clostridia H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB - 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_516085_1 1209072.ALBT01000008_gene2927 8.29e-09 53.5 COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,1S91G@1236|Gammaproteobacteria,1FHNG@10|Cellvibrio 1236|Gammaproteobacteria D BolA-like protein bolA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - ko:K05527 - - - - ko00000,ko03000 - - - BolA k59_516085_2 570967.JMLV01000006_gene209 3.75e-56 188.0 COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2TRA4@28211|Alphaproteobacteria,2JPPF@204441|Rhodospirillales 204441|Rhodospirillales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_457298_1 2074.JNYD01000006_gene1925 2.77e-15 77.0 COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_457298_2 1232437.KL662036_gene2717 5.95e-63 211.0 COG1028@1|root,COG3427@1|root,COG1028@2|Bacteria,COG3427@2|Bacteria,1P9R4@1224|Proteobacteria,42TE9@68525|delta/epsilon subdivisions,2WPGF@28221|Deltaproteobacteria,2MIUD@213118|Desulfobacterales 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - Polyketide_cyc2,adh_short k59_1135346_1 999419.HMPREF1077_00704 1.23e-09 59.7 COG0653@1|root,COG0653@2|Bacteria,4NF7C@976|Bacteroidetes,2FMVF@200643|Bacteroidia,22WWV@171551|Porphyromonadaceae 976|Bacteroidetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1135346_2 330214.NIDE0344 1.25e-32 123.0 COG0714@1|root,COG0714@2|Bacteria,3J0WQ@40117|Nitrospirae 40117|Nitrospirae S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1180565_1 247634.GPB2148_1369 1.99e-44 161.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1J4CG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034203,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576 - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - iECO103_1326.ECO103_1114 MVIN k59_716895_1 930169.B5T_02649 2.46e-10 64.7 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1XHZY@135619|Oceanospirillales 135619|Oceanospirillales U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltP - - - - - - - - - - - SDF k59_1135356_1 1122929.KB908215_gene1108 1.1e-09 61.6 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2TT42@28211|Alphaproteobacteria 28211|Alphaproteobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_766375_1 589865.DaAHT2_2030 1.87e-09 62.8 COG5421@1|root,COG5421@2|Bacteria,1R7NE@1224|Proteobacteria,42M25@68525|delta/epsilon subdivisions,2WKHV@28221|Deltaproteobacteria,2MJVY@213118|Desulfobacterales 28221|Deltaproteobacteria L IMG reference gene - - - - - - - - - - - - DDE_Tnp_1 k59_299766_1 1122135.KB893138_gene1124 1.97e-44 161.0 COG1178@1|root,COG1178@2|Bacteria,1MXZZ@1224|Proteobacteria,2TT7F@28211|Alphaproteobacteria 28211|Alphaproteobacteria P ABC-type Fe3 transport system permease component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_1302002_1 369723.Strop_3120 8.04e-61 204.0 COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria,4DBSR@85008|Micromonosporales 201174|Actinobacteria C PFAM FAD linked oxidase domain protein agpS - 2.5.1.26 ko:K00803 ko00565,ko01100,ko04146,map00565,map01100,map04146 - R04311 RC00020,RC02886 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1601575_1 1089552.KI911559_gene1443 8.36e-137 401.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria,2JPVB@204441|Rhodospirillales 204441|Rhodospirillales M Belongs to the UDP-glucose GDP-mannose dehydrogenase family rkpK - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_675016_1 690585.JNNU01000002_gene4675 9.8e-21 98.2 COG1748@1|root,COG1748@2|Bacteria,1P35E@1224|Proteobacteria,2TSYM@28211|Alphaproteobacteria,4BBHJ@82115|Rhizobiaceae 28211|Alphaproteobacteria E Domain of unknown function (DUF4166) - - - - - - - - - - - - DUF4166,Sacchrp_dh_NADP k59_975441_2 472759.Nhal_0548 5.06e-32 124.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_457313_1 1502724.FF80_00668 5.92e-43 145.0 COG1522@1|root,COG1522@2|Bacteria,1RDB3@1224|Proteobacteria,2U580@28211|Alphaproteobacteria,3N6RN@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria K helix_turn_helix ASNC type - - - ko:K05800 - - - - ko00000,ko03000 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_457313_2 452662.SJA_C2-04250 2.73e-19 81.3 2C91B@1|root,33D4Z@2|Bacteria,1NGZZ@1224|Proteobacteria,2UK78@28211|Alphaproteobacteria,2KDAR@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_766386_1 1333998.M2A_0917 1.62e-43 157.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TRWB@28211|Alphaproteobacteria,4BP6Q@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia pabB - 2.6.1.85,4.1.3.27 ko:K01657,ko:K01665 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_675026_1 330214.NIDE4047 9.94e-34 119.0 COG0776@1|root,COG0776@2|Bacteria 2|Bacteria L regulation of translation hup - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_1135372_1 395493.BegalDRAFT_2300 2.36e-96 315.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,45ZWV@72273|Thiotrichales 72273|Thiotrichales E Glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1027854_1 105559.Nwat_0536 2.07e-56 176.0 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria,1WYTD@135613|Chromatiales 135613|Chromatiales O Belongs to the thioredoxin family - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_1083369_1 1382356.JQMP01000003_gene1573 1.04e-68 224.0 COG0028@1|root,COG0028@2|Bacteria,2G810@200795|Chloroflexi,27XX3@189775|Thermomicrobia 189775|Thermomicrobia EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_402290_1 1123073.KB899245_gene181 7.74e-38 144.0 28HYC@1|root,2Z83T@2|Bacteria,1QEBM@1224|Proteobacteria,1RRCK@1236|Gammaproteobacteria,1X5W1@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_402290_2 506534.Rhein_3451 2.74e-06 48.1 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1RS4F@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane yjdF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K08984 - - - - ko00000 - - - DUF2238 k59_1542125_1 935948.KE386495_gene1805 1.33e-05 52.8 COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,249F4@186801|Clostridia,42F62@68295|Thermoanaerobacterales 186801|Clostridia D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1509601_1 395493.BegalDRAFT_1391 5.49e-21 88.6 COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,1S425@1236|Gammaproteobacteria,4610J@72273|Thiotrichales 72273|Thiotrichales O Belongs to the glutathione peroxidase family - - - - - - - - - - - - GSHPx k59_1662903_1 391625.PPSIR1_01774 2.67e-90 288.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42QKW@68525|delta/epsilon subdivisions,2WKH1@28221|Deltaproteobacteria,2YWTQ@29|Myxococcales 1224|Proteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1083380_1 472175.EL18_02726 2.49e-11 60.1 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2UCCR@28211|Alphaproteobacteria,43KHX@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_1509607_1 238854.Q5GQC8_BPSYP 8.97e-42 152.0 4QGTP@10239|Viruses,4R0J6@35237|dsDNA viruses no RNA stage,4QT4W@28883|Caudovirales,4QI00@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_98493_1 1523503.JPMY01000028_gene319 2.16e-48 172.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria 1236|Gammaproteobacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_98493_2 1517416.IDAT_06870 8.84e-21 90.9 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,2QFDD@267893|Idiomarinaceae 1236|Gammaproteobacteria J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_516175_1 330214.NIDE4122 5.43e-48 171.0 COG0249@1|root,COG0249@2|Bacteria,3J0CE@40117|Nitrospirae 40117|Nitrospirae L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_244907_1 1095750.HMPREF9970_3003 7.54e-40 145.0 COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,247KW@186801|Clostridia,1HUYS@1164882|Lachnoanaerobaculum 186801|Clostridia I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_244907_2 316067.Geob_3482 1.6e-28 108.0 COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,42SCB@68525|delta/epsilon subdivisions,2WPEA@28221|Deltaproteobacteria,43UQ7@69541|Desulfuromonadales 28221|Deltaproteobacteria E TIGRFAM D,D-heptose 1,7-bisphosphate phosphatase gmhB - 3.1.3.82,3.1.3.83 ko:K03273 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_like k59_871487_1 866536.Belba_0812 2.93e-124 385.0 COG0653@1|root,COG0653@2|Bacteria,4NF7C@976|Bacteroidetes,47JTE@768503|Cytophagia 976|Bacteroidetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1392257_1 768671.ThimaDRAFT_1319 1.89e-81 253.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1WX16@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1509628_1 1499967.BAYZ01000184_gene4587 1.19e-09 58.5 COG4122@1|root,COG4122@2|Bacteria,2NQFB@2323|unclassified Bacteria 2|Bacteria S Pup-ligase protein dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 ko:K20814 - - - - ko00000,ko01000,ko03051 - - - Pup_ligase k59_1509628_2 1445613.JALM01000123_gene1408 3.05e-46 166.0 COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,4DZ1H@85010|Pseudonocardiales 201174|Actinobacteria O ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis arc GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369 - ko:K13527 ko03050,map03050 M00342 - - ko00000,ko00001,ko00002,ko03051 - - - AAA,Prot_ATP_ID_OB k59_1509629_1 330214.NIDE2073 1.06e-88 280.0 COG1389@1|root,COG1389@2|Bacteria 2|Bacteria L DNA topoisomerase II activity top6B - 5.99.1.3 ko:K03167 - - - - ko00000,ko01000,ko03032 - - - HATPase_c,HATPase_c_3,Topo-VIb_trans k59_1180621_1 1499967.BAYZ01000105_gene3517 5.38e-05 50.4 COG2755@1|root,COG2755@2|Bacteria,2NR42@2323|unclassified Bacteria 2|Bacteria E lipolytic protein G-D-S-L family - - 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - ChitinaseA_N,Lipase_GDSL_2 k59_144225_1 1419583.V466_18450 1.57e-19 92.8 COG4191@1|root,COG4191@2|Bacteria,1R8JK@1224|Proteobacteria,1SC56@1236|Gammaproteobacteria,1YSYB@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_1180626_1 1229909.NSED_04900 6.07e-65 204.0 COG3638@1|root,arCOG00206@2157|Archaea,41SY4@651137|Thaumarchaeota 651137|Thaumarchaeota E ABC transporter - - 3.6.3.28 ko:K02041 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.9 - - ABC_tran k59_1180626_2 436308.Nmar_0873 8.3e-38 134.0 COG3639@1|root,arCOG00173@2157|Archaea,41SZI@651137|Thaumarchaeota 651137|Thaumarchaeota P phosphonate ABC transporter, inner membrane subunit - - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 k59_675097_1 243233.MCA3089 1.22e-68 226.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1XENC@135618|Methylococcales 135618|Methylococcales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_516214_2 1547437.LL06_01395 9.66e-56 181.0 COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,2TSAI@28211|Alphaproteobacteria,43K2W@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O Cytochrome c biogenesis protein ccdA - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD k59_1662956_1 887327.HMPREF0476_0273 4.91e-34 124.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2VH29@28216|Betaproteobacteria,2KPFV@206351|Neisseriales 206351|Neisseriales S Psort location Cytoplasmic, score 9.12 lptB - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_1662956_2 1209072.ALBT01000047_gene454 9.21e-14 70.9 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1FGTN@10|Cellvibrio 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_1083424_1 1121889.AUDM01000003_gene2208 7.72e-110 332.0 COG3550@1|root,COG3550@2|Bacteria,4NFYY@976|Bacteroidetes,1HXAI@117743|Flavobacteriia,2NVFA@237|Flavobacterium 976|Bacteroidetes S Pfam:HipA_N - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_1450813_1 1123070.KB899251_gene714 4.07e-15 85.5 COG0421@1|root,COG0421@2|Bacteria 2|Bacteria E spermidine synthase activity - - - - - - - - - - - - Spermine_synth k59_609366_1 1996.JOFO01000027_gene6624 7.84e-56 192.0 COG0128@1|root,COG0128@2|Bacteria,2GJKX@201174|Actinobacteria,4ENKI@85012|Streptosporangiales 201174|Actinobacteria E EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) - GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_832270_1 1335757.SPICUR_04005 1.42e-11 67.8 COG3963@1|root,COG3963@2|Bacteria,1RATY@1224|Proteobacteria,1S1YM@1236|Gammaproteobacteria,1X211@135613|Chromatiales 135613|Chromatiales I methyltransferase - - - - - - - - - - - - - k59_1392292_1 313606.M23134_06879 2e-93 283.0 COG0564@1|root,COG0564@2|Bacteria,4NEV3@976|Bacteroidetes,47MPT@768503|Cytophagia 976|Bacteroidetes J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_557887_1 1461693.ATO10_09938 6.49e-105 312.0 COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases lldD1 GO:0002218,GO:0002253,GO:0002376,GO:0002682,GO:0002684,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006950,GO:0006952,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009605,GO:0009607,GO:0009617,GO:0009987,GO:0010204,GO:0016999,GO:0017000,GO:0017144,GO:0023052,GO:0031347,GO:0031349,GO:0042579,GO:0042742,GO:0042743,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0045088,GO:0045089,GO:0048518,GO:0048583,GO:0048584,GO:0050665,GO:0050776,GO:0050778,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0072593,GO:0080134,GO:0098542,GO:1903409 1.1.2.3 ko:K00101 ko00620,ko01100,map00620,map01100 - R00196 RC00044 ko00000,ko00001,ko01000 - - - FMN_dh k59_402363_2 40571.JOEA01000017_gene371 8.65e-17 82.0 COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4DXRB@85010|Pseudonocardiales 201174|Actinobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - HHH_5,IMS,IMS_C,IMS_HHH k59_1509692_1 450851.PHZ_c1441 1.37e-47 158.0 COG1247@1|root,COG1247@2|Bacteria,1PP4R@1224|Proteobacteria,2UCHD@28211|Alphaproteobacteria,2KINR@204458|Caulobacterales 204458|Caulobacterales M Acetyltransferase (GNAT) domain - - 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 - R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 - - - Acetyltransf_4 k59_832300_1 1121935.AQXX01000106_gene526 2e-21 94.4 COG3471@1|root,COG3471@2|Bacteria,1MZA2@1224|Proteobacteria,1S793@1236|Gammaproteobacteria 1236|Gammaproteobacteria S periplasmic secreted protein Z012_10940 - - - - - - - - - - - SIMPL k59_776239_1 1114964.L485_04690 2.22e-30 114.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2U5MT@28211|Alphaproteobacteria,2K417@204457|Sphingomonadales 204457|Sphingomonadales O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_1553755_1 926550.CLDAP_08960 5.11e-81 259.0 COG0490@1|root,COG0569@1|root,COG1226@1|root,COG0490@2|Bacteria,COG0569@2|Bacteria,COG1226@2|Bacteria 2|Bacteria P (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - - - - - - - - - - Ion_trans_2,TrkA_C,TrkA_N k59_1094636_1 443218.AS9A_4297 1.31e-65 216.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,233DK@1762|Mycobacteriaceae 201174|Actinobacteria C cytochrome p450 cyp123A3 GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616,GO:1902652 - - - - - - - - - - p450 k59_621387_1 765912.Thimo_1923 1.55e-39 133.0 COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria,1WYKM@135613|Chromatiales 135613|Chromatiales S RNA-binding protein - - - - - - - - - - - - RRM_1 k59_414251_1 926550.CLDAP_33590 5.65e-51 177.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2G6DU@200795|Chloroflexi 200795|Chloroflexi S PFAM molybdopterin binding domain - - - - - - - - - - - - CinA,MoCF_biosynth k59_1148102_1 1493507.A0A0E3ICE3_9CAUD 3.63e-07 63.2 4QBUC@10239|Viruses,4QVRG@35237|dsDNA viruses no RNA stage,4QQGQ@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_255110_1 1163409.UUA_12545 5.88e-49 163.0 COG0431@1|root,COG0431@2|Bacteria,1RH7F@1224|Proteobacteria,1T04E@1236|Gammaproteobacteria,1XCYS@135614|Xanthomonadales 135614|Xanthomonadales S NAD(P)H-dependent FMN reductase - - - - - - - - - - - - FMN_red k59_255110_2 1379270.AUXF01000005_gene646 1.2e-13 70.9 COG2070@1|root,COG2070@2|Bacteria,1ZUN8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Nitronate monooxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_1461364_2 930169.B5T_01143 2.96e-16 76.6 COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,1S24F@1236|Gammaproteobacteria,1XJAQ@135619|Oceanospirillales 135619|Oceanospirillales S Carboxylesterase - - - ko:K06999 - - - - ko00000 - - - Abhydrolase_2 k59_1461371_1 396588.Tgr7_1439 4.96e-213 600.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1WWHB@135613|Chromatiales 135613|Chromatiales E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_1461371_2 314285.KT71_18172 7.83e-35 129.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RQBM@1236|Gammaproteobacteria,1J57D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Aminotransferase class I and II yfdZ GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - ko:K14261 - - - - ko00000,ko01000,ko01007 - - iEcSMS35_1347.EcSMS35_2531,iSBO_1134.SBO_2405 Aminotran_1_2 k59_1461372_1 76114.ebA2099 1.21e-62 211.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2VZ75@28216|Betaproteobacteria,2KXX2@206389|Rhodocyclales 206389|Rhodocyclales C NADH:flavin oxidoreductase / NADH oxidase family - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 k59_362869_1 1256908.HMPREF0373_00850 9.17e-14 76.3 COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,25VZS@186806|Eubacteriaceae 186801|Clostridia V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_468598_1 485915.Dret_0844 2.94e-35 137.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,42MBR@68525|delta/epsilon subdivisions,2WJ0Z@28221|Deltaproteobacteria,2M953@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM peptidase M48 Ste24p - - - - - - - - - - - iAF987.Gmet_1238 Peptidase_M48,TPR_14,TPR_16,TPR_19 k59_727167_1 196490.AUEZ01000137_gene5838 9.89e-29 115.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_414284_1 937774.TEQUI_0375 2.35e-36 141.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,3T2UE@506|Alcaligenaceae 28216|Betaproteobacteria P Belongs to the ABC transporter superfamily gsiA - - ko:K02031,ko:K02032,ko:K13892 ko02010,ko02024,map02010,map02024 M00239,M00348 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.11 - - ABC_tran,oligo_HPY k59_414287_1 443144.GM21_4144 4.13e-33 122.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,42M0X@68525|delta/epsilon subdivisions,2WK4D@28221|Deltaproteobacteria,43SVU@69541|Desulfuromonadales 28221|Deltaproteobacteria EM Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_414287_2 614083.AWQR01000021_gene236 2.33e-11 64.3 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria,4A9QE@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_621421_1 385682.AFSL01000074_gene1216 6.69e-52 186.0 COG0155@1|root,COG0155@2|Bacteria,4NENW@976|Bacteroidetes,2FRKX@200643|Bacteroidia,3XJJ4@558415|Marinilabiliaceae 976|Bacteroidetes P Nitrite and sulphite reductase 4Fe-4S domain cysI - 1.7.7.1,1.8.1.2 ko:K00366,ko:K00381 ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120 M00176,M00531 R00790,R00858 RC00065,RC00176 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_776281_1 102232.GLO73106DRAFT_00027900 1.23e-20 88.6 COG1351@1|root,COG1351@2|Bacteria 2|Bacteria F thymidylate synthase (FAD) activity thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_776281_2 272951.rsib_orf46 1.87e-09 60.1 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,2TS3X@28211|Alphaproteobacteria,47ETF@766|Rickettsiales 766|Rickettsiales F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdB - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_311148_1 240292.Ava_3046 3.89e-93 302.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1G2E2@1117|Cyanobacteria,1HS11@1161|Nostocales 1117|Cyanobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_468621_1 272123.Anacy_0890 1.12e-42 158.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1GMZK@1117|Cyanobacteria,1HRMB@1161|Nostocales 1117|Cyanobacteria T PFAM Adenylate and Guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_938292_1 1380387.JADM01000023_gene1842 1.84e-96 306.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1XH2S@135619|Oceanospirillales 135619|Oceanospirillales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_154952_1 1429046.RR21198_2201 2.24e-65 211.0 COG1545@1|root,COG1545@2|Bacteria,2GM2A@201174|Actinobacteria,4FX49@85025|Nocardiaceae 201174|Actinobacteria S Rubredoxin-like zinc ribbon domain (DUF35_N) - - - - - - - - - - - - DUF35_N,MaoC_dehydrat_N,OB_aCoA_assoc k59_154952_2 762376.AXYL_04897 1.44e-09 62.0 COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2VMYJ@28216|Betaproteobacteria,3T5E5@506|Alcaligenaceae 28216|Betaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_154954_1 472759.Nhal_0691 9.24e-117 346.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1WWTN@135613|Chromatiales 135613|Chromatiales E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5,SufE k59_985117_1 861299.J421_2807 9.18e-91 280.0 COG0104@1|root,COG0104@2|Bacteria,1ZSNV@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_881729_1 445686.E3SLI3_9CAUD 7.73e-06 45.4 4QHIS@10239|Viruses,4QYTX@35237|dsDNA viruses no RNA stage,4QT66@28883|Caudovirales,4QK9P@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_881729_2 1493511.A0A0E3HL07_9CAUD 1.05e-63 204.0 4QCVH@10239|Viruses,4QRHW@28883|Caudovirales,4QJX6@10662|Myoviridae 10662|Myoviridae S Glycosyltransferase family 25 (LPS biosynthesis protein) - - - - - - - - - - - - - k59_414338_1 1245471.PCA10_53610 1.83e-10 68.2 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,1YDAP@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M AsmA family asmA - - ko:K07289 - - - - ko00000 - - - AsmA k59_1461462_1 326297.Sama_3024 2.3e-13 73.2 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,2Q94S@267890|Shewanellaceae 1236|Gammaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_1461462_2 1042377.AFPJ01000032_gene2792 4.33e-10 60.5 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,464H8@72275|Alteromonadaceae 1236|Gammaproteobacteria O HflC and HflK could encode or regulate a protease hflK GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564 - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_1347501_1 330214.NIDE1873 1.2e-30 125.0 COG2982@1|root,COG2982@2|Bacteria 2|Bacteria M Protein involved in outer membrane biogenesis - - - - - - - - - - - - DUF748,OmpA k59_568151_2 1121380.JNIW01000035_gene1398 7.28e-32 123.0 COG1600@1|root,COG1600@2|Bacteria,1WJ6B@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C TIGRFAM iron-sulfur cluster binding protein - - - - - - - - - - - - DUF1730,Fer4_16,HEAT,HEAT_2 k59_1191313_1 1205683.CAKR01000009_gene1479 5.27e-35 128.0 COG0500@1|root,COG2226@2|Bacteria,1MV4M@1224|Proteobacteria,1RMWY@1236|Gammaproteobacteria,41F5F@629|Yersinia 1236|Gammaproteobacteria Q Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM) cmoA GO:0002097,GO:0002098,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 - ko:K15256 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_25 k59_1038116_1 1158762.KB898044_gene371 0.00092 42.4 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1WXKR@135613|Chromatiales 135613|Chromatiales NU Pilus assembly protein PilO - - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_1038116_2 1049564.TevJSym_bb00170 2.13e-24 98.6 COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,1S6VJ@1236|Gammaproteobacteria,1J6N8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG3168 Tfp pilus assembly protein PilP pilP - - ko:K02665 - - - - ko00000,ko02035,ko02044 - - - PilP k59_1402833_1 1121875.KB907547_gene3471 1.55e-58 197.0 2C20F@1|root,32R9J@2|Bacteria,4P0SP@976|Bacteroidetes 976|Bacteroidetes S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - - - - - - - - - - Peptidase_C92 k59_468666_1 443143.GM18_2280 6.21e-49 177.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,43TNR@69541|Desulfuromonadales 28221|Deltaproteobacteria T GGDEF domain containing protein - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS,PAS_3,PAS_9,Response_reg k59_311207_1 396588.Tgr7_0061 5.05e-100 307.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1WWEC@135613|Chromatiales 135613|Chromatiales S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_1347522_1 1121459.AQXE01000015_gene328 1.68e-15 77.4 COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria,2M7RB@213115|Desulfovibrionales 28221|Deltaproteobacteria GM NAD-dependent epimerase dehydratase - - - - - - - - - - - - DUF2867,NAD_binding_10 k59_1347522_2 660470.Theba_2014 2.39e-29 114.0 COG4294@1|root,COG4294@2|Bacteria 2|Bacteria L response to UV uvsE - - ko:K13281 - - - - ko00000,ko01000 - - - DUF1722,UvdE k59_985162_1 1521187.JPIM01000083_gene3847 1.06e-94 303.0 COG1048@1|root,COG1048@2|Bacteria,2G5NG@200795|Chloroflexi,374T1@32061|Chloroflexia 32061|Chloroflexia C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1347526_1 234267.Acid_4992 4.82e-22 102.0 COG1538@1|root,COG1538@2|Bacteria,3Y2NZ@57723|Acidobacteria 57723|Acidobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1094763_1 338966.Ppro_0744 1.1e-27 110.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,42RVM@68525|delta/epsilon subdivisions,2WQIY@28221|Deltaproteobacteria,43UNV@69541|Desulfuromonadales 28221|Deltaproteobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_985168_1 525897.Dbac_1915 8.79e-97 313.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WJ2A@28221|Deltaproteobacteria,2MG2S@213115|Desulfovibrionales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_727249_1 1280948.HY36_13155 3.66e-34 128.0 COG0346@1|root,COG0346@2|Bacteria,1MXZ4@1224|Proteobacteria,2TUBZ@28211|Alphaproteobacteria,43XQV@69657|Hyphomonadaceae 28211|Alphaproteobacteria E COG0346 Lactoylglutathione lyase and related lyases MA20_16915 - - - - - - - - - - - Glyoxalase,Glyoxalase_3,Glyoxalase_4 k59_1148237_1 1122614.JHZF01000013_gene4193 1.52e-132 380.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,2PD3Q@252301|Oceanicola 28211|Alphaproteobacteria E ABC transporter, ATP-binding protein bztD - 3.6.3.21 ko:K02028,ko:K09972 ko02010,map02010 M00232,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - ABC_tran k59_1461499_1 1208323.B30_06126 2.31e-16 84.7 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2TR8K@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG2230 Cyclopropane fatty acid synthase and related methyltransferases cfa GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0008825,GO:0009987,GO:0016740,GO:0016741,GO:0030258,GO:0032259,GO:0044237,GO:0044238,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_1402864_1 1123242.JH636434_gene3663 1.41e-54 181.0 COG0821@1|root,COG0821@2|Bacteria,2IXN9@203682|Planctomycetes 203682|Planctomycetes I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_1461500_1 502025.Hoch_2050 4.01e-44 156.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,42MA8@68525|delta/epsilon subdivisions,2WIXR@28221|Deltaproteobacteria,2YUA9@29|Myxococcales 28221|Deltaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_1461500_2 502025.Hoch_2049 2.9e-39 140.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,42PS4@68525|delta/epsilon subdivisions,2WM4V@28221|Deltaproteobacteria,2YUI4@29|Myxococcales 28221|Deltaproteobacteria S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_1148239_3 908338.HMPREF9286_0118 8.33e-26 103.0 COG1032@1|root,COG1032@2|Bacteria,1TQF0@1239|Firmicutes,24A0T@186801|Clostridia,22G86@1570339|Peptoniphilaceae 186801|Clostridia C Radical SAM domain protein - - - - - - - - - - - - Radical_SAM k59_362982_1 713587.THITH_15650 1.23e-109 325.0 COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,1WWXZ@135613|Chromatiales 135613|Chromatiales H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_1404733_1 909663.KI867150_gene1831 4.21e-43 151.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42S1J@68525|delta/epsilon subdivisions,2WP2S@28221|Deltaproteobacteria,2MRQY@213462|Syntrophobacterales 28221|Deltaproteobacteria I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family plsC - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_1555571_1 95619.PM1_0228840 1.01e-30 121.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria 1236|Gammaproteobacteria C protein containing LysM domain lysM - - - - - - - - - - - LysM k59_1193213_1 1303518.CCALI_01862 3.19e-17 89.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria 2|Bacteria E serine-type peptidase activity - - 3.4.14.5 ko:K01278,ko:K06889 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - PD40,Peptidase_S9 k59_416010_1 1132855.KB913035_gene1268 4.08e-72 231.0 COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2VHMY@28216|Betaproteobacteria,2KMAY@206350|Nitrosomonadales 206350|Nitrosomonadales L Belongs to the methyltransferase superfamily - - - ko:K07444 - - - - ko00000,ko01000 - - - THUMP,UPF0020 k59_1555582_1 1321779.HMPREF1984_02176 1.12e-18 90.1 COG2211@1|root,COG2211@2|Bacteria,3783P@32066|Fusobacteria 32066|Fusobacteria G Psort location CytoplasmicMembrane, score 10.00 - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_1404751_1 1232437.KL662020_gene705 7.57e-86 268.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_312887_1 1163617.SCD_n02628 2.09e-53 183.0 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,2VMDE@28216|Betaproteobacteria 28216|Betaproteobacteria N transport system - - - - - - - - - - - - ABC_transp_aux k59_1193230_1 324925.Ppha_2788 1.38e-56 179.0 COG1970@1|root,COG1970@2|Bacteria,1FF5D@1090|Chlorobi 1090|Chlorobi C Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL - - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL k59_777558_1 690850.Desaf_0986 6.28e-25 102.0 COG1653@1|root,COG1653@2|Bacteria,1MVMW@1224|Proteobacteria,42N79@68525|delta/epsilon subdivisions,2WM0N@28221|Deltaproteobacteria,2MAEC@213115|Desulfovibrionales 28221|Deltaproteobacteria G Bacterial extracellular solute-binding protein - - - ko:K02027,ko:K05813 ko02010,map02010 M00198,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.3 - - SBP_bac_8 k59_728492_1 1318628.MARLIPOL_15712 1.67e-09 57.8 COG1664@1|root,COG1664@2|Bacteria,1PDPX@1224|Proteobacteria,1S9XY@1236|Gammaproteobacteria,46885@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG1664 Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_416022_1 105559.Nwat_2908 1.43e-139 410.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1WWBG@135613|Chromatiales 135613|Chromatiales H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis ubiD - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_1555597_1 1280953.HOC_07872 0.000689 47.0 2CK39@1|root,32SBG@2|Bacteria,1MZ6F@1224|Proteobacteria,2UBT5@28211|Alphaproteobacteria,43YGI@69657|Hyphomonadaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - Phage_connect_1 k59_1404766_1 1120919.AUBI01000006_gene513 1.77e-25 107.0 COG0665@1|root,COG0665@2|Bacteria,1QWQF@1224|Proteobacteria,2U1W6@28211|Alphaproteobacteria 28211|Alphaproteobacteria E NAD(P)-binding Rossmann-like domain - - 1.5.99.6 ko:K00316 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R01914,R01915 RC00053,RC00225 ko00000,ko00001,ko01000 - - - NAD_binding_8 k59_986822_1 639282.DEFDS_1379 6.86e-15 71.2 COG3357@1|root,COG3357@2|Bacteria,2GG6P@200930|Deferribacteres 200930|Deferribacteres K Transcriptional regulator containing an HTH domain fused to a Zn-ribbon - - - ko:K07743 - - - - ko00000 - - - - k59_986822_2 706587.Desti_5305 2.14e-16 77.8 COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,42TGK@68525|delta/epsilon subdivisions,2WNGS@28221|Deltaproteobacteria,2MRXP@213462|Syntrophobacterales 28221|Deltaproteobacteria S Prolyl oligopeptidase family - - - ko:K06889 - - - - ko00000 - - - Abhydrolase_1,Hydrolase_4 k59_1349446_1 1118235.CAJH01000028_gene1981 6.94e-26 112.0 COG3300@1|root,COG5001@1|root,COG3300@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X3PH@135614|Xanthomonadales 135614|Xanthomonadales T GGDEF domain - - 2.7.7.65 ko:K21023 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - EAL,GGDEF,HAMP,MHYT k59_1425647_1 1117943.SFHH103_02842 4.23e-31 120.0 COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2TRSV@28211|Alphaproteobacteria,4BBRM@82115|Rhizobiaceae 28211|Alphaproteobacteria F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_1425647_2 1501391.LG35_04395 5.09e-07 50.1 COG0041@1|root,COG0041@2|Bacteria,4NME9@976|Bacteroidetes,2FMWN@200643|Bacteroidia 976|Bacteroidetes F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_1271255_1 1522072.IL54_0592 1.18e-32 124.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2TRXE@28211|Alphaproteobacteria,2K0DP@204457|Sphingomonadales 204457|Sphingomonadales J Belongs to the universal ribosomal protein uS2 family rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_849387_1 316067.Geob_2158 1.28e-40 139.0 COG0745@1|root,COG0745@2|Bacteria,1N1TA@1224|Proteobacteria,42V03@68525|delta/epsilon subdivisions,2WPZR@28221|Deltaproteobacteria,43V4S@69541|Desulfuromonadales 28221|Deltaproteobacteria T PFAM response regulator receiver cheY40H-1 - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_849387_2 1304880.JAGB01000001_gene210 5.95e-10 67.4 COG0643@1|root,COG0643@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia 186801|Clostridia T Signal transducing histidine kinase homodimeric cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,P2 k59_1479275_1 436308.Nmar_0050 3.35e-120 352.0 COG2046@1|root,arCOG04191@2157|Archaea,41SER@651137|Thaumarchaeota 651137|Thaumarchaeota P Belongs to the sulfate adenylyltransferase family sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_1479275_2 709032.Sulku_1056 2.78e-56 182.0 COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,42PUJ@68525|delta/epsilon subdivisions,2YN9G@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria EH Reduction of activated sulfate into sulfite cysH - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_1318328_2 445685.E3SKD1_9CAUD 1.62e-08 51.6 4QF9M@10239|Viruses,4R0PJ@35237|dsDNA viruses no RNA stage,4QRT5@28883|Caudovirales,4QK88@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1318328_3 444860.E3SIY5_9CAUD 2.59e-166 466.0 4QEZK@10239|Viruses,4QUSD@35237|dsDNA viruses no RNA stage,4QTHB@28883|Caudovirales,4QJXB@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_953389_1 194439.CT0147 9.98e-10 65.5 COG0821@1|root,COG0821@2|Bacteria,1FDH2@1090|Chlorobi 1090|Chlorobi H Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_117993_1 234267.Acid_5798 4.96e-61 214.0 COG0841@1|root,COG0841@2|Bacteria,3Y79D@57723|Acidobacteria 57723|Acidobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_1110808_1 717785.HYPMC_3723 2.94e-28 121.0 COG1266@1|root,COG1266@2|Bacteria,1QNYJ@1224|Proteobacteria,2TVGU@28211|Alphaproteobacteria 28211|Alphaproteobacteria S CAAX amino terminal protease family protein - - - ko:K07052 - - - - ko00000 - - - Abi,Exosortase_EpsH k59_588154_1 1049564.TevJSym_ag00660 1.05e-46 171.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria 1236|Gammaproteobacteria P PFAM von Willebrand factor type A - - - ko:K02448 - - R00294 RC02794 ko00000 3.D.4.10 - - - k59_1371766_1 760568.Desku_2265 1.11e-17 85.5 COG3221@1|root,COG3221@2|Bacteria,1U41J@1239|Firmicutes,24NHA@186801|Clostridia,262QZ@186807|Peptococcaceae 186801|Clostridia P TIGRFAM phosphate phosphite phosphonate ABC transporters, periplasmic binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_485709_2 1123075.AUDP01000003_gene616 4.51e-07 51.2 COG1917@1|root,COG1917@2|Bacteria,1VGJQ@1239|Firmicutes,25EGC@186801|Clostridia,3WSQC@541000|Ruminococcaceae 186801|Clostridia S Cupin domain protein - - - - - - - - - - - - Cupin_2 k59_1318332_1 572477.Alvin_1226 2.62e-13 76.6 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1WWWJ@135613|Chromatiales 135613|Chromatiales O HflC and HflK could encode or regulate a protease - - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_1217335_1 335283.Neut_1110 1.25e-56 183.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2VK46@28216|Betaproteobacteria,3721J@32003|Nitrosomonadales 28216|Betaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_485719_1 65489.OBART02G31020.1 3.18e-17 86.3 COG0616@1|root,2QQH5@2759|Eukaryota,37JSU@33090|Viridiplantae,3GEMR@35493|Streptophyta,3KTYV@4447|Liliopsida,3IF4C@38820|Poales 35493|Streptophyta OU Peptidase family S49 - GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009507,GO:0009526,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0009941,GO:0016020,GO:0016787,GO:0017171,GO:0019538,GO:0031967,GO:0031975,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_1523979_1 1089551.KE386572_gene4511 2.9e-40 144.0 COG4857@1|root,COG4857@2|Bacteria,1MXBW@1224|Proteobacteria,2TR0Z@28211|Alphaproteobacteria,4BRV5@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_535789_1 1692.BMAGN_0154 1.4e-12 75.5 COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4CYR0@85004|Bifidobacteriales 201174|Actinobacteria H Thiamine pyrophosphate enzyme, central domain ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_380240_1 443143.GM18_0178 7.66e-40 144.0 COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,42QEX@68525|delta/epsilon subdivisions,2WMFU@28221|Deltaproteobacteria,43S45@69541|Desulfuromonadales 28221|Deltaproteobacteria H A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response srkA - - - - - - - - - - - APH k59_380240_2 1280949.HAD_02415 0.000337 42.0 COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,43WZS@69657|Hyphomonadaceae 28211|Alphaproteobacteria I COG1884 Methylmalonyl-CoA mutase, N-terminal domain subunit mutB - 5.4.99.63 ko:K14447 ko00630,ko01120,ko01200,map00630,map01120,map01200 M00373 R09292 RC02835 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase k59_431325_2 751994.AGIG01000035_gene362 8.91e-29 109.0 COG2010@1|root,COG2010@2|Bacteria,1N91W@1224|Proteobacteria,1SD5N@1236|Gammaproteobacteria,1JAGD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c soxX - - ko:K17223 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - Cytochrom_C,Cytochrome_CBB3 k59_645421_1 1163617.SCD_n02443 9.16e-60 208.0 COG3850@1|root,COG5001@1|root,COG3850@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,EAL,GGDEF,PAS,PAS_3 k59_1006453_1 1333998.M2A_0051 9.92e-15 73.6 COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,2U0CV@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - 1.14.13.235 ko:K22027 - - - - ko00000,ko01000 - - - Acyl-CoA_dh_2,Acyl-CoA_dh_N k59_1006453_2 1088721.NSU_2068 3.02e-46 160.0 COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2TUPH@28211|Alphaproteobacteria,2K2FJ@204457|Sphingomonadales 204457|Sphingomonadales I Enoyl-CoA hydratase isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_169013_1 378806.STAUR_1612 3.08e-54 186.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria,2YTW6@29|Myxococcales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_118909_1 1232683.ADIMK_3944 2.49e-35 140.0 COG0004@1|root,COG5001@1|root,COG0004@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,464Y3@72275|Alteromonadaceae 1236|Gammaproteobacteria T GGDEF domain - - 2.1.1.80,3.1.1.61 ko:K03320,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02000,ko02022,ko02035 1.A.11 - - Ammonium_transp,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_1372493_2 1280948.HY36_04450 1.29e-45 155.0 COG0346@1|root,COG0346@2|Bacteria,1R6IN@1224|Proteobacteria,2U85D@28211|Alphaproteobacteria,43Z3Y@69657|Hyphomonadaceae 28211|Alphaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_850124_1 1502770.JQMG01000001_gene535 2.26e-16 84.3 COG2199@1|root,COG2202@1|root,COG5001@1|root,COG2199@2|Bacteria,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS_9 k59_486622_1 436308.Nmar_0079 4.55e-80 251.0 COG1797@1|root,arCOG00106@2157|Archaea,41SBP@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - CbiA,GATase_3 k59_223384_1 104623.Ser39006_01679 1.8e-56 186.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,3ZZTY@613|Serratia 1236|Gammaproteobacteria F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475 TGT k59_223384_2 768066.HELO_1403 4.34e-147 426.0 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1XH6Q@135619|Oceanospirillales 135619|Oceanospirillales J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_275723_1 448385.sce0599 7.45e-81 249.0 COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,42NZ1@68525|delta/epsilon subdivisions,2WNX5@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate prpB - 4.1.3.30 ko:K03417 ko00640,map00640 - R00409 RC00286,RC00287 ko00000,ko00001,ko01000 - - - PEP_mutase k59_275723_2 1120956.JHZK01000025_gene2004 2.98e-103 317.0 COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,1JP1J@119043|Rhodobiaceae 28211|Alphaproteobacteria S MmgE/PrpD family MA20_23745 - - - - - - - - - - - MmgE_PrpD k59_169025_1 445961.IW15_00755 1.03e-68 225.0 COG0053@1|root,COG0053@2|Bacteria,4NEID@976|Bacteroidetes,1HY4C@117743|Flavobacteriia,3ZPBV@59732|Chryseobacterium 976|Bacteroidetes P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family fieF - - - - - - - - - - - Cation_efflux,ZT_dimer k59_169025_2 469371.Tbis_3442 3.55e-21 89.7 COG0801@1|root,COG0801@2|Bacteria,2H3G6@201174|Actinobacteria,4E3MQ@85010|Pseudonocardiales 201174|Actinobacteria H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK - 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 - - - FolB,HPPK k59_745440_1 1229909.NSED_01945 6.81e-99 300.0 COG5253@1|root,arCOG04169@2157|Archaea,41S9X@651137|Thaumarchaeota 651137|Thaumarchaeota U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - Plug_translocon,SecY k59_169033_1 985867.AEWF01000001_gene1693 2.55e-66 217.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2TSZ3@28211|Alphaproteobacteria,47EXV@766|Rickettsiales 766|Rickettsiales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_381162_1 357804.Ping_0487 1.95e-71 219.0 COG0655@1|root,COG0655@2|Bacteria,1RKK7@1224|Proteobacteria 1224|Proteobacteria S NAD(P)H dehydrogenase (quinone) activity - - - - - - - - - - - - FMN_red k59_1634302_1 886293.Sinac_7397 1.92e-21 93.6 COG1861@1|root,COG1861@2|Bacteria,2J3F7@203682|Planctomycetes 203682|Planctomycetes M PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_4 k59_588885_1 204669.Acid345_1591 6.53e-09 61.6 COG1989@1|root,COG1989@2|Bacteria,3Y4VX@57723|Acidobacteria,2JNZH@204432|Acidobacteriia 204432|Acidobacteriia NOU Bacterial Peptidase A24 N-terminal domain - - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_1634306_1 1237149.C900_02230 0.000167 50.1 COG0773@1|root,COG0773@2|Bacteria,4NE1V@976|Bacteroidetes,47KY0@768503|Cytophagia 976|Bacteroidetes M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1524493_2 1121451.DESAM_21287 6.18e-19 87.4 COG0746@1|root,COG0746@2|Bacteria,1RKCH@1224|Proteobacteria,42T8X@68525|delta/epsilon subdivisions,2WP3Q@28221|Deltaproteobacteria,2MB8C@213115|Desulfovibrionales 28221|Deltaproteobacteria H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA - 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_954206_1 1242864.D187_003557 9.02e-16 77.0 COG0665@1|root,COG0665@2|Bacteria,1NCJX@1224|Proteobacteria,431XD@68525|delta/epsilon subdivisions,2WWSZ@28221|Deltaproteobacteria,2YUQQ@29|Myxococcales 28221|Deltaproteobacteria E FAD dependent oxidoreductase - - 1.4.3.3 ko:K00273 ko00260,ko00311,ko00330,ko00472,ko01100,ko01130,ko04146,map00260,map00311,map00330,map00472,map01100,map01130,map04146 - R00366,R02457,R02894,R02923,R04221,R07400 RC00006,RC00018,RC00135 ko00000,ko00001,ko01000 - - - DAO k59_954206_2 700598.Niako_6585 3.36e-25 98.2 2AGY9@1|root,3176X@2|Bacteria,4NQD4@976|Bacteroidetes,1ISTG@117747|Sphingobacteriia 976|Bacteroidetes S TIGRFAM Gliding motility-associated protein, GldC gldC - - - - - - - - - - - - k59_1426582_2 631362.Thi970DRAFT_02347 3.83e-43 144.0 2F88A@1|root,340MG@2|Bacteria,1NXS1@1224|Proteobacteria,1SQ1P@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phosphoribosyl-ATP pyrophosphohydrolase - - - - - - - - - - - - MazG k59_1059400_1 1121479.AUBS01000005_gene2593 0.000117 43.9 COG1545@1|root,COG1545@2|Bacteria,1RB09@1224|Proteobacteria,2U5BV@28211|Alphaproteobacteria 28211|Alphaproteobacteria S nucleic-acid-binding protein containing a Zn-ribbon - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_1059400_2 247633.GP2143_03438 7.31e-53 177.0 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,1RN81@1236|Gammaproteobacteria,1JAH3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG0183 Acetyl-CoA acetyltransferase - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_588891_1 479435.Kfla_4289 2.57e-15 81.3 COG1404@1|root,COG4733@1|root,COG1404@2|Bacteria,COG4733@2|Bacteria,2GIRE@201174|Actinobacteria,4DSF1@85009|Propionibacteriales 201174|Actinobacteria O Subtilase family mycP - - ko:K14743 - - - - ko00000,ko01000,ko01002,ko03110 - - - Peptidase_S8 k59_695354_2 1144275.COCOR_06027 3.42e-25 101.0 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,42T24@68525|delta/epsilon subdivisions,2WPF8@28221|Deltaproteobacteria,2YV09@29|Myxococcales 28221|Deltaproteobacteria S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - ko:K11206 - - - - ko00000,ko01000 - - - CN_hydrolase k59_1162306_1 1049564.TevJSym_ao00360 4.16e-76 238.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria,1J50Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S related to Ser Thr protein kinases - GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_536473_1 1313301.AUGC01000019_gene745 6.04e-98 317.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes 976|Bacteroidetes EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_850172_1 1336208.JADY01000002_gene297 9.9e-39 140.0 COG0500@1|root,COG2226@2|Bacteria,1RGWI@1224|Proteobacteria,2U9MW@28211|Alphaproteobacteria,2JSQ9@204441|Rhodospirillales 204441|Rhodospirillales Q methyltransferase - - - - - - - - - - - - DUF429 k59_850172_2 1033743.CAES01000021_gene4820 6.23e-20 90.1 COG0514@1|root,COG0514@2|Bacteria,1TPN5@1239|Firmicutes,4H9QP@91061|Bacilli,26S11@186822|Paenibacillaceae 91061|Bacilli L DNA helicase recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind k59_1372547_1 1291050.JAGE01000001_gene2803 0.000116 49.7 2DQTZ@1|root,338NY@2|Bacteria,1VSGW@1239|Firmicutes,24C1G@186801|Clostridia 186801|Clostridia S Chaperone of endosialidase - - - - - - - - - - - - Peptidase_S74 k59_1218217_1 1124991.MU9_875 0.000179 49.3 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria 1236|Gammaproteobacteria MU type I secretion outer membrane protein, TolC tolC GO:0002790,GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008104,GO:0008150,GO:0009279,GO:0009306,GO:0009987,GO:0010033,GO:0014070,GO:0015031,GO:0015075,GO:0015267,GO:0015288,GO:0015318,GO:0015562,GO:0015688,GO:0015711,GO:0015833,GO:0015850,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022838,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032940,GO:0032991,GO:0033036,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0042886,GO:0042930,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0046618,GO:0046903,GO:0047485,GO:0050896,GO:0051179,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098796,GO:1901678,GO:1902495,GO:1990195,GO:1990196,GO:1990281,GO:1990351 - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - iAPECO1_1312.APECO1_3378,iEC042_1314.EC042_3326,iECOK1_1307.ECOK1_3463 OEP k59_1634338_1 742821.HMPREF9464_00454 1.31e-17 87.4 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,4PQ8N@995019|Sutterellaceae 28216|Betaproteobacteria S Peptidase family M48 yggG_1 - - - - - - - - - - - Peptidase_M48,TPR_19 k59_1111595_1 1300345.LF41_1679 1.42e-21 93.6 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,1X3GV@135614|Xanthomonadales 135614|Xanthomonadales O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group cyoE GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_1580973_1 396588.Tgr7_1165 8.14e-121 358.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1WX71@135613|Chromatiales 135613|Chromatiales I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_1580973_2 765910.MARPU_04945 9.28e-45 157.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1WW2V@135613|Chromatiales 135613|Chromatiales M zinc metalloprotease - - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_1059425_1 439235.Dalk_2276 3.32e-57 196.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2WJQS@28221|Deltaproteobacteria,2MI12@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family hynA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.12.2.1,1.12.5.1,1.12.7.2,1.12.99.6 ko:K00437,ko:K00533,ko:K05922,ko:K06281 ko00633,ko01120,map00633,map01120 - R00019,R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_1318917_1 195253.Syn6312_1978 4.68e-18 85.5 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,PS_pyruv_trans,Radical_SAM,SPASM k59_850200_1 330214.NIDE4179 5.09e-34 122.0 COG3026@1|root,COG3026@2|Bacteria 2|Bacteria T antisigma factor binding - - - ko:K03598 - - - - ko00000,ko03021 - - - DUF4412,FtsX,LolA_like,MucB_RseB,MucB_RseB_C,zf-HC2 k59_850200_2 68194.JNXR01000006_gene3517 4.16e-31 119.0 COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria 201174|Actinobacteria S alcohol dehydrogenase adhA - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_223446_1 1082933.MEA186_14662 4.64e-29 122.0 COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43HD6@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T DNA-binding transcriptional activator of the SARP family - - - - - - - - - - - - BTAD,Guanylate_cyc k59_432204_1 318167.Sfri_0251 3.1e-12 72.4 COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,1RQWB@1236|Gammaproteobacteria,2QA1Q@267890|Shewanellaceae 1236|Gammaproteobacteria O PFAM cytochrome oxidase assembly ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_536507_1 1203606.HMPREF1526_00123 6.55e-72 246.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,36DHP@31979|Clostridiaceae 186801|Clostridia L DNA polymerase dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1426641_1 454957.IA64_20215 4.16e-45 158.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1X43Q@135614|Xanthomonadales 135614|Xanthomonadales I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_1426641_2 203122.Sde_0810 2.96e-10 62.0 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,4650B@72275|Alteromonadaceae 1236|Gammaproteobacteria J Ribosomal protein L11 methyltransferase prmA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006480,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018011,GO:0018012,GO:0018022,GO:0018023,GO:0018193,GO:0018194,GO:0018205,GO:0019538,GO:0031365,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_335883_1 326427.Cagg_2532 2.81e-20 92.8 COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,3772K@32061|Chloroflexia 32061|Chloroflexia T histidine kinase A domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Response_reg k59_335883_2 1379701.JPJC01000037_gene1574 1.31e-06 54.3 COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K8Y6@204457|Sphingomonadales 204457|Sphingomonadales T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg k59_543651_1 1121447.JONL01000001_gene400 2.74e-06 48.9 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42MBP@68525|delta/epsilon subdivisions,2WJAJ@28221|Deltaproteobacteria,2M9MS@213115|Desulfovibrionales 28221|Deltaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_543651_2 2340.JV46_02960 4.02e-50 170.0 COG0398@1|root,COG0607@1|root,COG0398@2|Bacteria,COG0607@2|Bacteria,1MVF3@1224|Proteobacteria,1RSK1@1236|Gammaproteobacteria 1236|Gammaproteobacteria P SNARE associated Golgi protein ydjX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Rhodanese,SNARE_assoc k59_961326_1 285514.JNWO01000014_gene5612 9.39e-143 413.0 COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria 201174|Actinobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_910297_1 1229909.NSED_01430 5.1e-182 517.0 COG0260@1|root,arCOG04322@2157|Archaea,41SYD@651137|Thaumarchaeota 651137|Thaumarchaeota E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_857927_1 404589.Anae109_2481 1.05e-51 182.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIVD@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU General secretory system II, protein E domain protein pulE-3 - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1436414_1 314278.NB231_00250 6.18e-58 192.0 COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,1SKJ8@1236|Gammaproteobacteria,1X0FH@135613|Chromatiales 135613|Chromatiales F Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C k59_283511_2 1131553.JIBI01000007_gene1170 2.91e-39 132.0 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2W36E@28216|Betaproteobacteria,373BV@32003|Nitrosomonadales 28216|Betaproteobacteria O PPIC-type PPIASE domain ppiC - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3 k59_128062_1 637910.ROD_24991 6.15e-25 107.0 COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,1RP34@1236|Gammaproteobacteria,3WWZH@544|Citrobacter 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain yfhK GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 ko:K07711 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_496717_1 396588.Tgr7_2901 7.53e-19 91.3 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1X29W@135613|Chromatiales 135613|Chromatiales NT chemotaxis - - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_1490200_1 479434.Sthe_2481 4.17e-95 301.0 COG0145@1|root,COG0145@2|Bacteria,2G5KZ@200795|Chloroflexi,27XUM@189775|Thermomicrobia 189775|Thermomicrobia EQ Hydantoinaseoxoprolinase domain protein - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_1588746_1 436308.Nmar_1042 4.23e-26 97.8 arCOG08727@1|root,arCOG08727@2157|Archaea,41T57@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1588746_2 1229909.NSED_06120 7.32e-36 125.0 arCOG08726@1|root,arCOG08726@2157|Archaea,41STN@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_655536_1 1429046.RR21198_0544 1.15e-70 235.0 COG0243@1|root,COG0243@2|Bacteria,2GJWZ@201174|Actinobacteria,4FVUW@85025|Nocardiaceae 201174|Actinobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - iNJ661.Rv2900c Molybdopterin,Molydop_binding k59_655536_2 583345.Mmol_0121 9.47e-62 201.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2VH3Z@28216|Betaproteobacteria 28216|Betaproteobacteria C PFAM Alcohol dehydrogenase zinc-binding domain protein - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_1227029_1 118005.AWNK01000009_gene253 6.48e-98 298.0 COG2271@1|root,COG2271@2|Bacteria 2|Bacteria G transmembrane transporter activity sauU_1 - - - - - - - - - - - MFS_1 k59_596465_1 203122.Sde_2104 7.71e-37 136.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,463YH@72275|Alteromonadaceae 1236|Gammaproteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpdG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - iE2348C_1286.E2348C_4372,iJN746.PP_4187 Pyr_redox_2,Pyr_redox_dim k59_596465_2 999141.GME_06290 1.38e-43 155.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1XHYG@135619|Oceanospirillales 135619|Oceanospirillales C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1067076_1 247633.GP2143_17996 1.9e-34 125.0 COG0346@1|root,COG0346@2|Bacteria,1MW8Z@1224|Proteobacteria 1224|Proteobacteria E lactoylglutathione lyase activity - - - - - - - - - - - - Glyoxalase_3 k59_1324484_1 644966.Tmar_0092 8.53e-33 127.0 COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia,3WCTC@538999|Clostridiales incertae sedis 186801|Clostridia E Pyridoxal-phosphate dependent enzyme ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT_4,PALP k59_1118995_1 622637.KE124774_gene3542 2.54e-48 167.0 COG3385@1|root,COG3385@2|Bacteria,1QURV@1224|Proteobacteria,2TW56@28211|Alphaproteobacteria,371IT@31993|Methylocystaceae 28211|Alphaproteobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_496745_1 1201290.M902_0663 4.67e-36 135.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria 28221|Deltaproteobacteria G PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - DctM,DctQ k59_335921_2 1229909.NSED_09695 3.89e-40 133.0 arCOG11529@1|root,arCOG11529@2157|Archaea,41TAA@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_440878_1 1288494.EBAPG3_17760 7.23e-70 233.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,2VKKI@28216|Betaproteobacteria,372B1@32003|Nitrosomonadales 28216|Betaproteobacteria O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_1436453_1 1229909.NSED_06335 1.93e-136 394.0 COG0464@1|root,arCOG01307@2157|Archaea,41SA4@651137|Thaumarchaeota 651137|Thaumarchaeota D AAA domain (Cdc48 subfamily) - - - - - - - - - - - - AAA,MIT,Vps4_C k59_1490238_1 324057.Pjdr2_3817 8.44e-09 61.2 COG1309@1|root,COG1309@2|Bacteria,1V3R8@1239|Firmicutes,4HBEK@91061|Bacilli,26VIR@186822|Paenibacillaceae 91061|Bacilli K TetR family transcriptional regulator - - - - - - - - - - - - TetR_N k59_230706_1 1120949.KB903339_gene8006 5.9e-06 53.9 COG1131@1|root,COG1131@2|Bacteria,2GRE8@201174|Actinobacteria,4D905@85008|Micromonosporales 201174|Actinobacteria V COG1131 ABC-type multidrug transport system, ATPase component - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_10318_2 941449.dsx2_0319 7.18e-07 51.6 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,42QWG@68525|delta/epsilon subdivisions,2WMS0@28221|Deltaproteobacteria,2MG6K@213115|Desulfovibrionales 28221|Deltaproteobacteria P Plays a role in the regulation of phosphate uptake phoU - - ko:K02039 - - - - ko00000 - - - PhoU k59_857978_1 84531.JMTZ01000090_gene1943 7.02e-14 68.9 COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1SG29@1236|Gammaproteobacteria,1X727@135614|Xanthomonadales 135614|Xanthomonadales P COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske k59_857978_2 1174684.EBMC1_07045 5.54e-22 94.7 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria,2JZXP@204457|Sphingomonadales 204457|Sphingomonadales Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_3 k59_175183_2 690585.JNNU01000012_gene2100 6.09e-12 67.8 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TSME@28211|Alphaproteobacteria,4BCI0@82115|Rhizobiaceae 28211|Alphaproteobacteria E gamma-glutamyltransferase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_753013_1 365528.KB891148_gene4839 1.41e-80 249.0 COG2141@1|root,COG2141@2|Bacteria,2GMRE@201174|Actinobacteria,4EU7W@85013|Frankiales 201174|Actinobacteria C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Bac_luciferase k59_753013_2 262316.MAP_0679c 4.55e-25 97.8 COG1018@1|root,COG1018@2|Bacteria,2ISSZ@201174|Actinobacteria,23A3E@1762|Mycobacteriaceae 201174|Actinobacteria C ferredoxin fdxB - - - - - - - - - - - Fer2 k59_1119025_1 555779.Dthio_PD2463 2.56e-42 143.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,42SVI@68525|delta/epsilon subdivisions,2WP7T@28221|Deltaproteobacteria,2MBIE@213115|Desulfovibrionales 28221|Deltaproteobacteria J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_1119025_2 1499967.BAYZ01000041_gene2324 4.45e-56 179.0 COG0102@1|root,COG0102@2|Bacteria,2NPCI@2323|unclassified Bacteria 2|Bacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_1379703_1 472759.Nhal_2251 1.5e-111 328.0 COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,1RMYN@1236|Gammaproteobacteria,1X0DE@135613|Chromatiales 135613|Chromatiales M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_1324512_1 396588.Tgr7_1242 4.86e-07 52.4 COG0614@1|root,COG0614@2|Bacteria,1N7EM@1224|Proteobacteria 1224|Proteobacteria P PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_3 k59_1324512_2 861299.J421_6272 2.09e-50 181.0 28MSW@1|root,2ZB15@2|Bacteria,1ZUI9@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - k59_753021_1 331869.BAL199_03544 0.000212 43.5 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase barA - 2.7.13.1,2.7.13.3 ko:K05962,ko:K07716 ko02020,ko04112,map02020,map04112 M00511 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg k59_753021_2 429009.Adeg_0173 3.49e-95 299.0 COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,42J66@68295|Thermoanaerobacterales 186801|Clostridia T PFAM sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07714,ko:K10943 ko02020,ko05111,map02020,map05111 M00500,M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_858000_1 1501268.EW14_1861 1.28e-12 72.4 COG0463@1|root,COG0463@2|Bacteria,1G153@1117|Cyanobacteria,1MKG7@1212|Prochloraceae 1117|Cyanobacteria M Alternative locus ID - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 k59_812722_2 1515746.HR45_07875 2.8e-78 240.0 COG2259@1|root,COG2259@2|Bacteria,1RBZP@1224|Proteobacteria,1S28E@1236|Gammaproteobacteria,2Q9UR@267890|Shewanellaceae 1236|Gammaproteobacteria S PFAM DoxX family protein - - - - - - - - - - - - DoxX k59_655622_1 1202962.KB907165_gene2172 7.61e-06 47.4 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0000287,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019899,GO:0022613,GO:0032296,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_655622_2 765911.Thivi_0610 6.5e-53 176.0 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1WW0G@135613|Chromatiales 135613|Chromatiales J An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_961415_1 1121949.AQXT01000002_gene1270 6.78e-43 145.0 COG2391@1|root,COG2391@2|Bacteria,1MZC0@1224|Proteobacteria,2U99K@28211|Alphaproteobacteria,43Y6H@69657|Hyphomonadaceae 28211|Alphaproteobacteria S transporter component - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_961415_2 748280.NH8B_3884 2.37e-18 79.3 COG2391@1|root,COG2391@2|Bacteria,1MZ3A@1224|Proteobacteria,2VSDD@28216|Betaproteobacteria,2KRR7@206351|Neisseriales 206351|Neisseriales S transporter component - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_596531_1 545264.KB898754_gene1836 8.17e-71 233.0 COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,1RZ0U@1236|Gammaproteobacteria,1WW7B@135613|Chromatiales 135613|Chromatiales C reductase, alpha subunit - - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1588815_2 557599.MKAN_00620 2.03e-15 74.3 COG3070@1|root,COG3070@2|Bacteria,2IKKV@201174|Actinobacteria,239W9@1762|Mycobacteriaceae 201174|Actinobacteria K TfoX N-terminal domain - - - - - - - - - - - - TfoX_N k59_543742_1 330214.NIDE1362 3.02e-68 229.0 COG2844@1|root,COG2844@2|Bacteria 2|Bacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.42,2.7.7.59,2.7.7.89 ko:K00982,ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_1227130_1 283942.IL2205 1.48e-57 189.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,2QFG6@267893|Idiomarinaceae 1236|Gammaproteobacteria F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475 TGT k59_655634_1 1394178.AWOO02000005_gene3693 1.62e-121 357.0 COG0183@1|root,COG0183@2|Bacteria,2GJ0W@201174|Actinobacteria,4EHB7@85012|Streptosporangiales 201174|Actinobacteria I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - - k59_1490300_1 56780.SYN_02798 3.43e-71 237.0 COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria,2MQTZ@213462|Syntrophobacterales 28221|Deltaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom k59_1168151_1 246196.MSMEI_1270 7.95e-104 321.0 COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria,235H0@1762|Mycobacteriaceae 201174|Actinobacteria S peptidase S15 - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_858023_1 754476.Q7A_2829 4.42e-70 223.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,4602E@72273|Thiotrichales 72273|Thiotrichales M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_655645_1 1165096.ARWF01000001_gene1400 8.21e-27 104.0 COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2VT9I@28216|Betaproteobacteria,2KMX4@206350|Nitrosomonadales 206350|Nitrosomonadales G PFAM PTS system fructose subfamily IIA component - - 2.7.1.194 ko:K02821 ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 M00283,M00550 R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.7.1 - - EIIA-man k59_655645_2 1122164.JHWF01000001_gene1913 1.29e-24 95.5 COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,1SX88@1236|Gammaproteobacteria,1JEY3@118969|Legionellales 118969|Legionellales G PTS HPr component phosphorylation site ptsH - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr k59_496838_1 1298593.TOL_0138 3.14e-41 148.0 COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,1XHHT@135619|Oceanospirillales 135619|Oceanospirillales D Part of the ABC transporter FtsEX involved in cellular division ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_496838_2 472759.Nhal_2201 8.5e-23 95.5 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,1WWRE@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes rpoH - - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_1227147_1 1472716.KBK24_0136335 9.82e-58 196.0 COG0028@1|root,COG0028@2|Bacteria,1MWUB@1224|Proteobacteria,2VMC1@28216|Betaproteobacteria,1K2XV@119060|Burkholderiaceae 28216|Betaproteobacteria EH Belongs to the TPP enzyme family xsc - 2.3.3.15 ko:K03852 ko00430,map00430 - R05651 RC02903,RC02909 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1227147_2 197221.22294129 0.000661 41.6 COG0161@1|root,COG0161@2|Bacteria,1G1QE@1117|Cyanobacteria 1117|Cyanobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family bioA - 2.6.1.18,2.6.1.62 ko:K00822,ko:K00833 ko00280,ko00410,ko00640,ko00780,ko01100,map00280,map00410,map00640,map00780,map01100 M00123,M00573,M00577 R00907,R03231,R04187 RC00006,RC00008,RC00062,RC00160,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_440957_1 1040982.AXAL01000029_gene4285 2.66e-60 205.0 COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria,43KUU@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P L-lysine 6-monooxygenase (NADPH-requiring) - - - ko:K07222 - - - - ko00000 - - - Pyr_redox_3 k59_390847_1 1380394.JADL01000010_gene4236 4.67e-98 305.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2TTAY@28211|Alphaproteobacteria,2JQ9T@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_442155_2 870187.Thini_1526 6.17e-62 201.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,1RVJU@1236|Gammaproteobacteria,461VP@72273|Thiotrichales 72273|Thiotrichales I Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus - - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_814004_1 1205680.CAKO01000004_gene3586 0.000568 42.4 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria,2JPZQ@204441|Rhodospirillales 204441|Rhodospirillales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_814004_2 1286106.MPL1_09712 1.96e-42 141.0 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,460PX@72273|Thiotrichales 72273|Thiotrichales J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_656958_1 765912.Thimo_1081 1.71e-135 399.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1WWUV@135613|Chromatiales 135613|Chromatiales E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_656958_2 1304872.JAGC01000009_gene1210 4.9e-25 101.0 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,42SD9@68525|delta/epsilon subdivisions,2WPPN@28221|Deltaproteobacteria,2MA4Y@213115|Desulfovibrionales 28221|Deltaproteobacteria H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3200 CTP_transf_like k59_231723_1 290397.Adeh_2740 1.02e-181 519.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,2YUHV@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_1437810_1 1033802.SSPSH_002143 2.62e-58 197.0 COG1073@1|root,COG1073@2|Bacteria,1PQAX@1224|Proteobacteria,1RZIS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S alpha beta - - - - - - - - - - - - Peptidase_S9 k59_859010_1 580340.Tlie_1468 6.44e-18 75.9 2DRHT@1|root,33BTG@2|Bacteria,3TBTK@508458|Synergistetes 508458|Synergistetes S lysine biosynthesis protein LysW - - - ko:K05826 - M00031,M00763 - - ko00000,ko00001,ko00002 - - - - k59_859010_2 1191523.MROS_0165 1.51e-18 83.2 COG0189@1|root,COG0189@2|Bacteria 2|Bacteria HJ Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) lysX - 6.3.1.17,6.3.2.32,6.3.2.41,6.3.2.43 ko:K05827,ko:K05844,ko:K14940,ko:K18310 ko00250,ko00300,ko00680,ko01100,ko01120,ko01210,ko01230,map00250,map00300,map00680,map01100,map01120,map01210,map01230 M00031 R09401,R09775,R10677,R10678 RC00064,RC00090,RC00141,RC03233 ko00000,ko00001,ko00002,ko01000,ko03009 - - - RimK k59_814019_1 926550.CLDAP_25890 1.34e-60 201.0 COG0665@1|root,COG0665@2|Bacteria,2G6HT@200795|Chloroflexi 200795|Chloroflexi E FAD dependent oxidoreductase - - 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO k59_824411_2 1122622.ATWJ01000010_gene1157 4.87e-12 68.9 COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4FECQ@85021|Intrasporangiaceae 201174|Actinobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_451670_1 351607.Acel_1952 8.22e-18 87.8 COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4ES6B@85013|Frankiales 201174|Actinobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_1445974_1 1229909.NSED_07770 7.06e-80 248.0 COG2237@1|root,arCOG04151@2157|Archaea,41SA3@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF373) - - - ko:K08975 - - - - ko00000 - - - DUF373 k59_969928_1 1229909.NSED_05640 1.34e-20 89.0 COG5012@1|root,arCOG03402@2157|Archaea 2157|Archaea T Cobalamin B12-binding domain protein - - - ko:K16955,ko:K22491 ko00920,map00920 - R09997 RC00035 ko00000,ko00001,ko03000 - - - B12-binding,B12-binding_2 k59_711318_1 522306.CAP2UW1_0296 1.24e-61 202.0 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,1KQNW@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon gluQ - - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c k59_92219_2 396588.Tgr7_1519 3.25e-113 332.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,1RNH2@1236|Gammaproteobacteria,1WWM8@135613|Chromatiales 135613|Chromatiales IQ TIGRFAM acetoacetyl-CoA reductase - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.36 ko:K00023 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R01779,R01977 RC00103,RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_1655130_1 1089551.KE386572_gene1955 1.39e-19 92.4 COG3119@1|root,COG3119@2|Bacteria,1MYHH@1224|Proteobacteria,2UA67@28211|Alphaproteobacteria 28211|Alphaproteobacteria P arylsulfatase activity - - - - - - - - - - - - Sulfatase k59_1387379_1 1150626.PHAMO_80087 1.95e-16 89.4 COG3941@1|root,COG3941@2|Bacteria,1PHQP@1224|Proteobacteria,2V9RW@28211|Alphaproteobacteria,2JWSI@204441|Rhodospirillales 204441|Rhodospirillales S Lambda phage tail tape-measure protein (Tape_meas_lam_C) - - - - - - - - - - - - Tape_meas_lam_C k59_1237889_1 330214.NIDE0623 7.06e-99 311.0 COG0653@1|root,COG0653@2|Bacteria,3J0E5@40117|Nitrospirae 40117|Nitrospirae U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_866302_1 997346.HMPREF9374_3999 8.72e-87 271.0 COG0385@1|root,COG0385@2|Bacteria,1TP85@1239|Firmicutes,4HBG6@91061|Bacilli 91061|Bacilli S Transporter - - - ko:K03453 - - - - ko00000 2.A.28 - - SBF k59_1501810_2 377629.TERTU_3439 1.45e-46 152.0 COG0347@1|root,COG0347@2|Bacteria,1RI28@1224|Proteobacteria,1S62Z@1236|Gammaproteobacteria,2PQD1@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria K Nitrogen regulatory protein P-II VV0993 - - - - - - - - - - - - k59_1501810_3 207954.MED92_02269 7.47e-57 184.0 arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,1RMI8@1236|Gammaproteobacteria,1XHVP@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_1294307_1 671143.DAMO_0750 1.1e-56 192.0 COG4122@1|root,COG4122@2|Bacteria,2NQFB@2323|unclassified Bacteria 2|Bacteria S Pup-ligase protein dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 ko:K20814 - - - - ko00000,ko01000,ko03051 - - - Pup_ligase k59_552299_1 1047013.AQSP01000095_gene2303 2.19e-42 160.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1331981_1 247490.KSU1_C0661 1.14e-68 227.0 COG0488@1|root,COG0488@2|Bacteria,2IX59@203682|Planctomycetes 203682|Planctomycetes S ABC transporter - - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_508521_1 1125863.JAFN01000001_gene2319 5.52e-35 128.0 COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,42TIF@68525|delta/epsilon subdivisions,2WQC4@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA-2 - 2.7.8.41 ko:K08744 ko00564,ko01100,map00564,map01100 - R02030 RC00002,RC00017 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_92246_1 1379270.AUXF01000005_gene820 6.3e-89 274.0 COG0195@1|root,COG0195@2|Bacteria,1ZSNN@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N k59_397465_1 1444310.JANV01000170_gene2322 4.83e-52 182.0 COG4467@1|root,COG4467@2|Bacteria,1VK8R@1239|Firmicutes,4HYEG@91061|Bacilli 91061|Bacilli S Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66,zf-IS66 k59_761219_1 330214.NIDE4362 2.03e-41 141.0 COG1611@1|root,COG1611@2|Bacteria,3J0TX@40117|Nitrospirae 40117|Nitrospirae S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - - k59_1446006_2 444875.E3SME9_9CAUD 6.11e-08 51.2 4QDM5@10239|Viruses,4QWZM@35237|dsDNA viruses no RNA stage,4QSG8@28883|Caudovirales,4QNZS@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_1537318_1 1173701.A0A066XS89 9.74e-15 79.0 COG4295@1|root,2RY71@2759|Eukaryota,3A10F@33154|Opisthokonta,3P2EQ@4751|Fungi,3RN1D@4890|Ascomycota,21R83@147550|Sordariomycetes,1F7MT@1028384|Glomerellales 4751|Fungi S Uncharacterized protein conserved in bacteria (DUF2263) - - - - - - - - - - - - DUF2263 k59_1537318_2 1155718.KB891885_gene6311 1.08e-24 101.0 COG1397@1|root,COG1397@2|Bacteria,2GKHI@201174|Actinobacteria 201174|Actinobacteria O PFAM ADP-ribosylation Crystallin J1 - - - - - - - - - - - - ADP_ribosyl_GH k59_451738_1 1323663.AROI01000009_gene3521 6.75e-33 124.0 COG0189@1|root,COG0189@2|Bacteria,1MVDU@1224|Proteobacteria,1RR7D@1236|Gammaproteobacteria 1236|Gammaproteobacteria HJ Alpha-L-glutamate PA1766 - - - - - - - - - - - ATPgrasp_ST k59_824492_1 1469245.JFBG01000080_gene290 7.49e-12 64.3 COG1163@1|root,COG1163@2|Bacteria,1RFPD@1224|Proteobacteria 1224|Proteobacteria S TGS domain - - - ko:K06944 - - - - ko00000 - - - MMR_HSR1,TGS k59_92272_1 1265505.ATUG01000001_gene3910 1.73e-08 57.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,2MIIU@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_92272_2 261292.Nit79A3_2611 7.32e-11 64.3 COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,2VK0H@28216|Betaproteobacteria,371QS@32003|Nitrosomonadales 28216|Betaproteobacteria S PFAM Cytochrome c assembly protein ypjD - - - - - - - - - - - Cytochrom_C_asm k59_1537328_1 1268635.Loa_02660 2.29e-62 205.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1JCB6@118969|Legionellales 118969|Legionellales S Insulinase (Peptidase family M16) ptrA - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1446026_1 1463857.JOFZ01000009_gene6217 0.000709 45.1 COG1051@1|root,COG1051@2|Bacteria 2|Bacteria F GDP-mannose mannosyl hydrolase activity - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_397489_1 398767.Glov_3106 6.7e-43 159.0 COG1129@1|root,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,43BJ5@68525|delta/epsilon subdivisions,2X713@28221|Deltaproteobacteria 28221|Deltaproteobacteria G PFAM ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_667411_1 379066.GAU_2212 4.33e-61 212.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1ZUC7@142182|Gemmatimonadetes 142182|Gemmatimonadetes QU Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,PD40 k59_552334_1 469382.Hbor_06340 6.31e-29 124.0 COG0642@1|root,arCOG02327@2157|Archaea,2XTH8@28890|Euryarchaeota,23S6Q@183963|Halobacteria 183963|Halobacteria T Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,HisKA_7TM,PAS_4 k59_508574_1 220664.PFL_3505 9.44e-08 54.7 COG1309@1|root,COG1309@2|Bacteria,1NCEF@1224|Proteobacteria,1RQ8N@1236|Gammaproteobacteria,1YMXT@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria K TetR family transcriptional regulator - - - ko:K22041 - - - - ko00000,ko03000 - - - TetR_N k59_346886_2 62928.azo1419 3.2e-41 147.0 COG3568@1|root,COG3568@2|Bacteria,1R8DZ@1224|Proteobacteria,2WGET@28216|Betaproteobacteria,2M04Q@206389|Rhodocyclales 206389|Rhodocyclales L Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_825912_1 571166.KI421509_gene2107 4.38e-46 164.0 COG0265@1|root,COG1716@1|root,COG0265@2|Bacteria,COG1716@2|Bacteria,1NT6K@1224|Proteobacteria,2UPAI@28211|Alphaproteobacteria 28211|Alphaproteobacteria OT Trypsin-like peptidase domain - - - - - - - - - - - - Trypsin_2 k59_183334_1 1123261.AXDW01000009_gene26 6.86e-90 282.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1X36F@135614|Xanthomonadales 135614|Xanthomonadales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_1078461_1 748247.AZKH_3028 6.88e-21 95.5 COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,2VPRW@28216|Betaproteobacteria,2KY1Z@206389|Rhodocyclales 206389|Rhodocyclales M Protein of unknown function (DUF1302) - - - - - - - - - - - - DUF1302 k59_1078461_2 1268239.PALB_27340 5.76e-21 93.6 28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria,2Q0C1@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_605444_1 349124.Hhal_1031 3.75e-20 95.1 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1WW36@135613|Chromatiales 135613|Chromatiales E PFAM NAD-glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_970986_1 686340.Metal_2559 1.04e-44 156.0 COG1533@1|root,COG1533@2|Bacteria,1NWJ9@1224|Proteobacteria,1SMJU@1236|Gammaproteobacteria,1XDZQ@135618|Methylococcales 135618|Methylococcales L radical SAM domain protein - - 4.1.99.14 ko:K03716 - - - - ko00000,ko01000 - - - - k59_183355_1 1493507.A0A0E3ICE3_9CAUD 7.29e-05 52.4 4QBUC@10239|Viruses,4QVRG@35237|dsDNA viruses no RNA stage,4QQGQ@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_921980_1 269799.Gmet_2580 2.96e-146 460.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_15224_1 243233.MCA0335 7.11e-72 242.0 COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PE6F@1224|Proteobacteria,1RWQP@1236|Gammaproteobacteria,1XDNM@135618|Methylococcales 135618|Methylococcales CEH 2 iron, 2 sulfur cluster binding - - - - - - - - - - - - Pyr_redox_2 k59_398409_2 1121097.JCM15093_1645 1.02e-59 208.0 COG3250@1|root,COG4225@1|root,COG3250@2|Bacteria,COG4225@2|Bacteria,4NESZ@976|Bacteroidetes,2FPDW@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolases family 2, TIM barrel domain - - 3.2.1.31 ko:K01195 ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142 M00014,M00076,M00077,M00078,M00129 R01478,R04979,R07818,R08127,R08260,R10830 RC00055,RC00171,RC00529,RC00530,RC00714,RC01251 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_294878_1 1379270.AUXF01000003_gene3624 3.53e-45 165.0 COG4993@1|root,COG4993@2|Bacteria,1ZSSJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PQQ-like domain - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 k59_1176737_1 100226.SCO7601 8.3e-69 234.0 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria 201174|Actinobacteria J Belongs to the amidase family - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_971025_1 1532557.JL37_16885 3.09e-28 115.0 COG0318@1|root,COG0318@2|Bacteria,1R6HT@1224|Proteobacteria,2VQR4@28216|Betaproteobacteria,3T58A@506|Alcaligenaceae 28216|Betaproteobacteria IQ Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II hcl - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_712435_1 1121028.ARQE01000005_gene2844 1.58e-35 139.0 COG0745@1|root,COG5002@1|root,COG0745@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_3,PAS_7,Response_reg k59_1295812_1 1121937.AUHJ01000012_gene2722 5.57e-126 370.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,1RNJH@1236|Gammaproteobacteria,46475@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG1960 Acyl-CoA dehydrogenases bbsG - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_346967_1 1242864.D187_009291 1.46e-52 178.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria,2YXED@29|Myxococcales 28221|Deltaproteobacteria E Belongs to the aspartate-semialdehyde dehydrogenase family asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1176759_1 105559.Nwat_3068 1.48e-52 171.0 COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1WYZ6@135613|Chromatiales 135613|Chromatiales S Belongs to the Smg family smg - - ko:K03747 - - - - ko00000 - - - DUF494 k59_1176759_2 1198232.CYCME_0324 1.65e-25 105.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,4608B@72273|Thiotrichales 72273|Thiotrichales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_15268_1 1071085.KK033114_gene398 5.83e-05 51.2 COG0665@1|root,arCOG00755@2157|Archaea,2XTIF@28890|Euryarchaeota,23SJR@183963|Halobacteria 183963|Halobacteria E COG0665 Glycine D-amino acid oxidases (deaminating) - - - - - - - - - - - - DAO k59_140032_1 1265505.ATUG01000001_gene4392 2.39e-41 142.0 2C477@1|root,32RDF@2|Bacteria,1RKW1@1224|Proteobacteria,42SWN@68525|delta/epsilon subdivisions,2WP88@28221|Deltaproteobacteria,2MNB4@213118|Desulfobacterales 28221|Deltaproteobacteria S DGC domain - - - - - - - - - - - - DGC k59_668911_1 1397666.RS24_01364 9.75e-63 215.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1538264_1 1123355.JHYO01000010_gene3480 5.06e-22 99.4 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,36Z67@31993|Methylocystaceae 28211|Alphaproteobacteria T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1078546_1 635013.TherJR_2457 8.49e-05 48.1 COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,2605U@186807|Peptococcaceae 186801|Clostridia U Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_1656739_1 656024.FsymDg_3275 1.06e-48 171.0 COG4992@1|root,COG4992@2|Bacteria,2GKE9@201174|Actinobacteria,4ES3J@85013|Frankiales 201174|Actinobacteria E TIGRFAM acetylornithine and succinylornithine argD GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0008150,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_605516_1 1121456.ATVA01000011_gene1777 2.52e-46 158.0 2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,42QRD@68525|delta/epsilon subdivisions,2WMYW@28221|Deltaproteobacteria,2MC9C@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF4197) - - - - - - - - - - - - DUF4197 k59_605516_2 1298880.AUEV01000008_gene2555 1.42e-05 51.6 COG3284@1|root,COG3284@2|Bacteria,2GJV4@201174|Actinobacteria 201174|Actinobacteria KQ Transcriptional activator of acetoin glycerol metabolism - - - - - - - - - - - - GAF,Trans_reg_C k59_668925_2 436308.Nmar_1779 7.57e-46 152.0 COG1931@1|root,arCOG01043@2157|Archaea,41SRJ@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the UPF0201 family - - - ko:K09736 - - - - ko00000 - - - RNA_binding k59_922068_1 1268072.PSAB_03630 1.92e-11 69.7 COG2141@1|root,COG2141@2|Bacteria,1TRBN@1239|Firmicutes,4HBYT@91061|Bacilli,26W4T@186822|Paenibacillaceae 91061|Bacilli C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_347006_1 1121918.ARWE01000001_gene1837 6.76e-68 220.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43UCF@69541|Desulfuromonadales 28221|Deltaproteobacteria T response regulator pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_398479_1 349161.Dred_2950 3.45e-35 136.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,260X3@186807|Peptococcaceae 186801|Clostridia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1388449_1 748658.KB907319_gene713 8.3e-69 226.0 COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1X2EG@135613|Chromatiales 135613|Chromatiales P PUA-like domain - - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,ATP-sulfurylase,PUA_2 k59_826036_1 1026882.MAMP_01354 1.22e-47 167.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,460ES@72273|Thiotrichales 72273|Thiotrichales MU type I secretion outer membrane protein, TolC - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_826036_2 396588.Tgr7_3136 1.48e-23 98.6 COG3945@1|root,COG3945@2|Bacteria,1N0BD@1224|Proteobacteria,1SG9J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin k59_453153_1 1245471.PCA10_06920 1.97e-10 61.2 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1YD08@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Belongs to the FPP GGPP synthase family ispA GO:0003674,GO:0003824,GO:0004161,GO:0004337,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033383,GO:0033384,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045337,GO:0045338,GO:0071704,GO:0090407,GO:1901576 2.5.1.1,2.5.1.10,2.5.1.29 ko:K00795,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - iPC815.YPO3176,iSFV_1184.SFV_0386 polyprenyl_synt k59_453153_2 1049564.TevJSym_ad00750 7.36e-108 318.0 COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,1RNDY@1236|Gammaproteobacteria,1J9IK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Converts GTP to 7,8-dihydroneopterin triphosphate folE2 - 3.5.4.16 ko:K09007 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GCHY-1 k59_1295869_1 1221522.B723_01200 6.9e-66 219.0 COG0590@1|root,COG0590@2|Bacteria,1QRKQ@1224|Proteobacteria,1RUMI@1236|Gammaproteobacteria,1YRD0@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria FJ tRNA wobble adenosine to inosine editing - - - - - - - - - - - - - k59_1656763_1 338966.Ppro_2997 1.68e-46 171.0 COG3322@1|root,COG5001@1|root,COG3322@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,43U61@69541|Desulfuromonadales 28221|Deltaproteobacteria T CHASE4 domain - - - - - - - - - - - - CHASE4,EAL,GGDEF,PAS,PAS_4,PAS_9,dCache_1 k59_1295870_1 349124.Hhal_1466 1.87e-95 285.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,1RN0Z@1236|Gammaproteobacteria,1WW47@135613|Chromatiales 135613|Chromatiales J Belongs to the universal ribosomal protein uS2 family rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_1332996_1 404589.Anae109_1393 1.07e-26 113.0 COG0312@1|root,COG0312@2|Bacteria,1Q3C0@1224|Proteobacteria,4393A@68525|delta/epsilon subdivisions,2X495@28221|Deltaproteobacteria,2YYIX@29|Myxococcales 28221|Deltaproteobacteria S peptidase U62 modulator of DNA gyrase - - - - - - - - - - - - PmbA_TldD k59_247808_1 1415754.JQMK01000002_gene3456 7.92e-27 114.0 COG0457@1|root,COG0457@2|Bacteria,1QX0H@1224|Proteobacteria,1T32E@1236|Gammaproteobacteria,46D4D@72275|Alteromonadaceae 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_190251_1 1121033.AUCF01000001_gene2316 8.53e-54 182.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TRGU@28211|Alphaproteobacteria,2JQ94@204441|Rhodospirillales 204441|Rhodospirillales BQ COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl k59_1138340_1 1235788.C802_04099 1.56e-16 80.1 COG0809@1|root,COG0809@2|Bacteria,4NDZ5@976|Bacteroidetes,2FNJD@200643|Bacteroidia,4AP2T@815|Bacteroidaceae 976|Bacteroidetes H Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_1138340_2 207559.Dde_1785 4.9e-11 65.9 COG2385@1|root,COG2385@2|Bacteria,1RGJS@1224|Proteobacteria,42RZE@68525|delta/epsilon subdivisions,2WNH8@28221|Deltaproteobacteria,2MAVE@213115|Desulfovibrionales 28221|Deltaproteobacteria D Stage II sporulation protein - - - ko:K06381 - - - - ko00000 - - - SpoIID,TPR_6,TPR_8 k59_1513657_1 864069.MicloDRAFT_00031550 1.12e-20 92.4 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,1JU3M@119045|Methylobacteriaceae 28211|Alphaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_1513657_2 264198.Reut_A1827 5.88e-37 140.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VKM4@28216|Betaproteobacteria,1K523@119060|Burkholderiaceae 28216|Betaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_560785_1 105559.Nwat_1146 5.93e-45 150.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1WWXG@135613|Chromatiales 135613|Chromatiales L PFAM HNH endonuclease - - - - - - - - - - - - HNH_5 k59_560785_2 459495.SPLC1_S550190 2.83e-67 217.0 COG0436@1|root,COG0436@2|Bacteria,1G24E@1117|Cyanobacteria,1H6X1@1150|Oscillatoriales 1117|Cyanobacteria E PFAM Aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 k59_101536_1 143224.JQMD01000002_gene177 4.41e-09 64.3 COG3119@1|root,COG3119@2|Bacteria,4NFGI@976|Bacteroidetes 976|Bacteroidetes P COG3119 Arylsulfatase A - - - - - - - - - - - - DUF4976,Sulfatase k59_354933_2 314345.SPV1_14284 1.38e-35 129.0 COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria 1224|Proteobacteria EH Reduction of activated sulfate into sulfite cysH - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_460225_1 1009370.ALO_20602 2.35e-30 117.0 COG1039@1|root,COG1039@2|Bacteria,1TQBE@1239|Firmicutes,4H4G6@909932|Negativicutes 909932|Negativicutes L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhC - 3.1.26.4 ko:K03471 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_520371_2 28229.ND2E_1996 3.5e-05 48.1 COG1629@1|root,COG4771@2|Bacteria,1MUNK@1224|Proteobacteria,1RN9S@1236|Gammaproteobacteria,2Q7NI@267889|Colwelliaceae 1236|Gammaproteobacteria P PFAM TonB-dependent receptor, TonB-dependent receptor plug - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_521849_1 1278307.KB906999_gene13 2.39e-241 672.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,2QIGA@267894|Psychromonadaceae 1236|Gammaproteobacteria C Citrate synthase, C-terminal domain gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_19000_1 570417.WP0815 8.15e-07 52.8 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2U5BZ@28211|Alphaproteobacteria,47FEH@766|Rickettsiales 766|Rickettsiales L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_1454321_1 526227.Mesil_2957 3.76e-80 252.0 COG0156@1|root,COG0156@2|Bacteria,1WIXA@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide - GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1454321_2 526227.Mesil_2958 8.7e-45 154.0 COG0451@1|root,COG0451@2|Bacteria,1WNCR@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M PFAM NAD dependent epimerase dehydratase family - - 1.1.1.203 ko:K18981 ko00053,map00053 - R10841 RC00066 ko00000,ko00001,ko01000 - - - Epimerase k59_521857_1 1357272.AVEO02000062_gene277 6.33e-21 88.6 COG5642@1|root,COG5642@2|Bacteria,1RJWF@1224|Proteobacteria,1S6CI@1236|Gammaproteobacteria,1Z7P1@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S Protein of unknown function (DUF2384) - - - - - - - - - - - - DUF2384 k59_521857_2 1283300.ATXB01000001_gene692 8.12e-15 70.9 COG5654@1|root,COG5654@2|Bacteria,1N6P3@1224|Proteobacteria,1S7EU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S RES domain protein - - - - - - - - - - - - RES k59_461410_1 1535422.ND16A_0370 1.76e-89 284.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,2Q5VE@267889|Colwelliaceae 1236|Gammaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain narB - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1087548_1 1148.1001236 1.69e-38 146.0 COG0025@1|root,COG0569@1|root,COG0025@2|Bacteria,COG0569@2|Bacteria,1G21K@1117|Cyanobacteria,1H4XV@1142|Synechocystis 1117|Cyanobacteria P Sodium/hydrogen exchanger family nhaP - - - - - - - - - - iJN678.sll0556 Na_H_Exchanger,TrkA_N k59_1184097_1 1448857.JFAP01000007_gene500 5.78e-15 82.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,42M4X@68525|delta/epsilon subdivisions,2YMCF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_406696_1 436229.JOEH01000008_gene4327 6.45e-74 229.0 COG1028@1|root,COG1028@2|Bacteria,2GIX2@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - - ko:K07535 ko00362,ko01120,ko01220,map00362,map01120,map01220 M00540 R05582 RC00154 ko00000,ko00001,ko00002,ko01000 - - - adh_short_C2 k59_406696_2 710685.MycrhN_3985 1.74e-18 84.3 COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria,235DZ@1762|Mycobacteriaceae 201174|Actinobacteria P Rieske 2Fe-2S - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_191554_1 335543.Sfum_1202 1.58e-142 427.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MQB9@213462|Syntrophobacterales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1546485_1 330214.NIDE2655 7.73e-112 340.0 COG0840@1|root,COG2972@1|root,COG0840@2|Bacteria,COG2972@2|Bacteria,3J11V@40117|Nitrospirae 40117|Nitrospirae T Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - HAMP,MCPsignal k59_1395704_1 663610.JQKO01000031_gene2974 1.3e-10 58.5 COG4679@1|root,COG4679@2|Bacteria,1QMSB@1224|Proteobacteria,2UE5S@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Phage derived protein Gp49-like (DUF891) - - - - - - - - - - - - Gp49 k59_1395704_2 1385935.N836_10510 1.59e-28 106.0 COG3093@1|root,COG3093@2|Bacteria,1G9PT@1117|Cyanobacteria,1HDE3@1150|Oscillatoriales 1117|Cyanobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_37 k59_521902_1 5786.XP_003284275.1 5.13e-23 101.0 COG0624@1|root,KOG2275@2759|Eukaryota,3XEYQ@554915|Amoebozoa 554915|Amoebozoa E Peptidase dimerisation domain - - - ko:K13049 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_521902_2 1254432.SCE1572_04135 1.17e-55 184.0 COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,42NZ1@68525|delta/epsilon subdivisions,2WNX5@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate prpB - 4.1.3.30 ko:K03417 ko00640,map00640 - R00409 RC00286,RC00287 ko00000,ko00001,ko01000 - - - PEP_mutase k59_406718_1 1469245.JFBG01000020_gene1082 3.02e-106 318.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_304150_1 864073.HFRIS_014934 4.14e-74 237.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,472ND@75682|Oxalobacteraceae 28216|Betaproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_1184124_1 871963.Desdi_2811 8.8e-46 163.0 COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,260X6@186807|Peptococcaceae 186801|Clostridia M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1184124_2 644966.Tmar_0866 1.48e-31 125.0 COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,3WCHQ@538999|Clostridiales incertae sedis 186801|Clostridia M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_406732_1 314271.RB2654_09284 1.84e-19 89.0 COG0811@1|root,COG0811@2|Bacteria,1PPAP@1224|Proteobacteria,2TS0F@28211|Alphaproteobacteria 28211|Alphaproteobacteria U MotA/TolQ/ExbB proton channel family MA20_09275 - - - - - - - - - - - MotA_ExbB k59_521924_1 926562.Oweho_3388 1.89e-05 50.1 COG1215@1|root,COG1215@2|Bacteria,4NEG0@976|Bacteroidetes,1HXHU@117743|Flavobacteriia 976|Bacteroidetes M glycosyl transferase family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 k59_613686_1 331113.SNE_B24410 3.77e-68 224.0 COG0058@1|root,COG0058@2|Bacteria,2JFEH@204428|Chlamydiae 204428|Chlamydiae G Carbohydrate phosphorylase glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_1604480_1 404589.Anae109_4120 1.56e-90 277.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42N7U@68525|delta/epsilon subdivisions,2WJ81@28221|Deltaproteobacteria,2Z0MS@29|Myxococcales 28221|Deltaproteobacteria C Radical SAM superfamily - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_1032082_1 748658.KB907317_gene393 8.93e-90 276.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1WWHB@135613|Chromatiales 135613|Chromatiales E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_191602_1 1452718.JBOY01000046_gene1057 5.47e-128 380.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria 1236|Gammaproteobacteria P phosphate transport system permease pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_875622_1 296587.XP_002500037.1 0.00049 43.9 2EII9@1|root,2SNXY@2759|Eukaryota,37ZWI@33090|Viridiplantae,34M4T@3041|Chlorophyta 3041|Chlorophyta S Prohead core protein serine protease - - - - - - - - - - - - Peptidase_S77 k59_1139616_1 269796.Rru_A1606 6.76e-146 433.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria,2JQKB@204441|Rhodospirillales 204441|Rhodospirillales G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_1546538_1 317025.Tcr_0885 2.53e-19 85.5 COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,1RQ3P@1236|Gammaproteobacteria,461E9@72273|Thiotrichales 72273|Thiotrichales GK ROK family - - 2.7.1.2,2.7.1.4 ko:K00845,ko:K00847 ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R00760,R00867,R01600,R01786,R03920 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK k59_1546538_2 261292.Nit79A3_3404 6.73e-39 136.0 COG0406@1|root,COG0406@2|Bacteria 2|Bacteria G alpha-ribazole phosphatase activity gpmB - - - - - - - - - - - His_Phos_1 k59_1247306_1 314285.KT71_16026 2.49e-45 159.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,1J4MX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_1139619_1 444860.E3SJA0_9CAUD 1.53e-64 207.0 4QBQH@10239|Viruses,4QZ5U@35237|dsDNA viruses no RNA stage,4QU2Y@28883|Caudovirales,4QJJN@10662|Myoviridae 10662|Myoviridae S galactoside 2-alpha-L-fucosyltransferase activity - - - - - - - - - - - - - k59_1668853_1 314225.ELI_13875 2.3e-85 275.0 COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,2U2UJ@28211|Alphaproteobacteria,2KEDN@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent receptor plug - - - - - - - - - - - - Plug,TonB_dep_Rec k59_521970_1 671143.DAMO_0102 3.59e-21 98.2 COG4772@1|root,COG4772@2|Bacteria,2NRIP@2323|unclassified Bacteria 2|Bacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_356198_1 95619.PM1_0227110 3.97e-64 216.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - iJN746.PP_5217 PP_kinase,PP_kinase_C,PP_kinase_N k59_1087636_1 1265313.HRUBRA_02711 4.01e-45 161.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014,ko:K16087 - - - - ko00000,ko02000 1.B.14,1.B.14.2 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1668868_1 330214.NIDE3882 8.18e-103 310.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - ko:K12263 - - - - ko00000 - - - Cytochrome_CBB3,SirB k59_931267_2 1142394.PSMK_29110 4.4e-58 183.0 COG0197@1|root,COG0197@2|Bacteria,2IZPH@203682|Planctomycetes 203682|Planctomycetes J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_1668887_3 1122604.JONR01000023_gene4147 1.54e-41 152.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1X3W3@135614|Xanthomonadales 135614|Xanthomonadales L Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_148129_1 485915.Dret_0823 3.31e-42 157.0 COG1067@1|root,COG1340@1|root,COG1067@2|Bacteria,COG1340@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2M7U6@213115|Desulfovibrionales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K04076,ko:K04770 - - - - ko00000,ko01000,ko01002 - - - AAA_32,Lon_C,Mg_chelatase k59_561970_1 391625.PPSIR1_01162 2.54e-140 414.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,42M18@68525|delta/epsilon subdivisions,2WJUK@28221|Deltaproteobacteria,2YWYV@29|Myxococcales 28221|Deltaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B coxA - 1.10.3.10,1.9.3.1 ko:K02274,ko:K02298 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081,R11335 RC00016,RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6 - - COX1 k59_561970_2 1192034.CAP_2031 1.61e-44 155.0 COG1622@1|root,COG3474@1|root,COG1622@2|Bacteria,COG3474@2|Bacteria,1MWHZ@1224|Proteobacteria,42M7N@68525|delta/epsilon subdivisions,2WM4F@28221|Deltaproteobacteria,2YWGQ@29|Myxococcales 28221|Deltaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.10.3.10,1.9.3.1 ko:K02275,ko:K02297 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081,R11335 RC00016,RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.5,3.D.4.6 - - COX2,COX2_TM,COX_ARM,Cytochrom_C,Cytochrome_CBB3 k59_406807_1 1540221.JQNI01000002_gene1405 4.78e-101 306.0 COG1788@1|root,COG2057@1|root,COG1788@2|Bacteria,COG2057@2|Bacteria 2|Bacteria I CoA-transferase activity scoA_1 - 2.8.3.5,2.8.3.6 ko:K01027,ko:K01028,ko:K01031 ko00072,ko00280,ko00362,ko00650,ko01100,ko01120,map00072,map00280,map00362,map00650,map01100,map01120 - R00410,R02990 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_1087668_1 1288494.EBAPG3_2480 7.97e-34 119.0 COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2VR9K@28216|Betaproteobacteria,3734V@32003|Nitrosomonadales 28216|Betaproteobacteria S Protein of unknown function (DUF971) - - - - - - - - - - - - DUF971 k59_1087668_2 1192124.LIG30_3441 1.48e-08 55.1 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2VIT4@28216|Betaproteobacteria,1K1SS@119060|Burkholderiaceae 28216|Betaproteobacteria K phosphate regulon transcriptional regulatory protein PhoB phoB - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1546596_1 330214.NIDE3284 1.72e-117 368.0 COG3829@1|root,COG4191@1|root,COG5000@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,3J117@40117|Nitrospirae 40117|Nitrospirae T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - DUF3365,HAMP,HATPase_c,HisKA,PAS_4 k59_1340442_1 459495.SPLC1_S201490 9.24e-40 149.0 COG0306@1|root,COG0306@2|Bacteria,1G13U@1117|Cyanobacteria 1117|Cyanobacteria P PFAM phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_875684_1 216596.RL0811A 1.86e-46 163.0 COG0438@1|root,COG0438@2|Bacteria,1PEGM@1224|Proteobacteria,2U15S@28211|Alphaproteobacteria,4BFW6@82115|Rhizobiaceae 28211|Alphaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_1032152_1 301.JNHE01000026_gene3066 8.12e-08 58.9 COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVK@1236|Gammaproteobacteria,1YGP9@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Sulfatase-modifying factor enzyme 1 - - - ko:K20333 ko02024,map02024 - - - ko00000,ko00001 - - - FGE-sulfatase,Pkinase k59_1546605_1 1123393.KB891316_gene1879 8.15e-78 240.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2VHHI@28216|Betaproteobacteria,1KR9T@119069|Hydrogenophilales 119069|Hydrogenophilales E Methylenetetrahydrofolate reductase - - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_1604537_1 414684.RC1_3203 1.62e-15 81.3 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2TS41@28211|Alphaproteobacteria,2JPA9@204441|Rhodospirillales 204441|Rhodospirillales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_260885_2 998674.ATTE01000001_gene1691 1.49e-104 310.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,45ZWN@72273|Thiotrichales 72273|Thiotrichales IQ reductase fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_208238_1 1121403.AUCV01000024_gene3416 1.77e-37 137.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MUDN@1224|Proteobacteria,42N3H@68525|delta/epsilon subdivisions,2WJSC@28221|Deltaproteobacteria,2MPAJ@213118|Desulfobacterales 28221|Deltaproteobacteria P Rhodanese Homology Domain - - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B,Rhodanese k59_781764_1 1206725.BAFU01000244_gene146 6.92e-27 114.0 COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria,4G6BF@85025|Nocardiaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_886994_1 666686.B1NLA3E_15530 2.74e-36 135.0 COG0755@1|root,COG0755@2|Bacteria,1V4A6@1239|Firmicutes,4HHG4@91061|Bacilli,1ZDZJ@1386|Bacillus 91061|Bacilli O COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component - - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm k59_886994_2 552811.Dehly_0439 5.71e-08 55.8 COG2386@1|root,COG2386@2|Bacteria,2G6TN@200795|Chloroflexi 200795|Chloroflexi O PFAM cytochrome c-type biogenesis protein CcmB ccmB - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB k59_1562747_1 1040982.AXAL01000029_gene4286 8.56e-79 239.0 COG1765@1|root,COG1765@2|Bacteria,1RBJN@1224|Proteobacteria,2VF54@28211|Alphaproteobacteria,43MJG@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O OsmC-like protein - - - - - - - - - - - - OsmC k59_208257_1 224324.aq_2084 2.19e-21 94.0 COG0079@1|root,COG0079@2|Bacteria,2G3NA@200783|Aquificae 200783|Aquificae E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_208257_2 690850.Desaf_2708 7.32e-24 102.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2WIUD@28221|Deltaproteobacteria,2M8H0@213115|Desulfovibrionales 28221|Deltaproteobacteria M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_1562771_1 402881.Plav_2504 1.64e-45 157.0 COG2175@1|root,COG2175@2|Bacteria,1Q8GZ@1224|Proteobacteria,2VCP6@28211|Alphaproteobacteria,1JQ4Y@119043|Rhodobiaceae 28211|Alphaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family - - 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_1614417_1 452863.Achl_3221 0.000111 43.9 COG1801@1|root,COG1801@2|Bacteria,2GMSP@201174|Actinobacteria,1WBIC@1268|Micrococcaceae 201174|Actinobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 k59_1614417_2 1068980.ARVW01000001_gene1523 7.68e-51 169.0 COG1309@1|root,COG1309@2|Bacteria,2I8DJ@201174|Actinobacteria,4E33H@85010|Pseudonocardiales 201174|Actinobacteria K PFAM Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_260919_1 472759.Nhal_3177 4.45e-126 396.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_781792_1 864702.OsccyDRAFT_1522 3.95e-59 201.0 COG3547@1|root,COG3547@2|Bacteria,1G4RX@1117|Cyanobacteria,1HHM0@1150|Oscillatoriales 1117|Cyanobacteria L PFAM Transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_208298_1 404589.Anae109_4161 2.3e-38 147.0 COG3005@1|root,COG3005@2|Bacteria,1NT6I@1224|Proteobacteria,42YAG@68525|delta/epsilon subdivisions,2WTY3@28221|Deltaproteobacteria 28221|Deltaproteobacteria C denitrification pathway - - - - - - - - - - - - - k59_887038_1 269799.Gmet_2348 1.55e-37 140.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,42PCH@68525|delta/epsilon subdivisions,2WMQM@28221|Deltaproteobacteria,43TBC@69541|Desulfuromonadales 28221|Deltaproteobacteria M 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) kdtA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_N k59_1409955_1 196162.Noca_0105 6.64e-28 110.0 COG0095@1|root,COG0095@2|Bacteria,2IG61@201174|Actinobacteria,4DRJB@85009|Propionibacteriales 201174|Actinobacteria H Lipoate-protein ligase - - - - - - - - - - - - - k59_1198497_1 368408.Tpen_0832 1.27e-58 191.0 COG0330@1|root,arCOG01915@2157|Archaea,2XPQN@28889|Crenarchaeota 28889|Crenarchaeota O PFAM band 7 protein - - - - - - - - - - - - Band_7 k59_1354547_1 1157490.EL26_13090 8.07e-32 122.0 COG1242@1|root,COG1242@2|Bacteria,1TQ57@1239|Firmicutes,4H9N8@91061|Bacilli,278UE@186823|Alicyclobacillaceae 91061|Bacilli S Radical_SAM C-terminal domain ytqA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C k59_208397_1 298655.KI912266_gene5604 2.53e-41 149.0 COG0208@1|root,COG0208@2|Bacteria,2GJKZ@201174|Actinobacteria,4ETJ1@85013|Frankiales 201174|Actinobacteria F P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_1043535_1 1262539.V9LYU4_9CAUD 1.39e-39 144.0 4QFBT@10239|Viruses,4R09C@35237|dsDNA viruses no RNA stage,4QS8Z@28883|Caudovirales 28883|Caudovirales S 4Fe-4S single cluster domain - - - - - - - - - - - - - k59_1354558_1 1121918.ARWE01000001_gene1453 7.75e-07 58.2 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,42NG6@68525|delta/epsilon subdivisions,2WIRU@28221|Deltaproteobacteria,43TQY@69541|Desulfuromonadales 28221|Deltaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - - k59_1043558_1 1254432.SCE1572_38440 5.42e-63 211.0 COG1964@1|root,COG1964@2|Bacteria,1QE02@1224|Proteobacteria,42M4B@68525|delta/epsilon subdivisions,2WJDI@28221|Deltaproteobacteria,2YZG3@29|Myxococcales 28221|Deltaproteobacteria S 4Fe-4S single cluster domain - - - ko:K06937 - - - - ko00000,ko01000 - - - Fer4_12,Fer4_14,Radical_SAM k59_208458_1 997346.HMPREF9374_3137 3.07e-33 123.0 COG2135@1|root,COG2135@2|Bacteria,1TRRV@1239|Firmicutes,4HDUN@91061|Bacilli,27BZ9@186824|Thermoactinomycetaceae 91061|Bacilli S SOS response associated peptidase (SRAP) yoqW - - - - - - - - - - - SRAP k59_574124_2 626887.J057_21055 7.37e-20 91.3 COG3156@1|root,COG3156@2|Bacteria,1RBNV@1224|Proteobacteria,1S5US@1236|Gammaproteobacteria,46CQU@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG3156 Type II secretory pathway, component PulK xcpX - - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_1562974_1 1168065.DOK_09781 2.71e-10 64.7 COG3103@1|root,COG4991@2|Bacteria,1MX7M@1224|Proteobacteria,1RS74@1236|Gammaproteobacteria,1J630@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG3103 SH3 domain protein ygiM GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 - ko:K07184 - - - - ko00000 - - - SH3_3 k59_208492_1 998674.ATTE01000001_gene4452 1.03e-40 144.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,462M2@72273|Thiotrichales 72273|Thiotrichales L PFAM Transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_781925_1 228410.NE0329 7.14e-105 313.0 COG0535@1|root,COG0535@2|Bacteria,1MXM1@1224|Proteobacteria,2VNRX@28216|Betaproteobacteria,371QM@32003|Nitrosomonadales 28216|Betaproteobacteria S Domain of unknown function (DUF3463) hpnH - - - - - - - - - - - DUF3463,Fer4_14,Radical_SAM k59_887177_1 99598.Cal7507_3061 4.55e-34 127.0 COG0702@1|root,COG0702@2|Bacteria,1G22R@1117|Cyanobacteria,1HJWR@1161|Nostocales 1117|Cyanobacteria GM PFAM NmrA-like family - - - - - - - - - - - - NAD_binding_10 k59_781929_1 373994.Riv7116_5818 1.92e-99 319.0 COG1554@1|root,COG1554@2|Bacteria,1G0DN@1117|Cyanobacteria,1HIEI@1161|Nostocales 1117|Cyanobacteria G haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED - - 2.4.1.64 ko:K05342 ko00500,ko01100,map00500,map01100 - R02727 RC00049 ko00000,ko00001,ko01000 - GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m k59_781938_1 1229909.NSED_02730 6.37e-60 195.0 COG0351@1|root,arCOG00020@2157|Archaea,41SA1@651137|Thaumarchaeota 651137|Thaumarchaeota H Phosphomethylpyrimidine kinase - - 2.5.1.3,2.7.1.49,2.7.4.7 ko:K21219 ko00730,ko01100,map00730,map01100 - R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko01000 - - - Phos_pyr_kin,ThiP_synth k59_24738_1 396588.Tgr7_1832 6.98e-70 226.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WW5M@135613|Chromatiales 135613|Chromatiales EH Anthranilate synthase component I - - 2.6.1.85,4.1.3.27 ko:K01657,ko:K01665 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_208545_1 1493511.A0A0E3HHJ7_9CAUD 8.85e-40 141.0 4QAIK@10239|Viruses,4QPEB@28883|Caudovirales,4QHXI@10662|Myoviridae 10662|Myoviridae S hydrolase activity - - - - - - - - - - - - - k59_208545_2 268746.Q58ML0_BPPRM 8.36e-75 227.0 4QC5H@10239|Viruses,4QVHT@35237|dsDNA viruses no RNA stage,4QPNZ@28883|Caudovirales,4QHUK@10662|Myoviridae 10662|Myoviridae S sigma factor activity - - - - - - - - - - - - - k59_1614537_1 357808.RoseRS_0253 1.28e-21 92.0 COG0039@1|root,COG0039@2|Bacteria,2G61S@200795|Chloroflexi,374VR@32061|Chloroflexia 32061|Chloroflexia C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_1614537_2 520999.PROVALCAL_03942 1.32e-40 145.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,3Z8VY@586|Providencia 1236|Gammaproteobacteria C isocitrate dehydrogenase NADP K00031 icd GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144 Iso_dh k59_1354651_1 1128421.JAGA01000002_gene615 5.98e-17 81.6 COG0406@1|root,COG0406@2|Bacteria,2NRJK@2323|unclassified Bacteria 2|Bacteria G Phosphoglycerate mutase family - - 5.4.2.12 ko:K15634 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_1354651_3 204536.SULAZ_1052 9.35e-10 58.9 COG0127@1|root,COG0127@2|Bacteria,2G435@200783|Aquificae 200783|Aquificae F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like k59_208598_1 247634.GPB2148_498 1.02e-30 121.0 COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,1S52W@1236|Gammaproteobacteria 1236|Gammaproteobacteria I LssY C-terminus - - - - - - - - - - - - LssY_C k59_208598_2 1123070.KB899247_gene1442 1.4e-31 118.0 COG3637@1|root,COG3637@2|Bacteria 2|Bacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_781976_1 1297742.A176_02098 1.03e-07 57.8 COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,42QGY@68525|delta/epsilon subdivisions,2WKHR@28221|Deltaproteobacteria,2Z0V8@29|Myxococcales 28221|Deltaproteobacteria T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp k59_887236_1 1123368.AUIS01000006_gene599 8.8e-74 237.0 COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,1S03J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Major facilitator superfamily - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_1198643_1 1097668.BYI23_C005920 2.25e-99 300.0 COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2VKD1@28216|Betaproteobacteria,1JZRA@119060|Burkholderiaceae 28216|Betaproteobacteria C acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1198649_1 1124780.ANNU01000092_gene836 1.2e-11 67.4 COG3547@1|root,COG3547@2|Bacteria,4NGED@976|Bacteroidetes,47NI4@768503|Cytophagia 976|Bacteroidetes L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1410142_1 1123320.KB889704_gene9381 1.29e-30 123.0 COG0183@1|root,COG0183@2|Bacteria 2|Bacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - - k59_1198654_2 288000.BBta_7358 4.72e-36 143.0 2CIPC@1|root,2Z9HB@2|Bacteria,1R3W8@1224|Proteobacteria,2TST7@28211|Alphaproteobacteria,3JX31@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Pfam:DUF2029 - - - - - - - - - - - - GT87 k59_1198660_1 522306.CAP2UW1_2048 3.81e-68 217.0 COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2VK17@28216|Betaproteobacteria,1KQDR@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde ltaA - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_1043700_1 1229909.NSED_02465 1.5e-38 134.0 COG0007@1|root,arCOG00644@2157|Archaea,41S9J@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the precorrin methyltransferase family - - 2.1.1.107 ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000 - - - TP_methylase k59_1043700_2 1229909.NSED_02460 5.33e-92 277.0 COG0181@1|root,arCOG04299@2157|Archaea,41S6Z@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_1354709_1 518766.Rmar_2170 1.72e-54 186.0 COG1282@1|root,COG1282@2|Bacteria,4NHGZ@976|Bacteroidetes,1FJ60@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_574259_1 426716.JOAJ01000003_gene3425 1.38e-31 122.0 COG1257@1|root,COG1257@2|Bacteria,2ICG3@201174|Actinobacteria,4FYZD@85025|Nocardiaceae 201174|Actinobacteria I Hydroxymethylglutaryl-coenzyme A reductase - - 1.1.1.88 ko:K00054 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R02081 RC00004,RC00644 ko00000,ko00001,ko01000 - - - HMG-CoA_red k59_1563201_1 238854.Q5GQI8_BPSYP 4.85e-96 288.0 4QCWD@10239|Viruses,4QUQN@35237|dsDNA viruses no RNA stage,4QUCZ@28883|Caudovirales 28883|Caudovirales S DNA primase activity - - - - - - - - - - - - - k59_1410205_1 1123371.ATXH01000018_gene1411 3.99e-59 191.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_1563214_1 555387.C7BV04_9CAUD 4.12e-37 146.0 4QG4N@10239|Viruses,4QW7D@35237|dsDNA viruses no RNA stage,4QTUV@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_782047_1 177437.HRM2_10310 1.16e-79 252.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,43BJP@68525|delta/epsilon subdivisions,2WJWZ@28221|Deltaproteobacteria,2MI6E@213118|Desulfobacterales 28221|Deltaproteobacteria C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2,4.3.1.1 ko:K01679,ko:K01744 ko00020,ko00250,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00250,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R00490,R01082 RC00316,RC00443,RC02799 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_1563227_1 760192.Halhy_0465 2.62e-96 290.0 COG0620@1|root,COG0620@2|Bacteria,4NJAH@976|Bacteroidetes,1IZXY@117747|Sphingobacteriia 976|Bacteroidetes E COGs COG0620 Methionine synthase II (cobalamin-independent) - - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_2 k59_1354751_2 1229909.NSED_09425 1.06e-75 234.0 COG3794@1|root,arCOG08795@1|root,arCOG02926@2157|Archaea,arCOG08795@2157|Archaea 2157|Archaea C copper ion binding - - - - - - - - - - - - Copper-bind,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1 k59_33136_2 373994.Riv7116_2805 3.82e-82 276.0 COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1HKGJ@1161|Nostocales 1117|Cyanobacteria T TIGRFAM diguanylate cyclase (GGDEF) domain - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_7,PAS_8,PAS_9,Response_reg k59_33202_1 765913.ThidrDRAFT_4466 3.92e-66 216.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1SYV1@1236|Gammaproteobacteria,1X2IS@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_33225_1 1396858.Q666_03745 1.21e-66 211.0 COG2818@1|root,COG2818@2|Bacteria,1R3WB@1224|Proteobacteria,1RSAH@1236|Gammaproteobacteria,46502@72275|Alteromonadaceae 1236|Gammaproteobacteria L 3-methyladenine DNA glycosylase IV02_03670 - - - - - - - - - - - Adenine_glyco k59_33265_1 861299.J421_0758 7.84e-41 150.0 COG0364@1|root,COG0364@2|Bacteria 2|Bacteria G glucose-6-phosphate dehydrogenase activity zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_33514_1 498211.CJA_2551 7.92e-18 84.3 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1FGB3@10|Cellvibrio 1236|Gammaproteobacteria H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302,ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_3999 CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_33514_2 1123399.AQVE01000007_gene1174 1.55e-23 92.8 COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,1SCA2@1236|Gammaproteobacteria,4614I@72273|Thiotrichales 72273|Thiotrichales O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins - - - ko:K03676 - - - - ko00000,ko03110 - - - Glutaredoxin k59_33688_1 675812.VHA_002085 2.99e-92 292.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,1Y0DT@135623|Vibrionales 135623|Vibrionales G PQQ enzyme repeat - - - - - - - - - - - - PQQ k59_33871_1 187272.Mlg_1154 1.13e-45 167.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1WXN2@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) - - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_634405_2 379066.GAU_3509 4.3e-119 347.0 COG1484@1|root,COG1484@2|Bacteria,1ZV5D@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Bacterial dnaA protein - - - - - - - - - - - - IstB_IS21 k59_1416357_1 1288826.MSNKSG1_06638 1.92e-77 242.0 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,464YF@72275|Alteromonadaceae 1236|Gammaproteobacteria K Transcriptional regulator cysB GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363 - ko:K13634 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1518939_1 644076.SCH4B_1135 1.01e-83 257.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 k59_1261199_1 717774.Marme_2512 3.25e-09 63.5 COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1NPHH@1224|Proteobacteria,1RR8S@1236|Gammaproteobacteria,1XJCC@135619|Oceanospirillales 135619|Oceanospirillales T Response regulator receiver - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_423885_1 867845.KI911784_gene1685 1.43e-66 214.0 COG0167@1|root,COG0167@2|Bacteria,2G5T6@200795|Chloroflexi,3766V@32061|Chloroflexia 32061|Chloroflexia F Catalyzes the conversion of dihydroorotate to orotate - - 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_634421_1 765911.Thivi_3349 8.65e-45 164.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1WWG0@135613|Chromatiales 135613|Chromatiales L Helicase - - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,Helicase_C_2 k59_1364135_1 314278.NB231_13796 1.07e-61 199.0 COG3187@1|root,COG3650@1|root,COG3187@2|Bacteria,COG3650@2|Bacteria,1MXIV@1224|Proteobacteria 1224|Proteobacteria O Heat shock protein - - - ko:K03668 - - - - ko00000 - - - META,MliC,YscW k59_319908_1 667014.Thein_2205 4.06e-43 153.0 COG0533@1|root,COG0533@2|Bacteria,2GHJ1@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_894250_1 1131266.ARWQ01000001_gene1320 9.97e-35 131.0 COG0301@1|root,arCOG00038@2157|Archaea,41ST5@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - - - - - - - - - - - k59_1261212_1 1415780.JPOG01000001_gene123 7.6e-77 248.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,1X3DB@135614|Xanthomonadales 135614|Xanthomonadales L DNA helicase recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_1518947_1 1382356.JQMP01000001_gene1234 0.000363 43.5 COG0787@1|root,COG0787@2|Bacteria,2G66N@200795|Chloroflexi,27XRR@189775|Thermomicrobia 189775|Thermomicrobia M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids - - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_1518947_2 1137271.AZUM01000005_gene194 1.9e-43 155.0 COG0277@1|root,COG0277@2|Bacteria,2GKQR@201174|Actinobacteria,4DYBE@85010|Pseudonocardiales 201174|Actinobacteria C PFAM FAD binding domain - - - - - - - - - - - - FAD_binding_4 k59_1261215_2 1379698.RBG1_1C00001G0493 2.9e-120 369.0 COG1387@1|root,COG1387@2|Bacteria,2NNNK@2323|unclassified Bacteria 2|Bacteria L DNA polymerase X family polX - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP k59_160842_1 768671.ThimaDRAFT_4428 1.1e-61 202.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,1WZPM@135613|Chromatiales 135613|Chromatiales L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_894268_1 1188252.AJYK01000092_gene1763 4.88e-21 94.7 COG1196@1|root,COG1196@2|Bacteria,1QXH8@1224|Proteobacteria,1T3WP@1236|Gammaproteobacteria,1Y382@135623|Vibrionales 135623|Vibrionales D Protein of unknown function (DUF3450) - - - - - - - - - - - - DUF3450 k59_894268_2 1207055.C100_00225 2.57e-29 122.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U3JH@28211|Alphaproteobacteria,2K1GK@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_59874_1 370438.PTH_2426 7.61e-43 156.0 COG2801@1|root,COG2801@2|Bacteria,1TQH6@1239|Firmicutes,249ZV@186801|Clostridia,2637H@186807|Peptococcaceae 186801|Clostridia L PFAM Integrase catalytic - - - - - - - - - - - - HTH_32,Mu-transpos_C,rve k59_1209156_1 1248917.ANFX01000013_gene1472 1.79e-59 193.0 COG1024@1|root,COG1024@2|Bacteria,1N4N7@1224|Proteobacteria,2TS6T@28211|Alphaproteobacteria,2K1V0@204457|Sphingomonadales 204457|Sphingomonadales I enoyl-CoA hydratase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_580618_1 1131269.AQVV01000007_gene1064 1.85e-62 215.0 COG2132@1|root,COG2132@2|Bacteria 2|Bacteria Q Multicopper oxidase - - 1.16.3.3,1.7.2.1 ko:K00368,ko:K07233,ko:K22349 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Copper-bind,Cu-oxidase_2,Cu-oxidase_3 k59_737278_1 639030.JHVA01000001_gene2689 9.56e-09 55.8 COG1741@1|root,COG1741@2|Bacteria,3Y4MS@57723|Acidobacteria,2JKK8@204432|Acidobacteriia 204432|Acidobacteriia S Pirin C-terminal cupin domain - - - - - - - - - - - - Pirin,Pirin_C k59_737278_2 330214.NIDE0007 1.18e-83 249.0 COG0691@1|root,COG0691@2|Bacteria,3J0Q4@40117|Nitrospirae 40117|Nitrospirae O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB k59_737278_3 330214.NIDE0006 2.2e-22 90.9 COG5512@1|root,COG5512@2|Bacteria 2|Bacteria L Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives - - - - - - - - - - - - DUF721 k59_1155213_1 1196323.ALKF01000183_gene5298 7.35e-86 269.0 COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,4H9ZF@91061|Bacilli,26QJT@186822|Paenibacillaceae 91061|Bacilli C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK - 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_3077_1 1005395.CSV86_19133 2.98e-13 70.1 COG0594@1|root,COG0594@2|Bacteria,1MZQE@1224|Proteobacteria,1S90M@1236|Gammaproteobacteria,1YYRZ@136845|Pseudomonas putida group 1236|Gammaproteobacteria J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031974,GO:0031981,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_3077_2 227377.CBU_0001 3.23e-15 75.9 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1JCEX@118969|Legionellales 118969|Legionellales L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_1261251_2 1408823.AXUS01000018_gene3117 1.62e-27 112.0 COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,25R13@186804|Peptostreptococcaceae 186801|Clostridia S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_737289_1 2340.JV46_24610 1.17e-31 116.0 2AFCJ@1|root,315C6@2|Bacteria,1RH66@1224|Proteobacteria,1S9MI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF1841) - - - - - - - - - - - - DUF1841 k59_894292_1 258594.RPA1480 8.09e-48 166.0 COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,2U5HA@28211|Alphaproteobacteria,3K67Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes cpdA - 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos k59_791044_1 1121468.AUBR01000012_gene2593 6.67e-79 253.0 COG0365@1|root,COG0365@2|Bacteria,1UMN9@1239|Firmicutes,25GME@186801|Clostridia 186801|Clostridia I AMP-binding enzyme C-terminal domain - - 6.2.1.32 ko:K08295 ko00627,ko01120,map00627,map01120 - R00982 RC00004,RC00174 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_476077_1 330214.NIDE0867 1.6e-114 342.0 COG4775@1|root,COG4775@2|Bacteria,3J10P@40117|Nitrospirae 40117|Nitrospirae M Surface antigen - - - - - - - - - - - - Bac_surface_Ag k59_476077_2 330214.NIDE0866 7.76e-29 108.0 COG2854@1|root,COG2854@2|Bacteria,3J13Z@40117|Nitrospirae 40117|Nitrospirae Q Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_894298_1 381666.H16_B1842 1.49e-148 432.0 COG1884@1|root,COG1884@2|Bacteria,1Q9IN@1224|Proteobacteria,2VMDQ@28216|Betaproteobacteria,1KBHB@119060|Burkholderiaceae 28216|Betaproteobacteria I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_371679_1 58123.JOFJ01000003_gene2207 1.12e-47 168.0 COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,4EFPE@85012|Streptosporangiales 201174|Actinobacteria Q Cytochrome P450 - - 1.14.13.141 ko:K15981 ko00984,ko01120,map00984,map01120 - R09859,R11357 RC01216,RC03368 ko00000,ko00001,ko00199,ko01000 - - - p450 k59_371679_2 1122247.C731_0258 1.75e-20 93.2 COG2124@1|root,COG2124@2|Bacteria,2GNJI@201174|Actinobacteria,233T0@1762|Mycobacteriaceae 201174|Actinobacteria Q Cytochrome P450 - - - - - - - - - - - - p450 k59_1469389_1 314278.NB231_04135 4.8e-39 147.0 COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,1S0W8@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Mitochondrial fission ELM1 - - - ko:K07276 - - - - ko00000 - - - Mito_fiss_Elm1 k59_1469389_2 1232683.ADIMK_4183 5.2e-13 68.6 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,4661I@72275|Alteromonadaceae 1236|Gammaproteobacteria M Belongs to the KdsA family kdsA GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008676,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016043,GO:0016051,GO:0016053,GO:0016740,GO:0016765,GO:0019294,GO:0019752,GO:0022607,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046394,GO:0046400,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_476782_1 1123279.ATUS01000001_gene2455 1.38e-68 218.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RZ5E@1236|Gammaproteobacteria,1J8I4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H ApbE family - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_476782_2 1122212.AULO01000007_gene2331 1.62e-76 246.0 COG2067@1|root,COG2067@2|Bacteria,1PXPC@1224|Proteobacteria,1RQKS@1236|Gammaproteobacteria,1XHI3@135619|Oceanospirillales 135619|Oceanospirillales I Protein of unknown function (DUF3570) - - - - - - - - - - - - DUF3570 k59_1470279_1 279714.FuraDRAFT_3751 2.11e-78 249.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,2KPX7@206351|Neisseriales 206351|Neisseriales L DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_1262178_1 396588.Tgr7_1455 3e-149 451.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1WW51@135613|Chromatiales 135613|Chromatiales J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_1262178_2 378806.STAUR_4132 1.18e-07 52.4 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,42MB0@68525|delta/epsilon subdivisions,2WJ42@28221|Deltaproteobacteria,2YWE0@29|Myxococcales 28221|Deltaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF987.Gmet_1415 Phe_tRNA-synt_N,tRNA-synt_2d k59_895120_1 1030157.AFMP01000009_gene3656 2.18e-38 142.0 COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1QV6D@1224|Proteobacteria,2TTB1@28211|Alphaproteobacteria,2K8G7@204457|Sphingomonadales 204457|Sphingomonadales I 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III - - - - - - - - - - - - - k59_528946_1 1158762.KB898037_gene2176 8.88e-39 138.0 COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,1RMS7@1236|Gammaproteobacteria,1WWCG@135613|Chromatiales 135613|Chromatiales C PFAM Phosphoribulokinase uridine kinase - - 2.7.1.19 ko:K00855 ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200 M00165,M00166 R01523 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PRK k59_528946_2 640081.Dsui_1801 3.71e-19 84.7 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,2VPQ9@28216|Betaproteobacteria,2M01K@206389|Rhodocyclales 206389|Rhodocyclales D ATPase MipZ - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - CbiA k59_1104033_1 7213.XP_004518546.1 0.000551 50.1 COG0457@1|root,KOG1124@2759|Eukaryota,38CY4@33154|Opisthokonta,3BDZ9@33208|Metazoa,3CW1H@33213|Bilateria,41VA9@6656|Arthropoda,3SKNK@50557|Insecta,44XMA@7147|Diptera 33208|Metazoa S Tetratricopeptide repeat - - - - - - - - - - - - DUF1736,PMT_2,TPR_1,TPR_11,TPR_16,TPR_2,TPR_7,TPR_8 k59_372425_1 1493511.A0A0E3FMD1_9CAUD 6.25e-11 70.5 4QEE7@10239|Viruses,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae 10662|Myoviridae S Pfam:DUF4815 - - - - - - - - - - - - - k59_215659_1 1123248.KB893326_gene1314 2.05e-33 131.0 COG0405@1|root,COG0405@2|Bacteria,4NF2H@976|Bacteroidetes,1IP46@117747|Sphingobacteriia 976|Bacteroidetes E PFAM Gamma-glutamyltranspeptidase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_215659_2 862908.BMS_1112 2.37e-22 95.9 COG0477@1|root,COG2814@2|Bacteria,1R590@1224|Proteobacteria,42P8I@68525|delta/epsilon subdivisions,2WKQ6@28221|Deltaproteobacteria 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_998755_2 264462.Bd1201 1e-53 182.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42M0R@68525|delta/epsilon subdivisions,2MSUE@213481|Bdellovibrionales,2WJE6@28221|Deltaproteobacteria 213481|Bdellovibrionales C PFAM acyl-CoA dehydrogenase domain protein - - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_895131_1 202952.BBLI01000043_gene2745 1.79e-51 177.0 COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,1RMUX@1236|Gammaproteobacteria,3NJHS@468|Moraxellaceae 1236|Gammaproteobacteria E HMGL-like - - 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_895131_2 1469245.JFBG01000027_gene1468 1.71e-107 316.0 COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,1RN08@1236|Gammaproteobacteria,1X2PA@135613|Chromatiales 135613|Chromatiales EP Binding-protein-dependent transport system inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1051775_1 1116472.MGMO_8c00500 2.7e-34 126.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1XDWP@135618|Methylococcales 135618|Methylococcales E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_1051775_2 1123504.JQKD01000020_gene5635 4.33e-07 55.5 COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria,4ABTG@80864|Comamonadaceae 28216|Betaproteobacteria M Nlpbdapx family lipoprotein nlpB - - ko:K07287 - - - - ko00000,ko02000 1.B.33.1 - - Lipoprotein_18 k59_60852_1 1121456.ATVA01000011_gene1839 9.64e-28 112.0 COG1456@1|root,COG1456@2|Bacteria,1R6BH@1224|Proteobacteria,42NKF@68525|delta/epsilon subdivisions,2WJ72@28221|Deltaproteobacteria,2MA2C@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM CO dehydrogenase acetyl-CoA synthase delta subunit, TIM barrel - - 2.1.1.245 ko:K00197 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00357,M00377,M00422 R09096,R10219,R10243 RC00004,RC00113,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhD k59_1470311_2 323261.Noc_1108 1.83e-31 111.0 COG1598@1|root,COG1598@2|Bacteria,1NPTZ@1224|Proteobacteria 1224|Proteobacteria S PFAM Uncharacterised protein family UPF0150 - - - - - - - - - - - - - k59_1417166_1 1033802.SSPSH_003486 4.3e-54 182.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_738034_1 519989.ECTPHS_08016 2.68e-88 267.0 COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,1RP7S@1236|Gammaproteobacteria,1WW9P@135613|Chromatiales 135613|Chromatiales S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_792024_1 1415754.JQMK01000005_gene1767 4.3e-105 307.0 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,465DF@72275|Alteromonadaceae 1236|Gammaproteobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0003906,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0034644,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071214,GO:0071478,GO:0071482,GO:0071704,GO:0090304,GO:0104004,GO:0140097,GO:1901360 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_1210129_1 105422.BBPM01000047_gene1737 9.81e-50 171.0 COG1073@1|root,COG1926@1|root,COG1073@2|Bacteria,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,2NIHT@228398|Streptacidiphilus 201174|Actinobacteria S Phosphoribosyl transferase domain - - - ko:K07100 - - - - ko00000 - - - DLH,Pribosyltran k59_1210138_1 1459636.NTE_03113 4.47e-79 246.0 COG0136@1|root,arCOG00494@2157|Archaea,41SFD@651137|Thaumarchaeota 651137|Thaumarchaeota E aspartate-semialdehyde dehydrogenase - - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_528978_1 379066.GAU_2380 3.23e-20 90.5 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1ZSZ7@142182|Gemmatimonadetes 142182|Gemmatimonadetes CE Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3 k59_528978_2 1280953.HOC_18124 1.5e-28 113.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,43Z43@69657|Hyphomonadaceae 28211|Alphaproteobacteria C pyruvate flavodoxin ferredoxin oxidoreductase MA20_01045 - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_215687_1 754476.Q7A_2005 3.26e-73 227.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,1RP6E@1236|Gammaproteobacteria,460G9@72273|Thiotrichales 72273|Thiotrichales L Hydrolase, TatD family - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_687537_3 1210884.HG799462_gene8426 4.23e-08 55.5 COG1186@1|root,COG1186@2|Bacteria,2IZSY@203682|Planctomycetes 203682|Planctomycetes J chain release factor - - - - - - - - - - - - RF-1 k59_268216_1 1415166.NONO_c44030 1.69e-29 112.0 COG0346@1|root,COG0346@2|Bacteria,2IFZW@201174|Actinobacteria,4FWQG@85025|Nocardiaceae 201174|Actinobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase_4 k59_110771_1 931627.MycrhDRAFT_5113 3.95e-15 78.2 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - - - - - - - - - - - Methyltransf_11,Methyltransf_23 k59_274229_1 1235835.C814_00685 1.82e-42 148.0 COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia,3WGGC@541000|Ruminococcaceae 186801|Clostridia C domain protein nfnA - 1.18.1.2,1.19.1.1 ko:K00528,ko:K16951 ko00920,ko01120,map00920,map01120 - R00858,R10146,R10159 RC00065 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,NAD_binding_1 k59_274229_2 1187851.A33M_4208 6.76e-53 181.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,3FCY5@34008|Rhodovulum 28211|Alphaproteobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2 k59_430686_2 240016.ABIZ01000001_gene1414 7.2e-55 197.0 COG3108@1|root,COG3108@2|Bacteria 2|Bacteria S Peptidase M15 - - - - - - - - - - - - Peptidase_M15_3 k59_643548_1 883080.HMPREF9697_01366 9.95e-213 604.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,3JSS3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E GMC oxidoreductase - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_167634_1 1197906.CAJQ02000051_gene76 8.93e-17 84.7 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - AAA_16,Abhydrolase_1,DZR,Guanylate_cyc,TPR_4 k59_587491_1 232721.Ajs_0390 4.1e-35 139.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2VN8I@28216|Betaproteobacteria,4AA35@80864|Comamonadaceae 28216|Betaproteobacteria C FAD dependent oxidoreductase glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_6042_1 1108045.GORHZ_075_00200 6e-82 254.0 COG5361@1|root,COG5361@2|Bacteria,2HES3@201174|Actinobacteria,4GH56@85026|Gordoniaceae 201174|Actinobacteria S Protein of unknown function (DUF1214) - - - - - - - - - - - - DUF1214 k59_1478262_1 1121935.AQXX01000144_gene4417 9.14e-124 360.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,1RQN1@1236|Gammaproteobacteria,1XHGV@135619|Oceanospirillales 135619|Oceanospirillales S C4-dicarboxylate ABC transporter substrate-binding protein - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_587498_2 580332.Slit_1217 1.33e-51 166.0 COG2346@1|root,COG2346@2|Bacteria 2|Bacteria O COG2346, Truncated hemoglobins glbN GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008941,GO:0009056,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016491,GO:0016705,GO:0016708,GO:0017144,GO:0019825,GO:0020012,GO:0020037,GO:0030682,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042737,GO:0043207,GO:0044237,GO:0044248,GO:0044270,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046209,GO:0046210,GO:0046906,GO:0048037,GO:0050896,GO:0051213,GO:0051410,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0072593,GO:0075136,GO:0097159,GO:0098754,GO:1901363,GO:1901698,GO:2001057 - ko:K03406,ko:K06886 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - Bac_globin k59_1057901_1 330214.NIDE3769 8.17e-45 150.0 COG0529@1|root,COG0529@2|Bacteria 2|Bacteria P adenylylsulfate kinase activity cysC - 2.7.1.25,2.7.7.4 ko:K00860,ko:K00955 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase k59_848705_1 1177179.A11A3_08400 9.01e-10 58.5 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,1XJA3@135619|Oceanospirillales 135619|Oceanospirillales J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_848705_2 948565.AFFP02000030_gene1196 2.85e-47 155.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,1Y8GH@135625|Pasteurellales 135625|Pasteurellales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_6043_1 316274.Haur_0958 1.05e-09 61.2 COG1960@1|root,COG1960@2|Bacteria,2G6E5@200795|Chloroflexi,3763W@32061|Chloroflexia 32061|Chloroflexia C PFAM acyl-CoA dehydrogenase domain protein - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_6043_2 316274.Haur_0959 1.58e-68 223.0 COG1960@1|root,COG1960@2|Bacteria,2G8BF@200795|Chloroflexi,3763I@32061|Chloroflexia 32061|Chloroflexia C PFAM acyl-CoA dehydrogenase domain protein - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1371076_1 330214.NIDE0840 2.6e-109 324.0 COG0045@1|root,COG0045@2|Bacteria,3J0ZB@40117|Nitrospirae 40117|Nitrospirae F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_1270285_1 1121015.N789_10795 2.07e-60 191.0 COG3576@1|root,COG3576@2|Bacteria,1NBWC@1224|Proteobacteria,1S297@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM pyridoxamine 5-phosphate - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_1270285_2 1370121.AUWS01000029_gene2777 1.3e-41 154.0 COG0243@1|root,COG0243@2|Bacteria,2GJCK@201174|Actinobacteria,2376C@1762|Mycobacteriaceae 201174|Actinobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family bisC - 1.8.5.3,1.97.1.9 ko:K07306,ko:K07309,ko:K07310,ko:K08351 ko00450,ko00780,ko00920,ko01100,map00450,map00780,map00920,map01100 - R07229,R09501,R10127 RC02420,RC02555,RC03056 ko00000,ko00001,ko01000,ko02000 5.A.3.3,5.A.3.4 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_117033_1 1336235.JAEG01000007_gene1439 2.34e-73 228.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria,4BGGH@82115|Rhizobiaceae 28211|Alphaproteobacteria C Cysteine-rich domain - - - ko:K18928 - - - - ko00000 - - - CCG k59_744060_2 1006004.GBAG_4134 2.65e-16 80.9 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria 1236|Gammaproteobacteria L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N k59_693924_1 396588.Tgr7_2292 6.06e-113 338.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1WWN1@135613|Chromatiales 135613|Chromatiales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_274250_1 1380394.JADL01000007_gene4646 1.75e-113 335.0 COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,2TSNP@28211|Alphaproteobacteria,2JQK3@204441|Rhodospirillales 204441|Rhodospirillales G Binding-protein-dependent transport system inner membrane component - - - ko:K05814 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.3 - - BPD_transp_1 k59_901179_1 933262.AXAM01000008_gene1934 1.12e-21 92.0 COG1899@1|root,COG1899@2|Bacteria,1R3WQ@1224|Proteobacteria,42M57@68525|delta/epsilon subdivisions,2WJ6N@28221|Deltaproteobacteria,2MHW7@213118|Desulfobacterales 28221|Deltaproteobacteria O peptidyl-lysine modification to peptidyl-hypusine - - - - - - - - - - - - - k59_901179_2 1380346.JNIH01000009_gene1768 9.49e-27 107.0 COG2110@1|root,COG2110@2|Bacteria,2IFEC@201174|Actinobacteria 201174|Actinobacteria S domain protein lppD GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Macro k59_587511_1 234267.Acid_5749 1.64e-61 211.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 k59_800583_1 1163408.UU9_03133 6.32e-41 154.0 COG0657@1|root,COG0657@2|Bacteria,1QDQP@1224|Proteobacteria,1RQJR@1236|Gammaproteobacteria,1X5SS@135614|Xanthomonadales 135614|Xanthomonadales I Glycosyl hydrolase family 65, N-terminal domain - - 3.2.1.51 ko:K15923 ko00511,map00511 - - - ko00000,ko00001,ko01000 - GH95 - Glyco_hyd_65N_2 k59_1632639_1 667014.Thein_1320 1.05e-134 399.0 COG0064@1|root,COG0064@2|Bacteria,2GGT5@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_693931_1 767434.Fraau_2427 4.24e-68 213.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,1X2XT@135614|Xanthomonadales 135614|Xanthomonadales KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07660 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_1057911_1 644107.SL1157_0493 6.78e-140 418.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,4ND7R@97050|Ruegeria 28211|Alphaproteobacteria I Poly-beta-hydroxybutyrate polymerase N terminal phbC - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PHBC_N,PhaC_N k59_1479658_2 314345.SPV1_12290 4.98e-18 82.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria 1224|Proteobacteria BQ Including yeast histone deacetylase and acetoin utilization protein - - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl k59_536057_1 1122604.JONR01000017_gene4338 1.72e-43 157.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XCD8@135614|Xanthomonadales 135614|Xanthomonadales T Sigma-54 interaction domain - - - - - - - - - - - - Response_reg,Sigma54_activat k59_1006051_2 926550.CLDAP_18730 3.37e-33 128.0 COG1233@1|root,COG1233@2|Bacteria,2G5SE@200795|Chloroflexi 200795|Chloroflexi Q FAD dependent oxidoreductase - - - - - - - - - - - - Amino_oxidase k59_1580510_1 713587.THITH_11995 9.38e-33 116.0 COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,1SD0S@1236|Gammaproteobacteria,1WY53@135613|Chromatiales 135613|Chromatiales P Belongs to the DsrF TusC family dsrF - - ko:K07236 ko04122,map04122 - - - ko00000,ko00001,ko03016 - - - DrsE k59_1580510_2 400682.PAC_15704300 3.73e-52 166.0 COG1553@1|root,2TFVY@2759|Eukaryota,3AGV3@33154|Opisthokonta,3BWYG@33208|Metazoa 33208|Metazoa P DsrE/DsrF-like family - - - - - - - - - - - - DrsE k59_902157_1 298653.Franean1_3906 0.000461 41.6 COG1545@1|root,COG1545@2|Bacteria,2H68Y@201174|Actinobacteria,4EW9B@85013|Frankiales 201174|Actinobacteria S DUF35 OB-fold domain, acyl-CoA-associated - - - - - - - - - - - - DUF35_N,OB_aCoA_assoc k59_902157_2 365528.KB891148_gene4901 2.67e-73 231.0 COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria,4EU6Q@85013|Frankiales 201174|Actinobacteria I Thiolase, C-terminal domain - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_1161940_1 1415755.JQLV01000001_gene3696 2.95e-79 244.0 COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,1RQIM@1236|Gammaproteobacteria,1XIIF@135619|Oceanospirillales 135619|Oceanospirillales I COG1024 Enoyl-CoA hydratase carnithine racemase - - - - - - - - - - - - ECH_1 k59_953737_1 1245471.PCA10_27860 1.99e-42 142.0 COG1545@1|root,COG1545@2|Bacteria,1N2C8@1224|Proteobacteria,1SFMU@1236|Gammaproteobacteria,1YJTY@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S DUF35 OB-fold domain, acyl-CoA-associated - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_168627_1 760117.JN27_02295 8.33e-46 158.0 COG0614@1|root,COG0614@2|Bacteria,1N53X@1224|Proteobacteria,2VN8J@28216|Betaproteobacteria,476BP@75682|Oxalobacteraceae 28216|Betaproteobacteria P Periplasmic binding protein - - - - - - - - - - - - Peripla_BP_2 k59_431646_1 525368.HMPREF0591_2258 3.01e-39 150.0 COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,23787@1762|Mycobacteriaceae 201174|Actinobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_802009_1 557598.LHK_01244 6.08e-10 66.2 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2VQZ4@28216|Betaproteobacteria,2KRPA@206351|Neisseriales 206351|Neisseriales E Belongs to the aspartate-semialdehyde dehydrogenase family - - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_536076_1 1223542.GM1_026_00280 4.39e-11 68.2 COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4GANS@85026|Gordoniaceae 201174|Actinobacteria I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain fadB2 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006635,GO:0008150,GO:0008152,GO:0008610,GO:0008691,GO:0009056,GO:0009058,GO:0009062,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016042,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019395,GO:0019752,GO:0030258,GO:0030312,GO:0030497,GO:0032787,GO:0034440,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0072330,GO:0075136,GO:1901575,GO:1901576 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - iNJ661.Rv0468 3HCDH,3HCDH_N k59_644945_1 2340.JV46_05690 4.16e-215 601.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L L COG2826 Transposase and inactivated derivatives, IS30 family insI GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K07482 - - - - ko00000 - - - HTH_38,rve k59_1633782_2 405948.SACE_1612 2.23e-07 53.9 COG0471@1|root,COG0471@2|Bacteria,2GVHZ@201174|Actinobacteria,4E1BE@85010|Pseudonocardiales 201174|Actinobacteria P PFAM Sodium sulfate symporter transmembrane region - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_953751_1 1121004.ATVC01000003_gene513 1.12e-53 171.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2VRBD@28216|Betaproteobacteria,2KR19@206351|Neisseriales 206351|Neisseriales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_953751_2 930169.B5T_03780 1.53e-57 184.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,1XJA3@135619|Oceanospirillales 135619|Oceanospirillales J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_1372098_1 926569.ANT_14530 3.48e-20 90.5 COG2068@1|root,COG2068@2|Bacteria,2G6W9@200795|Chloroflexi 200795|Chloroflexi S 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase - - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_223026_1 1499967.BAYZ01000173_gene5813 7.66e-40 152.0 COG2304@1|root,COG2304@2|Bacteria,2NPZM@2323|unclassified Bacteria 2|Bacteria S Vault protein inter-alpha-trypsin domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - FecR,VIT,VWA,VWA_3 k59_380647_1 983920.Y88_2406 4.45e-27 108.0 COG0739@1|root,COG0739@2|Bacteria,1QVU7@1224|Proteobacteria,2TWJV@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Peptidase family M23 - - - ko:K06194 - - - - ko00000 1.A.34.1.2 - - LysM,Peptidase_M23 k59_644965_1 595460.RRSWK_00504 8.76e-18 87.4 COG0628@1|root,COG0628@2|Bacteria,2J103@203682|Planctomycetes 203682|Planctomycetes S membrane protein-putative a permease - - - - - - - - - - - - AI-2E_transport k59_1426081_1 497964.CfE428DRAFT_2938 1.55e-52 182.0 COG0770@1|root,COG0770@2|Bacteria,46SDF@74201|Verrucomicrobia 74201|Verrucomicrobia M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1524212_2 1229909.NSED_05675 2.71e-32 117.0 COG1846@1|root,arCOG03748@2157|Archaea,41T7R@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-binding transcription factor activity - - - - - - - - - - - - - k59_223034_1 396588.Tgr7_0880 1.01e-81 249.0 COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,1RRXT@1236|Gammaproteobacteria,1X2ET@135613|Chromatiales 135613|Chromatiales F Deoxynucleoside kinase - - - - - - - - - - - - dNK k59_223034_2 925775.XVE_2675 0.000177 43.5 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,1S63J@1236|Gammaproteobacteria,1X6UH@135614|Xanthomonadales 135614|Xanthomonadales H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK2 - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK k59_1372113_1 338963.Pcar_0657 1.06e-96 297.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2WJKH@28221|Deltaproteobacteria,43RYF@69541|Desulfuromonadales 28221|Deltaproteobacteria P Binding-protein-dependent transport system inner membrane component pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3333 k59_1058956_1 1123393.KB891333_gene2589 1.21e-22 90.5 COG2146@1|root,COG2146@2|Bacteria,1N72F@1224|Proteobacteria,2VTX8@28216|Betaproteobacteria,1KT8D@119069|Hydrogenophilales 119069|Hydrogenophilales P Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_1058956_2 264198.Reut_A2271 3.74e-09 60.5 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2VH94@28216|Betaproteobacteria,1K0M3@119060|Burkholderiaceae 28216|Betaproteobacteria OU peptidase, S49 sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_644977_1 1280950.HJO_16090 0.000636 41.2 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,43ZDV@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Sulfatase - - - - - - - - - - - - Sulfatase k59_588501_1 926560.KE387023_gene2723 8.38e-22 94.7 COG3437@1|root,COG3437@2|Bacteria,1WM50@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T HD domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,Response_reg k59_588501_2 246197.MXAN_6220 1.83e-14 76.3 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2YUFE@29|Myxococcales 28221|Deltaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_70328_2 395494.Galf_2722 9.28e-50 164.0 28WAT@1|root,2ZIB9@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_70328_3 1046724.KB889910_gene804 2.19e-27 109.0 292MF@1|root,2ZQ5C@2|Bacteria,1RCYR@1224|Proteobacteria,1S44V@1236|Gammaproteobacteria,46BI2@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3047) - - - - - - - - - - - - DUF3047 k59_536105_1 338963.Pcar_2980 5.69e-15 76.3 COG3222@1|root,COG3222@2|Bacteria,1RB1V@1224|Proteobacteria,42U9T@68525|delta/epsilon subdivisions,2WQPQ@28221|Deltaproteobacteria,43W3W@69541|Desulfuromonadales 28221|Deltaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2064) - - - ko:K09931 - - - - ko00000 - - - DUF2064 k59_745075_1 95619.PM1_0215235 3.25e-61 212.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_588509_1 697282.Mettu_1553 3.44e-165 490.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1XDWG@135618|Methylococcales 135618|Methylococcales J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_588509_2 1115512.EH105704_02_02700 3.34e-45 157.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,3XP3Y@561|Escherichia 1236|Gammaproteobacteria F riboflavin biosynthesis protein ribF GO:0003674,GO:0003824,GO:0003919,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008531,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0044237,GO:0070566 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iETEC_1333.ETEC_0025,iJN746.PP_0602 FAD_syn,Flavokinase k59_328057_1 1045855.DSC_12695 7.79e-53 173.0 COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,1S6WD@1236|Gammaproteobacteria,1X6GW@135614|Xanthomonadales 135614|Xanthomonadales O Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein dsbB - - ko:K03611 - - - - ko00000,ko03110 5.A.2.1 - - DsbB k59_168679_1 123899.JPQP01000023_gene3239 3.11e-47 159.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2VJN2@28216|Betaproteobacteria,3T1QF@506|Alcaligenaceae 28216|Betaproteobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_168679_2 349124.Hhal_2058 3.16e-41 147.0 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,1X08H@135613|Chromatiales 135613|Chromatiales P 3'(2'),5'-bisphosphate nucleotidase - - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_1633837_1 1101195.Meth11DRAFT_1303 1.16e-119 351.0 COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,2VI5F@28216|Betaproteobacteria,2KMFN@206350|Nitrosomonadales 206350|Nitrosomonadales M Putative methyltransferase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_1161987_1 187272.Mlg_1900 1.84e-100 313.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1WVW2@135613|Chromatiales 135613|Chromatiales O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_849778_1 710686.Mycsm_01123 0.000218 48.1 COG1595@1|root,COG1595@2|Bacteria,2GM8T@201174|Actinobacteria,2336F@1762|Mycobacteriaceae 201174|Actinobacteria K Belongs to the sigma-70 factor family. ECF subfamily sigD GO:0000988,GO:0000990,GO:0002791,GO:0003674,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0016987,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032879,GO:0032880,GO:0043254,GO:0044087,GO:0044419,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051171,GO:0051223,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0070201,GO:0080090,GO:0090087,GO:0140110,GO:1903506,GO:1903530,GO:2000112,GO:2000142,GO:2001141 - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_596822_2 398767.Glov_1640 6.22e-06 48.9 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU TIGRFAM type IV pilus assembly protein PilM pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_441281_1 105559.Nwat_0473 1.41e-58 192.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1T1HN@1236|Gammaproteobacteria,1WY5A@135613|Chromatiales 135613|Chromatiales V pfam abc - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_441281_2 1283300.ATXB01000001_gene1784 4.14e-67 213.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1XDJA@135618|Methylococcales 135618|Methylococcales S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 k59_858305_1 1121861.KB899926_gene2599 2.76e-14 71.6 COG0477@1|root,COG2814@2|Bacteria,1P3S4@1224|Proteobacteria,2TVAQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1 k59_858305_2 398527.Bphyt_4744 4.9e-09 58.2 COG0834@1|root,COG0834@2|Bacteria,1N2RR@1224|Proteobacteria,2VMGM@28216|Betaproteobacteria,1K282@119060|Burkholderiaceae 28216|Betaproteobacteria ET SMART extracellular solute-binding protein, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_596828_1 84531.JMTZ01000043_gene1220 1.13e-08 61.6 COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1QTVF@1224|Proteobacteria,1S10C@1236|Gammaproteobacteria,1XD60@135614|Xanthomonadales 135614|Xanthomonadales HP TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1643821_1 1387312.BAUS01000002_gene600 1.41e-19 90.5 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2VH6S@28216|Betaproteobacteria,2KKS1@206350|Nitrosomonadales 206350|Nitrosomonadales H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_1643821_2 519989.ECTPHS_05846 2.09e-43 146.0 COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,1S3WD@1236|Gammaproteobacteria,1WX65@135613|Chromatiales 135613|Chromatiales H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH - 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k59_858316_1 944481.JAFP01000001_gene845 2.64e-33 125.0 COG1060@1|root,COG1060@2|Bacteria,1QN23@1224|Proteobacteria,42M6Z@68525|delta/epsilon subdivisions,2WJ4C@28221|Deltaproteobacteria,2M6UQ@213113|Desulfurellales 28221|Deltaproteobacteria H Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate mqnE - 1.21.98.1,2.5.1.120,2.5.1.77 ko:K11779,ko:K11784,ko:K18285 ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120 M00378 R08588,R09396,R10667 RC00021,RC01381,RC02329,RC03002,RC03007,RC03234 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3391 Radical_SAM k59_858316_2 1408473.JHXO01000010_gene3581 1.17e-08 58.5 COG1237@1|root,COG1237@2|Bacteria,4NR2Y@976|Bacteroidetes,2G364@200643|Bacteroidia 976|Bacteroidetes S Metallo-beta-lactamase superfamily - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - Lactamase_B k59_285068_1 402881.Plav_0023 2.15e-52 177.0 COG1633@1|root,COG1633@2|Bacteria,1R02H@1224|Proteobacteria,2TYHQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_754449_1 1167006.UWK_02566 1.79e-96 291.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MI0N@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Acyl-CoA dehydrogenase - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1380962_1 323261.Noc_0843 8.16e-10 60.8 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNN9@1236|Gammaproteobacteria,1WWN7@135613|Chromatiales 135613|Chromatiales OU PFAM peptidase - - - ko:K04774 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49,Peptidase_S49_N k59_1380962_2 82654.Pse7367_0751 2.35e-07 53.5 COG4221@1|root,COG4221@2|Bacteria,1G4X7@1117|Cyanobacteria,1HHV2@1150|Oscillatoriales 1117|Cyanobacteria S PFAM short chain dehydrogenase - - - - - - - - - - - - adh_short k59_391172_2 1173024.KI912148_gene3077 2.9e-24 99.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_1531107_1 666681.M301_0615 7.29e-42 145.0 COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,2VIC9@28216|Betaproteobacteria,2KKMR@206350|Nitrosomonadales 206350|Nitrosomonadales S Converts GTP to 7,8-dihydroneopterin triphosphate folE2 - 3.5.4.16 ko:K09007 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GCHY-1 k59_1531107_2 1453501.JELR01000001_gene1995 8.73e-25 102.0 COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,1RNVU@1236|Gammaproteobacteria,465UD@72275|Alteromonadaceae 1236|Gammaproteobacteria S Pyrophosphatase mazG GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.9 ko:K04765 ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100 - R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323 RC00002 ko00000,ko00001,ko01000 - - iAF1260.b2781,iBWG_1329.BWG_2516,iE2348C_1286.E2348C_3048,iEC55989_1330.EC55989_3056,iECDH10B_1368.ECDH10B_2948,iECDH1ME8569_1439.ECDH1ME8569_2691,iECH74115_1262.ECH74115_4041,iECIAI1_1343.ECIAI1_2889,iECO103_1326.ECO103_3324,iECO111_1330.ECO111_3505,iECO26_1355.ECO26_3851,iECOK1_1307.ECOK1_3155,iECP_1309.ECP_2762,iECSE_1348.ECSE_3039,iECSP_1301.ECSP_3733,iECW_1372.ECW_m2990,iECs_1301.ECs3641,iEKO11_1354.EKO11_0987,iEcDH1_1363.EcDH1_0907,iEcE24377_1341.EcE24377A_3085,iEcHS_1320.EcHS_A2925,iEcolC_1368.EcolC_0931,iG2583_1286.G2583_3433,iJO1366.b2781,iJR904.b2781,iSBO_1134.SBO_2662,iSSON_1240.SSON_2938,iSbBS512_1146.SbBS512_E3092,iUMN146_1321.UM146_02665,iUMNK88_1353.UMNK88_3464,iUTI89_1310.UTI89_C3150,iWFL_1372.ECW_m2990,iY75_1357.Y75_RS14470,iZ_1308.Z4096 MazG k59_1015713_2 765910.MARPU_07835 2.82e-75 248.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales 135613|Chromatiales O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_391179_1 1232410.KI421420_gene3180 2.96e-12 64.3 COG1826@1|root,COG1826@2|Bacteria,1NI3F@1224|Proteobacteria,42VIZ@68525|delta/epsilon subdivisions,2WRC5@28221|Deltaproteobacteria,43SSF@69541|Desulfuromonadales 28221|Deltaproteobacteria U mttA/Hcf106 family tatB - - ko:K03116,ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_657525_1 525904.Tter_0099 4.33e-26 110.0 COG2379@1|root,COG2379@2|Bacteria,2NNQP@2323|unclassified Bacteria 2|Bacteria G MOFRL family ttuD - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_657525_2 315730.BcerKBAB4_4340 1.93e-25 104.0 COG1360@1|root,COG1360@2|Bacteria,1UXY4@1239|Firmicutes,4HCCI@91061|Bacilli,1ZB4F@1386|Bacillus 91061|Bacilli N Flagellar motor protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_1438369_1 395493.BegalDRAFT_1890 1.85e-137 412.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,45ZMF@72273|Thiotrichales 72273|Thiotrichales CP Proton-translocating NADH-quinone oxidoreductase, chain L - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_285107_3 292415.Tbd_2446 3.3e-15 71.6 COG3193@1|root,COG3193@2|Bacteria,1RJ3X@1224|Proteobacteria,2WFMV@28216|Betaproteobacteria 28216|Betaproteobacteria S Haem-degrading - - - - - - - - - - - - Haem_degrading k59_814617_1 1192034.CAP_0252 6.06e-64 209.0 COG1960@1|root,COG1960@2|Bacteria,1R3VD@1224|Proteobacteria,438GC@68525|delta/epsilon subdivisions,2X3R5@28221|Deltaproteobacteria,2YWWF@29|Myxococcales 28221|Deltaproteobacteria C Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1645361_1 1121396.KB892979_gene1655 1.12e-29 121.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MI2Z@213118|Desulfobacterales 28221|Deltaproteobacteria V Hydrophobe Amphiphile Efflux-1 (HAE1) Family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran,OEP k59_657545_1 985054.JQEZ01000002_gene3263 8.11e-79 247.0 COG1351@1|root,COG1351@2|Bacteria,1MWY8@1224|Proteobacteria,2TTER@28211|Alphaproteobacteria,4NB8K@97050|Ruegeria 28211|Alphaproteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_498743_1 1265313.HRUBRA_02135 1.07e-78 252.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria,1J8CG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3,TPR_16,TPR_19,TPR_8 k59_754497_1 991905.SL003B_3516 2.01e-133 396.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_82856_1 2002.JOEQ01000006_gene1317 5.58e-27 113.0 COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria,4EIDJ@85012|Streptosporangiales 201174|Actinobacteria M Penicillin-binding Protein dimerisation domain ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_285138_1 706587.Desti_5279 1.78e-63 199.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,2MRKN@213462|Syntrophobacterales 28221|Deltaproteobacteria J Belongs to the universal ribosomal protein uS5 family rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_1325691_1 349521.HCH_00283 1.69e-51 180.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1XHDN@135619|Oceanospirillales 135619|Oceanospirillales FP Belongs to the GppA Ppx family ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - HD,Ppx-GppA k59_1169311_2 243231.GSU0803 3.66e-57 197.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WJRZ@28221|Deltaproteobacteria,43SWM@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1381016_1 1123368.AUIS01000001_gene2072 5.23e-67 226.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,2NCC0@225057|Acidithiobacillales 225057|Acidithiobacillales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_1229075_2 330214.NIDE1407 3.78e-26 108.0 COG3063@1|root,COG3063@2|Bacteria 2|Bacteria NU photosynthesis - - - ko:K02453,ko:K02660 ko02020,ko02025,ko03070,ko05111,map02020,map02025,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15 - - ANAPC5,CarboxypepD_reg,HTH_18,OmpA,PD40,TPR_16,TPR_8,Wzy_C k59_754516_1 1121430.JMLG01000010_gene192 0.000701 44.7 COG0287@1|root,COG0287@2|Bacteria,1TPXG@1239|Firmicutes,248KX@186801|Clostridia,260K3@186807|Peptococcaceae 186801|Clostridia E PFAM Prephenate dehydrogenase tyrA - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - ACT,PDH k59_754516_2 373903.Hore_05050 8.02e-30 121.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,3WAEE@53433|Halanaerobiales 186801|Clostridia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family nolG - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1381020_1 1288963.ADIS_4107 1.04e-60 214.0 COG3264@1|root,COG3264@2|Bacteria,4NEAM@976|Bacteroidetes,47KYP@768503|Cytophagia 976|Bacteroidetes M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_657601_2 1254432.SCE1572_40085 1.7e-32 122.0 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,42SD7@68525|delta/epsilon subdivisions,2WPI5@28221|Deltaproteobacteria,2YVK5@29|Myxococcales 28221|Deltaproteobacteria K Belongs to the UPF0301 (AlgH) family - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_285150_1 1123504.JQKD01000089_gene784 1.13e-08 56.6 COG1028@1|root,COG1028@2|Bacteria,1R4UB@1224|Proteobacteria,2W0VZ@28216|Betaproteobacteria 28216|Betaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_1169326_1 211586.SO_0906 1.27e-31 116.0 COG2209@1|root,COG2209@2|Bacteria,1NTE2@1224|Proteobacteria,1SMEZ@1236|Gammaproteobacteria,2Q8U0@267890|Shewanellaceae 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol - - 1.6.5.8 ko:K00350 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_1169326_2 1317118.ATO8_05011 7.41e-23 94.4 COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,2U0DD@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrD - 1.6.5.8 ko:K00349 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_1229097_1 1500259.JQLD01000007_gene2542 5.88e-44 161.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase cyaF2 - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,TPR_16,TPR_19,TPR_2,TPR_8 k59_657607_1 1283299.AUKG01000002_gene4966 2.72e-70 232.0 COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4CSGP@84995|Rubrobacteria 84995|Rubrobacteria Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_1438451_1 445686.E3SL60_9CAUD 8.53e-80 259.0 4QAZ6@10239|Viruses,4QUU8@35237|dsDNA viruses no RNA stage,4QPHV@28883|Caudovirales,4QI4H@10662|Myoviridae 10662|Myoviridae S Phage tail sheath protein - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098027 - - - - - - - - - - - k59_1438451_2 444860.E3SJ07_9CAUD 1.65e-108 316.0 4QAQQ@10239|Viruses,4QVZX@35237|dsDNA viruses no RNA stage,4QPBX@28883|Caudovirales,4QIBM@10662|Myoviridae 10662|Myoviridae S T4-like virus tail tube protein gp19 - - - - - - - - - - - - - k59_1438451_3 444860.E3SJ08_9CAUD 4.16e-141 413.0 4QBAK@10239|Viruses,4QY34@35237|dsDNA viruses no RNA stage,4QQBQ@28883|Caudovirales,4QIQI@10662|Myoviridae 10662|Myoviridae S Bacteriophage T4-like capsid assembly protein (Gp20) - GO:0005575,GO:0019012 - - - - - - - - - - - k59_1169328_1 713586.KB900536_gene2727 1.47e-92 290.0 COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales 135613|Chromatiales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_82905_1 272134.KB731324_gene1809 9.16e-31 119.0 COG0330@1|root,COG0330@2|Bacteria,1G356@1117|Cyanobacteria,1HHF1@1150|Oscillatoriales 1117|Cyanobacteria O COG0330 Membrane protease subunits stomatin prohibitin homologs - - - - - - - - - - - - Band_7 k59_754539_1 1120999.JONM01000013_gene2150 1.37e-36 142.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,2KPCH@206351|Neisseriales 206351|Neisseriales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom k59_337485_2 671143.DAMO_0821 1.96e-50 173.0 COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria 2|Bacteria C Cytochrome b(N-terminal)/b6/petB petB - - ko:K00410,ko:K00412,ko:K02635,ko:K02637 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 - - ko00000,ko00001,ko00002,ko00194,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B k59_391243_1 1469245.JFBG01000069_gene32 3.32e-92 286.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1WWDG@135613|Chromatiales 135613|Chromatiales E TIGRFAM Acetolactate synthase, large subunit, biosynthetic - - - - - - - - - - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_657627_1 864073.HFRIS_014115 4.25e-96 287.0 COG1028@1|root,COG1028@2|Bacteria,1MWJI@1224|Proteobacteria,2VHU1@28216|Betaproteobacteria,473UI@75682|Oxalobacteraceae 28216|Betaproteobacteria IQ Short chain dehydrogenase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1229115_1 269799.Gmet_1389 6.66e-16 80.1 COG0392@1|root,COG0392@2|Bacteria,1R98C@1224|Proteobacteria,42U6V@68525|delta/epsilon subdivisions,2WKTZ@28221|Deltaproteobacteria,43W1F@69541|Desulfuromonadales 28221|Deltaproteobacteria S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_1229115_2 177439.DP1094 2.66e-68 222.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,42MV7@68525|delta/epsilon subdivisions,2WJTU@28221|Deltaproteobacteria,2MHYE@213118|Desulfobacterales 28221|Deltaproteobacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_545227_1 1120934.KB894404_gene801 1.45e-41 153.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4E23F@85010|Pseudonocardiales 201174|Actinobacteria Q Cytochrome P450 cyp23 - - - - - - - - - - - p450 k59_545227_2 1121346.KB899818_gene2571 1.01e-33 127.0 COG0136@1|root,COG0136@2|Bacteria,1TPC6@1239|Firmicutes,4HA9H@91061|Bacilli,26RSN@186822|Paenibacillaceae 91061|Bacilli E Belongs to the aspartate-semialdehyde dehydrogenase family asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_657637_1 1265313.HRUBRA_01563 1.24e-80 253.0 COG3547@1|root,COG3547@2|Bacteria,1QYJU@1224|Proteobacteria,1RN0A@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase IS116 IS110 IS902 - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1390680_2 365044.Pnap_1260 3.87e-09 65.5 COG4454@1|root,COG5569@1|root,COG4454@2|Bacteria,COG5569@2|Bacteria,1R91G@1224|Proteobacteria,2VSDP@28216|Betaproteobacteria,4AED8@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM Blue (type 1) copper domain - - - - - - - - - - - - Copper-bind,Cupredoxin_1,CusF_Ec k59_1506989_1 1125863.JAFN01000001_gene2404 1.28e-43 152.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,42MAG@68525|delta/epsilon subdivisions,2WM94@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Belongs to the TrpC family trpC - 4.1.1.48,5.3.1.24 ko:K01609,ko:K13498 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508,R03509 RC00944,RC00945 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2494 IGPS k59_1449230_1 589924.Ferp_0086 2.29e-85 271.0 COG0574@1|root,arCOG01114@2157|Archaea,2XVIT@28890|Euryarchaeota 28890|Euryarchaeota G PEP-utilising enzyme, mobile domain - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers k59_142595_2 1237149.C900_04681 1.93e-57 178.0 COG0051@1|root,COG0051@2|Bacteria,4NQ65@976|Bacteroidetes,47Q8W@768503|Cytophagia 976|Bacteroidetes J Involved in the binding of tRNA to the ribosomes rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_513580_1 717772.THIAE_03595 3.04e-13 66.6 COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,1SCHG@1236|Gammaproteobacteria,4614M@72273|Thiotrichales 72273|Thiotrichales S Belongs to the UPF0125 (RnfH) family - - - ko:K09801 - - - - ko00000 - - - Ub-RnfH k59_513580_2 1479235.KK366039_gene2597 2.68e-20 85.9 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria,1XJXJ@135619|Oceanospirillales 135619|Oceanospirillales I Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc k59_1133533_2 570967.JMLV01000006_gene257 2.98e-22 87.8 COG3360@1|root,COG3360@2|Bacteria,1N6YT@1224|Proteobacteria,2UKPX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Dodecin - - - ko:K09165 - - - - ko00000 - - - Dodecin k59_455713_1 1519464.HY22_01960 4.41e-29 120.0 COG1404@1|root,COG1404@2|Bacteria,1FEZ9@1090|Chlorobi 1090|Chlorobi O Subtilase family - - - - - - - - - - - - Peptidase_S8 k59_1449252_1 436308.Nmar_1054 1.53e-42 154.0 COG1855@1|root,arCOG04116@2157|Archaea,41SX0@651137|Thaumarchaeota 651137|Thaumarchaeota S Large family of predicted nucleotide-binding domains - - - ko:K06865 - - - - ko00000 - - - KH_1,T2SSE k59_1449252_2 1229909.NSED_06160 1.73e-49 160.0 COG1321@1|root,arCOG02100@2157|Archaea,41SQ9@651137|Thaumarchaeota 651137|Thaumarchaeota K iron dependent repressor - - - - - - - - - - - - Fe_dep_repr_C,Fe_dep_repress k59_973621_1 1229909.NSED_09485 4.99e-08 53.1 arCOG08811@1|root,arCOG08811@2157|Archaea,41T85@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_973621_2 436308.Nmar_1771 3.96e-42 150.0 COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM glutamine synthetase, type I - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_1660328_1 404380.Gbem_3646 2.98e-06 48.5 COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,42MJ2@68525|delta/epsilon subdivisions,2WJQB@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0072 IF-2B k59_1660328_2 589865.DaAHT2_0522 2.75e-40 148.0 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,42NSS@68525|delta/epsilon subdivisions,2WIVV@28221|Deltaproteobacteria,2MHQ2@213118|Desulfobacterales 28221|Deltaproteobacteria J Methylates ribosomal protein L11 prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_350061_1 1400525.JNIU01000001_gene649 4e-11 62.8 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TTWE@28211|Alphaproteobacteria,4BRDN@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Glutamine synthetase, type III glnT - 6.3.1.2,6.3.4.12 ko:K01915,ko:K01949 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_350061_2 1150469.RSPPHO_02179 1.44e-27 114.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,2JR1M@204441|Rhodospirillales 204441|Rhodospirillales E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - 1.3.1.1 ko:K17722 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046 R00977,R01414,R11026 RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,NADH_4Fe-4S,Pyr_redox_2 k59_1299440_1 582744.Msip34_0660 6.02e-111 335.0 COG0260@1|root,COG0260@2|Bacteria,1MXP6@1224|Proteobacteria,2VJ0K@28216|Betaproteobacteria,2KKKC@206350|Nitrosomonadales 206350|Nitrosomonadales E Belongs to the peptidase M17 family - - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17 k59_672471_1 105420.BBPO01000013_gene5939 9.21e-77 239.0 COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria,2NGPN@228398|Streptacidiphilus 201174|Actinobacteria C Luciferase-like monooxygenase mer GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - - - - - - - - - - Bac_luciferase k59_869694_1 1210884.HG799468_gene13759 1.65e-64 222.0 COG1009@1|root,COG1009@2|Bacteria,2IX10@203682|Planctomycetes 203682|Planctomycetes CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_1660333_1 981336.F944_02281 2.97e-142 413.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,3NJAP@468|Moraxellaceae 1236|Gammaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1660333_2 580327.Tthe_1231 3.12e-51 171.0 COG0159@1|root,COG0159@2|Bacteria,1TPXA@1239|Firmicutes,248M2@186801|Clostridia,42FKM@68295|Thermoanaerobacterales 186801|Clostridia E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_185642_1 1026882.MAMP_02151 2.21e-82 249.0 COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,1T06D@1236|Gammaproteobacteria,460MN@72273|Thiotrichales 72273|Thiotrichales S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_455735_2 1219076.N646_2307 6.89e-06 48.5 2E42P@1|root,32YZ5@2|Bacteria,1N868@1224|Proteobacteria,1TAFS@1236|Gammaproteobacteria,1XUT4@135623|Vibrionales 135623|Vibrionales S Domain of unknown function (DUF4124) VP0120 - - - - - - - - - - - DUF4124 k59_1241865_2 1121381.JNIV01000089_gene323 1.08e-05 49.3 COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,1WIMD@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin moaD - 2.8.1.12 ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE,ThiS k59_1390721_1 555088.DealDRAFT_0038 1.49e-13 70.5 COG1163@1|root,COG1163@2|Bacteria,1TSAP@1239|Firmicutes,24EEW@186801|Clostridia 186801|Clostridia S GTP-binding protein HSR1-related - - - ko:K06944 - - - - ko00000 - - - MMR_HSR1,TGS k59_1390721_2 999419.HMPREF1077_00376 2.37e-09 59.3 COG0017@1|root,COG0017@2|Bacteria,4NDY4@976|Bacteroidetes,2FKYI@200643|Bacteroidia,22XA5@171551|Porphyromonadaceae 976|Bacteroidetes J Asparaginyl-tRNA synthetase asnS - 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_185646_1 214092.YPO2695 5.25e-25 107.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,41EP6@629|Yersinia 1236|Gammaproteobacteria L Belongs to the DNA photolyase family phrB GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0006139,GO:0006259,GO:0006281,GO:0006464,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0018298,GO:0019538,GO:0033554,GO:0034641,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901564 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_513654_1 1121930.AQXG01000009_gene278 5.37e-10 62.4 COG0517@1|root,COG0517@2|Bacteria,4NGW0@976|Bacteroidetes,1IV0R@117747|Sphingobacteriia 976|Bacteroidetes S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS,GCS2 k59_1179089_1 436308.Nmar_1054 6.91e-128 381.0 COG1855@1|root,arCOG04116@2157|Archaea,41SX0@651137|Thaumarchaeota 651137|Thaumarchaeota S Large family of predicted nucleotide-binding domains - - - ko:K06865 - - - - ko00000 - - - KH_1,T2SSE k59_400729_1 1122621.ATZA01000012_gene3157 1.3e-62 216.0 COG0308@1|root,COG0308@2|Bacteria,4NF3R@976|Bacteroidetes,1IPQP@117747|Sphingobacteriia 976|Bacteroidetes E Peptidase family M1 domain - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_4,ABC2_membrane_5,Peptidase_M1 k59_1133595_2 1232410.KI421412_gene169 1.13e-18 84.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NQ1@68525|delta/epsilon subdivisions,2X5KW@28221|Deltaproteobacteria,43SYA@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_1241884_1 745411.B3C1_11434 4.1e-57 199.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,1J5BG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1540516_1 1131266.ARWQ01000005_gene851 1.88e-44 157.0 COG0351@1|root,arCOG00020@2157|Archaea,41SA1@651137|Thaumarchaeota 651137|Thaumarchaeota H Phosphomethylpyrimidine kinase - - 2.5.1.3,2.7.1.49,2.7.4.7 ko:K21219 ko00730,ko01100,map00730,map01100 - R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko01000 - - - Phos_pyr_kin,ThiP_synth k59_764631_1 1123279.ATUS01000007_gene3076 1.06e-90 297.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1J52Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_243058_1 998674.ATTE01000001_gene425 1.49e-101 306.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,45ZZ4@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_1299503_1 671143.DAMO_3124 5.4e-19 92.4 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA,PAS,SpoIIE,sCache_3_2 k59_1081608_1 745310.G432_15905 1.87e-34 132.0 COG1960@1|root,COG1960@2|Bacteria,1PRJJ@1224|Proteobacteria,2UQWF@28211|Alphaproteobacteria,2K1XZ@204457|Sphingomonadales 204457|Sphingomonadales I Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_1600141_1 204773.HEAR1679 1.66e-91 278.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VH51@28216|Betaproteobacteria,472AF@75682|Oxalobacteraceae 28216|Betaproteobacteria O Peptidase family U32 yhbU - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_297991_1 1120985.AUMI01000014_gene969 2.5e-53 187.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,4H28C@909932|Negativicutes 909932|Negativicutes L ATP-dependent DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1179112_1 298653.Franean1_1077 1.21e-80 269.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,2GM65@201174|Actinobacteria,4ERFQ@85013|Frankiales 201174|Actinobacteria EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016853,GO:0016866,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0047727,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 5.4.99.13,5.4.99.2 ko:K01848,ko:K11942 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_455782_1 870967.VIS19158_02350 9.38e-73 243.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,1XTUF@135623|Vibrionales 135623|Vibrionales S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_243081_1 762376.AXYL_02811 2.03e-18 89.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2VHJR@28216|Betaproteobacteria,3T1CS@506|Alcaligenaceae 28216|Betaproteobacteria I Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_513727_1 1236959.BAMT01000017_gene2378 1.65e-38 143.0 COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,2VMG1@28216|Betaproteobacteria,2KKJE@206350|Nitrosomonadales 206350|Nitrosomonadales H HemX, putative uroporphyrinogen-III C-methyltransferase - - 2.1.1.107 ko:K02496 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000 - - - HemX k59_1335320_1 1286106.MPL1_04907 2.44e-24 107.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,45ZRN@72273|Thiotrichales 72273|Thiotrichales O Peptidylprolyl isomerase - - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_1299538_1 318167.Sfri_1237 2.38e-45 167.0 COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria 1236|Gammaproteobacteria U COG0823 Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - PD40 k59_829714_2 379731.PST_0556 2.82e-33 120.0 COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,1S6VJ@1236|Gammaproteobacteria,1Z0X1@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria NU pilus assembly protein PilP pilP - - ko:K02665 - - - - ko00000,ko02035,ko02044 - - - PilP k59_672578_1 436308.Nmar_1709 7.83e-69 226.0 COG0661@1|root,arCOG01189@2157|Archaea,41SYQ@651137|Thaumarchaeota 651137|Thaumarchaeota S ABC1 family - - - - - - - - - - - - ABC1 k59_672581_1 879212.DespoDRAFT_00688 2.4e-59 210.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales 28221|Deltaproteobacteria M TIGRFAM penicillin-binding protein, 1A family mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_401725_1 1122222.AXWR01000027_gene235 2.18e-44 155.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1WIP8@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_1243021_1 502025.Hoch_3584 7.91e-61 201.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2YYIW@29|Myxococcales 28221|Deltaproteobacteria H Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_299201_1 215803.DB30_5121 1.71e-21 94.7 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,42YFS@68525|delta/epsilon subdivisions,2WUBM@28221|Deltaproteobacteria,2YU6D@29|Myxococcales 28221|Deltaproteobacteria C Iron-containing alcohol dehydrogenase - - - - - - - - - - - - Fe-ADH k59_1541535_1 330214.NIDE0516 4.66e-44 156.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding hcf136 - - - - - - - - - - - BNR,Sortilin-Vps10 k59_974869_1 1449063.JMLS01000001_gene4191 7.79e-15 81.3 COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,4HB2V@91061|Bacilli,26SFU@186822|Paenibacillaceae 91061|Bacilli G Alpha-mannosidase - - - - - - - - - - - - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C k59_557239_1 710685.MycrhN_6251 9.99e-45 156.0 COG1028@1|root,COG1028@2|Bacteria,2ID9A@201174|Actinobacteria,23803@1762|Mycobacteriaceae 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_608745_1 314285.KT71_18736 0.000178 50.8 COG1404@1|root,COG1520@1|root,COG3209@1|root,COG3291@1|root,COG3391@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria 1236|Gammaproteobacteria M rhs family - - - - - - - - - - - - RHS_repeat k59_1662071_1 648996.Theam_0099 9.96e-24 99.0 COG1926@1|root,COG1926@2|Bacteria,2G4JX@200783|Aquificae 200783|Aquificae S Phosphoribosyl transferase domain - - - - - - - - - - - - Pribosyltran k59_831375_1 237368.SCABRO_03323 6.06e-73 245.0 COG3264@1|root,COG3264@2|Bacteria,2IY5W@203682|Planctomycetes 203682|Planctomycetes M COG3264 Small-conductance mechanosensitive channel - - - ko:K22051 - - - - ko00000,ko02000 1.A.23.1.2,1.A.23.1.3 - - MS_channel k59_1180109_1 391598.FBBAL38_02465 1.05e-65 218.0 COG1696@1|root,COG1696@2|Bacteria,4NFK5@976|Bacteroidetes,1HWM1@117743|Flavobacteriia 976|Bacteroidetes M Membrane protein involved in D-alanine export - - - - - - - - - - - - MBOAT k59_870945_1 497964.CfE428DRAFT_2707 1.86e-106 322.0 COG3696@1|root,COG3696@2|Bacteria,46SJ1@74201|Verrucomicrobia 74201|Verrucomicrobia P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cusA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_716374_1 521000.PROVRETT_07564 2.42e-73 231.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,3Z8P9@586|Providencia 1236|Gammaproteobacteria H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC GO:0003674,GO:0003824,GO:0004592,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_0142,iECSP_1301.ECSP_0134,iECs_1301.ECs0137,iG2583_1286.G2583_0137,iZ_1308.Z0144 Pantoate_ligase k59_716374_2 290318.Cvib_0725 7.15e-13 68.6 COG0413@1|root,COG0413@2|Bacteria,1FDQ8@1090|Chlorobi 1090|Chlorobi H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_1662094_1 130081.XP_005708262.1 7.04e-08 55.8 COG0572@1|root,KOG4203@2759|Eukaryota 2759|Eukaryota F UMP salvage - GO:0003674,GO:0003824,GO:0004845,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006109,GO:0006139,GO:0006206,GO:0006207,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009507,GO:0009536,GO:0009889,GO:0009987,GO:0010138,GO:0010556,GO:0010675,GO:0010962,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016763,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0031323,GO:0031326,GO:0032262,GO:0032881,GO:0032885,GO:0032950,GO:0032951,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043173,GO:0043174,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043255,GO:0043455,GO:0044206,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046112,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:1900376,GO:1901135,GO:1901137,GO:1901141,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:2000112,GO:2000762,GO:2000904,GO:2001006 2.4.2.9,2.7.1.48,5.1.3.1 ko:K00761,ko:K00876,ko:K01783 ko00030,ko00040,ko00240,ko00710,ko00983,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00240,map00710,map00983,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R00513,R00516,R00517,R00962,R00964,R00966,R00967,R00968,R00970,R01529,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017,RC00063,RC00540 ko00000,ko00001,ko00002,ko01000 - - - PRK,UPRTase k59_1450343_1 216594.MMAR_4042 3.83e-38 135.0 COG2123@1|root,COG2123@2|Bacteria,2I466@201174|Actinobacteria,2342B@1762|Mycobacteriaceae 201174|Actinobacteria J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_1450343_2 1107311.Q767_03270 0.000281 44.3 COG0860@1|root,COG0860@2|Bacteria,4NGKC@976|Bacteroidetes,1HX7G@117743|Flavobacteriia,2NTX6@237|Flavobacterium 976|Bacteroidetes M Ami_3 amiA - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 k59_1391797_1 1121015.N789_03360 1.33e-06 50.4 COG0515@1|root,COG0515@2|Bacteria,1QXK0@1224|Proteobacteria,1T3DE@1236|Gammaproteobacteria 1236|Gammaproteobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K11912 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - Pkinase,TIR_2 k59_1399874_1 1121445.ATUZ01000017_gene2002 5.79e-43 168.0 COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,42M49@68525|delta/epsilon subdivisions,2WJ5G@28221|Deltaproteobacteria,2M8QA@213115|Desulfovibrionales 28221|Deltaproteobacteria J elongation factor SelB, winged helix selB - - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 k59_1251390_1 643867.Ftrac_0442 1.44e-10 70.1 COG0739@1|root,COG0860@1|root,COG4219@1|root,COG0739@2|Bacteria,COG0860@2|Bacteria,COG4219@2|Bacteria,4NGHH@976|Bacteroidetes,47NA5@768503|Cytophagia 976|Bacteroidetes M PFAM Peptidase family M23 - - - - - - - - - - - - Peptidase_M23,Peptidase_M56 k59_1251391_2 1430440.MGMSRv2_1739 1.04e-100 300.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria,2JQ9E@204441|Rhodospirillales 204441|Rhodospirillales Q ABC transporter, ATP-binding protein - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_724783_1 330214.NIDE4113 8.23e-97 290.0 COG0498@1|root,COG0498@2|Bacteria,3J0FI@40117|Nitrospirae 40117|Nitrospirae E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine thrC2 - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_252746_1 876269.ARWA01000001_gene1628 3.2e-23 99.4 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria,3NAPY@45404|Beijerinckiaceae 28211|Alphaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family udg - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_252746_2 330214.NIDE4146 2.68e-13 70.9 COG1413@1|root,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity - - - - - - - - - - - - HEAT_2,HEAT_PBS k59_618280_1 1121413.JMKT01000011_gene2301 1.43e-15 74.3 2E20Q@1|root,32X8P@2|Bacteria,1N3P4@1224|Proteobacteria,42TSV@68525|delta/epsilon subdivisions,2WQ7Q@28221|Deltaproteobacteria,2MCZ9@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_981964_1 445686.E3SKU6_9CAUD 1.64e-13 75.5 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_1399900_1 159749.E7BWK0 2.3e-182 531.0 COG0653@1|root,2QS7I@2759|Eukaryota,2XADP@2836|Bacillariophyta 2759|Eukaryota U Protein translocase subunit secA secA - - - - - - - - - - - SecA_DEAD,SecA_PP_bind,SecA_SW k59_1399900_2 203124.Tery_4707 3.83e-05 43.1 COG0230@1|root,COG0230@2|Bacteria,1GAG5@1117|Cyanobacteria,1HDKH@1150|Oscillatoriales 1117|Cyanobacteria J Belongs to the bacterial ribosomal protein bL34 family rpmH - - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 k59_1188213_1 237727.NAP1_11598 1.39e-09 63.2 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2K18E@204457|Sphingomonadales 204457|Sphingomonadales CG Dehydrogenase - - 1.1.9.1 ko:K17760 - - - - ko00000,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_1550877_2 1123060.JONP01000016_gene5523 1.35e-41 140.0 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2U982@28211|Alphaproteobacteria,2JSWP@204441|Rhodospirillales 204441|Rhodospirillales S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_618332_1 479433.Caci_8225 1.62e-13 70.1 COG1309@1|root,COG1309@2|Bacteria,2IIIS@201174|Actinobacteria 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_618332_2 1123261.AXDW01000011_gene643 1.09e-23 102.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,1X4FN@135614|Xanthomonadales 135614|Xanthomonadales G Glucose dehydrogenase gcd2 - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 k59_724823_1 502025.Hoch_0520 3.01e-44 156.0 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,43418@68525|delta/epsilon subdivisions,2X2J1@28221|Deltaproteobacteria,2Z08E@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_879306_1 1116472.MGMO_150c00070 4.51e-87 271.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,1XG55@135618|Methylococcales 135618|Methylococcales H Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone - - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_879306_2 671143.DAMO_0485 1.23e-16 78.6 COG0363@1|root,COG0363@2|Bacteria,2NPBM@2323|unclassified Bacteria 2|Bacteria G Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase pgl - 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_1251462_1 1267535.KB906767_gene75 1.29e-55 189.0 COG1181@1|root,COG1181@2|Bacteria,3Y7GI@57723|Acidobacteria 57723|Acidobacteria M ATP-grasp domain - - - - - - - - - - - - ATP-grasp_4 k59_196306_1 1173024.KI912148_gene3732 1.73e-32 127.0 COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria 1117|Cyanobacteria V ABC-type transport system involved in lipoprotein release permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_411344_1 246197.MXAN_2148 1.94e-67 228.0 COG1643@1|root,COG1643@2|Bacteria 2|Bacteria L helicase activity - - 3.6.4.13 ko:K03578,ko:K03579 - - - - ko00000,ko01000 - - - AAA_11,AAA_12,DEAD,DUF3418,DUF4011,HA2,Helicase_C k59_935433_1 1108045.GORHZ_056_00010 4.64e-65 211.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,4GCSE@85026|Gordoniaceae 201174|Actinobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_28,HTH_32 k59_724830_1 572546.Arcpr_1296 6.56e-07 52.4 COG1475@1|root,arCOG00622@2157|Archaea,2XTYJ@28890|Euryarchaeota,245XD@183980|Archaeoglobi 183980|Archaeoglobi K PFAM CBS domain - - - - - - - - - - - - CBS,ParBc k59_724830_2 1479237.JMLY01000001_gene3066 1.84e-08 54.3 2EHHF@1|root,33B9C@2|Bacteria,1NM2H@1224|Proteobacteria,1STI2@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_360202_1 269799.Gmet_2410 1e-67 209.0 COG0605@1|root,COG0605@2|Bacteria,1R4Z3@1224|Proteobacteria,42QV7@68525|delta/epsilon subdivisions,2WMPC@28221|Deltaproteobacteria,43VQC@69541|Desulfuromonadales 28221|Deltaproteobacteria C Iron/manganese superoxide dismutases, C-terminal domain sodA - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_1251485_1 1458427.BAWN01000008_gene525 5.63e-84 262.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2VI2T@28216|Betaproteobacteria,4AABF@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_1035749_1 331678.Cphamn1_1569 8.47e-63 204.0 COG0111@1|root,COG0111@2|Bacteria 2|Bacteria EH 4-phosphoerythronate dehydrogenase activity serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_1035749_2 1121939.L861_18145 2.84e-13 68.9 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1XIJ6@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_982030_1 1313172.YM304_41440 3.67e-35 130.0 COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4CNYR@84992|Acidimicrobiia 84992|Acidimicrobiia S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1607429_1 1392838.AWNM01000042_gene1545 2.27e-131 392.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,3T2WG@506|Alcaligenaceae 28216|Betaproteobacteria O ABC transporter atm1 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_252810_1 1410619.SRDD_32700 1.48e-30 115.0 COG0625@1|root,COG0625@2|Bacteria,1RA4M@1224|Proteobacteria,1S2K3@1236|Gammaproteobacteria,402KN@613|Serratia 1236|Gammaproteobacteria O Glutathione S-transferase yliJ GO:0003674,GO:0003824,GO:0004364,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016740,GO:0016765,GO:0030611,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_252810_2 224324.aq_2197 2.54e-47 160.0 COG3063@1|root,COG3063@2|Bacteria 2|Bacteria NU photosynthesis sscB - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_1344512_1 553175.POREN0001_1190 6.12e-64 208.0 COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes,2FM0N@200643|Bacteroidia,22W8W@171551|Porphyromonadaceae 976|Bacteroidetes E 2-amino-3-ketobutyrate CoA ligase bioF - 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1035754_1 1168034.FH5T_10085 9.86e-25 96.7 2CCSR@1|root,32RSC@2|Bacteria,4NT8X@976|Bacteroidetes 976|Bacteroidetes S 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_1035754_2 1121859.KB890739_gene2807 2.47e-05 46.6 COG0644@1|root,COG0644@2|Bacteria,4PKHH@976|Bacteroidetes,47Y7I@768503|Cytophagia 976|Bacteroidetes C Glucose inhibited division protein A - - - - - - - - - - - - FAD_oxidored k59_879338_1 1122951.ATUE01000006_gene1325 1.46e-55 194.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,3NJ8A@468|Moraxellaceae 1236|Gammaproteobacteria E B12 binding domain metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545 B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_879338_2 1229780.BN381_10085 9.81e-08 57.0 COG1011@1|root,COG1011@2|Bacteria,2HP8I@201174|Actinobacteria,3UWYW@52018|unclassified Actinobacteria (class) 201174|Actinobacteria S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_411385_1 1163617.SCD_n01730 1.66e-90 285.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJI0@28216|Betaproteobacteria 28216|Betaproteobacteria P von Willebrand factor (vWF) type A domain - - - ko:K02448 - - R00294 RC02794 ko00000 3.D.4.10 - - VWA_2 k59_308322_1 314345.SPV1_10616 3.13e-40 144.0 COG1752@1|root,COG1752@2|Bacteria,1RCDG@1224|Proteobacteria 1224|Proteobacteria S Esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_565713_1 1120999.JONM01000003_gene2764 0.000869 50.1 COG3250@1|root,COG3250@2|Bacteria,1NKPN@1224|Proteobacteria,2VTD6@28216|Betaproteobacteria 28216|Betaproteobacteria G Immunoglobulin - - - - - - - - - - - - I-set k59_1035771_1 759914.BP951000_1076 5.34e-11 70.1 COG0392@1|root,COG0392@2|Bacteria 2|Bacteria M lysyltransferase activity mprF - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_1607450_1 436308.Nmar_0394 5.21e-116 334.0 COG0605@1|root,arCOG04147@2157|Archaea,41S6C@651137|Thaumarchaeota 651137|Thaumarchaeota P Destroys radicals which are normally produced within the cells and which are toxic to biological systems - - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_308327_1 767434.Fraau_2389 5.66e-58 199.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1X3CX@135614|Xanthomonadales 135614|Xanthomonadales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1036750_3 1123368.AUIS01000004_gene216 1.76e-28 107.0 COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,1S5YH@1236|Gammaproteobacteria,2NCUB@225057|Acidithiobacillales 225057|Acidithiobacillales H MoaE protein - - 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE k59_983372_1 1403819.BATR01000033_gene1100 2.52e-29 120.0 COG0405@1|root,COG0405@2|Bacteria,46SGY@74201|Verrucomicrobia,2IVID@203494|Verrucomicrobiae 203494|Verrucomicrobiae E Gamma-glutamyltranspeptidase - - - - - - - - - - - - G_glu_transpept k59_412654_1 290397.Adeh_1839 5.68e-46 169.0 COG3378@1|root,COG4983@1|root,COG3378@2|Bacteria,COG4983@2|Bacteria,1PDTD@1224|Proteobacteria,42TSY@68525|delta/epsilon subdivisions,2WV92@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Phage plasmid primase P4 family - - - - - - - - - - - - - k59_1252773_1 882082.SaccyDRAFT_2781 8.27e-66 214.0 COG0121@1|root,COG0121@2|Bacteria 2|Bacteria S cellular modified histidine biosynthetic process - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - - - - - - - - - - NAD_binding_8,PI-PLC-C1 k59_309591_2 1278073.MYSTI_01963 4.84e-48 174.0 COG0749@1|root,COG0749@2|Bacteria,1MWX7@1224|Proteobacteria 1224|Proteobacteria L COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A,DNA_pol_A_exo1 k59_1459800_1 156889.Mmc1_0360 1.68e-101 311.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2TQWH@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_197727_1 1132442.KB889752_gene788 1.01e-08 55.5 COG0528@1|root,COG0528@2|Bacteria,1TPXN@1239|Firmicutes,4H9UB@91061|Bacilli,1ZBMW@1386|Bacillus 91061|Bacilli F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - iSB619.SA_RS06240 AA_kinase k59_197727_2 1216932.CM240_1717 1.26e-32 124.0 COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,36DEJ@31979|Clostridiaceae 186801|Clostridia J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_1252798_1 349124.Hhal_1652 2e-105 317.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1WW7C@135613|Chromatiales 135613|Chromatiales E Belongs to the aspartokinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_619766_1 1430440.MGMSRv2_1061 3.93e-28 115.0 COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2TSQ2@28211|Alphaproteobacteria,2JRD2@204441|Rhodospirillales 204441|Rhodospirillales P protein involved in response to NO - - - ko:K07234 - - - - ko00000 - - - NnrS k59_467132_1 634497.HAH_2068 2.98e-12 75.9 COG0642@1|root,COG2203@1|root,arCOG02388@2157|Archaea,arCOG06192@2157|Archaea,2Y7S4@28890|Euryarchaeota,240W2@183963|Halobacteria 183963|Halobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - GAF_2,HATPase_c,PAS,PAS_4,PAS_9,Response_reg k59_1189619_1 237368.SCABRO_01998 4.19e-52 182.0 COG1008@1|root,COG1008@2|Bacteria,2IX79@203682|Planctomycetes 203682|Planctomycetes C proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_936744_1 1123279.ATUS01000001_gene1876 5.88e-35 127.0 COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,1J61K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG3166 Tfp pilus assembly protein PilN pilN - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_1401233_1 483219.LILAB_15790 4.87e-36 135.0 COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,42U5W@68525|delta/epsilon subdivisions,2WQUQ@28221|Deltaproteobacteria,2YX8E@29|Myxococcales 28221|Deltaproteobacteria L Transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,Nterm_IS4 k59_1345843_2 330214.NIDE4022 3.42e-79 237.0 COG0633@1|root,COG0633@2|Bacteria,3J1AM@40117|Nitrospirae 40117|Nitrospirae C 2Fe-2S iron-sulfur cluster binding domain - - - ko:K04755 - - - - ko00000 - - - Fer2 k59_1189624_1 187272.Mlg_0246 9.89e-105 325.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,1WVWD@135613|Chromatiales 135613|Chromatiales C PFAM malic - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_1189624_2 400668.Mmwyl1_3771 1.4e-76 243.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1XIPR@135619|Oceanospirillales 135619|Oceanospirillales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_1552230_2 439235.Dalk_3108 2.41e-36 132.0 COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,43BDR@68525|delta/epsilon subdivisions,2X6SB@28221|Deltaproteobacteria,2MPIC@213118|Desulfobacterales 28221|Deltaproteobacteria C TIGRFAM SagB-type dehydrogenase domain - - - - - - - - - - - - Nitroreductase k59_774990_1 1370121.AUWS01000083_gene4744 1.92e-47 157.0 COG0346@1|root,COG0346@2|Bacteria,2IFZW@201174|Actinobacteria,2390W@1762|Mycobacteriaceae 201174|Actinobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase_4 k59_774990_2 990073.ATHU01000001_gene1325 2.52e-10 65.1 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2YMN0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ reductase fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_21397_1 68570.DC74_1835 7.93e-77 241.0 COG2141@1|root,COG2141@2|Bacteria,2GKP1@201174|Actinobacteria 201174|Actinobacteria C Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_361460_1 497965.Cyan7822_5396 2.8e-05 47.8 COG1235@1|root,COG1235@2|Bacteria,1G1UR@1117|Cyanobacteria,3KG63@43988|Cyanothece 1117|Cyanobacteria S beta-lactamase domain protein - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_253894_2 981383.AEWH01000004_gene3381 9.93e-05 48.5 COG0835@1|root,COG0835@2|Bacteria,1V4HH@1239|Firmicutes,4HHB5@91061|Bacilli 91061|Bacilli NT Chemotaxis protein cheW cheW GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006935,GO:0008150,GO:0009453,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0042333,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_253894_3 395493.BegalDRAFT_2973 9.74e-29 106.0 COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,1S5UT@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Response regulator receiver - - - ko:K02658 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_412730_1 1267534.KB906756_gene219 3.42e-17 85.9 COG0308@1|root,COG0457@1|root,COG0308@2|Bacteria,COG0457@2|Bacteria,3Y3C5@57723|Acidobacteria,2JI5M@204432|Acidobacteriia 204432|Acidobacteriia E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1,TPR_11,TPR_16 k59_309648_2 264462.Bd1201 2.05e-79 251.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42M0R@68525|delta/epsilon subdivisions,2MSUE@213481|Bdellovibrionales,2WJE6@28221|Deltaproteobacteria 213481|Bdellovibrionales C PFAM acyl-CoA dehydrogenase domain protein - - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1345869_1 330214.NIDE3224 2.42e-36 125.0 COG3071@1|root,COG3071@2|Bacteria 2|Bacteria H HemY protein hemY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02498 - - - - ko00000 - - - HemY_N,TPR_2 k59_1568485_2 436308.Nmar_0009 7.22e-44 148.0 arCOG01806@1|root,arCOG01806@2157|Archaea,41T2B@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_837480_1 396588.Tgr7_3303 7.23e-55 190.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1WWG8@135613|Chromatiales 135613|Chromatiales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_889834_2 1123401.JHYQ01000018_gene2373 5.51e-50 172.0 COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,1RPYD@1236|Gammaproteobacteria,45ZVB@72273|Thiotrichales 72273|Thiotrichales S Bacterial protein of unknown function (DUF853) - - - ko:K06915 - - - - ko00000 - - - DUF853 k59_785578_1 309799.DICTH_0487 4.3e-07 57.0 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_3 k59_1621067_1 1169152.AXVD01000014_gene1448 1.91e-80 248.0 COG4689@1|root,COG4689@2|Bacteria,2GJWN@201174|Actinobacteria,4FXHE@85025|Nocardiaceae 201174|Actinobacteria Q Acetoacetate decarboxylase (ADC) - - - - - - - - - - - - ADC k59_419565_1 1492737.FEM08_22930 1.78e-27 112.0 COG0520@1|root,COG0520@2|Bacteria,4NDUB@976|Bacteroidetes,1HWSI@117743|Flavobacteriia,2NV7R@237|Flavobacterium 976|Bacteroidetes E Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_419565_2 765911.Thivi_1085 3.56e-17 81.6 COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1WWK5@135613|Chromatiales 135613|Chromatiales O FeS assembly protein SufD - - - ko:K09015 - - - - ko00000 - - - UPF0051 k59_889839_2 398767.Glov_1284 3.43e-14 67.4 COG1826@1|root,COG1826@2|Bacteria,1NI3F@1224|Proteobacteria,42VIZ@68525|delta/epsilon subdivisions,2WRC5@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatB - - ko:K03116,ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_471482_1 331869.BAL199_16808 6.05e-30 107.0 COG3492@1|root,COG3492@2|Bacteria,1MZ3I@1224|Proteobacteria,2UC11@28211|Alphaproteobacteria,4BQI0@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1244) MA20_03865 - - ko:K09948 - - - - ko00000 - - - DUF1244 k59_471482_2 1120999.JONM01000002_gene896 4.71e-26 109.0 COG3735@1|root,COG3735@2|Bacteria,1Q121@1224|Proteobacteria,2VT43@28216|Betaproteobacteria,2KRFK@206351|Neisseriales 206351|Neisseriales S TraB family - - - ko:K09973 - - - - ko00000 - - - TraB k59_628960_1 693444.D782_4545 3.98e-35 131.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,28305@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_471487_2 177439.DP0203 5.56e-37 131.0 COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,42T5M@68525|delta/epsilon subdivisions,2WQZ1@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_733084_1 768671.ThimaDRAFT_2294 8.61e-52 179.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,1WW5Y@135613|Chromatiales 135613|Chromatiales EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_837500_1 1269813.ATUL01000031_gene1391 1.21e-13 66.2 COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,1WYGS@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H k59_837500_2 396588.Tgr7_0454 4.98e-17 80.9 COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,1RP55@1236|Gammaproteobacteria,1WWS0@135613|Chromatiales 135613|Chromatiales P inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_54366_1 478741.JAFS01000002_gene995 2.52e-21 91.3 COG1432@1|root,COG1432@2|Bacteria,46SBH@74201|Verrucomicrobia 74201|Verrucomicrobia S NYN domain - - - - - - - - - - - - NYN,OST-HTH k59_1359961_1 34506.g2494 9.53e-55 193.0 COG5641@1|root,KOG1601@2759|Eukaryota,3AI5I@33154|Opisthokonta,3BXPT@33208|Metazoa,3DD4K@33213|Bilateria,40RIE@6231|Nematoda,1M8NK@119089|Chromadorea,416VV@6236|Rhabditida 33208|Metazoa T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1255650_2 1207076.ALAT01000184_gene2654 6.96e-84 254.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1Z05X@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily rpoE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0006950,GO:0006970,GO:0008150,GO:0009266,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_993845_1 323261.Noc_0758 6.64e-24 106.0 COG3166@1|root,COG4972@1|root,COG3166@2|Bacteria,COG4972@2|Bacteria,1RJTG@1224|Proteobacteria,1S6RT@1236|Gammaproteobacteria,1WXKF@135613|Chromatiales 135613|Chromatiales NU fimbrial assembly - - - ko:K02461 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - PilM_2,PilN k59_54376_1 929703.KE386491_gene2820 7.07e-44 164.0 COG1404@1|root,COG1404@2|Bacteria,4PM4C@976|Bacteroidetes,47KZM@768503|Cytophagia 976|Bacteroidetes O Subtilase family - - - - - - - - - - - - PKD,Peptidase_S8,fn3 k59_1359969_1 667632.KB890209_gene5505 1.33e-20 95.9 COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2VNCK@28216|Betaproteobacteria,1K35S@119060|Burkholderiaceae 28216|Betaproteobacteria S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - 3.4.14.11 ko:K01281,ko:K06978 - - - - ko00000,ko01000,ko01002 - - - PepX_C,Peptidase_S15 k59_1046468_1 243233.MCA2384 3.8e-70 226.0 COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,1XECA@135618|Methylococcales 135618|Methylococcales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway nqrF - 1.6.5.8 ko:K00351 - - - - ko00000,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_105892_1 1095769.CAHF01000025_gene648 1.43e-89 268.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,472G3@75682|Oxalobacteraceae 28216|Betaproteobacteria O Belongs to the GST superfamily - - 2.5.1.18 ko:K00799,ko:K11209 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N k59_838343_2 1123401.JHYQ01000002_gene2757 1.02e-46 164.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,45ZVD@72273|Thiotrichales 72273|Thiotrichales E TIGRFAM Acetolactate synthase, large subunit, biosynthetic - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_55372_1 880072.Desac_0371 1.69e-12 69.7 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,42N2A@68525|delta/epsilon subdivisions,2WIP6@28221|Deltaproteobacteria,2MRGH@213462|Syntrophobacterales 28221|Deltaproteobacteria J tRNA synthetases class I (W and Y) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_629991_1 335543.Sfum_1145 0.000549 43.1 2CDHP@1|root,32RXU@2|Bacteria,1N1BP@1224|Proteobacteria,42TPT@68525|delta/epsilon subdivisions,2WQE6@28221|Deltaproteobacteria,2MRXY@213462|Syntrophobacterales 28221|Deltaproteobacteria S RsbT co-antagonist protein rsbRD N-terminal domain - - - - - - - - - - - - RsbRD_N k59_629991_2 1167006.UWK_00242 1.91e-73 231.0 COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,42MZU@68525|delta/epsilon subdivisions,2WKKU@28221|Deltaproteobacteria,2MI6J@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Nitrate reductase gamma subunit dsrM - 1.7.5.1 ko:K00374 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Nitrate_red_gam k59_942500_1 1380394.JADL01000016_gene409 3.5e-28 112.0 COG0697@1|root,COG0697@2|Bacteria,1MWSU@1224|Proteobacteria,2TSWT@28211|Alphaproteobacteria,2JSPC@204441|Rhodospirillales 204441|Rhodospirillales EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_368328_1 1122135.KB893135_gene689 1.22e-32 129.0 COG0121@1|root,COG1305@1|root,COG0121@2|Bacteria,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,2TTZY@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Transglutaminase - - - - - - - - - - - - Bact_transglu_N,GATase_4,Transglut_core k59_1412601_1 1313172.YM304_41440 7.1e-41 146.0 COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4CNYR@84992|Acidimicrobiia 84992|Acidimicrobiia S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1412601_2 1333998.M2A_1987 0.000149 43.9 COG1309@1|root,COG1309@2|Bacteria,1NP72@1224|Proteobacteria,2UKXU@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1308129_1 436308.Nmar_1028 1.02e-141 409.0 COG1250@1|root,arCOG00249@2157|Archaea,41S92@651137|Thaumarchaeota 651137|Thaumarchaeota I 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35,4.2.1.17 ko:K15016 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00374,M00375 R01975,R03026 RC00117,RC00831 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N k59_838360_1 1122137.AQXF01000003_gene1871 4.75e-43 154.0 COG0845@1|root,COG0845@2|Bacteria,1MV1T@1224|Proteobacteria,2VFH0@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_D23 k59_630001_1 1034769.KB910518_gene4951 1.3e-21 100.0 COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,4H9ZM@91061|Bacilli,26S70@186822|Paenibacillaceae 91061|Bacilli D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 2.4.2.8,6.3.4.19 ko:K04075,ko:K15780 ko00230,ko01100,ko01110,map00230,map01100,map01110 - R01132,R01229,R02142,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_1465320_1 861299.J421_3257 1.13e-116 352.0 COG0504@1|root,COG0504@2|Bacteria,1ZT0J@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_1516538_1 596320.NEIFL0001_0296 3.84e-36 132.0 COG3676@1|root,COG3676@2|Bacteria,1QTF7@1224|Proteobacteria,2VSUV@28216|Betaproteobacteria,2KT9U@206351|Neisseriales 206351|Neisseriales L ISXO2-like transposase domain - - - ko:K07488 - - - - ko00000 - - - DDE_Tnp_IS1595 k59_211498_1 136993.KB900627_gene71 1.43e-57 199.0 COG0653@1|root,COG0653@2|Bacteria,1MX0P@1224|Proteobacteria,2U086@28211|Alphaproteobacteria,371CY@31993|Methylocystaceae 28211|Alphaproteobacteria U SecA preprotein cross-linking domain - - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SecA_DEAD,SecA_PP_bind k59_263793_1 765911.Thivi_1869 3.41e-98 297.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1WWNU@135613|Chromatiales 135613|Chromatiales E PFAM Aminotransferase class-III argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_838363_1 765913.ThidrDRAFT_2029 6.69e-105 317.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria,1WXQI@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_8 k59_55397_1 1217718.ALOU01000050_gene3113 6.39e-57 188.0 COG0500@1|root,COG0500@2|Bacteria,1MVD1@1224|Proteobacteria,2WHP6@28216|Betaproteobacteria,1KIQU@119060|Burkholderiaceae 28216|Betaproteobacteria Q C-methyltransferase C-terminal domain - - - - - - - - - - - - Methyltransf_13,Methyltransf_14,Methyltransf_23 k59_786649_1 1004785.AMBLS11_00330 1.18e-08 54.3 COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,1SCH1@1236|Gammaproteobacteria,46899@72275|Alteromonadaceae 1236|Gammaproteobacteria S Membrane fusogenic activity yqiC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09806 - - - - ko00000 - - - BMFP k59_786649_2 395493.BegalDRAFT_2665 4.34e-09 56.6 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,4603K@72273|Thiotrichales 72273|Thiotrichales O magnesium chelatase - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_890726_1 330214.NIDE1342 1.16e-36 130.0 COG1934@1|root,COG1934@2|Bacteria,3J1EG@40117|Nitrospirae 40117|Nitrospirae S OstA-like protein - - - ko:K09774 - - - - ko00000,ko02000 1.B.42.1 - - OstA k59_472283_1 1041146.ATZB01000061_gene3108 6.78e-114 333.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,4BB9C@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_1204565_1 1192034.CAP_2498 1.16e-118 377.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,2YX1T@29|Myxococcales 28221|Deltaproteobacteria H Methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_55410_1 568706.BN118_1123 1.58e-29 119.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2VIMV@28216|Betaproteobacteria,3T78I@506|Alcaligenaceae 28216|Betaproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_1569359_2 1117943.SFHH103_02518 2.94e-05 46.2 COG0028@1|root,COG0028@2|Bacteria,1R6QP@1224|Proteobacteria,2TXAJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - - - - - - - - - - TPP_enzyme_C k59_263811_1 1187851.A33M_4209 1.64e-46 171.0 COG1013@1|root,COG1013@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor - - - - - - - - - - - - Fer4,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_577037_2 768671.ThimaDRAFT_3082 2.62e-18 83.6 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales 135613|Chromatiales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_1308155_1 1279038.KB907338_gene982 2.74e-52 185.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,2JPC0@204441|Rhodospirillales 204441|Rhodospirillales C malic enzyme dme - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_106713_1 338966.Ppro_1999 3.88e-93 285.0 COG0697@1|root,COG0697@2|Bacteria,1PIFC@1224|Proteobacteria,43A4F@68525|delta/epsilon subdivisions,2X2CE@28221|Deltaproteobacteria,43UHP@69541|Desulfuromonadales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_106713_2 1392490.JHZX01000001_gene41 4.26e-09 55.1 COG1225@1|root,COG1225@2|Bacteria,4NMX7@976|Bacteroidetes,1I1BP@117743|Flavobacteriia 976|Bacteroidetes O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA k59_786677_2 1333998.M2A_1474 8.68e-36 132.0 COG0625@1|root,COG0625@2|Bacteria,1Q1HA@1224|Proteobacteria,2UDXD@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N_3 k59_1465352_1 292415.Tbd_0532 4.72e-28 105.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2VU5H@28216|Betaproteobacteria,1KT6J@119069|Hydrogenophilales 119069|Hydrogenophilales J Sigma 54 modulation protein / S30EA ribosomal protein - - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_1465352_2 1122604.JONR01000050_gene3130 6.31e-29 111.0 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,1S668@1236|Gammaproteobacteria,1XCMT@135614|Xanthomonadales 135614|Xanthomonadales GT Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_55428_1 909663.KI867150_gene1440 1.13e-56 201.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,2MQCA@213462|Syntrophobacterales 28221|Deltaproteobacteria T Signal transduction histidine kinase phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like k59_420496_1 1177179.A11A3_10521 4.31e-33 127.0 COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,1S1Y5@1236|Gammaproteobacteria 1236|Gammaproteobacteria F P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_420496_2 1382306.JNIM01000001_gene2271 8.08e-16 80.9 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator - - - - - - - - - - - - TetR_C_6,TetR_N k59_472299_2 159450.NH14_28050 5.47e-128 385.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,1K24M@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23,OmpA k59_263826_1 1240349.ANGC01000006_gene1377 5.23e-87 268.0 COG0183@1|root,COG0183@2|Bacteria,2GKFR@201174|Actinobacteria,4G09R@85025|Nocardiaceae 201174|Actinobacteria I lipid-transfer protein - - - - - - - - - - - - Thiolase_N k59_472302_2 391165.GbCGDNIH1_1147 3.43e-05 47.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria,2JPJW@204441|Rhodospirillales 204441|Rhodospirillales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_1621940_1 1123399.AQVE01000032_gene778 2.2e-61 207.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,1RSCT@1236|Gammaproteobacteria,4624S@72273|Thiotrichales 72273|Thiotrichales C Aldehyde ferredoxin oxidoreductase, N-terminal domain - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_682295_1 1123518.ARWI01000001_gene400 3.7e-90 289.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria 1236|Gammaproteobacteria V COG0577 ABC-type antimicrobial peptide transport system permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1256759_1 911045.PSE_4273 5.64e-18 86.7 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2TQSA@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_994721_1 743719.PaelaDRAFT_3069 9.46e-38 137.0 COG1533@1|root,COG1533@2|Bacteria,1TRIS@1239|Firmicutes,4HE1C@91061|Bacilli,26RJF@186822|Paenibacillaceae 91061|Bacilli L DNA repair photolyase - - - - - - - - - - - - Radical_SAM k59_215509_1 489825.LYNGBM3L_06480 2.74e-16 82.8 COG2159@1|root,COG2159@2|Bacteria,1G3DV@1117|Cyanobacteria,1H964@1150|Oscillatoriales 1117|Cyanobacteria S TIM-barrel fold metal-dependent hydrolase - - - - - - - - - - - - Amidohydro_2 k59_894952_1 684719.HIMB114_00013450 1.01e-148 431.0 COG1840@1|root,COG1840@2|Bacteria,1MWWI@1224|Proteobacteria,2VF0S@28211|Alphaproteobacteria,4BTD5@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_6 k59_894952_2 667632.KB890165_gene2393 2.5e-43 147.0 COG0625@1|root,COG0625@2|Bacteria,1RA4M@1224|Proteobacteria,2VS6D@28216|Betaproteobacteria,1K0Y5@119060|Burkholderiaceae 28216|Betaproteobacteria O Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_1417018_1 330214.NIDE0866 5.04e-30 112.0 COG2854@1|root,COG2854@2|Bacteria,3J13Z@40117|Nitrospirae 40117|Nitrospirae Q Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_320667_1 1121374.KB891575_gene928 2.25e-171 502.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG0457 FOG TPR repeat - - - - - - - - - - - - Sulfotransfer_3,TPR_16,TPR_8 k59_3393_1 330214.NIDE3711 3.85e-76 238.0 COG0330@1|root,COG0330@2|Bacteria 2|Bacteria O stress-induced mitochondrial fusion hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_1573289_1 96561.Dole_0196 1.62e-14 73.6 COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,42NWV@68525|delta/epsilon subdivisions,2WJWC@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Nitrate reductase, beta subunit narH - 1.7.5.1 ko:K00371,ko:K17051 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8 - iAF987.Gmet_1021 Fer4_11,Nitr_red_bet_C k59_1573289_2 83406.HDN1F_20090 3.31e-82 273.0 COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,1T2GI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.7.5.1,1.8.5.3 ko:K00370,ko:K07306,ko:K17050 ko00910,ko00920,ko01120,ko02020,map00910,map00920,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497,R09501 RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.3,5.A.3.8 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_946399_1 85643.Tmz1t_1521 5.53e-15 73.6 COG3945@1|root,COG3945@2|Bacteria,1N95V@1224|Proteobacteria,2VVYB@28216|Betaproteobacteria,2KYVZ@206389|Rhodocyclales 206389|Rhodocyclales S Hemerythrin HHE cation binding - - - - - - - - - - - - Hemerythrin k59_737885_1 944481.JAFP01000001_gene796 3.82e-15 80.9 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2M6JX@213113|Desulfurellales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_1051618_1 391038.Bphy_7354 7.36e-32 114.0 COG2963@1|root,COG2963@2|Bacteria,1N8Y3@1224|Proteobacteria,2VY0M@28216|Betaproteobacteria,1KAA0@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM transposase IS3 IS911 family protein - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_1051618_2 394503.Ccel_2949 1.55e-10 60.8 COG2801@1|root,COG2801@2|Bacteria,1TQQY@1239|Firmicutes,2487W@186801|Clostridia,36W78@31979|Clostridiaceae 186801|Clostridia L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_21,rve k59_894969_1 1040986.ATYO01000003_gene5811 2.22e-71 224.0 COG3826@1|root,COG3826@2|Bacteria,1MWVV@1224|Proteobacteria,2TQMH@28211|Alphaproteobacteria,43JAE@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Oxygenase, catalysing oxidative methylation of damaged DNA MA20_16285 - - ko:K09990 - - - - ko00000 - - - Oxygenase-NA k59_529488_1 1195236.CTER_1095 2.88e-43 159.0 COG2199@1|root,COG2199@2|Bacteria,1V04Z@1239|Firmicutes,24A7E@186801|Clostridia 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_1470973_1 1408444.JHYC01000026_gene1476 3.5e-20 90.1 COG3218@1|root,COG3218@2|Bacteria,1NCG2@1224|Proteobacteria,1SCIS@1236|Gammaproteobacteria,1JCC9@118969|Legionellales 118969|Legionellales S ABC-type transport auxiliary lipoprotein component - - - ko:K18480 - M00669 - - ko00000,ko00002,ko02000 3.A.1.27.1 - - ABC_trans_aux k59_216243_1 999550.KI421507_gene2840 2.25e-17 84.3 COG3239@1|root,COG3239@2|Bacteria,1MUHK@1224|Proteobacteria,2TSTR@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Fatty acid desaturase MA20_28095 - - - - - - - - - - - FA_desaturase k59_999014_1 1254432.SCE1572_05915 4.28e-61 192.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,42QR7@68525|delta/epsilon subdivisions,2WNFM@28221|Deltaproteobacteria,2YUYC@29|Myxococcales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_216247_1 1089551.KE386572_gene3186 1.97e-45 158.0 2DBFU@1|root,2Z90B@2|Bacteria,1PI0M@1224|Proteobacteria,2U90U@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF429) - - - - - - - - - - - - DUF429 k59_216247_2 1071679.BG57_11055 6.07e-11 63.9 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VJJD@28216|Betaproteobacteria,1K1EB@119060|Burkholderiaceae 28216|Betaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_321393_3 102125.Xen7305DRAFT_00043960 5.61e-57 191.0 COG5361@1|root,COG5361@2|Bacteria,1GIK1@1117|Cyanobacteria,3VMQJ@52604|Pleurocapsales 1117|Cyanobacteria S Protein of unknown function (DUF1214) - - - - - - - - - - - - DUF1214,DUF1254 k59_999021_1 1192034.CAP_1677 5.76e-96 292.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2YYIW@29|Myxococcales 28221|Deltaproteobacteria H Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_1156401_1 1218352.B597_022050 4.74e-58 198.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,1RPU5@1236|Gammaproteobacteria,1Z0XV@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria P Anion transporter sdcS - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_529498_1 929558.SMGD1_2162 1.71e-06 56.2 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2YMW4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_895623_1 446468.Ndas_0098 2.1e-51 184.0 COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,4EHDJ@85012|Streptosporangiales 201174|Actinobacteria O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_1519778_1 439235.Dalk_3949 4.97e-59 192.0 COG0697@1|root,COG0697@2|Bacteria,1QBAD@1224|Proteobacteria,42PAK@68525|delta/epsilon subdivisions,2WKBB@28221|Deltaproteobacteria,2MJW1@213118|Desulfobacterales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_1519778_2 1191299.AJYX01000012_gene324 2.39e-35 129.0 COG1280@1|root,COG1280@2|Bacteria,1RF1D@1224|Proteobacteria,1T02Q@1236|Gammaproteobacteria,1XUXV@135623|Vibrionales 135623|Vibrionales E LysE type translocator - - - - - - - - - - - - LysE k59_1210819_1 1123322.KB904655_gene596 6.36e-48 160.0 COG2020@1|root,COG2020@2|Bacteria,2IN0C@201174|Actinobacteria 201174|Actinobacteria O Phospholipid methyltransferase - - - - - - - - - - - - PEMT k59_268690_1 330214.NIDE4083 1.04e-46 163.0 COG0671@1|root,COG0671@2|Bacteria,3J1CX@40117|Nitrospirae 40117|Nitrospirae I PAP2 superfamily - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2 k59_895629_1 1047013.AQSP01000061_gene1215 1.06e-50 169.0 COG1028@1|root,COG1028@2|Bacteria,2NRAR@2323|unclassified Bacteria 2|Bacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_1417666_1 314285.KT71_13669 8.96e-130 388.0 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - DUF3347,HlyD_D23,HlyD_D4,YtkA k59_477296_1 105559.Nwat_0710 5.9e-46 150.0 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,1WYMA@135613|Chromatiales 135613|Chromatiales O Belongs to the glutaredoxin family. Monothiol subfamily - - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin k59_477296_2 477184.KYC_07261 4.53e-16 72.0 COG5007@1|root,COG5007@2|Bacteria,1MZCZ@1224|Proteobacteria,2VU0K@28216|Betaproteobacteria,3T4IC@506|Alcaligenaceae 28216|Betaproteobacteria K Belongs to the BolA IbaG family yrbA - - - - - - - - - - - BolA k59_843228_1 448385.sce4709 4.37e-07 58.5 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,42SQR@68525|delta/epsilon subdivisions,2WUZ8@28221|Deltaproteobacteria,2YUU5@29|Myxococcales 28221|Deltaproteobacteria I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_792833_1 362418.IW19_18480 3.95e-05 52.8 COG0204@1|root,COG4258@1|root,COG0204@2|Bacteria,COG4258@2|Bacteria,4PKBM@976|Bacteroidetes,1HYZW@117743|Flavobacteriia,2NT2E@237|Flavobacterium 976|Bacteroidetes I glycerol acyltransferase - - - ko:K07003 - - - - ko00000 - - - Acyltransferase,MMPL,Methyltransf_25,Methyltransf_31 k59_1262962_1 208439.AJAP_28560 3.27e-05 47.8 COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4E0QR@85010|Pseudonocardiales 201174|Actinobacteria S Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Reductase_C k59_843244_1 765912.Thimo_0009 1.24e-90 286.0 COG3436@1|root,COG3436@2|Bacteria,1MYAC@1224|Proteobacteria,1T2KH@1236|Gammaproteobacteria,1X2VE@135613|Chromatiales 135613|Chromatiales L IS66 C-terminal element - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C k59_216300_1 583355.Caka_2360 5.88e-30 112.0 COG0131@1|root,COG0131@2|Bacteria,46UDT@74201|Verrucomicrobia,3K7V8@414999|Opitutae 414999|Opitutae E imidazoleglycerol-phosphate dehydratase hisB - 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD k59_688247_1 83406.HDN1F_20050 4.34e-11 69.3 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1J6H5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M silverDB - - - - - - - - - - - - DUF11,RHS,RHS_repeat k59_1365545_1 1304865.JAGF01000001_gene3857 1.19e-110 350.0 COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4F11C@85016|Cellulomonadaceae 201174|Actinobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_1262971_2 754477.Q7C_338 6.14e-17 79.7 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RM88@1236|Gammaproteobacteria,460J7@72273|Thiotrichales 72273|Thiotrichales I Fatty acid desaturase ole1 - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_1156448_1 998674.ATTE01000001_gene458 1.61e-95 290.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria,45ZW0@72273|Thiotrichales 72273|Thiotrichales F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_895659_2 861299.J421_2742 4.79e-41 156.0 COG1138@1|root,COG1138@2|Bacteria,1ZTBY@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Cytochrome c-type biogenesis protein CcmF C-terminal - - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_688249_1 745014.OMB55_00020110 1.16e-90 283.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,1RME6@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the formate--tetrahydrofolate ligase family fhs GO:0000096,GO:0000097,GO:0000105,GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006520,GO:0006547,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009108,GO:0009110,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0052803,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_1313046_1 330214.NIDE0987 4.29e-55 178.0 COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,3J0T7@40117|Nitrospirae 40117|Nitrospirae E Phosphoribosyl-AMP cyclohydrolase hisI - 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH,PRA-PH k59_1313046_2 330214.NIDE0986 8.93e-36 128.0 COG0107@1|root,COG0107@2|Bacteria,3J0GV@40117|Nitrospirae 40117|Nitrospirae E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_529557_1 396588.Tgr7_0563 1.29e-14 73.2 COG1416@1|root,COG1416@2|Bacteria,1MYMK@1224|Proteobacteria,1SD2F@1236|Gammaproteobacteria,1X1AM@135613|Chromatiales 135613|Chromatiales K AntiSigma factor - - - ko:K09004 - - - - ko00000 - - - - k59_373025_1 1045855.DSC_11620 7.45e-65 211.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1X31Z@135614|Xanthomonadales 135614|Xanthomonadales S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_216307_1 1280950.HJO_16090 2.95e-100 312.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,43ZDV@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Sulfatase - - - - - - - - - - - - Sulfatase k59_1210876_1 349521.HCH_04987 1.87e-124 369.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,1RN8U@1236|Gammaproteobacteria,1XIKN@135619|Oceanospirillales 135619|Oceanospirillales C Catalyzes the reversible hydration of fumarate to (S)- malate fumA - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_61710_1 330214.NIDE0400 1.84e-61 191.0 COG0292@1|root,COG0292@2|Bacteria,3J0SF@40117|Nitrospirae 40117|Nitrospirae J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_1626698_1 1229909.NSED_08125 3.5e-21 90.5 COG0506@1|root,arCOG06322@2157|Archaea,41SY1@651137|Thaumarchaeota 651137|Thaumarchaeota E Proline dehydrogenase - - - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh k59_688265_1 448385.sce0197 4.43e-81 278.0 COG3857@1|root,COG3857@2|Bacteria 2|Bacteria L exonuclease activity addB - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - Exonuc_V_gamma,PDDEXK_1,UvrD_C k59_738538_1 649638.Trad_1018 1.22e-64 214.0 COG1966@1|root,COG1966@2|Bacteria,1WMNS@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T 5TM C-terminal transporter carbon starvation CstA - - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM k59_321449_1 765869.BDW_08330 6.89e-47 163.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2MSR7@213481|Bdellovibrionales,2WIMT@28221|Deltaproteobacteria 213481|Bdellovibrionales J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_1262999_2 596151.DesfrDRAFT_0618 9.61e-13 71.2 COG1807@1|root,COG1807@2|Bacteria,1NTFE@1224|Proteobacteria,42Z1W@68525|delta/epsilon subdivisions,2WTMJ@28221|Deltaproteobacteria,2M8VB@213115|Desulfovibrionales 28221|Deltaproteobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_1156471_1 351348.Maqu_0871 9.52e-09 61.6 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,46578@72275|Alteromonadaceae 1236|Gammaproteobacteria NU Tfp pilus assembly protein tip-associated adhesin pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_111216_1 42565.FP66_10455 1.67e-42 152.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1XI3H@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_216324_1 644966.Tmar_1102 3.57e-09 65.1 COG0438@1|root,COG0438@2|Bacteria,1TPS8@1239|Firmicutes 1239|Firmicutes M glycosyl transferase group 1 - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_529576_1 1254432.SCE1572_37885 2.91e-10 66.6 COG1520@1|root,COG1520@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - - - - - - - - - - - FG-GAP_2,PQQ_2 k59_1471087_1 1229909.NSED_09655 1.14e-32 122.0 COG3794@1|root,arCOG02926@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1 k59_1210909_2 1254432.SCE1572_26495 1.97e-61 210.0 COG4581@1|root,COG4581@2|Bacteria,1QUPR@1224|Proteobacteria,42NSH@68525|delta/epsilon subdivisions,2WKD7@28221|Deltaproteobacteria,2YUGZ@29|Myxococcales 28221|Deltaproteobacteria L DEAD DEAH box helicase - - - - - - - - - - - - DEAD,DSHCT,DUF3516,Helicase_C k59_581835_1 648757.Rvan_1163 1.04e-21 100.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3N8NB@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria K Adenylate cyclase - - - - - - - - - - - - GerE,Guanylate_cyc,TIR_2,TPR_16,TPR_8,Trans_reg_C k59_895689_1 1050202.KB913024_gene3556 7.95e-12 68.6 COG1820@1|root,COG1820@2|Bacteria,2GK1E@201174|Actinobacteria,407PT@622450|Actinopolysporales 201174|Actinobacteria G Amidohydrolase family nagA - 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 - R02059 RC00166,RC00300 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_895689_2 224911.27350975 7.44e-32 123.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,3JRJV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E GMC oxidoreductase MA20_17575 - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_1365586_1 1123355.JHYO01000023_gene2369 5.95e-21 96.3 COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2TSE9@28211|Alphaproteobacteria,36Z06@31993|Methylocystaceae 28211|Alphaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_636269_1 671143.DAMO_1341 7.98e-67 218.0 COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria 2|Bacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS10690,iYO844.BSU28280 HMGL-like,LeuA_dimer k59_1417746_1 246196.MSMEI_3470 9.58e-58 194.0 COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,232KS@1762|Mycobacteriaceae 201174|Actinobacteria Q cytochrome p450 cyp124A1 GO:0000166,GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0009987,GO:0010430,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0019395,GO:0019752,GO:0020037,GO:0030258,GO:0031073,GO:0032787,GO:0034440,GO:0036094,GO:0036199,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044282,GO:0046164,GO:0046906,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0070402,GO:0071704,GO:0097089,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652 1.14.15.14 ko:K20497 - - - - ko00000,ko00199,ko01000 - - - p450 k59_1371834_2 243233.MCA0044 5.07e-27 100.0 2E3CN@1|root,32YBX@2|Bacteria,1N716@1224|Proteobacteria,1SEFN@1236|Gammaproteobacteria,1XGNQ@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - k59_1271352_1 329726.AM1_6326 1.79e-62 202.0 COG3039@1|root,COG3039@2|Bacteria,1G7AF@1117|Cyanobacteria 1117|Cyanobacteria L Transposase IS4 family - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_5 k59_431364_1 1267534.KB906754_gene2701 3.64e-57 194.0 COG0443@1|root,COG0443@2|Bacteria,3Y2XU@57723|Acidobacteria,2JHT1@204432|Acidobacteriia 204432|Acidobacteriia O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1005817_3 1396141.BATP01000044_gene1480 4.74e-06 47.4 COG0174@1|root,COG0174@2|Bacteria,46S5C@74201|Verrucomicrobia,2ITKG@203494|Verrucomicrobiae 203494|Verrucomicrobiae E Glutamine synthetase, catalytic domain - - - - - - - - - - - - Gln-synt_C,Gln-synt_N k59_1271357_1 671143.DAMO_0515 2.55e-32 127.0 COG0305@1|root,COG0305@2|Bacteria,2NNKG@2323|unclassified Bacteria 2|Bacteria L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_431365_1 7955.ENSDARP00000069178 1.51e-12 71.6 COG1233@1|root,KOG4254@2759|Eukaryota,38GIP@33154|Opisthokonta,3BGWD@33208|Metazoa,3CXHQ@33213|Bilateria,4899J@7711|Chordata,492H2@7742|Vertebrata,49WMX@7898|Actinopterygii 33208|Metazoa H Retinol saturase (all-trans-retinol 13,14-reductase) like - GO:0001523,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006066,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0009987,GO:0010817,GO:0016101,GO:0016491,GO:0016627,GO:0034308,GO:0034754,GO:0042445,GO:0042572,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044464,GO:0051786,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901615 1.3.99.23 ko:K09516 ko00830,map00830 - R07163 RC01835 ko00000,ko00001,ko01000 - - - Amino_oxidase,NAD_binding_8 k59_431365_2 1121937.AUHJ01000002_gene3618 8.53e-17 83.6 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,4668R@72275|Alteromonadaceae 1236|Gammaproteobacteria G PQQ enzyme repeat - - - - - - - - - - - - PQQ,PQQ_2 k59_485801_1 679937.Bcop_0156 0.000276 43.1 COG0039@1|root,COG0039@2|Bacteria,4NEJ7@976|Bacteroidetes,2FM7E@200643|Bacteroidia,4ANBW@815|Bacteroidaceae 976|Bacteroidetes C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_485801_2 472759.Nhal_3892 3.04e-46 167.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1WWH1@135613|Chromatiales 135613|Chromatiales M TIGRFAM penicillin-binding protein, 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_1110887_1 391615.ABSJ01000026_gene120 4.57e-30 122.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,1J52P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_1110887_2 641491.DND132_2595 2.24e-11 66.6 COG4254@1|root,COG4254@2|Bacteria,1N739@1224|Proteobacteria,42VBI@68525|delta/epsilon subdivisions,2WRCH@28221|Deltaproteobacteria,2MCTM@213115|Desulfovibrionales 28221|Deltaproteobacteria S FecR protein - - - - - - - - - - - - FecR k59_431376_1 443143.GM18_4037 2.79e-41 156.0 COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,42T0V@68525|delta/epsilon subdivisions,2WPRT@28221|Deltaproteobacteria,43TPS@69541|Desulfuromonadales 28221|Deltaproteobacteria M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11,SdrD_B k59_535855_1 479431.Namu_4703 2.35e-110 333.0 COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4ESB0@85013|Frankiales 201174|Actinobacteria C Belongs to the citrate synthase family gltA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_168407_1 1232410.KI421421_gene3800 1.16e-11 67.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,42PT6@68525|delta/epsilon subdivisions,2WK6I@28221|Deltaproteobacteria,43S53@69541|Desulfuromonadales 28221|Deltaproteobacteria M Glycosyltransferase Family 4 - - 2.4.1.345 ko:K08256 - - R11702 - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_168407_2 1123009.AUID01000009_gene486 1.03e-25 107.0 COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia,267UV@186813|unclassified Clostridiales 186801|Clostridia C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_1217427_2 445686.E3SLB9_9CAUD 6.3e-72 221.0 4QBYS@10239|Viruses,4QWVI@35237|dsDNA viruses no RNA stage,4QPJ8@28883|Caudovirales,4QI9H@10662|Myoviridae 10662|Myoviridae S alternative oxidase activity - - - - - - - - - - - - - k59_168410_1 1265503.KB905165_gene1223 2.63e-12 66.6 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,2Q5T2@267889|Colwelliaceae 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0032774,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_168410_2 521098.Aaci_1232 3.12e-32 122.0 COG1932@1|root,COG1932@2|Bacteria,1TP6Y@1239|Firmicutes,4HATT@91061|Bacilli 91061|Bacilli E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_1580291_2 444860.E3SIQ6_9CAUD 3.89e-138 394.0 4QAX9@10239|Viruses,4QVNY@35237|dsDNA viruses no RNA stage,4QPQH@28883|Caudovirales,4QHWN@10662|Myoviridae 10662|Myoviridae S T4 bacteriophage base plate protein - - - - - - - - - - - - - k59_1524042_1 1121438.JNJA01000023_gene385 2.3e-73 236.0 COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,42MU7@68525|delta/epsilon subdivisions,2WJFQ@28221|Deltaproteobacteria,2M7TJ@213115|Desulfovibrionales 28221|Deltaproteobacteria J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - - Se-cys_synth_N,SelA k59_1058696_1 247634.GPB2148_1864 1.7e-18 86.7 COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,1J6CU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the DnaA family. HdA subfamily hda GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113 - ko:K10763 - - - - ko00000,ko03032 - - - Bac_DnaA k59_588261_2 335543.Sfum_3011 1.15e-15 79.7 COG2234@1|root,COG2234@2|Bacteria,1MXZS@1224|Proteobacteria,42S82@68525|delta/epsilon subdivisions,2WNUR@28221|Deltaproteobacteria,2MR3S@213462|Syntrophobacterales 28221|Deltaproteobacteria S PFAM peptidase M28 - - - - - - - - - - - - Peptidase_M28 k59_1318404_1 941449.dsx2_0363 2.06e-67 228.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2M9PX@213115|Desulfovibrionales 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_222806_1 1249627.D779_1245 4.23e-61 212.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1217438_1 671143.DAMO_2028 1.36e-86 267.0 COG5421@1|root,COG5421@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2 k59_1425798_1 699246.HMPREF0868_0178 1.28e-08 58.2 COG1253@1|root,COG3064@1|root,COG1253@2|Bacteria,COG3064@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,267YU@186813|unclassified Clostridiales 186801|Clostridia M Psort location CytoplasmicMembrane, score - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_849497_2 765912.Thimo_2429 1.57e-27 105.0 COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1WYJU@135613|Chromatiales 135613|Chromatiales S Modulates RecA activity recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX k59_801740_1 305900.GV64_12160 3.33e-85 268.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1XITD@135619|Oceanospirillales 135619|Oceanospirillales J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_1318409_1 1247726.MIM_c38350 1.39e-26 112.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,3T3AW@506|Alcaligenaceae 28216|Betaproteobacteria C CoA binding domain - - - - - - - - - - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,Acetyltransf_4,CoA_binding_2,Succ_CoA_lig k59_1271411_1 1232410.KI421415_gene2933 2.38e-32 125.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1271411_2 264462.Bd2437 5.21e-16 79.0 COG0543@1|root,COG0543@2|Bacteria,1MV72@1224|Proteobacteria,43C9Q@68525|delta/epsilon subdivisions,2MUT7@213481|Bdellovibrionales,2X7K8@28221|Deltaproteobacteria 213481|Bdellovibrionales C Phenol 2-monooxygenase - - - - - - - - - - - - FAD_binding_6,NAD_binding_1 k59_1479436_1 396588.Tgr7_3316 7.19e-104 319.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1WXBH@135613|Chromatiales 135613|Chromatiales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_849505_1 458817.Shal_2671 1.13e-26 112.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,2Q8TA@267890|Shewanellaceae 1236|Gammaproteobacteria I Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed fadI GO:0003674,GO:0003824,GO:0003857,GO:0003988,GO:0004300,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033542,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_2806,iEcHS_1320.EcHS_A2493 Thiolase_C,Thiolase_N k59_70030_1 1122214.AQWH01000012_gene3761 1.65e-77 247.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,2PJS9@255475|Aurantimonadaceae 28211|Alphaproteobacteria E GMC oxidoreductase MA20_17575 - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_694717_1 477641.MODMU_1118 2.16e-19 92.8 COG0654@1|root,COG0654@2|Bacteria,2I901@201174|Actinobacteria,4EVBK@85013|Frankiales 201174|Actinobacteria CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - - - - - - - - - - DAO,FAD_binding_2,NAD_binding_8,Trp_halogenase k59_1318418_1 519989.ECTPHS_07491 7.62e-13 67.4 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,1WY8N@135613|Chromatiales 135613|Chromatiales KT Response regulator of the LytR AlgR family - - - ko:K08083 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_1318418_2 247633.GP2143_15891 2.11e-28 113.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1J5V1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction protein with a C-terminal ATPase domain algZ - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase k59_901982_1 639283.Snov_2878 4.33e-15 75.9 COG1192@1|root,COG1192@2|Bacteria,1MWRE@1224|Proteobacteria,2TSJZ@28211|Alphaproteobacteria,3EZ2N@335928|Xanthobacteraceae 28211|Alphaproteobacteria D PFAM Cobyrinic acid ac-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_901982_2 765912.Thimo_2956 6.66e-34 118.0 COG2154@1|root,COG2154@2|Bacteria,1N7XJ@1224|Proteobacteria,1T12K@1236|Gammaproteobacteria,1X2MX@135613|Chromatiales 135613|Chromatiales H Pterin 4 alpha carbinolamine dehydratase - - - - - - - - - - - - Pterin_4a k59_901982_3 314278.NB231_15203 1.39e-55 179.0 COG2193@1|root,COG2193@2|Bacteria,1PE4V@1224|Proteobacteria,1SAG5@1236|Gammaproteobacteria,1WZ24@135613|Chromatiales 135613|Chromatiales P Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex - - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_1058725_1 330214.NIDE0694 1.09e-74 242.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,3J117@40117|Nitrospirae 2|Bacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF,GAF_2,HATPase_c,HisKA k59_431430_1 1318628.MARLIPOL_17283 2.44e-10 67.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,46578@72275|Alteromonadaceae 1236|Gammaproteobacteria NU Tfp pilus assembly protein tip-associated adhesin pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_6521_1 641491.DND132_1639 1.06e-49 181.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,2M7SV@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM penicillin-binding protein transpeptidase ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase k59_953544_1 1158760.AQXP01000031_gene894 3.29e-27 107.0 COG3642@1|root,COG3642@2|Bacteria,1RDW7@1224|Proteobacteria,1S46R@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position kdkA - 2.7.1.166 ko:K11211 ko00540,map00540 - R09767 RC00002,RC00078 ko00000,ko00001,ko01000 - - - Kdo k59_953544_2 1269813.ATUL01000001_gene1087 7.54e-70 223.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria,1X2HB@135613|Chromatiales 135613|Chromatiales M Glycosyltransferase family 9 (heptosyltransferase) - - - ko:K02849 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_1005882_1 913325.N799_13305 6.79e-12 65.1 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1X4SS@135614|Xanthomonadales 135614|Xanthomonadales C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_1005882_2 391615.ABSJ01000045_gene1968 2.59e-13 67.4 2EFX9@1|root,339PI@2|Bacteria,1NI0D@1224|Proteobacteria,1SGKH@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_275097_1 497321.C664_02595 8e-59 188.0 COG2032@1|root,COG2032@2|Bacteria,1RGV4@1224|Proteobacteria,2WFV1@28216|Betaproteobacteria,2KYNS@206389|Rhodocyclales 206389|Rhodocyclales P Copper/zinc superoxide dismutase (SODC) - - 1.15.1.1 ko:K04565 ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020 - - - ko00000,ko00001,ko01000 - - - Sod_Cu k59_275097_2 153948.NAL212_1708 5.86e-20 87.0 COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,2VR0S@28216|Betaproteobacteria,372JA@32003|Nitrosomonadales 28216|Betaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_222842_1 981384.AEYW01000001_gene1490 1.81e-85 267.0 COG1234@1|root,COG1234@2|Bacteria,1RIJP@1224|Proteobacteria 1224|Proteobacteria S Metallo-beta-lactamase superfamily - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B,Lactamase_B_4 k59_431444_1 379066.GAU_3916 6.6e-19 82.8 COG0494@1|root,COG0494@2|Bacteria,1ZTQ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes L NUDIX domain - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_1161818_1 2340.JV46_11610 5.98e-19 80.5 COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,1S8RW@1236|Gammaproteobacteria,1JBM2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S MazG-like family - - - - - - - - - - - - MazG-like k59_70069_1 436308.Nmar_0270 3.15e-119 351.0 COG0470@1|root,arCOG00470@2157|Archaea,41S9F@651137|Thaumarchaeota 651137|Thaumarchaeota L ATPase family associated with various cellular activities (AAA) - - - ko:K04800 ko03030,map03030 - - - ko00000,ko00001,ko03032 - - - AAA k59_1479476_1 1294143.H681_04485 4.95e-95 287.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_380412_1 335543.Sfum_1457 3.41e-88 289.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MR4N@213462|Syntrophobacterales 28221|Deltaproteobacteria V Protein export membrane protein bepE - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1425852_1 1202962.KB907176_gene87 3.48e-64 209.0 COG3977@1|root,COG3977@2|Bacteria,1MVRW@1224|Proteobacteria,1RNK1@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Valine--pyruvate aminotransferase avtA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009042,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0030632,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.66 ko:K00835 ko00290,ko01100,ko01110,ko01130,map00290,map01100,map01110,map01130 - R01215 RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - iEKO11_1354.EKO11_0154,iEcSMS35_1347.EcSMS35_3895 Aminotran_1_2 k59_1425854_1 1121430.JMLG01000002_gene1089 4.8e-55 191.0 COG4666@1|root,COG4666@2|Bacteria,1TP0V@1239|Firmicutes,248AI@186801|Clostridia,260EE@186807|Peptococcaceae 1239|Firmicutes S TIGRFAM TRAP transporter, 4TM 12TM fusion protein - - - - - - - - - - - - DUF3394,DctM k59_275115_2 1165096.ARWF01000001_gene1732 9.59e-50 172.0 COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,2VHBF@28216|Betaproteobacteria,2KM9X@206350|Nitrosomonadales 206350|Nitrosomonadales M MltA specific insert domain - - - ko:K08304 - - - - ko00000,ko01000,ko01011 - GH102 - 3D,MltA k59_694753_1 566466.NOR53_708 2.96e-41 150.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPGB@1236|Gammaproteobacteria,1J8SN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_431467_1 1249627.D779_0302 2.01e-10 62.0 COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,1RZQ2@1236|Gammaproteobacteria,1WXSM@135613|Chromatiales 135613|Chromatiales Q Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_1161828_1 306281.AJLK01000117_gene4234 8.14e-66 219.0 COG0451@1|root,COG0451@2|Bacteria 2|Bacteria GM ADP-glyceromanno-heptose 6-epimerase activity CP_0535 - 2.3.1.94,5.1.3.2 ko:K01784,ko:K10817,ko:K12443,ko:K15672 ko00052,ko00520,ko00522,ko01051,ko01052,ko01100,ko01130,map00052,map00520,map00522,map01051,map01052,map01100,map01130 M00361,M00362,M00632,M00774 R00291,R00918,R02984 RC00004,RC00289,RC02825,RC02826,RC02828,RC02829,RC02830,RC02831 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 - - - Acyl_transf_1,Epimerase,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,SPW,VKOR,ketoacyl-synt k59_432378_2 330214.NIDE3827 1.82e-14 73.2 COG2854@1|root,COG2854@2|Bacteria,3J13Z@40117|Nitrospirae 40117|Nitrospirae Q Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_169251_1 713586.KB900536_gene2382 4.2e-40 140.0 COG1278@1|root,COG1278@2|Bacteria,1QW5N@1224|Proteobacteria,1T3Z1@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Sigma 54 modulation protein / S30EA ribosomal protein - - - - - - - - - - - - CSD,Ribosomal_S30AE k59_328646_1 1122603.ATVI01000005_gene3040 1.5e-52 180.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1X4NW@135614|Xanthomonadales 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_1480482_1 225937.HP15_585 8.33e-104 309.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,4655B@72275|Alteromonadaceae 1236|Gammaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_745662_1 331869.BAL199_03124 1.15e-20 89.4 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria,4BQ72@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase carnithine racemase - - 4.1.1.41,4.2.1.17 ko:K01692,ko:K11264 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R00923,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00097,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_695558_1 246196.MSMEI_0647 3.16e-79 252.0 COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,234PD@1762|Mycobacteriaceae 201174|Actinobacteria Q NAD(P)-binding Rossmann-like domain - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_169269_1 264198.Reut_B5856 1.59e-24 105.0 COG0845@1|root,COG0845@2|Bacteria,1MUMV@1224|Proteobacteria,2VIYG@28216|Betaproteobacteria,1K520@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_645755_1 1121943.KB900012_gene4060 1.46e-65 208.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,1RR8F@1236|Gammaproteobacteria,1XRIQ@135619|Oceanospirillales 135619|Oceanospirillales L Integrase core domain - - - - - - - - - - - - HTH_21,rve_3 k59_959645_2 436308.Nmar_0984 2.73e-13 69.3 COG0340@1|root,arCOG01940@2157|Archaea,41SI3@651137|Thaumarchaeota 651137|Thaumarchaeota H biotin-(Acetyl-CoA-carboxylase) ligase - - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k59_856352_2 314278.NB231_04125 2.12e-86 263.0 COG3751@1|root,COG3751@2|Bacteria,1RAJ8@1224|Proteobacteria,1S3II@1236|Gammaproteobacteria 1236|Gammaproteobacteria O 2OG-Fe(II) oxygenase superfamily - - - - - - - - - - - - - k59_494612_1 1545915.JROG01000001_gene564 5.97e-22 93.2 COG2141@1|root,COG2141@2|Bacteria,1MWMV@1224|Proteobacteria,2TTIQ@28211|Alphaproteobacteria,2K0FP@204457|Sphingomonadales 204457|Sphingomonadales C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - 1.14.14.5 ko:K04091 ko00920,map00920 - R07210,R10206 RC01779,RC02556 ko00000,ko00001,ko01000 - - - Bac_luciferase k59_494612_2 1313172.YM304_24500 3.07e-119 354.0 COG0673@1|root,COG0673@2|Bacteria 2|Bacteria S inositol 2-dehydrogenase activity - - 1.1.1.18,1.1.1.369 ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 - R01183,R09951 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_594855_1 246197.MXAN_5345 7.05e-111 347.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2YU97@29|Myxococcales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_959646_1 765912.Thimo_2233 2.04e-07 51.2 COG1051@1|root,COG4111@1|root,COG1051@2|Bacteria,COG4111@2|Bacteria,1MXHA@1224|Proteobacteria,1T1QN@1236|Gammaproteobacteria,1WYUW@135613|Chromatiales 135613|Chromatiales F NUDIX domain - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_959646_2 1469245.JFBG01000019_gene1130 4.66e-104 311.0 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales 135613|Chromatiales P Belongs to the sulfate adenylyltransferase family sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_334330_1 937774.TEQUI_0336 6.18e-108 327.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHES@28216|Betaproteobacteria,3T1RK@506|Alcaligenaceae 28216|Betaproteobacteria S ABC transporter, ATP-binding protein yjjK - 3.6.3.25 ko:K06020 - - - - ko00000,ko01000 - - - ABC_tran,ABC_tran_Xtn k59_173907_2 396588.Tgr7_1248 1.18e-47 161.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1WWMZ@135613|Chromatiales 135613|Chromatiales E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_856361_1 325452.fgenesh_scip_prom.46568.4555 1.56e-93 300.0 COG3119@1|root,COG3250@1|root,KOG2024@2759|Eukaryota,KOG3867@2759|Eukaryota 2759|Eukaryota P sulfuric ester hydrolase activity - - 3.2.1.23 ko:K01190,ko:K17592 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000,ko01009 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Sulfatase k59_1528645_1 744980.TRICHSKD4_5207 1.63e-76 236.0 COG1024@1|root,COG1024@2|Bacteria,1NDT7@1224|Proteobacteria,2U2R9@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1012596_1 1122599.AUGR01000002_gene3656 4.88e-10 62.4 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1RMW7@1236|Gammaproteobacteria,1XJV7@135619|Oceanospirillales 135619|Oceanospirillales K transcriptional regulator - - - ko:K07662 ko01503,ko02020,map01503,map02020 M00447,M00727,M00728 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_810524_1 477184.KYC_21034 1.78e-42 152.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,2VKAH@28216|Betaproteobacteria,3T1BD@506|Alcaligenaceae 28216|Betaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_810525_1 55601.VANGNB10_cI2658c 1.88e-63 201.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1XSR2@135623|Vibrionales 135623|Vibrionales H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_126152_1 436308.Nmar_0031 6.4e-07 53.1 arCOG10512@1|root,arCOG10512@2157|Archaea,41T3J@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_126152_2 436308.Nmar_0029 1.98e-09 57.4 COG5491@1|root,arCOG00452@2157|Archaea,41SYC@651137|Thaumarchaeota 651137|Thaumarchaeota D conserved protein implicated in secretion - - - - - - - - - - - - - k59_1528646_1 292459.STH2562 7.73e-32 128.0 COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia 186801|Clostridia C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_494631_1 1254432.SCE1572_14660 3.16e-79 248.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NF6@68525|delta/epsilon subdivisions,2WKVH@28221|Deltaproteobacteria 28221|Deltaproteobacteria V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_9640_1 1198452.Jab_2c33730 1.25e-44 160.0 COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,2VH73@28216|Betaproteobacteria,476PV@75682|Oxalobacteraceae 28216|Betaproteobacteria S Putative aminopeptidase - - - - - - - - - - - - Aminopep k59_1280482_2 118166.JH976538_gene5132 7.4e-123 362.0 COG2801@1|root,COG2801@2|Bacteria,1G5RM@1117|Cyanobacteria,1HHPH@1150|Oscillatoriales 1117|Cyanobacteria L Integrase core domain - - - - - - - - - - - - HTH_23,HTH_32,rve k59_229125_1 1283300.ATXB01000001_gene1084 3.96e-71 234.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1XE6A@135618|Methylococcales 135618|Methylococcales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - COX15-CtaA,SRP54,SRP54_N k59_1434374_1 1123279.ATUS01000001_gene2531 5.73e-80 251.0 COG3804@1|root,COG3804@2|Bacteria,1R6QX@1224|Proteobacteria,1SN27@1236|Gammaproteobacteria,1J8PU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Dihydrodipicolinate reductase, N-terminus - - - - - - - - - - - - DapB_N k59_78778_1 1123060.JONP01000007_gene5133 1.84e-55 187.0 COG2391@1|root,COG2391@2|Bacteria,1PF9B@1224|Proteobacteria,2TU5N@28211|Alphaproteobacteria,2JQTX@204441|Rhodospirillales 204441|Rhodospirillales S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_810544_1 237368.SCABRO_00770 1.58e-15 76.6 COG3659@1|root,COG3659@2|Bacteria 2|Bacteria M wide pore channel activity oprB - - ko:K07267 - - - - ko00000,ko02000 1.B.19.1 - - OprB k59_438977_1 1121374.KB891580_gene1789 5.07e-28 113.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_438977_2 546267.NEIPOLOT_00402 0.000156 45.8 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,2KQ4C@206351|Neisseriales 206351|Neisseriales J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon gluQ - - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c k59_1488108_1 1121028.ARQE01000002_gene2006 6.84e-20 90.5 COG2020@1|root,COG2020@2|Bacteria,1PDMB@1224|Proteobacteria,2VAAR@28211|Alphaproteobacteria,2PK7W@255475|Aurantimonadaceae 28211|Alphaproteobacteria O Phospholipid methyltransferase - - - - - - - - - - - - PEMT k59_1641098_1 748280.NH8B_2634 9.78e-21 94.4 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,2KQAT@206351|Neisseriales 206351|Neisseriales I Domain of unknown function (DUF1974) - - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_1166880_1 105559.Nwat_2894 4.4e-176 526.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,Response_reg k59_127148_1 1380394.JADL01000004_gene5821 2.73e-67 229.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,2JPDT@204441|Rhodospirillales 204441|Rhodospirillales L DEAD/H associated - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_654582_1 105559.Nwat_2310 2.4e-07 50.8 COG3298@1|root,COG3298@2|Bacteria,1MVZJ@1224|Proteobacteria,1S4HU@1236|Gammaproteobacteria,1X0C4@135613|Chromatiales 135613|Chromatiales L 3'-5' exonuclease - - - ko:K07501 - - - - ko00000 - - - DNA_pol_B_exo2 k59_654582_2 686340.Metal_3128 1.66e-39 139.0 COG3784@1|root,COG3784@2|Bacteria,1MYIH@1224|Proteobacteria,1S8D2@1236|Gammaproteobacteria,1XEZY@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF1318) - - - - - - - - - - - - DUF1318 k59_857229_1 1125863.JAFN01000001_gene2812 8.65e-36 137.0 COG3043@1|root,COG3043@2|Bacteria 1125863.JAFN01000001_gene2812|- C anaerobic respiration - - - - - - - - - - - - - k59_654587_1 697282.Mettu_2701 2.75e-66 221.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1XE8E@135618|Methylococcales 135618|Methylococcales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_654587_2 1122197.ATWI01000009_gene1705 4.94e-22 95.5 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,464AT@72275|Alteromonadaceae 1236|Gammaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der GO:0000027,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0022613,GO:0022618,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363 - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_9999_1 1236497.BAJQ01000035_gene205 2.02e-54 179.0 COG0568@1|root,COG0568@2|Bacteria,4NEBF@976|Bacteroidetes,2FNVQ@200643|Bacteroidia 976|Bacteroidetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_282800_2 330214.NIDE3959 2.3e-52 174.0 COG2905@1|root,COG2905@2|Bacteria 2|Bacteria T signal-transduction protein containing cAMP-binding and CBS domains - - 1.1.1.42,1.3.1.85 ko:K00031,ko:K14446 ko00020,ko00480,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00373,M00740 R00267,R00268,R01899,R09291 RC00001,RC00084,RC00114,RC00626,RC02481,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - CBS,GGDEF,PAS_9 k59_439987_2 1229909.NSED_09165 2.11e-60 198.0 COG0452@1|root,arCOG01704@2157|Archaea,41SYG@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine - - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_857248_1 87626.PTD2_07984 1.48e-40 148.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,2PZUM@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008784,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0019842,GO:0030170,GO:0030203,GO:0034645,GO:0036094,GO:0036361,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0048037,GO:0050662,GO:0070279,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - iPC815.YPO0321,iSBO_1134.SBO_4064,iSbBS512_1146.SbBS512_E4542,iYL1228.KPN_04440 Ala_racemase_C,Ala_racemase_N k59_909622_1 1463820.JOGW01000002_gene5849 5.27e-21 88.2 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - ko:K21700 - - - - ko00000 - - - 3-HAO,Cupin_2 k59_1013523_1 1229909.NSED_04830 3.7e-96 293.0 COG0436@1|root,arCOG01130@2157|Archaea 2157|Archaea E PFAM Aminotransferase class I and II - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_811730_1 1229909.NSED_01965 3.03e-124 361.0 COG0130@1|root,arCOG00987@2157|Archaea,41S8E@651137|Thaumarchaeota 651137|Thaumarchaeota J Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs truB - - ko:K11131 ko03008,map03008 M00425 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03032 - - - DKCLD,PUA,TruB_C_2,TruB_N k59_79958_1 1449069.JMLO01000005_gene1343 2.22e-52 184.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FUZV@85025|Nocardiaceae 201174|Actinobacteria IQ synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_127190_1 879212.DespoDRAFT_02660 1.28e-60 201.0 COG3385@1|root,COG3385@2|Bacteria,1NNH0@1224|Proteobacteria 1224|Proteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - - k59_79960_2 330214.NIDE2773 9.03e-65 200.0 COG0521@1|root,COG0521@2|Bacteria 2|Bacteria H Mo-molybdopterin cofactor metabolic process moaB - 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_1066379_1 1254432.SCE1572_03080 1.53e-83 276.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2YUJI@29|Myxococcales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_127200_2 713586.KB900536_gene1653 1.33e-96 288.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,1WW7W@135613|Chromatiales 135613|Chromatiales E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_440019_1 251229.Chro_5388 2.63e-46 165.0 COG0405@1|root,COG0405@2|Bacteria,1G20A@1117|Cyanobacteria,3VJBY@52604|Pleurocapsales 1117|Cyanobacteria E Gamma-glutamyltranspeptidase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1066389_1 1281779.H009_09996 4.99e-36 140.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria,4B7A5@82115|Rhizobiaceae 28211|Alphaproteobacteria M penicillin-binding protein mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_230030_1 3983.cassava4.1_005801m 0.000714 47.4 COG0500@1|root,KOG1269@2759|Eukaryota,37MW5@33090|Viridiplantae,3G8XR@35493|Streptophyta,4JH7B@91835|fabids 35493|Streptophyta I Phosphoethanolamine N-methyltransferase - GO:0000003,GO:0000902,GO:0000904,GO:0001505,GO:0003006,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006629,GO:0006644,GO:0006650,GO:0006656,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0007275,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008610,GO:0008654,GO:0008757,GO:0009058,GO:0009308,GO:0009309,GO:0009555,GO:0009605,GO:0009653,GO:0009791,GO:0009826,GO:0009856,GO:0009860,GO:0009932,GO:0009987,GO:0010183,GO:0016043,GO:0016049,GO:0016740,GO:0016741,GO:0019637,GO:0019695,GO:0022414,GO:0022622,GO:0030154,GO:0032259,GO:0032501,GO:0032502,GO:0032989,GO:0034641,GO:0040007,GO:0040011,GO:0042133,GO:0042136,GO:0042221,GO:0042330,GO:0042401,GO:0042425,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044706,GO:0045017,GO:0046470,GO:0046474,GO:0046486,GO:0048229,GO:0048364,GO:0048468,GO:0048528,GO:0048588,GO:0048589,GO:0048731,GO:0048856,GO:0048868,GO:0048869,GO:0050896,GO:0050918,GO:0051704,GO:0052667,GO:0060560,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0090407,GO:0090696,GO:0097164,GO:0099402,GO:1901564,GO:1901566,GO:1901576 2.1.1.103 ko:K05929 ko00564,map00564 - R02037,R06868,R06869 RC00003,RC00060,RC00181,RC00496 ko00000,ko00001,ko01000 - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 k59_1118304_1 472759.Nhal_3427 2.5e-95 290.0 COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,1WWZ4@135613|Chromatiales 135613|Chromatiales C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_1588074_1 391625.PPSIR1_11676 4.96e-76 242.0 COG0516@1|root,COG0516@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2WJ5H@28221|Deltaproteobacteria,2Z02X@29|Myxococcales 28221|Deltaproteobacteria F IMP dehydrogenase / GMP reductase domain guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_1013545_1 1049564.TevJSym_aa01910 9.24e-73 220.0 COG3255@1|root,COG3255@2|Bacteria,1RI49@1224|Proteobacteria,1S38T@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Sterol carrier protein - - - - - - - - - - - - - k59_1435586_2 335543.Sfum_3248 8.04e-19 80.5 2EQZT@1|root,33IJD@2|Bacteria,1NKTX@1224|Proteobacteria,42XNG@68525|delta/epsilon subdivisions,2WTCK@28221|Deltaproteobacteria,2MQPM@213462|Syntrophobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1167596_1 330214.NIDE2574 2.56e-94 290.0 COG0138@1|root,COG0138@2|Bacteria,3J0CV@40117|Nitrospirae 40117|Nitrospirae F AICARFT/IMPCHase bienzyme purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_1529382_2 519989.ECTPHS_09243 3.22e-27 104.0 COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,1WYH2@135613|Chromatiales 135613|Chromatiales M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins - - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD k59_1435589_1 378806.STAUR_8070 1.58e-14 75.9 COG0642@1|root,COG2205@2|Bacteria,1QX6V@1224|Proteobacteria,43BZK@68525|delta/epsilon subdivisions,2X7AC@28221|Deltaproteobacteria,2YYIJ@29|Myxococcales 28221|Deltaproteobacteria T GAF domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_4 k59_1435589_2 391165.GbCGDNIH1_1226 6.54e-123 375.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,2JPK4@204441|Rhodospirillales 204441|Rhodospirillales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains ntrC - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_967887_1 330214.NIDE4283 1.02e-112 339.0 COG0612@1|root,COG0612@2|Bacteria,3J0BY@40117|Nitrospirae 2|Bacteria S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology pqqL - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1074384_1 225849.swp_2110 1.6e-06 49.7 COG1757@1|root,COG1757@2|Bacteria,1MY5C@1224|Proteobacteria,1S1DJ@1236|Gammaproteobacteria,2QDCU@267890|Shewanellaceae 1236|Gammaproteobacteria C Na+/H+ antiporter family - - - - - - - - - - - - Na_H_antiporter k59_1074384_2 1121921.KB898707_gene1185 5.76e-64 205.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,2PNDR@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria O Leucyl/phenylalanyl-tRNA protein transferase aat GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_1020524_1 187272.Mlg_1810 3.53e-79 251.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1WW6E@135613|Chromatiales 135613|Chromatiales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_135992_2 558884.JRGM01000153_gene949 1.01e-08 57.0 COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,1RMQ1@1236|Gammaproteobacteria,1Y43X@135624|Aeromonadales 135624|Aeromonadales L DNA polymerase polB - 2.7.7.7 ko:K02336 - - - - ko00000,ko01000,ko03400 - - - DNA_pol_B,DNA_pol_B_exo1 k59_917815_2 1247726.MIM_c40410 1.02e-08 56.2 COG4261@1|root,COG4261@2|Bacteria,1R5JJ@1224|Proteobacteria,2WF1F@28216|Betaproteobacteria,3T9DC@506|Alcaligenaceae 28216|Betaproteobacteria S Bacterial lipid A biosynthesis acyltransferase - - - - - - - - - - - - Lip_A_acyltrans k59_1595022_1 511062.GU3_15910 2.46e-178 511.0 COG1167@1|root,COG1167@2|Bacteria,1MVGT@1224|Proteobacteria,1RPFK@1236|Gammaproteobacteria,1Y4I5@135624|Aeromonadales 135624|Aeromonadales K helix_turn_helix gluconate operon transcriptional repressor - - - ko:K00375 - - - - ko00000,ko03000 - - - Aminotran_1_2,GntR k59_1652211_1 1191523.MROS_2593 1.7e-14 79.3 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria 2|Bacteria M LysM domain CP_0155 - - ko:K08307,ko:K12204 - - - - ko00000,ko01000,ko01011,ko02044 3.A.7.10.1,3.A.7.9.1 - - LysM,SLT,T4SS_TraI k59_1330143_1 871963.Desdi_0961 1.37e-44 152.0 COG2197@1|root,COG2197@2|Bacteria,1TQ1U@1239|Firmicutes,24IAA@186801|Clostridia,26539@186807|Peptococcaceae 186801|Clostridia K PFAM Response regulator receiver domain - - - - - - - - - - - - GerE,Response_reg k59_1330143_2 261292.Nit79A3_2200 5.87e-06 49.7 COG3851@1|root,COG3851@2|Bacteria,1PETW@1224|Proteobacteria,2W8Z5@28216|Betaproteobacteria,373VY@32003|Nitrosomonadales 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07675 ko02020,map02020 M00473 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HisKA_3 k59_90949_3 314278.NB231_01294 4.32e-60 193.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1WX9S@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_238196_2 999541.bgla_1g20980 2.26e-44 154.0 COG0517@1|root,COG0517@2|Bacteria,1RE9W@1224|Proteobacteria,2VRIH@28216|Betaproteobacteria,1K4C0@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM CBS domain containing protein - - - - - - - - - - - - BON,CBS k59_1536383_2 748247.AZKH_2885 1.75e-56 184.0 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2VQ24@28216|Betaproteobacteria,2KW0K@206389|Rhodocyclales 206389|Rhodocyclales F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_1127976_1 1218103.CIN01S_12_00930 6.84e-38 140.0 COG1858@1|root,COG1858@2|Bacteria,4NEKS@976|Bacteroidetes,1HZT9@117743|Flavobacteriia,3ZRIM@59732|Chryseobacterium 976|Bacteroidetes P Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_292318_1 713586.KB900536_gene929 8.28e-61 213.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1WWH2@135613|Chromatiales 135613|Chromatiales L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA recB - 3.1.11.5,3.6.4.12 ko:K03582,ko:K16898 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_1653601_1 378806.STAUR_7207 4.72e-28 118.0 COG0840@1|root,COG4166@1|root,COG0840@2|Bacteria,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,43BXR@68525|delta/epsilon subdivisions,2X1YS@28221|Deltaproteobacteria,2YYSK@29|Myxococcales 28221|Deltaproteobacteria ENT Bacterial extracellular solute-binding proteins, family 5 Middle - - - - - - - - - - - - MCPsignal,SBP_bac_5 k59_181491_1 765912.Thimo_2930 3.17e-32 129.0 COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1WWHI@135613|Chromatiales 135613|Chromatiales S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - TPR_1,TPR_16,VWA_2 k59_1292837_1 231434.JQJH01000009_gene1132 7.57e-52 177.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2TR8S@28211|Alphaproteobacteria,3NA89@45404|Beijerinckiaceae 28211|Alphaproteobacteria E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_396502_1 1469245.JFBG01000061_gene2329 2.62e-41 146.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,1WVWE@135613|Chromatiales 135613|Chromatiales J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - 2.1.1.200 ko:K02533,ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_1445007_1 330214.NIDE3221 4.67e-47 164.0 COG3005@1|root,COG3005@2|Bacteria 2|Bacteria C denitrification pathway - - - - - - - - - - - - - k59_1536387_1 1229909.NSED_02700 1.98e-64 200.0 COG1547@1|root,arCOG03705@2157|Archaea,41SQ0@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF309) - - - ko:K09763 - - - - ko00000 - - - DUF309 k59_1536387_2 436308.Nmar_0535 1.2e-59 188.0 COG2004@1|root,arCOG04182@2157|Archaea,41SWI@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the eukaryotic ribosomal protein eS24 family - - - ko:K02974 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - - k59_1536387_3 436308.Nmar_0534 2.74e-08 50.1 COG1998@1|root,arCOG04183@2157|Archaea,41SWB@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the eukaryotic ribosomal protein eS31 family rps27ae - - ko:K02977 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011,ko04147 - - - Ribosomal_S27 k59_1021495_1 929713.NIASO_00035 2.12e-28 110.0 COG3437@1|root,COG3437@2|Bacteria,4NP14@976|Bacteroidetes,1ISQ7@117747|Sphingobacteriia 976|Bacteroidetes T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg,SpoIIE k59_137343_1 1297581.H919_10553 5.96e-79 248.0 COG1960@1|root,COG1960@2|Bacteria,1TSN3@1239|Firmicutes,4HB0T@91061|Bacilli,21WK8@150247|Anoxybacillus 91061|Bacilli I Acyl-CoA dehydrogenase, N-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1174747_1 56780.SYN_00100 1.4e-11 64.3 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase acdA2 - - ko:K09181 - - - - ko00000 - - iAF987.Gmet_2142 ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_1386468_1 1535422.ND16A_0226 3.59e-11 66.2 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,2Q6FA@267889|Colwelliaceae 1236|Gammaproteobacteria I Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed fadI GO:0003674,GO:0003824,GO:0003857,GO:0003988,GO:0004300,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033542,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_2806,iEcHS_1320.EcHS_A2493 Thiolase_C,Thiolase_N k59_1386468_2 555778.Hneap_0005 2.05e-12 65.1 COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,1T06D@1236|Gammaproteobacteria,1X2KZ@135613|Chromatiales 135613|Chromatiales S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_968923_1 215803.DB30_0830 1.24e-48 170.0 COG1090@1|root,COG4276@1|root,COG1090@2|Bacteria,COG4276@2|Bacteria,1MUB4@1224|Proteobacteria,42PQ2@68525|delta/epsilon subdivisions,2WK6V@28221|Deltaproteobacteria,2YUBK@29|Myxococcales 28221|Deltaproteobacteria S Domain of unknown function (DUF1731) - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase,Polyketide_cyc k59_1331052_1 225117.XP_009350065.1 7.31e-28 112.0 COG0099@1|root,KOG3311@2759|Eukaryota 2759|Eukaryota J rRNA binding - GO:0000313,GO:0000314,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005763,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0071840,GO:0098798,GO:0140053,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_1331052_2 498211.CJA_0722 2.44e-74 224.0 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,1S3Q2@1236|Gammaproteobacteria,1FH96@10|Cellvibrio 1236|Gammaproteobacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_1536406_1 1535287.JP74_22965 4.47e-57 187.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2TR57@28211|Alphaproteobacteria,3N64K@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_1292870_1 1182553.XP_007747129.1 1.33e-22 96.3 COG0043@1|root,2QR5I@2759|Eukaryota,38EAD@33154|Opisthokonta,3NZD5@4751|Fungi,3QRPN@4890|Ascomycota,20M2N@147545|Eurotiomycetes 4751|Fungi F Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites FDC1 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009698,GO:0009803,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0017144,GO:0018904,GO:0018958,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0033494,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046271,GO:0046281,GO:0046395,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615 4.1.1.102 ko:K20039 ko00940,map00940 - R02952,R03367 RC00814 ko00000,ko00001,ko01000 - - - UbiD k59_1128022_1 929712.KI912613_gene4946 4.58e-83 251.0 COG0087@1|root,COG0087@2|Bacteria,2GJXT@201174|Actinobacteria,4CPFD@84995|Rubrobacteria 84995|Rubrobacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_450260_1 272123.Anacy_2100 3.59e-43 160.0 COG2374@1|root,COG2931@1|root,COG2374@2|Bacteria,COG2931@2|Bacteria,1GQ21@1117|Cyanobacteria,1HJBD@1161|Nostocales 1117|Cyanobacteria L Belongs to the TPP enzyme family - - - ko:K07004 - - - - ko00000 - - - DUF3616,Exo_endo_phos,FG-GAP,HemolysinCabind,LTD k59_710319_1 316067.Geob_1502 1.9e-17 86.7 COG1629@1|root,COG4886@1|root,COG4771@2|Bacteria,COG4886@2|Bacteria 2|Bacteria S regulation of response to stimulus inlA - - ko:K02014,ko:K13730 ko05100,map05100 - - - ko00000,ko00001,ko02000 1.B.14 - - DUF285,FecR,LRR_4,Strep_his_triad,TPR_16 k59_1292878_1 1121405.dsmv_3810 6.97e-75 229.0 COG2842@1|root,COG2842@2|Bacteria,1Q491@1224|Proteobacteria,42YN2@68525|delta/epsilon subdivisions,2WTMU@28221|Deltaproteobacteria,2MMGY@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposition protein - - - - - - - - - - - - - k59_665927_1 268746.Q58MN3_BPPRM 2.1e-51 181.0 4QDJF@10239|Viruses,4QVQ0@35237|dsDNA viruses no RNA stage,4QR89@28883|Caudovirales,4QICF@10662|Myoviridae 10662|Myoviridae S Virus neck protein - GO:0005575,GO:0019012 - - - - - - - - - - - k59_1500419_1 330214.NIDE1317 7.73e-117 337.0 COG0092@1|root,COG0092@2|Bacteria,3J0AP@40117|Nitrospirae 40117|Nitrospirae J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_137382_1 765910.MARPU_09390 7.3e-38 146.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1WX5E@135613|Chromatiales 135613|Chromatiales M PFAM Lytic - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_181518_1 1142394.PSMK_27020 1.18e-48 171.0 COG1363@1|root,COG1363@2|Bacteria 2|Bacteria G aminopeptidase activity - - - - - - - - - - - - Peptidase_M28,Peptidase_M42 k59_292373_1 398527.Bphyt_2218 1.2e-05 51.6 COG0625@1|root,COG0625@2|Bacteria,1RA4M@1224|Proteobacteria,2VQHN@28216|Betaproteobacteria,1K7AA@119060|Burkholderiaceae 28216|Betaproteobacteria O Glutathione S-transferase, C-terminal domain - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_1500424_2 1229909.NSED_03070 2.19e-71 225.0 COG1253@1|root,arCOG00626@2157|Archaea 2157|Archaea S COG1253 Hemolysins and related proteins containing CBS domains cbs9 - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_344546_1 926550.CLDAP_10400 1.84e-34 129.0 COG1216@1|root,COG1216@2|Bacteria,2G7Y1@200795|Chloroflexi 200795|Chloroflexi M Glycosyl transferase family group 2 - - - - - - - - - - - - - k59_665934_1 502025.Hoch_4956 3.84e-87 270.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2WIZZ@28221|Deltaproteobacteria,2YU7R@29|Myxococcales 28221|Deltaproteobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_1445040_1 1479237.JMLY01000001_gene2146 7.82e-86 268.0 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,464VM@72275|Alteromonadaceae 1236|Gammaproteobacteria J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0050896,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_1536422_1 509635.N824_00860 4.84e-23 102.0 COG2114@1|root,COG2114@2|Bacteria,4NKWT@976|Bacteroidetes,1IV7B@117747|Sphingobacteriia 976|Bacteroidetes T Protein of unknown function (DUF2652) - - - - - - - - - - - - DUF2652 k59_1174776_1 1211815.CBYP010000063_gene1913 9.05e-95 292.0 COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria 201174|Actinobacteria I Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta - - - - - - - - - - - - Carboxyl_trans k59_1128048_1 1121405.dsmv_2496 4.26e-41 149.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,42MMB@68525|delta/epsilon subdivisions,2WJEI@28221|Deltaproteobacteria,2MIFI@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2910 ThiC_Rad_SAM k59_1653678_1 61273.S3CAZ4 2.17e-07 55.1 COG2072@1|root,KOG1399@2759|Eukaryota,38F9M@33154|Opisthokonta,3NYFY@4751|Fungi,3QMZI@4890|Ascomycota,215I7@147550|Sordariomycetes,3UV9B@5151|Ophiostomatales 4751|Fungi Q FAD-NAD(P)-binding - - - - - - - - - - - - FMO-like,NAD_binding_8 k59_292386_1 1123392.AQWL01000003_gene141 1.63e-30 117.0 COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,2VJGA@28216|Betaproteobacteria 28216|Betaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K21834 - - - - ko00000 - - - CCG,DUF3483,Fer4_8 k59_292386_2 1049564.TevJSym_bc00370 1.48e-33 123.0 COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1RRNM@1236|Gammaproteobacteria 1236|Gammaproteobacteria C nitrate reductase activity - - - - - - - - - - - - - k59_1386506_2 34839.XP_005382733.1 1.04e-07 56.2 COG1011@1|root,KOG3085@2759|Eukaryota,38CID@33154|Opisthokonta,3BJEU@33208|Metazoa,3CZ86@33213|Bilateria,47ZW9@7711|Chordata,496SZ@7742|Vertebrata,3J380@40674|Mammalia,35HSI@314146|Euarchontoglires,4Q4QN@9989|Rodentia 33208|Metazoa S HAD-hyrolase-like HDHD3 - - - - - - - - - - - HAD_2,Hydrolase k59_1500446_1 1238182.C882_1324 3.62e-50 165.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,2JWES@204441|Rhodospirillales 204441|Rhodospirillales L leucine-zipper of insertion element IS481 - - - - - - - - - - - - HTH_32 k59_1500446_2 693986.MOC_3624 6.09e-17 75.1 COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria,1JVFR@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_603710_1 330214.NIDE1671 4.74e-62 210.0 COG1297@1|root,COG1297@2|Bacteria 2|Bacteria S iron-nicotianamine transmembrane transporter activity oliA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - - - - - - - - - - OPT k59_137422_1 1244869.H261_09252 2.64e-32 125.0 COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,1MXK5@1224|Proteobacteria,2U13I@28211|Alphaproteobacteria,2JQVM@204441|Rhodospirillales 204441|Rhodospirillales S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - AMMECR1,Memo k59_1596036_1 1121875.KB907548_gene1637 5.26e-08 51.6 COG0664@1|root,COG0664@2|Bacteria,4NRPE@976|Bacteroidetes 976|Bacteroidetes T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_1021563_1 1487923.DP73_02825 9.19e-68 225.0 COG4865@1|root,COG4865@2|Bacteria,1TS6B@1239|Firmicutes,24AYE@186801|Clostridia,2610W@186807|Peptococcaceae 186801|Clostridia E Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate) glmE - 5.4.99.1 ko:K19268 ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200 M00740 R00262 RC01221 ko00000,ko00001,ko00002,ko01000 - - - Met_asp_mut_E k59_1596051_1 1236541.BALL01000034_gene3512 1.74e-07 52.4 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,1RRDV@1236|Gammaproteobacteria,2QAEA@267890|Shewanellaceae 1236|Gammaproteobacteria P TIGRFAM molybdate ABC transporter, inner membrane subunit - - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_1596051_2 1454004.AW11_02773 4.23e-23 97.4 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2VJEC@28216|Betaproteobacteria,1KQVI@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P Bacterial extracellular solute-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_181564_1 1129794.C427_4036 2.15e-34 132.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,46442@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_1653739_1 402881.Plav_3246 3.44e-41 152.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,2TU0C@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - ko:K03319,ko:K09477,ko:K11106,ko:K14445 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.47,2.A.47.1,2.A.47.3.2,2.A.47.3.3 - - Na_sulph_symp k59_1021577_1 648996.Theam_0254 1.15e-155 459.0 COG0480@1|root,COG0480@2|Bacteria,2G3NW@200783|Aquificae 200783|Aquificae J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1075928_1 388467.A19Y_3814 1.45e-33 133.0 COG0841@1|root,COG0841@2|Bacteria,1G0C2@1117|Cyanobacteria,1H8BN@1150|Oscillatoriales 1117|Cyanobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_137465_1 861299.J421_3598 4.22e-62 203.0 COG1071@1|root,COG1071@2|Bacteria,1ZT5G@142182|Gemmatimonadetes 2|Bacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) bfmBA - 1.2.4.1,1.2.4.4 ko:K00161,ko:K11381,ko:K21416 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_919465_1 203122.Sde_1148 3.32e-17 82.0 COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,4658U@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG3267 Type II secretory pathway, component ExeA gspA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_834125_1 1442599.JAAN01000030_gene2146 1.41e-56 195.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1X4Q2@135614|Xanthomonadales 135614|Xanthomonadales S transporter oliA - - - - - - - - - - - OPT k59_834125_2 641491.DND132_2893 1.66e-13 65.1 2AKB0@1|root,31B1Q@2|Bacteria,1Q6QF@1224|Proteobacteria,432VH@68525|delta/epsilon subdivisions,2WX9F@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Phospholipase_D-nuclease N-terminal - - - - - - - - - - - - PLDc_N k59_188585_1 101028.EKJ74541 4.14e-16 84.0 2CXQ1@1|root,2RYZR@2759|Eukaryota,39T0P@33154|Opisthokonta,3NWV2@4751|Fungi,3QSG7@4890|Ascomycota,218N3@147550|Sordariomycetes,3TDDS@5125|Hypocreales,1FPW5@110618|Nectriaceae 4751|Fungi G Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_976838_1 40373.F991_01310 3.65e-46 158.0 COG1225@1|root,COG1225@2|Bacteria,1RH4P@1224|Proteobacteria,1SBKN@1236|Gammaproteobacteria,3NM03@468|Moraxellaceae 1236|Gammaproteobacteria O Redoxin - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_834127_2 519989.ECTPHS_07087 1.06e-48 157.0 COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,1S6FN@1236|Gammaproteobacteria,1WYHG@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_834127_3 1123368.AUIS01000012_gene758 4.63e-155 456.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,2NCR4@225057|Acidithiobacillales 225057|Acidithiobacillales CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_301230_1 525909.Afer_0493 1.05e-55 196.0 COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4CMSA@84992|Acidimicrobiia 84992|Acidimicrobiia E Peptidase family M1 domain - - - ko:K08776 - - - - ko00000,ko01000,ko01002 - - - ERAP1_C,Peptidase_M1 k59_559237_1 1380394.JADL01000001_gene2346 7.32e-11 62.0 COG1028@1|root,COG1028@2|Bacteria,1QWBB@1224|Proteobacteria,2U2FD@28211|Alphaproteobacteria,2JVVT@204441|Rhodospirillales 204441|Rhodospirillales IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_928276_1 448385.sce3594 1.22e-18 91.7 COG1413@1|root,COG3119@1|root,COG1413@2|Bacteria,COG3119@2|Bacteria,1MWY7@1224|Proteobacteria,42V1G@68525|delta/epsilon subdivisions,2WRCZ@28221|Deltaproteobacteria,2YWCA@29|Myxococcales 28221|Deltaproteobacteria P Sulfatase - - - - - - - - - - - - Sulfatase k59_1543524_1 743299.Acife_2888 1.07e-44 152.0 COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,1RMUT@1236|Gammaproteobacteria,2NCNK@225057|Acidithiobacillales 225057|Acidithiobacillales H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth k59_1543524_2 314278.NB231_08848 6.05e-34 123.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,1WYF6@135613|Chromatiales 135613|Chromatiales S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - - - - - - - - - - Hexapep k59_1303993_1 983545.Glaag_2177 2.33e-05 47.4 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,466GX@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases anr - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_353358_1 313612.L8106_29230 7.24e-31 111.0 COG3288@1|root,COG3288@2|Bacteria,1G711@1117|Cyanobacteria,1HBSJ@1150|Oscillatoriales 1117|Cyanobacteria C NAD NADP transhydrogenase alpha subunit pntA-2 - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB_4TM k59_353358_2 78345.BMERY_0323 4.5e-05 46.6 COG1282@1|root,COG1282@2|Bacteria,2GNKB@201174|Actinobacteria,4CZF5@85004|Bifidobacteriales 201174|Actinobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_17829_1 483219.LILAB_03820 1.03e-64 204.0 COG1595@1|root,COG1595@2|Bacteria,1RBM4@1224|Proteobacteria,42S7N@68525|delta/epsilon subdivisions,2X3DW@28221|Deltaproteobacteria,2YUWD@29|Myxococcales 28221|Deltaproteobacteria K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_188612_1 861299.J421_3522 3.74e-64 219.0 COG0013@1|root,COG0013@2|Bacteria,1ZT18@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_928290_1 1118060.CAGZ01000023_gene757 7.76e-49 167.0 COG0275@1|root,COG0275@2|Bacteria,2GJGK@201174|Actinobacteria,4CUEV@84998|Coriobacteriia 84998|Coriobacteriia J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_301258_1 289376.THEYE_A0247 4.31e-71 226.0 COG0126@1|root,COG0126@2|Bacteria,3J0DE@40117|Nitrospirae 40117|Nitrospirae G Phosphoglycerate kinase pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_246305_1 402881.Plav_0392 4.37e-166 476.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria,1JNZ3@119043|Rhodobiaceae 28211|Alphaproteobacteria C Acyl-CoA dehydrogenase type 2 domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1304030_1 395494.Galf_0769 2.98e-95 291.0 COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,2VHXU@28216|Betaproteobacteria,44WAP@713636|Nitrosomonadales 28216|Betaproteobacteria C PFAM cytochrome c oxidase subunit I norB - 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - COX1 k59_718348_1 4641.GSMUA_Achr8P15520_001 1.74e-54 182.0 COG3733@1|root,KOG1186@2759|Eukaryota,37PUP@33090|Viridiplantae,3GC4I@35493|Streptophyta,3KNHY@4447|Liliopsida 35493|Streptophyta Q Belongs to the copper topaquinone oxidase family - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0016491,GO:0016638,GO:0016641,GO:0042221,GO:0050896,GO:0051716,GO:0052597,GO:0055114,GO:0070887,GO:0071241,GO:0097184,GO:0097185,GO:1901698,GO:1901699 1.4.3.21 ko:K00276 ko00260,ko00350,ko00360,ko00410,ko00950,ko00960,ko01100,ko01110,map00260,map00350,map00360,map00410,map00950,map00960,map01100,map01110 - R02382,R02529,R02613,R03139,R04027,R04300,R06154,R06740 RC00062,RC00189,RC00676,RC01052 ko00000,ko00001,ko01000 - - - Cu_amine_oxid,Cu_amine_oxidN2,Cu_amine_oxidN3 k59_1451937_1 95619.PM1_0203335 1.13e-36 134.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0031119,GO:0034337,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_1084835_1 1469245.JFBG01000046_gene2257 1.44e-173 503.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Dehydrogenase xoxF - 1.1.2.8 ko:K00114 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - PQQ k59_403764_1 1249627.D779_2197 1.57e-104 327.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales 135613|Chromatiales O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_834219_1 1038859.AXAU01000003_gene6187 8.21e-117 361.0 COG0845@1|root,COG3409@1|root,COG0845@2|Bacteria,COG3409@2|Bacteria 2|Bacteria M Peptidoglycan-binding domain 1 protein - - 3.2.1.35 ko:K01197,ko:K02022 ko00531,ko01100,map00531,map01100 M00076,M00077 R07824,R07825,R10905 - ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042 - - - Biotin_lipoyl_2,HlyD_3,PG_binding_1,YkuD k59_1338020_1 436308.Nmar_1234 6.9e-107 317.0 COG0489@1|root,arCOG01846@1|root,arCOG00585@2157|Archaea,arCOG01846@2157|Archaea,41SF1@651137|Thaumarchaeota 651137|Thaumarchaeota D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_1393421_1 1468179.A0A0C4K552_9VIRU 1.82e-59 188.0 4QAR6@10239|Viruses 10239|Viruses L dUTP diphosphatase activity - GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003964,GO:0004175,GO:0004190,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0006139,GO:0006259,GO:0006278,GO:0006308,GO:0006412,GO:0006414,GO:0006417,GO:0006451,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008907,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0015074,GO:0016032,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0018995,GO:0019012,GO:0019058,GO:0019080,GO:0019081,GO:0019222,GO:0019438,GO:0019439,GO:0019538,GO:0020002,GO:0030430,GO:0031323,GO:0031326,GO:0032268,GO:0032991,GO:0032993,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0034061,GO:0034248,GO:0034641,GO:0034645,GO:0034654,GO:0034655,GO:0039705,GO:0042802,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043656,GO:0043657,GO:0044174,GO:0044184,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044279,GO:0044403,GO:0044419,GO:0044823,GO:0044824,GO:0044826,GO:0046483,GO:0046700,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0051704,GO:0060255,GO:0065007,GO:0070001,GO:0070011,GO:0071704,GO:0071897,GO:0072494,GO:0080090,GO:0090304,GO:0090305,GO:0097159,GO:0140096,GO:0140097,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:2000112 - - - - - - - - - - - k59_1244754_1 926564.KI911744_gene3711 1.51e-40 141.0 COG2080@1|root,COG2080@2|Bacteria,2GMYH@201174|Actinobacteria 201174|Actinobacteria C Aerobic-type carbon monoxide dehydrogenase small subunit CoxS - - - ko:K13483 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002 - - - Fer2,Fer2_2 k59_834238_1 926550.CLDAP_10160 4.72e-60 200.0 COG0399@1|root,COG0399@2|Bacteria,2G7WW@200795|Chloroflexi 200795|Chloroflexi E DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_1029331_1 1300345.LF41_223 5.39e-71 222.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,1X4CF@135614|Xanthomonadales 135614|Xanthomonadales I Catalyzes a key regulatory step in fatty acid biosynthesis - - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1511618_1 666681.M301_1211 1.66e-07 58.5 COG3746@1|root,COG3746@2|Bacteria,1MY3M@1224|Proteobacteria,2VIIP@28216|Betaproteobacteria 28216|Betaproteobacteria P phosphate-selective porin O and P - - - - - - - - - - - - - k59_1181809_1 419665.Maeo_1464 4.16e-05 47.8 COG0009@1|root,arCOG01952@2157|Archaea,2XVGC@28890|Euryarchaeota,23QSE@183939|Methanococci 183939|Methanococci J TIGRFAM Sua5 YciO YrdC YwlC family protein - - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - SUA5,Sua5_yciO_yrdC k59_1181809_2 644282.Deba_1365 1.09e-21 93.2 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WJY0@28221|Deltaproteobacteria 28221|Deltaproteobacteria F PFAM SAICAR synthetase purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_559323_1 400682.PAC_15710330 5.31e-192 542.0 COG0372@1|root,KOG2617@2759|Eukaryota,38E3U@33154|Opisthokonta,3BNEP@33208|Metazoa 33208|Metazoa C Citrate synthase, C-terminal domain - - - - - - - - - - - - Citrate_synt k59_403804_1 1458275.AZ34_07525 1.55e-81 251.0 COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,2VIZ9@28216|Betaproteobacteria,4AARP@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1365) - - - ko:K09701 - - - - ko00000 - - - DUF1365 k59_677147_2 1355374.JARU01000001_gene96 1.84e-21 91.3 COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,42RHI@68525|delta/epsilon subdivisions,2YNYI@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F MafB19-like deaminase - - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_458699_1 720554.Clocl_4214 1.69e-76 247.0 COG0029@1|root,COG0029@2|Bacteria,1UHSP@1239|Firmicutes,25E6F@186801|Clostridia,3WGEV@541000|Ruminococcaceae 186801|Clostridia H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1393443_1 1202768.JROF01000016_gene1336 5.72e-34 131.0 COG0318@1|root,arCOG00856@2157|Archaea,2XST5@28890|Euryarchaeota,23SBA@183963|Halobacteria 183963|Halobacteria I COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II menE - 6.2.1.26 ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C k59_834276_1 349124.Hhal_0025 3.4e-110 332.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1WWB4@135613|Chromatiales 135613|Chromatiales C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_518220_1 751994.AGIG01000034_gene609 0.000253 43.5 COG3751@1|root,COG3751@2|Bacteria,1R1Q5@1224|Proteobacteria,1T0QR@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Putative 2OG-Fe(II) oxygenase - - - - - - - - - - - - 2OG-FeII_Oxy_5 k59_518220_2 266265.Bxe_B0219 2.41e-15 77.0 COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,2VJHT@28216|Betaproteobacteria,1K2A6@119060|Burkholderiaceae 28216|Betaproteobacteria S PKHD-type hydroxylase piuC - - ko:K07336 - - - - ko00000,ko01000 - - - 2OG-FeII_Oxy_3 k59_458708_2 69042.WH5701_15971 1.48e-28 107.0 COG1225@1|root,COG1225@2|Bacteria,1G6AA@1117|Cyanobacteria,1H09N@1129|Synechococcus 1117|Cyanobacteria O Bacterioferritin comigratory bcp - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_518232_1 589865.DaAHT2_0447 2.01e-35 136.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,2MI03@213118|Desulfobacterales 28221|Deltaproteobacteria EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657,ko:K13503 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_188706_1 857087.Metme_1105 3.36e-17 84.3 COG0583@1|root,COG0583@2|Bacteria,1PX1B@1224|Proteobacteria,1SYEI@1236|Gammaproteobacteria,1XFC8@135618|Methylococcales 135618|Methylococcales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_928381_1 313606.M23134_02572 5.63e-54 182.0 COG1219@1|root,COG1219@2|Bacteria,4NE1B@976|Bacteroidetes,47JDR@768503|Cytophagia 2|Bacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP - - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small k59_610786_1 330214.NIDE4150 1.05e-120 367.0 COG1413@1|root,COG1413@2|Bacteria,3J1E2@40117|Nitrospirae 40117|Nitrospirae C Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - HEAT_2,HEAT_PBS k59_189751_3 382464.ABSI01000010_gene3403 3.24e-09 59.3 COG1595@1|root,COG1595@2|Bacteria,46SZG@74201|Verrucomicrobia,2IUFS@203494|Verrucomicrobiae 203494|Verrucomicrobiae K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1544678_1 999141.GME_06634 4.57e-21 92.4 COG0111@1|root,COG0111@2|Bacteria,1N5TD@1224|Proteobacteria,1RMFW@1236|Gammaproteobacteria,1XHAR@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate pdxB - 1.1.1.290 ko:K03473 ko00750,ko01100,map00750,map01100 M00124 R04210 RC00084 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C,DUF3410 k59_1544678_2 105559.Nwat_2195 3.48e-28 110.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1WX0P@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_1513017_1 330214.NIDE3073 2.03e-45 148.0 COG0228@1|root,COG0228@2|Bacteria,3J0UI@40117|Nitrospirae 40117|Nitrospirae J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_1666449_1 713586.KB900536_gene2525 5.69e-68 216.0 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales 135613|Chromatiales P Belongs to the sulfate adenylyltransferase family sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_1305630_1 713587.THITH_12015 3.28e-146 425.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria,1WXQI@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_8 k59_1452915_1 1116472.MGMO_111c00220 6.02e-37 127.0 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,1XFF2@135618|Methylococcales 135618|Methylococcales C Belongs to the glutaredoxin family. Monothiol subfamily - - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin k59_1513045_2 1279015.KB908463_gene2074 1.72e-24 104.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1Y3PZ@135624|Aeromonadales 135624|Aeromonadales O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_1137937_1 1041146.ATZB01000008_gene2192 6.49e-51 179.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_768859_2 1408444.JHYC01000007_gene2293 1.09e-173 501.0 COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,1RY9G@1236|Gammaproteobacteria,1JE37@118969|Legionellales 118969|Legionellales C Aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1394318_1 436308.Nmar_0839 1.7e-46 158.0 COG2263@1|root,arCOG00910@2157|Archaea,41S85@651137|Thaumarchaeota 651137|Thaumarchaeota J RNA methylase - - - - - - - - - - - - - k59_1394318_2 436308.Nmar_0562 5.68e-05 43.9 arCOG11721@1|root,arCOG11721@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1513046_1 1232410.KI421421_gene3417 7.69e-84 256.0 COG0767@1|root,COG0767@2|Bacteria,1RHNJ@1224|Proteobacteria,42SNW@68525|delta/epsilon subdivisions,2WPKT@28221|Deltaproteobacteria,43T2D@69541|Desulfuromonadales 28221|Deltaproteobacteria Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_1513046_2 760142.Hipma_1574 3.24e-10 61.6 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NI4@68525|delta/epsilon subdivisions,2WKRT@28221|Deltaproteobacteria,2M6MG@213113|Desulfurellales 28221|Deltaproteobacteria Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_362638_1 551789.ATVJ01000002_gene2664 2.98e-13 72.0 COG1024@1|root,COG1024@2|Bacteria,1N4N7@1224|Proteobacteria,2TS6T@28211|Alphaproteobacteria,43W80@69657|Hyphomonadaceae 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_621164_1 1380394.JADL01000002_gene1197 3.85e-66 222.0 COG3387@1|root,COG3387@2|Bacteria,1MYVI@1224|Proteobacteria,2TVIW@28211|Alphaproteobacteria,2JVYZ@204441|Rhodospirillales 204441|Rhodospirillales G Glucodextranase, domain N - - - - - - - - - - - - Glucodextran_N,Glyco_hydro_15 k59_984805_1 1216966.BAUC01000004_gene2097 3.94e-12 65.5 COG0131@1|root,COG0241@1|root,COG0131@2|Bacteria,COG0241@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Histidine biosynthesis bifunctional protein HisB hisB GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 ko:K01089,ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013,R03457 RC00017,RC00932 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iUMNK88_1353.UMNK88_2570 Hydrolase_like,IGPD,PNK3P k59_984805_2 908612.HMPREF9720_1356 1.64e-15 79.0 COG0079@1|root,COG0079@2|Bacteria,4NEDI@976|Bacteroidetes,2FMFQ@200643|Bacteroidia,22USX@171550|Rikenellaceae 976|Bacteroidetes E Aminotransferase class I and II hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_199133_1 1168065.DOK_09429 4.21e-13 74.7 COG2931@1|root,COG4886@1|root,COG2931@2|Bacteria,COG4886@2|Bacteria 2|Bacteria S regulation of response to stimulus inlA - 3.4.24.40 ko:K01406,ko:K13730 ko01503,ko05100,map01503,map05100 - - - ko00000,ko00001,ko01000,ko01002 - - - LRR_4,Strep_his_triad k59_1461102_1 204773.HEAR0899 5.16e-28 114.0 COG0457@1|root,COG0457@2|Bacteria,1Q84V@1224|Proteobacteria,2VJAQ@28216|Betaproteobacteria,472TC@75682|Oxalobacteraceae 28216|Betaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - DUF4440,TPR_11,TPR_16,TPR_17,TPR_19,TPR_8 k59_1094451_1 28229.ND2E_3483 1.47e-46 170.0 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RNFK@1236|Gammaproteobacteria,2Q80K@267889|Colwelliaceae 1236|Gammaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - 2.7.13.3 ko:K07641 ko02020,map02020 M00449 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_567905_1 504487.JCM19302_1963 7.87e-31 121.0 COG0598@1|root,COG0598@2|Bacteria,4NG3C@976|Bacteroidetes,1HXRX@117743|Flavobacteriia 976|Bacteroidetes P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_199144_1 436308.Nmar_1004 1.98e-22 95.9 COG0405@1|root,arCOG04053@2157|Archaea 2157|Archaea E gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_362672_1 1120971.AUCA01000049_gene794 2.29e-50 175.0 COG1783@1|root,COG1783@2|Bacteria,1VK0H@1239|Firmicutes,4HQ2H@91061|Bacilli 91061|Bacilli S Terminase-like family - - - - - - - - - - - - Terminase_6,Terminase_6C k59_362673_1 706587.Desti_5255 1.53e-40 151.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2MR5Q@213462|Syntrophobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_414082_1 383372.Rcas_4052 2.59e-115 364.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,2G5M1@200795|Chloroflexi,376VN@32061|Chloroflexia 32061|Chloroflexia C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1402542_1 349521.HCH_05350 2.26e-49 162.0 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,1S6BS@1236|Gammaproteobacteria,1XJZW@135619|Oceanospirillales 135619|Oceanospirillales J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_1402542_2 1500894.JQNN01000001_gene2914 1.22e-23 99.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,2VIU8@28216|Betaproteobacteria,4727R@75682|Oxalobacteraceae 28216|Betaproteobacteria P Mg2 and Co2 transporter corC - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_1553623_1 1216007.AOPM01000059_gene1733 7.51e-45 166.0 COG4122@1|root,COG4122@2|Bacteria,1QWCT@1224|Proteobacteria,1T2U3@1236|Gammaproteobacteria,2Q1IC@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S O-methyltransferase activity - - - - - - - - - - - - - k59_1147956_1 2340.JV46_11730 1.61e-38 133.0 COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,1S9D9@1236|Gammaproteobacteria,1J6NQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases hit1 - - - - - - - - - - - HIT k59_1147956_2 1453501.JELR01000001_gene1818 2.2e-14 72.0 2E80T@1|root,332F0@2|Bacteria,1N7RY@1224|Proteobacteria,1SCE8@1236|Gammaproteobacteria,467UH@72275|Alteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4389) - - - - - - - - - - - - DUF4389 k59_468455_1 289376.THEYE_A1821 7.62e-37 126.0 COG4274@1|root,COG4274@2|Bacteria 2|Bacteria S GYD domain - - - - - - - - - - - - GYD k59_199200_1 1297742.A176_00604 6.46e-29 114.0 COG3338@1|root,COG3338@2|Bacteria,1PEA6@1224|Proteobacteria,42RBG@68525|delta/epsilon subdivisions 1224|Proteobacteria P carbonic anhydrase cah - 4.2.1.1 ko:K01674 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Carb_anhydrase k59_727034_1 444860.E3SJ39_9CAUD 5.29e-45 147.0 4QBC7@10239|Viruses,4QUQW@35237|dsDNA viruses no RNA stage,4QPGT@28883|Caudovirales,4QIH8@10662|Myoviridae 10662|Myoviridae S Pfam:Phage_clamp_A - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_1147972_1 436308.Nmar_0847 3.8e-19 82.0 COG0041@1|root,arCOG02464@2157|Archaea,41SN4@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_1147972_2 436308.Nmar_0846 1.1e-52 176.0 COG0026@1|root,arCOG01597@2157|Archaea,41SD9@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_1402607_1 1379270.AUXF01000004_gene3004 2.2e-65 214.0 COG2805@1|root,COG2805@2|Bacteria,1ZT2Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_727062_1 1163617.SCD_n00294 1.9e-82 245.0 COG0346@1|root,COG0346@2|Bacteria,1N116@1224|Proteobacteria,2VRA3@28216|Betaproteobacteria 28216|Betaproteobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - ko:K07032 - - - - ko00000 - - - Glyoxalase k59_362766_1 1117647.M5M_13020 2.93e-31 124.0 COG0845@1|root,COG0845@2|Bacteria,1MV1T@1224|Proteobacteria,1RQTS@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3,HlyD_D23 k59_621320_1 637389.Acaty_c2687 5.97e-16 75.1 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,1RQ0Y@1236|Gammaproteobacteria,2NCX9@225057|Acidithiobacillales 225057|Acidithiobacillales Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_621320_2 159450.NH14_22640 3.19e-53 182.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria,1K1I1@119060|Burkholderiaceae 28216|Betaproteobacteria M PFAM VacJ family lipoprotein vacJ - - ko:K04754 - - - - ko00000 - - - MlaA k59_984973_1 1121430.JMLG01000009_gene439 3.28e-90 278.0 COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,2600A@186807|Peptococcaceae 186801|Clostridia G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_777160_1 1089551.KE386572_gene3782 2.1e-95 298.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TXAW@28211|Alphaproteobacteria,4BS2F@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_256042_1 444878.E3SQS8_9CAUD 0.000742 47.8 4QDE1@10239|Viruses,4QY7B@35237|dsDNA viruses no RNA stage,4QSAX@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_469718_1 1123368.AUIS01000021_gene992 7.37e-82 251.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,2NCRX@225057|Acidithiobacillales 225057|Acidithiobacillales K Belongs to the ParB family - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_1192658_2 1229909.NSED_03430 1.31e-84 266.0 COG0155@1|root,arCOG02055@2157|Archaea,41S5Q@651137|Thaumarchaeota 651137|Thaumarchaeota C Sulfite reductase - - 1.8.7.1 ko:K00392 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00859,R03600 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_882584_1 2340.JV46_02820 7.47e-139 402.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1J4PA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC GO:0003674,GO:0003824,GO:0004648,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006520,GO:0006553,GO:0006563,GO:0006564,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046394,GO:0046451,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901615,GO:1901617 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - iEcE24377_1341.EcE24377A_1004,iPC815.YPO1389,iYL1228.KPN_00935 Aminotran_5 k59_469726_1 330214.NIDE3057 6.63e-64 211.0 COG4122@1|root,COG4122@2|Bacteria 2|Bacteria E O-methyltransferase activity dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119,6.3.1.19 ko:K13571,ko:K20814 - M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 - - - Pup_ligase k59_1555055_1 1229780.BN381_80295 1.01e-37 144.0 COG0208@1|root,COG0208@2|Bacteria,2GJKZ@201174|Actinobacteria 201174|Actinobacteria F P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_882586_1 13037.EHJ72961 5.79e-22 96.3 COG0151@1|root,COG0299@1|root,KOG0237@2759|Eukaryota,KOG3076@2759|Eukaryota,38BPB@33154|Opisthokonta,3BDXA@33208|Metazoa,3CXAA@33213|Bilateria,41VJ7@6656|Arthropoda,3SGZ3@50557|Insecta,442PG@7088|Lepidoptera 33208|Metazoa F It is involved in the biological process described with purine nucleobase biosynthetic process GART GO:0001505,GO:0003674,GO:0003824,GO:0004637,GO:0004641,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006144,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006544,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006760,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009069,GO:0009108,GO:0009112,GO:0009113,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009396,GO:0009987,GO:0010033,GO:0010035,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0034641,GO:0034654,GO:0042133,GO:0042221,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046112,GO:0046148,GO:0046390,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0065007,GO:0065008,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.1.2.2,6.3.3.1,6.3.4.13 ko:K11787 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R04144,R04208,R04325,R04326 RC00026,RC00090,RC00166,RC00197,RC01100,RC01128 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,Formyl_trans_N,GARS_A,GARS_C,GARS_N k59_1404187_1 264462.Bd3787 9.73e-22 97.4 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,42NJ0@68525|delta/epsilon subdivisions,2MSVZ@213481|Bdellovibrionales,2WJ7A@28221|Deltaproteobacteria 213481|Bdellovibrionales M SMART PDZ DHR GLGF domain protein rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_1404187_2 1329516.JPST01000063_gene1793 3.61e-70 226.0 COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,4HBAV@91061|Bacilli,27B62@186824|Thermoactinomycetaceae 91061|Bacilli I 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_569071_1 522306.CAP2UW1_1738 5.3e-80 250.0 COG3385@1|root,COG3385@2|Bacteria,1R9HB@1224|Proteobacteria,2VMI8@28216|Betaproteobacteria 28216|Betaproteobacteria L Transposase IS4 family - - - - - - - - - - - - DDE_Tnp_1 k59_415534_1 1033806.HTIA_2463 8.59e-30 115.0 arCOG02703@1|root,arCOG02703@2157|Archaea,2XV0I@28890|Euryarchaeota,23SUR@183963|Halobacteria 183963|Halobacteria Q Methyltransferase type 11 aknG - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_415534_2 260799.BAS3107 1.83e-24 95.9 COG2076@1|root,COG2076@2|Bacteria,1VEUF@1239|Firmicutes,4HNJX@91061|Bacilli,1ZHWT@1386|Bacillus 91061|Bacilli P Small Multidrug Resistance protein yvaE - - ko:K03297 - - - - ko00000,ko02000 2.A.7.1 - - Multi_Drug_Res k59_364087_1 1121935.AQXX01000078_gene1573 1.38e-18 90.1 COG0840@1|root,COG0840@2|Bacteria,1QTXI@1224|Proteobacteria,1T42G@1236|Gammaproteobacteria,1XNJN@135619|Oceanospirillales 135619|Oceanospirillales NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - - - - - - - - - - MCPsignal k59_1192681_1 393595.ABO_1389 1.19e-17 81.6 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1XHG7@135619|Oceanospirillales 135619|Oceanospirillales D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_1192681_2 519989.ECTPHS_05325 2.15e-152 439.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1WW43@135613|Chromatiales 135613|Chromatiales J TIGRFAM Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_939442_1 1229909.NSED_04250 6.47e-99 304.0 COG0168@1|root,COG0517@1|root,arCOG00606@2157|Archaea,arCOG04145@2157|Archaea,41SZ8@651137|Thaumarchaeota 651137|Thaumarchaeota P CBS domain - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - CBS,TrkH k59_1095882_1 867903.ThesuDRAFT_02188 7.52e-25 102.0 COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,3WD0V@538999|Clostridiales incertae sedis 186801|Clostridia H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_1095882_2 269799.Gmet_1643 1.17e-48 164.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,42N3J@68525|delta/epsilon subdivisions,2WJ19@28221|Deltaproteobacteria,43UFX@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_22515_2 1304275.C41B8_10283 1.81e-05 47.4 COG2891@1|root,COG2891@2|Bacteria 2|Bacteria M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins mreD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD k59_469749_1 1173749.S4TRC9_9CAUD 2.29e-57 201.0 4QAKZ@10239|Viruses,4QYAE@35237|dsDNA viruses no RNA stage,4QPYH@28883|Caudovirales,4QM57@10699|Siphoviridae 10699|Siphoviridae S intein-mediated protein splicing - - - - - - - - - - - - - k59_939450_1 765913.ThidrDRAFT_2659 3.05e-86 260.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,1RPU6@1236|Gammaproteobacteria,1WWMH@135613|Chromatiales 135613|Chromatiales C PFAM Cytochrome C oxidase, monoheme subunit FixO - - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_939450_2 1168067.JAGP01000001_gene1939 1.25e-11 64.7 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,460AT@72273|Thiotrichales 72273|Thiotrichales C Belongs to the heme-copper respiratory oxidase family - - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_1610689_2 1047013.AQSP01000059_gene2096 6.24e-23 94.0 COG0736@1|root,COG0736@2|Bacteria,2NPTD@2323|unclassified Bacteria 2|Bacteria I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7,4.2.1.136 ko:K00997,ko:K17758 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS,Carb_kinase k59_1610689_3 105559.Nwat_1079 1.92e-84 264.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1WX2I@135613|Chromatiales 135613|Chromatiales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_1095888_1 1177154.Y5S_00554 6.36e-119 353.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria 1236|Gammaproteobacteria V ABC-type multidrug transport system, permease component - - - - - - - - - - - - ABC2_membrane,ABC2_membrane_3 k59_256079_1 203908.EGG06402 3.58e-06 52.8 COG0169@1|root,KOG0692@2759|Eukaryota,38GV4@33154|Opisthokonta,3NTWM@4751|Fungi,3UZM0@5204|Basidiomycota,2YCHJ@29000|Pucciniomycotina 4751|Fungi E The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis - GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 1.1.1.25,2.5.1.19,2.7.1.71,4.2.1.10,4.2.3.4 ko:K13830 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R02413,R03083,R03084,R03460 RC00002,RC00078,RC00206,RC00350,RC00847,RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,DHquinase_I,EPSP_synthase,SKI,Shikimate_DH,Shikimate_dh_N k59_256079_2 351607.Acel_1234 1.85e-10 60.5 COG0283@1|root,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,4ESQY@85013|Frankiales 201174|Actinobacteria F Belongs to the cytidylate kinase family. Type 1 subfamily cmk - 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Acyltransferase,Cytidylate_kin k59_469762_1 690850.Desaf_2460 6.75e-76 244.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,42MPG@68525|delta/epsilon subdivisions,2WKW8@28221|Deltaproteobacteria,2M9KT@213115|Desulfovibrionales 28221|Deltaproteobacteria HJ Belongs to the D-alanine--D-alanine ligase family - - - - - - - - - - - - Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK k59_1404234_1 391625.PPSIR1_09630 2.68e-07 57.8 COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,1MWVZ@1224|Proteobacteria,438G1@68525|delta/epsilon subdivisions,2X3QZ@28221|Deltaproteobacteria,2YWVV@29|Myxococcales 28221|Deltaproteobacteria KLT Serine Threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,PEGA,Pkinase,TPR_12 k59_1192719_1 436308.Nmar_1792 2.98e-104 317.0 COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota 651137|Thaumarchaeota O PFAM TCP-1 cpn60 chaperonin family - - - ko:K22447 - - - - ko00000,ko03110 - - - Cpn60_TCP1 k59_569107_1 1123320.KB889730_gene5900 5.85e-23 95.9 2BZRD@1|root,3441V@2|Bacteria,2IGGG@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - SnoaL_2 k59_1610714_1 1333998.M2A_0922 1.01e-91 289.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TQWP@28211|Alphaproteobacteria,4BPPR@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Gamma-glutamyltranspeptidase ywrD - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_622729_1 42256.RradSPS_1241 4.17e-66 210.0 COG0388@1|root,COG0388@2|Bacteria,2GMQA@201174|Actinobacteria,4CPAW@84995|Rubrobacteria 84995|Rubrobacteria S Carbon-nitrogen hydrolase - - - ko:K11206 - - - - ko00000,ko01000 - - - CN_hydrolase k59_986369_1 335284.Pcryo_0475 2.62e-66 219.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,3NIRM@468|Moraxellaceae 1236|Gammaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_469797_1 272942.RCAP_rcc01133 3.55e-39 144.0 COG4531@1|root,COG4531@2|Bacteria,1QTTI@1224|Proteobacteria,2TVXP@28211|Alphaproteobacteria,1FBPM@1060|Rhodobacter 28211|Alphaproteobacteria P Zinc-uptake complex component A periplasmic znuA - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_680477_1 584708.Apau_1634 3e-05 43.9 COG0255@1|root,COG0255@2|Bacteria,3TBNK@508458|Synergistetes 508458|Synergistetes J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_680477_2 330214.NIDE1318 1.96e-61 192.0 COG0197@1|root,COG0197@2|Bacteria,3J0H7@40117|Nitrospirae 40117|Nitrospirae J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_366909_2 1232410.KI421425_gene1550 2.8e-66 222.0 COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,42Z0Q@68525|delta/epsilon subdivisions,2WU0G@28221|Deltaproteobacteria,43T6R@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1202803_1 195103.CPF_0233 7.83e-39 142.0 COG0382@1|root,COG0382@2|Bacteria,1TRTB@1239|Firmicutes,24AQ0@186801|Clostridia,36E6F@31979|Clostridiaceae 186801|Clostridia H PFAM UbiA prenyltransferase ubiA - - - - - - - - - - - UbiA k59_1202803_2 1329516.JPST01000015_gene740 2.77e-80 248.0 COG1045@1|root,COG1045@2|Bacteria,1TR42@1239|Firmicutes,4HAKS@91061|Bacilli,27AXF@186824|Thermoactinomycetaceae 91061|Bacilli E Serine acetyltransferase, N-terminal cysE GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016053,GO:0016054,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS02865,iYO844.BSU00930 Hexapep,SATase_N k59_1202803_3 1391646.AVSU01000027_gene2386 5.5e-94 289.0 COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,25R1G@186804|Peptostreptococcaceae 186801|Clostridia E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_53690_2 1122604.JONR01000002_gene1652 2.74e-42 144.0 COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,1X6GZ@135614|Xanthomonadales 135614|Xanthomonadales K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_1202811_1 1168034.FH5T_12190 6.6e-44 152.0 COG3293@1|root,COG3293@2|Bacteria,4NM10@976|Bacteroidetes,2G38Y@200643|Bacteroidia 976|Bacteroidetes L Putative transposase of IS4/5 family (DUF4096) - - - - - - - - - - - - DDE_Tnp_1_2,DDE_Tnp_4,DUF4096 k59_1254959_1 1163617.SCD_n01989 1.01e-22 92.8 COG1472@1|root,COG1472@2|Bacteria,1QUPT@1224|Proteobacteria,2VTZ5@28216|Betaproteobacteria 28216|Betaproteobacteria G Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365 k59_1254959_2 648757.Rvan_2027 8.24e-57 186.0 COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,2U3PI@28211|Alphaproteobacteria,3N75R@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria C COG3658 Cytochrome b - - - - - - - - - - - - Ni_hydr_CYTB k59_784950_2 439235.Dalk_0815 3.14e-84 258.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QXM@68525|delta/epsilon subdivisions,2WMZI@28221|Deltaproteobacteria,2MNC9@213118|Desulfobacterales 28221|Deltaproteobacteria O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_784950_3 987059.RBXJA2T_06425 5.82e-17 85.1 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2VJ3S@28216|Betaproteobacteria,1KJXH@119065|unclassified Burkholderiales 28216|Betaproteobacteria IQ reductase fabG GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_366920_1 1219375.CM002139_gene2347 1.17e-18 88.6 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1X3CI@135614|Xanthomonadales 135614|Xanthomonadales G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_366920_2 391625.PPSIR1_25856 1.98e-05 45.4 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2YTZT@29|Myxococcales 28221|Deltaproteobacteria U General secretion pathway protein F gspF - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF k59_1202814_1 1397666.RS24_01364 2.02e-51 182.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_993441_1 1260251.SPISAL_07330 2.89e-33 129.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1WXE2@135613|Chromatiales 135613|Chromatiales EGP PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_628315_2 330214.NIDE2751 3.55e-10 57.8 COG1259@1|root,COG1259@2|Bacteria,3J0RC@40117|Nitrospirae 40117|Nitrospirae S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase k59_889312_1 65071.PYU1_T000821 9.38e-22 105.0 COG0204@1|root,2QY9M@2759|Eukaryota,1MEA9@121069|Pythiales 121069|Pythiales I Acyltransferase. Source PGD - - - - - - - - - - - - Acyltransferase k59_889312_2 105559.Nwat_2285 5.7e-81 261.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales 135613|Chromatiales I PFAM AMP-dependent synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_1306846_1 323850.Shew_3714 8.47e-65 220.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,2Q9N3@267890|Shewanellaceae 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_419094_1 1287116.X734_30195 1.01e-38 135.0 COG0625@1|root,COG0625@2|Bacteria,1Q05U@1224|Proteobacteria,2U5IH@28211|Alphaproteobacteria,43I1H@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_419094_3 448385.sce2973 1.07e-66 221.0 COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria,43A4M@68525|delta/epsilon subdivisions,2WYKE@28221|Deltaproteobacteria,2Z0NN@29|Myxococcales 28221|Deltaproteobacteria E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_53709_1 977880.RALTA_A1959 7.92e-38 143.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VJ1B@28216|Betaproteobacteria,1KFCT@119060|Burkholderiaceae 28216|Betaproteobacteria M TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family - - - - - - - - - - - - OEP k59_1411343_1 314230.DSM3645_17966 6.05e-101 309.0 COG0129@1|root,COG0129@2|Bacteria,2IWXV@203682|Planctomycetes 203682|Planctomycetes H Belongs to the IlvD Edd family ilvD GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_941342_2 1192034.CAP_3564 6.49e-86 265.0 COG2006@1|root,COG2006@2|Bacteria,1NSD4@1224|Proteobacteria,42YV4@68525|delta/epsilon subdivisions,2WTK6@28221|Deltaproteobacteria,2YWVS@29|Myxococcales 28221|Deltaproteobacteria S Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 k59_262419_1 187272.Mlg_0403 2.75e-89 275.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1WWUV@135613|Chromatiales 135613|Chromatiales E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_157514_1 1282876.BAOK01000001_gene3321 2.73e-124 375.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_837040_1 1127673.GLIP_3386 4.47e-05 45.8 2AD08@1|root,312N7@2|Bacteria,1NDC4@1224|Proteobacteria 1224|Proteobacteria S Holin of 3TMs, for gene-transfer release - - - - - - - - - - - - GTA_holin_3TM k59_1411345_1 714943.Mucpa_2051 1.35e-05 55.8 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,4PM8I@976|Bacteroidetes,1IX42@117747|Sphingobacteriia 976|Bacteroidetes QU WD40-like Beta Propeller Repeat - - - - - - - - - - - - Amidohydro_1,PD40 k59_523541_1 1124991.MU9_373 5.04e-78 252.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains atoC GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K02481,ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_941348_1 1121422.AUMW01000009_gene3326 6.63e-28 115.0 COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1UDNN@1239|Firmicutes,24DF4@186801|Clostridia,263HP@186807|Peptococcaceae 186801|Clostridia I DUF35 OB-fold domain, acyl-CoA-associated - - 2.3.3.10 ko:K01641 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130 M00088,M00095 R01978 RC00004,RC00503 ko00000,ko00001,ko00002,ko01000 - - - ACP_syn_III_C,DUF35_N,OB_aCoA_assoc k59_628358_1 1049564.TevJSym_am00710 2.36e-23 101.0 2EFRD@1|root,339HE@2|Bacteria,1NDZX@1224|Proteobacteria,1SBQY@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_628358_3 207954.MED92_04332 0.000934 41.2 COG2138@1|root,COG2138@2|Bacteria,1N00J@1224|Proteobacteria,1SEQ6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S CbiX cbiX - 4.99.1.4 ko:K03794 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R02864 RC01012 ko00000,ko00001,ko00002,ko01000 - - - CbiX k59_419119_1 1279017.AQYJ01000021_gene2879 1.25e-58 201.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,469GD@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_210140_1 1122135.KB893134_gene3972 2.59e-86 271.0 COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,2TQR4@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the BCCT transporter (TC 2.A.15) family - - - ko:K02168 - - - - ko00000,ko02000 2.A.15.1.3,2.A.15.1.4 - - BCCT k59_889348_1 450851.PHZ_c2011 7.63e-90 274.0 COG3367@1|root,COG3367@2|Bacteria,1MVEX@1224|Proteobacteria,2TS0Y@28211|Alphaproteobacteria,2KIDA@204458|Caulobacterales 204458|Caulobacterales S Domain of unknown function (DUF1611_N) Rossmann-like domain - - - - - - - - - - - - DUF1611,DUF1611_N k59_628361_1 1255043.TVNIR_0845 9.65e-14 71.2 2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,1RPSZ@1236|Gammaproteobacteria,1WZX3@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_628361_2 572477.Alvin_0472 2.62e-51 170.0 28IET@1|root,2Z8GT@2|Bacteria,1R4FQ@1224|Proteobacteria,1RS8I@1236|Gammaproteobacteria,1WWZ9@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_210142_1 977880.RALTA_A1733 2.88e-57 193.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,1K1ZE@119060|Burkholderiaceae 28216|Betaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_210142_2 227377.CBU_0869 5.71e-51 172.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1JCEG@118969|Legionellales 118969|Legionellales E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_53751_1 926550.CLDAP_12080 2.91e-53 176.0 COG1484@1|root,COG1484@2|Bacteria,2G7YG@200795|Chloroflexi 200795|Chloroflexi L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_262444_2 925775.XVE_3661 7.6e-25 102.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,1RN38@1236|Gammaproteobacteria,1X3MA@135614|Xanthomonadales 135614|Xanthomonadales I acid) synthase phbC - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1202877_1 1485544.JQKP01000013_gene1782 2.92e-20 84.7 COG3547@1|root,COG3547@2|Bacteria,1P502@1224|Proteobacteria,2W9QQ@28216|Betaproteobacteria,44WNJ@713636|Nitrosomonadales 28216|Betaproteobacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - - k59_1515633_1 1118235.CAJH01000009_gene562 2.47e-10 66.2 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,1X3K4@135614|Xanthomonadales 135614|Xanthomonadales P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_157537_1 1122244.AUGF01000012_gene188 2.35e-10 65.5 COG1075@1|root,COG1075@2|Bacteria,1NYAK@1224|Proteobacteria,1RZ8D@1236|Gammaproteobacteria,3NIGP@468|Moraxellaceae 1236|Gammaproteobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_6,DUF676,PGAP1 k59_889357_1 349163.Acry_1171 2.47e-10 66.2 COG3598@1|root,COG3598@2|Bacteria,1R4EA@1224|Proteobacteria,2U8VM@28211|Alphaproteobacteria,2JXHP@204441|Rhodospirillales 204441|Rhodospirillales L AAA domain - - - - - - - - - - - - AAA_25 k59_1202880_1 742743.HMPREF9453_00336 4.29e-23 95.1 COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,4H4EZ@909932|Negativicutes 909932|Negativicutes L Hydrolase, NUDIX family nudF - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_1202880_2 1370125.AUWT01000031_gene2877 1.17e-08 59.3 COG2141@1|root,COG2141@2|Bacteria,2IBDS@201174|Actinobacteria,2368G@1762|Mycobacteriaceae 201174|Actinobacteria C PFAM luciferase family protein - - - - - - - - - - - - Bac_luciferase k59_628370_1 1229485.AMYV01000021_gene3772 4.9e-41 148.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,1J5CF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the peptidase M20A family. ArgE subfamily - - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_628370_2 1038859.AXAU01000003_gene6202 2.4e-105 309.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,3JU16@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E ATPases associated with a variety of cellular activities - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_680560_1 582744.Msip34_1172 4.99e-40 152.0 COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,2VHI3@28216|Betaproteobacteria,2KKKB@206350|Nitrosomonadales 206350|Nitrosomonadales I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_53762_1 987059.RBXJA2T_08590 2.13e-22 97.1 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VKRZ@28216|Betaproteobacteria,1KITC@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.18 ko:K00822 ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100 - R00907,R04187 RC00008,RC00062,RC00160 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_53762_2 1185766.DL1_07680 2.62e-20 86.7 COG0662@1|root,COG1396@1|root,COG0662@2|Bacteria,COG1396@2|Bacteria,1RCYA@1224|Proteobacteria,2TU8R@28211|Alphaproteobacteria,2XKNF@285107|Thioclava 28211|Alphaproteobacteria K Helix-turn-helix XRE-family like proteins MA20_09770 - - - - - - - - - - - Cupin_2,HTH_3,HTH_31 k59_523578_2 4538.ORGLA05G0201000.1 4.09e-08 57.0 2CMBS@1|root,2QPX1@2759|Eukaryota,37TPJ@33090|Viridiplantae,3GI64@35493|Streptophyta,3KMBW@4447|Liliopsida,3IB9P@38820|Poales 35493|Streptophyta S Cyclic phosphodiesterase-like - - - - - - - - - - - - 2_5_RNA_ligase2,CPDase k59_889365_1 1380394.JADL01000017_gene553 3.13e-67 214.0 COG0583@1|root,COG0583@2|Bacteria,1N4P5@1224|Proteobacteria,2TQYX@28211|Alphaproteobacteria,2JQ80@204441|Rhodospirillales 204441|Rhodospirillales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_785024_1 255470.cbdbA801 9.81e-118 354.0 COG1690@1|root,COG1690@2|Bacteria,2G5NT@200795|Chloroflexi,34D7J@301297|Dehalococcoidia 301297|Dehalococcoidia S tRNA-splicing ligase RtcB rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_1568147_1 1229172.JQFA01000002_gene4509 6.8e-06 50.4 COG0400@1|root,COG0400@2|Bacteria,1G525@1117|Cyanobacteria,1HAT5@1150|Oscillatoriales 1117|Cyanobacteria S phospholipase Carboxylesterase sll1284 - - ko:K06999 - - - - ko00000 - - - Abhydrolase_2 k59_1568147_2 197221.22294632 3.25e-76 241.0 COG0065@1|root,COG0065@2|Bacteria,1G1J0@1117|Cyanobacteria 1117|Cyanobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_1098273_1 472759.Nhal_3787 1.2e-20 88.6 COG0697@1|root,COG0697@2|Bacteria,1MVHN@1224|Proteobacteria,1RM9P@1236|Gammaproteobacteria,1X0WS@135613|Chromatiales 135613|Chromatiales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_1098273_2 1121935.AQXX01000131_gene2844 1.82e-87 258.0 COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,1S1Z9@1236|Gammaproteobacteria,1XJS8@135619|Oceanospirillales 135619|Oceanospirillales E Glyoxalase bleomycin resistance protein dioxygenase - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_471133_1 1379281.AVAG01000029_gene30 1e-19 96.7 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2WJGZ@28221|Deltaproteobacteria,2M9Y5@213115|Desulfovibrionales 28221|Deltaproteobacteria S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_210182_1 1111069.TCCBUS3UF1_2000 4.42e-20 82.8 COG2329@1|root,COG2329@2|Bacteria,1WK6V@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S involved in biosynthesis of extracellular polysaccharides - - - - - - - - - - - - ABM k59_210182_2 1122247.C731_0105 2.78e-96 288.0 COG1011@1|root,COG1011@2|Bacteria,2HHHH@201174|Actinobacteria,2341D@1762|Mycobacteriaceae 201174|Actinobacteria S haloacid dehalogenase dehII - 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase k59_1359480_1 653045.Strvi_1731 4.95e-08 58.2 COG0500@1|root,COG2226@2|Bacteria,2GK7A@201174|Actinobacteria 201174|Actinobacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_31,PadR k59_105529_2 349161.Dred_2547 3.18e-08 56.2 COG1792@1|root,COG1792@2|Bacteria,1TR1V@1239|Firmicutes,249M3@186801|Clostridia,260H4@186807|Peptococcaceae 186801|Clostridia M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_523597_1 1123326.JFBL01000012_gene92 2.09e-47 165.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2YM87@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_523597_2 671143.DAMO_1097 1.63e-16 75.1 COG1826@1|root,COG1826@2|Bacteria,2NQ3N@2323|unclassified Bacteria 2|Bacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatB GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - ko:K03116,ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_785036_1 396588.Tgr7_2333 2.58e-47 158.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1WXDE@135613|Chromatiales 135613|Chromatiales J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_367028_1 1454004.AW11_02120 3.12e-103 309.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria 1224|Proteobacteria C alcohol dehydrogenase - - 1.1.1.1 ko:K00001,ko:K13954 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH k59_471140_1 1378168.N510_00231 2.65e-10 62.0 COG0406@1|root,COG1418@1|root,COG0406@2|Bacteria,COG1418@2|Bacteria,1V4XM@1239|Firmicutes 1239|Firmicutes G PFAM Phosphoglycerate mutase - - 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_315606_1 1332071.L581_3718 2.56e-74 242.0 COG0043@1|root,COG0043@2|Bacteria,1PZMY@1224|Proteobacteria,1S199@1236|Gammaproteobacteria,404PN@613|Serratia 1236|Gammaproteobacteria H Catalyzes the reversible decarboxylation of aromatic carboxylic acids - - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_994221_1 330214.NIDE3308 1.77e-93 279.0 COG3794@1|root,COG3794@2|Bacteria 2|Bacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - CarboxypepD_reg,fn3_3 k59_54824_1 313596.RB2501_00876 1.12e-51 186.0 COG3408@1|root,COG3408@2|Bacteria,4NESP@976|Bacteroidetes,1HY8Y@117743|Flavobacteriia 976|Bacteroidetes G Bacterial alpha-L-rhamnosidase concanavalin-like domain - - 3.2.1.40 ko:K05989 - - - - ko00000,ko01000 - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N k59_1256130_1 1123514.KB905899_gene918 3.49e-36 129.0 COG0664@1|root,COG0664@2|Bacteria,1NPK3@1224|Proteobacteria 1224|Proteobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_419979_1 95619.PM1_0202915 8.58e-65 219.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_681653_1 123214.PERMA_0605 6.87e-120 381.0 COG0308@1|root,COG0750@1|root,COG3016@1|root,COG0308@2|Bacteria,COG0750@2|Bacteria,COG3016@2|Bacteria,2G4YW@200783|Aquificae 200783|Aquificae M Haem-binding uptake, Tiki superfamily, ChaN - - - - - - - - - - - - Cofac_haem_bdg k59_1464838_1 626887.J057_20620 2.93e-91 279.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,464FH@72275|Alteromonadaceae 1236|Gammaproteobacteria J Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_635721_1 1500257.JQNM01000014_gene2912 1.97e-25 102.0 COG0715@1|root,COG0715@2|Bacteria,1PKQN@1224|Proteobacteria,2TSRB@28211|Alphaproteobacteria,4BCDD@82115|Rhizobiaceae 28211|Alphaproteobacteria P 4,5-dihydroxyphthalate decarboxylase - - - - - - - - - - - - NMT1 k59_635721_2 1449345.JHWC01000002_gene1401 1.58e-19 93.6 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,42MWH@68525|delta/epsilon subdivisions,2YMPE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M epimerase dehydratase family - - 5.1.3.2,5.1.3.6 ko:K01784,ko:K08679 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R01385,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_477009_1 1232410.KI421413_gene501 6.49e-46 167.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,43SYQ@69541|Desulfuromonadales 28221|Deltaproteobacteria H Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 k59_321160_1 1089552.KI911559_gene196 1.26e-17 76.3 2E7PS@1|root,3325B@2|Bacteria,1N7R7@1224|Proteobacteria,2UFCM@28211|Alphaproteobacteria,2JUVZ@204441|Rhodospirillales 204441|Rhodospirillales S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - k59_321160_2 357808.RoseRS_2028 1.24e-14 75.9 COG0745@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia 32061|Chloroflexia T histidine kinase A domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_9,Response_reg k59_529186_1 933262.AXAM01000023_gene647 3.56e-11 68.6 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,42MBB@68525|delta/epsilon subdivisions,2WIU1@28221|Deltaproteobacteria,2MHZ5@213118|Desulfobacterales 28221|Deltaproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_529186_2 298655.KI912266_gene6133 5.55e-49 166.0 COG1028@1|root,COG1028@2|Bacteria,2IH8U@201174|Actinobacteria 201174|Actinobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_946714_1 880526.KE386488_gene927 4.5e-72 234.0 COG0043@1|root,COG0043@2|Bacteria,4NHHV@976|Bacteroidetes,2FW7Y@200643|Bacteroidia,22U8R@171550|Rikenellaceae 976|Bacteroidetes H Belongs to the UbiD family - - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_998883_1 1232437.KL661966_gene3144 1.94e-43 149.0 2C477@1|root,32RDF@2|Bacteria,1RKW1@1224|Proteobacteria,42SWN@68525|delta/epsilon subdivisions,2WP88@28221|Deltaproteobacteria,2MNB4@213118|Desulfobacterales 28221|Deltaproteobacteria S DGC domain - - - - - - - - - - - - DGC k59_529189_1 1236541.BALL01000026_gene3034 8.99e-73 244.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,2QAQ3@267890|Shewanellaceae 1236|Gammaproteobacteria H Vitamin B12 dependent methionine synthase activation region metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545 B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_895410_1 314278.NB231_01274 6.78e-57 198.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales 135613|Chromatiales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_792371_1 1232410.KI421414_gene2883 3.08e-86 275.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,43SZI@69541|Desulfuromonadales 28221|Deltaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1104338_1 105559.Nwat_3039 5.57e-37 132.0 2AI7D@1|root,33HQ0@2|Bacteria,1P2AB@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_372648_2 489825.LYNGBM3L_71320 8.31e-136 390.0 COG4976@1|root,COG4976@2|Bacteria 2|Bacteria O Methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25 k59_3630_1 331869.BAL199_05524 1.75e-25 99.0 COG0757@1|root,COG0757@2|Bacteria,1NXE4@1224|Proteobacteria 1224|Proteobacteria E Dehydroquinase class II - - - - - - - - - - - - DHquinase_II k59_3630_2 1037409.BJ6T_07010 1.27e-43 171.0 COG0457@1|root,COG2114@1|root,COG3629@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,BTAD,DZR,Guanylate_cyc,SAM_1,Trans_reg_C k59_1470634_1 1321773.HMPREF9069_01880 1.99e-49 177.0 COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria,4CU9B@84998|Coriobacteriia 84998|Coriobacteriia S ABC transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_738242_1 930946.AEOP01000040_gene741 3.73e-14 77.0 COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,4HAD8@91061|Bacilli,4AX7W@81850|Leuconostocaceae 91061|Bacilli M Cell wall formation murB GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_1470635_1 1121405.dsmv_2439 3.99e-49 161.0 COG1896@1|root,COG1896@2|Bacteria,1R71H@1224|Proteobacteria,42NGN@68525|delta/epsilon subdivisions,2WKMF@28221|Deltaproteobacteria,2MJT4@213118|Desulfobacterales 28221|Deltaproteobacteria S HD domain - - - ko:K07023 - - - - ko00000 - - - HD_3 k59_1210436_1 1500893.JQNB01000001_gene489 1.61e-50 182.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1X2XN@135614|Xanthomonadales 135614|Xanthomonadales M penicillin-binding protein mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_1156165_1 247634.GPB2148_3348 2.57e-67 223.0 COG1629@1|root,COG4771@2|Bacteria,1MUNK@1224|Proteobacteria,1RN9S@1236|Gammaproteobacteria,1J59B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_687834_1 265072.Mfla_0700 7.71e-58 201.0 COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,2VKA1@28216|Betaproteobacteria,2KKJN@206350|Nitrosomonadales 206350|Nitrosomonadales S Dynamin family - - - - - - - - - - - - Dynamin_N k59_425097_1 1144342.PMI40_02345 4.68e-26 102.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VI74@28216|Betaproteobacteria,473HD@75682|Oxalobacteraceae 28216|Betaproteobacteria L Endonuclease/Exonuclease/phosphatase family exoA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_425097_2 87626.PTD2_16962 4.33e-45 152.0 COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria,2Q0XK@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE GO:0000287,GO:0003674,GO:0003824,GO:0004588,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2819,iECIAI39_1322.ECIAI39_4161,iEcSMS35_1347.EcSMS35_3977,iUTI89_1310.UTI89_C4186 Pribosyltran k59_161727_1 314278.NB231_06296 2.54e-58 191.0 COG1763@1|root,COG1763@2|Bacteria,1QYTH@1224|Proteobacteria,1T3U1@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Mo-molybdopterin cofactor biosynthetic process - - - - - - - - - - - - - k59_161727_2 472759.Nhal_2659 0.000665 41.6 COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,1RQ15@1236|Gammaproteobacteria,1X0JQ@135613|Chromatiales 135613|Chromatiales S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - - k59_61224_1 1122604.JONR01000001_gene1715 3.93e-18 90.9 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1RRXM@1236|Gammaproteobacteria,1X9AC@135614|Xanthomonadales 135614|Xanthomonadales K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_529201_1 472759.Nhal_2490 5.35e-302 838.0 COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1WX35@135613|Chromatiales 135613|Chromatiales G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB glgE - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3416 k59_1210449_1 396588.Tgr7_2186 1.52e-193 541.0 COG2221@1|root,COG2221@2|Bacteria,1MVZQ@1224|Proteobacteria,1RQXZ@1236|Gammaproteobacteria,1WWM7@135613|Chromatiales 135613|Chromatiales C reductase, dissimilatory-type beta subunit dsrB - 1.8.99.5 ko:K11181 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_792397_1 1229909.NSED_09015 2.55e-168 490.0 COG1269@1|root,arCOG04138@2157|Archaea,41SRH@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_161731_1 1101195.Meth11DRAFT_1840 1.17e-05 45.4 COG2938@1|root,COG2938@2|Bacteria,1N7P4@1224|Proteobacteria,2VY7W@28216|Betaproteobacteria,2KN8Y@206350|Nitrosomonadales 206350|Nitrosomonadales S Flavinator of succinate dehydrogenase - - - - - - - - - - - - Sdh5 k59_161731_2 1163617.SCD_n01497 4.48e-140 398.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria 28216|Betaproteobacteria C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family sdhB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0022904,GO:0044237,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_17,Fer4_8 k59_161731_3 472759.Nhal_0708 4.29e-94 293.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales 135613|Chromatiales C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_738258_1 1238190.AMQY01000011_gene1968 3.63e-30 113.0 COG3195@1|root,COG3195@2|Bacteria,1RH9S@1224|Proteobacteria,1SAAD@1236|Gammaproteobacteria,1XS3S@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - - - - - - - - - - OHCU_decarbox k59_738258_2 794846.AJQU01000039_gene4996 1.17e-32 124.0 COG0726@1|root,COG3195@1|root,COG0726@2|Bacteria,COG3195@2|Bacteria,1MV3V@1224|Proteobacteria,2TR0I@28211|Alphaproteobacteria,4BAU5@82115|Rhizobiaceae 28211|Alphaproteobacteria G OHCU decarboxylase pucL - 1.7.3.3,3.5.1.41 ko:K00365,ko:K01452 ko00230,ko00232,ko00520,ko01100,ko01120,map00230,map00232,map00520,map01100,map01120 M00546 R02106,R02333,R07981 RC00166,RC00300,RC02107,RC02551 ko00000,ko00001,ko00002,ko01000 - - - OHCU_decarbox,Polysacc_deac_1 k59_687849_1 335541.Swol_2040 7.74e-68 224.0 COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,42JRJ@68298|Syntrophomonadaceae 186801|Clostridia G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PEP-utilizers,PK,PK_C k59_529211_1 765869.BDW_00545 2.22e-33 130.0 COG1012@1|root,COG1012@2|Bacteria,1MV2I@1224|Proteobacteria,42R7M@68525|delta/epsilon subdivisions,2MSMV@213481|Bdellovibrionales,2WMUH@28221|Deltaproteobacteria 213481|Bdellovibrionales C Succinylglutamic semialdehyde dehydrogenase astD - 1.2.1.71 ko:K06447 ko00330,ko01100,map00330,map01100 - R05049 RC00080 ko00000,ko00001,ko01000 - - - Aldedh k59_1470668_1 251229.Chro_0876 1.63e-85 275.0 COG1216@1|root,COG3250@1|root,COG1216@2|Bacteria,COG3250@2|Bacteria,1G2MT@1117|Cyanobacteria,3VNJZ@52604|Pleurocapsales 1117|Cyanobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glyco_hydro_2_C,Glycos_transf_2 k59_998898_1 365528.KB891245_gene6431 3.35e-159 459.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_792418_1 1229909.NSED_02720 1.72e-73 223.0 COG0454@1|root,arCOG00826@2157|Archaea,41T2E@651137|Thaumarchaeota 651137|Thaumarchaeota K Acetyltransferase (GNAT) domain - - 2.3.1.4 ko:K00621 ko00520,map00520 - R02058 RC00004,RC00166 ko00000,ko00001,ko01000 - - - Acetyltransf_1 k59_425123_1 882083.SacmaDRAFT_3288 5.46e-59 203.0 COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,4DZ5Q@85010|Pseudonocardiales 201174|Actinobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_1052070_1 1122134.KB893650_gene843 3.27e-60 206.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1XHCH@135619|Oceanospirillales 135619|Oceanospirillales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_843030_1 502025.Hoch_4078 1.91e-48 170.0 COG1502@1|root,COG1502@2|Bacteria 2|Bacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol - - 3.1.4.4 ko:K01115 ko00564,ko00565,ko01100,ko01110,ko04014,ko04024,ko04071,ko04072,ko04144,ko04666,ko04724,ko04912,ko05231,map00564,map00565,map01100,map01110,map04014,map04024,map04071,map04072,map04144,map04666,map04724,map04912,map05231 - R01310,R02051,R07385 RC00017,RC00425 ko00000,ko00001,ko01000,ko04131 - - - PLDc,PLDc_2 k59_843030_2 1424334.W822_06385 8.74e-08 55.5 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2VNPV@28216|Betaproteobacteria,3T5A4@506|Alcaligenaceae 28216|Betaproteobacteria I Thiolase - - - - - - - - - - - - Thiolase_C k59_635802_1 584708.Apau_0054 6.3e-26 112.0 COG2984@1|root,COG2984@2|Bacteria,3TBSS@508458|Synergistetes 508458|Synergistetes S ABC transporter substrate binding protein - - - - - - - - - - - - ABC_sub_bind k59_1104386_1 1122137.AQXF01000003_gene1995 1.15e-31 127.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_425126_1 251229.Chro_4405 3.82e-59 204.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1G2E2@1117|Cyanobacteria,3VJDV@52604|Pleurocapsales 1117|Cyanobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1262587_1 1132836.RCCGE510_19213 4.88e-80 263.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2TVZI@28211|Alphaproteobacteria,4BAAT@82115|Rhizobiaceae 28211|Alphaproteobacteria C formate dehydrogenase fdsA - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_687878_1 1380350.JIAP01000012_gene423 6.85e-24 108.0 COG1409@1|root,COG2931@1|root,COG3204@1|root,COG1409@2|Bacteria,COG2931@2|Bacteria,COG3204@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,43I5T@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - 3.4.24.40 ko:K01406,ko:K07004 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - An_peroxidase,Cadherin,Calx-beta,Exo_endo_phos,HemolysinCabind,Metallophos,Peptidase_M10_C k59_268516_2 262316.MAP_1657 4.51e-124 363.0 COG0451@1|root,COG0451@2|Bacteria,2I9DG@201174|Actinobacteria,237C3@1762|Mycobacteriaceae 201174|Actinobacteria GM NAD dependent epimerase dehydratase family - - - - - - - - - - - - Epimerase k59_1627145_1 349124.Hhal_0704 1.39e-26 112.0 COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1WWKW@135613|Chromatiales 135613|Chromatiales K ribonuclease BN - - - ko:K07058 - - - - ko00000 - - - Rrf2,Virul_fac_BrkB k59_1365989_1 1380391.JIAS01000012_gene4604 1.32e-10 63.5 COG0451@1|root,COG0451@2|Bacteria,1MVI8@1224|Proteobacteria,2TT7Q@28211|Alphaproteobacteria,2JQKJ@204441|Rhodospirillales 204441|Rhodospirillales GM GDP-mannose 4,6 dehydratase - - 5.1.3.25 ko:K17947 ko00523,ko01130,map00523,map01130 - R10279 RC00289 ko00000,ko00001,ko01000 - - - Epimerase k59_999492_2 1380355.JNIJ01000028_gene736 2.03e-62 204.0 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TUHP@28211|Alphaproteobacteria,3JRVY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family MA20_35605 - - - - - - - - - - - adh_short k59_636774_1 933262.AXAM01000021_gene459 2.55e-31 127.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MJZH@213118|Desulfobacterales 28221|Deltaproteobacteria T CHASE2 - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_843673_1 1249627.D779_0337 2.32e-14 69.7 COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,1SCBI@1236|Gammaproteobacteria,1WZ69@135613|Chromatiales 135613|Chromatiales D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_1313479_1 441620.Mpop_0247 2.24e-14 78.2 COG3206@1|root,COG3206@2|Bacteria,1R5R1@1224|Proteobacteria,2U0R4@28211|Alphaproteobacteria,1JT62@119045|Methylobacteriaceae 28211|Alphaproteobacteria M Chain length determinant protein - - - - - - - - - - - - CbiA,GNVR,Wzz k59_947447_1 502025.Hoch_2090 3.58e-21 97.4 COG3488@1|root,COG3488@2|Bacteria,1MXUW@1224|Proteobacteria,42YAW@68525|delta/epsilon subdivisions,2WTPQ@28221|Deltaproteobacteria,2YU9D@29|Myxococcales 28221|Deltaproteobacteria C Di-haem oxidoreductase, putative peroxidase - - - - - - - - - - - - DHOR k59_896079_1 1535422.ND16A_2292 1.35e-14 74.3 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,2Q6IE@267889|Colwelliaceae 1236|Gammaproteobacteria HJ Belongs to the prokaryotic GSH synthase family gshB GO:0000287,GO:0003674,GO:0003824,GO:0004363,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_3410,iECP_1309.ECP_2941 GSH-S_ATP,GSH-S_N k59_1263534_2 935863.AWZR01000012_gene2528 2.1e-35 122.0 COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,1S8XZ@1236|Gammaproteobacteria,1X78F@135614|Xanthomonadales 135614|Xanthomonadales K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control himD GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_843675_1 365046.Rta_37390 4.36e-25 110.0 COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,4AD1S@80864|Comamonadaceae 28216|Betaproteobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,Pkinase k59_477848_1 903818.KI912268_gene2275 2.1e-22 92.4 COG0087@1|root,COG0087@2|Bacteria,3Y2H7@57723|Acidobacteria 57723|Acidobacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_477848_2 1171373.PACID_25750 1.96e-34 129.0 COG0088@1|root,COG0088@2|Bacteria,2GJYJ@201174|Actinobacteria,4DN59@85009|Propionibacteriales 201174|Actinobacteria J Forms part of the polypeptide exit tunnel rplD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_1105057_1 589865.DaAHT2_0263 2.16e-19 92.4 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42QM3@68525|delta/epsilon subdivisions,2WKI2@28221|Deltaproteobacteria,2MI4S@213118|Desulfobacterales 28221|Deltaproteobacteria M Lysin motif - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_738953_1 864051.BurJ1DRAFT_3967 2.56e-09 64.7 2A2RR@1|root,30R50@2|Bacteria,1RF6F@1224|Proteobacteria,2VYJ0@28216|Betaproteobacteria 28216|Betaproteobacteria S Alginate export - - - ko:K16081 - - - - ko00000,ko02000 1.B.13.1 - - Alginate_exp k59_999518_1 140626.JHWB01000009_gene1679 2.09e-30 117.0 COG1660@1|root,COG1660@2|Bacteria,1TPS4@1239|Firmicutes,248KQ@186801|Clostridia 186801|Clostridia S Displays ATPase and GTPase activities yvcJ - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_1366017_1 697282.Mettu_2589 5.14e-48 159.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1XE36@135618|Methylococcales 135618|Methylococcales O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_1366017_2 1205753.A989_14917 9.37e-38 134.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1X3JC@135614|Xanthomonadales 135614|Xanthomonadales S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_162503_1 1125973.JNLC01000012_gene1063 1.93e-53 178.0 COG0045@1|root,COG0045@2|Bacteria,1R3UY@1224|Proteobacteria,2TVQC@28211|Alphaproteobacteria,3JX19@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Belongs to the succinate malate CoA ligase beta subunit family - - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_162503_2 1411123.JQNH01000001_gene3803 2.45e-143 412.0 COG0074@1|root,COG0074@2|Bacteria,1PY0K@1224|Proteobacteria,2U0IA@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit - - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA,Succ_CoA_lig k59_162503_3 504832.OCAR_6785 8.63e-58 189.0 COG0604@1|root,COG0604@2|Bacteria,1R2DZ@1224|Proteobacteria,2U2KW@28211|Alphaproteobacteria,3JWD1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_216793_1 517418.Ctha_1886 4.8e-115 348.0 COG4147@1|root,COG4147@2|Bacteria,1FDIY@1090|Chlorobi 1090|Chlorobi S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_999536_1 1282876.BAOK01000001_gene2867 5.3e-55 192.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria,4BPKQ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_6107_1 1134474.O59_003432 2.04e-19 84.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1FGTV@10|Cellvibrio 1236|Gammaproteobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_693986_2 742823.HMPREF9465_00438 1.78e-43 159.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,4PQEF@995019|Sutterellaceae 28216|Betaproteobacteria O Heat shock 70 kDa protein dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_800683_1 768671.ThimaDRAFT_3698 2.17e-44 162.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1WWEF@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_1270392_1 768671.ThimaDRAFT_0260 1.42e-28 114.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1WWJA@135613|Chromatiales 135613|Chromatiales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_1270392_2 714313.LSA_11140 2.21e-14 68.9 COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,4HFPW@91061|Bacilli,3F675@33958|Lactobacillaceae 91061|Bacilli J Binds to the 23S rRNA rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_643677_1 1219065.VPR01S_28_00260 7.74e-06 53.5 COG1807@1|root,COG1807@2|Bacteria,1MXH5@1224|Proteobacteria,1RSQE@1236|Gammaproteobacteria,1XVGX@135623|Vibrionales 135623|Vibrionales M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_952784_1 1123368.AUIS01000019_gene1205 1.47e-116 344.0 COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM Succinylglutamate desuccinylase Aspartoacylase - - - - - - - - - - - - AstE_AspA k59_1005131_2 1348114.OM33_17730 2.11e-19 91.3 COG4254@1|root,COG4254@2|Bacteria,1RJR0@1224|Proteobacteria,1S8WR@1236|Gammaproteobacteria,2Q1P5@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - FecR k59_800700_1 1122185.N792_01920 1.1e-45 164.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1X3IV@135614|Xanthomonadales 135614|Xanthomonadales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1478389_1 1123368.AUIS01000023_gene933 2.18e-65 223.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2NDJD@225057|Acidithiobacillales 225057|Acidithiobacillales T Diguanylate cyclase - - - - - - - - - - - - CZB,EAL,GGDEF,PAS,PAS_4 k59_744123_1 483219.LILAB_16180 7.5e-51 174.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,42RUS@68525|delta/epsilon subdivisions,2WNWT@28221|Deltaproteobacteria,2YWXA@29|Myxococcales 28221|Deltaproteobacteria S Peptidogalycan biosysnthesis/recognition - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_848770_1 216596.RL2741 3.99e-25 105.0 COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,1MVV0@1224|Proteobacteria,2TS0V@28211|Alphaproteobacteria,4B8G6@82115|Rhizobiaceae 28211|Alphaproteobacteria CO Cytochrome c biogenesis protein dipZ - - - - - - - - - - - AhpC-TSA,DsbD,Redoxin k59_535203_1 395493.BegalDRAFT_2974 3.27e-39 139.0 COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S364@1236|Gammaproteobacteria,463EC@72273|Thiotrichales 72273|Thiotrichales T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_1579625_1 1027273.GZ77_01440 4.26e-85 265.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMT1@1236|Gammaproteobacteria,1XH3E@135619|Oceanospirillales 135619|Oceanospirillales L DNA polymerase umuC - - ko:K03502 - - - - ko00000,ko03400 - - - DUF4113,IMS,IMS_C,IMS_HHH k59_952811_1 118163.Ple7327_4340 7.38e-83 259.0 COG0463@1|root,COG0463@2|Bacteria,1G4BG@1117|Cyanobacteria,3VJC0@52604|Pleurocapsales 1117|Cyanobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_167726_1 331869.BAL199_30625 3.12e-115 348.0 COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,2U0EG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM Phage - - - - - - - - - - - - Terminase_6C k59_587594_1 187272.Mlg_0168 1.83e-30 110.0 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria,1WZ25@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_587594_2 85643.Tmz1t_0234 2.1e-20 91.3 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,2KUD1@206389|Rhodocyclales 206389|Rhodocyclales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_69115_1 1382306.JNIM01000001_gene3811 1.74e-13 73.2 COG0740@1|root,COG0740@2|Bacteria,2G6BN@200795|Chloroflexi 2|Bacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_744142_1 1089551.KE386572_gene2366 4.13e-10 67.0 COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,2U26R@28211|Alphaproteobacteria,4BS0B@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M AsmA family - - - ko:K07290 - - - - ko00000 9.B.121 - - AsmA,AsmA_2 k59_800769_1 1242864.D187_001116 1.26e-12 67.4 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,42TM2@68525|delta/epsilon subdivisions,2WQ0U@28221|Deltaproteobacteria,2YVHI@29|Myxococcales 28221|Deltaproteobacteria O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_800769_2 187272.Mlg_1900 4.9e-130 388.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1WVW2@135613|Chromatiales 135613|Chromatiales O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1424915_1 998674.ATTE01000001_gene2636 2.72e-114 345.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,1RNCS@1236|Gammaproteobacteria,460BH@72273|Thiotrichales 72273|Thiotrichales S Uncharacterized ACR, YdiU/UPF0061 family - - - - - - - - - - - - UPF0061 k59_694032_1 748247.AZKH_1502 1.34e-54 184.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,2KUWF@206389|Rhodocyclales 28216|Betaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1478458_1 1278073.MYSTI_04082 4.81e-07 50.8 COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria 1224|Proteobacteria S Bile acid sodium symporter - - - ko:K03453 - - - - ko00000 2.A.28 - - SBF k59_1478458_2 296591.Bpro_0981 3.57e-43 155.0 COG3435@1|root,COG3435@2|Bacteria,1MVJP@1224|Proteobacteria,2VM1T@28216|Betaproteobacteria,4ADCW@80864|Comamonadaceae 28216|Betaproteobacteria Q Cupin domain - - 1.13.11.4 ko:K00450 ko00350,ko01100,ko01120,map00350,map01100,map01120 - R02656 RC00764 ko00000,ko00001,ko01000 - - - Cupin_2 k59_1217508_1 1282876.BAOK01000002_gene217 1.85e-52 182.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,4BPT6@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P ammonium transporter, marine subtype - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_953569_3 349521.HCH_01777 1.17e-66 212.0 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1XJNT@135619|Oceanospirillales 135619|Oceanospirillales O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_849555_2 404589.Anae109_3056 1.79e-19 89.0 COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1MXA1@1224|Proteobacteria,42UI3@68525|delta/epsilon subdivisions,2WQ1V@28221|Deltaproteobacteria,2YVFQ@29|Myxococcales 28221|Deltaproteobacteria P Substrate binding domain of ABC-type glycine betaine transport system - - - ko:K05845,ko:K05846 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1,OpuAC k59_431473_1 1229203.KI301992_gene2891 1.85e-06 55.5 COG0438@1|root,COG0438@2|Bacteria,2GMXE@201174|Actinobacteria,3UX6F@52018|unclassified Actinobacteria (class) 201174|Actinobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_1058774_1 880072.Desac_2293 1.86e-54 191.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,2MQ7E@213462|Syntrophobacterales 28221|Deltaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_1005920_1 1038867.AXAY01000022_gene2752 8.71e-26 107.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TU7H@28211|Alphaproteobacteria,3JSWU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria J Amidase MA20_39770 - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_1217520_1 304371.MCP_2273 6.78e-52 179.0 arCOG00787@1|root,arCOG00787@2157|Archaea 2157|Archaea L UvrD REP helicase - - 3.6.4.12 ko:K03657,ko:K07465 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_1371948_1 1150398.JIBJ01000004_gene2789 7.3e-93 302.0 COG3696@1|root,COG3696@2|Bacteria,2I53X@201174|Actinobacteria,1WCG2@1268|Micrococcaceae 201174|Actinobacteria P AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_431479_1 1033734.CAET01000042_gene443 8.94e-11 70.1 COG4584@1|root,COG4584@2|Bacteria,1UW0T@1239|Firmicutes,4HC33@91061|Bacilli,1ZQUA@1386|Bacillus 91061|Bacilli L COG4584 Transposase and inactivated derivatives - - - - - - - - - - - - rve k59_1580375_1 1382306.JNIM01000001_gene1895 4.11e-25 102.0 COG1478@1|root,COG1478@2|Bacteria,2G5TU@200795|Chloroflexi 200795|Chloroflexi S TIGRFAM F420-dependent oxidoreductase - - 6.3.2.31,6.3.2.34 ko:K12234 ko00680,ko01120,map00680,map01120 M00378 R09399,R09400 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000 - - - F420_ligase k59_118237_1 266834.SMc04195 3.63e-99 298.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,4BB9C@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_1371954_1 1038859.AXAU01000001_gene3885 5.94e-40 144.0 COG0524@1|root,COG0524@2|Bacteria,1MVG2@1224|Proteobacteria,2TSDV@28211|Alphaproteobacteria,3JTDI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G pfkB family carbohydrate kinase kdgK - 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PfkB k59_168498_1 358681.BBR47_16050 2.93e-07 57.4 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,26QU5@186822|Paenibacillaceae 91061|Bacilli NT chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_222884_1 1538295.JY96_03090 2.88e-61 207.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KKGI@119065|unclassified Burkholderiales 28216|Betaproteobacteria T nitrogen regulation protein NR(I) ntrC GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_275151_1 550540.Fbal_3038 5.76e-66 216.0 COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,1QTXM@1224|Proteobacteria,1RNQB@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG2169 Adenosine deaminase ada - 3.2.2.21 ko:K01247,ko:K13529 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD k59_6541_1 1131553.JIBI01000004_gene377 2.5e-47 174.0 COG0841@1|root,COG0841@2|Bacteria,1QWAZ@1224|Proteobacteria,2WGXK@28216|Betaproteobacteria,372WP@32003|Nitrosomonadales 28216|Betaproteobacteria V MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1058795_1 13689.BV96_00239 1.47e-51 177.0 COG0346@1|root,COG0346@2|Bacteria,1P5FR@1224|Proteobacteria,2TVCC@28211|Alphaproteobacteria,2K36X@204457|Sphingomonadales 204457|Sphingomonadales E Glyoxalase bleomycin resistance protein dioxygenase - - 1.13.11.25 ko:K16049 ko00984,ko01100,ko01120,ko01220,map00984,map01100,map01120,map01220 - R04597 RC01610 ko00000,ko00001,ko01000 - - - Glyoxalase k59_1058795_2 710685.MycrhN_3209 1.23e-10 61.2 COG1893@1|root,COG1893@2|Bacteria,2GP6K@201174|Actinobacteria,237DD@1762|Mycobacteriaceae 201174|Actinobacteria H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_275153_1 1121949.AQXT01000002_gene796 7.43e-17 82.4 COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,2TSKB@28211|Alphaproteobacteria,43W95@69657|Hyphomonadaceae 28211|Alphaproteobacteria E Belongs to the Orn Lys Arg decarboxylase class-II family ldc - 4.1.1.17 ko:K01581 ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130 M00134 R00670 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1425898_1 188626.HMPREF0321_0591 1.31e-15 81.6 COG0842@1|root,COG1131@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,2GKEU@201174|Actinobacteria,1ZWMH@145357|Dermacoccaceae 201174|Actinobacteria V Forkhead associated domain - - - ko:K01990,ko:K21397 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC_tran,FHA,Yop-YscD_cpl k59_1479530_1 2711.XP_006473256.1 2.44e-19 90.9 COG0621@1|root,KOG4355@2759|Eukaryota,37N3T@33090|Viridiplantae,3GH5N@35493|Streptophyta 35493|Streptophyta J Threonylcarbamoyladenosine tRNA - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0012505,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360 2.8.4.5 ko:K15865 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_644784_1 340.xcc-b100_2882 7.39e-99 304.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,1RN8U@1236|Gammaproteobacteria,1X3DC@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the reversible hydration of fumarate to (S)- malate fumB - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_801857_1 435830.HMPREF0045_01708 1.14e-66 215.0 COG0549@1|root,COG0549@2|Bacteria,2HWQ6@201174|Actinobacteria,4D37Y@85005|Actinomycetales 201174|Actinobacteria E carbamate kinase arcC - 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase k59_431511_1 1173028.ANKO01000193_gene5879 6.47e-91 277.0 COG0451@1|root,COG0451@2|Bacteria,1G3T6@1117|Cyanobacteria,1HA43@1150|Oscillatoriales 1117|Cyanobacteria M Male sterility protein - - - - - - - - - - - - Epimerase k59_118273_1 1049564.TevJSym_aj00060 3.33e-55 194.0 COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,1J98N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U COG0823 Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - PD40 k59_222908_2 1379698.RBG1_1C00001G1318 9.01e-10 61.2 COG0392@1|root,COG0392@2|Bacteria,2NPGZ@2323|unclassified Bacteria 2|Bacteria S Lysylphosphatidylglycerol synthase TM region mprF - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_801878_1 243233.MCA1586 2.41e-75 255.0 COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,1RMW9@1236|Gammaproteobacteria,1XDIT@135618|Methylococcales 135618|Methylococcales G Glycosyl hydrolase 36 superfamily, catalytic domain - - - ko:K13688 - - - - ko00000,ko01000,ko01003 - GH94,GT84 - Glyco_hydro_36,Glyco_transf_36,Glycoamylase k59_1479559_2 247633.GP2143_03923 5.96e-35 130.0 COG1622@1|root,COG2863@1|root,COG1622@2|Bacteria,COG2863@2|Bacteria,1MVYW@1224|Proteobacteria,1RY2R@1236|Gammaproteobacteria,1JC12@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1622 Heme copper-type cytochrome quinol oxidases, subunit 2 - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrom_C k59_849607_1 1121904.ARBP01000004_gene1061 1.9e-31 129.0 COG1361@1|root,COG3209@1|root,COG4733@1|root,COG1361@2|Bacteria,COG3209@2|Bacteria,COG4733@2|Bacteria,4PPHG@976|Bacteroidetes 976|Bacteroidetes M COG3209 Rhs family protein - - - - - - - - - - - - - k59_953631_1 768671.ThimaDRAFT_3867 2.63e-79 253.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1WXRW@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_6552_1 1122604.JONR01000004_gene818 2.03e-106 318.0 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,1RN81@1236|Gammaproteobacteria,1X56F@135614|Xanthomonadales 135614|Xanthomonadales I COG0183 Acetyl-CoA acetyltransferase - - - - - - - - - - - - - k59_431533_1 330214.NIDE3699 9.21e-140 404.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Fer4_12,Fer4_14,Methyltransf_31,Radical_SAM k59_486006_2 631362.Thi970DRAFT_03908 3.62e-21 98.2 COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,1RPY4@1236|Gammaproteobacteria,1WWHS@135613|Chromatiales 135613|Chromatiales M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_902075_2 96561.Dole_2118 3.56e-52 183.0 COG0318@1|root,COG0318@2|Bacteria,1NUXN@1224|Proteobacteria 1224|Proteobacteria IQ AMP-binding enzyme - - - - - - - - - - - - AMP-binding k59_1111043_1 1415778.JQMM01000001_gene580 1.09e-30 125.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1J4FR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein containing LysM domain lysM - - - - - - - - - - - LysM k59_486016_1 1121271.AUCM01000002_gene3892 2.22e-13 74.3 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 k59_644835_1 1121918.ARWE01000001_gene5 1.41e-49 168.0 COG0697@1|root,COG0697@2|Bacteria,1RE85@1224|Proteobacteria,42RRX@68525|delta/epsilon subdivisions,2WNMU@28221|Deltaproteobacteria,43ST0@69541|Desulfuromonadales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_380528_1 1144275.COCOR_03246 2.04e-144 433.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2WJVZ@28221|Deltaproteobacteria,2YU94@29|Myxococcales 28221|Deltaproteobacteria T GTP-binding protein typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_6556_1 159450.NH14_28580 1.58e-40 153.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VN6Z@28216|Betaproteobacteria,1K13I@119060|Burkholderiaceae 28216|Betaproteobacteria G TIGRFAM membrane-bound PQQ-dependent dehydrogenase, glucose quinate shikimate family - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 k59_1372009_1 443255.SCLAV_1869 2.83e-119 363.0 COG0475@1|root,COG0475@2|Bacteria,2GIRC@201174|Actinobacteria 201174|Actinobacteria P Sodium hydrogen exchanger - - - - - - - - - - - - Na_H_Exchanger k59_1633690_1 429009.Adeg_1521 1.97e-79 244.0 COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia,42EWJ@68295|Thermoanaerobacterales 186801|Clostridia J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_1580454_1 990285.RGCCGE502_06019 1.71e-40 144.0 COG0693@1|root,COG0693@2|Bacteria,1N8N6@1224|Proteobacteria,2TT0U@28211|Alphaproteobacteria,4BEVZ@82115|Rhizobiaceae 28211|Alphaproteobacteria S DJ-1/PfpI family - - 4.2.1.103 ko:K18199 ko00930,map00930 - R05771 RC01467 ko00000,ko00001,ko01000,ko01002 - - - DJ-1_PfpI k59_536015_2 330214.NIDE2757 2.1e-40 139.0 COG0052@1|root,COG0052@2|Bacteria,3J0G9@40117|Nitrospirae 40117|Nitrospirae J Belongs to the universal ribosomal protein uS2 family rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_1485562_1 240015.ACP_2303 1.65e-163 475.0 COG1233@1|root,COG1233@2|Bacteria,3Y3I8@57723|Acidobacteria,2JI78@204432|Acidobacteriia 204432|Acidobacteriia C TIGRFAM phytoene desaturase - - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 - R04787,R04798,R04800,R09691,R09692 RC01214,RC02088,RC02605 ko00000,ko00001,ko01000 - - - Amino_oxidase k59_699602_1 1206741.BAFX01000088_gene6070 1.94e-08 60.5 COG1232@1|root,COG1232@2|Bacteria,2GMMA@201174|Actinobacteria,4FU8J@85025|Nocardiaceae 201174|Actinobacteria H protoporphyrinogen oxidase hemG - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_749693_1 1249627.D779_1826 4.4e-77 255.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WXV4@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_8402_1 177439.DP2498 2.35e-63 208.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,42MMB@68525|delta/epsilon subdivisions,2WJEI@28221|Deltaproteobacteria,2MIFI@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2910 ThiC_Rad_SAM k59_1010821_1 880073.Calab_1739 7.06e-32 120.0 COG0524@1|root,COG0524@2|Bacteria,2NP1T@2323|unclassified Bacteria 2|Bacteria G pfkB family carbohydrate kinase adoK GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.15,2.7.1.20 ko:K00852,ko:K00856 ko00030,ko00230,ko01100,map00030,map00230,map01100 - R00185,R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 - - iAF987.Gmet_2683 PfkB k59_907780_1 861299.J421_3811 4.05e-102 320.0 COG1640@1|root,COG1640@2|Bacteria,1ZU23@142182|Gemmatimonadetes 142182|Gemmatimonadetes G 4-alpha-glucanotransferase - - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_809201_1 795359.TOPB45_0614 5.76e-20 90.1 COG1200@1|root,COG1200@2|Bacteria,2GHAE@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_809201_2 1035197.HMPREF9999_02293 4.47e-06 55.1 COG1216@1|root,COG3642@1|root,COG1216@2|Bacteria,COG3642@2|Bacteria,4NIJK@976|Bacteroidetes,2FPB2@200643|Bacteroidia 976|Bacteroidetes T Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - Glycos_transf_2,Kdo k59_77431_1 207954.MED92_10784 1.65e-29 109.0 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,1S8Z7@1236|Gammaproteobacteria,1XKHN@135619|Oceanospirillales 135619|Oceanospirillales S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_1586295_1 596330.HMPREF0628_1626 2.59e-39 140.0 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,22H1B@1570339|Peptoniphilaceae 186801|Clostridia I Belongs to the enoyl-CoA hydratase isomerase family crt - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_1586298_1 1177594.MIC448_2040009 8.75e-58 195.0 COG1249@1|root,COG1249@2|Bacteria,2I3I8@201174|Actinobacteria 201174|Actinobacteria C FAD dependent oxidoreductase - - - - - - - - - - - - FAD_oxidored k59_855460_1 557599.MKAN_03715 3.97e-86 286.0 COG0111@1|root,COG0235@1|root,COG1070@1|root,COG0111@2|Bacteria,COG0235@2|Bacteria,COG1070@2|Bacteria,2GIZV@201174|Actinobacteria,23EW1@1762|Mycobacteriaceae 201174|Actinobacteria EGH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - 1.1.1.399,1.1.1.95,2.7.1.189 ko:K00058,ko:K11216 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko02024,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map02024 M00020 R01513,R11183 RC00002,RC00017,RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,Aldolase_II,SCP2 k59_700471_1 396588.Tgr7_1991 1.4e-19 85.1 COG1011@1|root,COG1011@2|Bacteria,1N0I6@1224|Proteobacteria,1RQ41@1236|Gammaproteobacteria,1WXEC@135613|Chromatiales 135613|Chromatiales S subfamily IA, variant 1 - - 3.1.3.102,3.1.3.104 ko:K20862 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00548,R07280 RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD_2 k59_700471_2 509191.AEDB02000023_gene3630 3.33e-06 49.7 COG3695@1|root,COG3695@2|Bacteria,1UIU9@1239|Firmicutes,25ES2@186801|Clostridia,3WJSV@541000|Ruminococcaceae 186801|Clostridia L 6-O-methylguanine DNA methyltransferase, DNA binding domain - - - ko:K07443 - - - - ko00000 - - - DNA_binding_1 k59_1433094_1 330214.NIDE3226 4.5e-73 236.0 COG1164@1|root,COG1164@2|Bacteria 2|Bacteria E metalloendopeptidase activity pepF - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_1279063_1 1157640.AQWO01000008_gene4096 1.33e-39 143.0 COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria 201174|Actinobacteria E Branched-chain amino acid aminotransferase ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_1064645_1 859657.RPSI07_2717 8.39e-44 156.0 COG0501@1|root,COG0501@2|Bacteria,1NK9F@1224|Proteobacteria,2VQ3C@28216|Betaproteobacteria,1K2G1@119060|Burkholderiaceae 28216|Betaproteobacteria O Peptidase M48 - - - - - - - - - - - - Peptidase_M48 k59_1279070_1 316067.Geob_3703 1.71e-87 272.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,42MG8@68525|delta/epsilon subdivisions,2WJWP@28221|Deltaproteobacteria,43S0X@69541|Desulfuromonadales 28221|Deltaproteobacteria L DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_333504_1 596152.DesU5LDRAFT_3432 1.09e-07 53.1 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WJQQ@28221|Deltaproteobacteria,2M87R@213115|Desulfovibrionales 28221|Deltaproteobacteria C Belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3395 Aldedh k59_1224199_1 572477.Alvin_0357 3.61e-69 220.0 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,1S2U7@1236|Gammaproteobacteria,1WWN0@135613|Chromatiales 135613|Chromatiales L TIGRFAM Phage SPO1 DNA polymerase-related protein - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1116576_1 706587.Desti_0439 3e-28 108.0 COG0664@1|root,COG0664@2|Bacteria,1NAYS@1224|Proteobacteria,42W1E@68525|delta/epsilon subdivisions,2WS96@28221|Deltaproteobacteria,2MS9T@213462|Syntrophobacterales 28221|Deltaproteobacteria T PFAM Cyclic nucleotide-binding domain - - - - - - - - - - - - cNMP_binding k59_652115_1 998674.ATTE01000001_gene2814 4.5e-32 126.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,45ZW4@72273|Thiotrichales 72273|Thiotrichales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_652115_2 1109445.AGSX01000085_gene1461 1.38e-13 67.4 COG0824@1|root,COG0824@2|Bacteria,1RGZN@1224|Proteobacteria,1S64N@1236|Gammaproteobacteria,1Z2H4@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_700491_1 1157490.EL26_22810 5.98e-45 155.0 COG2043@1|root,COG2043@2|Bacteria,1TT5P@1239|Firmicutes,4HFED@91061|Bacilli,2796U@186823|Alicyclobacillaceae 91061|Bacilli S Uncharacterised ArCR, COG2043 - - - - - - - - - - - - DUF169 k59_388039_1 1244869.H261_08493 5.6e-18 78.2 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U70T@28211|Alphaproteobacteria,2JTFN@204441|Rhodospirillales 204441|Rhodospirillales O SelR domain msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_388039_2 1122197.ATWI01000008_gene3213 3.59e-06 48.1 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,464MX@72275|Alteromonadaceae 1236|Gammaproteobacteria J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_809244_1 1195246.AGRI_03139 2.1e-07 60.1 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,1RNJ9@1236|Gammaproteobacteria,464Z5@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG0665 Glycine D-amino acid oxidases (deaminating) - - - ko:K09471 ko00330,ko01100,map00330,map01100 M00136 R07415 RC00062 ko00000,ko00001,ko00002,ko01000 - - - DAO k59_907815_1 1218075.BAYA01000012_gene3696 1.73e-56 181.0 COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2VQDH@28216|Betaproteobacteria,1K3PM@119060|Burkholderiaceae 28216|Betaproteobacteria O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ahp1 - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - Redoxin k59_907815_2 1121861.KB899924_gene3475 7.26e-95 285.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,2JQBK@204441|Rhodospirillales 204441|Rhodospirillales C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_1064670_1 985054.JQEZ01000002_gene3214 4.21e-25 106.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2TT38@28211|Alphaproteobacteria,4NAB3@97050|Ruegeria 28211|Alphaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_1116593_1 330214.NIDE3474 2.3e-127 394.0 COG0841@1|root,COG0841@2|Bacteria,3J0FA@40117|Nitrospirae 40117|Nitrospirae V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296,ko:K18138,ko:K19585 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718,M00767 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.47 - - ACR_tran k59_594061_1 67275.JOAP01000011_gene5146 1.19e-09 64.7 COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria 201174|Actinobacteria KLT serine threonine protein kinase pkn20 - - - - - - - - - - - Pkinase k59_1486867_2 1443111.JASG01000004_gene2234 4.01e-106 315.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TQKK@28211|Alphaproteobacteria,3ZX47@60136|Sulfitobacter 28211|Alphaproteobacteria EP Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1639792_1 399739.Pmen_2051 1.84e-231 646.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1YEF6@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051301,GO:0051704,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_1011749_1 1166948.JPZL01000003_gene437 6.8e-65 215.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1XHIH@135619|Oceanospirillales 135619|Oceanospirillales J Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_1528052_2 1207055.C100_17475 1.16e-26 105.0 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2U99J@28211|Alphaproteobacteria,2K56Y@204457|Sphingomonadales 204457|Sphingomonadales O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE - - ko:K02197 - - - - ko00000 - - - CcmE k59_958931_1 573061.Clocel_1756 1.38e-05 50.4 COG1589@1|root,COG1589@2|Bacteria,1VEMW@1239|Firmicutes,24QKM@186801|Clostridia,36GXB@31979|Clostridiaceae 186801|Clostridia D Essential cell division protein ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_958931_2 1321814.HMPREF9089_01443 2.54e-47 164.0 COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,25UUJ@186806|Eubacteriaceae 186801|Clostridia M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_1377323_1 768671.ThimaDRAFT_2884 6.36e-197 585.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1WXN6@135613|Chromatiales 135613|Chromatiales J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_493313_1 1394178.AWOO02000020_gene7500 1.12e-05 48.1 COG0719@1|root,COG0719@2|Bacteria,2GJNV@201174|Actinobacteria,4EG31@85012|Streptosporangiales 201174|Actinobacteria O Uncharacterized protein family (UPF0051) sufD GO:0008150,GO:0009605,GO:0009607,GO:0040007,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 - ko:K09015 - - - - ko00000 - - - UPF0051 k59_493313_2 483219.LILAB_02825 1.17e-64 209.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,42PJT@68525|delta/epsilon subdivisions,2WKPW@28221|Deltaproteobacteria,2YXCR@29|Myxococcales 28221|Deltaproteobacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_388091_1 1121937.AUHJ01000010_gene1725 2.39e-51 177.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria,465RD@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0859 ADP-heptose LPS heptosyltransferase opsX - - ko:K12982 - - - - ko00000,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_493319_1 290400.Jann_2280 5.2e-18 82.4 COG0261@1|root,COG3743@1|root,COG0261@2|Bacteria,COG3743@2|Bacteria,1MZEW@1224|Proteobacteria,2UBT3@28211|Alphaproteobacteria 28211|Alphaproteobacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - HHH_5,Ribosomal_L21p k59_1377328_1 1469245.JFBG01000019_gene1166 7.15e-98 298.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1WWTN@135613|Chromatiales 1236|Gammaproteobacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine csd - - - - - - - - - - - Aminotran_5 k59_541393_1 519989.ECTPHS_06267 7.89e-07 57.8 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1WYS8@135613|Chromatiales 135613|Chromatiales KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,HAMP,Pkinase,sCache_3_2 k59_281124_1 330214.NIDE3450 2.51e-23 94.7 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c ccoP - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrom_C,Cytochrome_CBB3,FixO k59_281124_2 2055.JNXA01000021_gene3735 1.44e-17 82.4 COG1262@1|root,COG1262@2|Bacteria,2GK9Q@201174|Actinobacteria,4GA9B@85026|Gordoniaceae 201174|Actinobacteria S Sulfatase-modifying factor enzyme 1 - GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005509,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016667,GO:0016670,GO:0018158,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0120147,GO:1901564,GO:1903135 - - - - - - - - - - FGE-sulfatase k59_652181_1 330214.NIDE0482 1.52e-41 145.0 COG4969@1|root,COG4969@2|Bacteria 2|Bacteria NU cell adhesion pilA - - ko:K02650 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - DUF2628,N_methyl,Pilin k59_1639826_1 203908.EGG03184 2.23e-07 55.5 COG2867@1|root,KOG3177@2759|Eukaryota,39KQW@33154|Opisthokonta,3P5BB@4751|Fungi,3V20Q@5204|Basidiomycota,2YFVZ@29000|Pucciniomycotina 4751|Fungi I Polyketide cyclase / dehydrase and lipid transport - - - ko:K18588 - - - - ko00000 - - - Polyketide_cyc k59_1639826_2 2340.JV46_09560 2.77e-98 303.0 COG0475@1|root,COG0475@2|Bacteria,1RB9F@1224|Proteobacteria,1S398@1236|Gammaproteobacteria,1J6EW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P P COG0025 NhaP-type Na H and K H antiporters - - - ko:K11747 - - - - ko00000,ko02000 2.A.37.1.2 - - Na_H_Exchanger k59_809310_1 224325.AF_0988 2.86e-31 124.0 COG2358@1|root,arCOG01802@2157|Archaea 2157|Archaea E TRAP transporter solute receptor, TAXI family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_1224249_1 1121007.AUML01000035_gene1863 5.75e-25 110.0 COG1361@1|root,COG5384@1|root,COG1361@2|Bacteria,COG5384@2|Bacteria,4NMB8@976|Bacteroidetes,1HYNW@117743|Flavobacteriia,2YM6K@290174|Aquimarina 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,DUF11,SdrD_B k59_750625_2 1217720.ALOX01000032_gene283 2.2e-17 83.2 COG5350@1|root,COG5350@2|Bacteria,1RB7D@1224|Proteobacteria,2U59N@28211|Alphaproteobacteria,2JT44@204441|Rhodospirillales 204441|Rhodospirillales S Protein tyrosine phosphatase - - - - - - - - - - - - DSPc k59_1224255_1 1121937.AUHJ01000002_gene3588 1.32e-54 186.0 COG3173@1|root,COG3173@2|Bacteria,1N58U@1224|Proteobacteria,1SNW8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_1166239_1 1235457.C404_13225 2.47e-07 52.8 COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VIAV@28216|Betaproteobacteria,1KGMB@119060|Burkholderiaceae 28216|Betaproteobacteria T Serine/threonine phosphatases, family 2C, catalytic domain pphA - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_1166239_2 768671.ThimaDRAFT_2725 5.62e-24 100.0 COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,1RMDQ@1236|Gammaproteobacteria,1WVZ1@135613|Chromatiales 135613|Chromatiales KLT kinase domain - - - - - - - - - - - - Pkinase k59_1011801_1 215803.DB30_7590 6.07e-22 97.8 COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,42P4E@68525|delta/epsilon subdivisions,2WN09@28221|Deltaproteobacteria,2YUZJ@29|Myxococcales 28221|Deltaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs truD GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_1528080_1 397945.Aave_1174 3.66e-14 72.4 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2VI51@28216|Betaproteobacteria,4AA5K@80864|Comamonadaceae 28216|Betaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluC - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_125476_1 266265.Bxe_C0822 8.61e-76 236.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VNSH@28216|Betaproteobacteria,1KGQD@119060|Burkholderiaceae 28216|Betaproteobacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_700576_1 1333998.M2A_2211 3.2e-35 136.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TTB9@28211|Alphaproteobacteria,4BT9B@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Carboxyl transferase domain - - - - - - - - - - - - Carboxyl_trans k59_228395_1 1121373.KB903632_gene560 0.000623 42.4 COG0367@1|root,COG0367@2|Bacteria,4NFQ3@976|Bacteroidetes,47JSF@768503|Cytophagia 976|Bacteroidetes E Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1639867_1 1411123.JQNH01000001_gene886 4.18e-33 128.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_1639867_2 765911.Thivi_0903 1.77e-143 418.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,1WW5Y@135613|Chromatiales 135613|Chromatiales EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_594139_1 373994.Riv7116_5626 3.62e-81 257.0 COG1696@1|root,COG1696@2|Bacteria,1G2RR@1117|Cyanobacteria,1HN29@1161|Nostocales 1117|Cyanobacteria M MBOAT, membrane-bound O-acyltransferase family - - - - - - - - - - - - MBOAT k59_958979_1 383372.Rcas_3335 5.82e-84 263.0 COG0318@1|root,COG0318@2|Bacteria,2G5Q8@200795|Chloroflexi,376IG@32061|Chloroflexia 32061|Chloroflexia IQ PFAM AMP-dependent synthetase and ligase - - 6.1.3.1,6.2.1.3 ko:K01897,ko:K22319 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1116678_1 930169.B5T_01848 1.08e-30 119.0 COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1XHRE@135619|Oceanospirillales 135619|Oceanospirillales K FR47-like protein - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,DUF3335 k59_1116678_2 686340.Metal_3479 9.9e-96 291.0 COG2866@1|root,COG2866@2|Bacteria,1N6CX@1224|Proteobacteria,1RZAW@1236|Gammaproteobacteria,1XE1U@135618|Methylococcales 135618|Methylococcales E Protein of unknown function (DUF2817) - - - - - - - - - - - - DUF2817 k59_1011830_1 1192034.CAP_1262 6.44e-47 164.0 COG3568@1|root,COG3568@2|Bacteria,1NJUY@1224|Proteobacteria,432E7@68525|delta/epsilon subdivisions,2WXI5@28221|Deltaproteobacteria,2YVNS@29|Myxococcales 28221|Deltaproteobacteria S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_9045_1 519989.ECTPHS_13128 4.39e-27 101.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,1WXYT@135613|Chromatiales 135613|Chromatiales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_9045_2 118797.XP_007457196.1 8.83e-33 122.0 COG0096@1|root,COG0097@1|root,KOG1754@2759|Eukaryota,KOG3254@2759|Eukaryota,39WCS@33154|Opisthokonta 33154|Opisthokonta J rRNA binding MRPL6 GO:0000313,GO:0000315,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0097159,GO:0098798,GO:0140053,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_1116681_1 2002.JOEQ01000032_gene1738 7.16e-32 123.0 COG1236@1|root,COG1236@2|Bacteria,2HEXB@201174|Actinobacteria,4EKR9@85012|Streptosporangiales 201174|Actinobacteria J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL k59_1116681_2 1230343.CANP01000048_gene3678 9.92e-24 101.0 COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,1RPTG@1236|Gammaproteobacteria,1JCII@118969|Legionellales 118969|Legionellales F thymidine phosphorylase activity - - 2.4.2.4 ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C k59_1528100_1 1177181.T9A_00586 6.34e-20 82.8 COG1722@1|root,COG1722@2|Bacteria,1N72V@1224|Proteobacteria,1SC7N@1236|Gammaproteobacteria,1XM23@135619|Oceanospirillales 135619|Oceanospirillales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S k59_1528100_2 876044.IMCC3088_164 3.89e-73 220.0 COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,1S25G@1236|Gammaproteobacteria,1J92R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_173358_1 1348657.M622_05010 8.19e-85 281.0 COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,2WGS4@28216|Betaproteobacteria,2KU8N@206389|Rhodocyclales 206389|Rhodocyclales C Molydopterin dinucleotide binding domain - - 1.17.99.2 ko:K10700,ko:K17050 ko00642,ko01100,ko01120,ko01220,map00642,map01100,map01120,map01220 - R05745 RC00275 ko00000,ko00001,ko01000,ko02000 5.A.3.8,5.A.3.9 - - Molybdopterin,Molydop_binding k59_1381460_1 502025.Hoch_5784 6.66e-66 217.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,42MPG@68525|delta/epsilon subdivisions,2WKW8@28221|Deltaproteobacteria 28221|Deltaproteobacteria HJ RimK-like ATPgrasp N-terminal domain - - - - - - - - - - - - Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK k59_1381460_2 1121918.ARWE01000001_gene3015 1.7e-70 222.0 COG3271@1|root,COG3271@2|Bacteria,1RAD5@1224|Proteobacteria,42QWA@68525|delta/epsilon subdivisions,2WMVM@28221|Deltaproteobacteria,43SVV@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - Peptidase_C39,Peptidase_C39_2 k59_1016310_1 1122599.AUGR01000013_gene746 3.88e-80 243.0 COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,1T06D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_1016310_2 1234364.AMSF01000056_gene1248 7.4e-15 75.9 COG1704@1|root,COG1704@2|Bacteria,1RDUH@1224|Proteobacteria,1S2KR@1236|Gammaproteobacteria,1XDGA@135614|Xanthomonadales 135614|Xanthomonadales S E3 Ubiquitin ligase - - - - - - - - - - - - GIDE k59_1326137_1 631362.Thi970DRAFT_01524 1.27e-83 264.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,1X2HE@135613|Chromatiales 135613|Chromatiales E PFAM Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1229762_1 666685.R2APBS1_3563 1.15e-33 134.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,1X4M7@135614|Xanthomonadales 135614|Xanthomonadales I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_658305_1 1437448.AZRT01000037_gene3057 8.58e-106 311.0 COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,2TRTM@28211|Alphaproteobacteria,1J2M1@118882|Brucellaceae 28211|Alphaproteobacteria Q Fumarylacetoacetate (FAA) hydrolase family ycgM GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0008948,GO:0016787,GO:0016822,GO:0016823,GO:0016829,GO:0016830,GO:0016831,GO:0018773,GO:0031974,GO:0031981,GO:0034545,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0070013 3.7.1.20 ko:K16165 ko00350,ko01100,ko01120,map00350,map01100,map01120 - R01085 RC00326,RC00446 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_83559_1 493475.GARC_1984 9.43e-56 197.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,468GY@72275|Alteromonadaceae 1236|Gammaproteobacteria M esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - POTRA,Patatin,cNMP_binding k59_1285356_1 997346.HMPREF9374_0951 1.15e-71 231.0 COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,4H9ZF@91061|Bacilli,27BGE@186824|Thermoactinomycetaceae 91061|Bacilli C FGGY family of carbohydrate kinases, C-terminal domain glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_1646143_1 1123514.KB905899_gene824 1.96e-95 286.0 COG0725@1|root,COG0725@2|Bacteria,1NACV@1224|Proteobacteria 1224|Proteobacteria P Bacterial extracellular solute-binding protein - - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_391646_2 1168065.DOK_04262 3.26e-12 68.2 2C852@1|root,32YB2@2|Bacteria,1N9HY@1224|Proteobacteria,1SCRT@1236|Gammaproteobacteria,1J6SR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4136) - - - - - - - - - - - - DUF4136 k59_912496_1 998674.ATTE01000001_gene511 1.62e-79 249.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,4601Y@72273|Thiotrichales 72273|Thiotrichales F Belongs to the GARS family purD - 6.3.2.6,6.3.4.13 ko:K01945,ko:K13713 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N,SAICAR_synt k59_499531_1 314278.NB231_05811 1.37e-82 259.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_598545_1 1384056.N787_00565 2.19e-08 55.5 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1X31R@135614|Xanthomonadales 135614|Xanthomonadales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_598545_2 1123400.KB904816_gene1594 2.65e-83 259.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,45ZSU@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_1646157_1 1242864.D187_008934 7.83e-75 251.0 COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,42Z37@68525|delta/epsilon subdivisions,2WUNE@28221|Deltaproteobacteria,2YZFR@29|Myxococcales 28221|Deltaproteobacteria Q Multicopper oxidase - - - - - - - - - - - - - k59_658339_1 1121861.KB899935_gene432 3.91e-70 225.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TR2Z@28211|Alphaproteobacteria,2JQ2N@204441|Rhodospirillales 204441|Rhodospirillales C FAD linked oxidases, C-terminal domain - - 1.1.2.4 ko:K00102 ko00620,map00620 - R00197 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1016344_2 926561.KB900618_gene183 3.51e-21 93.2 COG4929@1|root,COG4929@2|Bacteria,1UPRT@1239|Firmicutes,24NGM@186801|Clostridia 186801|Clostridia S GDYXXLXY protein - - - - - - - - - - - - GDYXXLXY k59_1646170_1 102125.Xen7305DRAFT_00021450 1.09e-175 502.0 COG4992@1|root,COG4992@2|Bacteria,1G4MC@1117|Cyanobacteria,3VMJX@52604|Pleurocapsales 1117|Cyanobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.13 ko:K00819 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R00667 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_391664_1 1237149.C900_03649 1.2e-36 146.0 COG2203@1|root,COG3292@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3292@2|Bacteria,COG4191@2|Bacteria,4NK8Q@976|Bacteroidetes,47M6U@768503|Cytophagia 976|Bacteroidetes KT PFAM Y_Y_Y domain - - - - - - - - - - - - GAF_2,HATPase_c,HTH_18,HisKA,HisKA_2,Reg_prop,Response_reg,SpoIIE,Y_Y_Y k59_1229830_1 1122947.FR7_1422 1.46e-05 53.9 COG3852@1|root,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,4H9HP@909932|Negativicutes 909932|Negativicutes T Histidine kinase - - - - - - - - - - - - - k59_1326183_1 330214.NIDE4194 4.19e-62 196.0 COG2013@1|root,COG2013@2|Bacteria 2|Bacteria S Mitochondrial biogenesis AIM24 WQ51_05710 - - - - - - - - - - - AIM24 k59_1229836_1 2002.JOEQ01000003_gene2497 0.000541 46.2 COG1522@1|root,COG1522@2|Bacteria,2GN6I@201174|Actinobacteria,4EPPE@85012|Streptosporangiales 201174|Actinobacteria K helix_turn_helix ASNC type - - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_1439211_1 1255043.TVNIR_1119 4.02e-135 420.0 COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,1T2GI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.7.5.1,1.8.5.3 ko:K00370,ko:K07306,ko:K17050 ko00910,ko00920,ko01120,ko02020,map00910,map00920,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497,R09501 RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.3,5.A.3.8 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_1439211_2 543526.Htur_1650 2.68e-143 416.0 COG1140@1|root,arCOG01501@2157|Archaea,2XVCI@28890|Euryarchaeota,23S7Y@183963|Halobacteria 183963|Halobacteria C COG1140 Nitrate reductase beta subunit - - 1.7.5.1 ko:K00371 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Fer4_11 k59_499574_1 526222.Desal_2612 5.64e-24 94.4 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,42RVK@68525|delta/epsilon subdivisions,2WNNA@28221|Deltaproteobacteria,2MC4D@213115|Desulfovibrionales 28221|Deltaproteobacteria T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_1069256_1 1121448.DGI_1064 5.09e-21 97.4 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M7UM@213115|Desulfovibrionales 28221|Deltaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1590942_1 314285.KT71_07649 5.07e-72 224.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1J85M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_1229854_1 436308.Nmar_0409 5.95e-108 322.0 COG0579@1|root,arCOG00754@2157|Archaea,41SXA@651137|Thaumarchaeota 651137|Thaumarchaeota S FAD dependent oxidoreductase - - - ko:K15736 - - - - ko00000,ko01000 - - - DAO k59_1169809_1 931626.Awo_c08910 1.03e-12 71.6 COG1082@1|root,COG1082@2|Bacteria,1UZFB@1239|Firmicutes,247UI@186801|Clostridia 186801|Clostridia G sugar phosphate isomerase - - - - - - - - - - - - AP_endonuc_2 k59_1016380_1 580332.Slit_1619 9.56e-153 440.0 COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,2VJGA@28216|Betaproteobacteria 28216|Betaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K21834 - - - - ko00000 - - - CCG,DUF3483,Fer4_8 k59_130779_1 439235.Dalk_4012 1.95e-25 106.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,42MQ4@68525|delta/epsilon subdivisions,2WMDT@28221|Deltaproteobacteria,2MHNR@213118|Desulfobacterales 28221|Deltaproteobacteria S TIGRFAM competence damage-inducible protein CinA cinA GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth k59_130779_2 1123060.JONP01000004_gene611 5.84e-11 65.5 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,2UGK6@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) pgpA - 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - - PgpA k59_598593_1 204669.Acid345_1942 4.08e-117 347.0 COG1899@1|root,COG1899@2|Bacteria,3Y5EW@57723|Acidobacteria,2JJNA@204432|Acidobacteriia 204432|Acidobacteriia O Belongs to the deoxyhypusine synthase family - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS k59_598593_2 1282876.BAOK01000001_gene2355 1.04e-05 49.7 COG1063@1|root,COG1063@2|Bacteria,1MW6Y@1224|Proteobacteria,2TSUK@28211|Alphaproteobacteria 28211|Alphaproteobacteria E alcohol dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_1069275_1 1123392.AQWL01000005_gene3180 1.8e-62 199.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VH7N@28216|Betaproteobacteria,1KRN6@119069|Hydrogenophilales 119069|Hydrogenophilales L Endonuclease/Exonuclease/phosphatase family - - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_1229873_1 247633.GP2143_12134 8.43e-14 67.8 COG2030@1|root,COG2030@2|Bacteria 2|Bacteria I dehydratase - - - - - - - - - - - - MaoC_dehydrat_N k59_1229873_2 247633.GP2143_12129 2.44e-60 189.0 COG2030@1|root,COG2030@2|Bacteria,1RD6F@1224|Proteobacteria 1224|Proteobacteria I Dehydratase - - - - - - - - - - - - MaoC_dehydratas k59_1285468_1 1459636.NTE_00970 1.25e-11 67.0 COG2151@1|root,arCOG03838@1|root,arCOG01845@2157|Archaea,arCOG03838@2157|Archaea,41SHR@651137|Thaumarchaeota 651137|Thaumarchaeota H Coenzyme PQQ synthesis protein D (PqqD) - - - - - - - - - - - - FeS_assembly_P,PqqD k59_1285468_2 935836.JAEL01000061_gene3694 2.52e-24 96.3 COG2077@1|root,COG2077@2|Bacteria,1V474@1239|Firmicutes,4HFMW@91061|Bacilli,1ZARA@1386|Bacillus 91061|Bacilli O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - AhpC-TSA,Redoxin k59_232794_1 227377.CBU_1966 2.5e-08 59.3 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1JC9V@118969|Legionellales 118969|Legionellales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_232794_2 637390.AFOH01000111_gene2830 1.84e-18 84.7 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,2NCR8@225057|Acidithiobacillales 225057|Acidithiobacillales H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_443550_1 105559.Nwat_1094 6.68e-53 181.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1WWB1@135613|Chromatiales 135613|Chromatiales T SMART Nucleotide binding protein, PINc - - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_443550_2 472759.Nhal_0649 1.76e-06 47.8 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,1RQ7F@1236|Gammaproteobacteria,1WY4F@135613|Chromatiales 135613|Chromatiales O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_1493067_1 90814.KL370891_gene1149 4.61e-09 58.2 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,1RQIE@1236|Gammaproteobacteria,460W6@72273|Thiotrichales 72273|Thiotrichales M Belongs to the skp family - - - ko:K06142 - - - - ko00000 - - - OmpH k59_1493067_2 1548151.LS70_07300 0.000446 43.9 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2YMW4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1646261_1 187272.Mlg_1865 1.93e-59 205.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales 135613|Chromatiales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_704998_1 671143.DAMO_1342 4.45e-68 217.0 COG0136@1|root,COG0136@2|Bacteria,2NNX3@2323|unclassified Bacteria 2|Bacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM1523 Semialdhyde_dh,Semialdhyde_dhC k59_912585_1 296591.Bpro_4279 7.69e-70 233.0 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria 28216|Betaproteobacteria E Spermine/spermidine synthase domain - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_83687_2 311424.DhcVS_367 5.15e-10 63.2 COG1235@1|root,COG1235@2|Bacteria,2GBG8@200795|Chloroflexi,34CTS@301297|Dehalococcoidia 301297|Dehalococcoidia S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B_2 k59_83688_1 335283.Neut_1781 5.41e-81 260.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2VHM5@28216|Betaproteobacteria,372EW@32003|Nitrosomonadales 28216|Betaproteobacteria J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_658452_1 1208321.D104_03185 3.34e-06 48.1 COG2209@1|root,COG2209@2|Bacteria,1R33S@1224|Proteobacteria,1RMWV@1236|Gammaproteobacteria,1XIB2@135619|Oceanospirillales 135619|Oceanospirillales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrE - 1.6.5.8 ko:K00350 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_658452_2 998674.ATTE01000001_gene2520 5.92e-61 196.0 COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,4602B@72273|Thiotrichales 72273|Thiotrichales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrD - 1.6.5.8 ko:K00349 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_338115_1 436308.Nmar_1524 2.79e-43 141.0 COG1522@1|root,arCOG01117@2157|Archaea 2157|Archaea K COG1522 Transcriptional regulators - - - - - - - - - - - - AsnC_trans_reg k59_338115_2 1229909.NSED_08835 2.61e-40 138.0 COG1522@1|root,arCOG01117@2157|Archaea 1229909.NSED_08835|- K COG1522 Transcriptional regulators - - - - - - - - - - - - - k59_545819_1 983545.Glaag_3739 1.08e-40 135.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,467SE@72275|Alteromonadaceae 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_1229935_1 1049564.TevJSym_ar00580 9.96e-71 236.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1J52N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_1326248_1 518766.Rmar_2223 3.79e-56 184.0 COG0861@1|root,COG0861@2|Bacteria,4NFFD@976|Bacteroidetes,1FIQZ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P Integral membrane protein TerC family - - - - - - - - - - - - TerC k59_705024_1 1229909.NSED_02990 8.23e-44 144.0 arCOG11305@1|root,arCOG11305@2157|Archaea,41T7G@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1439304_1 765952.PUV_00250 6.87e-65 208.0 28SKE@1|root,2ZEWR@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Methyltransf_24 k59_1493107_1 436308.Nmar_1491 1.33e-35 123.0 arCOG10585@1|root,arCOG10585@2157|Archaea,41SW6@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1493107_2 436308.Nmar_1490 6.01e-68 215.0 COG0180@1|root,arCOG01887@2157|Archaea,41SDK@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family - - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_130860_1 713586.KB900536_gene2959 1.02e-103 312.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1WVYW@135613|Chromatiales 135613|Chromatiales S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_499678_1 1320556.AVBP01000007_gene584 2.71e-17 81.3 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2U182@28211|Alphaproteobacteria,43K4W@69277|Phyllobacteriaceae 28211|Alphaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_499678_2 1453498.LG45_16110 4.88e-08 53.9 COG1858@1|root,COG1858@2|Bacteria,4NJ4X@976|Bacteroidetes,1I05W@117743|Flavobacteriia 976|Bacteroidetes P cytochrome C peroxidase - - - - - - - - - - - - - k59_1532501_1 697282.Mettu_0569 1.07e-145 444.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,1RMSH@1236|Gammaproteobacteria,1XGZE@135618|Methylococcales 135618|Methylococcales G Alpha-amylase domain - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - Alpha-amylase,Malt_amylase_C k59_444795_1 1229909.NSED_02670 5.85e-95 283.0 COG2102@1|root,arCOG00035@2157|Archaea,41SHD@651137|Thaumarchaeota 651137|Thaumarchaeota S Diphthamide synthase - - 6.3.1.14 ko:K06927 - - R03613 RC00358 ko00000,ko01000,ko03012 - - - Diphthami_syn_2 k59_705910_1 314278.NB231_11044 3.52e-154 450.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1WWEC@135613|Chromatiales 135613|Chromatiales S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_1440666_1 323261.Noc_2749 2.52e-42 147.0 COG1051@1|root,COG1051@2|Bacteria,1QUQ0@1224|Proteobacteria,1T20K@1236|Gammaproteobacteria,1X2NY@135613|Chromatiales 135613|Chromatiales F Domain of unknown function (DUF4743) - - - - - - - - - - - - DUF4743,NUDIX k59_1440666_2 1299327.I546_5516 2.27e-21 92.4 COG1011@1|root,COG1011@2|Bacteria,2IBB1@201174|Actinobacteria,23BTU@1762|Mycobacteriaceae 201174|Actinobacteria S Haloacid dehalogenase-like hydrolase - - 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 k59_1122282_1 411464.DESPIG_02119 3.91e-178 514.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria,2M7XR@213115|Desulfovibrionales 28221|Deltaproteobacteria J PFAM Glutamyl glutaminyl-tRNA synthetase, class Ic, catalytic glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C k59_816864_2 1249627.D779_3056 1.14e-84 252.0 COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,1RRM7@1236|Gammaproteobacteria,1X23M@135613|Chromatiales 135613|Chromatiales S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 k59_816864_3 768671.ThimaDRAFT_2003 2.09e-34 119.0 COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,1S8TC@1236|Gammaproteobacteria,1X2H5@135613|Chromatiales 135613|Chromatiales O Sulfurtransferase TusA - - - - - - - - - - - - TusA k59_392518_1 698737.SLGD_02544 1.23e-14 72.0 COG0594@1|root,COG0594@2|Bacteria,1VA78@1239|Firmicutes,4HKG6@91061|Bacilli,4GZ70@90964|Staphylococcaceae 91061|Bacilli J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0031123,GO:0031404,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_392518_2 243233.MCA3033 1.82e-98 301.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1XDZC@135618|Methylococcales 135618|Methylococcales L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_1494374_1 1123392.AQWL01000002_gene1946 0.000679 47.8 2BGVW@1|root,32AVQ@2|Bacteria,1RJYV@1224|Proteobacteria,2W6WT@28216|Betaproteobacteria,1KTCF@119069|Hydrogenophilales 119069|Hydrogenophilales S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_1170655_2 326442.PSHAb0523 4.96e-56 178.0 COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,1S4GX@1236|Gammaproteobacteria,2Q23I@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria U biopolymer transport protein - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_603057_1 157072.XP_008877995.1 1.6e-23 107.0 COG0265@1|root,KOG1421@2759|Eukaryota 2759|Eukaryota O serine-type endopeptidase activity DEG7 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009314,GO:0009416,GO:0009507,GO:0009536,GO:0009628,GO:0009642,GO:0009644,GO:0009892,GO:0010109,GO:0010205,GO:0016787,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0042548,GO:0043155,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043467,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0071704,GO:0140096,GO:1901564,GO:1905156 - - - - - - - - - - PDZ_1,PDZ_2,Trypsin_2 k59_1535803_1 998088.B565_1898 4.33e-106 329.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1Y43H@135624|Aeromonadales 135624|Aeromonadales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_1535803_2 977880.RALTA_A1129 1.15e-46 161.0 COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,2VN5I@28216|Betaproteobacteria,1K1GQ@119060|Burkholderiaceae 28216|Betaproteobacteria C Part of a membrane complex involved in electron transport rnfB - - ko:K03616 - - - - ko00000 - - - FeS,Fer4_21 k59_918305_1 1286106.MPL1_13038 1.34e-21 87.8 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,460FG@72273|Thiotrichales 72273|Thiotrichales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_918305_2 1396141.BATP01000047_gene3950 6.63e-25 97.4 COG0776@1|root,COG0776@2|Bacteria,46XH3@74201|Verrucomicrobia,2IVWK@203494|Verrucomicrobiae 203494|Verrucomicrobiae L Bacterial DNA-binding protein - - - - - - - - - - - - Bac_DNA_binding k59_291397_1 1448139.AI20_18655 4.04e-24 105.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1Y3XR@135624|Aeromonadales 135624|Aeromonadales M transferase waaA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N k59_237498_1 196367.JNFG01000023_gene8116 1.47e-30 122.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,1K063@119060|Burkholderiaceae 28216|Betaproteobacteria T domain protein - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - DUF2222,EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,PAS_9 k59_343591_1 1380394.JADL01000005_gene5610 7.7e-101 311.0 COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2TR1V@28211|Alphaproteobacteria,2JQZQ@204441|Rhodospirillales 204441|Rhodospirillales C COG1905 NADH ubiquinone oxidoreductase 24 kD subunit - - - - - - - - - - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_968213_1 330214.NIDE3064 5.67e-85 265.0 COG0793@1|root,COG0793@2|Bacteria,3J09Y@40117|Nitrospirae 40117|Nitrospirae M tail specific protease - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,Peptidase_S41 k59_89943_1 868131.MSWAN_1185 2.78e-18 79.3 COG0640@1|root,arCOG00731@2157|Archaea,2XYSK@28890|Euryarchaeota 28890|Euryarchaeota K transcriptional - - - - - - - - - - - - HTH_5 k59_136422_1 760192.Halhy_4623 5.76e-28 116.0 COG0477@1|root,COG2814@2|Bacteria,4NEUU@976|Bacteroidetes,1INWC@117747|Sphingobacteriia 976|Bacteroidetes EGP PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,MFS_3 k59_918314_2 909663.KI867150_gene357 1.12e-27 112.0 COG0480@1|root,COG0480@2|Bacteria,1R0V4@1224|Proteobacteria,42M1F@68525|delta/epsilon subdivisions,2WIYM@28221|Deltaproteobacteria,2MR6X@213462|Syntrophobacterales 28221|Deltaproteobacteria J Elongation factor Tu domain 2 fusA-1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1074861_1 1382356.JQMP01000001_gene1166 6.41e-86 268.0 COG0391@1|root,COG0391@2|Bacteria,2G5S2@200795|Chloroflexi,27Y2F@189775|Thermomicrobia 189775|Thermomicrobia S Uncharacterised protein family UPF0052 - - 2.7.8.28 ko:K11212 ko00680,ko01120,map00680,map01120 M00378 R09398 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - UPF0052 k59_1074861_2 1120950.KB892802_gene1408 2.17e-08 58.5 COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria,4DN7M@85009|Propionibacteriales 201174|Actinobacteria H SMART Elongator protein 3 MiaB NifB fbiC - 2.5.1.77 ko:K11779 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_395865_1 324057.Pjdr2_1385 0.000757 44.3 COG3027@1|root,COG3027@2|Bacteria,1VFZR@1239|Firmicutes,4HNRI@91061|Bacilli,26QBQ@186822|Paenibacillaceae 91061|Bacilli D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division zapA - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_918323_1 472759.Nhal_2491 4.61e-71 237.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,1RMSH@1236|Gammaproteobacteria,1WY9K@135613|Chromatiales 135613|Chromatiales G alpha amylase catalytic - - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_1499458_1 1121859.KB890756_gene1547 4.97e-15 74.7 COG0694@1|root,COG0694@2|Bacteria,4NG0Q@976|Bacteroidetes,47PV2@768503|Cytophagia 976|Bacteroidetes O PFAM Scaffold protein Nfu NifU N terminal - - - - - - - - - - - - Nfu_N,NifU k59_1499458_2 1027273.GZ77_13535 4.93e-26 100.0 COG0346@1|root,COG0346@2|Bacteria,1RJR7@1224|Proteobacteria,1S71Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Lactoylglutathione lyase and related lyases - - - - - - - - - - - - Glyoxalase k59_1444382_1 349521.HCH_02714 2.72e-47 168.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,1RMMN@1236|Gammaproteobacteria,1XIFE@135619|Oceanospirillales 135619|Oceanospirillales M Bacterial sugar transferase - - 2.7.8.40 ko:K21303 - - - - ko00000,ko01000,ko01003,ko01005 - - - Bac_transf,CoA_binding_3 k59_1535815_1 1205680.CAKO01000002_gene3128 1.4e-13 71.2 COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2TT2N@28211|Alphaproteobacteria,2JR4G@204441|Rhodospirillales 204441|Rhodospirillales S Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_1535815_2 1158182.KB905024_gene209 1.66e-45 160.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1WX8S@135613|Chromatiales 135613|Chromatiales P PFAM phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_13807_1 998088.B565_2502 4.37e-68 224.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria,1Y3ZH@135624|Aeromonadales 135624|Aeromonadales C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_759638_1 519989.ECTPHS_10154 2.97e-83 258.0 COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,1RRMX@1236|Gammaproteobacteria,1WXC1@135613|Chromatiales 135613|Chromatiales G RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site cbbL - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N k59_395879_1 697282.Mettu_1553 1.87e-116 362.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1XDWG@135618|Methylococcales 135618|Methylococcales J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_822012_1 93220.LV28_10030 4.15e-10 57.4 COG2259@1|root,COG2259@2|Bacteria,1N06A@1224|Proteobacteria,2VU8E@28216|Betaproteobacteria,1K7HP@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM DoxX family protein - - - ko:K15977 - - - - ko00000 - - - DoxX k59_822012_2 279714.FuraDRAFT_0337 9.52e-11 62.0 COG0607@1|root,COG0607@2|Bacteria,1RHQZ@1224|Proteobacteria,2VT6V@28216|Betaproteobacteria,2KS5P@206351|Neisseriales 206351|Neisseriales P Rhodanese-like domain - - - - - - - - - - - - Rhodanese k59_1595346_1 398525.KB900701_gene5932 1.27e-40 153.0 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_343632_1 338969.Rfer_0415 3.66e-23 92.8 COG1495@1|root,COG1495@2|Bacteria,1N2C1@1224|Proteobacteria,2VTN0@28216|Betaproteobacteria,4AICZ@80864|Comamonadaceae 28216|Betaproteobacteria C Disulfide bond formation protein DsbB - - - ko:K03611 - - - - ko00000,ko03110 5.A.2.1 - - DsbB k59_343632_2 1123326.JFBL01000010_gene743 4.89e-29 111.0 COG1651@1|root,COG1651@2|Bacteria,1MVS2@1224|Proteobacteria,42UNJ@68525|delta/epsilon subdivisions,2YRUK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria O Thioredoxin - - - - - - - - - - - - Thioredoxin_4 k59_1291957_1 635013.TherJR_2927 8.72e-51 179.0 COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,260MU@186807|Peptococcaceae 186801|Clostridia C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,POR_N,TPP_enzyme_C k59_918350_2 751994.AGIG01000027_gene1432 2.69e-58 195.0 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,1RMAF@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_180928_3 1137799.GZ78_22835 1.09e-87 281.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1XIU4@135619|Oceanospirillales 135619|Oceanospirillales L Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_664965_2 523791.Kkor_2110 1.03e-39 138.0 COG0670@1|root,COG0670@2|Bacteria,1R7VN@1224|Proteobacteria,1RNKS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the BI1 family - - - ko:K06890 - - - - ko00000 - - - Bax1-I k59_1127059_1 1499967.BAYZ01000155_gene659 4.26e-15 82.4 COG3829@1|root,COG4251@1|root,COG3829@2|Bacteria,COG4251@2|Bacteria,2NR7U@2323|unclassified Bacteria 2|Bacteria T PAS fold - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_1291964_1 582402.Hbal_1466 3.44e-56 198.0 COG1629@1|root,COG4774@1|root,COG1629@2|Bacteria,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2TW2G@28211|Alphaproteobacteria,44151@69657|Hyphomonadaceae 28211|Alphaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1652724_1 420662.Mpe_B0401 1.42e-19 90.1 COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,1KJ17@119065|unclassified Burkholderiales 28216|Betaproteobacteria L DNA topoisomerase III - - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim,Toprim_Crpt,zf-C4_Topoisom k59_395890_1 713587.THITH_10840 1.18e-43 153.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,1X0BZ@135613|Chromatiales 135613|Chromatiales S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_449352_2 2340.JV46_10480 3.46e-52 184.0 COG0437@1|root,COG3302@1|root,COG0437@2|Bacteria,COG3302@2|Bacteria,1MU1B@1224|Proteobacteria,1SYHX@1236|Gammaproteobacteria,1J52W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C DMSO reductase anchor subunit (DmsC) - - - ko:K07307 ko00920,map00920 - R09501 RC02555 ko00000,ko00001,ko02000 5.A.3.3 - - DmsC,Fer4_11,Fer4_4 k59_1595360_1 946483.Cenrod_1684 1.59e-55 195.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2VI7X@28216|Betaproteobacteria,4AA7Z@80864|Comamonadaceae 28216|Betaproteobacteria NU Type II and III secretion system protein gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_550493_1 742159.HMPREF0004_0591 8.88e-43 147.0 COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,2VSZ8@28216|Betaproteobacteria,3T7EA@506|Alcaligenaceae 28216|Betaproteobacteria M Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - - - - - - - - - - Fasciclin k59_1020881_1 743721.Psesu_0325 4.28e-44 152.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1X42P@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the TrpC family trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS k59_1020881_2 243233.MCA2586 3.86e-19 86.7 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1XEAU@135618|Methylococcales 135618|Methylococcales F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_1595365_1 640081.Dsui_3408 1.53e-17 80.1 2BW01@1|root,32RUH@2|Bacteria,1N665@1224|Proteobacteria,2VVCA@28216|Betaproteobacteria,2KWYH@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_1330479_1 1286106.MPL1_12518 1.79e-135 393.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RQBM@1236|Gammaproteobacteria,4607F@72273|Thiotrichales 72273|Thiotrichales E PFAM Aminotransferase class I and II - - - ko:K14261 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_1235695_1 234267.Acid_2052 1.96e-66 223.0 COG2203@1|root,COG3604@1|root,COG2203@2|Bacteria,COG3604@2|Bacteria,3Y9A3@57723|Acidobacteria 57723|Acidobacteria KT Sigma-54 interaction domain - - - ko:K15836 - - - - ko00000,ko03000 - - - GAF_2,HTH_8,Sigma54_activat k59_1235695_2 224911.27354011 1.57e-27 113.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2TW3X@28211|Alphaproteobacteria,3K6S8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria KT Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,PAS,PAS_8,PAS_9,Sigma54_activat k59_237564_1 1408823.AXUS01000014_gene1285 7.28e-42 150.0 COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,248AH@186801|Clostridia,25QMJ@186804|Peptostreptococcaceae 186801|Clostridia E Psort location Cytoplasmic, score - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_1127100_1 713586.KB900536_gene386 2.04e-56 182.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,1WWKQ@135613|Chromatiales 135613|Chromatiales C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein sdhB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_17,Fer4_8 k59_1127100_2 261292.Nit79A3_2533 4.19e-21 92.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,371TZ@32003|Nitrosomonadales 28216|Betaproteobacteria C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1174173_1 1123269.NX02_07350 7.64e-12 64.3 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,2TT3P@28211|Alphaproteobacteria,2K3XJ@204457|Sphingomonadales 204457|Sphingomonadales I Acyltransferase plsC - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_1174173_2 1096930.L284_07955 5.51e-61 196.0 COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,2TS12@28211|Alphaproteobacteria,2K18X@204457|Sphingomonadales 204457|Sphingomonadales E Dual function enzyme catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate and the formation of tyrosine from arogenate tyrC GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43 ko:K00220 ko00400,ko00401,ko01100,ko01110,ko01230,map00400,map00401,map01100,map01110,map01230 M00040 R00732,R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_1500698_2 631362.Thi970DRAFT_04180 1.73e-49 164.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,1WW0C@135613|Chromatiales 135613|Chromatiales F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_969150_2 1042377.AFPJ01000007_gene1859 7.69e-18 80.5 COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,1S90K@1236|Gammaproteobacteria,467KB@72275|Alteromonadaceae 1236|Gammaproteobacteria U Biopolymer transport protein ExbD/TolR exbD1 - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_1445217_2 204536.SULAZ_1484 9.28e-25 101.0 COG2107@1|root,COG2107@2|Bacteria,2G4EE@200783|Aquificae 200783|Aquificae S Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnD - - ko:K11785 ko00130,ko01110,map00130,map01110 - R08589 RC02330 ko00000,ko00001,ko01000 - - - VitK2_biosynth k59_91263_1 1120977.JHUX01000003_gene1511 5.62e-45 156.0 COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,1RQCV@1236|Gammaproteobacteria,3NK39@468|Moraxellaceae 1236|Gammaproteobacteria P ABC transporter modC GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008144,GO:0008150,GO:0008509,GO:0015075,GO:0015098,GO:0015103,GO:0015318,GO:0015399,GO:0015405,GO:0015412,GO:0015689,GO:0015698,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043225,GO:0043492,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0097159,GO:0097367,GO:0098656,GO:0099133,GO:1901265,GO:1901363 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - iECNA114_1301.ECNA114_0696,iECSF_1327.ECSF_0691,iUMNK88_1353.UMNK88_805 ABC_tran,TOBE k59_91263_2 314230.DSM3645_25964 9.42e-25 100.0 COG4149@1|root,COG4149@2|Bacteria,2J01Z@203682|Planctomycetes 203682|Planctomycetes P Binding-protein-dependent transport system inner membrane component - - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_1236827_1 1120951.AUBG01000013_gene2701 3.29e-68 226.0 COG1574@1|root,COG1574@2|Bacteria,4NFMV@976|Bacteroidetes,1HZ70@117743|Flavobacteriia 976|Bacteroidetes S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_603863_1 420324.KI912036_gene2565 2.37e-08 56.6 COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TT5X@28211|Alphaproteobacteria,1JSN4@119045|Methylobacteriaceae 28211|Alphaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_1536580_1 1168034.FH5T_03280 7.76e-54 191.0 COG0457@1|root,COG0823@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins dppX - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 k59_450555_1 479434.Sthe_3459 3.81e-74 235.0 COG1488@1|root,COG1488@2|Bacteria,2GAK8@200795|Chloroflexi,27YGV@189775|Thermomicrobia 189775|Thermomicrobia H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP - - 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - - NAPRTase k59_344773_2 1131266.ARWQ01000001_gene1225 7.17e-73 223.0 COG0118@1|root,arCOG00089@2157|Archaea,41SY2@651137|Thaumarchaeota 651137|Thaumarchaeota E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_760472_2 118168.MC7420_7870 6.39e-06 49.3 COG2820@1|root,COG2820@2|Bacteria,1G05G@1117|Cyanobacteria,1HEPM@1150|Oscillatoriales 1117|Cyanobacteria F Phosphorylase superfamily - - 2.4.2.3 ko:K00757 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01876,R02484,R08229 RC00063 ko00000,ko00001,ko01000 - - - PNP_UDP_1 k59_603868_1 400668.Mmwyl1_4319 7.33e-64 214.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1XI3G@135619|Oceanospirillales 135619|Oceanospirillales G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tktA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_344780_1 1249627.D779_1371 1.59e-67 219.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales 135613|Chromatiales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1653972_2 1265505.ATUG01000002_gene2069 1.8e-15 78.2 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2MI3G@213118|Desulfobacterales 28221|Deltaproteobacteria T response regulator receiver ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_181708_2 472759.Nhal_2379 9.76e-88 290.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_344795_1 1079460.ATTQ01000001_gene5462 1.72e-60 197.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2TSX2@28211|Alphaproteobacteria,4BA0J@82115|Rhizobiaceae 28211|Alphaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_507352_1 1203568.HMPREF1484_01313 3.25e-30 115.0 COG3265@1|root,COG3265@2|Bacteria,2GMW2@201174|Actinobacteria 201174|Actinobacteria G gluconokinase gntK - 2.7.1.12 ko:K00851 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 - R01737 RC00002,RC00017 ko00000,ko00001,ko01000 - - - SKI k59_1653994_1 948071.S4S2F7_9CAUD 6.31e-16 81.3 4QAKM@10239|Viruses,4QUU7@35237|dsDNA viruses no RNA stage,4QPEF@28883|Caudovirales,4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_181711_1 1100720.ALKN01000007_gene2972 1.16e-53 175.0 COG3576@1|root,COG3576@2|Bacteria,1MWG9@1224|Proteobacteria,2VTBU@28216|Betaproteobacteria,4AEGA@80864|Comamonadaceae 28216|Betaproteobacteria S pyridoxamine 5'-phosphate oxidase-related - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_1076166_1 1237149.C900_04938 5.61e-61 197.0 COG0524@1|root,COG0524@2|Bacteria,4NIHI@976|Bacteroidetes,47NUW@768503|Cytophagia 976|Bacteroidetes G Belongs to the carbohydrate kinase PfkB family - - - - - - - - - - - - PfkB k59_428521_1 330214.NIDE3153 6.94e-97 299.0 COG3746@1|root,COG3746@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Porin_O_P k59_691479_1 1511.CLOST_2356 3.08e-112 335.0 COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia,25QJU@186804|Peptostreptococcaceae 186801|Clostridia H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_640323_1 946483.Cenrod_1748 1.6e-46 170.0 COG3459@1|root,COG3459@2|Bacteria,1R1HB@1224|Proteobacteria 1224|Proteobacteria G Glycosyltransferase 36 associated - - - - - - - - - - - - - k59_1002552_1 357804.Ping_1816 5.39e-12 64.7 COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,1RZ45@1236|Gammaproteobacteria,2QIYY@267894|Psychromonadaceae 1236|Gammaproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - ko:K07098 - - - - ko00000 - - - Metallophos,Metallophos_2 k59_481374_1 1229909.NSED_08860 1.92e-82 251.0 COG1756@1|root,arCOG04122@2157|Archaea,41T2T@651137|Thaumarchaeota 651137|Thaumarchaeota J Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA nep1 - 2.1.1.260 ko:K14568 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009 - - - EMG1 k59_324664_1 1286106.MPL1_10367 1.72e-49 165.0 COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,1S4N8@1236|Gammaproteobacteria,460HE@72273|Thiotrichales 72273|Thiotrichales S Peptidase M50 - - - - - - - - - - - - Peptidase_M50 k59_324664_2 519989.ECTPHS_05325 4.09e-212 595.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1WW43@135613|Chromatiales 135613|Chromatiales J TIGRFAM Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_324664_3 1121935.AQXX01000134_gene3607 3.45e-23 96.3 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1XHG7@135619|Oceanospirillales 135619|Oceanospirillales D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_1055496_1 436308.Nmar_0399 2.87e-93 276.0 COG0098@1|root,arCOG04087@2157|Archaea,41SFS@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the universal ribosomal protein uS5 family - - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_1055496_2 1229909.NSED_01935 1.64e-40 137.0 COG1841@1|root,arCOG04086@2157|Archaea,41SMX@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein - - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_691491_2 198214.SF1766 4.84e-12 67.8 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,1RNGM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S nadp-dependent yncB - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N k59_1630203_1 525909.Afer_0246 9.87e-58 198.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2GK2C@201174|Actinobacteria,4CMPV@84992|Acidimicrobiia 84992|Acidimicrobiia H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_1630203_2 1294142.CINTURNW_0600 5.18e-08 54.7 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,24QJE@186801|Clostridia,36MMP@31979|Clostridiaceae 186801|Clostridia K Cold shock protein - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_1630203_3 246969.TAM4_588 0.000302 47.0 COG1011@1|root,arCOG02291@2157|Archaea,2XUJR@28890|Euryarchaeota,2431M@183968|Thermococci 183968|Thermococci S haloacid dehalogenase-like hydrolase - - 3.8.1.2 ko:K01560,ko:K07025 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 k59_1159210_1 876269.ARWA01000001_gene696 3.05e-63 208.0 COG3770@1|root,COG3770@2|Bacteria,1MU9I@1224|Proteobacteria,2TR3K@28211|Alphaproteobacteria,3NAWC@45404|Beijerinckiaceae 28211|Alphaproteobacteria M Penicillin-insensitive murein endopeptidase mepA - - ko:K07261 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M74 k59_640350_2 765913.ThidrDRAFT_4482 1.38e-20 90.1 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RMII@1236|Gammaproteobacteria,1X28K@135613|Chromatiales 135613|Chromatiales C PFAM NADH flavin oxidoreductase NADH oxidase - - - - - - - - - - - - Oxidored_FMN k59_1107788_1 395493.BegalDRAFT_2161 4.33e-52 184.0 COG1305@1|root,COG1305@2|Bacteria,1QQE9@1224|Proteobacteria,1SK9H@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Transglutaminase/protease-like homologues - - - - - - - - - - - - Transglut_core k59_585077_2 502025.Hoch_5472 1.39e-27 112.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2WJ8Q@28221|Deltaproteobacteria,2YYM7@29|Myxococcales 28221|Deltaproteobacteria O Belongs to the ClpX chaperone family - - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small k59_1055514_1 102129.Lepto7375DRAFT_6847 2.66e-37 145.0 COG1523@1|root,COG1523@2|Bacteria,1G0PW@1117|Cyanobacteria 1117|Cyanobacteria G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_640359_1 330214.NIDE2440 1.1e-119 376.0 COG0667@1|root,COG1331@1|root,COG0667@2|Bacteria,COG1331@2|Bacteria,3J0HX@40117|Nitrospirae 40117|Nitrospirae O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_1475146_1 97139.C824_02267 7.44e-08 51.2 COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,24MRS@186801|Clostridia,36JGP@31979|Clostridiaceae 186801|Clostridia J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_1475146_2 290397.Adeh_4181 9.97e-31 110.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria 1224|Proteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_1475146_3 1219626.HMPREF1639_03780 4.14e-23 97.4 COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,247SP@186801|Clostridia,25QXG@186804|Peptostreptococcaceae 186801|Clostridia S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - DUF1967,GTP1_OBG,MMR_HSR1 k59_65810_2 1470591.BW41_03222 1.9e-07 56.2 2DBAU@1|root,2Z84H@2|Bacteria,1QUSM@1224|Proteobacteria,2TW5Z@28211|Alphaproteobacteria,2K089@204457|Sphingomonadales 204457|Sphingomonadales S Putative phage tail protein - - - - - - - - - - - - Phage-tail_3 k59_1002582_1 1444310.JANV01000186_gene500 4.15e-11 60.8 COG0589@1|root,COG0589@2|Bacteria,1V6RY@1239|Firmicutes,4HIZM@91061|Bacilli,1ZHCT@1386|Bacillus 91061|Bacilli T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp k59_1369376_1 156889.Mmc1_2450 8.91e-09 61.6 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS_9,dCache_2 k59_1422455_1 1304888.ATWF01000001_gene1086 3.68e-29 112.0 COG1610@1|root,COG1610@2|Bacteria,2GFQA@200930|Deferribacteres 200930|Deferribacteres S Yqey-like protein - - - ko:K09117 - - - - ko00000 - - - YqeY k59_742375_1 247639.MGP2080_08896 5.17e-91 280.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,1RMP0@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.19,2.6.1.55 ko:K00823,ko:K15372 ko00250,ko00410,ko00430,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00430,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R01684 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1215354_1 1123368.AUIS01000008_gene2193 3.38e-29 114.0 COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,1S6X3@1236|Gammaproteobacteria,2NCTJ@225057|Acidithiobacillales 225057|Acidithiobacillales K Transcriptional regulator, Crp Fnr family - - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_482288_1 56780.SYN_01466 7.96e-20 90.1 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKG2@28221|Deltaproteobacteria,2MRAW@213462|Syntrophobacterales 28221|Deltaproteobacteria T ATPase family associated with various cellular activities (AAA) flbD - - ko:K10943 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_482288_2 243231.GSU0775 4.8e-29 121.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MRH@68525|delta/epsilon subdivisions,2WM8D@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase HAMP - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,sCache_3_3 k59_798294_1 1380347.JNII01000008_gene4422 2.48e-45 164.0 COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4EUAJ@85013|Frankiales 201174|Actinobacteria Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_1215359_1 1220601.L7TQZ6_9CAUD 6.69e-07 50.1 4QBIC@10239|Viruses,4QWHZ@35237|dsDNA viruses no RNA stage,4QTG2@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_847116_1 1049564.TevJSym_bb00050 7.97e-105 326.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_847116_2 340099.Teth39_0216 1.11e-37 140.0 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales 186801|Clostridia C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase gltA - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_1369392_2 1380394.JADL01000008_gene3764 7.14e-31 119.0 28PTM@1|root,2ZCEU@2|Bacteria,1R5DD@1224|Proteobacteria,2TVG7@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Family of unknown function (DUF5309) - - - - - - - - - - - - DUF5309 k59_951023_1 1229909.NSED_08735 1.78e-101 298.0 COG2429@1|root,arCOG04202@2157|Archaea,41SHK@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity gch3 - 3.5.4.29 ko:K08096 ko00740,ko01100,map00740,map01100 - R07306 RC01790 ko00000,ko00001,ko01000 - - - GCH_III k59_742390_1 1232410.KI421425_gene1529 5.2e-14 72.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,42P2Z@68525|delta/epsilon subdivisions,2WNJ6@28221|Deltaproteobacteria,43TGY@69541|Desulfuromonadales 28221|Deltaproteobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_798304_1 1163407.UU7_12491 4.6e-60 194.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1X3ZA@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_798304_2 640081.Dsui_3059 1.09e-183 530.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria,2KU76@206389|Rhodocyclales 206389|Rhodocyclales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_641283_1 1150469.RSPPHO_00672 5.33e-239 678.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria,2JQKB@204441|Rhodospirillales 204441|Rhodospirillales G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_165935_1 58123.JOFJ01000021_gene3947 8.55e-50 162.0 COG2030@1|root,COG2030@2|Bacteria,2IHT0@201174|Actinobacteria,4EK50@85012|Streptosporangiales 201174|Actinobacteria I MaoC like domain - - - - - - - - - - - - MaoC_dehydratas k59_165935_3 876044.IMCC3088_1452 2.04e-20 89.7 COG1545@1|root,COG1545@2|Bacteria,1N7HH@1224|Proteobacteria,1SY5W@1236|Gammaproteobacteria,1JBBQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Rubredoxin-like zinc ribbon domain (DUF35_N) - - - - - - - - - - - - DUF35_N,OB_aCoA_assoc k59_798310_1 247639.MGP2080_12444 4.31e-40 144.0 COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,1RNMV@1236|Gammaproteobacteria,1JAD2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_115126_1 40571.JOEA01000003_gene3799 6.44e-08 56.6 2DBC8@1|root,2Z8C9@2|Bacteria,2I93W@201174|Actinobacteria,4E99F@85010|Pseudonocardiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_692216_1 1349767.GJA_1273 1.59e-42 153.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,47263@75682|Oxalobacteraceae 28216|Betaproteobacteria H Involved in the biosynthesis of porphyrin-containing compound hemN2 - - - - - - - - - - - HemN_C,Radical_SAM k59_585839_1 1408823.AXUS01000018_gene3117 2.34e-14 72.4 COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,25R13@186804|Peptostreptococcaceae 186801|Clostridia S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_1003358_2 1238190.AMQY01000017_gene1439 6.75e-14 74.3 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1XJAY@135619|Oceanospirillales 135619|Oceanospirillales K Belongs to the sigma-70 factor family. ECF subfamily algU - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1215376_1 1047013.AQSP01000144_gene895 5.46e-72 231.0 COG2242@1|root,COG2242@2|Bacteria 2|Bacteria H protein methyltransferase activity - - - - - - - - - - - - Methyltransf_21 k59_1056285_2 644968.DFW101_3346 5.19e-17 75.5 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,42V30@68525|delta/epsilon subdivisions,2WRH7@28221|Deltaproteobacteria,2MCHE@213115|Desulfovibrionales 28221|Deltaproteobacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_899596_1 243233.MCA2489 8.22e-87 270.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1XETA@135618|Methylococcales 135618|Methylococcales F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,Pribosyltran k59_899596_2 857087.Metme_0610 2.69e-06 48.5 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria,1XFN7@135618|Methylococcales 135618|Methylococcales S PFAM Colicin V production protein - - - ko:K03558 - - - - ko00000 - - - Colicin_V k59_641299_1 436308.Nmar_0284 1.31e-282 779.0 COG0651@1|root,arCOG01537@2157|Archaea,41SAV@651137|Thaumarchaeota 651137|Thaumarchaeota C plastoquinone (complex I) - - 1.6.5.3 ko:K00342,ko:K12137,ko:K12141 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1056289_2 444861.E3SPU1_9CAUD 2.7e-18 77.8 4QDJR@10239|Viruses,4QXUQ@35237|dsDNA viruses no RNA stage,4QU9R@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1056289_3 444876.E3SQM6_9CAUD 2.48e-10 56.2 4QAWS@10239|Viruses,4QWXG@35237|dsDNA viruses no RNA stage,4QPNR@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1522415_1 1441629.PCH70_51560 4.02e-27 115.0 COG2199@1|root,COG3706@2|Bacteria,1MZRQ@1224|Proteobacteria,1RWZX@1236|Gammaproteobacteria,1ZA77@136849|Pseudomonas syringae group 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,dCache_1 k59_951050_1 1408452.JAGZ01000001_gene3750 5.81e-66 207.0 COG2030@1|root,COG2030@2|Bacteria,2GN7T@201174|Actinobacteria,235VM@1762|Mycobacteriaceae 201174|Actinobacteria I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydrat_N k59_1215389_2 717785.HYPMC_3627 4.34e-08 58.9 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2TR8J@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the GcvT family ygfZ - - ko:K06980,ko:K22073 - - - - ko00000,ko01000,ko03016,ko03029 - - - GCV_T,GCV_T_C k59_955670_1 469371.Tbis_3306 2.01e-20 93.6 COG1912@1|root,COG1912@2|Bacteria,2IASJ@201174|Actinobacteria,4E3VM@85010|Pseudonocardiales 201174|Actinobacteria S S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans k59_488647_1 1282876.BAOK01000001_gene2741 7.12e-18 79.3 COG4633@1|root,COG4633@2|Bacteria,1N1UQ@1224|Proteobacteria,2UEDS@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Cupredoxin-like domain - - - - - - - - - - - - Cupredoxin_1 k59_1008075_1 396588.Tgr7_0841 2.31e-115 344.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1WWW0@135613|Chromatiales 135613|Chromatiales O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_1113133_1 436308.Nmar_0007 3.93e-57 191.0 COG0652@1|root,arCOG04767@2157|Archaea,41T0W@651137|Thaumarchaeota 651137|Thaumarchaeota O Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_904243_1 1298598.JCM21714_4192 1.46e-13 75.5 COG0561@1|root,COG0561@2|Bacteria,1V5FB@1239|Firmicutes,4HGY8@91061|Bacilli 91061|Bacilli F hydrolases of the HAD superfamily - - - - - - - - - - - - Hydrolase_3 k59_1320068_1 396588.Tgr7_3279 2.04e-100 300.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1WW5T@135613|Chromatiales 135613|Chromatiales F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD - 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_1582605_1 865861.AZSU01000004_gene979 1.06e-44 159.0 COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,247Y5@186801|Clostridia,36DP3@31979|Clostridiaceae 186801|Clostridia H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS thiI - 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07461 - ko00000,ko00001,ko01000,ko03016 - - - THUMP,ThiI k59_648578_2 469383.Cwoe_3478 1.37e-26 113.0 COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria 201174|Actinobacteria Q Belongs to the long-chain O-acyltransferase family - - - - - - - - - - - - DUF1298,WES_acyltransf k59_435045_1 1380394.JADL01000014_gene194 5.77e-60 195.0 COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2TTDT@28211|Alphaproteobacteria,2JVI9@204441|Rhodospirillales 204441|Rhodospirillales G D-galactarate dehydratase / Altronate hydrolase, C terminus - - - - - - - - - - - - GD_AH_C k59_435045_2 1131814.JAFO01000001_gene1568 1.53e-16 78.2 COG2128@1|root,COG2128@2|Bacteria,1N0RE@1224|Proteobacteria,2TQZK@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_489789_1 1182590.BN5_01411 2.98e-90 289.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1YEEV@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008986,GO:0009058,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - iEcE24377_1341.EcE24377A_1919,iYL1228.KPN_02160 PEP-utilizers,PEP-utilizers_C,PPDK_N k59_852731_1 436308.Nmar_0543 2.95e-23 97.1 COG0422@1|root,arCOG02741@2157|Archaea,41S5Z@651137|Thaumarchaeota 651137|Thaumarchaeota H Thiamine biosynthesis protein ThiC - - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC_Rad_SAM k59_852731_2 436308.Nmar_0544 1.77e-60 189.0 COG1184@1|root,arCOG01127@2157|Archaea,41T2Z@651137|Thaumarchaeota 651137|Thaumarchaeota L NUDIX domain - - - - - - - - - - - - NUDIX k59_1164290_1 153721.MYP_3027 2.21e-74 253.0 COG1201@1|root,COG1201@2|Bacteria,4NGQ0@976|Bacteroidetes,47NAU@768503|Cytophagia 976|Bacteroidetes L DEAD DEAH box helicase lhr - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_852736_1 56780.SYN_01387 4.7e-17 85.5 COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria 1224|Proteobacteria L PFAM Integrase - - - - - - - - - - - - rve k59_1483365_1 1073999.BN137_1293 3.78e-78 253.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360 - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_538855_1 1121861.KB899913_gene2258 1.36e-104 311.0 COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,2JR12@204441|Rhodospirillales 204441|Rhodospirillales E Oligopeptide/dipeptide transporter, C-terminal region - - - - - - - - - - - - ABC_tran,oligo_HPY k59_278479_1 1415779.JOMH01000001_gene2449 1.86e-30 125.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,1X5V0@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_1062106_1 436308.Nmar_0011 1.45e-151 445.0 COG0464@1|root,arCOG01308@2157|Archaea,41SX8@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48), domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_1429664_1 479435.Kfla_2117 5.93e-53 186.0 COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4DSZJ@85009|Propionibacteriales 201174|Actinobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_435072_1 1207063.P24_11265 7.83e-92 285.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQQH@28211|Alphaproteobacteria,2JPYV@204441|Rhodospirillales 204441|Rhodospirillales E Bacterial extracellular solute-binding proteins, family 5 Middle - - - - - - - - - - - - SBP_bac_5 k59_805667_1 1120950.KB892756_gene6634 1.14e-20 95.5 COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4DPCW@85009|Propionibacteriales 201174|Actinobacteria E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_805667_2 314271.RB2654_00080 6.23e-17 85.1 COG0673@1|root,COG0673@2|Bacteria,1N0VK@1224|Proteobacteria,2U24K@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_591323_1 1341646.CBMO010000127_gene3325 4.62e-17 84.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,233DK@1762|Mycobacteriaceae 201174|Actinobacteria C cytochrome p450 cyp123A3 GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616,GO:1902652 - - - - - - - - - - p450 k59_697793_1 1123073.KB899245_gene60 7.52e-87 267.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1X3NP@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA kbl - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_747899_1 1382306.JNIM01000001_gene569 8.51e-27 115.0 COG0624@1|root,COG4992@1|root,COG0624@2|Bacteria,COG4992@2|Bacteria,2G5SG@200795|Chloroflexi 200795|Chloroflexi E Catalyzes the transfer of the amino group of L-glutamate to LysW -aminoadipate 6-semialdehyde, generating LysW -gamma-L- lysine lysJ - - ko:K05830 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00031,M00763 R09778,R10932 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3,Peptidase_M20 k59_905172_2 697282.Mettu_2979 1.93e-33 129.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1XDNN@135618|Methylococcales 135618|Methylococcales O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_384396_1 589865.DaAHT2_0296 2.67e-58 191.0 COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,42MRB@68525|delta/epsilon subdivisions,2WIZD@28221|Deltaproteobacteria,2MIFB@213118|Desulfobacterales 28221|Deltaproteobacteria C TIGRFAM sulfite reductase, dissimilatory-type alpha subunit dsrA - 1.8.99.5 ko:K11180 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_435083_1 1387312.BAUS01000007_gene2284 6.98e-69 227.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2VH2H@28216|Betaproteobacteria,2KMCV@206350|Nitrosomonadales 206350|Nitrosomonadales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_747900_1 1280685.AUKC01000013_gene206 2.02e-07 56.2 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia,4BWDJ@830|Butyrivibrio 186801|Clostridia NT Signal transducing histidine kinase, homodimeric domain cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,P2 k59_747900_2 290397.Adeh_2734 2.27e-15 75.1 COG0835@1|root,COG0835@2|Bacteria,1PEGB@1224|Proteobacteria,43466@68525|delta/epsilon subdivisions,2X1U3@28221|Deltaproteobacteria,2YYW0@29|Myxococcales 28221|Deltaproteobacteria NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_852769_1 292459.STH2826 4.89e-65 222.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia 186801|Clostridia L DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_171394_4 1380394.JADL01000011_gene3865 9.41e-45 151.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,2JPS1@204441|Rhodospirillales 204441|Rhodospirillales O Belongs to the GST superfamily - - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_N,GST_N_3 k59_1374886_1 335541.Swol_1884 4.29e-40 149.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,42JJQ@68298|Syntrophomonadaceae 186801|Clostridia H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - ACPS,Carb_kinase,YjeF_N k59_1114070_1 572477.Alvin_1986 7.52e-159 455.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1WWHV@135613|Chromatiales 135613|Chromatiales E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_1114070_2 400682.PAC_15705943 1.32e-13 70.5 COG0187@1|root,KOG0355@2759|Eukaryota,39WG1@33154|Opisthokonta,3BNSE@33208|Metazoa 33208|Metazoa B DNA gyrase C-terminal domain, beta-propeller - - - - - - - - - - - - DNA_gyraseA_C,DNA_topoisoIV k59_1221165_1 517418.Ctha_0993 4.41e-54 181.0 COG0697@1|root,COG0697@2|Bacteria 2|Bacteria EG spore germination cnrT - - - - - - - - - - - EamA k59_171407_1 323848.Nmul_A2360 2.14e-37 143.0 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2VIVD@28216|Betaproteobacteria,3743J@32003|Nitrosomonadales 28216|Betaproteobacteria U Pilus formation protein N terminal region cpaC1 - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - BON,Secretin,T2SS-T3SS_pil_N k59_591373_1 856793.MICA_2098 3.52e-24 102.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria,4BPE7@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_489891_1 1121921.KB898709_gene183 5.46e-84 268.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,2PMHD@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria V ABC transporter transmembrane region msbA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - iJN746.PP_4935,iPC815.YPO1395,iUMN146_1321.UM146_12980 ABC_membrane,ABC_tran k59_747947_1 1304883.KI912532_gene1711 1.29e-15 83.2 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,2KUGH@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971,DUF748 k59_1275577_2 713586.KB900536_gene887 6.9e-08 60.1 COG1404@1|root,COG2340@1|root,COG1404@2|Bacteria,COG2340@2|Bacteria,1RC5K@1224|Proteobacteria,1S3I9@1236|Gammaproteobacteria,1WXY7@135613|Chromatiales 135613|Chromatiales O Subtilase family - - - - - - - - - - - - Peptidase_S8 k59_1483449_2 305900.GV64_23045 1.98e-79 237.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,1S201@1236|Gammaproteobacteria,1XJ5K@135619|Oceanospirillales 135619|Oceanospirillales J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_1483449_3 1123360.thalar_02603 4.45e-15 69.7 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2UF59@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_122234_1 287.DR97_4935 8.48e-57 204.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1YD4M@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1429750_1 1282356.H045_16885 5.6e-55 182.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1YNER@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria F Carbamoyl-phosphate synthetase glutamine chain carA GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,ic_1306.c0040 CPSase_sm_chain,GATase k59_489910_2 1122915.AUGY01000084_gene6195 1.07e-37 131.0 COG0346@1|root,COG0346@2|Bacteria,1VCGT@1239|Firmicutes,4HKDV@91061|Bacilli,26ZEW@186822|Paenibacillaceae 91061|Bacilli E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_805760_1 1049564.TevJSym_ah00790 2.82e-58 187.0 COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,1RQAB@1236|Gammaproteobacteria,1JAT3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D probably involved in intracellular septation ispZ GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K06190 - - - - ko00000 - - - IspA k59_1583671_1 472759.Nhal_2453 1.31e-67 214.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1WXRN@135613|Chromatiales 135613|Chromatiales J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_1583671_2 1134474.O59_002611 1.62e-20 88.6 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1FH1R@10|Cellvibrio 1236|Gammaproteobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_1320764_1 1232410.KI421415_gene3029 3.11e-63 207.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42NDT@68525|delta/epsilon subdivisions,2WIWZ@28221|Deltaproteobacteria,43U9Z@69541|Desulfuromonadales 28221|Deltaproteobacteria E PFAM aspartate glutamate uridylate kinase lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_1320764_2 485916.Dtox_3739 9.33e-37 131.0 COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,2621R@186807|Peptococcaceae 186801|Clostridia S PFAM Uncharacterised P-loop hydrolase UPF0079 ydiB - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k59_435158_1 1122604.JONR01000031_gene1276 5.79e-21 91.7 COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,1RNQP@1236|Gammaproteobacteria,1X319@135614|Xanthomonadales 135614|Xanthomonadales P L-lysine 6-monooxygenase (NADPH-requiring) - - - ko:K07222 - - - - ko00000 - - - Pyr_redox_3 k59_435158_2 1283300.ATXB01000001_gene112 2.94e-07 53.5 2BC0N@1|root,309Q5@2|Bacteria,1QT0H@1224|Proteobacteria,1SSPP@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1164362_1 391587.KAOT1_19772 4.32e-25 102.0 COG0491@1|root,COG0491@2|Bacteria,4NHG1@976|Bacteroidetes,1HYC1@117743|Flavobacteriia 976|Bacteroidetes S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1164362_2 1279019.ARQK01000018_gene2548 3.04e-73 223.0 COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,1S3PT@1236|Gammaproteobacteria,1WX50@135613|Chromatiales 135613|Chromatiales O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB k59_697878_1 228410.NE2177 2.55e-20 94.0 2DBT3@1|root,2ZAV9@2|Bacteria,1R6IW@1224|Proteobacteria,2W261@28216|Betaproteobacteria,373V5@32003|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_171431_1 1496688.ER33_14485 3.45e-19 87.0 COG0720@1|root,COG0720@2|Bacteria,1G0ND@1117|Cyanobacteria,22RR3@167375|Cyanobium 1117|Cyanobacteria H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_171431_2 401053.AciPR4_1066 6.63e-36 127.0 COG0302@1|root,COG0302@2|Bacteria,3Y2SP@57723|Acidobacteria,2JIR1@204432|Acidobacteriia 204432|Acidobacteriia H TIGRFAM GTP cyclohydrolase I folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_225898_1 29581.BW37_01689 2.4e-18 78.2 COG0236@1|root,COG0236@2|Bacteria,1N6RU@1224|Proteobacteria,2VWKA@28216|Betaproteobacteria,474SX@75682|Oxalobacteraceae 28216|Betaproteobacteria IQ acyl carrier protein - - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_225898_2 319224.Sputcn32_0447 4.09e-42 153.0 COG0204@1|root,COG0204@2|Bacteria,1RDN7@1224|Proteobacteria,1S4Z5@1236|Gammaproteobacteria,2Q8P3@267890|Shewanellaceae 1236|Gammaproteobacteria I PFAM phospholipid glycerol acyltransferase - - - - - - - - - - - - Acyltransferase k59_1114119_1 2340.JV46_23610 1.51e-05 45.4 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,1J6FM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_1114119_2 1286106.MPL1_02188 5.46e-56 193.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,46034@72273|Thiotrichales 72273|Thiotrichales U TIGRFAM type IV pilus secretin (or competence protein) PilQ pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_648721_1 626887.J057_03440 7.67e-15 68.6 COG3492@1|root,COG3492@2|Bacteria,1MZ3I@1224|Proteobacteria,1S8SI@1236|Gammaproteobacteria,467TP@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria IV02_17390 - - ko:K09948 - - - - ko00000 - - - DUF1244 k59_648721_2 265072.Mfla_2311 4.67e-41 147.0 COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,2VJR6@28216|Betaproteobacteria,2KMDP@206350|Nitrosomonadales 206350|Nitrosomonadales C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1483488_1 1366050.N234_01100 1.88e-88 269.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VGZM@28216|Betaproteobacteria,1K28G@119060|Burkholderiaceae 28216|Betaproteobacteria P Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran k59_1275630_1 1110697.NCAST_32_00490 2.15e-23 102.0 COG3000@1|root,COG3000@2|Bacteria,2HHKY@201174|Actinobacteria,4FZ1A@85025|Nocardiaceae 201174|Actinobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_956618_1 1237149.C900_05256 8.55e-55 194.0 COG1131@1|root,COG1131@2|Bacteria,4NHPD@976|Bacteroidetes,47KQD@768503|Cytophagia 976|Bacteroidetes V ABC-2 type transporter - - - - - - - - - - - - ABC2_membrane,ABC_tran,TerB k59_1637305_1 1122135.KB893134_gene3201 3.53e-30 117.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2TUFG@28211|Alphaproteobacteria 28211|Alphaproteobacteria M glycosyl transferase group 1 redB - - - - - - - - - - - Glycos_transf_1 k59_1637305_2 1380391.JIAS01000018_gene838 1.9e-177 508.0 COG4671@1|root,COG4671@2|Bacteria,1N1PQ@1224|Proteobacteria,2TSTV@28211|Alphaproteobacteria,2JRG0@204441|Rhodospirillales 204441|Rhodospirillales S Glycosyltransferase family 28 C-terminal domain - - - - - - - - - - - - Glyco_tran_28_C k59_489960_1 400668.Mmwyl1_0411 3.3e-41 139.0 COG1764@1|root,COG1764@2|Bacteria,1RI5C@1224|Proteobacteria,1S4EM@1236|Gammaproteobacteria,1XQYY@135619|Oceanospirillales 135619|Oceanospirillales O OsmC-like protein - - - - - - - - - - - - OsmC k59_489960_2 472759.Nhal_0806 6.2e-53 168.0 COG0073@1|root,COG0073@2|Bacteria,1RGU7@1224|Proteobacteria,1S6NH@1236|Gammaproteobacteria,1X12N@135613|Chromatiales 135613|Chromatiales J Putative tRNA binding domain - - - ko:K06878 - - - - ko00000 - - - tRNA_bind k59_852856_1 1002340.AFCF01000031_gene4101 1.96e-22 99.4 COG2114@1|root,COG2114@2|Bacteria,1ND4Q@1224|Proteobacteria,2U51W@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Protein of unknown function (DUF2652) - - - - - - - - - - - - DUF2652,Polyketide_cyc2 k59_1494721_1 459349.CLOAM0865 5.25e-21 89.0 29EG8@1|root,334DW@2|Bacteria,2NPTE@2323|unclassified Bacteria 2|Bacteria S Capsule biosynthesis CapC capC - - ko:K22116 - - - - ko00000 - - - Caps_synth_CapC k59_1494721_2 283942.IL2400 7.7e-62 206.0 COG0769@1|root,COG0769@2|Bacteria,1QYFB@1224|Proteobacteria,1T3Q5@1236|Gammaproteobacteria,2QGQ5@267893|Idiomarinaceae 1236|Gammaproteobacteria M Mur ligase middle domain - - - ko:K01932 - - - - ko00000,ko01000 - - - Mur_ligase_M k59_861484_1 469383.Cwoe_5528 2.17e-92 286.0 COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CPHH@84995|Rubrobacteria 84995|Rubrobacteria I Carboxyl transferase domain - - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1647964_1 869210.Marky_0500 1.62e-34 130.0 COG2133@1|root,COG2133@2|Bacteria,1WJQY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G PFAM Glucose Sorbosone dehydrogenase - - - - - - - - - - - - GSDH k59_339395_1 290315.Clim_1318 1.21e-80 250.0 COG0265@1|root,COG0265@2|Bacteria 2|Bacteria O serine-type endopeptidase activity - - - - - - - - - - - - FHA,Trypsin,Trypsin_2 k59_1494728_1 272624.lpg0323 5.96e-94 305.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1JD5C@118969|Legionellales 118969|Legionellales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1592343_1 1232410.KI421421_gene3319 6.63e-12 71.6 COG2897@1|root,COG2897@2|Bacteria,1RFF7@1224|Proteobacteria,42RW9@68525|delta/epsilon subdivisions,2WNRM@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_287189_1 555778.Hneap_1444 3.45e-29 119.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1WWER@135613|Chromatiales 135613|Chromatiales M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_445192_1 1122135.KB893135_gene1031 1.81e-51 177.0 28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,2TUAV@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1494743_1 765912.Thimo_0971 2.6e-31 115.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria,1WX5I@135613|Chromatiales 135613|Chromatiales J Belongs to the SUA5 family - - - - - - - - - - - - Sua5_yciO_yrdC k59_1494743_2 338969.Rfer_2159 5.92e-15 73.2 COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,2WFQP@28216|Betaproteobacteria,4ABHJ@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM Conserved TM helix repeat-containing protein - - - - - - - - - - - - TM_helix k59_964940_1 330214.NIDE0422 1.48e-25 102.0 COG0287@1|root,COG0287@2|Bacteria,3J0SQ@40117|Nitrospirae 40117|Nitrospirae C Prephenate dehydrogenase - - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_964940_2 330214.NIDE0421 4.86e-58 188.0 COG2876@1|root,COG2876@2|Bacteria,3J0A5@40117|Nitrospirae 40117|Nitrospirae E NeuB family - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_1170901_1 525904.Tter_0021 5.86e-06 51.6 COG0304@1|root,COG0304@2|Bacteria,2NNSX@2323|unclassified Bacteria 2|Bacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabB - 2.3.1.179,2.3.1.41 ko:K00647,ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1170901_2 1122244.AUGF01000003_gene900 1.22e-08 53.1 COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,1S8X4@1236|Gammaproteobacteria,3NPBD@468|Moraxellaceae 1236|Gammaproteobacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0050896,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_964942_1 113395.AXAI01000004_gene4406 7.83e-80 248.0 COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2TU3A@28211|Alphaproteobacteria,3JW29@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MA20_06335 - 4.2.1.156,4.2.1.42,5.1.2.2 ko:K01781,ko:K20023 ko00053,ko00627,ko01120,map00053,map00627,map01120 - R03791,R04161,R05608 RC00543,RC00998 ko00000,ko00001,ko01000 - - - MR_MLE_C,MR_MLE_N k59_287203_1 3983.cassava4.1_005801m 2.81e-13 74.7 COG0500@1|root,KOG1269@2759|Eukaryota,37MW5@33090|Viridiplantae,3G8XR@35493|Streptophyta,4JH7B@91835|fabids 35493|Streptophyta I Phosphoethanolamine N-methyltransferase - GO:0000003,GO:0000902,GO:0000904,GO:0001505,GO:0003006,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006629,GO:0006644,GO:0006650,GO:0006656,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0007275,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008610,GO:0008654,GO:0008757,GO:0009058,GO:0009308,GO:0009309,GO:0009555,GO:0009605,GO:0009653,GO:0009791,GO:0009826,GO:0009856,GO:0009860,GO:0009932,GO:0009987,GO:0010183,GO:0016043,GO:0016049,GO:0016740,GO:0016741,GO:0019637,GO:0019695,GO:0022414,GO:0022622,GO:0030154,GO:0032259,GO:0032501,GO:0032502,GO:0032989,GO:0034641,GO:0040007,GO:0040011,GO:0042133,GO:0042136,GO:0042221,GO:0042330,GO:0042401,GO:0042425,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044706,GO:0045017,GO:0046470,GO:0046474,GO:0046486,GO:0048229,GO:0048364,GO:0048468,GO:0048528,GO:0048588,GO:0048589,GO:0048731,GO:0048856,GO:0048868,GO:0048869,GO:0050896,GO:0050918,GO:0051704,GO:0052667,GO:0060560,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0090407,GO:0090696,GO:0097164,GO:0099402,GO:1901564,GO:1901566,GO:1901576 2.1.1.103 ko:K05929 ko00564,map00564 - R02037,R06868,R06869 RC00003,RC00060,RC00181,RC00496 ko00000,ko00001,ko01000 - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 k59_1441081_1 396588.Tgr7_1438 2.77e-177 502.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RQBM@1236|Gammaproteobacteria,1WWV0@135613|Chromatiales 135613|Chromatiales E aminotransferase class I and II - - - ko:K14261 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_1070687_1 760568.Desku_2843 1.76e-122 369.0 COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24BRX@186801|Clostridia,260H8@186807|Peptococcaceae 186801|Clostridia H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_234083_1 909663.KI867149_gene3384 7.3e-32 121.0 2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,42QRD@68525|delta/epsilon subdivisions,2WMYW@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function (DUF4197) - - - - - - - - - - - - DUF4197 k59_234083_2 472759.Nhal_3460 1.56e-38 140.0 COG1988@1|root,COG1988@2|Bacteria,1R5QP@1224|Proteobacteria,1S64C@1236|Gammaproteobacteria,1X05J@135613|Chromatiales 135613|Chromatiales S membrane-bound metal-dependent - - - ko:K07038 - - - - ko00000 - - - YdjM k59_132476_1 340099.Teth39_0880 1.3e-39 148.0 COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,42EZ2@68295|Thermoanaerobacterales 186801|Clostridia P ATPases associated with a variety of cellular activities - - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran k59_85514_1 1379281.AVAG01000043_gene294 9.94e-53 182.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42P5W@68525|delta/epsilon subdivisions,2WMA6@28221|Deltaproteobacteria,2M8GP@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Peptidase M23 - - - - - - - - - - - - Peptidase_M23 k59_85514_2 404380.Gbem_1526 6.71e-14 71.6 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1231635_1 1247726.MIM_c05310 3.3e-38 140.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,3T1WP@506|Alcaligenaceae 28216|Betaproteobacteria S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_1017765_1 880072.Desac_2709 3.73e-82 262.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,42NYT@68525|delta/epsilon subdivisions,2WIM3@28221|Deltaproteobacteria,2MQVI@213462|Syntrophobacterales 28221|Deltaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_445231_1 411902.CLOBOL_00366 9.82e-60 205.0 COG4690@1|root,COG4690@2|Bacteria,1V44V@1239|Firmicutes 1239|Firmicutes E Peptidase family C69 - - - ko:K14358 - - - - ko00000,ko01002 - - - Peptidase_C69 k59_339446_1 1229909.NSED_09480 4.13e-64 209.0 COG0475@1|root,arCOG01953@2157|Archaea,41T00@651137|Thaumarchaeota 2157|Archaea P Sodium hydrogen exchanger napA - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger k59_445238_2 1121374.KB891575_gene1244 3.47e-56 184.0 2BKN5@1|root,32F3J@2|Bacteria,1RIMC@1224|Proteobacteria,1S6Q3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bacterial protein of unknown function (Gcw_chp) - - - - - - - - - - - - Gcw_chp k59_287229_1 105420.BBPO01000006_gene3022 5.97e-27 103.0 COG1545@1|root,COG1545@2|Bacteria,2IHZR@201174|Actinobacteria,2NIFG@228398|Streptacidiphilus 201174|Actinobacteria S Rubredoxin-like zinc ribbon domain (DUF35_N) - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_287229_2 1121374.KB891575_gene1044 2.13e-20 91.3 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,1RXYY@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q cytochrome p450 - - - - - - - - - - - - p450 k59_660271_1 1121479.AUBS01000019_gene2809 7.22e-22 95.9 COG0475@1|root,COG0475@2|Bacteria,1MVGV@1224|Proteobacteria,2TUCH@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Sodium hydrogen exchanger - - - - - - - - - - - - Na_H_Exchanger k59_660271_2 552811.Dehly_0432 2.77e-18 83.6 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1 k59_817356_1 1337936.IJ00_22865 1.15e-05 52.0 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CBS,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_392802_1 517418.Ctha_0720 2.85e-32 114.0 COG2119@1|root,COG2119@2|Bacteria,1FFN7@1090|Chlorobi 1090|Chlorobi S Uncharacterized protein family UPF0016 - - - - - - - - - - - - UPF0016 k59_392802_2 1680.BADO_1424 0.000142 44.3 COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4CZ24@85004|Bifidobacteriales 201174|Actinobacteria P E1-E2 ATPase - - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - Cupredoxin_1,E1-E2_ATPase,HMA,Hydrolase,YHS k59_1287357_1 330214.NIDE1203 3.99e-58 189.0 COG0596@1|root,COG0596@2|Bacteria 2|Bacteria S hydrolase activity, acting on ester bonds - - 3.8.1.5 ko:K01563 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 - - - Abhydrolase_1,Abhydrolase_4 k59_1287357_2 330214.NIDE1204 2.49e-10 62.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,3J10I@40117|Nitrospirae 40117|Nitrospirae C Conserved carboxylase domain - - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_11800_1 316067.Geob_2894 2.2e-119 355.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2WJ2E@28221|Deltaproteobacteria,43TS7@69541|Desulfuromonadales 28221|Deltaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_11801_1 393595.ABO_1041 5.25e-25 105.0 COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,1XIQ4@135619|Oceanospirillales 135619|Oceanospirillales S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_861560_1 396588.Tgr7_0954 1.6e-41 147.0 COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,1RS4G@1236|Gammaproteobacteria,1WXQH@135613|Chromatiales 135613|Chromatiales Q PFAM methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_1441149_2 1379270.AUXF01000006_gene13 5.54e-42 148.0 COG1087@1|root,COG1087@2|Bacteria,1ZSX3@142182|Gemmatimonadetes 142182|Gemmatimonadetes M 3-beta hydroxysteroid dehydrogenase/isomerase family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_132527_1 1121438.JNJA01000004_gene742 9.08e-17 80.9 2E6CS@1|root,3310E@2|Bacteria,1N2FR@1224|Proteobacteria,42UY2@68525|delta/epsilon subdivisions,2WPMU@28221|Deltaproteobacteria,2M8VJ@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_132527_2 1168065.DOK_04643 1.86e-17 80.5 2BFQ0@1|root,329II@2|Bacteria,1RJTQ@1224|Proteobacteria,1T0TX@1236|Gammaproteobacteria,1J6WM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_1170949_1 1348657.M622_11685 1.62e-115 340.0 COG2141@1|root,COG2141@2|Bacteria,1R9CH@1224|Proteobacteria 1224|Proteobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_1648083_1 469610.HMPREF0189_00164 8.59e-07 51.2 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,1KISW@119065|unclassified Burkholderiales 28216|Betaproteobacteria E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1648083_2 330214.NIDE3383 4.63e-83 257.0 COG0493@1|root,COG0493@2|Bacteria,3J152@40117|Nitrospirae 40117|Nitrospirae C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4,Fer4_20,GXGXG,Pyr_redox_2,Pyr_redox_3 k59_287266_2 1184607.AUCHE_03_00560 1.78e-13 66.6 COG0199@1|root,COG0199@2|Bacteria,2IKN9@201174|Actinobacteria,4F79E@85018|Dermatophilaceae 201174|Actinobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_234141_1 994479.GL877878_gene2593 1.48e-37 145.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,2GKBW@201174|Actinobacteria,4E0GX@85010|Pseudonocardiales 201174|Actinobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.8 ko:K00179,ko:K04090 - - - - br01601,ko00000,ko01000 - - - Fer4,POR,POR_N,TPP_enzyme_C k59_1231699_1 745014.OMB55_00012900 1.82e-38 141.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,1J52J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF885 k59_1231699_2 526222.Desal_2813 3.13e-19 85.9 COG0189@1|root,COG0189@2|Bacteria,1MVDU@1224|Proteobacteria,42MVH@68525|delta/epsilon subdivisions,2WMHB@28221|Deltaproteobacteria,2M9JX@213115|Desulfovibrionales 28221|Deltaproteobacteria HJ Sugar-transfer associated ATP-grasp - - - - - - - - - - - - ATPgrasp_ST k59_1070744_1 365046.Rta_32440 1.69e-78 260.0 COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VK1K@28216|Betaproteobacteria,4AASY@80864|Comamonadaceae 28216|Betaproteobacteria C Indolepyruvate ferredoxin oxidoreductase - - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - TPP_enzyme_C k59_85582_1 1131266.ARWQ01000028_gene1019 6.26e-47 155.0 COG1730@1|root,arCOG01341@2157|Archaea,41SSP@651137|Thaumarchaeota 651137|Thaumarchaeota O Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding pfdA - - ko:K04797 - - - - ko00000,ko03110 - - - Prefoldin k59_85582_2 1229909.NSED_01910 1.75e-12 66.2 COG0552@1|root,arCOG01227@2157|Archaea,41SCC@651137|Thaumarchaeota 651137|Thaumarchaeota U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_817406_1 1463934.JOCF01000021_gene1677 1.44e-14 70.9 COG0350@1|root,COG0350@2|Bacteria,2GKA9@201174|Actinobacteria 201174|Actinobacteria L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated ogt - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,Methyltransf_1N k59_817406_2 247633.GP2143_04343 1.45e-119 352.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1J4VV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D recombinase XerD xerD GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_1170964_1 1131266.ARWQ01000002_gene512 3.05e-76 246.0 COG0644@1|root,COG2440@1|root,arCOG00570@2157|Archaea,arCOG01984@2157|Archaea,41SXJ@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - ko:K00313 - - - - ko00000,ko01000 - - - - k59_1287417_1 240016.ABIZ01000001_gene1506 6.46e-58 188.0 COG4149@1|root,COG4149@2|Bacteria,46TVT@74201|Verrucomicrobia,2IUID@203494|Verrucomicrobiae 203494|Verrucomicrobiae P Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 k59_817431_1 985867.AEWF01000004_gene84 5.36e-66 214.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,47F4J@766|Rickettsiales 766|Rickettsiales P ABC transporter potA - 3.6.3.30 ko:K02010,ko:K11076 ko02010,map02010 M00190,M00300 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10,3.A.1.11.2 - - ABC_tran,TOBE_2 k59_1170969_1 1265313.HRUBRA_00544 6.19e-119 362.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1J54K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdZ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1122682_1 1144275.COCOR_03897 4.14e-78 234.0 COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,42RHI@68525|delta/epsilon subdivisions,2WNGV@28221|Deltaproteobacteria,2YV1R@29|Myxococcales 28221|Deltaproteobacteria F deaminase comEB - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_661739_2 1125863.JAFN01000001_gene2919 4.4e-53 178.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2WKX1@28221|Deltaproteobacteria 28221|Deltaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1533853_1 314278.NB231_13921 7.37e-22 99.8 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria,1WVVR@135613|Chromatiales 135613|Chromatiales M PFAM glycosyl transferase family 9 - - - ko:K02841 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_1496306_1 1168065.DOK_15069 6.96e-36 132.0 COG2141@1|root,COG2141@2|Bacteria,1R7K1@1224|Proteobacteria,1RNSC@1236|Gammaproteobacteria,1J5HQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_1533866_1 95619.PM1_0204710 4.42e-61 202.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063,iJN746.PP_4889 Adenylsucc_synt k59_86714_1 349521.HCH_01805 5.13e-121 352.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1XHJW@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the cysteine synthase cystathionine beta- synthase family cysM - 2.5.1.47 ko:K12339 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03132,R03601,R04859 RC00020,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_818902_1 309807.SRU_0676 5.34e-07 51.6 COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,1FK0T@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes T Universal stress protein family - - - - - - - - - - - - Usp k59_818902_2 557599.MKAN_18560 2.78e-56 197.0 COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,232MQ@1762|Mycobacteriaceae 201174|Actinobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC ctpF GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.8 ko:K01537,ko:K12953 - - - - ko00000,ko01000 3.A.3,3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_915087_1 744979.R2A130_2974 1.9e-34 137.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_133680_1 321327.CYA_2395 1.82e-49 171.0 COG1304@1|root,COG1304@2|Bacteria,1G2KC@1117|Cyanobacteria,1GZQP@1129|Synechococcus 1117|Cyanobacteria C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) fni - 5.3.3.2 ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01123 RC00455 ko00000,ko00001,ko00002,ko01000 - - - FMN_dh k59_661773_1 1211815.CBYP010000063_gene1912 9.14e-140 416.0 COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria 201174|Actinobacteria I carboxylase - - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_707303_1 330214.NIDE2913 2.15e-109 326.0 COG0148@1|root,COG0148@2|Bacteria,3J0DB@40117|Nitrospirae 40117|Nitrospirae G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_1496324_1 330214.NIDE0344 3.27e-97 291.0 COG0714@1|root,COG0714@2|Bacteria,3J0WQ@40117|Nitrospirae 40117|Nitrospirae S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_757516_1 86106.I862_06260 8.12e-72 223.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2TRQH@28211|Alphaproteobacteria,47F8N@766|Rickettsiales 766|Rickettsiales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_1449818_1 1134413.ANNK01000087_gene253 5.02e-98 300.0 COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,4HM1D@91061|Bacilli,1ZR0K@1386|Bacillus 91061|Bacilli H Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate yclC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044464 4.1.1.61 ko:K01612 ko00627,ko01120,ko01220,map00627,map01120,map01220 - R01238 RC00391 ko00000,ko00001,ko01000 - - - UbiD k59_514504_1 483219.LILAB_12495 5.49e-07 56.2 COG3781@1|root,COG3781@2|Bacteria,1MX91@1224|Proteobacteria,434DU@68525|delta/epsilon subdivisions,2X8U6@28221|Deltaproteobacteria,2Z0EB@29|Myxococcales 28221|Deltaproteobacteria S Bestrophin, RFP-TM, chloride channel - - - ko:K08994 - - - - ko00000,ko02000 1.A.46.2 - - Bestrophin k59_1391265_1 314345.SPV1_00997 4.49e-15 72.0 2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1661227_1 1535422.ND16A_3450 7.36e-60 193.0 COG0625@1|root,COG0625@2|Bacteria,1RAIN@1224|Proteobacteria,1S3Q5@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the GST superfamily - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_1600669_1 330214.NIDE2677 4.82e-21 84.3 COG0227@1|root,COG0227@2|Bacteria,3J0VJ@40117|Nitrospirae 40117|Nitrospirae J Belongs to the bacterial ribosomal protein bL28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k59_1600669_2 1144305.PMI02_03717 1.34e-12 65.9 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2UGES@28211|Alphaproteobacteria,2K75R@204457|Sphingomonadales 204457|Sphingomonadales J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_1507955_1 1416760.AYMS01000072_gene3481 2.62e-18 92.0 COG0427@1|root,COG0427@2|Bacteria,4NFS3@976|Bacteroidetes,1HWJT@117743|Flavobacteriia,47IX1@76831|Myroides 976|Bacteroidetes C Acetyl-CoA hydrolase/transferase N-terminal domain cat2 - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_298611_1 227377.CBU_1866 3.13e-50 179.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1JCZG@118969|Legionellales 118969|Legionellales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_514514_1 224325.AF_2266 3.08e-16 82.8 COG0491@1|root,arCOG00498@2157|Archaea 2157|Archaea S COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B k59_830528_2 330214.NIDE4172 4.2e-110 325.0 COG0451@1|root,COG0451@2|Bacteria,3J0ZC@40117|Nitrospirae 40117|Nitrospirae M Male sterility protein - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_1661235_1 402881.Plav_1398 1.99e-87 263.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,2TUXR@28211|Alphaproteobacteria 28211|Alphaproteobacteria N ABC transporter permease - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3 k59_1242481_1 998674.ATTE01000001_gene4168 5.07e-67 228.0 COG1196@1|root,COG1196@2|Bacteria,1MVMQ@1224|Proteobacteria,1S2MH@1236|Gammaproteobacteria 1236|Gammaproteobacteria D nuclear chromosome segregation - - - - - - - - - - - - - k59_830531_1 330214.NIDE0232 4.23e-134 404.0 COG3383@1|root,COG3383@2|Bacteria,3J0UR@40117|Nitrospirae 2|Bacteria C Molydopterin dinucleotide binding domain hcnA - 1.4.99.5,1.5.3.1 ko:K00302,ko:K10814 ko00260,ko00460,ko01100,ko01110,map00260,map00460,map01100,map01110 - R00374,R00610,R05704 RC00060,RC00557,RC02808 ko00000,ko00001,ko01000,ko02042 - - - Fer2_4 k59_974284_1 247633.GP2143_15546 8.93e-13 75.1 COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,1SDRJ@1236|Gammaproteobacteria,1J73J@118884|unclassified Gammaproteobacteria 1224|Proteobacteria S metal-dependent hydrolase of the TIM-barrel fold MA20_19310 - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_974284_2 1205680.CAKO01000040_gene1084 3.35e-28 112.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria,2JRI5@204441|Rhodospirillales 204441|Rhodospirillales P Flavin-binding monooxygenase-like - - - - - - - - - - - - FMO-like k59_143246_2 880072.Desac_0744 5.58e-35 120.0 COG1837@1|root,COG1837@2|Bacteria,1N7IX@1224|Proteobacteria,42TXI@68525|delta/epsilon subdivisions,2WQBS@28221|Deltaproteobacteria,2MQIW@213462|Syntrophobacterales 28221|Deltaproteobacteria S KH domain - - - ko:K06960 - - - - ko00000 - - - KH_4 k59_143246_3 1232410.KI421421_gene3841 2.56e-08 52.0 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,42V30@68525|delta/epsilon subdivisions,2WRH7@28221|Deltaproteobacteria,43SNJ@69541|Desulfuromonadales 28221|Deltaproteobacteria J Ribosomal protein S16 rpsP GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_715783_1 419610.Mext_0495 5.67e-19 94.0 COG2199@1|root,COG3706@2|Bacteria,1MX83@1224|Proteobacteria,2U3QQ@28211|Alphaproteobacteria,1JSQD@119045|Methylobacteriaceae 28211|Alphaproteobacteria T Cache domain - - - - - - - - - - - - GGDEF,dCache_1 k59_243692_1 396588.Tgr7_0458 9.74e-37 142.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1WYS8@135613|Chromatiales 135613|Chromatiales KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - HAMP,HEAT_2,Pkinase,sCache_3_2 k59_1541056_1 583355.Caka_2622 2.06e-74 237.0 COG3659@1|root,COG3659@2|Bacteria 2|Bacteria M wide pore channel activity - - - ko:K07267 - - - - ko00000,ko02000 1.B.19.1 - - OprB k59_1179638_1 46429.BV95_03448 2.06e-59 204.0 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2U1SP@28211|Alphaproteobacteria,2K9B1@204457|Sphingomonadales 204457|Sphingomonadales C Cytochrome C oxidase, cbb3-type, subunit III - - 1.1.9.1 ko:K17760 - - - - ko00000,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_1661272_1 1232410.KI421422_gene2026 1.03e-46 158.0 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,42N6I@68525|delta/epsilon subdivisions,2WK7S@28221|Deltaproteobacteria,43SF9@69541|Desulfuromonadales 28221|Deltaproteobacteria L endonuclease III nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_1335857_1 395493.BegalDRAFT_3225 1.83e-90 277.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,1RQAK@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Isocitrate lyase aceA GO:0003674,GO:0003824,GO:0004451,GO:0005488,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046487,GO:0071704 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - e_coli_core.b4015,iAF1260.b4015,iB21_1397.B21_03847,iBWG_1329.BWG_3671,iE2348C_1286.E2348C_4318,iEC042_1314.EC042_4377,iEC55989_1330.EC55989_4500,iECABU_c1320.ECABU_c45310,iECBD_1354.ECBD_4022,iECB_1328.ECB_03887,iECDH10B_1368.ECDH10B_4204,iECDH1ME8569_1439.ECDH1ME8569_3871,iECD_1391.ECD_03887,iECED1_1282.ECED1_4722,iECIAI1_1343.ECIAI1_4235,iECIAI39_1322.ECIAI39_4401,iECNA114_1301.ECNA114_4164,iECO103_1326.ECO103_4759,iECO111_1330.ECO111_4827,iECO26_1355.ECO26_5119,iECP_1309.ECP_4225,iECSE_1348.ECSE_4300,iECSF_1327.ECSF_3865,iECUMN_1333.ECUMN_4541,iECW_1372.ECW_m4374,iEKO11_1354.EKO11_4310,iETEC_1333.ETEC_4270,iEcDH1_1363.EcDH1_3982,iEcE24377_1341.EcE24377A_4557,iEcHS_1320.EcHS_A4249,iEcSMS35_1347.EcSMS35_4469,iEcolC_1368.EcolC_4015,iJN746.PP_4116,iJO1366.b4015,iJR904.b4015,iLF82_1304.LF82_0012,iNRG857_1313.NRG857_20015,iSDY_1059.SDY_4328,iUMNK88_1353.UMNK88_4859,iWFL_1372.ECW_m4374,iY75_1357.Y75_RS20880 ICL k59_1661278_1 886293.Sinac_1825 3.63e-61 203.0 COG2256@1|root,COG2256@2|Bacteria,2IX8G@203682|Planctomycetes 203682|Planctomycetes L ATPase related to the helicase subunit of the Holliday junction resolvase - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_830580_1 29581.BW37_05534 4.33e-75 246.0 COG3590@1|root,COG3590@2|Bacteria,1QQ5Q@1224|Proteobacteria,2WGPB@28216|Betaproteobacteria,475IP@75682|Oxalobacteraceae 28216|Betaproteobacteria O peptidase - - - - - - - - - - - - - k59_456398_1 929703.KE386491_gene26 1.22e-81 256.0 COG2010@1|root,COG2010@2|Bacteria,4NHQV@976|Bacteroidetes,47N6X@768503|Cytophagia 976|Bacteroidetes C Cytochrome c - - - - - - - - - - - - Cytochrom_C k59_350768_1 395494.Galf_2533 0.000891 41.2 COG3012@1|root,COG3012@2|Bacteria,1MZZK@1224|Proteobacteria 1224|Proteobacteria S Belongs to the UPF0225 family ychJ - - ko:K09858 - - - - ko00000 - - - SEC-C k59_1082288_1 1292020.H483_0117445 1.55e-39 152.0 COG4584@1|root,COG4584@2|Bacteria,2GM4J@201174|Actinobacteria 201174|Actinobacteria L Transposase - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - rve k59_1335875_2 1123023.JIAI01000002_gene5308 2.4e-98 301.0 COG1575@1|root,COG1575@2|Bacteria,2IPQ8@201174|Actinobacteria 201174|Actinobacteria H Belongs to the MenA family. Type 1 subfamily - - - - - - - - - - - - UbiA k59_1449874_1 1167006.UWK_01840 6.08e-11 67.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C,Acyltransferase,PP-binding k59_1179665_1 525368.HMPREF0591_0025 6.3e-46 162.0 COG0425@1|root,COG0425@2|Bacteria,2I4E3@201174|Actinobacteria,23B3Y@1762|Mycobacteriaceae 201174|Actinobacteria O Belongs to the sulfur carrier protein TusA family - - - - - - - - - - - - - k59_514605_1 1123377.AUIV01000001_gene951 1.25e-58 186.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,1S3WS@1236|Gammaproteobacteria,1X6DH@135614|Xanthomonadales 135614|Xanthomonadales J binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_1082295_1 1123371.ATXH01000029_gene45 5.34e-143 427.0 COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,2GH2W@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria G Trehalose-phosphatase - - 2.4.1.15,3.1.3.12 ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,Trehalose_PPase k59_830620_1 936455.KI421499_gene36 3.29e-81 256.0 COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,3JX12@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C FAD dependent oxidoreductase - - - ko:K13796 - - - - ko00000 - - - FAD_binding_2 k59_1391335_1 1300143.CCAV010000006_gene4342 3.66e-25 103.0 2A78P@1|root,30W55@2|Bacteria,4P61W@976|Bacteroidetes,1IA4D@117743|Flavobacteriia,3ZTPU@59732|Chryseobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_261300_1 595460.RRSWK_05468 1.02e-44 166.0 COG0412@1|root,COG1554@1|root,COG0412@2|Bacteria,COG1554@2|Bacteria,2J2CS@203682|Planctomycetes 203682|Planctomycetes Q Acetyl xylan esterase (AXE1) - - - - - - - - - - - - AXE1,DLH k59_52399_1 1121015.N789_03380 6.63e-34 134.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1X50J@135614|Xanthomonadales 135614|Xanthomonadales E Asparagine synthase asnB2 - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_52399_2 1122917.KB899662_gene2136 1.7e-10 61.2 COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,4HDN8@91061|Bacilli,275I6@186822|Paenibacillaceae 91061|Bacilli E Belongs to the DegT DnrJ EryC1 family - - 2.6.1.102 ko:K13010 ko00520,map00520 - R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k59_261304_1 483219.LILAB_27685 2.96e-15 80.5 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2WIQ7@28221|Deltaproteobacteria,2YTZJ@29|Myxococcales 28221|Deltaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_238_1 1048834.TC41_0334 7.29e-129 376.0 COG0667@1|root,COG0667@2|Bacteria,1TPIY@1239|Firmicutes,4HA4Q@91061|Bacilli,278WZ@186823|Alicyclobacillaceae 91061|Bacilli C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_679241_1 1382306.JNIM01000001_gene545 2.81e-16 80.5 COG0421@1|root,COG0421@2|Bacteria,2G7ED@200795|Chloroflexi 200795|Chloroflexi E Spermidine synthase tetramerisation domain - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth k59_731421_1 301.JNHE01000029_gene716 1.05e-65 213.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,1RPPD@1236|Gammaproteobacteria,1YDBV@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Peptidase dimerisation domain - - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1462703_1 28258.KP05_09290 2.18e-73 236.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1XH5E@135619|Oceanospirillales 135619|Oceanospirillales C 2-oxoglutarate dehydrogenase complex lpdG - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_104578_1 404589.Anae109_2488 1.42e-72 243.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2WJ76@28221|Deltaproteobacteria,2YUHH@29|Myxococcales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_470245_1 1033802.SSPSH_000631 9.07e-47 162.0 COG0258@1|root,COG0258@2|Bacteria,1RAAR@1224|Proteobacteria,1S2FH@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG0258 5'-3' exonuclease (including N-terminal domain of PolI) - - - - - - - - - - - - 5_3_exonuc,5_3_exonuc_N k59_992614_2 357808.RoseRS_0893 1.07e-91 284.0 COG3677@1|root,COG3677@2|Bacteria,2G6SJ@200795|Chloroflexi,3772U@32061|Chloroflexia 32061|Chloroflexia L PFAM Transposase IS66 family - - - - - - - - - - - - - k59_627021_1 765913.ThidrDRAFT_1611 3.07e-81 258.0 COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,1RQPH@1236|Gammaproteobacteria,1WX21@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_209076_1 1049564.TevJSym_ac01410 7.16e-69 213.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1J63Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression dksA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_209076_2 1163617.SCD_n02324 1.31e-47 161.0 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria 28216|Betaproteobacteria J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon gluQ - - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c k59_365851_1 795359.TOPB45_0780 7.66e-17 77.0 COG0522@1|root,COG0522@2|Bacteria,2GGS1@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_365851_2 706587.Desti_5288 1.22e-47 162.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2WJ5K@28221|Deltaproteobacteria,2MR47@213462|Syntrophobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_1306012_1 243233.MCA1363 5.9e-15 76.3 COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,1RQMV@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis rodZ GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - ko:K15539 - - - - ko00000 - - - DUF4115,HTH_25 k59_783708_1 530564.Psta_4082 3.55e-26 113.0 COG3209@1|root,COG4932@1|root,COG3209@2|Bacteria,COG4932@2|Bacteria,2IYH3@203682|Planctomycetes 203682|Planctomycetes M domain protein - - - - - - - - - - - - Dockerin_1,SdrD_B k59_992621_1 640511.BC1002_6148 6.3e-12 68.9 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VR5K@28216|Betaproteobacteria,1K265@119060|Burkholderiaceae 28216|Betaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_835921_1 483219.LILAB_22820 1.4e-05 54.3 COG0457@1|root,COG0484@1|root,COG0457@2|Bacteria,COG0484@2|Bacteria,1MVIW@1224|Proteobacteria,43C2N@68525|delta/epsilon subdivisions,2X7D8@28221|Deltaproteobacteria,2YVWI@29|Myxococcales 28221|Deltaproteobacteria O DnaJ molecular chaperone homology domain - - - - - - - - - - - - DnaJ,TPR_8 k59_835921_2 1307759.JOMJ01000004_gene2863 3.28e-141 407.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WKXU@28221|Deltaproteobacteria,2M80I@213115|Desulfovibrionales 28221|Deltaproteobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_52435_1 1121935.AQXX01000114_gene3292 1.47e-78 251.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria,1XHAP@135619|Oceanospirillales 135619|Oceanospirillales I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_268_2 994479.GL877878_gene2876 9.46e-81 259.0 COG0530@1|root,COG0530@2|Bacteria,2GP6H@201174|Actinobacteria,4E18G@85010|Pseudonocardiales 201174|Actinobacteria P PFAM sodium calcium exchanger - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_156827_1 387631.Asulf_00746 0.000186 45.1 COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,2472U@183980|Archaeoglobi 183980|Archaeoglobi L Belongs to the UPF0215 family - - - ko:K09120 - - - - ko00000 - - - DUF99 k59_156827_2 637905.SVI_3140 1.92e-30 114.0 COG1764@1|root,COG1764@2|Bacteria,1RI5C@1224|Proteobacteria,1T04C@1236|Gammaproteobacteria,2QBU7@267890|Shewanellaceae 1236|Gammaproteobacteria O PFAM OsmC family protein - - - - - - - - - - - - OsmC k59_1306019_1 1047013.AQSP01000125_gene2615 8.96e-91 282.0 COG2252@1|root,COG2252@2|Bacteria,2NNZ2@2323|unclassified Bacteria 2|Bacteria S Permease family pbuG GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006863,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015205,GO:0015207,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015851,GO:0015853,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098655,GO:0098660,GO:0098662,GO:1902600,GO:1904823 - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - iECH74115_1262.ECH74115_5145,iECOK1_1307.ECOK1_4117,iECSP_1301.ECSP_4762,iECUMN_1333.ECUMN_4191,iECs_1301.ECs4651,iG2583_1286.G2583_4505,iJO1366.b3714,iUTI89_1310.UTI89_C4220,iY75_1357.Y75_RS18500,iYO844.BSU06370,iZ_1308.Z5209 Xan_ur_permease k59_209092_1 338966.Ppro_3708 1.93e-72 229.0 COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria 1224|Proteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_1514918_1 66874.JOFS01000015_gene6687 2.93e-12 71.2 COG0515@1|root,COG0515@2|Bacteria,2IKPQ@201174|Actinobacteria 201174|Actinobacteria KLT Domain of unknown function (DUF4328) - - - - - - - - - - - - DUF4328 k59_835933_1 391589.RGAI101_43 1.89e-12 70.1 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,2P23I@2433|Roseobacter 28211|Alphaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane - - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SecA_DEAD,SecA_PP_bind k59_783731_1 391589.RGAI101_1145 4.51e-66 214.0 COG1812@1|root,COG1812@2|Bacteria,1QPB9@1224|Proteobacteria,2U1WE@28211|Alphaproteobacteria 28211|Alphaproteobacteria E S-adenosylmethionine synthetase (AdoMet synthetase) - - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_Synthase k59_1149325_2 985054.JQEZ01000003_gene1303 1.78e-16 79.0 COG0402@1|root,COG0402@2|Bacteria,1MX34@1224|Proteobacteria,2U0IN@28211|Alphaproteobacteria,4NBRI@97050|Ruegeria 28211|Alphaproteobacteria F Amidohydrolase family codA - 3.5.4.1 ko:K01485 ko00240,ko00330,ko01100,map00240,map00330,map01100 - R00974,R01411,R02922 RC00074,RC00514,RC00809 ko00000,ko00001,ko01000 - - - Amidohydro_3 k59_992649_2 28583.AMAG_14124T0 1.61e-29 116.0 COG1024@1|root,KOG1680@2759|Eukaryota,3A247@33154|Opisthokonta,3PGGH@4751|Fungi 33154|Opisthokonta I Belongs to the enoyl-CoA hydratase isomerase family - - - - - - - - - - - - ECH_1 k59_209100_1 477228.YO5_00805 1.32e-43 157.0 COG3975@1|root,COG3975@2|Bacteria,1QX25@1224|Proteobacteria,1RWD8@1236|Gammaproteobacteria,1Z0MA@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S protease with the C-terminal PDZ domain - - - - - - - - - - - - - k59_313573_1 316273.XCV2696 4.64e-17 80.1 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1X3J5@135614|Xanthomonadales 135614|Xanthomonadales J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_209104_1 713587.THITH_02640 1.6e-80 251.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales 135613|Chromatiales C Cysteine-rich domain - - - - - - - - - - - - CCG k59_418053_1 909663.KI867150_gene2649 5.98e-11 67.8 COG1239@1|root,COG1239@2|Bacteria,1MVD4@1224|Proteobacteria,42NRR@68525|delta/epsilon subdivisions,2WJDX@28221|Deltaproteobacteria,2MQ4Z@213462|Syntrophobacterales 28221|Deltaproteobacteria H PFAM Magnesium chelatase, subunit ChlI - - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - - Mg_chelatase k59_156839_1 1122137.AQXF01000002_gene273 1.44e-53 172.0 2CD0I@1|root,32RWS@2|Bacteria,1N0MC@1224|Proteobacteria,2U9CM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF4399) - - - - - - - - - - - - DUF4399 k59_156839_2 1178482.BJB45_13675 7.17e-34 131.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1XHA5@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_1416207_1 326427.Cagg_0732 4.61e-26 107.0 COG0477@1|root,COG2814@2|Bacteria,2G6D7@200795|Chloroflexi,3763C@32061|Chloroflexia 32061|Chloroflexia EGP major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_3 k59_1416207_2 1163617.SCD_n02062 9.63e-30 110.0 COG2920@1|root,COG2920@2|Bacteria,1NAQC@1224|Proteobacteria,2VWA3@28216|Betaproteobacteria 28216|Betaproteobacteria P DsrC like protein - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_1416207_3 713587.THITH_04055 7.1e-24 94.7 COG2932@1|root,COG2932@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - ko:K09384 - - - - ko00000 - - - DUF3427,HIT,HTH_31,Helicase_C,Methyltransf_25,PLDc_2,Peptidase_S24,ResIII k59_1469110_1 1142394.PSMK_16230 4.25e-89 276.0 COG0502@1|root,COG0502@2|Bacteria,2IXTG@203682|Planctomycetes 203682|Planctomycetes H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_841640_1 436308.Nmar_0522 5.54e-78 237.0 COG1354@1|root,arCOG02610@2157|Archaea,41SMU@651137|Thaumarchaeota 651137|Thaumarchaeota L chromosome segregation and condensation protein ScpA - - - ko:K05896 - - - - ko00000,ko03036 - - - - k59_634204_1 998674.ATTE01000001_gene2944 1.46e-05 49.3 COG1280@1|root,COG1280@2|Bacteria,1Q4CV@1224|Proteobacteria,1RQV8@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Lysine exporter protein (LYSE YGGA) - - - ko:K05834 - - - - ko00000,ko02000 2.A.76.1.1 - - LysE k59_1311610_1 1286106.MPL1_06507 2.41e-106 314.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RM9H@1236|Gammaproteobacteria,460AA@72273|Thiotrichales 72273|Thiotrichales Q ABC transporter permease - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_319758_1 1396141.BATP01000007_gene5531 9.06e-24 95.5 COG0377@1|root,COG0377@2|Bacteria,46SMM@74201|Verrucomicrobia,2ITJ6@203494|Verrucomicrobiae 203494|Verrucomicrobiae C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_319758_2 985255.APHJ01000031_gene2787 1.05e-24 102.0 COG1249@1|root,COG1249@2|Bacteria,4NDVC@976|Bacteroidetes,1HWVS@117743|Flavobacteriia,2P64Y@244698|Gillisia 976|Bacteroidetes C L-lysine 6-monooxygenase (NADPH-requiring) lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_1102942_1 1123508.JH636456_gene159 1.09e-81 253.0 COG3228@1|root,COG3228@2|Bacteria,2IZES@203682|Planctomycetes 203682|Planctomycetes S Belongs to the MtfA family - - - ko:K09933 - - - - ko00000,ko01002 - - - Peptidase_M90,SEC-C k59_109883_1 1177154.Y5S_00024 1.91e-63 203.0 COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,1RRS1@1236|Gammaproteobacteria,1XM0C@135619|Oceanospirillales 135619|Oceanospirillales G Haloacid dehalogenase-like hydrolase - - - ko:K02566 - - - - ko00000 - - - Hydrolase_6,Hydrolase_like k59_737096_1 658612.MD26_20770 1.04e-07 56.2 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria T signal-transduction protein containing cAMP-binding and CBS domains - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_737096_2 1380394.JADL01000010_gene4240 5.38e-42 145.0 COG2304@1|root,COG2304@2|Bacteria,1RA4S@1224|Proteobacteria,2U5T8@28211|Alphaproteobacteria,2JRP0@204441|Rhodospirillales 204441|Rhodospirillales S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_1261005_1 1125863.JAFN01000001_gene1223 5.1e-13 70.1 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,42NFP@68525|delta/epsilon subdivisions,2WK64@28221|Deltaproteobacteria 28221|Deltaproteobacteria EQ PFAM Hydantoinase oxoprolinase hyuA - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_1261005_2 469383.Cwoe_2132 8.48e-13 71.6 COG0146@1|root,COG0146@2|Bacteria,2IA3H@201174|Actinobacteria 201174|Actinobacteria EQ Hydantoinase B/oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_1625121_1 1454004.AW11_01686 1.98e-76 245.0 COG1295@1|root,COG1959@1|root,COG1295@2|Bacteria,COG1959@2|Bacteria,1QICW@1224|Proteobacteria,2VPV7@28216|Betaproteobacteria 28216|Betaproteobacteria K Virulence factor BrkB - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_1625121_2 396588.Tgr7_2113 4.28e-46 167.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WW1G@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_946403_1 396588.Tgr7_1268 1.78e-58 189.0 COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1S05R@1236|Gammaproteobacteria,1WXBW@135613|Chromatiales 135613|Chromatiales C nitrate reductase activity - - - - - - - - - - - - - k59_1625929_1 290318.Cvib_0103 3.89e-46 159.0 COG2801@1|root,COG2801@2|Bacteria 2|Bacteria L transposition - - - - - - - - - - - - HTH_21,HTH_32,rve,rve_3 k59_215528_1 1277672.M9QRT1_9CAUD 1.57e-17 88.6 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_1051626_1 1121943.KB900002_gene3060 3.9e-42 154.0 COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,1RMCR@1236|Gammaproteobacteria,1XJMJ@135619|Oceanospirillales 135619|Oceanospirillales P protein involved in response to NO nnrS - - ko:K07234 - - - - ko00000 - - - NnrS k59_1051626_2 1313172.YM304_24680 7.01e-12 65.5 COG2230@1|root,COG2230@2|Bacteria,2H060@201174|Actinobacteria 201174|Actinobacteria M Methyltransferase - - - - - - - - - - - - Methyltransf_31 k59_1051629_1 1229909.NSED_03100 2.08e-110 327.0 COG1060@1|root,arCOG00657@2157|Archaea,41S95@651137|Thaumarchaeota 651137|Thaumarchaeota H Radical SAM - - 2.5.1.77 ko:K11780 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_687361_1 583345.Mmol_1202 1.88e-21 95.9 COG1664@1|root,COG1664@2|Bacteria,1QUZJ@1224|Proteobacteria,2WGN3@28216|Betaproteobacteria 28216|Betaproteobacteria M Polymer-forming cytoskeletal - - - ko:K12287 - - - - ko00000,ko02044 - - - - k59_424656_1 243233.MCA3076 1.64e-57 193.0 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,1XEHX@135618|Methylococcales 135618|Methylococcales N ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux k59_372315_1 1229909.NSED_05585 5.93e-30 110.0 arCOG00516@1|root,arCOG00516@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - Putative_PNPOx,Pyridox_ox_2 k59_1312422_1 330214.NIDE0898 1.72e-42 148.0 COG0723@1|root,COG0723@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on diphenols and related substances as donors - - 1.3.5.1,1.3.5.4 ko:K00240,ko:K03886 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00151,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Rieske k59_1312422_2 330214.NIDE0897 4.65e-65 207.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - ko:K17052 - - - - ko00000,ko02000 5.A.3.8 - - Cytochrom_C,EB_dh k59_1051638_1 445685.E3SKE8_9CAUD 2.79e-58 194.0 4QHGQ@10239|Viruses,4QXXQ@35237|dsDNA viruses no RNA stage,4QQMM@28883|Caudovirales,4QK7P@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1470167_1 1172181.KB911714_gene4691 2.57e-69 226.0 COG1804@1|root,COG1804@2|Bacteria,2I8FK@201174|Actinobacteria 201174|Actinobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1103893_1 1192034.CAP_3148 3.23e-08 62.0 COG3857@1|root,COG3857@2|Bacteria,1QXU1@1224|Proteobacteria,43C6K@68525|delta/epsilon subdivisions,2X7GU@28221|Deltaproteobacteria,2Z1DQ@29|Myxococcales 28221|Deltaproteobacteria L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1 k59_895006_2 1219080.VEZ01S_58_00030 3.44e-10 58.9 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,1XV2V@135623|Vibrionales 135623|Vibrionales K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006282,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0080134,GO:0080135,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_687388_1 1229909.NSED_08945 7.6e-21 96.3 COG4257@1|root,arCOG06267@1|root,arCOG03564@2157|Archaea,arCOG06267@2157|Archaea,41S5S@651137|Thaumarchaeota 651137|Thaumarchaeota V resistance protein - - - ko:K14166 - - - - ko00000,ko02000 - - - CopC,CopD k59_687388_2 436308.Nmar_1653 2.14e-06 48.5 COG1108@1|root,arCOG01006@2157|Archaea,41SG2@651137|Thaumarchaeota 651137|Thaumarchaeota P ABC 3 transport family - - - ko:K09816 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_1364853_2 472759.Nhal_3585 6.13e-57 186.0 KOG2165@1|root,2Z911@2|Bacteria,1N8JM@1224|Proteobacteria,1RR9Z@1236|Gammaproteobacteria,1WWIT@135613|Chromatiales 135613|Chromatiales S ubiquitin protein ligase binding - - - - - - - - - - - - - k59_60716_1 469371.Tbis_2039 5.61e-24 104.0 COG0566@1|root,COG0566@2|Bacteria,2GJI6@201174|Actinobacteria,4DX6V@85010|Pseudonocardiales 201174|Actinobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family tsnR - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind k59_60716_2 1038869.AXAN01000003_gene2679 6.53e-23 97.8 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2VKAP@28216|Betaproteobacteria,1K3EK@119060|Burkholderiaceae 28216|Betaproteobacteria V beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_635292_1 331869.BAL199_27226 3.6e-54 185.0 COG0477@1|root,2Z82B@2|Bacteria,1R9GD@1224|Proteobacteria,2TTIS@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_895018_1 998674.ATTE01000001_gene280 1.25e-97 308.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1QV5I@1224|Proteobacteria,1SK44@1236|Gammaproteobacteria,463WS@72273|Thiotrichales 1236|Gammaproteobacteria E FAD dependent oxidoreductase central domain - - - - - - - - - - - - DAO,FAO_M,GCV_T,GCV_T_C k59_791867_1 247633.GP2143_07434 4.41e-57 189.0 COG1051@1|root,COG1051@2|Bacteria,1QUPQ@1224|Proteobacteria 1224|Proteobacteria F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - - - - - - - - - - NUDIX k59_791867_2 1173026.Glo7428_1338 8.05e-30 119.0 COG0438@1|root,COG0438@2|Bacteria,1G31B@1117|Cyanobacteria 1117|Cyanobacteria M Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_1573335_1 1221522.B723_30605 1.75e-111 335.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1YNX8@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria E Exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_215561_1 292415.Tbd_0070 3.21e-148 432.0 COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2VIU7@28216|Betaproteobacteria,1KSV4@119069|Hydrogenophilales 119069|Hydrogenophilales C Cytochrome D1 heme domain - - - - - - - - - - - - Cytochrom_D1,Cytochrome_CBB3 k59_687399_1 377629.TERTU_3437 7.13e-84 254.0 arCOG03638@1|root,2Z7NN@2|Bacteria,1R3Y6@1224|Proteobacteria,1RTWY@1236|Gammaproteobacteria,2PPR1@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_687399_2 298386.PBPRA2811 2.7e-99 297.0 arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,1RMI8@1236|Gammaproteobacteria,1XUA3@135623|Vibrionales 135623|Vibrionales S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_581250_1 436308.Nmar_1728 6.96e-140 396.0 COG0638@1|root,arCOG00970@2157|Archaea,41T1N@651137|Thaumarchaeota 651137|Thaumarchaeota O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation - - 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome k59_1051673_1 679937.Bcop_2301 4.97e-48 169.0 COG0189@1|root,COG0189@2|Bacteria,4NF2R@976|Bacteroidetes,2FQYA@200643|Bacteroidia,4AM5S@815|Bacteroidaceae 976|Bacteroidetes F Belongs to the D-alanine--D-alanine ligase family - - - - - - - - - - - - Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK k59_1051673_2 573370.DMR_22610 6.58e-14 71.6 COG2170@1|root,COG2170@2|Bacteria,1MY35@1224|Proteobacteria,42PBG@68525|delta/epsilon subdivisions,2WK4S@28221|Deltaproteobacteria,2M991@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM Glutamate-cysteine ligase - - - - - - - - - - - - GCS2 k59_1210023_1 471852.Tcur_1212 0.000145 46.2 COG1216@1|root,COG1887@1|root,COG1216@2|Bacteria,COG1887@2|Bacteria,2GM0T@201174|Actinobacteria,4EFIJ@85012|Streptosporangiales 201174|Actinobacteria M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase - - 2.7.8.12 ko:K09809 - - - - ko00000,ko01000 - - - Glycos_transf_2,Glyphos_transf k59_1470208_1 1158318.ATXC01000001_gene396 2.25e-81 255.0 COG1812@1|root,COG1812@2|Bacteria,2G3UM@200783|Aquificae 200783|Aquificae E PFAM S-adenosylmethionine synthetase (MAT) - - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_Synthase k59_687412_1 1089547.KB913013_gene3023 1.59e-28 113.0 COG1515@1|root,COG1515@2|Bacteria,4NI4J@976|Bacteroidetes,47KIS@768503|Cytophagia 976|Bacteroidetes L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA nfi - 3.1.21.7 ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 k59_1312457_1 395493.BegalDRAFT_3409 1.01e-12 65.1 COG2104@1|root,COG2104@2|Bacteria,1N9VX@1224|Proteobacteria 1224|Proteobacteria H PFAM thiamineS protein - - - - - - - - - - - - ThiS,Ub-Mut7C k59_1312457_2 1179778.PMM47T1_12968 2.89e-112 332.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,1RMH5@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the arginase family speB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008783,GO:0009058,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0030145,GO:0034641,GO:0042401,GO:0043167,GO:0043169,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11,3.5.3.8 ko:K01479,ko:K01480 ko00330,ko00340,ko01100,map00330,map00340,map01100 M00045,M00133 R01157,R02285 RC00024,RC00221,RC00329,RC00681 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_02730,iECB_1328.ECB_02767,iECD_1391.ECD_02767,iSbBS512_1146.SbBS512_E3370 Arginase k59_110691_1 380394.Lferr_2805 2.99e-22 97.1 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,2NCFU@225057|Acidithiobacillales 225057|Acidithiobacillales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_60741_1 930169.B5T_01084 3.11e-132 389.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1XI9W@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1051685_1 546266.NEIMUCOT_06302 5.13e-12 68.6 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,2VPGP@28216|Betaproteobacteria,2KQN6@206351|Neisseriales 206351|Neisseriales H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_1051685_2 626887.J057_18080 6.8e-15 73.6 COG2356@1|root,COG2356@2|Bacteria,1MXQM@1224|Proteobacteria,1RPX9@1236|Gammaproteobacteria,467S3@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG2356 Endonuclease I endA - 3.1.21.1 ko:K01150 - - - - ko00000,ko01000 - - - Ada_Zn_binding,Endonuclease_1 k59_946460_1 887062.HGR_07536 6.74e-15 79.3 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,4AAY8@80864|Comamonadaceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family nolG - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_528882_1 247634.GPB2148_96 3.93e-121 371.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria,1SMN0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1625984_1 998088.B565_1887 3.35e-39 147.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1Y52F@135624|Aeromonadales 135624|Aeromonadales IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1262116_2 1283284.AZUK01000001_gene2764 3.46e-24 100.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria,1Y3MF@135624|Aeromonadales 135624|Aeromonadales M secretion protein HlyD family - - - ko:K12542 - M00330 - - ko00000,ko00002,ko02000,ko02044 3.A.1.109.4,8.A.1 - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_1210032_1 260799.BAS1268 2.61e-17 87.4 2EGKK@1|root,33ACU@2|Bacteria,1VK7U@1239|Firmicutes,4ISR9@91061|Bacilli,1ZKSB@1386|Bacillus 91061|Bacilli L GIY-YIG catalytic domain - - - - - - - - - - - - GIY-YIG,NUMOD3 k59_687424_2 1123487.KB892867_gene974 1.02e-14 73.9 COG0791@1|root,COG0791@2|Bacteria,1PW5U@1224|Proteobacteria,2VV27@28216|Betaproteobacteria,2KZ83@206389|Rhodocyclales 206389|Rhodocyclales M NLP P60 protein - - - - - - - - - - - - - k59_215595_1 243233.MCA3039 9.13e-91 276.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1XGZA@135618|Methylococcales 135618|Methylococcales K LysR substrate binding domain - - - ko:K21703 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1210046_1 465817.ETA_03900 8.34e-24 104.0 COG2199@1|root,COG3706@2|Bacteria,1MX83@1224|Proteobacteria,1RMRP@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,dCache_1 k59_1417112_1 1411123.JQNH01000001_gene102 1.23e-39 143.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_635347_2 1283300.ATXB01000001_gene715 2.06e-16 73.6 COG0662@1|root,COG0662@2|Bacteria,1N7Q4@1224|Proteobacteria,1SEVR@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 k59_946470_1 686340.Metal_1717 4.81e-117 347.0 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1XE2M@135618|Methylococcales 135618|Methylococcales H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_1262137_1 861299.J421_3809 4.77e-67 221.0 COG0058@1|root,COG0058@2|Bacteria,1ZSZ3@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Carbohydrate phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_110708_1 187272.Mlg_1695 2.03e-62 218.0 COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,1RSDZ@1236|Gammaproteobacteria,1WVWP@135613|Chromatiales 135613|Chromatiales T PFAM ATP-binding region - - - - - - - - - - - - HATPase_c,HisKA k59_110708_2 1122599.AUGR01000006_gene3864 2.41e-125 374.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XIG8@135619|Oceanospirillales 135619|Oceanospirillales T Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_1210057_1 398578.Daci_2326 0.00082 45.4 COG3064@1|root,COG3264@1|root,COG3064@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria,4AGDW@80864|Comamonadaceae 28216|Betaproteobacteria M Mechanosensitive ion channel inner membrane domain 1 - - - ko:K05802,ko:K22051 - - - - ko00000,ko02000 1.A.23.1.1,1.A.23.1.2,1.A.23.1.3 - - MS_channel,MscS_TM,MscS_porin k59_1210059_1 626887.J057_08111 5.04e-66 214.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,465H4@72275|Alteromonadaceae 1236|Gammaproteobacteria LU Rossmann fold nucleotide-binding protein involved in DNA uptake smf - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_3458_1 1242864.D187_001236 1.15e-81 257.0 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,42P9W@68525|delta/epsilon subdivisions,2WK54@28221|Deltaproteobacteria,2YUU0@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_3458_2 350688.Clos_0574 2.4e-63 205.0 COG1660@1|root,COG1660@2|Bacteria,1TPS4@1239|Firmicutes,248KQ@186801|Clostridia,36DI8@31979|Clostridiaceae 186801|Clostridia S Displays ATPase and GTPase activities yvcJ - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_379996_1 1229909.NSED_08870 1.24e-101 318.0 COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,41SAH@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_117778_1 316067.Geob_1707 2.17e-105 312.0 COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,42MZB@68525|delta/epsilon subdivisions,2WKV4@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PFAM Integral membrane protein TerC - - - - - - - - - - - - TerC k59_953214_1 436308.Nmar_1105 2.19e-98 304.0 COG0556@1|root,arCOG04748@2157|Archaea,41T0H@651137|Thaumarchaeota 651137|Thaumarchaeota L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1479064_1 203122.Sde_0717 4e-46 168.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,46478@72275|Alteromonadaceae 1236|Gammaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_1058400_1 323261.Noc_1254 3.95e-128 391.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales 135613|Chromatiales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_485501_2 444861.E3SPJ6_9CAUD 1.85e-09 64.7 4QCY4@10239|Viruses,4QVJ1@35237|dsDNA viruses no RNA stage,4QTAC@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_380028_1 1238182.C882_4198 2.21e-105 322.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2U0QC@28211|Alphaproteobacteria,2JQ41@204441|Rhodospirillales 204441|Rhodospirillales C Fumarate reductase flavoprotein C-term - - - - - - - - - - - - FAD_binding_2,Succ_DH_flav_C k59_431131_1 1134413.ANNK01000127_gene2493 8.69e-18 83.6 COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4HAWZ@91061|Bacilli,1ZCGC@1386|Bacillus 91061|Bacilli I acyl-CoA dehydrogenase yngJ - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_431131_3 338963.Pcar_1228 2.68e-159 458.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,43SUZ@69541|Desulfuromonadales 28221|Deltaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt-1 - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_431131_4 203120.LEUM_A11 2.67e-12 64.3 COG0394@1|root,COG0394@2|Bacteria,1V3JW@1239|Firmicutes,4HH49@91061|Bacilli,4AXT4@81850|Leuconostocaceae 91061|Bacilli T Belongs to the low molecular weight phosphotyrosine protein phosphatase family arsC GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008794,GO:0016491,GO:0030611,GO:0030613,GO:0030614,GO:0042221,GO:0046685,GO:0050896,GO:0055114 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_69696_1 436308.Nmar_1755 7.75e-19 82.4 COG0592@1|root,arCOG00488@2157|Archaea,41S6E@651137|Thaumarchaeota 651137|Thaumarchaeota L Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication pcn - - ko:K04802 ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166 M00295 - - ko00000,ko00001,ko00002,ko03032,ko03400 - - - PCNA_C,PCNA_N k59_69696_2 1229909.NSED_09340 2.01e-116 347.0 COG0527@1|root,arCOG00861@2157|Archaea,41SFA@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the aspartokinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT_7 k59_744559_1 1110502.TMO_2680 4.93e-07 56.6 COG1807@1|root,COG1807@2|Bacteria,1Q5NC@1224|Proteobacteria,2VBZI@28211|Alphaproteobacteria,2JXF3@204441|Rhodospirillales 204441|Rhodospirillales M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - - k59_1005606_1 1283300.ATXB01000002_gene2702 9.9e-143 435.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1110681_1 95619.PM1_0200160 6.7e-74 234.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:1901360,GO:1990817 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_380047_1 396588.Tgr7_2622 1.4e-109 335.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales 135613|Chromatiales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_222570_1 909663.KI867150_gene1132 7.77e-35 132.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42NHU@68525|delta/epsilon subdivisions,2WIZ1@28221|Deltaproteobacteria,2MRAJ@213462|Syntrophobacterales 28221|Deltaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.99.32 ko:K16173 ko00362,ko01120,map00362,map01120 - R05579 RC00052 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1271097_1 1197906.CAJQ02000063_gene4220 3.59e-31 115.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,3JZ81@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Evidence Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - HTH_21,rve,rve_3 k59_274803_1 997346.HMPREF9374_1221 0.000667 47.0 COG0662@1|root,COG1396@1|root,COG0662@2|Bacteria,COG1396@2|Bacteria,1V3D7@1239|Firmicutes,4HG0Z@91061|Bacilli,27CXV@186824|Thermoactinomycetaceae 91061|Bacilli K AraC-like ligand binding domain - - - - - - - - - - - - Cupin_2,HTH_3 k59_1161597_1 439235.Dalk_3373 6.8e-71 237.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42N1H@68525|delta/epsilon subdivisions,2WJ0R@28221|Deltaproteobacteria,2MHVX@213118|Desulfobacterales 28221|Deltaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_535659_1 1173026.Glo7428_2342 8.29e-30 115.0 COG0226@1|root,COG0226@2|Bacteria,1FZZ0@1117|Cyanobacteria 1117|Cyanobacteria P TIGRFAM phosphate binding protein sphX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like,PBP_like_2 k59_380065_1 713587.THITH_02145 3.69e-88 269.0 COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,1RY8Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria P DNA binding domain - - - - - - - - - - - - HTH_17,PBP_like k59_901739_1 76114.ebA723 2.03e-33 123.0 COG1028@1|root,COG1028@2|Bacteria,1RCD5@1224|Proteobacteria,2W04R@28216|Betaproteobacteria,2KXRA@206389|Rhodocyclales 206389|Rhodocyclales IQ KR domain - - - ko:K07535 ko00362,ko01120,ko01220,map00362,map01120,map01220 M00540 R05582 RC00154 ko00000,ko00001,ko00002,ko01000 - - - adh_short_C2 k59_1318252_1 397278.JOJN01000005_gene840 6.58e-62 201.0 COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria,4DPUY@85009|Propionibacteriales 201174|Actinobacteria J FtsJ-like methyltransferase tlyA GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k59_1318252_2 123899.JPQP01000018_gene270 7.45e-17 80.5 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,3T1E7@506|Alcaligenaceae 28216|Betaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_431165_1 1131266.ARWQ01000005_gene839 5.09e-23 94.4 COG2102@1|root,arCOG00035@2157|Archaea,41SHD@651137|Thaumarchaeota 651137|Thaumarchaeota S Diphthamide synthase - - 6.3.1.14 ko:K06927 - - R03613 RC00358 ko00000,ko01000,ko03012 - - - Diphthami_syn_2 k59_431165_2 1229909.NSED_02675 2.69e-52 176.0 COG0541@1|root,arCOG01228@2157|Archaea,41SDP@651137|Thaumarchaeota 651137|Thaumarchaeota U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY srp54 - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_1425517_1 365046.Rta_14960 2.18e-47 168.0 28HC9@1|root,2Z7P5@2|Bacteria,1R4BH@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_380072_1 446470.Snas_3744 2.36e-07 55.8 COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,4EYIN@85014|Glycomycetales 201174|Actinobacteria I CDP-alcohol phosphatidyltransferase pgsA2 GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_1161605_1 595460.RRSWK_05585 1.46e-91 283.0 COG2871@1|root,COG2871@2|Bacteria,2IXJE@203682|Planctomycetes 203682|Planctomycetes C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway nqrF - 1.6.5.8 ko:K00351 - - - - ko00000,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_222593_1 1122164.JHWF01000008_gene1242 6.67e-62 210.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1JD7E@118969|Legionellales 118969|Legionellales T Elongation factor G C-terminus typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_801449_1 1089550.ATTH01000001_gene1570 8.27e-20 92.8 COG1181@1|root,COG1181@2|Bacteria,4PEAY@976|Bacteroidetes,1FIPX@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C k59_1425530_1 330214.NIDE0870 4.57e-107 320.0 COG0821@1|root,COG0821@2|Bacteria,3J0EA@40117|Nitrospirae 40117|Nitrospirae I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_117874_1 56780.SYN_02788 3.29e-08 55.5 COG1032@1|root,COG1032@2|Bacteria,1P9J0@1224|Proteobacteria,42MWG@68525|delta/epsilon subdivisions,2WIV5@28221|Deltaproteobacteria,2MQYP@213462|Syntrophobacterales 28221|Deltaproteobacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_117874_2 926550.CLDAP_06280 4.09e-20 97.1 COG2141@1|root,COG3255@1|root,COG2141@2|Bacteria,COG3255@2|Bacteria,2G878@200795|Chloroflexi 200795|Chloroflexi C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_327573_1 1121889.AUDM01000008_gene844 3e-11 62.0 COG1443@1|root,COG1443@2|Bacteria,4NFJV@976|Bacteroidetes,1HXIQ@117743|Flavobacteriia,2NTVJ@237|Flavobacterium 976|Bacteroidetes I Isopentenyl-diphosphate delta-isomerase idi - 5.3.3.2 ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01123 RC00455 ko00000,ko00001,ko00002,ko01000 - - - NUDIX k59_380090_2 269799.Gmet_0868 4.2e-33 117.0 COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,431I1@68525|delta/epsilon subdivisions,2WWQT@28221|Deltaproteobacteria,43VG1@69541|Desulfuromonadales 28221|Deltaproteobacteria L bacterial (prokaryotic) histone like domain ihfB-2 - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_1580109_1 298655.KI912266_gene3725 3.7e-20 94.7 COG2124@1|root,COG2124@2|Bacteria,2GJ3T@201174|Actinobacteria 201174|Actinobacteria Q cytochrome P450 - - - - - - - - - - - - p450 k59_1580109_2 1440774.Y900_021225 7.88e-19 89.0 COG2124@1|root,COG2124@2|Bacteria,2GJ3T@201174|Actinobacteria,23402@1762|Mycobacteriaceae 201174|Actinobacteria Q cytochrome p450 - - - - - - - - - - - - p450 k59_1425540_1 760154.Sulba_0491 1.43e-50 173.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,42MQU@68525|delta/epsilon subdivisions,2YMC7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q TRAP transporter, DctM subunit - - - - - - - - - - - - DctM,DctQ k59_1425540_2 1121918.ARWE01000001_gene3052 1.39e-24 96.7 COG4665@1|root,COG4665@2|Bacteria,1REH8@1224|Proteobacteria,43B1K@68525|delta/epsilon subdivisions 1224|Proteobacteria Q COGs COG4665 TRAP-type mannitol chloroaromatic compound transport system small permease component - - - - - - - - - - - - DctQ k59_69766_1 1042877.GQS_01330 3.24e-19 86.3 COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota,242X5@183968|Thermococci 183968|Thermococci V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_1580113_1 1167006.UWK_00007 6.61e-52 177.0 COG1916@1|root,COG1916@2|Bacteria,1MWJ0@1224|Proteobacteria,42P2H@68525|delta/epsilon subdivisions,2WJQM@28221|Deltaproteobacteria,2MI76@213118|Desulfobacterales 28221|Deltaproteobacteria S TIGRFAM TraB family protein - - - - - - - - - - - - TraB k59_694506_1 436308.Nmar_0062 4.6e-59 194.0 COG0463@1|root,arCOG00894@2157|Archaea,41SAS@651137|Thaumarchaeota 651137|Thaumarchaeota M glycosyl transferase family 2 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2,GtrA k59_644414_1 626418.bglu_1g07840 6.47e-54 177.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2VII1@28216|Betaproteobacteria,1K2HH@119060|Burkholderiaceae 28216|Betaproteobacteria L similarity to GP 17427840 - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_328538_1 1101189.AQUO01000001_gene1664 1.3e-21 96.7 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TSF3@28211|Alphaproteobacteria,2PVNJ@265|Paracoccus 28211|Alphaproteobacteria EP Binding-protein-dependent transport system inner membrane component appB - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_536539_1 879243.Poras_1410 9.02e-09 54.3 COG0509@1|root,COG0509@2|Bacteria,4NQ35@976|Bacteroidetes,2FT3J@200643|Bacteroidia,22Y67@171551|Porphyromonadaceae 976|Bacteroidetes E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H k59_536539_2 941639.BCO26_1683 3.4e-63 211.0 COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,4HA7P@91061|Bacilli,1ZB0H@1386|Bacillus 91061|Bacilli E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_223492_1 1168065.DOK_07194 1.51e-81 258.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1J7YI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - Sulfatase k59_486783_1 1110502.TMO_2475 5.21e-25 96.7 COG2212@1|root,COG2212@2|Bacteria,1N6VV@1224|Proteobacteria,2UHB7@28211|Alphaproteobacteria,2JU0Y@204441|Rhodospirillales 204441|Rhodospirillales P Multiple resistance and pH regulation protein F (MrpF / PhaF) - - - ko:K05570 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MrpF_PhaF k59_486783_2 523850.TON_0498 1.44e-21 90.5 COG1863@1|root,arCOG03099@2157|Archaea,2XTHH@28890|Euryarchaeota,2430X@183968|Thermococci 183968|Thermococci P Na+/H+ ion antiporter subunit - - - ko:K05569 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MNHE k59_381290_1 1229909.NSED_08720 1.98e-19 82.0 arCOG10596@1|root,arCOG10596@2157|Archaea,41T8F@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_381290_2 436308.Nmar_1608 6.95e-66 212.0 COG1012@1|root,arCOG01252@2157|Archaea,41T0F@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Aldehyde dehydrogenase - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135,ko:K18601 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_432262_1 330214.NIDE1091 4.79e-135 389.0 COG0167@1|root,COG0167@2|Bacteria,3J145@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the conversion of dihydroorotate to orotate pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.98.1 ko:K00226,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01867,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_381299_1 762376.AXYL_03781 2.54e-17 80.9 29ISC@1|root,2Z7VE@2|Bacteria,1MWUK@1224|Proteobacteria,2VP02@28216|Betaproteobacteria,3T6V8@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_381299_2 1157708.KB907478_gene1208 2.54e-48 164.0 COG2175@1|root,COG2175@2|Bacteria,1P6UZ@1224|Proteobacteria,2WGAC@28216|Betaproteobacteria 28216|Betaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family - - 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_1006603_1 522306.CAP2UW1_4091 1.25e-13 75.9 COG3083@1|root,COG3083@2|Bacteria,1MX6X@1224|Proteobacteria,2WHVT@28216|Betaproteobacteria,1KR1K@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF229) - - - ko:K07014 - - - - ko00000 - - - DUF3413,Sulfatase k59_1006603_2 935845.JADQ01000035_gene2190 2.92e-10 62.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HA52@91061|Bacilli,26RDT@186822|Paenibacillaceae 91061|Bacilli T Histidine kinase vicK - 2.7.13.3 ko:K07652 ko02020,map02020 M00459 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_9 k59_802684_1 7370.XP_005189592.1 4.05e-08 55.5 COG0524@1|root,KOG2854@2759|Eukaryota,3A218@33154|Opisthokonta,3BRAI@33208|Metazoa,3D7G3@33213|Bilateria,41Z6A@6656|Arthropoda,3SR70@50557|Insecta,453FS@7147|Diptera 33208|Metazoa G Phosphotransferase activity, alcohol group as acceptor - GO:0003674,GO:0003824,GO:0004001,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006166,GO:0006167,GO:0006169,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0043174,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.20 ko:K00856 ko00230,ko01100,map00230,map01100 - R00185 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_802684_2 566466.NOR53_579 2.08e-43 154.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,1RPPD@1236|Gammaproteobacteria,1J8J6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Peptidase family M28 - - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1372637_1 1255043.TVNIR_3225 9.84e-135 399.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1WWDG@135613|Chromatiales 135613|Chromatiales E TIGRFAM Acetolactate synthase, large subunit, biosynthetic - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_486818_1 596151.DesfrDRAFT_2056 0.000315 42.7 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,42MV7@68525|delta/epsilon subdivisions,2WJTU@28221|Deltaproteobacteria,2M8RD@213115|Desulfovibrionales 28221|Deltaproteobacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_1634461_1 396588.Tgr7_0830 4.56e-89 268.0 COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,1RNDY@1236|Gammaproteobacteria,1WW3H@135613|Chromatiales 135613|Chromatiales S Converts GTP to 7,8-dihydroneopterin triphosphate folE2 - 3.5.4.16 ko:K09007 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GCHY-1 k59_1059524_1 1380394.JADL01000007_gene4625 9.41e-73 232.0 COG0438@1|root,COG0438@2|Bacteria,1MY5T@1224|Proteobacteria,2TSZW@28211|Alphaproteobacteria,2JSZJ@204441|Rhodospirillales 204441|Rhodospirillales M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1 k59_645631_2 228410.NE2030 1.03e-36 135.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2VIP2@28216|Betaproteobacteria,372V3@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_334593_1 2340.JV46_12820 6.54e-63 201.0 COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,1S74N@1236|Gammaproteobacteria,1J6I7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0019720,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061603,GO:0070568,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902757,GO:1902758 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_2604,iEcHS_1320.EcHS_A4080,iEcolC_1368.EcolC_4158,iLF82_1304.LF82_1370,iNRG857_1313.NRG857_19230,iSBO_1134.SBO_3869,iSbBS512_1146.SbBS512_E4329,iUMNK88_1353.UMNK88_4686,ic_1306.c4801 NTP_transf_3 k59_334593_2 754331.AEME01000001_gene997 3.46e-41 141.0 COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,1S72P@1236|Gammaproteobacteria,3XNU6@561|Escherichia 1236|Gammaproteobacteria H GTP-binding protein that is not required for the biosynthesis of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor, and not necessary for the formation of active molybdoenzymes using this form of molybdenum cofactor. May act as an adapter protein to achieve the efficient biosynthesis and utilization of MGD. Displays a weak intrinsic GTPase activity. Is also able to bind the nucleotides ATP, TTP and GDP, but with lower affinity than GTP mobB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.7.7.77 ko:K03753,ko:K13818 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - iB21_1397.B21_03691,iBWG_1329.BWG_3527,iECBD_1354.ECBD_4174,iECDH1ME8569_1439.ECDH1ME8569_3728,iEcDH1_1363.EcDH1_4130,iJO1366.b3856,iSbBS512_1146.SbBS512_E4328,iY75_1357.Y75_RS17805 MobB k59_126396_1 1298858.AUEL01000005_gene1113 8.98e-74 240.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,43IM3@69277|Phyllobacteriaceae 28211|Alphaproteobacteria IQ AMP-binding enzyme C-terminal domain fadD GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006635,GO:0006637,GO:0006644,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009898,GO:0009987,GO:0015645,GO:0016020,GO:0016042,GO:0016054,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019395,GO:0019637,GO:0019693,GO:0019752,GO:0030258,GO:0031406,GO:0032787,GO:0033293,GO:0033865,GO:0033875,GO:0034032,GO:0034440,GO:0034641,GO:0035383,GO:0036041,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046395,GO:0046483,GO:0050896,GO:0051186,GO:0055086,GO:0055114,GO:0070538,GO:0071704,GO:0071944,GO:0072329,GO:0072521,GO:0090407,GO:0098552,GO:0098562,GO:1901135,GO:1901360,GO:1901564,GO:1901575,GO:1901576 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1434693_2 1299327.I546_2827 3.82e-11 63.2 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,234H1@1762|Mycobacteriaceae 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_494994_1 395495.Lcho_3893 6.15e-77 258.0 COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,2VZQA@28216|Betaproteobacteria,1KNDH@119065|unclassified Burkholderiales 28216|Betaproteobacteria Q Multicopper oxidase - - 1.16.3.3 ko:K22349 - - - - ko00000,ko01000 - - - - k59_1378330_2 485913.Krac_11540 1.86e-11 65.5 COG3119@1|root,COG3119@2|Bacteria,2G7YZ@200795|Chloroflexi 200795|Chloroflexi P PFAM Sulfatase - - - - - - - - - - - - Sulfatase k59_542397_1 68223.JNZY01000010_gene1752 1.44e-41 155.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria 201174|Actinobacteria Q cytochrome p450 - - - - - - - - - - - - p450 k59_1488425_1 765914.ThisiDRAFT_2778 7.59e-49 163.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,1RMXS@1236|Gammaproteobacteria,1WW0T@135613|Chromatiales 135613|Chromatiales E PFAM Methylenetetrahydrofolate reductase - - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_1488425_2 631362.Thi970DRAFT_04202 6.95e-40 136.0 COG0316@1|root,COG0316@2|Bacteria,1RFIX@1224|Proteobacteria,1S3SB@1236|Gammaproteobacteria,1WYBH@135613|Chromatiales 135613|Chromatiales S Belongs to the HesB IscA family - - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_388984_1 316055.RPE_3219 1.74e-73 233.0 COG0183@1|root,COG0183@2|Bacteria,1MXYM@1224|Proteobacteria,2TUBT@28211|Alphaproteobacteria,3K2FJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Thiolase, C-terminal domain - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_1528857_1 404589.Anae109_3703 3.91e-20 94.4 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,42NJ0@68525|delta/epsilon subdivisions,2WJ7A@28221|Deltaproteobacteria,2YTYT@29|Myxococcales 28221|Deltaproteobacteria M Peptidase family M50 rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_810900_1 1049564.TevJSym_ay00370 7.45e-135 412.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1J4SF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cusA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_9742_1 395493.BegalDRAFT_0308 7.45e-127 372.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,1T1GA@1236|Gammaproteobacteria,4602W@72273|Thiotrichales 72273|Thiotrichales E Cys/Met metabolism PLP-dependent enzyme - - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_1280860_1 886293.Sinac_4411 3.76e-51 176.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glycos_transf_1 k59_856651_1 1245471.PCA10_55750 5.65e-47 167.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1YHUX@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria V MacB-like periplasmic core domain VP1997 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1117682_1 1123400.KB904791_gene67 2.76e-23 99.4 COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,460WJ@72273|Thiotrichales 72273|Thiotrichales L TIGRFAM DNA polymerase III, delta - - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C k59_1323457_1 269799.Gmet_2580 1.36e-74 250.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_282200_1 756067.MicvaDRAFT_4171 9.8e-18 87.0 COG3021@1|root,COG3021@2|Bacteria,1G1V5@1117|Cyanobacteria,1HAVR@1150|Oscillatoriales 1117|Cyanobacteria S Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_1012910_1 1123368.AUIS01000017_gene2594 5.83e-55 181.0 COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,2NC2P@225057|Acidithiobacillales 225057|Acidithiobacillales I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - - IspD k59_1225275_1 1000565.METUNv1_03025 1.5e-80 251.0 28HGQ@1|root,2Z7SH@2|Bacteria,1R6PH@1224|Proteobacteria,2VK2P@28216|Betaproteobacteria,2KVI7@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_334631_1 436308.Nmar_0795 1.01e-32 115.0 COG0096@1|root,arCOG04091@2157|Archaea,41SMM@651137|Thaumarchaeota 651137|Thaumarchaeota J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rps8 - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_334631_2 436308.Nmar_0796 4.36e-38 127.0 COG0199@1|root,arCOG00782@2157|Archaea,41SW8@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein S14 rps14 - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_334631_3 436308.Nmar_0797 9.09e-34 120.0 COG0094@1|root,arCOG04092@2157|Archaea,41SJP@651137|Thaumarchaeota 651137|Thaumarchaeota J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rpl5 - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_909003_1 1116472.MGMO_88c00060 3.04e-96 288.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1XDXQ@135618|Methylococcales 135618|Methylococcales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_1434754_1 331869.BAL199_25847 1.07e-21 92.8 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2TRMT@28211|Alphaproteobacteria,4BQ1Q@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh k59_1434754_2 555779.Dthio_PD2463 1.23e-29 109.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,42SVI@68525|delta/epsilon subdivisions,2WP7T@28221|Deltaproteobacteria,2MBIE@213115|Desulfovibrionales 28221|Deltaproteobacteria J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_1167087_1 105559.Nwat_0624 3.11e-131 392.0 COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,1RNFJ@1236|Gammaproteobacteria,1WWXB@135613|Chromatiales 135613|Chromatiales T PFAM PrkA AAA - - - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_9754_2 445686.E3SLF6_9CAUD 5.63e-31 112.0 4QAUK@10239|Viruses,4QWEQ@35237|dsDNA viruses no RNA stage,4QQ1Z@28883|Caudovirales,4QIGD@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_174163_1 13035.Dacsa_2616 1.76e-64 206.0 COG0036@1|root,COG0036@2|Bacteria,1G0MH@1117|Cyanobacteria 1117|Cyanobacteria G Belongs to the ribulose-phosphate 3-epimerase family rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_959996_2 396595.TK90_0560 6.9e-22 87.8 COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,1SCPF@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the acylphosphatase family acyP GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036 Acylphosphatase k59_1280911_1 502025.Hoch_2179 2.01e-68 224.0 COG3509@1|root,COG3509@2|Bacteria,1MXUI@1224|Proteobacteria,430Q8@68525|delta/epsilon subdivisions,2WVYQ@28221|Deltaproteobacteria,2YU06@29|Myxococcales 28221|Deltaproteobacteria Q Esterase PHB depolymerase - - - - - - - - - - - - Esterase_phd k59_1641514_2 287.DR97_4131 1.24e-36 125.0 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,1S8RT@1236|Gammaproteobacteria,1YGM8@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_1641514_3 1033802.SSPSH_002041 0.000109 43.9 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria 1236|Gammaproteobacteria J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_653850_1 1283300.ATXB01000001_gene80 8.02e-12 70.1 COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,1RZIZ@1236|Gammaproteobacteria,1XF4P@135618|Methylococcales 135618|Methylococcales NU Type IV Pilus-assembly protein W - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_229428_1 1380346.JNIH01000008_gene1467 8.76e-180 507.0 COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria 201174|Actinobacteria G Belongs to the HpcH HpaI aldolase family - - 4.1.3.24,4.1.3.25 ko:K08691 ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,map00630,map00660,map00680,map00720,map01120,map01200 M00346,M00373,M00376 R00237,R00473,R00934 RC00307,RC00308,RC00311,RC00407,RC00502,RC01205 ko00000,ko00001,ko00002,ko01000 - - - HpcH_HpaI k59_126466_1 1049564.TevJSym_bb00030 1.97e-22 100.0 COG1013@1|root,COG1013@2|Bacteria,1R28U@1224|Proteobacteria 1224|Proteobacteria C 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - - - - - - - - - - TPP_enzyme_C k59_1379214_1 870187.Thini_3645 3.23e-99 301.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,4601D@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_440284_1 1335757.SPICUR_07590 8.88e-99 313.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_702445_1 330214.NIDE0278 5.19e-35 131.0 COG2812@1|root,COG2812@2|Bacteria,3J0DD@40117|Nitrospirae 40117|Nitrospirae L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 k59_230253_1 1298880.AUEV01000001_gene5838 1.62e-09 62.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - - - - - - - - - - - Methyltransf_23 k59_812052_1 1203606.HMPREF1526_01592 5.05e-39 142.0 COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,36EEP@31979|Clostridiaceae 186801|Clostridia HP ABC transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_812052_2 349520.PPE_01286 6.49e-13 72.0 COG0614@1|root,COG0614@2|Bacteria,1UNE3@1239|Firmicutes,4H9ZX@91061|Bacilli,26QWQ@186822|Paenibacillaceae 91061|Bacilli P ABC-type Fe3 -hydroxamate transport system, periplasmic component yvrC - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_335475_2 869210.Marky_1921 1.24e-23 101.0 COG0517@1|root,COG5485@1|root,COG0517@2|Bacteria,COG5485@2|Bacteria,1WK3F@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_1013773_1 1502851.FG93_00182 2.36e-76 266.0 COG0642@1|root,COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1 k59_1379231_2 1005048.CFU_0710 4.32e-50 170.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2VH0J@28216|Betaproteobacteria,473CR@75682|Oxalobacteraceae 28216|Betaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_1435868_1 1131266.ARWQ01000002_gene599 1.68e-46 155.0 COG1259@1|root,arCOG01759@2157|Archaea,41SQI@651137|Thaumarchaeota 651137|Thaumarchaeota S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase k59_1066641_1 1415754.JQMK01000002_gene2713 7.9e-20 90.5 COG0515@1|root,COG0631@1|root,COG0515@2|Bacteria,COG0631@2|Bacteria,1MV1P@1224|Proteobacteria,1RNQN@1236|Gammaproteobacteria,464NH@72275|Alteromonadaceae 1236|Gammaproteobacteria T Serine threonine protein - - 3.1.3.16 ko:K01090 - - - - ko00000,ko01000 - - - PP2C_2,Pkinase k59_1066641_2 1049564.TevJSym_aa00460 4.09e-67 218.0 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,1RP5H@1236|Gammaproteobacteria,1J8E0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG2223 Nitrate nitrite transporter - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_440308_1 1041146.ATZB01000034_gene560 7.26e-12 62.0 COG1553@1|root,COG1553@2|Bacteria,1RDFR@1224|Proteobacteria,2U9F0@28211|Alphaproteobacteria,4BJRG@82115|Rhizobiaceae 28211|Alphaproteobacteria P DsrE/DsrF-like family - - - ko:K06039 - - - - ko00000 - - - DrsE k59_440308_2 1434325.AZQN01000011_gene3768 1.63e-08 62.0 COG0500@1|root,COG2226@2|Bacteria,4NM1I@976|Bacteroidetes,47JZX@768503|Cytophagia 976|Bacteroidetes Q Mycolic acid cyclopropane synthetase - - - - - - - - - - - - Methyltransf_11,Ubie_methyltran k59_596054_1 65393.PCC7424_2021 5.26e-29 121.0 COG0642@1|root,COG2202@1|root,COG2203@1|root,COG3437@1|root,COG3829@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,COG3829@2|Bacteria,1G09B@1117|Cyanobacteria,3KJDH@43988|Cyanothece 1117|Cyanobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9 k59_909890_1 1348657.M622_15050 2.04e-23 95.5 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VH7N@28216|Betaproteobacteria,2KUPT@206389|Rhodocyclales 206389|Rhodocyclales L exodeoxyribonuclease III - - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_909890_2 1123401.JHYQ01000025_gene3306 7.1e-51 170.0 COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1RNDT@1236|Gammaproteobacteria,461C6@72273|Thiotrichales 72273|Thiotrichales GM NAD dependent epimerase/dehydratase family - - - - - - - - - - - - Epimerase,NAD_binding_10 k59_857530_1 1232437.KL662031_gene2546 1.85e-65 223.0 COG0574@1|root,COG0574@2|Bacteria,1P35R@1224|Proteobacteria,42UE9@68525|delta/epsilon subdivisions,2WR5R@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - - - - - - - - - - PPDK_N k59_1588322_1 903818.KI912268_gene3074 3.65e-78 260.0 COG1009@1|root,COG1009@2|Bacteria,3Y2VS@57723|Acidobacteria 57723|Acidobacteria CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_283100_1 436308.Nmar_1690 2.44e-203 570.0 COG1156@1|root,arCOG00865@2157|Archaea,41SPY@651137|Thaumarchaeota 651137|Thaumarchaeota C Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit atpB - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N k59_1118559_1 472759.Nhal_0667 1.36e-126 378.0 COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,1RNFJ@1236|Gammaproteobacteria,1WWXB@135613|Chromatiales 135613|Chromatiales T PFAM PrkA AAA - - - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_1529588_1 886293.Sinac_6545 1.06e-38 147.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,2IYXB@203682|Planctomycetes 203682|Planctomycetes O O-linked N-acetylglucosamine transferase SPINDLY family - - - - - - - - - - - - Glyco_transf_41,TPR_16,TPR_2,TPR_6,TPR_8 k59_283120_1 998674.ATTE01000001_gene2894 1.36e-48 166.0 COG0687@1|root,COG0687@2|Bacteria,1MU0I@1224|Proteobacteria,1RMY4@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Spermidine putrescine-binding periplasmic protein - - - ko:K02055 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - SBP_bac_8 k59_174845_1 1304866.K413DRAFT_3347 1.15e-15 82.0 COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia,36EHU@31979|Clostridiaceae 186801|Clostridia E Family 5 oppA - - ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 k59_1489666_1 1206741.BAFX01000005_gene5831 2.86e-40 147.0 COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,4FWCC@85025|Nocardiaceae 201174|Actinobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1282072_1 439235.Dalk_4303 5.1e-26 102.0 COG0457@1|root,COG0457@2|Bacteria,1R438@1224|Proteobacteria,42PQ9@68525|delta/epsilon subdivisions,2WJ0C@28221|Deltaproteobacteria,2MIBG@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Tetratricopeptide - - - - - - - - - - - - TPR_1,TPR_10,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_1282072_2 933262.AXAM01000001_gene353 1.23e-58 191.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,42M0X@68525|delta/epsilon subdivisions,2WK4D@28221|Deltaproteobacteria,2MHXX@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_1118584_1 324602.Caur_1718 4.23e-32 127.0 COG0160@1|root,COG0160@2|Bacteria,2G5KN@200795|Chloroflexi,374UQ@32061|Chloroflexia 32061|Chloroflexia E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.19 ko:K00823 ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_596089_1 1120925.F941_02436 1.21e-24 105.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,1RQ50@1236|Gammaproteobacteria,3NK8N@468|Moraxellaceae 1236|Gammaproteobacteria E FAD dependent oxidoreductase thiO GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0036094,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043436,GO:0043799,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0072527,GO:0072528,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.4.3.19 ko:K03153 ko00730,ko01100,map00730,map01100 - R07463 RC01788 ko00000,ko00001,ko01000 - - - DAO k59_752593_1 999541.bgla_2g25440 1.94e-44 147.0 COG0251@1|root,COG0251@2|Bacteria,1RAKQ@1224|Proteobacteria,2VQPC@28216|Betaproteobacteria,1K21Z@119060|Burkholderiaceae 28216|Betaproteobacteria J endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_752593_2 84531.JMTZ01000002_gene779 4.36e-61 191.0 COG3791@1|root,COG3791@2|Bacteria,1N6S5@1224|Proteobacteria,1SCC4@1236|Gammaproteobacteria,1X8DT@135614|Xanthomonadales 135614|Xanthomonadales S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_230325_1 56110.Oscil6304_4859 5.27e-43 150.0 COG4221@1|root,COG4221@2|Bacteria,1G5GY@1117|Cyanobacteria,1HDUT@1150|Oscillatoriales 1117|Cyanobacteria S Domain of unknown function (DUF4336) - - - - - - - - - - - - DUF4336 k59_230325_2 575540.Isop_3017 9.5e-06 52.8 COG0845@1|root,COG0845@2|Bacteria,2IZ3N@203682|Planctomycetes 203682|Planctomycetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_1013850_1 95619.PM1_0226505 3.08e-105 318.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor bioA GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUTI89_1310.UTI89_C0772,iZ_1308.Z0993 Aminotran_3 k59_666541_1 187272.Mlg_2774 3.58e-123 373.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales 135613|Chromatiales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_1501028_1 313606.M23134_02374 1.98e-92 284.0 COG4948@1|root,COG4948@2|Bacteria,4NG8N@976|Bacteroidetes,47K7T@768503|Cytophagia 976|Bacteroidetes M mandelate racemase muconate lactonizing - - 4.2.1.113,5.1.1.20,5.1.1.3 ko:K01776,ko:K02549,ko:K19802 ko00130,ko00471,ko01100,ko01110,map00130,map00471,map01100,map01110 M00116 R00260,R04031,R10938 RC00302,RC01053,RC03309 ko00000,ko00001,ko00002,ko01000,ko01011 - - - MR_MLE_C,MR_MLE_N k59_345033_1 161156.JQKW01000008_gene462 2.13e-24 100.0 COG1059@1|root,COG1059@2|Bacteria 2|Bacteria L Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) ogg - 4.2.99.18 ko:K03653 - - - - ko00000,ko01000 - - - - k59_345033_2 649747.HMPREF0083_01209 6.2e-66 214.0 COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,4HAFB@91061|Bacilli,26R27@186822|Paenibacillaceae 91061|Bacilli J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_137979_1 565045.NOR51B_2319 2.37e-90 288.0 COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,1RNMS@1236|Gammaproteobacteria,1J9NH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1175185_1 1112274.KI911560_gene2429 7.66e-68 216.0 COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,2VI5F@28216|Betaproteobacteria,2KMFN@206350|Nitrosomonadales 206350|Nitrosomonadales M Putative methyltransferase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_345045_1 1232683.ADIMK_0681 6.3e-93 285.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,4641I@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - Glutaredoxin,PALP k59_551664_1 1589733.A0A0C5AAW8_9CAUD 7.8e-15 85.9 4QBUC@10239|Viruses,4QQGQ@28883|Caudovirales,4QHY3@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_865791_1 639282.DEFDS_0037 8.18e-63 205.0 COG2805@1|root,COG2805@2|Bacteria,2GEUC@200930|Deferribacteres 200930|Deferribacteres NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_396955_1 596328.HMPREF0578_1943 1.44e-52 188.0 COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,4D3UH@85005|Actinomycetales 201174|Actinobacteria L DNA helicase pcrA GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_666576_1 1075090.GOAMR_63_00390 3.68e-13 68.6 COG1066@1|root,COG1066@2|Bacteria,2GMQ0@201174|Actinobacteria,4GBGR@85026|Gordoniaceae 201174|Actinobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_666576_2 335543.Sfum_2531 1.17e-25 107.0 COG1641@1|root,COG1641@2|Bacteria,1MUKU@1224|Proteobacteria,42MHQ@68525|delta/epsilon subdivisions,2WJAC@28221|Deltaproteobacteria,2MRAV@213462|Syntrophobacterales 28221|Deltaproteobacteria S Belongs to the LarC family - - 4.99.1.12 ko:K09121 - - - - ko00000,ko01000 - - - DUF111 k59_507681_1 1122599.AUGR01000014_gene628 5.84e-57 185.0 COG0730@1|root,COG0730@2|Bacteria,1MWAN@1224|Proteobacteria,1S5RQ@1236|Gammaproteobacteria,1XJIW@135619|Oceanospirillales 135619|Oceanospirillales S Sulfite exporter TauE/SafE - - - - - - - - - - - - TauE k59_1294765_1 1463853.JOHW01000057_gene1940 1.82e-08 61.2 COG0500@1|root,COG2226@2|Bacteria,2GM2N@201174|Actinobacteria 201174|Actinobacteria Q PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_1387685_1 1229909.NSED_02590 1.29e-15 70.1 COG1872@1|root,arCOG04058@2157|Archaea,41TAX@651137|Thaumarchaeota 651137|Thaumarchaeota S DUF167 - - - ko:K09131 - - - - ko00000 - - - DUF167 k59_1387685_2 1131266.ARWQ01000005_gene828 1.46e-111 324.0 COG3253@1|root,arCOG03031@2157|Archaea,41SGX@651137|Thaumarchaeota 651137|Thaumarchaeota S Chlorite dismutase - - - - - - - - - - - - Chlor_dismutase k59_1077520_1 330214.NIDE0003 5.37e-102 318.0 COG0187@1|root,COG0187@2|Bacteria,3J0BB@40117|Nitrospirae 40117|Nitrospirae L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1176015_1 765914.ThisiDRAFT_0699 3.59e-69 218.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,1WYEN@135613|Chromatiales 135613|Chromatiales J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_1176015_2 59538.XP_005959748.1 9.35e-41 142.0 COG0193@1|root,KOG2255@2759|Eukaryota 2759|Eukaryota J aminoacyl-tRNA hydrolase activity - - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - MMR_HSR1,Pept_tRNA_hydro k59_239635_1 314230.DSM3645_21092 5.29e-116 346.0 COG3119@1|root,COG3119@2|Bacteria,2IXNZ@203682|Planctomycetes 203682|Planctomycetes P PFAM sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_508997_2 444860.E3SJ35_9CAUD 5.38e-50 167.0 4QAR1@10239|Viruses,4QUNA@35237|dsDNA viruses no RNA stage,4QPJE@28883|Caudovirales,4QI9Y@10662|Myoviridae 10662|Myoviridae S ATPase family associated with various cellular activities (AAA) - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_970288_1 1122604.JONR01000033_gene45 7.72e-89 293.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,1S0DF@1236|Gammaproteobacteria 1236|Gammaproteobacteria K AAA ATPase domain - - - - - - - - - - - - AAA_16,BTAD,Guanylate_cyc k59_1655659_1 56780.SYN_02416 2.05e-53 175.0 COG1309@1|root,COG1309@2|Bacteria,1MV2V@1224|Proteobacteria,42NW6@68525|delta/epsilon subdivisions,2WPIG@28221|Deltaproteobacteria,2MSD8@213462|Syntrophobacterales 28221|Deltaproteobacteria K YsiA-like protein, C-terminal region - - - ko:K13770 - - - - ko00000,ko03000 - - - TetR_C_4,TetR_N k59_346014_1 1198114.AciX9_1732 2.32e-49 176.0 COG3046@1|root,COG3046@2|Bacteria,3Y47V@57723|Acidobacteria,2JJ03@204432|Acidobacteriia 204432|Acidobacteriia S Deoxyribodipyrimidine photo-lyase-related protein - - - ko:K06876 - - - - ko00000 - - - DPRP,FAD_binding_7 k59_1597265_1 396588.Tgr7_2292 1.21e-160 461.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1WWN1@135613|Chromatiales 135613|Chromatiales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_552658_1 269798.CHU_1734 5.91e-96 291.0 COG0174@1|root,COG0174@2|Bacteria,4NGG2@976|Bacteroidetes,47JHR@768503|Cytophagia 976|Bacteroidetes E PFAM glutamine synthetase catalytic region glnII - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_552660_1 472759.Nhal_2063 3.6e-33 122.0 2E1FD@1|root,32WU2@2|Bacteria,1N5M2@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_14742_1 530564.Psta_1247 2.29e-09 60.8 COG3118@1|root,COG3118@2|Bacteria,2J50V@203682|Planctomycetes 203682|Planctomycetes O ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_14742_2 1403313.AXBR01000002_gene4361 1.84e-10 63.5 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli,1ZAXK@1386|Bacillus 91061|Bacilli C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_761568_1 756499.Desde_3894 1.97e-31 120.0 COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia,260E8@186807|Peptococcaceae 186801|Clostridia C Electron transfer flavoprotein - - - ko:K03521 - - - - ko00000 - - - ETF k59_139227_1 1165094.RINTHH_5420 3.19e-16 78.6 COG2091@1|root,COG2091@2|Bacteria,1G5GA@1117|Cyanobacteria,1HMSA@1161|Nostocales 1117|Cyanobacteria H Belongs to the P-Pant transferase superfamily hetI GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - ko:K06133 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_711737_1 765914.ThisiDRAFT_0827 6.75e-64 211.0 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria,1WZ40@135613|Chromatiales 135613|Chromatiales J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides rnd - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_239686_1 1123393.KB891316_gene2082 5.07e-40 142.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2VHSA@28216|Betaproteobacteria,1KT04@119069|Hydrogenophilales 119069|Hydrogenophilales V Bacitracin resistance protein BacA - - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_1502393_1 1244869.H261_09252 5.95e-62 206.0 COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,1MXK5@1224|Proteobacteria,2U13I@28211|Alphaproteobacteria,2JQVM@204441|Rhodospirillales 204441|Rhodospirillales S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - AMMECR1,Memo k59_182736_1 1041138.KB890233_gene2374 1.04e-25 106.0 COG1028@1|root,COG1028@2|Bacteria,1R413@1224|Proteobacteria,2TW0W@28211|Alphaproteobacteria,4B9Q5@82115|Rhizobiaceae 28211|Alphaproteobacteria IQ Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_1022884_1 698758.AXY_00880 9.94e-12 65.1 COG1539@1|root,COG1539@2|Bacteria,1VA0I@1239|Firmicutes,4HKKK@91061|Bacilli 91061|Bacilli H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB k59_1537640_2 1229909.NSED_07215 1.16e-86 265.0 COG0358@1|root,arCOG04281@2157|Archaea,41S75@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA primase dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Toprim_4 k59_452283_1 935836.JAEL01000003_gene372 1.21e-35 132.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4H9PZ@91061|Bacilli,1ZC9B@1386|Bacillus 91061|Bacilli EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components dppC - - ko:K16201 ko02010,map02010 M00566 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.2 - - BPD_transp_1,OppC_N k59_452283_2 1131269.AQVV01000006_gene529 1.09e-38 137.0 COG0601@1|root,COG0601@2|Bacteria 2|Bacteria P nitrogen compound transport oppB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - ko:K02033,ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 k59_1655755_1 649638.Trad_0146 8.86e-19 88.6 COG1957@1|root,COG1957@2|Bacteria 2|Bacteria F ribosylpyrimidine nucleosidase activity - - - - - - - - - - - - IU_nuc_hydro k59_761597_1 998674.ATTE01000001_gene2587 9.03e-109 343.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,45ZPA@72273|Thiotrichales 72273|Thiotrichales F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_239711_1 109760.SPPG_00943T0 1.81e-49 169.0 2A301@1|root,2RY45@2759|Eukaryota,39WFB@33154|Opisthokonta,3P17R@4751|Fungi 4751|Fungi - - - - - - - - - - - - - - Peripla_BP_2 k59_970365_1 251221.35211992 2.05e-76 241.0 COG0577@1|root,COG0577@2|Bacteria,1G20M@1117|Cyanobacteria 1117|Cyanobacteria V TIGRFAM DevC protein - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_92696_1 754476.Q7A_2199 7.87e-100 299.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,4605M@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1655766_1 1300345.LF41_269 0.000767 45.8 COG4795@1|root,COG4795@2|Bacteria,1NE7M@1224|Proteobacteria 1224|Proteobacteria U Prokaryotic N-terminal methylation motif - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_346098_1 177437.HRM2_17100 5.01e-27 105.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,42M3Y@68525|delta/epsilon subdivisions,2WJH5@28221|Deltaproteobacteria,2MJCG@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_346099_1 1229909.NSED_07450 6.06e-78 249.0 COG0475@1|root,arCOG01956@2157|Archaea 2157|Archaea P Sodium hydrogen exchanger - - - - - - - - - - - - CBS,Na_H_Exchanger k59_552719_1 1123371.ATXH01000004_gene1735 3.47e-68 244.0 COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,2GGV4@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria I CoA enzyme activase uncharacterised domain (DUF2229) - - - - - - - - - - - - BcrAD_BadFG,DUF2229 k59_1537656_1 95619.PM1_0204805 3.56e-104 312.0 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_1537656_2 627192.SLG_11180 2.99e-05 46.6 COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2UBUR@28211|Alphaproteobacteria,2K6D0@204457|Sphingomonadales 204457|Sphingomonadales P Copper chaperone PCu(A)C - - - ko:K09796 - - - - ko00000,ko03110 - - - PCuAC k59_1387779_1 1229909.NSED_08340 7.79e-94 289.0 COG0031@1|root,COG0607@1|root,arCOG01430@2157|Archaea,arCOG02021@2157|Archaea,41SYY@651137|Thaumarchaeota 651137|Thaumarchaeota E Pyridoxal-phosphate dependent enzyme - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1238509_1 264732.Moth_2314 4.04e-43 160.0 COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales 186801|Clostridia C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase sfrB - 1.17.1.10,1.17.1.9,1.97.1.9 ko:K00123,ko:K12527,ko:K15022 ko00450,ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00450,map00630,map00680,map00720,map01100,map01120,map01200 M00377 R00134,R00519,R07229 RC02420,RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3 k59_604917_1 1453496.AT03_14565 3.74e-58 195.0 COG0074@1|root,COG0074@2|Bacteria,1MX67@1224|Proteobacteria,1RQEG@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Protein of unknown function (DUF1116) - - - - - - - - - - - - DUF1116 k59_139285_1 1273125.Rrhod_4316 8.42e-24 105.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FVBU@85025|Nocardiaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain fadD3 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0051087 6.2.1.41 ko:K18687 ko00984,ko01100,ko01120,map00984,map01100,map01120 - R10769 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_139285_2 298654.FraEuI1c_2034 7.68e-73 231.0 COG2124@1|root,COG2124@2|Bacteria,2GJ3T@201174|Actinobacteria 201174|Actinobacteria Q cytochrome P450 - - - - - - - - - - - - p450 k59_1332357_1 1123489.AUAN01000005_gene1609 9.65e-25 103.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,4H2M3@909932|Negativicutes 909932|Negativicutes S Belongs to the CinA family cinA - 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth k59_1332357_2 671143.DAMO_2617 2.25e-13 68.9 COG1514@1|root,COG1514@2|Bacteria,2NPRT@2323|unclassified Bacteria 2|Bacteria J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester ligT GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase k59_921142_1 580327.Tthe_1381 3.14e-26 105.0 COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,42GGH@68295|Thermoanaerobacterales 186801|Clostridia S SMART phosphoesterase PHP domain protein trpH - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_921142_2 330214.NIDE1532 4.91e-51 171.0 COG1539@1|root,COG2520@1|root,COG1539@2|Bacteria,COG2520@2|Bacteria 2|Bacteria J tRNA (guanine(37)-N(1))-methyltransferase activity folB - 1.13.11.81,2.1.1.228,3.1.3.18,4.1.2.25,5.1.99.8 ko:K01091,ko:K01633,ko:K15429 ko00630,ko00790,ko01100,ko01110,ko01130,map00630,map00790,map01100,map01110,map01130 M00126,M00840 R00597,R01334,R03504,R11037,R11073 RC00003,RC00017,RC00334,RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000,ko03016 - - - FolB,rRNA_methylase k59_182777_1 56780.SYN_00817 2.06e-45 160.0 COG0438@1|root,COG0438@2|Bacteria,1R564@1224|Proteobacteria,42RYD@68525|delta/epsilon subdivisions,2X5EZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_667980_1 497964.CfE428DRAFT_5013 1.4e-59 192.0 COG0363@1|root,COG0363@2|Bacteria 2|Bacteria G glucosamine-6-phosphate deaminase activity nagB - 3.1.1.31,3.5.99.6 ko:K01057,ko:K02564 ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R00765,R02035 RC00163,RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_1655801_1 1379270.AUXF01000004_gene3104 4.33e-113 348.0 COG0433@1|root,COG0433@2|Bacteria,1ZURZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S COG0433 Predicted ATPase - - - ko:K06915 - - - - ko00000 - - - - k59_604930_1 743299.Acife_2948 1.1e-119 349.0 COG3267@1|root,COG3267@2|Bacteria,1REWJ@1224|Proteobacteria,1S518@1236|Gammaproteobacteria,2NDDW@225057|Acidithiobacillales 225057|Acidithiobacillales U AAA ATPase domain - - - - - - - - - - - - AAA_22 k59_1446391_1 493475.GARC_0274 5.28e-29 116.0 COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,1RP9M@1236|Gammaproteobacteria,46B1V@72275|Alteromonadaceae 1236|Gammaproteobacteria S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_876127_2 671143.DAMO_0768 1.98e-141 421.0 COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria 2|Bacteria C Cytochrome b(N-terminal)/b6/petB petB - - - - - - - - - - - Cytochrom_B_C,Cytochrome_B k59_356727_1 330214.NIDE0165 7.35e-112 324.0 COG2197@1|root,COG2197@2|Bacteria,3J18V@40117|Nitrospirae 40117|Nitrospirae K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_249520_1 395963.Bind_1027 1.11e-41 152.0 COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,2TSVE@28211|Alphaproteobacteria,3NC4M@45404|Beijerinckiaceae 28211|Alphaproteobacteria C PFAM FAD linked oxidase domain protein - - 1.1.3.8,1.1.98.3 ko:K00103,ko:K16653 ko00053,ko01100,map00053,map01100 M00129 R00647,R03184,R10053 RC00195,RC00346,RC00869 ko00000,ko00001,ko00002,ko01000 - - - ALO,FAD_binding_4 k59_407375_1 1265502.KB905972_gene1336 6.79e-57 187.0 COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,2VKSA@28216|Betaproteobacteria,4AANE@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF3641) - - - - - - - - - - - - DUF3641,Fer4_12,Radical_SAM k59_304772_1 87626.PTD2_10138 6.18e-65 220.0 COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,1RNG8@1236|Gammaproteobacteria,2PZVD@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P Alkaline phosphatase homologues phoA - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase k59_192220_1 637905.SVI_0004 1.44e-64 212.0 COG1622@1|root,COG2863@1|root,COG1622@2|Bacteria,COG2863@2|Bacteria,1MVYW@1224|Proteobacteria,1RY2R@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG1622 Heme copper-type cytochrome quinol oxidases, subunit 2 - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrom_C k59_304781_1 247490.KSU1_C0571 1.49e-35 134.0 COG2204@1|root,COG2204@2|Bacteria,2IY95@203682|Planctomycetes 203682|Planctomycetes T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1604878_1 1262449.CP6013_2203 6.09e-31 115.0 COG1610@1|root,COG1610@2|Bacteria,1V6F2@1239|Firmicutes,24JB0@186801|Clostridia,36IQS@31979|Clostridiaceae 186801|Clostridia S GatB Yqey domain protein yqeY - - ko:K09117 - - - - ko00000 - - - YqeY k59_1604878_2 537007.BLAHAN_05767 3.2e-08 55.5 COG0685@1|root,COG0685@2|Bacteria,1TQFE@1239|Firmicutes,247ZK@186801|Clostridia,3Y08F@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_1032642_1 1123399.AQVE01000015_gene1812 1.97e-39 146.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,45ZRX@72273|Thiotrichales 72273|Thiotrichales E Belongs to the peptidase M24B family - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_562475_1 1408303.JNJJ01000003_gene998 1.41e-32 124.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4H9PZ@91061|Bacilli,1ZC9B@1386|Bacillus 91061|Bacilli EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components dppC - - ko:K16201 ko02010,map02010 M00566 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.2 - - BPD_transp_1,OppC_N k59_876160_1 1230476.C207_00082 2.01e-55 186.0 COG1960@1|root,COG1960@2|Bacteria,1MUUX@1224|Proteobacteria,2TSMF@28211|Alphaproteobacteria,3JXQT@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - ko:K04117 ko00362,ko01120,map00362,map01120 M00540 R05619 RC02035 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_407392_1 177437.HRM2_17080 3.13e-117 350.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2WIQU@28221|Deltaproteobacteria,2MHQM@213118|Desulfobacterales 28221|Deltaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1340900_2 1121428.DESHY_110507___1 1.09e-35 128.0 COG2050@1|root,COG2050@2|Bacteria,1V824@1239|Firmicutes,24R76@186801|Clostridia,262I1@186807|Peptococcaceae 186801|Clostridia Q PFAM thioesterase superfamily - - - - - - - - - - - - 4HBT k59_1340900_3 136993.KB900626_gene1795 5.71e-12 62.4 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2U956@28211|Alphaproteobacteria,36YB9@31993|Methylocystaceae 28211|Alphaproteobacteria FG HIT domain MA20_36190 - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_356760_1 533247.CRD_01985 3.55e-16 79.7 COG4221@1|root,COG4221@2|Bacteria,1G3EF@1117|Cyanobacteria,1HINI@1161|Nostocales 1117|Cyanobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1547173_1 1123401.JHYQ01000022_gene1130 3.74e-85 262.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,45ZSB@72273|Thiotrichales 72273|Thiotrichales M Arabinose 5-phosphate isomerase kdsD - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_876173_2 497964.CfE428DRAFT_3459 1.88e-09 60.5 COG2304@1|root,COG2304@2|Bacteria,46TTR@74201|Verrucomicrobia 74201|Verrucomicrobia S von Willebrand factor type A domain - - - - - - - - - - - - BatA,VWA k59_1140385_1 1218075.BAYA01000004_gene1260 4.09e-11 63.9 COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,2VSFV@28216|Betaproteobacteria,1K4E5@119060|Burkholderiaceae 28216|Betaproteobacteria O Thiol disulfide interchange protein dsbA - - ko:K03673 ko01503,map01503 M00728 - - ko00000,ko00001,ko00002,ko03110 - - - DSBA,Thioredoxin k59_1184627_1 448385.sce2503 6.12e-93 300.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,42M5P@68525|delta/epsilon subdivisions,2WIW8@28221|Deltaproteobacteria,2YUB7@29|Myxococcales 28221|Deltaproteobacteria KL Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_407410_1 1123371.ATXH01000021_gene1117 1.49e-31 129.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GHDG@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_562488_1 1449049.JONW01000005_gene1177 7.39e-20 93.2 COG3900@1|root,COG3900@2|Bacteria,1RKQP@1224|Proteobacteria,2VEWI@28211|Alphaproteobacteria 28211|Alphaproteobacteria S periplasmic protein - - - - - - - - - - - - DUF2092 k59_562488_2 1121440.AUMA01000001_gene92 7.02e-21 95.5 COG1579@1|root,COG1579@2|Bacteria,1R7GT@1224|Proteobacteria,42P3S@68525|delta/epsilon subdivisions,2WKVG@28221|Deltaproteobacteria,2M888@213115|Desulfovibrionales 28221|Deltaproteobacteria S C4-type zinc ribbon domain - - - ko:K07164 - - - - ko00000 - - - zf-RING_7 k59_562488_3 1423814.HMPREF0549_0505 0.000188 46.6 COG0328@1|root,COG0328@2|Bacteria,1VH2B@1239|Firmicutes,4HIY9@91061|Bacilli,3F7JC@33958|Lactobacillaceae 91061|Bacilli L Ribonuclease HI rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H,RVT_3 k59_192255_1 555778.Hneap_1255 2.38e-30 113.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,1RQ7F@1236|Gammaproteobacteria,1X0SD@135613|Chromatiales 135613|Chromatiales O Redoxin - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_1669683_1 1005999.GLGR_1679 2.14e-69 235.0 COG5164@1|root,COG5164@2|Bacteria,1MX1Z@1224|Proteobacteria,1T5GM@1236|Gammaproteobacteria 1236|Gammaproteobacteria K regulation of DNA-templated transcription, elongation - - - - - - - - - - - - - k59_1184641_1 1183438.GKIL_3161 2.53e-17 85.5 COG2211@1|root,COG2211@2|Bacteria,1G0ZY@1117|Cyanobacteria 1117|Cyanobacteria G COG2211 Na melibiose symporter and related melB - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_1547209_2 1207055.C100_13845 1.91e-14 77.8 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K01C@204457|Sphingomonadales 204457|Sphingomonadales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,Response_reg k59_978505_1 330214.NIDE0517 4.79e-99 299.0 COG5621@1|root,COG5621@2|Bacteria,3J19I@40117|Nitrospirae 40117|Nitrospirae S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 k59_1088249_1 1229909.NSED_08480 1.46e-106 321.0 COG1290@1|root,arCOG01721@2157|Archaea,41SDA@651137|Thaumarchaeota 651137|Thaumarchaeota C Cytochrome b subunit of the bc complex - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_1547214_2 859657.RPSI07_2435 1.37e-55 185.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VJ15@28216|Betaproteobacteria,1K4KC@119060|Burkholderiaceae 28216|Betaproteobacteria E Pyridoxal-phosphate dependent enzyme - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_356808_1 1500257.JQNM01000014_gene2919 1.33e-55 184.0 COG4638@1|root,COG4638@2|Bacteria,1MX47@1224|Proteobacteria,2TV03@28211|Alphaproteobacteria,4B9MF@82115|Rhizobiaceae 28211|Alphaproteobacteria P Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_771027_1 1207063.P24_06237 4.15e-22 100.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TTBG@28211|Alphaproteobacteria,2JPA6@204441|Rhodospirillales 204441|Rhodospirillales P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC k59_1669723_1 1380394.JADL01000002_gene1807 1.18e-44 147.0 2CJ4Q@1|root,32S97@2|Bacteria,1N0B9@1224|Proteobacteria,2U72B@28211|Alphaproteobacteria,2JYH0@204441|Rhodospirillales 204441|Rhodospirillales S EthD domain - - - - - - - - - - - - EthD k59_771036_1 1499683.CCFF01000014_gene4058 1.36e-40 149.0 COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,36DFC@31979|Clostridiaceae 186801|Clostridia S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_103432_1 1500257.JQNM01000010_gene639 3.63e-22 94.7 COG0436@1|root,COG0436@2|Bacteria,1MX43@1224|Proteobacteria,2TV9C@28211|Alphaproteobacteria,4B9EH@82115|Rhizobiaceae 28211|Alphaproteobacteria E Aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 k59_1032718_1 1049564.TevJSym_ar00380 7.55e-17 82.0 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1QYEW@1224|Proteobacteria,1T3PI@1236|Gammaproteobacteria,1JAK0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_5,Pyr_redox_3 k59_1604928_1 1049564.TevJSym_bk00230 1.45e-166 484.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Alpha amylase catalytic ams - 2.4.1.4,3.2.1.1,5.4.99.16 ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_1340964_2 1283300.ATXB01000001_gene392 1.26e-24 103.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_721723_1 330214.NIDE2211 8.04e-95 283.0 COG1208@1|root,COG1208@2|Bacteria 2|Bacteria JM COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon rmlA GO:0000166,GO:0000270,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006040,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019752,GO:0030203,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044281,GO:0046872,GO:0070569,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.7.13,2.7.7.24,2.7.7.99 ko:K00966,ko:K00973,ko:K00992 ko00051,ko00520,ko00521,ko00523,ko00525,ko01100,ko01110,ko01130,map00051,map00520,map00521,map00523,map00525,map01100,map01110,map01130 M00114,M00361,M00362,M00793 R00885,R02328,R11025 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transf_3,NTP_transferase k59_1088287_1 857087.Metme_1059 5.62e-97 301.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1XDPF@135618|Methylococcales 135618|Methylococcales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_19314_1 1248232.BANQ01000099_gene1272 2.36e-87 276.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1XSTB@135623|Vibrionales 135623|Vibrionales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_1396356_1 591157.SSLG_00500 3.26e-05 45.1 2BGX2@1|root,32AX0@2|Bacteria,2IIA3@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1396356_3 1246445.ANAY01000009_gene1272 8.11e-15 75.1 COG1351@1|root,COG1351@2|Bacteria,2HM6U@201174|Actinobacteria,4EMK7@85012|Streptosporangiales 201174|Actinobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_931934_1 1278309.KB907100_gene1817 3.84e-10 62.4 COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,1RQ6M@1236|Gammaproteobacteria,1XJNR@135619|Oceanospirillales 135619|Oceanospirillales I Belongs to the CDS family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_931934_2 1273538.G159_10850 9.06e-18 81.3 COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,4HA37@91061|Bacilli,26DVC@186818|Planococcaceae 91061|Bacilli I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_19791_1 243090.RB3579 2.57e-12 72.0 COG4188@1|root,COG4188@2|Bacteria,2IZRN@203682|Planctomycetes 203682|Planctomycetes S dienelactone hydrolase - - - - - - - - - - - - PAF-AH_p_II k59_1141853_2 713586.KB900536_gene2241 1.35e-50 171.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1WW00@135613|Chromatiales 135613|Chromatiales H Belongs to the ALAD family - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_149654_1 471223.GWCH70_2446 5.56e-11 60.5 COG0268@1|root,COG0268@2|Bacteria,1VEGX@1239|Firmicutes,4HNJS@91061|Bacilli,1WGNI@129337|Geobacillus 91061|Bacilli J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_149654_2 1150474.JQJI01000014_gene742 5.69e-20 85.5 COG0176@1|root,COG0176@2|Bacteria,2GC05@200918|Thermotogae 200918|Thermotogae F Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM0295 TAL_FSA k59_563662_2 330214.NIDE0031 2.74e-70 221.0 COG1566@1|root,COG1566@2|Bacteria,3J0TB@40117|Nitrospirae 40117|Nitrospirae V HlyD family secretion protein - - - ko:K01993 - - - - ko00000 - - - HlyD_D23 k59_250731_1 1454004.AW11_00495 6.13e-101 303.0 COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2VH6H@28216|Betaproteobacteria 28216|Betaproteobacteria G Glucose sorbosone yliI - - ko:K21430 - - - - ko00000,ko01000 - - - GSDH k59_250739_1 1049564.TevJSym_bb00140 1.56e-100 301.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1J4VC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG4972 Tfp pilus assembly protein, ATPase PilM pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_979370_1 400682.PAC_15703455 4.74e-64 218.0 COG1331@1|root,KOG2244@2759|Eukaryota 2759|Eukaryota O spermatogenesis - - - - - - - - - - - - Glyco_hydro_9,Thioredox_DsbH k59_1089501_1 999541.bgla_1g20980 2.24e-44 153.0 COG0517@1|root,COG0517@2|Bacteria,1RE9W@1224|Proteobacteria,2VRIH@28216|Betaproteobacteria,1K4C0@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM CBS domain containing protein - - - - - - - - - - - - BON,CBS k59_1248878_1 1096930.L284_13875 3.74e-41 142.0 COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,2U9GG@28211|Alphaproteobacteria,2K4C9@204457|Sphingomonadales 204457|Sphingomonadales I MaoC like domain - - - - - - - - - - - - MaoC_dehydratas k59_204199_1 290315.Clim_2168 1.72e-10 67.0 COG1215@1|root,COG1215@2|Bacteria,1FDR6@1090|Chlorobi 1090|Chlorobi M PFAM glycosyl transferase family 2 - - - ko:K14597 ko00906,map00906 - R07544,R07546 RC00262 ko00000,ko00001 - - - Glyco_tranf_2_3,Glycos_transf_2 k59_23570_1 666684.AfiDRAFT_3384 3.62e-23 106.0 COG3206@1|root,COG3206@2|Bacteria,1RK0N@1224|Proteobacteria,2TSFQ@28211|Alphaproteobacteria,3JS8J@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Chain length determinant protein - - - - - - - - - - - - GNVR,Wzz k59_1558724_1 1049564.TevJSym_as00150 8.16e-53 187.0 COG0586@1|root,COG0586@2|Bacteria,1R0F3@1224|Proteobacteria,1RPDS@1236|Gammaproteobacteria,1JAB5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Acid phosphatase homologues lssY - - ko:K03975 - - - - ko00000 - - - LssY_C,PAP2,SNARE_assoc k59_571369_1 1185766.DL1_18115 1.5e-74 236.0 COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2TQZC@28211|Alphaproteobacteria,2XKM3@285107|Thioclava 28211|Alphaproteobacteria E ABC transporter permease - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_779342_1 301.JNHE01000001_gene451 5.96e-100 318.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1YDIF@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria P Cation transporter/ATPase, N-terminus ctpF - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_779347_1 1123508.JH636443_gene4974 1.37e-88 290.0 COG3391@1|root,COG3391@2|Bacteria,2IX7F@203682|Planctomycetes 203682|Planctomycetes M Phosphoesterase family - - - - - - - - - - - - Lactonase,Phosphoesterase k59_626380_1 338966.Ppro_0674 2.24e-96 313.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,43UIG@69541|Desulfuromonadales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1195689_1 244581.IM40_07240 0.000454 42.7 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria,47EYA@766|Rickettsiales 766|Rickettsiales C Catalyzes the reversible oxidation of malate to oxaloacetate mdh GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_1195689_2 452637.Oter_1158 6.84e-14 71.2 2BYAB@1|root,32R2Z@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_730420_1 757424.Hsero_2499 2.47e-36 139.0 COG3280@1|root,COG3280@2|Bacteria,1QTVK@1224|Proteobacteria,2VIQ0@28216|Betaproteobacteria 28216|Betaproteobacteria G synthase treY - 5.4.99.15 ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R09995 - ko00000,ko00001,ko00002,ko01000 - GH13 - Alpha-amylase k59_730420_2 861299.J421_3811 2.32e-11 64.3 COG1640@1|root,COG1640@2|Bacteria,1ZU23@142182|Gemmatimonadetes 142182|Gemmatimonadetes G 4-alpha-glucanotransferase - - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_626389_1 1336243.JAEA01000003_gene2183 9.81e-124 368.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2TSMA@28211|Alphaproteobacteria,1JR9A@119045|Methylobacteriaceae 28211|Alphaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_1195697_1 323848.Nmul_A2506 8.39e-27 114.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,3720Z@32003|Nitrosomonadales 28216|Betaproteobacteria S Competence protein ComEC Rec2 comA - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_258397_1 358681.BBR47_15200 2.49e-24 105.0 COG0247@1|root,COG0247@2|Bacteria,1TR46@1239|Firmicutes,4HAY9@91061|Bacilli,26U26@186822|Paenibacillaceae 91061|Bacilli C 4Fe-4S dicluster domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_8 k59_884750_1 1217718.ALOU01000010_gene877 2e-49 178.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,1JZT2@119060|Burkholderiaceae 28216|Betaproteobacteria T adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc k59_1351950_1 1114964.L485_17920 4.36e-74 236.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the thiolase family vraB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_204344_1 338966.Ppro_2623 5.37e-07 50.1 COG3668@1|root,COG3668@2|Bacteria,1N8NU@1224|Proteobacteria,42UWI@68525|delta/epsilon subdivisions,2WQYD@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM plasmid stabilization system - - - - - - - - - - - - ParE_toxin k59_1195735_1 765420.OSCT_2683 8.8e-55 185.0 COG0003@1|root,COG0003@2|Bacteria,2G64V@200795|Chloroflexi,375AR@32061|Chloroflexia 32061|Chloroflexia P PFAM Anion-transporting ATPase - - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase k59_1351963_1 518766.Rmar_2014 1.48e-27 114.0 COG3420@1|root,COG3420@2|Bacteria,4NEGT@976|Bacteroidetes,1FJC4@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P Domain present in carbohydrate binding proteins and sugar hydrolses nosD - - ko:K07218 - - - - ko00000 - - - NosD k59_1351963_2 326424.FRAAL3128 4.72e-05 45.1 COG0411@1|root,COG0559@1|root,COG4177@1|root,COG0411@2|Bacteria,COG0559@2|Bacteria,COG4177@2|Bacteria,2GJHR@201174|Actinobacteria,4EU9I@85013|Frankiales 201174|Actinobacteria P Belongs to the binding-protein-dependent transport system permease family - - - - - - - - - - - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_1195742_1 93220.LV28_12470 2.37e-76 243.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VJ9G@28216|Betaproteobacteria,1K0VU@119060|Burkholderiaceae 28216|Betaproteobacteria O Belongs to the peptidase S1C family degQ - - ko:K04691,ko:K04772 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Trypsin_2 k59_1195747_1 1380391.JIAS01000014_gene2112 8.37e-77 244.0 COG5598@1|root,COG5598@2|Bacteria,1MX73@1224|Proteobacteria,2TS1M@28211|Alphaproteobacteria,2JVS6@204441|Rhodospirillales 204441|Rhodospirillales H Trimethylamine methyltransferase (MTTB) - - - - - - - - - - - - MTTB k59_204365_1 396588.Tgr7_1592 2.4e-12 68.2 COG2344@1|root,COG2344@2|Bacteria,1NXDK@1224|Proteobacteria,1RN7N@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate ddh - 1.4.1.16 ko:K03340 ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230 M00526 R02755 RC00006 ko00000,ko00001,ko00002,ko01000 - - - DAPDH_C k59_23616_1 519989.ECTPHS_03939 1.09e-92 281.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1WX16@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_23619_1 1033802.SSPSH_001227 5.49e-22 95.1 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,1RPM0@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - iSF_1195.SF3422,iUTI89_1310.UTI89_C3903 PEPCK_ATP k59_990114_1 349124.Hhal_0038 3.98e-22 99.0 COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,1RNF3@1236|Gammaproteobacteria,1WWVY@135613|Chromatiales 135613|Chromatiales T PFAM MucB RseB - - - ko:K03598 - - - - ko00000,ko03021 - - - MucB_RseB,MucB_RseB_C k59_730497_1 1469245.JFBG01000084_gene200 2.64e-141 417.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1WX7K@135613|Chromatiales 135613|Chromatiales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_1195787_1 1255043.TVNIR_3530 9.63e-38 137.0 COG0457@1|root,COG0457@2|Bacteria,1R4UV@1224|Proteobacteria,1S19J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S pct identical to residues 1 to 347 of 347 from GenPept.129 gb AAD44731.1 AF141323_2 (AF141323) ShiA Shigella flexneri - - - - - - - - - - - - - k59_1558934_1 1182553.XP_007742502.1 2.16e-15 78.6 COG0412@1|root,2RYJ9@2759|Eukaryota,38F6H@33154|Opisthokonta,3P0P6@4751|Fungi,3QQAC@4890|Ascomycota,20D2G@147545|Eurotiomycetes,3MQC1@451870|Chaetothyriomycetidae 4751|Fungi Q dienelactone hydrolase - - - - - - - - - - - - SnoaL,SnoaL_2 k59_258491_1 717772.THIAE_01640 2.53e-14 72.4 COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,1RQCM@1236|Gammaproteobacteria,462QK@72273|Thiotrichales 72273|Thiotrichales S Pfam:UPF0118 - - - - - - - - - - - - AI-2E_transport k59_730528_1 55601.VANGNB10_cI0427 6.23e-84 257.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1XSZ3@135623|Vibrionales 135623|Vibrionales J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_626554_2 331869.BAL199_12936 2.47e-113 336.0 COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2TRMA@28211|Alphaproteobacteria,4BREC@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_990189_1 349521.HCH_04415 1.13e-11 62.8 COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1S90Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria C cytochrome - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_1559007_1 105559.Nwat_2309 5.69e-59 197.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1WWDA@135613|Chromatiales 135613|Chromatiales J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_990213_1 234831.PSM_A2651 2.14e-148 450.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,2PZNZ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cusA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_626582_1 386456.JQKN01000011_gene782 3.95e-08 60.1 arCOG03439@1|root,arCOG03439@2157|Archaea 2157|Archaea L PFAM periplasmic copper-binding - - - - - - - - - - - - Beta_helix,Big_3_3,NosD,Peptidase_C1 k59_779479_1 1121918.ARWE01000001_gene3297 1.39e-30 119.0 COG0644@1|root,COG0644@2|Bacteria,1R4JF@1224|Proteobacteria 1224|Proteobacteria C COG0644 Dehydrogenases (flavoproteins) - - - - - - - - - - - - HI0933_like,NAD_binding_8 k59_626606_1 1366050.N234_07740 1.19e-77 244.0 COG3395@1|root,COG3395@2|Bacteria,1MW4G@1224|Proteobacteria,2VI5S@28216|Betaproteobacteria,1K3VK@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM type III effector Hrp-dependent outers hop - 2.7.1.217 ko:K21948 - - R11706,R11707 - ko00000,ko01000 - - - DUF1357_C,DUF1537 k59_208779_2 1246474.ANBE01000032_gene3216 4.45e-44 157.0 COG0277@1|root,COG0277@2|Bacteria,2GKQR@201174|Actinobacteria,4EFTT@85012|Streptosporangiales 201174|Actinobacteria C FAD binding domain - - - - - - - - - - - - FAD_binding_4 k59_574323_1 502025.Hoch_5784 5.53e-143 418.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,42MPG@68525|delta/epsilon subdivisions,2WKW8@28221|Deltaproteobacteria 28221|Deltaproteobacteria HJ RimK-like ATPgrasp N-terminal domain - - - - - - - - - - - - Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK k59_1410269_2 1038858.AXBA01000004_gene161 1.67e-07 57.4 COG0500@1|root,COG0500@2|Bacteria,1QV5S@1224|Proteobacteria,2TWAD@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_574339_1 416348.Hlac_1336 8.91e-83 257.0 COG1140@1|root,arCOG01501@2157|Archaea,2XVCI@28890|Euryarchaeota,23S7Y@183963|Halobacteria 183963|Halobacteria C COG1140 Nitrate reductase beta subunit narH - - ko:K17051 - - - - ko00000,ko02000 5.A.3.8 - - Fer4_11 k59_1043806_1 1521187.JPIM01000008_gene2103 2.82e-102 305.0 COG1089@1|root,COG1089@2|Bacteria,2G5P2@200795|Chloroflexi,375CR@32061|Chloroflexia 32061|Chloroflexia M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_1354809_1 351348.Maqu_1728 7.4e-75 239.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,464HQ@72275|Alteromonadaceae 1236|Gammaproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 CBS,IMPDH,NMO k59_1043821_1 86416.Clopa_0410 5.33e-54 179.0 COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,36EBG@31979|Clostridiaceae 186801|Clostridia E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_24823_1 330214.NIDE0794 6.26e-61 199.0 COG0416@1|root,COG0416@2|Bacteria,3J0DY@40117|Nitrospirae 40117|Nitrospirae I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_1043841_1 1123274.KB899412_gene1409 2.55e-26 110.0 COG0043@1|root,COG0043@2|Bacteria 2|Bacteria H 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity ubiD - 4.1.1.98 ko:K03182,ko:K16874 ko00130,ko00365,ko01100,ko01110,ko01120,map00130,map00365,map01100,map01110,map01120 M00117 R04985,R04986,R10213 RC00391,RC03086 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_208886_1 1128421.JAGA01000003_gene2871 2.84e-53 181.0 COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria 2|Bacteria C Polysulphide reductase, NrfD nrfD - - ko:K00185 - - - - ko00000 5.A.3 - - DUF3341,NrfD k59_208886_2 1298867.AUES01000042_gene3579 1.76e-13 70.9 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2TTE2@28211|Alphaproteobacteria,3K6FA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C 4Fe-4S dicluster domain - - - ko:K00124,ko:K00184,ko:K18362 ko00360,ko00630,ko00680,ko01100,ko01120,ko01200,map00360,map00630,map00680,map01100,map01120,map01200 - R00519,R07222,R07294 RC00004,RC01844,RC01903,RC02796 ko00000,ko00001 5.A.3 - - Fer4_11,Fer4_4,Fer4_7,Molydop_binding k59_208887_1 926550.CLDAP_16780 1.62e-112 337.0 COG5598@1|root,COG5598@2|Bacteria 2|Bacteria H trimethylamine methyltransferase - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB k59_574386_1 713587.THITH_15655 4.89e-88 273.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1WVW0@135613|Chromatiales 135613|Chromatiales H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_574387_1 402777.KB235904_gene4743 1.14e-122 373.0 COG3957@1|root,COG3957@2|Bacteria,1G0B2@1117|Cyanobacteria,1H7CT@1150|Oscillatoriales 1117|Cyanobacteria G D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase - - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_1563394_1 161156.JQKW01000001_gene1404 7.21e-146 423.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2GHPG@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_1563423_1 1348635.BBJY01000009_gene1543 7.08e-11 62.0 COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,1XSYN@135623|Vibrionales 135623|Vibrionales J With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P epmA GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 - ko:K04568 - - - - ko00000,ko01000,ko03012 - - - tRNA-synt_2 k59_887477_1 439375.Oant_3038 0.000217 49.3 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,1J1UB@118882|Brucellaceae 28211|Alphaproteobacteria S Insulinase (Peptidase family M16) MA20_05655 - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_887509_1 883113.HMPREF9708_00820 4.48e-17 81.6 COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,4HA4R@91061|Bacilli,27DJF@186827|Aerococcaceae 91061|Bacilli J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_1614749_1 1158150.KB906247_gene2297 4.15e-69 220.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1WW8T@135613|Chromatiales 135613|Chromatiales M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_1614749_2 629265.PMA4326_05251 7.34e-78 243.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1Z91I@136849|Pseudomonas syringae group 1236|Gammaproteobacteria F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_1354929_1 1125863.JAFN01000001_gene1170 2.76e-12 68.9 COG1285@1|root,COG1285@2|Bacteria,1MURJ@1224|Proteobacteria,42VSX@68525|delta/epsilon subdivisions,2WS1I@28221|Deltaproteobacteria 28221|Deltaproteobacteria S MgtC family - - - ko:K07507 - - - - ko00000,ko02000 9.B.20 - - MgtC k59_887526_1 1380358.JADJ01000007_gene3082 1.51e-18 87.8 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1XHYK@135619|Oceanospirillales 135619|Oceanospirillales O Cytochrome c-type biogenesis protein ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_1198940_1 1408254.T458_11980 1.32e-06 50.1 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4HBMF@91061|Bacilli,26R6I@186822|Paenibacillaceae 91061|Bacilli V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1354933_1 765911.Thivi_4062 1.59e-37 141.0 COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,1S9D2@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_574492_2 304371.MCP_2273 1.88e-11 65.1 arCOG00787@1|root,arCOG00787@2157|Archaea 2157|Archaea L UvrD REP helicase - - 3.6.4.12 ko:K03657,ko:K07465 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_574498_1 118163.Ple7327_2554 2.66e-26 115.0 COG0661@1|root,COG0661@2|Bacteria,1G1KC@1117|Cyanobacteria,3VJEE@52604|Pleurocapsales 1117|Cyanobacteria S PFAM ABC1 family - - - - - - - - - - - - ABC1 k59_421549_1 715226.ABI_04280 9.26e-37 140.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2TQN6@28211|Alphaproteobacteria,2KFJ0@204458|Caulobacterales 204458|Caulobacterales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_421549_2 1255043.TVNIR_2752 0.000747 42.4 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WWGD@135613|Chromatiales 135613|Chromatiales T response regulator - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1570390_1 232721.Ajs_1757 8.54e-67 224.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,4AA75@80864|Comamonadaceae 28216|Betaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_1258065_1 6412.HelroP83507 6.36e-12 68.9 COG0560@1|root,KOG1615@2759|Eukaryota,38F2C@33154|Opisthokonta,3BDNF@33208|Metazoa,3CZRC@33213|Bilateria 33208|Metazoa E phosphoserine phosphatase activity PSPH GO:0000003,GO:0000287,GO:0000902,GO:0000904,GO:0003674,GO:0003824,GO:0004647,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006793,GO:0006796,GO:0006807,GO:0006928,GO:0006935,GO:0007275,GO:0007399,GO:0007409,GO:0007411,GO:0007422,GO:0007610,GO:0007617,GO:0007618,GO:0007619,GO:0008049,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009605,GO:0009612,GO:0009628,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016043,GO:0016053,GO:0016311,GO:0016545,GO:0016787,GO:0016788,GO:0016791,GO:0019098,GO:0019752,GO:0019953,GO:0022008,GO:0022414,GO:0030030,GO:0030154,GO:0030182,GO:0030534,GO:0031175,GO:0031667,GO:0032501,GO:0032502,GO:0032504,GO:0032989,GO:0032990,GO:0033574,GO:0033993,GO:0040011,GO:0042221,GO:0042330,GO:0042493,GO:0042578,GO:0042802,GO:0042803,GO:0042995,GO:0043005,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044703,GO:0045433,GO:0045471,GO:0046394,GO:0046677,GO:0046872,GO:0046983,GO:0048065,GO:0048149,GO:0048468,GO:0048609,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0050896,GO:0051704,GO:0060179,GO:0061564,GO:0071704,GO:0071840,GO:0097305,GO:0097458,GO:0097485,GO:0120025,GO:0120036,GO:0120039,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901654,GO:1901700 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - HAD,Hydrolase k59_734945_1 95619.PM1_0203355 6.32e-51 166.0 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Required for maturation of 30S ribosomal subunits rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_734945_2 314278.NB231_03772 1.6e-39 144.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales 135613|Chromatiales K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_787977_1 118173.KB235914_gene1215 8.46e-05 47.0 COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H8WC@1150|Oscillatoriales 1117|Cyanobacteria T Response regulator receiver domain - - - - - - - - - - - - EAL,GGDEF,Response_reg k59_1622958_1 444859.E3SIB3_9CAUD 4.96e-17 87.8 4QEE7@10239|Viruses,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae 10662|Myoviridae S Pfam:DUF4815 - - - - - - - - - - - - - k59_631341_1 3827.XP_004503141.1 1.55e-76 256.0 COG0265@1|root,KOG1421@2759|Eukaryota,37M01@33090|Viridiplantae,3G8IE@35493|Streptophyta,4JN34@91835|fabids 35493|Streptophyta O protease Do-like - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009314,GO:0009416,GO:0009507,GO:0009536,GO:0009628,GO:0009642,GO:0009644,GO:0009892,GO:0010109,GO:0010205,GO:0016787,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0042548,GO:0043155,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043467,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0071704,GO:0140096,GO:1901564,GO:1905156 - - - - - - - - - - PDZ_1,PDZ_2,Trypsin_2 k59_631341_2 984262.SGRA_2018 3.5e-10 60.5 COG0003@1|root,COG0003@2|Bacteria,4P52N@976|Bacteroidetes,1IZXV@117747|Sphingobacteriia 976|Bacteroidetes P Anion-transporting ATPase - - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase k59_1258071_1 330214.NIDE1108 1.04e-65 222.0 COG1193@1|root,COG1193@2|Bacteria,3J0Y0@40117|Nitrospirae 40117|Nitrospirae L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr k59_1466453_2 1123499.KB908022_gene1136 5.39e-18 88.2 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2VHNK@28216|Betaproteobacteria,2KPK8@206351|Neisseriales 206351|Neisseriales D CobQ CobB MinD ParA nucleotide binding domain protein soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1517305_1 1051632.TPY_1667 6.39e-49 169.0 COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,3WCDK@538999|Clostridiales incertae sedis 186801|Clostridia C PFAM Acyl-CoA dehydrogenase, C-terminal domain bcd - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_683508_1 298653.Franean1_1410 3.45e-133 391.0 COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria,4EU55@85013|Frankiales 201174|Actinobacteria P PFAM Rieske 2Fe-2S domain protein - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_1100732_1 330214.NIDE2046 2.11e-109 325.0 COG0133@1|root,COG0133@2|Bacteria,3J0E1@40117|Nitrospirae 40117|Nitrospirae E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1100735_1 1125863.JAFN01000001_gene1008 9.59e-60 206.0 COG0204@1|root,COG1647@1|root,COG0204@2|Bacteria,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,42NBK@68525|delta/epsilon subdivisions,2WIUP@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Serine aminopeptidase, S33 - - 3.1.1.1 ko:K03928 - - - - ko00000,ko01000 - - - Acyltransferase,Hydrolase_4 k59_1361845_1 1237149.C900_01738 3.31e-46 159.0 COG0436@1|root,COG0436@2|Bacteria,4NES3@976|Bacteroidetes,47MBR@768503|Cytophagia 976|Bacteroidetes E PFAM Aminotransferase class I and II ybdL - 2.6.1.88 ko:K14287 - - R08618 RC00006,RC00025 ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_1361845_2 643867.Ftrac_1583 1.43e-15 75.1 COG0388@1|root,COG0388@2|Bacteria,4NE37@976|Bacteroidetes,47JPF@768503|Cytophagia 976|Bacteroidetes S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase yafV - 3.5.1.3 ko:K13566 ko00250,map00250 - R00269,R00348 RC00010 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_107731_2 1048983.EL17_12260 8.26e-19 87.0 COG1197@1|root,COG1197@2|Bacteria,4NEPA@976|Bacteroidetes,47K49@768503|Cytophagia 976|Bacteroidetes L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1205935_1 305900.GV64_07400 5.78e-56 196.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XHXU@135619|Oceanospirillales 135619|Oceanospirillales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1152646_1 596154.Alide2_0319 5.03e-73 234.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,4ABEH@80864|Comamonadaceae 28216|Betaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_525922_2 1163398.AJJP01000139_gene3342 2.58e-43 156.0 COG0665@1|root,COG0665@2|Bacteria 2|Bacteria E tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity - - - - - - - - - - - - DAO k59_473411_1 42565.FP66_03985 1.64e-49 174.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1XI0Q@135619|Oceanospirillales 135619|Oceanospirillales P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_369402_1 450851.PHZ_c0574 8.44e-05 49.7 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2TR8J@28211|Alphaproteobacteria,2KFSW@204458|Caulobacterales 204458|Caulobacterales S Belongs to the GcvT family - - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_369402_2 1379270.AUXF01000004_gene3287 1.3e-20 92.0 COG0247@1|root,COG0247@2|Bacteria,1ZSTK@142182|Gemmatimonadetes 142182|Gemmatimonadetes C 4Fe-4S binding domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG k59_788941_1 1123320.KB889585_gene1872 2.35e-161 463.0 COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_996493_1 318167.Sfri_2190 1.95e-30 118.0 COG0189@1|root,COG0189@2|Bacteria,1MVDU@1224|Proteobacteria,1RR7D@1236|Gammaproteobacteria,2Q8R8@267890|Shewanellaceae 1236|Gammaproteobacteria HJ TIGRFAM alpha-L-glutamate ligase-like protein PA1766 - - - - - - - - - - - ATPgrasp_ST k59_996493_2 1280946.HY29_06970 3.28e-08 56.2 COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,2UIDH@28211|Alphaproteobacteria,43Z9Q@69657|Hyphomonadaceae 28211|Alphaproteobacteria E 7 transmembrane helices usually fused to an inactive transglutaminase - - - - - - - - - - - - 7TM_transglut,Transglut_i_TM k59_1049188_2 272134.KB731326_gene296 5.66e-16 77.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_25,Methyltransf_31,Ubie_methyltran k59_1414631_1 933262.AXAM01000006_gene1855 7.1e-34 119.0 COG1030@1|root,COG1030@2|Bacteria 2|Bacteria - - nfeD - - ko:K07403 - - - - ko00000 - - - CLP_protease,NfeD k59_1414631_2 1121406.JAEX01000010_gene1391 1.45e-10 60.8 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WISZ@28221|Deltaproteobacteria,2M97G@213115|Desulfovibrionales 28221|Deltaproteobacteria O PFAM Band 7 protein - - - - - - - - - - - - Band_7 k59_474309_1 1434325.AZQN01000002_gene1206 6.3e-30 122.0 COG3748@1|root,COG3748@2|Bacteria,4PN1Z@976|Bacteroidetes,47YSJ@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF1549) - - - - - - - - - - - - Laminin_G_3,PSCyt1,PSCyt2,PSD1 k59_422341_1 67281.JNZZ01000008_gene5775 1.29e-07 58.9 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,41BN0@629295|Streptomyces griseus group 201174|Actinobacteria C Cytochrome P450 - - - - - - - - - - - - p450 k59_944301_1 445686.E3SKU6_9CAUD 7.56e-91 308.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_1623751_1 1415778.JQMM01000001_gene634 3.11e-79 243.0 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1J4ME@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_370133_1 1404245.CGLY_03010 1.46e-14 80.9 COG2807@1|root,COG2807@2|Bacteria 2|Bacteria P transmembrane transport - - - - - - - - - - - - MFS_1 k59_526677_1 1160718.SU9_16052 1.6e-28 114.0 COG0113@1|root,COG0113@2|Bacteria,2GJJ0@201174|Actinobacteria 201174|Actinobacteria H Belongs to the ALAD family hemB GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_526677_2 1232410.KI421416_gene2645 4.49e-23 89.4 2EE6A@1|root,3380W@2|Bacteria,1NCBW@1224|Proteobacteria,42V9R@68525|delta/epsilon subdivisions,2WSI3@28221|Deltaproteobacteria,43VQV@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_57710_1 1123399.AQVE01000020_gene1688 6.03e-22 94.4 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,45ZQP@72273|Thiotrichales 72273|Thiotrichales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_57710_2 589865.DaAHT2_1291 2.89e-20 89.7 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,42NRV@68525|delta/epsilon subdivisions,2WIXX@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_1206977_1 1049564.TevJSym_ax00450 1.71e-51 175.0 COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,1RN0S@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_944309_1 1121861.KB899941_gene3863 3.59e-14 72.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria,2JPJW@204441|Rhodospirillales 204441|Rhodospirillales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_474328_2 1452718.JBOY01000004_gene3094 6.59e-17 83.2 2ED7U@1|root,3374E@2|Bacteria,1NG30@1224|Proteobacteria,1SDDX@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_213361_1 1137799.GZ78_22495 1.32e-29 121.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1XH7W@135619|Oceanospirillales 135619|Oceanospirillales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_213361_2 717773.Thicy_1185 2.75e-10 58.9 COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,1S3UD@1236|Gammaproteobacteria,460Q1@72273|Thiotrichales 72273|Thiotrichales E D,D-heptose 1,7-bisphosphate phosphatase - - 3.1.3.82,3.1.3.83 ko:K03273 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_like k59_370136_1 1380391.JIAS01000012_gene4506 9.83e-67 214.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2TSVS@28211|Alphaproteobacteria,2JQE0@204441|Rhodospirillales 204441|Rhodospirillales S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_370136_2 1502851.FG93_04399 9.62e-11 62.8 COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2UBYM@28211|Alphaproteobacteria,3JY1I@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Thioesterase superfamily ybgC - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT k59_265686_1 330214.NIDE1300 2.92e-85 252.0 COG0080@1|root,COG0080@2|Bacteria,3J0K2@40117|Nitrospirae 40117|Nitrospirae J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_1259107_1 1237149.C900_04913 2.08e-31 115.0 COG0639@1|root,COG0639@2|Bacteria,4NEQW@976|Bacteroidetes,47SZE@768503|Cytophagia 976|Bacteroidetes T Calcineurin-like phosphoesterase - - 3.1.3.16 ko:K07313 - - - - ko00000,ko01000 - - - Metallophos k59_735704_1 1150469.RSPPHO_01062 1.11e-51 173.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2TRSG@28211|Alphaproteobacteria,2JPAY@204441|Rhodospirillales 204441|Rhodospirillales E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1,His_biosynth k59_735704_2 644282.Deba_3179 3.86e-14 76.6 2E6CS@1|root,3310E@2|Bacteria,1N2FR@1224|Proteobacteria,42UY2@68525|delta/epsilon subdivisions,2WPMU@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_735704_3 1469245.JFBG01000040_gene1734 7.17e-37 132.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,1WWF1@135613|Chromatiales 135613|Chromatiales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_944313_1 1121859.KB890739_gene2703 1.16e-51 181.0 COG3119@1|root,COG3119@2|Bacteria,4NGX1@976|Bacteroidetes,47K2H@768503|Cytophagia 976|Bacteroidetes P Sulfatase - - - - - - - - - - - - DUF4976,Sulfatase k59_108502_1 1298867.AUES01000001_gene1649 5.62e-32 128.0 COG0421@1|root,COG0421@2|Bacteria,1PD54@1224|Proteobacteria,2V9CT@28211|Alphaproteobacteria,3JYAK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Spermine/spermidine synthase domain - - - - - - - - - - - - Spermine_synth k59_1623772_1 1030157.AFMP01000009_gene3644 2.42e-27 114.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TVSC@28211|Alphaproteobacteria,2K306@204457|Sphingomonadales 204457|Sphingomonadales C Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_735711_1 543728.Vapar_4086 1.49e-102 308.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VM5X@28216|Betaproteobacteria,4ABXX@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM L-carnitine dehydratase bile acid-inducible protein F - - 2.8.3.19 ko:K18702 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_788996_1 485916.Dtox_3626 7.72e-06 53.1 COG0860@1|root,COG0860@2|Bacteria,1UYPW@1239|Firmicutes,24BHU@186801|Clostridia,260BF@186807|Peptococcaceae 186801|Clostridia M Cell Wall - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,CW_binding_2,Cu_amine_oxidN1,SH3_3 k59_1259121_2 237368.SCABRO_01762 8.83e-109 331.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,2J0WT@203682|Planctomycetes 203682|Planctomycetes C Conserved carboxylase domain - - - - - - - - - - - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_57752_1 545264.KB898746_gene741 3.13e-25 99.4 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,1WY5Q@135613|Chromatiales 135613|Chromatiales S Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate - - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 k59_159780_1 926550.CLDAP_31760 3.78e-91 273.0 COG0313@1|root,COG0313@2|Bacteria,2G5VQ@200795|Chloroflexi 200795|Chloroflexi H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_944333_1 93612.XP_008027345.1 7.65e-38 144.0 COG0654@1|root,KOG3855@2759|Eukaryota,39WHW@33154|Opisthokonta,3NZFF@4751|Fungi,3QP1R@4890|Ascomycota 4751|Fungi CH fad binding domain-containing protein - - - - - - - - - - - - FAD_binding_3 k59_108520_2 745014.OMB55_00008950 2.95e-35 131.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1J4KU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1990928 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - iECs_1301.ECs0077,iYL1228.KPN_00079,iZ_1308.Z0082 Iso_dh k59_684553_1 1390370.O203_07765 2.34e-13 70.5 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1T9I0@1236|Gammaproteobacteria,1YCZN@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Sodium:solute symporter family - - - - - - - - - - - - SSF k59_159781_1 766499.C357_06634 5.05e-11 63.9 COG1171@1|root,COG1171@2|Bacteria,1QVNS@1224|Proteobacteria,2TUHW@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Diaminopropionate ammonia-lyase dpaL GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008838,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575 4.3.1.15 ko:K01751 - - - - ko00000,ko01000 - - - PALP k59_159781_2 1380394.JADL01000010_gene4336 3.69e-185 526.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JPPW@204441|Rhodospirillales 204441|Rhodospirillales C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_896517_1 330214.NIDE2826 1.25e-73 233.0 COG1459@1|root,COG1459@2|Bacteria,3J0HZ@40117|Nitrospirae 40117|Nitrospirae U Type II secretion system (T2SS), protein F - - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF k59_217206_1 1129794.C427_3800 7.15e-35 123.0 COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,1S8VH@1236|Gammaproteobacteria,467ZY@72275|Alteromonadaceae 1236|Gammaproteobacteria L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hupB GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006323,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010556,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051276,GO:0060255,GO:0065007,GO:0071103,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2001141 - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_1472159_1 713586.KB900536_gene37 7.51e-38 146.0 COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria 1224|Proteobacteria L double-strand break repair protein AddB addB - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1 k59_374001_1 1121272.KB903249_gene2267 5.94e-95 300.0 28IUR@1|root,2Z8TE@2|Bacteria,2I9P5@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_794098_1 7739.XP_002608780.1 2.71e-10 61.2 COG5275@1|root,KOG1968@2759|Eukaryota,38C6S@33154|Opisthokonta,3BBFZ@33208|Metazoa,3CY2K@33213|Bilateria,486Y0@7711|Chordata 33208|Metazoa L protein-DNA loading ATPase activity RFC1 GO:0000122,GO:0000166,GO:0000723,GO:0000731,GO:0000902,GO:0000904,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005657,GO:0005663,GO:0005694,GO:0005730,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006278,GO:0006281,GO:0006283,GO:0006289,GO:0006296,GO:0006297,GO:0006301,GO:0006355,GO:0006357,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007004,GO:0007049,GO:0007275,GO:0007399,GO:0008047,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009653,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010833,GO:0016043,GO:0016358,GO:0017076,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019725,GO:0019904,GO:0019985,GO:0022008,GO:0022402,GO:0030030,GO:0030154,GO:0030182,GO:0030234,GO:0030554,GO:0031175,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031974,GO:0031981,GO:0032200,GO:0032201,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032989,GO:0032990,GO:0032991,GO:0033260,GO:0033554,GO:0033683,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042276,GO:0042592,GO:0042769,GO:0043085,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043565,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044464,GO:0044786,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048468,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048813,GO:0048856,GO:0048858,GO:0048869,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051276,GO:0051606,GO:0051716,GO:0060249,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070987,GO:0071704,GO:0071840,GO:0071897,GO:0080090,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0098772,GO:0120036,GO:0120039,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K10754 ko03030,ko03420,ko03430,map03030,map03420,map03430 M00289,M00295 - - ko00000,ko00001,ko00002,ko03032,ko03400 - - - AAA,BRCT,RFC1 k59_794098_3 1195236.CTER_4199 7.39e-28 111.0 COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,247SC@186801|Clostridia,3WGPU@541000|Ruminococcaceae 186801|Clostridia J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family yacO - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_162929_1 713586.KB900536_gene2469 2.56e-99 303.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1WWYV@135613|Chromatiales 135613|Chromatiales NU Type II secretion system - - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_217924_1 224324.aq_1283 0.000485 43.5 COG0071@1|root,COG0071@2|Bacteria,2G4AZ@200783|Aquificae 200783|Aquificae O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_63697_1 1123288.SOV_2c02220 6.42e-26 112.0 COG0855@1|root,COG0855@2|Bacteria,1TNZM@1239|Firmicutes,4H34H@909932|Negativicutes 909932|Negativicutes H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_1157824_1 1120956.JHZK01000013_gene2574 5.32e-99 307.0 COG2271@1|root,COG2271@2|Bacteria,1QXP5@1224|Proteobacteria,2TXP1@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_374771_1 314278.NB231_13346 1.93e-15 81.3 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1000769_1 572477.Alvin_0496 1.87e-28 110.0 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,1WWEI@135613|Chromatiales 135613|Chromatiales H PFAM UBA THIF-type NAD FAD binding - - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_897199_1 1041147.AUFB01000007_gene523 2.06e-59 208.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,4B9S2@82115|Rhizobiaceae 28211|Alphaproteobacteria M Belongs to the peptidase S1C family degP GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_1575510_1 317655.Sala_2314 1.94e-81 255.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,2K0AI@204457|Sphingomonadales 204457|Sphingomonadales S amidohydrolase - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_112779_1 1185766.DL1_20235 2.35e-25 105.0 COG2103@1|root,COG2103@2|Bacteria,1MVDR@1224|Proteobacteria,2TTCF@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling murQ - 4.2.1.126 ko:K07106 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - - SIS,SIS_2 k59_112779_2 113395.AXAI01000006_gene1574 1.78e-06 49.7 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,3JTCM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_1367159_2 1267535.KB906767_gene769 2.33e-09 58.2 COG1109@1|root,COG1109@2|Bacteria,3Y36F@57723|Acidobacteria,2JHU9@204432|Acidobacteriia 204432|Acidobacteriia G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_531166_2 1002809.SSIL_2408 1.73e-56 194.0 COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,4H9VR@91061|Bacilli,26DUZ@186818|Planococcaceae 91061|Bacilli E COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1053850_2 1121918.ARWE01000001_gene3526 4.63e-22 90.1 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,42RI1@68525|delta/epsilon subdivisions,2WNBG@28221|Deltaproteobacteria,43UQI@69541|Desulfuromonadales 28221|Deltaproteobacteria O Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ppiA - 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_740096_1 240015.ACP_2625 9.18e-69 224.0 COG0312@1|root,COG0312@2|Bacteria,3Y39N@57723|Acidobacteria,2JIHC@204432|Acidobacteriia 204432|Acidobacteriia S PFAM peptidase U62 modulator of DNA gyrase - - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_844817_1 234831.PSM_A1921 1.32e-24 110.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MUQV@1224|Proteobacteria,1RN0Q@1236|Gammaproteobacteria,2PZD7@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,LapD_MoxY_N k59_948646_1 1280949.HAD_06585 3.74e-11 69.3 COG1629@1|root,COG4771@2|Bacteria,1R0WC@1224|Proteobacteria,2U1A6@28211|Alphaproteobacteria,43WF4@69657|Hyphomonadaceae 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - OMP_b-brl_3,Plug,TonB_dep_Rec k59_1106172_1 1408428.JNJP01000019_gene1664 5.4e-58 194.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MG3@68525|delta/epsilon subdivisions,2WKC7@28221|Deltaproteobacteria,2M940@213115|Desulfovibrionales 28221|Deltaproteobacteria Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_323063_1 330214.NIDE3560 3.89e-104 313.0 COG1894@1|root,COG1894@2|Bacteria,3J0WA@40117|Nitrospirae 40117|Nitrospirae C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region - - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_1265032_1 436308.Nmar_0665 2.72e-17 85.1 COG3119@1|root,arCOG02785@2157|Archaea,41T3Q@651137|Thaumarchaeota 651137|Thaumarchaeota P COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - - k59_1106173_2 402880.MmarC5_0026 2.01e-20 89.0 COG2085@1|root,arCOG00457@2157|Archaea,2XUD2@28890|Euryarchaeota,23QAN@183939|Methanococci 183939|Methanococci C PFAM NADP oxidoreductase coenzyme F420-dependent - GO:0000041,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006826,GO:0008150,GO:0008152,GO:0008823,GO:0015677,GO:0015682,GO:0016020,GO:0016021,GO:0016491,GO:0016722,GO:0016723,GO:0030001,GO:0031224,GO:0031226,GO:0033216,GO:0034220,GO:0034755,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0052851,GO:0055085,GO:0055114,GO:0071944,GO:0072512,GO:0097286,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098706,GO:0098711,GO:0098739,GO:0099587 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored k59_1520889_1 472759.Nhal_1430 1.04e-156 451.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1WWNU@135613|Chromatiales 135613|Chromatiales E PFAM Aminotransferase class-III - - 2.6.1.13 ko:K00819 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R00667 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_1265042_1 379066.GAU_2231 1.14e-43 159.0 COG4585@1|root,COG4585@2|Bacteria,1ZSM2@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Histidine kinase - - - - - - - - - - - - HisKA_3 k59_689913_1 1402135.SUH3_06270 2.86e-24 98.6 COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,2TSAI@28211|Alphaproteobacteria,3ZVQ8@60136|Sulfitobacter 28211|Alphaproteobacteria O Cytochrome C biogenesis protein transmembrane region ccdA - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD k59_689913_2 1123020.AUIE01000010_gene1236 2.13e-57 185.0 COG0526@1|root,COG0526@2|Bacteria,1RJUZ@1224|Proteobacteria,1S6Y0@1236|Gammaproteobacteria 1236|Gammaproteobacteria CO PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA,LGT,Redoxin k59_531191_1 1121918.ARWE01000001_gene2794 2.32e-63 212.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2WJP6@28221|Deltaproteobacteria,43S1W@69541|Desulfuromonadales 28221|Deltaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - iAF987.Gmet_1487 GATase_6,SIS k59_63773_1 3055.EDP01398 4.08e-17 80.9 COG0082@1|root,KOG4492@2759|Eukaryota,37JJX@33090|Viridiplantae,34GW3@3041|Chlorophyta 3041|Chlorophyta E Chorismate synthase - - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_63773_2 1367847.JCM7686_0540 2.71e-15 72.0 COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2UF4X@28211|Alphaproteobacteria,2PXGH@265|Paracoccus 28211|Alphaproteobacteria S YCII-related domain yciI GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09780 - - - - ko00000 - - - YCII k59_1053880_1 65393.PCC7424_1335 2.6e-78 251.0 COG1506@1|root,COG1506@2|Bacteria,1G200@1117|Cyanobacteria,3KFR1@43988|Cyanothece 1117|Cyanobacteria E PFAM peptidase S9 prolyl oligopeptidase active site domain protein dap2 - - - - - - - - - - - PD40,Peptidase_S9 k59_112825_1 1163408.UU9_02873 1.12e-35 125.0 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1X6WU@135614|Xanthomonadales 135614|Xanthomonadales P protein affecting Mg2 Co2 transport apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_112825_2 1196083.SALWKB12_1867 4.24e-13 69.7 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,2VHV6@28216|Betaproteobacteria,2KPG2@206351|Neisseriales 206351|Neisseriales T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH - 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - - Metallophos k59_112827_1 420324.KI912084_gene7403 6.33e-22 99.4 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,1JSYN@119045|Methylobacteriaceae 28211|Alphaproteobacteria T PFAM Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - Guanylate_cyc,HEAT_2,Rhodanese,TPR_16,TPR_19,TPR_8,TolB_N k59_897255_1 309801.trd_A0311 0.000231 48.5 COG0517@1|root,COG0589@1|root,COG0517@2|Bacteria,COG0589@2|Bacteria,2GBED@200795|Chloroflexi,27Z4M@189775|Thermomicrobia 189775|Thermomicrobia T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS,Usp k59_1000836_2 502025.Hoch_4684 1.39e-53 190.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,42Q75@68525|delta/epsilon subdivisions,2WMDY@28221|Deltaproteobacteria,2YU11@29|Myxococcales 28221|Deltaproteobacteria L DEAD DEAH box - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_795154_1 472759.Nhal_3898 1.15e-118 348.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,1WW4G@135613|Chromatiales 135613|Chromatiales P PFAM CBS domain - - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_1628501_1 198628.Dda3937_00179 6.59e-34 132.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,2JC9S@204037|Dickeya 1236|Gammaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945 BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_1628501_2 1121448.DGI_0840 5.61e-20 92.0 COG0477@1|root,COG2814@2|Bacteria,1PG3D@1224|Proteobacteria,42S62@68525|delta/epsilon subdivisions,2WNYR@28221|Deltaproteobacteria,2MGPZ@213115|Desulfovibrionales 28221|Deltaproteobacteria EGP PFAM major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_1,Sugar_tr k59_1106214_1 1452718.JBOY01000053_gene2234 6.09e-88 266.0 COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,1RMHS@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2500,iBWG_1329.BWG_2264,iECDH10B_1368.ECDH10B_2666,iECDH1ME8569_1439.ECDH1ME8569_2426,iEcDH1_1363.EcDH1_1169,iJO1366.b2500,iJR904.b2500,iY75_1357.Y75_RS13050 Formyl_trans_N k59_1212977_1 395019.Bmul_0839 1e-40 152.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2VK1S@28216|Betaproteobacteria,1K1E7@119060|Burkholderiaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily btuC - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_1367210_1 983917.RGE_12440 7.06e-09 61.6 COG3137@1|root,COG3137@2|Bacteria,1N6XJ@1224|Proteobacteria,2VWDA@28216|Betaproteobacteria,1KNYK@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Protein of unknown function, DUF481 - - - ko:K07283 - - - - ko00000 - - - DUF481 k59_795165_1 247639.MGP2080_10393 2.5e-63 208.0 2DBBP@1|root,2Z88Z@2|Bacteria,1R3B4@1224|Proteobacteria,1RSHG@1236|Gammaproteobacteria,1J5IE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_112838_1 1121935.AQXX01000144_gene4417 5.02e-93 280.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,1RQN1@1236|Gammaproteobacteria,1XHGV@135619|Oceanospirillales 135619|Oceanospirillales S C4-dicarboxylate ABC transporter substrate-binding protein - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_583459_1 1123073.KB899241_gene3157 4.02e-54 183.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1X345@135614|Xanthomonadales 135614|Xanthomonadales U General secretion pathway protein xpsF GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_1314562_1 1444712.BN1013_00926 3.73e-14 69.3 COG0105@1|root,COG0105@2|Bacteria 2|Bacteria F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_795178_1 1307759.JOMJ01000003_gene1979 1.19e-72 232.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42NVU@68525|delta/epsilon subdivisions,2WMH6@28221|Deltaproteobacteria,2MARK@213115|Desulfovibrionales 28221|Deltaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.111,5.4.3.8 ko:K01845,ko:K07257,ko:K21585 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272,R11607 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3,CTP_transf_3 k59_1000856_1 511051.CSE_08010 3.37e-34 140.0 COG4191@1|root,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_1000856_2 1322246.BN4_12026 2.13e-19 89.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2M91Y@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM sigma-54 factor interaction domain-containing protein ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1628522_1 1123368.AUIS01000003_gene1764 2.26e-144 422.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,2NCBG@225057|Acidithiobacillales 1236|Gammaproteobacteria NU Type II secretion system (T2SS), protein E, N-terminal domain gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE k59_531234_1 394.NGR_c03330 3.16e-90 284.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2TRND@28211|Alphaproteobacteria,4BA30@82115|Rhizobiaceae 28211|Alphaproteobacteria I Acyl-coenzyme A synthetases AMP-(fatty) acid ligases acsA1 - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_323131_1 930169.B5T_01008 1.3e-82 257.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1XHUY@135619|Oceanospirillales 135619|Oceanospirillales F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_374871_4 1493510.A0A0E3HB31_9CAUD 4.69e-10 56.2 4QEY6@10239|Viruses,4QPIW@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_479406_1 237609.PSAKL28_22590 1.79e-12 63.9 COG3791@1|root,COG3791@2|Bacteria,1RCYS@1224|Proteobacteria,1S3X0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_1473169_1 545694.TREPR_0340 6.91e-57 196.0 COG0367@1|root,COG0367@2|Bacteria,2J6Q5@203691|Spirochaetes 203691|Spirochaetes E TIGRFAM asparagine synthase (glutamine-hydrolyzing) - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_270381_1 1183438.GKIL_3636 2.76e-11 63.2 COG0546@1|root,COG0546@2|Bacteria,1GQGX@1117|Cyanobacteria 1117|Cyanobacteria S HAD superfamily - - - ko:K07025 - - - - ko00000 - - - HAD_2,Hydrolase k59_270381_2 6211.A0A087VZH9 2.15e-26 104.0 COG0693@1|root,KOG2764@2759|Eukaryota,3A1YC@33154|Opisthokonta,3BQJG@33208|Metazoa,3CY3Z@33213|Bilateria 33208|Metazoa V Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair djr-1.2 GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006066,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009058,GO:0009438,GO:0009441,GO:0009636,GO:0009987,GO:0010033,GO:0010941,GO:0016053,GO:0017144,GO:0019249,GO:0019752,GO:0032787,GO:0034308,GO:0034309,GO:0036471,GO:0042180,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046165,GO:0046295,GO:0046394,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051595,GO:0051716,GO:0060548,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0072330,GO:0097238,GO:0110096,GO:1901214,GO:1901215,GO:1901576,GO:1901615,GO:1901617,GO:1901654,GO:1901655,GO:1901700,GO:1901701,GO:1903189 3.5.1.124 ko:K05687 ko05012,map05012 - - - ko00000,ko00001,ko01000,ko01002,ko04147 - - - DJ-1_PfpI k59_63825_1 1469245.JFBG01000014_gene2025 2.55e-90 273.0 COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,1S9CF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_1213006_1 1415778.JQMM01000001_gene904 7.89e-31 115.0 COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,1S8XU@1236|Gammaproteobacteria,1J72N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG3030 Protein affecting phage T7 exclusion by the F plasmid fxsA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944 - ko:K07113 - - - - ko00000 - - - FxsA k59_1213006_2 227377.CBU_1719 1.59e-26 99.8 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,1JEPU@118969|Legionellales 118969|Legionellales O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_1265122_1 377629.TERTU_3126 6.83e-75 229.0 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria,2PN0Z@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria T helix_turn_helix, cAMP Regulatory protein crp GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007584,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019222,GO:0019438,GO:0030551,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0032553,GO:0032555,GO:0032561,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0035438,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045013,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045990,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0061984,GO:0061985,GO:0065007,GO:0070887,GO:0071496,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140110,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - Crp,cNMP_binding k59_638376_1 1394178.AWOO02000011_gene4014 1.63e-94 292.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_71747_1 330214.NIDE0444 4.39e-42 145.0 COG2519@1|root,COG2519@2|Bacteria,3J0PT@40117|Nitrospirae 40117|Nitrospirae J Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA - - 2.1.1.219,2.1.1.220 ko:K07442 - - - - ko00000,ko01000,ko03016 - - - GCD14,GCD14_N k59_1635285_1 999541.bgla_2g21200 1.66e-51 188.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,1K0BR@119060|Burkholderiaceae 28216|Betaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1427521_1 330214.NIDE1236 1.69e-76 237.0 COG0501@1|root,COG0501@2|Bacteria,3J0QG@40117|Nitrospirae 40117|Nitrospirae O Peptidase family M48 htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_276587_1 1177179.A11A3_13340 4.31e-42 152.0 COG3687@1|root,COG3687@2|Bacteria,1RBP4@1224|Proteobacteria,1RZJF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Metal-dependent hydrolase - - - ko:K07044 - - - - ko00000 - - - Metal_hydrol k59_1112323_1 999141.GME_03722 2.79e-33 124.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1XIQQ@135619|Oceanospirillales 135619|Oceanospirillales M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_1112323_2 1323663.AROI01000006_gene3006 4.06e-16 80.5 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097 Mur_ligase_C,Mur_ligase_M k59_850924_1 406818.XBJ1_4129 0.000114 52.0 COG3264@1|root,COG4942@1|root,COG3264@2|Bacteria,COG4942@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M mechanosensitive ion channel yjeP - - ko:K05802,ko:K22051 - - - - ko00000,ko02000 1.A.23.1.1,1.A.23.1.2,1.A.23.1.3 - - MS_channel,MscS_TM,MscS_porin k59_803502_1 936455.KI421499_gene579 4.12e-58 191.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TUWV@28211|Alphaproteobacteria,3JTKA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Pyridoxal-phosphate dependent enzyme MA20_02330 - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_803502_2 331869.BAL199_19503 4.64e-14 69.7 COG2872@1|root,COG2872@2|Bacteria,1MY0P@1224|Proteobacteria,2TRRW@28211|Alphaproteobacteria,4BRHA@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Threonyl and Alanyl tRNA synthetase second additional domain alaS2 GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K07050 - - - - ko00000,ko01000,ko03016 - - - tRNA-synt_2c,tRNA_SAD k59_646429_1 237368.SCABRO_01997 1.34e-80 257.0 COG1007@1|root,COG1007@2|Bacteria,2IXC6@203682|Planctomycetes 203682|Planctomycetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1427528_1 330214.NIDE1034 2.29e-150 433.0 COG3842@1|root,COG3842@2|Bacteria 2|Bacteria P ATPase activity potA - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 k59_1007255_2 1123355.JHYO01000029_gene3726 7.33e-16 77.4 COG0591@1|root,COG0591@2|Bacteria,1MWX6@1224|Proteobacteria,2UA3I@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1007256_1 981085.XP_010096072.1 1.17e-42 157.0 COG0124@1|root,KOG1936@2759|Eukaryota,37QT9@33090|Viridiplantae,3GGEC@35493|Streptophyta,4JG1D@91835|fabids 35493|Streptophyta J Histidine--tRNA - GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009536,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_646437_1 96561.Dole_2244 5.91e-49 161.0 arCOG05253@1|root,31CTK@2|Bacteria,1RIYS@1224|Proteobacteria,42T7T@68525|delta/epsilon subdivisions,2WP9R@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1635310_1 1197130.BAFM01000011_gene2067 1.5e-09 62.4 COG0778@1|root,arCOG00298@2157|Archaea,2XV2F@28890|Euryarchaeota,23UUN@183963|Halobacteria 183963|Halobacteria Q SagB-type dehydrogenase - - - - - - - - - - - - Nitroreductase k59_1273222_1 436308.Nmar_0550 3.01e-88 266.0 COG0169@1|root,arCOG01033@2157|Archaea,41S6G@651137|Thaumarchaeota 651137|Thaumarchaeota E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_169815_1 911045.PSE_2335 3.17e-37 137.0 COG0665@1|root,COG0665@2|Bacteria,1MXD1@1224|Proteobacteria,2TTDG@28211|Alphaproteobacteria 28211|Alphaproteobacteria E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_169815_2 5017.XP_007716385.1 7.38e-30 122.0 COG0160@1|root,KOG1404@2759|Eukaryota,38DZP@33154|Opisthokonta,3NTX4@4751|Fungi,3QQEP@4890|Ascomycota,1ZYIT@147541|Dothideomycetes 4751|Fungi E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008144,GO:0008453,GO:0008483,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - - - - - - - - - - Aminotran_3 k59_954928_2 95619.PM1_0217380 2.57e-90 280.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_3323,iPC815.YPO3377 CTP_synth_N,GATase k59_1373266_1 713587.THITH_07195 1.1e-66 217.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WW29@135613|Chromatiales 135613|Chromatiales S PFAM Uncharacterised protein family UPF0027 rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_1060237_1 1249480.B649_10415 1.03e-17 83.2 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N1I@68525|delta/epsilon subdivisions,2YMA0@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome ccpA - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_1060237_2 671143.DAMO_2385 7.84e-49 168.0 COG0489@1|root,COG0489@2|Bacteria,2NNX1@2323|unclassified Bacteria 2|Bacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_71787_1 1123072.AUDH01000002_gene2452 4.55e-74 252.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JPRP@204441|Rhodospirillales 204441|Rhodospirillales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_954935_1 47716.JOFH01000013_gene5379 0.000456 47.8 COG0477@1|root,COG2814@2|Bacteria,2GM2G@201174|Actinobacteria 201174|Actinobacteria EGP Major facilitator Superfamily - - - ko:K05548 - - - - ko00000,ko02000 2.A.1.15 - - MFS_1,MFS_4,Sugar_tr k59_1060241_1 981369.JQMJ01000003_gene7586 1.34e-42 152.0 COG1545@1|root,COG2030@1|root,COG1545@2|Bacteria,COG2030@2|Bacteria,2GM2A@201174|Actinobacteria,2NEHA@228398|Streptacidiphilus 201174|Actinobacteria I Rubredoxin-like zinc ribbon domain (DUF35_N) - - - - - - - - - - - - DUF35_N,MaoC_dehydrat_N,MaoC_dehydratas,OB_aCoA_assoc k59_169829_1 290397.Adeh_3015 2.28e-61 215.0 COG1038@1|root,COG1038@2|Bacteria,1NW9R@1224|Proteobacteria,43BKE@68525|delta/epsilon subdivisions,2X6YE@28221|Deltaproteobacteria,2YYQ8@29|Myxococcales 28221|Deltaproteobacteria C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second pyc - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA k59_487662_1 404589.Anae109_0518 4.41e-64 217.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2WJ51@28221|Deltaproteobacteria,2YTV0@29|Myxococcales 28221|Deltaproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_71801_1 1254432.SCE1572_33050 6.46e-36 137.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WKYA@28221|Deltaproteobacteria,2YU1C@29|Myxococcales 28221|Deltaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455,ko:K11745,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.1,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N k59_537228_1 1260251.SPISAL_00380 5.8e-46 164.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1WXGA@135613|Chromatiales 135613|Chromatiales C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) - - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1635353_2 1415779.JOMH01000001_gene2132 2.69e-30 122.0 COG4638@1|root,COG4638@2|Bacteria,1N3CA@1224|Proteobacteria,1S0V7@1236|Gammaproteobacteria,1X4YE@135614|Xanthomonadales 135614|Xanthomonadales P Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_1007294_1 1116472.MGMO_223c00120 9.56e-103 321.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1XEQA@135618|Methylococcales 135618|Methylococcales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1007301_1 180281.CPCC7001_1276 1.88e-15 71.2 2BXN1@1|root,344QZ@2|Bacteria,1GMAG@1117|Cyanobacteria,22SYC@167375|Cyanobium 1117|Cyanobacteria S CP12 - - - - - - - - - - - - CP12 k59_1525034_1 748280.NH8B_3633 1.89e-21 89.4 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VSPR@28216|Betaproteobacteria 28216|Betaproteobacteria C cytochrome nosC - - - - - - - - - - - Cytochrome_CBB3 k59_1525034_2 1238190.AMQY01000018_gene1387 2.83e-07 50.8 COG3094@1|root,COG3094@2|Bacteria,1MZN6@1224|Proteobacteria,1S70H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Invasion gene expression up-regulator SirB - - - - - - - - - - - - SirB k59_803564_1 631362.Thi970DRAFT_00912 1.67e-21 92.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales 135613|Chromatiales K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_803564_2 1094715.CM001373_gene2433 5.79e-20 88.6 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1JDMY@118969|Legionellales 118969|Legionellales O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_169855_1 436308.Nmar_0053 8.49e-98 295.0 COG1679@1|root,arCOG04278@2157|Archaea,41SBC@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF521) - - - ko:K09123 - - - - ko00000 - - - DUF521 k59_803571_1 1169152.AXVD01000007_gene1828 6.79e-100 298.0 COG2230@1|root,COG2230@2|Bacteria 2|Bacteria M cyclopropane-fatty-acyl-phospholipid synthase - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0032259,GO:0044237,GO:0044249 2.1.1.254,2.1.1.295,2.1.1.79,2.7.11.1 ko:K00574,ko:K07154,ko:K14369,ko:K15257,ko:K18534 ko00130,ko00522,ko01100,ko01110,ko01130,map00130,map00522,map01100,map01110,map01130 M00112,M00774 R05520,R05532,R07501,R10709,R10710 RC00003,RC01324,RC01662 ko00000,ko00001,ko00002,ko01000,ko01001,ko01008,ko02048,ko03016 - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_589682_1 1004785.AMBLS11_14025 6.42e-40 145.0 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,464U9@72275|Alteromonadaceae 1236|Gammaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0042802,GO:0043093,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_589682_2 1260251.SPISAL_06820 2.06e-56 186.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1WW8T@135613|Chromatiales 135613|Chromatiales M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_1635378_1 404380.Gbem_3647 1.47e-27 118.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,43T20@69541|Desulfuromonadales 28221|Deltaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_746254_1 426117.M446_1369 2e-35 136.0 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,2U1N0@28211|Alphaproteobacteria,1JRBF@119045|Methylobacteriaceae 28211|Alphaproteobacteria C ATP ADP translocase - - - ko:K03301 - - - - ko00000 2.A.12 - - MFS_1,TLC k59_903430_2 1303518.CCALI_00872 6.24e-06 48.9 COG1600@1|root,COG1600@2|Bacteria 2|Bacteria C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) - - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_120016_1 690850.Desaf_2339 1.73e-65 224.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2WJ3E@28221|Deltaproteobacteria,2M9Q4@213115|Desulfovibrionales 28221|Deltaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iAF987.Gmet_2300 Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_1373304_1 1049564.TevJSym_ak00800 1.83e-25 97.4 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,1J6HN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG1544 Ribosome-associated protein Y (PSrp-1) yhbH GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_1373304_2 1117314.PCIT_17445 4.13e-32 119.0 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,1S668@1236|Gammaproteobacteria,2Q2EX@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria G COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) ptsN GO:0001932,GO:0001934,GO:0003674,GO:0003824,GO:0004857,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0008047,GO:0008150,GO:0008643,GO:0009401,GO:0009893,GO:0010033,GO:0010243,GO:0010562,GO:0010604,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0019207,GO:0019209,GO:0019220,GO:0019222,GO:0019887,GO:0022804,GO:0022857,GO:0022898,GO:0030234,GO:0030295,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032147,GO:0032268,GO:0032270,GO:0032409,GO:0032412,GO:0032879,GO:0033674,GO:0034219,GO:0034762,GO:0034765,GO:0042221,GO:0042325,GO:0042327,GO:0043085,GO:0043086,GO:0043269,GO:0043549,GO:0044092,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0045859,GO:0045860,GO:0045937,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051049,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051338,GO:0051347,GO:0055085,GO:0060255,GO:0065007,GO:0065009,GO:0071702,GO:0071944,GO:0080090,GO:0090563,GO:0098772,GO:1901698 - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_1162979_2 234267.Acid_0583 1.16e-14 73.2 COG3191@1|root,COG3191@2|Bacteria,3Y6EN@57723|Acidobacteria 57723|Acidobacteria EQ Peptidase family S58 - - - - - - - - - - - - Peptidase_S58 k59_954978_2 1114964.L485_22075 2.01e-61 202.0 COG0346@1|root,COG0346@2|Bacteria,1MVIQ@1224|Proteobacteria,2U460@28211|Alphaproteobacteria,2KD4J@204457|Sphingomonadales 204457|Sphingomonadales E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_1374136_2 502558.EGYY_09380 4.86e-22 95.1 COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4CUGW@84998|Coriobacteriia 84998|Coriobacteriia E DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_72977_1 645991.Sgly_1590 2.1e-61 196.0 COG1704@1|root,COG1704@2|Bacteria,1V3Z0@1239|Firmicutes,24IH4@186801|Clostridia,26236@186807|Peptococcaceae 186801|Clostridia S PFAM LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_488810_1 1049564.TevJSym_al00200 5.71e-140 412.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4,Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3 k59_647655_1 1121930.AQXG01000003_gene2586 6.1e-69 222.0 COG0282@1|root,COG0282@2|Bacteria,4NFI0@976|Bacteroidetes,1IPB9@117747|Sphingobacteriia 976|Bacteroidetes C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_1525644_1 215803.DB30_5881 1.42e-69 237.0 COG3391@1|root,COG3391@2|Bacteria,1R7E0@1224|Proteobacteria,42Z2U@68525|delta/epsilon subdivisions,2WTYD@28221|Deltaproteobacteria,2YX64@29|Myxococcales 28221|Deltaproteobacteria S Cytochrome D1 heme domain - - - - - - - - - - - - Cytochrom_D1 k59_1428713_1 748658.KB907313_gene2244 1.51e-165 484.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales 135613|Chromatiales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_590561_1 161156.JQKW01000006_gene1240 3.04e-82 257.0 COG1206@1|root,COG1206@2|Bacteria,2GH7N@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs trmFO - 2.1.1.74 ko:K04094 - - - - ko00000,ko01000,ko03016,ko03036 - - - GIDA k59_1320157_1 112098.XP_008614743.1 1.06e-58 207.0 COG0265@1|root,KOG1421@2759|Eukaryota 2759|Eukaryota O serine-type endopeptidase activity DEG7 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009314,GO:0009416,GO:0009507,GO:0009536,GO:0009628,GO:0009642,GO:0009644,GO:0009892,GO:0010109,GO:0010205,GO:0016787,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0042548,GO:0043155,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043467,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0071704,GO:0140096,GO:1901564,GO:1905156 - - - - - - - - - - PDZ_1,PDZ_2,Trypsin_2 k59_804696_1 448385.sce3153 1.29e-36 132.0 COG0670@1|root,COG0670@2|Bacteria,1R7VN@1224|Proteobacteria,43DVQ@68525|delta/epsilon subdivisions,2WZ04@28221|Deltaproteobacteria,2Z11K@29|Myxococcales 28221|Deltaproteobacteria S Belongs to the BI1 family - - - ko:K06890 - - - - ko00000 - - - Bax1-I k59_1113280_1 1047013.AQSP01000134_gene1354 1.6e-86 273.0 COG2382@1|root,COG2382@2|Bacteria 2|Bacteria P enterobactin catabolic process - - - - - - - - - - - - Esterase k59_590571_1 330214.NIDE3904 5.91e-77 242.0 COG0438@1|root,COG0438@2|Bacteria,3J0Z0@40117|Nitrospirae 40117|Nitrospirae M Glycosyl transferases group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 k59_170731_1 999141.GME_03402 3.97e-42 143.0 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,1XJQQ@135619|Oceanospirillales 135619|Oceanospirillales S Belongs to the UPF0234 family - - - ko:K09767 - - - - ko00000 - - - DUF520 k59_330197_1 754476.Q7A_1036 2.43e-07 50.4 COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,1S5B7@1236|Gammaproteobacteria,463KN@72273|Thiotrichales 72273|Thiotrichales S Las17-binding protein actin regulator - - - - - - - - - - - - Ysc84 k59_1636526_1 1347392.CCEZ01000009_gene2344 1.56e-20 94.4 COG0143@1|root,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,248AU@186801|Clostridia,36E2T@31979|Clostridiaceae 186801|Clostridia J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_121205_1 1380391.JIAS01000011_gene4883 4.21e-103 334.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,2JPDT@204441|Rhodospirillales 204441|Rhodospirillales L DEAD/H associated - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_904411_1 1132855.KB913035_gene1502 4.73e-20 87.0 COG1611@1|root,COG3350@1|root,COG1611@2|Bacteria,COG3350@2|Bacteria,1R8EU@1224|Proteobacteria 1224|Proteobacteria S YHS domain - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - YHS k59_747141_1 216595.PFLU_5069 2.06e-60 193.0 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1YM9M@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria K Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins iscR GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_747141_2 1304275.C41B8_17938 2.05e-47 163.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - 2.1.1.200 ko:K02533,ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_1428753_1 1052684.PPM_2439 4.12e-07 58.5 COG0524@1|root,COG1621@1|root,COG0524@2|Bacteria,COG1621@2|Bacteria,1TPGM@1239|Firmicutes,4IPNK@91061|Bacilli,2760Y@186822|Paenibacillaceae 91061|Bacilli G Glycosyl hydrolases family 32 C terminal sacC5 - 2.7.1.4,3.2.1.80 ko:K00847,ko:K03332 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R00879,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - Glyco_hydro_32C,Glyco_hydro_32N,PfkB k59_538126_1 1047013.AQSP01000044_gene248 1.5e-35 140.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - Sortilin-Vps10 k59_590593_1 207954.MED92_18238 1.76e-05 51.2 COG4726@1|root,COG4726@2|Bacteria,1N7KP@1224|Proteobacteria,1SCM5@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Pilus assembly protein PilX pilX - - ko:K02673 - - - - ko00000,ko02035,ko02044 - - - PilX,PilX_N k59_441578_1 344747.PM8797T_21393 6.96e-63 208.0 COG0644@1|root,COG0644@2|Bacteria,2IX1U@203682|Planctomycetes 203682|Planctomycetes C COG0644 Dehydrogenases (flavoproteins) - - - - - - - - - - - - Trp_halogenase k59_231278_1 671143.DAMO_0695 8.93e-37 136.0 COG0205@1|root,COG0205@2|Bacteria,2NNXU@2323|unclassified Bacteria 2|Bacteria G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135 2.7.1.11,2.7.1.90 ko:K00850,ko:K00895,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_813408_1 519989.ECTPHS_10124 3.47e-82 266.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales 135613|Chromatiales D DNA segregation ATPase FtsK SpoIIIE - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_284143_1 1286106.MPL1_12508 1.7e-147 424.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1RWC8@1236|Gammaproteobacteria,460AJ@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - LeuA_dimer,PALP k59_961979_2 330214.NIDE1676 2.41e-69 223.0 COG1066@1|root,COG1066@2|Bacteria,3J0BP@40117|Nitrospirae 40117|Nitrospirae O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - ATPase,ChlI,Lon_C k59_813414_1 1415780.JPOG01000001_gene123 2.41e-75 244.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,1X3DB@135614|Xanthomonadales 135614|Xanthomonadales L DNA helicase recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_128817_1 395494.Galf_1888 5.76e-86 263.0 28Q4X@1|root,2ZCN0@2|Bacteria,1RA2A@1224|Proteobacteria,2VX5Q@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1589367_1 1452718.JBOY01000063_gene2614 9.62e-89 291.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080 AIRS_C,GATase_5 k59_231288_1 351627.Csac_2528 1.13e-60 206.0 COG3934@1|root,COG3934@2|Bacteria,1V19K@1239|Firmicutes,24DHA@186801|Clostridia 186801|Clostridia G hydrolase family 5 - - 3.2.1.78 ko:K19355 ko00051,map00051 - R01332 RC00467 ko00000,ko00001,ko01000 - - - CBM_11,CBM_X2,Cellulase,Dockerin_1,fn3 k59_813423_1 502025.Hoch_2201 6.38e-44 145.0 COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2YV2V@29|Myxococcales 28221|Deltaproteobacteria C Rubrerythrin rbr GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - - - - - - - - - - Rubrerythrin k59_858560_1 392499.Swit_3319 7.95e-10 60.8 COG1960@1|root,COG1960@2|Bacteria,1PRJJ@1224|Proteobacteria,2UQWF@28211|Alphaproteobacteria,2K1XZ@204457|Sphingomonadales 204457|Sphingomonadales I Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_858560_2 994479.GL877881_gene6289 7.57e-144 419.0 COG1960@1|root,COG1960@2|Bacteria,2GIXS@201174|Actinobacteria,4E151@85010|Pseudonocardiales 201174|Actinobacteria I Acyl-CoA dehydrogenase, middle domain fadE26 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_10578_1 1238182.C882_0348 5.09e-81 256.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,2JREQ@204441|Rhodospirillales 204441|Rhodospirillales S Tripartite tricarboxylate transporter TctA family - - - - - - - - - - - - TctA k59_1227892_1 1535422.ND16A_0545 2.01e-17 83.6 COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria 1236|Gammaproteobacteria CP PFAM NADH Ubiquinone plastoquinone (complex I) - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M,Proton_antipo_N k59_1227892_2 595460.RRSWK_04646 1.47e-27 112.0 COG0651@1|root,COG0651@2|Bacteria,2IXRM@203682|Planctomycetes 203682|Planctomycetes CP Proton-conducting membrane transporter - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_128837_1 661478.OP10G_4020 4.84e-25 107.0 COG0285@1|root,COG0285@2|Bacteria 2|Bacteria H dihydrofolate synthase activity folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k59_858568_1 1451189.CFAL_05605 8.12e-42 156.0 COG2352@1|root,COG2352@2|Bacteria,2GKDB@201174|Actinobacteria,22K4K@1653|Corynebacteriaceae 201174|Actinobacteria H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_441621_1 378806.STAUR_0799 6.1e-14 71.2 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,42U68@68525|delta/epsilon subdivisions,2WQJS@28221|Deltaproteobacteria,2YVS8@29|Myxococcales 28221|Deltaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_1067719_1 985867.AEWF01000001_gene1767 1.02e-24 98.6 COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,2UC47@28211|Alphaproteobacteria,47FMW@766|Rickettsiales 766|Rickettsiales C Succinate dehydrogenase, cytochrome b556 subunit sdhC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_231317_1 498761.HM1_2206 1.83e-32 129.0 COG1007@1|root,COG1007@2|Bacteria,1TR55@1239|Firmicutes,25ED8@186801|Clostridia 186801|Clostridia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_231317_2 483219.LILAB_25565 3.01e-70 224.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2YYIW@29|Myxococcales 28221|Deltaproteobacteria H Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_544300_1 550540.Fbal_3739 8.99e-73 243.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_597096_1 519989.ECTPHS_02049 1.56e-27 112.0 COG3271@1|root,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,1S2EC@1236|Gammaproteobacteria,1X0UF@135613|Chromatiales 135613|Chromatiales NU Peptidase_C39 like family - - - - - - - - - - - - Peptidase_C39_2,TPR_16 k59_1119616_1 706587.Desti_3611 3.57e-91 292.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria,2MRZC@213462|Syntrophobacterales 28221|Deltaproteobacteria E TIGRFAM asparagine synthase (glutamine-hydrolyzing) - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1227926_1 882378.RBRH_00484 3.29e-19 91.7 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,1JZUU@119060|Burkholderiaceae 28216|Betaproteobacteria Q amino acid adenylation domain protein - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,Methyltransf_12,PP-binding,Thioesterase k59_1644209_1 330214.NIDE0623 1.8e-07 51.6 COG0653@1|root,COG0653@2|Bacteria,3J0E5@40117|Nitrospirae 40117|Nitrospirae U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_753610_1 1370122.JHXQ01000010_gene1455 4.19e-33 128.0 COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TU63@28211|Alphaproteobacteria,4BAN3@82115|Rhizobiaceae 28211|Alphaproteobacteria I Fatty acid hydroxylase superfamily MA20_18405 - - - - - - - - - - - FA_hydroxylase k59_962026_1 247490.KSU1_C1324 2.6e-64 223.0 COG1957@1|root,COG3055@1|root,COG3204@1|root,COG4932@1|root,COG1957@2|Bacteria,COG3055@2|Bacteria,COG3204@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - - ko:K02674,ko:K07004 - - - - ko00000,ko02035,ko02044 - - - DUF547,Laminin_G_3,Malectin k59_1438495_1 861299.J421_2534 1.73e-30 118.0 COG0287@1|root,COG1605@1|root,COG0287@2|Bacteria,COG1605@2|Bacteria,1ZT61@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Chorismate mutase type II - - 1.3.1.12,5.4.99.5 ko:K14187 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00024,M00025 R01715,R01728 RC00125,RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_2,PDH k59_1645484_1 1121943.KB899995_gene806 1.02e-11 65.5 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RMQB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tripartite tricarboxylate transporter TctA - - - - - - - - - - - - TctA k59_1645484_2 1089552.KI911559_gene3610 5.26e-27 107.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,2JRXA@204441|Rhodospirillales 204441|Rhodospirillales S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_1438498_1 1198452.Jab_1c02020 6.95e-39 141.0 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,2VINE@28216|Betaproteobacteria,4747C@75682|Oxalobacteraceae 28216|Betaproteobacteria S Cytochrome C biogenesis protein transmembrane region - - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_391259_1 1123514.KB905899_gene479 1.05e-48 160.0 COG0586@1|root,COG0586@2|Bacteria,1R5SJ@1224|Proteobacteria,1S99C@1236|Gammaproteobacteria,463J4@72273|Thiotrichales 72273|Thiotrichales S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_391259_2 631454.N177_3653 1.81e-43 147.0 COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2U9H4@28211|Alphaproteobacteria,1JP4X@119043|Rhodobiaceae 28211|Alphaproteobacteria J YjgF/chorismate_mutase-like, putative endoribonuclease - - - - - - - - - - - - YjgF_endoribonc k59_130071_1 1267535.KB906767_gene3302 2.24e-91 290.0 COG4993@1|root,COG4993@2|Bacteria,3Y6WZ@57723|Acidobacteria 57723|Acidobacteria C Pyrrolo-quinoline quinone - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_1169360_1 1239415.CM001837_gene1997 1.18e-76 246.0 COG0442@1|root,COG0442@2|Bacteria,4NEAF@976|Bacteroidetes,1HXK2@117743|Flavobacteriia,37DVE@326319|Dokdonia 976|Bacteroidetes J Prolyl-tRNA synthetase, C-terminal proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b k59_1284700_1 314230.DSM3645_28637 2.43e-78 244.0 COG1088@1|root,COG1088@2|Bacteria,2IY3D@203682|Planctomycetes 203682|Planctomycetes M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_1645491_1 522306.CAP2UW1_2868 3.24e-08 54.3 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,1KPV8@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1645491_2 105559.Nwat_2293 4.49e-29 111.0 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,1RQIE@1236|Gammaproteobacteria,1X2GE@135613|Chromatiales 135613|Chromatiales M Belongs to the skp family - - - ko:K06142 - - - - ko00000 - - - OmpH k59_814743_1 1499967.BAYZ01000105_gene3526 8.5e-54 189.0 COG0706@1|root,COG0706@2|Bacteria,2NP6C@2323|unclassified Bacteria 2|Bacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032940,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_1169363_1 1123023.JIAI01000006_gene212 5.87e-06 53.1 COG1804@1|root,COG1804@2|Bacteria,2GMW8@201174|Actinobacteria,4E85U@85010|Pseudonocardiales 201174|Actinobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_337518_1 1122164.JHWF01000017_gene566 1.15e-23 99.4 COG3931@1|root,COG3931@2|Bacteria,1QEPD@1224|Proteobacteria,1S4RU@1236|Gammaproteobacteria,1JEDT@118969|Legionellales 118969|Legionellales E N-formylglutamate amidohydrolase - - - - - - - - - - - - FGase k59_337518_2 1144275.COCOR_06534 2.04e-45 157.0 COG1796@1|root,COG1796@2|Bacteria,1QF8Z@1224|Proteobacteria,439QP@68525|delta/epsilon subdivisions,2X537@28221|Deltaproteobacteria,2Z01T@29|Myxococcales 28221|Deltaproteobacteria L Helix-hairpin-helix domain dpbF - - - - - - - - - - - HHH_5,HHH_8 k59_1438521_1 207954.MED92_17600 4.25e-105 329.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1XH9T@135619|Oceanospirillales 135619|Oceanospirillales J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_598062_1 716928.AJQT01000077_gene956 9.1e-15 73.9 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,4B8YJ@82115|Rhizobiaceae 28211|Alphaproteobacteria E threonine dehydratase - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_285229_1 2903.EOD10412 6.64e-31 127.0 2E511@1|root,2SBVM@2759|Eukaryota 2759|Eukaryota S CotH kinase protein - - - - - - - - - - - - CotH k59_442870_1 96561.Dole_0610 5.55e-21 98.2 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MJQ7@213118|Desulfobacterales 28221|Deltaproteobacteria K MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_814769_1 1238182.C882_2069 3.02e-121 364.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2JQ4Z@204441|Rhodospirillales 204441|Rhodospirillales P Belongs to the ABC transporter superfamily - - - ko:K13896 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - ABC_tran,oligo_HPY k59_912014_1 713586.KB900536_gene2798 1.69e-05 52.4 COG0515@1|root,COG1361@1|root,COG3391@1|root,COG0515@2|Bacteria,COG1361@2|Bacteria,COG3391@2|Bacteria,1RK5V@1224|Proteobacteria,1SQGH@1236|Gammaproteobacteria 1236|Gammaproteobacteria M serine threonine protein kinase - - - - - - - - - - - - - k59_498903_1 1125863.JAFN01000001_gene973 8.59e-05 52.0 COG4191@1|root,COG4191@2|Bacteria,1R5Q1@1224|Proteobacteria,42TFH@68525|delta/epsilon subdivisions,2WPEH@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase HAMP - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_337543_2 309801.trd_0972 6.26e-73 225.0 COG0094@1|root,COG0094@2|Bacteria,2G6C6@200795|Chloroflexi,27XMS@189775|Thermomicrobia 189775|Thermomicrobia J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_1325774_1 7213.XP_004532366.1 2.01e-18 83.6 COG0486@1|root,KOG1191@2759|Eukaryota,39Y5T@33154|Opisthokonta,3BNTI@33208|Metazoa 33208|Metazoa J Ferrous iron transport protein B - - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_1325774_2 566466.NOR53_841 7.31e-55 189.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1J7Q9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_442887_1 396588.Tgr7_0817 5e-119 365.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales 135613|Chromatiales O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1590425_1 1158756.AQXQ01000011_gene839 1.61e-26 110.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WXV4@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_598082_1 517418.Ctha_0472 2.24e-18 86.7 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1FEF9@1090|Chlorobi 1090|Chlorobi C electron transfer flavoprotein-ubiquinone oxidoreductase - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO k59_1492369_1 643648.Slip_0071 3.62e-62 227.0 COG0507@1|root,COG1112@1|root,COG2852@1|root,COG0507@2|Bacteria,COG1112@2|Bacteria,COG2852@2|Bacteria,1TP20@1239|Firmicutes,24BMH@186801|Clostridia,42KV6@68298|Syntrophomonadaceae 186801|Clostridia L AAA domain - - - - - - - - - - - - AAA_11,AAA_12,DUF559 k59_1381113_1 1121918.ARWE01000001_gene1766 5.74e-98 295.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,42M0U@68525|delta/epsilon subdivisions,2WJR5@28221|Deltaproteobacteria,43TXU@69541|Desulfuromonadales 28221|Deltaproteobacteria M Conserved TM helix - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - LysM,MS_channel,TM_helix k59_1169402_1 1163408.UU9_06134 3.11e-23 104.0 COG4636@1|root,COG4636@2|Bacteria,1N445@1224|Proteobacteria,1RYC9@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - - - - - - - - - - FG-GAP,VCBS k59_1492370_1 1229909.NSED_09210 4.23e-117 339.0 COG1047@1|root,arCOG00980@2157|Archaea,41T0T@651137|Thaumarchaeota 651137|Thaumarchaeota O Peptidyl-prolyl cis-trans - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - FKBP_C k59_1492370_2 436308.Nmar_1731 2.56e-28 110.0 COG0075@1|root,arCOG00082@2157|Archaea,41SZZ@651137|Thaumarchaeota 651137|Thaumarchaeota E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 k59_859619_1 1232410.KI421413_gene607 3.51e-86 260.0 COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,42PJV@68525|delta/epsilon subdivisions,2WKRG@28221|Deltaproteobacteria,43TN5@69541|Desulfuromonadales 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel k59_657731_1 1453501.JELR01000001_gene2249 1.58e-14 71.2 COG3182@1|root,COG3182@2|Bacteria,1R59B@1224|Proteobacteria,1S0MV@1236|Gammaproteobacteria,46DKY@72275|Alteromonadaceae 1236|Gammaproteobacteria S conserved secreted or membrane protein precursor - - - - - - - - - - - - PepSY_TM k59_657731_2 1280954.HPO_16655 3.55e-32 125.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TS4W@28211|Alphaproteobacteria,43Z7G@69657|Hyphomonadaceae 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_442907_1 518766.Rmar_2129 4.23e-59 199.0 COG0334@1|root,COG0334@2|Bacteria,4NEBH@976|Bacteroidetes,1FIWI@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_285260_1 1453501.JELR01000002_gene999 1.98e-42 140.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,467D0@72275|Alteromonadaceae 1236|Gammaproteobacteria K Belongs to the P(II) protein family glnK - - ko:K04751,ko:K04752 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_1169404_1 1144275.COCOR_02518 6.18e-92 284.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2WJ7W@28221|Deltaproteobacteria,2YUNU@29|Myxococcales 28221|Deltaproteobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_859624_1 572544.Ilyop_1698 2.01e-12 68.6 COG2805@1|root,COG2805@2|Bacteria,379F6@32066|Fusobacteria 32066|Fusobacteria NU COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_859624_2 519989.ECTPHS_06812 5.92e-20 88.2 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - - - - - - - - - - T2SSE k59_1444978_1 153721.MYP_732 2.18e-06 49.3 COG1143@1|root,COG1143@2|Bacteria,4NI9I@976|Bacteroidetes,47KWS@768503|Cytophagia 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_710258_1 1123253.AUBD01000005_gene282 9.24e-56 181.0 COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1X32R@135614|Xanthomonadales 135614|Xanthomonadales O Part of SUF system involved in inserting iron-sulfur clusters into proteins sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_710258_2 948106.AWZT01000053_gene1579 9.41e-14 72.4 COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2VMJ9@28216|Betaproteobacteria,1K26K@119060|Burkholderiaceae 28216|Betaproteobacteria O Uncharacterized protein family (UPF0051) sufD - - ko:K09015 - - - - ko00000 - - - UPF0051 k59_1500334_1 134676.ACPL_1124 3.42e-22 101.0 COG4972@1|root,COG4972@2|Bacteria,2IBNF@201174|Actinobacteria,4DAHI@85008|Micromonosporales 201174|Actinobacteria NU Type IV pilus assembly protein PilM; pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_1595944_1 1144932.ATTF01000025_gene1004 8.57e-54 189.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TRI9@28211|Alphaproteobacteria,4BRV4@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S MMPL family MA20_16090 - - ko:K07003 - - - - ko00000 - - - MMPL k59_760231_1 172088.AUGA01000004_gene4031 4.64e-37 135.0 COG2391@1|root,COG2391@2|Bacteria,1MZC0@1224|Proteobacteria,2U99K@28211|Alphaproteobacteria,3JYHS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S transporter component - - - ko:K07112 - - - - ko00000 - - - - k59_1331020_1 994573.T472_0215065 3.86e-65 217.0 COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,36DW7@31979|Clostridiaceae 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit atpA - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_450196_1 990285.RGCCGE502_19165 6.03e-17 83.2 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,4B7FG@82115|Rhizobiaceae 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_1075776_1 1122201.AUAZ01000007_gene3588 7.88e-192 542.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,465I5@72275|Alteromonadaceae 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iPC815.YPO4121,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658 ATP-synt_ab,ATP-synt_ab_N k59_1500348_2 1242864.D187_010064 7.61e-58 197.0 COG1651@1|root,COG1651@2|Bacteria,1RKYF@1224|Proteobacteria,42T64@68525|delta/epsilon subdivisions,2WP82@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Protein-disulfide isomerase - - - - - - - - - - - - Thioredoxin_4 k59_90949_1 1249627.D779_1887 1.92e-100 300.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1WX0N@135613|Chromatiales 135613|Chromatiales I Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_90949_2 1217718.ALOU01000007_gene1361 8e-73 224.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2VIUA@28216|Betaproteobacteria,1JZWS@119060|Burkholderiaceae 28216|Betaproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_138964_1 1056512.D515_04413 4.04e-30 122.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1XTJ2@135623|Vibrionales 135623|Vibrionales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_866503_1 1469607.KK073768_gene1963 1.68e-22 101.0 COG2199@1|root,COG2202@1|root,COG2203@1|root,COG4251@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,COG4251@2|Bacteria,1G1Z5@1117|Cyanobacteria,1HKPJ@1161|Nostocales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_3,Response_reg k59_1502109_1 525256.HMPREF0091_10717 1.35e-12 69.3 COG0159@1|root,COG0159@2|Bacteria,2GN6T@201174|Actinobacteria,4CX8N@84998|Coriobacteriia 84998|Coriobacteriia E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - - - - - - - - - - - Trp_syntA k59_1502109_2 456320.Mvol_1353 3.6e-11 70.5 COG0618@1|root,arCOG01566@2157|Archaea,2XT9H@28890|Euryarchaeota,23Q6S@183939|Methanococci 183939|Methanococci S phosphoesterase RecJ domain protein - - - - - - - - - - - - DHH,DHHA1,TrkA_N k59_138985_1 1042377.AFPJ01000023_gene661 1.37e-48 163.0 COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,1RRWP@1236|Gammaproteobacteria,465RQ@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG0811 Biopolymer transport proteins - - - - - - - - - - - - MotA_ExbB k59_1597141_1 1552758.NC00_00910 2.47e-14 68.2 COG2841@1|root,COG2841@2|Bacteria,1QB8P@1224|Proteobacteria,1T6SZ@1236|Gammaproteobacteria,1X83B@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF465) uptF - - - - - - - - - - - DUF465 k59_1332180_1 404589.Anae109_3458 9.92e-68 221.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,42NMY@68525|delta/epsilon subdivisions,2WJ8S@28221|Deltaproteobacteria,2YU74@29|Myxococcales 28221|Deltaproteobacteria M Mur ligase family, catalytic domain mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1175920_2 998088.B565_3719 5.5e-65 201.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1Y3ZD@135624|Aeromonadales 135624|Aeromonadales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_1332182_1 1121035.AUCH01000008_gene982 1.5e-66 220.0 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,2VHR0@28216|Betaproteobacteria,2KUNT@206389|Rhodocyclales 206389|Rhodocyclales T Domain of unknown function (DUF3391) - - - - - - - - - - - - DUF3391,HD_5 k59_1332182_2 1380367.JIBC01000007_gene875 7.15e-36 131.0 299ER@1|root,2ZWHI@2|Bacteria,1RAA3@1224|Proteobacteria,2U904@28211|Alphaproteobacteria,3ZZFW@60136|Sulfitobacter 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1537485_1 1125863.JAFN01000001_gene2795 1.29e-16 79.7 COG0723@1|root,COG0723@2|Bacteria,1NINP@1224|Proteobacteria,42VKD@68525|delta/epsilon subdivisions,2WRHY@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Rieske 2Fe-2S domain pcmE - 1.10.9.1 ko:K02636,ko:K03886 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00151,M00162 R03817,R08409 RC01002 ko00000,ko00001,ko00002,ko00194,ko01000 - - - Rieske k59_452060_1 1479237.JMLY01000001_gene1338 3.58e-30 113.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,465S7@72275|Alteromonadaceae 1236|Gammaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_452060_2 1163617.SCD_n02244 1.17e-19 87.0 COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2VKXA@28216|Betaproteobacteria 28216|Betaproteobacteria J 40-residue YVTN family beta-propeller repeat protein - - - - - - - - - - - - Cytochrom_D1,Lactonase k59_239543_1 330214.NIDE3974 2.98e-91 280.0 COG1012@1|root,COG1012@2|Bacteria,3J0YN@40117|Nitrospirae 40117|Nitrospirae C Aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_1294658_1 1188256.BASI01000002_gene2971 5.89e-15 80.5 COG0243@1|root,COG0243@2|Bacteria,1NSXR@1224|Proteobacteria,2TYAZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Molydopterin dinucleotide binding domain - GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.8.2.4 ko:K16964 ko00920,map00920 - R09500 RC02555 ko00000,ko00001,ko01000 - - - Molybdopterin,Molydop_binding k59_508869_2 261292.Nit79A3_2374 2.05e-23 99.4 COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2WAY9@28216|Betaproteobacteria,371NX@32003|Nitrosomonadales 28216|Betaproteobacteria O Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_1655524_1 1499967.BAYZ01000105_gene3533 4.56e-63 207.0 COG0303@1|root,COG0303@2|Bacteria,2NP4N@2323|unclassified Bacteria 2|Bacteria H MoeA N-terminal region (domain I and II) moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1175939_1 316055.RPE_2524 1.93e-07 56.6 COG4122@1|root,COG4122@2|Bacteria,1QYVJ@1224|Proteobacteria,2TXZU@28211|Alphaproteobacteria,3K6UZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21 k59_552556_1 414684.RC1_1632 6.6e-46 166.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,2JPIV@204441|Rhodospirillales 204441|Rhodospirillales I COG1960 Acyl-CoA dehydrogenases - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_1502203_1 269799.Gmet_3364 2.15e-41 155.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU Type II and III secretion system protein gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_1077444_1 450851.PHZ_c2522 2.34e-05 49.7 29XGN@1|root,30J76@2|Bacteria,1PWIS@1224|Proteobacteria,2V6SY@28211|Alphaproteobacteria,2KJF4@204458|Caulobacterales 204458|Caulobacterales S Methylmuconolactone methyl-isomerase - - - - - - - - - - - - EthD k59_1175948_1 1144275.COCOR_07804 1.81e-39 144.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,42NQW@68525|delta/epsilon subdivisions,2WJZM@28221|Deltaproteobacteria,2YUS5@29|Myxococcales 28221|Deltaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_711614_1 771875.Ferpe_0884 6.57e-07 56.2 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GC00@200918|Thermotogae 200918|Thermotogae G Belongs to the PEP-utilizing enzyme family - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_970215_1 1283300.ATXB01000001_gene493 2.11e-82 264.0 COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,1RR35@1236|Gammaproteobacteria 1236|Gammaproteobacteria P TrkA-N domain - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_N k59_1597190_1 1209072.ALBT01000064_gene1161 3.64e-06 50.4 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,1FGTR@10|Cellvibrio 1236|Gammaproteobacteria D Reduces the stability of FtsZ polymers in the presence of ATP zapE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032153,GO:0044424,GO:0044464,GO:0051301 - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_1597190_2 551789.ATVJ01000001_gene2353 8.17e-16 76.6 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,43X9R@69657|Hyphomonadaceae 28211|Alphaproteobacteria C Electron transfer flavoprotein-ubiquinone oxidoreductase etf - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_866570_1 1173026.Glo7428_2690 1.81e-52 175.0 COG1028@1|root,COG1028@2|Bacteria,1G67A@1117|Cyanobacteria 1117|Cyanobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_866570_2 330214.NIDE2415 9.28e-11 61.2 COG0248@1|root,COG2206@1|root,COG0248@2|Bacteria,COG2206@2|Bacteria,3J0K5@40117|Nitrospirae 2|Bacteria FP Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology ppx - 3.6.1.11,3.6.1.40 ko:K01524,ko:K07012 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000,ko02048 - - - HD,Helicase_C,Ppx-GppA,Response_reg k59_920963_1 383372.Rcas_0816 1.01e-36 126.0 COG1917@1|root,COG1917@2|Bacteria,2G7C7@200795|Chloroflexi,377HW@32061|Chloroflexia 32061|Chloroflexia S PFAM Cupin 2 conserved barrel domain protein - - - - - - - - - - - - - k59_92540_1 411464.DESPIG_01959 4.9e-39 141.0 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,42P58@68525|delta/epsilon subdivisions,2WKYK@28221|Deltaproteobacteria,2M9J5@213115|Desulfovibrionales 28221|Deltaproteobacteria M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_0547 Asp_Glu_race k59_920964_1 395494.Galf_0710 6.33e-19 81.6 2DY16@1|root,347JT@2|Bacteria,1P2MN@1224|Proteobacteria,2W4PM@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_920964_2 592015.HMPREF1705_01186 0.000465 44.7 COG1030@1|root,COG1030@2|Bacteria 2|Bacteria - - - - - ko:K07403 - - - - ko00000 - - - CLP_protease,NfeD k59_920964_3 314231.FP2506_04316 5.41e-32 117.0 COG2010@1|root,COG2010@2|Bacteria,1MZSK@1224|Proteobacteria,2UC5Q@28211|Alphaproteobacteria,2PM9R@255475|Aurantimonadaceae 28211|Alphaproteobacteria C COG2010 Cytochrome c, mono- and diheme variants - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_1332220_1 349106.PsycPRwf_0193 5.97e-71 228.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,3NK1R@468|Moraxellaceae 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iPC815.YPO4121,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658 ATP-synt_ab,ATP-synt_ab_N k59_1294714_1 391626.OAN307_c08620 8.34e-56 193.0 COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,2VFZH@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the synthesis of activated sulfate cysC - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,ATP-sulfurylase,HTH_24,PUA_2 k59_1077465_1 379731.PST_2685 7.2e-16 75.5 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1RP9U@1236|Gammaproteobacteria,1Z1TZ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiA GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K01802,ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_92548_1 373994.Riv7116_0342 5.63e-80 253.0 COG4313@1|root,COG4313@2|Bacteria,1G150@1117|Cyanobacteria 1117|Cyanobacteria C Protein involved in meta-pathway of phenol degradation - - - - - - - - - - - - Phenol_MetA_deg k59_1129584_1 330214.NIDE0901 8.52e-91 283.0 COG1271@1|root,COG1271@2|Bacteria 2|Bacteria C aerobic electron transport chain - - 1.10.3.14 ko:K00425,ko:K08738 ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00153,M00595 R10151,R11325 RC00061,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.3,3.D.4.6 - - Cyt_bd_oxida_I,Cytochrome_CBB3 k59_1387648_1 1231336.L248_0972 3.59e-27 108.0 COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4HA74@91061|Bacilli,3F3N2@33958|Lactobacillaceae 91061|Bacilli L hydrolase, TatD family tatD GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_824874_1 1049564.TevJSym_at00390 1.08e-112 341.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1J4IR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 - ko:K03688 - - - - ko00000 - - iYL1228.KPN_04331 ABC1 k59_1294722_1 1458275.AZ34_06705 2.32e-18 82.0 COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,2VQUQ@28216|Betaproteobacteria,4ABNK@80864|Comamonadaceae 28216|Betaproteobacteria D Maf-like protein yceF - - ko:K06287 - - - - ko00000 - - - Maf k59_1294722_2 396588.Tgr7_1916 6.74e-54 186.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1WW0Z@135613|Chromatiales 135613|Chromatiales CI TIGRFAM Oxaloacetate decarboxylase, alpha subunit - - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_866590_1 765912.Thimo_1302 1.54e-42 150.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1WWFA@135613|Chromatiales 135613|Chromatiales E PFAM Prephenate dehydratase - - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_866590_2 472759.Nhal_2632 1.76e-29 114.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1WXIX@135613|Chromatiales 135613|Chromatiales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1446254_1 1238190.AMQY01000010_gene2398 2.78e-82 264.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1XH4H@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_761485_1 1415778.JQMM01000001_gene902 5.84e-74 236.0 COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,1T1NH@1236|Gammaproteobacteria,1J5ZF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EGP Acetyl-coenzyme A transporter 1 ampG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015835,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1901264,GO:1902600 - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_1022776_1 439235.Dalk_2437 4.82e-69 218.0 COG2126@1|root,COG2126@2|Bacteria,1MXCS@1224|Proteobacteria,42NVQ@68525|delta/epsilon subdivisions,2WJFT@28221|Deltaproteobacteria,2MHX5@213118|Desulfobacterales 28221|Deltaproteobacteria J Ion transport protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans k59_452132_1 377629.TERTU_3170 5.86e-06 47.0 COG4968@1|root,COG4968@2|Bacteria,1PSJJ@1224|Proteobacteria,1RVXN@1236|Gammaproteobacteria,2PNZT@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria NU Type IV minor pilin ComP, DNA uptake sequence receptor - - - ko:K02655 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - ComP_DUS,N_methyl k59_552610_1 95619.PM1_0226320 5.23e-69 224.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Membrane-bound serine protease (ClpP class) nfeD - - ko:K07403 - - - - ko00000 - - - NfeD k59_1597225_1 314285.KT71_05230 8.34e-27 111.0 COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1SN4C@1236|Gammaproteobacteria,1J9KW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit - - - - - - - - - - - - Methyltrans_RNA k59_508960_1 1493511.A0A0E3FQZ7_9CAUD 1.88e-50 181.0 4QBUC@10239|Viruses,4QQGQ@28883|Caudovirales,4QHY3@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_508960_2 1493511.A0A0E3FQN7_9CAUD 4.41e-07 50.4 4QF7I@10239|Viruses,4QT9A@28883|Caudovirales,4QKJH@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1446271_2 483219.LILAB_03300 9.44e-49 160.0 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,42SD2@68525|delta/epsilon subdivisions,2WP7H@28221|Deltaproteobacteria,2YVHR@29|Myxococcales 28221|Deltaproteobacteria G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 ptsN - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_345976_1 477974.Daud_0226 7.77e-12 66.2 COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,248SY@186801|Clostridia,26186@186807|Peptococcaceae 186801|Clostridia J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_345976_2 665942.HMPREF1022_00792 4.25e-12 63.2 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,42V3Y@68525|delta/epsilon subdivisions,2WRMX@28221|Deltaproteobacteria,2MCHF@213115|Desulfovibrionales 28221|Deltaproteobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_1183327_2 1052684.PPM_2854 1.35e-17 79.0 COG0386@1|root,COG0386@2|Bacteria,1V3M3@1239|Firmicutes,4HH5Q@91061|Bacilli,26V56@186822|Paenibacillaceae 91061|Bacilli O Belongs to the glutathione peroxidase family bsaA - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_930180_1 1380391.JIAS01000014_gene2059 4.92e-105 312.0 COG1250@1|root,COG1250@2|Bacteria,1MV8M@1224|Proteobacteria,2TRAW@28211|Alphaproteobacteria,2JQXY@204441|Rhodospirillales 204441|Rhodospirillales I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - 3HCDH,3HCDH_N k59_18614_1 247490.KSU1_B0323 8.39e-251 707.0 COG1523@1|root,COG1523@2|Bacteria,2IX65@203682|Planctomycetes 203682|Planctomycetes G Carbohydrate-binding module 48 (Isoamylase N-terminal domain) - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_1603814_1 330214.NIDE1106 2.67e-65 209.0 COG0126@1|root,COG0126@2|Bacteria,3J0DE@40117|Nitrospirae 40117|Nitrospirae G Phosphoglycerate kinase pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_1603814_2 330214.NIDE1107 2.59e-33 123.0 COG0057@1|root,COG0057@2|Bacteria,3J0D8@40117|Nitrospirae 40117|Nitrospirae C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family - - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_147190_2 756067.MicvaDRAFT_2432 8.81e-46 168.0 COG0438@1|root,COG0463@1|root,COG1215@1|root,COG1216@1|root,COG5185@1|root,COG0438@2|Bacteria,COG0463@2|Bacteria,COG1215@2|Bacteria,COG1216@2|Bacteria,COG5185@2|Bacteria,1G3E3@1117|Cyanobacteria,1HH4F@1150|Oscillatoriales 1117|Cyanobacteria DM PFAM Glycosyl transferase family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2 k59_460477_1 314254.OA2633_01751 1.43e-83 266.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,43WM2@69657|Hyphomonadaceae 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.44,6.2.1.48 ko:K00666,ko:K02182,ko:K20034 ko00920,map00920 - R10820 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_405702_1 1191523.MROS_0605 3.17e-24 103.0 COG1232@1|root,COG1232@2|Bacteria 2|Bacteria H protoporphyrinogen oxidase activity hemG - 1.14.19.9,1.3.3.15,1.3.3.4 ko:K00231,ko:K14266 ko00404,ko00860,ko01100,ko01110,ko01130,map00404,map00860,map01100,map01110,map01130 M00121,M00789,M00790 R03222,R04178,R09570 RC00885,RC00949 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS09325 Amino_oxidase k59_405702_2 1288494.EBAPG3_2300 5.92e-74 233.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,2VH3K@28216|Betaproteobacteria,3733V@32003|Nitrosomonadales 28216|Betaproteobacteria O AIR synthase related protein, N-terminal domain - - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_520693_1 1396141.BATP01000044_gene1492 2.09e-27 114.0 COG0644@1|root,COG0644@2|Bacteria,46TIC@74201|Verrucomicrobia 74201|Verrucomicrobia C Tryptophan halogenase - - - - - - - - - - - - Trp_halogenase k59_1514045_2 314345.SPV1_06634 7.51e-75 231.0 28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF4126) - - - - - - - - - - - - DUF4126 k59_248072_1 485913.Krac_8961 2.28e-49 172.0 COG0114@1|root,COG0114@2|Bacteria,2GBNI@200795|Chloroflexi 200795|Chloroflexi C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_1453551_1 395493.BegalDRAFT_2461 5.35e-192 551.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,4623I@72273|Thiotrichales 72273|Thiotrichales O Cytochrome c-type biogenesis protein CcmF C-terminal - - - - - - - - - - - - CcmF_C,Cytochrom_C_asm k59_1453551_2 95619.PM1_0209360 1.12e-29 123.0 COG2199@1|root,COG3706@2|Bacteria,1RDI8@1224|Proteobacteria,1S436@1236|Gammaproteobacteria 1236|Gammaproteobacteria T (GGDEF) domain - - - - - - - - - - - - GGDEF k59_1667494_1 582515.KR51_00005380 9.42e-20 94.0 COG0530@1|root,COG0530@2|Bacteria,1G1Y9@1117|Cyanobacteria 1117|Cyanobacteria P Sodium calcium exchanger ecm27 - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_1603827_1 861299.J421_2423 7.87e-108 336.0 COG0495@1|root,COG0495@2|Bacteria,1ZSXC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Leucyl-tRNA synthetase, Domain 2 leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_520716_1 1121930.AQXG01000032_gene948 1.17e-95 307.0 COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,1IR8E@117747|Sphingobacteriia 976|Bacteroidetes P AcrB/AcrD/AcrF family - - - ko:K07787,ko:K15726 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 - - ACR_tran k59_1086639_1 926566.Terro_0573 2.09e-49 166.0 COG1721@1|root,COG1721@2|Bacteria,3Y5XW@57723|Acidobacteria,2JMDZ@204432|Acidobacteriia 204432|Acidobacteriia S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_1086639_2 379066.GAU_3101 1.5e-09 58.5 COG0714@1|root,COG0714@2|Bacteria,1ZUSV@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_190567_1 1247649.D560_0857 6.83e-07 56.6 COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,2VH7E@28216|Betaproteobacteria,3T685@506|Alcaligenaceae 28216|Betaproteobacteria S Calcineurin-like phosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos k59_303157_1 1440774.Y900_025785 2.29e-37 136.0 COG4221@1|root,COG4221@2|Bacteria,2I3PD@201174|Actinobacteria,235SV@1762|Mycobacteriaceae 201174|Actinobacteria S Dehydrogenase fabG3 - 1.1.1.53 ko:K00038 ko00140,ko01100,map00140,map01100 - R04831,R04834,R04844,R04847 RC00139,RC01219,RC01220 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_1514077_1 1121904.ARBP01000003_gene6372 7.05e-90 279.0 COG2382@1|root,COG2382@2|Bacteria,4NGBK@976|Bacteroidetes,47K7D@768503|Cytophagia 976|Bacteroidetes P esterase - - - - - - - - - - - - Esterase k59_561037_1 1297581.H919_04939 1.54e-25 109.0 COG0840@1|root,COG0840@2|Bacteria,1TRTV@1239|Firmicutes,4H9M1@91061|Bacilli 91061|Bacilli NT chemotaxis protein hemAT - - ko:K06595 - - - - ko00000,ko02035 - - - MCPsignal,Protoglobin k59_1514083_1 999419.HMPREF1077_00429 5.53e-20 90.5 COG1752@1|root,COG1752@2|Bacteria,4NERH@976|Bacteroidetes,2FNX7@200643|Bacteroidia,22XKQ@171551|Porphyromonadaceae 976|Bacteroidetes S Phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_874681_1 1303518.CCALI_01155 3.33e-102 305.0 COG1064@1|root,COG1064@2|Bacteria 2|Bacteria P alcohol dehydrogenase adhA - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1667522_1 323848.Nmul_A1417 8.39e-70 231.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,372ME@32003|Nitrosomonadales 28216|Betaproteobacteria I AMP-dependent synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_101819_1 631454.N177_0614 6.97e-133 389.0 COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria 28211|Alphaproteobacteria G glucose sorbosone - - - - - - - - - - - - GSDH k59_612690_1 1205910.B005_5575 7.7e-73 229.0 COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,4EFSC@85012|Streptosporangiales 201174|Actinobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_1138634_1 309803.CTN_0733 8.12e-05 44.3 COG5002@1|root,COG5002@2|Bacteria,2GC3R@200918|Thermotogae 200918|Thermotogae T Histidine kinase - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9 k59_1138634_2 234267.Acid_4208 1.15e-27 107.0 COG1913@1|root,COG1913@2|Bacteria,3Y880@57723|Acidobacteria 57723|Acidobacteria S Peptidase family M54 - - - ko:K06974 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M54 k59_147229_1 667014.Thein_0356 1.12e-39 147.0 2DK8S@1|root,308W6@2|Bacteria 2|Bacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_1394957_1 1094715.CM001373_gene2501 8.65e-70 215.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1JDWB@118969|Legionellales 118969|Legionellales O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_1514120_1 472759.Nhal_0349 4.31e-94 288.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_1394959_1 330214.NIDE2410 3.67e-81 266.0 COG0673@1|root,COG1063@1|root,COG0673@2|Bacteria,COG1063@2|Bacteria,3J0WC@40117|Nitrospirae 40117|Nitrospirae C Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - ADH_zinc_N,GFO_IDH_MocA k59_1545548_1 1346.DQ08_06480 2.33e-05 50.4 COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,4H9KP@91061|Bacilli 91061|Bacilli KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1138667_1 105559.Nwat_0227 1.6e-62 204.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1WWB9@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_248137_1 448385.sce5197 5.35e-46 165.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2WJSW@28221|Deltaproteobacteria,2YUEU@29|Myxococcales 28221|Deltaproteobacteria G Belongs to the pyruvate kinase family - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK k59_1453601_1 472759.Nhal_0455 9.36e-129 386.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1WW1J@135613|Chromatiales 135613|Chromatiales E PFAM peptidase M3A and M3B, thimet oligopeptidase F - - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_1453601_2 177437.HRM2_13640 2.17e-08 61.2 COG3103@1|root,COG4991@2|Bacteria,1QWMT@1224|Proteobacteria,42VQW@68525|delta/epsilon subdivisions,2WR75@28221|Deltaproteobacteria,2MKB9@213118|Desulfobacterales 28221|Deltaproteobacteria T Bacterial SH3 domain homologues - - - ko:K07184 - - - - ko00000 - - - SH3_3 k59_1453601_3 472759.Nhal_0456 1.9e-67 213.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1WWV1@135613|Chromatiales 135613|Chromatiales L PFAM Endonuclease Exonuclease phosphatase - - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_248151_1 426117.M446_1580 3.53e-63 210.0 COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,2TYKE@28211|Alphaproteobacteria,1JZI1@119045|Methylobacteriaceae 28211|Alphaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_303229_1 748727.CLJU_c05430 4.7e-06 54.7 COG0438@1|root,COG0438@2|Bacteria,1UASH@1239|Firmicutes,248VW@186801|Clostridia,36E4C@31979|Clostridiaceae 186801|Clostridia M glycosyl transferase - - 2.4.1.349 ko:K12994 - - - - ko00000,ko01000,ko01003,ko01005 - GT4 - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_1545570_1 330214.NIDE0225 7.32e-149 433.0 COG1007@1|root,COG1007@2|Bacteria,3J0FN@40117|Nitrospirae 40117|Nitrospirae C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1138687_1 1117647.M5M_16055 1.82e-80 248.0 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria,1J6XD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Outer membrane lipoprotein-sorting protein VPA0557 - - - - - - - - - - - LolA_like k59_612752_1 1051985.l11_04990 1.47e-12 72.4 COG3464@1|root,COG3464@2|Bacteria,1N2KA@1224|Proteobacteria,2VKCW@28216|Betaproteobacteria,2KSQ2@206351|Neisseriales 206351|Neisseriales L Helix-turn-helix domain of transposase family ISL3 - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3 k59_1667614_1 697282.Mettu_0758 6.62e-86 285.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1XEDS@135618|Methylococcales 135618|Methylococcales E Glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_460582_2 330214.NIDE3612 3.76e-32 122.0 2C8FN@1|root,2ZBER@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1603885_1 1458427.BAWN01000012_gene705 2.87e-79 256.0 COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria,2WE9S@28216|Betaproteobacteria 28216|Betaproteobacteria I BadF/BadG/BcrA/BcrD ATPase family - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_405817_2 1121930.AQXG01000001_gene1410 1.43e-14 73.2 COG0781@1|root,COG0781@2|Bacteria,4NDVR@976|Bacteroidetes 976|Bacteroidetes K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_720236_1 1337093.MBE-LCI_0911 3.83e-127 372.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2TRPR@28211|Alphaproteobacteria,2P8Q4@245186|Loktanella 28211|Alphaproteobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_720236_2 1242864.D187_003396 6.63e-137 404.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ28@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU PFAM Type II secretion system protein E pilT-1 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1603891_1 1047013.AQSP01000144_gene902 6.42e-81 251.0 COG0399@1|root,COG0399@2|Bacteria,2NQIB@2323|unclassified Bacteria 2|Bacteria E DegT/DnrJ/EryC1/StrS aminotransferase family - - 2.6.1.102 ko:K13010 ko00520,map00520 - R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k59_520841_1 1244869.H261_16952 3.97e-18 86.7 COG2172@1|root,COG2203@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,1PFBR@1224|Proteobacteria,2U1RE@28211|Alphaproteobacteria,2JZB7@204441|Rhodospirillales 204441|Rhodospirillales T Sigma factor PP2C-like phosphatases - - - - - - - - - - - - GAF_2,HATPase_c_2,SpoIIE k59_520841_2 391735.Veis_4267 5.19e-47 164.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2VQCB@28216|Betaproteobacteria,4AG75@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - - ko:K07546 ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220 M00418 R05599 RC01435 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1395000_2 323261.Noc_1891 1.7e-75 238.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1WW4A@135613|Chromatiales 135613|Chromatiales I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_561122_1 323261.Noc_0510 9.37e-65 211.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1WX0A@135613|Chromatiales 135613|Chromatiales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_190678_1 330214.NIDE3909 5.82e-93 282.0 COG0767@1|root,COG0767@2|Bacteria 2|Bacteria Q ABC-type transport system involved in resistance to organic solvents, permease component iamB - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE,STAS,STAS_2 k59_931345_2 1120973.AQXL01000132_gene2202 2.6e-59 196.0 COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,4HA5K@91061|Bacilli,2785X@186823|Alicyclobacillaceae 91061|Bacilli E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_1604563_2 614083.AWQR01000022_gene106 5.03e-23 100.0 COG2159@1|root,COG2159@2|Bacteria,1MXI7@1224|Proteobacteria,2VP80@28216|Betaproteobacteria,4ADEX@80864|Comamonadaceae 28216|Betaproteobacteria S Amidohydrolase - - 4.1.1.103,4.1.1.46 ko:K07045,ko:K14333,ko:K20941 ko00362,ko00627,ko01120,map00362,map00627,map01120 - R00821,R11353 RC00390,RC00569 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_931348_1 113395.AXAI01000018_gene4862 7.79e-65 206.0 COG1024@1|root,COG1024@2|Bacteria,1MVPQ@1224|Proteobacteria,2TTJ4@28211|Alphaproteobacteria,3JSCJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 k59_1546662_2 518766.Rmar_0096 4.61e-10 58.5 COG2128@1|root,COG2128@2|Bacteria,4NI74@976|Bacteroidetes,1FJDM@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_1032214_1 857087.Metme_1220 2.31e-21 94.4 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1032214_2 1288494.EBAPG3_8610 1.63e-19 87.8 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VK3J@28216|Betaproteobacteria,3725A@32003|Nitrosomonadales 28216|Betaproteobacteria E PFAM Orn DAP Arg decarboxylase 2 - - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_102902_1 653045.Strvi_5955 1.55e-08 60.8 COG1846@1|root,COG1940@1|root,COG3415@1|root,COG1846@2|Bacteria,COG1940@2|Bacteria,COG3415@2|Bacteria,2GIU4@201174|Actinobacteria 201174|Actinobacteria GK ROK family - - - - - - - - - - - - HTH_23,HTH_29,MarR_2,ROK k59_102902_2 880071.Fleli_2325 8.17e-11 66.6 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,4NKPG@976|Bacteroidetes,47TCB@768503|Cytophagia 976|Bacteroidetes L Winged helix-turn helix - - - - - - - - - - - - DDE_3,HTH_29,HTH_33 k59_1139781_1 330214.NIDE4329 7.42e-66 217.0 COG0728@1|root,COG0728@2|Bacteria,3J0CQ@40117|Nitrospirae 40117|Nitrospirae S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_1087759_1 1123393.KB891328_gene590 1.02e-35 138.0 COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,2VMT1@28216|Betaproteobacteria,1KSY9@119069|Hydrogenophilales 119069|Hydrogenophilales NU Secretin and TonB N terminus short domain - - - - - - - - - - - - Secretin k59_191764_1 589924.Ferp_1907 2.3e-19 86.7 COG1024@1|root,arCOG00239@2157|Archaea,2Y2NP@28890|Euryarchaeota,246M0@183980|Archaeoglobi 183980|Archaeoglobi I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_613860_1 1122138.AQUZ01000001_gene1820 7.91e-83 279.0 COG3696@1|root,COG3696@2|Bacteria,2H303@201174|Actinobacteria,4DWUS@85009|Propionibacteriales 201174|Actinobacteria P AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_1184255_1 1232410.KI421421_gene3631 2.31e-72 231.0 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,42MNS@68525|delta/epsilon subdivisions,2WSQX@28221|Deltaproteobacteria 28221|Deltaproteobacteria C ATP ADP translocase - - - ko:K03301 - - - - ko00000 2.A.12 - - MFS_1,TLC k59_1184255_2 1397527.Q670_13150 5.39e-11 62.8 COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,1S40A@1236|Gammaproteobacteria,1XJVW@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - - - - - - - - - - DUF924 k59_1604588_1 1219031.BBJR01000038_gene3030 1.96e-54 185.0 COG1171@1|root,COG1171@2|Bacteria,1QTY3@1224|Proteobacteria,2WGHB@28216|Betaproteobacteria,4ACE7@80864|Comamonadaceae 28216|Betaproteobacteria E Pyridoxal-phosphate dependent enzyme dpaL - 4.3.1.15 ko:K01751 - - - - ko00000,ko01000 - - - PALP k59_1184257_2 28072.Nos7524_0716 7.44e-09 60.5 COG3751@1|root,COG3751@2|Bacteria,1GHDG@1117|Cyanobacteria,1HQY6@1161|Nostocales 1117|Cyanobacteria O Putative 2OG-Fe(II) oxygenase - - - - - - - - - - - - 2OG-FeII_Oxy_5 k59_191778_1 1110502.TMO_0720 4.78e-73 224.0 COG3415@1|root,COG3415@2|Bacteria,1RDMQ@1224|Proteobacteria,2U7PU@28211|Alphaproteobacteria,2JZ7V@204441|Rhodospirillales 204441|Rhodospirillales L Winged helix-turn helix - - - - - - - - - - - - HTH_32,HTH_33 k59_197465_1 1131266.ARWQ01000001_gene1319 7.67e-10 59.3 COG0175@1|root,arCOG00124@2157|Archaea,41S9Q@651137|Thaumarchaeota 651137|Thaumarchaeota E Phosphoadenosine phosphosulfate reductase family - - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_197465_2 1382306.JNIM01000001_gene2598 1.08e-43 153.0 COG2046@1|root,COG2046@2|Bacteria,2G7JD@200795|Chloroflexi 200795|Chloroflexi H Catalyzes the synthesis of activated sulfate sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_1459583_2 4577.GRMZM2G044337_P01 3.88e-09 60.1 COG0076@1|root,KOG1383@2759|Eukaryota,37IN2@33090|Viridiplantae,3G8PT@35493|Streptophyta,3KWQI@4447|Liliopsida,3I8C6@38820|Poales 35493|Streptophyta E Aminotransferase class-V - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0006629,GO:0006643,GO:0006665,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0012505,GO:0016020,GO:0016042,GO:0030149,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046466,GO:0071704,GO:1901564,GO:1901565,GO:1901575 4.1.2.27 ko:K01634 ko00600,ko01100,ko04071,map00600,map01100,map04071 M00100 R02464,R06516 RC00264,RC00721,RC01266 ko00000,ko00001,ko00002,ko01000 - - - Pyridoxal_deC k59_1608243_1 1232437.KL661978_gene3782 2.6e-10 61.2 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MJZH@213118|Desulfobacterales 28221|Deltaproteobacteria T CHASE2 - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_880212_1 1333523.L593_04315 2.58e-17 87.0 COG0737@1|root,arCOG02832@2157|Archaea,2XW96@28890|Euryarchaeota,23UQM@183963|Halobacteria 183963|Halobacteria F 5'-nucleotidase - - - - - - - - - - - - 5_nucleotid_C,Metallophos k59_1459601_1 667014.Thein_0868 2.93e-17 82.4 COG1899@1|root,COG1899@2|Bacteria,2GIEP@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria O peptidyl-lysine modification to peptidyl-hypusine - - - - - - - - - - - - - k59_1459601_2 272631.ML2703 4.98e-09 56.6 COG0492@1|root,COG3118@1|root,COG0492@2|Bacteria,COG3118@2|Bacteria,2GKD2@201174|Actinobacteria,234E1@1762|Mycobacteriaceae 201174|Actinobacteria C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 ko:K00384,ko:K03671 ko00450,ko04621,ko05418,map00450,map04621,map05418 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000,ko03110 - - iNJ661.Rv3913 Pyr_redox_2 k59_1146127_1 1304888.ATWF01000001_gene704 1.7e-73 238.0 COG2804@1|root,COG2804@2|Bacteria,2GEP7@200930|Deferribacteres 200930|Deferribacteres NU General secretory system II protein E domain protein - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_1551983_1 290400.Jann_2488 1.92e-76 251.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the GcvT family dmgdh3 - 1.5.8.4 ko:K00315 ko00260,ko01100,map00260,map01100 - R01565 RC00181 ko00000,ko00001,ko01000 - - - DAO,FAO_M,GCV_T,GCV_T_C k59_1146129_1 445972.ANACOL_02528 1.39e-77 244.0 COG2513@1|root,COG2513@2|Bacteria,1TQVY@1239|Firmicutes,24AC5@186801|Clostridia,3WPYR@541000|Ruminococcaceae 186801|Clostridia GM Phosphoenolpyruvate phosphomutase prpB - 4.1.3.30,4.1.3.32 ko:K03417,ko:K20454 ko00640,ko00760,ko01120,map00640,map00760,map01120 - R00409,R01355 RC00286,RC00287,RC01810 ko00000,ko00001,ko01000 - - - PEP_mutase k59_566603_1 1469245.JFBG01000023_gene1270 4.57e-157 463.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1X2Q6@135613|Chromatiales 135613|Chromatiales C SNARE associated Golgi protein - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_725723_1 631362.Thi970DRAFT_01461 0.000279 44.7 COG0457@1|root,COG0457@2|Bacteria,1R50I@1224|Proteobacteria,1RSP6@1236|Gammaproteobacteria,1WY6N@135613|Chromatiales 135613|Chromatiales S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1146135_1 1041522.MCOL_V200385 5.5e-07 56.6 COG0243@1|root,COG0243@2|Bacteria,2I8HX@201174|Actinobacteria,232RY@1762|Mycobacteriaceae 201174|Actinobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1252609_1 671143.DAMO_0003 3.92e-49 166.0 COG0785@1|root,COG0785@2|Bacteria,2NPE4@2323|unclassified Bacteria 2|Bacteria O Cytochrome C biogenesis protein transmembrane region ccdA - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD k59_1459622_1 1509405.GV67_03880 1.02e-10 62.8 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2TUMJ@28211|Alphaproteobacteria,4BDSM@82115|Rhizobiaceae 28211|Alphaproteobacteria E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 k59_1459622_2 1207063.P24_05464 1.14e-33 122.0 COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,2U84Q@28211|Alphaproteobacteria,2JZR9@204441|Rhodospirillales 204441|Rhodospirillales P Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides - - - ko:K07232 - - - - ko00000 - - - ChaC k59_197519_1 225937.HP15_2344 3.04e-49 170.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,4653T@72275|Alteromonadaceae 1236|Gammaproteobacteria I Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed fadI - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1036645_1 1304885.AUEY01000013_gene3080 1.92e-13 72.4 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria,2MIAI@213118|Desulfobacterales 28221|Deltaproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_880246_1 436308.Nmar_1224 2.77e-24 93.2 arCOG07192@1|root,arCOG07192@2157|Archaea,41SVA@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_880246_2 436308.Nmar_1225 1.54e-62 199.0 COG0109@1|root,arCOG00479@2157|Archaea,41SDQ@651137|Thaumarchaeota 651137|Thaumarchaeota H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group - - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_1189449_1 1254432.SCE1572_32710 2.27e-23 107.0 COG0683@1|root,COG2010@1|root,COG0683@2|Bacteria,COG2010@2|Bacteria,1R4K1@1224|Proteobacteria,42Z9W@68525|delta/epsilon subdivisions,2WUMZ@28221|Deltaproteobacteria,2YTTR@29|Myxococcales 28221|Deltaproteobacteria C Periplasmic binding protein - - - - - - - - - - - - Cytochrom_C,Peripla_BP_6 k59_153440_1 929713.NIASO_16905 1.83e-35 132.0 COG0304@1|root,COG0304@2|Bacteria,4NEKC@976|Bacteroidetes,1IPBP@117747|Sphingobacteriia 976|Bacteroidetes I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_153440_2 861299.J421_3269 2e-27 101.0 COG0236@1|root,COG0236@2|Bacteria,1ZU0X@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_619586_1 1123354.AUDR01000014_gene1073 4.27e-25 102.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2VHK3@28216|Betaproteobacteria,1KRYI@119069|Hydrogenophilales 119069|Hydrogenophilales I GHMP kinases N terminal domain - - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_197554_1 1235799.C818_02571 5.94e-31 119.0 COG1357@1|root,COG1357@2|Bacteria,1VK1Z@1239|Firmicutes,25C0B@186801|Clostridia,27KSX@186928|unclassified Lachnospiraceae 2|Bacteria S Pentapeptide repeats (9 copies) - - - - - - - - - - - - MORN,Pentapeptide k59_1608300_1 1410631.JHWZ01000008_gene493 1.07e-56 186.0 COG0106@1|root,COG0106@2|Bacteria,1TPIN@1239|Firmicutes,249HJ@186801|Clostridia,27IKR@186928|unclassified Lachnospiraceae 186801|Clostridia E Histidine biosynthesis protein hisA - - - - - - - - - - - His_biosynth k59_1552042_1 1121481.AUAS01000002_gene3305 6.23e-33 132.0 COG0642@1|root,COG0745@1|root,COG4251@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,4NE3J@976|Bacteroidetes,47JCX@768503|Cytophagia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_1252671_1 573370.DMR_25420 2.19e-62 207.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,42N6C@68525|delta/epsilon subdivisions,2WJ66@28221|Deltaproteobacteria,2M93K@213115|Desulfovibrionales 28221|Deltaproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_1608320_1 436308.Nmar_1078 2.24e-82 253.0 COG1830@1|root,arCOG04044@2157|Archaea,41S64@651137|Thaumarchaeota 651137|Thaumarchaeota E DeoC/LacD family aldolase - - 2.3.1.245 ko:K08321 ko02024,map02024 - - - ko00000,ko00001,ko01000 - - - DeoC k59_619644_2 1123368.AUIS01000005_gene471 2.18e-37 125.0 COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,1SCMH@1236|Gammaproteobacteria,2ND6J@225057|Acidithiobacillales 225057|Acidithiobacillales J Binds the 23S rRNA rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_309511_1 388401.RB2150_16137 2.15e-41 151.0 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,3ZHKI@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria CP COG0651 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit nuoN2 - 1.6.5.3 ko:K00343,ko:K05568 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 - - Proton_antipo_M k59_309511_2 458817.Shal_3360 3.89e-34 120.0 COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria,1S6BB@1236|Gammaproteobacteria,2QC1C@267890|Shewanellaceae 1236|Gammaproteobacteria P PFAM NADH-ubiquinone oxidoreductase chain 4L - - - ko:K05567 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Oxidored_q2 k59_1036710_2 589873.EP13_08465 2.12e-34 129.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,463Y3@72275|Alteromonadaceae 1236|Gammaproteobacteria U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltT - - ko:K03309 - - - - ko00000 2.A.23 - - SDF k59_197634_1 298386.PBPRB0644 1.23e-63 202.0 COG2221@1|root,COG2221@2|Bacteria 2|Bacteria C Nitrite and sulphite reductase 4Fe-4S napF - - ko:K02572 - - - - ko00000 - - - Fer4,Fer4_6,Fer4_7,NIR_SIR,PCP_red k59_880320_1 1121939.L861_05050 1.33e-51 176.0 COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,1RPE8@1236|Gammaproteobacteria,1XIRP@135619|Oceanospirillales 135619|Oceanospirillales G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH k59_1345767_1 565045.NOR51B_571 4.63e-54 188.0 COG1574@1|root,COG1574@2|Bacteria,1MXST@1224|Proteobacteria,1RS60@1236|Gammaproteobacteria,1J7XW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_725832_1 76114.ebA6535 2.11e-22 91.3 COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,2VRXM@28216|Betaproteobacteria,2KYQK@206389|Rhodocyclales 206389|Rhodocyclales S Aminoacyl-tRNA editing domain - - - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_725832_2 1265502.KB905959_gene257 1.92e-07 53.5 29GYT@1|root,303WG@2|Bacteria,1RET9@1224|Proteobacteria,2VT0U@28216|Betaproteobacteria,4AETB@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - DUF1269 k59_936671_1 1121948.AUAC01000002_gene1177 1.57e-100 300.0 COG1082@1|root,COG1082@2|Bacteria,1MVSJ@1224|Proteobacteria,2TV5J@28211|Alphaproteobacteria,43WUT@69657|Hyphomonadaceae 28211|Alphaproteobacteria G AP endonuclease family 2 C terminus - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N k59_566718_1 522306.CAP2UW1_4062 3.55e-41 154.0 COG4122@1|root,COG4122@2|Bacteria,1QWCT@1224|Proteobacteria,2VJBK@28216|Betaproteobacteria 28216|Betaproteobacteria S O-methyltransferase activity - - - - - - - - - - - - - k59_1036749_1 1229909.NSED_04275 5.83e-29 104.0 arCOG10548@1|root,arCOG10548@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1459774_2 925409.KI911562_gene612 1.28e-46 164.0 COG1473@1|root,COG1473@2|Bacteria,4NEKH@976|Bacteroidetes,1IRNW@117747|Sphingobacteriia 976|Bacteroidetes S Peptidase dimerisation domain - - - ko:K12941 - - - - ko00000,ko01002 - - - M20_dimer,Peptidase_M20 k59_1036750_1 1000565.METUNv1_02596 7.52e-20 86.3 COG0723@1|root,COG0723@2|Bacteria,1MZ7A@1224|Proteobacteria,2VVI5@28216|Betaproteobacteria 28216|Betaproteobacteria C plastoquinol--plastocyanin reductase activity - - - - - - - - - - - - - k59_1036750_2 65672.G4THZ9 0.000122 51.6 COG0666@1|root,KOG4177@2759|Eukaryota,3A41J@33154|Opisthokonta,3P411@4751|Fungi,3V17Y@5204|Basidiomycota,229QM@155619|Agaricomycetes,3H90J@355688|Agaricomycetes incertae sedis 4751|Fungi M Ankyrin repeat - - - - - - - - - - - - Ank,Ank_2,Ank_3,Ank_4,Ank_5 k59_776362_1 1255043.TVNIR_3482 1.54e-09 59.3 COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,1RQ6C@1236|Gammaproteobacteria,1X2KE@135613|Chromatiales 1236|Gammaproteobacteria HP ABC transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_776362_2 63577.G9P7C4 4.28e-20 90.5 COG0405@1|root,KOG2410@2759|Eukaryota,38ENY@33154|Opisthokonta,3NVWF@4751|Fungi,3QK7J@4890|Ascomycota,214ID@147550|Sordariomycetes,3TDRC@5125|Hypocreales,3TZCV@5129|Hypocreaceae 4751|Fungi E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_155039_1 1089545.KB913037_gene2294 2.18e-48 176.0 COG3696@1|root,COG3696@2|Bacteria,2I53X@201174|Actinobacteria,4EE9U@85010|Pseudonocardiales 201174|Actinobacteria P AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_199510_1 1229909.NSED_09645 5.45e-133 391.0 COG1311@1|root,arCOG04455@2157|Archaea,41T0D@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polB - 2.7.7.7 ko:K02323 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - DNA_pol_E_B k59_881790_1 547163.BN979_03685 2.68e-57 195.0 COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria,233WW@1762|Mycobacteriaceae 201174|Actinobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.42 ko:K18688 - - - - ko00000,ko01000 - - - AMP-binding,AMP-binding_C k59_985208_1 1229909.NSED_06940 9.37e-43 144.0 COG0457@1|root,arCOG03032@2157|Archaea 2157|Archaea T PFAM TPR repeat-containing protein - - - - - - - - - - - - TPR_1,TPR_19,TPR_2,TPR_8 k59_985208_2 1131266.ARWQ01000004_gene1421 8.02e-54 177.0 COG0157@1|root,arCOG01482@2157|Archaea,41SHI@651137|Thaumarchaeota 651137|Thaumarchaeota H Involved in the catabolism of quinolinic acid (QA) - - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_621558_1 222534.KB893746_gene2703 9.23e-71 229.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria 201174|Actinobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_414423_1 1380386.JIAW01000010_gene4189 2.31e-70 230.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,235TW@1762|Mycobacteriaceae 201174|Actinobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_468743_1 768671.ThimaDRAFT_0885 5.15e-27 112.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1WWPA@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase - - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_155070_1 1460635.JCM19038_2194 3.18e-76 239.0 COG4799@1|root,COG4799@2|Bacteria 2|Bacteria I CoA carboxylase activity MA20_27300 - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_776399_1 760568.Desku_3337 1.65e-77 249.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia,2613D@186807|Peptococcaceae 186801|Clostridia H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_938431_1 1242864.D187_000116 5.16e-57 197.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,42MWM@68525|delta/epsilon subdivisions,2WK3H@28221|Deltaproteobacteria,2YZNI@29|Myxococcales 28221|Deltaproteobacteria O NfeD-like C-terminal, partner-binding nfeD - - ko:K07403 - - - - ko00000 - - - CLP_protease,NfeD,SDH_sah k59_1402941_1 1499967.BAYZ01000073_gene2049 7.36e-19 91.7 COG3119@1|root,COG3119@2|Bacteria,2NR0Q@2323|unclassified Bacteria 2|Bacteria P Sulfatase - - - - - - - - - - - - CBM60,Sulfatase k59_1347619_1 1089551.KE386572_gene4430 6.3e-96 297.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,4BPEA@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Electron transfer flavoprotein-ubiquinone oxidoreductase etf - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_1347621_1 519989.ECTPHS_10466 1.09e-55 187.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WW5M@135613|Chromatiales 135613|Chromatiales EH Anthranilate synthase component I - - 2.6.1.85,4.1.3.27 ko:K01657,ko:K01665 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1347621_2 765913.ThidrDRAFT_0574 8.71e-21 89.7 COG2054@1|root,COG2054@2|Bacteria,1MZY4@1224|Proteobacteria,1S9PH@1236|Gammaproteobacteria,1X0ZK@135613|Chromatiales 135613|Chromatiales H Amino acid kinase family - - - - - - - - - - - - AA_kinase k59_1553984_2 436308.Nmar_0782 2.64e-56 175.0 COG2343@1|root,arCOG06569@2157|Archaea 2157|Archaea S Domain of unknown function (DUF427) - - - - - - - - - - - - NTP_transf_9 k59_311307_2 326424.FRAAL0762 0.000636 41.6 COG1028@1|root,COG1028@2|Bacteria,2GJIH@201174|Actinobacteria 201174|Actinobacteria IQ Dehydrogenase xecD - - - - - - - - - - - adh_short_C2 k59_1191442_1 697282.Mettu_1388 2.65e-86 270.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1XDYT@135618|Methylococcales 135618|Methylococcales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1191442_2 35841.BT1A1_0631 4.84e-20 84.0 COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,4HNNA@91061|Bacilli,1ZH54@1386|Bacillus 91061|Bacilli J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_468783_1 1121439.dsat_0484 5.01e-102 309.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42NUK@68525|delta/epsilon subdivisions,2WKP4@28221|Deltaproteobacteria,2M9ZG@213115|Desulfovibrionales 28221|Deltaproteobacteria M MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_363076_1 1382356.JQMP01000001_gene805 2.28e-62 208.0 COG0146@1|root,COG0146@2|Bacteria,2G644@200795|Chloroflexi,27XUU@189775|Thermomicrobia 189775|Thermomicrobia EQ PFAM Hydantoinase B oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_1148346_1 983545.Glaag_0096 1.58e-91 281.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,46537@72275|Alteromonadaceae 1236|Gammaproteobacteria I Biotin carboxylase accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iSF_1195.SF3294 Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_994366_1 179408.Osc7112_2732 5.43e-116 350.0 COG1249@1|root,COG1249@2|Bacteria,1G198@1117|Cyanobacteria,1H7PH@1150|Oscillatoriales 1117|Cyanobacteria C Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase merA - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_1464990_1 998674.ATTE01000001_gene2601 8.02e-50 172.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,460AU@72273|Thiotrichales 72273|Thiotrichales L TIGRFAM A G-specific adenine glycosylase - - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_1204168_1 1547437.LL06_01360 9.9e-81 245.0 COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2TSEW@28211|Alphaproteobacteria,43H32@69277|Phyllobacteriaceae 28211|Alphaproteobacteria CO periplasmic protein thiol disulfide cycY - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA,Redoxin k59_576679_2 298655.KI912266_gene5171 3.77e-06 51.6 COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4EREM@85013|Frankiales 201174|Actinobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - HHH_5,IMS,IMS_C,IMS_HHH k59_55011_1 1038858.AXBA01000024_gene4072 2.31e-35 140.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2TVQR@28211|Alphaproteobacteria,3EZZS@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Patatin-like phospholipase rssA GO:0003674,GO:0003824,GO:0016787 - ko:K07001 - - - - ko00000 - - - Patatin k59_1204189_1 1157708.KB907450_gene5812 5.71e-34 129.0 2A20V@1|root,30QAU@2|Bacteria,1RDQH@1224|Proteobacteria,2VQZV@28216|Betaproteobacteria,4ADSI@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1099348_1 448385.sce5871 2.41e-119 377.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,2YX1T@29|Myxococcales 28221|Deltaproteobacteria H Methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_1621620_3 351348.Maqu_4285 7.84e-36 143.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,1RQ34@1236|Gammaproteobacteria,466BB@72275|Alteromonadaceae 1236|Gammaproteobacteria L SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,Mrr_cat,SNF2_N k59_786289_1 755178.Cyan10605_1596 1.88e-16 86.7 COG0517@1|root,COG2202@1|root,COG2203@1|root,COG3920@1|root,COG0517@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3920@2|Bacteria,1GQ5I@1117|Cyanobacteria 1117|Cyanobacteria T Diguanylate cyclase with PAS PAC and GAF sensors - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - CBS,EAL,GAF,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_106419_1 222534.KB893738_gene1271 2.64e-09 62.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,2GNEI@201174|Actinobacteria 201174|Actinobacteria IQ Rhamnulose-1-phosphate aldolase alcohol dehydrogenase rhaD - 1.1.1.1,1.1.1.140,4.1.2.19 ko:K00001,ko:K00068,ko:K01629 ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R01785,R02124,R02263,R04805,R04880,R05233,R05234,R05607,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00085,RC00087,RC00088,RC00099,RC00116,RC00438,RC00599,RC00603,RC00604,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Aldolase_II,adh_short,adh_short_C2 k59_1256347_1 519989.ECTPHS_04980 8.74e-151 444.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1WXIB@135613|Chromatiales 135613|Chromatiales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1256347_2 292415.Tbd_1108 4.9e-10 59.7 COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,2VQUX@28216|Betaproteobacteria 28216|Betaproteobacteria C Protein of unknown function (DUF3501) - - - - - - - - - - - - DUF3501 k59_315808_1 857293.CAAU_2096 1.71e-68 222.0 COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,36DPK@31979|Clostridiaceae 186801|Clostridia H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K01598,ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_942252_1 1469245.JFBG01000027_gene1469 3.98e-98 294.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1WW7F@135613|Chromatiales 135613|Chromatiales EP PFAM Binding-protein-dependent transport - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1307865_1 105559.Nwat_2674 9.22e-35 133.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales 135613|Chromatiales Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_942257_1 504832.OCAR_6737 4.82e-76 239.0 COG0045@1|root,COG0045@2|Bacteria,1R3UY@1224|Proteobacteria,2TVQC@28211|Alphaproteobacteria,3JX19@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Belongs to the succinate malate CoA ligase beta subunit family - - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_1204224_1 379066.GAU_3472 1.56e-48 169.0 COG0577@1|root,COG0577@2|Bacteria,1ZSU3@142182|Gemmatimonadetes 2|Bacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1256361_1 522373.Smlt0842 3.68e-74 236.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1X4AP@135614|Xanthomonadales 135614|Xanthomonadales J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 k59_890446_1 1382315.JPOI01000001_gene1404 7.62e-40 148.0 COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HACS@91061|Bacilli,1WE26@129337|Geobacillus 91061|Bacilli H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily menE - 6.2.1.26 ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C k59_106434_1 1379270.AUXF01000004_gene3319 4.42e-69 225.0 COG2204@1|root,COG2204@2|Bacteria,1ZSZ6@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1412343_2 187272.Mlg_0934 3.92e-23 97.8 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,1WWKI@135613|Chromatiales 135613|Chromatiales G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB - - ko:K19804 - - - - ko00000 - - - TPR_16,TPR_7 k59_1360535_1 1182590.BN5_00411 1.21e-67 218.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1YEV5@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355 Ubie_methyltran k59_1360535_2 713586.KB900536_gene2188 6.35e-51 164.0 COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1S8TB@1236|Gammaproteobacteria,1WYD9@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF971) - - - - - - - - - - - - DUF971 k59_106440_1 395493.BegalDRAFT_0650 7.36e-45 162.0 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RNQ2@1236|Gammaproteobacteria,45ZVA@72273|Thiotrichales 72273|Thiotrichales GM Polysaccharide biosynthesis protein wbtA - - - - - - - - - - - CoA_binding_3,Polysacc_synt_2 k59_472025_1 748280.NH8B_2766 7.3e-173 528.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2VI8X@28216|Betaproteobacteria 28216|Betaproteobacteria L DEAD DEAH box helicase lhr - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_1412353_1 330214.NIDE3236 1.86e-08 54.3 COG1140@1|root,COG1140@2|Bacteria,3J1FU@40117|Nitrospirae 2|Bacteria C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology ddhB GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.5.1 ko:K00371,ko:K16965,ko:K17048,ko:K17051 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 - - Fer4_11 k59_1360545_2 1211114.ALIP01000091_gene2845 2.76e-09 57.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1X3PC@135614|Xanthomonadales 135614|Xanthomonadales C acetyltransferase component of pyruvate dehydrogenase complex aceF - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_681912_1 393595.ABO_1041 2.42e-47 166.0 COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,1XIQ4@135619|Oceanospirillales 135619|Oceanospirillales S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1204247_2 1254432.SCE1572_52485 4.06e-59 196.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42M5U@68525|delta/epsilon subdivisions,2WJ06@28221|Deltaproteobacteria 28221|Deltaproteobacteria H MoeA domain protein domain I and II - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1100055_2 479434.Sthe_3442 1.73e-134 389.0 COG0451@1|root,COG0451@2|Bacteria,2G64F@200795|Chloroflexi,27XSM@189775|Thermomicrobia 2|Bacteria GM 3-beta hydroxysteroid dehydrogenase/isomerase family - - - - - - - - - - - - Epimerase k59_1465761_1 316067.Geob_2998 2.11e-17 79.0 COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,42W4B@68525|delta/epsilon subdivisions,2WP0P@28221|Deltaproteobacteria,43UMI@69541|Desulfuromonadales 28221|Deltaproteobacteria S TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - 5.4.2.6 ko:K01838 ko00500,map00500 - R02728,R11310 RC00408 ko00000,ko00001,ko01000 - - - HAD_2 k59_472658_3 398767.Glov_0401 5.7e-36 126.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,42RVK@68525|delta/epsilon subdivisions,2WNNA@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_1465765_1 1201293.AKXQ01000002_gene1798 5.98e-05 45.8 COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,1S72P@1236|Gammaproteobacteria 1236|Gammaproteobacteria H molybdopterin-guanine dinucleotide biosynthesis protein mobB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.7.7.77 ko:K03753,ko:K13818 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - iB21_1397.B21_03691,iBWG_1329.BWG_3527,iECBD_1354.ECBD_4174,iECDH1ME8569_1439.ECDH1ME8569_3728,iEcDH1_1363.EcDH1_4130,iJO1366.b3856,iSbBS512_1146.SbBS512_E4328,iY75_1357.Y75_RS17805 MobB k59_1465765_2 2340.JV46_12800 9.37e-44 156.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1J533@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H MoeA N-terminal region (domain I and II) moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MobB,MoeA_C,MoeA_N k59_211918_1 1167006.UWK_02226 2.54e-50 172.0 COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,42M9Y@68525|delta/epsilon subdivisions,2WM8Z@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PFAM sodium hydrogen exchanger - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger k59_55903_1 1273711.A0A096VKE2_9CAUD 2.78e-61 195.0 4QAM2@10239|Viruses,4QV3W@35237|dsDNA viruses no RNA stage,4QPGK@28883|Caudovirales,4QNW0@10744|Podoviridae 10744|Podoviridae S exonuclease activity - GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 - - - - - - - - - - - k59_525300_2 269799.Gmet_0588 3.25e-10 66.6 COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria,43TXB@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8 k59_55912_1 309801.trd_A0816 5.5e-38 144.0 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2G66B@200795|Chloroflexi,27XNK@189775|Thermomicrobia 189775|Thermomicrobia M PFAM sugar transferase - - - - - - - - - - - - Bac_transf,CoA_binding_3 k59_316595_1 523791.Kkor_1770 2.1e-63 210.0 COG2978@1|root,COG2978@2|Bacteria,1MUJ1@1224|Proteobacteria,1RMAI@1236|Gammaproteobacteria,1XHHG@135619|Oceanospirillales 135619|Oceanospirillales H transporter ydaH - - ko:K12942 - - - - ko00000 - - - ABG_transport k59_55917_1 1045855.DSC_09115 1.28e-14 78.6 COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria,1X49B@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate - - 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_55918_1 323261.Noc_1582 3.8e-74 245.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,1WVWD@135613|Chromatiales 135613|Chromatiales C PFAM malic - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_1047731_1 470145.BACCOP_01172 5.52e-27 115.0 COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria,4P0VD@976|Bacteroidetes,2FMKK@200643|Bacteroidia,4AMUT@815|Bacteroidaceae 976|Bacteroidetes L Psort location Cytoplasmic, score 8.96 - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,DnaB_C,Toprim_2,Toprim_4 k59_368770_1 1395571.TMS3_0115075 8.7e-73 229.0 COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,1RYFV@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Mandelate Racemase Muconate Lactonizing - - 4.2.1.156,4.2.1.42,5.1.2.2,5.5.1.25 ko:K01781,ko:K20023,ko:K20549 ko00053,ko00627,ko01120,map00053,map00627,map01120 - R03791,R04161,R05608 RC00543,RC00998 ko00000,ko00001,ko01000 - - - MR_MLE_C,MR_MLE_N k59_368770_2 1380358.JADJ01000003_gene4706 6.77e-28 102.0 2E5W4@1|root,330K6@2|Bacteria,1N893@1224|Proteobacteria 1224|Proteobacteria S NIPSNAP family containing protein - - - - - - - - - - - - NIPSNAP k59_107105_1 1354722.JQLS01000008_gene1167 4.36e-16 77.0 COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2TVHI@28211|Alphaproteobacteria,46RDK@74030|Roseovarius 28211|Alphaproteobacteria C Cytochrome D1 heme domain nirN - - - - - - - - - - - Cytochrom_D1,Cytochrome_CBB3 k59_1151923_1 204669.Acid345_1271 1.31e-25 109.0 COG1233@1|root,COG1233@2|Bacteria,3Y3I8@57723|Acidobacteria,2JI78@204432|Acidobacteriia 204432|Acidobacteriia C TIGRFAM phytoene desaturase - - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 - R04787,R04798,R04800,R09691,R09692 RC01214,RC02088,RC02605 ko00000,ko00001,ko01000 - - - Amino_oxidase k59_420904_1 1048339.KB913029_gene4240 2.31e-25 113.0 COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,2GIZP@201174|Actinobacteria,4ERSV@85013|Frankiales 201174|Actinobacteria I Acetyl-CoA carboxylase, central region - - - - - - - - - - - - ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans k59_525310_1 338966.Ppro_2143 8.8e-26 102.0 COG1371@1|root,COG1371@2|Bacteria,1NMZF@1224|Proteobacteria,42X9A@68525|delta/epsilon subdivisions,2WSP3@28221|Deltaproteobacteria,43V4V@69541|Desulfuromonadales 28221|Deltaproteobacteria S Archease protein family (MTH1598/TM1083) - - - - - - - - - - - - Archease k59_316604_1 83406.HDN1F_02600 2.4e-09 58.5 COG1028@1|root,COG1028@2|Bacteria,1MXVZ@1224|Proteobacteria,1RRUK@1236|Gammaproteobacteria,1J5NX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_316604_2 1449976.KALB_2441 1.1e-55 184.0 COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria,4E07A@85010|Pseudonocardiales 201174|Actinobacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_1622346_1 1437824.BN940_09461 2.99e-25 109.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2VHBY@28216|Betaproteobacteria,3T1P5@506|Alcaligenaceae 28216|Betaproteobacteria E Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_787202_1 279714.FuraDRAFT_3773 7.58e-111 334.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2VMU1@28216|Betaproteobacteria,2KS2V@206351|Neisseriales 206351|Neisseriales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_107148_1 870187.Thini_0878 9.9e-81 249.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,460H9@72273|Thiotrichales 72273|Thiotrichales O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group cyoE - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_211979_1 1469245.JFBG01000036_gene1966 7.81e-68 217.0 COG3180@1|root,COG3180@2|Bacteria,1MUFS@1224|Proteobacteria,1RPMJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Ammonia monooxygenase abrB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07120 - - - - ko00000 - - - AbrB k59_734364_1 247490.KSU1_D0195 1.6e-84 263.0 COG1032@1|root,COG1032@2|Bacteria,2IXHH@203682|Planctomycetes 203682|Planctomycetes C Domain of unknown function (DUF4070) - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_1488805_1 981223.AIED01000027_gene19 1.39e-50 170.0 COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,1RMYN@1236|Gammaproteobacteria,3NMCR@468|Moraxellaceae 1236|Gammaproteobacteria M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_495398_1 215803.DB30_7621 0.000631 45.1 COG0747@1|root,COG5492@1|root,COG0747@2|Bacteria,COG5492@2|Bacteria,1QX9G@1224|Proteobacteria,43C2P@68525|delta/epsilon subdivisions,2X7D9@28221|Deltaproteobacteria,2Z3FQ@29|Myxococcales 28221|Deltaproteobacteria E Fungalysin metallopeptidase (M36) - - - - - - - - - - - - FTP,PA,Peptidase_M36,REJ k59_229683_1 1056820.KB900663_gene3824 2.26e-57 199.0 COG1858@1|root,COG1858@2|Bacteria,1QVCJ@1224|Proteobacteria,1T31G@1236|Gammaproteobacteria,2PQ7W@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P cytochrome C peroxidase - - - - - - - - - - - - - k59_542693_1 710696.Intca_3005 9.01e-40 146.0 COG1290@1|root,COG1290@2|Bacteria,2ICE4@201174|Actinobacteria 201174|Actinobacteria C Cytochrome b/b6/petB - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_N_2 k59_654173_1 391625.PPSIR1_40300 4.18e-39 137.0 COG4445@1|root,COG4445@2|Bacteria,1MVFE@1224|Proteobacteria,439JD@68525|delta/epsilon subdivisions,2X4VZ@28221|Deltaproteobacteria,2YZQ9@29|Myxococcales 28221|Deltaproteobacteria FJ tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) - - - ko:K06169 - - - - ko00000,ko01000,ko03016 - - - MiaE k59_654173_2 1120973.AQXL01000111_gene936 9.03e-61 197.0 COG0667@1|root,COG0667@2|Bacteria,1TRS0@1239|Firmicutes,4HBX5@91061|Bacilli,279G5@186823|Alicyclobacillaceae 91061|Bacilli C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_1066054_1 530564.Psta_3916 3.41e-41 150.0 COG0265@1|root,COG0265@2|Bacteria,2IXAW@203682|Planctomycetes 203682|Planctomycetes O typically periplasmic contain C-terminal PDZ domain - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1013204_1 331869.BAL199_27356 4.33e-21 89.7 COG5285@1|root,COG5285@2|Bacteria,1R6VR@1224|Proteobacteria,2U42H@28211|Alphaproteobacteria,4BQR5@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q Phytanoyl-CoA dioxygenase (PhyH) - - - - - - - - - - - - PhyH k59_1013204_2 1395571.TMS3_0115075 2.05e-38 139.0 COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,1RYFV@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Mandelate Racemase Muconate Lactonizing - - 4.2.1.156,4.2.1.42,5.1.2.2,5.5.1.25 ko:K01781,ko:K20023,ko:K20549 ko00053,ko00627,ko01120,map00053,map00627,map01120 - R03791,R04161,R05608 RC00543,RC00998 ko00000,ko00001,ko01000 - - - MR_MLE_C,MR_MLE_N k59_1066900_1 338963.Pcar_3001 3.13e-126 390.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WJ2A@28221|Deltaproteobacteria,43SE5@69541|Desulfuromonadales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_1167965_1 765914.ThisiDRAFT_2315 8.98e-45 163.0 COG0187@1|root,COG1372@1|root,COG0187@2|Bacteria,COG1372@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1167965_2 1177154.Y5S_02233 4.31e-39 133.0 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1XKH7@135619|Oceanospirillales 135619|Oceanospirillales P protein affecting Mg2 Co2 transport apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_1379492_1 643867.Ftrac_2071 5.04e-91 284.0 COG0213@1|root,COG0213@2|Bacteria,4NFVB@976|Bacteroidetes,47U8B@768503|Cytophagia 976|Bacteroidetes F Glycosyl transferase family, helical bundle domain - - 2.4.2.2,2.4.2.4 ko:K00756,ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R01876,R02296,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C k59_496510_2 648757.Rvan_2270 3.19e-08 53.1 COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,2U9BQ@28211|Alphaproteobacteria,3N733@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_1324365_1 1122931.AUAE01000040_gene2809 1.11e-18 91.3 COG1453@1|root,COG1453@2|Bacteria,4P07C@976|Bacteroidetes,2FRKN@200643|Bacteroidia,22YVY@171551|Porphyromonadaceae 976|Bacteroidetes S Aldo/keto reductase family - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red,Fer4_17 k59_80666_2 665029.EAMY_0983 1.9e-67 210.0 COG0740@1|root,COG0740@2|Bacteria,1RBNX@1224|Proteobacteria,1S4TV@1236|Gammaproteobacteria,3X67C@551|Erwinia 1236|Gammaproteobacteria OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP2 - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_857807_1 246197.MXAN_0979 6.89e-92 294.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2YTUI@29|Myxococcales 28221|Deltaproteobacteria P copper-translocating P-type ATPase copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_1643128_1 765912.Thimo_1071 4.29e-154 446.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1WWNX@135613|Chromatiales 135613|Chromatiales E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_1643128_2 29581.BW37_03300 3.16e-09 54.7 COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,2VU39@28216|Betaproteobacteria,474U5@75682|Oxalobacteraceae 28216|Betaproteobacteria S MazG-like family - - - - - - - - - - - - MazG-like k59_655340_2 525904.Tter_0436 1.36e-36 129.0 COG1490@1|root,COG1490@2|Bacteria,2NPJK@2323|unclassified Bacteria 2|Bacteria J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_857808_1 373903.Hore_08450 3.54e-07 57.4 COG1033@1|root,COG1033@2|Bacteria,1VSWA@1239|Firmicutes,247R6@186801|Clostridia,3WB6E@53433|Halanaerobiales 186801|Clostridia S hydrophobe amphiphile efflux-3 (HAE3) family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1436253_1 216142.LT40_10770 9.34e-60 198.0 COG2270@1|root,COG2270@2|Bacteria,1QV57@1224|Proteobacteria,1T28V@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Major Facilitator - - - - - - - - - - - - Nuc_H_symport k59_596327_1 518766.Rmar_1618 3.97e-30 121.0 COG0682@1|root,COG0682@2|Bacteria,4NGSG@976|Bacteroidetes 976|Bacteroidetes M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_596327_2 1095743.HMPREF1054_1496 1.88e-14 74.3 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1Y794@135625|Pasteurellales 135625|Pasteurellales P Trk system potassium uptake protein TrkA trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_1324379_1 649747.HMPREF0083_05276 6.05e-11 64.7 COG0306@1|root,COG0306@2|Bacteria,1TQ3D@1239|Firmicutes,4HAPD@91061|Bacilli,26TZ5@186822|Paenibacillaceae 91061|Bacilli P Phosphate transporter family cysP - - ko:K16331 - - - - ko00000,ko02000 2.A.20.4 - - PHO4 k59_283377_1 269796.Rru_A1605 1.94e-36 142.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria,2JREK@204441|Rhodospirillales 204441|Rhodospirillales G Maltogenic Amylase, C-terminal domain - - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - APH,Alpha-amylase,Malt_amylase_C k59_80685_1 63737.Npun_R1768 4.93e-35 144.0 COG0841@1|root,COG0841@2|Bacteria,1G0C2@1117|Cyanobacteria 1117|Cyanobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_655361_1 862908.BMS_1112 1.08e-40 149.0 COG0477@1|root,COG2814@2|Bacteria,1R590@1224|Proteobacteria,42P8I@68525|delta/epsilon subdivisions,2WKQ6@28221|Deltaproteobacteria 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_857827_1 765913.ThidrDRAFT_2752 2.3e-48 171.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1WWSQ@135613|Chromatiales 135613|Chromatiales M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_1588622_1 511680.BUTYVIB_02061 1.19e-28 116.0 COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,4BXD3@830|Butyrivibrio 186801|Clostridia IQ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1588622_2 981085.XP_010104603.1 1e-06 49.7 COG0236@1|root,KOG1748@2759|Eukaryota,37VQW@33090|Viridiplantae,3GJPC@35493|Streptophyta,4JPYH@91835|fabids 35493|Streptophyta CIQ Acyl carrier protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - PP-binding k59_175064_1 246196.MSMEI_0647 3.96e-11 68.9 COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,234PD@1762|Mycobacteriaceae 201174|Actinobacteria Q NAD(P)-binding Rossmann-like domain - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_702769_1 502025.Hoch_5539 1.61e-143 424.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WIQG@28221|Deltaproteobacteria,2YUFQ@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1,6.2.1.16 ko:K01895,ko:K01907 ko00010,ko00280,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00280,map00620,map00640,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354,R01357 RC00004,RC00012,RC00014,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1490056_1 269799.Gmet_1364 1.1e-12 65.1 COG1014@1|root,COG1014@2|Bacteria,1RAQ4@1224|Proteobacteria,43BEE@68525|delta/epsilon subdivisions,2WN0D@28221|Deltaproteobacteria,43TV8@69541|Desulfuromonadales 28221|Deltaproteobacteria C PFAM pyruvate ferredoxin flavodoxin oxidoreductase korC - 1.2.7.3 ko:K00177 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR k59_1490056_2 1158318.ATXC01000001_gene195 9.29e-70 221.0 COG1013@1|root,COG1013@2|Bacteria,2G42W@200783|Aquificae 200783|Aquificae C TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_1226892_2 330214.NIDE0780 1.9e-56 186.0 COG1947@1|root,COG1947@2|Bacteria,3J0N1@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_857839_1 1429916.X566_09735 2.34e-93 286.0 COG2141@1|root,COG2141@2|Bacteria,1NX0H@1224|Proteobacteria,2U42F@28211|Alphaproteobacteria,3K6H5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_857839_2 1429916.X566_09740 6.29e-82 253.0 COG0596@1|root,COG0596@2|Bacteria,1R2M3@1224|Proteobacteria,2TZN8@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Serine aminopeptidase, S33 - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_6 k59_230580_1 1380391.JIAS01000016_gene437 3.02e-06 52.8 COG0697@1|root,COG0697@2|Bacteria,1RCED@1224|Proteobacteria,2U66Q@28211|Alphaproteobacteria,2JRZ1@204441|Rhodospirillales 204441|Rhodospirillales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_910215_1 998674.ATTE01000001_gene673 9.37e-97 285.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,45ZYA@72273|Thiotrichales 72273|Thiotrichales OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_440717_1 251229.Chro_4406 6.48e-29 112.0 COG0167@1|root,COG0167@2|Bacteria,1G2B6@1117|Cyanobacteria,3VJ02@52604|Pleurocapsales 1117|Cyanobacteria F Catalyzes the conversion of dihydroorotate to orotate - - 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_80726_1 472759.Nhal_0595 1.73e-129 386.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1WW7K@135613|Chromatiales 135613|Chromatiales T GTP-binding protein TypA - - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_335817_1 865861.AZSU01000002_gene3150 4.91e-58 196.0 COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,36EI0@31979|Clostridiaceae 186801|Clostridia F Belongs to the formate--tetrahydrofolate ligase family fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_175080_1 317655.Sala_1031 2.62e-28 116.0 COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2TVJ5@28211|Alphaproteobacteria,2K04D@204457|Sphingomonadales 204457|Sphingomonadales S Peptidase, M28 - - - - - - - - - - - - PA,Peptidase_M28 k59_335819_1 748247.AZKH_1502 4.77e-83 258.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,2KUWF@206389|Rhodocyclales 28216|Betaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_389955_1 765913.ThidrDRAFT_0916 1.54e-117 357.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1WWXP@135613|Chromatiales 135613|Chromatiales J small GTP-binding protein - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_1226913_1 620914.JH621251_gene2316 8.15e-19 95.1 COG2373@1|root,COG3420@1|root,COG4932@1|root,COG2373@2|Bacteria,COG3420@2|Bacteria,COG4932@2|Bacteria,4PNM0@976|Bacteroidetes,1IK8U@117743|Flavobacteriia,2YM5U@290174|Aquimarina 976|Bacteroidetes P Right handed beta helix region - - - - - - - - - - - - Beta_helix k59_440740_1 1120977.JHUX01000004_gene2202 3.3e-56 189.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RV50@1236|Gammaproteobacteria,3NJER@468|Moraxellaceae 1236|Gammaproteobacteria I Belongs to the thiolase family fadA - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1324421_1 1276229.SSYRP_v1c07840 8.01e-11 65.9 COG1131@1|root,COG1131@2|Bacteria,3WT59@544448|Tenericutes 544448|Tenericutes V abc transporter atp-binding protein - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1066992_1 330214.NIDE1955 4.05e-31 122.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria 2|Bacteria S CHAT domain - - - - - - - - - - - - CHAT,TPR_10,TPR_12,TPR_16,TPR_7,TPR_8 k59_1436337_1 933262.AXAM01000003_gene2804 2.18e-33 123.0 COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,42R30@68525|delta/epsilon subdivisions,2WJT0@28221|Deltaproteobacteria,2MJ3P@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_910246_1 980584.AFPB01000072_gene1345 1.27e-82 261.0 COG0577@1|root,COG0577@2|Bacteria,4NEBD@976|Bacteroidetes,1IIKD@117743|Flavobacteriia 976|Bacteroidetes V ABC transporter, permease protein - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1436354_1 436308.Nmar_1693 1.82e-90 285.0 COG1269@1|root,arCOG04138@2157|Archaea,41SRH@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_702814_1 553218.CAMRE0001_1648 2.83e-28 115.0 COG1495@1|root,COG1495@2|Bacteria 2|Bacteria O protein disulfide oxidoreductase activity - - - ko:K03611 - - - - ko00000,ko03110 5.A.2.1 - - DsbB k59_655461_1 65093.PCC7418_1450 7.84e-84 278.0 COG0474@1|root,COG0474@2|Bacteria,1G0JX@1117|Cyanobacteria 1117|Cyanobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_1168040_1 396588.Tgr7_2153 2.09e-116 349.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1WWU2@135613|Chromatiales 135613|Chromatiales E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_283463_1 232721.Ajs_2161 3.2e-50 176.0 COG0637@1|root,COG1877@1|root,COG0637@2|Bacteria,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2VRQ8@28216|Betaproteobacteria,4ADUM@80864|Comamonadaceae 28216|Betaproteobacteria G Removes the phosphate from trehalose 6-phosphate to produce free trehalose - - 3.1.3.12 ko:K01087 ko00500,ko01100,map00500,map01100 - R02778 RC00017 ko00000,ko00001,ko01000 - - - Trehalose_PPase k59_1436362_1 1313265.JNIE01000004_gene436 1.1e-69 223.0 COG0112@1|root,COG0112@2|Bacteria,2G3J7@200783|Aquificae 200783|Aquificae E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_1436362_2 747365.Thena_0430 4.66e-05 44.7 COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,42GC5@68295|Thermoanaerobacterales 186801|Clostridia G ribose 5-phosphate isomerase B rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_857892_1 1229909.NSED_09905 1.74e-75 244.0 COG1293@1|root,arCOG01695@2157|Archaea,41SB0@651137|Thaumarchaeota 651137|Thaumarchaeota K Fibronectin-binding protein A N-terminus (FbpA) - - - - - - - - - - - - DUF814,FbpA k59_1282516_1 1123320.KB889585_gene1895 6e-124 366.0 COG1960@1|root,COG1960@2|Bacteria,2ICK3@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1498433_1 313603.FB2170_04140 1.02e-111 335.0 COG1858@1|root,COG1858@2|Bacteria,4NJ4X@976|Bacteroidetes,1I05W@117743|Flavobacteriia 976|Bacteroidetes P cytochrome C peroxidase - - - - - - - - - - - - - k59_708844_1 998088.B565_2054 5.99e-87 287.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1Y44E@135624|Aeromonadales 135624|Aeromonadales L Helicase associated domain (HA2) Add an annotation hrpA - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_1234684_1 1541065.JRFE01000023_gene3778 3.3e-05 50.8 2E63H@1|root,330SK@2|Bacteria,1G9PE@1117|Cyanobacteria 1117|Cyanobacteria S PFAM Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_1 k59_1234685_1 986075.CathTA2_1979 2.39e-85 263.0 COG0045@1|root,COG0045@2|Bacteria,1TQG4@1239|Firmicutes,4HA3W@91061|Bacilli 91061|Bacilli C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_967535_2 2340.JV46_15090 4.06e-67 217.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,1J4X6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063,iJN746.PP_4889 Adenylsucc_synt k59_917236_1 998088.B565_0757 7.57e-79 245.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1Y46X@135624|Aeromonadales 135624|Aeromonadales H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_342608_1 713587.THITH_03235 9.24e-76 247.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S TRAP transporter, 4TM 12TM fusion protein - - - - - - - - - - - - DctM k59_180309_1 1192034.CAP_1697 1.33e-27 118.0 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,42QG6@68525|delta/epsilon subdivisions,2WNNB@28221|Deltaproteobacteria 28221|Deltaproteobacteria V TIGRFAM MATE efflux family protein norM - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_602462_1 748247.AZKH_p0222 2.87e-84 262.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria,2KX8V@206389|Rhodocyclales 206389|Rhodocyclales L Group II intron, maturase-specific domain - - - - - - - - - - - - GIIM,RVT_1 k59_1125968_1 1410620.SHLA_2c000580 3.01e-16 83.6 COG4177@1|root,COG4177@2|Bacteria,1MWRD@1224|Proteobacteria,2TS03@28211|Alphaproteobacteria,4BFYI@82115|Rhizobiaceae 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01998,ko:K11961 ko02010,ko02024,map02010,map02024 M00237,M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4,3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_1125969_1 5017.XP_007710396.1 4.51e-39 141.0 COG0491@1|root,KOG0813@2759|Eukaryota,38BZ4@33154|Opisthokonta,3P10J@4751|Fungi,3QKGV@4890|Ascomycota,1ZXW2@147541|Dothideomycetes,4KB4K@92860|Pleosporales 4751|Fungi S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_88898_1 56780.SYN_00622 1.81e-13 77.0 COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,1PDZS@1224|Proteobacteria,437Y5@68525|delta/epsilon subdivisions,2X1XX@28221|Deltaproteobacteria,2MS9J@213462|Syntrophobacterales 28221|Deltaproteobacteria G Trehalose-phosphatase - - 2.4.1.15,3.1.3.12 ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Trehalose_PPase k59_1173473_1 748658.KB907312_gene1791 2.09e-85 267.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1WWNX@135613|Chromatiales 135613|Chromatiales E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_88906_2 1229909.NSED_08155 8.76e-40 140.0 COG0214@1|root,arCOG04075@2157|Archaea,41SEJ@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the PdxS SNZ family - - 4.3.3.6 ko:K06215 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SOR_SNZ k59_395221_1 580332.Slit_0395 2.32e-124 368.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2VHS1@28216|Betaproteobacteria,44V6S@713636|Nitrosomonadales 28216|Betaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_395221_2 1121106.JQKB01000060_gene4891 1.3e-14 72.8 COG3387@1|root,COG3387@2|Bacteria,1MYVI@1224|Proteobacteria,2TVIW@28211|Alphaproteobacteria,2JVYZ@204441|Rhodospirillales 204441|Rhodospirillales G Glucodextranase, domain N - - - - - - - - - - - - Glucodextran_N,Glyco_hydro_15 k59_1329817_1 395493.BegalDRAFT_1741 9.19e-69 215.0 COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria,460G3@72273|Thiotrichales 72273|Thiotrichales Q ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_602471_1 485918.Cpin_3938 9.25e-61 198.0 COG0388@1|root,COG0388@2|Bacteria,4NEME@976|Bacteroidetes,1IPIY@117747|Sphingobacteriia 976|Bacteroidetes S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase pabB - 3.5.1.53,3.5.1.6 ko:K01431,ko:K12251 ko00240,ko00330,ko00410,ko00770,ko00983,ko01100,map00240,map00330,map00410,map00770,map00983,map01100 M00046 R00905,R01152,R04666,R08228 RC00096 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase k59_549757_1 269799.Gmet_1848 6.07e-74 236.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,42MSB@68525|delta/epsilon subdivisions,2WJI6@28221|Deltaproteobacteria,43TW2@69541|Desulfuromonadales 28221|Deltaproteobacteria J Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_395229_1 1121396.KB893096_gene3536 1.18e-70 227.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2WJ3T@28221|Deltaproteobacteria,2MHMX@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1073923_1 1216976.AX27061_3674 1.22e-12 76.3 COG0421@1|root,COG0421@2|Bacteria,1QY0T@1224|Proteobacteria,2WH8S@28216|Betaproteobacteria,3T9JQ@506|Alcaligenaceae 28216|Betaproteobacteria E Spermidine synthase - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_88930_1 1232410.KI421424_gene1679 6.3e-77 244.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2WJ5H@28221|Deltaproteobacteria,43RY6@69541|Desulfuromonadales 28221|Deltaproteobacteria F IMP dehydrogenase / GMP reductase domain guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_664010_2 472759.Nhal_2673 2.42e-51 183.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales 135613|Chromatiales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon k59_821074_1 589924.Ferp_1439 8.32e-06 47.8 arCOG12382@1|root,arCOG12382@2157|Archaea,2Y3JR@28890|Euryarchaeota,2470X@183980|Archaeoglobi 183980|Archaeoglobi - - - - - - - - - - - - - - - k59_917309_1 743720.Psefu_3555 4.22e-53 182.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,1YX7Q@136845|Pseudomonas putida group 1236|Gammaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_864039_1 1267535.KB906767_gene896 2.62e-16 76.6 COG0745@1|root,COG0745@2|Bacteria,3Y4FA@57723|Acidobacteria,2JJ3P@204432|Acidobacteriia 204432|Acidobacteriia T response regulator, receiver - - - - - - - - - - - - Response_reg,Trans_reg_C k59_864039_2 1205680.CAKO01000040_gene831 2.94e-19 89.7 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2TR46@28211|Alphaproteobacteria,2JQBI@204441|Rhodospirillales 204441|Rhodospirillales T signal transduction histidine kinase phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_4,PAS_8 k59_1126013_1 1415754.JQMK01000013_gene127 1.01e-09 62.4 COG0394@1|root,COG0640@1|root,COG0394@2|Bacteria,COG0640@2|Bacteria,1MZT1@1224|Proteobacteria,1SAI5@1236|Gammaproteobacteria,466ZV@72275|Alteromonadaceae 1236|Gammaproteobacteria K Belongs to the low molecular weight phosphotyrosine protein phosphatase family arsR GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0046685,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5,LMWPc k59_549773_1 330214.NIDE0426 5.78e-86 271.0 COG0539@1|root,COG1185@1|root,COG0539@2|Bacteria,COG1185@2|Bacteria,3J0CA@40117|Nitrospirae 40117|Nitrospirae J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_1594720_1 283166.BH14790 2.73e-29 110.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2U758@28211|Alphaproteobacteria,48TV0@772|Bartonellaceae 28211|Alphaproteobacteria M OmpA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_708911_1 1469613.JT55_07905 3.4e-12 67.8 COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2TUPH@28211|Alphaproteobacteria 28211|Alphaproteobacteria I enoyl-CoA hydratase isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_708911_2 487521.OCU_19640 2.85e-19 85.5 COG0778@1|root,COG0778@2|Bacteria,2I94X@201174|Actinobacteria,237EZ@1762|Mycobacteriaceae 201174|Actinobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_1385229_1 1177154.Y5S_01713 7.7e-35 137.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,1XI5R@135619|Oceanospirillales 135619|Oceanospirillales S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16 k59_342694_1 1173027.Mic7113_0671 3.21e-67 216.0 COG4360@1|root,COG4360@2|Bacteria,1G2S9@1117|Cyanobacteria,1H6XH@1150|Oscillatoriales 1117|Cyanobacteria F ATP adenylyltransferase apa2 - 2.7.7.53 ko:K00988 ko00230,map00230 - R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 - - - ATP_transf k59_1234773_1 331869.BAL199_24029 1.18e-40 148.0 COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2TSKH@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1651765_1 118173.KB235914_gene703 2.94e-75 251.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1G1HW@1117|Cyanobacteria,1H6Y0@1150|Oscillatoriales 1117|Cyanobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P k59_290508_1 983545.Glaag_3402 4.46e-44 147.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,1RNEV@1236|Gammaproteobacteria,464RY@72275|Alteromonadaceae 1236|Gammaproteobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_290508_2 999541.bgla_1g03190 4.3e-24 94.0 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2VSH0@28216|Betaproteobacteria,1K7WM@119060|Burkholderiaceae 28216|Betaproteobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_821120_1 330214.NIDE2545 1.13e-107 340.0 COG0458@1|root,COG0458@2|Bacteria,3J0BC@40117|Nitrospirae 40117|Nitrospirae F Carbamoyl-phosphate synthetase large chain, oligomerisation domain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_180366_2 1288494.EBAPG3_25020 0.000636 41.6 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria,372TR@32003|Nitrosomonadales 28216|Betaproteobacteria BQ PFAM histone deacetylase superfamily hda - - - - - - - - - - - Hist_deacetyl k59_967601_1 909663.KI867150_gene359 3.71e-72 241.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria,2MQBM@213462|Syntrophobacterales 28221|Deltaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_967601_2 880072.Desac_0849 7.01e-26 108.0 COG1847@1|root,COG1847@2|Bacteria,1RB1P@1224|Proteobacteria,42QPK@68525|delta/epsilon subdivisions,2WN58@28221|Deltaproteobacteria,2MRTE@213462|Syntrophobacterales 28221|Deltaproteobacteria S Jag_N - - - ko:K06346 - - - - ko00000 - - - Jag_N,KH_4,R3H k59_967601_4 997346.HMPREF9374_2544 5.25e-45 151.0 COG0590@1|root,COG0590@2|Bacteria,1V3HZ@1239|Firmicutes,4HH7S@91061|Bacilli,27BV3@186824|Thermoactinomycetaceae 91061|Bacilli FJ MafB19-like deaminase tadA GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam k59_1498576_1 945543.VIBR0546_17483 2.67e-35 134.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,1RQ8J@1236|Gammaproteobacteria,1XVFR@135623|Vibrionales 135623|Vibrionales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1234794_2 526225.Gobs_3547 5.4e-32 131.0 COG0596@1|root,COG0596@2|Bacteria,2IAVM@201174|Actinobacteria 201174|Actinobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 k59_236854_1 1192034.CAP_2858 7.97e-33 124.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42U04@68525|delta/epsilon subdivisions,2WQA9@28221|Deltaproteobacteria,2YV9U@29|Myxococcales 28221|Deltaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_290533_1 1276920.ADIAG_02582 8.72e-47 164.0 COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,1W7S7@1268|Micrococcaceae 201174|Actinobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - HHH_5,IMS,IMS_C,IMS_HHH k59_549819_1 414684.RC1_0140 4.64e-47 161.0 COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria,2JPGN@204441|Rhodospirillales 204441|Rhodospirillales S MazG nucleotide pyrophosphohydrolase domain mazG - 3.6.1.9 ko:K04765 ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100 - R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323 RC00002 ko00000,ko00001,ko01000 - - - MazG k59_181227_1 316067.Geob_3174 1.16e-65 214.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,42R3H@68525|delta/epsilon subdivisions,2WMNY@28221|Deltaproteobacteria,43T10@69541|Desulfuromonadales 28221|Deltaproteobacteria D NUBPL iron-transfer P-loop NTPase - - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,CbiA,HTH_25,ParA k59_181227_2 706587.Desti_0740 5.01e-79 248.0 COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,42MEY@68525|delta/epsilon subdivisions,2WM0F@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_1127549_2 1380391.JIAS01000017_gene544 1.26e-39 150.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2TTGI@28211|Alphaproteobacteria,2JQXB@204441|Rhodospirillales 204441|Rhodospirillales I Phosphate acyltransferases - - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_344129_1 1385520.N802_10035 8.06e-30 115.0 COG0406@1|root,COG0406@2|Bacteria,2GJYU@201174|Actinobacteria,4FH6Q@85021|Intrasporangiaceae 201174|Actinobacteria G Belongs to the phosphoglycerate mutase family gpmB GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237 3.1.3.85,5.4.2.11 ko:K01834,ko:K22306 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_1174462_1 1051501.AYTL01000028_gene2104 5.08e-35 129.0 COG4674@1|root,COG4674@2|Bacteria,1UIU8@1239|Firmicutes,4IT2P@91061|Bacilli,1ZS8G@1386|Bacillus 91061|Bacilli S ATPases associated with a variety of cellular activities - - - ko:K11962 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran,BCA_ABC_TP_C k59_968604_1 237609.PSAKL28_12740 1.67e-53 189.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - iSFV_1184.SFV_2673 ACT_4,HD_4,RelA_SpoT,TGS k59_1386182_1 436308.Nmar_1098 6.01e-160 455.0 COG0608@1|root,arCOG00424@2157|Archaea,41SE2@651137|Thaumarchaeota 651137|Thaumarchaeota L DHHA1 domain - - - ko:K07463 - - - - ko00000 - - - DHHA1 k59_506569_1 179408.Osc7112_2341 2.57e-18 84.0 COG3335@1|root,COG3335@2|Bacteria,1GQVS@1117|Cyanobacteria,1HC3Z@1150|Oscillatoriales 1117|Cyanobacteria L Rhodopirellula transposase family protein - - - - - - - - - - - - DDE_Tnp_ISAZ013 k59_506569_2 179408.Osc7112_1054 3.76e-44 157.0 COG3335@1|root,COG3335@2|Bacteria,1GQVS@1117|Cyanobacteria,1HC3Z@1150|Oscillatoriales 2|Bacteria L Rhodopirellula transposase family protein - - - - - - - - - - - - DDE_Tnp_ISAZ013 k59_1444747_2 1027273.GZ77_02190 9.97e-101 301.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,1XHYZ@135619|Oceanospirillales 135619|Oceanospirillales J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_181250_1 946483.Cenrod_0792 4.21e-17 84.3 COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,4AA5A@80864|Comamonadaceae 28216|Betaproteobacteria M Belongs to the peptidase S11 family pbpG - - ko:K07262 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S11 k59_90572_1 1282356.H045_01440 2.45e-43 157.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,1YMP1@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - iECO103_1326.ECO103_0087,iECO111_1330.ECO111_0088,iECW_1372.ECW_m0084,iEKO11_1354.EKO11_3829,iWFL_1372.ECW_m0084,ic_1306.c0103 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1540191_1 330214.NIDE1062 3.91e-44 150.0 COG1635@1|root,COG1635@2|Bacteria 2|Bacteria H Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur thi4 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0018131,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0046872,GO:0046914,GO:0052837,GO:0052838,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - ko:K03146 ko00730,ko01100,map00730,map01100 - R10685 RC00033,RC03253,RC03254 ko00000,ko00001 - - - FAD_oxidored,Thi4 k59_1540191_2 330214.NIDE1061 3.15e-95 279.0 COG3063@1|root,COG3063@2|Bacteria 2|Bacteria NU photosynthesis sscB - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_1081221_1 68194.JNXR01000003_gene3176 9e-94 290.0 COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria 201174|Actinobacteria Q pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Reductase_C k59_1178788_1 390989.JOEG01000009_gene1181 9.1e-37 127.0 COG0080@1|root,COG0080@2|Bacteria,2IFCK@201174|Actinobacteria,4DCKR@85008|Micromonosporales 201174|Actinobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_1178788_2 269799.Gmet_0616 9.16e-102 301.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,42MZP@68525|delta/epsilon subdivisions,2WJ1Z@28221|Deltaproteobacteria,43TYX@69541|Desulfuromonadales 28221|Deltaproteobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_1178788_3 768710.DesyoDRAFT_0258 6.28e-26 104.0 COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,261MK@186807|Peptococcaceae 186801|Clostridia J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_1178788_4 1238182.C882_2938 5.47e-38 131.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2U9FX@28211|Alphaproteobacteria,2JSU1@204441|Rhodospirillales 204441|Rhodospirillales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_400423_1 519989.ECTPHS_00275 5.78e-158 451.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,1RVJU@1236|Gammaproteobacteria,1WXJS@135613|Chromatiales 135613|Chromatiales I Poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009058,GO:0016234,GO:0042618,GO:0042619,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0070088,GO:0071704,GO:1901440,GO:1901441,GO:1901576 - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_924657_1 754476.Q7A_252 2.38e-43 156.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,460GP@72273|Thiotrichales 72273|Thiotrichales J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA - - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_297600_1 991905.SL003B_1039 5.47e-21 94.4 COG0625@1|root,COG0625@2|Bacteria,1R6UY@1224|Proteobacteria,2U1WS@28211|Alphaproteobacteria,4BSR9@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O Glutathione S-transferase, C-terminal domain - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_1448991_1 1449350.OCH239_04945 1.1e-64 212.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2TSZY@28211|Alphaproteobacteria,4KM4E@93682|Roseivivax 28211|Alphaproteobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_1540212_1 1038860.AXAP01000099_gene5310 4.57e-35 129.0 COG3474@1|root,COG3474@2|Bacteria,1R7NI@1224|Proteobacteria,2U1TH@28211|Alphaproteobacteria,3JVJQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C cytochrome - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_714805_1 1229909.NSED_04280 2.55e-40 134.0 arCOG07555@1|root,arCOG07555@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_714805_2 456442.Mboo_2282 4.47e-10 59.3 COG2340@1|root,COG3582@1|root,arCOG01769@2157|Archaea,arCOG03962@2157|Archaea,2Y7F2@28890|Euryarchaeota,2NBB2@224756|Methanomicrobia 224756|Methanomicrobia S AN1-like Zinc finger - - - - - - - - - - - - zf-AN1 k59_1390453_1 1121035.AUCH01000017_gene2293 1.34e-77 240.0 COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,2VH00@28216|Betaproteobacteria,2KUS0@206389|Rhodocyclales 206389|Rhodocyclales M UTP-glucose-1-phosphate uridylyltransferase epsT - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_714806_1 398767.Glov_0556 0.000583 41.2 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,42QTK@68525|delta/epsilon subdivisions,2WPG2@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_714806_2 671143.DAMO_1635 4.44e-19 87.8 COG0392@1|root,COG0392@2|Bacteria,2NPJC@2323|unclassified Bacteria 2|Bacteria S Lysylphosphatidylglycerol synthase TM region mprF - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_555644_1 1265505.ATUG01000002_gene2050 1.85e-08 60.5 COG3063@1|root,COG3063@2|Bacteria,1RK88@1224|Proteobacteria,42SIP@68525|delta/epsilon subdivisions,2WPT7@28221|Deltaproteobacteria,2MK0U@213118|Desulfobacterales 28221|Deltaproteobacteria NU Tetratricopeptide repeat tgl - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8 k59_297614_1 105559.Nwat_1184 9.14e-72 236.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WW1G@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_672034_1 1348114.OM33_19690 7.81e-13 73.9 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,2Q06Z@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF885 k59_1081256_1 446471.Xcel_2685 3.54e-08 61.6 COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4F3R5@85017|Promicromonosporaceae 201174|Actinobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_829190_1 710687.KI912270_gene6393 5.36e-06 52.4 COG2020@1|root,COG2020@2|Bacteria,2IIDW@201174|Actinobacteria,238RM@1762|Mycobacteriaceae 201174|Actinobacteria O Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - - - - - - - - - - PEMT k59_555654_1 1192124.LIG30_3274 4.38e-53 182.0 COG3119@1|root,COG3119@2|Bacteria 2|Bacteria P arylsulfatase activity - - 3.1.6.6 ko:K01133 - - - - ko00000,ko01000 - - - Glyco_tranf_2_3,Glycos_transf_2,Sulfatase k59_1506633_1 1042377.AFPJ01000023_gene664 5.09e-55 194.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,46DC5@72275|Alteromonadaceae 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_764310_1 251221.35213442 9.68e-41 146.0 COG1277@1|root,COG1277@2|Bacteria,1G09F@1117|Cyanobacteria 1117|Cyanobacteria S ABC-type transport system involved in multi-copper enzyme maturation, permease component - - - - - - - - - - - - ABC2_membrane_2 k59_1178829_1 644966.Tmar_1342 8.06e-17 79.3 COG0028@1|root,COG0028@2|Bacteria,1UYHG@1239|Firmicutes,24FP1@186801|Clostridia 186801|Clostridia EH Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1178829_2 637390.AFOH01000111_gene2829 3.41e-19 86.7 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,2NCAQ@225057|Acidithiobacillales 225057|Acidithiobacillales M Belongs to the ompA family - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_1241608_1 909943.HIMB100_00002850 1.5e-81 270.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria,4BPIN@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1506648_1 1343740.M271_48295 9.59e-16 83.2 COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria 201174|Actinobacteria P ATPase P-type (Transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_829217_1 768671.ThimaDRAFT_0605 7.8e-124 368.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WWEY@135613|Chromatiales 135613|Chromatiales C FAD linked oxidase - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1506650_1 84531.JMTZ01000013_gene2882 8.55e-20 94.0 COG0474@1|root,COG0474@2|Bacteria,1QWMC@1224|Proteobacteria,1T25Y@1236|Gammaproteobacteria,1XD5G@135614|Xanthomonadales 135614|Xanthomonadales P Domain of unknown function (DUF4153) - - - - - - - - - - - - DUF4153 k59_513252_1 330214.NIDE3786 1.68e-65 223.0 COG0474@1|root,COG0474@2|Bacteria,3J0WH@40117|Nitrospirae 40117|Nitrospirae P Cation transporter/ATPase, N-terminus - - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_1178836_1 402626.Rpic_2102 9.95e-39 141.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria,1K289@119060|Burkholderiaceae 28216|Betaproteobacteria C Catalyzes the reversible hydration of fumarate to (S)- malate fumA - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_1178836_2 913865.DOT_0224 2.05e-77 240.0 COG3332@1|root,COG3332@2|Bacteria,1UYHE@1239|Firmicutes,24I1W@186801|Clostridia,264ZH@186807|Peptococcaceae 186801|Clostridia S Transport and Golgi organisation 2 - - - - - - - - - - - - TANGO2 k59_297646_1 323850.Shew_3123 2.55e-40 152.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,2QB36@267890|Shewanellaceae 1236|Gammaproteobacteria M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) mrcB GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008289,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042277,GO:0042546,GO:0042597,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071723,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iECIAI39_1322.ECIAI39_0153,iSBO_1134.SBO_0138,iSbBS512_1146.SbBS512_E0140,iYL1228.KPN_00164 PBP1_TM,Transgly,Transpeptidase,UB2H k59_924715_1 1051632.TPY_3150 1.61e-54 188.0 COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia 186801|Clostridia L PFAM transposase, mutator - - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_1133321_1 1415780.JPOG01000001_gene2645 9.72e-20 92.4 COG0457@1|root,COG0457@2|Bacteria,1MVH9@1224|Proteobacteria,1RQ3R@1236|Gammaproteobacteria,1X3F2@135614|Xanthomonadales 135614|Xanthomonadales S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 k59_1133321_2 365528.KB891148_gene4901 1.66e-67 215.0 COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria,4EU6Q@85013|Frankiales 201174|Actinobacteria I Thiolase, C-terminal domain - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_869438_1 525146.Ddes_1456 4.38e-77 242.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2WIQN@28221|Deltaproteobacteria,2M85T@213115|Desulfovibrionales 28221|Deltaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_608589_1 1128912.GMES_0843 4.75e-35 128.0 COG0810@1|root,COG0810@2|Bacteria,1PEDH@1224|Proteobacteria,1RRNT@1236|Gammaproteobacteria,464BN@72275|Alteromonadaceae 1236|Gammaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_974696_1 344747.PM8797T_13620 2.05e-27 108.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_870762_2 765914.ThisiDRAFT_1072 2.06e-37 132.0 COG0852@1|root,COG0852@2|Bacteria,1NVVE@1224|Proteobacteria 1224|Proteobacteria C Respiratory-chain NADH dehydrogenase, 30 Kd subunit - - - - - - - - - - - - Complex1_30kDa k59_870762_3 525373.HMPREF0766_11876 1.1e-14 75.9 COG1143@1|root,COG1143@2|Bacteria,4NI9I@976|Bacteroidetes,1IS7C@117747|Sphingobacteriia 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_870762_4 1121918.ARWE01000001_gene638 2.36e-33 124.0 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,42RIC@68525|delta/epsilon subdivisions,2WPRF@28221|Deltaproteobacteria,43UU6@69541|Desulfuromonadales 28221|Deltaproteobacteria H Biotin/lipoate A/B protein ligase family lipB - 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB,NUDIX k59_974698_1 1190603.AJYD01000095_gene3618 1.88e-24 105.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XSK2@135623|Vibrionales 135623|Vibrionales M Belongs to the peptidase S1C family degQ - 3.4.21.107 ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_299028_1 391165.GbCGDNIH1_0054 5.42e-32 129.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2TR6F@28211|Alphaproteobacteria,2JR6A@204441|Rhodospirillales 204441|Rhodospirillales C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_608592_2 1229909.NSED_04335 4.77e-47 163.0 COG0034@1|root,arCOG00093@2157|Archaea,41S7N@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,Pribosyltran k59_244107_1 244582.JQAK01000009_gene598 3.55e-53 179.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1601068_1 111780.Sta7437_0039 5.85e-52 183.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1GQQT@1117|Cyanobacteria,3VNND@52604|Pleurocapsales 1117|Cyanobacteria T diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF k59_1601068_2 1042377.AFPJ01000005_gene2448 3.31e-12 67.8 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RNVM@1236|Gammaproteobacteria,465B3@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the pirin family XCC2717 - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_143635_1 1380394.JADL01000008_gene3764 2.38e-35 132.0 28PTM@1|root,2ZCEU@2|Bacteria,1R5DD@1224|Proteobacteria,2TVG7@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Family of unknown function (DUF5309) - - - - - - - - - - - - DUF5309 k59_401601_1 1510531.JQJJ01000008_gene3538 5.7e-18 94.7 COG4485@1|root,COG4485@2|Bacteria,1NBM0@1224|Proteobacteria,2U1FH@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Bacterial membrane protein, YfhO - - - - - - - - - - - - - k59_557067_1 1122929.KB908221_gene2842 1.41e-24 107.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system large permease component - - - - - - - - - - - - DctM k59_351177_1 313628.LNTAR_25145 3.34e-20 86.3 COG3119@1|root,COG3119@2|Bacteria 2|Bacteria P arylsulfatase activity - - - - - - - - - - - - Sulfatase k59_831132_1 1121918.ARWE01000001_gene1806 5.15e-08 58.2 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42NNX@68525|delta/epsilon subdivisions,2WJ9P@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Secretion ATPase, PEP-CTERM locus subfamily - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22 k59_870775_1 1254432.SCE1572_39505 8.63e-39 141.0 2C7Q9@1|root,2Z96K@2|Bacteria,1MWKA@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1179966_1 471223.GWCH70_1142 1.66e-54 184.0 COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,4HBDV@91061|Bacilli,1WFZI@129337|Geobacillus 91061|Bacilli J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_299040_1 323261.Noc_0672 1.25e-93 286.0 COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,1RZGN@1236|Gammaproteobacteria,1X1HI@135613|Chromatiales 135613|Chromatiales L Transposase domain (DUF772) - - - ko:K07481 - - - - ko00000 - - - DUF772 k59_401603_1 986075.CathTA2_1846 1.62e-61 198.0 COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,4HAKF@91061|Bacilli 91061|Bacilli P phosphate transport system permease pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_401603_2 1146883.BLASA_4535 1.3e-92 281.0 COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4ERC8@85013|Frankiales 201174|Actinobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_974717_1 215803.DB30_6914 1.01e-54 179.0 COG4221@1|root,COG4221@2|Bacteria,1PWXN@1224|Proteobacteria,43811@68525|delta/epsilon subdivisions,2X3B3@28221|Deltaproteobacteria,2YV70@29|Myxococcales 28221|Deltaproteobacteria S Domain of unknown function (DUF4336) - - - - - - - - - - - - DUF4336 k59_1661859_1 349124.Hhal_0856 6.97e-25 96.7 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,1S8VX@1236|Gammaproteobacteria,1WYZN@135613|Chromatiales 135613|Chromatiales J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_1661859_2 1089439.KB902243_gene1279 3.7e-15 73.6 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,460DP@72273|Thiotrichales 72273|Thiotrichales J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_674017_1 251221.35210568 2.75e-100 300.0 COG0226@1|root,COG0226@2|Bacteria,1FZZ0@1117|Cyanobacteria 1117|Cyanobacteria P TIGRFAM phosphate binding protein sphX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like,PBP_like_2 k59_1336206_1 1463825.JNXC01000012_gene1934 1.08e-18 85.9 COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4E4Z6@85010|Pseudonocardiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1336206_2 397278.JOJN01000007_gene3148 1.83e-07 52.8 COG1028@1|root,COG1028@2|Bacteria,2GIX2@201174|Actinobacteria,4DNUV@85009|Propionibacteriales 201174|Actinobacteria IQ reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_974725_1 1128421.JAGA01000002_gene119 8.14e-47 165.0 COG0334@1|root,COG0334@2|Bacteria,2NNRJ@2323|unclassified Bacteria 2|Bacteria E Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_870792_1 118168.MC7420_2475 3.11e-75 253.0 COG0474@1|root,COG0474@2|Bacteria,1G4BB@1117|Cyanobacteria,1H7WQ@1150|Oscillatoriales 1117|Cyanobacteria P Cation transporter/ATPase, N-terminus - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_1661880_1 582515.KR51_00017370 2.72e-22 92.8 COG3695@1|root,COG3695@2|Bacteria,1G82G@1117|Cyanobacteria 1117|Cyanobacteria L Methylated dna-protein cysteine methyltransferase - - - ko:K07443 - - - - ko00000 - - - DNA_binding_1 k59_1301011_1 1205680.CAKO01000002_gene2187 2.61e-44 153.0 COG0778@1|root,COG0778@2|Bacteria,1NIJ8@1224|Proteobacteria,2TUQN@28211|Alphaproteobacteria,2JWUG@204441|Rhodospirillales 204441|Rhodospirillales C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_1301011_2 243231.GSU1168 2.82e-39 141.0 COG2340@1|root,COG2340@2|Bacteria,1N566@1224|Proteobacteria,42UZI@68525|delta/epsilon subdivisions,2WR1P@28221|Deltaproteobacteria,43UVM@69541|Desulfuromonadales 28221|Deltaproteobacteria S Cysteine-rich secretory protein family - - - - - - - - - - - - CAP k59_186551_1 247633.GP2143_03333 8.92e-83 259.0 COG2334@1|root,COG2334@2|Bacteria,1PGM7@1224|Proteobacteria,1RNPA@1236|Gammaproteobacteria,1JADP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S homoserine kinase type II (protein kinase fold) - - - - - - - - - - - - APH k59_186551_2 501479.ACNW01000047_gene428 1.37e-08 59.7 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TR8R@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family tpa - 2.6.1.77 ko:K03851 ko00430,ko01100,map00430,map01100 - R05652 RC00008,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_186558_1 32057.KB217478_gene134 6.64e-59 198.0 COG1834@1|root,COG1834@2|Bacteria,1G48J@1117|Cyanobacteria,1HN0E@1161|Nostocales 1117|Cyanobacteria E amidinotransferase - - 2.1.4.1 ko:K00613 ko00260,ko00330,ko01100,map00260,map00330,map01100 M00047 R00565,R01989 RC00024,RC02749 ko00000,ko00001,ko00002,ko01000 - - - - k59_186558_2 1396.DJ87_5639 2.97e-08 57.4 COG0451@1|root,COG0451@2|Bacteria,1TS59@1239|Firmicutes,4HAY0@91061|Bacilli,1ZF5A@1386|Bacillus 91061|Bacilli M GDP-mannose 4,6 dehydratase arnA - 4.2.1.46,5.1.3.2 ko:K01710,ko:K01784 ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00362,M00632,M00793 R00291,R02984,R06513 RC00289,RC00402 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_716249_1 1502852.FG94_05140 5.21e-43 153.0 COG2391@1|root,COG2391@2|Bacteria,1PF9B@1224|Proteobacteria,2VKKD@28216|Betaproteobacteria 28216|Betaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_1249693_1 870187.Thini_4223 1.33e-12 69.3 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,4601J@72273|Thiotrichales 72273|Thiotrichales E Sodium:alanine symporter family - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_1249693_2 644282.Deba_2756 3.11e-18 84.7 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria 28221|Deltaproteobacteria C CoA-binding domain protein - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_1342981_1 470704.XP_007761371.1 3.31e-46 158.0 COG1028@1|root,KOG0725@2759|Eukaryota,395BZ@33154|Opisthokonta 33154|Opisthokonta Q testosterone 17-beta-dehydrogenase (NADP+) activity - - - - - - - - - - - - adh_short_C2 k59_150545_1 1038860.AXAP01000023_gene7347 1.5e-121 358.0 COG0596@1|root,COG0596@2|Bacteria,1MWVN@1224|Proteobacteria,2TQVB@28211|Alphaproteobacteria,3JRID@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Epoxide hydrolase N terminus MA20_04980 - - ko:K21159 ko01059,map01059 - - - ko00000,ko00001 - - - EHN k59_194659_1 439235.Dalk_3185 5.36e-45 159.0 COG0204@1|root,COG0204@2|Bacteria,1RF5A@1224|Proteobacteria,4300N@68525|delta/epsilon subdivisions,2WVIK@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase k59_1143034_1 1288494.EBAPG3_13140 2.13e-112 332.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,372I8@32003|Nitrosomonadales 28216|Betaproteobacteria E Belongs to the Orn Lys Arg decarboxylase class-II family - - 4.1.1.17 ko:K01581 ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130 M00134 R00670 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1034514_2 457570.Nther_0320 3.83e-13 64.7 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,24QJE@186801|Clostridia 186801|Clostridia K Cold shock protein - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_306899_1 1353531.AZNX01000001_gene1869 2.01e-24 108.0 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,2TUBP@28211|Alphaproteobacteria,4B77J@82115|Rhizobiaceae 28211|Alphaproteobacteria S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_409831_1 237368.SCABRO_00481 1.1e-20 89.4 COG3769@1|root,COG3769@2|Bacteria,2J39C@203682|Planctomycetes 203682|Planctomycetes S haloacid dehalogenase-like hydrolase - - - - - - - - - - - - Hydrolase_3 k59_194692_1 330214.NIDE4155 5.99e-105 315.0 293H1@1|root,2ZQZ6@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_464378_1 765910.MARPU_00500 4.82e-94 289.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales 135613|Chromatiales E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_20222_1 713587.THITH_04970 7.96e-09 62.0 COG1538@1|root,COG1538@2|Bacteria,1R705@1224|Proteobacteria,1S0X1@1236|Gammaproteobacteria 1236|Gammaproteobacteria MU PFAM Outer membrane efflux protein - - - - - - - - - - - - OEP k59_358877_1 1056820.KB900674_gene2509 1.26e-57 197.0 COG3519@1|root,COG3519@2|Bacteria,1MUY4@1224|Proteobacteria,1RPK4@1236|Gammaproteobacteria,2PPQX@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Pfam:T6SS_VipB vasA - - ko:K11896 - M00334 - - ko00000,ko00002,ko02044 3.A.23.1 - - T6SS_TssF k59_1143086_1 472759.Nhal_3162 5.61e-90 278.0 COG3829@1|root,COG3829@2|Bacteria,1MXSB@1224|Proteobacteria,1RVV6@1236|Gammaproteobacteria,1WWEN@135613|Chromatiales 135613|Chromatiales K Sigma-54 interaction domain - - - - - - - - - - - - Sigma54_activat k59_934057_1 926550.CLDAP_16150 1.6e-77 246.0 COG2128@1|root,COG2128@2|Bacteria 2|Bacteria S hydroperoxide reductase activity - - - - - - - - - - - - CMD,DUF3179 k59_1398499_1 314282.PCNPT3_03875 2.2e-51 189.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,2QH74@267894|Psychromonadaceae 1236|Gammaproteobacteria M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0009636,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042221,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0050896,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:1901264 - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - iG2583_1286.G2583_0058 OstA,OstA_C k59_1549498_1 443143.GM18_0693 7.3e-21 97.8 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,42NYD@68525|delta/epsilon subdivisions,2WKHT@28221|Deltaproteobacteria,43T2W@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM permease YjgP YjgQ family protein lptF - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1034566_1 1116472.MGMO_86c00050 1.31e-49 172.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1XDU7@135618|Methylococcales 135618|Methylococcales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_1090597_1 1266925.JHVX01000003_gene443 6.99e-62 203.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,3723N@32003|Nitrosomonadales 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1034573_1 56780.SYN_00890 4.02e-30 119.0 COG0317@1|root,COG0460@1|root,COG0317@2|Bacteria,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,42MGS@68525|delta/epsilon subdivisions,2WJ1K@28221|Deltaproteobacteria,2MQ61@213462|Syntrophobacterales 28221|Deltaproteobacteria E PFAM Homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_1034573_2 671143.DAMO_0588 1.3e-12 67.0 COG0498@1|root,COG0498@2|Bacteria,2NP4T@2323|unclassified Bacteria 2|Bacteria E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine thrC GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM0546,iSB619.SA_RS06615,iYO844.BSU32250 PALP k59_564572_2 1333998.M2A_0667 5.65e-95 288.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria,4BP5Q@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Thiolase, C-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_878168_2 869724.H6BI62_9CAUD 4.24e-63 194.0 4QDIK@10239|Viruses,4QUY8@35237|dsDNA viruses no RNA stage,4QSBW@28883|Caudovirales,4QI4K@10662|Myoviridae 10662|Myoviridae S copper ion binding - - - - - - - - - - - - - k59_1249798_2 351746.Pput_4874 2.71e-73 226.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1YXAD@136845|Pseudomonas putida group 1236|Gammaproteobacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_1186867_1 436308.Nmar_1507 1.28e-28 105.0 arCOG10587@1|root,arCOG10587@2157|Archaea,41SVM@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1188298_1 1123519.PSJM300_16135 9.72e-19 82.4 COG1017@1|root,COG1017@2|Bacteria,1RI9P@1224|Proteobacteria,1S7H7@1236|Gammaproteobacteria,1Z2TQ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C nitric oxide dioxygenase activity - - - - - - - - - - - - - k59_982072_1 105559.Nwat_2753 3.04e-19 90.5 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria,1WX4U@135613|Chromatiales 135613|Chromatiales T PFAM Metal-dependent phosphohydrolase, HD - - - - - - - - - - - - DUF3391,HD_5 k59_773968_1 1288826.MSNKSG1_12967 1.95e-40 141.0 COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria 1224|Proteobacteria S ybak prolyl-trna synthetase associated - - - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_1458543_2 1366050.N234_02305 5.28e-43 152.0 COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,2VHXK@28216|Betaproteobacteria,1K5W8@119060|Burkholderiaceae 28216|Betaproteobacteria C hydroxypyruvate reductase ttuD2 - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_982075_1 28229.ND2E_1736 4.75e-19 84.7 COG3339@1|root,COG3339@2|Bacteria,1RAN7@1224|Proteobacteria,1S291@1236|Gammaproteobacteria,2Q6RN@267889|Colwelliaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF1232) - - - - - - - - - - - - DUF1232 k59_982075_2 402777.KB235903_gene1866 1.48e-26 114.0 COG0642@1|root,COG0745@1|root,COG2114@1|root,COG3437@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,1G0F6@1117|Cyanobacteria,1H7AR@1150|Oscillatoriales 1117|Cyanobacteria T PFAM Adenylate and Guanylate cyclase catalytic domain cyaC - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - GAF,Guanylate_cyc,HATPase_c,HisKA,Response_reg k59_618416_1 1333998.M2A_0667 1.5e-37 135.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria,4BP5Q@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Thiolase, C-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_618416_2 1333998.M2A_0668 3.02e-34 120.0 COG1545@1|root,COG1545@2|Bacteria,1RFF1@1224|Proteobacteria,2UTI3@28211|Alphaproteobacteria 28211|Alphaproteobacteria S DUF35 OB-fold domain, acyl-CoA-associated - - - - - - - - - - - - DUF35_N,OB_aCoA_assoc k59_1344570_1 117187.FVEG_03566T0 0.000101 45.4 2CXMB@1|root,2RYDN@2759|Eukaryota,3A17Z@33154|Opisthokonta,3P1SX@4751|Fungi,3QVYV@4890|Ascomycota,21AE4@147550|Sordariomycetes,3TIYQ@5125|Hypocreales,1FNDY@110618|Nectriaceae 4751|Fungi S Conserved hypothetical protein - - - - - - - - - - - - - k59_360271_1 1957.JODX01000018_gene1588 9.73e-07 53.5 COG1335@1|root,COG1335@2|Bacteria 2|Bacteria Q hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - - - - - - - - - - - - Isochorismatase k59_618442_1 298655.KI912266_gene4915 8.37e-74 231.0 COG4221@1|root,COG4221@2|Bacteria,2IGP3@201174|Actinobacteria 201174|Actinobacteria S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_252879_1 1046724.KB889923_gene1408 1.03e-28 115.0 COG2960@1|root,COG2960@2|Bacteria,1NJYD@1224|Proteobacteria,1RYI7@1236|Gammaproteobacteria,46850@72275|Alteromonadaceae 1236|Gammaproteobacteria M long-chain fatty acid transporting porin activity - - - - - - - - - - - - Porin_O_P k59_1344588_1 228410.NE1047 3.36e-20 86.7 COG2142@1|root,COG2142@2|Bacteria,1MZR9@1224|Proteobacteria,2VSJN@28216|Betaproteobacteria,373DV@32003|Nitrosomonadales 28216|Betaproteobacteria C Succinate dehydrogenase/Fumarate reductase transmembrane subunit sdhD - - ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_1344588_2 472759.Nhal_0708 3.69e-50 173.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales 135613|Chromatiales C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1400036_1 370438.PTH_0203 1.2e-39 145.0 COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,248BE@186801|Clostridia,260AI@186807|Peptococcaceae 186801|Clostridia H dihydropteroate synthase folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS03115 Pterin_bind k59_879400_1 105559.Nwat_3050 3.18e-133 404.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1WXCY@135613|Chromatiales 135613|Chromatiales G phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1551028_1 105559.Nwat_0033 2.55e-33 127.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1WXMZ@135613|Chromatiales 135613|Chromatiales I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_1551028_2 105559.Nwat_0032 3.49e-47 158.0 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1WY33@135613|Chromatiales 135613|Chromatiales U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB - - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_465916_1 391626.OAN307_c30700 8.59e-40 144.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TTAW@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - Transposase_mut k59_411465_1 717231.Flexsi_0969 1.22e-209 597.0 COG0465@1|root,COG0465@2|Bacteria,2GF02@200930|Deferribacteres 200930|Deferribacteres O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_1144981_1 713587.THITH_12015 2.83e-87 271.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria,1WXQI@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_8 k59_1251623_1 373903.Hore_01680 7.08e-58 194.0 COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,3WADU@53433|Halanaerobiales 186801|Clostridia M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_1188368_1 444860.E3SIP9_9CAUD 2.36e-15 72.0 4QAMK@10239|Viruses,4QX4A@35237|dsDNA viruses no RNA stage,4QQJK@28883|Caudovirales,4QIC8@10662|Myoviridae 10662|Myoviridae S Domain of unknown function (DUF1825) - - - - - - - - - - - - - k59_1188368_2 444859.E3SI15_9CAUD 4.84e-30 115.0 4QAJD@10239|Viruses,4QW4M@35237|dsDNA viruses no RNA stage,4QQ7U@28883|Caudovirales,4QIAP@10662|Myoviridae 10662|Myoviridae S gp32 DNA binding protein like - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_1188370_1 864069.MicloDRAFT_00001170 6.66e-58 201.0 COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria,1JT7R@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_1551050_1 6412.HelroP103347 8.94e-204 579.0 COG1838@1|root,2QT04@2759|Eukaryota,39WD1@33154|Opisthokonta,3BI53@33208|Metazoa,3D3TJ@33213|Bilateria 33208|Metazoa C Fumarase C-terminus - - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_152513_1 1267535.KB906767_gene823 6.15e-48 173.0 COG1198@1|root,COG1198@2|Bacteria,3Y2NY@57723|Acidobacteria,2JI1K@204432|Acidobacteriia 204432|Acidobacteriia L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_618507_1 876269.ARWA01000001_gene293 2.03e-45 166.0 COG1252@1|root,COG2259@1|root,COG1252@2|Bacteria,COG2259@2|Bacteria,1MX96@1224|Proteobacteria,2TQT2@28211|Alphaproteobacteria,3NBSI@45404|Beijerinckiaceae 28211|Alphaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase ndh - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_935585_1 1123033.ARNF01000089_gene1140 7.08e-34 121.0 COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,1S3XB@1236|Gammaproteobacteria,3NJ77@468|Moraxellaceae 1236|Gammaproteobacteria F Nudix N-terminal - - - - - - - - - - - - NUDIX,Nudix_N_2 k59_20908_1 278963.ATWD01000001_gene3621 4.49e-20 91.3 COG1216@1|root,COG1216@2|Bacteria,3Y59U@57723|Acidobacteria,2JJU8@204432|Acidobacteriia 204432|Acidobacteriia S PFAM Glycosyl transferase family 2 - - - ko:K07011 - - - - ko00000 - - - Glycos_transf_2 k59_1251671_1 762903.Pedsa_2767 4.97e-90 273.0 COG0861@1|root,COG0861@2|Bacteria,4NFFD@976|Bacteroidetes,1IQQC@117747|Sphingobacteriia 976|Bacteroidetes P Membrane protein TerC, possibly involved in tellurium resistance - - - - - - - - - - - - TerC k59_1035868_1 1123504.JQKD01000003_gene442 4.01e-56 192.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2VIY8@28216|Betaproteobacteria,4AHFM@80864|Comamonadaceae 28216|Betaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_879439_1 1347369.CCAD010000087_gene1866 5.12e-96 293.0 COG0656@1|root,COG0656@2|Bacteria,1TSG5@1239|Firmicutes,4HAMT@91061|Bacilli,1ZEPD@1386|Bacillus 91061|Bacilli S Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_411511_1 765913.ThidrDRAFT_1717 5.97e-65 207.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1WX6F@135613|Chromatiales 135613|Chromatiales I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_411511_2 1283300.ATXB01000001_gene594 1.7e-11 65.5 COG3017@1|root,COG3017@2|Bacteria,1QJPB@1224|Proteobacteria,1THQ9@1236|Gammaproteobacteria,1XFAB@135618|Methylococcales 135618|Methylococcales M Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein - - - ko:K02494 - - - - ko00000 - - - LolB k59_1344648_1 269800.Tfu_0198 1.07e-16 79.3 COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria,4EHSG@85012|Streptosporangiales 201174|Actinobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679 - ko:K03686,ko:K05516 - - - - ko00000,ko03029,ko03036,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1344648_2 1123274.KB899431_gene3267 6.58e-14 72.8 COG0576@1|root,COG0576@2|Bacteria,2J7UP@203691|Spirochaetes 203691|Spirochaetes O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_1035873_1 1196083.SALWKB12_0299 8.24e-44 155.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria,2KQEA@206351|Neisseriales 206351|Neisseriales Q Psort location CytoplasmicMembrane, score 10.00 - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_1092109_1 1123376.AUIU01000015_gene435 1.27e-54 185.0 COG0460@1|root,COG0460@2|Bacteria,3J0G1@40117|Nitrospirae 40117|Nitrospirae E Homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_982199_2 1279019.ARQK01000047_gene1021 2.8e-16 75.9 2EFAS@1|root,3393N@2|Bacteria,1NDQN@1224|Proteobacteria,1SSBD@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_360355_1 519989.ECTPHS_03392 4.16e-94 283.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,1WWXT@135613|Chromatiales 135613|Chromatiales V PFAM ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_360356_1 398512.JQKC01000005_gene5336 1.63e-13 75.1 COG1277@1|root,COG1277@2|Bacteria,1UZXS@1239|Firmicutes,248ME@186801|Clostridia,3WRFQ@541000|Ruminococcaceae 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC2_membrane_2,ABC2_membrane_3,ABC2_membrane_5 k59_196535_1 1469245.JFBG01000038_gene1801 4.85e-12 71.2 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1X0Z1@135613|Chromatiales 135613|Chromatiales P Sulfatase - - - - - - - - - - - - Sulfatase k59_784384_1 371042.NG99_00095 3.69e-42 155.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,3X4EW@551|Erwinia 1236|Gammaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035,ko:K13889 ko02010,ko02024,map02010,map02024 M00239,M00348 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.11 - - SBP_bac_5 k59_679949_1 1504672.669784377 2.07e-26 100.0 COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,2VTC8@28216|Betaproteobacteria,4AIEB@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_575336_1 487521.OCU_19160 4.33e-79 250.0 COG1960@1|root,COG1960@2|Bacteria,2GITF@201174|Actinobacteria,236CQ@1762|Mycobacteriaceae 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_575336_2 1041522.MCOL_V217038 3.64e-14 69.3 COG2030@1|root,COG2030@2|Bacteria,2IHT0@201174|Actinobacteria,2392X@1762|Mycobacteriaceae 201174|Actinobacteria I MaoC like domain - - - - - - - - - - - - MaoC_dehydratas k59_209578_1 180281.CPCC7001_2411 8.32e-19 84.3 COG2801@1|root,COG3666@1|root,COG2801@2|Bacteria,COG3666@2|Bacteria,1GMTA@1117|Cyanobacteria,22TVU@167375|Cyanobium 1117|Cyanobacteria L Integrase core domain - - - - - - - - - - - - - k59_1515299_1 391038.Bphy_4588 2.34e-05 46.2 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VSSJ@28216|Betaproteobacteria,1K5FA@119060|Burkholderiaceae 28216|Betaproteobacteria T PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - AAA_16,BTAD,Guanylate_cyc,SAM_1,TPR_12,TPR_8,Trans_reg_C k59_1515299_2 1266909.AUAG01000010_gene2615 1.27e-24 96.7 COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,1S5ZA@1236|Gammaproteobacteria,1WYFA@135613|Chromatiales 135613|Chromatiales P part of a sulfur-relay system - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_418550_1 56780.SYN_00038 7.88e-47 162.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,2MQSW@213462|Syntrophobacterales 28221|Deltaproteobacteria F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_1620874_2 13690.CP98_01595 3.91e-16 80.1 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2TU0G@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_314962_1 1449065.JMLL01000010_gene1364 3.02e-08 56.2 COG3735@1|root,COG3735@2|Bacteria,1R7DV@1224|Proteobacteria,2U24S@28211|Alphaproteobacteria,43RQ7@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S TraB family - - - ko:K09973 - - - - ko00000 - - - TraB k59_314962_2 330214.NIDE0473 1.42e-115 346.0 COG4307@1|root,COG4307@2|Bacteria 2|Bacteria T Protein conserved in bacteria - - - - - - - - - - - - Peptidase_Mx,zinc-ribbon_6 k59_314962_3 330214.NIDE0474 2.16e-37 136.0 COG1181@1|root,COG1181@2|Bacteria 2|Bacteria F Belongs to the D-alanine--D-alanine ligase family ddlB1 - 6.3.2.4,6.3.5.5 ko:K01921,ko:K01955 ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502 M00051 R00256,R00575,R01150,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000,ko01011 - - - Dala_Dala_lig_C k59_732891_2 1417296.U879_18725 0.000107 49.7 COG3012@1|root,COG3012@2|Bacteria,1NV40@1224|Proteobacteria,2U21K@28211|Alphaproteobacteria 28211|Alphaproteobacteria S SEC-C Motif Domain Protein - - - - - - - - - - - - - k59_471350_1 1449049.JONW01000005_gene1464 5.87e-74 233.0 COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2U36X@28211|Alphaproteobacteria,2KI9G@204458|Caulobacterales 204458|Caulobacterales S Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_105692_1 985867.AEWF01000001_gene2152 1.59e-16 80.5 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TRAH@28211|Alphaproteobacteria,47EVE@766|Rickettsiales 766|Rickettsiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_105692_2 269800.Tfu_2691 1.04e-31 120.0 COG1905@1|root,COG1905@2|Bacteria,2GKG0@201174|Actinobacteria,4EHWV@85012|Streptosporangiales 201174|Actinobacteria C Thioredoxin-like [2Fe-2S] ferredoxin nuoE GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_105692_3 1131269.AQVV01000018_gene1933 4.62e-39 134.0 COG0838@1|root,COG0838@2|Bacteria 2|Bacteria C NADH dehydrogenase (ubiquinone) activity nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_367294_1 268746.Q58M37_BPPRM 1.07e-48 163.0 4QD3S@10239|Viruses,4QS0E@28883|Caudovirales,4QK4Z@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_367294_2 444860.E3SJE6_9CAUD 3.29e-31 110.0 4QCB4@10239|Viruses,4QVPP@35237|dsDNA viruses no RNA stage,4QQW0@28883|Caudovirales,4QI3R@10662|Myoviridae 10662|Myoviridae S Protein of unknown function (DUF2973) - - - - - - - - - - - - - k59_367294_3 1589733.A0A0C5AMY6_9CAUD 1.8e-24 95.5 4QEG5@10239|Viruses,4QSW3@28883|Caudovirales,4QJ1G@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_314967_1 395493.BegalDRAFT_0253 1.17e-46 166.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,4607S@72273|Thiotrichales 72273|Thiotrichales T nitrogen regulation protein NR(I) - - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_837324_1 999547.KI421502_gene3965 2.54e-16 79.3 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2TS04@28211|Alphaproteobacteria,2824B@191028|Leisingera 28211|Alphaproteobacteria E Histidinol dehydrogenase hisD_3 - 1.1.1.308 ko:K15509 - - - - ko00000,ko01000 - - - Histidinol_dh k59_837324_2 1096769.Pelub83DRAFT_0294 2.32e-231 647.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,4BRA7@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q TIGRFAM TRAP transporter, DctM subunit - - - - - - - - - - - - DctM,DctQ k59_837324_3 1096769.Pelub83DRAFT_0295 2.8e-82 249.0 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2UD1C@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_837324_4 1469245.JFBG01000031_gene1368 4.89e-122 357.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1WW0A@135613|Chromatiales 135613|Chromatiales Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_680918_1 436308.Nmar_0078 9.17e-96 282.0 COG2109@1|root,arCOG04678@2157|Archaea,41SFP@651137|Thaumarchaeota 651137|Thaumarchaeota H ATP corrinoid adenosyltransferase - - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - CobA_CobO_BtuR k59_1307173_1 1121940.AUDZ01000007_gene2238 3.6e-16 79.3 COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,1T1NH@1236|Gammaproteobacteria,1XISA@135619|Oceanospirillales 135619|Oceanospirillales EGP Acetyl-coenzyme A transporter 1 - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - Acatn,MFS_1 k59_1307173_2 1163617.SCD_n00068 1.17e-11 63.2 COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,2VWDY@28216|Betaproteobacteria 28216|Betaproteobacteria S Belongs to the UPF0235 family - - - ko:K09131 - - - - ko00000 - - - DUF167 k59_54153_1 1380394.JADL01000011_gene3984 1.06e-16 73.9 COG1975@1|root,COG1975@2|Bacteria,1RI4U@1224|Proteobacteria,2U9FQ@28211|Alphaproteobacteria,2JTGI@204441|Rhodospirillales 204441|Rhodospirillales O XdhC and CoxI family - - - - - - - - - - - - XdhC_CoxI k59_54153_2 1089551.KE386572_gene4458 1.09e-37 134.0 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2TUF3@28211|Alphaproteobacteria,4BQEV@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O XdhC Rossmann domain MA20_09415 - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_575993_1 1116472.MGMO_25c00370 3.36e-39 137.0 COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,1S41X@1236|Gammaproteobacteria,1XEGP@135618|Methylococcales 135618|Methylococcales NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis - - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD k59_105719_1 1121033.AUCF01000011_gene1777 1.91e-32 119.0 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2TUND@28211|Alphaproteobacteria,2JSMN@204441|Rhodospirillales 204441|Rhodospirillales T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_105719_2 1380355.JNIJ01000030_gene5643 1.2e-19 89.7 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQX3@28211|Alphaproteobacteria,3JR5W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_9,Pkinase k59_628769_1 56780.SYN_02767 1.92e-78 243.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,42MI2@68525|delta/epsilon subdivisions,2WJ5W@28221|Deltaproteobacteria,2MR0A@213462|Syntrophobacterales 28221|Deltaproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2848 Pribosyl_synth,Pribosyltran_N k59_628769_2 1246459.KB898356_gene2267 4.56e-07 54.7 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2TUFV@28211|Alphaproteobacteria,4B71X@82115|Rhizobiaceae 28211|Alphaproteobacteria I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_523922_1 1379698.RBG1_1C00001G1725 3.37e-99 325.0 COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria 2|Bacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrD - - ko:K03296,ko:K18138,ko:K18307 ko01501,ko01503,ko02024,map01501,map01503,map02024 M00644,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.20,2.A.6.2.32 - - ACR_tran k59_523922_2 323850.Shew_3001 3.95e-29 118.0 COG0834@1|root,COG1301@1|root,COG0834@2|Bacteria,COG1301@2|Bacteria,1P22C@1224|Proteobacteria,1RSGY@1236|Gammaproteobacteria,2QB6Y@267890|Shewanellaceae 1236|Gammaproteobacteria CET Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3,SDF k59_1046280_1 2340.JV46_21510 5.17e-84 250.0 COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,1S68X@1236|Gammaproteobacteria,1J5YH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S EVE domain - - - - - - - - - - - - EVE k59_1307188_1 1229909.NSED_01245 4.84e-92 279.0 arCOG08783@1|root,arCOG08783@2157|Archaea,41SFX@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_315001_1 1096546.WYO_4978 0.000151 43.9 COG0784@1|root,COG0784@2|Bacteria,1N1ZB@1224|Proteobacteria,2UC57@28211|Alphaproteobacteria 28211|Alphaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_315001_2 883126.HMPREF9710_04499 4.53e-45 159.0 COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,2VSTA@28216|Betaproteobacteria,4747P@75682|Oxalobacteraceae 28216|Betaproteobacteria S DUF218 domain - - - - - - - - - - - - DUF218 k59_157774_1 318167.Sfri_2763 1.22e-12 70.1 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,2QAN8@267890|Shewanellaceae 1236|Gammaproteobacteria P PFAM CBS domain containing protein mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_157774_2 1232410.KI421415_gene2976 3.43e-91 275.0 COG3271@1|root,COG3271@2|Bacteria,1RAD5@1224|Proteobacteria,42QWA@68525|delta/epsilon subdivisions,2WMVM@28221|Deltaproteobacteria,43SVV@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - Peptidase_C39,Peptidase_C39_2 k59_157774_3 502025.Hoch_5784 4.06e-79 250.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,42MPG@68525|delta/epsilon subdivisions,2WKW8@28221|Deltaproteobacteria 28221|Deltaproteobacteria HJ RimK-like ATPgrasp N-terminal domain - - - - - - - - - - - - Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK k59_315004_1 675815.VOA_002180 4.53e-08 54.3 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1XSGY@135623|Vibrionales 135623|Vibrionales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_315004_2 713586.KB900536_gene1051 1.47e-14 73.2 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1WWB3@135613|Chromatiales 135613|Chromatiales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_419424_1 1423144.Gal_02288 2.32e-22 99.4 COG1403@1|root,COG1403@2|Bacteria,1N0FM@1224|Proteobacteria,2TWQN@28211|Alphaproteobacteria 28211|Alphaproteobacteria V ERF superfamily - - - - - - - - - - - - ERF k59_732935_1 1177179.A11A3_16200 8.37e-10 59.3 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1XHMP@135619|Oceanospirillales 135619|Oceanospirillales T Chemotaxis protein histidine kinase and related chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1233_1 1049564.TevJSym_av00170 9.06e-98 297.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1J547@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX GO:0003674,GO:0003824,GO:0004812,GO:0004818,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006424,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - iEC042_1314.EC042_2616 tRNA-synt_1c k59_732938_1 867900.Celly_2511 1.51e-31 122.0 COG1409@1|root,COG1409@2|Bacteria,4NW6R@976|Bacteroidetes,1I81S@117743|Flavobacteriia 976|Bacteroidetes S Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - - - - - - - - - - Metallophos k59_576012_1 1394178.AWOO02000005_gene3590 4.48e-41 147.0 COG0499@1|root,COG0499@2|Bacteria,2GK2Q@201174|Actinobacteria,4EIAX@85012|Streptosporangiales 201174|Actinobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0000098,GO:0000166,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009087,GO:0009116,GO:0009119,GO:0009987,GO:0016020,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0019899,GO:0022610,GO:0030260,GO:0030312,GO:0033353,GO:0034641,GO:0035375,GO:0035635,GO:0036094,GO:0040007,GO:0042278,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044650,GO:0046085,GO:0046128,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0048037,GO:0050662,GO:0051186,GO:0051287,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0055086,GO:0070403,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_576012_2 570967.JMLV01000002_gene1515 1.75e-39 136.0 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2U9JM@28211|Alphaproteobacteria,2JSX8@204441|Rhodospirillales 204441|Rhodospirillales P protein affecting Mg2 Co2 transport apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_105741_1 436308.Nmar_1252 9.16e-53 171.0 arCOG08717@1|root,arCOG08717@2157|Archaea,41SFQ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - AhpC-TSA k59_1046300_1 56780.SYN_00284 2.66e-96 306.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,42PQC@68525|delta/epsilon subdivisions,2WJ8K@28221|Deltaproteobacteria 28221|Deltaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_993697_1 330214.NIDE1579 1.29e-101 311.0 COG0285@1|root,COG0285@2|Bacteria,3J0I6@40117|Nitrospirae 40117|Nitrospirae H Mur ligase middle domain - - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k59_523945_1 1523503.JPMY01000046_gene1320 1.6e-59 194.0 COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,1RPJT@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system znuC GO:0000041,GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005385,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008144,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0072509,GO:0072511,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363 - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - iSFV_1184.SFV_1859,iSF_1195.SF1867,iSFxv_1172.SFxv_2092,iS_1188.S1934 ABC_tran k59_785434_1 869213.JCM21142_41953 1.08e-45 166.0 COG0367@1|root,COG0367@2|Bacteria,4NFQ3@976|Bacteroidetes,47JSF@768503|Cytophagia 976|Bacteroidetes E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_785434_2 105559.Nwat_2531 4.63e-120 361.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,1RQ8J@1236|Gammaproteobacteria,1X0YS@135613|Chromatiales 135613|Chromatiales M Glycosyl transferase - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1098615_1 448385.sce4269 6.89e-42 152.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,42MJ9@68525|delta/epsilon subdivisions,2WJH8@28221|Deltaproteobacteria,2YU2Z@29|Myxococcales 28221|Deltaproteobacteria F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_941600_1 1268635.Loa_00764 3.64e-135 400.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1JCAE@118969|Legionellales 118969|Legionellales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD GO:0000988,GO:0000990,GO:0003674,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1203337_1 370438.PTH_0812 1.24e-106 333.0 COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,25ZYN@186807|Peptococcaceae 186801|Clostridia J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_262793_1 377629.TERTU_2487 1.59e-17 82.8 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,2PMGN@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria F Glutamine amidotransferase domain purF GO:0003674,GO:0003824,GO:0004044,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0034654,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - iAF1260.b2312,iB21_1397.B21_02197,iBWG_1329.BWG_2086,iECBD_1354.ECBD_1347,iECB_1328.ECB_02237,iECDH10B_1368.ECDH10B_2474,iECDH1ME8569_1439.ECDH1ME8569_2250,iECD_1391.ECD_02237,iECIAI1_1343.ECIAI1_2389,iECO103_1326.ECO103_2776,iECO111_1330.ECO111_3060,iECO26_1355.ECO26_3300,iECW_1372.ECW_m2501,iEKO11_1354.EKO11_1453,iETEC_1333.ETEC_2448,iEcDH1_1363.EcDH1_1344,iEcE24377_1341.EcE24377A_2606,iEcolC_1368.EcolC_1340,iJO1366.b2312,iJR904.b2312,iSF_1195.SF2388,iSFxv_1172.SFxv_2633,iSSON_1240.SSON_2370,iS_1188.S2523,iSbBS512_1146.SbBS512_E2690,iUMNK88_1353.UMNK88_2863,iWFL_1372.ECW_m2501,iY75_1357.Y75_RS12125 GATase_6,Pribosyltran k59_262793_2 1158762.KB898055_gene4 2.16e-49 169.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1WWGS@135613|Chromatiales 135613|Chromatiales E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - - ko:K10764 ko00270,ko00920,ko01100,map00270,map00920,map01100 - R01288 RC00020,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_785445_1 287.DR97_1415 2.99e-11 68.6 COG2207@1|root,COG2207@2|Bacteria,1N70D@1224|Proteobacteria,1S0HI@1236|Gammaproteobacteria,1YFZW@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_576028_1 1049564.TevJSym_ag00070 9.22e-63 201.0 COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1J7JW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Cytochrome C1 family petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C1 k59_1411674_1 1229909.NSED_04075 1.49e-54 179.0 arCOG00059@1|root,arCOG00059@2157|Archaea,41T4Y@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_315038_1 436308.Nmar_1629 6.58e-30 107.0 arCOG08792@1|root,arCOG08792@2157|Archaea,41SUG@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_315038_2 436308.Nmar_1630 3.92e-73 220.0 COG1545@1|root,arCOG01285@2157|Archaea,41SQK@651137|Thaumarchaeota 651137|Thaumarchaeota V nucleic-acid-binding protein containing a Zn-ribbon - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_315038_3 436308.Nmar_1631 7.23e-23 95.5 COG0183@1|root,arCOG01278@2157|Archaea,41SCI@651137|Thaumarchaeota 651137|Thaumarchaeota I Thiolase, N-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_471406_1 471856.Jden_0171 4e-20 94.4 COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria 201174|Actinobacteria KLT serine threonine protein kinase pknA - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_105763_2 1229909.NSED_00120 4.08e-80 248.0 COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota 651137|Thaumarchaeota H S-adenosylmethionine synthetase - - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_791526_1 644282.Deba_1209 1.71e-43 161.0 COG0617@1|root,COG0618@1|root,COG2524@1|root,COG0617@2|Bacteria,COG0618@2|Bacteria,COG2524@2|Bacteria,1MU2X@1224|Proteobacteria,42MJJ@68525|delta/epsilon subdivisions,2WJBN@28221|Deltaproteobacteria 28221|Deltaproteobacteria J CBS domain containing protein ccaA - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd k59_687065_1 1356852.N008_01550 1.24e-93 287.0 COG2227@1|root,COG2227@2|Bacteria,4NK04@976|Bacteroidetes,47NG1@768503|Cytophagia 976|Bacteroidetes H C-methyltransferase C-terminal domain - - - - - - - - - - - - Methyltransf_13,Methyltransf_14,Methyltransf_23 k59_3314_1 330214.NIDE3937 1.01e-103 333.0 COG2132@1|root,COG2132@2|Bacteria 2|Bacteria Q Multicopper oxidase - - 1.16.3.3,1.7.2.1 ko:K00368,ko:K07233,ko:K22349 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Copper-bind,Cu-oxidase_2,Cu-oxidase_3 k59_1416812_1 472759.Nhal_1604 7.38e-22 90.5 COG3577@1|root,COG3577@2|Bacteria,1MY8C@1224|Proteobacteria,1SBXM@1236|Gammaproteobacteria,1X0VU@135613|Chromatiales 135613|Chromatiales S gag-polyprotein putative aspartyl protease - - - - - - - - - - - - gag-asp_proteas k59_320428_1 1163617.SCD_n02389 1.21e-27 116.0 COG3063@1|root,COG3063@2|Bacteria 2|Bacteria NU photosynthesis - - 2.1.1.80 ko:K00575,ko:K02453,ko:K02656,ko:K20543 ko02020,ko02030,ko03070,ko05111,map02020,map02030,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko01000,ko02000,ko02035,ko02044 1.B.55.3,3.A.15 - - ANAPC5,Secretin,TPR_16,TPR_19,TPR_8 k59_528635_2 459349.CLOAM0277 9.52e-41 143.0 COG1192@1|root,COG1192@2|Bacteria,2NP2C@2323|unclassified Bacteria 2|Bacteria D Cobyrinic acid ac-diamide synthase soj GO:0008150,GO:0022603,GO:0042173,GO:0042174,GO:0043937,GO:0043939,GO:0045595,GO:0045596,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0065007 - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1364622_1 880073.Calab_2933 8.73e-23 99.4 COG2204@1|root,COG2204@2|Bacteria,2NNPN@2323|unclassified Bacteria 2|Bacteria T COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - ko:K02481,ko:K07713,ko:K07714 ko02020,map02020 M00499,M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_791541_1 156889.Mmc1_1837 3.76e-69 231.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,2TR2N@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide - - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_60410_1 1116472.MGMO_171c00150 6.14e-55 195.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1XDPM@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, phosphotransfer (Hpt) region - - - ko:K13490 ko02020,ko02025,map02020,map02025 M00509 - - ko00000,ko00001,ko00002,ko01001,ko02022 - - - CheW,HATPase_c,Hpt,Response_reg k59_1209709_1 28229.ND2E_3395 1.05e-76 236.0 COG0652@1|root,COG0652@2|Bacteria,1RBX1@1224|Proteobacteria,1SYJW@1236|Gammaproteobacteria,2Q6RR@267889|Colwelliaceae 1236|Gammaproteobacteria O Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_1103614_1 1517416.IDAT_12000 2.5e-55 192.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RT11@1236|Gammaproteobacteria,2QFA7@267893|Idiomarinaceae 1236|Gammaproteobacteria EU Dienelactone hydrolase family - - - - - - - - - - - - DPPIV_N,Gmad1,PD40,Peptidase_S9,Peptidase_S9_N k59_635003_1 648885.KB316283_gene3470 0.000905 45.1 COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,2TW0S@28211|Alphaproteobacteria,1JVAF@119045|Methylobacteriaceae 28211|Alphaproteobacteria T PFAM CBS domain containing protein - - - - - - - - - - - - CBS k59_635005_1 1453501.JELR01000001_gene1941 1e-10 67.8 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,464XP@72275|Alteromonadaceae 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_161197_1 439493.PB7211_783 2.62e-14 72.8 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,4BRA7@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q TIGRFAM TRAP transporter, DctM subunit - - - - - - - - - - - - DctM,DctQ k59_161197_2 270374.MELB17_21790 2.57e-26 105.0 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S3PH@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_110469_1 349124.Hhal_0419 1.71e-63 207.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,1RRUS@1236|Gammaproteobacteria 1236|Gammaproteobacteria L hmm pf01609 - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_791568_2 1123368.AUIS01000012_gene783 1.92e-24 96.7 2EC4Z@1|root,3363S@2|Bacteria,1N9YG@1224|Proteobacteria,1SSSK@1236|Gammaproteobacteria,2NCZQ@225057|Acidithiobacillales 225057|Acidithiobacillales - - - - - - - - - - - - - - - k59_215344_1 240016.ABIZ01000001_gene1388 7.52e-40 149.0 COG4249@1|root,COG4249@2|Bacteria,46VIY@74201|Verrucomicrobia,2IUAP@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Peptidase C14 caspase catalytic subunit p20 - - - - - - - - - - - - - k59_215344_2 1191523.MROS_2306 4.02e-12 73.6 COG1572@1|root,COG2304@1|root,COG1572@2|Bacteria,COG2304@2|Bacteria 2|Bacteria IU oxidoreductase activity - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - DUF2135,DUF2828,VIT k59_528660_1 444861.E3SPG5_9CAUD 8.6e-22 88.2 4QEP0@10239|Viruses,4QYH8@35237|dsDNA viruses no RNA stage,4QQFZ@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1416850_1 640081.Dsui_1390 7.81e-14 73.6 2E6RE@1|root,331BH@2|Bacteria,1N8K0@1224|Proteobacteria,2VWUF@28216|Betaproteobacteria,2KXGE@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_1312243_1 1380394.JADL01000011_gene3942 2.26e-164 472.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TU6U@28211|Alphaproteobacteria,2JPVH@204441|Rhodospirillales 204441|Rhodospirillales E Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_1261812_1 279714.FuraDRAFT_0748 4.2e-58 202.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,2KSUD@206351|Neisseriales 206351|Neisseriales P Cation transporter/ATPase, N-terminus - - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_1209732_1 1267535.KB906767_gene1250 7.38e-71 239.0 COG0587@1|root,COG0587@2|Bacteria,3Y3YK@57723|Acidobacteria,2JKQG@204432|Acidobacteriia 204432|Acidobacteriia L Belongs to the DNA polymerase type-C family. DnaE2 subfamily - - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_320469_1 1479237.JMLY01000001_gene2626 1.23e-82 265.0 COG2312@1|root,COG2518@1|root,COG2312@2|Bacteria,COG2518@2|Bacteria,1MU2S@1224|Proteobacteria,1RNDR@1236|Gammaproteobacteria,46A50@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - Erythro_esteras,PCMT k59_267806_1 234267.Acid_4465 2.08e-13 73.2 COG3547@1|root,COG3547@2|Bacteria,3Y5SI@57723|Acidobacteria 57723|Acidobacteria L transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1573160_1 644801.Psest_4225 4e-106 327.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1Z1DQ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdZ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_581049_1 330214.NIDE3019 5.05e-40 145.0 COG0438@1|root,COG0438@2|Bacteria,3J19R@40117|Nitrospirae 40117|Nitrospirae M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1519288_1 765914.ThisiDRAFT_1476 7.1e-67 214.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1WVXW@135613|Chromatiales 135613|Chromatiales J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_161210_1 1207063.P24_03855 5.02e-164 470.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQAV@204441|Rhodospirillales 204441|Rhodospirillales C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_528671_1 1048339.KB913029_gene2868 3.29e-36 134.0 COG0500@1|root,COG2226@2|Bacteria,2GNXF@201174|Actinobacteria,4ETXJ@85013|Frankiales 201174|Actinobacteria Q Putative methyltransferase - - 2.1.1.288 ko:K15942 ko01057,ko01130,map01057,map01130 M00781 R06675,R06680 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_25 k59_1209754_1 298654.FraEuI1c_5558 1.83e-26 110.0 COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria 201174|Actinobacteria S Pfam Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1469963_1 1026882.MAMP_02503 5.33e-10 59.3 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,460C8@72273|Thiotrichales 72273|Thiotrichales E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1469963_2 713586.KB900536_gene1667 1.05e-50 164.0 COG0614@1|root,COG0614@2|Bacteria,1N7EM@1224|Proteobacteria,1S6E7@1236|Gammaproteobacteria,1X17N@135613|Chromatiales 135613|Chromatiales P PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_3 k59_687145_1 536233.CLO_3872 4.31e-07 57.4 COG0613@1|root,COG1387@1|root,COG5263@1|root,COG0613@2|Bacteria,COG1387@2|Bacteria,COG5263@2|Bacteria,1VUGT@1239|Firmicutes,25F7D@186801|Clostridia,36UY8@31979|Clostridiaceae 186801|Clostridia E Belongs to the peptidase S8 family - - - - - - - - - - - - Big_2,CHB_HEX_C_1,DUF3604 k59_161212_1 338963.Pcar_2159 1.49e-27 107.0 COG4970@1|root,COG4970@2|Bacteria,1N7RS@1224|Proteobacteria,43EXT@68525|delta/epsilon subdivisions,2WTA0@28221|Deltaproteobacteria,43VJT@69541|Desulfuromonadales 28221|Deltaproteobacteria NU Type II transport protein GspH - - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_528680_1 247634.GPB2148_1903 6.12e-52 183.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,1J5AG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1573175_1 1437329.A0A0A8KWW5_9CAUD 4.93e-17 84.3 4QARC@10239|Viruses,4QV4E@35237|dsDNA viruses no RNA stage,4QPDS@28883|Caudovirales,4QP0H@10744|Podoviridae 10744|Podoviridae S nucleic acid binding - - - - - - - - - - - - - k59_1261835_1 883.DvMF_2782 1.31e-25 108.0 COG1122@1|root,COG1122@2|Bacteria,1QUK5@1224|Proteobacteria,43BK3@68525|delta/epsilon subdivisions,2X6XY@28221|Deltaproteobacteria,2MH88@213115|Desulfovibrionales 28221|Deltaproteobacteria P ABC transporter tupC - 3.6.3.55 ko:K06857 ko02010,map02010 M00186 R10531 RC00002 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.2,3.A.1.6.4 - - ABC_tran k59_1261835_2 1123400.KB904771_gene3348 3.6e-96 287.0 COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,1RYSQ@1236|Gammaproteobacteria,460PG@72273|Thiotrichales 72273|Thiotrichales H ABC-type tungstate transport system - - - ko:K05773 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - BPD_transp_1 k59_1261835_3 395493.BegalDRAFT_0169 8.05e-110 324.0 COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,1RZ6B@1236|Gammaproteobacteria,4622J@72273|Thiotrichales 72273|Thiotrichales H PBP superfamily domain - - - ko:K05772 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - PBP_like_2 k59_842355_2 765914.ThisiDRAFT_2349 8.78e-49 164.0 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,1RMW5@1236|Gammaproteobacteria,1WXKZ@135613|Chromatiales 135613|Chromatiales P Plays a role in the regulation of phosphate uptake - - - ko:K02039 - - - - ko00000 - - - PhoU k59_635057_2 671143.DAMO_0814 6.41e-39 134.0 COG1487@1|root,COG1487@2|Bacteria 2|Bacteria S nuclease activity - - - ko:K18828 - - - - ko00000,ko01000,ko02048,ko03016 - - - PIN k59_737755_1 392500.Swoo_3954 6.01e-77 245.0 COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria,2QAVG@267890|Shewanellaceae 1236|Gammaproteobacteria C PFAM NADH Ubiquinone plastoquinone (complex I) - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M,Proton_antipo_N k59_60493_1 519989.ECTPHS_04009 5.71e-74 238.0 COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,1RRIA@1236|Gammaproteobacteria,1X0CC@135613|Chromatiales 135613|Chromatiales E 7 transmembrane helices usually fused to an inactive transglutaminase - - - - - - - - - - - - 7TM_transglut,Transglut_i_TM k59_528693_1 398525.KB900701_gene1614 3.69e-05 45.1 COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,2TSSU@28211|Alphaproteobacteria,3JVUZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_528693_2 479431.Namu_2620 6.7e-05 47.4 COG0748@1|root,COG0748@2|Bacteria,2I6JE@201174|Actinobacteria 201174|Actinobacteria P Pfam:DUF385 - - - - - - - - - - - - F420H2_quin_red k59_528693_3 1123279.ATUS01000003_gene374 2.73e-06 50.4 COG4689@1|root,COG4689@2|Bacteria,1R7YD@1224|Proteobacteria,1S1RP@1236|Gammaproteobacteria,1J8DF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Acetoacetate decarboxylase (ADC) - - - - - - - - - - - - ADC k59_1469997_3 1493511.A0A0E3F0H5_9CAUD 4.08e-14 65.9 4QDUK@10239|Viruses,4QRKA@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1469998_1 479434.Sthe_2989 5.22e-45 163.0 COG0477@1|root,COG2814@2|Bacteria,2G6D7@200795|Chloroflexi 2|Bacteria EGP Major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_3 k59_3341_1 1493511.A0A0E3FRK0_9CAUD 9.87e-25 96.3 4QAZF@10239|Viruses,4QPH6@28883|Caudovirales,4QI08@10662|Myoviridae 10662|Myoviridae S Protein of unknwon function (DUF3310) - - - - - - - - - - - - - k59_3341_2 444860.E3SJ31_9CAUD 1.18e-110 321.0 4QB2Z@10239|Viruses,4QWQN@35237|dsDNA viruses no RNA stage,4QPYN@28883|Caudovirales,4QHWJ@10662|Myoviridae 10662|Myoviridae S gp45 sliding clamp, C terminal - GO:0008150,GO:0016032,GO:0019058,GO:0019079,GO:0039686,GO:0039693,GO:0044403,GO:0044419,GO:0051704 - - - - - - - - - - - k59_1261872_1 1392502.JNIO01000002_gene323 8.02e-08 55.1 COG2103@1|root,COG2103@2|Bacteria,1TPSF@1239|Firmicutes,4H28B@909932|Negativicutes 909932|Negativicutes G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate murQ - 4.2.1.126 ko:K07106 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - - SIS,SIS_2 k59_372182_1 1267533.KB906738_gene2439 3.09e-14 82.0 COG0392@1|root,COG0558@1|root,COG0392@2|Bacteria,COG0558@2|Bacteria 2|Bacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - CDP-OH_P_transf,LPG_synthase_TM k59_1209799_1 1218084.BBJK01000153_gene7621 5.34e-96 313.0 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VSSJ@28216|Betaproteobacteria,1K5FA@119060|Burkholderiaceae 28216|Betaproteobacteria T PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - AAA_16,BTAD,Guanylate_cyc,SAM_1,TPR_12,TPR_8,Trans_reg_C k59_528707_1 267608.RSc2658 7.14e-21 90.9 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,2VIR4@28216|Betaproteobacteria,1K2WY@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase opaA - 3.5.5.1 ko:K01501,ko:K11206 ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120 - R00540,R01887,R03093,R03542,R05591,R07855 RC00315,RC00325,RC00617,RC00959,RC02811 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_528707_2 1492922.GY26_10890 0.000274 45.4 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1J4SY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function yhdP GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - - - - - - - - - - AsmA_2,DUF3971 k59_60516_1 247490.KSU1_C1184 3.76e-109 327.0 COG0150@1|root,COG0150@2|Bacteria,2IYCG@203682|Planctomycetes 203682|Planctomycetes F PFAM AIR synthase related protein purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_635103_1 1462526.BN990_00970 3.54e-43 150.0 COG1209@1|root,COG1209@2|Bacteria,1V301@1239|Firmicutes,4H9R0@91061|Bacilli,4C5EF@84406|Virgibacillus 91061|Bacilli M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis spsI - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_476598_1 1454004.AW11_02647 8.43e-12 63.5 2E80B@1|root,332EM@2|Bacteria,1N7PZ@1224|Proteobacteria,2VVZX@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_424902_2 666684.AfiDRAFT_1463 4.53e-53 179.0 COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2TQN7@28211|Alphaproteobacteria,3JQSS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O OsmC-like protein MA20_16590 - - ko:K06889,ko:K07397 - - - - ko00000 - - - Hydrolase_4,OsmC k59_424906_1 1287116.X734_04375 1.29e-27 107.0 COG2808@1|root,COG2808@2|Bacteria,1N1B9@1224|Proteobacteria,2VA2A@28211|Alphaproteobacteria,43PSU@69277|Phyllobacteriaceae 28211|Alphaproteobacteria K Putative FMN-binding domain - - - - - - - - - - - - FMN_bind_2 k59_1470425_1 459349.CLOAM1140 3.43e-36 131.0 COG0087@1|root,COG0087@2|Bacteria,2NPAI@2323|unclassified Bacteria 2|Bacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015934,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031325,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000232,GO:2000234 - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_1470425_2 1101191.KI912577_gene1768 0.000321 43.5 COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,2TSBW@28211|Alphaproteobacteria,1JSAZ@119045|Methylobacteriaceae 28211|Alphaproteobacteria J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit ftsJ - 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_529047_1 1125863.JAFN01000001_gene3312 1.91e-33 120.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_529047_2 1150469.RSPPHO_01240 1.46e-12 63.2 COG1841@1|root,COG1841@2|Bacteria,1PU2S@1224|Proteobacteria,2UF55@28211|Alphaproteobacteria,2JTU5@204441|Rhodospirillales 204441|Rhodospirillales J Ribosomal protein L30 rpmD - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_529047_3 1203605.HMPREF1531_00163 3.83e-10 58.5 COG0200@1|root,COG0200@2|Bacteria,2II6M@201174|Actinobacteria,4DQND@85009|Propionibacteriales 201174|Actinobacteria J binds to the 23S rRNA rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_635549_1 1469245.JFBG01000014_gene2028 4.5e-87 273.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1WWDG@135613|Chromatiales 1236|Gammaproteobacteria E TIGRFAM Acetolactate synthase, large subunit, biosynthetic - - 1.2.5.1,2.2.1.6 ko:K00156,ko:K01652 ko00290,ko00620,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00620,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R03145,R04672,R04673,R08648 RC00027,RC00106,RC00860,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_320986_1 935261.JAGL01000016_gene2793 2.94e-20 94.7 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2TR8K@28211|Alphaproteobacteria,43HWU@69277|Phyllobacteriaceae 28211|Alphaproteobacteria M Cyclopropane-fatty-acyl-phospholipid synthase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_1156041_1 1380394.JADL01000008_gene3522 3.69e-51 175.0 COG3395@1|root,COG3395@2|Bacteria,1MW4G@1224|Proteobacteria,2TS85@28211|Alphaproteobacteria,2JQNX@204441|Rhodospirillales 204441|Rhodospirillales S Putative sugar-binding N-terminal domain - - 2.7.1.217 ko:K21948 - - R11706,R11707 - ko00000,ko01000 - - - DUF1357_C,DUF1537 k59_635555_1 1003195.SCAT_4941 2.8e-27 110.0 COG1232@1|root,COG1232@2|Bacteria,2I2Z5@201174|Actinobacteria 201174|Actinobacteria H squalene-associated FAD-dependent desaturase hopC - - - - - - - - - - - Amino_oxidase k59_635555_2 1394178.AWOO02000022_gene7136 3.87e-24 103.0 COG1657@1|root,COG1657@2|Bacteria,2GM7H@201174|Actinobacteria,4EFV5@85012|Streptosporangiales 201174|Actinobacteria I Squalene-hopene cyclase N-terminal domain shc - 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 - R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 - - - SQHop_cyclase_C,SQHop_cyclase_N k59_792156_2 240015.ACP_2341 9.01e-60 194.0 COG0040@1|root,COG0040@2|Bacteria,3Y31Q@57723|Acidobacteria,2JICU@204432|Acidobacteriia 204432|Acidobacteriia E ATP phosphoribosyltransferase hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_795746_1 59538.XP_005973943.1 1.45e-58 192.0 COG1028@1|root,KOG0725@2759|Eukaryota 2759|Eukaryota IQ oxidation-reduction process - - - - - - - - - - - - adh_short k59_897682_1 436308.Nmar_0348 5.32e-79 263.0 COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA2 - 2.7.7.6 ko:K03041 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1473652_1 1232437.KL661971_gene4874 2.31e-07 52.0 COG2203@1|root,COG2203@2|Bacteria,1R6PX@1224|Proteobacteria,42NG9@68525|delta/epsilon subdivisions,2WKCE@28221|Deltaproteobacteria,2MING@213118|Desulfobacterales 28221|Deltaproteobacteria T ANTAR - - - - - - - - - - - - ANTAR,GAF_2 k59_1473652_2 83406.HDN1F_00480 1.49e-13 73.2 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K07028 - - - - ko00000 - - - AAA_33,APH k59_4514_1 713586.KB900536_gene1379 5.65e-48 170.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1WWDS@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_1054346_1 338963.Pcar_2171 3e-16 82.4 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,43T20@69541|Desulfuromonadales 28221|Deltaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1054346_2 1173024.KI912154_gene875 1.02e-15 75.1 COG0500@1|root,COG2226@2|Bacteria,1FZVZ@1117|Cyanobacteria,1JJV7@1189|Stigonemataceae 1117|Cyanobacteria Q Dimerisation domain - - - - - - - - - - - - Dimerisation2,Methyltransf_2 k59_270797_1 765913.ThidrDRAFT_3732 3.62e-51 179.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1WXMX@135613|Chromatiales 135613|Chromatiales U Type II secretory pathway, component ExeA - - - - - - - - - - - - AAA_22,OmpA k59_113274_1 795359.TOPB45_1456 7.37e-82 259.0 COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2GH4Q@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria H Belongs to the precorrin methyltransferase family - - 2.1.1.107,4.2.1.75 ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4,TP_methylase k59_375348_1 1123519.PSJM300_03780 1.59e-24 106.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1Z107@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S Zn-dependent proteases and their inactivated homologs pmbA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1001338_1 717774.Marme_4151 4.86e-72 228.0 COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,1SKPD@1236|Gammaproteobacteria,1XHT4@135619|Oceanospirillales 135619|Oceanospirillales P Belongs to the ABC transporter superfamily dppF - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_1106682_2 204669.Acid345_1303 3.8e-10 61.6 COG1007@1|root,COG1007@2|Bacteria,3Y3PV@57723|Acidobacteria,2JIT3@204432|Acidobacteriia 204432|Acidobacteriia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1213428_2 794903.OPIT5_16970 1.32e-67 218.0 28IIB@1|root,2Z8JE@2|Bacteria 2|Bacteria S Glycosyltransferase family 10 (fucosyltransferase) C-term - - - - - - - - - - - - Glyco_transf_10 k59_1001349_1 574087.Acear_2337 0.000244 47.8 COG1664@1|root,COG1664@2|Bacteria,1VEVU@1239|Firmicutes,24QT5@186801|Clostridia,3WAX3@53433|Halanaerobiales 186801|Clostridia M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_1001349_2 745014.OMB55_00024990 4.4e-13 67.0 COG3917@1|root,COG3917@2|Bacteria,1R3XW@1224|Proteobacteria,1SSU7@1236|Gammaproteobacteria 1236|Gammaproteobacteria G DSBA-like thioredoxin domain - - - - - - - - - - - - DSBA k59_1314933_1 1535422.ND16A_1248 1.37e-05 47.4 COG0845@1|root,COG0845@2|Bacteria,1MV1T@1224|Proteobacteria,1RQTS@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3,HlyD_D23 k59_1314933_2 1123073.KB899241_gene3502 9.77e-83 278.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X5MD@135614|Xanthomonadales 135614|Xanthomonadales V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_427454_1 1411685.U062_01730 3.73e-184 524.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1J53P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Ammonium Transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_690422_1 663610.JQKO01000012_gene3141 6.91e-27 112.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria,3NAAZ@45404|Beijerinckiaceae 28211|Alphaproteobacteria C Cysteine-rich domain glcF GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7 k59_375372_1 243233.MCA1833 3.69e-65 212.0 COG3367@1|root,COG3367@2|Bacteria,1MVEX@1224|Proteobacteria,1RNVG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF1611_N) Rossmann-like domain - - - - - - - - - - - - DUF1611,DUF1611_N k59_690425_1 1120792.JAFV01000001_gene1302 2.52e-14 74.3 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2TRMT@28211|Alphaproteobacteria,36XJW@31993|Methylocystaceae 28211|Alphaproteobacteria E Semialdehyde dehydrogenase, NAD binding domain argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_690425_3 1049564.TevJSym_as00080 4.32e-90 271.0 28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria,1RRWN@1236|Gammaproteobacteria,1J4YB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4126) - - - - - - - - - - - - DUF4126,SHOCT k59_1001365_1 395493.BegalDRAFT_0484 1.97e-97 304.0 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,45ZSF@72273|Thiotrichales 72273|Thiotrichales E arginine decarboxylase speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_1367692_1 314254.OA2633_01821 1.8e-21 92.0 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,2TSHM@28211|Alphaproteobacteria,43WNE@69657|Hyphomonadaceae 28211|Alphaproteobacteria S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_1367692_2 1177928.TH2_14204 9.23e-12 67.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2TTIA@28211|Alphaproteobacteria,2JSAS@204441|Rhodospirillales 204441|Rhodospirillales J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc - 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_1576074_2 926560.KE387023_gene1494 2.26e-07 55.1 COG3629@1|root,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,BTAD k59_1213450_1 631454.N177_0502 2.66e-90 280.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,1JNPA@119043|Rhodobiaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter TctA family MA20_43210 - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_1265700_1 317025.Tcr_0310 6.22e-80 242.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,460IG@72273|Thiotrichales 72273|Thiotrichales J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_1265700_2 948565.AFFP02000030_gene1194 1.08e-31 114.0 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,1S5V2@1236|Gammaproteobacteria,1Y8P7@135625|Pasteurellales 135625|Pasteurellales J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_113317_1 485918.Cpin_3622 2.74e-22 102.0 COG3209@1|root,COG3209@2|Bacteria,4PKBQ@976|Bacteroidetes,1J0N1@117747|Sphingobacteriia 976|Bacteroidetes M conserved repeat domain protein - - - - - - - - - - - - CHU_C,Calx-beta,DUF11,SprB k59_795838_1 1085623.GNIT_0327 3.9e-70 234.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,464B1@72275|Alteromonadaceae 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1576082_2 436308.Nmar_1457 4.05e-51 171.0 arCOG01778@1|root,arCOG01778@2157|Archaea,41SXW@651137|Thaumarchaeota 651137|Thaumarchaeota Q O-methyltransferase - - - - - - - - - - - - Methyltransf_31 k59_375391_1 1282876.BAOK01000001_gene1964 1.17e-54 188.0 COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,2TSJC@28211|Alphaproteobacteria,4BRKG@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria CP Proton-conducting membrane transporter nuoL3 - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_375391_2 1121015.N789_10980 2.34e-10 61.6 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria,1X633@135614|Xanthomonadales 135614|Xanthomonadales O glycoprotease - - - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 k59_1521261_2 1384056.N787_01450 5.88e-34 123.0 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,1RS9K@1236|Gammaproteobacteria,1X631@135614|Xanthomonadales 135614|Xanthomonadales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain msrQ - - ko:K17247 - - - - ko00000 - - - Ferric_reduct k59_427475_1 997346.HMPREF9374_0156 7.96e-83 259.0 COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,4HC7T@91061|Bacilli,27BH5@186824|Thermoactinomycetaceae 91061|Bacilli E Amino-transferase class IV ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_1054403_1 864051.BurJ1DRAFT_3974 4.41e-40 148.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2VMU1@28216|Betaproteobacteria,1KMEA@119065|unclassified Burkholderiales 28216|Betaproteobacteria M PFAM Glycosyl transferases group 1 epsN - 2.4.1.348 ko:K12995 - - - - ko00000,ko01000,ko01003,ko01005 - GT4 - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_1420118_1 1049564.TevJSym_ca00050 7.73e-99 316.0 COG1033@1|root,COG2834@1|root,COG1033@2|Bacteria,COG2834@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1J96Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M MMPL family VP1286 - - ko:K07003 - - - - ko00000 - - - MMPL k59_164182_2 1340493.JNIF01000003_gene4699 1.69e-81 270.0 COG1138@1|root,COG1138@2|Bacteria,3Y40N@57723|Acidobacteria 57723|Acidobacteria O PFAM Cytochrome c assembly protein - - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_1521266_1 340099.Teth39_1888 5.41e-69 227.0 COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,248II@186801|Clostridia,42EMC@68295|Thermoanaerobacterales 186801|Clostridia H PFAM aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_428062_1 574966.KB898649_gene211 3.21e-103 312.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,1RMDF@1236|Gammaproteobacteria,1XIU2@135619|Oceanospirillales 135619|Oceanospirillales P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_428062_2 768066.HELO_1694 1.18e-30 114.0 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1XIT9@135619|Oceanospirillales 135619|Oceanospirillales E phosphoserine phosphatase - - - - - - - - - - - - HAD k59_796707_1 189753.AXAS01000077_gene369 4.5e-50 179.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,3JRIE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_480794_1 1472418.BBJC01000002_gene1009 4.96e-15 77.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2TSZN@28211|Alphaproteobacteria 28211|Alphaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_480794_2 237368.SCABRO_00861 1.58e-35 123.0 COG3288@1|root,COG3288@2|Bacteria,2J0SW@203682|Planctomycetes 203682|Planctomycetes C COG3288 NAD NADP transhydrogenase alpha subunit - - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB_4TM k59_480794_3 864702.OsccyDRAFT_0323 3.04e-28 114.0 COG1282@1|root,COG1282@2|Bacteria,1G2AX@1117|Cyanobacteria,1H8G7@1150|Oscillatoriales 1117|Cyanobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_1521662_1 395495.Lcho_0175 2.86e-22 93.6 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2VI8C@28216|Betaproteobacteria,1KJNR@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_1521662_2 1168065.DOK_08069 2.44e-24 102.0 COG0501@1|root,COG0501@2|Bacteria,1R0V5@1224|Proteobacteria,1SBIF@1236|Gammaproteobacteria 1236|Gammaproteobacteria O peptidase M48, Ste24p - - - - - - - - - - - - Peptidase_M48 k59_1266475_1 502025.Hoch_2048 1.8e-89 283.0 COG0121@1|root,COG1305@1|root,COG0121@2|Bacteria,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,42PJK@68525|delta/epsilon subdivisions,2WMCS@28221|Deltaproteobacteria,2YU92@29|Myxococcales 28221|Deltaproteobacteria E Bacterial transglutaminase-like N-terminal region - - - - - - - - - - - - Bact_transglu_N,GATase_4,Transglut_core k59_1002054_1 1123023.JIAI01000002_gene4645 2.36e-88 268.0 COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1420914_1 1469245.JFBG01000013_gene1935 5.95e-168 483.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,1RNFN@1236|Gammaproteobacteria,1WZY2@135613|Chromatiales 135613|Chromatiales C Aldehyde dehydrogenase family - - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1315559_1 1283300.ATXB01000002_gene2925 1.9e-71 235.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1XE1B@135618|Methylococcales 135618|Methylococcales C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_1214078_1 911008.GLAD_02556 1.21e-19 87.4 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Glycerol-3-phosphate dehydrogenase gpsA GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - iJN746.PP_4169,iSFV_1184.SFV_3923 NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_1214078_2 631362.Thi970DRAFT_02333 7.81e-23 93.6 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1WY33@135613|Chromatiales 135613|Chromatiales U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB - - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_532322_1 1229909.NSED_00230 5.81e-29 106.0 arCOG10515@1|root,arCOG10515@2157|Archaea,41TAP@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_532322_2 1229909.NSED_00225 5.4e-31 110.0 COG1254@1|root,arCOG01674@2157|Archaea,41SRG@651137|Thaumarchaeota 651137|Thaumarchaeota C Acylphosphatase - - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase k59_532322_3 436308.Nmar_0102 7.35e-46 153.0 COG0090@1|root,arCOG04067@2157|Archaea,41SCT@651137|Thaumarchaeota 651137|Thaumarchaeota J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rpl2 - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_271495_1 502025.Hoch_5429 1.45e-57 202.0 COG4206@1|root,COG4206@2|Bacteria,1R47X@1224|Proteobacteria,43BZA@68525|delta/epsilon subdivisions,2X7A1@28221|Deltaproteobacteria,2YU9I@29|Myxococcales 28221|Deltaproteobacteria M TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1055021_1 330214.NIDE3027 2.15e-23 95.9 COG0463@1|root,COG0463@2|Bacteria,3J0M5@40117|Nitrospirae 40117|Nitrospirae M biosynthesis glycosyltransferase - - - - - - - - - - - - Glycos_transf_2 k59_1055021_2 153721.MYP_2690 1.42e-39 140.0 COG0463@1|root,COG0463@2|Bacteria,4NEZP@976|Bacteroidetes,47MB5@768503|Cytophagia 976|Bacteroidetes M Glycosyl transferase, family 2 - - - - - - - - - - - - Glyco_tranf_2_4 k59_532323_1 751994.AGIG01000034_gene530 4.64e-77 236.0 COG5285@1|root,COG5285@2|Bacteria,1MWD5@1224|Proteobacteria,1RSBY@1236|Gammaproteobacteria,1JBEP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Phytanoyl-CoA dioxygenase (PhyH) ectD - 1.14.11.55 ko:K10674 ko00260,ko01120,map00260,map01120 - R08050 RC00661 ko00000,ko00001,ko01000 - - - PhyH k59_219138_1 1207063.P24_09931 7.39e-100 298.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TREB@28211|Alphaproteobacteria,2JQDG@204441|Rhodospirillales 204441|Rhodospirillales S AAA domain (dynein-related subfamily) - - - - - - - - - - - - AAA,AAA_5 k59_898395_1 1122611.KB903965_gene5028 1.81e-82 255.0 COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4EH5G@85012|Streptosporangiales 201174|Actinobacteria I Thiolase, C-terminal domain fadA6 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_65245_1 1280944.HY17_01505 7.15e-06 48.1 COG1983@1|root,COG1983@2|Bacteria,1NECC@1224|Proteobacteria,2UEYZ@28211|Alphaproteobacteria,43Y1I@69657|Hyphomonadaceae 28211|Alphaproteobacteria KT phage shock protein C - - - ko:K03973 - - - - ko00000,ko02048,ko03000 - - - PspC k59_65245_2 1380394.JADL01000001_gene2267 1.01e-07 53.9 COG1983@1|root,COG1983@2|Bacteria,1NECC@1224|Proteobacteria,2UEYZ@28211|Alphaproteobacteria,2JTP5@204441|Rhodospirillales 204441|Rhodospirillales KT PspC domain - - - ko:K03973 - - - - ko00000,ko02048,ko03000 - - - PspC k59_741258_1 244447.XP_008316061.1 6.38e-08 55.5 COG0657@1|root,KOG4627@2759|Eukaryota,39TRG@33154|Opisthokonta,3BI49@33208|Metazoa,3CVFW@33213|Bilateria,486R6@7711|Chordata,495R2@7742|Vertebrata,49Q12@7898|Actinopterygii 33208|Metazoa E Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites AFMID GO:0003674,GO:0003824,GO:0004061,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.9 ko:K01432 ko00380,ko00630,ko01100,map00380,map00630,map01100 M00038 R00988,R01959,R04911 RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_3 k59_1368301_1 331869.BAL199_10567 3.2e-38 132.0 COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,2UC47@28211|Alphaproteobacteria,4BQW9@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Succinate dehydrogenase Fumarate reductase sdhC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_1368301_2 6412.HelroP93683 1.01e-09 57.0 KOG3245@1|root,KOG3245@2759|Eukaryota,3A8BP@33154|Opisthokonta,3BUKS@33208|Metazoa,3DANG@33213|Bilateria 33208|Metazoa S respiratory chain complex II assembly C6orf57 GO:0000104,GO:0000302,GO:0001654,GO:0002376,GO:0003407,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005749,GO:0006091,GO:0006950,GO:0006952,GO:0006955,GO:0006979,GO:0006996,GO:0007005,GO:0007275,GO:0007423,GO:0008150,GO:0008152,GO:0008177,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016635,GO:0019866,GO:0022607,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0032991,GO:0033108,GO:0033554,GO:0034552,GO:0034553,GO:0034599,GO:0034614,GO:0034622,GO:0042221,GO:0043010,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045087,GO:0045257,GO:0045273,GO:0045281,GO:0045283,GO:0045333,GO:0048513,GO:0048731,GO:0048856,GO:0050896,GO:0051716,GO:0055114,GO:0060041,GO:0065003,GO:0070469,GO:0070887,GO:0071840,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901700,GO:1901701,GO:1902494,GO:1990204 - - - - - - - - - - DUF1674 k59_1480294_1 436308.Nmar_1532 9.8e-52 165.0 arCOG10590@1|root,arCOG10590@2157|Archaea,41SSG@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1480294_2 436308.Nmar_1531 3.02e-12 65.5 COG0533@1|root,arCOG01185@2157|Archaea,41SJJ@651137|Thaumarchaeota 651137|Thaumarchaeota T Mn2 -dependent serine threonine protein kinase - - 2.7.11.1 ko:K08851 - - - - ko00000,ko01000,ko01001,ko03016 - - - Pkinase k59_275816_1 247490.KSU1_C1435 5.16e-37 137.0 COG1752@1|root,COG1752@2|Bacteria,2J4RT@203682|Planctomycetes 203682|Planctomycetes S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_275816_2 177439.DP3020 4.87e-21 87.4 2DJ8V@1|root,3050U@2|Bacteria,1RE7U@1224|Proteobacteria 1224|Proteobacteria - - - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - - k59_1318936_1 765914.ThisiDRAFT_0180 4.71e-98 301.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales 135613|Chromatiales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_70882_1 1379270.AUXF01000003_gene3735 5.11e-12 60.8 COG0361@1|root,COG0361@2|Bacteria,1ZV5Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex - - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_70882_2 1191523.MROS_0450 5.52e-07 48.9 COG0828@1|root,COG0828@2|Bacteria 2|Bacteria J Belongs to the bacterial ribosomal protein bS21 family rpsU GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 k59_70882_3 861299.J421_1914 6.67e-32 115.0 COG1278@1|root,COG1278@2|Bacteria 2|Bacteria K Cold shock - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_1059466_1 1279038.KB907338_gene1085 6.52e-13 71.6 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,2JQBN@204441|Rhodospirillales 204441|Rhodospirillales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1059466_2 1121380.JNIW01000004_gene631 3.36e-15 77.8 COG3424@1|root,COG3424@2|Bacteria,1WKVP@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus Q PFAM Chalcone and stilbene synthases, N-terminal domain - - - ko:K16167 - - - - ko00000,ko01008 - - - Chal_sti_synt_C,Chal_sti_synt_N k59_70893_1 983544.Lacal_0310 6.62e-65 222.0 COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,1IJ7V@117743|Flavobacteriia 976|Bacteroidetes P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787,ko:K15726 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 - - ACR_tran k59_645568_1 1182590.BN5_01463 7.81e-67 212.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,1RNWH@1236|Gammaproteobacteria,1YDID@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria KT Transcriptional regulatory protein, C terminal cusR GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0042221,GO:0042802,GO:0046688,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_119057_2 349124.Hhal_1047 2.64e-18 83.2 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1WWR6@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator, LysR - - - ko:K21703 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1634401_1 4641.GSMUA_Achr6P05690_001 1.05e-23 100.0 COG1233@1|root,KOG4254@2759|Eukaryota,37K3E@33090|Viridiplantae,3G9QZ@35493|Streptophyta,3KPMQ@4447|Liliopsida 35493|Streptophyta H Pyridine nucleotide-disulfide oxidoreductase domain-containing protein - - - - - - - - - - - - Amino_oxidase,DAO,NAD_binding_8 k59_1634401_2 935261.JAGL01000019_gene595 1.42e-27 116.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,43GY1@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_1581024_1 467661.RKLH11_1932 2.3e-82 261.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria 28211|Alphaproteobacteria P arylsulfatase A - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - DUF4994,Sulfatase,Sulfatase_C k59_328535_1 1234364.AMSF01000027_gene3481 1.43e-59 207.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1X48C@135614|Xanthomonadales 135614|Xanthomonadales L dna polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_6800_1 322710.Avin_28210 5.08e-23 96.7 COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,1S9FW@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0032940,GO:0033036,GO:0034613,GO:0042597,GO:0042886,GO:0042953,GO:0042954,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0051641,GO:0070727,GO:0071702,GO:0071705,GO:0072321,GO:0072322,GO:0072323,GO:0072657 - ko:K03634 - - - - ko00000 - - - LolA k59_6800_2 349124.Hhal_1396 7.27e-27 110.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales 135613|Chromatiales D DNA segregation ATPase FtsK SpoIIIE - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1427627_2 999549.KI421514_gene38 1.82e-27 112.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2TQUE@28211|Alphaproteobacteria,27ZIW@191028|Leisingera 28211|Alphaproteobacteria F Adenylosuccinate lyase C-terminus purB GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_537266_1 756272.Plabr_4330 4.9e-63 209.0 COG1032@1|root,COG1032@2|Bacteria,2J1W3@203682|Planctomycetes 203682|Planctomycetes C B12 binding domain - - - - - - - - - - - - B12-binding,DUF4080,Radical_SAM k59_1581818_2 34506.g2413 1.27e-28 117.0 2E0SH@1|root,2S868@2759|Eukaryota,3A9FW@33154|Opisthokonta,3BUAQ@33208|Metazoa,3DD4V@33213|Bilateria 33208|Metazoa O Magnesium chelatase, subunit ChlI C-terminal - - - - - - - - - - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_1481304_2 877411.JMMA01000002_gene1079 2.25e-26 111.0 COG2206@1|root,COG3275@1|root,COG3292@1|root,COG2206@2|Bacteria,COG3275@2|Bacteria,COG3292@2|Bacteria,1TVUD@1239|Firmicutes,24B60@186801|Clostridia,3WRN0@541000|Ruminococcaceae 186801|Clostridia T Y_Y_Y domain - - - ko:K16923 - M00582 - - ko00000,ko00002,ko02000 3.A.1.28 - - HD,Reg_prop,Y_Y_Y k59_1635419_1 338963.Pcar_1237 2.79e-108 323.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NK7@68525|delta/epsilon subdivisions,2WKTV@28221|Deltaproteobacteria,43RYC@69541|Desulfuromonadales 28221|Deltaproteobacteria C Glu/Leu/Phe/Val dehydrogenase, dimerisation domain - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_803616_1 748247.AZKH_3780 8.7e-12 70.5 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHZQ@28216|Betaproteobacteria,2KUT5@206389|Rhodocyclales 206389|Rhodocyclales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18303 - M00642 - - ko00000,ko00002,ko01504,ko02000 2.A.6.2.17 - - ACR_tran k59_1635420_2 240015.ACP_0113 7.24e-23 104.0 COG1132@1|root,COG1132@2|Bacteria,3Y32T@57723|Acidobacteria,2JIBZ@204432|Acidobacteriia 204432|Acidobacteriia V ABC transporter, transmembrane - - - ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_487760_1 1304275.C41B8_16579 1.82e-80 258.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1055 Na H antiporter NhaD and related arsenite permeases nhaD - - - - - - - - - - - CitMHS k59_1581845_1 1460635.JCM19038_2804 1.32e-11 67.8 COG0740@1|root,COG0740@2|Bacteria,1TR2H@1239|Firmicutes,4HD7V@91061|Bacilli 91061|Bacilli OU Belongs to the peptidase S14 family - - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_589732_1 1238182.C882_3824 4.95e-43 152.0 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,2TSHM@28211|Alphaproteobacteria,2JQ9Q@204441|Rhodospirillales 204441|Rhodospirillales S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_1373341_1 314278.NB231_03320 7.41e-247 705.0 COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,1RPD2@1236|Gammaproteobacteria,1WXID@135613|Chromatiales 135613|Chromatiales S doubled CXXCH - - - - - - - - - - - - Cytochrome_C554,Paired_CXXCH_1,TPR_19,TPR_8 k59_1112450_2 1165096.ARWF01000001_gene669 1.25e-76 232.0 COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,2VQ71@28216|Betaproteobacteria,2KM1Q@206350|Nitrosomonadales 206350|Nitrosomonadales I Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length fabA - 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_1481341_1 247633.GP2143_17596 1.62e-34 131.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,1SNUJ@1236|Gammaproteobacteria,1JA38@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_1273364_1 748658.KB907313_gene2022 6.67e-31 114.0 COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,1WYI6@135613|Chromatiales 135613|Chromatiales J Belongs to the HSP15 family - - - ko:K04762 - - - - ko00000,ko03110 - - - S4 k59_1163024_1 1049564.TevJSym_ah00850 2.62e-79 262.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1J4IV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_487783_1 1493511.A0A0E3HIK0_9CAUD 1.81e-32 134.0 4QAK6@10239|Viruses 10239|Viruses S N-acetylmuramoyl-L-alanine amidase activity - - - - - - - - - - - - - k59_803658_1 405948.SACE_4885 1.02e-26 108.0 COG2141@1|root,COG2141@2|Bacteria,2GJTP@201174|Actinobacteria,4E39N@85010|Pseudonocardiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_803658_2 526225.Gobs_2778 2.05e-41 140.0 COG0662@1|root,COG0662@2|Bacteria,2GTM8@201174|Actinobacteria 201174|Actinobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 k59_1060352_1 436308.Nmar_0855 5.31e-34 117.0 arCOG08032@1|root,arCOG08032@2157|Archaea,41T69@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1060352_2 1131266.ARWQ01000002_gene527 2.18e-28 103.0 COG1522@1|root,arCOG01117@2157|Archaea,41T6U@651137|Thaumarchaeota 651137|Thaumarchaeota K Lrp/AsnC ligand binding domain - - - - - - - - - - - - AsnC_trans_reg k59_1060352_3 436308.Nmar_0853 5.41e-05 44.3 COG0346@1|root,arCOG02708@2157|Archaea,41SU3@651137|Thaumarchaeota 651137|Thaumarchaeota E Glyoxalase-like domain - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase,Glyoxalase_2 k59_1319552_1 864051.BurJ1DRAFT_3787 1.13e-32 128.0 COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,2WHEI@28216|Betaproteobacteria,1KK66@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_1581857_1 557599.MKAN_07650 6.71e-268 741.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,234H1@1762|Mycobacteriaceae 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1581857_2 1299327.I546_2826 1.6e-47 164.0 COG2124@1|root,COG2124@2|Bacteria,2GKKN@201174|Actinobacteria,23477@1762|Mycobacteriaceae 201174|Actinobacteria Q cytochrome p450 - - 1.14.15.13 ko:K17474 - - - - ko00000,ko00199,ko01000 - - - p450 k59_537319_1 448385.sce3129 1.51e-49 178.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2WIQ7@28221|Deltaproteobacteria,2YTZJ@29|Myxococcales 28221|Deltaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1319557_1 187944.H8YJ73_9CAUD 3.21e-45 157.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKP8@10699|Siphoviridae 10699|Siphoviridae S peptidase activity - GO:0005575,GO:0019012,GO:0019028,GO:0032991,GO:0044423,GO:0046806 - - - - - - - - - - - k59_746334_1 1075090.GOAMR_11_00220 8.84e-25 103.0 COG2124@1|root,COG2124@2|Bacteria,2GJ3T@201174|Actinobacteria,4GGYZ@85026|Gordoniaceae 201174|Actinobacteria C Cytochrome P450 cyp189A7 - - - - - - - - - - - p450 k59_746334_2 1056816.JAFQ01000004_gene3433 2.39e-14 71.2 COG1335@1|root,COG1335@2|Bacteria,2I81Y@201174|Actinobacteria,4G09A@85025|Nocardiaceae 201174|Actinobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_276751_1 1049564.TevJSym_bh00300 8.76e-107 320.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1J4ZF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009314,GO:0009628,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_382308_1 981369.JQMJ01000004_gene5860 3.19e-30 118.0 COG0179@1|root,COG0179@2|Bacteria,2GKED@201174|Actinobacteria,2NFSZ@228398|Streptacidiphilus 201174|Actinobacteria Q Fumarylacetoacetate (FAA) hydrolase family - - - - - - - - - - - - FAA_hydrolase k59_1319561_1 740709.A10D4_00410 7.81e-89 272.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,2QFG6@267893|Idiomarinaceae 1236|Gammaproteobacteria F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475 TGT k59_382312_1 316067.Geob_3803 2.91e-53 174.0 COG2716@1|root,COG2716@2|Bacteria,1RB6J@1224|Proteobacteria,42RTX@68525|delta/epsilon subdivisions,2WPGC@28221|Deltaproteobacteria,43UTV@69541|Desulfuromonadales 28221|Deltaproteobacteria E PFAM amino acid-binding ACT domain protein - - - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT_6 k59_71945_1 857087.Metme_1074 5.31e-111 340.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1XEMN@135618|Methylococcales 135618|Methylococcales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_382314_1 266834.SMc00329 1.61e-18 80.5 COG0735@1|root,COG0735@2|Bacteria,1RH58@1224|Proteobacteria,2U75R@28211|Alphaproteobacteria,4BDYU@82115|Rhizobiaceae 28211|Alphaproteobacteria K Belongs to the Fur family irr - - ko:K09826 - - - - ko00000,ko03000 - - - FUR k59_803688_1 471854.Dfer_0332 8.83e-26 107.0 COG3119@1|root,COG3119@2|Bacteria,4PKKW@976|Bacteroidetes,47KTM@768503|Cytophagia 976|Bacteroidetes P Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_433232_1 1177181.T9A_01303 2.97e-14 70.9 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria,1XKC3@135619|Oceanospirillales 135619|Oceanospirillales D COG1192 ATPases involved in chromosome partitioning - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_433232_2 290398.Csal_3113 9.15e-41 144.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,1XHA1@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_7131_2 316274.Haur_3244 4.96e-21 89.0 COG1607@1|root,COG1607@2|Bacteria,2GB6B@200795|Chloroflexi,377FE@32061|Chloroflexia 32061|Chloroflexia I PFAM thioesterase superfamily protein - - - - - - - - - - - - 4HBT k59_1481398_1 47763.JNZA01000023_gene2931 2.34e-70 233.0 COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria 201174|Actinobacteria E amidohydrolase - - - - - - - - - - - - Amidohydro_3 k59_803698_1 1299327.I546_2833 7.5e-34 131.0 COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,235W7@1762|Mycobacteriaceae 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_329376_1 59196.RICGR_1367 1.13e-65 221.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1JD0N@118969|Legionellales 118969|Legionellales J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_1373390_1 1077972.ARGLB_011_00250 2.4e-121 373.0 COG2303@1|root,COG2303@2|Bacteria,2I5YA@201174|Actinobacteria 201174|Actinobacteria E oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_803705_1 44251.PDUR_00290 2.99e-19 84.0 COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,4HFZ2@91061|Bacilli,26SCN@186822|Paenibacillaceae 91061|Bacilli F Belongs to the purine pyrimidine phosphoribosyltransferase family hpt GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8,6.3.4.19 ko:K00760,ko:K15780 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000,ko03016 - - - Pribosyltran k59_803705_2 926569.ANT_18270 6.38e-19 80.9 COG1102@1|root,COG1102@2|Bacteria 2|Bacteria F Psort location Cytoplasmic, score - - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Cytidylate_kin2,GAF_2,Pribosyltran k59_696252_1 1380391.JIAS01000012_gene4217 5.03e-16 78.6 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2U1EJ@28211|Alphaproteobacteria,2JRHV@204441|Rhodospirillales 204441|Rhodospirillales U AAA domain - - - - - - - - - - - - AAA_22 k59_1427756_1 568706.BN118_0493 4.32e-58 191.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2VHWQ@28216|Betaproteobacteria,3T1X4@506|Alcaligenaceae 28216|Betaproteobacteria H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_537353_1 1038859.AXAU01000001_gene3656 1.64e-18 81.3 COG3474@1|root,COG3474@2|Bacteria,1R7NI@1224|Proteobacteria,2U1TH@28211|Alphaproteobacteria,3JVJQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C cytochrome - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_1529228_1 234267.Acid_7408 5.16e-10 67.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K10941 ko02020,ko02025,ko05111,map02020,map02025,map05111 - - - ko00000,ko00001,ko03000 - - - FHA,HTH_8,Sigma54_activat,Yop-YscD_cpl k59_1118125_1 555779.Dthio_PD3543 2.72e-74 242.0 COG2251@1|root,COG2251@2|Bacteria,1QUUG@1224|Proteobacteria,43CSJ@68525|delta/epsilon subdivisions,2X807@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Domain of unknown function(DUF2779) - - - - - - - - - - - - DUF2779 k59_960467_1 436308.Nmar_1581 2.64e-62 197.0 COG2266@1|root,arCOG01871@2157|Archaea,41SRI@651137|Thaumarchaeota 651137|Thaumarchaeota M MobA-like NTP transferase domain - - 2.7.7.62 ko:K19712 ko00860,ko01100,map00860,map01100 - R05222 RC00002 ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_335082_1 290397.Adeh_0051 2.46e-86 262.0 COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,42MZB@68525|delta/epsilon subdivisions,2WKV4@28221|Deltaproteobacteria,2YUTH@29|Myxococcales 28221|Deltaproteobacteria P Membrane protein, TerC - - - - - - - - - - - - TerC k59_909471_1 768671.ThimaDRAFT_3959 1.61e-130 400.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1WWWU@135613|Chromatiales 135613|Chromatiales C CoA-binding domain protein - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_811532_1 339670.Bamb_5433 2.12e-57 190.0 COG0330@1|root,COG0330@2|Bacteria,1MWMD@1224|Proteobacteria,2VKGC@28216|Betaproteobacteria,1KCFD@119060|Burkholderiaceae 28216|Betaproteobacteria O prohibitin homologues - - - - - - - - - - - - Band_7 k59_1167454_1 717772.THIAE_05435 8.16e-09 56.2 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,46068@72273|Thiotrichales 72273|Thiotrichales G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_1167454_2 857087.Metme_3410 2.26e-17 77.0 COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,1XFRY@135618|Methylococcales 135618|Methylococcales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsB - - ko:K05589 - - - - ko00000,ko03036 - - - DivIC k59_654423_1 1041159.AZUW01000001_gene3417 2.75e-22 100.0 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,2TUBP@28211|Alphaproteobacteria,4B77J@82115|Rhizobiaceae 28211|Alphaproteobacteria S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_439815_1 1493511.A0A0E3HP61_9CAUD 1.8e-23 105.0 4QDP2@10239|Viruses,4QT1E@28883|Caudovirales,4QI5J@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1642167_1 911045.PSE_3716 1.09e-12 75.1 COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2U1YP@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - He_PIG,HemolysinCabind,VWA_2 k59_542882_1 66377.JOBH01000006_gene238 9.6e-18 83.6 COG1309@1|root,COG1309@2|Bacteria,2GWAE@201174|Actinobacteria 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1323836_2 573370.DMR_11610 4.04e-28 105.0 COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42V9Q@68525|delta/epsilon subdivisions,2WRRT@28221|Deltaproteobacteria,2MCID@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM RNP-1 like RNA-binding protein - - - - - - - - - - - - RRM_1 k59_79796_1 349124.Hhal_0675 1.53e-84 259.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria,1WWMY@135613|Chromatiales 135613|Chromatiales H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_229887_1 330214.NIDE3293 1.41e-79 254.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,DHOR,DUF3365,FixO,PSCyt1 k59_752178_1 1469245.JFBG01000001_gene489 8.88e-118 355.0 COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,1RZ0U@1236|Gammaproteobacteria,1WW7B@135613|Chromatiales 135613|Chromatiales C reductase, alpha subunit - - 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2 k59_439839_1 314230.DSM3645_28962 9.06e-72 233.0 COG0591@1|root,COG0591@2|Bacteria,2J22E@203682|Planctomycetes 203682|Planctomycetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_439839_2 502025.Hoch_4956 4.81e-25 101.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2WIZZ@28221|Deltaproteobacteria,2YU7R@29|Myxococcales 28221|Deltaproteobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_495676_1 926569.ANT_29450 1.26e-29 118.0 COG0583@1|root,COG0583@2|Bacteria,2G70X@200795|Chloroflexi 200795|Chloroflexi K regulatory protein LysR - - - ko:K21703 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_335108_1 1123366.TH3_06440 1.27e-43 145.0 2C07J@1|root,32SWS@2|Bacteria,1N0NW@1224|Proteobacteria,2UCVR@28211|Alphaproteobacteria,2JTB5@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_335108_2 1110502.TMO_2046 1e-127 367.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,2JPVM@204441|Rhodospirillales 204441|Rhodospirillales E branched-chain amino acid - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_335108_3 1207063.P24_18541 8.27e-147 420.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,2JP9T@204441|Rhodospirillales 204441|Rhodospirillales E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_1066265_1 765913.ThidrDRAFT_1424 1.22e-92 280.0 28I2K@1|root,2Z86N@2|Bacteria,1R1GA@1224|Proteobacteria,1RRPU@1236|Gammaproteobacteria,1WXHU@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_1066265_2 377629.TERTU_0824 2.72e-54 186.0 COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,1S01Y@1236|Gammaproteobacteria,2PNKP@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria T PAS fold - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_960509_1 1254432.SCE1572_52115 1.04e-43 150.0 COG5031@1|root,COG5031@2|Bacteria,1NKS8@1224|Proteobacteria,434J5@68525|delta/epsilon subdivisions,2WYWC@28221|Deltaproteobacteria,2Z0SR@29|Myxococcales 28221|Deltaproteobacteria H ubiquinone biosynthetic process - - - - - - - - - - - - - k59_1281542_1 1423775.BAMN01000024_gene2847 5.36e-36 134.0 COG1131@1|root,COG1131@2|Bacteria,1TPJE@1239|Firmicutes,4HB5U@91061|Bacilli,3F58G@33958|Lactobacillaceae 91061|Bacilli V ABC transporter drrA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_909519_1 926554.KI912633_gene3852 3.21e-10 61.2 COG4251@1|root,COG4251@2|Bacteria 2|Bacteria T photoreceptor activity - - - - - - - - - - - - DUF4118,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_909519_2 1536769.P40081_26655 0.000883 43.5 COG0642@1|root,COG2205@2|Bacteria,1UEIC@1239|Firmicutes,4HDD8@91061|Bacilli,26RKT@186822|Paenibacillaceae 91061|Bacilli T Histidine kinase - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CHASE3,GAF_2,HATPase_c,HisKA,Response_reg k59_909519_3 314230.DSM3645_17730 8.41e-06 47.8 COG2204@1|root,COG2204@2|Bacteria,2IXMN@203682|Planctomycetes 203682|Planctomycetes T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1281545_1 1229909.NSED_07770 3.81e-125 365.0 COG2237@1|root,arCOG04151@2157|Archaea,41SA3@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF373) - - - ko:K08975 - - - - ko00000 - - - DUF373 k59_174543_1 290397.Adeh_0203 3.01e-36 138.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,42NA6@68525|delta/epsilon subdivisions,2WIMU@28221|Deltaproteobacteria,2YU9T@29|Myxococcales 28221|Deltaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_174543_2 240016.ABIZ01000001_gene3213 1.41e-31 120.0 COG0332@1|root,COG0332@2|Bacteria,46SE2@74201|Verrucomicrobia,2ITMR@203494|Verrucomicrobiae 203494|Verrucomicrobiae I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_960523_1 264462.Bd0967 9.87e-37 143.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42NID@68525|delta/epsilon subdivisions,2MSNJ@213481|Bdellovibrionales,2WJ4P@28221|Deltaproteobacteria 213481|Bdellovibrionales M Belongs to the peptidase S41A family prc - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - DUF3340,PDZ,Peptidase_S41 k59_752205_1 1035197.HMPREF9999_01329 2.06e-06 53.5 COG1007@1|root,COG1007@2|Bacteria,4NF94@976|Bacteroidetes,2FNTS@200643|Bacteroidia,1WD6R@1283313|Alloprevotella 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_752205_2 1379698.RBG1_1C00001G0030 5.49e-95 293.0 COG1008@1|root,COG1008@2|Bacteria,2NQKN@2323|unclassified Bacteria 2|Bacteria C Proton-conducting membrane transporter ndhD - 1.6.5.3 ko:K00342,ko:K05575 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iJN678.ndhD2 Oxidored_q5_N,Proton_antipo_M k59_229920_2 436308.Nmar_1724 3e-77 239.0 COG0006@1|root,arCOG01000@2157|Archaea,41T14@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the peptidase M24B family - - 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_495716_1 926566.Terro_1269 2.05e-06 52.0 COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y2Q2@57723|Acidobacteria 57723|Acidobacteria KU WD40-like Beta Propeller - - - - - - - - - - - - PD40,Trans_reg_C k59_1013439_1 1121861.KB899924_gene3520 2.31e-25 104.0 COG1556@1|root,COG1556@2|Bacteria,1R4TE@1224|Proteobacteria,2U5II@28211|Alphaproteobacteria,2JS58@204441|Rhodospirillales 204441|Rhodospirillales S LUD domain - - - ko:K00782 - - - - ko00000 - - - LUD_dom k59_1013439_2 1469245.JFBG01000040_gene1739 1.37e-95 293.0 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,1RQEA@1236|Gammaproteobacteria,1WXT5@135613|Chromatiales 135613|Chromatiales C LUD domain - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_1435442_1 983545.Glaag_0743 2.46e-43 160.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,46425@72275|Alteromonadaceae 1236|Gammaproteobacteria V Efflux pump mexF2 - - ko:K18138,ko:K18299 ko01501,ko01503,map01501,map01503 M00641,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.16 - - ACR_tran k59_495717_1 1121405.dsmv_3742 1.14e-46 157.0 COG0270@1|root,COG0270@2|Bacteria,1NE40@1224|Proteobacteria,42WBI@68525|delta/epsilon subdivisions,2WSDV@28221|Deltaproteobacteria,2MM55@213118|Desulfobacterales 28221|Deltaproteobacteria L DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - - k59_495717_2 1121405.dsmv_3741 3.03e-50 168.0 COG2801@1|root,COG2801@2|Bacteria,1RCQN@1224|Proteobacteria,42R94@68525|delta/epsilon subdivisions,2WN3K@28221|Deltaproteobacteria,2MJKF@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - - k59_752216_1 754476.Q7A_1023 8.49e-112 329.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,460HI@72273|Thiotrichales 72273|Thiotrichales M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_282756_1 883080.HMPREF9697_03007 4.1e-64 216.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TU0K@28211|Alphaproteobacteria,3JUIP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain merA - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_1013451_1 1453496.AT03_11115 1.8e-39 148.0 COG0715@1|root,COG2204@1|root,COG0715@2|Bacteria,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains flbD - - - - - - - - - - - HTH_8,NMT1,Sigma54_activat k59_1587975_1 911045.PSE_4152 4.61e-32 121.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_1587975_2 1380391.JIAS01000014_gene2229 2.4e-11 64.3 COG1167@1|root,COG1167@2|Bacteria,1MVGT@1224|Proteobacteria,2TRK7@28211|Alphaproteobacteria,2JQYG@204441|Rhodospirillales 204441|Rhodospirillales K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - ko:K00375 - - - - ko00000,ko03000 - - - Aminotran_1_2,GntR k59_229941_1 2340.JV46_14270 6.11e-34 125.0 COG1394@1|root,COG1394@2|Bacteria,1RJ1P@1224|Proteobacteria,1S75D@1236|Gammaproteobacteria 1236|Gammaproteobacteria C ATP synthase subunit D - - - ko:K02120 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_D k59_127115_1 994479.GL877881_gene6290 6.98e-74 236.0 COG1960@1|root,COG1960@2|Bacteria,2GITF@201174|Actinobacteria,4DXR7@85010|Pseudonocardiales 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_389441_1 1123371.ATXH01000014_gene1585 1.9e-16 84.7 COG1033@1|root,COG1033@2|Bacteria,2GIBA@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Patched family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_542955_1 1122135.KB893134_gene3130 1.45e-130 385.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2TU8Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3,CTP_transf_3 k59_752243_1 1469245.JFBG01000035_gene1999 5.55e-41 151.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1WW4R@135613|Chromatiales 135613|Chromatiales D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves - - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_174577_1 357804.Ping_0287 9.93e-08 54.7 COG0287@1|root,COG1605@1|root,COG0287@2|Bacteria,COG1605@2|Bacteria,1MVUT@1224|Proteobacteria,1RQB3@1236|Gammaproteobacteria,2QH7E@267894|Psychromonadaceae 1236|Gammaproteobacteria E Chorismate mutase type II tyrA GO:0000166,GO:0003674,GO:0003824,GO:0004106,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 1.3.1.12,5.4.99.5 ko:K04517,ko:K14187 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00024,M00025 R01715,R01728 RC00125,RC03116 ko00000,ko00001,ko00002,ko01000 - - iECUMN_1333.ECUMN_2925 ACT,CM_2,PDH k59_752245_2 660470.Theba_1316 3.03e-22 101.0 COG0060@1|root,COG0060@2|Bacteria,2GC5I@200918|Thermotogae 200918|Thermotogae J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_1118237_1 1000565.METUNv1_01501 6.73e-169 483.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,2KUBF@206389|Rhodocyclales 206389|Rhodocyclales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_702151_1 436308.Nmar_0674 9.13e-09 55.8 COG0589@1|root,arCOG02053@2157|Archaea,41TB2@651137|Thaumarchaeota 651137|Thaumarchaeota T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp k59_702151_2 491952.Mar181_2999 2.62e-05 48.5 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1XNJU@135619|Oceanospirillales 135619|Oceanospirillales T Putative nucleotidyltransferase substrate binding domain - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_857212_1 265072.Mfla_0037 1.31e-48 168.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2VH9S@28216|Betaproteobacteria,2KM4E@206350|Nitrosomonadales 206350|Nitrosomonadales T PFAM histidine kinase - - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase k59_857212_2 1415780.JPOG01000001_gene2268 1.36e-10 61.2 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,1X3HP@135614|Xanthomonadales 135614|Xanthomonadales KT Response regulator of the LytR AlgR family - - - ko:K08083 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_1323914_1 717231.Flexsi_2343 1.41e-76 247.0 COG0443@1|root,COG0443@2|Bacteria,2GEXS@200930|Deferribacteres 200930|Deferribacteres O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_282783_1 1380394.JADL01000006_gene5313 1.06e-150 452.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQY7@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_282783_2 768671.ThimaDRAFT_0808 1.34e-214 606.0 COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1WXN7@135613|Chromatiales 135613|Chromatiales P Chromate transporter - - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_909590_1 589865.DaAHT2_1435 0.000782 41.6 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,2MHKK@213118|Desulfobacterales 28221|Deltaproteobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_909590_2 309799.DICTH_0853 1.94e-33 120.0 COG0256@1|root,COG0256@2|Bacteria 2|Bacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_909590_3 547144.HydHO_0279 2.63e-05 45.1 COG0097@1|root,COG0097@2|Bacteria,2G3Z5@200783|Aquificae 200783|Aquificae J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_1226991_1 298655.KI912266_gene6134 4.76e-102 303.0 COG1028@1|root,COG1028@2|Bacteria,2GK47@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr ydaD - - - - - - - - - - - adh_short_C2 k59_128031_1 118168.MC7420_845 7.65e-06 53.5 COG2203@1|root,COG2203@2|Bacteria,1G39J@1117|Cyanobacteria,1H8S2@1150|Oscillatoriales 2|Bacteria T Gaf domain - - - - - - - - - - - - GAF k59_596437_1 436308.Nmar_1573 1.35e-107 323.0 COG0519@1|root,arCOG00085@2157|Archaea,41SDI@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_1324454_2 247634.GPB2148_1155 5.51e-38 143.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,1J5AG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1282547_1 1131266.ARWQ01000006_gene283 2.38e-22 89.4 arCOG10531@1|root,arCOG10531@2157|Archaea,41T4F@651137|Thaumarchaeota 651137|Thaumarchaeota S zinc finger - - - - - - - - - - - - - k59_136247_2 331869.BAL199_09860 2.26e-21 94.4 COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,2TQMC@28211|Alphaproteobacteria,4BRH0@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S PrpF protein - - - ko:K09788 ko00640,map00640 - R11264 RC03405 ko00000,ko00001,ko01000 - - - PrpF k59_821797_1 1121904.ARBP01000012_gene1248 4.31e-58 195.0 COG5000@1|root,COG5000@2|Bacteria,4NEWF@976|Bacteroidetes,47JZG@768503|Cytophagia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c k59_449125_1 392499.Swit_1765 1.24e-30 119.0 COG2159@1|root,COG2159@2|Bacteria,1Q4XY@1224|Proteobacteria,2U25S@28211|Alphaproteobacteria,2K8E7@204457|Sphingomonadales 204457|Sphingomonadales S Amidohydrolase - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_449125_2 266265.Bxe_C1047 5.76e-22 95.9 COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,2VVNG@28216|Betaproteobacteria,1K21M@119060|Burkholderiaceae 28216|Betaproteobacteria I Alpha beta hydrolase - - 3.1.1.83 ko:K14731 ko00903,ko00930,ko01220,map00903,map00930,map01220 - R03751,R06390,R06391,R06392,R06393 RC00713,RC00983,RC01505 ko00000,ko00001,ko01000 - - - Abhydrolase_3 k59_343416_1 1485544.JQKP01000002_gene1453 4.85e-50 181.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,44V3Z@713636|Nitrosomonadales 28216|Betaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_1499267_2 268746.Q58MM1_BPPRM 1.82e-107 313.0 4QAWI@10239|Viruses,4QW40@35237|dsDNA viruses no RNA stage,4QPUX@28883|Caudovirales,4QINW@10662|Myoviridae 10662|Myoviridae S Pfam:Peptidase_S77 - - - - - - - - - - - - - k59_602965_1 857087.Metme_0886 1.48e-86 266.0 COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,1RM7T@1236|Gammaproteobacteria,1XE2G@135618|Methylococcales 135618|Methylococcales E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metAS GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0008899,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - HTS k59_968093_1 1255043.TVNIR_0680 3.38e-115 341.0 COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,1RMIY@1236|Gammaproteobacteria,1WWR3@135613|Chromatiales 135613|Chromatiales M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_1499270_2 1298593.TOL_0598 4.54e-52 174.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1XIZA@135619|Oceanospirillales 135619|Oceanospirillales J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_1291764_1 436308.Nmar_0642 2.49e-62 201.0 COG0389@1|root,arCOG04582@2157|Archaea,41SDV@651137|Thaumarchaeota 651137|Thaumarchaeota L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis dbh - 2.7.7.7 ko:K04479 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_1291764_2 1459636.NTE_01651 4.18e-17 74.7 arCOG08668@1|root,arCOG08668@2157|Archaea,41SW4@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_13744_1 1089553.Tph_c25850 6.43e-41 142.0 COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,247NH@186801|Clostridia,42FAS@68295|Thermoanaerobacterales 186801|Clostridia J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_1174008_1 930166.CD58_05680 1.36e-123 362.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria 1236|Gammaproteobacteria D recombinase XerD xerD GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_136281_1 330214.NIDE0827 1.49e-56 188.0 COG0674@1|root,COG0674@2|Bacteria,3J105@40117|Nitrospirae 40117|Nitrospirae C Pyruvate:ferredoxin oxidoreductase core domain II - - 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_136281_2 330214.NIDE0826 3.87e-34 123.0 COG0226@1|root,COG0226@2|Bacteria,3J0YH@40117|Nitrospirae 2|Bacteria P Evidence 2a Function of homologous gene experimentally demonstrated in an other organism forD - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - CO_dh,PBP_like_2 k59_1652521_1 330214.NIDE0346 7.31e-31 118.0 COG3016@1|root,COG3016@2|Bacteria 2|Bacteria S Haem-binding uptake, Tiki superfamily, ChaN phuW - - - - - - - - - - - Cofac_haem_bdg,PDZ_2 k59_1652521_2 330214.NIDE0347 8.68e-17 79.0 COG4715@1|root,COG4715@2|Bacteria 2|Bacteria S zinc ion binding yehQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - SWIM k59_1595234_1 672.VV93_v1c24400 7.18e-50 180.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XU61@135623|Vibrionales 135623|Vibrionales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18989 - M00720 - - ko00000,ko00002,ko02000 2.A.6.2.30 - - ACR_tran k59_237391_2 111780.Sta7437_1517 5.95e-34 131.0 COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,1G0BS@1117|Cyanobacteria,3VHU5@52604|Pleurocapsales 1117|Cyanobacteria T Diguanylate cyclase (GGDEF domain) - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1074713_1 1027292.HMPREF9372_0021 2e-06 52.4 COG1595@1|root,COG1595@2|Bacteria,1V9ZH@1239|Firmicutes,4HFFV@91061|Bacilli,26GNQ@186818|Planococcaceae 91061|Bacilli K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_13752_1 1173028.ANKO01000129_gene1980 2.43e-10 65.9 COG1232@1|root,COG3349@1|root,COG1232@2|Bacteria,COG3349@2|Bacteria,1G24U@1117|Cyanobacteria,1H8PT@1150|Oscillatoriales 1117|Cyanobacteria H PFAM Flavin containing amine oxidoreductase crtU - - ko:K09879 ko00906,map00906 - R07541,R07560,R07857,R07858 RC01901,RC01965 ko00000,ko00001 - - - Amino_oxidase,Rieske k59_550349_1 697281.Mahau_2215 6.11e-13 72.0 COG3225@1|root,COG3225@2|Bacteria,1TT1J@1239|Firmicutes,24BC2@186801|Clostridia,42FP0@68295|Thermoanaerobacterales 186801|Clostridia P PFAM ABC-type uncharacterised transport system - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3,ABC_transp_aux k59_602988_1 530564.Psta_2406 1.95e-133 395.0 COG0172@1|root,COG0172@2|Bacteria,2IXGP@203682|Planctomycetes 203682|Planctomycetes J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_602988_2 225849.swp_1307 4.12e-24 98.6 COG4221@1|root,COG4221@2|Bacteria,1PWXN@1224|Proteobacteria,1S226@1236|Gammaproteobacteria,2QBUK@267890|Shewanellaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4336) - - - - - - - - - - - - DUF4336 k59_1499318_1 641491.DND132_3420 1.11e-37 138.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria,2M8YH@213115|Desulfovibrionales 28221|Deltaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_1499318_2 652103.Rpdx1_2204 3.21e-48 166.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2TT6A@28211|Alphaproteobacteria,3JRQB@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_1385747_1 1415780.JPOG01000001_gene2851 1.73e-56 184.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1X4GY@135614|Xanthomonadales 135614|Xanthomonadales H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_1385756_1 266762.HQ36_02060 3.66e-06 53.1 COG0553@1|root,COG0553@2|Bacteria,4PJBJ@976|Bacteroidetes,2FRBF@200643|Bacteroidia 976|Bacteroidetes KL SNF2 family N-terminal domain - - - - - - - - - - - - SNF2_N k59_759550_1 1305737.JAFX01000001_gene839 5.58e-50 180.0 COG0188@1|root,COG0188@2|Bacteria,4NDWQ@976|Bacteroidetes,47K30@768503|Cytophagia 976|Bacteroidetes L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_821880_2 1229909.NSED_00025 1.93e-47 162.0 COG1467@1|root,arCOG04110@2157|Archaea,41SCB@651137|Thaumarchaeota 651137|Thaumarchaeota L Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair priS - - ko:K02683 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DNA_primase_S k59_1499348_1 436308.Nmar_1379 6.81e-06 47.0 COG0473@1|root,arCOG01163@2157|Archaea,41S5U@651137|Thaumarchaeota 651137|Thaumarchaeota C Isocitrate isopropylmalate dehydrogenase - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_1499348_2 1229909.NSED_07505 2.33e-64 202.0 COG1409@1|root,arCOG01153@2157|Archaea,41SF2@651137|Thaumarchaeota 651137|Thaumarchaeota S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos k59_180852_1 1229909.NSED_02165 8.87e-24 94.7 arCOG08663@1|root,arCOG08663@2157|Archaea,41SR2@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_180852_2 436308.Nmar_0417 1.29e-58 182.0 arCOG10524@1|root,arCOG10524@2157|Archaea,41SVP@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_759564_1 234267.Acid_2464 7.23e-11 66.2 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria 57723|Acidobacteria KLTU WD40 domain protein beta Propeller - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase k59_1291856_1 929556.Solca_0522 1.4e-25 105.0 COG1032@1|root,COG1032@2|Bacteria,4PHMM@976|Bacteroidetes,1IWI2@117747|Sphingobacteriia 976|Bacteroidetes C radical SAM domain protein - - - - - - - - - - - - - k59_1235553_1 472759.Nhal_3716 4.12e-94 288.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1WWJH@135613|Chromatiales 135613|Chromatiales E peptidase M24B, X-Pro dipeptidase aminopeptidase - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_1595281_1 1469245.JFBG01000006_gene1580 2.55e-75 235.0 COG2141@1|root,COG2141@2|Bacteria,1R9CH@1224|Proteobacteria,1RZ9F@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_864640_1 644966.Tmar_1103 9.99e-08 53.1 COG0476@1|root,COG0607@1|root,COG1977@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,COG1977@2|Bacteria,1TQ3U@1239|Firmicutes,25CJC@186801|Clostridia,3WDCG@538999|Clostridiales incertae sedis 186801|Clostridia H ThiF family - - 2.7.7.80,2.8.1.11 ko:K21029,ko:K21147 ko04122,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - Rhodanese,ThiF,ThiS k59_344640_1 743721.Psesu_1779 1.58e-43 155.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1X3ED@135614|Xanthomonadales 135614|Xanthomonadales C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_344640_2 1265507.KB899636_gene1918 3.43e-12 65.9 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1Y44P@135624|Aeromonadales 135624|Aeromonadales F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_1075967_1 445970.ALIPUT_01953 2.72e-05 51.6 COG1404@1|root,COG1404@2|Bacteria,4NF1M@976|Bacteroidetes,2FPU1@200643|Bacteroidia 976|Bacteroidetes O Peptidase, S8 S53 family - - - - - - - - - - - - Peptidase_S8,Peptidase_S8_N,fn3 k59_865453_1 1286171.EAL2_c15800 9.65e-88 278.0 COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,25V4A@186806|Eubacteriaceae 186801|Clostridia G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_969042_1 1469245.JFBG01000010_gene599 1.39e-243 695.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,1X2PM@135613|Chromatiales 135613|Chromatiales C TIGRFAM formate dehydrogenase, alpha subunit - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_396623_1 870967.VIS19158_12538 1.32e-90 277.0 COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,1XTCQ@135623|Vibrionales 135623|Vibrionales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway nqrF GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0048037,GO:0050136,GO:0050660,GO:0050662,GO:0051179,GO:0051234,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071949,GO:0097159,GO:0098796,GO:1901265,GO:1901363,GO:1902494 1.6.5.8 ko:K00351 - - - - ko00000,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_1128163_2 981336.F944_01592 1.31e-48 178.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,3NJFY@468|Moraxellaceae 1236|Gammaproteobacteria M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) mrcB GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008289,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042277,GO:0042546,GO:0042597,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071723,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iECIAI39_1322.ECIAI39_0153,iSBO_1134.SBO_0138,iSbBS512_1146.SbBS512_E0140,iYL1228.KPN_00164 PBP1_TM,Transgly,Transpeptidase,UB2H k59_396627_1 1005395.CSV86_06956 1.31e-50 173.0 COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,1RS3S@1236|Gammaproteobacteria,1YWRP@136845|Pseudomonas putida group 1236|Gammaproteobacteria HL Nudix hydrolase mutT GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008413,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017110,GO:0030145,GO:0033554,GO:0034641,GO:0035539,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044715,GO:0044716,GO:0046483,GO:0046872,GO:0046914,GO:0047429,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - iE2348C_1286.E2348C_0104,iSDY_1059.SDY_0129 NUDIX,NUDIX_4,TMP-TENI k59_710432_2 931277.C448_12276 6.84e-36 127.0 COG1545@1|root,arCOG01285@2157|Archaea,2XXG8@28890|Euryarchaeota,23VS7@183963|Halobacteria 183963|Halobacteria V nucleic-acid-binding protein containing a Zn-ribbon - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_710432_3 298655.KI912266_gene4040 4.18e-14 71.6 COG0183@1|root,COG0183@2|Bacteria,2GKFR@201174|Actinobacteria,4EVDY@85013|Frankiales 201174|Actinobacteria I lipid-transfer protein - - - - - - - - - - - - - k59_760383_1 99598.Cal7507_0195 7.74e-60 192.0 COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria,1HM2J@1161|Nostocales 1117|Cyanobacteria S Belongs to the SOS response-associated peptidase family - - - - - - - - - - - - SRAP k59_551287_1 113395.AXAI01000002_gene5219 5.04e-12 72.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1 k59_14196_1 95619.PM1_0224005 5.11e-09 58.9 COG0583@1|root,COG0583@2|Bacteria,1RGZ4@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_1128173_1 518766.Rmar_0923 8.81e-69 234.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes,1FIM5@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes EI ArgK protein icmF - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_1500572_1 1049564.TevJSym_aj00440 4.95e-28 117.0 COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,1J4Z4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M lipoprotein lpoA GO:0000270,GO:0003674,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - ko:K07121 - - - - ko00000 - - - LppC k59_14197_1 1123258.AQXZ01000019_gene2935 3.64e-32 126.0 COG0477@1|root,COG2814@2|Bacteria,2GJF6@201174|Actinobacteria,4FW4B@85025|Nocardiaceae 201174|Actinobacteria EGP Sugar (and other) transporter - - - ko:K08369 - - - - ko00000,ko02000 2.A.1 - - MFS_1,MFS_4,Sugar_tr k59_551292_2 1242864.D187_006569 2.08e-87 265.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,42MAM@68525|delta/epsilon subdivisions,2WK4Y@28221|Deltaproteobacteria,2YV0E@29|Myxococcales 28221|Deltaproteobacteria D ABC transporter ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_603804_1 1218075.BAYA01000034_gene6194 2.35e-10 62.8 COG1960@1|root,COG1960@2|Bacteria,1P4V3@1224|Proteobacteria,2VNIA@28216|Betaproteobacteria,1K4UI@119060|Burkholderiaceae 28216|Betaproteobacteria I Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_603804_2 1227457.C451_18893 9.49e-50 172.0 COG1960@1|root,arCOG01707@2157|Archaea 2157|Archaea I COG1960 Acyl-CoA dehydrogenases - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_865493_1 1122134.KB893651_gene2342 4.1e-54 182.0 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,1XHD6@135619|Oceanospirillales 135619|Oceanospirillales K in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon cysB - - ko:K13634 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1500608_1 879212.DespoDRAFT_02049 1.53e-59 204.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2WIPR@28221|Deltaproteobacteria,2MI69@213118|Desulfobacterales 28221|Deltaproteobacteria D DNA segregation ATPase, FtsK SpoIIIE family ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1293083_1 344747.PM8797T_03489 3.5e-30 117.0 COG0535@1|root,COG0535@2|Bacteria,2IXC0@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function (DUF3641) - - - - - - - - - - - - DUF3641,Radical_SAM k59_1293083_2 1121957.ATVL01000007_gene1663 5.21e-17 81.3 COG3222@1|root,COG3222@2|Bacteria,4NM7F@976|Bacteroidetes,47PF2@768503|Cytophagia 976|Bacteroidetes S protein conserved in bacteria - - - ko:K09931 - - - - ko00000 - - - DUF2064 k59_1536522_2 344747.PM8797T_27954 1.15e-130 399.0 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,PRiA4_ORF3,zf-IS66 k59_1076039_1 1173263.Syn7502_03337 5.34e-90 280.0 COG0277@1|root,COG0277@2|Bacteria,1G1U2@1117|Cyanobacteria,1GZG1@1129|Synechococcus 1117|Cyanobacteria C Glycolate oxidase subunit GlcD glcD - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_871660_1 413404.Rmag_0117 4.95e-32 120.0 COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,1J6D7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G HAD-hyrolase-like gph GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0031404,GO:0033554,GO:0034641,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_3372,iSbBS512_1146.SbBS512_E3762,iYL1228.KPN_03756 HAD_2 k59_871660_2 1122603.ATVI01000001_gene1864 7.15e-54 175.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,1X3J3@135614|Xanthomonadales 135614|Xanthomonadales G Belongs to the ribulose-phosphate 3-epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_245097_1 436308.Nmar_1708 2.51e-33 117.0 COG0071@1|root,arCOG01832@2157|Archaea,41T74@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the small heat shock protein (HSP20) family - - - - - - - - - - - - HSP20 k59_245097_2 436308.Nmar_1707 1.24e-76 231.0 COG0125@1|root,arCOG01891@2157|Archaea,41T33@651137|Thaumarchaeota 651137|Thaumarchaeota F thymidylate kinase tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_457480_2 710685.MycrhN_5191 5.28e-16 81.3 COG0183@1|root,COG0183@2|Bacteria,2ICRC@201174|Actinobacteria,236IM@1762|Mycobacteriaceae 201174|Actinobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - - k59_1028077_1 62928.azo3973 9.89e-66 211.0 COG3179@1|root,COG3409@1|root,COG3179@2|Bacteria,COG3409@2|Bacteria 2|Bacteria M Peptidoglycan-binding domain 1 protein exeA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 - ko:K02450,ko:K03791,ko:K17733 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko01011,ko02044 9.B.42 GH19 - AAA_22,Glyco_hydro_19,PG_binding_1 k59_1542336_2 298654.FraEuI1c_3295 2.95e-68 224.0 COG0146@1|root,COG0146@2|Bacteria,2IA3H@201174|Actinobacteria 201174|Actinobacteria EQ Hydantoinase B/oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_766610_1 867903.ThesuDRAFT_01689 3.62e-34 129.0 COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,3WCJS@538999|Clostridiales incertae sedis 186801|Clostridia J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_766610_2 882.DVU_0366 8.09e-15 75.9 COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,42TZ2@68525|delta/epsilon subdivisions,2WQJG@28221|Deltaproteobacteria,2MC1P@213115|Desulfovibrionales 28221|Deltaproteobacteria H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig k59_245109_1 1298864.AUEQ01000011_gene291 5.79e-38 143.0 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,236Q3@1762|Mycobacteriaceae 201174|Actinobacteria J Amidase - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_187448_1 66429.JOFL01000006_gene2195 6.67e-34 134.0 COG1020@1|root,COG1052@1|root,COG1020@2|Bacteria,COG1052@2|Bacteria,2GISR@201174|Actinobacteria 201174|Actinobacteria Q Non-ribosomal peptide synthetase modules and related proteins - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C,AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,Thioesterase,ketoacyl-synt k59_717158_1 1229909.NSED_00595 6.84e-76 233.0 COG0368@1|root,arCOG04338@2157|Archaea,41SI6@651137|Thaumarchaeota 651137|Thaumarchaeota H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS - 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CobS k59_975687_1 1336245.JAGO01000004_gene1417 1.9e-73 230.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,1RPJQ@1236|Gammaproteobacteria,1XIEI@135619|Oceanospirillales 135619|Oceanospirillales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF - - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_457493_1 1005048.CFU_4251 1.69e-61 209.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,472UQ@75682|Oxalobacteraceae 28216|Betaproteobacteria I Acetyl propionyl-CoA carboxylase, alpha subunit accA1 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_187476_1 1469245.JFBG01000003_gene399 1.24e-113 340.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1WXK0@135613|Chromatiales 135613|Chromatiales C belongs to the aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.28,1.2.1.79 ko:K00135,ko:K00141 ko00250,ko00310,ko00350,ko00622,ko00623,ko00627,ko00650,ko00760,ko01100,ko01120,ko01220,map00250,map00310,map00350,map00622,map00623,map00627,map00650,map00760,map01100,map01120,map01220 M00027,M00537,M00538 R00713,R00714,R01293,R01419,R02401,R05289,R05663,R05664,R07667 RC00075,RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_352179_2 797114.C475_14338 6.08e-25 111.0 COG2303@1|root,arCOG02233@2157|Archaea,2XU6F@28890|Euryarchaeota,23TIY@183963|Halobacteria 183963|Halobacteria E COG2303 Choline dehydrogenase and related flavoproteins - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_1663263_1 351348.Maqu_1876 3.96e-40 148.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,464FV@72275|Alteromonadaceae 1236|Gammaproteobacteria J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1083632_1 395493.BegalDRAFT_2426 2.96e-59 200.0 COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,1QUBF@1224|Proteobacteria,1RSJ4@1236|Gammaproteobacteria 1236|Gammaproteobacteria C HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide - - - - - - - - - - - - Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases k59_1542378_1 1232410.KI421426_gene1381 3.35e-84 263.0 COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,42QA4@68525|delta/epsilon subdivisions,2WKD1@28221|Deltaproteobacteria,43SDE@69541|Desulfuromonadales 28221|Deltaproteobacteria S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139,DUF4140 k59_144973_1 1120970.AUBZ01000010_gene2190 2.08e-85 265.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,463YV@72275|Alteromonadaceae 1236|Gammaproteobacteria H Glutamate-1-semialdehyde aminotransferase hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUMNK88_1353.UMNK88_158 Aminotran_3 k59_872327_1 1150599.MPHLEI_01366 2.28e-67 225.0 COG0209@1|root,COG0209@2|Bacteria,2GKX9@201174|Actinobacteria,236N9@1762|Mycobacteriaceae 201174|Actinobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdJ GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC k59_1244223_1 247633.GP2143_13216 3.87e-17 85.1 COG2159@1|root,COG2159@2|Bacteria,1RK9M@1224|Proteobacteria,1S78V@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_517396_1 314278.NB231_13091 9.02e-105 334.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales 135613|Chromatiales Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_1510848_1 330214.NIDE0190 5.14e-37 135.0 COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria 2|Bacteria T cobalamin binding ycgE - - ko:K21089,ko:K21972,ko:K22491 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - B12-binding,B12-binding_2,MerR_1 k59_144989_1 706587.Desti_3917 9.31e-07 56.2 COG1597@1|root,COG1597@2|Bacteria,1RIPU@1224|Proteobacteria,43DQE@68525|delta/epsilon subdivisions 1224|Proteobacteria I Diacylglycerol kinase catalytic domain - - - - - - - - - - - - DAGK_cat k59_188114_1 349521.HCH_05840 1.82e-20 89.4 COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1XJEW@135619|Oceanospirillales 135619|Oceanospirillales M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_188114_2 459495.SPLC1_S030930 1.22e-50 172.0 COG3179@1|root,COG4990@1|root,COG3179@2|Bacteria,COG4990@2|Bacteria,1G79T@1117|Cyanobacteria,1HBY3@1150|Oscillatoriales 1117|Cyanobacteria S Papain-like cysteine protease AvrRpt2 - - - - - - - - - - - - Peptidase_C39_2 k59_403222_1 502025.Hoch_5821 1.94e-22 100.0 COG2141@1|root,COG2141@2|Bacteria,1R76K@1224|Proteobacteria 1224|Proteobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_676309_2 391625.PPSIR1_10045 1.29e-17 80.5 COG0858@1|root,COG0858@2|Bacteria 2|Bacteria J rRNA processing rbfA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_300742_1 1408418.JNJH01000001_gene2912 8.33e-14 71.6 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_1664178_1 1177179.A11A3_08485 1.34e-16 79.3 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1XHXW@135619|Oceanospirillales 135619|Oceanospirillales EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_717843_1 1429916.X566_16120 1.18e-89 276.0 COG1960@1|root,COG1960@2|Bacteria,1N05C@1224|Proteobacteria,2TT9T@28211|Alphaproteobacteria,3JTG7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I acyl-CoA dehydrogenase MA20_06725 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_767303_1 420324.KI911999_gene8064 2.96e-63 211.0 28JZZ@1|root,2Z9PZ@2|Bacteria,1N3C6@1224|Proteobacteria,2TSCX@28211|Alphaproteobacteria,1JTZB@119045|Methylobacteriaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_403235_1 675812.VHA_001565 1.15e-33 128.0 COG3067@1|root,COG3067@2|Bacteria,1MV0F@1224|Proteobacteria,1RPE3@1236|Gammaproteobacteria,1XT42@135623|Vibrionales 135623|Vibrionales P ) H( ) antiporter that extrudes sodium in exchange for external protons nhaB GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 - ko:K03314 - - - - ko00000,ko02000 2.A.34.1 - - NhaB k59_403235_2 290398.Csal_1941 7.04e-07 52.0 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,1XHX2@135619|Oceanospirillales 135619|Oceanospirillales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_517423_1 378806.STAUR_1623 7.85e-48 157.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,42TV9@68525|delta/epsilon subdivisions,2WNAN@28221|Deltaproteobacteria,2YV81@29|Myxococcales 28221|Deltaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_1664194_1 203122.Sde_3095 7.71e-27 114.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464X3@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_145008_1 187272.Mlg_1696 1.49e-51 179.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_872364_1 314345.SPV1_10636 8.83e-09 53.1 2E5JD@1|root,330AQ@2|Bacteria,1N86Q@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_872364_2 314345.SPV1_10666 1.65e-28 105.0 28UDP@1|root,2ZGIS@2|Bacteria,1QYVB@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_872364_3 381666.H16_A1978 1.02e-20 90.1 COG2020@1|root,COG2020@2|Bacteria,1MUBZ@1224|Proteobacteria,2VJJ4@28216|Betaproteobacteria,1K3H0@119060|Burkholderiaceae 28216|Betaproteobacteria O Isoprenylcysteine carboxyl methyltransferase - - - - - - - - - - - - ICMT,PEMT k59_1510886_1 251221.35213312 8.44e-32 125.0 COG0457@1|root,COG0457@2|Bacteria,1G31A@1117|Cyanobacteria 1117|Cyanobacteria S tetratricopeptide - - - - - - - - - - - - TPR_16,TPR_8 k59_558758_1 1133569.AHYZ01000061_gene1361 5.09e-05 44.7 COG1217@1|root,COG1217@2|Bacteria,1TQ5Y@1239|Firmicutes,4HAQ6@91061|Bacilli,3F3UK@33958|Lactobacillaceae 91061|Bacilli T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2 k59_558758_2 702113.PP1Y_AT12862 1.29e-18 86.3 COG4221@1|root,COG4221@2|Bacteria,1MVYG@1224|Proteobacteria,2TSTP@28211|Alphaproteobacteria,2K254@204457|Sphingomonadales 204457|Sphingomonadales S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1303364_1 13689.BV96_02367 1.63e-93 292.0 COG1884@1|root,COG1884@2|Bacteria,1R6HS@1224|Proteobacteria,2UQDT@28211|Alphaproteobacteria,2K98J@204457|Sphingomonadales 204457|Sphingomonadales I Methylmalonyl-CoA mutase - - - - - - - - - - - - MM_CoA_mutase k59_1510892_1 42565.FP66_00665 2.63e-28 112.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria,1XH83@135619|Oceanospirillales 135619|Oceanospirillales E Amino acid permease - - - - - - - - - - - - AA_permease_2 k59_1510892_2 342113.DM82_2412 2.12e-34 122.0 COG3791@1|root,COG3791@2|Bacteria,1N6S5@1224|Proteobacteria,2VWNN@28216|Betaproteobacteria,1K87H@119060|Burkholderiaceae 28216|Betaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_976380_1 357804.Ping_0487 2.15e-92 275.0 COG0655@1|root,COG0655@2|Bacteria,1RKK7@1224|Proteobacteria 1224|Proteobacteria S NAD(P)H dehydrogenase (quinone) activity - - - - - - - - - - - - FMN_red k59_717871_1 1220535.IMCC14465_18640 1.63e-54 187.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,4BT88@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Sulfatase - - - - - - - - - - - - Sulfatase k59_767338_1 330214.NIDE3960 2.79e-42 149.0 COG1611@1|root,COG1611@2|Bacteria,3J169@40117|Nitrospirae 40117|Nitrospirae S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_767338_2 330214.NIDE3961 1.44e-27 108.0 COG2404@1|root,COG2404@2|Bacteria,3J12M@40117|Nitrospirae 40117|Nitrospirae S hydrolase activity, acting on ester bonds - - - - - - - - - - - - - k59_1028822_1 1469245.JFBG01000040_gene1733 6.17e-39 145.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1WW3A@135613|Chromatiales 135613|Chromatiales F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_833537_1 227377.CBU_1559 2.39e-24 98.2 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,1S3MU@1236|Gammaproteobacteria,1JCMJ@118969|Legionellales 118969|Legionellales S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_833537_2 1249627.D779_3318 3.43e-28 105.0 COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,1SCJS@1236|Gammaproteobacteria,1WYXS@135613|Chromatiales 135613|Chromatiales S Regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 k59_1451549_1 637905.SVI_2621 8.18e-91 283.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,2QAXB@267890|Shewanellaceae 1236|Gammaproteobacteria M TIGRFAM gamma-glutamyltransferase ggt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - iAPECO1_1312.APECO1_3012,iECOK1_1307.ECOK1_3869,iECS88_1305.ECS88_3844,iECW_1372.ECW_m3706,iEKO11_1354.EKO11_0296,iETEC_1333.ETEC_3693,iUMN146_1321.UM146_17325,iUTI89_1310.UTI89_C3954,iWFL_1372.ECW_m3706 G_glu_transpept k59_610275_1 519989.ECTPHS_02686 1.03e-86 269.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1WWJH@135613|Chromatiales 135613|Chromatiales E peptidase M24B, X-Pro dipeptidase aminopeptidase - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_1303414_1 1123508.JH636440_gene2678 4.81e-71 227.0 COG1454@1|root,COG1454@2|Bacteria,2IXD7@203682|Planctomycetes 203682|Planctomycetes C Iron-containing alcohol dehydrogenase - - 1.1.1.1 ko:K00001,ko:K13954 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH k59_1303420_1 396588.Tgr7_2900 3.25e-78 262.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1664266_1 237368.SCABRO_02677 3.73e-50 182.0 COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,2IX8E@203682|Planctomycetes 203682|Planctomycetes O PA domain - - - - - - - - - - - - PA,PD40,PDZ_2,Peptidase_M28 k59_1510956_1 1532557.JL37_12865 1.52e-12 67.4 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2VRDN@28216|Betaproteobacteria,3T3QT@506|Alcaligenaceae 28216|Betaproteobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_1510956_2 757424.Hsero_4184 8.01e-22 95.5 COG0337@1|root,COG0703@1|root,COG0337@2|Bacteria,COG0703@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,4725Y@75682|Oxalobacteraceae 28216|Betaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,SKI k59_17669_1 1382359.JIAL01000001_gene1033 3.64e-05 51.6 COG3391@1|root,COG3391@2|Bacteria,3Y2SU@57723|Acidobacteria,2JKB8@204432|Acidobacteriia 204432|Acidobacteriia S TIGRFAM 40-residue YVTN family beta-propeller repeat - - - - - - - - - - - - Cytochrom_D1 k59_610291_1 519989.ECTPHS_00310 5.19e-84 262.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales 135613|Chromatiales J Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_1337629_1 1448860.BBJO01000024_gene3072 9.21e-08 58.5 COG0168@1|root,arCOG04145@2157|Archaea,2XT89@28890|Euryarchaeota,23S54@183963|Halobacteria 183963|Halobacteria P COG0168 Trk-type K transport systems, membrane components - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_188200_2 880072.Desac_0501 2.29e-09 58.9 COG2202@1|root,COG2204@1|root,COG3290@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3290@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_833571_1 1123242.JH636434_gene4370 3.35e-18 89.7 COG0642@1|root,COG2205@2|Bacteria,2IX1S@203682|Planctomycetes 203682|Planctomycetes T Histidine kinase - - - - - - - - - - - - Ammonium_transp,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,Response_reg k59_300820_1 2340.JV46_07520 1.03e-68 218.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,1J4WN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475 TGT k59_300820_2 94624.Bpet3646 3.92e-70 223.0 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,2VHJF@28216|Betaproteobacteria,3T1KD@506|Alcaligenaceae 28216|Betaproteobacteria J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_1145743_2 497964.CfE428DRAFT_2599 3.07e-08 57.0 COG2204@1|root,COG2204@2|Bacteria,46SDB@74201|Verrucomicrobia 74201|Verrucomicrobia T sigma-54 factor interaction domain-containing protein - - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1036365_1 1122185.N792_10870 3.46e-78 255.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1X4Z1@135614|Xanthomonadales 135614|Xanthomonadales G phosphomannomutase - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1552886_2 323261.Noc_0154 2.73e-13 70.1 COG4976@1|root,COG4976@2|Bacteria,1RA4U@1224|Proteobacteria 1224|Proteobacteria S Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_1401846_1 1435356.Y013_21790 0.000617 47.4 COG2813@1|root,COG2813@2|Bacteria,2I8VY@201174|Actinobacteria,4FUJY@85025|Nocardiaceae 201174|Actinobacteria J Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA rlmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052916,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.172,2.1.1.174 ko:K00564,ko:K11391 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - MTS k59_1608972_1 59196.RICGR_1234 5.15e-37 136.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1JD6R@118969|Legionellales 118969|Legionellales F Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK k59_1608972_2 589873.EP13_09385 2.31e-26 103.0 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,464GE@72275|Alteromonadaceae 1236|Gammaproteobacteria M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008690,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019294,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046394,GO:0046400,GO:0046401,GO:0046872,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - iAF1260.b0918,iB21_1397.B21_00929,iBWG_1329.BWG_0770,iECBD_1354.ECBD_2677,iECB_1328.ECB_00922,iECDH10B_1368.ECDH10B_0988,iECDH1ME8569_1439.ECDH1ME8569_0869,iECD_1391.ECD_00922,iETEC_1333.ETEC_0986,iEcDH1_1363.EcDH1_2725,iEcHS_1320.EcHS_A1025,iEcolC_1368.EcolC_2678,iJO1366.b0918,iJR904.b0918,iPC815.YPO1400,iUMNK88_1353.UMNK88_1071,iY75_1357.Y75_RS04770 CTP_transf_3 k59_1147155_1 1150626.PHAMO_20024 9.16e-32 120.0 COG0398@1|root,COG0398@2|Bacteria,1RDYV@1224|Proteobacteria,2U7GT@28211|Alphaproteobacteria,2JSDS@204441|Rhodospirillales 204441|Rhodospirillales S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_1608973_2 330214.NIDE4089 6.55e-58 190.0 COG1702@1|root,COG1702@2|Bacteria,3J0AD@40117|Nitrospirae 40117|Nitrospirae T PhoH-like protein - - - ko:K06217 - - - - ko00000 - - - PhoH k59_362054_1 404589.Anae109_2198 7.46e-58 201.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2YUBZ@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdA1 - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC k59_620493_1 494416.AYXN01000042_gene1804 3.6e-28 119.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,3NJSZ@468|Moraxellaceae 1236|Gammaproteobacteria M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0009636,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042221,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0050896,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:1901264 - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - iG2583_1286.G2583_0058 OstA,OstA_C k59_1190256_1 929712.KI912613_gene4546 6.74e-50 181.0 COG2937@1|root,COG2937@2|Bacteria,2GMQF@201174|Actinobacteria 201174|Actinobacteria I Belongs to the GPAT DAPAT family plsB1 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_1190259_1 349521.HCH_00561 1.65e-88 275.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,1RPM0@1236|Gammaproteobacteria,1XHJI@135619|Oceanospirillales 135619|Oceanospirillales H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_1401863_1 1268622.AVS7_00055 2.44e-63 220.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2VNK7@28216|Betaproteobacteria,4AA8Z@80864|Comamonadaceae 28216|Betaproteobacteria NU PFAM type II and III secretion system protein - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_880949_1 580332.Slit_1721 3.74e-37 128.0 2EJVG@1|root,318S5@2|Bacteria,1Q0VB@1224|Proteobacteria,2W5S9@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF4279) - - - - - - - - - - - - DUF4279 k59_413381_1 713586.KB900536_gene528 8.93e-43 150.0 COG0526@1|root,COG4243@1|root,COG0526@2|Bacteria,COG4243@2|Bacteria,1QQS9@1224|Proteobacteria,1SKP7@1236|Gammaproteobacteria 1236|Gammaproteobacteria CO Vitamin K epoxide reductase family - - - - - - - - - - - - VKOR k59_984170_1 1161401.ASJA01000003_gene3004 5.79e-21 89.7 COG1028@1|root,COG1028@2|Bacteria,1MWGC@1224|Proteobacteria,2TSNX@28211|Alphaproteobacteria,43XAG@69657|Hyphomonadaceae 28211|Alphaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) MA20_31005 - - - - - - - - - - - adh_short_C2 k59_984170_2 1282876.BAOK01000002_gene549 3.97e-39 141.0 COG1960@1|root,COG1960@2|Bacteria,1QU1U@1224|Proteobacteria,2TRIU@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_937420_1 1487953.JMKF01000028_gene1341 8.5e-90 277.0 COG0598@1|root,COG0598@2|Bacteria,1G1AG@1117|Cyanobacteria,1H99G@1150|Oscillatoriales 1117|Cyanobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_880959_1 177437.HRM2_15160 2.44e-26 114.0 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,2MMPS@213118|Desulfobacterales 28221|Deltaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family actB - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_198494_1 1123258.AQXZ01000018_gene894 0.00098 42.0 COG0155@1|root,COG0155@2|Bacteria,2GJRN@201174|Actinobacteria,4G1CI@85025|Nocardiaceae 201174|Actinobacteria C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family - - 1.7.7.1,1.8.1.2,1.8.7.1 ko:K00366,ko:K00381,ko:K00392 ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120 M00176,M00531 R00790,R00858,R00859,R03600 RC00065,RC00176 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_198494_2 502025.Hoch_5120 3.47e-16 78.6 2DUA0@1|root,33PJB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_362089_1 1288826.MSNKSG1_03690 3.88e-35 138.0 COG1025@1|root,COG1025@2|Bacteria,1QTVC@1224|Proteobacteria,1T1IG@1236|Gammaproteobacteria,4641E@72275|Alteromonadaceae 1236|Gammaproteobacteria O Belongs to the peptidase M16 family ptrA - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C,Peptidase_M16_M k59_1147210_1 457396.CSBG_03129 1.81e-54 183.0 COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,24864@186801|Clostridia,36E3K@31979|Clostridiaceae 186801|Clostridia H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_1552947_1 436308.Nmar_0436 2.31e-30 112.0 COG1382@1|root,arCOG01342@2157|Archaea,41SPD@651137|Thaumarchaeota 651137|Thaumarchaeota O Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding pfdB - - ko:K04798 - - - - ko00000,ko03110 - - - Prefoldin_2 k59_1552947_2 1229909.NSED_02270 1.31e-33 121.0 COG1948@1|root,arCOG04206@2157|Archaea,41SIH@651137|Thaumarchaeota 651137|Thaumarchaeota L ERCC4 domain - - - ko:K10848 ko03420,ko03460,map03420,map03460 - - - ko00000,ko00001,ko01000,ko03032,ko03400 - - - ERCC4,HHH_5 k59_880976_1 330214.NIDE4312 5.21e-79 245.0 COG0330@1|root,COG0330@2|Bacteria,3J0NF@40117|Nitrospirae 40117|Nitrospirae O prohibitin homologues - - - - - - - - - - - - Band_7 k59_1401894_1 1123053.AUDG01000062_gene82 3.38e-36 135.0 COG2067@1|root,COG2067@2|Bacteria,1PXPC@1224|Proteobacteria,1RQKS@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Protein of unknown function (DUF3570) - - - - - - - - - - - - DUF3570 k59_1401894_2 1128912.GMES_2335 2.27e-27 101.0 2E3QA@1|root,32YN8@2|Bacteria,1N98P@1224|Proteobacteria,1SCNQ@1236|Gammaproteobacteria,4691P@72275|Alteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4266) - - - - - - - - - - - - DUF4266 k59_1401894_3 572477.Alvin_0146 1.34e-38 136.0 COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,1S8UU@1236|Gammaproteobacteria,1WZ4W@135613|Chromatiales 135613|Chromatiales CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA,Redoxin k59_1460500_1 926550.CLDAP_27080 1.78e-57 195.0 COG4992@1|root,COG4992@2|Bacteria,2G5TW@200795|Chloroflexi 2|Bacteria E TIGRFAM acetylornithine and succinylornithine aminotransferase patA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0033094,GO:0034641,GO:0036094,GO:0042402,GO:0042802,GO:0043167,GO:0043168,GO:0044106,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:0097164,GO:1901363,GO:1901564,GO:1901565,GO:1901575 2.6.1.11,2.6.1.17,2.6.1.82 ko:K00821,ko:K05830,ko:K09251 ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00031,M00763,M00845 R01155,R02283,R04475,R09778,R10932 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - iECIAI1_1343.ECIAI1_3220,iECSF_1327.ECSF_2916,iECs_1301.ECs3955,iZ_1308.Z4426 Aminotran_3 k59_620560_1 929558.SMGD1_1182 6.4e-13 79.3 COG3164@1|root,COG3164@2|Bacteria,1QUYX@1224|Proteobacteria,43CES@68525|delta/epsilon subdivisions,2YTC9@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748 k59_198537_1 243231.GSU2919 1.23e-106 316.0 COG3959@1|root,COG3959@2|Bacteria,1MWRX@1224|Proteobacteria,42P7U@68525|delta/epsilon subdivisions,2WKZQ@28221|Deltaproteobacteria,43RXC@69541|Desulfuromonadales 28221|Deltaproteobacteria G PFAM Transketolase domain protein tklA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_154243_1 329726.AM1_1920 6.18e-17 77.8 2DQ7S@1|root,3355J@2|Bacteria,1GA7T@1117|Cyanobacteria 1117|Cyanobacteria S Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core3 k59_362128_1 1121405.dsmv_0890 6.12e-82 258.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42MF0@68525|delta/epsilon subdivisions,2WMC1@28221|Deltaproteobacteria,2MIDP@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase for insertion sequences IS1326 IS1353 (IS21 IS408 IS1162 family protein) - - - - - - - - - - - - rve k59_254470_2 1085623.GNIT_0293 6.55e-22 90.5 2EH48@1|root,338P5@2|Bacteria,1NFS9@1224|Proteobacteria,1SH7Q@1236|Gammaproteobacteria,46CA5@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_413453_1 768066.HELO_1330 1.68e-72 229.0 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,1XHHX@135619|Oceanospirillales 135619|Oceanospirillales J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_620580_1 563192.HMPREF0179_03207 6.16e-34 123.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42P61@68525|delta/epsilon subdivisions,2X5PQ@28221|Deltaproteobacteria,2MGU3@213115|Desulfovibrionales 28221|Deltaproteobacteria P Ferric uptake regulator family - - - ko:K03711 - - - - ko00000,ko03000 - - - FUR,FeoA k59_620582_1 1469245.JFBG01000057_gene2374 5.45e-43 150.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1WW0A@135613|Chromatiales 1236|Gammaproteobacteria Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_1037424_1 713586.KB900536_gene2226 1.75e-104 332.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_8 k59_1253518_1 1123229.AUBC01000004_gene3156 2.78e-30 120.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18989 - M00720 - - ko00000,ko00002,ko02000 2.A.6.2.30 - - ACR_tran k59_984247_1 314607.KB13_1097 4.88e-12 64.7 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2VRPJ@28216|Betaproteobacteria,1KQRJ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_984247_2 1500893.JQNB01000001_gene3386 3.92e-20 85.1 COG2166@1|root,COG2166@2|Bacteria,1RI8F@1224|Proteobacteria,1S852@1236|Gammaproteobacteria,1XCMB@135614|Xanthomonadales 135614|Xanthomonadales S SufE protein probably involved in Fe-S center assembly - - - ko:K02426 - - - - ko00000 - - - SufE k59_1460544_1 316067.Geob_0570 9.14e-84 254.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,4374P@68525|delta/epsilon subdivisions,2WKF6@28221|Deltaproteobacteria 28221|Deltaproteobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1147294_1 365528.KB891263_gene539 4.28e-12 70.5 COG0725@1|root,COG0725@2|Bacteria,2GMPF@201174|Actinobacteria,4ESN3@85013|Frankiales 201174|Actinobacteria P TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_775628_1 82654.Pse7367_1114 1.85e-68 219.0 COG2230@1|root,COG2230@2|Bacteria,1G3TN@1117|Cyanobacteria,1H8KG@1150|Oscillatoriales 1117|Cyanobacteria M Methylase involved in ubiquinone menaquinone biosynthesis - - - - - - - - - - - - Methyltransf_31 k59_310379_2 396588.Tgr7_1833 3.2e-68 218.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1WWGC@135613|Chromatiales 135613|Chromatiales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1401963_1 76114.ebA4059 3.96e-39 143.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2VIIH@28216|Betaproteobacteria,2KU75@206389|Rhodocyclales 206389|Rhodocyclales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_362168_1 439235.Dalk_1725 4.57e-104 320.0 COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,42QI1@68525|delta/epsilon subdivisions,2WMJR@28221|Deltaproteobacteria,2MMRG@213118|Desulfobacterales 28221|Deltaproteobacteria I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_198586_1 888727.HMPREF9092_0453 2.97e-48 179.0 COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia,3WD2E@538999|Clostridiales incertae sedis 186801|Clostridia I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1553037_1 1283079.M1IPQ2_9CAUD 2e-24 102.0 4QCRK@10239|Viruses,4QUU9@35237|dsDNA viruses no RNA stage,4QPSI@28883|Caudovirales,4QNJT@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_1401964_1 1167006.UWK_03488 3.37e-79 246.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,42MCP@68525|delta/epsilon subdivisions,2WJDS@28221|Deltaproteobacteria,2MHYY@213118|Desulfobacterales 28221|Deltaproteobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - iAF987.Gmet_0409 Glycos_transf_4,MraY_sig1 k59_775642_1 269482.Bcep1808_2007 1.47e-116 370.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,1K1R9@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_984296_1 1192034.CAP_2431 1.76e-55 192.0 COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,42MZZ@68525|delta/epsilon subdivisions,2WIQI@28221|Deltaproteobacteria 28221|Deltaproteobacteria H MoeA domain protein domain I and II - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1253560_1 2340.JV46_06790 3.71e-69 225.0 COG2170@1|root,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,1RPKZ@1236|Gammaproteobacteria,1J4M1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S glutamate--cysteine ligase ybdK_1 - - - - - - - - - - - GCS2 k59_1253560_2 321332.CYB_0777 1.76e-57 189.0 COG2988@1|root,COG2988@2|Bacteria,1GC3T@1117|Cyanobacteria,1GZBM@1129|Synechococcus 1117|Cyanobacteria E Succinylglutamate desuccinylase / Aspartoacylase family - - - - - - - - - - - - AstE_AspA k59_1093983_1 1469245.JFBG01000040_gene1729 8.4e-123 369.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria,1WX2Y@135613|Chromatiales 135613|Chromatiales I synthetase - - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_620648_1 748247.AZKH_p0222 1.67e-81 253.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria,2KX8V@206389|Rhodocyclales 206389|Rhodocyclales L Group II intron, maturase-specific domain - - - - - - - - - - - - GIIM,RVT_1 k59_154307_1 331869.BAL199_10562 3.18e-40 138.0 COG2142@1|root,COG2142@2|Bacteria,1MZND@1224|Proteobacteria,2U94P@28211|Alphaproteobacteria,4BR1M@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C succinate dehydrogenase sdhD - - ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_154307_2 1380391.JIAS01000019_gene1381 2.6e-25 103.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2TQJA@28211|Alphaproteobacteria,2JP96@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_413537_1 1300345.LF41_2777 3.82e-66 213.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1X3B7@135614|Xanthomonadales 135614|Xanthomonadales J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_1253581_1 572477.Alvin_2328 2.5e-87 270.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWT4@135613|Chromatiales 135613|Chromatiales U Ammonium transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_413540_1 1408254.T458_16980 2.12e-23 100.0 COG1714@1|root,COG1714@2|Bacteria,1UWM8@1239|Firmicutes,4HBNM@91061|Bacilli,26X3P@186822|Paenibacillaceae 91061|Bacilli S RDD family - - - - - - - - - - - - RDD k59_21752_1 1267535.KB906767_gene823 3.86e-62 216.0 COG1198@1|root,COG1198@2|Bacteria,3Y2NY@57723|Acidobacteria,2JI1K@204432|Acidobacteriia 204432|Acidobacteriia L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_21752_2 186490.IM45_929 3.92e-05 45.4 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1J5V6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0008463,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043021,GO:0043022,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046872,GO:0046914,GO:0071704,GO:1901564 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_620684_2 1469245.JFBG01000063_gene2351 6.33e-14 72.0 COG0112@1|root,COG0404@1|root,COG0112@2|Bacteria,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1WWZ0@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_413547_1 272630.MexAM1_META1p1077 9.5e-06 51.2 COG5266@1|root,COG5266@2|Bacteria,1RGKP@1224|Proteobacteria,2U8CG@28211|Alphaproteobacteria,1JTTN@119045|Methylobacteriaceae 28211|Alphaproteobacteria P Domain of unknown function (DUF4198) - - - - - - - - - - - - DUF4198 k59_775678_1 926551.KB900703_gene1073 1.1e-11 69.7 COG0739@1|root,COG0739@2|Bacteria,4NGHH@976|Bacteroidetes,1HX46@117743|Flavobacteriia,1EQKX@1016|Capnocytophaga 976|Bacteroidetes M Peptidase, M23 mepM_1 - - - - - - - - - - - Peptidase_M23 k59_1147377_1 96561.Dole_2297 1.26e-79 249.0 COG2768@1|root,COG2768@2|Bacteria,1MXMK@1224|Proteobacteria,42M2Z@68525|delta/epsilon subdivisions,2WIN6@28221|Deltaproteobacteria,2MI71@213118|Desulfobacterales 28221|Deltaproteobacteria C Domain of unknown function (DUF362) - - - ko:K07138 - - - - ko00000 - - - DUF362,Fer4,Fer4_4,Fer4_6,Fer4_7 k59_891033_1 1469245.JFBG01000014_gene2039 1.14e-126 368.0 COG4521@1|root,COG4521@2|Bacteria,1MVH2@1224|Proteobacteria,1RRRT@1236|Gammaproteobacteria 1236|Gammaproteobacteria P taurine ABC transporter - - - ko:K15551 ko00920,ko02010,map00920,map02010 M00435 - - ko00000,ko00001,ko00002,ko02000 3.A.1.17.1,3.A.1.17.4 - - NMT1 k59_891033_2 1469245.JFBG01000014_gene2038 1.15e-105 312.0 COG4525@1|root,COG4525@2|Bacteria,1QTUA@1224|Proteobacteria,1RPAF@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system tauB - 3.6.3.36 ko:K10831 ko00920,ko02010,map00920,map02010 M00435 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.17.1,3.A.1.17.4 - - ABC_tran k59_1151819_2 69014.TK1032 5.31e-57 194.0 COG0309@1|root,arCOG00636@2157|Archaea,2XTX2@28890|Euryarchaeota,242XP@183968|Thermococci 183968|Thermococci O AIR synthase related protein, C-terminal domain - - - - - - - - - - - - AIRS,AIRS_C k59_1204966_1 41431.PCC8801_1357 1.28e-19 84.0 COG1246@1|root,COG1246@2|Bacteria,1G856@1117|Cyanobacteria 1117|Cyanobacteria E Acetyltransferase (GNAT) domain - - - ko:K03830 - - - - ko00000,ko01000 - - - Acetyltransf_10 k59_1204966_2 1201288.M900_1471 7.28e-60 189.0 COG1432@1|root,COG1432@2|Bacteria 2|Bacteria S NYN domain MA20_36560 - - ko:K06860 - - - - ko00000 - - - NYN k59_838702_1 686340.Metal_1905 8.66e-06 50.8 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1XEAS@135618|Methylococcales 135618|Methylococcales M Soluble lytic murein transglycosylase L domain - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_838702_2 1444711.CCJF01000005_gene1660 0.000769 42.0 COG0730@1|root,COG0730@2|Bacteria,2JH1J@204428|Chlamydiae 204428|Chlamydiae S Sulfite exporter TauE/SafE - - - - - - - - - - - - TauE k59_1308441_1 242619.PG_1779 6.57e-22 90.5 COG2110@1|root,COG2110@2|Bacteria,4NNRH@976|Bacteroidetes,2FMVR@200643|Bacteroidia,22Y29@171551|Porphyromonadaceae 976|Bacteroidetes S Appr-1'-p processing enzyme - - - - - - - - - - - - Macro k59_1308441_2 105559.Nwat_2750 9.61e-22 90.9 COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,1RY2B@1236|Gammaproteobacteria,1WY1Q@135613|Chromatiales 135613|Chromatiales S PFAM transport-associated - - - - - - - - - - - - BON k59_995019_1 338966.Ppro_0302 1.39e-05 50.8 COG0775@1|root,COG0775@2|Bacteria,1Q1C0@1224|Proteobacteria,43EX0@68525|delta/epsilon subdivisions,2WRFZ@28221|Deltaproteobacteria,43V4A@69541|Desulfuromonadales 28221|Deltaproteobacteria F PFAM purine or other phosphorylase family 1 - - 3.2.2.9 ko:K01243 ko00270,ko01100,ko01230,map00270,map01100,map01230 M00034,M00609 R00194,R01401 RC00063,RC00318 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_630424_1 298655.KI912266_gene4067 1.02e-65 224.0 COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4EUVK@85013|Frankiales 201174|Actinobacteria C Molydopterin dinucleotide binding domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1412934_1 1211815.CBYP010000006_gene302 3e-59 206.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2GN09@201174|Actinobacteria,4ERS2@85013|Frankiales 201174|Actinobacteria E Glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_787061_1 665571.STHERM_c19690 0.000485 48.9 COG0760@1|root,COG0760@2|Bacteria 2|Bacteria O peptidyl-prolyl cis-trans isomerase activity - - 5.2.1.8 ko:K03769,ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_734241_1 521095.Apar_1092 4.49e-29 111.0 COG0125@1|root,COG0125@2|Bacteria,2GNTI@201174|Actinobacteria,4CVPV@84998|Coriobacteriia 84998|Coriobacteriia F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_734241_2 1123519.PSJM300_12760 1.47e-23 97.4 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1Z2CS@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901564 - ko:K07082 - - - - ko00000 - - - YceG k59_1465706_1 977880.RALTA_B1781 9.14e-49 173.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VMNB@28216|Betaproteobacteria,1K1HE@119060|Burkholderiaceae 28216|Betaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B coxN - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_1569696_1 66875.JODY01000034_gene2963 1.87e-08 58.5 COG0463@1|root,COG1887@1|root,COG0463@2|Bacteria,COG1887@2|Bacteria,2GM0T@201174|Actinobacteria 201174|Actinobacteria M CDP-glycerol poly(glycerophosphate) glycerophosphotransferase - - 2.7.8.12 ko:K09809 - - - - ko00000,ko01000 - - - Glycos_transf_2,Glyphos_transf k59_630445_1 1121939.L861_12675 8.44e-10 58.9 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1RQ2D@1236|Gammaproteobacteria,1XIV6@135619|Oceanospirillales 135619|Oceanospirillales I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases - - 1.1.1.60 ko:K00042 ko00630,ko01100,map00630,map01100 - R01745,R01747 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_630445_2 301.JNHE01000007_gene1322 3.72e-125 363.0 COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,1RQF9@1236|Gammaproteobacteria,1YF3M@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria G Belongs to the hyi family hyi GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0008903,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019752,GO:0032787,GO:0042802,GO:0042803,GO:0043436,GO:0044237,GO:0044281,GO:0046487,GO:0046983,GO:0071704 5.3.1.22 ko:K01816 ko00630,ko01100,map00630,map01100 - R01394 RC00511 ko00000,ko00001,ko01000 - - iECO103_1326.ECO103_0481,iECO111_1330.ECO111_0541,iECO26_1355.ECO26_0541 AP_endonuc_2 k59_1205001_1 1267005.KB911256_gene1874 9.8e-27 107.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Serine-pyruvate aminotransferase archaeal aspartate aminotransferase sgaA - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_1205001_2 1095747.HMPREF1049_0103 1.7e-05 46.2 COG0626@1|root,COG0626@2|Bacteria,379KB@32066|Fusobacteria 32066|Fusobacteria E Psort location Cytoplasmic, score 9.97 megL GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0016740,GO:0016765,GO:0016829,GO:0016846 4.4.1.11 ko:K01761 ko00270,ko00450,map00270,map00450 - R00654,R04770 RC00196,RC00348,RC01209,RC01210 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_107042_2 323848.Nmul_A2554 1.68e-35 122.0 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2VU1D@28216|Betaproteobacteria,373G3@32003|Nitrosomonadales 28216|Betaproteobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_107042_3 1283300.ATXB01000001_gene1548 4.91e-103 311.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1XDR2@135618|Methylococcales 135618|Methylococcales J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_1465721_1 1123519.PSJM300_04925 7.36e-06 47.0 COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,1RMCD@1236|Gammaproteobacteria,1Z0U7@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria F Belongs to the dCTP deaminase family dcd GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0015949,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO1525 DCD,dUTPase k59_577396_2 247634.GPB2148_1120 8.15e-113 342.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1J88C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.99.10 ko:K22445 - - - - ko00000,ko01000 - - - Aldedh k59_891082_1 314278.NB231_15768 1.26e-66 222.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1WVZJ@135613|Chromatiales 135613|Chromatiales U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_107045_1 1189612.A33Q_0559 5.69e-53 183.0 COG0119@1|root,COG0119@2|Bacteria,4NF3N@976|Bacteroidetes,47JWF@768503|Cytophagia 976|Bacteroidetes E Belongs to the alpha-IPM synthase homocitrate synthase family leuA_1 - 2.3.1.182 ko:K09011 ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230 M00535 R07399 RC00004,RC01205 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1205007_2 697282.Mettu_0145 2.08e-35 132.0 COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria,1XEXY@135618|Methylococcales 135618|Methylococcales S SURF1-like protein - - - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 k59_995040_1 445686.E3SKU6_9CAUD 5.5e-160 512.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_420846_1 1282876.BAOK01000001_gene2729 1.71e-97 291.0 COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2TUAZ@28211|Alphaproteobacteria,4BRW1@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Metallo-beta-lactamase superfamily MA20_07390 - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B k59_1205015_1 983545.Glaag_4274 2.32e-85 269.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,46440@72275|Alteromonadaceae 1236|Gammaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_316537_3 462590.A9J580_BPPYU 1.59e-44 159.0 4QB49@10239|Viruses,4QUZD@35237|dsDNA viruses no RNA stage,4QPU2@28883|Caudovirales,4QKRQ@10699|Siphoviridae 10699|Siphoviridae S Domain of unknown function (DUF4055) - - - - - - - - - - - - - k59_1257182_1 1123368.AUIS01000020_gene1080 4.26e-165 473.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,2NCEJ@225057|Acidithiobacillales 225057|Acidithiobacillales E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_1412974_1 2340.JV46_15690 4.78e-19 86.7 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,1J4SN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_1412974_2 395493.BegalDRAFT_2911 1.36e-72 244.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,45ZWT@72273|Thiotrichales 72273|Thiotrichales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_420854_1 331869.BAL199_08938 6.15e-137 402.0 COG0747@1|root,COG0747@2|Bacteria,1MUPE@1224|Proteobacteria,2TS4U@28211|Alphaproteobacteria,4BQ8P@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E transport system, periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_942900_1 671143.DAMO_0872 1.55e-56 183.0 COG2267@1|root,COG2267@2|Bacteria,2NRR1@2323|unclassified Bacteria 2|Bacteria I Alpha/beta hydrolase family - - 3.1.1.24 ko:K01055 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00568 R02991 RC00825 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1 k59_1151883_2 402881.Plav_2501 1.12e-23 99.4 COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2U36X@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_682696_1 330214.NIDE4030 1.56e-87 280.0 COG5009@1|root,COG5009@2|Bacteria,3J0BH@40117|Nitrospirae 40117|Nitrospirae M Penicillin-binding protein OB-like domain - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_1308502_1 1286106.MPL1_02228 7.56e-13 67.0 COG2227@1|root,COG2227@2|Bacteria,1RE7I@1224|Proteobacteria,1S6PD@1236|Gammaproteobacteria,463V6@72273|Thiotrichales 72273|Thiotrichales H PFAM Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_25,TehB k59_1308502_2 349521.HCH_04774 1.77e-67 212.0 COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,1S3XT@1236|Gammaproteobacteria,1XJJU@135619|Oceanospirillales 135619|Oceanospirillales M Transglycosylase SLT domain - - - - - - - - - - - - SLT k59_1151885_1 485913.Krac_5504 8.84e-50 176.0 COG4584@1|root,COG4584@2|Bacteria 2|Bacteria L PFAM Integrase catalytic - - - - - - - - - - - - rve k59_1151885_2 1121438.JNJA01000060_gene1623 9.2e-44 148.0 COG1484@1|root,COG1484@2|Bacteria 2|Bacteria L DNA-dependent DNA replication - - - ko:K02315 - - - - ko00000,ko03032 - - - IstB_IS21 k59_891111_1 395493.BegalDRAFT_0348 3.03e-78 240.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,1RP6E@1236|Gammaproteobacteria,460G9@72273|Thiotrichales 72273|Thiotrichales L Hydrolase, TatD family - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_1257209_1 1114959.SZMC14600_16641 1.65e-42 153.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4DZ1Z@85010|Pseudonocardiales 201174|Actinobacteria C PFAM CoA-transferase family III - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_838772_1 1116472.MGMO_91c00200 2.79e-35 125.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1XF14@135618|Methylococcales 135618|Methylococcales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions - - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_838772_2 694569.D7S_01787 2.44e-25 105.0 COG0144@1|root,COG0223@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0223@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1Y781@135625|Pasteurellales 135625|Pasteurellales J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA rsmB GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB k59_734295_1 565045.NOR51B_2533 2.44e-58 191.0 COG0625@1|root,COG0625@2|Bacteria,1P71B@1224|Proteobacteria,1RQZH@1236|Gammaproteobacteria,1J88N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0625 Glutathione S-transferase - - - - - - - - - - - - GST_C,GST_C_2,GST_N_3 k59_159223_1 349965.yinte0001_15300 5.7e-34 128.0 COG0697@1|root,COG0697@2|Bacteria,1MXJY@1224|Proteobacteria,1RNSM@1236|Gammaproteobacteria,41EM2@629|Yersinia 1236|Gammaproteobacteria EG EamA-like transporter family pagO - - - - - - - - - - - EamA k59_839486_1 1192034.CAP_5550 2.84e-95 304.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2YUPG@29|Myxococcales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1570432_2 46234.ANA_C11347 8.72e-56 182.0 COG3409@1|root,COG3772@1|root,COG3409@2|Bacteria,COG3772@2|Bacteria,1G6C9@1117|Cyanobacteria,1HS4E@1161|Nostocales 1117|Cyanobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - PG_binding_1,Phage_lysozyme k59_421590_1 497321.C664_17442 5.02e-27 102.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VK9J@28216|Betaproteobacteria,2KUE1@206389|Rhodocyclales 206389|Rhodocyclales L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_421590_2 552811.Dehly_0649 6.32e-76 253.0 COG3039@1|root,COG4198@1|root,COG3039@2|Bacteria,COG4198@2|Bacteria,2G9US@200795|Chloroflexi,34D8F@301297|Dehalococcoidia 2|Bacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF1015,DUF772 k59_1205964_2 81824.XP_001746029.1 4.38e-45 159.0 COG1218@1|root,KOG1528@2759|Eukaryota,38CH8@33154|Opisthokonta 33154|Opisthokonta FP 3'(2'),5'-bisphosphate nucleotidase activity MET22 GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0004441,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006970,GO:0006972,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009628,GO:0009651,GO:0009987,GO:0016053,GO:0016311,GO:0016312,GO:0016787,GO:0016788,GO:0016791,GO:0019752,GO:0023052,GO:0035556,GO:0042538,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046030,GO:0046394,GO:0048015,GO:0048017,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052829,GO:0065007,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_1100760_1 471852.Tcur_2011 9.84e-104 307.0 COG1028@1|root,COG1028@2|Bacteria,2GK47@201174|Actinobacteria,4EGRA@85012|Streptosporangiales 201174|Actinobacteria IQ KR domain rhlG - 1.1.1.69 ko:K00046 - - - - ko00000,ko01000 - - - adh_short_C2 k59_1205967_1 1262915.BN574_01337 4.87e-51 180.0 COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,4H2PN@909932|Negativicutes 909932|Negativicutes J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon,tRNA_bind k59_369414_1 316275.VSAL_I1839 4.48e-70 222.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,1XU10@135623|Vibrionales 135623|Vibrionales C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_525946_1 1384054.N790_13500 1.8e-12 67.8 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1X3IF@135614|Xanthomonadales 135614|Xanthomonadales C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) ctaC - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_525946_2 105559.Nwat_3100 8.87e-11 61.6 COG5488@1|root,COG5488@2|Bacteria,1N9B7@1224|Proteobacteria,1SF1J@1236|Gammaproteobacteria,1X1FG@135613|Chromatiales 135613|Chromatiales S Integral membrane protein (DUF2244) - - - - - - - - - - - - DUF2244 k59_631393_1 466038.KI421440_gene249 6.04e-107 321.0 COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2U0KM@28211|Alphaproteobacteria,4BSBD@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Receptor family ligand binding region MA20_16480 - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1100767_1 497964.CfE428DRAFT_1457 7.45e-42 154.0 COG2804@1|root,COG2804@2|Bacteria,46SDR@74201|Verrucomicrobia 74201|Verrucomicrobia NU General secretory system II protein E domain protein pulE - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_473444_1 273068.TTE2458 1.19e-17 87.0 COG2211@1|root,COG2211@2|Bacteria,1TR5B@1239|Firmicutes,249ZF@186801|Clostridia,42HX6@68295|Thermoanaerobacterales 186801|Clostridia G MFS/sugar transport protein - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_1517333_2 1036674.A28LD_1047 5.65e-39 132.0 COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,1S62I@1236|Gammaproteobacteria,2QGXP@267893|Idiomarinaceae 1236|Gammaproteobacteria S Belongs to the UPF0145 family - - - - - - - - - - - - YbjQ_1 k59_735001_1 1232410.KI421412_gene146 1.96e-112 341.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2WJQS@28221|Deltaproteobacteria,43TIF@69541|Desulfuromonadales 28221|Deltaproteobacteria C Nickel-dependent hydrogenase hyaL - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_317393_1 744980.TRICHSKD4_0819 2.63e-07 51.2 COG0520@1|root,COG0520@2|Bacteria,1QU0N@1224|Proteobacteria,2TW6K@28211|Alphaproteobacteria 28211|Alphaproteobacteria E aminotransferase class V - - - - - - - - - - - - Aminotran_5 k59_999386_1 526225.Gobs_3683 1.18e-92 281.0 COG1052@1|root,COG1052@2|Bacteria,2I2IC@201174|Actinobacteria,4ETVD@85013|Frankiales 201174|Actinobacteria CH D-isomer specific 2-hydroxyacid dehydrogenase serA2 - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_1104931_1 228410.NE1322 1.46e-77 237.0 COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2VHHT@28216|Betaproteobacteria,3728F@32003|Nitrosomonadales 28216|Betaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_1104931_2 765914.ThisiDRAFT_0208 3.99e-57 187.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1WWXU@135613|Chromatiales 135613|Chromatiales EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_62106_1 1120941.AUBL01000048_gene2715 6.34e-43 151.0 COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4D4MV@85005|Actinomycetales 201174|Actinobacteria V ABC transporter, ATP-binding protein - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1313381_1 573413.Spirs_3186 2.8e-05 45.8 COG0268@1|root,COG0268@2|Bacteria,2J84G@203691|Spirochaetes 203691|Spirochaetes J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_738840_1 933262.AXAM01000073_gene3361 2.29e-97 294.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,42MIA@68525|delta/epsilon subdivisions,2WJJA@28221|Deltaproteobacteria,2MHP8@213118|Desulfobacterales 28221|Deltaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1418024_1 929556.Solca_0522 5.86e-101 310.0 COG1032@1|root,COG1032@2|Bacteria,4PHMM@976|Bacteroidetes,1IWI2@117747|Sphingobacteriia 976|Bacteroidetes C radical SAM domain protein - - - - - - - - - - - - - k59_111521_1 338963.Pcar_2435 2.83e-83 271.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WJRZ@28221|Deltaproteobacteria,43SWM@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1471490_1 1123355.JHYO01000034_gene557 6.53e-19 85.1 COG2010@1|root,COG4447@1|root,COG2010@2|Bacteria,COG4447@2|Bacteria,1NEFN@1224|Proteobacteria,2UHRQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome c - - - - - - - - - - - - - k59_1471490_2 332101.JIBU02000042_gene1480 1.54e-09 60.5 COG0398@1|root,COG0398@2|Bacteria,1TRFC@1239|Firmicutes,24CYX@186801|Clostridia,36DVI@31979|Clostridiaceae 186801|Clostridia S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_1211322_1 330214.NIDE3313 9.05e-68 232.0 COG2132@1|root,COG2132@2|Bacteria 2|Bacteria Q Multicopper oxidase - - 1.16.3.3,1.7.2.1 ko:K00368,ko:K07233,ko:K22349 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Copper-bind,Cu-oxidase_2,Cu-oxidase_3 k59_1211326_1 713586.KB900536_gene469 1.38e-34 132.0 COG0477@1|root,COG2814@2|Bacteria,1RCII@1224|Proteobacteria 1224|Proteobacteria EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_1365922_1 768066.HELO_1601 2e-84 268.0 COG3960@1|root,COG3960@2|Bacteria,1MV88@1224|Proteobacteria,1RW45@1236|Gammaproteobacteria,1XNQX@135619|Oceanospirillales 135619|Oceanospirillales S Belongs to the TPP enzyme family - - 4.1.1.47 ko:K01608 ko00630,ko01100,map00630,map01100 - R00013 RC00899 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1104972_1 1229909.NSED_06190 9.68e-72 220.0 COG1573@1|root,arCOG00905@2157|Archaea,41SJ1@651137|Thaumarchaeota 651137|Thaumarchaeota L uracil-DNA glycosylase - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_582166_1 204669.Acid345_1269 1.03e-79 251.0 COG0404@1|root,COG0404@2|Bacteria,3Y3IU@57723|Acidobacteria,2JI8G@204432|Acidobacteriia 2|Bacteria E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_793387_1 78345.BMERY_0528 1.86e-17 86.7 COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria,4CZGJ@85004|Bifidobacteriales 201174|Actinobacteria EK Alanine-glyoxylate amino-transferase - - - ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_1471522_1 105559.Nwat_0654 4.7e-09 59.7 COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,1RPY4@1236|Gammaproteobacteria,1WVV1@135613|Chromatiales 135613|Chromatiales M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1471522_2 314278.NB231_04155 9.35e-37 135.0 COG0438@1|root,COG0438@2|Bacteria,1QFQQ@1224|Proteobacteria,1RPY4@1236|Gammaproteobacteria,1WVV1@135613|Chromatiales 135613|Chromatiales M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_477763_1 1232683.ADIMK_2146 3.11e-11 66.2 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,464SD@72275|Alteromonadaceae 1236|Gammaproteobacteria O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_477763_2 331869.BAL199_15348 8.05e-79 253.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSZ8@28211|Alphaproteobacteria,4BPKK@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria EH COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase alsS - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1052645_2 1137745.H6WFR8_9CAUD 3.26e-18 77.0 4QCNS@10239|Viruses,4QXB5@35237|dsDNA viruses no RNA stage,4QRK1@28883|Caudovirales,4QJHS@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1052645_3 444859.E3SI18_9CAUD 3.29e-27 100.0 4QFJ9@10239|Viruses,4R00I@35237|dsDNA viruses no RNA stage,4QSHN@28883|Caudovirales,4QJAK@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_999437_1 436308.Nmar_0312 5.13e-61 196.0 COG0142@1|root,arCOG01726@2157|Archaea,41SEV@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the FPP GGPP synthase family - - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13787 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00365 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_999437_2 436308.Nmar_0313 3.58e-38 133.0 COG1443@1|root,arCOG01081@2157|Archaea,41T09@651137|Thaumarchaeota 651137|Thaumarchaeota I NUDIX domain - - 5.3.3.2 ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01123 RC00455 ko00000,ko00001,ko00002,ko01000 - - - NUDIX k59_738880_1 765914.ThisiDRAFT_2078 3.07e-75 244.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales 135613|Chromatiales U sulphate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_425713_1 502025.Hoch_4120 8.11e-45 157.0 COG1075@1|root,COG1075@2|Bacteria,1Q6AV@1224|Proteobacteria,432RP@68525|delta/epsilon subdivisions 1224|Proteobacteria S PGAP1-like protein - - 3.1.1.3 ko:K01046 ko00561,ko01100,map00561,map01100 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000 - - - PGAP1 k59_1211350_1 1128427.KB904821_gene441 4.26e-114 358.0 COG0474@1|root,COG0474@2|Bacteria,1G4BB@1117|Cyanobacteria,1H7WQ@1150|Oscillatoriales 1117|Cyanobacteria P Cation transporter/ATPase, N-terminus - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_1313431_1 396588.Tgr7_1071 2.95e-34 129.0 COG3396@1|root,COG3396@2|Bacteria,1NJ4Y@1224|Proteobacteria,1SGSK@1236|Gammaproteobacteria 1236|Gammaproteobacteria S P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_1627097_1 436308.Nmar_1761 5.58e-100 295.0 COG1878@1|root,arCOG02462@2157|Archaea,41SK8@651137|Thaumarchaeota 651137|Thaumarchaeota E Putative cyclase - - - - - - - - - - - - Cyclase k59_1627097_2 1229909.NSED_00895 6.78e-83 254.0 COG1180@1|root,arCOG00946@2157|Archaea,41SBZ@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Radical_SAM k59_843629_1 765913.ThidrDRAFT_0543 1.21e-31 129.0 COG1858@1|root,COG1999@1|root,COG1858@2|Bacteria,COG1999@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1X14I@135613|Chromatiales 135613|Chromatiales C PFAM Di-heme cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_62174_1 278957.ABEA03000091_gene723 1.7e-97 294.0 COG0180@1|root,COG0180@2|Bacteria,46SA6@74201|Verrucomicrobia,3K7UW@414999|Opitutae 414999|Opitutae J Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_62174_2 1162668.LFE_0188 3.43e-32 127.0 COG0115@1|root,COG0115@2|Bacteria,3J0BM@40117|Nitrospirae 40117|Nitrospirae E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_1627102_1 1122919.KB905597_gene4259 8.07e-88 263.0 COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,4H9XP@91061|Bacilli,26SGI@186822|Paenibacillaceae 91061|Bacilli EH with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine pabA - 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_738892_1 983328.AFGH01000026_gene414 2.09e-18 84.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2YNCB@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - iIT341.HP0330 IlvC,IlvN k59_738892_2 1454004.AW11_00779 2.61e-53 172.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2VH1H@28216|Betaproteobacteria,1KPXQ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E Acetolactate synthase I III small subunit ilvH GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT_5,ALS_ss_C k59_1471554_1 1054213.HMPREF9946_01325 8.33e-90 273.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,2JQ95@204441|Rhodospirillales 204441|Rhodospirillales E Methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_1471554_2 1121033.AUCF01000018_gene5781 8.42e-17 80.1 COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,2JPME@204441|Rhodospirillales 204441|Rhodospirillales KQ helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20,HTH_5,Methyltransf_11 k59_999467_1 926554.KI912616_gene4641 2.53e-53 182.0 COG0483@1|root,COG0483@2|Bacteria,1WN4P@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Inositol monophosphatase - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_999467_2 675806.VII_000833 3.73e-08 54.3 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1XT5B@135623|Vibrionales 135623|Vibrionales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_1212580_2 1177154.Y5S_01713 5.37e-14 72.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,1XI5R@135619|Oceanospirillales 135619|Oceanospirillales S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16 k59_1314325_1 1122603.ATVI01000005_gene3679 6.92e-104 315.0 COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1X35C@135614|Xanthomonadales 135614|Xanthomonadales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P k59_1472762_2 96561.Dole_2278 8.02e-24 100.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MMIR@213118|Desulfobacterales 28221|Deltaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1212590_1 263358.VAB18032_09460 9.31e-41 148.0 COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4DC1F@85008|Micromonosporales 201174|Actinobacteria C F420-0:Gamma-glutamyl ligase fbiB GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944 6.3.2.31,6.3.2.34 ko:K12234 ko00680,ko01120,map00680,map01120 M00378 R09399,R09400 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000 - - - F420_ligase,Nitroreductase k59_1000533_1 1173701.A0A066XLI5 5.6e-16 79.7 COG1228@1|root,2SKZN@2759|Eukaryota,39YRF@33154|Opisthokonta,3P1JV@4751|Fungi,3QJB2@4890|Ascomycota,2193B@147550|Sordariomycetes,1EVNH@1028384|Glomerellales 4751|Fungi G amidohydrolase - - - - - - - - - - - - Amidohydro_1 k59_1000533_2 1504981.KO116_1351 4.01e-37 131.0 COG2391@1|root,COG2391@2|Bacteria,1MZ3A@1224|Proteobacteria,1S95T@1236|Gammaproteobacteria,1XM16@135619|Oceanospirillales 135619|Oceanospirillales S transporter component - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_689653_1 1229909.NSED_01250 1.84e-110 327.0 COG0470@1|root,arCOG00470@2157|Archaea,41S9F@651137|Thaumarchaeota 651137|Thaumarchaeota L ATPase family associated with various cellular activities (AAA) - - - ko:K04800 ko03030,map03030 - - - ko00000,ko00001,ko03032 - - - AAA k59_583149_1 1121033.AUCF01000031_gene90 2.79e-51 167.0 COG2050@1|root,COG2050@2|Bacteria,1MZRJ@1224|Proteobacteria,2U9BM@28211|Alphaproteobacteria,2JTJ5@204441|Rhodospirillales 204441|Rhodospirillales Q protein, possibly involved in aromatic compounds catabolism - - - - - - - - - - - - 4HBT k59_583149_2 991905.SL003B_2830 9.76e-13 62.8 COG3313@1|root,COG3313@2|Bacteria,1Q96A@1224|Proteobacteria,2VARH@28211|Alphaproteobacteria,4BSY9@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1289) - - - ko:K06938 - - - - ko00000 - - - DUF1289 k59_583149_3 367336.OM2255_06765 2.27e-14 75.9 COG3917@1|root,COG3917@2|Bacteria,1MWB9@1224|Proteobacteria,2U07P@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q 2-hydroxychromene-2-carboxylate isomerase nahD - - - - - - - - - - - DSBA k59_583149_4 497321.C664_11455 1.95e-78 245.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,2KV1Y@206389|Rhodocyclales 206389|Rhodocyclales I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1053608_1 999141.GME_03737 6.12e-47 163.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1XIP2@135619|Oceanospirillales 135619|Oceanospirillales M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_426701_1 330214.NIDE2766 7.05e-20 83.6 COG1403@1|root,COG1403@2|Bacteria,3J0VM@40117|Nitrospirae 40117|Nitrospirae L HNH nucleases - - - - - - - - - - - - HNH_5 k59_426701_2 330214.NIDE2765 1.66e-59 187.0 COG4235@1|root,COG4235@2|Bacteria 2|Bacteria O cytochrome complex assembly cycH - 3.4.21.105 ko:K02200,ko:K04018,ko:K19225,ko:K20543,ko:K21007 ko02025,map02025 - - - ko00000,ko00001,ko01000,ko01002,ko02000 1.B.55.3 - - TPR_16,TPR_19,TPR_2,TPR_8 k59_1366926_1 1380394.JADL01000001_gene3072 1.55e-181 515.0 COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2TR20@28211|Alphaproteobacteria,2JPF7@204441|Rhodospirillales 204441|Rhodospirillales H ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity - - - ko:K06048 - - - - ko00000,ko01000 - - - GCS2 k59_530932_1 1280948.HY36_14350 6.04e-06 47.8 COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,2UBUC@28211|Alphaproteobacteria,44004@69657|Hyphomonadaceae 28211|Alphaproteobacteria MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins - - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_322828_1 1089552.KI911559_gene103 1.22e-60 198.0 COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2U8WM@28211|Alphaproteobacteria,2JZFM@204441|Rhodospirillales 204441|Rhodospirillales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_1314343_1 243231.GSU2486 1.66e-15 75.5 COG2403@1|root,COG2403@2|Bacteria,1MV4C@1224|Proteobacteria,42NE0@68525|delta/epsilon subdivisions,2WJ94@28221|Deltaproteobacteria,43TJC@69541|Desulfuromonadales 28221|Deltaproteobacteria S cyclic 2,3-diphosphoglycerate synthetase activity - - - - - - - - - - - - - k59_1314343_2 402881.Plav_0853 1.81e-84 265.0 COG2072@1|root,COG2072@2|Bacteria,1MU71@1224|Proteobacteria,2TV2E@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Flavoprotein involved in K transport MA20_07830 - - - - - - - - - - - FMO-like,NAD_binding_8 k59_322831_1 999541.bgla_2g06410 2.05e-84 260.0 COG2084@1|root,COG2084@2|Bacteria,1MUD0@1224|Proteobacteria,2VKIK@28216|Betaproteobacteria,1K0KC@119060|Burkholderiaceae 28216|Betaproteobacteria I PFAM 6-phosphogluconate dehydrogenase NAD-binding garR - 1.1.1.31,1.1.1.411 ko:K00020,ko:K08319 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_530943_1 443143.GM18_0561 9.75e-38 142.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,42P2T@68525|delta/epsilon subdivisions,2WJ9B@28221|Deltaproteobacteria,43SU2@69541|Desulfuromonadales 28221|Deltaproteobacteria J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA rsmB - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_163415_1 580332.Slit_2900 9.16e-40 147.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VHA9@28216|Betaproteobacteria,44WGE@713636|Nitrosomonadales 28216|Betaproteobacteria E Belongs to the DegT DnrJ EryC1 family - - 1.17.1.1 ko:K12452 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - DegT_DnrJ_EryC1 k59_112571_1 1121878.AUGL01000007_gene1090 1.94e-242 682.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1RMHR@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2015 Alkyl sulfatase and related hydrolases BDS1 - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_897007_1 861299.J421_0686 5.17e-42 145.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - 2.1.1.222,2.1.1.64 ko:K00568,ko:K15257 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000,ko03016 - - - Methyltransf_11,Methyltransf_23,Methyltransf_25 k59_112576_1 395963.Bind_1961 2e-71 232.0 COG0334@1|root,COG2197@1|root,COG0334@2|Bacteria,COG2197@2|Bacteria,1MUMF@1224|Proteobacteria,2TSZY@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family gdh - 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N,Response_reg k59_270095_1 187272.Mlg_2195 2.29e-20 91.7 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1WWI1@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_270095_2 105559.Nwat_0224 1.42e-108 322.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1WWBT@135613|Chromatiales 135613|Chromatiales M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_163429_1 314285.KT71_16781 4.71e-22 92.8 2AEZN@1|root,314XR@2|Bacteria,1NSHG@1224|Proteobacteria,1SMR4@1236|Gammaproteobacteria,1J84Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1314360_1 1229205.BUPH_01539 2.08e-40 152.0 COG4409@1|root,COG4409@2|Bacteria,1Q513@1224|Proteobacteria,2WB3C@28216|Betaproteobacteria,1K536@119060|Burkholderiaceae 28216|Betaproteobacteria G BNR repeat-like domain - - - - - - - - - - - - BNR,BNR_2 k59_4286_1 935863.AWZR01000013_gene1458 2.27e-29 124.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1X3AY@135614|Xanthomonadales 135614|Xanthomonadales T Chemotaxis protein histidine kinase and related kinases pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1264765_1 1049564.TevJSym_ap00510 1.06e-111 342.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1J4U3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CP CP COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit nuoL - 1.6.5.3 ko:K00341,ko:K05559 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_1479756_2 1287116.X734_09920 0.000761 47.0 COG0006@1|root,COG0006@2|Bacteria,1MWUT@1224|Proteobacteria,2TT29@28211|Alphaproteobacteria,43GYW@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Creatinase/Prolidase N-terminal domain - - 3.4.13.9 ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_1633848_1 2340.JV46_28010 6.11e-54 183.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1JC0J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Insulinase (Peptidase family M16) pqqL - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_431723_1 1002672.SAR11G3_00867 1.47e-74 231.0 COG0695@1|root,COG0695@2|Bacteria,1RC6T@1224|Proteobacteria 1224|Proteobacteria O DinB superfamily - - - - - - - - - - - - DinB_2,Glutaredoxin k59_486198_1 247490.KSU1_C0603 6.79e-22 103.0 2DV9K@1|root,33UVG@2|Bacteria 2|Bacteria S Parallel beta-helix repeats - - - - - - - - - - - - - k59_849785_1 926550.CLDAP_16780 4.95e-57 193.0 COG5598@1|root,COG5598@2|Bacteria 2|Bacteria H trimethylamine methyltransferase - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB k59_1372156_1 1530186.JQEY01000021_gene478 9.11e-18 77.8 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,2UCKH@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH,PRA-PH k59_275379_1 1333998.M2A_1689 5.44e-44 161.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,4BPAA@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_380721_1 105559.Nwat_2279 1.99e-113 354.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,1RMSH@1236|Gammaproteobacteria,1WY9K@135613|Chromatiales 135613|Chromatiales G alpha amylase catalytic - - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_328087_1 330214.NIDE0366 5.97e-41 140.0 COG1664@1|root,COG1664@2|Bacteria,3J1F5@40117|Nitrospirae 40117|Nitrospirae M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin k59_1580608_1 768679.TTX_2093 1.78e-33 127.0 COG0111@1|root,arCOG01754@2157|Archaea,2XQAR@28889|Crenarchaeota 28889|Crenarchaeota C PFAM D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_431759_1 1449351.RISW2_17555 6.88e-34 135.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2U6DG@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - DUF4214,HemolysinCabind k59_536162_2 264730.PSPPH_4578 8.14e-53 169.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,1Z7KY@136849|Pseudomonas syringae group 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_536162_3 290398.Csal_0434 1.37e-33 118.0 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,1S62N@1236|Gammaproteobacteria,1XKDP@135619|Oceanospirillales 135619|Oceanospirillales J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_70410_1 1121106.JQKB01000014_gene5655 6.96e-10 59.7 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2TQQ1@28211|Alphaproteobacteria,2JPU0@204441|Rhodospirillales 204441|Rhodospirillales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_70410_2 395493.BegalDRAFT_2551 2.16e-196 560.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,45ZVD@72273|Thiotrichales 72273|Thiotrichales E TIGRFAM Acetolactate synthase, large subunit, biosynthetic - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_275398_1 1499967.BAYZ01000096_gene4306 4.09e-31 134.0 COG3119@1|root,COG5652@1|root,COG3119@2|Bacteria,COG5652@2|Bacteria,2NRYS@2323|unclassified Bacteria 2|Bacteria P Sulfatase - - - - - - - - - - - - Cu-binding_MopE,DUF4976,Sulfatase,VanZ k59_275398_2 70448.A0A090N3Z3 5e-95 293.0 COG0626@1|root,KOG0053@2759|Eukaryota,37K09@33090|Viridiplantae,34GXJ@3041|Chlorophyta 3041|Chlorophyta E Cys/Met metabolism PLP-dependent enzyme CGS1 - 2.5.1.48 ko:K01739 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00420,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_1111238_1 40571.JOEA01000033_gene803 2.81e-45 154.0 COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4DZA5@85010|Pseudonocardiales 201174|Actinobacteria K Sir2 family cobB2 - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_328113_1 323848.Nmul_A1005 7.65e-29 108.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2VK46@28216|Betaproteobacteria,3721J@32003|Nitrosomonadales 28216|Betaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_328113_2 1123392.AQWL01000001_gene1601 8.02e-48 165.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,1KRDP@119069|Hydrogenophilales 119069|Hydrogenophilales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_1218743_2 713586.KB900536_gene1924 1.22e-28 105.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1WY7E@135613|Chromatiales 135613|Chromatiales J PFAM Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_954644_1 1125863.JAFN01000001_gene3464 1.97e-48 174.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-2 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1319240_1 1116375.VEJY3_19536 1.07e-39 142.0 COG1651@1|root,COG1651@2|Bacteria,1MX2T@1224|Proteobacteria,1SASV@1236|Gammaproteobacteria,1XW7S@135623|Vibrionales 135623|Vibrionales O DSBA-like thioredoxin domain - - - - - - - - - - - - Thioredoxin_4 k59_1524800_1 278963.ATWD01000001_gene3210 7.6e-36 138.0 COG1506@1|root,COG1506@2|Bacteria,3Y357@57723|Acidobacteria 57723|Acidobacteria E PFAM Tannase and feruloyl esterase - - - - - - - - - - - - Tannase k59_169519_1 445684.E3SQ80_9CAUD 2.91e-31 126.0 4QAZ6@10239|Viruses,4QUU8@35237|dsDNA viruses no RNA stage,4QPHV@28883|Caudovirales,4QI4H@10662|Myoviridae 10662|Myoviridae S Phage tail sheath protein - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098027 - - - - - - - - - - - k59_1524802_1 330214.NIDE4384 4.53e-07 50.8 COG0397@1|root,COG0397@2|Bacteria 2|Bacteria S Uncharacterized ACR, YdiU/UPF0061 family ydiU - - ko:K08997 - - - - ko00000 - - - UPF0061 k59_432698_1 1132836.RCCGE510_16244 2.88e-08 56.6 COG1028@1|root,COG1028@2|Bacteria,1N4J7@1224|Proteobacteria,2U6QA@28211|Alphaproteobacteria,4BM58@82115|Rhizobiaceae 28211|Alphaproteobacteria IQ Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_432698_2 62928.azo3913 2.98e-27 106.0 COG4706@1|root,COG4706@2|Bacteria,1RIH4@1224|Proteobacteria,2VT0K@28216|Betaproteobacteria,2KWT5@206389|Rhodocyclales 206389|Rhodocyclales I dehydratase - - - - - - - - - - - - - k59_1372972_1 1217714.F975_02737 7.55e-40 152.0 COG0457@1|root,COG0457@2|Bacteria,1R50I@1224|Proteobacteria,1RSP6@1236|Gammaproteobacteria,3NNTB@468|Moraxellaceae 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1319246_1 765914.ThisiDRAFT_1543 1.7e-41 144.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1WX5V@135613|Chromatiales 135613|Chromatiales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_381784_1 1206731.BAGB01000173_gene89 1.69e-65 215.0 COG2124@1|root,COG2124@2|Bacteria,2GNZS@201174|Actinobacteria,4G8MD@85025|Nocardiaceae 201174|Actinobacteria Q Cytochrome P450 - - - - - - - - - - - - p450 k59_432705_2 639282.DEFDS_0184 5.15e-15 73.9 COG0730@1|root,COG0730@2|Bacteria,2GFGY@200930|Deferribacteres 200930|Deferribacteres S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_487272_1 1151292.QEW_2996 1.29e-47 162.0 COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,247ZJ@186801|Clostridia,25QQ0@186804|Peptostreptococcaceae 186801|Clostridia T Psort location Cytoplasmic, score phoH - - ko:K06217 - - - - ko00000 - - - PhoH k59_487272_2 1211115.ALIQ01000207_gene4751 1.07e-14 74.3 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,2UBXV@28211|Alphaproteobacteria,3NBAP@45404|Beijerinckiaceae 28211|Alphaproteobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_487272_3 398767.Glov_2734 8.62e-26 112.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2WIUD@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_1059915_1 255470.cbdbA577 7.54e-20 90.5 COG0272@1|root,COG0272@2|Bacteria,2G5TK@200795|Chloroflexi,34CJG@301297|Dehalococcoidia 301297|Dehalococcoidia L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_1059915_2 1232410.KI421426_gene1373 1.3e-28 115.0 COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,42MQX@68525|delta/epsilon subdivisions,2WKUP@28221|Deltaproteobacteria,43U78@69541|Desulfuromonadales 28221|Deltaproteobacteria L DNA polymerase X family - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP k59_1480842_1 745411.B3C1_17502 2.6e-25 111.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1RMM6@1236|Gammaproteobacteria,1J4UG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_903102_2 1233950.IW22_13095 3.47e-17 82.4 COG0352@1|root,COG0352@2|Bacteria,4NNFB@976|Bacteroidetes,1I1XE@117743|Flavobacteriia,3ZPSB@59732|Chryseobacterium 976|Bacteroidetes H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin,TMP-TENI k59_381800_1 543728.Vapar_2473 2.29e-06 55.1 COG0740@1|root,COG0740@2|Bacteria,1MUQ9@1224|Proteobacteria,2VPIR@28216|Betaproteobacteria,4AEKF@80864|Comamonadaceae 28216|Betaproteobacteria OU Belongs to the peptidase S14 family - - - - - - - - - - - - CLP_protease k59_1006994_1 1121106.JQKB01000046_gene3094 3.21e-30 120.0 28MWI@1|root,2ZB3T@2|Bacteria,1RAPA@1224|Proteobacteria,2U1GH@28211|Alphaproteobacteria,2JVU6@204441|Rhodospirillales 204441|Rhodospirillales S Plasmid encoded RepA protein - - - - - - - - - - - - RepA_C k59_1634942_1 754477.Q7C_108 4.26e-47 160.0 COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,1RSGA@1236|Gammaproteobacteria,460EZ@72273|Thiotrichales 72273|Thiotrichales S Uncharacterised protein family (UPF0014) - - - ko:K02069 - M00211 - - ko00000,ko00002,ko02000 9.B.25.1 - - UPF0014 k59_487290_1 1121430.JMLG01000002_gene1268 1.6e-33 131.0 COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,260MU@186807|Peptococcaceae 186801|Clostridia C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,POR_N,TPP_enzyme_C k59_1524817_1 518766.Rmar_1064 6.31e-47 165.0 COG1914@1|root,COG1914@2|Bacteria,4NENE@976|Bacteroidetes 976|Bacteroidetes P H( )-stimulated, divalent metal cation uptake system mntH - - - - - - - - - - - Nramp k59_1006996_1 565045.NOR51B_964 2.44e-33 132.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - CHU_C,DUF11,DUF4157,PMT_2,WD40 k59_1272875_1 680198.SCAB_58021 5.81e-58 199.0 COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria 201174|Actinobacteria I carboxylase accA1 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 6.3.4.14,6.4.1.2,6.4.1.3 ko:K11263 ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv2501c Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1581467_1 319003.Bra1253DRAFT_07455 2.25e-99 313.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TQMV@28211|Alphaproteobacteria,3JSPM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G PQQ-like domain - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 k59_903111_1 1279019.ARQK01000060_gene2205 3.08e-34 122.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,1WY5S@135613|Chromatiales 135613|Chromatiales J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_903111_2 1469245.JFBG01000023_gene1250 5.95e-90 274.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1WX0N@135613|Chromatiales 135613|Chromatiales I Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_1372994_1 608538.HTH_1082 1.47e-30 117.0 COG5002@1|root,COG5002@2|Bacteria,2G40K@200783|Aquificae 200783|Aquificae T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_1372994_2 671143.DAMO_1103 1.72e-63 205.0 COG0226@1|root,COG0226@2|Bacteria,2NQMD@2323|unclassified Bacteria 2|Bacteria P PBP superfamily domain pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_589372_1 472759.Nhal_1963 1.56e-36 132.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1WWMZ@135613|Chromatiales 135613|Chromatiales E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_695847_1 314278.NB231_00345 5.77e-21 89.7 2D7FD@1|root,32TNY@2|Bacteria,1NAHU@1224|Proteobacteria,1S9DD@1236|Gammaproteobacteria,1WYZ8@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF1992) - - - - - - - - - - - - DUF1992 k59_803206_1 1279017.AQYJ01000029_gene3637 3.83e-47 157.0 2BZ6R@1|root,332GN@2|Bacteria,1P7K3@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_381836_1 96561.Dole_0563 1.95e-64 202.0 2A4CF@1|root,30SY3@2|Bacteria,1RFXP@1224|Proteobacteria,42RIM@68525|delta/epsilon subdivisions,2WNS6@28221|Deltaproteobacteria,2MNMZ@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - Yip1 k59_1480885_1 330214.NIDE4254 1.48e-74 236.0 COG0624@1|root,COG0624@2|Bacteria 2|Bacteria E succinyl-diaminopimelate desuccinylase activity - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_903123_2 331869.BAL199_06614 7.61e-15 73.2 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_850686_1 1048339.KB913029_gene2967 5.61e-27 107.0 COG1878@1|root,COG1878@2|Bacteria,2GJ59@201174|Actinobacteria,4EVXM@85013|Frankiales 201174|Actinobacteria S Putative cyclase - - - - - - - - - - - - Cyclase k59_850686_2 479433.Caci_8748 1.1e-54 181.0 COG1878@1|root,COG1878@2|Bacteria,2GJ59@201174|Actinobacteria 201174|Actinobacteria S Putative cyclase - - - - - - - - - - - - Cyclase k59_119629_1 595536.ADVE02000001_gene1232 4.38e-38 146.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,36X8N@31993|Methylocystaceae 28211|Alphaproteobacteria L DEAD/H associated lhr - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_1427240_1 1229909.NSED_02730 1.81e-61 200.0 COG0351@1|root,arCOG00020@2157|Archaea,41SA1@651137|Thaumarchaeota 651137|Thaumarchaeota H Phosphomethylpyrimidine kinase - - 2.5.1.3,2.7.1.49,2.7.4.7 ko:K21219 ko00730,ko01100,map00730,map01100 - R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko01000 - - - Phos_pyr_kin,ThiP_synth k59_223912_1 1249627.D779_2197 2.32e-52 184.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales 135613|Chromatiales O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1480894_1 472759.Nhal_0798 6.37e-82 263.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1WWN6@135613|Chromatiales 135613|Chromatiales E Extracellular solute-binding protein, family 5 - - - - - - - - - - - - SBP_bac_5 k59_1218818_3 740709.A10D4_12879 7.07e-15 72.8 COG3108@1|root,COG3108@2|Bacteria,1RICX@1224|Proteobacteria,1S6D5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S peptidase M15 - - - ko:K17733 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M15_4 k59_646140_1 1218084.BBJK01000011_gene1276 1.77e-26 105.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2VKQ0@28216|Betaproteobacteria,1K3BP@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM Transketolase central region - - 1.2.4.1 ko:K00162 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_646140_2 1235457.C404_10280 6.02e-38 137.0 COG0508@1|root,COG0508@2|Bacteria,1MVDC@1224|Proteobacteria,2VPEK@28216|Betaproteobacteria,1K0K3@119060|Burkholderiaceae 28216|Betaproteobacteria C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1225821_1 1121403.AUCV01000022_gene3527 7.53e-21 100.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MHZ1@213118|Desulfobacterales 28221|Deltaproteobacteria S Sterol-sensing domain of SREBP cleavage-activation - - - ko:K07003 - - - - ko00000 - - - MMPL k59_752113_1 631362.Thi970DRAFT_03886 5.63e-37 138.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria,1WWJG@135613|Chromatiales 135613|Chromatiales S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_1118098_1 266834.SM_b21542 7.83e-99 308.0 COG1178@1|root,COG1178@2|Bacteria,1MXZZ@1224|Proteobacteria,2TT7F@28211|Alphaproteobacteria,4BITD@82115|Rhizobiaceae 28211|Alphaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_595602_1 883078.HMPREF9695_03685 1.41e-89 277.0 COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,3JQYS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C FAD dependent oxidoreductase MA20_10295 - - ko:K13796 - - - - ko00000 - - - FAD_binding_2 k59_126954_3 243275.TDE_1013 2.36e-16 77.4 COG2703@1|root,COG2703@2|Bacteria,2J7CC@203691|Spirochaetes 203691|Spirochaetes P Hemerythrin HHE cation binding domain protein - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k59_79724_1 765420.OSCT_2028 1.94e-36 142.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G7K6@200795|Chloroflexi,374W8@32061|Chloroflexia 32061|Chloroflexia G SMART alpha amylase, catalytic sub domain - - 3.2.1.1,3.2.1.20,5.4.99.16 ko:K01187,ko:K05343 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R01557,R02108,R02112,R06087,R06088,R11262 RC00028,RC00049,RC00077,RC01816 ko00000,ko00001,ko01000 - GH13,GH31 - Alpha-amylase,Malt_amylase_C k59_335056_1 519989.ECTPHS_05430 2.41e-138 406.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WWEY@135613|Chromatiales 135613|Chromatiales C FAD linked oxidase - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_595614_1 1121918.ARWE01000001_gene524 1.52e-63 217.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,43UAW@69541|Desulfuromonadales 28221|Deltaproteobacteria P Cation transporter/ATPase, N-terminus - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_858195_1 530564.Psta_2260 9.69e-49 171.0 COG0541@1|root,COG0541@2|Bacteria,2IXSC@203682|Planctomycetes 203682|Planctomycetes U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_1379904_1 395965.Msil_1894 1.49e-46 168.0 COG1262@1|root,COG4249@1|root,COG1262@2|Bacteria,COG4249@2|Bacteria,1NQ5K@1224|Proteobacteria,2U2VJ@28211|Alphaproteobacteria,3NC46@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase,Peptidase_C14 k59_655868_1 378806.STAUR_1160 2.35e-52 172.0 COG0625@1|root,COG0625@2|Bacteria,1REDI@1224|Proteobacteria 1224|Proteobacteria O Belongs to the GST superfamily gstA1 - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_1119232_1 296591.Bpro_3196 5.21e-100 302.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,4ADVR@80864|Comamonadaceae 28216|Betaproteobacteria L Winged helix-turn helix - - - - - - - - - - - - DDE_3,HTH_32 k59_1282912_1 78898.MVEG_02603T0 5.47e-69 225.0 COG0129@1|root,KOG2448@2759|Eukaryota,38F28@33154|Opisthokonta,3NUBR@4751|Fungi,1GS3V@112252|Fungi incertae sedis 4751|Fungi E Dehydratase family ILV3 GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006549,GO:0006551,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_1282912_2 710685.MycrhN_2839 2.59e-17 81.6 COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria,237RH@1762|Mycobacteriaceae 201174|Actinobacteria S Oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_1379911_1 515622.bpr_I2522 1.98e-31 124.0 COG0438@1|root,COG0438@2|Bacteria,1V12E@1239|Firmicutes,24EB7@186801|Clostridia,4BY7B@830|Butyrivibrio 186801|Clostridia M Glycosyltransferase family 17 - - 2.4.1.144 ko:K00737 ko00510,ko01100,map00510,map01100 M00075 R05986 - ko00000,ko00001,ko00002,ko01000,ko01003 - GT17 - Glyco_transf_17,Glycos_transf_2 k59_497063_1 395493.BegalDRAFT_2710 1.17e-67 222.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,460AF@72273|Thiotrichales 72273|Thiotrichales E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_1227392_1 909663.KI867149_gene3455 1.48e-45 167.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MR7V@213462|Syntrophobacterales 28221|Deltaproteobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_703127_1 1415780.JPOG01000001_gene752 1.81e-38 145.0 COG3103@1|root,COG3103@2|Bacteria,1QNM4@1224|Proteobacteria,1SHYN@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Sh3 type 3 domain protein - - - - - - - - - - - - - k59_1589013_1 1094980.Mpsy_0782 5.09e-66 213.0 COG0598@1|root,arCOG02265@2157|Archaea,2XTRP@28890|Euryarchaeota,2N9K8@224756|Methanomicrobia 224756|Methanomicrobia P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_441169_1 1458357.BG58_40570 7.16e-22 92.8 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VNFE@28216|Betaproteobacteria,1K4BH@119060|Burkholderiaceae 28216|Betaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - - - - - - - - - - - ECH_1 k59_441169_2 1123269.NX02_02610 1.83e-21 90.9 COG1011@1|root,COG1011@2|Bacteria,1MU1H@1224|Proteobacteria,2TQVC@28211|Alphaproteobacteria,2K3WH@204457|Sphingomonadales 204457|Sphingomonadales S Haloacid dehalogenase - - 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase k59_230952_1 1041147.AUFB01000009_gene1869 1.81e-14 71.6 2EU9D@1|root,33MRT@2|Bacteria,1NCDT@1224|Proteobacteria,2V57U@28211|Alphaproteobacteria,4BKT8@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_812992_2 1197951.I6S295_9CAUD 1.15e-37 128.0 4QCEX@10239|Viruses,4QV7Q@35237|dsDNA viruses no RNA stage,4QU8B@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1014482_1 382464.ABSI01000010_gene3668 5.95e-85 268.0 COG0843@1|root,COG0843@2|Bacteria,46S4Q@74201|Verrucomicrobia,2ITKY@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 k59_175370_1 748247.AZKH_1766 6.05e-05 45.4 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2VIAA@28216|Betaproteobacteria,2KVDJ@206389|Rhodocyclales 206389|Rhodocyclales M HlyD membrane-fusion protein of T1SS - - - ko:K02022 - - - - ko00000 - - - HlyD_3 k59_175370_2 592316.Pat9b_2799 5.19e-15 73.6 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,1S3R2@1236|Gammaproteobacteria,3VZQW@53335|Pantoea 1236|Gammaproteobacteria O once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015232,GO:0015886,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019897,GO:0019898,GO:0022857,GO:0031224,GO:0031234,GO:0032991,GO:0042623,GO:0043190,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:1901678,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - iAPECO1_1312.APECO1_4358,iECED1_1282.ECED1_2666,iECS88_1305.ECS88_2348,iECUMN_1333.ECUMN_2536,iLF82_1304.LF82_0273,iNRG857_1313.NRG857_11170,iUMN146_1321.UM146_05800,iUTI89_1310.UTI89_C2479 ABC_tran k59_858222_2 641107.CDLVIII_5631 1.06e-21 90.1 COG3436@1|root,COG3436@2|Bacteria,1V7U9@1239|Firmicutes,24ITC@186801|Clostridia,36MEJ@31979|Clostridiaceae 186801|Clostridia L IS66 Orf2 like - - - - - - - - - - - - TnpB_IS66 k59_858222_3 156889.Mmc1_2630 3.39e-39 146.0 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,2TW7V@28211|Alphaproteobacteria 28211|Alphaproteobacteria L PFAM transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_596757_1 264198.Reut_B4843 8.15e-74 236.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VJNE@28216|Betaproteobacteria,1K4Q9@119060|Burkholderiaceae 28216|Betaproteobacteria C Aconitase family (aconitate hydratase) leuC1 - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_128437_1 1415780.JPOG01000001_gene2508 5.83e-55 192.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria,1SMN0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1014506_1 379066.GAU_1936 3.44e-158 460.0 COG2987@1|root,COG2987@2|Bacteria,1ZSQX@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N k59_1067379_2 1121918.ARWE01000001_gene3118 6.31e-54 177.0 COG0586@1|root,COG0586@2|Bacteria,1R5SJ@1224|Proteobacteria,43AE6@68525|delta/epsilon subdivisions,2X6A8@28221|Deltaproteobacteria 28221|Deltaproteobacteria S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_1643732_2 1313172.YM304_34610 2.56e-23 90.5 COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria 201174|Actinobacteria K Cold shock protein - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_175392_1 1304275.C41B8_00320 5.08e-74 228.0 COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis rnt GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - ko:K03683 - - - - ko00000,ko01000,ko03016 - - - RNase_T k59_1490603_1 244581.IM40_01270 7.7e-40 148.0 COG2860@1|root,COG2860@2|Bacteria,1QVY0@1224|Proteobacteria,2UB1W@28211|Alphaproteobacteria,47F2R@766|Rickettsiales 766|Rickettsiales S Bacterial extracellular solute-binding proteins, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3,UPF0126 k59_1282981_1 314282.PCNPT3_00385 1.08e-32 123.0 COG3264@1|root,COG3264@2|Bacteria,1QUBW@1224|Proteobacteria,1T1SF@1236|Gammaproteobacteria 1236|Gammaproteobacteria M mechanosensitive ion channel mscS - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix k59_1282981_2 225849.swp_3091 2.36e-06 48.5 COG3764@1|root,COG3764@2|Bacteria,1P806@1224|Proteobacteria,1S9RI@1236|Gammaproteobacteria,2QC05@267890|Shewanellaceae 1236|Gammaproteobacteria M PFAM peptidase C60, sortase A and B srtA - 3.4.22.70 ko:K07284 - - - - ko00000,ko01000,ko01002,ko01011 - - - Sortase k59_961679_1 268746.Q58MP1_BPPRM 4.97e-56 198.0 4QEE7@10239|Viruses,4QV59@35237|dsDNA viruses no RNA stage,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae 10662|Myoviridae S Pfam:DUF4815 - - - - - - - - - - - - - k59_128455_1 565045.NOR51B_794 1.21e-29 111.0 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,1S60F@1236|Gammaproteobacteria,1J6M3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S aspartyl protease orf - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_128455_2 640081.Dsui_2901 1.47e-55 182.0 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2VHSU@28216|Betaproteobacteria,2KVHJ@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_1014511_1 706587.Desti_1502 3.27e-14 73.6 COG2202@1|root,COG2203@1|root,COG4251@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,43C58@68525|delta/epsilon subdivisions,2X7FM@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sensor histidine kinase, PAS, PAS, PAS and PAS domain-containing - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_9 k59_1014511_2 1198114.AciX9_1820 6.21e-21 96.7 COG0682@1|root,COG0682@2|Bacteria,3Y4QQ@57723|Acidobacteria,2JJ7E@204432|Acidobacteriia 204432|Acidobacteriia M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_858260_1 997346.HMPREF9374_2337 1.12e-71 229.0 COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,4HB33@91061|Bacilli,27B02@186824|Thermoactinomycetaceae 91061|Bacilli H S-adenosylmethionine synthetase, C-terminal domain metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_441231_1 1123261.AXDW01000002_gene1501 2.14e-61 206.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1S1T4@1236|Gammaproteobacteria,1XCD5@135614|Xanthomonadales 135614|Xanthomonadales KLT Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - Pkinase,cNMP_binding k59_1067402_2 1410616.JHXE01000021_gene2335 2.24e-06 52.0 COG0110@1|root,COG1035@1|root,COG0110@2|Bacteria,COG1035@2|Bacteria,1TQGA@1239|Firmicutes,249BE@186801|Clostridia,3NI9I@46205|Pseudobutyrivibrio 186801|Clostridia C Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus - - - - - - - - - - - - Fer4,Fer4_4,Fer4_7,FrhB_FdhB_C,FrhB_FdhB_N,Hexapep,PS_pyruv_trans k59_1282999_1 1122915.AUGY01000055_gene543 1.87e-08 60.8 COG1234@1|root,COG1234@2|Bacteria,1TXG9@1239|Firmicutes,4HKX2@91061|Bacilli,26SKX@186822|Paenibacillaceae 91061|Bacilli S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B_2 k59_543993_1 1089552.KI911559_gene2018 2.58e-99 299.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2JV4G@204441|Rhodospirillales 204441|Rhodospirillales L HTH-like domain - - - - - - - - - - - - HTH_21,rve_3 k59_390289_1 1049564.TevJSym_bc00260 2.9e-79 254.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate yfcX - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1227495_1 436308.Nmar_0082 8.28e-90 273.0 COG2073@1|root,arCOG00651@2157|Archaea,41S83@651137|Thaumarchaeota 651137|Thaumarchaeota H Cobalamin synthesis G C-terminus - - 3.7.1.12 ko:K02189 ko00860,ko01100,map00860,map01100 - R07772 RC01545,RC02097 ko00000,ko00001,ko01000 - - - CbiG_C,CbiG_N,CbiG_mid k59_1119312_2 379066.GAU_2513 6e-09 61.2 COG3391@1|root,COG3391@2|Bacteria,1ZT90@142182|Gemmatimonadetes 142182|Gemmatimonadetes S amine dehydrogenase activity - - - - - - - - - - - - - k59_1067411_1 1026882.MAMP_02787 2.11e-57 184.0 COG3784@1|root,COG3784@2|Bacteria,1MYIH@1224|Proteobacteria,1S8D2@1236|Gammaproteobacteria,462EF@72273|Thiotrichales 72273|Thiotrichales S Protein of unknown function (DUF1318) - - - - - - - - - - - - DUF1318 k59_1283030_1 1283300.ATXB01000001_gene1101 1.61e-63 199.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1XF14@135618|Methylococcales 135618|Methylococcales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions - - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_813092_2 1123024.AUII01000009_gene1957 9.51e-27 108.0 COG2141@1|root,COG2141@2|Bacteria,2GNE9@201174|Actinobacteria,4EBQN@85010|Pseudonocardiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_128500_1 296591.Bpro_2805 8.48e-68 229.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,4AAQA@80864|Comamonadaceae 28216|Betaproteobacteria C formate dehydrogenase, alpha subunit fdhA1 - 1.17.1.9,1.17.99.7 ko:K00123,ko:K22015 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_128500_2 754476.Q7A_902 3.62e-73 235.0 COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,45ZR6@72273|Thiotrichales 72273|Thiotrichales C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region - - 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_497191_1 204773.HEAR1728 2.56e-39 146.0 COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,2W9TA@28216|Betaproteobacteria,477I0@75682|Oxalobacteraceae 28216|Betaproteobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_175428_2 243233.MCA1123 5.94e-11 67.4 COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1XEQ0@135618|Methylococcales 135618|Methylococcales NU type II III secretion system - - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_1490665_2 420324.KI911970_gene1454 6.15e-11 62.0 28IR7@1|root,2Z8QR@2|Bacteria,1PBTP@1224|Proteobacteria,2U248@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_336259_2 243231.GSU1820 5.54e-36 141.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,43SYQ@69541|Desulfuromonadales 28221|Deltaproteobacteria H Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 k59_596822_1 228410.NE2315 3.57e-10 62.0 COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,2VN9T@28216|Betaproteobacteria,372ZR@32003|Nitrosomonadales 28216|Betaproteobacteria NU PFAM Fimbrial assembly pilN - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_825583_1 765914.ThisiDRAFT_1553 3.23e-40 152.0 COG0834@1|root,COG4623@1|root,COG0834@2|Bacteria,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1WXYV@135613|Chromatiales 135613|Chromatiales M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella - - - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_1239007_1 1121904.ARBP01000001_gene5738 7.46e-24 99.8 COG2215@1|root,COG2215@2|Bacteria,4NS47@976|Bacteroidetes,47SDE@768503|Cytophagia 976|Bacteroidetes S Belongs to the NiCoT transporter (TC 2.A.52) family - - - - - - - - - - - - DsbD_2 k59_1537975_1 999141.GME_02079 9.21e-36 135.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1XHE1@135619|Oceanospirillales 135619|Oceanospirillales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_1537975_2 1449126.JQKL01000003_gene1740 3.03e-06 50.1 COG1619@1|root,COG1619@2|Bacteria,1TRBB@1239|Firmicutes,24ABA@186801|Clostridia,268UA@186813|unclassified Clostridiales 186801|Clostridia V LD-carboxypeptidase - - 3.4.17.13 ko:K01297 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S66 k59_1176474_1 671143.DAMO_2534 4.54e-182 548.0 COG1197@1|root,COG1197@2|Bacteria,2NNMM@2323|unclassified Bacteria 2|Bacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1446708_1 216594.MMAR_3154 3.29e-40 148.0 COG2124@1|root,COG2124@2|Bacteria,2I2QQ@201174|Actinobacteria,236UT@1762|Mycobacteriaceae 201174|Actinobacteria Q cytochrome P450 - - - - - - - - - - - - p450 k59_183118_2 1121121.KB894287_gene3403 9.37e-52 173.0 COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,4HAPT@91061|Bacilli,26TDJ@186822|Paenibacillaceae 91061|Bacilli G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_1656313_1 456442.Mboo_0258 1.04e-48 165.0 COG2518@1|root,arCOG00976@2157|Archaea,2XTRM@28890|Euryarchaeota,2N9U4@224756|Methanomicrobia 224756|Methanomicrobia J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_1295441_1 323261.Noc_0053 3.62e-20 94.7 COG0305@1|root,COG0305@2|Bacteria,1QWI1@1224|Proteobacteria,1RZ7K@1236|Gammaproteobacteria,1X1UJ@135613|Chromatiales 135613|Chromatiales L Toprim-like - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - DnaB_C k59_346585_1 330214.NIDE3286 1.43e-102 304.0 COG0341@1|root,COG0341@2|Bacteria,3J0GM@40117|Nitrospirae 40117|Nitrospirae U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_605242_1 1123072.AUDH01000001_gene3066 1.93e-07 52.0 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2U99J@28211|Alphaproteobacteria,2JSN0@204441|Rhodospirillales 204441|Rhodospirillales O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE - - ko:K02197 - - - - ko00000 - - - CcmE k59_605242_2 420662.Mpe_A1211 6e-48 171.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,1KIYF@119065|unclassified Burkholderiales 28216|Betaproteobacteria O cytochrome C ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_970754_1 330214.NIDE0561 3.26e-103 311.0 COG0535@1|root,COG0535@2|Bacteria,3J10V@40117|Nitrospirae 40117|Nitrospirae C Iron-sulfur cluster-binding domain - - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM k59_346591_1 231434.JQJH01000021_gene1639 4.11e-86 273.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,3N9KJ@45404|Beijerinckiaceae 28211|Alphaproteobacteria T Sigma-54 interaction domain hoxA - - ko:K19641 ko02020,map02020 M00772 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_240126_1 1286171.EAL2_c08490 4.69e-19 89.4 COG0095@1|root,COG0095@2|Bacteria,1TQ5U@1239|Firmicutes,247S9@186801|Clostridia 186801|Clostridia H Lipoate-protein ligase lipM - 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB,Lip_prot_lig_C k59_1656344_1 1384056.N787_09795 1.7e-26 103.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1X4UT@135614|Xanthomonadales 135614|Xanthomonadales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_1656344_2 180332.JTGN01000001_gene5012 4.46e-37 136.0 COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,248ED@186801|Clostridia 186801|Clostridia J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_183138_1 1123279.ATUS01000001_gene1824 5.17e-27 114.0 COG1388@1|root,COG3209@1|root,COG1388@2|Bacteria,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1J6H5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M silverDB - - - - - - - - - - - - DUF11,DUF2235,RHS,RHS_repeat k59_240134_1 1266914.ATUK01000018_gene736 1.4e-67 218.0 COG3547@1|root,COG3547@2|Bacteria,1RBIF@1224|Proteobacteria,1SDAR@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_921669_1 50960.LS81_05340 2.72e-18 84.7 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2YMJV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_921669_2 1123501.KB902299_gene3689 6.73e-10 62.0 COG1652@1|root,COG1652@2|Bacteria,1MWMR@1224|Proteobacteria,2U7UH@28211|Alphaproteobacteria 28211|Alphaproteobacteria M protein containing LysM domain lysM - - - - - - - - - - - LysM k59_183142_1 400682.PAC_15708554 2.93e-42 147.0 COG1028@1|root,KOG0725@2759|Eukaryota,3A1CJ@33154|Opisthokonta,3BPS9@33208|Metazoa 33208|Metazoa IQ Enoyl- acyl-carrier-protein reductase NADH - - - - - - - - - - - - adh_short_C2 k59_761986_1 1469557.JSWF01000012_gene1147 7.19e-12 66.2 COG1235@1|root,COG1235@2|Bacteria,4NM16@976|Bacteroidetes,1I9UW@117743|Flavobacteriia 976|Bacteroidetes S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_761986_2 1379270.AUXF01000007_gene1074 5.25e-20 89.4 COG1462@1|root,COG1462@2|Bacteria,1ZUR1@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Curli production assembly/transport component CsgG - - - - - - - - - - - - CsgG k59_712194_1 614083.AWQR01000017_gene2254 9.55e-11 63.2 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria,4ADJ3@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM VacJ family lipoprotein vacJ - - ko:K04754 - - - - ko00000 - - - MlaA k59_712194_2 228410.NE0331 2.24e-43 150.0 COG2854@1|root,COG2854@2|Bacteria,1N275@1224|Proteobacteria,2WBHZ@28216|Betaproteobacteria,3735V@32003|Nitrosomonadales 28216|Betaproteobacteria Q MlaC protein - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_294599_1 445684.E3SQ94_9CAUD 1.01e-86 271.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae 10662|Myoviridae S Type III restriction enzyme, res subunit - - - - - - - - - - - - - k59_509723_1 1380380.JIAX01000008_gene1844 4.05e-46 159.0 COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,2TWKE@28211|Alphaproteobacteria 28211|Alphaproteobacteria E reductase - - - - - - - - - - - - MTHFR k59_452871_1 1116232.AHBF01000072_gene9280 2.43e-60 200.0 COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria 201174|Actinobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase k59_761991_1 1463855.JOHV01000003_gene2226 1.09e-35 139.0 COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria 201174|Actinobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_1295505_1 1121918.ARWE01000001_gene285 0.000349 48.5 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria,43T8B@69541|Desulfuromonadales 28221|Deltaproteobacteria C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region nuoG-1 - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iAF987.Gmet_3349 Fer2_4,Fer4_10,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1239083_1 945713.IALB_1123 1.39e-16 81.3 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_25 k59_93274_1 406124.ACPC01000019_gene3069 1.79e-07 53.9 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,4H9S7@91061|Bacilli,1ZB6Y@1386|Bacillus 91061|Bacilli L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A k59_93274_3 331869.BAL199_18731 9.8e-11 60.5 COG3108@1|root,COG3108@2|Bacteria,1N1HE@1224|Proteobacteria,2UFZF@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Peptidase M15A - - - ko:K03791 - - - - ko00000 - GH19 - Peptidase_M15_3 k59_970802_1 1123360.thalar_02888 5.91e-104 319.0 COG1145@1|root,COG1290@1|root,COG1908@1|root,COG1145@2|Bacteria,COG1290@2|Bacteria,COG1908@2|Bacteria,1QSPU@1224|Proteobacteria,2UQID@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - Cytochrome_B,FlpD k59_1078249_1 1382356.JQMP01000004_gene54 4.84e-97 298.0 COG1622@1|root,COG1622@2|Bacteria,2G6C0@200795|Chloroflexi,27XKX@189775|Thermomicrobia 189775|Thermomicrobia C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrom_C k59_1078249_2 1379270.AUXF01000002_gene1826 5.03e-91 286.0 COG0843@1|root,COG0843@2|Bacteria,1ZSMG@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_605284_1 926569.ANT_05360 4.18e-21 96.7 COG1243@1|root,COG1243@2|Bacteria,2G5ZZ@200795|Chloroflexi 200795|Chloroflexi BK Radical_SAM C-terminal domain - - 2.3.1.48 ko:K07739 - - - - ko00000,ko01000,ko03016,ko03036 - - - Acetyltransf_1,Radical_SAM,Radical_SAM_C k59_712225_1 1288494.EBAPG3_12710 3.26e-53 179.0 COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2WAY9@28216|Betaproteobacteria,371NX@32003|Nitrosomonadales 28216|Betaproteobacteria O Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_1023358_1 330214.NIDE0352 6.12e-50 179.0 COG0308@1|root,COG0308@2|Bacteria,3J0Y4@40117|Nitrospirae 40117|Nitrospirae E Peptidase family M1 domain - - - ko:K08776 - - - - ko00000,ko01000,ko01002 - - - ERAP1_C,Peptidase_M1 k59_509761_1 635013.TherJR_1095 2.45e-33 135.0 COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,26187@186807|Peptococcaceae 186801|Clostridia E PFAM Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_921727_1 1089553.Tph_c05330 1.87e-88 271.0 COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,25E5A@186801|Clostridia,42EY9@68295|Thermoanaerobacterales 186801|Clostridia M TIGRFAM UTP--glucose-1-phosphate uridylyltransferase galU - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_139860_1 1200567.JNKD01000055_gene1796 2.53e-06 51.6 COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,1SFR6@1236|Gammaproteobacteria 1236|Gammaproteobacteria F PFAM CMP dCMP deaminase zinc-binding - - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_14994_1 1454004.AW11_02016 7.08e-05 46.6 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2VJDX@28216|Betaproteobacteria 28216|Betaproteobacteria G trehalohydrolase treZ - 3.2.1.141 ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3459 k59_14994_2 643562.Daes_2703 7.26e-89 266.0 COG2940@1|root,COG2940@2|Bacteria,1QAQZ@1224|Proteobacteria,43EC9@68525|delta/epsilon subdivisions,2X0BC@28221|Deltaproteobacteria,2MBPB@213115|Desulfovibrionales 28221|Deltaproteobacteria S SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain - - - ko:K07117 - - - - ko00000 - - - SET k59_1656426_1 867845.KI911784_gene3689 3.58e-83 257.0 COG0409@1|root,COG0409@2|Bacteria,2G5MS@200795|Chloroflexi,376PX@32061|Chloroflexia 32061|Chloroflexia O TIGRFAM hydrogenase expression formation protein HypD - - - ko:K04654 - - - - ko00000 - - - HypD k59_398231_1 411902.CLOBOL_00366 5.65e-62 209.0 COG4690@1|root,COG4690@2|Bacteria,1V44V@1239|Firmicutes 1239|Firmicutes E Peptidase family C69 - - - ko:K14358 - - - - ko00000,ko01002 - - - Peptidase_C69 k59_1388195_1 314345.SPV1_04488 2.08e-05 53.5 COG2010@1|root,COG2010@2|Bacteria,1RDNN@1224|Proteobacteria 1224|Proteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_C554 k59_240182_1 797303.Natpe_1296 0.000643 44.3 COG3119@1|root,arCOG02787@2157|Archaea,2XUWX@28890|Euryarchaeota,23S64@183963|Halobacteria 183963|Halobacteria P COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - Sulfatase k59_240182_2 338966.Ppro_2579 0.000262 45.1 2ANJH@1|root,31DIJ@2|Bacteria,1P4XW@1224|Proteobacteria 1224|Proteobacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_1295562_1 1123368.AUIS01000007_gene2819 2.99e-129 375.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,2NCEM@225057|Acidithiobacillales 1236|Gammaproteobacteria BQ Histone deacetylase domain - - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl k59_1332773_1 1123253.AUBD01000010_gene2095 3.34e-06 55.1 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1X5CR@135614|Xanthomonadales 135614|Xanthomonadales NT chemotaxis protein pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_670485_1 985867.AEWF01000001_gene2142 6.66e-33 127.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria,47F65@766|Rickettsiales 766|Rickettsiales M COG0739 Membrane proteins related to metalloendopeptidases nlpD2 - - - - - - - - - - - Peptidase_M23 k59_511687_2 472759.Nhal_2564 9.75e-57 182.0 COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,1S9CQ@1236|Gammaproteobacteria,1WZ4Y@135613|Chromatiales 135613|Chromatiales S Protein of unknown function, DUF - - - - - - - - - - - - DUF411 k59_1080042_1 314278.NB231_16933 4.61e-07 52.0 COG2930@1|root,COG2930@2|Bacteria,1RCYH@1224|Proteobacteria,1S41U@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Las17-binding protein actin regulator CT2216 - - - - - - - - - - - Ysc84 k59_1080042_2 1245469.S58_30880 3.57e-169 488.0 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1PR9I@1224|Proteobacteria,2U1SM@28211|Alphaproteobacteria 28211|Alphaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_4,Fer4_6,Pyr_redox_3 k59_1539271_1 330214.NIDE1636 3.22e-90 278.0 COG4099@1|root,COG4099@2|Bacteria 2|Bacteria F phospholipase Carboxylesterase - - - - - - - - - - - - Abhydrolase_2,Abhydrolase_8,DLH,Esterase,Peptidase_S9 k59_348556_1 649638.Trad_0374 7.37e-90 276.0 KOG2524@1|root,2ZJ84@2|Bacteria 2|Bacteria S Potential Queuosine, Q, salvage protein family - - - - - - - - - - - - Q_salvage k59_1240548_1 745014.OMB55_00011410 2.54e-71 240.0 COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,1RZK1@1236|Gammaproteobacteria 1236|Gammaproteobacteria G K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - - - - - - - - - - Sortilin-Vps10 k59_1024640_1 701176.VIBRN418_17643 6.73e-07 51.2 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RNPX@1236|Gammaproteobacteria,1XUN0@135623|Vibrionales 135623|Vibrionales P Belongs to the ABC transporter superfamily fbpC - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 k59_1024640_2 330214.NIDE1035 2.09e-43 155.0 COG1178@1|root,COG1178@2|Bacteria 2|Bacteria P thiamine transport sfuB - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_1658372_2 309807.SRU_0691 3.37e-31 126.0 COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,4NFGR@976|Bacteroidetes,1FIND@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E homoserine dehydrogenase - - 1.1.1.3,2.7.2.4 ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT_7,Homoserine_dh,NAD_binding_3 k59_713681_1 701347.Entcl_0859 2.75e-50 171.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,3X19W@547|Enterobacter 1236|Gammaproteobacteria D TIGRFAM Tyrosine recombinase XerD xerD GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_670499_1 1096546.WYO_2175 1.76e-23 103.0 COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,2TTHW@28211|Alphaproteobacteria,1JQZS@119045|Methylobacteriaceae 28211|Alphaproteobacteria G PFAM major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_1 k59_241602_1 1033810.HLPCO_000206 2.74e-13 69.3 COG0667@1|root,COG0667@2|Bacteria,2NPI2@2323|unclassified Bacteria 2|Bacteria C Aldo/keto reductase family tas - - - - - - - - - - - Aldo_ket_red k59_1246261_1 1202532.FF52_20647 1.68e-31 125.0 COG3119@1|root,COG3119@2|Bacteria,4NEPB@976|Bacteroidetes,1HYHN@117743|Flavobacteriia,2NVGY@237|Flavobacterium 976|Bacteroidetes P Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Sulfatase k59_1339404_1 330214.NIDE3251 5.5e-138 424.0 COG3696@1|root,COG3696@2|Bacteria 2|Bacteria P silver ion transport - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_190375_1 742733.HMPREF9469_03001 7.11e-45 167.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,21Z2D@1506553|Lachnoclostridium 186801|Clostridia KT Propionate catabolism activator - - - ko:K02688 - - - - ko00000,ko03000 - - - PAS_8,PrpR_N,Sigma54_activat k59_520482_2 521045.Kole_1899 1.05e-65 208.0 COG0090@1|root,COG0090@2|Bacteria,2GBXA@200918|Thermotogae 200918|Thermotogae J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_147057_2 1123240.ATVO01000006_gene1477 1.94e-31 119.0 COG2141@1|root,COG2141@2|Bacteria,1MWMV@1224|Proteobacteria,2TTIQ@28211|Alphaproteobacteria,2K0FP@204457|Sphingomonadales 204457|Sphingomonadales C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - 1.14.14.5 ko:K04091 ko00920,map00920 - R07210,R10206 RC01779,RC02556 ko00000,ko00001,ko01000 - - - Bac_luciferase k59_460316_1 399795.CtesDRAFT_PD2768 6.73e-11 68.9 COG1012@1|root,COG1012@2|Bacteria,1R656@1224|Proteobacteria,2VPB8@28216|Betaproteobacteria,4ACVM@80864|Comamonadaceae 28216|Betaproteobacteria C Acyl-CoA reductase (LuxC) - - - - - - - - - - - - LuxC k59_874495_1 666681.M301_2428 3.21e-47 169.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2VIZM@28216|Betaproteobacteria,2KM24@206350|Nitrosomonadales 206350|Nitrosomonadales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_560871_1 1031288.AXAA01000005_gene2030 2.83e-34 130.0 COG0031@1|root,COG0031@2|Bacteria,1UI2J@1239|Firmicutes,25EB5@186801|Clostridia,36UJ3@31979|Clostridiaceae 186801|Clostridia E Pyridoxal-phosphate dependent enzyme - - 2.3.1.263 ko:K21400 - - - - ko00000,ko01000 - - - PALP k59_560871_2 546275.FUSPEROL_00288 7.09e-13 65.1 2E6IF@1|root,3315M@2|Bacteria,37C42@32066|Fusobacteria 32066|Fusobacteria - - - - 2.3.1.263 ko:K21399 - - - - ko00000,ko01000 - - - - k59_520496_1 595537.Varpa_2326 1.61e-71 226.0 COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2VJ5B@28216|Betaproteobacteria,4AC0Y@80864|Comamonadaceae 28216|Betaproteobacteria S 2-nitropropane dioxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_1086472_1 1123261.AXDW01000002_gene1602 5.61e-71 236.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1X3EQ@135614|Xanthomonadales 135614|Xanthomonadales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt k59_247933_1 857087.Metme_1539 1.59e-29 120.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RQW8@1236|Gammaproteobacteria,1XGZI@135618|Methylococcales 135618|Methylococcales M Protein of unknown function (DUF3772) - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - DUF3772,MS_channel k59_1030979_1 744872.Spica_0170 7.97e-45 160.0 COG0351@1|root,COG0351@2|Bacteria,2J67Q@203691|Spirochaetes 203691|Spirochaetes H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_1545340_2 589865.DaAHT2_0798 2.35e-18 85.5 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,42M7V@68525|delta/epsilon subdivisions,2WIUB@28221|Deltaproteobacteria,2MIV4@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_101670_1 1132855.KB913035_gene1498 5.82e-59 197.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2VHFX@28216|Betaproteobacteria,2KKTT@206350|Nitrosomonadales 206350|Nitrosomonadales J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_1667334_1 1411123.JQNH01000001_gene744 8.42e-70 222.0 COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,2TVMD@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the carbamate kinase family arcC - 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase k59_303041_1 1282876.BAOK01000002_gene892 1.17e-57 194.0 COG0477@1|root,COG0477@2|Bacteria,1R02N@1224|Proteobacteria,2TYHV@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_147123_1 1198114.AciX9_2143 1.92e-67 228.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,3Y2RB@57723|Acidobacteria,2JIRW@204432|Acidobacteriia 204432|Acidobacteriia I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1,ECH_2 k59_101703_1 1123367.C666_01815 5.27e-34 129.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,2KU74@206389|Rhodocyclales 206389|Rhodocyclales O Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_101703_2 1454004.AW11_02064 7.31e-06 49.3 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2VJN0@28216|Betaproteobacteria,1KQJ0@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_1394838_1 335543.Sfum_4053 1.08e-77 247.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WJ0U@28221|Deltaproteobacteria,2MQ46@213462|Syntrophobacterales 28221|Deltaproteobacteria E PFAM Aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 k59_1394838_2 1196323.ALKF01000189_gene1174 2.04e-31 118.0 COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,4HBXZ@91061|Bacilli,26RHP@186822|Paenibacillaceae 91061|Bacilli D Necessary for normal cell division and for the maintenance of normal septation engB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_520591_1 1229909.NSED_01515 2.03e-100 295.0 COG1608@1|root,arCOG00860@2157|Archaea,41SI4@651137|Thaumarchaeota 651137|Thaumarchaeota I Amino acid kinase family - - 2.7.4.26 ko:K06981 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R10093 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_147133_1 436308.Nmar_1262 3.74e-119 348.0 COG0206@1|root,arCOG02201@2157|Archaea,41SG8@651137|Thaumarchaeota 651137|Thaumarchaeota D Tubulin/FtsZ family, GTPase domain - - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - Tubulin k59_190476_1 714943.Mucpa_2436 1.35e-63 210.0 COG2192@1|root,COG2192@2|Bacteria,4NEV9@976|Bacteroidetes,1IP8X@117747|Sphingobacteriia 976|Bacteroidetes O PFAM Carbamoyltransferase - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_101723_2 1122137.AQXF01000002_gene37 1.18e-83 259.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2TQYQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P phosphate transport system permease pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3333 k59_1138548_2 1231391.AMZF01000042_gene814 7.49e-35 121.0 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,2VSI3@28216|Betaproteobacteria,3T49I@506|Alcaligenaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_874586_1 94122.Shewana3_3829 5.68e-46 169.0 COG3292@1|root,COG5001@1|root,COG3292@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2Q8ZG@267890|Shewanellaceae 1236|Gammaproteobacteria T Two component regulator three Y domain protein - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_9,Reg_prop,Y_Y_Y k59_1246368_1 1279015.KB908466_gene3 4.44e-09 61.2 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1Y40D@135624|Aeromonadales 135624|Aeromonadales D Ftsk_gamma - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1453505_1 243233.MCA0095 5.7e-51 182.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1XEV2@135618|Methylococcales 135618|Methylococcales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_1545417_1 472759.Nhal_3582 3.7e-34 125.0 COG0569@1|root,COG0569@2|Bacteria,1RIP2@1224|Proteobacteria,1SKEI@1236|Gammaproteobacteria,1X03Z@135613|Chromatiales 135613|Chromatiales P TrkA-C domain - - - - - - - - - - - - TrkA_C k59_147148_1 268746.Q58MG0_BPPRM 4.41e-68 221.0 4QDUC@10239|Viruses,4QV7K@35237|dsDNA viruses no RNA stage,4QR22@28883|Caudovirales,4QJ6D@10662|Myoviridae 10662|Myoviridae S transferase activity - - - - - - - - - - - - - k59_1394862_1 1278073.MYSTI_02981 1.12e-24 102.0 COG1607@1|root,COG1607@2|Bacteria,1RAEQ@1224|Proteobacteria,42SPA@68525|delta/epsilon subdivisions,2WPPE@28221|Deltaproteobacteria,2YVJ2@29|Myxococcales 28221|Deltaproteobacteria I Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_930135_1 1122134.KB893651_gene2215 1.4e-92 282.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1XIP7@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1031060_1 1469245.JFBG01000004_gene341 1.67e-38 132.0 COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria 1224|Proteobacteria S Regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 k59_1339512_1 85643.Tmz1t_2949 7.19e-59 196.0 COG1924@1|root,COG1924@2|Bacteria,1R411@1224|Proteobacteria,2WE9R@28216|Betaproteobacteria,2M03N@206389|Rhodocyclales 206389|Rhodocyclales I BadF/BadG/BcrA/BcrD ATPase family - - 1.3.7.8 ko:K04114 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - BcrAD_BadFG k59_1667415_1 511.JT27_01780 4.07e-79 249.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,3T2U3@506|Alcaligenaceae 28216|Betaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_612601_1 1469245.JFBG01000002_gene439 4.45e-51 173.0 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,1RN9B@1236|Gammaproteobacteria 1236|Gammaproteobacteria C carnitine dehydratase - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_1138569_1 330214.NIDE3945 1.06e-60 199.0 COG0025@1|root,COG0025@2|Bacteria 2|Bacteria P sodium:proton antiporter activity nhaP - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger k59_1339513_1 1198232.CYCME_0364 3.56e-27 112.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,45ZT8@72273|Thiotrichales 72273|Thiotrichales S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_1453518_1 401526.TcarDRAFT_2584 1.07e-07 57.4 COG2801@1|root,COG2801@2|Bacteria,1TQH6@1239|Firmicutes,4H6A4@909932|Negativicutes 909932|Negativicutes L Mu transposase, C-terminal - - - - - - - - - - - - Mu-transpos_C,rve k59_1545435_1 1125863.JAFN01000001_gene3055 2.35e-39 150.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Penicillin-binding protein, 1A family mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_1086584_1 483219.LILAB_27060 8.43e-58 200.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2YY4Y@29|Myxococcales 28221|Deltaproteobacteria O Belongs to the heat shock protein 70 family - - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70,PilZ k59_190508_1 477641.MODMU_2598 2.1e-11 69.3 COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,4ERPJ@85013|Frankiales 201174|Actinobacteria O ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis arc GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369 - ko:K13527 ko03050,map03050 M00342 - - ko00000,ko00001,ko00002,ko03051 - - - AAA,Prot_ATP_ID_OB k59_1140039_2 1131553.JIBI01000004_gene375 7.23e-12 65.1 COG1215@1|root,COG1215@2|Bacteria,1MW1E@1224|Proteobacteria,2VJ3J@28216|Betaproteobacteria,372P6@32003|Nitrosomonadales 28216|Betaproteobacteria M glycosyl transferase, family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 k59_1396039_1 1028307.EAE_06480 8.38e-16 75.5 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,3WZWR@547|Enterobacter 1236|Gammaproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN746.PP_4715 TIM k59_1396039_2 1396858.Q666_06855 3.43e-25 100.0 COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,1SD3P@1236|Gammaproteobacteria,467VJ@72275|Alteromonadaceae 1236|Gammaproteobacteria U Preprotein translocase subunit SecG secG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_304539_1 1229909.NSED_08400 5.41e-19 92.4 arCOG07561@1|root,arCOG07561@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - TSP_3,VWA k59_875931_1 4098.XP_009602761.1 8.53e-123 366.0 COG0334@1|root,KOG2250@2759|Eukaryota,37Q3I@33090|Viridiplantae,3GC9F@35493|Streptophyta,44MDI@71274|asterids 35493|Streptophyta E Belongs to the Glu Leu Phe Val dehydrogenases family - GO:0000166,GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005773,GO:0005774,GO:0006950,GO:0006970,GO:0006995,GO:0007154,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009267,GO:0009268,GO:0009605,GO:0009628,GO:0009651,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010446,GO:0016020,GO:0016491,GO:0016638,GO:0016639,GO:0017076,GO:0030554,GO:0031090,GO:0031667,GO:0031668,GO:0031669,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0035639,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043562,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0046686,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0051716,GO:0055114,GO:0071496,GO:0097159,GO:0097367,GO:0098588,GO:0098805,GO:1901265,GO:1901363 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_304541_1 330214.NIDE0351 5.25e-92 296.0 COG3127@1|root,COG3127@2|Bacteria 2|Bacteria Q FtsX-like permease family MA20_43810 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1396042_1 315749.Bcer98_2961 2.52e-48 163.0 2B9XI@1|root,323AV@2|Bacteria,1V7VV@1239|Firmicutes,4HK2T@91061|Bacilli,1ZMSA@1386|Bacillus 91061|Bacilli S Protein of unknown function (DUF1071) - - - - - - - - - - - - DUF1071 k59_1396043_1 765912.Thimo_0466 1.55e-91 285.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales 135613|Chromatiales C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_721412_1 243233.MCA0195 3.04e-62 204.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1XE7S@135618|Methylococcales 135618|Methylococcales S Belongs to the RtcB family rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_721412_2 1026882.MAMP_02431 7.71e-52 179.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,462DX@72273|Thiotrichales 72273|Thiotrichales M PFAM Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_407130_2 765911.Thivi_1140 2.22e-41 142.0 COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,1RMHS@1236|Gammaproteobacteria,1WY1C@135613|Chromatiales 135613|Chromatiales F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_461860_2 754476.Q7A_1140 5.64e-59 190.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1RPHB@1236|Gammaproteobacteria,4605I@72273|Thiotrichales 72273|Thiotrichales M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_1340705_1 1280944.HY17_18795 9.65e-112 328.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_32,rve,rve_3 k59_770791_1 911045.PSE_4301 1.86e-49 178.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria 28211|Alphaproteobacteria EQ N-methylhydantoinase A acetone carboxylase, beta subunit oplA - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_1247615_1 1229909.NSED_06105 3.73e-111 336.0 COG1793@1|root,arCOG01347@2157|Archaea,41SCK@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair lig - 6.5.1.1,6.5.1.6,6.5.1.7 ko:K10747 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N k59_461866_1 330214.NIDE0595 6.15e-101 310.0 COG0322@1|root,COG0322@2|Bacteria,3J0F1@40117|Nitrospirae 40117|Nitrospirae L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N k59_192009_1 446462.Amir_4700 5.08e-27 105.0 COG1853@1|root,COG1853@2|Bacteria,2GMPH@201174|Actinobacteria,4E4PC@85010|Pseudonocardiales 201174|Actinobacteria S PFAM flavin reductase domain protein FMN-binding - - - ko:K21185 ko01059,ko01130,map01059,map01130 M00827,M00828,M00832 R11368,R11393 RC00949,RC03431 ko00000,ko00001,ko00002 - - - Flavin_Reduct k59_1087977_1 1128427.KB904821_gene4236 2.27e-06 48.9 COG0464@1|root,COG0464@2|Bacteria,1G2M7@1117|Cyanobacteria,1HE1K@1150|Oscillatoriales 1117|Cyanobacteria O PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_1087977_2 1121468.AUBR01000005_gene18 1.86e-25 109.0 COG1293@1|root,COG1293@2|Bacteria,1TQ8A@1239|Firmicutes,248RK@186801|Clostridia,42F75@68295|Thermoanaerobacterales 186801|Clostridia K Fibronectin-binding A domain protein FbpA - - - - - - - - - - - DUF814,FbpA k59_192014_1 1472418.BBJC01000005_gene2167 0.00019 44.7 COG3119@1|root,COG3119@2|Bacteria,1QYUG@1224|Proteobacteria 1224|Proteobacteria P COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - Sulfatase,YHYH k59_192014_2 1123318.KB904620_gene1962 1.03e-06 52.4 COG0745@1|root,COG0745@2|Bacteria,1TR8K@1239|Firmicutes 1239|Firmicutes T response regulator, receiver - - - - - - - - - - - - Response_reg,Trans_reg_C k59_931616_1 1230460.C495_12115 5.16e-09 59.3 COG1999@1|root,arCOG00313@2157|Archaea,2XUQD@28890|Euryarchaeota,23UAI@183963|Halobacteria 183963|Halobacteria S protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_931616_2 1123372.AUIT01000008_gene591 2.31e-08 55.8 COG0126@1|root,COG0126@2|Bacteria,2GGQP@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria G Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_1087983_1 366394.Smed_5151 7.14e-120 355.0 COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,2TVIR@28211|Alphaproteobacteria,4BHAQ@82115|Rhizobiaceae 28211|Alphaproteobacteria L High confidence in function and specificity - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_721444_1 247639.MGP2080_09933 2.42e-81 263.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MU7M@1224|Proteobacteria,1RP7W@1236|Gammaproteobacteria 1236|Gammaproteobacteria E fad dependent oxidoreductase - - 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO,FAO_M,GCV_T,GCV_T_C k59_572576_1 1121405.dsmv_1436 2.74e-130 385.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MJ0Z@213118|Desulfobacterales 28221|Deltaproteobacteria F Belongs to the formate--tetrahydrofolate ligase family fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_1613416_1 330214.NIDE3434 4.3e-38 135.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - pilI - - - - - - - - - - - ABC2_membrane_2 k59_1560592_1 765698.Mesci_1369 2.38e-12 72.0 COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2TURQ@28211|Alphaproteobacteria,43PQD@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q Methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_259544_1 1469557.JSWF01000016_gene2199 1.52e-25 112.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity - - - - - - - - - - - - ASH,AhpC-TSA,LVIVD,NosL,UnbV_ASPIC,VCBS k59_1408462_1 45351.EDO47569 3.82e-51 177.0 COG1960@1|root,KOG0139@2759|Eukaryota,38H6J@33154|Opisthokonta,3BC6X@33208|Metazoa 33208|Metazoa I oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor ACADS GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006139,GO:0006351,GO:0006352,GO:0006366,GO:0006367,GO:0006629,GO:0006631,GO:0006635,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0010467,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016070,GO:0016491,GO:0016592,GO:0016627,GO:0017076,GO:0018130,GO:0019395,GO:0019438,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032787,GO:0032991,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044271,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0046483,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901567,GO:1901575,GO:1901576,GO:1901681 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_991816_1 566466.NOR53_970 7.52e-48 166.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1SMVF@1236|Gammaproteobacteria,1J8W1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - - - - - - - - - - - ArgJ k59_991816_2 83406.HDN1F_06810 3.33e-53 184.0 COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,1RS3S@1236|Gammaproteobacteria,1J6KJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes mutT GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008413,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017110,GO:0030145,GO:0033554,GO:0034641,GO:0035539,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044715,GO:0044716,GO:0046483,GO:0046872,GO:0046914,GO:0047429,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - iE2348C_1286.E2348C_0104,iSDY_1059.SDY_0129 NUDIX,NUDIX_4,TMP-TENI k59_991816_4 754477.Q7C_2224 2.89e-19 87.0 COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,460VI@72273|Thiotrichales 72273|Thiotrichales D Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity zapD - - ko:K18778 - - - - ko00000,ko03036 - - - ZapD k59_780457_1 1131269.AQVV01000024_gene2365 1.14e-64 216.0 COG1232@1|root,COG1232@2|Bacteria 2|Bacteria H protoporphyrinogen oxidase activity hemY - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS09325 Amino_oxidase k59_259573_1 270374.MELB17_01495 1.89e-23 94.4 COG3011@1|root,COG3011@2|Bacteria 2|Bacteria CH Protein conserved in bacteria - - - - - - - - - - - - DUF393 k59_259573_2 360910.BAV1599 2.2e-13 70.1 COG0789@1|root,COG0789@2|Bacteria,1RFQI@1224|Proteobacteria,2VS80@28216|Betaproteobacteria 28216|Betaproteobacteria K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 k59_1353188_1 351348.Maqu_0687 7.1e-12 64.3 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,1S6QS@1236|Gammaproteobacteria,46740@72275|Alteromonadaceae 1236|Gammaproteobacteria H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_1353188_2 640081.Dsui_0662 1.11e-87 268.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2VKD2@28216|Betaproteobacteria,2KVE8@206389|Rhodocyclales 206389|Rhodocyclales H Phosphomethylpyrimidine kinase - - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_1042060_1 545264.KB898744_gene2063 3.59e-73 232.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria,1WX6Z@135613|Chromatiales 135613|Chromatiales F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_1197064_1 1198232.CYCME_0104 1.61e-48 175.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,46225@72273|Thiotrichales 72273|Thiotrichales S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_24101_1 357808.RoseRS_3547 6.05e-16 75.1 COG1950@1|root,COG1950@2|Bacteria,2G7E6@200795|Chloroflexi,375XQ@32061|Chloroflexia 32061|Chloroflexia S PFAM membrane protein of - - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 k59_24101_2 1313301.AUGC01000001_gene1750 1.15e-12 68.6 COG1301@1|root,COG1301@2|Bacteria,4NDUU@976|Bacteroidetes 976|Bacteroidetes C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltP - - ko:K11102,ko:K11103 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.23.1.1,2.A.23.1.2,2.A.23.1.3,2.A.23.1.6,2.A.23.1.7 - - SDF k59_1560730_1 243159.AFE_1503 2.11e-14 78.6 COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,1RS1G@1236|Gammaproteobacteria,2NC5Y@225057|Acidithiobacillales 225057|Acidithiobacillales C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_991939_1 1254432.SCE1572_23055 5.33e-24 103.0 COG1355@1|root,COG1355@2|Bacteria,1N5H1@1224|Proteobacteria,42TIN@68525|delta/epsilon subdivisions,2WR24@28221|Deltaproteobacteria,2Z1BF@29|Myxococcales 28221|Deltaproteobacteria S Memo-like protein - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_780530_1 1278309.KB907100_gene2323 4.02e-54 176.0 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S5Y0@1236|Gammaproteobacteria,1XK0E@135619|Oceanospirillales 135619|Oceanospirillales Q TRAP-type mannitol chloroaromatic compound transport system, small permease component gtrA - - - - - - - - - - - DctQ k59_991946_2 450851.PHZ_c1001 4.43e-22 95.9 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,2KFVB@204458|Caulobacterales 204458|Caulobacterales V beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_991960_1 631362.Thi970DRAFT_03866 1.28e-53 187.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1WVZ6@135613|Chromatiales 135613|Chromatiales M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - DUF3340,PDZ,Peptidase_S41 k59_780549_1 247490.KSU1_D0533 1.16e-70 226.0 COG0148@1|root,COG0148@2|Bacteria,2IXRG@203682|Planctomycetes 203682|Planctomycetes G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_1560782_2 1278309.KB907101_gene524 2.92e-29 112.0 COG0730@1|root,COG0730@2|Bacteria,1MWAN@1224|Proteobacteria,1S5RQ@1236|Gammaproteobacteria,1XJIW@135619|Oceanospirillales 135619|Oceanospirillales S Sulfite exporter TauE/SafE - - - - - - - - - - - - TauE k59_1560813_1 1313172.YM304_16810 3.85e-52 183.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - 2.3.1.82 ko:K18815 - - - - br01600,ko00000,ko01000,ko01504 - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_1353277_1 1248917.ANFX01000030_gene511 1.04e-44 159.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria,2JZXP@204457|Sphingomonadales 204457|Sphingomonadales Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_3 k59_259696_1 443144.GM21_3501 2.17e-126 370.0 COG0463@1|root,COG0463@2|Bacteria,1QTWH@1224|Proteobacteria,43CTF@68525|delta/epsilon subdivisions,2X80Z@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_992024_1 314278.NB231_06296 7.59e-15 73.9 COG1763@1|root,COG1763@2|Bacteria,1QYTH@1224|Proteobacteria,1T3U1@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Mo-molybdopterin cofactor biosynthetic process - - - - - - - - - - - - - k59_992024_2 1198232.CYCME_0391 1.46e-25 99.8 COG2259@1|root,COG2259@2|Bacteria,1RBZP@1224|Proteobacteria,1S28E@1236|Gammaproteobacteria,460P8@72273|Thiotrichales 72273|Thiotrichales S DoxX - - - - - - - - - - - - DoxX k59_1560839_1 631362.Thi970DRAFT_03291 4.23e-33 122.0 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,1WY3H@135613|Chromatiales 135613|Chromatiales L Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_1357638_2 289376.THEYE_A0868 2.24e-18 83.6 COG0319@1|root,COG0319@2|Bacteria,3J0US@40117|Nitrospirae 40117|Nitrospirae J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_1357657_1 870187.Thini_1465 2.71e-29 114.0 COG0730@1|root,COG0730@2|Bacteria 2|Bacteria S response to heat - - - ko:K07090 - - - - ko00000 - - - TauE k59_26143_1 1183438.GKIL_1934 7.16e-28 104.0 COG0822@1|root,COG0822@2|Bacteria,1G590@1117|Cyanobacteria 1117|Cyanobacteria C SUF system FeS assembly protein, NifU family - - - ko:K04488 - - - - ko00000 - - - NifU_N k59_26143_2 378806.STAUR_1772 8.07e-199 562.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,42PJT@68525|delta/epsilon subdivisions,2WKPW@28221|Deltaproteobacteria,2YXCR@29|Myxococcales 28221|Deltaproteobacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_1357826_2 45157.CMI219CT 2.53e-70 230.0 28NCX@1|root,2QUYC@2759|Eukaryota 2759|Eukaryota S Glutathione S-transferase, N-terminal domain - - - ko:K03354 ko04110,ko04111,ko04113,ko04114,ko04120,ko04914,ko05166,map04110,map04111,map04113,map04114,map04120,map04914,map05166 M00389 - - ko00000,ko00001,ko00002,ko03036,ko04121 - - - GST_N_3 k59_1357826_3 595460.RRSWK_03194 2.53e-27 114.0 COG2239@1|root,COG2239@2|Bacteria,2IYCZ@203682|Planctomycetes 203682|Planctomycetes P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_26232_1 1229909.NSED_09465 3.72e-121 353.0 COG0517@1|root,arCOG00600@2157|Archaea,41TAT@651137|Thaumarchaeota 651137|Thaumarchaeota S CBS domain - - - - - - - - - - - - CBS k59_1617140_1 1207063.P24_03830 1.6e-105 334.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria,2JP8A@204441|Rhodospirillales 204441|Rhodospirillales C FAD linked oxidases, C-terminal domain - - - ko:K18930 - - - - ko00000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_1358021_1 1280952.HJA_13225 1.29e-99 309.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit MA20_01045 - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1617237_1 870967.VIS19158_05688 3.17e-119 356.0 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,1XU2Z@135623|Vibrionales 135623|Vibrionales U COG1115 Na alanine symporter - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_26294_1 330214.NIDE3400 4.07e-58 192.0 COG0395@1|root,COG0395@2|Bacteria 2|Bacteria P glycerophosphodiester transmembrane transport - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_26294_2 710111.FraQA3DRAFT_1732 1.72e-96 294.0 COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4ES4E@85013|Frankiales 201174|Actinobacteria P Belongs to the ABC transporter superfamily sugC GO:0006810,GO:0008150,GO:0008643,GO:0009405,GO:0015766,GO:0015771,GO:0015772,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051179,GO:0051234,GO:0051704,GO:0071702 - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran k59_26322_1 745411.B3C1_11334 2.49e-93 302.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5K5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_26429_1 690850.Desaf_2364 1.39e-30 123.0 28HC9@1|root,2Z7P5@2|Bacteria,1R4BH@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1617705_1 177437.HRM2_44710 1.18e-97 300.0 COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria 1224|Proteobacteria K iron dependent repressor - - - - - - - - - - - - - k59_26528_1 557393.B8QTP9_9CAUD 1.42e-17 90.5 4QFRX@10239|Viruses,4QWQF@35237|dsDNA viruses no RNA stage,4QUAP@28883|Caudovirales,4QJCG@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1617740_2 937777.Deipe_0633 2.61e-88 268.0 COG0039@1|root,COG0039@2|Bacteria,1WJHY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Catalyzes the reversible oxidation of malate to oxaloacetate mdh GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_26587_1 1173026.Glo7428_1784 5.03e-317 882.0 COG3957@1|root,COG3957@2|Bacteria,1G0B2@1117|Cyanobacteria 1117|Cyanobacteria G D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase - - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_26657_1 266117.Rxyl_2832 3.51e-26 112.0 COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4CRXQ@84995|Rubrobacteria 84995|Rubrobacteria C FAD linked oxidases, C-terminal domain - - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 k59_1618026_1 335543.Sfum_3516 3.03e-135 399.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria,2MQTV@213462|Syntrophobacterales 28221|Deltaproteobacteria J tRNA synthetases class I (E and Q), anti-codon binding domain glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C k59_1618217_1 1410618.JNKI01000007_gene778 3.6e-19 84.0 COG1778@1|root,COG1778@2|Bacteria,1V5JJ@1239|Firmicutes,4H4ID@909932|Negativicutes 909932|Negativicutes S 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family kdsC - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 k59_1618217_2 857087.Metme_0702 1.36e-28 112.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1XDSG@135618|Methylococcales 135618|Methylococcales M Arabinose 5-phosphate isomerase - - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_1618316_1 1104324.P186_0777 3.4e-17 85.9 COG5013@1|root,arCOG01497@2157|Archaea 2157|Archaea C nitrate reductase, alpha subunit narG - 1.7.5.1 ko:K00370,ko:K17050 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8 - - Molybdopterin,Molydop_binding,Nitr_red_alph_N k59_1618522_1 671143.DAMO_0754 1.89e-54 186.0 COG0260@1|root,COG0260@2|Bacteria,2NNKH@2323|unclassified Bacteria 2|Bacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141 3.4.11.1,3.4.11.5 ko:K01255,ko:K01259 ko00330,ko00480,ko01100,map00330,map00480,map01100 - R00135,R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_1618657_1 1140.Synpcc7942_0272 8.65e-11 66.6 COG1587@1|root,COG1587@2|Bacteria,1G1Y4@1117|Cyanobacteria,1GYDJ@1129|Synechococcus 1117|Cyanobacteria H Uroporphyrinogen-III synthase hemD - 2.1.1.107,4.2.1.75 ko:K01719,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 - - iJN678.hemD HEM4,TP_methylase k59_1618675_1 1177928.TH2_13117 6.74e-39 147.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,2JQCH@204441|Rhodospirillales 204441|Rhodospirillales I Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus phbC - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1,PhaC_N k59_1618675_2 414684.RC1_2673 3.49e-20 85.9 2BZNP@1|root,30717@2|Bacteria,1REWN@1224|Proteobacteria,2U7X0@28211|Alphaproteobacteria,2JSDR@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function (DUF2889) - - - - - - - - - - - - DUF2889 k59_27053_1 1283300.ATXB01000001_gene1250 2.76e-46 150.0 2C82G@1|root,32RK9@2|Bacteria,1MZV5@1224|Proteobacteria,1SAWR@1236|Gammaproteobacteria,1XFGD@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF4242) - - - - - - - - - - - - DUF4242 k59_1618841_1 118168.MC7420_4867 5.98e-32 129.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1G2UN@1117|Cyanobacteria,1H977@1150|Oscillatoriales 1117|Cyanobacteria G Alpha amylase, catalytic domain - - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - APH,Alpha-amylase,Malt_amylase_C k59_1618843_1 1120956.JHZK01000021_gene1620 3.14e-78 257.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2TVZI@28211|Alphaproteobacteria,1JPWU@119043|Rhodobiaceae 28211|Alphaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain fdhA - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_27120_1 1229909.NSED_01465 1.69e-103 309.0 COG0598@1|root,arCOG02265@2157|Archaea,41SZC@651137|Thaumarchaeota 651137|Thaumarchaeota P Mg2 transporter protein - - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_1618894_1 187272.Mlg_2525 1.25e-10 60.8 2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SHAU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1618894_2 472759.Nhal_0667 1.24e-43 157.0 COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,1RNFJ@1236|Gammaproteobacteria,1WWXB@135613|Chromatiales 135613|Chromatiales T PFAM PrkA AAA - - - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_1618897_1 95619.PM1_0226700 4.76e-64 202.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria 1236|Gammaproteobacteria J catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_1618912_1 713586.KB900536_gene1703 3e-68 217.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,1WWU0@135613|Chromatiales 135613|Chromatiales F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_1618912_2 768671.ThimaDRAFT_3042 1.16e-44 157.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1WVVC@135613|Chromatiales 135613|Chromatiales F TIGRFAM dihydroorotase, multifunctional complex type - - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_1618964_1 316067.Geob_1470 1.47e-20 90.1 COG1497@1|root,COG1497@2|Bacteria,1QXN4@1224|Proteobacteria,43C48@68525|delta/epsilon subdivisions,2X7EN@28221|Deltaproteobacteria,43V1T@69541|Desulfuromonadales 28221|Deltaproteobacteria K Winged helix-turn-helix DNA-binding - - - - - - - - - - - - HTH_24 k59_1624336_3 1123258.AQXZ01000017_gene4365 6.51e-46 172.0 COG3670@1|root,COG3670@2|Bacteria,2GK7D@201174|Actinobacteria,4FYY3@85025|Nocardiaceae 201174|Actinobacteria Q Retinal pigment epithelial membrane protein - - 1.13.11.75 ko:K00464,ko:K11159 - - R09601 RC00912 ko00000,ko01000 - - - RPE65 k59_318880_1 1121035.AUCH01000004_gene429 2.35e-128 412.0 COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria 1224|Proteobacteria I CoA-substrate-specific enzyme activase - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_2687_1 1469607.KK073769_gene5965 2.95e-29 121.0 COG1361@1|root,COG2373@1|root,COG1361@2|Bacteria,COG2373@2|Bacteria,1G6ER@1117|Cyanobacteria,1HQ0Q@1161|Nostocales 1117|Cyanobacteria M Conserved repeat - - - - - - - - - - - - DUF11 k59_633158_1 1485544.JQKP01000002_gene1516 1.73e-108 326.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VISB@28216|Betaproteobacteria,44VMS@713636|Nitrosomonadales 28216|Betaproteobacteria I PFAM Carbamoyl-phosphate synthase L chain ATP-binding accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_789755_2 404589.Anae109_0974 4.27e-50 169.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,42MTF@68525|delta/epsilon subdivisions,2WJ6X@28221|Deltaproteobacteria 28221|Deltaproteobacteria D PFAM Cobyrinic acid ac-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_893249_1 1238182.C882_1657 1.54e-47 174.0 COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2TRCR@28211|Alphaproteobacteria,2JQS2@204441|Rhodospirillales 204441|Rhodospirillales C Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate cysI - 1.8.1.2,1.8.7.1 ko:K00381,ko:K00392 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858,R00859,R03600 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_893249_2 1121937.AUHJ01000001_gene612 4.38e-98 323.0 COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,1RSCG@1236|Gammaproteobacteria,4668T@72275|Alteromonadaceae 1236|Gammaproteobacteria H Elongator protein 3, MiaB family, Radical SAM - - 2.5.1.77 ko:K11779 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - CofC,Radical_SAM k59_893249_3 1459636.NTE_02502 1.99e-74 238.0 COG1060@1|root,arCOG00656@2157|Archaea,41SDT@651137|Thaumarchaeota 651137|Thaumarchaeota H Radical SAM - - 2.5.1.77 ko:K11781 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_1259971_1 448385.sce9218 4.37e-10 60.8 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2YUKY@29|Myxococcales 28221|Deltaproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1259971_2 1144275.COCOR_05577 8.52e-15 76.6 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2YTZT@29|Myxococcales 28221|Deltaproteobacteria U General secretion pathway protein F gspF - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF k59_1310798_1 506534.Rhein_2380 6.13e-38 135.0 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1WW8M@135613|Chromatiales 135613|Chromatiales L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_789759_1 1168065.DOK_10917 3.49e-70 232.0 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - DUF3347,HlyD_D23,HlyD_D4,YtkA k59_840872_1 469371.Tbis_0748 5.42e-39 144.0 COG0778@1|root,COG1478@1|root,COG0778@2|Bacteria,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4DX67@85010|Pseudonocardiales 201174|Actinobacteria C F420-0 Gamma-glutamyl ligase fbiB GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944 6.3.2.31,6.3.2.34 ko:K12234 ko00680,ko01120,map00680,map01120 M00378 R09399,R09400 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000 - - - F420_ligase,Nitroreductase k59_685285_1 1157490.EL26_15175 5.17e-48 174.0 COG2352@1|root,COG2352@2|Bacteria,1TQB6@1239|Firmicutes,4HCAF@91061|Bacilli,278RF@186823|Alicyclobacillaceae 91061|Bacilli C Phosphoenolpyruvate carboxylase ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_213940_2 1504823.CCMM01000008_gene908 1.86e-06 52.8 COG0667@1|root,COG0667@2|Bacteria,2NQAG@2323|unclassified Bacteria 2|Bacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_58517_1 1218084.BBJK01000167_gene7808 6.9e-54 181.0 COG3386@1|root,COG3386@2|Bacteria,1PIAT@1224|Proteobacteria,2W6Y9@28216|Betaproteobacteria,1KD83@119060|Burkholderiaceae 28216|Betaproteobacteria G SMP-30/Gluconolaconase/LRE-like region - - - - - - - - - - - - SGL k59_1518702_1 247490.KSU1_C0048 1.36e-05 49.3 COG2211@1|root,COG2211@2|Bacteria,2IY9C@203682|Planctomycetes 203682|Planctomycetes G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1518702_3 296591.Bpro_2784 7.25e-08 53.1 COG0614@1|root,COG0614@2|Bacteria,1PKNF@1224|Proteobacteria,2VMK5@28216|Betaproteobacteria,4AA7N@80864|Comamonadaceae 28216|Betaproteobacteria P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_59337_1 522306.CAP2UW1_4152 1.85e-51 173.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VJAP@28216|Betaproteobacteria,1KQK0@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Cytochrome c oxidase subunit III coxC - 1.9.3.1 ko:K02276,ko:K02299 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.5,3.D.4.6 - - COX3 k59_1624925_1 247633.GP2143_17486 1.4e-14 78.6 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1JAKV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG2211 Na melibiose symporter and related transporters - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_686056_1 314225.ELI_11930 1.04e-22 100.0 COG0625@1|root,COG0625@2|Bacteria,1R3VG@1224|Proteobacteria,2U50H@28211|Alphaproteobacteria,2K4VH@204457|Sphingomonadales 204457|Sphingomonadales O Glutathione S-transferase, C-terminal domain - - - - - - - - - - - - GST_C_2,GST_N_3 k59_1102757_2 521674.Plim_0173 1.85e-11 67.8 COG0712@1|root,COG0712@2|Bacteria,2J09A@203682|Planctomycetes 203682|Planctomycetes C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_1468888_1 290397.Adeh_1083 2.78e-36 141.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,42M4X@68525|delta/epsilon subdivisions,2WJJY@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_736915_1 1229909.NSED_09175 3.39e-49 163.0 arCOG10600@1|root,arCOG10600@2157|Archaea,41T8K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_319556_1 2340.JV46_14290 3.76e-19 86.7 COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit - - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_1208658_2 391937.NA2_20452 2.26e-12 65.9 COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2UCYK@28211|Alphaproteobacteria,43KDC@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T Universal stress protein - - - - - - - - - - - - Usp k59_1208659_1 760568.Desku_1394 5.89e-73 244.0 COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,248PM@186801|Clostridia,260EY@186807|Peptococcaceae 186801|Clostridia S PFAM Uncharacterised protein family UPF0182 - - - ko:K09118 - - - - ko00000 - - - UPF0182 k59_214515_1 1379270.AUXF01000002_gene1177 4.13e-23 101.0 COG2204@1|root,COG2204@2|Bacteria,1ZUNI@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_266954_1 159749.K0RC06 5.35e-22 97.1 COG0120@1|root,KOG3075@2759|Eukaryota,2XAXE@2836|Bacillariophyta 2836|Bacillariophyta G Ribose 5-phosphate isomerase A (phosphoriboisomerase A) - - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A k59_266954_2 1303518.CCALI_00794 2.52e-47 159.0 COG0036@1|root,COG0036@2|Bacteria 2|Bacteria G ribulose-phosphate 3-epimerase activity rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_1260775_1 444860.E3SJ24_9CAUD 1.3e-158 462.0 4QAKZ@10239|Viruses,4QUSW@35237|dsDNA viruses no RNA stage,4QPYH@28883|Caudovirales,4QIYN@10662|Myoviridae 10662|Myoviridae S exonuclease activity - - - - - - - - - - - - - k59_1260775_2 268746.Q58MK8_BPPRM 1.58e-20 85.1 4QBEN@10239|Viruses,4QW43@35237|dsDNA viruses no RNA stage,4QPWZ@28883|Caudovirales,4QI7M@10662|Myoviridae 10662|Myoviridae S Protein of unknown function (DUF3110) - - - - - - - - - - - - - k59_1260775_3 444860.E3SJ22_9CAUD 2.41e-38 138.0 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales,4QHXI@10662|Myoviridae 10662|Myoviridae S hydrolase activity - - - - - - - - - - - - - k59_1468901_1 635013.TherJR_1812 1.34e-17 87.0 COG1509@1|root,COG1509@2|Bacteria,1TQQZ@1239|Firmicutes,249JV@186801|Clostridia,2600N@186807|Peptococcaceae 186801|Clostridia E Lysine 2,3-aminomutase YodO family protein kamA GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0016853,GO:0016866,GO:0016869,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0051536,GO:0051540,GO:0070279,GO:0097159,GO:1901363 5.4.3.9 ko:K19814 - - - - ko00000,ko01000 - - - Fer4_14,LAM_C,Radical_SAM k59_423551_1 314278.NB231_01898 3.01e-08 57.8 28N07@1|root,2ZB6S@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_371312_1 870187.Thini_2685 8.51e-75 235.0 COG2878@1|root,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,1RPC4@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Fe-S cluster - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4 k59_2900_1 269799.Gmet_0133 1.28e-97 305.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2WJG7@28221|Deltaproteobacteria,43STK@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_59370_1 337191.KTR9_0801 1.5e-56 186.0 COG2030@1|root,COG2030@2|Bacteria,2GJJI@201174|Actinobacteria,4GASU@85026|Gordoniaceae 201174|Actinobacteria I N-terminal half of MaoC dehydratase hsd4B - - - - - - - - - - - MaoC_dehydrat_N,MaoC_dehydratas k59_59370_2 909613.UO65_5246 2.53e-57 195.0 COG2141@1|root,COG2141@2|Bacteria,2GNE9@201174|Actinobacteria,4DZRQ@85010|Pseudonocardiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_841477_1 243233.MCA2174 4.76e-56 185.0 COG0803@1|root,COG0803@2|Bacteria,1RAQU@1224|Proteobacteria 1224|Proteobacteria P Zinc-uptake complex component A periplasmic - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_633993_2 472759.Nhal_2956 6.74e-108 317.0 COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,1RSAG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 k59_2902_1 41431.PCC8801_2360 5.42e-76 241.0 COG2403@1|root,COG2403@2|Bacteria,1G1FF@1117|Cyanobacteria,3KH0Q@43988|Cyanothece 1117|Cyanobacteria S cyclic 2,3-diphosphoglycerate synthetase activity - - - - - - - - - - - - cobW k59_527848_1 36809.MAB_0834 1.08e-25 107.0 COG1024@1|root,COG1024@2|Bacteria,2IF91@201174|Actinobacteria,23EWK@1762|Mycobacteriaceae 201174|Actinobacteria I Enoyl-coA hydratase isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_790559_1 1198452.Jab_2c02580 6.9e-56 188.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VI1J@28216|Betaproteobacteria,478HA@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Type II secretion system (T2SS), protein F pilC2 - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_1363819_1 1286106.MPL1_01632 9.35e-107 315.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,460E7@72273|Thiotrichales 72273|Thiotrichales E Pyridoxal-phosphate dependent enzyme - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1468921_1 1304883.KI912532_gene1218 5.84e-57 195.0 COG2206@1|root,COG2206@2|Bacteria,1R3VR@1224|Proteobacteria,2VMY5@28216|Betaproteobacteria,2KVPZ@206389|Rhodocyclales 206389|Rhodocyclales T Domain of unknown function (DUF3391) - - - - - - - - - - - - DUF3391,HD_5 k59_736939_1 96561.Dole_0941 8.85e-47 162.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,42M3F@68525|delta/epsilon subdivisions,2WJ32@28221|Deltaproteobacteria,2MIH7@213118|Desulfobacterales 28221|Deltaproteobacteria EP Belongs to the ABC transporter superfamily - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_997895_1 1254432.SCE1572_34585 1.73e-89 273.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) tnp3510a - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_736940_1 1131451.O1K_06532 2.38e-73 241.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1X3IX@135614|Xanthomonadales 135614|Xanthomonadales C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_1624961_1 1298880.AUEV01000002_gene1567 5.88e-24 105.0 COG2303@1|root,COG2303@2|Bacteria,2GJKS@201174|Actinobacteria 201174|Actinobacteria E Oxidoreductase - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - GMC_oxred_C,GMC_oxred_N,Gluconate_2-dh3 k59_893949_1 66869.JNXG01000021_gene4219 2.72e-58 202.0 COG1748@1|root,COG1748@2|Bacteria,2GMQ1@201174|Actinobacteria,41C3I@629295|Streptomyces griseus group 201174|Actinobacteria E Saccharopine dehydrogenase C-terminal domain lys1 - 1.5.1.7 ko:K00290 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715 RC00217,RC01532 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_2906_1 1121918.ARWE01000001_gene3299 2.94e-49 164.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria 1224|Proteobacteria T Response regulator containing a CheY-like receiver domain and an HD-GYP domain - - - - - - - - - - - - HD_5,Response_reg k59_686103_1 204773.HEAR3251 1.13e-13 73.2 COG1396@1|root,COG3837@1|root,COG1396@2|Bacteria,COG3837@2|Bacteria,1RCYA@1224|Proteobacteria,2VNAQ@28216|Betaproteobacteria,474H1@75682|Oxalobacteraceae 28216|Betaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - Cupin_2,HTH_31 k59_214545_1 714943.Mucpa_6918 8.59e-17 81.3 COG0422@1|root,COG0422@2|Bacteria,4NFTF@976|Bacteroidetes,1INSZ@117747|Sphingobacteriia 976|Bacteroidetes H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_1468935_1 1254432.SCE1572_18520 5.72e-83 259.0 COG2267@1|root,COG2267@2|Bacteria,1QZUV@1224|Proteobacteria 1224|Proteobacteria I carboxylic ester hydrolase activity - - - - - - - - - - - - - k59_736946_1 1122221.JHVI01000031_gene675 7.15e-31 124.0 COG0515@1|root,COG0515@2|Bacteria,1WMF0@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus KLT Protein tyrosine kinase - - - - - - - - - - - - Pkinase k59_1050545_1 562970.Btus_2562 4.36e-75 235.0 COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,4HB6V@91061|Bacilli,279MG@186823|Alicyclobacillaceae 91061|Bacilli IQ PFAM short-chain dehydrogenase reductase SDR fabG_4 - 1.1.1.69 ko:K00046 - - - - ko00000,ko01000 - - - adh_short_C2 k59_1572464_2 398767.Glov_1318 8.35e-49 164.0 COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,42MVZ@68525|delta/epsilon subdivisions,2WJ3N@28221|Deltaproteobacteria,43TZ4@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1986 Pan_kinase k59_109750_1 1411685.U062_02342 1e-44 149.0 COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,1T12G@1236|Gammaproteobacteria,1JBHI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Ferredoxin - - - - - - - - - - - - - k59_109750_2 1536775.H70737_06650 5.67e-22 97.1 COG0673@1|root,COG0673@2|Bacteria,1TRCC@1239|Firmicutes,4HEB9@91061|Bacilli,26STK@186822|Paenibacillaceae 91061|Bacilli S Oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_634021_1 1342302.JASC01000014_gene1842 1.28e-13 78.2 COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,2TSXQ@28211|Alphaproteobacteria,3ZW01@60136|Sulfitobacter 28211|Alphaproteobacteria F Inosine-uridine preferring nucleoside hydrolase rihA - 3.2.2.1 ko:K01239 ko00230,ko00760,ko01100,map00230,map00760,map01100 - R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 - - - IU_nuc_hydro k59_1102810_1 426117.M446_4662 5.04e-18 88.2 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,1JRA9@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM Peptidoglycan-binding domain 1 protein - - - ko:K21470,ko:K21572 - - - - ko00000,ko01002,ko01011,ko02000 8.A.46.1,8.A.46.3 - - PG_binding_1,YkuD k59_1416091_2 545696.HOLDEFILI_03856 7.1e-17 80.1 COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,3VR5M@526524|Erysipelotrichia 526524|Erysipelotrichia D Maf-like protein maf - - ko:K06287 - - - - ko00000 - - - Maf k59_1154901_1 998674.ATTE01000001_gene668 6.77e-44 152.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,4608G@72273|Thiotrichales 72273|Thiotrichales G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_1572471_1 580332.Slit_2310 2.11e-16 80.5 COG3103@1|root,COG3103@2|Bacteria,1N6AX@1224|Proteobacteria,2VVME@28216|Betaproteobacteria 28216|Betaproteobacteria T Bacterial SH3 domain - - - - - - - - - - - - SH3_3,SH3_4 k59_1468955_1 765912.Thimo_0183 3.76e-211 593.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1WWPY@135613|Chromatiales 135613|Chromatiales I TIGRFAM acetyl-CoA carboxylase, biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_580319_1 1469245.JFBG01000006_gene1597 5.14e-145 419.0 COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,1RRHH@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Sarcosine oxidase, subunit beta soxB - 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO k59_841518_1 765912.Thimo_0862 2.91e-59 194.0 COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria,1WXKU@135613|Chromatiales 135613|Chromatiales S PFAM Radical SAM - - - - - - - - - - - - DUF3641,Fer4_12,Radical_SAM k59_371355_1 1027273.GZ77_16795 1.86e-54 186.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1XHGA@135619|Oceanospirillales 135619|Oceanospirillales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_1576445_1 44060.JODL01000002_gene2150 3.82e-27 108.0 COG0385@1|root,COG0385@2|Bacteria,2GMAM@201174|Actinobacteria 201174|Actinobacteria S Bile acid - - - ko:K03453 - - - - ko00000 2.A.28 - - SBF k59_1629447_1 1123057.P872_12830 2.1e-21 98.6 COG4907@1|root,COG4907@2|Bacteria,4NJKC@976|Bacteroidetes,47U4J@768503|Cytophagia 976|Bacteroidetes S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_796346_1 1144275.COCOR_06731 1.44e-75 242.0 COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 k59_1107427_1 305700.B447_01881 0.000159 48.9 COG0847@1|root,COG0847@2|Bacteria,1RAF1@1224|Proteobacteria,2WC0K@28216|Betaproteobacteria,2KZAH@206389|Rhodocyclales 206389|Rhodocyclales L COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases - - - - - - - - - - - - RNase_T k59_1368380_3 518766.Rmar_2883 4.58e-19 84.0 COG1569@1|root,COG1569@2|Bacteria 2|Bacteria S PIN domain - - - ko:K07063 - - - - ko00000 - - - PIN_3 k59_1474666_1 981384.AEYW01000006_gene2519 3.28e-125 375.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria 28211|Alphaproteobacteria P arylsulfatase A - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - DUF4994,Sulfatase,Sulfatase_C k59_1576796_1 269799.Gmet_2580 1.99e-237 711.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_65353_1 1121106.JQKB01000006_gene1164 3.44e-93 293.0 COG5476@1|root,COG5476@2|Bacteria,1NS9S@1224|Proteobacteria,2UNYM@28211|Alphaproteobacteria,2JVCG@204441|Rhodospirillales 204441|Rhodospirillales S MlrC C-terminus - - - - - - - - - - - - DUF1485,MlrC_C k59_65353_2 911045.PSE_0437 3.07e-46 163.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQQH@28211|Alphaproteobacteria 28211|Alphaproteobacteria E ABC-type dipeptide transport system periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_428187_1 472759.Nhal_2825 2.71e-100 308.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1WX2I@135613|Chromatiales 135613|Chromatiales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_846065_1 181119.XP_005532262.1 1.13e-16 82.0 COG1104@1|root,KOG1549@2759|Eukaryota,38E7D@33154|Opisthokonta,3BC56@33208|Metazoa,3CWJG@33213|Bilateria,481PR@7711|Chordata,492J8@7742|Vertebrata,4GQI8@8782|Aves 33208|Metazoa E Cysteine desulfurase, mitochondrial NFS1 GO:0000096,GO:0000959,GO:0000963,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006396,GO:0006399,GO:0006400,GO:0006464,GO:0006520,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0018282,GO:0018283,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031071,GO:0031163,GO:0031974,GO:0031981,GO:0032324,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0036211,GO:0042278,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0065003,GO:0070013,GO:0070525,GO:0070900,GO:0070903,GO:0071704,GO:0071840,GO:0072521,GO:0090304,GO:0090407,GO:0090646,GO:0140053,GO:1900864,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1990221 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_741343_2 107636.JQNK01000009_gene1995 7.83e-36 127.0 COG1475@1|root,COG1475@2|Bacteria,1R5VN@1224|Proteobacteria 1224|Proteobacteria K ParB-like nuclease domain ybdM - - - - - - - - - - - ParBc k59_324345_1 511062.GU3_03365 5.23e-74 242.0 COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,1RPGF@1236|Gammaproteobacteria,1Y57E@135624|Aeromonadales 135624|Aeromonadales V MatE - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_65362_1 5762.XP_002680445.1 3.39e-38 143.0 COG0205@1|root,KOG2440@2759|Eukaryota 2759|Eukaryota G 6-phosphofructokinase activity - - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_639926_1 1380346.JNIH01000001_gene4067 4.2e-117 353.0 COG1274@1|root,COG1274@2|Bacteria,2GJH3@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009607,GO:0009987,GO:0009991,GO:0010106,GO:0016020,GO:0019725,GO:0030003,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0043207,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0071944,GO:0075136,GO:0098771 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_532425_1 290315.Clim_2069 7.58e-22 100.0 COG2989@1|root,COG2989@2|Bacteria,1FEJK@1090|Chlorobi 1090|Chlorobi S PFAM Peptidoglycan-binding domain 1 protein - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_796897_1 686340.Metal_3282 1.05e-75 233.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,1RRVZ@1236|Gammaproteobacteria,1XEBI@135618|Methylococcales 135618|Methylococcales S Belongs to the BI1 family - - - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_796897_2 247490.KSU1_C1637 4.09e-35 126.0 COG2930@1|root,COG2930@2|Bacteria 2|Bacteria S regulation of ruffle assembly - - - - - - - - - - - - Ysc84 k59_4827_1 568817.SCc_454 2.37e-26 99.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,4040W@613|Serratia 1236|Gammaproteobacteria K Cold-shock protein cspC GO:0001072,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031554,GO:0031564,GO:0043242,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051087,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0060567,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_4827_2 1031711.RSPO_c02847 8.19e-25 102.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1K3N3@119060|Burkholderiaceae 28216|Betaproteobacteria JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_1421089_1 580340.Tlie_0146 6.51e-23 97.4 COG0406@1|root,COG0406@2|Bacteria,3TAZ5@508458|Synergistetes 2|Bacteria G phosphoglycerate mutase family gpmB - 3.1.3.3,3.1.3.73,5.4.2.12 ko:K02226,ko:K15634,ko:K15640,ko:K22305 ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00122 R00582,R01518,R04594,R11173 RC00017,RC00536 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_1421089_2 1341151.ASZU01000008_gene1394 2.96e-44 160.0 COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,4HAR3@91061|Bacilli,27B8M@186824|Thermoactinomycetaceae 91061|Bacilli J Arginyl tRNA synthetase N terminal dom argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_271620_2 555778.Hneap_2084 1.13e-30 120.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1WWQE@135613|Chromatiales 135613|Chromatiales J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_271627_4 999550.KI421507_gene2198 3.26e-08 57.0 COG0593@1|root,COG0863@1|root,COG0593@2|Bacteria,COG0863@2|Bacteria,1R7RR@1224|Proteobacteria,2TS8Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the N(4) N(6)-methyltransferase family - - - - - - - - - - - - N6_N4_Mtase k59_584740_2 1273538.G159_12985 2.19e-06 51.2 COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,4HC85@91061|Bacilli,26DS6@186818|Planococcaceae 91061|Bacilli M Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins prsA - 5.2.1.8 ko:K01802,ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3,Trigger_C k59_1266674_1 1095769.CAHF01000005_gene1469 3.39e-115 351.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,2VKWB@28216|Betaproteobacteria 28216|Betaproteobacteria J elongation factor G - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_271629_1 436308.Nmar_1577 1.11e-113 341.0 COG0459@1|root,arCOG01257@2157|Archaea,41T11@651137|Thaumarchaeota 651137|Thaumarchaeota O TCP-1/cpn60 chaperonin family - - - ko:K22447 - - - - ko00000,ko03110 - - - Cpn60_TCP1 k59_898542_1 1121946.AUAX01000020_gene3142 9.15e-22 99.0 COG1524@1|root,COG1524@2|Bacteria,2HH0Q@201174|Actinobacteria,4DAQP@85008|Micromonosporales 201174|Actinobacteria S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phage_holin_4_2,Phosphodiest k59_1055178_1 105559.Nwat_0845 8.23e-170 488.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1WVZV@135613|Chromatiales 135613|Chromatiales P PFAM Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_1474744_2 448385.sce2299 2.95e-16 79.3 COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria,2YWKI@29|Myxococcales 28221|Deltaproteobacteria H Pyridoxal-dependent decarboxylase conserved domain - - - - - - - - - - - - Pyridoxal_deC k59_271641_1 870187.Thini_0378 5.49e-10 60.5 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,45ZUA@72273|Thiotrichales 72273|Thiotrichales M gamma-glutamyltranspeptidase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1521768_1 1137799.GZ78_03040 2.82e-58 200.0 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,1RN9B@1236|Gammaproteobacteria,1XID3@135619|Oceanospirillales 135619|Oceanospirillales C carnitine dehydratase - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_219284_1 1121405.dsmv_2612 6.56e-66 212.0 COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,42Q93@68525|delta/epsilon subdivisions,2WKAA@28221|Deltaproteobacteria,2MJ2T@213118|Desulfobacterales 28221|Deltaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 5.1.1.20 ko:K19802 - - R10938 RC03309 ko00000,ko01000 - - - MR_MLE_C,MR_MLE_N k59_114121_1 485915.Dret_2428 4.02e-26 106.0 29UFS@1|root,30FSN@2|Bacteria,1RDI2@1224|Proteobacteria,42RWP@68525|delta/epsilon subdivisions,2WNB3@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_532480_2 218491.ECA0976 3.9e-73 230.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,1MQ8K@122277|Pectobacterium 1236|Gammaproteobacteria L A G-specific adenine glycosylase mutY GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_481021_1 1187851.A33M_3783 2.49e-45 164.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TSME@28211|Alphaproteobacteria,3FDMG@34008|Rhodovulum 28211|Alphaproteobacteria E Gamma-glutamyltranspeptidase MA20_16750 - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1266706_1 261292.Nit79A3_3277 1.74e-28 112.0 COG0664@1|root,COG0664@2|Bacteria,1RK3F@1224|Proteobacteria,2VT59@28216|Betaproteobacteria,371N4@32003|Nitrosomonadales 28216|Betaproteobacteria K Cyclic nucleotide-binding - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_1266706_2 56780.SYN_00775 2.39e-43 149.0 COG2197@1|root,COG2197@2|Bacteria,1RARA@1224|Proteobacteria,43B1G@68525|delta/epsilon subdivisions,2X5U5@28221|Deltaproteobacteria,2MRK4@213462|Syntrophobacterales 28221|Deltaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_949988_1 926556.Echvi_2071 0.00061 48.1 COG4105@1|root,COG4105@2|Bacteria,4NJ5A@976|Bacteroidetes,47MWE@768503|Cytophagia 976|Bacteroidetes S TIGRFAM Outer membrane assembly lipoprotein YfiO yfiO - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_532491_1 1161401.ASJA01000010_gene1439 3.35e-80 252.0 COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1MVH7@1224|Proteobacteria,2TRNA@28211|Alphaproteobacteria,43Z0S@69657|Hyphomonadaceae 28211|Alphaproteobacteria KL DNA methylase - - - - - - - - - - - - N6_N4_Mtase,ParBc k59_1521780_1 1227349.C170_26427 3.43e-14 76.6 COG0412@1|root,COG0412@2|Bacteria,1UI42@1239|Firmicutes,4ISCQ@91061|Bacilli,26VMD@186822|Paenibacillaceae 91061|Bacilli Q Alpha beta hydrolase yndB - - - - - - - - - - - Abhydrolase_5 k59_65449_1 1158292.JPOE01000002_gene2284 2.48e-109 337.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,1KN75@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain coxL - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1158984_1 290397.Adeh_1613 6.32e-83 270.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2YUBZ@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdA1 - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC k59_898573_1 593750.Metfor_0263 1.54e-24 104.0 COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,2NAKS@224756|Methanomicrobia 224756|Methanomicrobia C V-type ATPase 116kDa subunit family atpI-2 - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_898573_2 290397.Adeh_1198 3.32e-16 72.8 COG0636@1|root,COG0636@2|Bacteria,1N5D3@1224|Proteobacteria,438SF@68525|delta/epsilon subdivisions,2WY87@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM H transporting two-sector ATPase C subunit - - - ko:K02124 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_C k59_428274_1 1131269.AQVV01000018_gene1931 7.35e-11 62.4 COG1005@1|root,COG1005@2|Bacteria 2|Bacteria C quinone binding nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_532497_1 472759.Nhal_2659 1.5e-109 326.0 COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,1RQ15@1236|Gammaproteobacteria,1X0JQ@135613|Chromatiales 135613|Chromatiales S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - - k59_1576885_1 1458357.BG58_17875 6.37e-56 178.0 COG3293@1|root,COG3293@2|Bacteria,1PE1I@1224|Proteobacteria,2VSHY@28216|Betaproteobacteria,1K7K9@119060|Burkholderiaceae 28216|Betaproteobacteria L Putative transposase of IS4/5 family (DUF4096) - - - - - - - - - - - - DDE_Tnp_1_2,DUF4096 k59_1629935_1 56780.SYN_02987 4.18e-138 404.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,42S30@68525|delta/epsilon subdivisions,2WQ5S@28221|Deltaproteobacteria,2MRTS@213462|Syntrophobacterales 28221|Deltaproteobacteria L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_846165_1 436308.Nmar_0084 2.79e-39 140.0 COG0702@1|root,arCOG03015@2157|Archaea,41T19@651137|Thaumarchaeota 651137|Thaumarchaeota M NAD(P)H-binding - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - NAD_binding_10 k59_1214264_1 1192034.CAP_5178 1.12e-103 318.0 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria 28221|Deltaproteobacteria C malic protein domain protein - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic k59_376271_1 671143.DAMO_0962 1.19e-09 65.5 COG0845@1|root,COG0845@2|Bacteria,2NP3Y@2323|unclassified Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cebB - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - DUF3347,HlyD_D23,HlyD_D4,YtkA k59_1474802_1 1223521.BBJX01000002_gene2859 2.43e-59 187.0 COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,2VNRT@28216|Betaproteobacteria,4AGHP@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM cytochrome c oxidase subunit II - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2 k59_1474802_2 1244869.H261_01547 1.92e-12 67.0 COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2U068@28211|Alphaproteobacteria,2JWSB@204441|Rhodospirillales 204441|Rhodospirillales C Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 k59_1159005_1 240015.ACP_0897 4.93e-40 143.0 COG0130@1|root,COG0130@2|Bacteria,3Y3PG@57723|Acidobacteria,2JIGA@204432|Acidobacteriia 204432|Acidobacteriia J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB_C_2,TruB_N k59_4856_2 1205680.CAKO01000010_gene3788 8.02e-47 162.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TTGJ@28211|Alphaproteobacteria,2JQ2F@204441|Rhodospirillales 204441|Rhodospirillales E Aspartate tyrosine aromatic aminotransferase - - - - - - - - - - - - Aminotran_1_2 k59_741446_1 1120953.AUBH01000004_gene3125 1.57e-59 204.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,46AXN@72275|Alteromonadaceae 1236|Gammaproteobacteria P Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG k59_1159008_2 331869.BAL199_06614 7e-72 233.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_797041_1 1380394.JADL01000007_gene4476 8.31e-51 181.0 COG0672@1|root,COG0672@2|Bacteria,1MX1M@1224|Proteobacteria,2TU8Z@28211|Alphaproteobacteria,2JRT0@204441|Rhodospirillales 204441|Rhodospirillales P Iron permease FTR1 family - - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - FTR1 k59_481084_1 204669.Acid345_1270 2.05e-31 122.0 COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia 204432|Acidobacteriia Q Flavin containing amine oxidoreductase - - - - - - - - - - - - NAD_binding_8 k59_481084_2 935565.JAEM01000016_gene1461 1.13e-27 107.0 COG0346@1|root,COG0346@2|Bacteria,1N4MJ@1224|Proteobacteria,2UDJP@28211|Alphaproteobacteria,2PYVX@265|Paracoccus 28211|Alphaproteobacteria E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase k59_584825_1 1122951.ATUE01000006_gene1177 4.18e-23 99.8 COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,1RR1C@1236|Gammaproteobacteria,3NIWT@468|Moraxellaceae 1236|Gammaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1629966_2 536019.Mesop_1363 1.18e-12 69.3 COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,2TVK6@28211|Alphaproteobacteria,43J10@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E N-formylglutamate amidohydrolase - - - - - - - - - - - - FGase k59_271708_1 1283300.ATXB01000001_gene1292 3.12e-92 284.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,1XE3Q@135618|Methylococcales 135618|Methylococcales U PFAM Type II secretion system F domain pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_1421220_2 1514668.JOOA01000002_gene1029 6.72e-12 64.3 COG0317@1|root,COG0317@2|Bacteria,1VC5K@1239|Firmicutes,24NB3@186801|Clostridia,3WK1V@541000|Ruminococcaceae 186801|Clostridia KT HD domain - - - - - - - - - - - - HD_4 k59_219349_1 279714.FuraDRAFT_3773 4.75e-07 55.1 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2VMU1@28216|Betaproteobacteria,2KS2V@206351|Neisseriales 206351|Neisseriales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_324460_1 1205680.CAKO01000040_gene771 1.93e-81 248.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,2JPE4@204441|Rhodospirillales 204441|Rhodospirillales E COG0411 ABC-type branched-chain amino acid transport systems, ATPase component - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_324460_2 391937.NA2_13657 7.41e-152 447.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2TSSI@28211|Alphaproteobacteria,43GSS@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I AMP-binding enzyme fadD3 - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_532542_1 1229909.NSED_03000 1.93e-34 122.0 COG1528@1|root,arCOG01095@2157|Archaea 2157|Archaea P PFAM Ferritin, Dps family protein - - 1.16.3.2 ko:K02217 - - - - ko00000,ko01000 - - - Ferritin k59_384070_1 305900.GV64_02780 1.5e-27 112.0 COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,1RQDH@1236|Gammaproteobacteria,1XH4P@135619|Oceanospirillales 135619|Oceanospirillales P Phosphate-binding protein - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_278265_1 1049564.TevJSym_ag01030 5.19e-63 207.0 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1J5DY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_697554_1 309801.trd_1825 5.41e-69 226.0 COG1012@1|root,COG1012@2|Bacteria,2G5JE@200795|Chloroflexi,27XTS@189775|Thermomicrobia 189775|Thermomicrobia C Aldehyde dehydrogenase family - - 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_956339_1 314231.FP2506_18634 4.13e-33 120.0 COG3791@1|root,COG3791@2|Bacteria,1PSHP@1224|Proteobacteria,2VANA@28211|Alphaproteobacteria,2PK6T@255475|Aurantimonadaceae 28211|Alphaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_278273_1 1479238.JQMZ01000001_gene1278 1.15e-18 89.0 COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria,43XP4@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Phosphoribosyl transferase domain comF - - - - - - - - - - - Pribosyltran k59_121894_1 926550.CLDAP_33140 1.79e-46 167.0 COG3533@1|root,COG3533@2|Bacteria,2G5YC@200795|Chloroflexi 200795|Chloroflexi S Beta-L-arabinofuranosidase, GH127 - - - - - - - - - - - - Glyco_hydro_127 k59_1008782_1 436308.Nmar_1793 3.19e-133 388.0 COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_1275236_1 880073.Calab_3321 1.69e-68 231.0 COG3696@1|root,COG3696@2|Bacteria,2NNKZ@2323|unclassified Bacteria 2|Bacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K07787,ko:K15726 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_1275238_1 290512.Paes_0917 3.32e-164 475.0 COG1883@1|root,COG1883@2|Bacteria,1FEQK@1090|Chlorobi 1090|Chlorobi C PFAM Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit - - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta k59_747682_1 1232410.KI421414_gene2921 4.41e-12 67.4 COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,42MEY@68525|delta/epsilon subdivisions,2WM0F@28221|Deltaproteobacteria,43TV0@69541|Desulfuromonadales 28221|Deltaproteobacteria M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_747682_2 1463854.JOHT01000008_gene5731 9.62e-15 72.4 COG3467@1|root,COG3467@2|Bacteria,2IIAS@201174|Actinobacteria 201174|Actinobacteria S pyridoxamine 5-phosphate - - - - - - - - - - - - Putative_PNPOx,Pyridox_ox_2 k59_1008801_1 314278.NB231_17243 8.63e-13 64.7 COG2835@1|root,COG2835@2|Bacteria,1P6IM@1224|Proteobacteria,1SV7D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Trm112p-like protein - - - - - - - - - - - - Trm112p k59_1008801_2 1323663.AROI01000010_gene3326 1.09e-60 200.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E glutamine synthetase - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_1526067_1 926556.Echvi_4426 1.13e-06 53.1 COG1538@1|root,COG1538@2|Bacteria,4NF4X@976|Bacteroidetes,47KE9@768503|Cytophagia 976|Bacteroidetes MU PFAM Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1526067_2 1279009.ADICEAN_02063 1.03e-20 87.8 COG1309@1|root,COG1309@2|Bacteria,4NQ99@976|Bacteroidetes,47QGN@768503|Cytophagia 976|Bacteroidetes K PFAM Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1164157_1 330214.NIDE4176 1.43e-77 241.0 COG1587@1|root,COG1587@2|Bacteria 2|Bacteria H uroporphyrinogen-III synthase activity hemD - 2.1.1.107,4.2.1.75 ko:K01719,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4,Trans_reg_C k59_805424_1 1232683.ADIMK_0341 7.37e-73 231.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,464K0@72275|Alteromonadaceae 1236|Gammaproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0050511,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 iSFV_1184.SFV_0083,iSF_1195.SF0087,iSFxv_1172.SFxv_0091,iS_1188.S0089 Glyco_tran_28_C,Glyco_transf_28 k59_805424_2 667632.KB890188_gene3310 1.93e-24 102.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria,1K0M1@119060|Burkholderiaceae 28216|Betaproteobacteria D Peptidoglycan polymerase that is essential for cell division ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_225649_1 1111479.AXAR01000008_gene2279 1.67e-40 149.0 COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,4HACR@91061|Bacilli 91061|Bacilli M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_852546_1 268747.Q58LL9_BPPRS 1.82e-76 248.0 4QDQJ@10239|Viruses,4QXIE@35237|dsDNA viruses no RNA stage,4QQ8V@28883|Caudovirales,4QK6R@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_805429_1 330214.NIDE1279 2.1e-94 284.0 COG1131@1|root,COG1131@2|Bacteria 2|Bacteria V ATPase activity ccmA - 3.6.3.7 ko:K01990,ko:K09697 ko02010,ko02020,map02010,map02020 M00253,M00254 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.115 - - ABC_tran k59_1113871_1 203122.Sde_3677 2.8e-49 168.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,464IR@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641 DFP,Flavoprotein k59_1113871_2 519989.ECTPHS_00999 2.23e-104 307.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,1WXFP@135613|Chromatiales 135613|Chromatiales L Belongs to the UPF0758 family - - - ko:K03630 - - - - ko00000 - - - RadC k59_278316_1 1459636.NTE_02862 3.68e-62 207.0 arCOG00144@1|root,arCOG00144@2157|Archaea 2157|Archaea S Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_384145_1 316067.Geob_0374 3.32e-65 203.0 COG2018@1|root,COG2018@2|Bacteria,1RDN5@1224|Proteobacteria,42S13@68525|delta/epsilon subdivisions,2WNKB@28221|Deltaproteobacteria,43T83@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM Roadblock LC7 family protein mglB - - - - - - - - - - - Robl_LC7 k59_648384_1 247634.GPB2148_1774 1.76e-14 73.9 COG1028@1|root,COG1028@2|Bacteria,1R6NY@1224|Proteobacteria,1S0VU@1236|Gammaproteobacteria,1JAJQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C IQR COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_648384_2 471854.Dfer_4584 1.84e-10 59.7 COG0537@1|root,COG0537@2|Bacteria,4NQ4X@976|Bacteroidetes,47Q95@768503|Cytophagia 976|Bacteroidetes FG HIT family hydrolase hinT - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_591134_2 82654.Pse7367_2646 2.97e-14 68.6 COG3791@1|root,COG3791@2|Bacteria,1G5S8@1117|Cyanobacteria,1HBJ3@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_956380_1 1126627.BAWE01000005_gene4737 0.000274 42.4 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TT2P@28211|Alphaproteobacteria,3JWSW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Elongator protein 3 MiaB NifB - - - - - - - - - - - - Radical_SAM k59_852555_1 1229909.NSED_08965 8.09e-81 240.0 COG0864@1|root,arCOG01008@2157|Archaea,41SQM@651137|Thaumarchaeota 651137|Thaumarchaeota K Ribbon-helix-helix protein, copG family - - - ko:K07722 - - - - ko00000,ko03000 - - - NikR_C,RHH_1 k59_852555_2 436308.Nmar_1684 1.16e-12 67.8 arCOG08795@1|root,arCOG08795@2157|Archaea 2157|Archaea C copper ion binding - - - - - - - - - - - - - k59_330795_1 1333998.M2A_2795 2.48e-89 273.0 COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2TSWA@28211|Alphaproteobacteria,4BSFK@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Alcohol dehydrogenase GroES-like domain MA20_31690 - - - - - - - - - - - ADH_N,ADH_zinc_N k59_1320589_1 1469245.JFBG01000021_gene1196 1.71e-45 162.0 COG0151@1|root,COG0151@2|Bacteria,1QTYI@1224|Proteobacteria 1224|Proteobacteria F ATP-grasp domain - - - - - - - - - - - - ATP-grasp_4 k59_591137_2 671143.DAMO_2318 5.09e-48 166.0 COG0019@1|root,COG0019@2|Bacteria,2NNQK@2323|unclassified Bacteria 2|Bacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.1.129,3.4.16.4,4.1.1.20 ko:K01586,ko:K05366 ko00300,ko00550,ko01100,ko01110,ko01120,ko01130,ko01230,ko01501,map00300,map00550,map01100,map01110,map01120,map01130,map01230,map01501 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000,ko01003,ko01011 - GT51 iLJ478.TM1517 Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_384157_1 570268.ANBB01000022_gene5289 5.94e-12 60.5 COG1141@1|root,COG1141@2|Bacteria,2GT1Y@201174|Actinobacteria,4EKQX@85012|Streptosporangiales 201174|Actinobacteria C 4Fe-4S single cluster domain of Ferredoxin I fdxD_2 - - ko:K05337 - - - - ko00000 - - - Fer4_13,Fer4_15 k59_384157_2 1206725.BAFU01000091_gene4718 6.54e-58 190.0 COG2070@1|root,COG2070@2|Bacteria,2GKGT@201174|Actinobacteria,4FW5B@85025|Nocardiaceae 201174|Actinobacteria S Nitronate monooxygenase - - - - - - - - - - - - NMO k59_1637112_1 1266914.ATUK01000014_gene2034 1.1e-07 59.3 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1WWY6@135613|Chromatiales 135613|Chromatiales U Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 k59_225682_1 1239962.C943_01807 1.14e-39 143.0 COG0346@1|root,COG0346@2|Bacteria,4NGE0@976|Bacteroidetes,47KJP@768503|Cytophagia 976|Bacteroidetes E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K15975 - - - - ko00000 - - - Glyoxalase k59_1275313_1 318424.EU78_11230 1.01e-16 80.9 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2GNII@201174|Actinobacteria,23687@1762|Mycobacteriaceae 201174|Actinobacteria C Dehydrogenase E1 component - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_1275313_2 1279017.AQYJ01000018_gene776 1.4e-16 79.3 COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RQ57@1236|Gammaproteobacteria,469X9@72275|Alteromonadaceae 1236|Gammaproteobacteria G Fructose-bisphosphate aldolase class-I alf1 - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic k59_385172_1 330214.NIDE1727 2.68e-11 63.2 COG0484@1|root,COG0484@2|Bacteria,3J0A7@40117|Nitrospirae 40117|Nitrospirae O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_385172_2 999541.bgla_1g05690 4.54e-11 65.1 COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,2VJS2@28216|Betaproteobacteria,1K1P3@119060|Burkholderiaceae 28216|Betaproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_806454_1 264462.Bd0554 3.95e-18 79.3 COG0727@1|root,COG0727@2|Bacteria,1N3F5@1224|Proteobacteria,42T7I@68525|delta/epsilon subdivisions,2MU1A@213481|Bdellovibrionales,2WPNZ@28221|Deltaproteobacteria 213481|Bdellovibrionales S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_226365_1 1282360.ABAC460_18945 4.21e-73 234.0 COG0673@1|root,COG0673@2|Bacteria,1QSNV@1224|Proteobacteria,2TUMB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_1221807_1 870187.Thini_3774 6.01e-90 283.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,463NI@72273|Thiotrichales 72273|Thiotrichales C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4_20,Fer4_7,Pyr_redox_2 k59_649367_1 445683.E3SJP7_9CAUD 3.71e-115 334.0 4QAUS@10239|Viruses 10239|Viruses S flavin adenine dinucleotide binding - - - - - - - - - - - - - k59_1430396_1 1279019.ARQK01000060_gene2229 6.52e-148 429.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1WVX6@135613|Chromatiales 135613|Chromatiales G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_1430396_2 580332.Slit_1883 2.51e-25 98.2 COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,2VVQJ@28216|Betaproteobacteria,44W01@713636|Nitrosomonadales 28216|Betaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsB - - ko:K05589 - - - - ko00000,ko03036 - - - DivIC k59_748499_1 1232437.KL661983_gene3542 6.6e-38 138.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,43DRR@68525|delta/epsilon subdivisions,2X70U@28221|Deltaproteobacteria,2MJ6E@213118|Desulfobacterales 28221|Deltaproteobacteria E PFAM Cys Met metabolism metY-3 - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_539441_1 59374.Fisuc_0585 3.45e-27 110.0 COG0688@1|root,COG0688@2|Bacteria 2|Bacteria I phosphatidylethanolamine metabolic process psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_957055_1 436308.Nmar_1391 1.14e-44 159.0 COG1498@1|root,arCOG01923@2157|Archaea,41SY9@651137|Thaumarchaeota 651137|Thaumarchaeota J NOSIC (NUC001) domain - - - ko:K14564 ko03008,map03008 - - - ko00000,ko00001,ko03009 - - - Nop k59_1484121_1 85643.Tmz1t_3669 2.74e-52 167.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,2VR79@28216|Betaproteobacteria,2KWGN@206389|Rhodocyclales 206389|Rhodocyclales J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_1584237_1 1085623.GNIT_3422 2.86e-84 271.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,4656T@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG2217 Cation transport ATPase copA - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_1584237_2 1397527.Q670_00935 5.45e-35 124.0 COG4633@1|root,COG4633@2|Bacteria,1N1UQ@1224|Proteobacteria,1S9HX@1236|Gammaproteobacteria,1XPEX@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - - - - - - - - - - Cupredoxin_1 k59_435793_1 511.JT27_08265 4.06e-26 103.0 COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2VID5@28216|Betaproteobacteria,3T2KQ@506|Alcaligenaceae 28216|Betaproteobacteria S ATPase (AAA - - - ko:K06923 - - - - ko00000 - - - DUF815 k59_435793_2 1268635.Loa_01659 3.22e-59 190.0 COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,1RNPQ@1236|Gammaproteobacteria,1JCVQ@118969|Legionellales 118969|Legionellales F Phosphoribosyl transferase domain ppt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_435793_3 1123401.JHYQ01000003_gene2154 9.95e-53 173.0 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,1RS0S@1236|Gammaproteobacteria,460HP@72273|Thiotrichales 72273|Thiotrichales F Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine - - 2.4.2.44 ko:K19696 ko00270,ko01100,map00270,map01100 - R09668 RC00063 ko00000,ko00001,ko01000 - - - Abhydrolase_3,PNP_UDP_1 k59_1375405_1 472759.Nhal_3529 1.05e-52 171.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,1S5VU@1236|Gammaproteobacteria,1WYA2@135613|Chromatiales 135613|Chromatiales J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_1375405_2 1286106.MPL1_05519 2.37e-40 134.0 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,1S8R8@1236|Gammaproteobacteria,460WE@72273|Thiotrichales 72273|Thiotrichales J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_539455_1 1379270.AUXF01000001_gene2299 2.14e-86 265.0 COG0714@1|root,COG0714@2|Bacteria,1ZUSV@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_905820_1 1123518.ARWI01000001_gene1438 5.33e-25 102.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria 1236|Gammaproteobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_74732_1 1168067.JAGP01000001_gene1019 1.98e-88 280.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,45ZN9@72273|Thiotrichales 72273|Thiotrichales P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_331560_1 1333998.M2A_1693 1.01e-112 338.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TTRD@28211|Alphaproteobacteria,4BT82@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_539457_1 1382230.ASAP_1915 1.13e-29 117.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2TTIX@28211|Alphaproteobacteria,2JPBF@204441|Rhodospirillales 204441|Rhodospirillales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_596921_2 83406.HDN1F_33500 4.29e-19 80.9 COG4634@1|root,COG4634@2|Bacteria,1NAN6@1224|Proteobacteria,1SCBD@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_753431_2 1266925.JHVX01000004_gene1244 6.77e-15 78.2 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,373U8@32003|Nitrosomonadales 28216|Betaproteobacteria C NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_441422_1 1229909.NSED_00110 1.66e-100 301.0 COG1903@1|root,arCOG04383@2157|Archaea,41S70@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A cbiD - 2.1.1.195 ko:K02188 ko00860,ko01100,map00860,map01100 - R07773 RC00003,RC02051 ko00000,ko00001,ko01000 - - - CbiD k59_1283185_1 264198.Reut_B3721 6.9e-23 99.4 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VIFS@28216|Betaproteobacteria,1K04V@119060|Burkholderiaceae 28216|Betaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1283185_2 72019.SARC_07231T0 1.12e-16 82.0 COG0515@1|root,KOG1095@2759|Eukaryota 2759|Eukaryota KLT transmembrane receptor protein tyrosine kinase activity - - - - - - - - - - - - LRR_8,Pkinase,Pkinase_Tyr k59_1324827_2 5111.M1VU75 0.000753 48.1 COG1028@1|root,KOG1204@2759|Eukaryota,39WU3@33154|Opisthokonta,3NZ6I@4751|Fungi,3QR10@4890|Ascomycota,211Z4@147550|Sordariomycetes,3TGZT@5125|Hypocreales,3G3RE@34397|Clavicipitaceae 4751|Fungi Q Enoyl-(Acyl carrier protein) reductase - GO:0003674,GO:0003824,GO:0004757,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0016651,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0031224,GO:0034311,GO:0034312,GO:0034641,GO:0042558,GO:0042559,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0050664,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.320 ko:K16216 - - - - ko00000,ko01000 - - - adh_short k59_1437035_1 244447.XP_008324506.1 2.27e-96 296.0 COG0056@1|root,KOG1353@2759|Eukaryota,38ERH@33154|Opisthokonta,3BCEE@33208|Metazoa,3CU79@33213|Bilateria,489CP@7711|Chordata,497ZQ@7742|Vertebrata,49U3W@7898|Actinopterygii 33208|Metazoa C ATP synthase, H transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle ATP5A1 GO:0000166,GO:0000275,GO:0001936,GO:0001937,GO:0003674,GO:0003824,GO:0005102,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005753,GO:0005759,GO:0005886,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006164,GO:0006629,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006839,GO:0006996,GO:0007005,GO:0007006,GO:0007007,GO:0008144,GO:0008150,GO:0008152,GO:0008285,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0010594,GO:0010595,GO:0010632,GO:0010634,GO:0010876,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016043,GO:0016310,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0019866,GO:0019915,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0022900,GO:0030334,GO:0030335,GO:0030554,GO:0031090,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032879,GO:0032991,GO:0033036,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0040012,GO:0040017,GO:0042127,GO:0042287,GO:0042288,GO:0042407,GO:0042623,GO:0042625,GO:0042626,GO:0042776,GO:0043167,GO:0043168,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043492,GO:0043531,GO:0043532,GO:0043535,GO:0043536,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044769,GO:0045121,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0046907,GO:0046933,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050678,GO:0050680,GO:0050789,GO:0050790,GO:0050794,GO:0051179,GO:0051234,GO:0051235,GO:0051239,GO:0051240,GO:0051270,GO:0051272,GO:0051338,GO:0051641,GO:0051649,GO:0055085,GO:0055086,GO:0055114,GO:0061024,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0097159,GO:0097367,GO:0098589,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0098805,GO:0098857,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902600,GO:1902769,GO:1990542,GO:2000145,GO:2000147 - ko:K02132 ko00190,ko01100,ko04714,ko05010,ko05012,ko05016,map00190,map01100,map04714,map05010,map05012,map05016 M00158 - - ko00000,ko00001,ko00002 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1067553_1 1122176.KB903532_gene2668 5.29e-42 155.0 COG1574@1|root,COG1574@2|Bacteria,4NFMV@976|Bacteroidetes,1IPIC@117747|Sphingobacteriia 976|Bacteroidetes S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_1643964_2 160488.PP_1931 6.17e-67 217.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1S01K@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_544139_1 1121937.AUHJ01000012_gene2746 9.26e-67 223.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,465J9@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0038 Chloride channel protein EriC eriC - - ko:K03281 - - - - ko00000 2.A.49 - - Voltage_CLC k59_81499_1 1455608.JDTH01000011_gene2273 2.4e-82 265.0 COG3653@1|root,arCOG00690@2157|Archaea,2XVS0@28890|Euryarchaeota,23T5C@183963|Halobacteria 183963|Halobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 k59_81499_2 525368.HMPREF0591_5216 1.15e-09 60.5 COG2062@1|root,COG2062@2|Bacteria,2GJ0I@201174|Actinobacteria,239P1@1762|Mycobacteriaceae 201174|Actinobacteria T Phosphohistidine phosphatase SixA sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_1324839_1 187272.Mlg_2849 7.39e-82 253.0 COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,1S296@1236|Gammaproteobacteria,1X2D7@135613|Chromatiales 135613|Chromatiales L Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_1324839_2 225937.HP15_3019 8.33e-39 139.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,464C7@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0530 Ca2 Na antiporter Z012_08255 - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_656194_1 118161.KB235922_gene3424 1.56e-46 161.0 COG0491@1|root,COG1141@1|root,COG0491@2|Bacteria,COG1141@2|Bacteria,1G3D1@1117|Cyanobacteria,3VIAS@52604|Pleurocapsales 1117|Cyanobacteria C 4Fe-4S single cluster domain of Ferredoxin I - - - - - - - - - - - - Fer4_13 k59_1119469_1 471857.Svir_27300 1.13e-55 196.0 COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4DX9G@85010|Pseudonocardiales 201174|Actinobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_1490854_1 1469245.JFBG01000038_gene1817 1.32e-95 301.0 COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,1T214@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - DUF3306,Fer4,Fer4_10,Fer4_6,Fer4_7 k59_961874_1 330214.NIDE0846 5.95e-84 257.0 COG0192@1|root,COG0192@2|Bacteria,3J0A4@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_497379_1 1340493.JNIF01000004_gene1115 1.67e-23 99.8 COG5012@1|root,COG5012@2|Bacteria 2|Bacteria T cobalamin binding ycgE - - ko:K22491 - - - - ko00000,ko03000 - - - B12-binding,B12-binding_2,MerR_1 k59_1168480_1 1236973.JCM9157_161 2.66e-11 63.9 COG0607@1|root,COG0607@2|Bacteria,1VES3@1239|Firmicutes,4I3NV@91061|Bacilli,1ZI44@1386|Bacillus 91061|Bacilli P rhodanese - - - - - - - - - - - - Rhodanese k59_1168480_2 1121373.KB903623_gene2340 4.52e-08 56.2 COG0730@1|root,COG0730@2|Bacteria,4NFWP@976|Bacteroidetes,47KYB@768503|Cytophagia 976|Bacteroidetes S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_284050_1 1182590.BN5_00225 8.76e-89 274.0 COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,1RQDX@1236|Gammaproteobacteria,1YFPY@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_1380160_1 439235.Dalk_3143 9.52e-31 114.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,42U00@68525|delta/epsilon subdivisions,2WQD4@28221|Deltaproteobacteria,2MKKC@213118|Desulfobacterales 28221|Deltaproteobacteria U PFAM Biopolymer transport protein ExbD TolR tolR - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_1530321_1 330214.NIDE0759 4.27e-74 236.0 COG0771@1|root,COG0771@2|Bacteria,3J0HT@40117|Nitrospirae 40117|Nitrospirae M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_544170_1 1370125.AUWT01000005_gene3158 1.27e-84 268.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,237Q8@1762|Mycobacteriaceae 201174|Actinobacteria C CoA-transferase family III - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_81527_1 1183438.GKIL_4436 2.44e-23 101.0 COG1091@1|root,COG1091@2|Bacteria,1G3IE@1117|Cyanobacteria 1117|Cyanobacteria M dTDP-4-dehydrorhamnose reductase rmlD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_910852_1 1177154.Y5S_01714 8.43e-56 194.0 COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,1S157@1236|Gammaproteobacteria,1XQ5M@135619|Oceanospirillales 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16 k59_1120302_2 1286171.EAL2_c22220 3.28e-105 327.0 COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,247U2@186801|Clostridia,25UR2@186806|Eubacteriaceae 186801|Clostridia D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_657297_2 1279017.AQYJ01000028_gene2039 7.08e-18 80.5 COG1225@1|root,COG1225@2|Bacteria,1RER0@1224|Proteobacteria,1S4K1@1236|Gammaproteobacteria,46AJ1@72275|Alteromonadaceae 1236|Gammaproteobacteria O Redoxin - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_657297_3 756272.Plabr_1566 1.01e-20 92.0 COG0025@1|root,COG0025@2|Bacteria 2|Bacteria P sodium:proton antiporter activity - - - - - - - - - - - - Na_H_Exchanger k59_1530985_1 420324.KI912043_gene4011 8.97e-40 152.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,1JR57@119045|Methylobacteriaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_1325520_1 555778.Hneap_0391 7.33e-14 76.3 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1WWAA@135613|Chromatiales 135613|Chromatiales O peptidylprolyl isomerase - - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,SurA_N_3 k59_1015545_1 1347086.CCBA010000004_gene4459 2.46e-33 130.0 COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,4HCST@91061|Bacilli,1ZCPN@1386|Bacillus 91061|Bacilli T Sigma-54 interaction domain atoC - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1015545_2 113395.AXAI01000002_gene5219 1.95e-19 88.6 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1 k59_129724_1 1279017.AQYJ01000029_gene3667 2.02e-113 335.0 COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,1RP4C@1236|Gammaproteobacteria,464ZF@72275|Alteromonadaceae 1236|Gammaproteobacteria S Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons dhmA - 3.8.1.5 ko:K01563 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_129724_2 1245469.S58_67050 2.91e-48 164.0 COG0625@1|root,COG0625@2|Bacteria,1Q9ND@1224|Proteobacteria,2TT22@28211|Alphaproteobacteria,3JX9Z@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Glutathione S-transferase, C-terminal domain - - - - - - - - - - - - GST_C_2,GST_N_3 k59_498495_1 1229909.NSED_09475 2e-106 318.0 COG0531@1|root,arCOG00009@2157|Archaea,41SXX@651137|Thaumarchaeota 651137|Thaumarchaeota E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_814374_1 402777.KB235904_gene3192 1.4e-37 146.0 COG0642@1|root,COG2199@1|root,COG3290@1|root,COG2205@2|Bacteria,COG3290@2|Bacteria,COG3706@2|Bacteria,1G13T@1117|Cyanobacteria,1H77Q@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_8,PAS_9,Response_reg k59_498497_1 1033802.SSPSH_002593 4.79e-141 423.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,1RPM6@1236|Gammaproteobacteria 1236|Gammaproteobacteria P transport of potassium into the cell kup GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_657322_1 1121935.AQXX01000109_gene480 3.13e-75 250.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1XHSN@135619|Oceanospirillales 135619|Oceanospirillales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_1491951_1 6500.XP_005110674.1 7.23e-10 61.6 COG1618@1|root,2QVJ8@2759|Eukaryota,38FT1@33154|Opisthokonta,3BGUB@33208|Metazoa,3CSDG@33213|Bilateria 33208|Metazoa O nucleotide phosphatase activity, acting on free nucleotides NTPCR - 3.6.1.15 ko:K06928 ko00230,ko00730,ko01100,map00230,map00730,map01100 - R00086,R00615 RC00002 ko00000,ko00001,ko01000 - - - NTPase_1 k59_1590108_1 671143.DAMO_0962 2.06e-41 149.0 COG0845@1|root,COG0845@2|Bacteria,2NP3Y@2323|unclassified Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cebB - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - DUF3347,HlyD_D23,HlyD_D4,YtkA k59_1590108_2 1125863.JAFN01000001_gene1438 5.9e-17 80.1 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_1169147_1 596154.Alide2_1844 2.26e-29 121.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2VMR3@28216|Betaproteobacteria,4AD85@80864|Comamonadaceae 28216|Betaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_704185_1 1234664.AMRO01000027_gene1345 6.24e-41 139.0 COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,4HINN@91061|Bacilli,1WGCQ@129337|Geobacillus 91061|Bacilli J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_1169151_1 765911.Thivi_3845 6.14e-76 238.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,1RPRD@1236|Gammaproteobacteria,1X29Z@135613|Chromatiales 135613|Chromatiales C PFAM Alcohol dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N_2 k59_498513_1 338963.Pcar_0129 1.49e-57 214.0 COG3209@1|root,COG4932@1|root,COG3209@2|Bacteria,COG4932@2|Bacteria,1MVV1@1224|Proteobacteria,42R71@68525|delta/epsilon subdivisions,2WMW5@28221|Deltaproteobacteria,43SWS@69541|Desulfuromonadales 28221|Deltaproteobacteria M RHS protein - - - - - - - - - - - - DUF4150,RHS,RHS_repeat k59_1491972_1 584708.Apau_0548 3.61e-91 288.0 COG0855@1|root,COG0855@2|Bacteria,3TAC8@508458|Synergistetes 508458|Synergistetes H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_284954_1 420324.KI912061_gene6197 1.79e-61 213.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,1JR57@119045|Methylobacteriaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,Abhydrolase_1,Guanylate_cyc,TPR_4 k59_657358_1 706587.Desti_1791 6.39e-05 51.6 COG0726@1|root,COG3391@1|root,COG0726@2|Bacteria,COG3391@2|Bacteria,1QWRQ@1224|Proteobacteria 1224|Proteobacteria M 6-phosphogluconolactonase activity - - - - - - - - - - - - ASH,Abhydrolase_3,Cadherin-like,Cadherin_3,TIG,VCBS k59_1169161_1 62928.azo0765 2.03e-58 201.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2VHVB@28216|Betaproteobacteria,2KV63@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1531023_2 1122212.AULO01000007_gene2536 8.6e-30 115.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria 1224|Proteobacteria M Glycosyl transferase group 1 MA20_36900 - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_337283_1 999541.bgla_1g14780 1.62e-35 127.0 COG0625@1|root,COG0625@2|Bacteria,1RC4Y@1224|Proteobacteria,2VW3S@28216|Betaproteobacteria,1K51R@119060|Burkholderiaceae 28216|Betaproteobacteria H Belongs to the GST superfamily gstF - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - AHSA1,GST_C,GST_N,GST_N_3 k59_337283_2 864073.HFRIS_019915 6.22e-21 93.2 COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2VNGN@28216|Betaproteobacteria,4776R@75682|Oxalobacteraceae 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_859314_1 269799.Gmet_1849 9.58e-18 84.7 COG1192@1|root,COG1192@2|Bacteria,1NPCB@1224|Proteobacteria,42Y7J@68525|delta/epsilon subdivisions,2WUHN@28221|Deltaproteobacteria,43T7Q@69541|Desulfuromonadales 28221|Deltaproteobacteria D NUBPL iron-transfer P-loop NTPase - - - - - - - - - - - - AAA_31 k59_859314_2 1236542.BALM01000014_gene1203 5.69e-23 95.5 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,2Q9N9@267890|Shewanellaceae 1236|Gammaproteobacteria M Activates KDO8N (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in the Shewanella genus kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_754356_1 1256908.HMPREF0373_00102 2.49e-14 78.2 COG1404@1|root,COG1404@2|Bacteria,1TQK9@1239|Firmicutes,25B1U@186801|Clostridia,25V8C@186806|Eubacteriaceae 186801|Clostridia O Belongs to the peptidase S8 family cspBA - - - - - - - - - - - Peptidase_S8 k59_82659_1 472759.Nhal_1845 5.78e-61 211.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,LysM k59_1380878_1 747.DR93_1126 7.83e-53 171.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,1S4H7@1236|Gammaproteobacteria,1Y8HA@135625|Pasteurellales 135625|Pasteurellales K Belongs to the Fur family fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_129781_1 1333998.M2A_0743 4.62e-106 311.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,2TUXR@28211|Alphaproteobacteria,4BQ9D@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3 k59_129781_2 1207063.P24_15836 9.13e-58 200.0 COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,2U1SX@28211|Alphaproteobacteria,2JRJ2@204441|Rhodospirillales 204441|Rhodospirillales N ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux k59_1068471_1 436308.Nmar_1727 8.59e-92 287.0 COG1782@1|root,arCOG00543@2157|Archaea,41T05@651137|Thaumarchaeota 651137|Thaumarchaeota S RNA-metabolising metallo-beta-lactamase - - - ko:K07041 - - - - ko00000 - - - Beta-Casp,KH_7,Lactamase_B_6,RMMBL k59_82665_1 498761.HM1_0096 7.97e-41 149.0 COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,247XK@186801|Clostridia 186801|Clostridia E O-acetylhomoserine metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_1284397_2 595494.Tola_0731 1.33e-25 103.0 COG3926@1|root,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,1RRB6@1236|Gammaproteobacteria,1Y64N@135624|Aeromonadales 135624|Aeromonadales S Predicted Peptidoglycan domain - - - - - - - - - - - - Glyco_hydro_108,PG_binding_3 k59_1284397_3 1304275.C41B8_05368 1.77e-25 109.0 28S81@1|root,2ZEJD@2|Bacteria,1RCNN@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_657388_1 1123368.AUIS01000001_gene1868 1.69e-128 373.0 COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,1S11K@1236|Gammaproteobacteria,2NBQA@225057|Acidithiobacillales 225057|Acidithiobacillales E DAHP synthetase I family - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_82679_1 36331.EPrPI00000015782 1.02e-29 118.0 COG0114@1|root,KOG4308@1|root,KOG1317@2759|Eukaryota,KOG4308@2759|Eukaryota,1MEIS@121069|Pythiales 121069|Pythiales C Leucine Rich repeat - - - - - - - - - - - - LRR_6 k59_82679_2 223926.28809981 2.14e-13 71.6 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,1XV4P@135623|Vibrionales 135623|Vibrionales M Outer membrane efflux protein VPA1579 - - - - - - - - - - - OEP k59_1228878_1 910314.HMPREF9220_0743 3.92e-30 124.0 COG5108@1|root,COG5108@2|Bacteria 2|Bacteria K dna-directed rna polymerase - - 2.7.7.6 ko:K08309,ko:K10908,ko:K21313 - - - - ko00000,ko01000,ko01011,ko03029,ko03200 - GH23 - RNA_pol,RPOL_N k59_1075939_1 1397527.Q670_09700 2.47e-17 84.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,1XPNY@135619|Oceanospirillales 135619|Oceanospirillales E COG2303 Choline dehydrogenase and related flavoproteins - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_1075939_2 429009.Adeg_0027 1.04e-19 86.7 COG0517@1|root,COG0517@2|Bacteria,1V0XU@1239|Firmicutes,24I2P@186801|Clostridia,42GMX@68295|Thermoanaerobacterales 186801|Clostridia S Domain in cystathionine beta-synthase and other proteins. acuB - - ko:K04767 - - - - ko00000 - - - ACT,CBS k59_1500514_1 1265503.KB905163_gene2318 4.36e-33 127.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,2Q5V7@267889|Colwelliaceae 1236|Gammaproteobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_1075954_1 1449076.JOOE01000004_gene197 3.89e-12 62.4 COG0346@1|root,COG0346@2|Bacteria,1RH8G@1224|Proteobacteria,2UAQ3@28211|Alphaproteobacteria,2KD77@204457|Sphingomonadales 204457|Sphingomonadales E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_1075954_2 876044.IMCC3088_2543 1.66e-25 107.0 COG5285@1|root,COG5285@2|Bacteria,1PUNA@1224|Proteobacteria,1RR1S@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG5285 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - - - - - - - - - - PhyH k59_919483_1 498211.CJA_3288 3.81e-60 197.0 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1FG7C@10|Cellvibrio 1236|Gammaproteobacteria D Phage integrase, N-terminal SAM-like domain xerC GO:0000150,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0042150,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0071139,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_551262_1 105559.Nwat_2048 9.29e-30 119.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1WWH2@135613|Chromatiales 135613|Chromatiales L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA recB - 3.1.11.5,3.6.4.12 ko:K03582,ko:K16898 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_508574_2 396588.Tgr7_0563 4.96e-16 76.6 COG1416@1|root,COG1416@2|Bacteria,1MYMK@1224|Proteobacteria,1SD2F@1236|Gammaproteobacteria,1X1AM@135613|Chromatiales 135613|Chromatiales K AntiSigma factor - - - ko:K09004 - - - - ko00000 - - - - k59_1022517_1 1123309.AQYB01000033_gene1085 2.74e-15 77.0 COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,4H9QH@91061|Bacilli 91061|Bacilli L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_239346_1 745014.OMB55_00015150 3e-52 176.0 COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,1RZ34@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q taurine catabolism dioxygenase tauD - 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_138767_1 471852.Tcur_3608 2.88e-07 54.3 COG0616@1|root,COG0616@2|Bacteria,2HQDG@201174|Actinobacteria,4EHD6@85012|Streptosporangiales 201174|Actinobacteria OU Peptidase family S49 sppA - - ko:K04773,ko:K04774 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_138767_2 941449.dsx2_0953 2.05e-84 259.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WKXU@28221|Deltaproteobacteria,2M80I@213115|Desulfovibrionales 28221|Deltaproteobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_14609_1 713586.KB900536_gene2659 9.41e-107 317.0 COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3 k59_711389_1 948565.AFFP02000024_gene123 3.27e-21 92.4 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1Y7IE@135625|Pasteurellales 135625|Pasteurellales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_711389_2 349124.Hhal_1654 3.42e-29 110.0 COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1WYJU@135613|Chromatiales 135613|Chromatiales S Modulates RecA activity recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX k59_1237976_1 1131269.AQVV01000012_gene2599 3.12e-96 288.0 COG0005@1|root,COG0005@2|Bacteria 2|Bacteria F purine-nucleoside phosphorylase activity mtnP - 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_604590_1 330214.NIDE0246 1.08e-31 120.0 COG1472@1|root,COG1472@2|Bacteria,3J0MK@40117|Nitrospirae 40117|Nitrospirae G Glycosyl hydrolase family 3 N terminal domain - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_604590_2 330214.NIDE0245 4.46e-173 494.0 COG0260@1|root,COG0260@2|Bacteria,3J0X7@40117|Nitrospirae 40117|Nitrospirae E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_92298_1 519989.ECTPHS_03914 3.28e-53 172.0 COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,1S6WA@1236|Gammaproteobacteria,1WXPI@135613|Chromatiales 135613|Chromatiales F phosphoribosyltransferase pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran k59_92298_2 1423775.BAMN01000004_gene1439 2.44e-10 61.6 COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,4HH04@91061|Bacilli,3F6NI@33958|Lactobacillaceae 91061|Bacilli J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yrrK GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_1387447_1 713586.KB900536_gene1866 2.2e-61 198.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1RNEH@1236|Gammaproteobacteria,1X01K@135613|Chromatiales 135613|Chromatiales P TIGRFAM nitrate ABC transporter, ATPase subunits C and D - - - ko:K15578 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16.1 - - ABC_tran k59_1387447_2 395493.BegalDRAFT_1385 0.000379 43.1 COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,1RPP1@1236|Gammaproteobacteria,4600G@72273|Thiotrichales 72273|Thiotrichales P transporter, permease - - - ko:K15577 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - BPD_transp_1 k59_1537353_2 1121896.JMLU01000001_gene934 0.000877 43.5 COG1327@1|root,COG1327@2|Bacteria,4NHXI@976|Bacteroidetes,1HYJ8@117743|Flavobacteriia,2NUTK@237|Flavobacterium 976|Bacteroidetes K Restriction endonuclease - - - - - - - - - - - - ATP-cone,Mrr_cat k59_508609_2 349124.Hhal_1059 1.77e-47 157.0 COG0494@1|root,COG0494@2|Bacteria,1MYSK@1224|Proteobacteria,1SB8U@1236|Gammaproteobacteria,1WZ0K@135613|Chromatiales 135613|Chromatiales L Belongs to the Nudix hydrolase family - - 3.6.1.17 ko:K01518 ko00230,ko00240,map00230,map00240 - R00184,R00969,R01232,R02805 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_508609_3 395494.Galf_2067 3.07e-44 155.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2VKXU@28216|Betaproteobacteria,44UZP@713636|Nitrosomonadales 28216|Betaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1537356_1 582744.Msip34_0587 8.49e-25 104.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KKYV@206350|Nitrosomonadales 206350|Nitrosomonadales NU TIGRFAM type IV-A pilus assembly ATPase PilB - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_970023_2 706587.Desti_0899 1.35e-43 144.0 COG2329@1|root,COG2329@2|Bacteria,1NDM8@1224|Proteobacteria 1224|Proteobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ydhR k59_970023_3 218491.ECA2965 1.64e-25 103.0 COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,1RPIT@1236|Gammaproteobacteria,1MQ76@122277|Pectobacterium 1236|Gammaproteobacteria M mandelate racemase muconate lactonizing - - 4.2.1.6 ko:K01684 ko00052,ko01100,ko01120,map00052,map01100,map01120 M00552 R03033 RC00543 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_1446061_1 1216007.AOPM01000080_gene1165 3.43e-12 67.4 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,2Q1W3@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_14619_2 1493508.A0A0E3F8Y6_9CAUD 1.98e-25 95.9 4QFPH@10239|Viruses,4QPQA@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1238029_1 330214.NIDE0864 1.14e-32 121.0 COG1127@1|root,COG1127@2|Bacteria,3J0J2@40117|Nitrospirae 40117|Nitrospirae Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_1238029_2 247490.KSU1_C0176 3.08e-22 94.0 COG0767@1|root,COG0767@2|Bacteria,2J03N@203682|Planctomycetes 203682|Planctomycetes Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_451837_1 1121405.dsmv_3570 2.07e-95 290.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria,2MHM9@213118|Desulfobacterales 28221|Deltaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_508643_2 1160718.SU9_27759 3.69e-56 183.0 COG2141@1|root,COG2141@2|Bacteria,2GMMJ@201174|Actinobacteria 201174|Actinobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_824593_1 1125863.JAFN01000001_gene2831 3.96e-05 44.7 2CJPW@1|root,32SAH@2|Bacteria,1NAJ3@1224|Proteobacteria,42W32@68525|delta/epsilon subdivisions,2WQGF@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_138829_1 1089551.KE386572_gene1278 4.3e-06 49.7 COG1682@1|root,COG1682@2|Bacteria,1N0X3@1224|Proteobacteria,2U57D@28211|Alphaproteobacteria,4BT6P@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria GM ABC-2 type transporter - - - ko:K09690 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC2_membrane k59_138829_2 234267.Acid_4641 3.05e-23 97.4 COG1134@1|root,COG1134@2|Bacteria,3Y756@57723|Acidobacteria 57723|Acidobacteria GM Wzt C-terminal domain - - - ko:K09691 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC_tran,Wzt_C k59_970045_1 1237149.C900_04893 2.07e-09 63.9 COG2989@1|root,COG2989@2|Bacteria,4NH3J@976|Bacteroidetes,47MU1@768503|Cytophagia 976|Bacteroidetes T L,D-transpeptidase catalytic domain - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_92345_2 1242864.D187_007986 1.68e-37 143.0 COG1994@1|root,COG1994@2|Bacteria,1PC66@1224|Proteobacteria,433UK@68525|delta/epsilon subdivisions,2XA3T@28221|Deltaproteobacteria,2YWAR@29|Myxococcales 28221|Deltaproteobacteria S Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 k59_1537380_1 1121405.dsmv_3736 1.53e-87 262.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,42QAM@68525|delta/epsilon subdivisions,2WM04@28221|Deltaproteobacteria 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100,1.1.1.36 ko:K00023,ko:K00059 ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212 M00083,M00373,M00572 R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00103,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_239410_1 1123392.AQWL01000007_gene878 1.43e-69 233.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2VKF8@28216|Betaproteobacteria,1KSFY@119069|Hydrogenophilales 119069|Hydrogenophilales V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_397556_1 398767.Glov_0589 1.25e-19 93.6 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria 28221|Deltaproteobacteria T histidine kinase HAMP region domain protein phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like k59_345762_1 292415.Tbd_0297 1.66e-25 104.0 COG3307@1|root,COG3307@2|Bacteria,1PX0E@1224|Proteobacteria,2VKT7@28216|Betaproteobacteria,1KSY0@119069|Hydrogenophilales 119069|Hydrogenophilales M O-antigen ligase like membrane protein - - - - - - - - - - - - Wzy_C k59_667520_1 933262.AXAM01000033_gene1626 2.77e-78 246.0 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,42PC9@68525|delta/epsilon subdivisions,2WKA4@28221|Deltaproteobacteria,2MJ22@213118|Desulfobacterales 28221|Deltaproteobacteria F Na dependent nucleoside transporter - - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_1537395_2 391625.PPSIR1_08501 8.41e-05 45.8 COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,431JD@68525|delta/epsilon subdivisions,2WXPQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria O COG0760 Parvulin-like peptidyl-prolyl isomerase - - - - - - - - - - - - Rotamase_2 k59_552426_2 903818.KI912268_gene646 3.17e-07 51.2 COG0372@1|root,COG0372@2|Bacteria,3Y32J@57723|Acidobacteria 57723|Acidobacteria C Belongs to the citrate synthase family - - - - - - - - - - - - Citrate_synt k59_1446110_1 452638.Pnec_0521 6.22e-24 95.9 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2VQ06@28216|Betaproteobacteria,1K02A@119060|Burkholderiaceae 28216|Betaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_1446110_2 553385.JEMF01000018_gene886 1.06e-11 67.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1XHF6@135619|Oceanospirillales 135619|Oceanospirillales M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_667543_1 324925.Ppha_0524 5.86e-08 57.8 COG0451@1|root,COG0451@2|Bacteria 2|Bacteria GM ADP-glyceromanno-heptose 6-epimerase activity - - 4.2.1.46,5.1.3.2 ko:K01710,ko:K01784 ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00362,M00632,M00793 R00291,R02984,R06513 RC00289,RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_667543_2 1116472.MGMO_153c00040 1.85e-61 204.0 COG4992@1|root,COG4992@2|Bacteria,1R6U9@1224|Proteobacteria,1RMRF@1236|Gammaproteobacteria,1XEQV@135618|Methylococcales 135618|Methylococcales E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.13 ko:K00819 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R00667 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_667544_1 1122611.KB903946_gene766 3.87e-71 244.0 COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4EGYX@85012|Streptosporangiales 201174|Actinobacteria E Bacterial NAD-glutamate dehydrogenase gdh - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_451913_2 665571.STHERM_c08920 4.41e-39 142.0 COG0275@1|root,COG0275@2|Bacteria,2J6DH@203691|Spirochaetes 203691|Spirochaetes J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_1332102_1 697282.Mettu_3683 3.02e-59 191.0 COG3658@1|root,COG3658@2|Bacteria,1PCRS@1224|Proteobacteria,1S5C0@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM cytochrome B561 - - - - - - - - - - - - Ni_hydr_CYTB k59_711483_1 765911.Thivi_1973 5.15e-17 82.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales 135613|Chromatiales U sulphate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_824667_1 290397.Adeh_1905 1.15e-39 137.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,437B2@68525|delta/epsilon subdivisions,2X2FR@28221|Deltaproteobacteria,2Z0QW@29|Myxococcales 28221|Deltaproteobacteria L HNH endonuclease - - - - - - - - - - - - HNH_5 k59_824667_2 224324.aq_1031 3.39e-23 102.0 COG1921@1|root,COG1921@2|Bacteria,2G3ND@200783|Aquificae 200783|Aquificae J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA GO:0003674,GO:0003824,GO:0004125,GO:0005488,GO:0005515,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - - Se-cys_synth_N,SelA k59_138899_1 234267.Acid_1319 9.95e-28 111.0 COG3547@1|root,COG3547@2|Bacteria,3Y52I@57723|Acidobacteria 57723|Acidobacteria L transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_667554_1 1336233.JAEH01000011_gene2891 1.62e-11 68.6 2C852@1|root,32YB2@2|Bacteria,1N9HY@1224|Proteobacteria,1SCRT@1236|Gammaproteobacteria,2QA0N@267890|Shewanellaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4136) - - - - - - - - - - - - DUF4136 k59_1537417_1 323261.Noc_0376 2.83e-59 207.0 COG0784@1|root,COG2199@1|root,COG2200@1|root,COG0784@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1WWNV@135613|Chromatiales 135613|Chromatiales T PFAM EAL domain - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg k59_1238124_1 227377.CBU_1431 1.97e-20 86.7 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria,1JENK@118969|Legionellales 118969|Legionellales J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_1238124_2 765914.ThisiDRAFT_1474 1.15e-105 332.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales 135613|Chromatiales J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_920826_2 1284686.HMPREF1630_03225 3.47e-13 65.5 COG0695@1|root,COG0695@2|Bacteria,1VI6J@1239|Firmicutes,24QNT@186801|Clostridia,22HZ2@1570339|Peptoniphilaceae 186801|Clostridia O Glutaredoxin - - - - - - - - - - - - Glutaredoxin k59_920826_3 1556290.A0A0A0RM00_9CAUD 1.28e-36 137.0 4QAXQ@10239|Viruses,4QRFY@28883|Caudovirales,4QM52@10699|Siphoviridae 10699|Siphoviridae S ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor - - - - - - - - - - - - - k59_1022631_1 713587.THITH_01805 5.87e-12 70.9 COG0834@1|root,COG4623@1|root,COG0834@2|Bacteria,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1WXYV@135613|Chromatiales 135613|Chromatiales M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella - - - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_866475_1 420662.Mpe_A1639 7.55e-39 135.0 COG0789@1|root,COG0789@2|Bacteria,1RGX6@1224|Proteobacteria,2VSD1@28216|Betaproteobacteria,1KMHA@119065|unclassified Burkholderiales 28216|Betaproteobacteria K MerR, DNA binding cueR - - ko:K19591,ko:K19592 - M00768,M00769 - - ko00000,ko00002,ko01504,ko03000 - - - MerR,MerR-DNA-bind,MerR_1 k59_552468_1 1198232.CYCME_0756 5.79e-23 90.1 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,1S973@1236|Gammaproteobacteria,460ZF@72273|Thiotrichales 72273|Thiotrichales J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_552468_2 545276.KB898725_gene705 6.57e-96 282.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,1WW32@135613|Chromatiales 135613|Chromatiales J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_552468_3 1002339.HMPREF9373_0874 3.19e-06 47.0 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,1S62N@1236|Gammaproteobacteria,3NNIJ@468|Moraxellaceae 1236|Gammaproteobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_604685_1 93220.LV28_17995 1.61e-33 123.0 COG4525@1|root,COG4525@2|Bacteria,1QTUA@1224|Proteobacteria,2VIKA@28216|Betaproteobacteria,1K2BN@119060|Burkholderiaceae 28216|Betaproteobacteria P Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system tauB - 3.6.3.36 ko:K10831 ko00920,ko02010,map00920,map02010 M00435 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.17.1,3.A.1.17.4 - - ABC_tran k59_604685_2 1469245.JFBG01000014_gene2037 2.12e-164 464.0 COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,1RQ0A@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC-type nitrate sulfonate bicarbonate transport system permease component - - - ko:K15552 ko00920,ko02010,map00920,map02010 M00435 - - ko00000,ko00001,ko00002,ko02000 3.A.1.17.1,3.A.1.17.4 - - BPD_transp_1 k59_1597111_1 1230343.CANP01000008_gene919 2.22e-24 102.0 COG2242@1|root,COG2242@2|Bacteria,1PEB4@1224|Proteobacteria,1T5ZE@1236|Gammaproteobacteria,1JFKT@118969|Legionellales 118969|Legionellales H protein methyltransferase activity - - - - - - - - - - - - - k59_1603332_1 388467.A19Y_0615 1.2e-11 67.4 COG0438@1|root,COG0438@2|Bacteria,1G2T9@1117|Cyanobacteria,1H82P@1150|Oscillatoriales 1117|Cyanobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_1603332_2 933262.AXAM01000032_gene674 1e-09 60.1 COG0515@1|root,COG0515@2|Bacteria,1R47Q@1224|Proteobacteria,42WMT@68525|delta/epsilon subdivisions,2WRXI@28221|Deltaproteobacteria,2MM0W@213118|Desulfobacterales 28221|Deltaproteobacteria KLT Lipopolysaccharide kinase (Kdo/WaaP) family - - - - - - - - - - - - Kdo k59_459763_1 338966.Ppro_2747 2.17e-36 137.0 COG1597@1|root,COG1597@2|Bacteria,1PV0P@1224|Proteobacteria,42XZR@68525|delta/epsilon subdivisions,2WTF1@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM diacylglycerol kinase catalytic region - - - - - - - - - - - - DAGK_cat k59_560376_1 43354.JOIJ01000014_gene867 1.67e-99 305.0 COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria,4DZE9@85010|Pseudonocardiales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1338951_1 493475.GARC_4436 1.98e-24 103.0 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,1SZZ0@1236|Gammaproteobacteria 1236|Gammaproteobacteria V MatE - - - - - - - - - - - - MatE k59_1544722_1 1322246.BN4_12764 1.78e-41 153.0 COG1073@1|root,COG1073@2|Bacteria,1QUMG@1224|Proteobacteria,43BM5@68525|delta/epsilon subdivisions,2X6ZB@28221|Deltaproteobacteria,2M9BQ@213115|Desulfovibrionales 28221|Deltaproteobacteria S alpha beta - - - - - - - - - - - - - k59_519759_2 1122211.JMLW01000012_gene329 1.01e-33 122.0 COG0589@1|root,COG0589@2|Bacteria,1RI97@1224|Proteobacteria,1SDH1@1236|Gammaproteobacteria,1XR0U@135619|Oceanospirillales 135619|Oceanospirillales T Universal stress protein family - - - - - - - - - - - - Usp k59_1394334_1 1329516.JPST01000005_gene1421 3.78e-67 223.0 COG1351@1|root,COG1351@2|Bacteria,1TVJ1@1239|Firmicutes,4HDJE@91061|Bacilli,27CRU@186824|Thermoactinomycetaceae 91061|Bacilli F Thymidylate synthase complementing protein - - - - - - - - - - - - Thy1 k59_1137958_1 1121374.KB891575_gene837 2.42e-45 163.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_768881_1 1282876.BAOK01000001_gene2540 1.64e-62 219.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,4BPAA@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_611899_1 395493.BegalDRAFT_2457 5.89e-79 244.0 COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,1SYJC@1236|Gammaproteobacteria,4607A@72273|Thiotrichales 72273|Thiotrichales EP Binding-protein-dependent transport system inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1338956_1 446469.Sked_23910 2.89e-08 60.5 COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria 201174|Actinobacteria H Folylpolyglutamate synthase folC GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv2447c Mur_ligase_C,Mur_ligase_M k59_1603341_1 395493.BegalDRAFT_0638 7.02e-131 409.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,4600V@72273|Thiotrichales 72273|Thiotrichales E Vitamin B12 dependent methionine synthase, activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_1452949_1 314724.BT0179 3.19e-22 100.0 COG0486@1|root,COG0486@2|Bacteria,2J5GU@203691|Spirochaetes 203691|Spirochaetes J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_404956_1 1336243.JAEA01000017_gene588 1.98e-06 48.5 COG3703@1|root,COG3703@2|Bacteria,1RIGV@1224|Proteobacteria,2UA8X@28211|Alphaproteobacteria,1JVGA@119045|Methylobacteriaceae 28211|Alphaproteobacteria P PFAM AIG2 family protein - - - - - - - - - - - - AIG2_2,GGACT k59_1394357_1 585530.HMPREF0183_0642 6.11e-06 53.5 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily tetA - - ko:K08151,ko:K08153 - M00668,M00717 - - ko00000,ko00002,ko01504,ko02000 2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75,2.A.1.2.8 - - MFS_1,Sugar_tr k59_1305725_1 102129.Lepto7375DRAFT_0641 1.78e-38 143.0 COG1961@1|root,COG1961@2|Bacteria,1G266@1117|Cyanobacteria,1HEYW@1150|Oscillatoriales 1117|Cyanobacteria L Recombinase zinc beta ribbon domain - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom k59_1513091_1 472759.Nhal_1618 1.41e-134 381.0 COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,1RRAN@1236|Gammaproteobacteria,1X04F@135613|Chromatiales 135613|Chromatiales C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Fer4_7 k59_1513091_2 1123401.JHYQ01000007_gene542 0.0 1151.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,461JN@72273|Thiotrichales 72273|Thiotrichales C Molybdopterin oxidoreductase Fe4S4 domain - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1666547_1 889378.Spiaf_2284 3.86e-65 204.0 COG0764@1|root,COG0764@2|Bacteria 2|Bacteria I 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity fabA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016863,GO:0019171,GO:0019752,GO:0032787,GO:0034017,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b0954,iB21_1397.B21_00965,iBWG_1329.BWG_0806,iE2348C_1286.E2348C_0940,iEC042_1314.EC042_1039,iECBD_1354.ECBD_2641,iECB_1328.ECB_00958,iECDH10B_1368.ECDH10B_1024,iECD_1391.ECD_00958,iECED1_1282.ECED1_0977,iECH74115_1262.ECH74115_1118,iECIAI1_1343.ECIAI1_0995,iECIAI39_1322.ECIAI39_2193,iECNA114_1301.ECNA114_1032,iECO103_1326.ECO103_1000,iECO111_1330.ECO111_1022,iECO26_1355.ECO26_1081,iECOK1_1307.ECOK1_1013,iECS88_1305.ECS88_0975,iECSF_1327.ECSF_0868,iECSP_1301.ECSP_1060,iECUMN_1333.ECUMN_1143,iECW_1372.ECW_m1064,iECs_1301.ECs1038,iEKO11_1354.EKO11_2876,iETEC_1333.ETEC_1024,iEcE24377_1341.EcE24377A_1068,iEcHS_1320.EcHS_A1063,iEcSMS35_1347.EcSMS35_2166,iEcolC_1368.EcolC_2642,iG2583_1286.G2583_1189,iJO1366.b0954,iJR904.b0954,iLF82_1304.LF82_0604,iSBO_1134.SBO_2277,iSDY_1059.SDY_0927,iSF_1195.SF0954,iSSON_1240.SSON_0958,iSbBS512_1146.SbBS512_E2362,iUMNK88_1353.UMNK88_1108,iWFL_1372.ECW_m1064,iY75_1357.Y75_RS04955,iZ_1308.Z1304,ic_1306.c1090 FabA k59_1666547_2 996306.SSUR61_1841 4.2e-18 82.8 COG0764@1|root,COG0764@2|Bacteria,1V6EX@1239|Firmicutes,4HGX1@91061|Bacilli,1WTGT@1307|Streptococcus suis 91061|Bacilli I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_1666547_3 616991.JPOO01000003_gene684 2.05e-12 67.0 COG0304@1|root,COG0304@2|Bacteria,4NDXP@976|Bacteroidetes,1HXYM@117743|Flavobacteriia,23G11@178469|Arenibacter 976|Bacteroidetes IQ Beta-ketoacyl synthase, C-terminal domain fabB - - - - - - - - - - - Ketoacyl-synt_C,ketoacyl-synt k59_18333_1 1121413.JMKT01000016_gene72 3.57e-36 140.0 COG2199@1|root,COG3290@1|root,COG3290@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42S7S@68525|delta/epsilon subdivisions,2WNFR@28221|Deltaproteobacteria,2M9XW@213115|Desulfovibrionales 28221|Deltaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,GGDEF,PAS,PAS_3,PAS_9,dCache_1 k59_1305730_1 1227457.C451_18873 6.26e-50 173.0 COG0183@1|root,arCOG01278@2157|Archaea,2XVM2@28890|Euryarchaeota,23TYT@183963|Halobacteria 183963|Halobacteria I COG0183 Acetyl-CoA acetyltransferase - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_1305730_2 1041522.MCOL_V203490 3.44e-40 147.0 COG2072@1|root,COG2072@2|Bacteria,2GKYU@201174|Actinobacteria,233FB@1762|Mycobacteriaceae 201174|Actinobacteria P Flavin-binding monooxygenase-like pamO GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016705,GO:0016709,GO:0016999,GO:0017000,GO:0017144,GO:0018130,GO:0044237,GO:0044249,GO:0046483,GO:0055114,GO:0071704,GO:1901334,GO:1901336,GO:1901360,GO:1901362,GO:1901576 1.14.13.170,1.14.13.171,1.14.13.22 ko:K03379,ko:K18091 ko00930,ko01120,ko01130,ko01220,map00930,map01120,map01130,map01220 M00819 R02231,R06622 RC00662,RC01550 ko00000,ko00001,ko00002,ko01000 - - - FMO-like,NAD_binding_8,Pyr_redox_2,Pyr_redox_3 k59_611926_2 1049564.TevJSym_bb00160 1.44e-61 195.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1J6DF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_404976_1 1499689.CCNN01000006_gene417 1.13e-12 68.2 COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,36EFA@31979|Clostridiaceae 186801|Clostridia J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 trmU - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_404976_2 875454.BAEW01000004_gene831 9.82e-27 110.0 COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,247IX@186801|Clostridia,22G4S@1570339|Peptoniphilaceae 186801|Clostridia J tRNA methylthiotransferase YqeV yqeV - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_768907_2 671143.DAMO_0039 3.25e-17 74.3 COG3350@1|root,COG3350@2|Bacteria 2|Bacteria T monooxygenase activity - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DJ-1_PfpI,YHS k59_519812_1 1380394.JADL01000001_gene2929 2.02e-45 159.0 COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,2JQSB@204441|Rhodospirillales 204441|Rhodospirillales C FAD dependent oxidoreductase - - - - - - - - - - - - FAD_binding_2 k59_1182782_1 1284352.AOIG01000011_gene1339 1.58e-23 100.0 COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,1TSNY@1239|Firmicutes,4HTP9@91061|Bacilli,26VST@186822|Paenibacillaceae 91061|Bacilli G Glycosyltransferase family 20 - - - - - - - - - - - - Glyco_transf_20,Trehalose_PPase k59_1182782_2 1192034.CAP_7615 3.06e-16 79.0 COG1964@1|root,COG1964@2|Bacteria,1QE02@1224|Proteobacteria,42M4B@68525|delta/epsilon subdivisions,2WJDI@28221|Deltaproteobacteria,2YZG3@29|Myxococcales 28221|Deltaproteobacteria S 4Fe-4S single cluster domain - - - ko:K06937 - - - - ko00000,ko01000 - - - Fer4_12,Fer4_14,Radical_SAM k59_189842_1 420324.KI912086_gene7328 8.17e-12 69.3 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,1JU3D@119045|Methylobacteriaceae 28211|Alphaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3,DUF1643 k59_977537_1 511062.GU3_14285 1.9e-07 53.9 COG0845@1|root,COG0845@2|Bacteria,1R4JA@1224|Proteobacteria,1RPS5@1236|Gammaproteobacteria,1Y5XT@135624|Aeromonadales 135624|Aeromonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_1030474_1 1122236.KB905143_gene217 5.56e-16 78.6 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VHPQ@28216|Betaproteobacteria,2KMAM@206350|Nitrosomonadales 206350|Nitrosomonadales E PFAM peptidase M3A and M3B thimet oligopeptidase F - - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_1030474_2 1122164.JHWF01000043_gene1429 5.84e-22 94.7 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria,1JC7X@118969|Legionellales 118969|Legionellales C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain gor - 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_678746_1 935840.JAEQ01000016_gene2184 1.39e-52 181.0 COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria 28211|Alphaproteobacteria EG Belongs to the IlvD Edd family MA20_16960 - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_519832_1 443143.GM18_4047 7.37e-05 47.0 COG1216@1|root,COG3216@1|root,COG1216@2|Bacteria,COG3216@2|Bacteria,1QVEM@1224|Proteobacteria,42NYG@68525|delta/epsilon subdivisions,2WIXP@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - DUF2062,Glycos_transf_2 k59_519832_2 90813.JQMT01000001_gene687 4.25e-60 192.0 COG1028@1|root,COG1028@2|Bacteria,1MUPY@1224|Proteobacteria,1RMCB@1236|Gammaproteobacteria,461PD@72273|Thiotrichales 72273|Thiotrichales IQ KR domain - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_719519_1 368407.Memar_2432 5.86e-73 236.0 COG1109@1|root,arCOG00767@2157|Archaea,2XVBA@28890|Euryarchaeota 28890|Euryarchaeota G Phosphoglucomutase phosphomannomutase alpha beta alpha domain I manB GO:0003674,GO:0003824,GO:0004615,GO:0016853,GO:0016866,GO:0016868 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1305763_1 526225.Gobs_2418 5.11e-69 224.0 COG0526@1|root,COG0526@2|Bacteria,2IET9@201174|Actinobacteria 201174|Actinobacteria CO Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - k59_1138014_1 1397666.RS24_01175 7.55e-29 115.0 COG0596@1|root,COG0596@2|Bacteria,1NU1Q@1224|Proteobacteria,2U3QC@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6,Biotin_lipoyl k59_874043_1 1265313.HRUBRA_00778 3.08e-14 70.1 2E4SV@1|root,32ZM7@2|Bacteria,1N8VN@1224|Proteobacteria,1S6AW@1236|Gammaproteobacteria,1J73R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Putative transmembrane protein (PGPGW) - - - - - - - - - - - - PGPGW k59_18352_1 1415778.JQMM01000001_gene1138 6.93e-05 44.3 COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria,1J4YC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U COG0811 Biopolymer transport proteins - - - - - - - - - - - - MotA_ExbB k59_302482_1 862514.HMPREF0623_0606 2.79e-57 198.0 COG1217@1|root,COG1217@2|Bacteria,1TQ5Y@1239|Firmicutes,4HAQ6@91061|Bacilli,3F3UK@33958|Lactobacillaceae 91061|Bacilli T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2 k59_1394404_1 314287.GB2207_11478 1.03e-47 160.0 COG0693@1|root,COG0693@2|Bacteria,1PR9W@1224|Proteobacteria,1S114@1236|Gammaproteobacteria,1J7K8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S intracellular protease amidase - - - - - - - - - - - - DJ-1_PfpI k59_1394404_2 247634.GPB2148_3487 7.39e-40 150.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_874048_1 644283.Micau_1305 9.02e-43 159.0 COG1052@1|root,COG1052@2|Bacteria,2I2RK@201174|Actinobacteria,4DAB1@85008|Micromonosporales 201174|Actinobacteria E D-isomer specific 2-hydroxyacid dehydrogenase serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_611980_1 444860.E3SJ73_9CAUD 2.77e-35 120.0 4QBJQ@10239|Viruses,4QXAN@35237|dsDNA viruses no RNA stage,4QPB7@28883|Caudovirales,4QKIF@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_611980_2 444878.E3SR92_9CAUD 2.96e-30 108.0 4QFPH@10239|Viruses,4QPQA@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_719557_2 1380356.JNIK01000019_gene459 1.26e-23 95.5 COG0835@1|root,COG0835@2|Bacteria,2IQJ0@201174|Actinobacteria,4ET76@85013|Frankiales 201174|Actinobacteria NT Two component signalling adaptor domain cheW - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_1513192_1 330214.NIDE1304 3.62e-55 194.0 COG0086@1|root,COG0086@2|Bacteria,3J0BT@40117|Nitrospirae 40117|Nitrospirae K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1667946_1 367737.Abu_1426 2.67e-14 75.5 COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,42NQ3@68525|delta/epsilon subdivisions,2YMRF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Ni Fe-hydrogenase, b-type cytochrome subunit hydC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Ni_hydr_CYTB k59_874984_1 1122212.AULO01000007_gene2490 6.07e-27 105.0 COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,1RNPQ@1236|Gammaproteobacteria,1XJQK@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_874984_2 1318628.MARLIPOL_00513 6.81e-17 79.7 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,1RNUB@1236|Gammaproteobacteria,464I7@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0668 Small-conductance mechanosensitive channel ynaI GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944 - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_1183612_1 1492922.GY26_12430 3.26e-41 145.0 COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,1J6CU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the DnaA family. HdA subfamily hda GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113 - ko:K10763 - - - - ko00000,ko03032 - - - Bac_DnaA k59_460838_1 1123377.AUIV01000005_gene1728 1.16e-40 153.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1X32B@135614|Xanthomonadales 135614|Xanthomonadales P COG2217 Cation transport ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_190924_1 797299.HALLA_18720 8.77e-52 184.0 COG0272@1|root,arCOG04754@2157|Archaea,2XTQT@28890|Euryarchaeota,23S29@183963|Halobacteria 183963|Halobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_102131_1 211586.SO_3551 3.22e-15 75.5 COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1SASQ@1236|Gammaproteobacteria,2Q9NP@267890|Shewanellaceae 1236|Gammaproteobacteria K PFAM sigma-70 region 2 domain protein - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_102131_2 266264.Rmet_4519 2.53e-113 343.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2VHFX@28216|Betaproteobacteria,1K32K@119060|Burkholderiaceae 28216|Betaproteobacteria J RNA-metabolising metallo-beta-lactamase - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_930554_1 1415780.JPOG01000001_gene3152 2.3e-85 265.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,1RNDU@1236|Gammaproteobacteria,1XABV@135614|Xanthomonadales 135614|Xanthomonadales I Thiolase, C-terminal domain - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_930554_2 1348657.M622_04425 8.41e-70 221.0 COG0778@1|root,COG0778@2|Bacteria 2|Bacteria C coenzyme F420-1:gamma-L-glutamate ligase activity - - - - - - - - - - - - Nitroreductase k59_303524_1 208439.AJAP_15650 1.95e-25 110.0 COG4733@1|root,COG4733@2|Bacteria,2GNV7@201174|Actinobacteria,4E4T7@85010|Pseudonocardiales 201174|Actinobacteria S Fibronectin type 3 domain - - - - - - - - - - - - fn3 k59_355585_1 1122604.JONR01000003_gene1427 4.4e-30 124.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,1X5V0@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_190974_1 608538.HTH_1172 1.28e-15 79.7 COG1180@1|root,COG1180@2|Bacteria,2G4U5@200783|Aquificae 200783|Aquificae C 4Fe-4S single cluster domain - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_521218_1 765913.ThidrDRAFT_1312 4.38e-23 94.4 COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,1S3XB@1236|Gammaproteobacteria,1WYGA@135613|Chromatiales 135613|Chromatiales F Nudix N-terminal - - - - - - - - - - - - NUDIX,Nudix_N_2 k59_521218_2 399795.CtesDRAFT_PD3115 6.2e-28 110.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,4ABGB@80864|Comamonadaceae 28216|Betaproteobacteria I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k59_773264_1 551275.KB899545_gene2766 4.5e-07 57.4 COG2223@1|root,COG2223@2|Bacteria,1QXGZ@1224|Proteobacteria,2TXA2@28211|Alphaproteobacteria,43ZCP@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Major Facilitator Superfamily - - - ko:K08177 - - - - ko00000,ko02000 2.A.1.11 - - MFS_1 k59_724197_1 981327.F925_00482 2.46e-66 217.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,3NIJV@468|Moraxellaceae 1236|Gammaproteobacteria P Ammonium Transporter Family amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_307459_1 436308.Nmar_0447 4.21e-30 110.0 arCOG08731@1|root,arCOG08731@2157|Archaea,41STT@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_307459_2 436308.Nmar_0448 7.09e-32 112.0 arCOG10525@1|root,arCOG10525@2157|Archaea,41SUR@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1091166_1 161156.JQKW01000013_gene136 7.14e-33 126.0 COG1180@1|root,COG1180@2|Bacteria,2GH8R@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C Elongator protein 3, MiaB family, Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Radical_SAM k59_359420_1 269799.Gmet_0883 1.68e-117 344.0 COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,42QC6@68525|delta/epsilon subdivisions,2WIRV@28221|Deltaproteobacteria 28221|Deltaproteobacteria GM 3-beta hydroxysteroid dehydrogenase/isomerase family arnA - 1.1.1.305,2.1.2.13 ko:K10011,ko:K12449 ko00520,ko01100,ko01503,map00520,map01100,map01503 M00721,M00761 R01384,R01386,R07658,R07660 RC00026,RC00508,RC01575,RC01811,RC01812 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase,Formyl_trans_C,Formyl_trans_N k59_934629_1 404589.Anae109_0195 4.4e-16 80.5 COG3138@1|root,COG3138@2|Bacteria,1MWHC@1224|Proteobacteria,42SUP@68525|delta/epsilon subdivisions,2WPBD@28221|Deltaproteobacteria,2YU07@29|Myxococcales 28221|Deltaproteobacteria E N-succinyltransferase beta subunit astA - 2.3.1.109 ko:K00673 ko00330,ko01100,map00330,map01100 - R00832 RC00004,RC00064 ko00000,ko00001,ko01000 - - - AstA k59_934629_2 1151061.CAJY01000016_gene393 0.00031 46.2 COG1012@1|root,COG1012@2|Bacteria,2GJ95@201174|Actinobacteria 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.99.10 ko:K22445 - - - - ko00000,ko01000 - - - Aldedh k59_1343682_1 1131269.AQVV01000001_gene1311 1.3e-26 110.0 COG0480@1|root,COG0480@2|Bacteria 2|Bacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA-1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1250514_1 913325.N799_13975 1.62e-33 132.0 COG3211@1|root,COG3211@2|Bacteria,1QY0R@1224|Proteobacteria,1S13A@1236|Gammaproteobacteria,1X5KR@135614|Xanthomonadales 135614|Xanthomonadales S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839,TAT_signal k59_1399149_1 1283284.AZUK01000001_gene1531 7.8e-110 329.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1Y3EK@135624|Aeromonadales 135624|Aeromonadales L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_195421_1 861299.J421_0777 2.79e-54 175.0 COG2258@1|root,COG2258@2|Bacteria 2|Bacteria C MOSC domain - - - - - - - - - - - - MOSC k59_359458_1 520709.F985_02058 1.55e-28 115.0 COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,1RSFF@1236|Gammaproteobacteria,3NIX6@468|Moraxellaceae 1236|Gammaproteobacteria A Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP rtcA GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009975,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360 6.5.1.4 ko:K01974 - - - - ko00000,ko01000 - - - RTC,RTC_insert k59_1250540_1 679197.HMPREF9336_04222 1.87e-80 268.0 COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria 201174|Actinobacteria E Dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_724255_1 1229909.NSED_05420 4.23e-62 211.0 COG0574@1|root,arCOG01111@2157|Archaea,41SYV@651137|Thaumarchaeota 651137|Thaumarchaeota G Pyruvate phosphate dikinase - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_934667_1 1499967.BAYZ01000014_gene6407 2.66e-62 213.0 COG0367@1|root,COG0367@2|Bacteria,2NNKE@2323|unclassified Bacteria 2|Bacteria E PFAM asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_151391_1 190650.CC_0202 4.14e-35 134.0 COG3239@1|root,COG3239@2|Bacteria,1MVY5@1224|Proteobacteria,2U156@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_1343712_1 1122182.KB903839_gene1076 3.14e-24 98.2 COG0748@1|root,COG0748@2|Bacteria,2IFYD@201174|Actinobacteria,4DD92@85008|Micromonosporales 201174|Actinobacteria P F420H(2)-dependent quinone reductase - - - - - - - - - - - - F420H2_quin_red k59_981201_1 1382306.JNIM01000001_gene2994 4.48e-17 83.6 COG0668@1|root,COG0668@2|Bacteria 2|Bacteria M transmembrane transport cmpX - - - - - - - - - - - MS_channel,TM_helix k59_1250559_1 768671.ThimaDRAFT_0808 5.69e-100 304.0 COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1WXN7@135613|Chromatiales 135613|Chromatiales P Chromate transporter - - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_1457758_1 1380394.JADL01000012_gene856 1.37e-47 168.0 28JZQ@1|root,2Z9PN@2|Bacteria,1N2WN@1224|Proteobacteria,2U0QD@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1457758_2 331869.BAL199_03444 5.09e-12 67.0 COG0477@1|root,COG2814@2|Bacteria,1P3S4@1224|Proteobacteria,2TVAQ@28211|Alphaproteobacteria,4BRZV@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - - k59_1250566_1 330214.NIDE3314 2.46e-96 299.0 COG0531@1|root,COG0531@2|Bacteria 2|Bacteria E amino acid - - - - - - - - - - - - AA_permease_2 k59_565058_1 444860.E3SJA0_9CAUD 5.57e-45 156.0 4QBQH@10239|Viruses,4QZ5U@35237|dsDNA viruses no RNA stage,4QU2Y@28883|Caudovirales,4QJJN@10662|Myoviridae 10662|Myoviridae S galactoside 2-alpha-L-fucosyltransferase activity - - - - - - - - - - - - - k59_307547_1 1528106.JRJE01000019_gene2179 1.27e-61 216.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2TS7S@28211|Alphaproteobacteria,2JQ0Q@204441|Rhodospirillales 204441|Rhodospirillales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_878698_2 43989.cce_2488 2.16e-18 90.1 COG1696@1|root,COG1696@2|Bacteria,1FZXB@1117|Cyanobacteria,3KHWG@43988|Cyanothece 1117|Cyanobacteria M MBOAT, membrane-bound O-acyltransferase family - - - ko:K19294 - - - - ko00000 - - - MBOAT k59_465066_1 876044.IMCC3088_946 9.33e-96 282.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,1J50H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_465066_2 283699.D172_1393 4.57e-11 59.3 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,1S973@1236|Gammaproteobacteria,2Q2UI@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_1187510_1 330214.NIDE2719 5.33e-35 131.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cusB - - ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_724281_1 1317118.ATO8_08021 4.15e-08 61.2 COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2TRIB@28211|Alphaproteobacteria,4KKNG@93682|Roseivivax 28211|Alphaproteobacteria Q Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 k59_724281_2 272624.lpg1040 2.44e-36 129.0 COG2020@1|root,COG2020@2|Bacteria,1MUBZ@1224|Proteobacteria,1RREG@1236|Gammaproteobacteria,1JCMM@118969|Legionellales 118969|Legionellales O Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - - - - - - - - - - ICMT,PEMT k59_252204_1 1492922.GY26_15075 2.27e-42 153.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1J54M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) - - 4.2.3.152,4.2.3.4 ko:K01735,ko:K19969 ko00400,ko00525,ko01100,ko01110,ko01130,ko01230,map00400,map00525,map01100,map01110,map01130,map01230 M00022,M00814,M00815 R03083,R10937 RC00847,RC03308 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_1250600_1 177439.DP1202 6.29e-95 294.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2MHX9@213118|Desulfobacterales 28221|Deltaproteobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_981253_1 1129794.C427_5381 7.27e-68 219.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,464CH@72275|Alteromonadaceae 1236|Gammaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063,iJN746.PP_4889 Adenylsucc_synt k59_773381_1 1042377.AFPJ01000009_gene192 1.54e-54 185.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,1RZ4V@1236|Gammaproteobacteria,465TN@72275|Alteromonadaceae 1236|Gammaproteobacteria M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1 k59_1457833_1 1173264.KI913949_gene2305 1.88e-44 157.0 COG3409@1|root,COG3772@1|root,COG3409@2|Bacteria,COG3772@2|Bacteria,1G6C9@1117|Cyanobacteria 1117|Cyanobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - PG_binding_1,Phage_lysozyme k59_724331_1 187272.Mlg_2465 3.48e-06 54.3 2C4IG@1|root,2Z8A1@2|Bacteria,1QTHZ@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_252250_1 754477.Q7C_2395 1.84e-171 486.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,45ZSW@72273|Thiotrichales 72273|Thiotrichales J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_359576_1 177439.DP1432 3.11e-56 187.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,42MSF@68525|delta/epsilon subdivisions,2WKJ5@28221|Deltaproteobacteria,2MI15@213118|Desulfobacterales 68525|delta/epsilon subdivisions C Belongs to the AlaDH PNT family - - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_1036365_2 1283300.ATXB01000001_gene1286 4.33e-14 70.9 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1XEDQ@135618|Methylococcales 135618|Methylococcales F Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_1092685_1 314231.FP2506_13369 2.02e-63 218.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria 28211|Alphaproteobacteria C FAD linked oxidase domain protein MA20_43170 - - - - - - - - - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_1252285_1 1367847.JCM7686_2527 0.00014 44.3 COG2863@1|root,COG2863@2|Bacteria,1PYBB@1224|Proteobacteria,2VAHB@28211|Alphaproteobacteria,2PXRK@265|Paracoccus 28211|Alphaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrom_C k59_1252285_2 1089550.ATTH01000001_gene1052 3.03e-08 58.2 COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,1FJR9@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp k59_1036370_1 96561.Dole_0417 4.8e-67 218.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WMKZ@28221|Deltaproteobacteria,2MJ0R@213118|Desulfobacterales 28221|Deltaproteobacteria P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_1189045_1 153948.NAL212_1200 1.79e-52 186.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2VP0G@28216|Betaproteobacteria 28216|Betaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_412141_1 2340.JV46_13030 1.59e-31 119.0 COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,1S7ID@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_412141_2 1027273.GZ77_13365 2.26e-14 72.4 COG4638@1|root,COG4638@2|Bacteria,1MV2G@1224|Proteobacteria,1RQ8W@1236|Gammaproteobacteria,1XJ5E@135619|Oceanospirillales 135619|Oceanospirillales P Rieske 2Fe-2S - - 1.14.13.82 ko:K03862 ko00627,ko01120,map00627,map01120 - R05274 RC00392,RC01533 ko00000,ko00001,ko01000 - - - Rieske k59_253439_1 1268635.Loa_02179 1.94e-38 142.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria,1JCKR@118969|Legionellales 118969|Legionellales E Amino acid permease - - - - - - - - - - - - AA_permease_2 k59_936214_2 411490.ANACAC_02901 1.18e-09 60.5 COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,247QZ@186801|Clostridia 186801|Clostridia E abc transporter atp-binding protein - - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran k59_1608030_1 159450.NH14_09425 4.06e-56 184.0 COG0169@1|root,COG0169@2|Bacteria,1QWHD@1224|Proteobacteria,2WH08@28216|Betaproteobacteria,1KIG2@119060|Burkholderiaceae 28216|Betaproteobacteria E Methylene-tetrahydromethanopterin dehydrogenase, N-terminal - - - ko:K10714 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 - R08059 RC00202 ko00000,ko00001,ko01000 - - - Mpt_N k59_153128_1 1255043.TVNIR_3135 1.04e-104 332.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1WVW8@135613|Chromatiales 135613|Chromatiales EF Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_253444_1 1219035.NT2_07_01140 5.23e-108 329.0 COG4638@1|root,COG4638@2|Bacteria,1MXZN@1224|Proteobacteria,2U2X0@28211|Alphaproteobacteria,2KCF5@204457|Sphingomonadales 204457|Sphingomonadales P Ring hydroxylating alpha subunit (catalytic domain) - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_982857_2 402777.KB235903_gene660 8.13e-54 185.0 COG2192@1|root,COG2192@2|Bacteria,1G1FV@1117|Cyanobacteria,1H9E9@1150|Oscillatoriales 1117|Cyanobacteria O carbamoyl transferase, NodU family - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_1189066_1 1469245.JFBG01000011_gene865 4.4e-90 285.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1WVYF@135613|Chromatiales 135613|Chromatiales C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_774569_1 243233.MCA2281 2.41e-20 89.4 COG0121@1|root,COG0121@2|Bacteria,1PX9X@1224|Proteobacteria,1SBGN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Glutamine amidotransferase egtC - - - - - - - - - - - GATase_4 k59_774570_1 713586.KB900536_gene651 1.19e-79 261.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WW6D@135613|Chromatiales 135613|Chromatiales C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_619225_2 886377.Murru_3007 7.31e-41 137.0 COG2963@1|root,COG2963@2|Bacteria,4NQ94@976|Bacteroidetes,1I549@117743|Flavobacteriia 976|Bacteroidetes L Pfam Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_1459288_2 713605.ADHG01000004_gene1089 3.68e-10 60.5 COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,4HII1@91061|Bacilli,3F6WZ@33958|Lactobacillaceae 91061|Bacilli J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_774581_1 1131814.JAFO01000001_gene845 4.13e-09 54.3 COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2U98K@28211|Alphaproteobacteria,3EZSP@335928|Xanthobacteraceae 28211|Alphaproteobacteria C Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions - - - ko:K05524 - - - - ko00000 - - - DUF3470,Fer4,Fer4_4 k59_197194_1 713586.KB900536_gene2995 4.54e-113 349.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_982882_1 113395.AXAI01000018_gene4877 1.59e-06 51.6 COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2TS0U@28211|Alphaproteobacteria,3JRSC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_197199_1 153948.NAL212_0924 2.13e-43 143.0 COG2827@1|root,COG2827@2|Bacteria,1MZME@1224|Proteobacteria,2VURH@28216|Betaproteobacteria,373GA@32003|Nitrosomonadales 28216|Betaproteobacteria L PFAM Excinuclease ABC, C subunit - - - ko:K07461 - - - - ko00000 - - - GIY-YIG k59_1189094_1 395963.Bind_2534 9.28e-10 64.7 COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,3NB0G@45404|Beijerinckiaceae 28211|Alphaproteobacteria G HpcH/HpaI aldolase/citrate lyase family - - 4.1.3.25,4.1.3.34 ko:K01644,ko:K18292 ko00660,ko01100,ko02020,map00660,map01100,map02020 - R00237,R00362 RC00067,RC00502,RC01118,RC01205 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_197200_1 330214.NIDE2978 6.94e-26 103.0 COG4956@1|root,COG4956@2|Bacteria,3J0G5@40117|Nitrospirae 40117|Nitrospirae S Large family of predicted nucleotide-binding domains - - - - - - - - - - - - TRAM k59_197200_2 1120959.ATXF01000004_gene2983 3.45e-16 81.6 COG1028@1|root,COG1211@1|root,COG1028@2|Bacteria,COG1211@2|Bacteria,2GNHP@201174|Actinobacteria,4FPYH@85023|Microbacteriaceae 201174|Actinobacteria IQ 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase ispD - 1.1.1.405,2.7.7.40,2.7.7.60 ko:K00991,ko:K21681 ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130 M00096 R01525,R02921,R05633 RC00002,RC00089 ko00000,ko00001,ko00002,ko01000 - - - IspD,adh_short k59_51157_1 1485544.JQKP01000017_gene630 5.61e-07 51.2 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,2VR79@28216|Betaproteobacteria,44VTR@713636|Nitrosomonadales 28216|Betaproteobacteria J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_51157_2 95619.PM1_0204675 5.63e-34 118.0 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,1S8R8@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_51157_3 903503.MEPCIT_103 2.49e-15 71.6 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,1S3WS@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_51218_1 887898.HMPREF0551_1638 3e-14 71.6 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VISA@28216|Betaproteobacteria,1K19D@119060|Burkholderiaceae 28216|Betaproteobacteria C glycolate oxidase (Iron-sulfur subunit) glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7,Fer4_8 k59_51218_2 243159.AFE_1664 7.51e-130 382.0 COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,1RN4G@1236|Gammaproteobacteria,2NC9T@225057|Acidithiobacillales 225057|Acidithiobacillales C FAD binding domain glcE - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 k59_51249_1 397287.C807_00152 3.43e-36 128.0 COG5485@1|root,COG5485@2|Bacteria,1V4VN@1239|Firmicutes,24IWY@186801|Clostridia,27RWM@186928|unclassified Lachnospiraceae 186801|Clostridia S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL k59_51279_1 1323663.AROI01000020_gene721 1.39e-33 131.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_51332_1 330214.NIDE1125 5.84e-11 61.6 COG0301@1|root,COG0301@2|Bacteria 2|Bacteria H tRNA thio-modification thiI GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07461 - ko00000,ko00001,ko01000,ko03016 - - iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307 THUMP,ThiI k59_51332_2 330214.NIDE1127 1.11e-68 216.0 COG0492@1|root,COG0492@2|Bacteria,3J0M0@40117|Nitrospirae 40117|Nitrospirae C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_3 k59_51469_1 713587.THITH_06345 2.92e-155 444.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1WXEN@135613|Chromatiales 135613|Chromatiales H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_51469_2 1088869.GMO_18370 1.96e-11 63.5 COG1073@1|root,COG1073@2|Bacteria,1QV2M@1224|Proteobacteria,2TW92@28211|Alphaproteobacteria,2JYWJ@204441|Rhodospirillales 204441|Rhodospirillales S Serine aminopeptidase, S33 - - - ko:K01175 - - - - ko00000,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_51543_1 1049564.TevJSym_ac00410 8.12e-09 55.8 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria,1J5G5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family wbpO - - ko:K02474 ko00520,map00520 - R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_51543_2 1122197.ATWI01000009_gene1817 1.01e-55 184.0 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,464JQ@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0451 Nucleoside-diphosphate-sugar epimerases capI - 5.1.3.25,5.1.3.6 ko:K08679,ko:K17947 ko00520,ko00523,ko01100,ko01130,map00520,map00523,map01100,map01130 - R01385,R10279 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_51655_1 323261.Noc_1154 1.42e-41 144.0 COG2755@1|root,COG2755@2|Bacteria,1RHDZ@1224|Proteobacteria,1S60V@1236|Gammaproteobacteria,1WYHQ@135613|Chromatiales 135613|Chromatiales E lipolytic protein G-D-S-L family - - - - - - - - - - - - Lipase_GDSL_2 k59_51716_1 880073.Calab_1263 3.01e-45 164.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - Paired_CXXCH_1 k59_51823_1 1116472.MGMO_37c00390 5.61e-10 65.1 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1,Methyltransf_11,Methyltransf_23,Methyltransf_25 k59_51867_1 47716.JOFH01000004_gene982 7.96e-15 79.3 COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria 201174|Actinobacteria IQ Peptidase S15 - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_51877_1 648996.Theam_1102 1.05e-54 186.0 COG2204@1|root,COG2204@2|Bacteria,2G3T9@200783|Aquificae 200783|Aquificae T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481,ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_57054_1 56780.SYN_00437 1.07e-102 310.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2WJAZ@28221|Deltaproteobacteria,2MQ7W@213462|Syntrophobacterales 28221|Deltaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_1258434_1 1384056.N787_09440 4.06e-08 53.9 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1X50B@135614|Xanthomonadales 135614|Xanthomonadales D Peptidase M23 - - - - - - - - - - - - Peptidase_M23 k59_1258434_2 686340.Metal_2685 8.21e-68 220.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1XEI9@135618|Methylococcales 135618|Methylococcales M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_1309551_1 1131553.JIBI01000071_gene2158 2.75e-12 66.2 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2VIH1@28216|Betaproteobacteria,3720Q@32003|Nitrosomonadales 28216|Betaproteobacteria C TrkA-N domain protein trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_1309551_2 998674.ATTE01000001_gene506 1.94e-35 134.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,45ZZX@72273|Thiotrichales 72273|Thiotrichales T response regulator receiver - - - - - - - - - - - - DUF229,HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat k59_1206271_1 330214.NIDE1005 1.34e-86 264.0 COG0473@1|root,COG0473@2|Bacteria,3J0JQ@40117|Nitrospirae 40117|Nitrospirae C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_1048675_1 1415780.JPOG01000001_gene2515 1.56e-82 257.0 COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,1S1KW@1236|Gammaproteobacteria,1X742@135614|Xanthomonadales 135614|Xanthomonadales S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_683859_1 323261.Noc_0992 1.54e-44 160.0 COG0412@1|root,COG0412@2|Bacteria,1QW3K@1224|Proteobacteria,1S38F@1236|Gammaproteobacteria,1X0ND@135613|Chromatiales 135613|Chromatiales Q Alpha/beta hydrolase family - - - - - - - - - - - - - k59_526195_2 1121921.KB898708_gene1340 6.49e-33 125.0 COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria,2PNRM@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Tetratricopeptide repeat-like domain yfgM GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0044425,GO:0044459,GO:0044464,GO:0071575,GO:0071944,GO:0098552 - - - - - - - - - - TPR_21 k59_108013_1 314285.KT71_01620 2.18e-75 243.0 COG4805@1|root,COG4805@2|Bacteria,1R4HM@1224|Proteobacteria,1SKZF@1236|Gammaproteobacteria,1J9TG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - - k59_1362136_1 469383.Cwoe_1834 3.04e-27 115.0 COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4CPIV@84995|Rubrobacteria 84995|Rubrobacteria Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_1309568_1 2340.JV46_28740 3.4e-139 423.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1J58G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD k59_1466783_1 1047013.AQSP01000126_gene2726 6.07e-90 281.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2NNR2@2323|unclassified Bacteria 2|Bacteria G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_526199_1 323261.Noc_2577 1.41e-06 47.0 2C0ET@1|root,33A9M@2|Bacteria,1NGE5@1224|Proteobacteria,1SX58@1236|Gammaproteobacteria,1WZBH@135613|Chromatiales 135613|Chromatiales S TIGRFAM TIGR02449 family protein - - - ko:K09892 - - - - ko00000,ko03036 - - - - k59_526199_2 395493.BegalDRAFT_2649 1.34e-20 86.3 COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,1SCBI@1236|Gammaproteobacteria,4635A@72273|Thiotrichales 72273|Thiotrichales D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_265183_1 1278073.MYSTI_01204 1.4e-105 317.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,42PJT@68525|delta/epsilon subdivisions,2WKPW@28221|Deltaproteobacteria,2YXCR@29|Myxococcales 28221|Deltaproteobacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_996010_1 953739.SVEN_3333 2.23e-84 270.0 COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria 201174|Actinobacteria I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1152978_2 339671.Asuc_1458 1.13e-21 88.2 COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,1SDIM@1236|Gammaproteobacteria,1Y8VR@135625|Pasteurellales 135625|Pasteurellales J RNA-binding protein containing KH domain, possibly ribosomal protein VY92_07230 - - ko:K07574 - - - - ko00000,ko03009 - - - CRS1_YhbY k59_1152978_3 396588.Tgr7_0980 7.49e-13 67.4 COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,1WX98@135613|Chromatiales 135613|Chromatiales J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit ftsJ - 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_1414093_1 375286.mma_3197 8.32e-87 268.0 COG2866@1|root,COG2866@2|Bacteria,1N9AY@1224|Proteobacteria,2VID4@28216|Betaproteobacteria,473BR@75682|Oxalobacteraceae 28216|Betaproteobacteria E Protein of unknown function (DUF2817) - - - - - - - - - - - - Peptidase_M14 k59_631740_1 264462.Bd1025 1.07e-11 71.6 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,42MRY@68525|delta/epsilon subdivisions,2MT8J@213481|Bdellovibrionales,2WJ4F@28221|Deltaproteobacteria 213481|Bdellovibrionales N transport system involved in gliding motility, auxiliary - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC_transp_aux k59_788384_1 1160137.KB907310_gene4630 2.8e-09 63.2 COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4FW35@85025|Nocardiaceae 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - AAA_22,BTAD,NB-ARC,Trans_reg_C k59_108032_1 1123373.ATXI01000026_gene1549 5.65e-65 213.0 COG1690@1|root,COG1690@2|Bacteria,2GH7Q@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Belongs to the RtcB family rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_1466802_1 1123399.AQVE01000013_gene242 5.98e-72 236.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,45ZN9@72273|Thiotrichales 1236|Gammaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032,ko:K13896 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - ABC_tran,oligo_HPY k59_1206321_1 926550.CLDAP_10020 9.5e-106 320.0 COG2225@1|root,COG2225@2|Bacteria,2G63R@200795|Chloroflexi 200795|Chloroflexi H Belongs to the malate synthase family aceB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_1048712_1 86416.Clopa_3125 7.99e-52 179.0 COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,36E3A@31979|Clostridiaceae 186801|Clostridia H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k59_265203_1 1348657.M622_01105 5.56e-92 281.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2VJ4F@28216|Betaproteobacteria,2KUDA@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism - - - - - - - - - - - - SHMT k59_631754_1 1156937.MFUM_750016 1.11e-67 225.0 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,46YW3@74201|Verrucomicrobia,37G5X@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia S AAA domain gntK - - ko:K07028 - - - - ko00000 - - - AAA_33 k59_1414108_1 1128421.JAGA01000002_gene850 1.59e-178 517.0 COG3044@1|root,COG3044@2|Bacteria,2NNSZ@2323|unclassified Bacteria 2|Bacteria S Predicted ATPase of the ABC class - - - - - - - - - - - - ABC_ATPase k59_421900_2 1229172.JQFA01000002_gene4765 0.000122 47.8 COG0477@1|root,COG2814@2|Bacteria,1G41I@1117|Cyanobacteria,1HB5R@1150|Oscillatoriales 1117|Cyanobacteria EGP MFS_1 like family - - - ko:K08151 - M00668 - - ko00000,ko00002,ko01504,ko02000 2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75 - - MFS_1,Sugar_tr k59_108039_1 1434929.X946_3690 2.05e-39 144.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VJDW@28216|Betaproteobacteria,1K16N@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM L-carnitine dehydratase bile acid-inducible protein F - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_108039_2 1397666.RS24_01522 8.43e-137 397.0 COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria,4BRHN@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - ko:K18244 - - - - ko00000,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_57112_1 247634.GPB2148_868 2.51e-97 297.0 COG4638@1|root,COG4638@2|Bacteria,1N1S6@1224|Proteobacteria,1S8ZC@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_57112_2 105559.Nwat_1982 2.29e-10 60.8 COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,1RS4U@1236|Gammaproteobacteria 1224|Proteobacteria G Glucoamylase and related glycosyl hydrolases - - - - - - - - - - - - Glyco_hydro_15 k59_631763_1 977880.RALTA_A1536 4.19e-73 243.0 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria 28216|Betaproteobacteria E Spermine/spermidine synthase domain - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_159443_1 204669.Acid345_0263 7.61e-54 198.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia 204432|Acidobacteriia KLTU Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase k59_317711_1 686340.Metal_3216 8.16e-121 367.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1XE7K@135618|Methylococcales 135618|Methylococcales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_735268_1 643867.Ftrac_0874 5.5e-21 97.8 COG3291@1|root,COG5492@1|root,COG3291@2|Bacteria,COG5492@2|Bacteria,4PHTS@976|Bacteroidetes,47Q40@768503|Cytophagia 976|Bacteroidetes DZ regulator of chromosome condensation, RCC1 - - - - - - - - - - - - CHU_C k59_839785_1 1532557.JL37_06810 4.26e-06 50.8 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2VHJR@28216|Betaproteobacteria,3T1CS@506|Alcaligenaceae 28216|Betaproteobacteria I Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_839785_2 859657.RPSI07_1949 3.26e-18 82.4 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria,1K13G@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the skp family ompH - - ko:K06142 - - - - ko00000 - - - OmpH k59_683922_1 290512.Paes_1070 8.32e-72 226.0 COG3588@1|root,COG3588@2|Bacteria,1FEFW@1090|Chlorobi 1090|Chlorobi G PFAM fructose-bisphosphate aldolase class-I - - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic k59_683922_2 688270.Celal_2574 4.53e-11 67.4 COG2761@1|root,COG2761@2|Bacteria,4NJ3N@976|Bacteroidetes,1HXDF@117743|Flavobacteriia,1F8R6@104264|Cellulophaga 976|Bacteroidetes Q COGs COG2761 dithiol-disulfide isomerase involved in polyketide biosynthesis - - - - - - - - - - - - DSBA k59_1414129_1 1463854.JOHT01000009_gene1881 1.23e-25 105.0 COG0709@1|root,COG0709@2|Bacteria,2GNP4@201174|Actinobacteria 201174|Actinobacteria E Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C k59_1153025_1 985665.HPL003_25715 4.22e-86 281.0 COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,4HAG1@91061|Bacilli,26QCH@186822|Paenibacillaceae 91061|Bacilli J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_631783_1 396588.Tgr7_1911 2.53e-80 248.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1WWWT@135613|Chromatiales 135613|Chromatiales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_996052_1 1177181.T9A_01017 5.18e-67 206.0 COG3011@1|root,COG3011@2|Bacteria,1N6ZR@1224|Proteobacteria,1SEXR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function, DUF393 - - - - - - - - - - - - DUF393 k59_1206362_1 1379698.RBG1_1C00001G1052 5.53e-07 50.8 COG0852@1|root,COG0852@2|Bacteria,2NPN6@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iAF987.Gmet_3353 Complex1_30kDa k59_1206362_2 977880.RALTA_A1035 2.57e-104 302.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,2VIWK@28216|Betaproteobacteria,1K10B@119060|Burkholderiaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_421925_1 1267534.KB906754_gene3820 1.34e-36 141.0 COG2234@1|root,COG2234@2|Bacteria,3Y3S9@57723|Acidobacteria,2JIF0@204432|Acidobacteriia 204432|Acidobacteriia S PA domain - - - - - - - - - - - - PA,Peptidase_M28 k59_1466840_1 1208321.D104_06945 8.55e-84 253.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1XH9B@135619|Oceanospirillales 135619|Oceanospirillales J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_1258535_1 1100720.ALKN01000043_gene2731 3.75e-18 89.7 COG0789@1|root,COG0789@2|Bacteria,1RCE4@1224|Proteobacteria,2VR0N@28216|Betaproteobacteria 28216|Betaproteobacteria K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 k59_1309634_1 713586.KB900536_gene1022 8.14e-78 244.0 COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,1RS7Z@1236|Gammaproteobacteria,1WX2A@135613|Chromatiales 135613|Chromatiales C PFAM Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_943909_1 384765.SIAM614_27707 1.25e-36 133.0 COG1442@1|root,COG1442@2|Bacteria,1QH4S@1224|Proteobacteria,2U9KQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria M glycosyl transferase family 8 - - - - - - - - - - - - - k59_1466850_2 1089551.KE386572_gene1826 1.57e-32 127.0 COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2TTMN@28211|Alphaproteobacteria,4BRUU@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_14,TPR_16,TPR_19,TPR_2,TPR_8 k59_1206381_1 2002.JOEQ01000004_gene2970 8.26e-53 188.0 COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4EGYX@85012|Streptosporangiales 201174|Actinobacteria E Bacterial NAD-glutamate dehydrogenase gdh - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_631814_2 1211115.ALIQ01000196_gene65 6.33e-29 115.0 COG0584@1|root,COG0584@2|Bacteria,1MW6Z@1224|Proteobacteria 1224|Proteobacteria C glycerophosphoryl diester phosphodiesterase - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_1153050_1 400668.Mmwyl1_1178 1.73e-76 243.0 COG1396@1|root,COG1396@2|Bacteria,1R3Z8@1224|Proteobacteria,1RRMV@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional - - - - - - - - - - - - DUF3612,HTH_19,HTH_3,Peptidase_M78 k59_421943_1 357244.OTBS_0057 2.84e-05 50.8 COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,2U0MD@28211|Alphaproteobacteria,47GED@766|Rickettsiales 766|Rickettsiales S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - - k59_1310340_3 220341.16506051 1.38e-44 167.0 COG1783@1|root,COG1783@2|Bacteria,1MWGP@1224|Proteobacteria,1S8D6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Terminase-like family - - - - - - - - - - - - Terminase_6,Terminase_6C k59_1207271_1 298654.FraEuI1c_0551 2.89e-05 49.7 COG1595@1|root,COG1595@2|Bacteria,2GP2X@201174|Actinobacteria,4EWE2@85013|Frankiales 201174|Actinobacteria K Sigma-70, region 4 - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 k59_2535_1 477184.KYC_17938 4.82e-66 211.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,2VHWH@28216|Betaproteobacteria,3T1HY@506|Alcaligenaceae 28216|Betaproteobacteria J Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system ttcA - - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_1310342_1 436308.Nmar_0008 3.36e-71 226.0 COG1252@1|root,arCOG01067@2157|Archaea 2157|Archaea C COG1252 NADH dehydrogenase, FAD-containing subunit ndh2 - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1310342_2 1229909.NSED_09680 5.68e-23 93.2 arCOG01806@1|root,arCOG01806@2157|Archaea,41T2B@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1414915_1 111780.Sta7437_0488 2.41e-09 65.9 COG0517@1|root,COG2203@1|root,COG4191@1|root,COG5002@1|root,COG0517@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1FZYQ@1117|Cyanobacteria,3VI2D@52604|Pleurocapsales 1117|Cyanobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - CBS,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_892866_1 261292.Nit79A3_0519 5.95e-35 137.0 COG1033@1|root,COG1033@2|Bacteria,1QVYU@1224|Proteobacteria,2WGVE@28216|Betaproteobacteria 28216|Betaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_526892_1 1120965.AUBV01000005_gene1620 1.02e-104 321.0 COG1053@1|root,COG1053@2|Bacteria,4NFDU@976|Bacteroidetes,47JE5@768503|Cytophagia 976|Bacteroidetes C TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_684777_1 1049564.TevJSym_ai00210 6.42e-98 302.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1J4VX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_1310357_1 436308.Nmar_0846 6.91e-84 258.0 COG0026@1|root,arCOG01597@2157|Archaea,41SD9@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_996761_1 177439.DP0498 5.32e-13 67.0 COG0011@1|root,COG0011@2|Bacteria,1PTFE@1224|Proteobacteria,43EYI@68525|delta/epsilon subdivisions,2WTF2@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Thiamine-binding protein - - - - - - - - - - - - Thiamine_BP k59_1101756_1 236097.ADG881_1039 1.03e-135 412.0 COG0834@1|root,COG4623@1|root,COG0834@2|Bacteria,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1XI7H@135619|Oceanospirillales 135619|Oceanospirillales M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella - - - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_159911_1 398720.MED217_00800 1.24e-29 120.0 COG1253@1|root,COG1253@2|Bacteria,4NDZ7@976|Bacteroidetes,1HXF3@117743|Flavobacteriia,2XIMA@283735|Leeuwenhoekiella 976|Bacteroidetes S Transporter associated domain gldE - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1467587_1 1123399.AQVE01000035_gene3168 1.04e-87 284.0 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07673 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF_2,HAMP,HATPase_c,HisKA_3 k59_1467587_2 765910.MARPU_10850 2.67e-33 119.0 COG0316@1|root,COG0316@2|Bacteria,1RKPC@1224|Proteobacteria,1SB76@1236|Gammaproteobacteria,1WYKT@135613|Chromatiales 135613|Chromatiales S Belongs to the HesB IscA family - - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_684782_1 1047013.AQSP01000120_gene936 4.35e-104 327.0 COG4354@1|root,COG4354@2|Bacteria,2NQ9B@2323|unclassified Bacteria 2|Bacteria G beta-glucosidase 2, glycosyl-hydrolase family 116 N-term - - - - - - - - - - - - DUF608,Glyco_hydr_116N k59_1476194_2 396595.TK90_0661 5.46e-23 95.1 COG3222@1|root,COG3222@2|Bacteria,1RB1V@1224|Proteobacteria,1S971@1236|Gammaproteobacteria,1WYN8@135613|Chromatiales 135613|Chromatiales S Uncharacterized protein conserved in bacteria (DUF2064) - - - ko:K09931 - - - - ko00000 - - - DUF2064 k59_1056399_1 1196322.A370_01080 3.73e-30 111.0 COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,24JVN@186801|Clostridia,36K0M@31979|Clostridiaceae 186801|Clostridia H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox k59_1056399_2 330214.NIDE2918 4.8e-65 213.0 COG0154@1|root,COG0154@2|Bacteria,3J0AA@40117|Nitrospirae 40117|Nitrospirae J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_429416_1 562970.Btus_0709 2.89e-47 165.0 COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,4H9MX@91061|Bacilli,277WD@186823|Alicyclobacillaceae 91061|Bacilli E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_641426_2 29760.VIT_02s0025g01290.t01 1.97e-11 64.7 COG3571@1|root,KOG3253@2759|Eukaryota,37PD7@33090|Viridiplantae,3GBZQ@35493|Streptophyta 35493|Streptophyta S KAT8 regulatory NSL complex subunit - - - ko:K07020 - - - - ko00000 - - - Abhydrolase_1,Abhydrolase_5,Abhydrolase_6,DLH k59_1522469_1 339670.Bamb_0683 2.52e-15 75.5 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2VJ4F@28216|Betaproteobacteria,1K0G0@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_1522469_2 365046.Rta_14950 1.84e-89 270.0 28I6Z@1|root,2Z89U@2|Bacteria,1R8YM@1224|Proteobacteria 1224|Proteobacteria S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_1522469_3 365046.Rta_14960 6.68e-167 487.0 28HC9@1|root,2Z7P5@2|Bacteria,1R4BH@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1476201_1 1499967.BAYZ01000057_gene4687 3.98e-92 280.0 COG1702@1|root,COG1702@2|Bacteria,2NNZF@2323|unclassified Bacteria 2|Bacteria T PhoH-like protein phoH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K06217 - - - - ko00000 - - - PhoH k59_429424_1 398579.Spea_0972 8.75e-08 55.1 COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,2Q9JH@267890|Shewanellaceae 1236|Gammaproteobacteria MU PFAM Peptidoglycan-binding domain 1 protein gspA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1,T2SSB k59_482480_2 1492922.GY26_01760 2.79e-71 224.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,1J5PS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0000287,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019899,GO:0022613,GO:0032296,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_742522_1 95619.PM1_0226535 7.14e-56 197.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1056415_1 525897.Dbac_1485 1.23e-59 199.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_641442_1 59921.EU92_0452 2.1e-40 145.0 COG0463@1|root,COG0463@2|Bacteria,1G03Y@1117|Cyanobacteria,1MM4C@1212|Prochloraceae 1117|Cyanobacteria M Alternative locus ID - - 2.4.1.83 ko:K00721,ko:K20534 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 k59_482484_1 686340.Metal_2202 1.28e-154 454.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1XEBM@135618|Methylococcales 135618|Methylococcales O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_1056418_1 1123400.KB904753_gene1059 4.22e-87 267.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,46064@72273|Thiotrichales 72273|Thiotrichales E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_1631083_1 545695.TREAZ_0552 8.75e-07 57.0 COG4775@1|root,COG4775@2|Bacteria,2J5BP@203691|Spirochaetes 203691|Spirochaetes M Outer membrane protein assembly complex, YaeT protein yaeT - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_899743_1 472759.Nhal_1219 6.57e-138 399.0 COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,1RNYV@1236|Gammaproteobacteria,1WXG7@135613|Chromatiales 135613|Chromatiales Q Fumarylacetoacetate (FAA) hydrolase family - - 3.7.1.2 ko:K16171 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_798480_1 1239962.C943_02799 4.34e-58 204.0 COG2114@1|root,COG3292@1|root,COG2114@2|Bacteria,COG3292@2|Bacteria,4NEVN@976|Bacteroidetes,47MR3@768503|Cytophagia 976|Bacteroidetes T Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - 7TMR-DISM_7TM,Guanylate_cyc,Reg_prop,Response_reg,TPR_12,Y_Y_Y k59_847290_1 1386969.AWTB01000007_gene2603 6.94e-59 196.0 28KAT@1|root,2Z9XX@2|Bacteria,2GNVW@201174|Actinobacteria,4GAEY@85026|Gordoniaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1522486_1 314264.ROS217_20012 2.25e-28 119.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria,46NWH@74030|Roseovarius 28211|Alphaproteobacteria S transport system, fused permease components - - - - - - - - - - - - DctM k59_1522486_2 314264.ROS217_20032 3.3e-11 61.2 COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2VGRS@28211|Alphaproteobacteria 28211|Alphaproteobacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA - - - - - - - - - - - - Biotin_lipoyl k59_951194_2 272562.CA_C2712 1.02e-33 125.0 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,36EDS@31979|Clostridiaceae 186801|Clostridia I Belongs to the enoyl-CoA hydratase isomerase family crt - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_115283_1 1385520.N802_16560 3.65e-13 71.6 COG0489@1|root,COG3944@1|root,COG0489@2|Bacteria,COG3944@2|Bacteria,2GJ1Y@201174|Actinobacteria,4FFZV@85021|Intrasporangiaceae 201174|Actinobacteria DM biosynthesis protein - - - - - - - - - - - - ParA,Wzz k59_798496_1 1385517.N800_13180 7.31e-68 231.0 COG2373@1|root,COG4932@1|root,COG2373@2|Bacteria,COG4932@2|Bacteria,1QZFW@1224|Proteobacteria 1224|Proteobacteria M domain protein - - - - - - - - - - - - DUF11,SdrD_B k59_1476254_1 2074.JNYD01000003_gene3796 4.85e-09 62.0 COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria,4E3BK@85010|Pseudonocardiales 201174|Actinobacteria T Transcriptional regulatory protein, C terminal - - - ko:K07776 ko02020,map02020 M00443 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_848049_1 1449048.JQKU01000001_gene2274 4.22e-12 66.6 COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,232KS@1762|Mycobacteriaceae 201174|Actinobacteria Q cytochrome p450 - - 1.14.15.14 ko:K20497 - - - - ko00000,ko00199,ko01000 - - - p450 k59_848049_2 247634.GPB2148_3530 3.37e-29 112.0 COG2141@1|root,COG2141@2|Bacteria,1R76K@1224|Proteobacteria,1RTQB@1236|Gammaproteobacteria,1J5BE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_1057251_1 123899.JPQP01000002_gene974 1.99e-82 260.0 COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2VKKY@28216|Betaproteobacteria,3T5RY@506|Alcaligenaceae 28216|Betaproteobacteria EG Belongs to the IlvD Edd family ilvD4 - 4.2.1.82,4.2.1.9 ko:K01687,ko:K22186 ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R02429,R04441,R05070 RC00468,RC00543,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_693189_1 76114.ebA1642 7.59e-35 134.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2VHG1@28216|Betaproteobacteria,2KUK1@206389|Rhodocyclales 206389|Rhodocyclales MU COG1538 Outer membrane protein tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_1216220_1 469610.HMPREF0189_02104 4.12e-73 236.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2VHF7@28216|Betaproteobacteria,1KK1I@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,S4_2,tRNA-synt_1b k59_952057_1 765914.ThisiDRAFT_1401 3.61e-135 393.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1WWGS@135613|Chromatiales 135613|Chromatiales E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - - ko:K10764 ko00270,ko00920,ko01100,map00270,map00920,map01100 - R01288 RC00020,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_900536_1 1122134.KB893650_gene1020 6.8e-61 211.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1XHBY@135619|Oceanospirillales 135619|Oceanospirillales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_848053_1 1125863.JAFN01000001_gene1462 1.28e-122 377.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria 28221|Deltaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_430130_1 1229909.NSED_09330 2.69e-66 207.0 COG1010@1|root,arCOG00647@2157|Archaea,41S6W@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.131 ko:K05934 ko00860,ko01100,map00860,map01100 - R05180,R05809 RC00003,RC01293,RC03471 ko00000,ko00001,ko01000 - - - TP_methylase k59_430130_2 436308.Nmar_1751 1.63e-25 102.0 COG0162@1|root,arCOG01886@2157|Archaea,41S8C@651137|Thaumarchaeota 651137|Thaumarchaeota J Tyrosine--tRNA ligase - - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - tRNA-synt_1b k59_799512_1 1469245.JFBG01000063_gene2336 7.2e-85 272.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1WXN6@135613|Chromatiales 135613|Chromatiales J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_534505_1 502025.Hoch_3072 7.42e-46 168.0 COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,42Q1B@68525|delta/epsilon subdivisions,2WKJH@28221|Deltaproteobacteria,2YU85@29|Myxococcales 28221|Deltaproteobacteria G FGGY family of carbohydrate kinases, N-terminal domain - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_1423741_1 649639.Bcell_0569 3.84e-41 150.0 COG2271@1|root,COG2271@2|Bacteria,1V1EM@1239|Firmicutes,4HEM8@91061|Bacilli,1ZDCH@1386|Bacillus 91061|Bacilli G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_900539_1 1242864.D187_004712 7.91e-111 334.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2YU6I@29|Myxococcales 28221|Deltaproteobacteria I Carboxyl transferase domain pccB - 2.1.3.1,2.1.3.15,6.4.1.3 ko:K01966,ko:K17489 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R00353,R01859 RC00040,RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_900539_2 1343740.M271_31150 6.31e-53 186.0 COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria 201174|Actinobacteria I carboxylase accA1 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 6.3.4.14,6.4.1.2,6.4.1.3 ko:K11263 ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv2501c Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_116132_1 290397.Adeh_3433 6.92e-32 127.0 COG0154@1|root,COG0154@2|Bacteria,1MWWQ@1224|Proteobacteria,42NEJ@68525|delta/epsilon subdivisions,2WM86@28221|Deltaproteobacteria,2YYA8@29|Myxococcales 28221|Deltaproteobacteria J Amidase - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_1269261_1 1238182.C882_4194 6.88e-65 208.0 COG0500@1|root,COG2226@2|Bacteria,1RB4F@1224|Proteobacteria,2U613@28211|Alphaproteobacteria,2JSGA@204441|Rhodospirillales 204441|Rhodospirillales Q methyltransferase - - - - - - - - - - - - Methyltransf_25 k59_273595_1 1348635.BBJY01000003_gene3859 5.61e-21 96.3 COG3138@1|root,COG3138@2|Bacteria,1MWHC@1224|Proteobacteria,1RMXG@1236|Gammaproteobacteria,1XU0Z@135623|Vibrionales 135623|Vibrionales E Arginine N-succinyltransferase beta subunit - - 2.3.1.109 ko:K00673 ko00330,ko01100,map00330,map01100 - R00832 RC00004,RC00064 ko00000,ko00001,ko01000 - - - AstA k59_273595_2 765952.PUV_12100 2.3e-91 289.0 COG0160@1|root,COG0160@2|Bacteria,2JFWA@204428|Chlamydiae 204428|Chlamydiae E Aminotransferase class-III argD - - - - - - - - - - - Aminotran_3 k59_116144_1 467661.RKLH11_3778 2.32e-138 402.0 COG0004@1|root,COG0004@2|Bacteria,1MX44@1224|Proteobacteria,2TR55@28211|Alphaproteobacteria,3ZGPX@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria P Ammonium transporter family protein amt - - - - - - - - - - - Ammonium_transp k59_116145_2 1280954.HPO_04635 1.4e-13 70.1 COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,2TTWF@28211|Alphaproteobacteria 28211|Alphaproteobacteria C alcohol dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_1109525_1 1131266.ARWQ01000009_gene916 3.64e-38 135.0 COG2301@1|root,arCOG00760@2157|Archaea,41S6F@651137|Thaumarchaeota 651137|Thaumarchaeota G HpcH/HpaI aldolase/citrate lyase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_1109525_2 436308.Nmar_1622 3.61e-48 162.0 COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_378356_1 765910.MARPU_02750 1.17e-43 152.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1WWQ1@135613|Chromatiales 135613|Chromatiales H Belongs to the ribF family - - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_1477315_1 765910.MARPU_09105 9.39e-68 218.0 COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,1RM9Z@1236|Gammaproteobacteria,1WX87@135613|Chromatiales 135613|Chromatiales S PFAM Paraquat-inducible protein A - - - ko:K03808 - - - - ko00000 - - - PqiA k59_378359_1 1493511.A0A0E3FMD1_9CAUD 2.4e-56 198.0 4QEE7@10239|Viruses,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae 10662|Myoviridae S Pfam:DUF4815 - - - - - - - - - - - - - k59_1477318_2 2055.JNXA01000002_gene2636 0.000326 45.8 COG2030@1|root,COG2030@2|Bacteria,2GN4R@201174|Actinobacteria,4GBME@85026|Gordoniaceae 201174|Actinobacteria I MaoC like domain - - - - - - - - - - - - MaoC_dehydratas k59_221419_1 633147.Olsu_1272 7.83e-22 94.7 COG1660@1|root,COG1660@2|Bacteria,2GMWB@201174|Actinobacteria,4CUJK@84998|Coriobacteriia 84998|Coriobacteriia S Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_221419_2 626523.GCWU000342_01663 2.07e-09 60.5 COG1493@1|root,COG1493@2|Bacteria,1TP5Z@1239|Firmicutes,24999@186801|Clostridia 186801|Clostridia T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_167024_1 243231.GSU1397 5.48e-28 116.0 COG2010@1|root,COG2010@2|Bacteria,1R4K1@1224|Proteobacteria,4331Y@68525|delta/epsilon subdivisions,2WYCA@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Cytochrome c - - - - - - - - - - - - - k59_167024_2 666681.M301_0476 9.37e-10 58.5 2BK6R@1|root,32EKD@2|Bacteria,1RHDK@1224|Proteobacteria,2VT5P@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_5618_1 1299327.I546_2828 1.26e-72 226.0 COG0300@1|root,COG0300@2|Bacteria 2|Bacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_952096_2 1163617.SCD_n02796 1.88e-18 91.7 COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,2VMG1@28216|Betaproteobacteria 28216|Betaproteobacteria H enzyme of heme biosynthesis hemX - 2.1.1.107,4.2.1.75 ko:K02496,ko:K13543 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4,HemX k59_1269303_1 977880.RALTA_A2893 6.5e-51 174.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,1K17C@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,SKI k59_67988_2 1031711.RSPO_c01668 4.79e-35 134.0 COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,2VK64@28216|Betaproteobacteria,1K0U3@119060|Burkholderiaceae 28216|Betaproteobacteria G Belongs to the HpcH HpaI aldolase family hpaI - 4.1.2.52 ko:K02510 ko00350,ko01120,map00350,map01120 - R01645,R01647 RC00307,RC00572,RC00574,RC03057 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_1578903_1 1380391.JIAS01000011_gene4747 1.41e-46 171.0 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,2JQIX@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the GcvT family - - 1.5.3.1 ko:K00302 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2 k59_1370492_1 330214.NIDE1213 2.53e-26 106.0 COG1398@1|root,COG1398@2|Bacteria 2|Bacteria I oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water desC - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_1370492_2 522306.CAP2UW1_3892 1.99e-32 123.0 COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,2VJW8@28216|Betaproteobacteria 28216|Betaproteobacteria T Adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - FHA,Guanylate_cyc k59_1004447_1 110319.CF8_2230 1.25e-11 65.5 COG1020@1|root,COG1020@2|Bacteria,2GKGU@201174|Actinobacteria,4DQ4Z@85009|Propionibacteriales 201174|Actinobacteria Q Belongs to the long-chain O-acyltransferase family - - 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - DUF1298,WES_acyltransf k59_378373_1 686340.Metal_1905 6.64e-33 132.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1XEAS@135618|Methylococcales 135618|Methylococcales M Soluble lytic murein transglycosylase L domain - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_693244_1 754477.Q7C_2227 3.44e-86 267.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,45ZY3@72273|Thiotrichales 72273|Thiotrichales U PFAM Bacterial type II secretion system protein F domain pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_1057306_1 279714.FuraDRAFT_0565 1.92e-44 147.0 COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2VPN0@28216|Betaproteobacteria 28216|Betaproteobacteria S FeS assembly SUF system protein sufT - - - - - - - - - - - FeS_assembly_P k59_1057306_2 1286106.MPL1_05002 1.57e-25 99.4 COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,461GC@72273|Thiotrichales 72273|Thiotrichales C A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters - - - ko:K04488 - - - - ko00000 - - - NifU_N k59_642645_1 43151.ADAC002215-PA 1.38e-142 433.0 COG1877@1|root,KOG1050@2759|Eukaryota,38EGS@33154|Opisthokonta,3BMA5@33208|Metazoa,3CWD5@33213|Bilateria,41VGH@6656|Arthropoda,3SJ1W@50557|Insecta,451ME@7147|Diptera,45EDW@7148|Nematocera 33208|Metazoa G Glycosyltransferase family 20 Tps1 GO:0003674,GO:0003824,GO:0004805,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044464,GO:0046351,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:1901576 2.4.1.15,3.1.3.12 ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,Trehalose_PPase k59_483691_1 868131.MSWAN_1354 3.67e-20 97.1 COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,23NU5@183925|Methanobacteria 183925|Methanobacteria E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_586923_1 357804.Ping_2394 8.83e-10 61.6 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,1RSAX@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Large exoproteins involved in heme utilization or adhesion cupB5 - - - - - - - - - - - ESPR,Glug,Haemagg_act k59_693254_1 521098.Aaci_2345 4.64e-45 166.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,4H9S7@91061|Bacilli,27842@186823|Alicyclobacillaceae 91061|Bacilli L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A k59_1374813_1 1415754.JQMK01000002_gene2697 2.9e-42 159.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,466FE@72275|Alteromonadaceae 1236|Gammaproteobacteria NU Neisseria PilC beta-propeller domain pilY - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,PA14 k59_805602_1 1123288.SOV_2c07740 2.37e-08 55.5 COG4961@1|root,COG4961@2|Bacteria,1VFNR@1239|Firmicutes,4H5JS@909932|Negativicutes 909932|Negativicutes U TadE-like protein - - - - - - - - - - - - TadE k59_805602_2 550540.Fbal_2352 8.75e-05 47.8 COG1989@1|root,COG1989@2|Bacteria,1R34Z@1224|Proteobacteria,1SBEI@1236|Gammaproteobacteria 1236|Gammaproteobacteria NOU PFAM peptidase A24A, prepilin type IV - - 3.4.23.43 ko:K02278 - - - - ko00000,ko01000,ko02035,ko02044 - - - Peptidase_A24 k59_1483311_2 436308.Nmar_1779 7.22e-35 123.0 COG1931@1|root,arCOG01043@2157|Archaea,41SRJ@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the UPF0201 family - - - ko:K09736 - - - - ko00000 - - - RNA_binding k59_1275431_1 1207063.P24_02221 4.07e-144 416.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,2JPG4@204441|Rhodospirillales 204441|Rhodospirillales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_805608_1 159087.Daro_3896 3.6e-23 105.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJBX@28216|Betaproteobacteria,2KU9U@206389|Rhodocyclales 206389|Rhodocyclales NT Methyl-accepting chemotaxis protein pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_1583547_1 391625.PPSIR1_15195 2.52e-77 246.0 COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,42PFG@68525|delta/epsilon subdivisions,2WKPM@28221|Deltaproteobacteria,2YTUX@29|Myxococcales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1583547_2 326424.FRAAL3693 3.24e-07 53.9 COG2045@1|root,COG2045@2|Bacteria,2II0K@201174|Actinobacteria,4EVYF@85013|Frankiales 201174|Actinobacteria H Belongs to the ComB family - - 3.1.3.71 ko:K05979 ko00680,ko01120,map00680,map01120 M00358 R05789 RC00428 ko00000,ko00001,ko00002,ko01000 - - - 2-ph_phosp k59_122121_1 1122604.JONR01000046_gene2087 2.44e-07 58.2 28TC4@1|root,2ZFKJ@2|Bacteria,1P81C@1224|Proteobacteria,1SUYI@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_74840_1 313590.MED134_05554 0.00029 50.4 COG1064@1|root,COG1064@2|Bacteria,4NFGP@976|Bacteroidetes,1HXI9@117743|Flavobacteriia,37EXZ@326319|Dokdonia 976|Bacteroidetes S Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K13953,ko:K13979 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_74840_2 469383.Cwoe_4214 3.1e-76 241.0 COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria 201174|Actinobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit - - 6.2.1.18 ko:K15232 ko00720,ko01100,ko01120,ko01200,map00720,map01100,map01120,map01200 M00173 R01322 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2 k59_1584330_1 375286.mma_2206 2.43e-27 116.0 COG5323@1|root,COG5323@2|Bacteria 2|Bacteria M Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6 k59_1584330_2 1454004.AW11_03825 1.37e-05 48.9 2E5FX@1|root,3307M@2|Bacteria,1N8E5@1224|Proteobacteria,2VWUI@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1164836_1 436308.Nmar_1647 9.06e-88 274.0 arCOG08812@1|root,arCOG08812@2157|Archaea,41T0K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_435921_1 309801.trd_A0275 1.64e-23 106.0 COG1351@1|root,COG1351@2|Bacteria,2G9ZK@200795|Chloroflexi,27XV1@189775|Thermomicrobia 189775|Thermomicrobia F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - - - - - - - - - - Thy1 k59_279207_2 706587.Desti_2217 1.06e-65 207.0 COG3247@1|root,COG3247@2|Bacteria,1RFIH@1224|Proteobacteria,42XZY@68525|delta/epsilon subdivisions,2WSXS@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Short repeat of unknown function (DUF308) - - - - - - - - - - - - DUF308 k59_905927_1 1287116.X734_32900 3.32e-42 149.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2TW1M@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_1062838_2 1123322.KB904655_gene596 3.19e-21 88.6 COG2020@1|root,COG2020@2|Bacteria,2IN0C@201174|Actinobacteria 201174|Actinobacteria O Phospholipid methyltransferase - - - - - - - - - - - - PEMT k59_1221969_1 331869.BAL199_04939 3.91e-06 53.9 COG1589@1|root,COG1589@2|Bacteria,1MY1Q@1224|Proteobacteria,2TQPU@28211|Alphaproteobacteria,4BQNH@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria D Essential cell division protein ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_171899_2 593750.Metfor_2559 7.38e-21 92.0 COG2340@1|root,arCOG03962@2157|Archaea,2XT4K@28890|Euryarchaeota 28890|Euryarchaeota S protein with SCP PR1 domains - - - - - - - - - - - - CAP k59_698554_1 648996.Theam_1121 7.53e-57 192.0 COG1740@1|root,COG1740@2|Bacteria,2G3P1@200783|Aquificae 200783|Aquificae C TIGRFAM hydrogenase (NiFe) small subunit (hydA) - - 1.12.5.1,1.12.99.6 ko:K05927,ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_331682_1 517433.PanABDRAFT_1437 2.22e-82 255.0 COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RM84@1236|Gammaproteobacteria,3VY5Y@53335|Pantoea 1236|Gammaproteobacteria C lysine 2,3-aminomutase epmB GO:0003674,GO:0003824,GO:0005488,GO:0016853,GO:0016866,GO:0016869,GO:0048037,GO:0051536,GO:0051539,GO:0051540 5.4.3.2 ko:K01843,ko:K19810 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000,ko03012 - - iECH74115_1262.ECH74115_5662,iECIAI39_1322.ECIAI39_4611,iS_1188.S4569 Fer4_12,Fer4_14,Radical_SAM k59_649561_1 1229780.BN381_210089 4e-126 379.0 COG0215@1|root,COG0215@2|Bacteria,2GJF2@201174|Actinobacteria,3UWAM@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J tRNA synthetases class I (C) catalytic domain cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_171911_1 330214.NIDE4127 1.85e-78 253.0 COG1185@1|root,COG1185@2|Bacteria,3J0DX@40117|Nitrospirae 40117|Nitrospirae J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_806676_1 1410612.JNKO01000005_gene1106 3.11e-08 57.8 COG0575@1|root,COG0575@2|Bacteria,1V6V6@1239|Firmicutes,24XU6@186801|Clostridia,2PS61@265975|Oribacterium 186801|Clostridia I CDP-archaeol synthase - - - - - - - - - - - - CarS-like k59_490726_2 1337936.IJ00_06620 2.17e-22 98.2 COG0726@1|root,COG0726@2|Bacteria,1G0GG@1117|Cyanobacteria,1HRNI@1161|Nostocales 1117|Cyanobacteria G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_1009801_1 1122603.ATVI01000012_gene1129 3.6e-53 171.0 COG3791@1|root,COG3791@2|Bacteria,1N3P3@1224|Proteobacteria,1S57G@1236|Gammaproteobacteria,1X8YJ@135614|Xanthomonadales 135614|Xanthomonadales S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_698566_1 1357279.N018_02035 1.8e-09 59.3 COG0500@1|root,COG2226@2|Bacteria,1NJBJ@1224|Proteobacteria,1SHEC@1236|Gammaproteobacteria,1Z4TZ@136849|Pseudomonas syringae group 1236|Gammaproteobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 k59_539583_1 485913.Krac_3951 1.84e-108 330.0 COG3666@1|root,COG3666@2|Bacteria,2G998@200795|Chloroflexi 200795|Chloroflexi L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_385402_1 867903.ThesuDRAFT_01803 1.59e-08 60.8 COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1UIY4@1239|Firmicutes,25EZX@186801|Clostridia 186801|Clostridia T TIGRFAM diguanylate cyclase (GGDEF) domain - - - - - - - - - - - - GAF_2,GGDEF k59_806690_1 937777.Deipe_0815 3.16e-07 54.3 COG0406@1|root,COG0406@2|Bacteria 2|Bacteria G alpha-ribazole phosphatase activity - - 3.1.3.3,3.1.3.73,5.4.2.12 ko:K02226,ko:K15634,ko:K22305 ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00122 R00582,R01518,R04594,R11173 RC00017,RC00536 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_539589_1 870187.Thini_3705 5.13e-14 76.3 COG4467@1|root,COG4467@2|Bacteria,1QW8C@1224|Proteobacteria,1S2JX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,zf-IS66 k59_806696_1 525904.Tter_1089 5.91e-77 253.0 COG1472@1|root,COG1472@2|Bacteria,2NNZB@2323|unclassified Bacteria 2|Bacteria G Glycoside hydrolase family 3 domain protein bxlA - 3.2.1.21 ko:K05349,ko:K17641 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_592142_1 118166.JH976537_gene324 1.32e-22 98.6 COG3187@1|root,COG3187@2|Bacteria,1GA7U@1117|Cyanobacteria 1117|Cyanobacteria O META domain - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - META k59_592142_2 1149133.ppKF707_5410 2.92e-38 134.0 COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,1SAQE@1236|Gammaproteobacteria,1YJAG@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Aminoacyl-tRNA editing domain - - - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_592142_3 1239962.C943_03915 2.59e-73 229.0 COG2518@1|root,COG2518@2|Bacteria,4NMTP@976|Bacteroidetes,47MH9@768503|Cytophagia 976|Bacteroidetes J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_490755_1 485915.Dret_0077 1.41e-82 263.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M8CJ@213115|Desulfovibrionales 28221|Deltaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_226547_1 421052.F945_02547 5.47e-16 75.1 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,1RN6F@1236|Gammaproteobacteria,3NIQV@468|Moraxellaceae 1236|Gammaproteobacteria C Electron transfer flavoprotein etfB - - ko:K03521 - - - - ko00000 - - - ETF k59_226547_2 1232410.KI421412_gene177 4.93e-66 208.0 COG1028@1|root,COG1028@2|Bacteria,1MUSQ@1224|Proteobacteria,42YTV@68525|delta/epsilon subdivisions,2WTY1@28221|Deltaproteobacteria,43TGH@69541|Desulfuromonadales 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - ko:K13775 ko00281,map00281 - R08087,R08096,R10125,R10126 RC00080,RC00087 ko00000,ko00001 - - - adh_short k59_123151_1 246200.SPO0557 7.43e-47 171.0 COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,2TSIN@28211|Alphaproteobacteria,4NBRC@97050|Ruegeria 28211|Alphaproteobacteria M Mechanosensitive ion channel - - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel k59_806712_1 1229909.NSED_09345 3.37e-103 303.0 COG0592@1|root,arCOG00488@2157|Archaea,41S6E@651137|Thaumarchaeota 651137|Thaumarchaeota L Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication pcn - - ko:K04802 ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166 M00295 - - ko00000,ko00001,ko00002,ko03032,ko03400 - - - PCNA_C,PCNA_N k59_1114819_1 395493.BegalDRAFT_2698 2.19e-13 75.5 COG3266@1|root,COG3267@1|root,COG3266@2|Bacteria,COG3267@2|Bacteria,1QTDW@1224|Proteobacteria,1RXD3@1236|Gammaproteobacteria,461GI@72273|Thiotrichales 72273|Thiotrichales U domain, Protein - - - ko:K03112 - - - - ko00000 - - - AAA_22,SPOR k59_1584403_1 1049564.TevJSym_ay00040 4.21e-21 95.5 COG0189@1|root,COG0189@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria 1236|Gammaproteobacteria HJ GNAT family acetyltransferase cphA - - - - - - - - - - - Acetyltransf_1,RimK k59_1584403_2 1123508.JH636440_gene2192 0.000285 43.9 COG0726@1|root,COG0726@2|Bacteria,2J0S7@203682|Planctomycetes 203682|Planctomycetes G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_74947_1 1380390.JIAT01000009_gene1231 1.81e-146 425.0 COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4CPID@84995|Rubrobacteria 84995|Rubrobacteria C Belongs to the citrate synthase family - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_436023_1 455436.DS989812_gene1387 1.65e-11 72.4 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,464FF@72275|Alteromonadaceae 1236|Gammaproteobacteria O Belongs to the peptidase S16 family IV02_30220 - - ko:K04770 - - - - ko00000,ko01000,ko01002 - - - AAA_32,Lon_C k59_436023_3 1234664.AMRO01000020_gene989 0.000391 43.5 COG0517@1|root,COG0517@2|Bacteria,1V9ZB@1239|Firmicutes,4HHE6@91061|Bacilli,1WGE1@129337|Geobacillus 91061|Bacilli S Domain in cystathionine beta-synthase and other proteins. ylbB - - - - - - - - - - - CBS k59_853532_1 1379270.AUXF01000003_gene3822 1.51e-61 224.0 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1ZSRY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C 4Fe-4S dicluster domain - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_1222056_2 1286106.MPL1_11633 3.13e-50 165.0 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,460PP@72273|Thiotrichales 72273|Thiotrichales S Belongs to the UPF0234 family - - - ko:K09767 - - - - ko00000 - - - DUF520 k59_649617_1 1255043.TVNIR_2992 6.47e-55 183.0 COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,1RRMX@1236|Gammaproteobacteria,1WWEJ@135613|Chromatiales 135613|Chromatiales G RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site cbbL - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N k59_649617_2 396588.Tgr7_1047 2.36e-10 60.1 COG1051@1|root,COG1051@2|Bacteria,1RC3I@1224|Proteobacteria,1S34Y@1236|Gammaproteobacteria,1WY35@135613|Chromatiales 135613|Chromatiales F NUDIX domain - - - - - - - - - - - - NUDIX k59_490772_1 1122176.KB903537_gene1639 3.99e-13 67.0 COG2940@1|root,COG2940@2|Bacteria,4NM5I@976|Bacteroidetes,1IYF0@117747|Sphingobacteriia 976|Bacteroidetes S SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain - - - - - - - - - - - - SET k59_490772_3 857087.Metme_1753 2.94e-09 58.2 COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,1S74N@1236|Gammaproteobacteria,1XF53@135618|Methylococcales 135618|Methylococcales H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA - 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_331733_1 330214.NIDE1401 5.75e-47 155.0 COG0491@1|root,COG0491@2|Bacteria 2|Bacteria GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - - - - - - - - - - Lactamase_B_5 k59_385450_1 1382356.JQMP01000003_gene1934 2.5e-62 201.0 COG0483@1|root,COG0483@2|Bacteria,2G6JD@200795|Chloroflexi,27Y5G@189775|Thermomicrobia 189775|Thermomicrobia G Inositol monophosphatase family - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_1375580_1 1238182.C882_0189 2.95e-39 142.0 COG3804@1|root,COG3804@2|Bacteria,1N3H7@1224|Proteobacteria,2VGNR@28211|Alphaproteobacteria 28211|Alphaproteobacteria S dihydrodipicolinate reductase - - - - - - - - - - - - DapB_N k59_1375580_2 1121324.CLIT_23c04070 1.55e-21 88.6 2E6IF@1|root,3315M@2|Bacteria,1VAX0@1239|Firmicutes,24N55@186801|Clostridia 186801|Clostridia - - ortA GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 2.3.1.263 ko:K21399 - - - - ko00000,ko01000 - - - - k59_1430661_1 187272.Mlg_1018 2.95e-50 176.0 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1WXYV@135613|Chromatiales 135613|Chromatiales M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella mltF GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_74958_1 1123366.TH3_12100 3.71e-59 191.0 COG1028@1|root,COG1028@2|Bacteria,1MUPY@1224|Proteobacteria,2U1ES@28211|Alphaproteobacteria,2JRNG@204441|Rhodospirillales 204441|Rhodospirillales IQ KR domain fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1584421_1 391593.RCCS2_07629 3.42e-64 216.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,2P1Q6@2433|Roseobacter 28211|Alphaproteobacteria C COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_649640_1 1144319.PMI16_04055 5.79e-56 184.0 COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2VJ5B@28216|Betaproteobacteria 28216|Betaproteobacteria S 2-Nitropropane dioxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_1430674_1 391625.PPSIR1_08511 1.29e-52 186.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_123194_1 438753.AZC_0301 2.48e-100 310.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,3EYAB@335928|Xanthobacteraceae 28211|Alphaproteobacteria F Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_490794_1 322710.Avin_16400 6.82e-82 260.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria 1236|Gammaproteobacteria I acyl-CoA dehydrogenase - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_279302_2 1408438.JADD01000021_gene409 1.52e-11 69.3 COG0740@1|root,COG0740@2|Bacteria,1TR2H@1239|Firmicutes,4HM2R@91061|Bacilli,27EV1@186827|Aerococcaceae 91061|Bacilli OU Clp protease - - - - - - - - - - - - CLP_protease k59_490795_1 945550.VISI1226_08122 1.65e-25 109.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1XTTB@135623|Vibrionales 135623|Vibrionales J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_592184_1 886293.Sinac_1690 4.97e-13 74.3 COG3119@1|root,COG3119@2|Bacteria,2J3IX@203682|Planctomycetes 203682|Planctomycetes P arylsulfatase A - - - - - - - - - - - - Sulfatase,TPR_16,TPR_19,TPR_2 k59_1062934_1 330214.NIDE0866 5.98e-65 204.0 COG2854@1|root,COG2854@2|Bacteria,3J13Z@40117|Nitrospirae 40117|Nitrospirae Q Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_1114865_1 298654.FraEuI1c_3040 1.5e-43 152.0 COG0494@1|root,COG0494@2|Bacteria,2GN6D@201174|Actinobacteria,4ESRH@85013|Frankiales 201174|Actinobacteria L PFAM NUDIX hydrolase - - - - - - - - - - - - NUDIX k59_385492_1 243231.GSU0448 1.28e-59 200.0 COG1473@1|root,COG1473@2|Bacteria,1MX6N@1224|Proteobacteria,42S5J@68525|delta/epsilon subdivisions,2WNJC@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Peptidase dimerisation domain - - - ko:K12941 - - - - ko00000,ko01002 - - - M20_dimer,Peptidase_M20 k59_220312_1 1280944.HY17_14360 2.79e-18 78.2 2BZQB@1|root,32Y98@2|Bacteria,1R3P4@1224|Proteobacteria,2UFWD@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_220312_2 631362.Thi970DRAFT_02369 4.6e-30 111.0 2DFIC@1|root,2ZRYR@2|Bacteria,1P7J0@1224|Proteobacteria,1SVFD@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_692229_1 330214.NIDE1724 7.13e-104 320.0 COG5184@1|root,COG5184@2|Bacteria 2|Bacteria DZ guanyl-nucleotide exchange factor activity - - - - - - - - - - - - Big_5,Cadherin-like,DUF3494,Glug,TIG k59_1476096_2 269482.Bcep1808_6158 2.04e-11 70.1 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,2W169@28216|Betaproteobacteria,1K5FC@119060|Burkholderiaceae 28216|Betaproteobacteria C Cytochrome c class I - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_1476096_3 1049564.TevJSym_bo00170 8.06e-27 102.0 COG2010@1|root,COG2010@2|Bacteria,1N73U@1224|Proteobacteria,1SFGZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c nirC - - ko:K19344 - - - - ko00000 - - - Cytochrome_CBB3 k59_1577902_1 1270196.JCKI01000007_gene2438 2.96e-23 95.1 COG4186@1|root,COG4186@2|Bacteria,4NMM1@976|Bacteroidetes 976|Bacteroidetes S Phosphoesterase - - - - - - - - - - - - Metallophos,Metallophos_2 k59_951066_1 545697.HMPREF0216_01862 1.35e-42 160.0 COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,36E03@31979|Clostridiaceae 186801|Clostridia J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_1422534_2 222534.KB893694_gene38 2.96e-07 53.9 COG3339@1|root,COG3339@2|Bacteria,2H67K@201174|Actinobacteria 201174|Actinobacteria S Protein of unknown function (DUF1232) - - - - - - - - - - - - DUF1232 k59_1268072_2 1207076.ALAT01000147_gene283 1.44e-44 153.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,1Z01S@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria G COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_272731_1 330214.NIDE0425 6.34e-78 238.0 COG0204@1|root,COG0204@2|Bacteria,3J16H@40117|Nitrospirae 40117|Nitrospirae I Phosphate acyltransferases - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_272731_2 330214.NIDE0424 1.68e-06 49.7 COG0283@1|root,COG0283@2|Bacteria,3J0MY@40117|Nitrospirae 40117|Nitrospirae F Belongs to the cytidylate kinase family. Type 1 subfamily cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin k59_1577907_1 755732.Fluta_2777 7.09e-07 49.7 2B04B@1|root,31SER@2|Bacteria,4PJPW@976|Bacteroidetes,1ICRV@117743|Flavobacteriia,2PBXJ@246874|Cryomorphaceae 976|Bacteroidetes S Domain of unknown function (DUF1987) - - - - - - - - - - - - DUF1987 k59_1476107_1 472759.Nhal_3177 4.24e-74 249.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_798360_1 1123033.ARNF01000053_gene991 1.06e-21 87.4 COG1983@1|root,COG1983@2|Bacteria,1NAUA@1224|Proteobacteria,1SD7E@1236|Gammaproteobacteria,3NPCM@468|Moraxellaceae 1236|Gammaproteobacteria KT PspC domain - - - - - - - - - - - - PspC k59_66775_1 1121403.AUCV01000008_gene1570 1.17e-16 85.1 COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1R891@1224|Proteobacteria,42P2C@68525|delta/epsilon subdivisions,2WJZT@28221|Deltaproteobacteria,2MIG9@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,Response_reg k59_66775_2 290397.Adeh_4279 6.21e-80 250.0 COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,42MSY@68525|delta/epsilon subdivisions,2WJXR@28221|Deltaproteobacteria,2YVAN@29|Myxococcales 28221|Deltaproteobacteria G Belongs to the UDP-N-acetylglucosamine 2-epimerase family wecB - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_1215425_1 472759.Nhal_3334 4.78e-16 83.6 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,1RXY8@1236|Gammaproteobacteria,1WW0M@135613|Chromatiales 135613|Chromatiales M PFAM lipopolysaccharide biosynthesis - - - - - - - - - - - - Wzz k59_1630995_1 1123228.AUIH01000005_gene677 2.18e-86 259.0 COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,1RRRU@1236|Gammaproteobacteria,1XHS1@135619|Oceanospirillales 135619|Oceanospirillales E phosphoserine phosphatase thrH - 2.7.1.39,3.1.3.3 ko:K02203 ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230 M00018 R00582,R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD,Hydrolase k59_1630995_2 1150626.PHAMO_340096 2.56e-12 65.1 COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2TT1U@28211|Alphaproteobacteria,2JRUZ@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) pdxH - 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - PNP_phzG_C,Putative_PNPOx k59_1577918_1 742766.HMPREF9455_04137 2.44e-25 100.0 28KU3@1|root,2ZAB1@2|Bacteria,4NHK3@976|Bacteroidetes,2FMYR@200643|Bacteroidia,22XMZ@171551|Porphyromonadaceae 976|Bacteroidetes S PcfK-like protein - - - - - - - - - - - - PcfK k59_692262_1 497321.C664_02140 3.33e-68 212.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2W1N2@28216|Betaproteobacteria,2KYCF@206389|Rhodocyclales 206389|Rhodocyclales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_1003416_1 472759.Nhal_3142 4.15e-156 473.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales 135613|Chromatiales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1316612_1 314278.NB231_09013 4.39e-49 165.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1RQ2D@1236|Gammaproteobacteria,1WXUX@135613|Chromatiales 135613|Chromatiales I 6-phosphogluconate dehydrogenase, NAD-binding - - 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_533508_1 1122603.ATVI01000008_gene2218 3.01e-63 211.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,1RMGS@1236|Gammaproteobacteria,1X37E@135614|Xanthomonadales 135614|Xanthomonadales IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_742456_1 685727.REQ_42910 3.51e-40 151.0 COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria,4FUZR@85025|Nocardiaceae 201174|Actinobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_3 k59_220355_1 566466.NOR53_2862 4.84e-12 64.7 2ECN7@1|root,32Y4C@2|Bacteria,1NEKK@1224|Proteobacteria,1SRX6@1236|Gammaproteobacteria,1JB3V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1109224_1 395493.BegalDRAFT_2608 8.46e-44 145.0 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,1S5V2@1236|Gammaproteobacteria,460WC@72273|Thiotrichales 72273|Thiotrichales J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_1109224_2 765912.Thimo_2843 4.17e-71 218.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,1RNEV@1236|Gammaproteobacteria,1WX2D@135613|Chromatiales 135613|Chromatiales J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_1216005_1 1296416.JACB01000001_gene3285 6.04e-21 88.6 COG1136@1|root,COG1136@2|Bacteria,4NNS2@976|Bacteroidetes,1I29Q@117743|Flavobacteriia,2YIK6@290174|Aquimarina 976|Bacteroidetes V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1216005_2 929556.Solca_2558 7.7e-23 98.2 COG0577@1|root,COG0577@2|Bacteria,4NF60@976|Bacteroidetes,1J0VQ@117747|Sphingobacteriia 976|Bacteroidetes V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_429917_1 314230.DSM3645_27798 6.78e-47 171.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,2IXN2@203682|Planctomycetes 203682|Planctomycetes EQ Hydantoinase B/oxoprolinase - - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_1109229_1 926569.ANT_17070 2.42e-51 172.0 COG0451@1|root,COG0451@2|Bacteria 2|Bacteria GM ADP-glyceromanno-heptose 6-epimerase activity galE5 - 4.2.1.46,5.1.3.2 ko:K01710,ko:K01784,ko:K21211 ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01059,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01059,map01100,map01130 M00361,M00362,M00632,M00793 R00291,R02984,R06513,R11430 RC00289,RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_166619_1 395494.Galf_1909 2.23e-94 299.0 COG1452@1|root,COG1452@2|Bacteria,1QW3G@1224|Proteobacteria,2WHPM@28216|Betaproteobacteria 28216|Betaproteobacteria M involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - - - - - - - - - - - k59_743108_1 338966.Ppro_0534 3.82e-104 320.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,43SXC@69541|Desulfuromonadales 28221|Deltaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_429930_1 84531.JMTZ01000101_gene1444 5.85e-17 86.7 COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,1RNZM@1236|Gammaproteobacteria,1X4Z4@135614|Xanthomonadales 135614|Xanthomonadales M protein involved in outer membrane biogenesis asmA - - ko:K07290 - - - - ko00000 9.B.121 - - AsmA k59_692941_1 713586.KB900536_gene1028 1.88e-68 221.0 COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1RPTU@1236|Gammaproteobacteria,1WXF3@135613|Chromatiales 135613|Chromatiales I Membrane protein involved in aromatic hydrocarbon degradation - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_1268889_1 1265313.HRUBRA_00640 2.33e-14 77.8 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1J5N2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state bepA GO:0003674,GO:0003756,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016787,GO:0016853,GO:0016860,GO:0016864,GO:0019538,GO:0022607,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043163,GO:0043165,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0045229,GO:0046872,GO:0051603,GO:0061024,GO:0061077,GO:0070011,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - Peptidase_M48,TPR_19 k59_1631671_1 472759.Nhal_3892 6.27e-83 270.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1WWH1@135613|Chromatiales 135613|Chromatiales M TIGRFAM penicillin-binding protein, 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_166662_1 1541065.JRFE01000024_gene790 2.43e-26 110.0 COG1216@1|root,COG1216@2|Bacteria,1G2ZC@1117|Cyanobacteria,3VJWZ@52604|Pleurocapsales 1117|Cyanobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1578636_1 1449351.RISW2_16615 2.46e-50 176.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,4KK11@93682|Roseivivax 28211|Alphaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_1578636_2 1492922.GY26_16955 2.71e-99 310.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1J4DX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceF - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_67588_1 1123242.JH636434_gene5002 8.57e-95 293.0 COG0033@1|root,COG0033@2|Bacteria,2IYG0@203682|Planctomycetes 203682|Planctomycetes G Phosphoglucomutase/phosphomannomutase, C-terminal domain - - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_534178_1 643473.KB235930_gene2989 4.07e-60 199.0 COG3288@1|root,COG3288@2|Bacteria,1G1D1@1117|Cyanobacteria,1HJ2V@1161|Nostocales 1117|Cyanobacteria C PFAM Alanine dehydrogenase PNT, C-terminal domain pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_799180_1 298654.FraEuI1c_1866 1.24e-12 69.7 COG2124@1|root,COG2124@2|Bacteria,2I9FV@201174|Actinobacteria 201174|Actinobacteria Q Cytochrome P450 - - - - - - - - - - - - p450 k59_799180_2 502025.Hoch_6537 5.1e-91 278.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,42MVI@68525|delta/epsilon subdivisions,2WPP7@28221|Deltaproteobacteria,2YUMH@29|Myxococcales 28221|Deltaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_326132_1 1441629.PCH70_12970 4.18e-117 347.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,1RN46@1236|Gammaproteobacteria,1Z6HI@136849|Pseudomonas syringae group 1236|Gammaproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_743156_1 604331.AUHY01000056_gene1303 1.61e-27 113.0 COG0119@1|root,COG0119@2|Bacteria,1WIX3@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.14 ko:K01655 ko00300,ko00620,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00620,map01100,map01120,map01130,map01210,map01230 M00030,M00433 R00271 RC00004,RC00067,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_483262_1 1206741.BAFX01000205_gene205 3.1e-44 157.0 COG4638@1|root,COG4638@2|Bacteria,2IC5G@201174|Actinobacteria,4G94M@85025|Nocardiaceae 201174|Actinobacteria P Rieske [2Fe-2S] domain vanA - - - - - - - - - - - Rieske k59_743159_1 1217720.ALOX01000010_gene2020 8.22e-11 62.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2TSKF@28211|Alphaproteobacteria,2JPW9@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_743159_2 1382306.JNIM01000001_gene2836 1.89e-75 251.0 COG0178@1|root,COG0178@2|Bacteria,2G60U@200795|Chloroflexi 200795|Chloroflexi L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_642227_1 686340.Metal_0187 1.29e-18 82.4 COG0589@1|root,COG0589@2|Bacteria,1RHE6@1224|Proteobacteria,1RVW2@1236|Gammaproteobacteria,1XFEW@135618|Methylococcales 135618|Methylococcales T Universal stress protein - - - ko:K06149 - - - - ko00000 - - - Usp k59_642227_2 631362.Thi970DRAFT_04894 5.88e-18 82.8 295V5@1|root,2ZT65@2|Bacteria,1REG0@1224|Proteobacteria,1S9HA@1236|Gammaproteobacteria,1WYWE@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_1631697_1 998088.B565_3221 8.5e-45 155.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1Y3MR@135624|Aeromonadales 135624|Aeromonadales H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate - - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_1631697_2 1198232.CYCME_0871 7.59e-57 184.0 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,460GU@72273|Thiotrichales 72273|Thiotrichales H riboflavin synthase, alpha ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_273374_1 1116472.MGMO_21c00250 9.45e-90 291.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1XEK9@135618|Methylococcales 135618|Methylococcales E Bacterial transglutaminase-like N-terminal - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_326146_1 322710.Avin_00090 4.43e-28 107.0 COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,1S3UD@1236|Gammaproteobacteria 1236|Gammaproteobacteria E D,D-heptose 1,7-bisphosphate phosphatase gmhB - 3.1.3.82,3.1.3.83 ko:K03273 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - iJN746.PP_0059 Hydrolase_like k59_326146_2 1026882.MAMP_01367 2.44e-34 133.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,45ZWF@72273|Thiotrichales 72273|Thiotrichales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_1578666_1 572480.Arnit_1614 1.48e-15 73.2 COG3439@1|root,COG3439@2|Bacteria,1RHJQ@1224|Proteobacteria,42X8S@68525|delta/epsilon subdivisions,2YQZ5@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_951854_1 98439.AJLL01000009_gene4122 4.44e-56 187.0 COG0697@1|root,COG0697@2|Bacteria,1G29Y@1117|Cyanobacteria,1JHAC@1189|Stigonemataceae 1117|Cyanobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_378017_1 330214.NIDE4207 2.43e-43 153.0 COG0463@1|root,COG0463@2|Bacteria 2|Bacteria M Glycosyl transferase, family 2 - - 2.4.1.268 ko:K21349 - - - - ko00000,ko01000 - GT81 - Glycos_transf_2 k59_378017_2 330214.NIDE4206 1.54e-44 152.0 COG0668@1|root,COG0668@2|Bacteria 2|Bacteria M transmembrane transport cmpX - - - - - - - - - - - MS_channel,TM_helix k59_483281_1 96561.Dole_1556 1.05e-99 307.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2WIJ5@28221|Deltaproteobacteria,2MHSR@213118|Desulfobacterales 28221|Deltaproteobacteria C TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit frdA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_642242_1 243231.GSU2033 7.25e-14 67.4 COG1476@1|root,COG1476@2|Bacteria,1NB6T@1224|Proteobacteria,42VWK@68525|delta/epsilon subdivisions,2WRMY@28221|Deltaproteobacteria,43VV4@69541|Desulfuromonadales 28221|Deltaproteobacteria K PFAM helix-turn-helix domain protein - - - - - - - - - - - - HTH_3 k59_221106_1 335659.S23_05530 7.24e-55 197.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_5501_1 376733.IT41_19950 5.19e-90 280.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TTAW@28211|Alphaproteobacteria,2PZC6@265|Paracoccus 28211|Alphaproteobacteria L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_115931_2 391735.Veis_1134 4.78e-41 147.0 COG1960@1|root,COG1960@2|Bacteria,1NCCF@1224|Proteobacteria,2VTAD@28216|Betaproteobacteria,4AHS9@80864|Comamonadaceae 28216|Betaproteobacteria C Acyl-CoA dehydrogenase, type 2, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1476988_1 1095750.HMPREF9970_2927 8.36e-09 58.9 COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia,1HV0Q@1164882|Lachnoanaerobaculum 186801|Clostridia C CO dehydrogenase flavoprotein C-terminal domain xdhB - 1.17.1.4 ko:K13479 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - CO_deh_flav_C,FAD_binding_5 k59_1476988_2 550540.Fbal_0926 4.49e-21 88.2 COG3686@1|root,COG3686@2|Bacteria 2|Bacteria S Membrane - - - - - - - - - - - - MAPEG k59_1423454_1 930166.CD58_20930 3.13e-79 243.0 COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,1RRRU@1236|Gammaproteobacteria 1236|Gammaproteobacteria E phosphoserine phosphatase thrH - 2.7.1.39,3.1.3.3 ko:K02203 ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230 M00018 R00582,R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD,Hydrolase k59_1485939_1 420662.Mpe_B0526 4.61e-34 129.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,1KMVQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria L DDE superfamily endonuclease - - - ko:K07494 - - - - ko00000 - - - DDE_3,HTH_23,HTH_29 k59_1432288_1 1229909.NSED_07305 1.13e-82 251.0 COG0863@1|root,arCOG00115@2157|Archaea,41SZP@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA methylase - - 2.1.1.113,2.1.1.72 ko:K00571,ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_227770_1 472759.Nhal_0673 2.25e-23 93.6 COG0517@1|root,COG0517@2|Bacteria,1QYTE@1224|Proteobacteria,1T3TX@1236|Gammaproteobacteria,1WXSV@135613|Chromatiales 135613|Chromatiales S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_227770_2 113355.CM001775_gene154 0.000435 47.8 COG0845@1|root,COG0845@2|Bacteria,1G0KI@1117|Cyanobacteria 1117|Cyanobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_125758_1 1380394.JADL01000009_gene3164 7.2e-64 212.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,2JPPV@204441|Rhodospirillales 204441|Rhodospirillales E Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_1166458_1 1265313.HRUBRA_02154 4.91e-07 52.0 COG2981@1|root,COG2981@2|Bacteria,1MVFT@1224|Proteobacteria,1RMQT@1236|Gammaproteobacteria 1236|Gammaproteobacteria U High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway cysZ GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008150,GO:0008152,GO:0008271,GO:0008272,GO:0008324,GO:0008509,GO:0008512,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009675,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015103,GO:0015116,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015296,GO:0015318,GO:0015672,GO:0015698,GO:0016020,GO:0016021,GO:0016053,GO:0019344,GO:0019752,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044425,GO:0044459,GO:0044464,GO:0046394,GO:0051179,GO:0051234,GO:0055085,GO:0071704,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0098660,GO:0098661,GO:0098662,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682,GO:1902358,GO:1902600 - ko:K06203 - - - - ko00000 - - iJR904.b2413,iYL1228.KPN_02760 EI24 k59_908181_1 1123368.AUIS01000007_gene2717 1.01e-103 321.0 COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,1S6M5@1236|Gammaproteobacteria,2NBV4@225057|Acidithiobacillales 225057|Acidithiobacillales E Oligopeptidase F - - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_173574_1 1123073.KB899243_gene547 2.49e-89 278.0 COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,1RPN7@1236|Gammaproteobacteria,1X4BQ@135614|Xanthomonadales 135614|Xanthomonadales E peptidase M20 - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_700848_1 1489678.RDMS_00915 5.02e-24 98.6 COG3335@1|root,COG3335@2|Bacteria 2|Bacteria L DDE superfamily endonuclease - - - ko:K07494 - - - - ko00000 - - - DDE_3,HTH_33 k59_78009_1 472759.Nhal_3355 6.06e-81 246.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1WXIC@135613|Chromatiales 135613|Chromatiales V PFAM ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_750925_1 1324957.K933_16707 4.94e-05 51.6 COG3119@1|root,arCOG02785@2157|Archaea,2XU9F@28890|Euryarchaeota,23TNF@183963|Halobacteria 183963|Halobacteria P COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - Sulfatase k59_493852_1 641143.HMPREF9331_01595 5.92e-06 55.1 COG1629@1|root,COG4771@2|Bacteria,4PKFM@976|Bacteroidetes,1IJQT@117743|Flavobacteriia,1ETHP@1016|Capnocytophaga 976|Bacteroidetes P TonB-dependent receptor plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1012092_1 402881.Plav_0848 3.91e-124 369.0 COG0318@1|root,COG0318@2|Bacteria,1MUIC@1224|Proteobacteria,2TRRZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II MA20_06755 - 6.2.1.3 ko:K00666,ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1012092_2 1304872.JAGC01000009_gene289 8.11e-08 58.5 COG2755@1|root,COG2755@2|Bacteria,1Q5UQ@1224|Proteobacteria,436PX@68525|delta/epsilon subdivisions,2X1C1@28221|Deltaproteobacteria,2MERH@213115|Desulfovibrionales 28221|Deltaproteobacteria E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 k59_594411_1 866774.HMPREF9248_0601 1.26e-46 161.0 COG0794@1|root,COG0794@2|Bacteria,2IE8A@201174|Actinobacteria,4CWW2@84998|Coriobacteriia 84998|Coriobacteriia M SIS domain - - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS k59_228693_1 1288826.MSNKSG1_16121 3.99e-76 244.0 COG0642@1|root,COG2205@2|Bacteria,1MXH7@1224|Proteobacteria,1RQZW@1236|Gammaproteobacteria,464FX@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1279703_1 237368.SCABRO_02835 2.49e-65 210.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,2IZ67@203682|Planctomycetes 203682|Planctomycetes O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_438588_1 329726.AM1_6090 1.41e-17 79.7 COG0500@1|root,COG2226@2|Bacteria,1GBVQ@1117|Cyanobacteria 1117|Cyanobacteria Q Nodulation protein S (NodS) - - - - - - - - - - - - - k59_125778_1 445686.E3SKU6_9CAUD 5.22e-100 327.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QI82@10662|Myoviridae 10662|Myoviridae S virus tail, fiber - - - - - - - - - - - - - k59_700866_1 1122149.BACN01000041_gene820 1.62e-51 183.0 COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,4H9WW@91061|Bacilli,3F3N8@33958|Lactobacillaceae 91061|Bacilli L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_388420_1 941449.dsx2_2410 1.27e-64 220.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2M7WE@213115|Desulfovibrionales 28221|Deltaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC pacL - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_1279708_1 864051.BurJ1DRAFT_4691 4.37e-13 70.9 COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,2VZQA@28216|Betaproteobacteria,1KNDH@119065|unclassified Burkholderiales 28216|Betaproteobacteria Q Multicopper oxidase - - 1.16.3.3 ko:K22349 - - - - ko00000,ko01000 - - - - k59_333911_1 243233.MCA0142 2.7e-66 215.0 COG0387@1|root,COG0387@2|Bacteria,1N1MR@1224|Proteobacteria,1S1GI@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Sodium/calcium exchanger protein - - - ko:K07300 - - - - ko00000,ko02000 2.A.19 - - Na_Ca_ex k59_173594_1 640081.Dsui_0994 4.44e-17 77.8 COG2802@1|root,COG2802@2|Bacteria,1RFYH@1224|Proteobacteria,2VSA4@28216|Betaproteobacteria,2KWC8@206389|Rhodocyclales 206389|Rhodocyclales S peptidase S16 - - - ko:K07157 - - - - ko00000 - - - LON_substr_bdg k59_173594_2 272560.BPSL2979 2.5e-39 145.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,1K14Y@119060|Burkholderiaceae 28216|Betaproteobacteria M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_855928_1 926549.KI421517_gene8 5.93e-15 75.1 COG0612@1|root,COG0612@2|Bacteria,4NDXM@976|Bacteroidetes,47JU2@768503|Cytophagia 976|Bacteroidetes S Belongs to the peptidase M16 family - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_1586716_1 1380600.AUYN01000009_gene1622 3.04e-26 109.0 COG0457@1|root,COG0457@2|Bacteria,4NFMI@976|Bacteroidetes,1HZPZ@117743|Flavobacteriia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_8 k59_493893_1 247633.GP2143_15936 2.21e-86 268.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1J4ST@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0306 Phosphate sulphate permeases pitA GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_1065065_1 1313172.YM304_32130 1.17e-35 134.0 COG1236@1|root,COG1236@2|Bacteria,2HEXB@201174|Actinobacteria 201174|Actinobacteria J Beta-lactamase - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL k59_9238_1 1394178.AWOO02000007_gene3247 6.49e-12 70.9 COG2271@1|root,COG2271@2|Bacteria,2I32P@201174|Actinobacteria 201174|Actinobacteria G Major facilitator Superfamily - - - ko:K08369 - - - - ko00000,ko02000 2.A.1 - - MFS_1,Sugar_tr k59_1377683_1 118173.KB235914_gene2765 4e-20 94.0 COG4122@1|root,COG4122@2|Bacteria,1G4MU@1117|Cyanobacteria,1HAKA@1150|Oscillatoriales 1117|Cyanobacteria M Methyltransferase domain - - - ko:K05303 - - - - ko00000,ko01000 - - - Glycos_transf_2,Methyltransf_23,Methyltransf_24,TylF k59_9242_1 1500890.JQNL01000001_gene2113 1.13e-42 160.0 COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RP53@1236|Gammaproteobacteria,1X55J@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg k59_652734_1 1049564.TevJSym_av00430 7.96e-78 246.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1J4CI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.98.3 ko:K02495 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R06895 RC00884 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_3134,iZ_1308.Z5403 HemN_C,Radical_SAM k59_1433716_1 1121918.ARWE01000001_gene208 3.33e-108 339.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,43RZV@69541|Desulfuromonadales 28221|Deltaproteobacteria J tRNA synthetases class I (K) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_9246_1 330214.NIDE2209 2.64e-81 255.0 COG0014@1|root,COG0014@2|Bacteria,3J0ET@40117|Nitrospirae 40117|Nitrospirae E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_959288_1 671143.DAMO_1528 3.98e-175 504.0 COG3004@1|root,COG3004@2|Bacteria,2NNWA@2323|unclassified Bacteria 2|Bacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_750974_1 1380390.JIAT01000012_gene2998 7.73e-60 206.0 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CRBA@84995|Rubrobacteria 84995|Rubrobacteria V COG COG1132 ABC-type multidrug transport system ATPase and permease components Defense mechanisms - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1377694_1 42256.RradSPS_2702 1.52e-23 103.0 COG0510@1|root,COG0510@2|Bacteria,2I4BX@201174|Actinobacteria 201174|Actinobacteria M Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_700892_1 1370125.AUWT01000029_gene503 5.84e-06 48.1 COG1545@1|root,COG1545@2|Bacteria,2GJHW@201174|Actinobacteria,2342N@1762|Mycobacteriaceae 201174|Actinobacteria S Nucleic-acid-binding protein containing a Zn-ribbon - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_493926_2 321955.AAGP01000036_gene3427 5e-29 107.0 COG1146@1|root,COG1146@2|Bacteria,2IKVN@201174|Actinobacteria,4FA6Z@85019|Brevibacteriaceae 201174|Actinobacteria C 4Fe-4S binding domain fdxA - - ko:K05524 - - - - ko00000 - - - Fer4 k59_228725_1 330214.NIDE0734 3.98e-52 174.0 COG0075@1|root,COG0075@2|Bacteria,3J0FC@40117|Nitrospirae 2|Bacteria E Evidence 2b Function of strongly homologous gene phnW GO:0003674,GO:0003824 2.5.1.49,2.6.1.37,3.11.1.1 ko:K01740,ko:K03430,ko:K05306,ko:K09469 ko00270,ko00440,ko01100,ko01120,map00270,map00440,map01100,map01120 - R00747,R01287,R04152,R04859 RC00008,RC00020,RC00062,RC00368,RC02821,RC02848 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_5 k59_228725_2 330214.NIDE0733 5.88e-32 116.0 COG0028@1|root,COG0028@2|Bacteria 2|Bacteria EH Belongs to the TPP enzyme family - - 4.1.1.82 ko:K09459 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 - R04053 RC00506 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_N k59_652752_1 1229909.NSED_05445 1.66e-32 119.0 COG0589@1|root,arCOG02053@2157|Archaea,41T8H@651137|Thaumarchaeota 651137|Thaumarchaeota T Universal stress protein family - - - - - - - - - - - - Usp k59_652752_2 1229909.NSED_05440 3.13e-45 151.0 COG0589@1|root,arCOG02053@2157|Archaea 2157|Archaea T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - 2.7.13.3 ko:K07646,ko:K20989 ko02020,map02020 M00454 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022 2.A.21.6 - - DUF4118,GAF_3,KdpD,Usp k59_652752_3 1131266.ARWQ01000002_gene438 0.00086 41.2 COG0457@1|root,COG5549@1|root,arCOG03038@2157|Archaea,arCOG04994@2157|Archaea,41T10@651137|Thaumarchaeota 651137|Thaumarchaeota O Zinc-dependent metalloprotease - - - - - - - - - - - - Peptidase_M10,TPR_8 k59_1224607_1 765914.ThisiDRAFT_2791 2.74e-26 109.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,1X0B5@135613|Chromatiales 135613|Chromatiales M Transposase zinc-binding domain - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_908249_1 1122180.Lokhon_00646 5.93e-88 272.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2TR5X@28211|Alphaproteobacteria,2P878@245186|Loktanella 28211|Alphaproteobacteria E Peptidase family M20/M25/M40 amaB GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1166502_1 398767.Glov_0695 6.64e-20 94.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2WJ54@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Lytic transglycosylase catalytic mltD2 - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_1487475_1 236097.ADG881_3292 8.86e-25 99.0 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria,1XKKG@135619|Oceanospirillales 135619|Oceanospirillales J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_1487475_2 1283284.AZUK01000001_gene628 3.36e-38 137.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1Y3M6@135624|Aeromonadales 135624|Aeromonadales J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_541762_1 95619.PM1_0226615 9.14e-60 196.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU twitching motility protein pilU - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_541762_2 203122.Sde_3640 8.34e-11 61.6 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,464R4@72275|Alteromonadaceae 1236|Gammaproteobacteria NU COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT pilT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_700908_1 1163408.UU9_08385 3.18e-16 75.5 COG0204@1|root,COG0204@2|Bacteria,1RJMS@1224|Proteobacteria,1S71V@1236|Gammaproteobacteria,1X64J@135614|Xanthomonadales 135614|Xanthomonadales I Acyltransferase - - - - - - - - - - - - Acyltransferase k59_594466_1 1288826.MSNKSG1_06683 7.52e-81 272.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,464K7@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG1643 HrpA-like helicases hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_1279790_1 1229909.NSED_03260 2.35e-68 213.0 COG1028@1|root,arCOG01259@2157|Archaea,41SXY@651137|Thaumarchaeota 651137|Thaumarchaeota I Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1279790_2 1229909.NSED_03265 5.7e-12 64.7 COG2084@1|root,arCOG00247@2157|Archaea,41SI2@651137|Thaumarchaeota 651137|Thaumarchaeota I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_228749_1 768671.ThimaDRAFT_2656 5.6e-65 213.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1WVY3@135613|Chromatiales 135613|Chromatiales S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1487506_1 1122247.C731_0918 1.13e-57 196.0 COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria,2379X@1762|Mycobacteriaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1586762_1 2340.JV46_13500 2.78e-90 283.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1J5CM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1586762_2 319003.Bra1253DRAFT_02534 1.04e-66 221.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2TW3X@28211|Alphaproteobacteria,3JW4U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria KT Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,PAS,PAS_4,Sigma54_activat k59_1065116_2 313628.LNTAR_16027 3.1e-17 77.8 COG3809@1|root,COG3809@2|Bacteria 2|Bacteria S Transcription factor zinc-finger - - - ko:K09981 - - - - ko00000 - - - Rhomboid,zf-TFIIB k59_78150_1 1123240.ATVO01000004_gene1015 8e-66 217.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria,2JZXP@204457|Sphingomonadales 204457|Sphingomonadales Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_3 k59_173640_1 1449049.JONW01000006_gene3277 1.04e-27 104.0 COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,2UDEK@28211|Alphaproteobacteria,2KGZA@204458|Caulobacterales 204458|Caulobacterales S PFAM Membrane protein of - - - ko:K08972 - - - - ko00000 - - - Phage_holin_4_2 k59_173640_2 1384056.N787_09915 3.73e-28 111.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1X2ZB@135614|Xanthomonadales 135614|Xanthomonadales M synthase cfaA - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_1322926_1 1265310.CCBD010000069_gene446 9.37e-05 45.8 COG0451@1|root,COG0451@2|Bacteria,2GN90@201174|Actinobacteria,23297@1762|Mycobacteriaceae 201174|Actinobacteria GM epimerase dehydratase - - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase k59_1322926_2 999141.GME_06839 6.05e-65 209.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1XHJ7@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_1487547_1 1132441.KI519455_gene3447 2.44e-33 129.0 COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria 201174|Actinobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_908308_1 2340.JV46_11180 2.52e-23 97.8 COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1J9XQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EH Amino-transferase class IV dat - 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 k59_908308_2 1415779.JOMH01000001_gene2568 2.64e-58 188.0 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1X4H1@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_809948_1 1123368.AUIS01000001_gene1868 3.08e-122 359.0 COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,1S11K@1236|Gammaproteobacteria,2NBQA@225057|Acidithiobacillales 225057|Acidithiobacillales E DAHP synthetase I family - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_809948_2 1216007.AOPM01000013_gene2855 6.06e-140 403.0 COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,1RP7S@1236|Gammaproteobacteria,2Q1GT@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Carbon-nitrogen hydrolase aguB - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_136570_1 1500897.JQNA01000002_gene3799 8.17e-49 168.0 COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2VI8S@28216|Betaproteobacteria,1K0C0@119060|Burkholderiaceae 28216|Betaproteobacteria G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate prpB - 5.4.2.9 ko:K01841 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 - R00661 RC02792 ko00000,ko00001,ko01000 - - - PEP_mutase k59_291566_1 189753.AXAS01000001_gene3612 3.79e-73 236.0 COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2TRPW@28211|Alphaproteobacteria,3JXN6@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1652850_1 96561.Dole_0795 7.72e-41 142.0 COG0517@1|root,COG0517@2|Bacteria,1RKZ2@1224|Proteobacteria,42SYQ@68525|delta/epsilon subdivisions,2WP9E@28221|Deltaproteobacteria,2MK65@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_1535917_1 1250232.JQNJ01000001_gene473 1.08e-77 244.0 COG0673@1|root,COG0673@2|Bacteria,4NF4Q@976|Bacteroidetes,1HZG2@117743|Flavobacteriia 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_1020964_1 1265502.KB905969_gene1227 3.17e-74 241.0 COG3563@1|root,COG3563@2|Bacteria,1MW0T@1224|Proteobacteria,2VKAF@28216|Betaproteobacteria,4AHCR@80864|Comamonadaceae 28216|Betaproteobacteria M Capsule polysaccharide biosynthesis protein wcbA - - ko:K07266 - - - - ko00000 - - - Capsule_synth k59_603176_1 1415780.JPOG01000001_gene1162 3e-21 92.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1X3KG@135614|Xanthomonadales 135614|Xanthomonadales M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_603176_2 765912.Thimo_0727 1.32e-66 225.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales 135613|Chromatiales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1235805_1 981384.AEYW01000001_gene1634 5.86e-05 44.7 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2TRUB@28211|Alphaproteobacteria,4NAKA@97050|Ruegeria 28211|Alphaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_506217_2 1449126.JQKL01000081_gene3149 2.26e-05 45.4 COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia,2688Y@186813|unclassified Clostridiales 186801|Clostridia E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_395989_1 948565.AFFP02000004_gene739 1.97e-63 205.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1Y7FP@135625|Pasteurellales 135625|Pasteurellales F synthase small subunit carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_1652876_1 266265.Bxe_C0490 1.01e-27 114.0 COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2VWYN@28216|Betaproteobacteria,1K8UX@119060|Burkholderiaceae 28216|Betaproteobacteria L Transposase IS116/IS110/IS902 family - - - ko:K07486 - - - - ko00000 - - - Transposase_20 k59_1292127_1 1267534.KB906754_gene3609 1.06e-26 107.0 COG1088@1|root,COG1088@2|Bacteria,3Y3E7@57723|Acidobacteria,2JIRI@204432|Acidobacteriia 204432|Acidobacteriia M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_968363_1 1162668.LFE_0702 8.26e-06 50.1 COG0842@1|root,COG0842@2|Bacteria,3J170@40117|Nitrospirae 40117|Nitrospirae V ABC-2 type transporter - - - ko:K01992,ko:K09694 ko02010,map02010 M00252,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.102 - - ABC2_membrane k59_291612_1 1455608.JDTH01000006_gene2645 4.28e-69 229.0 COG2217@1|root,arCOG01576@2157|Archaea,2XT3T@28890|Euryarchaeota,23S6X@183963|Halobacteria 183963|Halobacteria P copper-translocating P-type ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase k59_1075087_2 1123256.KB907929_gene3388 1.88e-138 397.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,1RR8F@1236|Gammaproteobacteria,1X4GJ@135614|Xanthomonadales 135614|Xanthomonadales L Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve,rve_3 k59_759771_1 882083.SacmaDRAFT_2369 2.03e-41 143.0 COG5424@1|root,COG5424@2|Bacteria,2I9SS@201174|Actinobacteria,4E05W@85010|Pseudonocardiales 201174|Actinobacteria H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ pqqC - 1.3.3.11 ko:K06137 - - - - ko00000,ko01000 - - - TENA_THI-4 k59_759771_2 285514.JNWO01000003_gene7065 1.93e-27 110.0 COG1235@1|root,COG1235@2|Bacteria,2HBMA@201174|Actinobacteria 201174|Actinobacteria S May be involved in the transport of PQQ or its precursor to the periplasm pqqB - - ko:K06136 - - - - ko00000 - - - Lactamase_B_2 k59_1385980_1 349521.HCH_04959 1.35e-21 99.0 28HYC@1|root,2Z83T@2|Bacteria,1QEBM@1224|Proteobacteria,1RRCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1292145_1 1123518.ARWI01000001_gene400 1.24e-109 342.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria 1236|Gammaproteobacteria V COG0577 ABC-type antimicrobial peptide transport system permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1075096_1 243230.DR_2637 1.14e-70 226.0 COG0148@1|root,COG0148@2|Bacteria,1WIST@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_1292151_1 574966.KB898647_gene2596 2.95e-28 117.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XH4Q@135619|Oceanospirillales 135619|Oceanospirillales V efflux pump - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_968379_1 713586.KB900536_gene1841 3.21e-169 517.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_506256_1 696281.Desru_0347 7.68e-39 142.0 COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia,2602H@186807|Peptococcaceae 186801|Clostridia E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1330585_1 1469557.JSWF01000028_gene2936 1.64e-11 70.9 COG2244@1|root,COG2244@2|Bacteria,4NMGP@976|Bacteroidetes,1I1VY@117743|Flavobacteriia 976|Bacteroidetes S Membrane protein involved in the export of O-antigen and teichoic acid - - - - - - - - - - - - MatE,Polysacc_synt,Polysacc_synt_C k59_1652916_1 330214.NIDE2519 5.03e-50 172.0 COG1690@1|root,COG1690@2|Bacteria,3J0X0@40117|Nitrospirae 40117|Nitrospirae S tRNA-splicing ligase RtcB rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_864868_1 404589.Anae109_4496 5.25e-38 137.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,42N8B@68525|delta/epsilon subdivisions,2WJ6I@28221|Deltaproteobacteria,2YUV1@29|Myxococcales 28221|Deltaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_864868_2 398767.Glov_3170 3.52e-27 109.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,42KZA@68525|delta/epsilon subdivisions,2WJ1V@28221|Deltaproteobacteria,43TRP@69541|Desulfuromonadales 28221|Deltaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_550637_1 338966.Ppro_3123 3.86e-26 100.0 COG3636@1|root,COG3636@2|Bacteria,1N75D@1224|Proteobacteria,42V7U@68525|delta/epsilon subdivisions,2WS0W@28221|Deltaproteobacteria,43W28@69541|Desulfuromonadales 28221|Deltaproteobacteria K addiction module antidote protein - - - - - - - - - - - - - k59_506278_1 349161.Dred_0722 3.36e-86 269.0 COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,2492A@186801|Clostridia,2608E@186807|Peptococcaceae 186801|Clostridia E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_864880_1 426355.Mrad2831_5936 6.99e-39 137.0 2DNM2@1|root,32Y26@2|Bacteria,1N7KR@1224|Proteobacteria,2UI2G@28211|Alphaproteobacteria,1JVBG@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Lipocalin-like domain - - - - - - - - - - - - Lipocalin_5 k59_1652932_2 405948.SACE_4237 1.2e-59 210.0 COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,2GIZP@201174|Actinobacteria,4DZJ9@85010|Pseudonocardiales 201174|Actinobacteria I Acetyl propionyl-CoA carboxylase, alpha subunit - - - - - - - - - - - - ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans k59_1330600_1 686340.Metal_0835 1.21e-126 375.0 COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,1RPYD@1236|Gammaproteobacteria,1XENF@135618|Methylococcales 135618|Methylococcales S Bacterial protein of unknown function (DUF853) - - - ko:K06915 - - - - ko00000 - - - DUF853 k59_1075136_1 706587.Desti_3122 2.29e-25 104.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2MQAH@213462|Syntrophobacterales 28221|Deltaproteobacteria U Type II secretion system (T2SS), protein F pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_1075136_2 338966.Ppro_2513 3.21e-93 283.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,43TEX@69541|Desulfuromonadales 28221|Deltaproteobacteria NU Type II/IV secretion system protein pilT-4 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_343874_1 616991.JPOO01000003_gene1025 7.99e-33 125.0 COG0004@1|root,COG0004@2|Bacteria,4NDV2@976|Bacteroidetes,1HYDV@117743|Flavobacteriia,23H6E@178469|Arenibacter 976|Bacteroidetes P Ammonium Transporter Family - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_237715_1 1229909.NSED_02715 9.18e-41 140.0 arCOG08683@1|root,arCOG08683@2157|Archaea,41SUM@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1127317_1 566466.NOR53_1750 8.36e-95 293.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1J7KH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_1499755_1 1121918.ARWE01000001_gene411 1.33e-10 62.0 COG0377@1|root,COG0649@1|root,COG0377@2|Bacteria,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,43S0B@69541|Desulfuromonadales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoBCD GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K13378,ko:K13380 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa,Oxidored_q6 k59_1499755_2 443144.GM21_4007 1.28e-53 181.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00333,ko:K13378,ko:K13380 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases k59_1536810_1 314278.NB231_10393 2.18e-85 270.0 COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,1RNFJ@1236|Gammaproteobacteria,1WWXB@135613|Chromatiales 135613|Chromatiales T PFAM PrkA AAA - - - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_137998_1 765914.ThisiDRAFT_0775 1.18e-71 226.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1WWNZ@135613|Chromatiales 135613|Chromatiales K Belongs to the ParB family - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_137998_2 2340.JV46_17370 7.72e-134 387.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1J4Z2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666 ATP-synt_A k59_137998_4 323850.Shew_3849 2.68e-20 84.7 COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,1S402@1236|Gammaproteobacteria,2QADG@267890|Shewanellaceae 1236|Gammaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpF GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - e_coli_core.b3736,iAF1260.b3736,iB21_1397.B21_03564,iBWG_1329.BWG_3427,iE2348C_1286.E2348C_4046,iEC042_1314.EC042_4123,iEC55989_1330.EC55989_4211,iECABU_c1320.ECABU_c42210,iECBD_1354.ECBD_4296,iECB_1328.ECB_03620,iECDH10B_1368.ECDH10B_3923,iECDH1ME8569_1439.ECDH1ME8569_3624,iECD_1391.ECD_03620,iECED1_1282.ECED1_4426,iECH74115_1262.ECH74115_5172,iECIAI1_1343.ECIAI1_3920,iECIAI39_1322.ECIAI39_4340,iECO103_1326.ECO103_4422,iECO111_1330.ECO111_4570,iECO26_1355.ECO26_4842,iECOK1_1307.ECOK1_4185,iECP_1309.ECP_3935,iECS88_1305.ECS88_4158,iECSE_1348.ECSE_4026,iECSF_1327.ECSF_3584,iECSP_1301.ECSP_4786,iECUMN_1333.ECUMN_4266,iECW_1372.ECW_m4039,iECs_1301.ECs4678,iEKO11_1354.EKO11_4609,iETEC_1333.ETEC_4027,iEcDH1_1363.EcDH1_4231,iEcE24377_1341.EcE24377A_4252,iEcHS_1320.EcHS_A3952,iEcSMS35_1347.EcSMS35_4104,iEcolC_1368.EcolC_4258,iG2583_1286.G2583_4532,iJO1366.b3736,iJR904.b3736,iSDY_1059.SDY_4012,iSFV_1184.SFV_3762,iSF_1195.SF3816,iSFxv_1172.SFxv_4159,iSSON_1240.SSON_3883,iS_1188.S3952,iSbBS512_1146.SbBS512_E4185,iUMN146_1321.UM146_18870,iUMNK88_1353.UMNK88_4548,iUTI89_1310.UTI89_C4291,iWFL_1372.ECW_m4039,iY75_1357.Y75_RS18390,iZ_1308.Z5234,ic_1306.c4664 ATP-synt_B k59_551687_1 1150864.MILUP08_46373 2.86e-09 60.8 COG2211@1|root,COG2211@2|Bacteria,2HD4Y@201174|Actinobacteria,4D9QN@85008|Micromonosporales 201174|Actinobacteria G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_1654375_1 1229909.NSED_00900 2.37e-59 188.0 COG0071@1|root,arCOG01832@2157|Archaea,41T6B@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_1445484_2 172045.KS04_13130 2.51e-48 158.0 COG5646@1|root,COG5646@2|Bacteria,4NP13@976|Bacteroidetes,1I243@117743|Flavobacteriia,34RCF@308865|Elizabethkingia 976|Bacteroidetes S Domain of unknown function (DU1801) - - - - - - - - - - - - DUF1801 k59_666603_1 298654.FraEuI1c_1214 1.08e-42 159.0 COG1028@1|root,COG2070@1|root,COG3321@1|root,COG1028@2|Bacteria,COG2070@2|Bacteria,COG3321@2|Bacteria,2H477@201174|Actinobacteria,4EU82@85013|Frankiales 201174|Actinobacteria Q Beta-ketoacyl synthase - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NMO,PP-binding,PS-DH,ketoacyl-synt k59_1386927_1 331869.BAL199_16693 1.65e-75 228.0 COG0346@1|root,COG0346@2|Bacteria,1RIUN@1224|Proteobacteria,2U9CD@28211|Alphaproteobacteria 28211|Alphaproteobacteria E glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_450956_1 330214.NIDE0362 5e-100 308.0 COG0445@1|root,COG0445@2|Bacteria,3J0E9@40117|Nitrospirae 40117|Nitrospirae D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_969434_1 396588.Tgr7_2043 6.87e-135 395.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,1WWTQ@135613|Chromatiales 135613|Chromatiales E PFAM aminotransferase, class I - - - - - - - - - - - - Aminotran_1_2 k59_1021976_1 999630.TUZN_1476 3.39e-16 75.1 COG3357@1|root,arCOG04479@2157|Archaea,2XR5D@28889|Crenarchaeota 28889|Crenarchaeota K transcriptional regulator containing an HTH domain fused to a Zn-ribbon - - - ko:K07743 - - - - ko00000 - - - - k59_1021976_2 1183438.GKIL_2953 1.11e-44 150.0 COG1670@1|root,COG1670@2|Bacteria,1G621@1117|Cyanobacteria 1117|Cyanobacteria J PFAM Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_3 k59_138020_1 391595.RLO149_c037000 2.02e-37 139.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_3 k59_1175214_1 1380390.JIAT01000010_gene4238 1.35e-182 530.0 COG0318@1|root,COG0318@2|Bacteria,2GKDF@201174|Actinobacteria,4CPC4@84995|Rubrobacteria 84995|Rubrobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1175214_2 1299327.I546_7022 3.32e-44 150.0 COG1028@1|root,COG1028@2|Bacteria,2GNUM@201174|Actinobacteria,234YE@1762|Mycobacteriaceae 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short,adh_short_C2 k59_865819_1 485913.Krac_5171 0.000119 48.9 COG0542@1|root,COG1595@1|root,COG0542@2|Bacteria,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088,ko:K03696 ko01100,map01100 - - - ko00000,ko03021,ko03110 - - - Clp_N,Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_1237216_1 344747.PM8797T_23971 7.64e-107 322.0 COG0389@1|root,COG0389@2|Bacteria,2IZ2I@203682|Planctomycetes 203682|Planctomycetes L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_1237216_2 1288494.EBAPG3_25050 3.09e-54 180.0 COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,2VMRG@28216|Betaproteobacteria,372J6@32003|Nitrosomonadales 28216|Betaproteobacteria G Fructose-bisphosphate aldolase class-I fbaB - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic k59_345093_1 1122137.AQXF01000004_gene1723 1.64e-68 224.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,2TRCZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Oligopeptide transporter OPT - - - - - - - - - - - - OPT k59_1386948_1 1047013.AQSP01000037_gene1322 1.33e-29 120.0 COG0531@1|root,COG0531@2|Bacteria 2|Bacteria E amino acid - - - ko:K03294,ko:K13868 ko04974,map04974 - - - ko00000,ko00001,ko02000 2.A.3.2,2.A.3.8.15 - - AA_permease_2 k59_920047_1 1300345.LF41_848 4.25e-25 105.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X2Z4@135614|Xanthomonadales 135614|Xanthomonadales T phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,HAMP,dCache_3 k59_1175234_1 521460.Athe_2046 8.22e-06 52.4 COG1484@1|root,COG1484@2|Bacteria,1TPKM@1239|Firmicutes,2483D@186801|Clostridia,42GBA@68295|Thermoanaerobacterales 186801|Clostridia L SMART AAA ATPase dnaC - - ko:K02315 - - - - ko00000,ko03032 - - - IstB_IS21 k59_1293614_1 330214.NIDE0960 1.36e-66 216.0 COG4122@1|root,COG4122@2|Bacteria,3J0XW@40117|Nitrospirae 40117|Nitrospirae S Pup-ligase protein - - 6.3.1.19 ko:K13571 - M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 - - - Pup_ligase k59_969459_1 631362.Thi970DRAFT_02202 5.39e-90 274.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1WWB3@135613|Chromatiales 135613|Chromatiales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_1151011_1 247490.KSU1_D0783 1.97e-61 202.0 COG0803@1|root,COG0803@2|Bacteria,2J0IP@203682|Planctomycetes 203682|Planctomycetes P Zinc-uptake complex component A periplasmic - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_210995_1 28737.XP_006898590.1 4.73e-19 86.3 COG0484@1|root,KOG0714@2759|Eukaryota,38BTN@33154|Opisthokonta,3BCDV@33208|Metazoa,3CTA3@33213|Bilateria,4846N@7711|Chordata,493F9@7742|Vertebrata,3J3ZS@40674|Mammalia,34WNP@311790|Afrotheria 33208|Metazoa O homolog, subfamily B, member 5 DNAJB5 GO:0000122,GO:0002682,GO:0002684,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0006457,GO:0006950,GO:0006986,GO:0008134,GO:0008150,GO:0008593,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010646,GO:0010648,GO:0019219,GO:0019222,GO:0023051,GO:0023057,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031647,GO:0035966,GO:0042221,GO:0042689,GO:0042691,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0045595,GO:0045597,GO:0045610,GO:0045612,GO:0045746,GO:0045892,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050793,GO:0050794,GO:0050821,GO:0050896,GO:0051082,GO:0051087,GO:0051094,GO:0051171,GO:0051172,GO:0051239,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K09507,ko:K09510,ko:K09511 ko04141,ko05164,map04141,map05164 - - - ko00000,ko00001,ko03110 - - - DnaJ,DnaJ_C k59_210995_2 279714.FuraDRAFT_2622 6.59e-154 452.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,2KPV9@206351|Neisseriales 28216|Betaproteobacteria O Heat shock 70 kDa protein - - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_315564_1 1396141.BATP01000059_gene2541 5.62e-11 68.2 COG1450@1|root,COG1450@2|Bacteria,46UJ6@74201|Verrucomicrobia,2IU06@203494|Verrucomicrobiae 203494|Verrucomicrobiae NU Bacterial type II/III secretion system short domain - - - - - - - - - - - - Secretin,Secretin_N k59_942033_1 926550.CLDAP_06280 2.2e-138 406.0 COG2141@1|root,COG3255@1|root,COG2141@2|Bacteria,COG3255@2|Bacteria,2G878@200795|Chloroflexi 200795|Chloroflexi C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_524418_1 235909.GK2556 1.85e-29 121.0 COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,4H9XC@91061|Bacilli,1WFM3@129337|Geobacillus 91061|Bacilli J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_524418_2 745014.OMB55_00015170 4.09e-14 71.6 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1J4D1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the aspartokinase family lysC GO:0003674,GO:0003824,GO:0004072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0044237 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_263300_1 1117647.M5M_03600 5.28e-87 265.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RMAX@1236|Gammaproteobacteria,1J4DY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_629390_1 247490.KSU1_B0005 2.48e-43 157.0 COG0618@1|root,COG0618@2|Bacteria,2IYQ0@203682|Planctomycetes 203682|Planctomycetes S phosphoesterase RecJ domain protein - - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_1455_1 314278.NB231_09903 7.84e-64 216.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1WX9W@135613|Chromatiales 135613|Chromatiales P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_471792_1 504832.OCAR_6432 7.47e-44 154.0 COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2TR65@28211|Alphaproteobacteria,3JTI5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P cation efflux czcD - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux k59_471792_2 383372.Rcas_2442 8.51e-100 301.0 COG0673@1|root,COG0673@2|Bacteria,2G8AZ@200795|Chloroflexi 200795|Chloroflexi S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_942045_2 640081.Dsui_0674 2.2e-32 123.0 COG3087@1|root,COG3087@2|Bacteria,1RI6A@1224|Proteobacteria,2VR10@28216|Betaproteobacteria,2KWVJ@206389|Rhodocyclales 206389|Rhodocyclales D cell division protein ftsN - - - - - - - - - - - SPOR k59_158120_1 58344.JOEL01000012_gene2544 1.81e-60 197.0 COG2141@1|root,COG2141@2|Bacteria,2GJTP@201174|Actinobacteria 201174|Actinobacteria C F420-dependent oxidoreductase - - - - - - - - - - - - Bac_luciferase k59_54814_2 1122603.ATVI01000005_gene2979 6.99e-19 90.1 COG2159@1|root,COG2159@2|Bacteria,1QDV1@1224|Proteobacteria,1RYCT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Amidohydrolase - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_576513_1 794903.OPIT5_07415 2.98e-76 238.0 COG1899@1|root,COG1899@2|Bacteria,46T9G@74201|Verrucomicrobia,3K7VQ@414999|Opitutae 414999|Opitutae O Deoxyhypusine synthase - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS k59_994217_1 436308.Nmar_1293 1.23e-117 345.0 COG0119@1|root,arCOG02092@2157|Archaea,41S7Y@651137|Thaumarchaeota 651137|Thaumarchaeota E HMGL-like - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_1256122_1 439235.Dalk_0409 4.35e-20 95.9 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2WJB0@28221|Deltaproteobacteria,2MIV2@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_1099154_1 106370.Francci3_0216 6.68e-64 200.0 COG0288@1|root,COG0288@2|Bacteria,2GM1M@201174|Actinobacteria,4ESIB@85013|Frankiales 201174|Actinobacteria P Reversible hydration of carbon dioxide mtcA1 GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008270,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_1099154_2 1123508.JH636440_gene2408 1.96e-06 47.8 COG0818@1|root,COG0818@2|Bacteria,2J1DU@203682|Planctomycetes 203682|Planctomycetes M Diacylglycerol kinase - - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar k59_419972_1 330214.NIDE4284 9.48e-52 168.0 COG0546@1|root,COG0546@2|Bacteria,3J0QE@40117|Nitrospirae 40117|Nitrospirae S HAD-hyrolase-like - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_419972_2 330214.NIDE4283 0.000153 46.6 COG0612@1|root,COG0612@2|Bacteria,3J0BY@40117|Nitrospirae 2|Bacteria S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology pqqL - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_525076_1 1245471.PCA10_03470 4.25e-66 226.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1YEZ2@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Signal transducing histidine kinase, homodimeric domain chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1047485_2 395493.BegalDRAFT_1091 1.12e-33 124.0 COG1309@1|root,COG1309@2|Bacteria,1N0XU@1224|Proteobacteria,1S91U@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - - - - - - - - - - TetR_N,WHG k59_682459_1 1232410.KI421416_gene2598 5.09e-57 199.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NGS@68525|delta/epsilon subdivisions,2WIWF@28221|Deltaproteobacteria,43TQ3@69541|Desulfuromonadales 28221|Deltaproteobacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_577212_1 330214.NIDE3182 3.38e-129 383.0 COG0205@1|root,COG0205@2|Bacteria,3J0Y1@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions - - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_1151697_1 1123322.KB904669_gene3530 3.23e-12 69.3 COG0300@1|root,COG0596@1|root,COG0300@2|Bacteria,COG0596@2|Bacteria,2I2RM@201174|Actinobacteria 201174|Actinobacteria I Belongs to the short-chain dehydrogenases reductases (SDR) family ephD - - - - - - - - - - - Abhydrolase_1,adh_short k59_1151697_2 326424.FRAAL4909 6.08e-11 62.8 COG0494@1|root,COG0494@2|Bacteria,2II41@201174|Actinobacteria,4EVKE@85013|Frankiales 201174|Actinobacteria L Belongs to the Nudix hydrolase family - - - - - - - - - - - - NUDIX k59_55619_1 330214.NIDE2781 7.56e-73 235.0 COG1032@1|root,COG1032@2|Bacteria 2|Bacteria C radical SAM domain protein - - - - - - - - - - - - B12-binding,PqqD,Radical_SAM k59_1360983_1 330214.NIDE3279 1.37e-87 266.0 COG3381@1|root,COG3381@2|Bacteria 2|Bacteria S protein complex oligomerization - - - - - - - - - - - - Nitrate_red_del k59_158576_1 1249627.D779_1814 1.77e-26 107.0 COG3773@1|root,COG3773@2|Bacteria,1MWX3@1224|Proteobacteria,1S73A@1236|Gammaproteobacteria,1WYN0@135613|Chromatiales 135613|Chromatiales M PFAM Cell wall hydrolase - - - - - - - - - - - - Hydrolase_2 k59_1099842_1 1206739.BAGJ01000133_gene855 1.05e-120 356.0 COG1960@1|root,COG1960@2|Bacteria,2GJX5@201174|Actinobacteria,4FXG8@85025|Nocardiaceae 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain fadE12_3 - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1569533_1 886293.Sinac_2688 4.2e-108 326.0 COG3379@1|root,COG3379@2|Bacteria,2IYF3@203682|Planctomycetes 2|Bacteria P Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_525093_1 640081.Dsui_3125 9.42e-63 209.0 COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2VIU7@28216|Betaproteobacteria,2KU6N@206389|Rhodocyclales 206389|Rhodocyclales C cytochrome nirN - - - - - - - - - - - Cytochrom_D1,Cytochrome_CBB3 k59_1465541_1 1229909.NSED_09210 6.48e-38 134.0 COG1047@1|root,arCOG00980@2157|Archaea,41T0T@651137|Thaumarchaeota 651137|Thaumarchaeota O Peptidyl-prolyl cis-trans - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - FKBP_C k59_1465541_2 1229909.NSED_09205 2.86e-61 197.0 COG0371@1|root,arCOG00982@2157|Archaea,41T0B@651137|Thaumarchaeota 651137|Thaumarchaeota C Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea egsA - 1.1.1.261 ko:K00096 ko00564,map00564 - R05679,R05680 RC00029 ko00000,ko00001,ko01000 - - - Fe-ADH_2 k59_577225_1 1448139.AI20_10410 4.37e-20 83.2 2END2@1|root,33G0J@2|Bacteria,1NIFI@1224|Proteobacteria,1SHCA@1236|Gammaproteobacteria,1Y6AM@135624|Aeromonadales 135624|Aeromonadales - - - - - - - - - - - - - - - k59_577225_2 640081.Dsui_1896 1.11e-18 87.0 COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2VHCU@28216|Betaproteobacteria,2KVU1@206389|Rhodocyclales 206389|Rhodocyclales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_525095_1 665571.STHERM_c01880 2.96e-07 53.5 COG0664@1|root,COG0664@2|Bacteria 2|Bacteria T cyclic nucleotide binding - GO:0000166,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0017076,GO:0019219,GO:0019222,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0046983,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_525095_2 331869.BAL199_23974 1.98e-79 250.0 COG0006@1|root,COG0006@2|Bacteria,1R9IK@1224|Proteobacteria 1224|Proteobacteria E peptidase M24 - - - - - - - - - - - - Creatinase_N,Peptidase_M24 k59_1622104_1 1196029.ALIM01000014_gene2852 4.46e-20 94.4 COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,4H9XC@91061|Bacilli,1ZB9E@1386|Bacillus 91061|Bacilli J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_420684_1 272558.10174137 1.45e-54 180.0 COG0702@1|root,COG0702@2|Bacteria,1TQFS@1239|Firmicutes,4HDA2@91061|Bacilli,1ZBH3@1386|Bacillus 91061|Bacilli GM NmrA-like family yhfK_2 - - - - - - - - - - - NAD_binding_10 k59_420684_2 1101189.AQUO01000003_gene3839 1.32e-12 66.6 COG0075@1|root,COG0075@2|Bacteria,1R4JQ@1224|Proteobacteria,2TV9E@28211|Alphaproteobacteria,2PVWP@265|Paracoccus 28211|Alphaproteobacteria E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 k59_1412797_1 1122135.KB893146_gene1489 4.72e-09 59.3 COG0204@1|root,COG1647@1|root,COG0204@2|Bacteria,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria 1224|Proteobacteria I esterase lipase - - - - - - - - - - - - Acyltransferase,Hydrolase_4 k59_942720_1 335543.Sfum_1225 5.39e-67 228.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2MQUW@213462|Syntrophobacterales 28221|Deltaproteobacteria L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_316355_1 795359.TOPB45_0396 1.82e-16 80.9 COG0685@1|root,COG0685@2|Bacteria 2|Bacteria E methylenetetrahydrofolate reductase (NAD(P)H) activity metF3 - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_1308323_1 251221.35212497 1.2e-60 209.0 COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,1GC0D@1117|Cyanobacteria 1117|Cyanobacteria G PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - - k59_1361001_1 207559.Dde_1819 9.19e-11 63.5 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,42M2H@68525|delta/epsilon subdivisions,2WJ8I@28221|Deltaproteobacteria,2M7R1@213115|Desulfovibrionales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_1361001_2 1121935.AQXX01000135_gene3659 1.96e-39 145.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1XHAC@135619|Oceanospirillales 135619|Oceanospirillales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_786911_1 909663.KI867150_gene213 8.37e-49 179.0 COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria,2MRCI@213462|Syntrophobacterales 28221|Deltaproteobacteria M PFAM Tetratricopeptide repeat - - - - - - - - - - - - PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_890936_2 570967.JMLV01000001_gene2824 1.57e-28 119.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,2JPM5@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the binding-protein-dependent transport system permease family livM - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2,DUF3382 k59_264018_2 526227.Mesil_3298 3.29e-40 146.0 COG0174@1|root,COG0174@2|Bacteria,1WM8G@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_994895_1 198804.BUsg_223 3.97e-25 105.0 COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,1RPCS@1236|Gammaproteobacteria,37CWV@32199|Buchnera 1236|Gammaproteobacteria E N-succinyltransferase activity dapD GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008666,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - iSbBS512_1146.SbBS512_E0158 Hexapep,Hexapep_2,THDPS_N_2 k59_682494_1 887898.HMPREF0551_1824 6.86e-19 85.5 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VHBS@28216|Betaproteobacteria,1K1JH@119060|Burkholderiaceae 28216|Betaproteobacteria M peptidase - - - - - - - - - - - - Peptidase_M23 k59_682494_2 868864.Dester_1159 7.97e-60 191.0 COG0503@1|root,COG0503@2|Bacteria,2G4K7@200783|Aquificae 200783|Aquificae F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k59_1361006_1 626887.J057_04751 1.66e-38 135.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,466I4@72275|Alteromonadaceae 1236|Gammaproteobacteria F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2813,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193 Guanylate_kin k59_682495_1 1177154.Y5S_02831 4.44e-05 51.2 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XHRM@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the peptidase S1C family mucD GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_630284_1 1318628.MARLIPOL_09621 8.44e-25 115.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,4650G@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1256988_1 472759.Nhal_2631 6.51e-08 54.3 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1WWFA@135613|Chromatiales 135613|Chromatiales E PFAM Prephenate dehydratase - - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_1256988_2 1049564.TevJSym_ad01420 1.68e-73 232.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1J5JA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_630295_1 653045.Strvi_6283 6.33e-05 49.7 COG0500@1|root,COG2226@2|Bacteria,2I3AK@201174|Actinobacteria 201174|Actinobacteria Q Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_25 k59_734131_1 404380.Gbem_2959 2.02e-19 90.5 COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,42TE9@68525|delta/epsilon subdivisions,2WPGF@28221|Deltaproteobacteria,43SXV@69541|Desulfuromonadales 28221|Deltaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short k59_1256999_1 351607.Acel_2015 4.51e-57 184.0 COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4ES6F@85013|Frankiales 201174|Actinobacteria L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - HHH,RecR,Toprim_4 k59_420710_1 556269.ACDQ01000019_gene785 3.35e-15 78.6 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2VH47@28216|Betaproteobacteria,472JW@75682|Oxalobacteraceae 28216|Betaproteobacteria E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_420710_3 1121948.AUAC01000004_gene184 1.16e-09 60.5 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2TQPB@28211|Alphaproteobacteria,43WZD@69657|Hyphomonadaceae 28211|Alphaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4,4.1.1.20 ko:K01586,ko:K12526 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00525,M00526,M00527 R00451,R00480 RC00002,RC00043,RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_106923_1 1121939.L861_04720 1.73e-96 294.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria 1236|Gammaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine - - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_682527_1 666681.M301_2380 4.36e-45 161.0 COG4398@1|root,COG4398@2|Bacteria,1RBRR@1224|Proteobacteria,2VQ7K@28216|Betaproteobacteria,2KMA1@206350|Nitrosomonadales 206350|Nitrosomonadales S FIST_C - - - - - - - - - - - - FIST,FIST_C k59_734147_1 1183438.GKIL_0112 2.81e-16 84.0 COG0475@1|root,COG0475@2|Bacteria,1G03Z@1117|Cyanobacteria 1117|Cyanobacteria P PFAM Sodium hydrogen exchanger family kefB - - - - - - - - - - - Na_H_Exchanger k59_316412_1 1232410.KI421425_gene1545 1.13e-21 89.4 COG0848@1|root,COG0848@2|Bacteria,1N8FU@1224|Proteobacteria,42WU3@68525|delta/epsilon subdivisions,2WSMD@28221|Deltaproteobacteria,43UYT@69541|Desulfuromonadales 28221|Deltaproteobacteria U Biopolymer transport protein ExbD/TolR - - - - - - - - - - - - ExbD k59_682534_1 172088.AUGA01000040_gene5046 3.6e-66 213.0 COG4307@1|root,COG4307@2|Bacteria,1MXES@1224|Proteobacteria,2U06R@28211|Alphaproteobacteria,3JRXQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Putative zinc-binding metallo-peptidase - - - - - - - - - - - - Peptidase_Mx k59_264061_2 234267.Acid_3530 2.14e-20 92.4 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - Sortilin-Vps10 k59_1204884_1 933262.AXAM01000009_gene1488 1.19e-75 226.0 COG1146@1|root,COG1146@2|Bacteria,1RC9N@1224|Proteobacteria,42QXF@68525|delta/epsilon subdivisions,2WMRJ@28221|Deltaproteobacteria,2MJFT@213118|Desulfobacterales 28221|Deltaproteobacteria C reductase, beta subunit aprB - 1.8.99.2 ko:K00395 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 - - - APS-reductase_C,Fer4,Fer4_9 k59_1257036_1 858215.Thexy_0485 1.62e-36 140.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,42F02@68295|Thermoanaerobacterales 186801|Clostridia K transcriptional regulator - - - - - - - - - - - - FeS,Fe_hyd_lg_C,HTH_8,PAS,PAS_9,PTS-HPr,Sigma54_activat k59_66109_1 76114.ebA2089 1.35e-51 171.0 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2VHIK@28216|Betaproteobacteria,2KW06@206389|Rhodocyclales 206389|Rhodocyclales O XdhC Rossmann domain - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_66109_2 1123229.AUBC01000015_gene4715 2.22e-05 43.9 COG1975@1|root,COG1975@2|Bacteria,1RI4U@1224|Proteobacteria,2U9FQ@28211|Alphaproteobacteria,3JYQ5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O XdhC and CoxI family MA20_09410 - - - - - - - - - - - XdhC_CoxI k59_899098_1 742740.HMPREF9474_02621 1.49e-12 70.5 COG2084@1|root,COG2084@2|Bacteria,1V4MC@1239|Firmicutes,24KB8@186801|Clostridia 186801|Clostridia I Domain of unknown function (DUF1932) - - - - - - - - - - - - DUF1932,NAD_binding_2 k59_899098_2 1211115.ALIQ01000198_gene463 3.1e-59 196.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,3NAJC@45404|Beijerinckiaceae 28211|Alphaproteobacteria CE Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_5004_1 1487953.JMKF01000028_gene1222 1.09e-45 160.0 COG0604@1|root,COG0604@2|Bacteria,1FZW8@1117|Cyanobacteria,1H6ZN@1150|Oscillatoriales 1117|Cyanobacteria C COG0604 NADPH quinone reductase and related Zn-dependent - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N_2 k59_272201_1 1049564.TevJSym_aj00600 1.01e-97 304.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1J4FF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527 DXP_synthase_N,Transket_pyr,Transketolase_C k59_1214840_1 396588.Tgr7_1275 3.1e-85 261.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1WWD8@135613|Chromatiales 135613|Chromatiales O Belongs to the HypD family - - - ko:K04654 - - - - ko00000 - - - HypD k59_1214840_2 876269.ARWA01000001_gene3252 0.000799 42.4 COG2215@1|root,COG2215@2|Bacteria,1R3QK@1224|Proteobacteria,2U11V@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the NiCoT transporter (TC 2.A.52) family - - - - - - - - - - - - DsbD_2,NicO k59_1108030_1 713586.KB900536_gene2898 4.49e-92 282.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales 135613|Chromatiales C Cysteine-rich domain - - - - - - - - - - - - CCG k59_1108030_2 765913.ThidrDRAFT_3039 3.3e-16 75.1 COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria,1WX78@135613|Chromatiales 135613|Chromatiales C Protein of unknown function (DUF3501) - - - - - - - - - - - - DUF3501 k59_741928_1 404589.Anae109_0440 3.13e-73 236.0 COG1638@1|root,COG1638@2|Bacteria,1PJFW@1224|Proteobacteria,42PXK@68525|delta/epsilon subdivisions,2WJFU@28221|Deltaproteobacteria,2Z1WI@29|Myxococcales 28221|Deltaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_741928_2 335543.Sfum_2673 3.8e-98 297.0 COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,42Q81@68525|delta/epsilon subdivisions,2WIJ3@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TRAP transporter T-component - - - - - - - - - - - - TAtT k59_219811_1 754059.M1PRW7_9CAUD 2.61e-15 76.3 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QNBD@10744|Podoviridae 10744|Podoviridae S outer membrane - - - - - - - - - - - - - k59_219811_2 1316927.ATKI01000032_gene4867 1.06e-10 65.1 COG0689@1|root,COG2931@1|root,COG0689@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1YSF7@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria Q Pectate lyase superfamily protein psmE - - - - - - - - - - - Beta_helix,Cadherin_3,DUF4114,He_PIG,HemolysinCabind,Pectate_lyase_3,Peptidase_M10,Peptidase_M10_C k59_1475452_1 396588.Tgr7_0661 5.62e-09 57.0 COG0412@1|root,COG0412@2|Bacteria,1RCWF@1224|Proteobacteria,1RY38@1236|Gammaproteobacteria,1WX5X@135613|Chromatiales 135613|Chromatiales Q PFAM Dienelactone hydrolase - - - - - - - - - - - - DLH k59_219815_1 1469613.JT55_13870 3.88e-05 45.4 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,3FCMQ@34008|Rhodovulum 28211|Alphaproteobacteria E ATPases associated with a variety of cellular activities bztD - 3.6.3.21 ko:K02028,ko:K09972 ko02010,map02010 M00232,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - ABC_tran k59_219815_2 1279015.KB908454_gene716 2.01e-108 324.0 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,1RPJR@1236|Gammaproteobacteria,1Y3Z1@135624|Aeromonadales 135624|Aeromonadales E Binding-protein-dependent transport system inner membrane component - - - ko:K09971 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_1214855_1 1449065.JMLL01000013_gene2730 4.27e-10 63.5 COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria 1224|Proteobacteria KT ankyrin repeat - - - - - - - - - - - - Ank,Ank_2,Ank_4,Ank_5 k59_846684_1 517418.Ctha_0743 6.11e-106 338.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1FDJW@1090|Chlorobi 1090|Chlorobi C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_324933_1 472759.Nhal_2510 2.65e-141 409.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1WX3U@135613|Chromatiales 135613|Chromatiales C PFAM Alcohol dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_1475475_1 887898.HMPREF0551_1430 1.2e-111 340.0 COG0028@1|root,COG0028@2|Bacteria,1MWUB@1224|Proteobacteria,2VMC1@28216|Betaproteobacteria,1K2XV@119060|Burkholderiaceae 28216|Betaproteobacteria EH Belongs to the TPP enzyme family xsc - 2.3.3.15 ko:K03852 ko00430,map00430 - R05651 RC02903,RC02909 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_533026_1 927677.ALVU02000001_gene1806 1.18e-42 145.0 COG5485@1|root,COG5485@2|Bacteria,1GCKP@1117|Cyanobacteria 1117|Cyanobacteria S Ester cyclase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - SnoaL k59_950567_1 273063.STK_23690 4.21e-18 88.6 COG0247@1|root,arCOG00343@2157|Archaea 2157|Archaea C Cysteine-rich domain - - 1.1.5.3 ko:K00113 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - CCG k59_481761_1 1211114.ALIP01000127_gene593 1.56e-51 169.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1X304@135614|Xanthomonadales 135614|Xanthomonadales J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_481761_2 1123368.AUIS01000013_gene875 6.28e-72 218.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,1S201@1236|Gammaproteobacteria,2NCUZ@225057|Acidithiobacillales 225057|Acidithiobacillales J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_1630495_1 331678.Cphamn1_0839 2.02e-84 276.0 COG1132@1|root,COG1132@2|Bacteria,1FDCF@1090|Chlorobi 1090|Chlorobi V PFAM ABC transporter transmembrane region - - - ko:K06147,ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_640725_1 56780.SYN_02762 2.94e-54 187.0 COG1624@1|root,COG4856@1|root,COG1624@2|Bacteria,COG4856@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA - - - - - - - - - - - DisA_N,YbbR k59_1002890_1 870187.Thini_2252 5.64e-78 245.0 COG0312@1|root,COG0312@2|Bacteria,1QM7I@1224|Proteobacteria,1RSF3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Zn-dependent tldE2 - - - - - - - - - - - PmbA_TldD k59_1421904_1 1121920.AUAU01000012_gene2678 1.79e-69 237.0 COG1331@1|root,COG1331@2|Bacteria,3Y3AA@57723|Acidobacteria 57723|Acidobacteria O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_481781_1 1235457.C404_16360 7.5e-19 86.7 COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2VQ2S@28216|Betaproteobacteria,1K32J@119060|Burkholderiaceae 28216|Betaproteobacteria S Smr protein MutS2 smrA - - - - - - - - - - - Smr k59_1369009_2 688245.CtCNB1_0900 1.08e-53 171.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,2VR2S@28216|Betaproteobacteria,4ADW5@80864|Comamonadaceae 28216|Betaproteobacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_1475525_1 1123487.KB892835_gene3567 2.09e-15 82.4 COG3866@1|root,COG3866@2|Bacteria,1MUT3@1224|Proteobacteria 1224|Proteobacteria G Pectate lyase - - 4.2.2.2 ko:K01728 ko00040,ko02024,map00040,map02024 - R02361,R06240 RC00049,RC00705 ko00000,ko00001,ko01000 - - - Pec_lyase_C k59_1369022_1 314278.NB231_00440 1.06e-21 91.3 COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1WX63@135613|Chromatiales 135613|Chromatiales S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_1369022_2 1244869.H261_09252 8.76e-29 115.0 COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,1MXK5@1224|Proteobacteria,2U13I@28211|Alphaproteobacteria,2JQVM@204441|Rhodospirillales 204441|Rhodospirillales S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - AMMECR1,Memo k59_1108094_1 436308.Nmar_0223 2.11e-109 322.0 COG0788@1|root,arCOG02826@2157|Archaea,41S78@651137|Thaumarchaeota 651137|Thaumarchaeota F Formyl transferase - - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT_6,Formyl_trans_N k59_481805_1 472759.Nhal_0146 8.08e-146 426.0 COG0388@1|root,COG0454@1|root,COG0388@2|Bacteria,COG0456@2|Bacteria,1MX4I@1224|Proteobacteria,1RP30@1236|Gammaproteobacteria,1WW4Z@135613|Chromatiales 135613|Chromatiales K Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - - - - - - - - - - Acetyltransf_1,CN_hydrolase k59_797795_1 1283300.ATXB01000002_gene2886 6.27e-29 119.0 COG3637@1|root,COG3637@2|Bacteria,1R42W@1224|Proteobacteria,1RYPE@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Putative outer membrane beta-barrel porin, MtrB/PioB - - - - - - - - - - - - MtrB_PioB k59_1316250_1 339670.Bamb_5834 7.4e-12 67.4 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,1JZT2@119060|Burkholderiaceae 28216|Betaproteobacteria T adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,TPR_4,zinc_ribbon_2 k59_1316250_2 1443111.JASG01000004_gene3633 1.91e-14 73.6 COG0738@1|root,COG0738@2|Bacteria,1QVNU@1224|Proteobacteria,2UMIH@28211|Alphaproteobacteria,3ZVC6@60136|Sulfitobacter 28211|Alphaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1267499_1 225937.HP15_2796 5.97e-08 53.5 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,4641H@72275|Alteromonadaceae 1236|Gammaproteobacteria S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_950608_1 521096.Tpau_1654 8.24e-13 70.5 COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria 201174|Actinobacteria L Belongs to the 'phage' integrase family. XerC subfamily xerC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_950608_2 1423743.JCM14108_229 2.87e-06 48.5 COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,4HINN@91061|Bacilli,3F6GK@33958|Lactobacillaceae 91061|Bacilli J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_1630532_1 653733.Selin_2431 6.06e-134 389.0 COG0016@1|root,COG0016@2|Bacteria 2|Bacteria J phenylalanine-tRNA ligase activity pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF987.Gmet_1415 Phe_tRNA-synt_N,tRNA-synt_2d k59_1267501_1 396588.Tgr7_1432 1.63e-97 289.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1WW3F@135613|Chromatiales 135613|Chromatiales S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_1267501_2 629265.PMA4326_11797 1.64e-08 54.7 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1Z4WP@136849|Pseudomonas syringae group 1236|Gammaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0030091,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_1421940_1 1042377.AFPJ01000023_gene657 3.35e-66 231.0 COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria 1224|Proteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - SdrD_B k59_846738_1 1380394.JADL01000014_gene204 1.03e-85 265.0 COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2TR37@28211|Alphaproteobacteria,2JQ09@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the LDH2 MDH2 oxidoreductase family - - 1.1.1.338 ko:K16844 ko00270,ko01120,map00270,map01120 - R07137 RC00031 ko00000,ko00001,ko01000 - - - Ldh_2 k59_846738_2 1499680.CCFE01000021_gene2183 7.77e-13 70.9 COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,4H9QK@91061|Bacilli,1ZDI2@1386|Bacillus 91061|Bacilli H Aminotransferase class-III - - - - - - - - - - - - Aminotran_3 k59_1002920_2 429009.Adeg_1731 4.94e-05 47.0 COG1806@1|root,COG1806@2|Bacteria,1TPG0@1239|Firmicutes,249ID@186801|Clostridia,42EYU@68295|Thermoanaerobacterales 186801|Clostridia F Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation yqfL - 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_1630541_2 118161.KB235922_gene3387 3.3e-12 67.0 COG1215@1|root,COG1215@2|Bacteria,1GQT8@1117|Cyanobacteria 1117|Cyanobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1421950_1 1123073.KB899245_gene95 8.79e-106 328.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1X4EZ@135614|Xanthomonadales 135614|Xanthomonadales L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_114749_1 414684.RC1_0409 3.05e-23 100.0 COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,2U55H@28211|Alphaproteobacteria 28211|Alphaproteobacteria F P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_114749_2 756272.Plabr_1535 1.4e-20 90.1 COG0176@1|root,COG0176@2|Bacteria,2IY2M@203682|Planctomycetes 203682|Planctomycetes H Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k59_640801_1 1304275.C41B8_01310 1.27e-30 114.0 COG0801@1|root,COG0801@2|Bacteria,1RHNN@1224|Proteobacteria,1S62M@1236|Gammaproteobacteria 1236|Gammaproteobacteria H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK2 - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK k59_640807_2 857290.HMPREF9156_01198 8.55e-21 92.0 COG0325@1|root,COG0325@2|Bacteria,2GMRJ@201174|Actinobacteria,4CZUY@85004|Bifidobacteriales 201174|Actinobacteria S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_1316276_2 1333998.M2A_2780 8.26e-59 196.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Flavoprotein involved in K transport - - 1.14.13.160,1.14.13.22,1.14.13.226 ko:K03379,ko:K18371,ko:K21730 ko00640,ko00930,ko01120,ko01220,map00640,map00930,map01120,map01220 - R02231,R06622,R10704 RC00662,RC01550,RC03250 ko00000,ko00001,ko01000 - - - FMO-like,Pyr_redox_2,Pyr_redox_3 k59_428934_1 1123368.AUIS01000010_gene2375 4.75e-118 353.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1S14K@1236|Gammaproteobacteria,2NBXM@225057|Acidithiobacillales 225057|Acidithiobacillales J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) - - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_165560_1 1523503.JPMY01000009_gene625 4.31e-51 178.0 COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria 1236|Gammaproteobacteria M N-acetylmuramoyl-L-alanine amidase amiC - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,LysM k59_66251_1 465541.ATCJ01000005_gene6038 2.4e-146 431.0 COG1960@1|root,COG1960@2|Bacteria,2GJHM@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase aidB - - ko:K09456 - - - - ko00000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_481854_1 1265503.KB905171_gene534 3.44e-29 117.0 2EY1D@1|root,33RAB@2|Bacteria,1R00N@1224|Proteobacteria,1SJMZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_533102_1 713586.KB900536_gene630 5.48e-151 431.0 COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,1RSNX@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives ylbG - - - - - - - - - - - HTH_29,rve,rve_2,rve_3 k59_950648_1 574966.KB898646_gene3094 5.73e-13 67.4 COG3116@1|root,COG3116@2|Bacteria,1NI3C@1224|Proteobacteria,1SGSB@1236|Gammaproteobacteria,1XMJC@135619|Oceanospirillales 135619|Oceanospirillales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsL - - ko:K03586 - - - - ko00000,ko03036 - - - FtsL k59_950648_2 765914.ThisiDRAFT_1099 2.21e-68 227.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1WWDS@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_66266_1 1150469.RSPPHO_01888 1.75e-73 249.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,2JPTT@204441|Rhodospirillales 204441|Rhodospirillales C COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1055902_1 1255043.TVNIR_0508 9.84e-50 172.0 COG2199@1|root,COG3706@2|Bacteria,1RCC4@1224|Proteobacteria,1S523@1236|Gammaproteobacteria 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_1475610_2 240016.ABIZ01000001_gene3779 2.77e-18 79.0 COG0228@1|root,COG0228@2|Bacteria,46WC2@74201|Verrucomicrobia,2IUP4@203494|Verrucomicrobiae 203494|Verrucomicrobiae J Ribosomal protein S16 - - - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_1578337_1 522306.CAP2UW1_3901 8.98e-07 51.2 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2VK1S@28216|Betaproteobacteria,1KQUV@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria U FecCD transport family btuC - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_1578337_2 396588.Tgr7_2416 2.11e-35 126.0 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1WXJF@135613|Chromatiales 135613|Chromatiales E HAD-superfamily subfamily IB hydrolase, TIGR01490 - - - - - - - - - - - - HAD k59_641870_1 72664.XP_006412796.1 2.67e-06 53.1 COG4638@1|root,2QQJW@2759|Eukaryota,37M74@33090|Viridiplantae,3GARM@35493|Streptophyta,3HWXV@3699|Brassicales 35493|Streptophyta P choline monooxygenase - - 1.14.15.7 ko:K00499 ko00260,map00260 - R07409 RC00087 ko00000,ko00001,ko01000 - - - Rieske,Ring_hydroxyl_A k59_67310_1 228410.NE0361 8.24e-157 468.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,371SW@32003|Nitrosomonadales 28216|Betaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_67310_2 944435.AXAJ01000004_gene2193 8.32e-24 102.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,1K1V8@119060|Burkholderiaceae 28216|Betaproteobacteria C Dehydrogenase pdhL - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_1160239_1 880073.Calab_3321 0.0 960.0 COG3696@1|root,COG3696@2|Bacteria,2NNKZ@2323|unclassified Bacteria 2|Bacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K07787,ko:K15726 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_1160239_2 941449.dsx2_0364 1.37e-110 342.0 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2M9X5@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - DUF3347,HlyD_D23 k59_742844_1 690850.Desaf_2672 5.78e-21 96.3 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2M9X5@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - DUF3347,HlyD_D23 k59_742844_2 247490.KSU1_C1671 4.29e-46 169.0 COG1538@1|root,COG1538@2|Bacteria,2IZPU@203682|Planctomycetes 203682|Planctomycetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_273139_2 748658.KB907318_gene970 6.17e-06 52.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1WX1Z@135613|Chromatiales 135613|Chromatiales EQ Hydantoinase B/oxoprolinase - - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_700422_1 521674.Plim_0955 1.42e-42 156.0 COG0733@1|root,COG0733@2|Bacteria,2J29X@203682|Planctomycetes 203682|Planctomycetes S Sodium:neurotransmitter symporter family - - - - - - - - - - - - SNF k59_1166163_1 439235.Dalk_0106 1.98e-46 165.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42YAX@68525|delta/epsilon subdivisions,2WU3C@28221|Deltaproteobacteria,2MMI7@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_541323_1 1384054.N790_11390 4.28e-21 93.6 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,1X5AZ@135614|Xanthomonadales 135614|Xanthomonadales S MMPL family - - - - - - - - - - - - MMPL k59_541323_2 748247.AZKH_1943 9.75e-05 48.1 COG4447@1|root,COG4447@2|Bacteria,1R84R@1224|Proteobacteria,2VMQ1@28216|Betaproteobacteria,2KXPY@206389|Rhodocyclales 28216|Betaproteobacteria S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - PSII_BNR k59_809121_1 566466.NOR53_2707 2.84e-15 77.0 2E5SP@1|root,330H2@2|Bacteria,1NDBY@1224|Proteobacteria 1224|Proteobacteria S YMGG-like Gly-zipper - - - - - - - - - - - - Gly-zipper_OmpA,Gly-zipper_YMGG k59_1486718_1 90814.KL370892_gene2162 7.53e-47 170.0 COG3250@1|root,COG3250@2|Bacteria 2|Bacteria G beta-galactosidase activity - - 3.2.1.89 ko:K01224 - - - - ko00000,ko01000 - - - Big_4,F5_F8_type_C,Glyco_hydro_2_C,Glyco_hydro_53 k59_1278991_1 95619.PM1_0226320 1.46e-44 159.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Membrane-bound serine protease (ClpP class) nfeD - - ko:K07403 - - - - ko00000 - - - NfeD k59_1278991_2 472759.Nhal_1053 2.95e-16 78.2 COG1893@1|root,COG1893@2|Bacteria,1R60C@1224|Proteobacteria,1RZQZ@1236|Gammaproteobacteria,1WXZX@135613|Chromatiales 135613|Chromatiales H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - - - - - - - - - - - k59_1278991_3 323261.Noc_1927 4.27e-31 116.0 COG1893@1|root,COG1893@2|Bacteria,1R60C@1224|Proteobacteria,1RZQZ@1236|Gammaproteobacteria,1WXZX@135613|Chromatiales 135613|Chromatiales H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - - - - - - - - - - - k59_387924_1 1089552.KI911559_gene196 7.02e-21 84.3 2E7PS@1|root,3325B@2|Bacteria,1N7R7@1224|Proteobacteria,2UFCM@28211|Alphaproteobacteria,2JUVZ@204441|Rhodospirillales 204441|Rhodospirillales S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - k59_387924_2 443143.GM18_1530 3.63e-15 76.6 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_8,Response_reg k59_809130_1 237368.SCABRO_01842 3.74e-43 149.0 COG1047@1|root,COG1047@2|Bacteria,2J1AR@203682|Planctomycetes 203682|Planctomycetes O FKBP-type peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - FKBP_C k59_1528009_1 1449080.JQMV01000003_gene1795 5.5e-33 133.0 COG0446@1|root,COG0446@2|Bacteria,1WIKH@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Flavocytochrome c sulphide dehydrogenase, flavin-binding - - - - - - - - - - - - FCSD-flav_bind,Pyr_redox_2,TAT_signal k59_493156_1 519989.ECTPHS_10276 2.62e-62 208.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1WWEZ@135613|Chromatiales 135613|Chromatiales H Catalyzes the oxidation of L-aspartate to iminoaspartate - - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1322533_1 1229909.NSED_06310 2.71e-92 275.0 COG1407@1|root,arCOG01150@2157|Archaea,41SJB@651137|Thaumarchaeota 651137|Thaumarchaeota S Calcineurin-like phosphoesterase - - - ko:K06953 - - - - ko00000 - - - Metallophos k59_1279007_1 56780.SYN_00608 7.75e-73 236.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria,2MQ6I@213462|Syntrophobacterales 28221|Deltaproteobacteria E PFAM Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035,ko:K13893 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 k59_387938_1 414684.RC1_2604 3.95e-14 82.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,2JPMW@204441|Rhodospirillales 204441|Rhodospirillales L Belongs to the helicase family. UvrD subfamily addA - 3.6.4.12 ko:K16898 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_438182_1 307480.IW16_22800 9.23e-24 101.0 COG1524@1|root,COG1524@2|Bacteria,4NFFG@976|Bacteroidetes,1HX3P@117743|Flavobacteriia,3ZR7U@59732|Chryseobacterium 976|Bacteroidetes S phosphodiesterase - - 3.1.3.1 ko:K01113 ko00790,ko01100,ko02020,map00790,map01100,map02020 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phosphodiest k59_1116530_2 1454004.AW11_00495 5.32e-80 248.0 COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2VH6H@28216|Betaproteobacteria 28216|Betaproteobacteria G Glucose sorbosone yliI - - ko:K21430 - - - - ko00000,ko01000 - - - GSDH k59_855428_2 1150864.MILUP08_44438 2.17e-39 140.0 COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4D9ND@85008|Micromonosporales 201174|Actinobacteria V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1279010_1 870187.Thini_0124 4.36e-35 140.0 COG0823@1|root,COG2304@1|root,COG2931@1|root,COG3210@1|root,COG3420@1|root,COG4932@1|root,COG4935@1|root,COG0823@2|Bacteria,COG2304@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3420@2|Bacteria,COG4932@2|Bacteria,COG4935@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family cglB - - ko:K12287,ko:K12516,ko:K20276 ko02024,map02024 - - - ko00000,ko00001,ko02000,ko02044 1.B.12.5.5 - - Beta_helix,DUF3494,HemolysinCabind k59_1322536_2 316067.Geob_0367 3.53e-14 75.1 COG2909@1|root,COG4783@1|root,COG2909@2|Bacteria,COG4783@2|Bacteria,1QYWH@1224|Proteobacteria 1224|Proteobacteria K Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3,TPR_16,TPR_19 k59_1279017_1 436308.Nmar_0651 1.45e-67 230.0 COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota 651137|Thaumarchaeota D SMC proteins Flexible Hinge Domain - - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_281037_1 177439.DP1677 2.65e-65 213.0 COG1916@1|root,COG1916@2|Bacteria,1MWJ0@1224|Proteobacteria,42P2H@68525|delta/epsilon subdivisions,2WJQM@28221|Deltaproteobacteria,2MI76@213118|Desulfobacterales 28221|Deltaproteobacteria S TIGRFAM TraB family protein - - - - - - - - - - - - TraB k59_652047_1 1238182.C882_2761 4.26e-72 235.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TQJR@28211|Alphaproteobacteria,2JQA5@204441|Rhodospirillales 204441|Rhodospirillales I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases - - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_77399_1 697282.Mettu_3086 7.85e-75 239.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,1XED7@135618|Methylococcales 135618|Methylococcales HJ PFAM ATP-grasp fold - - - - - - - - - - - - RLAN,RimK k59_1528015_1 436308.Nmar_0641 2.21e-49 166.0 arCOG08669@1|root,arCOG08669@2157|Archaea,41SEB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1528015_2 436308.Nmar_0642 4.48e-37 135.0 COG0389@1|root,arCOG04582@2157|Archaea,41SDV@651137|Thaumarchaeota 651137|Thaumarchaeota L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis dbh - 2.7.7.7 ko:K04479 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_1279021_3 314230.DSM3645_04355 4.22e-22 95.9 COG1013@1|root,COG1013@2|Bacteria,2IY6Z@203682|Planctomycetes 203682|Planctomycetes C COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_281041_2 1123376.AUIU01000016_gene315 1.1e-53 179.0 COG2876@1|root,COG2876@2|Bacteria,3J0A5@40117|Nitrospirae 40117|Nitrospirae E NeuB family - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_958897_1 379066.GAU_0752 3.76e-11 60.1 296V5@1|root,2ZU41@2|Bacteria,1ZU78@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - k59_958897_2 163908.KB235896_gene253 7.02e-06 49.3 COG0665@1|root,COG2022@1|root,COG0665@2|Bacteria,COG2022@2|Bacteria,1FZYU@1117|Cyanobacteria,1HJNB@1161|Nostocales 1117|Cyanobacteria H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - DAO,ThiG k59_1433066_1 431947.PGN_1821 3.1e-09 66.6 COG3209@1|root,COG3209@2|Bacteria,4NGJF@976|Bacteroidetes,2FQPQ@200643|Bacteroidia 976|Bacteroidetes M RHS repeat-associated core domain protein - - - - - - - - - - - - RHS_repeat,SpvB,VCBS k59_1528022_1 768671.ThimaDRAFT_2884 1.72e-35 138.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1WXN6@135613|Chromatiales 135613|Chromatiales J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1279034_1 999141.GME_03602 8.68e-27 108.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1XIJG@135619|Oceanospirillales 135619|Oceanospirillales M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_1279034_2 997346.HMPREF9374_2249 3.1e-53 184.0 COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,4H9XK@91061|Bacilli,27B6V@186824|Thermoactinomycetaceae 91061|Bacilli E Histidinol dehydrogenase hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU34910 Histidinol_dh k59_959842_1 1121937.AUHJ01000010_gene1707 1.45e-137 402.0 COG2159@1|root,COG2159@2|Bacteria,1PZ2I@1224|Proteobacteria,1S1Y9@1236|Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase of the TIM-barrel fold - - - - - - - - - - - - Amidohydro_2 k59_282082_1 323848.Nmul_A0957 4.06e-12 65.9 COG1562@1|root,COG1562@2|Bacteria,1R4ZD@1224|Proteobacteria,2VQQ2@28216|Betaproteobacteria,374P4@32003|Nitrosomonadales 28216|Betaproteobacteria I Squalene/phytoene synthase - - 2.5.1.21 ko:K00801 ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130 - R00702,R02872,R06223 RC00362,RC00796,RC02839 ko00000,ko00001,ko01000,ko01006 - - - SQS_PSY k59_1167000_1 515635.Dtur_0226 1.74e-14 79.7 COG0834@1|root,COG2203@1|root,COG3437@1|root,COG0834@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria 2|Bacteria T response regulator, receiver - - 2.7.13.3 ko:K02030,ko:K13040 ko02020,map02020 M00236,M00514 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022 3.A.1.3 - - EAL,GAF_2,GGDEF,HATPase_c,HD,HD_5,HisKA,PAS_3,PAS_9,Response_reg,SBP_bac_3 k59_959855_1 1206744.BAGL01000087_gene2770 2.2e-17 84.0 COG0177@1|root,COG0177@2|Bacteria,2GNYB@201174|Actinobacteria,4FVJU@85025|Nocardiaceae 201174|Actinobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate - - - - - - - - - - - - - k59_1378257_1 557599.MKAN_07660 3.42e-20 89.7 2FBIE@1|root,343PQ@2|Bacteria,2GP5F@201174|Actinobacteria,236ND@1762|Mycobacteriaceae 201174|Actinobacteria S Spirocyclase AveC-like - - - - - - - - - - - - AveC_like k59_1378257_2 1122247.C731_4543 1.15e-97 290.0 COG0714@1|root,COG0714@2|Bacteria,2GWNF@201174|Actinobacteria,232BM@1762|Mycobacteriaceae 201174|Actinobacteria S CbbQ NirQ NorQ C-terminal - - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5,CbbQ_C k59_1280734_2 797304.Natgr_0349 1.71e-46 159.0 COG1117@1|root,arCOG00231@2157|Archaea,2XTJK@28890|Euryarchaeota,23SS7@183963|Halobacteria 183963|Halobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB1 - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_1167006_1 1282876.BAOK01000001_gene3321 4.28e-66 220.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_908904_1 278963.ATWD01000001_gene2820 7.08e-59 195.0 COG0156@1|root,COG0156@2|Bacteria,3Y3J2@57723|Acidobacteria,2JI0H@204432|Acidobacteriia 204432|Acidobacteriia E Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide - - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1488348_1 1229909.NSED_02380 3.72e-16 75.9 COG0640@1|root,arCOG01686@2157|Archaea 2157|Archaea K regulatory protein, arsR - - - - - - - - - - - - HTH_20 k59_1488348_2 436308.Nmar_0471 9.37e-14 71.6 COG1948@1|root,arCOG02284@2157|Archaea,41T0R@651137|Thaumarchaeota 651137|Thaumarchaeota L Beta propeller domain - - - - - - - - - - - - Beta_propel k59_751600_1 2340.JV46_05390 2.63e-85 269.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria,1JATD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Na+/Pi-cotransporter yjbB GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0035435,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_334547_1 1170562.Cal6303_3779 1.68e-45 152.0 COG0757@1|root,COG0757@2|Bacteria,1G5X4@1117|Cyanobacteria,1HN4S@1161|Nostocales 1117|Cyanobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_1434634_1 545276.KB898732_gene2457 4.65e-62 208.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1WWYZ@135613|Chromatiales 135613|Chromatiales E PFAM Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_542354_1 1232410.KI421426_gene1381 8.14e-149 433.0 COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,42QA4@68525|delta/epsilon subdivisions,2WKD1@28221|Deltaproteobacteria,43SDE@69541|Desulfuromonadales 28221|Deltaproteobacteria S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139,DUF4140 k59_1065699_1 1297863.APJF01000010_gene3415 1.41e-20 89.4 COG0346@1|root,COG0346@2|Bacteria,1R9XW@1224|Proteobacteria,2U6IT@28211|Alphaproteobacteria,3K3B6@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E lactoylglutathione lyase activity - - - - - - - - - - - - Glyoxalase_4 k59_1065699_2 293826.Amet_4266 2.69e-44 146.0 COG2154@1|root,COG2154@2|Bacteria,1VERE@1239|Firmicutes,24NE1@186801|Clostridia,36SAJ@31979|Clostridiaceae 186801|Clostridia H Pterin 4 alpha carbinolamine dehydratase - - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a k59_653719_1 497964.CfE428DRAFT_2705 2.8e-23 100.0 COG0845@1|root,COG0845@2|Bacteria,46SVD@74201|Verrucomicrobia 74201|Verrucomicrobia M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cusB - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - DUF3347,HlyD_D23 k59_653719_2 314278.NB231_16563 1.24e-25 106.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1X0CA@135613|Chromatiales 135613|Chromatiales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_126367_1 551275.KB899544_gene916 1.56e-81 264.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TWVC@28211|Alphaproteobacteria,440R8@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Sterol-sensing domain of SREBP cleavage-activation - - - ko:K07003 - - - - ko00000 - - - MMPL k59_908940_1 1232410.KI421421_gene3663 4.46e-31 125.0 COG1192@1|root,COG1192@2|Bacteria,1NPCB@1224|Proteobacteria,42Y7J@68525|delta/epsilon subdivisions,2WUHN@28221|Deltaproteobacteria,43T7Q@69541|Desulfuromonadales 28221|Deltaproteobacteria D NUBPL iron-transfer P-loop NTPase - - - - - - - - - - - - AAA_31 k59_1488385_2 1123242.JH636434_gene4996 3.47e-86 261.0 COG1432@1|root,COG1432@2|Bacteria,2IY4C@203682|Planctomycetes 203682|Planctomycetes S OST-HTH/LOTUS domain - - - - - - - - - - - - NYN,OST-HTH k59_1323424_1 1123355.JHYO01000018_gene1661 2.9e-41 143.0 COG1633@1|root,COG1633@2|Bacteria,1RJFW@1224|Proteobacteria,2U6JY@28211|Alphaproteobacteria,36Z1C@31993|Methylocystaceae 28211|Alphaproteobacteria S Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_126380_1 396588.Tgr7_1280 2.76e-24 107.0 COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria 1224|Proteobacteria L double-strand break repair protein AddB addB - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1 k59_653745_1 1333998.M2A_1692 5.86e-56 188.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,4BPWX@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_810864_2 1499680.CCFE01000021_gene1902 3.94e-21 92.4 COG0680@1|root,COG0680@2|Bacteria,1V7KQ@1239|Firmicutes,4HHA5@91061|Bacilli,1ZGIB@1386|Bacillus 91061|Bacilli C COG0680 Ni,Fe-hydrogenase maturation factor - - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI k59_1488400_1 1123072.AUDH01000004_gene726 1.17e-105 313.0 COG1028@1|root,COG1028@2|Bacteria,1MWGC@1224|Proteobacteria,2TSNX@28211|Alphaproteobacteria,2JRKC@204441|Rhodospirillales 204441|Rhodospirillales IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_439214_1 1121912.AUHD01000010_gene3603 2.48e-09 63.5 COG2519@1|root,COG2519@2|Bacteria,4PPF5@976|Bacteroidetes,1I286@117743|Flavobacteriia 976|Bacteroidetes J Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21 k59_282157_1 744980.TRICHSKD4_5223 9.33e-09 58.2 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRIH@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family caiD - 4.2.1.149 ko:K08299 - - R10675 RC01095 ko00000,ko01000 - - - ECH_1 k59_282157_2 1123321.KB905813_gene1523 2.14e-43 153.0 COG1960@1|root,COG1960@2|Bacteria,2ID1K@201174|Actinobacteria 201174|Actinobacteria I Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_1378326_1 292415.Tbd_2548 2.48e-11 70.9 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,1KS45@119069|Hydrogenophilales 119069|Hydrogenophilales T Signal transducing histidine kinase, homodimeric domain - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,HATPase_c,Hpt,Response_reg k59_1065735_1 566466.NOR53_3505 5.8e-87 271.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPM3@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - Sulfatase k59_709320_2 344747.PM8797T_28484 3e-23 99.8 COG1244@1|root,COG1244@2|Bacteria,2IX1W@203682|Planctomycetes 203682|Planctomycetes S Elongator protein 3, MiaB family, Radical SAM - - - ko:K06936 - - - - ko00000 - - - - k59_1535622_2 1232410.KI421425_gene1548 2.75e-20 90.1 COG0457@1|root,COG0457@2|Bacteria,1N1J2@1224|Proteobacteria,42ZHG@68525|delta/epsilon subdivisions,2WV2W@28221|Deltaproteobacteria,43UR6@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1126647_1 1116472.MGMO_54c00190 4.19e-46 160.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1XEGW@135618|Methylococcales 135618|Methylococcales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_136114_1 287.DR97_2951 3.4e-63 206.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1YDYY@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_1020614_1 748280.NH8B_2855 2.17e-93 291.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,2KPZF@206351|Neisseriales 206351|Neisseriales IQ AMP-binding enzyme fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_759412_2 1219031.BBJR01000001_gene505 2.22e-44 155.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,4AB6A@80864|Comamonadaceae 28216|Betaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1535643_1 1120953.AUBH01000011_gene441 6.32e-05 47.4 COG0834@1|root,COG0834@2|Bacteria,1NG12@1224|Proteobacteria,1SZIM@1236|Gammaproteobacteria,46CYS@72275|Alteromonadaceae 1236|Gammaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_821690_1 1484157.PSNIH2_17710 8.17e-15 77.4 COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,1RV34@1236|Gammaproteobacteria,3VYBD@53335|Pantoea 1236|Gammaproteobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_3 k59_505716_2 160492.XF_0685 1.92e-64 204.0 28J2E@1|root,2Z8YX@2|Bacteria,1REPW@1224|Proteobacteria,1S4IX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2815) - - - - - - - - - - - - DUF2815 k59_1499157_1 287.DR97_2795 8.63e-17 84.7 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,1RQKR@1236|Gammaproteobacteria,1YFJP@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Belongs to the GcvT family soxA - 1.5.3.1 ko:K00302 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2 k59_1330244_1 105559.Nwat_1650 1.05e-58 205.0 COG0265@1|root,COG0308@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1SYTD@1236|Gammaproteobacteria,1X2IM@135613|Chromatiales 135613|Chromatiales EO Peptidase family M28 - - - - - - - - - - - - PDZ_2,Peptidase_M1,Peptidase_M28 k59_1074559_2 3659.XP_004153645.1 2.11e-24 101.0 COG0466@1|root,KOG2004@2759|Eukaryota,37QRW@33090|Viridiplantae,3GCYG@35493|Streptophyta,4JJKB@91835|fabids 35493|Streptophyta O ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import - - - - - - - - - - - - AAA,LON_substr_bdg,Lon_C k59_136153_1 330214.NIDE1872 2.02e-70 218.0 COG0127@1|root,COG0127@2|Bacteria,3J0ST@40117|Nitrospirae 40117|Nitrospirae F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like k59_1330245_1 944481.JAFP01000001_gene796 5.28e-31 126.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2M6JX@213113|Desulfurellales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_89628_1 357804.Ping_1111 7.13e-30 128.0 COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - EAL,GGDEF,PAS_3,PAS_4,PAS_9,Reg_prop,Y_Y_Y k59_291120_1 404589.Anae109_1281 3.39e-16 81.6 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2YWE3@29|Myxococcales 28221|Deltaproteobacteria CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein nuoL-1 - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_291120_2 649743.HMPREF0972_00980 1.35e-11 61.2 COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria,4D66I@85005|Actinomycetales 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00340,ko:K05576 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_1654122_1 1131266.ARWQ01000002_gene468 1.57e-147 429.0 COG0129@1|root,arCOG04045@2157|Archaea,41SD0@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_14295_1 1232410.KI421423_gene1932 1.22e-34 136.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,439YP@68525|delta/epsilon subdivisions,2X28D@28221|Deltaproteobacteria,43TFE@69541|Desulfuromonadales 28221|Deltaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_666385_2 1380394.JADL01000003_gene5040 6.62e-72 228.0 COG1024@1|root,COG1024@2|Bacteria,1PU1Q@1224|Proteobacteria,2TSW6@28211|Alphaproteobacteria,2JS2P@204441|Rhodospirillales 204441|Rhodospirillales I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_1654139_1 330214.NIDE3860 3.29e-58 189.0 COG1926@1|root,COG1926@2|Bacteria,3J18T@40117|Nitrospirae 40117|Nitrospirae S Phosphoribosyl transferase domain - - - - - - - - - - - - Pribosyltran k59_1128456_1 297246.lpp0727 7.7e-30 124.0 COG1252@1|root,COG2259@1|root,COG1252@2|Bacteria,COG2259@2|Bacteria,1MX96@1224|Proteobacteria,1RM9I@1236|Gammaproteobacteria,1JCYU@118969|Legionellales 118969|Legionellales C Pyridine nucleotide-disulphide oxidoreductase ndh - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - DoxX,Pyr_redox_2 k59_1175073_2 1122164.JHWF01000001_gene2013 1.49e-32 124.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,1JCXF@118969|Legionellales 118969|Legionellales S Serine aminopeptidase, S33 - - - ko:K07019 - - - - ko00000 - - - Abhydrolase_1 k59_14300_1 1279017.AQYJ01000026_gene58 5.92e-39 148.0 COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,1SEWA@1236|Gammaproteobacteria,469S7@72275|Alteromonadaceae 1236|Gammaproteobacteria M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11,SdrD_B k59_666410_1 519989.ECTPHS_12515 1.68e-66 221.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales 135613|Chromatiales I PFAM AMP-dependent synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_865698_1 861299.J421_1368 8.7e-54 183.0 COG0312@1|root,COG0312@2|Bacteria,1ZSYW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative modulator of DNA gyrase - - - - - - - - - - - - PmbA_TldD k59_238618_2 330214.NIDE4070 2.81e-117 338.0 COG0560@1|root,COG0560@2|Bacteria 2|Bacteria E Phosphoserine phosphatase thrH - 2.7.1.39,3.1.3.3 ko:K02203 ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230 M00018 R00582,R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD,Hydrolase k59_760603_1 641107.CDLVIII_1025 6.07e-51 181.0 COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,36DY8@31979|Clostridiaceae 186801|Clostridia C aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - 1.17.1.5 ko:K20447 ko00760,ko01120,map00760,map01120 - R01720 RC00589 ko00000,ko00001,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1654190_1 768671.ThimaDRAFT_2365 2.44e-13 69.7 29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,1SBT1@1236|Gammaproteobacteria,1WYAZ@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4390) - - - - - - - - - - - - DUF4390 k59_1654190_2 265072.Mfla_0182 4.51e-09 60.1 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria,2KKR4@206350|Nitrosomonadales 206350|Nitrosomonadales T histidine kinase HAMP region domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_7 k59_91458_1 1123376.AUIU01000015_gene487 9.15e-32 125.0 COG0612@1|root,COG0612@2|Bacteria,3J0BY@40117|Nitrospirae 40117|Nitrospirae S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1293403_1 1469245.JFBG01000019_gene1130 7.09e-38 139.0 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales 135613|Chromatiales P Belongs to the sulfate adenylyltransferase family sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_969316_1 331869.BAL199_17763 6.31e-38 142.0 COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,2TTGI@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Major facilitator Superfamily aas - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_1076317_1 1122139.KB907862_gene612 3.84e-59 196.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1XI4U@135619|Oceanospirillales 135619|Oceanospirillales L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_1128506_1 1038859.AXAU01000028_gene25 2.73e-63 204.0 COG4177@1|root,COG4177@2|Bacteria,1N5I8@1224|Proteobacteria,2U0PT@28211|Alphaproteobacteria,3JSC7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1021869_1 221288.JH992901_gene4325 5.22e-68 226.0 COG1132@1|root,COG1132@2|Bacteria,1G1JY@1117|Cyanobacteria,1JJ9N@1189|Stigonemataceae 1117|Cyanobacteria V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_823573_1 768671.ThimaDRAFT_0215 2.93e-75 243.0 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,1S28B@1236|Gammaproteobacteria 1236|Gammaproteobacteria L nucleotidyltransferase DNA polymerase involved in DNA repair imuB - - ko:K14161 - - - - ko00000,ko03400 - - - IMS k59_396889_1 232721.Ajs_2156 2.32e-89 276.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2VP71@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM transposase, mutator type - - - - - - - - - - - - Transposase_mut k59_1293438_1 1190606.AJYG01000083_gene3196 8.35e-74 238.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,1RN2U@1236|Gammaproteobacteria,1XUQZ@135623|Vibrionales 135623|Vibrionales C Cytochrome bd terminal oxidase subunit I - - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_137909_1 1123355.JHYO01000024_gene1816 6.01e-85 265.0 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,371CQ@31993|Methylocystaceae 28211|Alphaproteobacteria CP Proton-conducting membrane transporter nuoN2 - 1.6.5.3 ko:K00343,ko:K05568 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 - - Proton_antipo_M k59_1237085_1 1439940.BAY1663_03504 1.7e-35 130.0 COG0319@1|root,COG1702@1|root,COG0319@2|Bacteria,COG1702@2|Bacteria,1MZ67@1224|Proteobacteria,1S6BS@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_1237085_2 1005058.UMN179_00677 1.32e-23 98.6 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1Y7KR@135625|Pasteurellales 135625|Pasteurellales T Phosphate starvation-inducible protein PhoH ybeZ - - ko:K06217 - - - - ko00000 - - - PhoH k59_1175136_1 710686.Mycsm_04824 1.63e-10 62.4 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,232T9@1762|Mycobacteriaceae 201174|Actinobacteria Q cytochrome p450 cyp130 GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0020037,GO:0030312,GO:0044464,GO:0046906,GO:0048037,GO:0071944,GO:0097159,GO:1901363 - ko:K21119 - - - - ko00000,ko00199 - - - p450 k59_1076363_1 243090.RB1924 4.72e-20 94.7 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - k59_137918_1 330214.NIDE4242 1.03e-46 162.0 COG1160@1|root,COG1160@2|Bacteria,3J0G3@40117|Nitrospirae 40117|Nitrospirae S GTPase that plays an essential role in the late steps of ribosome biogenesis engA - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_137918_2 330214.NIDE4241 2.92e-48 159.0 COG0637@1|root,COG0637@2|Bacteria 2|Bacteria S phosphonoacetaldehyde hydrolase activity - - 3.1.3.5 ko:K20881 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase k59_1536755_2 189753.AXAS01000055_gene5700 1.12e-38 140.0 COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,2TSQA@28211|Alphaproteobacteria,3JT1R@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Pyridine nucleotide-disulphide oxidoreductase - - - ko:K07222 - - - - ko00000 - - - Pyr_redox_3 k59_919911_1 619693.HMPREF6745_2352 7.92e-44 158.0 COG3172@1|root,COG3172@2|Bacteria,4NEQF@976|Bacteroidetes,2FN8P@200643|Bacteroidia 976|Bacteroidetes H Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - DUF4301 k59_292869_2 575540.Isop_2277 3.96e-08 57.0 COG0223@1|root,COG0223@2|Bacteria,2IYU1@203682|Planctomycetes 203682|Planctomycetes J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_507599_2 713586.KB900536_gene2354 3.6e-59 195.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales 135613|Chromatiales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_1076375_1 748658.KB907312_gene1314 1.19e-26 108.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,1WWI0@135613|Chromatiales 135613|Chromatiales J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_14334_1 1121106.JQKB01000012_gene4623 1.41e-81 251.0 COG2084@1|root,COG2084@2|Bacteria,1RA7F@1224|Proteobacteria,2U2MR@28211|Alphaproteobacteria,2JQVZ@204441|Rhodospirillales 204441|Rhodospirillales I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - - - - - - - - - - NAD_binding_11,NAD_binding_2 k59_1128560_1 1437882.AZRU01000016_gene3280 2.24e-41 147.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1RNPS@1236|Gammaproteobacteria,1YET8@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M MlaA lipoprotein vacJ - - ko:K04754 - - - - ko00000 - - - MlaA k59_1654272_1 436308.Nmar_1199 4.29e-12 65.9 COG4257@1|root,arCOG03564@2157|Archaea,41SM7@651137|Thaumarchaeota 651137|Thaumarchaeota V antibiotic catabolic process - - - ko:K18235 - - - - ko00000,ko01000,ko01504 - - - - k59_1654272_2 1229909.NSED_06825 3.27e-70 223.0 COG0585@1|root,arCOG04252@2157|Archaea,41S7C@651137|Thaumarchaeota 651137|Thaumarchaeota J tRNA pseudouridine synthase - - 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_1536764_1 1049564.TevJSym_bh00320 1.14e-51 172.0 COG0583@1|root,COG0583@2|Bacteria,1MUWX@1224|Proteobacteria,1RYWC@1236|Gammaproteobacteria,1JB8E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_1536764_2 935836.JAEL01000140_gene636 1.86e-63 207.0 COG2224@1|root,COG2224@2|Bacteria,1TP1U@1239|Firmicutes,4HBBD@91061|Bacilli,1ZBPW@1386|Bacillus 91061|Bacilli C Isocitrate lyase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_238685_1 1229909.NSED_01715 1.87e-28 104.0 arCOG10523@1|root,arCOG10523@2157|Archaea,41SSZ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_238685_2 1229909.NSED_01720 3.54e-84 253.0 COG0727@1|root,arCOG02579@2157|Archaea,41SH8@651137|Thaumarchaeota 651137|Thaumarchaeota S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_137955_1 1347369.CCAD010000082_gene2700 4.5e-11 69.7 COG2304@1|root,COG2304@2|Bacteria,1V01Q@1239|Firmicutes,4HE4F@91061|Bacilli,1ZC9U@1386|Bacillus 91061|Bacilli S protein containing a von Willebrand factor type A (vWA) domain vWFA2 - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_760669_1 693977.Deipr_2610 5.38e-06 53.9 COG0725@1|root,COG0725@2|Bacteria 2|Bacteria P tungstate binding modA GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015098,GO:0015103,GO:0015318,GO:0015399,GO:0015405,GO:0015412,GO:0015689,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0030151,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0034220,GO:0040007,GO:0042597,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043169,GO:0043225,GO:0043492,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0098656,GO:0099133,GO:1901359 - ko:K02020,ko:K07114 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 1.A.13.2.2,1.A.13.2.3,3.A.1.8 - iAF987.Gmet_0512,iECO111_1330.ECO111_0773,iHN637.CLJU_RS12820,iJN678.modA,iPC815.YPO1145 SBP_bac_11 k59_1501018_1 1408254.T458_04930 2.66e-35 130.0 28K7U@1|root,2Z9VT@2|Bacteria,1VAFZ@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - k59_292901_1 1297570.MESS4_380019 6.59e-117 351.0 COG0747@1|root,COG0747@2|Bacteria,1MXQ4@1224|Proteobacteria,2TTIZ@28211|Alphaproteobacteria,43GY5@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E ABC-type dipeptide transport system periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1596405_1 449673.BACSTE_01160 1.19e-06 56.2 COG0463@1|root,COG0463@2|Bacteria,4NM7V@976|Bacteroidetes,2G0B3@200643|Bacteroidia 976|Bacteroidetes M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1138721_1 330214.NIDE0228 5.54e-100 309.0 COG1009@1|root,COG1009@2|Bacteria,3J0AN@40117|Nitrospirae 40117|Nitrospirae CP NADH-quinone oxidoreductase - - 1.6.5.3 ko:K00341,ko:K05568,ko:K12139 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_1138721_2 459495.SPLC1_S081870 3.76e-22 90.1 COG0713@1|root,COG0713@2|Bacteria,1G6KK@1117|Cyanobacteria,1HBH9@1150|Oscillatoriales 1117|Cyanobacteria C electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration ndhE GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K05576 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_q2 k59_1138727_1 237368.SCABRO_03764 1.51e-43 162.0 COG1033@1|root,COG1033@2|Bacteria,2IYET@203682|Planctomycetes 203682|Planctomycetes S of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_561151_1 1267535.KB906767_gene820 7.19e-88 266.0 COG0214@1|root,COG0214@2|Bacteria,3Y3ST@57723|Acidobacteria,2JKN5@204432|Acidobacteriia 204432|Acidobacteriia H Belongs to the PdxS SNZ family - - 4.3.3.6 ko:K06215 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SOR_SNZ k59_190704_1 634177.GLX_02850 2.48e-56 192.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,2JQAF@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_874804_1 706587.Desti_0542 8.02e-69 231.0 COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42NNC@68525|delta/epsilon subdivisions,2WKQW@28221|Deltaproteobacteria,2MQ7A@213462|Syntrophobacterales 28221|Deltaproteobacteria S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_248210_1 696281.Desru_0255 1.72e-96 300.0 COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,260CD@186807|Peptococcaceae 186801|Clostridia J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon,tRNA_bind k59_101943_1 330214.NIDE3321 4.68e-99 299.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_769686_1 64471.sync_0372 5.79e-19 86.7 COG0436@1|root,COG0436@2|Bacteria,1G0NC@1117|Cyanobacteria,1GYP3@1129|Synechococcus 1117|Cyanobacteria H Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate dapL - 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_769686_2 675635.Psed_6784 3.68e-105 323.0 COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria,4E04S@85010|Pseudonocardiales 201174|Actinobacteria C FAD linked oxidases, C-terminal domain - - 2.5.1.26 ko:K00803 ko00565,ko01100,ko04146,map00565,map01100,map04146 - R04311 RC00020,RC02886 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_460664_1 292415.Tbd_1072 5.68e-69 229.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VS7B@28216|Betaproteobacteria 28216|Betaproteobacteria Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase_2 k59_874840_1 204669.Acid345_1270 2.93e-75 243.0 COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia 204432|Acidobacteriia Q Flavin containing amine oxidoreductase - - - - - - - - - - - - NAD_binding_8 k59_101975_1 1089548.KI783301_gene1343 1.57e-34 131.0 COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,3WE00@539002|Bacillales incertae sedis 91061|Bacilli IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1453703_1 330214.NIDE2461 1.24e-59 194.0 COG1561@1|root,COG1561@2|Bacteria,3J0QJ@40117|Nitrospirae 40117|Nitrospirae S Domain of unknown function (DUF1732) - - - - - - - - - - - - DUF1732,YicC_N k59_612858_1 1121372.AULK01000004_gene1393 2.96e-26 110.0 COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria,4FNYJ@85023|Microbacteriaceae 201174|Actinobacteria V Beta-lactamase lipE - - - - - - - - - - - Beta-lactamase k59_190756_1 42565.FP66_16205 1.75e-55 196.0 COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1XIJ8@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 1.3.1.12,2.5.1.19 ko:K00210,ko:K00800 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00022,M00025 R01728,R03460 RC00125,RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase,PDH k59_147378_1 1121918.ARWE01000001_gene1195 8.35e-34 127.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,42NI7@68525|delta/epsilon subdivisions,2WNPX@28221|Deltaproteobacteria,43U1Z@69541|Desulfuromonadales 28221|Deltaproteobacteria J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.21,5.4.99.22 ko:K06178,ko:K06182 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_147378_2 1121405.dsmv_2859 1.47e-18 84.7 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,42SVD@68525|delta/epsilon subdivisions,2WPFX@28221|Deltaproteobacteria,2MJWM@213118|Desulfobacterales 28221|Deltaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_1667771_1 234826.AM814 7.86e-47 170.0 COG3451@1|root,COG3451@2|Bacteria,1MXH0@1224|Proteobacteria,2TR1U@28211|Alphaproteobacteria,47F23@766|Rickettsiales 766|Rickettsiales U type IV secretion system protein virB4-1 - - ko:K03199 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - CagE_TrbE_VirB k59_930412_1 595460.RRSWK_06089 5.97e-10 62.0 COG0160@1|root,COG0160@2|Bacteria,2IX55@203682|Planctomycetes 203682|Planctomycetes H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_930412_2 331869.BAL199_28375 9.61e-19 90.1 COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,2U1MH@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Endonuclease Exonuclease Phosphatase - - - - - - - - - - - - Exo_endo_phos k59_1339735_1 1279017.AQYJ01000023_gene3253 9.39e-68 219.0 COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,1T1NH@1236|Gammaproteobacteria,46DC9@72275|Alteromonadaceae 1236|Gammaproteobacteria EGP Acetyl-coenzyme A transporter 1 ampG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015835,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1901264,GO:1902600 - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_1138797_1 1159870.KB907784_gene1444 4.69e-43 148.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VJ7N@28216|Betaproteobacteria,3T5TT@506|Alcaligenaceae 28216|Betaproteobacteria S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_1031320_1 1216976.AX27061_4733 1.71e-81 249.0 COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2VIMS@28216|Betaproteobacteria,3T6B5@506|Alcaligenaceae 28216|Betaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_303370_1 883077.HMPREF9241_01164 5.67e-20 94.0 COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4D4G3@85005|Actinomycetales 201174|Actinobacteria E Belongs to the DegT DnrJ EryC1 family degT - - - - - - - - - - - DegT_DnrJ_EryC1 k59_355419_1 1430440.MGMSRv2_0148 4.53e-66 229.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2TR6F@28211|Alphaproteobacteria,2JR6A@204441|Rhodospirillales 204441|Rhodospirillales C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_1545716_1 1472716.KBK24_0101330 5.46e-14 71.2 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VKRV@28216|Betaproteobacteria,1K4P6@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_1545716_2 1122135.KB893138_gene1149 2.62e-182 518.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Serine-pyruvate aminotransferase archaeal aspartate aminotransferase phnW - 2.6.1.37 ko:K03430 ko00440,ko01100,ko01120,map00440,map01100,map01120 - R04152 RC00008,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_5 k59_1339746_1 1274374.CBLK010000051_gene2072 1.18e-09 60.8 COG0163@1|root,COG0163@2|Bacteria,1V3JV@1239|Firmicutes,4HFZX@91061|Bacilli,26RDA@186822|Paenibacillaceae 91061|Bacilli H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_1339746_2 370438.PTH_1437 1.22e-09 58.9 COG0382@1|root,COG0382@2|Bacteria,1TQU5@1239|Firmicutes,2486B@186801|Clostridia,25ZZE@186807|Peptococcaceae 186801|Clostridia H PFAM UbiA prenyltransferase - - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_1667810_1 498761.HM1_3125 6.87e-10 60.5 2DSV3@1|root,33HII@2|Bacteria,1VQ64@1239|Firmicutes,24VWA@186801|Clostridia 186801|Clostridia S ORF located using Blastx - - - - - - - - - - - - - k59_147408_1 1122927.KB895415_gene4740 2.06e-41 154.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,4HAAG@91061|Bacilli,26QA6@186822|Paenibacillaceae 91061|Bacilli G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21,3.2.1.52 ko:K01207,ko:K05349 ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501 M00628 R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko00002,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_930444_2 2340.JV46_14330 7.8e-45 163.0 COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_1183545_1 268746.Q58ME8_BPPRM 1.84e-134 389.0 4QF76@10239|Viruses,4QZE5@35237|dsDNA viruses no RNA stage,4QQDU@28883|Caudovirales,4QJUE@10662|Myoviridae 10662|Myoviridae S DNA primase activity - - - - - - - - - - - - - k59_769774_1 1123279.ATUS01000002_gene2 4.16e-24 100.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1J5HC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0016491,GO:0016667,GO:0016672,GO:0016675,GO:0019538,GO:0030091,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0043546,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0048037,GO:0050662,GO:0050896,GO:0055114,GO:0071704,GO:0097159,GO:1901363,GO:1901530,GO:1901564,GO:1901700 - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_460745_1 436308.Nmar_0521 5.8e-38 132.0 COG1386@1|root,arCOG02613@2157|Archaea,41SIC@651137|Thaumarchaeota 651137|Thaumarchaeota K segregation and condensation protein - - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_405984_1 697281.Mahau_1760 4.48e-54 179.0 COG0407@1|root,COG0407@2|Bacteria,1V3M9@1239|Firmicutes,25AY7@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_977873_1 436308.Nmar_0554 1.36e-86 264.0 COG1060@1|root,arCOG00656@2157|Archaea,41SCN@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnC - - - - - - - - - - - Radical_SAM k59_1453758_1 436308.Nmar_0055 5.66e-160 469.0 COG1293@1|root,arCOG01695@2157|Archaea,41SB0@651137|Thaumarchaeota 651137|Thaumarchaeota K Fibronectin-binding protein A N-terminus (FbpA) - - - - - - - - - - - - DUF814,FbpA k59_1603994_1 444860.E3SJ46_9CAUD 2.6e-14 71.2 4QASV@10239|Viruses,4QQ4N@28883|Caudovirales,4QIBN@10662|Myoviridae 10662|Myoviridae S recA bacterial DNA recombination protein - - - - - - - - - - - - - k59_1603994_3 444860.E3SJ48_9CAUD 1.99e-17 80.5 4QAWG@10239|Viruses,4QV6X@35237|dsDNA viruses no RNA stage,4QPII@28883|Caudovirales,4QI76@10662|Myoviridae 10662|Myoviridae S DNA helicase activity - - - - - - - - - - - - - k59_460753_1 1379270.AUXF01000005_gene468 1.28e-23 100.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase menG - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_405990_1 1121374.KB891586_gene2776 9.41e-81 250.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,1RPYA@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) - - - - - - - - - - - - DUF2437,FAA_hydrolase k59_1603997_1 258594.RPA1384 1.29e-21 95.5 COG3639@1|root,COG3639@2|Bacteria,1MW4F@1224|Proteobacteria,2TTXJ@28211|Alphaproteobacteria,3K00E@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Binding-protein-dependent transport system inner membrane component phnE - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 k59_1603997_2 1434929.X946_609 1.33e-08 56.6 COG3638@1|root,COG3638@2|Bacteria,1MVE9@1224|Proteobacteria,2VIEZ@28216|Betaproteobacteria,1K508@119060|Burkholderiaceae 28216|Betaproteobacteria P Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system phnC - 3.6.3.28 ko:K02041 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.9 - - ABC_tran k59_1453770_1 1122925.KB895392_gene1622 2.37e-15 79.3 COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,4H9ZM@91061|Bacilli,26S70@186822|Paenibacillaceae 91061|Bacilli D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 2.4.2.8,6.3.4.19 ko:K04075,ko:K15780 ko00230,ko01100,ko01110,map00230,map01100,map01110 - R01132,R01229,R02142,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_1453770_2 1379270.AUXF01000003_gene3588 1.91e-06 48.1 COG4103@1|root,COG4103@2|Bacteria 2|Bacteria T Tellurite resistance protein TerB - - - - - - - - - - - - TerB k59_102062_1 436308.Nmar_1489 4.8e-106 319.0 COG0016@1|root,arCOG00410@2157|Archaea,41S9U@651137|Thaumarchaeota 651137|Thaumarchaeota J Phenylalanyl-tRNA synthetase alpha subunit - - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2d k59_720403_2 1224318.DT73_01210 3.9e-32 121.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1S0KW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Molecular chaperone GroES - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_303440_1 909663.KI867149_gene3452 3.66e-86 269.0 COG0057@1|root,COG0057@2|Bacteria,1R8ZT@1224|Proteobacteria,42PY6@68525|delta/epsilon subdivisions,2WKEI@28221|Deltaproteobacteria,2MR58@213462|Syntrophobacterales 28221|Deltaproteobacteria G Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain - - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_1246692_1 395493.BegalDRAFT_1750 3.71e-82 270.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,461RZ@72273|Thiotrichales 72273|Thiotrichales E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_521078_1 1123366.TH3_07122 6.97e-62 197.0 28Q4X@1|root,2ZCN0@2|Bacteria,1RA2A@1224|Proteobacteria,2U5RP@28211|Alphaproteobacteria,2JRTN@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_1031400_1 1283300.ATXB01000001_gene23 2.05e-22 102.0 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,1XE8Z@135618|Methylococcales 135618|Methylococcales M AsmA family - - - - - - - - - - - - AsmA k59_460794_2 1476902.A0A067ZG37_9CAUD 5.36e-06 51.2 4QBNM@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPUI@28883|Caudovirales,4QIGP@10662|Myoviridae 10662|Myoviridae S Clp protease - - - - - - - - - - - - - k59_147467_2 1118059.CAHC01000008_gene1238 7.33e-06 51.2 COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,249K8@186801|Clostridia,3WCH6@538999|Clostridiales incertae sedis 186801|Clostridia S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA - 2.7.7.85 ko:K18672 - - - - ko00000,ko01000 - - - DisA_N k59_1395172_1 926690.KE386573_gene1154 6.42e-12 65.1 COG0114@1|root,arCOG01749@2157|Archaea,2XT2J@28890|Euryarchaeota,23T2J@183963|Halobacteria 183963|Halobacteria C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_1395172_2 1207063.P24_08574 9.15e-37 129.0 COG4319@1|root,COG4319@2|Bacteria,1MZK9@1224|Proteobacteria,2U5AR@28211|Alphaproteobacteria,2JTW8@204441|Rhodospirillales 204441|Rhodospirillales S SnoaL-like domain - - - - - - - - - - - - SnoaL_3 k59_1395172_3 458817.Shal_1891 1.04e-29 113.0 COG0121@1|root,COG0121@2|Bacteria,1MU1J@1224|Proteobacteria,1RNEK@1236|Gammaproteobacteria,2Q9EE@267890|Shewanellaceae 1236|Gammaproteobacteria S PFAM glutamine amidotransferase, class-II yafJ - - - - - - - - - - - GATase_4 k59_18746_1 667014.Thein_1717 1.39e-136 418.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GHDG@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_930518_1 1280390.CBQR020000058_gene1121 7.39e-13 68.9 COG2352@1|root,COG2352@2|Bacteria,1TQB6@1239|Firmicutes,4HCAF@91061|Bacilli,26QIW@186822|Paenibacillaceae 91061|Bacilli C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_720448_1 391600.ABRU01000039_gene2007 6.65e-45 155.0 COG1985@1|root,COG1985@2|Bacteria,1N4VZ@1224|Proteobacteria,2TXAC@28211|Alphaproteobacteria,2KGTP@204458|Caulobacterales 204458|Caulobacterales H RibD C-terminal domain - - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C k59_1514514_1 998674.ATTE01000001_gene3750 1.73e-28 110.0 COG1714@1|root,COG1714@2|Bacteria,1MZAD@1224|Proteobacteria,1S6E9@1236|Gammaproteobacteria,462QZ@72273|Thiotrichales 72273|Thiotrichales S RDD family - - - - - - - - - - - - RDD k59_1088123_1 449447.MAE_60310 3.98e-96 289.0 COG0031@1|root,COG0031@2|Bacteria,1G1AB@1117|Cyanobacteria 1117|Cyanobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1184554_1 314230.DSM3645_04360 1.47e-160 472.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2IXH6@203682|Planctomycetes 203682|Planctomycetes C Pyruvate ferredoxin oxidoreductase and related - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1140279_1 268746.Q58MN3_BPPRM 2.75e-83 262.0 4QDJF@10239|Viruses,4QVQ0@35237|dsDNA viruses no RNA stage,4QR89@28883|Caudovirales,4QICF@10662|Myoviridae 10662|Myoviridae S Virus neck protein - GO:0005575,GO:0019012 - - - - - - - - - - - k59_19252_1 395965.Msil_1741 2.33e-140 415.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,3N9VZ@45404|Beijerinckiaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase type 2 domain - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_19252_2 395493.BegalDRAFT_3013 1.34e-179 514.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Electron transfer flavoprotein-ubiquinone oxidoreductase etfD - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8,Thi4 k59_931767_1 706587.Desti_5090 6.16e-39 145.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2MQZ3@213462|Syntrophobacterales 28221|Deltaproteobacteria IQ Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - 6.2.1.34 ko:K00666,ko:K12508 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1184568_1 945713.IALB_0893 4.04e-17 80.9 COG1034@1|root,COG3383@1|root,COG1034@2|Bacteria,COG3383@2|Bacteria 2|Bacteria C formate dehydrogenase (NAD+) activity nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_356710_2 446471.Xcel_1958 6.02e-32 130.0 COG3497@1|root,COG3497@2|Bacteria,2IG6A@201174|Actinobacteria 201174|Actinobacteria S Phage tail sheath protein subtilisin-like domain - - - ko:K06907 - - - - ko00000 - - - Phage_sheath_1,Phage_sheath_1C k59_356714_1 1124983.PFLCHA0_c12030 1.31e-12 75.1 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1YPP6@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria M zinc metalloprotease rseP GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_1514843_1 1411685.U062_00680 1.27e-05 53.1 COG4773@1|root,COG4773@2|Bacteria,1MWUQ@1224|Proteobacteria,1SJYF@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1567087_1 484018.BACPLE_00230 3.92e-49 159.0 COG1694@1|root,COG1694@2|Bacteria,4NQ3H@976|Bacteroidetes,2FT28@200643|Bacteroidia,4AQWU@815|Bacteroidaceae 976|Bacteroidetes S MazG nucleotide pyrophosphohydrolase domain ypjD - - - - - - - - - - - MazG k59_992523_1 414684.RC1_3648 1.24e-70 223.0 COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2TS6D@28211|Alphaproteobacteria,2JQUH@204441|Rhodospirillales 204441|Rhodospirillales F Belongs to the pseudomonas-type ThrB family thrB - 2.7.1.39 ko:K02204 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - APH k59_261235_1 1223410.KN050846_gene2812 2.34e-24 107.0 COG1572@1|root,COG2010@1|root,COG1572@2|Bacteria,COG2010@2|Bacteria,4NJ3E@976|Bacteroidetes,1IK72@117743|Flavobacteriia 976|Bacteroidetes C Domain of unknown function (DUF5122) beta-propeller - - - - - - - - - - - - DUF5122 k59_156752_1 663610.JQKO01000001_gene953 3.76e-33 117.0 COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2U95D@28211|Alphaproteobacteria,3NB6F@45404|Beijerinckiaceae 28211|Alphaproteobacteria J structural constituent of ribosome rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_156752_2 396588.Tgr7_2324 3.49e-94 281.0 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,1RMK9@1236|Gammaproteobacteria,1WVZS@135613|Chromatiales 135613|Chromatiales J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_731353_1 1121272.KB903289_gene4225 1.63e-52 178.0 COG3173@1|root,COG3173@2|Bacteria,2GSTN@201174|Actinobacteria,4DJK3@85008|Micromonosporales 201174|Actinobacteria S Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_121_1 573370.DMR_20450 1.5e-23 104.0 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2WJGZ@28221|Deltaproteobacteria,2M9Y5@213115|Desulfovibrionales 28221|Deltaproteobacteria S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_313473_1 472759.Nhal_1926 5.91e-44 152.0 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1WW5P@135613|Chromatiales 135613|Chromatiales J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_313473_2 713587.THITH_06075 5.01e-34 126.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,1WWQ8@135613|Chromatiales 135613|Chromatiales J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_470181_1 1229909.NSED_00065 2.14e-85 253.0 COG1881@1|root,arCOG04702@2157|Archaea,41T4M@651137|Thaumarchaeota 651137|Thaumarchaeota S Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_104527_1 648885.KB316283_gene3352 2.13e-102 312.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TW3C@28211|Alphaproteobacteria,1JR1I@119045|Methylobacteriaceae 28211|Alphaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_522419_1 1121939.L861_12215 2.17e-77 246.0 COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1XINT@135619|Oceanospirillales 135619|Oceanospirillales O COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component sufD - - ko:K09015 - - - - ko00000 - - - UPF0051 k59_940293_1 366602.Caul_3170 3.25e-32 123.0 COG2021@1|root,COG2021@2|Bacteria,1QU6N@1224|Proteobacteria,2TXCU@28211|Alphaproteobacteria,2KIFJ@204458|Caulobacterales 204458|Caulobacterales E TAP-like protein - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_1253709_2 472759.Nhal_3586 1.42e-35 135.0 COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,1RN7H@1236|Gammaproteobacteria,1X0IX@135613|Chromatiales 135613|Chromatiales S PFAM peptidase S15 - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_522428_1 1185876.BN8_04722 4.64e-63 202.0 COG0823@1|root,COG0823@2|Bacteria,4NG4S@976|Bacteroidetes,47KMG@768503|Cytophagia 976|Bacteroidetes U WD40-like Beta Propeller Repeat tolB3 - - - - - - - - - - - PD40 k59_679179_1 370438.PTH_0295 8.23e-60 201.0 COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,2609V@186807|Peptococcaceae 186801|Clostridia J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_783631_2 1280686.AUKE01000007_gene1771 0.000914 42.7 COG4284@1|root,COG4284@2|Bacteria,1TQUD@1239|Firmicutes,24A8D@186801|Clostridia,4BYB1@830|Butyrivibrio 186801|Clostridia G UTP--glucose-1-phosphate uridylyltransferase - - 2.7.7.23,2.7.7.83 ko:K00972 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00361,M00362 R00416 RC00002 ko00000,ko00001,ko00002,ko01000 - - - UDPGP k59_1305953_1 675812.VHA_001382 3.72e-107 323.0 COG1748@1|root,COG1748@2|Bacteria,1NIU2@1224|Proteobacteria,1RP49@1236|Gammaproteobacteria,1XVG7@135623|Vibrionales 135623|Vibrionales E COG1748 Saccharopine dehydrogenase and related proteins - - 1.5.1.43 ko:K13746 ko00330,ko01100,map00330,map01100 - R09079,R09080 RC00053,RC00225 ko00000,ko00001,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_1044782_1 1268068.PG5_56280 1.22e-48 159.0 COG1226@1|root,31669@2|Bacteria,1RIW0@1224|Proteobacteria,1S6HC@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1226 Kef-type K transport systems - - - - - - - - - - - - Ion_trans_2 k59_417963_1 1173024.KI912148_gene3523 2.45e-86 268.0 COG2403@1|root,COG2403@2|Bacteria,1G1FF@1117|Cyanobacteria 1117|Cyanobacteria S cyclic 2,3-diphosphoglycerate synthetase activity - - - - - - - - - - - - cobW k59_104547_1 404589.Anae109_0680 5.33e-12 68.6 COG4969@1|root,COG4969@2|Bacteria 2|Bacteria NU cell adhesion - - - ko:K02650 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - N_methyl,Pilin k59_992568_1 457424.BFAG_04095 4.5e-08 56.6 COG1013@1|root,COG1013@2|Bacteria,4NIE0@976|Bacteroidetes,2FME7@200643|Bacteroidia,4AKME@815|Bacteroidaceae 976|Bacteroidetes C COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oorB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_992568_2 309799.DICTH_0588 3.45e-20 89.4 COG0157@1|root,COG0157@2|Bacteria 2|Bacteria H quinolinate catabolic process nadC GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 1.4.3.16,2.4.2.19 ko:K00278,ko:K00767 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481,R03348 RC00006,RC02566,RC02877 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1988,iHN637.CLJU_RS12010,iLJ478.TM1645 QRPTase_C,QRPTase_N k59_1149257_1 290397.Adeh_3681 6.09e-63 203.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,42N3J@68525|delta/epsilon subdivisions,2WJ19@28221|Deltaproteobacteria,2YUVT@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_1514877_1 443144.GM21_2333 2.53e-47 172.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,43SYQ@69541|Desulfuromonadales 28221|Deltaproteobacteria H Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 k59_1253734_1 1267535.KB906767_gene4345 4.85e-54 190.0 COG0668@1|root,COG0668@2|Bacteria,3Y6BI@57723|Acidobacteria 57723|Acidobacteria M Mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_679213_1 1209072.ALBT01000061_gene973 0.000243 44.7 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,1RNKH@1236|Gammaproteobacteria,1FGW6@10|Cellvibrio 1236|Gammaproteobacteria S Divergent polysaccharide deacetylase yibQ - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_679213_2 318167.Sfri_0473 1.79e-10 65.1 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,2Q9XB@267890|Shewanellaceae 1236|Gammaproteobacteria H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 - ko:K03688 - - - - ko00000 - - iYL1228.KPN_04331 ABC1 k59_626982_1 272630.MexAM1_META1p4677 2.97e-06 52.4 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2TTUM@28211|Alphaproteobacteria,1JSKK@119045|Methylobacteriaceae 28211|Alphaproteobacteria CO Disulphide bond corrector protein DsbC dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_1305976_1 1163617.SCD_n00097 2.81e-92 279.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2VIR9@28216|Betaproteobacteria 28216|Betaproteobacteria D Cell shape determining protein, MreB Mrl family mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_1305976_2 1123487.KB892834_gene2787 6.96e-33 116.0 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2VUFB@28216|Betaproteobacteria,2KWWQ@206389|Rhodocyclales 206389|Rhodocyclales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_1410442_1 1121403.AUCV01000029_gene2706 2.54e-12 66.2 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,42MPM@68525|delta/epsilon subdivisions,2WKPX@28221|Deltaproteobacteria,2MNGM@213118|Desulfobacterales 28221|Deltaproteobacteria F Formyl transferase purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,Formyl_trans_N k59_1410442_2 1244869.H261_06576 1.22e-25 112.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,2JRZP@204441|Rhodospirillales 204441|Rhodospirillales C B12 binding domain - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_365809_1 1461694.ATO9_20660 2.3e-48 163.0 COG1024@1|root,COG1024@2|Bacteria,1MWGT@1224|Proteobacteria,2TV7F@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - - - - - - - - - - - ECH_1 k59_626992_1 1223544.GSI01S_06_01650 9.87e-44 162.0 COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4GBSY@85026|Gordoniaceae 201174|Actinobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - iNJ661.Rv2158c Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_732244_2 1265502.KB905932_gene1926 1.91e-91 278.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHD3@28216|Betaproteobacteria,4A9Q4@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein ivd - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1620186_1 1226325.HMPREF1548_00216 5.53e-26 107.0 COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,1TT86@1239|Firmicutes,247QE@186801|Clostridia,36G52@31979|Clostridiaceae 186801|Clostridia L Psort location Cytoplasmic, score 9.97 - - - - - - - - - - - - UvrD-helicase,UvrD_C k59_314334_1 740709.A10D4_05767 7.78e-61 192.0 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,1S3PX@1236|Gammaproteobacteria,2QG3Z@267893|Idiomarinaceae 1236|Gammaproteobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ GO:0003674,GO:0003824,GO:0003855,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_314334_2 317013.NY99_00050 3.25e-07 51.6 COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,1X67R@135614|Xanthomonadales 135614|Xanthomonadales I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl k59_470873_2 1304275.C41B8_11653 3.26e-30 119.0 COG1562@1|root,COG1657@1|root,COG1562@2|Bacteria,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,1S118@1236|Gammaproteobacteria 1236|Gammaproteobacteria I PFAM Prenyltransferase squalene oxidase shc - 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 - R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 - - - SQHop_cyclase_C,SQHop_cyclase_N k59_627998_1 1223521.BBJX01000007_gene1552 1.97e-87 268.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,4AB13@80864|Comamonadaceae 28216|Betaproteobacteria NU PFAM Type II secretion system protein E pilU - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1202568_1 314260.PB2503_09499 5.38e-09 55.8 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,2TQPF@28211|Alphaproteobacteria 28211|Alphaproteobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_1202568_2 596152.DesU5LDRAFT_3609 2.62e-61 190.0 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,42RHR@68525|delta/epsilon subdivisions,2WNEK@28221|Deltaproteobacteria,2MBG6@213115|Desulfovibrionales 28221|Deltaproteobacteria J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_1202568_3 1121406.JAEX01000006_gene2293 2.36e-12 62.4 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,42TNS@68525|delta/epsilon subdivisions,2WR6G@28221|Deltaproteobacteria,2MCN3@213115|Desulfovibrionales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_575539_1 381666.H16_A1475 5e-21 92.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2VHQ8@28216|Betaproteobacteria,1KCPQ@119060|Burkholderiaceae 28216|Betaproteobacteria E Peptidase family M28 amaB1 - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_575539_2 1218352.B597_002410 2.57e-11 65.9 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1Z03C@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase - - 1.2.5.1,2.2.1.6,4.1.1.7 ko:K00156,ko:K01576,ko:K01652 ko00290,ko00620,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00620,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R01764,R02672,R03050,R03145,R04672,R04673,R08648 RC00027,RC00106,RC00595,RC00860,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_53391_1 330214.NIDE2480 6.92e-121 350.0 COG1398@1|root,COG1398@2|Bacteria 2|Bacteria I oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water desC - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_262128_1 443152.MDG893_13968 3.11e-15 78.6 2DA4I@1|root,32TUN@2|Bacteria,1N0WK@1224|Proteobacteria,1S6HI@1236|Gammaproteobacteria,467DY@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_575540_1 98439.AJLL01000097_gene2048 2.34e-22 99.0 COG1216@1|root,COG1216@2|Bacteria,1G2ZC@1117|Cyanobacteria,1JGZ4@1189|Stigonemataceae 1117|Cyanobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_470877_1 43354.JOIJ01000009_gene2946 2.41e-75 239.0 COG1509@1|root,COG1509@2|Bacteria,2GM2P@201174|Actinobacteria,4DZUR@85010|Pseudonocardiales 201174|Actinobacteria E Lysine 2,3-aminomutase kamA - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - - k59_836744_1 1279017.AQYJ01000029_gene3542 1.4e-117 357.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMXI@1236|Gammaproteobacteria,464BP@72275|Alteromonadaceae 1236|Gammaproteobacteria E Peptidase family M3 dcp - 3.4.15.5 ko:K01284 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_732267_1 1173025.GEI7407_0453 2.18e-16 83.6 COG1193@1|root,COG1193@2|Bacteria,1G1GB@1117|Cyanobacteria,1H6Y5@1150|Oscillatoriales 1117|Cyanobacteria L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr k59_470880_1 105559.Nwat_1080 2.58e-36 128.0 COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria,1WXC4@135613|Chromatiales 135613|Chromatiales L Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH - - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX k59_470880_2 1232410.KI421412_gene2 4.63e-12 71.2 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,42N4G@68525|delta/epsilon subdivisions,2WJ8A@28221|Deltaproteobacteria,43TCG@69541|Desulfuromonadales 28221|Deltaproteobacteria M HlyD family secretion protein - - - ko:K03585,ko:K07799 ko01501,ko01503,ko02020,map01501,map01503,map02020 M00646,M00647,M00648,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1,8.A.1.6 - - HlyD_D23 k59_470885_2 187272.Mlg_0471 8.65e-30 108.0 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,1S62N@1236|Gammaproteobacteria,1WYNJ@135613|Chromatiales 135613|Chromatiales J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_366676_1 43989.cce_2436 5.41e-08 58.2 2EZ9B@1|root,33SF2@2|Bacteria,1GCVX@1117|Cyanobacteria,3KJ46@43988|Cyanothece 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_628038_1 1163617.SCD_n02833 0.000316 47.8 COG4222@1|root,COG4222@2|Bacteria,1N0B0@1224|Proteobacteria,2VJBV@28216|Betaproteobacteria 28216|Betaproteobacteria C Esterase-like activity of phytase - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - Phytase-like k59_993323_1 1121271.AUCM01000008_gene3193 9.9e-26 107.0 COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,2TRUP@28211|Alphaproteobacteria 28211|Alphaproteobacteria S virion core protein (lumpy skin disease virus) ydjI - - - - - - - - - - - Band_7_1,DUF4339,SHOCT k59_1306657_2 1120951.AUBG01000015_gene3476 0.000363 47.8 COG2227@1|root,COG2227@2|Bacteria,4NGVF@976|Bacteroidetes,1HXGK@117743|Flavobacteriia 976|Bacteroidetes H Methyltransferase - - - - - - - - - - - - Methyltransf_23 k59_857_1 935261.JAGL01000030_gene301 4.37e-56 197.0 COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,43H7U@69277|Phyllobacteriaceae 28211|Alphaproteobacteria CJ COG1042 Acyl-CoA synthetase (NDP forming) MA20_38090 - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_1045683_1 675635.Psed_1330 9.73e-12 71.2 arCOG06766@1|root,2Z87F@2|Bacteria,2IAM6@201174|Actinobacteria,4E7V9@85010|Pseudonocardiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1254732_1 488538.SAR116_2097 2.2e-77 239.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TRT1@28211|Alphaproteobacteria,4BT7W@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P ATPases associated with a variety of cellular activities - - - ko:K02049,ko:K15555 ko00920,ko02010,map00920,map02010 M00188,M00436 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16,3.A.1.17,3.A.1.17.2 - - ABC_tran k59_836775_1 936053.I1BHE5 4.93e-13 74.7 COG1960@1|root,KOG0139@2759|Eukaryota,38H6J@33154|Opisthokonta,3NWK6@4751|Fungi,1GWQ4@112252|Fungi incertae sedis 4751|Fungi E Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_836775_2 987059.RBXJA2T_04503 2.06e-31 123.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,1KJJ2@119065|unclassified Burkholderiales 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA2 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_470897_1 1123393.KB891330_gene855 9.33e-65 208.0 COG1132@1|root,COG1132@2|Bacteria,1MX5V@1224|Proteobacteria,2WBNB@28216|Betaproteobacteria,1KS8Q@119069|Hydrogenophilales 119069|Hydrogenophilales V (ABC) transporter - - - - - - - - - - - - - k59_1620241_1 1121940.AUDZ01000014_gene1251 7.78e-21 82.8 COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,1SCEJ@1236|Gammaproteobacteria,1XMCR@135619|Oceanospirillales 135619|Oceanospirillales J there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc rpmG - - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 k59_1620241_2 225937.HP15_1045 1.35e-21 89.7 COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,1S5ZK@1236|Gammaproteobacteria,467GP@72275|Alteromonadaceae 1236|Gammaproteobacteria C Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions fdxA - - ko:K05524 - - - - ko00000 - - - DUF3470,Fer4,Fer4_9 k59_109320_1 997350.HMPREF9129_0280 5.18e-10 60.8 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,22GN2@1570339|Peptoniphilaceae 186801|Clostridia V ABC transporter, ATP-binding protein - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_109320_2 671143.DAMO_2494 5.61e-05 51.2 COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria 2|Bacteria V ABC transporter MdlB - - ko:K06147,ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1311027_1 398579.Spea_1710 2.51e-47 167.0 COG0531@1|root,COG0531@2|Bacteria,1NCSX@1224|Proteobacteria,1RND7@1236|Gammaproteobacteria,2Q92S@267890|Shewanellaceae 1236|Gammaproteobacteria E PFAM amino acid permease-associated region yjeH GO:0000099,GO:0000101,GO:0000102,GO:0001101,GO:0003333,GO:0003674,GO:0005215,GO:0005294,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015191,GO:0015238,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015821,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043200,GO:0043865,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:1901680,GO:1901682,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - ko:K03757,ko:K03759,ko:K16263 - - - - ko00000,ko02000 2.A.3.13,2.A.3.2 - - AA_permease_2 k59_214131_1 1196031.ALEG01000039_gene1825 8.86e-36 139.0 COG1196@1|root,COG5283@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,1UHQM@1239|Firmicutes,4HGW7@91061|Bacilli,1ZBWW@1386|Bacillus 91061|Bacilli D phage tail tape measure protein - - - - - - - - - - - - Peptidase_M23,PhageMin_Tail,SLT k59_1260258_1 1517416.IDAT_04850 1.51e-24 95.1 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,2QG9C@267893|Idiomarinaceae 1236|Gammaproteobacteria J seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing yhbH GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_1260258_2 187272.Mlg_2232 5.94e-48 159.0 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,1S668@1236|Gammaproteobacteria,1WYAA@135613|Chromatiales 135613|Chromatiales G PTS IIA-like nitrogen-regulatory protein PtsN - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_1260258_3 1411685.U062_01131 2.15e-25 103.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1J528@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Displays ATPase and GTPase activities rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_633461_1 243233.MCA2265 6.42e-13 65.1 COG0346@1|root,COG0346@2|Bacteria,1RHIV@1224|Proteobacteria,1S6V6@1236|Gammaproteobacteria,1XF5Q@135618|Methylococcales 135618|Methylococcales E glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_633461_2 1292034.OR37_02173 7.41e-34 120.0 COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,2U9NV@28211|Alphaproteobacteria,2KH38@204458|Caulobacterales 204458|Caulobacterales K arsR family - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_20 k59_1363424_1 1267533.KB906736_gene845 1.29e-59 207.0 COG0178@1|root,COG0178@2|Bacteria,3Y3PA@57723|Acidobacteria,2JISM@204432|Acidobacteriia 204432|Acidobacteriia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_214138_2 671143.DAMO_0159 6.05e-27 103.0 2DMP9@1|root,32SV1@2|Bacteria 2|Bacteria S Protein of unknown function (DUF3015) - - - - - - - - - - - - DUF3015 k59_945129_1 1046724.KB889880_gene1924 7.46e-27 109.0 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,4640D@72275|Alteromonadaceae 1236|Gammaproteobacteria M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella mltF GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030312,GO:0030313,GO:0031975,GO:0043170,GO:0044462,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - ko:K18691 - - - - ko00000,ko01000,ko01011 - - iBWG_1329.BWG_2322,iEC042_1314.EC042_2762,iECDH1ME8569_1439.ECDH1ME8569_2485,iECNA114_1301.ECNA114_2631,iECP_1309.ECP_2560,iECSF_1327.ECSF_2397,iECW_1372.ECW_m2786,iEKO11_1354.EKO11_1175,iEcDH1_1363.EcDH1_1110,iEcHS_1320.EcHS_A2711,iEcolC_1368.EcolC_1119,iG2583_1286.G2583_3089,iJO1366.b2558,iSFxv_1172.SFxv_2861,iUMN146_1321.UM146_03930,iUMNK88_1353.UMNK88_3212,iUTI89_1310.UTI89_C2878,iWFL_1372.ECW_m2786,iY75_1357.Y75_RS13345 SBP_bac_3,SLT k59_945129_2 1313172.YM304_02670 9.49e-18 79.3 COG0590@1|root,COG0590@2|Bacteria,2IM3Z@201174|Actinobacteria,4CN9M@84992|Acidimicrobiia 84992|Acidimicrobiia F Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam k59_1102374_1 455436.DS989814_gene914 1.59e-70 225.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,464WJ@72275|Alteromonadaceae 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_841091_2 331869.BAL199_06901 5.01e-37 128.0 COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,2U9G3@28211|Alphaproteobacteria 28211|Alphaproteobacteria O redox protein regulator of disulfide bond formation yhfA - - ko:K07397 - - - - ko00000 - - - OsmC k59_1050077_1 330214.NIDE4324 3.94e-33 124.0 COG1446@1|root,COG1446@2|Bacteria,3J19S@40117|Nitrospirae 40117|Nitrospirae E Asparaginase - - 3.4.19.5 ko:K13051 - - - - ko00000,ko01000,ko01002 - - - Asparaginase_2 k59_1050077_2 179408.Osc7112_0142 5.07e-25 97.4 COG3565@1|root,COG3565@2|Bacteria,1G5U6@1117|Cyanobacteria,1HB11@1150|Oscillatoriales 1117|Cyanobacteria S dioxygenase of extradiol dioxygenase family - - - ko:K06991 - - - - ko00000 - - - Glyoxalase k59_58830_2 998674.ATTE01000001_gene491 6.68e-39 134.0 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,4613Z@72273|Thiotrichales 72273|Thiotrichales K regulatory protein, arsR - - - - - - - - - - - - HTH_5 k59_685584_1 1519464.HY22_05410 2.42e-39 148.0 COG0363@1|root,COG2120@1|root,COG0363@2|Bacteria,COG2120@2|Bacteria 2|Bacteria S N-acetylglucosaminylinositol deacetylase activity nagB - 3.1.1.31,3.5.99.6 ko:K01057,ko:K02564 ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R00765,R02035 RC00163,RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso,PIG-L k59_527467_1 547163.BN979_05673 3.99e-123 360.0 COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,233WB@1762|Mycobacteriaceae 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_527467_2 1341646.CBMO010000137_gene2321 2.09e-09 57.0 COG2124@1|root,COG2124@2|Bacteria,2GKKN@201174|Actinobacteria,23477@1762|Mycobacteriaceae 201174|Actinobacteria Q cytochrome p450 - - 1.14.15.13 ko:K17474 - - - - ko00000,ko00199,ko01000 - - - p450 k59_109342_1 765914.ThisiDRAFT_1023 3.43e-59 199.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1WW7K@135613|Chromatiales 135613|Chromatiales T GTP-binding protein TypA - - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_1209362_1 211165.AJLN01000042_gene521 3.54e-30 115.0 28IMV@1|root,2Z8NA@2|Bacteria,1G2BR@1117|Cyanobacteria,1JHWX@1189|Stigonemataceae 1117|Cyanobacteria S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - - k59_1416574_1 1333998.M2A_0744 3.53e-64 219.0 COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,2U1SX@28211|Alphaproteobacteria,4BPZ2@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria N ABC-type uncharacterized transport system - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_transp_aux k59_842002_1 83406.HDN1F_01010 5.87e-15 76.3 COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Uroporphyrinogen-III synthase hemD GO:0003674,GO:0003824,GO:0004852,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0187,iSBO_1134.SBO_3815 HEM4 k59_842002_2 472759.Nhal_3934 1.61e-39 154.0 COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RNJY@1236|Gammaproteobacteria,1WZTH@135613|Chromatiales 135613|Chromatiales H HemX, putative uroporphyrinogen-III C-methyltransferase - - 2.1.1.107 ko:K02496 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000 - - - HemX k59_1261455_1 1268622.AVS7_00586 8.24e-71 231.0 COG0668@1|root,COG0668@2|Bacteria,1MXH4@1224|Proteobacteria,2VM0E@28216|Betaproteobacteria,4AJT7@80864|Comamonadaceae 28216|Betaproteobacteria M Conserved TM helix - - - - - - - - - - - - TM_helix k59_320134_2 748247.AZKH_3552 1.11e-09 62.0 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,2VH49@28216|Betaproteobacteria,2KU7Z@206389|Rhodocyclales 206389|Rhodocyclales G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB - - ko:K19804 - - - - ko00000 - - - TPR_16 k59_737472_1 1041146.ATZB01000010_gene4063 7.9e-46 165.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,4B97F@82115|Rhizobiaceae 28211|Alphaproteobacteria H Aminotransferase class-III - - - - - - - - - - - - Aminotran_3 k59_528399_1 1167006.UWK_03284 1.01e-99 301.0 COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42NUN@68525|delta/epsilon subdivisions,2WJHN@28221|Deltaproteobacteria,2MHX4@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_528399_2 1167006.UWK_03285 7.29e-25 99.8 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,43AKQ@68525|delta/epsilon subdivisions,2X60P@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM 4Fe-4S - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11,Fer4_4 k59_1364397_1 502025.Hoch_2382 2.35e-85 271.0 COG0539@1|root,COG2183@1|root,COG0539@2|Bacteria,COG2183@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2YU9B@29|Myxococcales 28221|Deltaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_1364397_2 1283300.ATXB01000001_gene868 2.68e-05 48.9 COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,1T20F@1236|Gammaproteobacteria,1XEQW@135618|Methylococcales 135618|Methylococcales E Prephenate dehydrogenase - - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_791265_1 485913.Krac_7826 3.37e-28 117.0 COG0631@1|root,COG0631@2|Bacteria,2G6R4@200795|Chloroflexi 200795|Chloroflexi T SMART protein phosphatase 2C domain protein - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_267513_2 314278.NB231_09438 8.96e-42 139.0 COG3785@1|root,COG3785@2|Bacteria,1RHM7@1224|Proteobacteria,1T11M@1236|Gammaproteobacteria,1X1AJ@135613|Chromatiales 135613|Chromatiales S Hemimethylated DNA-binding protein YccV like - - - ko:K11940 - - - - ko00000,ko03036 - - - YccV-like k59_580797_1 1033802.SSPSH_000373 1.74e-72 237.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1RMHR@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2015 Alkyl sulfatase and related hydrolases - - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_1625498_1 1262915.BN574_01473 6.29e-79 259.0 COG0021@1|root,COG0021@2|Bacteria,1TPIB@1239|Firmicutes,4H2JE@909932|Negativicutes 909932|Negativicutes G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_1625498_3 1088721.NSU_0165 1.56e-12 69.3 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2TRUB@28211|Alphaproteobacteria,2JZWI@204457|Sphingomonadales 204457|Sphingomonadales L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1261481_2 1207076.ALAT01000168_gene3758 2.26e-63 197.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1Z2FR@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_634713_2 98439.AJLL01000047_gene2893 1.92e-53 183.0 COG1171@1|root,COG1171@2|Bacteria,1G22X@1117|Cyanobacteria 1117|Cyanobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - iJN678.ilvA PALP,Thr_dehydrat_C k59_215102_2 83406.HDN1F_03610 2.71e-70 216.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1J5QN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_215102_3 1121878.AUGL01000035_gene97 2.12e-73 221.0 COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,1S3WB@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL GO:0000372,GO:0000375,GO:0000376,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015935,GO:0016070,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0031323,GO:0031325,GO:0032991,GO:0033120,GO:0034336,GO:0034337,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043484,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_161048_1 414684.RC1_0905 1.98e-104 312.0 COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2TS5P@28211|Alphaproteobacteria,2JQTH@204441|Rhodospirillales 204441|Rhodospirillales S protein conserved in bacteria - - - ko:K09989 - - - - ko00000 - - - VWA_CoxE k59_3241_1 330214.NIDE3190 4.02e-97 301.0 COG2234@1|root,COG2234@2|Bacteria 2|Bacteria DZ aminopeptidase activity - - - - - - - - - - - - PA,Peptidase_M28 k59_1519136_1 196490.AUEZ01000018_gene3324 5.58e-66 210.0 COG5285@1|root,COG5285@2|Bacteria,1R7DG@1224|Proteobacteria,2TTB2@28211|Alphaproteobacteria,3K2AS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Phytanoyl-CoA dioxygenase (PhyH) - - - - - - - - - - - - PhyH k59_161049_1 1238450.VIBNISOn1_770085 5.09e-117 349.0 COG1653@1|root,COG1653@2|Bacteria,1MVMW@1224|Proteobacteria,1RSCM@1236|Gammaproteobacteria,1XW2H@135623|Vibrionales 135623|Vibrionales G Bacterial extracellular solute-binding protein - - - ko:K05813 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.3 - - SBP_bac_8 k59_161049_2 1380394.JADL01000007_gene4649 1.15e-13 72.4 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JQQE@204441|Rhodospirillales 204441|Rhodospirillales E COG3839 ABC-type sugar transport systems, ATPase components - - 3.6.3.20 ko:K05816 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1.3 - - ABC_tran,TOBE_2 k59_371900_1 519989.ECTPHS_05521 5.72e-91 277.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,1WWQ8@135613|Chromatiales 135613|Chromatiales J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_371900_2 105559.Nwat_2197 5.15e-21 86.3 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,1S9NV@1236|Gammaproteobacteria,1WYM1@135613|Chromatiales 135613|Chromatiales U TIGRFAM preprotein translocase, YajC subunit - - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_1625529_1 1504672.669786782 3.64e-71 228.0 COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,2VN37@28216|Betaproteobacteria,4ACP0@80864|Comamonadaceae 28216|Betaproteobacteria E N-formylglutamate amidohydrolase - - 3.5.1.68 ko:K01458 ko00340,ko00630,map00340,map00630 - R00525 RC00165,RC00323 ko00000,ko00001,ko01000 - - - FGase k59_161059_1 501479.ACNW01000091_gene2212 1.55e-33 133.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs iorB - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_1103379_1 2340.JV46_14320 7.8e-25 97.8 COG0636@1|root,COG0636@2|Bacteria,1N5D3@1224|Proteobacteria,1SBV1@1236|Gammaproteobacteria 1236|Gammaproteobacteria U ATP synthase subunit C - - - ko:K02124 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_C k59_998378_2 1128427.KB904821_gene3576 5.55e-18 85.9 COG0053@1|root,COG0053@2|Bacteria,1G0RT@1117|Cyanobacteria,1H71G@1150|Oscillatoriales 1117|Cyanobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_1364460_2 518766.Rmar_2013 5.14e-98 291.0 COG4314@1|root,COG4314@2|Bacteria,4NIPU@976|Bacteroidetes,1FJJY@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C lipoprotein involved in nitrous oxide reduction - - - ko:K19342 - - - - ko00000 - - - NosL k59_1364460_3 1268622.AVS7_01315 2.58e-16 82.4 COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,2VIYN@28216|Betaproteobacteria,4ABPR@80864|Comamonadaceae 28216|Betaproteobacteria P Parallel beta-helix repeat nosD - - ko:K07218 - - - - ko00000 - - - NosD k59_424195_1 1205753.A989_03070 1.37e-35 129.0 COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,1RNV4@1236|Gammaproteobacteria,1X34B@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the multicopper oxidase YfiH RL5 family - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_424195_2 472759.Nhal_2686 5.88e-65 207.0 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,1WVXU@135613|Chromatiales 135613|Chromatiales H Belongs to the NadC ModD family - - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_634757_1 357808.RoseRS_3778 3.54e-77 243.0 COG0275@1|root,COG0275@2|Bacteria,2G658@200795|Chloroflexi,374SY@32061|Chloroflexia 32061|Chloroflexia J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_634757_2 515620.EUBELI_00725 1.69e-26 104.0 COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia,25X03@186806|Eubacteriaceae 186801|Clostridia K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ k59_528474_1 330214.NIDE4145 7.12e-87 269.0 COG1004@1|root,COG1004@2|Bacteria,3J0EJ@40117|Nitrospirae 40117|Nitrospirae C Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1103391_2 1304888.ATWF01000001_gene2096 9.54e-23 89.7 COG0238@1|root,COG0238@2|Bacteria,2GFVY@200930|Deferribacteres 200930|Deferribacteres J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_1103391_3 1321784.HMPREF1987_01311 2.67e-28 108.0 COG0359@1|root,COG0359@2|Bacteria,1V6QG@1239|Firmicutes,24MT6@186801|Clostridia 186801|Clostridia J Binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_686865_1 1049564.TevJSym_ab00170 3.36e-70 223.0 COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,1S03J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Major facilitator superfamily - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_60183_1 502025.Hoch_6685 7.55e-60 193.0 COG2126@1|root,COG2126@2|Bacteria,1MXCS@1224|Proteobacteria,42NVQ@68525|delta/epsilon subdivisions,2WJFT@28221|Deltaproteobacteria,2YYAU@29|Myxococcales 28221|Deltaproteobacteria J Ion transport protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans k59_60183_2 1896.JOAU01000017_gene2935 7.25e-21 94.7 COG1028@1|root,COG1028@2|Bacteria,2GNM4@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr yohF - - - - - - - - - - - adh_short_C2 k59_634762_1 1229909.NSED_08390 1.28e-94 284.0 COG0042@1|root,arCOG00604@2157|Archaea 2157|Archaea J Dihydrouridine synthase (Dus) dusA1 - - - - - - - - - - - Dus k59_737521_1 506534.Rhein_3210 0.000234 42.7 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,1WWE2@135613|Chromatiales 135613|Chromatiales G Inositol monophosphatase - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_737521_2 1453501.JELR01000001_gene3028 2.02e-75 236.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,465US@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - 2.1.1.200 ko:K02533,ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_1269415_1 215803.DB30_8661 1.42e-34 134.0 2DMMW@1|root,32SIJ@2|Bacteria,1N004@1224|Proteobacteria,42TSJ@68525|delta/epsilon subdivisions,2WQHG@28221|Deltaproteobacteria,2YV84@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1578978_1 1120949.KB903328_gene9005 4.72e-06 52.4 COG0615@1|root,COG0615@2|Bacteria,2IC88@201174|Actinobacteria 201174|Actinobacteria IM Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3 k59_1317440_2 1469245.JFBG01000061_gene2322 6.98e-85 266.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1WWDG@135613|Chromatiales 135613|Chromatiales E TIGRFAM Acetolactate synthase, large subunit, biosynthetic - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_799677_1 1545915.JROG01000004_gene2275 7.25e-87 271.0 COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,2U0CV@28211|Alphaproteobacteria,2KCQ8@204457|Sphingomonadales 204457|Sphingomonadales I Acyl-CoA dehydrogenase, type 2, C-terminal domain - - 1.14.13.235 ko:K22027 - - - - ko00000,ko01000 - - - Acyl-CoA_dh_2,Acyl-CoA_dh_N k59_586992_1 1968.JOEV01000033_gene8425 1.5e-45 151.0 COG1545@1|root,COG1545@2|Bacteria,2IFQP@201174|Actinobacteria 201174|Actinobacteria S nucleic-acid-binding protein containing a Zn-ribbon - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_1370588_1 1206731.BAGB01000165_gene4381 1.11e-50 175.0 COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,4G06W@85025|Nocardiaceae 201174|Actinobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_116269_1 1235457.C404_29345 4.48e-30 124.0 COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2WGN9@28216|Betaproteobacteria,1K1R2@119060|Burkholderiaceae 28216|Betaproteobacteria S transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_5654_2 378806.STAUR_1477 1.09e-07 52.8 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YWK2@29|Myxococcales 28221|Deltaproteobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_221534_1 56780.SYN_00747 4.84e-15 75.5 COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,42Q9D@68525|delta/epsilon subdivisions,2WK21@28221|Deltaproteobacteria,2MQ4M@213462|Syntrophobacterales 28221|Deltaproteobacteria S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 k59_221534_2 330214.NIDE1094 7.67e-20 100.0 COG0577@1|root,COG0577@2|Bacteria,3J0Z3@40117|Nitrospirae 40117|Nitrospirae V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_116277_1 1247649.D560_1936 5.67e-54 180.0 COG0657@1|root,COG0657@2|Bacteria,1MV3J@1224|Proteobacteria,2VNRV@28216|Betaproteobacteria,3T6HM@506|Alcaligenaceae 28216|Betaproteobacteria I alpha/beta hydrolase fold - - 3.5.1.9 ko:K01432 ko00380,ko00630,ko01100,map00380,map00630,map01100 M00038 R00988,R01959,R04911 RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_3 k59_430295_1 1122611.KB903951_gene6242 6.05e-09 60.1 COG0500@1|root,COG2226@2|Bacteria,2I1C5@201174|Actinobacteria,4EMU5@85012|Streptosporangiales 201174|Actinobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_430295_2 118173.KB235914_gene3902 8.22e-53 174.0 COG1215@1|root,COG1215@2|Bacteria,1G5YB@1117|Cyanobacteria,1HB60@1150|Oscillatoriales 1117|Cyanobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1423950_1 76869.PputGB1_3354 2.43e-37 142.0 COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,1T1HR@1236|Gammaproteobacteria,1YX8A@136845|Pseudomonas putida group 1236|Gammaproteobacteria V Type I secretion system - - - ko:K06148,ko:K12536 ko02010,map02010 M00328 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1,3.A.1.110 - - ABC_membrane,ABC_tran k59_799712_1 518766.Rmar_0695 2.49e-68 218.0 COG0247@1|root,COG0247@2|Bacteria,4NIMP@976|Bacteroidetes 976|Bacteroidetes C Fe-S oxidoreductase - - - ko:K18928 - - - - ko00000 - - - CCG k59_1477484_1 404380.Gbem_3239 5.17e-119 352.0 COG1914@1|root,COG1914@2|Bacteria,1N0XH@1224|Proteobacteria,43B4Q@68525|delta/epsilon subdivisions,2X6IC@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PFAM natural resistance-associated macrophage protein - - - - - - - - - - - - Nramp k59_1423952_1 1297863.APJF01000026_gene3693 6.92e-23 100.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,3JSY1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_587022_1 572477.Alvin_0342 7.32e-87 280.0 COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,1RN89@1236|Gammaproteobacteria,1WWQS@135613|Chromatiales 135613|Chromatiales Q PFAM Mammalian cell entry related - - - ko:K06192 - - - - ko00000 - - - MlaD k59_587022_2 631362.Thi970DRAFT_00762 3.45e-22 97.8 COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,1S576@1236|Gammaproteobacteria,1WYCB@135613|Chromatiales 135613|Chromatiales S ABC-type transport auxiliary lipoprotein component - - - ko:K09857 - - - - ko00000 - - - ABC_trans_aux k59_68152_1 1219035.NT2_10_00620 2.55e-07 55.5 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2U2CJ@28211|Alphaproteobacteria,2KD2X@204457|Sphingomonadales 204457|Sphingomonadales EU COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - - - - - - - - - - PD40,Peptidase_S9 k59_534681_1 395494.Galf_2389 7.65e-46 159.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2VIBJ@28216|Betaproteobacteria,44WDP@713636|Nitrosomonadales 28216|Betaproteobacteria K Transcriptional regulator, LysR family oxyR - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_68160_1 395961.Cyan7425_2241 7.91e-27 112.0 COG1282@1|root,COG1282@2|Bacteria,1G2AX@1117|Cyanobacteria,3KHIK@43988|Cyanothece 1117|Cyanobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_1317457_1 1379701.JPJC01000155_gene2209 2.05e-05 44.7 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2U982@28211|Alphaproteobacteria,2K5BT@204457|Sphingomonadales 204457|Sphingomonadales S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_1317457_2 395493.BegalDRAFT_1677 0.0 1089.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,45ZV1@72273|Thiotrichales 72273|Thiotrichales O ATP-dependent Clp protease ATP-binding subunit ClpA - - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1317457_3 472759.Nhal_3737 4.72e-41 135.0 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,1S8WZ@1236|Gammaproteobacteria,1WZ35@135613|Chromatiales 135613|Chromatiales J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_1317457_4 1122604.JONR01000016_gene4428 3.69e-41 145.0 COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,1RYD7@1236|Gammaproteobacteria,1X3H9@135614|Xanthomonadales 135614|Xanthomonadales O May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ate GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 2.3.2.29 ko:K21420 - - R11547,R11548 RC00064 ko00000,ko01000 - - - ATE_C,ATE_N k59_1109665_1 1479237.JMLY01000001_gene908 4.78e-12 62.8 COG0789@1|root,COG0789@2|Bacteria,1RITY@1224|Proteobacteria,1S61S@1236|Gammaproteobacteria,467B3@72275|Alteromonadaceae 1236|Gammaproteobacteria K Transcriptional regulators liuR - - - - - - - - - - - MerR,MerR-DNA-bind,MerR_1 k59_1109665_2 267608.RSc0237 7.27e-180 537.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,1K4Q5@119060|Burkholderiaceae 28216|Betaproteobacteria EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_430314_1 1122135.KB893166_gene2882 1.6e-40 147.0 COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,2TRA3@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_430314_2 713587.THITH_06930 4.56e-57 199.0 COG0247@1|root,COG0277@1|root,COG1146@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG1146@2|Bacteria,1MU6Y@1224|Proteobacteria,1RM7Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S ferredoxin lldE - - ko:K18930 - - - - ko00000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_7,Fer4_8 k59_1579024_1 1121935.AQXX01000144_gene4308 5.04e-46 171.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C,Acyltransferase,Aminotran_1_2,NAD_binding_4,PP-binding,Thioesterase k59_900724_1 56107.Cylst_1820 5.65e-108 328.0 COG0520@1|root,COG0520@2|Bacteria,1G30B@1117|Cyanobacteria,1HTZW@1161|Nostocales 1117|Cyanobacteria E Cysteine desulfurase - - - - - - - - - - - - Aminotran_5 k59_900724_2 391625.PPSIR1_40710 1.33e-48 166.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria,2Z21X@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the ferrous insertion into protoporphyrin IX hemH GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_1423981_1 1149133.ppKF707_1207 6.41e-29 114.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1S248@1236|Gammaproteobacteria,1YEEP@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M MlaA lipoprotein - - - ko:K04754 - - - - ko00000 - - - MlaA k59_952230_1 323261.Noc_1573 1.05e-29 111.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1WYRM@135613|Chromatiales 135613|Chromatiales O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_952230_2 1353537.TP2_16940 2.72e-23 95.5 COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,2U3PI@28211|Alphaproteobacteria,2XPCM@285107|Thioclava 28211|Alphaproteobacteria C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_68179_1 436308.Nmar_0592 9.64e-106 316.0 COG1060@1|root,arCOG00656@2157|Archaea,41SDT@651137|Thaumarchaeota 651137|Thaumarchaeota H Radical SAM - - 2.5.1.77 ko:K11781 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_587041_1 1535422.ND16A_0424 7.95e-88 273.0 COG2304@1|root,COG2304@2|Bacteria,1R8EZ@1224|Proteobacteria,1SG9K@1236|Gammaproteobacteria,2Q7R9@267889|Colwelliaceae 1236|Gammaproteobacteria S Peptidase M64 N-terminus - - - - - - - - - - - - M64_N,Peptidase_M64 k59_799752_1 926560.KE387023_gene3327 1.32e-30 116.0 COG2062@1|root,COG2062@2|Bacteria,1WN47@1297|Deinococcus-Thermus 2|Bacteria T phosphohistidine phosphatase, SixA - - - - - - - - - - - - His_Phos_1 k59_1579032_1 1121406.JAEX01000033_gene2092 0.000707 43.1 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2M7VB@213115|Desulfovibrionales 28221|Deltaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_642831_1 1229909.NSED_00820 3.4e-78 235.0 arCOG10529@1|root,arCOG10529@2157|Archaea,41SSF@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_642831_2 436308.Nmar_0205 3e-21 85.5 COG0328@1|root,arCOG02942@2157|Archaea,41SWJ@651137|Thaumarchaeota 651137|Thaumarchaeota L RNase H - - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RVT_3 k59_952235_1 1125863.JAFN01000001_gene3121 8.3e-48 164.0 COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,42QQ8@68525|delta/epsilon subdivisions,2WMX3@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1632205_1 1117647.M5M_04115 1.98e-42 147.0 COG2818@1|root,COG2818@2|Bacteria,1R3WB@1224|Proteobacteria,1RSAH@1236|Gammaproteobacteria,1J6AM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG2818 3-methyladenine DNA glycosylase IV02_03670 - - - - - - - - - - - Adenine_glyco k59_1632205_2 1123368.AUIS01000010_gene2379 3.32e-47 155.0 COG2259@1|root,COG2259@2|Bacteria,1MZVP@1224|Proteobacteria,1S8UI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S membrane yqjF - - ko:K15977 - - - - ko00000 - - - DoxX k59_1632205_3 243233.MCA0816 4.59e-43 144.0 COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,1S2N9@1236|Gammaproteobacteria,1XEUU@135618|Methylococcales 135618|Methylococcales F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k59_1269518_1 487521.OCU_19590 2.68e-33 130.0 COG1960@1|root,COG1960@2|Bacteria,2I9CW@201174|Actinobacteria,236QV@1762|Mycobacteriaceae 201174|Actinobacteria I Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1269518_2 1068978.AMETH_2030 1.76e-19 90.5 COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4E28H@85010|Pseudonocardiales 201174|Actinobacteria I Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_693407_1 1210046.B277_07900 8.75e-17 84.7 COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria,4FG1X@85021|Intrasporangiaceae 201174|Actinobacteria Q Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_693407_2 397278.JOJN01000003_gene2122 7.81e-22 94.4 COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,4DPDC@85009|Propionibacteriales 201174|Actinobacteria Q Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_900733_1 713586.KB900536_gene1818 1.7e-193 550.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1WWX1@135613|Chromatiales 135613|Chromatiales C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_900733_2 318167.Sfri_0258 4.09e-124 370.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,2Q8ZR@267890|Shewanellaceae 1236|Gammaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_483895_1 448385.sce2596 8.06e-47 167.0 COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,42YQ0@68525|delta/epsilon subdivisions,2WTRV@28221|Deltaproteobacteria,2YUFX@29|Myxococcales 28221|Deltaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - - k59_1477546_1 1121015.N789_04330 4.65e-05 44.7 COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1S8HN@1236|Gammaproteobacteria,1X62E@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_1477546_2 562970.Btus_0314 7.36e-87 277.0 COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HACS@91061|Bacilli,2790G@186823|Alicyclobacillaceae 91061|Bacilli IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3,6.2.1.48 ko:K00666,ko:K01897,ko:K02182 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_5675_1 1089552.KI911559_gene1440 1.92e-41 144.0 COG2304@1|root,COG2304@2|Bacteria,1RA4S@1224|Proteobacteria,2U5T8@28211|Alphaproteobacteria,2JRP0@204441|Rhodospirillales 204441|Rhodospirillales S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_5675_2 1458275.AZ34_05890 7.43e-26 107.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,4A9UV@80864|Comamonadaceae 28216|Betaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1317481_1 326427.Cagg_1253 7.89e-07 57.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2G790@200795|Chloroflexi,375DF@32061|Chloroflexia 32061|Chloroflexia T SMART protein phosphatase 2C domain protein - - - - - - - - - - - - GAF_2,SpoIIE k59_587063_1 1184607.AUCHE_05_00620 4.83e-40 142.0 COG0638@1|root,COG0638@2|Bacteria,2GKZ1@201174|Actinobacteria,4F6S2@85018|Dermatophilaceae 201174|Actinobacteria O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation prcA GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome k59_953049_2 1244869.H261_01671 6.32e-08 54.3 COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2TUXD@28211|Alphaproteobacteria,2JR87@204441|Rhodospirillales 204441|Rhodospirillales I Enoyl-CoA hydratase/isomerase paaG - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_535460_1 1137799.GZ78_15475 4.42e-09 59.7 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1XHSS@135619|Oceanospirillales 135619|Oceanospirillales V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_535460_2 743721.Psesu_3036 5.43e-26 106.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1X3TB@135614|Xanthomonadales 135614|Xanthomonadales V Transport permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_485286_1 1144312.PMI09_05547 5.28e-44 152.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2TVCY@28211|Alphaproteobacteria,4BCCP@82115|Rhizobiaceae 28211|Alphaproteobacteria O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_485286_2 1158182.KB905024_gene202 0.000175 42.7 COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1WWAM@135613|Chromatiales 135613|Chromatiales H Uroporphyrinogen III synthase - - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 k59_430965_1 522306.CAP2UW1_3214 9.76e-89 271.0 COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2VMA5@28216|Betaproteobacteria 28216|Betaproteobacteria S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - - k59_430965_2 1380394.JADL01000014_gene241 2.87e-09 53.9 COG1977@1|root,COG1977@2|Bacteria,1N9QE@1224|Proteobacteria,2UKCD@28211|Alphaproteobacteria 28211|Alphaproteobacteria H ThiS family - - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - - k59_1005408_1 449447.MAE_22880 6.54e-05 44.7 COG0242@1|root,COG0242@2|Bacteria,1G52N@1117|Cyanobacteria 1117|Cyanobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions - GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_1005408_2 1147.D082_20570 3.38e-55 182.0 COG3588@1|root,COG3588@2|Bacteria,1GIGU@1117|Cyanobacteria,1H6CK@1142|Synechocystis 1117|Cyanobacteria F Fructose-bisphosphate aldolase class-I - - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic k59_485287_1 1304275.C41B8_04481 3.59e-65 225.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_587835_1 47763.JNZA01000031_gene1861 5.16e-16 84.0 COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria 201174|Actinobacteria Q oxidoreductase - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Amino_oxidase,DAO,NAD_binding_8 k59_327351_1 1223544.GSI01S_09_00510 0.000818 48.5 COG0613@1|root,COG0613@2|Bacteria,2GNAP@201174|Actinobacteria,4GB94@85026|Gordoniaceae 201174|Actinobacteria S DNA polymerase alpha chain like domain PPA1328 - 3.1.3.97,3.1.4.57 ko:K07053,ko:K20859 ko00440,map00440 - R00188,R10972,R10973,R11188 RC00078,RC00296 ko00000,ko00001,ko01000 - - - PHP k59_694261_1 713586.KB900536_gene630 3.98e-152 435.0 COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,1RSNX@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives ylbG - - - - - - - - - - - HTH_29,rve,rve_2,rve_3 k59_953056_1 1341151.ASZU01000004_gene118 6.88e-16 79.0 COG1399@1|root,COG1399@2|Bacteria,1VB08@1239|Firmicutes,4HME9@91061|Bacilli,27C62@186824|Thermoactinomycetaceae 91061|Bacilli S Uncharacterized ACR, COG1399 ylbN - - ko:K07040 - - - - ko00000 - - - DUF177 k59_953056_2 1123252.ATZF01000016_gene1671 2.56e-65 213.0 COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,4HBCU@91061|Bacilli,27BCT@186824|Thermoactinomycetaceae 91061|Bacilli I Acyl transferase domain fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_644122_1 13689.BV96_02815 1.12e-33 134.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,2K0R4@204457|Sphingomonadales 204457|Sphingomonadales V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_69475_1 160799.PBOR_26515 4.06e-29 117.0 COG2211@1|root,COG2211@2|Bacteria,1U037@1239|Firmicutes,4HBZK@91061|Bacilli,26YTA@186822|Paenibacillaceae 91061|Bacilli G MFS/sugar transport protein yihO3 - - ko:K03292,ko:K16210 - - - - ko00000,ko02000 2.A.2,2.A.2.5 - - MFS_2 k59_1579882_1 93220.LV28_22925 7.92e-58 189.0 COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,2VS13@28216|Betaproteobacteria,1JZZC@119060|Burkholderiaceae 28216|Betaproteobacteria G Phosphoglycolate phosphatase gph - 3.1.3.105 ko:K22292 ko00520,map00520 - R11785 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_333132_1 1232410.KI421426_gene1403 3.1e-60 193.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,42NC0@68525|delta/epsilon subdivisions,2WJK9@28221|Deltaproteobacteria,43TEV@69541|Desulfuromonadales 28221|Deltaproteobacteria G Ribulose-phosphate 3 epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_700034_1 1469245.JFBG01000096_gene1300 1.08e-89 273.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1WWSB@135613|Chromatiales 135613|Chromatiales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_907398_1 344747.PM8797T_00127 3.01e-57 185.0 COG0426@1|root,COG0426@2|Bacteria,2J1SN@203682|Planctomycetes 203682|Planctomycetes C domain, Protein - - - - - - - - - - - - - k59_1116215_1 1123355.JHYO01000012_gene753 1.93e-20 91.3 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,36XEY@31993|Methylocystaceae 28211|Alphaproteobacteria L Helix-hairpin-helix class 2 (Pol1 family) motifs polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1116215_2 857087.Metme_4198 9.84e-52 169.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria,1XETV@135618|Methylococcales 135618|Methylococcales E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_1064291_1 1229909.NSED_02630 1.9e-101 303.0 COG1064@1|root,arCOG01455@2157|Archaea,41SA9@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1432483_1 1267535.KB906767_gene5238 8.78e-14 74.3 2DZX2@1|root,32VM6@2|Bacteria,3Y88Y@57723|Acidobacteria 57723|Acidobacteria - - - - - - - - - - - - - - - k59_387332_1 1283300.ATXB01000001_gene1274 3.9e-99 306.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1XDT5@135618|Methylococcales 135618|Methylococcales EGP PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_1527789_1 330214.NIDE3081 1.9e-128 368.0 COG3253@1|root,COG3253@2|Bacteria 2|Bacteria S peroxidase activity - - - - - - - - - - - - Chlor_dismutase k59_124974_1 335543.Sfum_2726 3.4e-142 416.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,42MZN@68525|delta/epsilon subdivisions,2WJGK@28221|Deltaproteobacteria,2MQ6X@213462|Syntrophobacterales 28221|Deltaproteobacteria S Belongs to the RtcB family rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_124974_2 338966.Ppro_2143 1.25e-13 69.7 COG1371@1|root,COG1371@2|Bacteria,1NMZF@1224|Proteobacteria,42X9A@68525|delta/epsilon subdivisions,2WSP3@28221|Deltaproteobacteria,43V4V@69541|Desulfuromonadales 28221|Deltaproteobacteria S Archease protein family (MTH1598/TM1083) - - - - - - - - - - - - Archease k59_541023_1 1229909.NSED_03665 2.39e-13 64.7 COG1522@1|root,arCOG01117@2157|Archaea 2157|Archaea K COG1522 Transcriptional regulators - - - - - - - - - - - - AsnC_trans_reg k59_437845_2 754038.G8EXY8_9CAUD 2.25e-07 53.1 4QD8M@10239|Viruses,4QZGV@35237|dsDNA viruses no RNA stage,4QU5A@28883|Caudovirales,4QJQD@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1486181_1 1121374.KB891575_gene1044 5.54e-27 112.0 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,1RXYY@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q cytochrome p450 - - - - - - - - - - - - p450 k59_8593_1 521674.Plim_4204 8.1e-107 332.0 COG0441@1|root,COG0441@2|Bacteria,2IXFR@203682|Planctomycetes 203682|Planctomycetes J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_1527803_1 1123514.KB905899_gene1078 3.04e-62 216.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,463KB@72273|Thiotrichales 72273|Thiotrichales M PFAM Transglycosylase SLT domain - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_1527803_2 243159.AFE_0963 1.26e-30 117.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,2NCGY@225057|Acidithiobacillales 225057|Acidithiobacillales GM Saccharopine dehydrogenase NADP binding domain - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Epimerase,NAD_binding_10 k59_1223869_1 755178.Cyan10605_1379 4.65e-41 149.0 COG0803@1|root,COG0803@2|Bacteria,1G04M@1117|Cyanobacteria 1117|Cyanobacteria P Belongs to the bacterial solute-binding protein 9 family zntC - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_808624_1 1415778.JQMM01000001_gene300 1.79e-80 248.0 COG1073@1|root,COG1073@2|Bacteria,1PES1@1224|Proteobacteria,1RXGI@1236|Gammaproteobacteria,1JBFG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Serine aminopeptidase, S33 - - - - - - - - - - - - Hydrolase_4 k59_492594_1 436308.Nmar_1794 6.19e-120 373.0 COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC - 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - PolC_DP2 k59_855084_1 1163398.AJJP01000039_gene3094 5.32e-29 123.0 COG4191@1|root,COG4191@2|Bacteria,1RF3G@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4 k59_1223879_1 1229909.NSED_08495 1.13e-66 211.0 arCOG08035@1|root,arCOG08035@2157|Archaea,41SQD@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_437884_1 1278078.G419_10587 3.33e-05 46.6 COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,4G06W@85025|Nocardiaceae 201174|Actinobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_437884_2 1160137.KB907307_gene601 8.69e-12 67.0 COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4G061@85025|Nocardiaceae 201174|Actinobacteria C Alcohol dehydrogenase GroES-like domain - - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_855087_1 331869.BAL199_25634 5.45e-56 188.0 COG0477@1|root,COG2814@2|Bacteria,1QW9T@1224|Proteobacteria,2TY4I@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1223893_1 1191523.MROS_0163 4.86e-07 50.4 COG0121@1|root,COG0121@2|Bacteria 2|Bacteria S cellular modified histidine biosynthetic process - - - - - - - - - - - - GATase_4 k59_1223893_2 1191523.MROS_0164 1.13e-69 220.0 COG0002@1|root,COG0002@2|Bacteria 2|Bacteria E N-acetyl-gamma-glutamyl-phosphate reductase activity argC - 1.2.1.38 ko:K00145,ko:K05829 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00028,M00031,M00763,M00845 R03443,R09777,R10931 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_437892_1 118163.Ple7327_1614 3.55e-37 139.0 COG2159@1|root,COG2159@2|Bacteria,1G3DV@1117|Cyanobacteria,3VKKA@52604|Pleurocapsales 1117|Cyanobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1322306_1 663610.JQKO01000015_gene1906 0.000116 51.2 COG0642@1|root,COG2972@1|root,COG2205@2|Bacteria,COG2972@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria,3N9SQ@45404|Beijerinckiaceae 28211|Alphaproteobacteria T GAF domain - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,Response_reg,dCache_1 k59_958617_1 641526.ADIWIN_2498 1e-10 65.9 COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,1HYE4@117743|Flavobacteriia 976|Bacteroidetes T Universal stress protein - - - - - - - - - - - - Usp k59_958617_2 266117.Rxyl_1013 1.51e-11 65.9 COG0517@1|root,COG4747@1|root,COG0517@2|Bacteria,COG4747@2|Bacteria,2GSAR@201174|Actinobacteria 201174|Actinobacteria S Cbs domain - - - ko:K04767 - - - - ko00000 - - - ACT,CBS k59_855108_1 1206741.BAFX01000050_gene2228 3.55e-25 102.0 COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4FXVR@85025|Nocardiaceae 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_855108_2 1169152.AXVD01000014_gene1447 1.57e-40 142.0 COG5285@1|root,COG5285@2|Bacteria,2GNXP@201174|Actinobacteria,4FVHP@85025|Nocardiaceae 201174|Actinobacteria Q Phytanoyl-CoA dioxygenase (PhyH) - - - - - - - - - - - - PhyH k59_280758_1 404380.Gbem_2125 1.82e-45 165.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_808670_1 237368.SCABRO_02754 7.58e-101 310.0 COG0439@1|root,COG0439@2|Bacteria,2J2A6@203682|Planctomycetes 203682|Planctomycetes I Biotin carboxylase - - - - - - - - - - - - - k59_751171_1 1408452.JAGZ01000001_gene3619 1.85e-32 126.0 COG4799@1|root,COG4799@2|Bacteria,2GNV2@201174|Actinobacteria,233IQ@1762|Mycobacteriaceae 201174|Actinobacteria I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) accD4_2 - - - - - - - - - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans k59_751171_2 1299327.I546_1260 2.08e-39 150.0 COG3011@1|root,COG3011@2|Bacteria,2GMSU@201174|Actinobacteria,232YP@1762|Mycobacteriaceae 201174|Actinobacteria S Lipase maturation factor LMF - - - - - - - - - - - LMF1 k59_1012362_1 671143.DAMO_1019 8.33e-103 311.0 COG1488@1|root,COG1488@2|Bacteria,2NNUE@2323|unclassified Bacteria 2|Bacteria H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP pncB GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - iYO844.BSU31750 NAPRTase k59_1640728_2 316067.Geob_3460 5.68e-14 72.8 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,42N50@68525|delta/epsilon subdivisions,2WJ23@28221|Deltaproteobacteria,43TM9@69541|Desulfuromonadales 28221|Deltaproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_541934_1 1229909.NSED_01445 2.46e-144 419.0 COG0036@1|root,COG3959@1|root,arCOG01053@2157|Archaea,arCOG05046@2157|Archaea,41SBE@651137|Thaumarchaeota 651137|Thaumarchaeota G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim,Transketolase_N k59_541936_2 460265.Mnod_7260 4.21e-10 62.4 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2TRNR@28211|Alphaproteobacteria,1JS0D@119045|Methylobacteriaceae 28211|Alphaproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_701104_1 641147.HMPREF9021_00346 4.83e-17 79.0 COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,2VRU5@28216|Betaproteobacteria,2KR33@206351|Neisseriales 206351|Neisseriales L Psort location Cytoplasmic, score 8.96 mutT - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_701104_2 32049.SYNPCC7002_A2455 2.82e-23 95.9 COG0177@1|root,COG0177@2|Bacteria,1G1VI@1117|Cyanobacteria,1GYMC@1129|Synechococcus 1117|Cyanobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_281692_1 444860.E3SIW4_9CAUD 5.88e-59 191.0 4QFU0@10239|Viruses,4QW3E@35237|dsDNA viruses no RNA stage,4QUG7@28883|Caudovirales,4QI5N@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_388620_1 1144672.F966_00451 1.01e-101 309.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,3NKKZ@468|Moraxellaceae 1236|Gammaproteobacteria M Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_228935_1 1157708.KB907460_gene1497 2.43e-13 70.1 COG4177@1|root,COG4177@2|Bacteria,1MU52@1224|Proteobacteria,2VIFR@28216|Betaproteobacteria,4AHPH@80864|Comamonadaceae 28216|Betaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_228935_2 177437.HRM2_21310 2.45e-60 196.0 COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,42QV6@68525|delta/epsilon subdivisions,2WMN1@28221|Deltaproteobacteria,2MK1Y@213118|Desulfobacterales 28221|Deltaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_959496_2 1268622.AVS7_04317 1.71e-34 124.0 COG5553@1|root,COG5553@2|Bacteria,1RD6A@1224|Proteobacteria 1224|Proteobacteria S of the double-stranded beta helix - - - - - - - - - - - - CDO_I k59_653134_2 1117647.M5M_04585 6.04e-09 60.1 2EDVS@1|root,337QX@2|Bacteria,1NEZW@1224|Proteobacteria,1SCKV@1236|Gammaproteobacteria,1J6US@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_653136_1 1121937.AUHJ01000041_gene283 5.32e-125 366.0 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,1RN81@1236|Gammaproteobacteria,46AFS@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG0183 Acetyl-CoA acetyltransferase - - - - - - - - - - - - Thiolase_C k59_1640781_1 330214.NIDE0981 1.09e-44 156.0 COG0141@1|root,COG0141@2|Bacteria,3J0C6@40117|Nitrospirae 40117|Nitrospirae E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_1640781_2 1260251.SPISAL_06935 3.31e-08 55.8 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1WX3P@135613|Chromatiales 135613|Chromatiales E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG k59_1377916_1 1229909.NSED_03465 1.87e-87 264.0 COG0517@1|root,arCOG00600@2157|Archaea 2157|Archaea K CBS domain - - - ko:K07182 - - - - ko00000 - - - CBS k59_594683_1 323261.Noc_2775 1.91e-118 352.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RSN1@1236|Gammaproteobacteria,1WVUQ@135613|Chromatiales 135613|Chromatiales I PFAM Fatty acid desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - DDE_Tnp_ISL3,FA_desaturase k59_594683_2 398527.Bphyt_4727 9.2e-31 118.0 COG4360@1|root,COG4360@2|Bacteria,1RDRJ@1224|Proteobacteria,2VSAU@28216|Betaproteobacteria,1K35M@119060|Burkholderiaceae 28216|Betaproteobacteria F ATP adenylyltransferase - - 2.7.7.53 ko:K00988 ko00230,map00230 - R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 - - - ATP_transf k59_1117226_1 1280663.ATVR01000046_gene3114 3.77e-10 67.4 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,248CS@186801|Clostridia,4BWC0@830|Butyrivibrio 186801|Clostridia JK Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_78492_1 1206726.BAFV01000123_gene6296 1.19e-73 236.0 COG1902@1|root,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,4FUWR@85025|Nocardiaceae 201174|Actinobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - 1.8.1.20 ko:K22347 - - - - ko00000,ko01000 - - - Oxidored_FMN k59_494366_1 1095769.CAHF01000006_gene1729 1.04e-32 129.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,4725A@75682|Oxalobacteraceae 28216|Betaproteobacteria V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA - - ko:K02021,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran k59_78494_1 1040989.AWZU01000002_gene5372 4.19e-14 74.7 28Q4W@1|root,2ZCMZ@2|Bacteria,1MX8J@1224|Proteobacteria,2U0AB@28211|Alphaproteobacteria,3JWYS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_541971_1 1219035.NT2_02_05790 2.16e-57 188.0 COG1028@1|root,COG1028@2|Bacteria,1MXQR@1224|Proteobacteria,2TW65@28211|Alphaproteobacteria,2K37A@204457|Sphingomonadales 204457|Sphingomonadales IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_541971_2 2850.Phatr35638 4.45e-09 63.2 COG0673@1|root,KOG2742@2759|Eukaryota 2759|Eukaryota J oxidoreductase activity - - - - - - - - - - - - GFO_IDH_MocA k59_1117229_1 171693.BN988_00492 6.53e-47 164.0 COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,4HA0H@91061|Bacilli,23JF1@182709|Oceanobacillus 91061|Bacilli E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_388645_1 1278073.MYSTI_06394 1.43e-26 108.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,2YU3X@29|Myxococcales 28221|Deltaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_388645_2 246197.MXAN_1995 1.69e-68 223.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ28@28221|Deltaproteobacteria,2YWA0@29|Myxococcales 28221|Deltaproteobacteria NU Type II/IV secretion system protein pilT-1 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1640816_1 702113.PP1Y_AT11532 4.97e-65 206.0 COG0625@1|root,COG0625@2|Bacteria,1R6UY@1224|Proteobacteria,2UPFV@28211|Alphaproteobacteria,2K9KE@204457|Sphingomonadales 204457|Sphingomonadales O Glutathione S-transferase, C-terminal domain - - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_N_3 k59_126013_2 671143.DAMO_0883 1e-21 91.7 COG0491@1|root,COG0491@2|Bacteria,2NPD5@2323|unclassified Bacteria 2|Bacteria S Metallo-beta-lactamase superfamily pksB GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006090,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019184,GO:0019752,GO:0031974,GO:0032787,GO:0034641,GO:0042398,GO:0043043,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051186,GO:0051188,GO:0070013,GO:0071704,GO:1901564,GO:1901566,GO:1901576 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B k59_438831_1 1548153.LR59_12515 5.56e-64 209.0 COG1060@1|root,COG1060@2|Bacteria,1QN23@1224|Proteobacteria,42M6Z@68525|delta/epsilon subdivisions,2YMA7@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria H Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate mqnE - 2.5.1.120 ko:K18285 ko00130,ko01110,map00130,map01110 - R10667 RC00021,RC03234 ko00000,ko00001,ko01000 - - - Radical_SAM k59_173803_1 1121405.dsmv_3570 2.62e-61 200.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria,2MHM9@213118|Desulfobacterales 28221|Deltaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_1434155_1 246197.MXAN_5942 1.76e-85 259.0 COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,42PY3@68525|delta/epsilon subdivisions,2WISK@28221|Deltaproteobacteria,2YXF7@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_1434155_2 1247726.MIM_c32650 2.76e-40 140.0 COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2VSH8@28216|Betaproteobacteria,3T3VD@506|Alcaligenaceae 28216|Betaproteobacteria H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis folA - 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 - - - DHFR_1 k59_758105_1 756272.Plabr_4510 2.38e-12 72.4 COG1807@1|root,COG1807@2|Bacteria,2IZ8J@203682|Planctomycetes 203682|Planctomycetes M glycosyl transferase family 39 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2,PMT_2 k59_179551_1 265072.Mfla_1701 6.89e-25 108.0 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,2KMD2@206350|Nitrosomonadales 206350|Nitrosomonadales NU pilus assembly protein FimV - - - ko:K08086 - - - - ko00000 - - - - k59_87603_1 436308.Nmar_1055 9.52e-127 372.0 COG1530@1|root,arCOG00321@2157|Archaea,41T2C@651137|Thaumarchaeota 651137|Thaumarchaeota L modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1233528_1 161528.ED21_19817 8.27e-44 154.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TR4J@28211|Alphaproteobacteria,2K0GH@204457|Sphingomonadales 204457|Sphingomonadales C Electron transfer flavoprotein - - - ko:K03521 - - - - ko00000 - - - ETF k59_1442920_1 35128.Thapsdraft977 9.48e-32 112.0 COG0199@1|root,KOG1741@2759|Eukaryota,2XGBA@2836|Bacillariophyta 2836|Bacillariophyta J Binds 16S rRNA, required for the assembly of 30S particles - GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009536,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_1442920_2 35128.Thapsdraft1720 1.43e-28 113.0 COG0465@1|root,KOG0731@2759|Eukaryota,2XEEJ@2836|Bacillariophyta 2836|Bacillariophyta O Acts as a processive, ATP-dependent zinc metallopeptidase - - - - - - - - - - - - AAA,Peptidase_M41 k59_707956_1 113395.AXAI01000002_gene5230 1.76e-10 60.8 COG0391@1|root,COG0391@2|Bacteria,1NK78@1224|Proteobacteria,2TUUA@28211|Alphaproteobacteria,3JX46@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Uncharacterised protein family UPF0052 cofD - 2.7.8.28 ko:K11212 ko00680,ko01120,map00680,map01120 M00378 R09398 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - UPF0052 k59_707956_2 1348657.M622_04990 4.85e-48 162.0 COG1478@1|root,COG1478@2|Bacteria,1PQHN@1224|Proteobacteria,2VS0K@28216|Betaproteobacteria,2KYP2@206389|Rhodocyclales 206389|Rhodocyclales S F420-0:Gamma-glutamyl ligase - - 6.3.2.31,6.3.2.34 ko:K12234 ko00680,ko01120,map00680,map01120 M00378 R09399,R09400 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000 - - - F420_ligase k59_1289727_2 1156919.QWC_12898 1.58e-27 107.0 COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2VVPX@28216|Betaproteobacteria,3T4FJ@506|Alcaligenaceae 28216|Betaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation tatB - - ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_1497211_1 391615.ABSJ01000027_gene193 9.56e-88 275.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria,1J4QJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EQ Hydantoinase B/oxoprolinase hyuB - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_1497211_2 555778.Hneap_1149 4.98e-46 150.0 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,1WYMA@135613|Chromatiales 135613|Chromatiales O Belongs to the glutaredoxin family. Monothiol subfamily - - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin k59_1289729_2 981369.JQMJ01000004_gene2027 9.93e-54 176.0 COG0299@1|root,COG0299@2|Bacteria,2IGFU@201174|Actinobacteria,2NI7N@228398|Streptacidiphilus 201174|Actinobacteria F Formyl transferase - - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_1650514_1 330214.NIDE3284 8.78e-65 221.0 COG3829@1|root,COG4191@1|root,COG5000@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,3J117@40117|Nitrospirae 40117|Nitrospirae T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - DUF3365,HAMP,HATPase_c,HisKA,PAS_4 k59_179568_1 1449069.JMLO01000008_gene3495 1.26e-27 109.0 COG0451@1|root,COG0451@2|Bacteria,2GN2J@201174|Actinobacteria,4FZ35@85025|Nocardiaceae 201174|Actinobacteria GM Male sterility protein - - - - - - - - - - - - Epimerase,NAD_binding_10 k59_179568_2 1206735.BAGG01000261_gene6544 3.09e-138 412.0 COG4548@1|root,COG4548@2|Bacteria,2GIYK@201174|Actinobacteria,4FYZ0@85025|Nocardiaceae 201174|Actinobacteria P von Willebrand factor (vWF) type A domain - - - - - - - - - - - - VWA,VWA_2 k59_1172673_1 1469245.JFBG01000036_gene1989 8.15e-43 148.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1WWZU@135613|Chromatiales 135613|Chromatiales M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_1126094_1 1226994.AMZB01000084_gene338 9.57e-76 247.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1YF1J@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_917391_1 1196322.A370_05228 1.07e-62 203.0 COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,36EJD@31979|Clostridiaceae 186801|Clostridia E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1126104_1 1121374.KB891575_gene796 1.29e-47 169.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1233 Phytoene dehydrogenase and related proteins crtI - 1.14.99.44,1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027,ko:K10210 ko00906,ko01100,ko01110,map00906,map01100,map01110 - R04787,R04798,R04800,R07654,R09671,R09691,R09692,R09727,R09728 RC00254,RC01214,RC02088,RC02089,RC02605,RC02626,RC02638 ko00000,ko00001,ko01000 - - - Amino_oxidase k59_708966_1 1038859.AXAU01000028_gene24 4.26e-87 264.0 COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2TTC6@28211|Alphaproteobacteria,3JSJ8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_448482_1 243233.MCA0982 4.67e-17 81.6 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1XFEK@135618|Methylococcales 135618|Methylococcales O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_664105_1 177437.HRM2_00460 6.04e-22 100.0 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2MIM9@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - DUF3347,HlyD_D23 k59_1074032_1 861299.J421_3759 7.95e-08 53.5 COG2884@1|root,COG2884@2|Bacteria,1ZTHQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes D ABC transporter - - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_967636_1 1123267.JONN01000001_gene1855 3.07e-64 213.0 COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2TSHG@28211|Alphaproteobacteria,2K1R5@204457|Sphingomonadales 204457|Sphingomonadales S ABC1 family - - - - - - - - - - - - ABC1 k59_1443826_1 292459.STH2936 2.71e-44 161.0 COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia 186801|Clostridia M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_1443826_2 656519.Halsa_2168 8.94e-26 106.0 COG3457@1|root,COG3457@2|Bacteria,1TNYJ@1239|Firmicutes,248MC@186801|Clostridia,3WAHN@53433|Halanaerobiales 186801|Clostridia E PFAM Alanine racemase, N-terminal domain - - 5.1.1.12 ko:K21898 ko00472,map00472 - R00672 RC00302 ko00000,ko00001,ko01000 - - - Ala_racemase_N k59_1594790_1 1304878.AUGD01000007_gene5719 4.9e-44 158.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VFW2@28211|Alphaproteobacteria,3JTF9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus MA20_16675 - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1,PhaC_N k59_1291126_1 330214.NIDE0001 2.81e-53 179.0 COG0593@1|root,COG0593@2|Bacteria,3J0FQ@40117|Nitrospirae 40117|Nitrospirae L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_1291126_2 330214.NIDE0002 6.23e-117 344.0 COG0592@1|root,COG0592@2|Bacteria,3J0RU@40117|Nitrospirae 40117|Nitrospirae L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_1329911_1 394221.Mmar10_0351 3.24e-90 282.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,43Z43@69657|Hyphomonadaceae 28211|Alphaproteobacteria C pyruvate flavodoxin ferredoxin oxidoreductase MA20_01045 - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1173571_1 547163.BN979_05594 7.67e-10 59.7 COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,232NT@1762|Mycobacteriaceae 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1173571_2 1206720.BAFQ01000293_gene6383 8.85e-114 334.0 COG1024@1|root,COG1024@2|Bacteria,2GJ1A@201174|Actinobacteria,4FUZE@85025|Nocardiaceae 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_967640_2 571166.KI421509_gene2107 6.77e-76 247.0 COG0265@1|root,COG1716@1|root,COG0265@2|Bacteria,COG1716@2|Bacteria,1NT6K@1224|Proteobacteria,2UPAI@28211|Alphaproteobacteria 28211|Alphaproteobacteria OT Trypsin-like peptidase domain - - - - - - - - - - - - Trypsin_2 k59_1173574_1 483219.LILAB_05845 4.66e-46 164.0 COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1MXA1@1224|Proteobacteria,42UI3@68525|delta/epsilon subdivisions,2WQ1V@28221|Deltaproteobacteria,2YVFQ@29|Myxococcales 28221|Deltaproteobacteria P Substrate binding domain of ABC-type glycine betaine transport system - - - ko:K05845,ko:K05846 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1,OpuAC k59_236904_1 1267534.KB906758_gene2541 2.87e-05 50.1 COG2911@1|root,COG3391@1|root,COG4625@1|root,COG4934@1|root,COG2911@2|Bacteria,COG3391@2|Bacteria,COG4625@2|Bacteria,COG4934@2|Bacteria,3Y49I@57723|Acidobacteria 57723|Acidobacteria N Bacterial Ig-like domain (group 3) - - - - - - - - - - - - Big_3_5,VCBS k59_917440_1 502025.Hoch_1982 1.11e-40 138.0 COG1978@1|root,COG1978@2|Bacteria 2|Bacteria S oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor prdB - 1.21.4.1,1.21.4.2 ko:K10672,ko:K10794 ko00330,map00330 - R02825 RC00790 ko00000,ko00001,ko01000 - - - GRDB k59_1443841_1 1249627.D779_1583 1.03e-53 181.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1WX4Z@135613|Chromatiales 135613|Chromatiales S AI-2E family transporter - - - ko:K03548 - - - - ko00000,ko02000 2.A.86.1 - - AI-2E_transport k59_180419_1 269799.Gmet_0183 1.12e-66 206.0 COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,42RE8@68525|delta/epsilon subdivisions,2WNA5@28221|Deltaproteobacteria,43U3S@69541|Desulfuromonadales 28221|Deltaproteobacteria O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - AhpC-TSA,Redoxin k59_1126146_2 1137799.GZ78_00330 3.58e-36 134.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RTA0@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - - - - - - - - - - Oxidored_FMN k59_236913_1 861299.J421_3812 2.27e-83 270.0 COG0296@1|root,COG0296@2|Bacteria,1ZT8Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_180425_1 344747.PM8797T_10149 5.87e-33 130.0 COG1914@1|root,COG1914@2|Bacteria 2|Bacteria P metal ion transmembrane transporter activity - - - - - - - - - - - - - k59_395336_1 330214.NIDE0764 6.62e-120 352.0 COG1181@1|root,COG1181@2|Bacteria,3J0JM@40117|Nitrospirae 40117|Nitrospirae F Cell wall formation ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_709001_1 1185653.A1A1_09471 2.34e-23 102.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,4HB60@91061|Bacilli,26D1A@186818|Planococcaceae 91061|Bacilli K Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k59_1535354_1 1168034.FH5T_04765 6.83e-91 276.0 COG0253@1|root,COG0253@2|Bacteria,4NF26@976|Bacteroidetes,2FNI4@200643|Bacteroidia 976|Bacteroidetes E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_342816_1 247156.NFA_7310 1.21e-71 233.0 COG3250@1|root,COG3250@2|Bacteria,2I952@201174|Actinobacteria,4FUJ0@85025|Nocardiaceae 201174|Actinobacteria G Protein of unknown function (DUF2804) - - - - - - - - - - - - DUF2804 k59_1329938_1 436308.Nmar_0392 7.07e-116 344.0 COG1866@1|root,arCOG06073@2157|Archaea,41SE5@651137|Thaumarchaeota 651137|Thaumarchaeota C Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_1535355_1 362976.HQ_1182A 1.29e-26 109.0 COG0667@1|root,arCOG01623@2157|Archaea,2XT87@28890|Euryarchaeota,23SEA@183963|Halobacteria 183963|Halobacteria C oxidoreductases (related to aryl-alcohol dehydrogenases) - - - - - - - - - - - - Aldo_ket_red k59_967670_1 398512.JQKC01000040_gene4102 3.56e-15 72.4 COG0758@1|root,COG0758@2|Bacteria,1VNFT@1239|Firmicutes,24S79@186801|Clostridia,3WMKC@541000|Ruminococcaceae 186801|Clostridia LU Protein of unknown function (DUF2493) - - - - - - - - - - - - DUF2493 k59_1535358_1 472759.Nhal_2669 1.33e-80 249.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNN9@1236|Gammaproteobacteria,1WWN7@135613|Chromatiales 135613|Chromatiales OU PFAM peptidase - - - ko:K04774 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49,Peptidase_S49_N k59_1498687_1 1382359.JIAL01000001_gene96 3.73e-82 258.0 COG1282@1|root,COG1282@2|Bacteria,3Y42H@57723|Acidobacteria,2JM1F@204432|Acidobacteriia 204432|Acidobacteriia C NAD(P) transhydrogenase beta subunit - - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_664163_1 945713.IALB_2282 8.33e-11 61.6 COG0347@1|root,COG0347@2|Bacteria 2|Bacteria K Belongs to the P(II) protein family - - - ko:K04751,ko:K04752 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_759102_1 697282.Mettu_2546 2.76e-35 135.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1XE3Z@135618|Methylococcales 135618|Methylococcales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_759102_2 930169.B5T_00158 1.09e-26 100.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1XJX9@135619|Oceanospirillales 135619|Oceanospirillales J endoribonuclease - - - - - - - - - - - - Ribonuc_L-PSP k59_135711_1 330214.NIDE0993 3.37e-49 165.0 COG0501@1|root,COG0501@2|Bacteria 2|Bacteria O metalloendopeptidase activity - - - - - - - - - - - - Peptidase_M48 k59_1443868_1 468556.AQYG01000048_gene620 2.99e-80 254.0 COG1249@1|root,COG1249@2|Bacteria,2GPG1@201174|Actinobacteria,4GC9W@85026|Gordoniaceae 201174|Actinobacteria C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain sthA - 1.6.1.1 ko:K00322 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_917495_1 1167006.UWK_00099 9.23e-38 144.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WIJY@28221|Deltaproteobacteria,2MHT0@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM ABC transporter - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_505250_1 1123514.KB905899_gene1224 2.65e-26 113.0 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria 1236|Gammaproteobacteria M protein conserved in bacteria - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_135716_1 1266925.JHVX01000003_gene564 2.43e-63 204.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2VJD7@28216|Betaproteobacteria,371N5@32003|Nitrosomonadales 28216|Betaproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_135716_2 1500897.JQNA01000002_gene3799 9.95e-27 110.0 COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2VI8S@28216|Betaproteobacteria,1K0C0@119060|Burkholderiaceae 28216|Betaproteobacteria G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate prpB - 5.4.2.9 ko:K01841 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 - R00661 RC02792 ko00000,ko00001,ko01000 - - - PEP_mutase k59_664183_1 290397.Adeh_0507 1.03e-48 169.0 COG3380@1|root,COG3380@2|Bacteria,1R5C0@1224|Proteobacteria,435D1@68525|delta/epsilon subdivisions,2X984@28221|Deltaproteobacteria,2Z2IU@29|Myxococcales 28221|Deltaproteobacteria S Flavin containing amine oxidoreductase - - - ko:K06955 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 k59_709032_1 1121403.AUCV01000001_gene823 6.8e-57 186.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,43731@68525|delta/epsilon subdivisions,2WKPB@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_1535373_1 743974.MBO_09618 3.82e-06 54.7 COG0668@1|root,COG0668@2|Bacteria,1MXH4@1224|Proteobacteria,1RQHV@1236|Gammaproteobacteria,3NIMC@468|Moraxellaceae 1236|Gammaproteobacteria M Conserved TM helix - - - - - - - - - - - - TM_helix k59_1594842_1 1463936.JOJI01000012_gene6307 7.05e-69 218.0 COG1788@1|root,COG1788@2|Bacteria,2GK61@201174|Actinobacteria 201174|Actinobacteria I coenzyme A transferase cotA - 2.8.3.12 ko:K01039 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_1594842_2 981369.JQMJ01000003_gene7298 3.03e-21 90.1 COG2057@1|root,COG2057@2|Bacteria,2GMA1@201174|Actinobacteria,2NGHS@228398|Streptacidiphilus 201174|Actinobacteria I Coenzyme A transferase - - - - - - - - - - - - CoA_trans k59_1443882_1 331869.BAL199_23497 3.73e-38 142.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2TS6F@28211|Alphaproteobacteria,4BPC1@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_602616_1 765420.OSCT_0585 1.11e-50 171.0 COG0325@1|root,COG0325@2|Bacteria,2G6F1@200795|Chloroflexi,375I2@32061|Chloroflexia 32061|Chloroflexia S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_1020353_1 278957.ABEA03000130_gene1701 8.88e-50 178.0 COG0464@1|root,COG0464@2|Bacteria 2|Bacteria O ATPase activity ycf46 - 3.6.4.6 ko:K06027 ko04138,ko04721,ko04727,ko04962,map04138,map04721,map04727,map04962 - - - ko00000,ko00001,ko01000,ko04131 1.F.1.1 - - AAA k59_602618_1 63737.Npun_F2141 1.4e-80 258.0 COG1136@1|root,COG2203@1|root,COG1136@2|Bacteria,COG2203@2|Bacteria,1G1SM@1117|Cyanobacteria,1HQHA@1161|Nostocales 1117|Cyanobacteria TV GAF modulated ABC exporter, ATPase subunit, DevA family - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,GAF k59_290672_1 309801.trd_1931 2.94e-241 694.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G86T@200795|Chloroflexi,27XQK@189775|Thermomicrobia 189775|Thermomicrobia G Alpha-amylase domain - - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - APH,Alpha-amylase,Malt_amylase_C k59_505292_1 1117319.PSPO_17031 2.33e-59 203.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,1RNUB@1236|Gammaproteobacteria,2Q1VN@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Mechanosensitive ion channel ynaI - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_89167_1 382464.ABSI01000010_gene3668 3.45e-76 244.0 COG0843@1|root,COG0843@2|Bacteria,46S4Q@74201|Verrucomicrobia,2ITKY@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 k59_395390_1 225849.swp_0941 1.31e-32 121.0 COG1863@1|root,COG1863@2|Bacteria,1MZYJ@1224|Proteobacteria,1S7Z3@1236|Gammaproteobacteria,2QBMS@267890|Shewanellaceae 1236|Gammaproteobacteria P PFAM cation antiporter mnhE - - ko:K05569 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MNHE k59_395390_2 998674.ATTE01000001_gene739 2.26e-07 49.7 COG2212@1|root,COG2212@2|Bacteria,1N6VV@1224|Proteobacteria,1SE40@1236|Gammaproteobacteria,462U9@72273|Thiotrichales 72273|Thiotrichales P Multiple resistance and pH regulation protein F (MrpF / PhaF) - - - ko:K05570 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MrpF_PhaF k59_135765_1 883080.HMPREF9697_01616 1.77e-48 159.0 COG0607@1|root,COG0607@2|Bacteria,1RHQZ@1224|Proteobacteria,2U9DZ@28211|Alphaproteobacteria,3JY2J@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Rhodanese Homology Domain MA20_01310 - - - - - - - - - - - Rhodanese k59_1245314_2 243164.DET1333 1.81e-06 50.8 COG1030@1|root,COG1030@2|Bacteria,2GAU7@200795|Chloroflexi,34DCY@301297|Dehalococcoidia 301297|Dehalococcoidia O NfeD-like C-terminal, partner-binding - - - - - - - - - - - - NfeD k59_1512429_2 444861.E3SPQ4_9CAUD 8.71e-41 140.0 4QDP3@10239|Viruses,4QUNG@35237|dsDNA viruses no RNA stage,4QTD6@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1512429_4 268746.Q58MF2_BPPRM 8.44e-67 204.0 4QC29@10239|Viruses,4QX79@35237|dsDNA viruses no RNA stage,4QS3U@28883|Caudovirales,4QJZT@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_100625_1 1200792.AKYF01000010_gene2513 1.56e-05 53.1 COG0417@1|root,COG0417@2|Bacteria,1TQJQ@1239|Firmicutes,4HF6F@91061|Bacilli 91061|Bacilli L DNA polymerase elongation subunit (Family B) - - - - - - - - - - - - - k59_1393909_1 1123368.AUIS01000007_gene2676 7.45e-69 235.0 COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria,2NCRZ@225057|Acidithiobacillales 225057|Acidithiobacillales S Uncharacterized protein conserved in bacteria (DUF2309) - - - ko:K09822 - - - - ko00000 - - - DUF2309 k59_246945_1 948071.S4S2L2_9CAUD 1.4e-05 53.9 4QHQ5@10239|Viruses,4QR7K@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1544199_1 216595.PFLU_5885 7.58e-28 111.0 COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,1S612@1236|Gammaproteobacteria,1YN50@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family ygfA GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298 5-FTHF_cyc-lig k59_1085495_1 443144.GM21_2318 8.02e-34 122.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,42RJQ@68525|delta/epsilon subdivisions,2WNDS@28221|Deltaproteobacteria,43UMR@69541|Desulfuromonadales 28221|Deltaproteobacteria F Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_1085495_2 243231.GSU1242 5.27e-13 68.2 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WIS3@28221|Deltaproteobacteria,43TQ7@69541|Desulfuromonadales 28221|Deltaproteobacteria H PFAM aminotransferase, class I and II aspB - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1245326_2 1279017.AQYJ01000026_gene57 3.78e-10 61.6 COG1360@1|root,COG2885@1|root,COG1360@2|Bacteria,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,1T4AK@1236|Gammaproteobacteria,46ACU@72275|Alteromonadaceae 1236|Gammaproteobacteria M OmpA family - - - - - - - - - - - - DUF11,OmpA k59_1512455_1 1260251.SPISAL_01360 1.95e-61 213.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_189295_1 378806.STAUR_3393 3.07e-53 185.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIVD@28221|Deltaproteobacteria,2YYUH@29|Myxococcales 28221|Deltaproteobacteria NU Type II/IV secretion system protein pulE-3 - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_189295_2 1123279.ATUS01000001_gene1737 1.38e-05 50.1 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1J50R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_354059_1 1123354.AUDR01000012_gene1902 3.32e-16 82.8 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,1KSVV@119069|Hydrogenophilales 119069|Hydrogenophilales T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA k59_100648_2 1147094.H6X3R5_9CAUD 3.13e-79 249.0 4QAM2@10239|Viruses,4QV3W@35237|dsDNA viruses no RNA stage,4QPGK@28883|Caudovirales,4QIRV@10662|Myoviridae 10662|Myoviridae S 5'-3' exonuclease, N-terminal resolvase-like domain - - - - - - - - - - - - - k59_301964_1 765913.ThidrDRAFT_4129 1.03e-24 105.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,1X0JE@135613|Chromatiales 135613|Chromatiales L PFAM transposase mutator type - - - - - - - - - - - - Transposase_mut k59_404446_1 313612.L8106_14125 4.16e-37 144.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1GPUH@1117|Cyanobacteria,1HEB5@1150|Oscillatoriales 1117|Cyanobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - AAA_16,Guanylate_cyc k59_1245346_1 1379698.RBG1_1C00001G1403 3.44e-94 297.0 COG2133@1|root,COG2133@2|Bacteria,2NNSP@2323|unclassified Bacteria 2|Bacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - CBM_2,GSDH k59_18119_1 1229909.NSED_00425 8.37e-39 147.0 COG0642@1|root,arCOG02358@2157|Archaea 2157|Archaea T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k59_1603023_1 1121878.AUGL01000018_gene16 7.04e-15 77.8 COG1651@1|root,COG1651@2|Bacteria,1MVAC@1224|Proteobacteria,1S34E@1236|Gammaproteobacteria 1236|Gammaproteobacteria O COG1651 Protein-disulfide isomerase - - - - - - - - - - - - Thioredoxin_4 k59_1245347_1 926550.CLDAP_16150 6.39e-94 289.0 COG2128@1|root,COG2128@2|Bacteria 2|Bacteria S hydroperoxide reductase activity - - - - - - - - - - - - CMD,DUF3179 k59_404454_1 754477.Q7C_987 8.23e-77 244.0 COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,1RMB8@1236|Gammaproteobacteria,46007@72273|Thiotrichales 72273|Thiotrichales S DNA recombination protein RmuC - - - ko:K09760 - - - - ko00000 - - - RmuC k59_1137550_1 192875.XP_004343285.1 8.38e-33 130.0 COG1372@1|root,2QRRC@2759|Eukaryota,39SG8@33154|Opisthokonta 33154|Opisthokonta L reductase - - - - - - - - - - - - Ribonuc_red_lgC k59_835202_1 1158318.ATXC01000001_gene363 1.47e-43 161.0 COG4796@1|root,COG4796@2|Bacteria,2G44M@200783|Aquificae 200783|Aquificae U Type II and III secretion system protein - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - Secretin,Secretin_N k59_1030000_1 1120985.AUMI01000017_gene2729 2.56e-60 191.0 COG2930@1|root,COG2930@2|Bacteria,1VBSP@1239|Firmicutes,4H54G@909932|Negativicutes 909932|Negativicutes S Las17-binding protein actin regulator - - - - - - - - - - - - Ysc84 k59_1393955_1 247156.PNF1_1350 2.59e-23 105.0 COG2425@1|root,COG2425@2|Bacteria,2GMHF@201174|Actinobacteria 201174|Actinobacteria S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - VWA_2 k59_1452543_1 1123020.AUIE01000027_gene4589 1.04e-12 77.8 COG0402@1|root,COG0402@2|Bacteria,1MUPT@1224|Proteobacteria,1SYCI@1236|Gammaproteobacteria,1YEMD@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria F Amidohydrolase family guaD - 3.5.4.3 ko:K01487 ko00230,ko01100,map00230,map01100 - R01676 RC00204 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_1665904_1 566466.NOR53_1134 1.92e-69 216.0 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1J4XN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_100679_1 502025.Hoch_3843 3.7e-39 141.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WJY0@28221|Deltaproteobacteria,2YUIU@29|Myxococcales 28221|Deltaproteobacteria F Belongs to the SAICAR synthetase family purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_1137557_1 1121403.AUCV01000009_gene1466 2.25e-78 236.0 2DKVG@1|root,30GRY@2|Bacteria,1RDQT@1224|Proteobacteria,42V8G@68525|delta/epsilon subdivisions,2WRP8@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Cytochrome P460 - - - - - - - - - - - - Cytochrome_P460 k59_519156_1 1280952.HJA_03591 1.85e-58 203.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,43WSR@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_1544266_1 754476.Q7A_882 2.05e-19 90.9 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1RMSA@1236|Gammaproteobacteria 1236|Gammaproteobacteria U MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_1544266_2 1122604.JONR01000015_gene141 1.06e-35 130.0 COG1196@1|root,COG1196@2|Bacteria,1NGHR@1224|Proteobacteria,1RQW7@1236|Gammaproteobacteria,1X6TU@135614|Xanthomonadales 135614|Xanthomonadales D Protein of unknown function (DUF3450) - - - - - - - - - - - - DUF3450 k59_519170_1 857087.Metme_3216 9.98e-74 235.0 COG0591@1|root,COG0591@2|Bacteria,1N8H2@1224|Proteobacteria,1RR54@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_1393971_1 575540.Isop_2172 5.86e-79 261.0 COG3383@1|root,COG3383@2|Bacteria,2J4XN@203682|Planctomycetes 203682|Planctomycetes C 2Fe-2S iron-sulfur cluster binding domain - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_835249_1 865937.Gilli_0859 7.29e-19 95.1 COG1680@1|root,COG1680@2|Bacteria,4NIG6@976|Bacteroidetes,1I4JZ@117743|Flavobacteriia 976|Bacteroidetes V COGs COG1680 Beta-lactamase class C and other penicillin binding protein - - - - - - - - - - - - Beta-lactamase k59_1338604_1 396588.Tgr7_0643 6.58e-37 129.0 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,1WY9X@135613|Chromatiales 135613|Chromatiales S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_719082_1 1163617.SCD_n00836 1.28e-32 128.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2VHJ4@28216|Betaproteobacteria 28216|Betaproteobacteria S peptidase U62, modulator of DNA gyrase pmbA - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_873607_1 298654.FraEuI1c_4490 8.59e-21 93.2 COG4221@1|root,COG4221@2|Bacteria,2GP05@201174|Actinobacteria 201174|Actinobacteria L Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_873607_2 314345.SPV1_01767 1.2e-05 46.6 COG5424@1|root,COG5424@2|Bacteria,1QVK0@1224|Proteobacteria 1224|Proteobacteria H Iron-containing redox enzyme - - - - - - - - - - - - Haem_oxygenas_2 k59_768528_1 1504981.KO116_3985 2.61e-08 54.7 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1XH2Q@135619|Oceanospirillales 135619|Oceanospirillales G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_768528_2 435908.IDSA_02105 4.05e-81 249.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,2QF19@267893|Idiomarinaceae 1236|Gammaproteobacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_3924,iPC815.YPO3501 Pterin_bind k59_835269_1 472759.Nhal_2450 6.93e-84 273.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales 135613|Chromatiales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_354126_1 1193181.BN10_460045 7.4e-42 156.0 COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,2GIZP@201174|Actinobacteria,4FESC@85021|Intrasporangiaceae 201174|Actinobacteria I Acetyl-CoA carboxylase, central region - - - - - - - - - - - - ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans k59_678152_1 886293.Sinac_6796 1.38e-60 211.0 COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,2IX8E@203682|Planctomycetes 203682|Planctomycetes O PA domain - - - - - - - - - - - - PA,PD40,PDZ_2,Peptidase_M28 k59_1544311_1 1201290.M902_2117 1.6e-46 155.0 COG0720@1|root,COG0720@2|Bacteria,1RKYI@1224|Proteobacteria,4382Q@68525|delta/epsilon subdivisions,2WX5Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_1338629_2 76114.ebA3150 4.78e-49 169.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2W1Q4@28216|Betaproteobacteria,2KXXH@206389|Rhodocyclales 206389|Rhodocyclales C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_873626_1 177437.HRM2_41440 6.88e-19 85.9 COG0399@1|root,COG0399@2|Bacteria,1PRVB@1224|Proteobacteria,431RA@68525|delta/epsilon subdivisions,2X518@28221|Deltaproteobacteria,2MP3U@213118|Desulfobacterales 28221|Deltaproteobacteria M UDP-4-amino-4-deoxy-L-arabinose aminotransferase - - - - - - - - - - - - Y2_Tnp k59_404536_1 1158762.KB898040_gene1347 7.37e-25 104.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,1WXY5@135613|Chromatiales 135613|Chromatiales L COG3039 Transposase and inactivated derivatives, IS5 family - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_1305151_1 472759.Nhal_0029 1.92e-89 278.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria,1WWJG@135613|Chromatiales 135613|Chromatiales S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_247077_1 880072.Desac_2391 3.38e-31 124.0 COG0480@1|root,COG0480@2|Bacteria,1R0V4@1224|Proteobacteria,42M1F@68525|delta/epsilon subdivisions,2WIYM@28221|Deltaproteobacteria,2MR6X@213462|Syntrophobacterales 28221|Deltaproteobacteria J Elongation factor Tu domain 2 fusA-1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_247077_2 555079.Toce_2084 0.000464 42.7 COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia,42FD2@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k59_1452617_1 1114856.C496_22234 1.57e-17 79.7 COG2020@1|root,arCOG03580@2157|Archaea,2XY7P@28890|Euryarchaeota,23WBN@183963|Halobacteria 183963|Halobacteria O protein-S-isoprenylcysteine methyltransferase - - - - - - - - - - - - PEMT k59_1305182_1 1121937.AUHJ01000002_gene3447 2.55e-80 252.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,46455@72275|Alteromonadaceae 1236|Gammaproteobacteria P Ammonium Transporter Family amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_354172_1 449447.MAE_31770 3.08e-105 316.0 2BWJ3@1|root,2Z7IQ@2|Bacteria,1G3WZ@1117|Cyanobacteria 1117|Cyanobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_1603796_1 268746.Q58MY3_BPPRM 1.03e-26 115.0 4QDP2@10239|Viruses,4QT1E@28883|Caudovirales,4QI5J@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1246392_1 1298867.AUES01000051_gene4507 1.28e-95 301.0 COG0845@1|root,COG0845@2|Bacteria,1N97Q@1224|Proteobacteria,2U22Z@28211|Alphaproteobacteria,3K3DU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - Biotin_lipoyl_2,GAF,HlyD_3,HlyD_D23 k59_769502_1 673862.BABL1_415 1.61e-60 206.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42N1H@68525|delta/epsilon subdivisions,2WJ0R@28221|Deltaproteobacteria 28221|Deltaproteobacteria C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_520655_1 1056495.Calag_0836 1.89e-32 129.0 COG0028@1|root,arCOG01998@2157|Archaea,2XPT4@28889|Crenarchaeota 2157|Archaea E TPP binding domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1138575_1 1131266.ARWQ01000009_gene929 7.03e-81 246.0 COG0705@1|root,arCOG01768@2157|Archaea,41SKD@651137|Thaumarchaeota 651137|Thaumarchaeota E Rhomboid family - - - - - - - - - - - - Rhomboid k59_1138583_1 436308.Nmar_0314 1.14e-120 348.0 COG1608@1|root,arCOG00860@2157|Archaea,41SI4@651137|Thaumarchaeota 651137|Thaumarchaeota I Amino acid kinase family - - 2.7.4.26 ko:K06981 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R10093 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_1545456_1 1238182.C882_2003 3.28e-174 499.0 COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2TRZ0@28211|Alphaproteobacteria,2JPX8@204441|Rhodospirillales 204441|Rhodospirillales E homoserine dehydrogenase - - - - - - - - - - - - GFO_IDH_MocA,NAD_binding_3,SAF k59_405696_1 1121403.AUCV01000001_gene915 8.77e-53 176.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,42RFR@68525|delta/epsilon subdivisions,2WJYK@28221|Deltaproteobacteria,2MIFF@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF1732) yicC - - - - - - - - - - - DUF1732,YicC_N k59_303128_3 1122165.AUHS01000018_gene1946 5.03e-32 120.0 COG0462@1|root,COG0462@2|Bacteria,1MUV7@1224|Proteobacteria,1RY55@1236|Gammaproteobacteria,1JC7E@118969|Legionellales 118969|Legionellales F N-terminal domain of ribose phosphate pyrophosphokinase - - - - - - - - - - - - Pribosyltran,Pribosyltran_N k59_881841_1 991905.SL003B_2900 3.72e-40 150.0 COG0642@1|root,COG2770@1|root,COG0642@2|Bacteria,COG2770@2|Bacteria,1QTVA@1224|Proteobacteria,2U5EI@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase MA20_15235 - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_938470_1 330214.NIDE1848 6.13e-89 266.0 COG3055@1|root,COG3055@2|Bacteria 2|Bacteria G Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - - - - - - - - - - DUF3386,Kelch_1,Kelch_4,Kelch_5,fn3 k59_155118_1 36809.MAB_2389 6.97e-41 151.0 COG1053@1|root,COG1053@2|Bacteria,2GKS3@201174|Actinobacteria,233SE@1762|Mycobacteriaceae 201174|Actinobacteria C Succinate dehydrogenase fumarate reductase flavoprotein subunit ifcA - 1.3.99.5 ko:K16051 ko00984,ko01120,map00984,map01120 - R01834 RC00145 ko00000,ko00001,ko01000 - - - FAD_binding_2 k59_363084_1 330214.NIDE0516 5.54e-36 135.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding hcf136 - - - - - - - - - - - BNR,Sortilin-Vps10 k59_1461622_1 1144319.PMI16_03305 1.43e-64 209.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,4730B@75682|Oxalobacteraceae 28216|Betaproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_881855_1 1316444.K645_506 6.29e-08 55.5 COG0770@1|root,COG0770@2|Bacteria,4NDWD@976|Bacteroidetes,1HY7Q@117743|Flavobacteriia,3IV5E@39782|Blattabacteriaceae 976|Bacteroidetes M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_881855_2 515635.Dtur_1252 1.36e-30 120.0 COG0769@1|root,COG0769@2|Bacteria 2|Bacteria M UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity murE - 6.3.2.10,6.3.2.13 ko:K01928,ko:K15792 ko00300,ko00550,map00300,map00550 - R02788,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1191481_1 395493.BegalDRAFT_2181 1.64e-46 161.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,4625S@72273|Thiotrichales 72273|Thiotrichales K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_985302_2 2340.JV46_20560 4.17e-11 63.5 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,1J51N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008653,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1903509 - ko:K19804 - - - - ko00000 - - - TPR_16,TPR_19,TPR_7,TPR_8 k59_311371_2 110663.KI911558_gene2238 2.69e-66 209.0 COG0066@1|root,COG0066@2|Bacteria,1G2Y2@1117|Cyanobacteria,1GZEN@1129|Synechococcus 1117|Cyanobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_311372_1 644548.SCNU_07303 1.47e-22 102.0 COG1020@1|root,COG1020@2|Bacteria,2GKU0@201174|Actinobacteria,4GCIR@85026|Gordoniaceae 201174|Actinobacteria Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_776457_1 436308.Nmar_0574 2.73e-29 104.0 arCOG08736@1|root,arCOG08736@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_621661_1 330214.NIDE1127 2.57e-115 337.0 COG0492@1|root,COG0492@2|Bacteria,3J0M0@40117|Nitrospirae 40117|Nitrospirae C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_3 k59_1403037_2 861299.J421_4402 2.03e-12 68.9 COG1459@1|root,COG1459@2|Bacteria,1ZT63@142182|Gemmatimonadetes 2|Bacteria U Type II secretion system (T2SS), protein F xpsF GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF k59_881880_1 1173024.KI912148_gene4502 7.18e-17 80.1 COG1063@1|root,COG1063@2|Bacteria,1FZZE@1117|Cyanobacteria 1117|Cyanobacteria E PFAM Alcohol dehydrogenase - - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N,Shikimate_DH k59_881880_2 1137799.GZ78_16070 1.35e-38 145.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,1XMWY@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_155174_1 1249480.B649_11370 3.07e-18 89.4 COG2199@1|root,COG5000@1|root,COG2199@2|Bacteria,COG5000@2|Bacteria,1RGCV@1224|Proteobacteria,42YPK@68525|delta/epsilon subdivisions,2YTDC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T signal transduction response regulator (GGDEF - - - - - - - - - - - - GGDEF k59_255337_1 330214.NIDE0411 1.02e-82 263.0 COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria 2|Bacteria P sulfate adenylyltransferase (ATP) activity cysC - 2.7.1.25,2.7.7.4 ko:K00860,ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,GTP_EFTU,GTP_EFTU_D3 k59_199652_1 1026882.MAMP_01416 1.06e-59 209.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,4608A@72273|Thiotrichales 72273|Thiotrichales T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K10715 ko02020,ko02024,map02020,map02024 M00517 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - CHASE8,HATPase_c,HisKA,Hpt,Response_reg k59_881894_1 1411123.JQNH01000001_gene3810 1.33e-23 99.8 COG1167@1|root,COG1167@2|Bacteria,1MVGT@1224|Proteobacteria,2TRK7@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - ko:K00375 - - - - ko00000,ko03000 - - - Aminotran_1_2,GntR k59_881894_2 1122201.AUAZ01000046_gene2164 2.08e-26 107.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0C@1236|Gammaproteobacteria,465BZ@72275|Alteromonadaceae 1236|Gammaproteobacteria H Aminotransferase class-III - - 2.6.1.18 ko:K00822 ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100 - R00907,R04187 RC00008,RC00062,RC00160 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_468866_1 262316.MAP_2670c 4.47e-35 129.0 COG1023@1|root,COG1023@2|Bacteria,2I2DH@201174|Actinobacteria,232XI@1762|Mycobacteriaceae 201174|Actinobacteria G 6-phosphogluconate dehydrogenase gnd2 - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv1122 6PGD,NAD_binding_2 k59_468866_2 153496.JNAB01000018_gene1669 7.64e-46 163.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,2JR0F@204441|Rhodospirillales 204441|Rhodospirillales G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2,5.3.1.9 ko:K01810,ko:K13810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00004,M00007,M00114 R01827,R02739,R02740,R03321 RC00376,RC00439,RC00563,RC00604 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI,TAL_FSA k59_311419_1 502025.Hoch_6187 3.56e-65 219.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,42Q8W@68525|delta/epsilon subdivisions,2WJVN@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - - - - - - - - - - PD40,Peptidase_S9 k59_1347749_1 1122139.KB907870_gene1066 5.6e-74 242.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1XH4H@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_938546_1 1210046.B277_13124 8.23e-96 292.0 COG0604@1|root,COG0604@2|Bacteria,2GN47@201174|Actinobacteria,4FEIZ@85021|Intrasporangiaceae 201174|Actinobacteria C NAD(P)H quinone oxidoreductase qor - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_1347753_1 985665.HPL003_13025 3.5e-48 171.0 COG0074@1|root,COG0074@2|Bacteria,1UHQ6@1239|Firmicutes,4H9VN@91061|Bacilli,26W1C@186822|Paenibacillaceae 91061|Bacilli C CoA-ligase - - - ko:K02381 - - - - ko00000 - - - CoA_binding,Ligase_CoA k59_727402_1 754476.Q7A_1017 7.11e-21 92.4 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,45ZR5@72273|Thiotrichales 72273|Thiotrichales M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_727402_2 228410.NE0993 4.99e-28 112.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2VI7I@28216|Betaproteobacteria,3725K@32003|Nitrosomonadales 28216|Betaproteobacteria M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_1148453_1 290397.Adeh_2001 2.18e-77 240.0 COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,42NQM@68525|delta/epsilon subdivisions,2WK76@28221|Deltaproteobacteria 28221|Deltaproteobacteria C denitrification pathway - - - - - - - - - - - - Ni_hydr_CYTB k59_1148453_2 404589.Anae109_1805 5.02e-34 127.0 COG3005@1|root,COG3005@2|Bacteria,1QYG3@1224|Proteobacteria,43CC8@68525|delta/epsilon subdivisions,2X7N4@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Cytochrome c3 - - - - - - - - - - - - Paired_CXXCH_1 k59_1461738_1 349124.Hhal_1654 1.35e-17 79.0 COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1WYJU@135613|Chromatiales 135613|Chromatiales S Modulates RecA activity recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX k59_1461738_2 1304275.C41B8_18030 4.36e-81 251.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,1RMHP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_155218_1 278963.ATWD01000001_gene3210 3.82e-40 149.0 COG1506@1|root,COG1506@2|Bacteria,3Y357@57723|Acidobacteria 57723|Acidobacteria E PFAM Tannase and feruloyl esterase - - - - - - - - - - - - Tannase k59_199684_1 247634.GPB2148_2665 2.4e-43 156.0 COG5361@1|root,COG5361@2|Bacteria,1R4D9@1224|Proteobacteria 1224|Proteobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - DUF1214 k59_881916_1 283699.D172_3476 3.78e-37 135.0 COG5429@1|root,COG5429@2|Bacteria,1MW6R@1224|Proteobacteria,1S834@1236|Gammaproteobacteria,2Q3W8@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF1223) - - - - - - - - - - - - DUF1223 k59_776509_1 519989.ECTPHS_08468 1.8e-21 88.6 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,1WY5S@135613|Chromatiales 135613|Chromatiales J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_776509_2 323261.Noc_0810 2.09e-63 201.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1WX9S@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_199688_1 1479237.JMLY01000001_gene1286 5.88e-75 236.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,46563@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006780,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046394,GO:0046483,GO:0046501,GO:0046502,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO3734,iSBO_1134.SBO_4018 URO-D k59_155228_1 2340.JV46_03100 6.12e-22 89.0 COG1030@1|root,COG1030@2|Bacteria 2|Bacteria - - nfeD - - ko:K07403 - - - - ko00000 - - - NfeD k59_155228_2 1122201.AUAZ01000001_gene2231 1.78e-43 149.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,464MH@72275|Alteromonadaceae 1236|Gammaproteobacteria O COG0330 Membrane protease subunits, stomatin prohibitin homologs qmcA - - - - - - - - - - - Band_7 k59_938587_1 59374.Fisuc_0585 1.21e-32 127.0 COG0688@1|root,COG0688@2|Bacteria 2|Bacteria I phosphatidylethanolamine metabolic process psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_1148484_1 203907.Bfl448 9.13e-24 91.7 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,282TT@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria K 'Cold-shock' DNA-binding domain cspC GO:0001072,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031554,GO:0031564,GO:0043242,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051087,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0060567,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_1096561_1 1198232.CYCME_2384 1.41e-35 131.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,4607E@72273|Thiotrichales 72273|Thiotrichales E PFAM aminotransferase class-III argD - 2.6.1.11,2.6.1.13,2.6.1.17 ko:K00819,ko:K00821 ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R00667,R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1096561_2 1123514.KB905899_gene1880 1.69e-70 220.0 COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,1S8F8@1236|Gammaproteobacteria,4638B@72273|Thiotrichales 72273|Thiotrichales S Urate oxidase N-terminal - - - - - - - - - - - - Urate_ox_N k59_728633_1 977880.RALTA_A0309 8.76e-59 202.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2VHVB@28216|Betaproteobacteria,1K472@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_201357_1 1298593.TOL_0124 2.29e-78 248.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1XHSI@135619|Oceanospirillales 135619|Oceanospirillales P Trk system potassium uptake protein trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1404970_1 316067.Geob_2692 2.8e-76 253.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,43UH5@69541|Desulfuromonadales 28221|Deltaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_313083_1 1298863.AUEP01000013_gene4093 4.34e-19 87.8 COG0438@1|root,COG0438@2|Bacteria,2ICGI@201174|Actinobacteria,4DT97@85009|Propionibacteriales 201174|Actinobacteria M Glycosyl transferases group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1,YHS k59_313083_2 1201293.AKXQ01000025_gene1256 1.74e-08 55.5 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_256595_1 1429916.X566_16120 2.13e-36 137.0 COG1960@1|root,COG1960@2|Bacteria,1N05C@1224|Proteobacteria,2TT9T@28211|Alphaproteobacteria,3JTG7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I acyl-CoA dehydrogenase MA20_06725 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_1349657_2 1408473.JHXO01000008_gene2655 4.2e-20 89.0 COG0330@1|root,COG0330@2|Bacteria,4NH8V@976|Bacteroidetes,2FQPC@200643|Bacteroidia 976|Bacteroidetes O SPFH Band 7 PHB domain protein - - - - - - - - - - - - Band_7 k59_201366_1 1121447.JONL01000004_gene2887 7.52e-24 106.0 COG4191@1|root,COG4191@2|Bacteria,1R682@1224|Proteobacteria,42P91@68525|delta/epsilon subdivisions,2WKQI@28221|Deltaproteobacteria,2M80U@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_9 k59_1193480_1 479433.Caci_0867 6.34e-37 137.0 COG0526@1|root,COG0526@2|Bacteria,2HZTZ@201174|Actinobacteria 201174|Actinobacteria CO COG0526, thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - AhpC-TSA k59_1193480_2 67267.JNXT01000011_gene975 2.57e-08 57.0 COG0526@1|root,COG0526@2|Bacteria,2HZTZ@201174|Actinobacteria 201174|Actinobacteria CO COG0526, thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - AhpC-TSA k59_416310_1 404589.Anae109_2480 3.91e-70 229.0 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,42MBU@68525|delta/epsilon subdivisions,2WIJP@28221|Deltaproteobacteria,2YWW6@29|Myxococcales 28221|Deltaproteobacteria O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_22787_1 1088721.NSU_0076 2.74e-35 139.0 COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2TSAJ@28211|Alphaproteobacteria,2K0DW@204457|Sphingomonadales 204457|Sphingomonadales G Glycosyl hydrolase 36 superfamily, catalytic domain - - - ko:K13688 - - - - ko00000,ko01000,ko01003 - GH94,GT84 - Glyco_hydro_36,Glyco_transf_36,Glycoamylase k59_777739_1 278963.ATWD01000001_gene4040 1e-12 70.5 COG0356@1|root,COG0356@2|Bacteria,3Y4CM@57723|Acidobacteria,2JJ5W@204432|Acidobacteriia 204432|Acidobacteriia C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_416330_1 1116472.MGMO_125c00130 3.75e-54 175.0 COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,1S6WD@1236|Gammaproteobacteria,1XEYA@135618|Methylococcales 135618|Methylococcales O Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein dsbB - - ko:K03611 - - - - ko00000,ko03110 5.A.2.1 - - DsbB k59_416330_2 1123499.KB908018_gene2192 6.16e-51 164.0 COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2VR7R@28216|Betaproteobacteria,2KQXS@206351|Neisseriales 206351|Neisseriales E Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione gloA - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_623488_1 330214.NIDE0992 4.56e-27 104.0 COG1039@1|root,COG1039@2|Bacteria 2|Bacteria L RNA-DNA hybrid ribonuclease activity rnhC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03471 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DUF3378,RNase_HII k59_623488_2 330214.NIDE0993 9.05e-24 98.6 COG0501@1|root,COG0501@2|Bacteria 2|Bacteria O metalloendopeptidase activity - - - - - - - - - - - - Peptidase_M48 k59_940178_1 192952.MM_0047 7.75e-59 201.0 COG0160@1|root,arCOG00915@2157|Archaea,2Y83J@28890|Euryarchaeota,2NBNP@224756|Methanomicrobia 224756|Methanomicrobia E Aminotransferase class-III - - 2.6.1.19,2.6.1.76 ko:K00823,ko:K00836 ko00250,ko00260,ko00410,ko00640,ko00650,ko01100,ko01120,ko01210,ko01230,map00250,map00260,map00410,map00640,map00650,map01100,map01120,map01210,map01230 M00027,M00033 R00908,R01648,R06977 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_201436_1 511.JT27_00705 3.68e-09 63.5 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2VIK2@28216|Betaproteobacteria,3T4HZ@506|Alcaligenaceae 28216|Betaproteobacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_1096644_1 671143.DAMO_2315 4.59e-84 257.0 COG0289@1|root,COG0289@2|Bacteria,2NPX5@2323|unclassified Bacteria 2|Bacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215,ko:K03546 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000,ko03400 - - iIT341.HP0510,iLJ478.TM1520,iSbBS512_1146.SbBS512_E0035 DapB_C,DapB_N k59_416349_1 1167006.UWK_01091 4.72e-37 136.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2WIWW@28221|Deltaproteobacteria,2MIPA@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM NAD-dependent glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_416349_2 456442.Mboo_0972 7.53e-11 60.8 COG1918@1|root,arCOG02102@2157|Archaea,2Y1P2@28890|Euryarchaeota,2NA56@224756|Methanomicrobia 224756|Methanomicrobia P FeoA - - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA k59_416349_3 1203568.HMPREF1484_00521 7.95e-32 126.0 COG0370@1|root,COG0370@2|Bacteria,2GTV2@201174|Actinobacteria 201174|Actinobacteria P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoA,FeoB_C,FeoB_N,Gate k59_364841_1 1469245.JFBG01000027_gene1488 1.27e-15 77.8 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,1RP8V@1236|Gammaproteobacteria,1WWVE@135613|Chromatiales 135613|Chromatiales M PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C - - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_364841_2 1286106.MPL1_12498 1.05e-13 68.2 2ENKU@1|root,33G87@2|Bacteria,1NMH6@1224|Proteobacteria,1SGDI@1236|Gammaproteobacteria,461EH@72273|Thiotrichales 72273|Thiotrichales - - - - - - - - - - - - - - - k59_883173_1 443144.GM21_0752 4.09e-58 196.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,42M3N@68525|delta/epsilon subdivisions,2WISS@28221|Deltaproteobacteria 28221|Deltaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_883173_2 582515.KR51_00032780 0.000199 44.7 COG0483@1|root,COG0483@2|Bacteria,1G0GD@1117|Cyanobacteria 1117|Cyanobacteria G Inositol monophosphatase suhB GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_805893_1 35754.JNYJ01000020_gene226 3.85e-51 179.0 COG1409@1|root,COG1409@2|Bacteria,2GIT1@201174|Actinobacteria,4DM0J@85008|Micromonosporales 201174|Actinobacteria S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_852908_1 882086.SacxiDRAFT_0186 1.8e-17 86.7 COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4DZTM@85010|Pseudonocardiales 201174|Actinobacteria I Acetyl propionyl-CoA carboxylase, alpha subunit accA2 - 6.4.1.1,6.4.1.3,6.4.1.4 ko:K01959,ko:K01965,ko:K01968 ko00020,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01120,ko01130,ko01200,ko01230,map00020,map00280,map00620,map00630,map00640,map00720,map01100,map01120,map01130,map01200,map01230 M00036,M00173,M00373,M00620,M00741 R00344,R01859,R04138 RC00040,RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv0973c Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1526323_1 1057002.KB905370_gene1391 0.000191 48.1 COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,2UAQH@28211|Alphaproteobacteria,4BMR4@82115|Rhizobiaceae 28211|Alphaproteobacteria O Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - - - - - - - - - - PEMT k59_1275727_1 1217715.F994_01849 1.43e-12 70.5 COG1670@1|root,COG1670@2|Bacteria,1RCX2@1224|Proteobacteria,1S42B@1236|Gammaproteobacteria,3NM0U@468|Moraxellaceae 1236|Gammaproteobacteria J Acetyltransferase (GNAT) domain - - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 k59_490036_1 1250232.JQNJ01000001_gene2783 1.02e-05 49.3 COG4888@1|root,COG4888@2|Bacteria,4NEE8@976|Bacteroidetes,1HX4C@117743|Flavobacteriia 976|Bacteroidetes S PFAM ASPIC and UnbV - - - - - - - - - - - - FG-GAP,UnbV_ASPIC,VCBS k59_1375014_1 582744.Msip34_2812 3.22e-52 179.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,2KKU5@206350|Nitrosomonadales 206350|Nitrosomonadales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_1375014_2 1392838.AWNM01000009_gene2765 1.15e-15 76.6 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,3T1X3@506|Alcaligenaceae 28216|Betaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3 k59_490038_1 1191523.MROS_1977 9.77e-46 167.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria 2|Bacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin korA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_956681_1 436308.Nmar_1540 3.92e-71 223.0 COG0122@1|root,arCOG00464@2157|Archaea,41SHE@651137|Thaumarchaeota 651137|Thaumarchaeota L 8-oxoguanine DNA glycosylase - - 4.2.99.18 ko:K03660 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD k59_956681_2 436308.Nmar_1539 2.05e-45 157.0 COG1236@1|root,arCOG00541@2157|Archaea,41SAJ@651137|Thaumarchaeota 651137|Thaumarchaeota J exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07577 - - - - ko00000 - - - Beta-Casp,Lactamase_B_6,RMMBL k59_1583787_1 338963.Pcar_1001 1.05e-114 344.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,42M6I@68525|delta/epsilon subdivisions,2WJTV@28221|Deltaproteobacteria,43T4H@69541|Desulfuromonadales 28221|Deltaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - iAF987.Gmet_1886 PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1526333_1 439235.Dalk_1693 3.15e-18 89.7 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,42MRN@68525|delta/epsilon subdivisions,2WJCH@28221|Deltaproteobacteria,2MIB2@213118|Desulfobacterales 28221|Deltaproteobacteria M PFAM NAD dependent epimerase dehydratase family - - 5.1.3.2,5.1.3.7 ko:K01784,ko:K02473 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R00418,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_384636_1 1125863.JAFN01000001_gene890 2.99e-172 492.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,42M56@68525|delta/epsilon subdivisions,2WJ8W@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM isocitrate isopropylmalate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_435296_1 392499.Swit_3645 2.83e-62 203.0 COG2159@1|root,COG2159@2|Bacteria,1PZ2K@1224|Proteobacteria,2UZUA@28211|Alphaproteobacteria,2K9EF@204457|Sphingomonadales 204457|Sphingomonadales S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_490054_1 330214.NIDE3591 3.51e-85 276.0 COG0744@1|root,COG0744@2|Bacteria,3J1FP@40117|Nitrospirae 40117|Nitrospirae M Transglycosylase - - 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_225999_1 485916.Dtox_0050 9.31e-06 55.1 COG4251@1|root,COG5002@1|root,COG4251@2|Bacteria,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity kinE - 2.7.13.3 ko:K02482,ko:K02491,ko:K13533,ko:K14986 ko02020,map02020 M00485,M00524 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF,GAF_2,GGDEF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_1062309_2 761193.Runsl_5515 3.08e-14 72.0 COG0839@1|root,COG0839@2|Bacteria,4NP2V@976|Bacteroidetes,47PS7@768503|Cytophagia 976|Bacteroidetes C PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6 nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_171526_1 713587.THITH_13795 7.28e-17 77.4 COG1266@1|root,COG1266@2|Bacteria,1ND7U@1224|Proteobacteria,1T0I9@1236|Gammaproteobacteria 1236|Gammaproteobacteria S CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi k59_171526_2 870187.Thini_3078 2.09e-25 99.0 2E2DR@1|root,32XIE@2|Bacteria 2|Bacteria S SseB protein N-terminal domain - - - - - - - - - - - - SseB k59_591550_1 338963.Pcar_2171 2.42e-32 129.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,43T20@69541|Desulfuromonadales 28221|Deltaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_648877_2 426716.JOAJ01000002_gene2067 1.22e-23 100.0 COG0318@1|root,COG0318@2|Bacteria,2GMVB@201174|Actinobacteria,4FVFU@85025|Nocardiaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_852952_1 257313.BP3709 6.09e-10 64.7 COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2VKB0@28216|Betaproteobacteria 28216|Betaproteobacteria C PFAM L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_698012_1 1523503.JPMY01000002_gene3940 8.64e-48 173.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9 k59_278710_1 76869.PputGB1_1699 4.61e-22 93.2 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,1RNWH@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain cusR GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0042221,GO:0042802,GO:0046688,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_1222431_2 1122604.JONR01000014_gene218 1.48e-43 150.0 COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,1S8HN@1236|Gammaproteobacteria,1X62E@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_385845_1 1121459.AQXE01000001_gene2751 1.13e-64 207.0 28IR7@1|root,2Z8QR@2|Bacteria,1PBTP@1224|Proteobacteria,42Z7V@68525|delta/epsilon subdivisions,2WTZ3@28221|Deltaproteobacteria,2M8NA@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_807115_1 1122611.KB903958_gene4080 8.2e-23 99.4 COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria,4EGQA@85012|Streptosporangiales 201174|Actinobacteria V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_906283_1 316274.Haur_3293 3.18e-13 69.7 COG0784@1|root,COG2203@1|root,COG3852@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG3852@2|Bacteria,2GBQK@200795|Chloroflexi,3776Y@32061|Chloroflexia 32061|Chloroflexia T SMART PAS domain containing protein - - - - - - - - - - - - GAF_2,HATPase_c,PAS_4,Response_reg k59_906283_2 378806.STAUR_3340 1.13e-102 327.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,2YUJ6@29|Myxococcales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_592460_2 1229909.NSED_02835 5.46e-30 112.0 COG0580@1|root,arCOG04431@2157|Archaea,41S5R@651137|Thaumarchaeota 651137|Thaumarchaeota G Major Intrinsic Protein - - - ko:K06188,ko:K09866 ko04962,ko04976,map04962,map04976 - - - ko00000,ko00001,ko02000 1.A.8 - - MIP k59_279582_1 316067.Geob_2938 2.64e-83 263.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MAV@68525|delta/epsilon subdivisions,2WJC9@28221|Deltaproteobacteria,43TBU@69541|Desulfuromonadales 28221|Deltaproteobacteria E Belongs to the alpha-IPM synthase homocitrate synthase family cimA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1484729_1 444860.E3SIW2_9CAUD 3.62e-85 261.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QI9F@10662|Myoviridae 10662|Myoviridae S Type III restriction enzyme, res subunit - - - - - - - - - - - - - k59_1484729_2 42345.XP_008797634.1 0.000357 45.1 2BY5I@1|root,2QWJR@2759|Eukaryota,37TWN@33090|Viridiplantae,3GHIF@35493|Streptophyta,3KZMA@4447|Liliopsida 35493|Streptophyta S CAAD domains of cyanobacterial aminoacyl-tRNA synthetase - GO:0000229,GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0006091,GO:0008150,GO:0008152,GO:0009295,GO:0009507,GO:0009508,GO:0009521,GO:0009522,GO:0009526,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0009719,GO:0009725,GO:0009737,GO:0009767,GO:0009773,GO:0009941,GO:0009987,GO:0010033,GO:0015979,GO:0016020,GO:0019684,GO:0019904,GO:0022900,GO:0030093,GO:0031967,GO:0031975,GO:0031976,GO:0031984,GO:0032991,GO:0033993,GO:0034357,GO:0042221,GO:0042646,GO:0042651,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0055035,GO:0055114,GO:0097159,GO:0097305,GO:0098796,GO:0098807,GO:1901363,GO:1901700 - - - - - - - - - - CAAD k59_172174_1 580332.Slit_2746 5.26e-43 158.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,44VDQ@713636|Nitrosomonadales 28216|Betaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_172174_2 765913.ThidrDRAFT_0919 0.000124 43.5 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1WWGK@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase, dimerisation - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_906288_1 458817.Shal_2606 3.13e-93 289.0 COG3137@1|root,COG3137@2|Bacteria,1RCKQ@1224|Proteobacteria,1S0GK@1236|Gammaproteobacteria,2QA2B@267890|Shewanellaceae 1236|Gammaproteobacteria M Protein of unknown function, DUF481 - - - - - - - - - - - - DUF481 k59_957530_1 930166.CD58_17465 1.16e-12 73.6 COG2911@1|root,COG2931@1|root,COG4932@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - ko:K11005 - - - - ko00000,ko02000,ko02042 1.C.11 - - Big_3_2,Cadherin_3,Calx-beta,DUF5011,He_PIG,HemolysinCabind,OmpA_membrane,PPC,RTX,RTX_C,TSP_3,VWA_2,fn3 k59_650039_1 1499967.BAYZ01000080_gene919 1.57e-19 87.4 COG3533@1|root,COG3533@2|Bacteria,2NNW0@2323|unclassified Bacteria 2|Bacteria S Beta-L-arabinofuranosidase, GH127 - - - - - - - - - - - - Glyco_hydro_127 k59_1010163_1 445686.E3SLN5_9CAUD 1.7e-84 254.0 4QHVS@10662|Myoviridae 10662|Myoviridae S PhoH-like protein - - - - - - - - - - - - - k59_75391_2 1401328.P856_264 2.33e-52 166.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2U9AQ@28211|Alphaproteobacteria,2JSPE@204441|Rhodospirillales 204441|Rhodospirillales O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_749029_1 1229909.NSED_08980 1.55e-67 213.0 COG0540@1|root,arCOG00911@2157|Archaea,41S6H@651137|Thaumarchaeota 651137|Thaumarchaeota F aspartate carbamoyltransferase pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_749029_2 436308.Nmar_1684 1.9e-11 64.7 arCOG08795@1|root,arCOG08795@2157|Archaea 2157|Archaea C copper ion binding - - - - - - - - - - - - - k59_1010164_1 686340.Metal_1832 5.06e-86 283.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1XDT8@135618|Methylococcales 135618|Methylococcales L DEAD DEAH box - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_650043_1 29760.VIT_01s0026g00820.t01 1.14e-26 111.0 COG1473@1|root,2QQEM@2759|Eukaryota,37JVC@33090|Viridiplantae,3GE17@35493|Streptophyta 35493|Streptophyta G IAA-amino acid hydrolase ILR1-like - - - ko:K14664 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_698946_1 1049564.TevJSym_bb00050 1.77e-74 241.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_650049_1 158500.BV97_00525 5.5e-25 104.0 COG2141@1|root,COG2141@2|Bacteria,1RGE2@1224|Proteobacteria,2U8AC@28211|Alphaproteobacteria,2K4MK@204457|Sphingomonadales 204457|Sphingomonadales C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_123595_1 315730.BcerKBAB4_5552 1.73e-25 102.0 COG4314@1|root,COG4314@2|Bacteria,1V86E@1239|Firmicutes,4HJXZ@91061|Bacilli,1ZH53@1386|Bacillus 91061|Bacilli C NosL nosL - - ko:K19342 - - - - ko00000 - - - NosL k59_1010172_1 330214.NIDE3313 5.3e-87 285.0 COG2132@1|root,COG2132@2|Bacteria 2|Bacteria Q Multicopper oxidase - - 1.16.3.3,1.7.2.1 ko:K00368,ko:K07233,ko:K22349 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Copper-bind,Cu-oxidase_2,Cu-oxidase_3 k59_8172_1 338963.Pcar_2388 5.84e-40 149.0 COG0644@1|root,COG0644@2|Bacteria,1PFC1@1224|Proteobacteria,42VN7@68525|delta/epsilon subdivisions,2WR8D@28221|Deltaproteobacteria 28221|Deltaproteobacteria C FAD binding domain - - 1.3.99.38 ko:K21401 - - - - ko00000,ko01000 - - - FAD_binding_3 k59_491174_1 314285.KT71_08279 6.34e-50 163.0 COG1764@1|root,COG1764@2|Bacteria,1RJIP@1224|Proteobacteria,1S6QM@1236|Gammaproteobacteria,1J9ZC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O redox protein, regulator of disulfide bond formation - - - - - - - - - - - - OsmC k59_491174_2 391613.RTM1035_17482 9.81e-71 238.0 COG0457@1|root,COG0457@2|Bacteria,1N01S@1224|Proteobacteria,2TSR4@28211|Alphaproteobacteria,46QG9@74030|Roseovarius 28211|Alphaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - - k59_491174_3 1040989.AWZU01000007_gene772 2.72e-06 50.4 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,3JVXH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Malic enzyme, NAD binding domain - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic k59_1222489_1 246200.SPO0677 1.96e-62 208.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,4NA9B@97050|Ruegeria 28211|Alphaproteobacteria IQ AMP-binding enzyme C-terminal domain MA20_29420 GO:0003674,GO:0003824,GO:0003996,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0071704 6.2.1.44,6.2.1.48 ko:K00666,ko:K02182,ko:K20034 ko00920,map00920 - R10820 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_332073_1 1382303.JPOM01000001_gene31 1.36e-77 242.0 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria,2KGBE@204458|Caulobacterales 204458|Caulobacterales S N-terminal domain of oxidoreductase - - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N k59_1375909_1 1121374.KB891576_gene656 1.69e-106 338.0 COG5276@1|root,COG5276@2|Bacteria,1R66X@1224|Proteobacteria,1S05Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria S LVIVD repeat - - - - - - - - - - - - LVIVD k59_1277032_1 316278.SynRCC307_1345 1.88e-79 255.0 COG0365@1|root,COG0365@2|Bacteria,1G0E7@1117|Cyanobacteria,1GZ2X@1129|Synechococcus 1117|Cyanobacteria H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_172199_2 396588.Tgr7_2259 4.49e-28 108.0 COG0457@1|root,COG0457@2|Bacteria,1R85G@1224|Proteobacteria,1S0MD@1236|Gammaproteobacteria,1WXM8@135613|Chromatiales 135613|Chromatiales S Tetratricopeptide repeat - - - - - - - - - - - - - k59_650066_2 444860.E3SJ64_9CAUD 1.39e-154 442.0 4QC2G@10239|Viruses,4QV3V@35237|dsDNA viruses no RNA stage,4QPRR@28883|Caudovirales,4QI1T@10662|Myoviridae 10662|Myoviridae S Ribonucleotide reductase, small chain - - - - - - - - - - - - - k59_385923_1 234267.Acid_4184 8.59e-96 311.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3Y37Y@57723|Acidobacteria 57723|Acidobacteria E Vitamin B12 dependent methionine synthase activation - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_592505_1 225117.XP_009350065.1 2.3e-20 90.5 COG0099@1|root,KOG3311@2759|Eukaryota 2759|Eukaryota J rRNA binding - GO:0000313,GO:0000314,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005763,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0071840,GO:0098798,GO:0140053,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_592505_2 998674.ATTE01000001_gene4300 1.04e-58 185.0 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,1S3P6@1236|Gammaproteobacteria,460T4@72273|Thiotrichales 72273|Thiotrichales J binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_491198_1 562970.Btus_0129 2.86e-07 57.4 COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,4HAKH@91061|Bacilli,2783Y@186823|Alicyclobacillaceae 91061|Bacilli J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0009986,GO:0030246,GO:0030247,GO:0044464,GO:2001065 6.1.1.24 ko:K09698 ko00970,ko01100,map00970,map01100 M00360 R03651,R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iSB619.SA_RS02860 tRNA-synt_1c k59_957574_1 224324.aq_1069 3.19e-15 75.5 COG1087@1|root,COG1087@2|Bacteria,2G3QB@200783|Aquificae 200783|Aquificae M Belongs to the NAD(P)-dependent epimerase dehydratase family galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_957574_2 1123368.AUIS01000005_gene447 3.64e-13 70.9 COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,1RP34@1236|Gammaproteobacteria,2NBSM@225057|Acidithiobacillales 225057|Acidithiobacillales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - 2.7.13.3 ko:K07711 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_84682_1 1454004.AW11_00461 5.04e-06 53.5 COG0500@1|root,COG0500@2|Bacteria,1N1Q5@1224|Proteobacteria,2W3DD@28216|Betaproteobacteria 28216|Betaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k59_1493999_2 1229909.NSED_00780 5.78e-34 118.0 COG0526@1|root,arCOG01218@2157|Archaea 2157|Archaea CO TIGRFAM Glutaredoxin-like domain protein - - - - - - - - - - - - Thioredoxin_3 k59_1493999_3 1229909.NSED_05375 2.35e-115 334.0 arCOG02703@1|root,arCOG02703@2157|Archaea 2157|Archaea S Methyltransferase type 11 - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 k59_1121990_1 1278073.MYSTI_03738 3.69e-09 58.2 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42MZZ@68525|delta/epsilon subdivisions,2WIQI@28221|Deltaproteobacteria,2YUSK@29|Myxococcales 28221|Deltaproteobacteria H MoeA C-terminal region (domain IV) - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1121990_2 693746.OBV_10090 5.95e-67 221.0 COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,2N6KX@216572|Oscillospiraceae 186801|Clostridia J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dus - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_1494001_1 485913.Krac_11458 4.49e-34 131.0 COG2801@1|root,COG2801@2|Bacteria,2G9MD@200795|Chloroflexi 200795|Chloroflexi L SPTR A9B8L4 Integrase catalytic region - - - - - - - - - - - - rve_3 k59_1230877_1 1042377.AFPJ01000020_gene2059 1.46e-39 149.0 COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,1RPD2@1236|Gammaproteobacteria,464NG@72275|Alteromonadaceae 1236|Gammaproteobacteria C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_16,TPR_19,TPR_20,TPR_8 k59_1230877_2 566466.NOR53_3405 9.66e-12 65.5 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,1RRHA@1236|Gammaproteobacteria,1J643@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_338830_1 290397.Adeh_2651 5.42e-84 265.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Y98@68525|delta/epsilon subdivisions,2WTXU@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_860958_1 1132509.C447_15531 9.5e-30 115.0 COG1250@1|root,arCOG00250@2157|Archaea,2XTMV@28890|Euryarchaeota,23RX3@183963|Halobacteria 183963|Halobacteria I 3-hydroxyacyl-CoA dehydrogenase hbd - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k59_860958_2 1004785.AMBLS11_07660 2.16e-24 100.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,464E8@72275|Alteromonadaceae 1236|Gammaproteobacteria I Belongs to the thiolase family atoB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_705685_1 382464.ABSI01000013_gene1635 2.28e-68 217.0 COG0667@1|root,COG0667@2|Bacteria,46UF5@74201|Verrucomicrobia 74201|Verrucomicrobia C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_659483_1 246197.MXAN_6060 1.41e-89 281.0 COG1232@1|root,COG1232@2|Bacteria,1R7EY@1224|Proteobacteria 1224|Proteobacteria H amine oxidase - - - - - - - - - - - - Amino_oxidase k59_1591797_1 1141662.OOA_01562 2.31e-47 172.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,3Z7UE@586|Providencia 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_233506_2 795359.TOPB45_0767 1.12e-42 144.0 COG0096@1|root,COG0096@2|Bacteria,2GHUB@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_1591802_1 203122.Sde_3098 7.13e-35 136.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,1RPDC@1236|Gammaproteobacteria,465B2@72275|Alteromonadaceae 1236|Gammaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_1230897_1 1517416.IDAT_09270 7.29e-91 278.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria,2QFD0@267893|Idiomarinaceae 1236|Gammaproteobacteria F Belongs to the phosphoglycerate kinase family pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - iSbBS512_1146.SbBS512_E3351 PGK k59_1230897_2 323261.Noc_2805 1.6e-161 469.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1WXEF@135613|Chromatiales 135613|Chromatiales G Belongs to the pyruvate kinase family - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_1230900_1 745411.B3C1_11334 1.27e-129 401.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5K5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_705700_1 1255043.TVNIR_1892 5.68e-104 309.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1WX6T@135613|Chromatiales 135613|Chromatiales I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_599411_1 387631.Asulf_00050 1.41e-40 143.0 COG1028@1|root,arCOG01259@2157|Archaea,2XSWX@28890|Euryarchaeota,2469N@183980|Archaeoglobi 183980|Archaeoglobi I Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059,ko:K07535 ko00061,ko00333,ko00362,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,ko01220,map00061,map00333,map00362,map00780,map01040,map01100,map01120,map01130,map01212,map01220 M00083,M00540,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R05582,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117,RC00154 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_131749_1 1278306.KB906906_gene451 7.3e-81 277.0 COG0507@1|root,COG1112@1|root,COG2852@1|root,COG0507@2|Bacteria,COG1112@2|Bacteria,COG2852@2|Bacteria,3790J@32066|Fusobacteria 32066|Fusobacteria L Protein of unknown function (DUF559) - - - - - - - - - - - - AAA_11,AAA_12,AAA_30,DUF559 k59_705701_1 765912.Thimo_2604 1.84e-157 454.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_860986_1 717773.Thicy_1126 5.38e-90 271.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,1RM7Y@1236|Gammaproteobacteria,45ZX8@72273|Thiotrichales 72273|Thiotrichales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_1647257_2 472759.Nhal_1703 8.23e-100 298.0 COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria 1224|Proteobacteria C radical SAM domain protein - - 1.97.1.4 ko:K04070 - - - - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_1647258_1 399795.CtesDRAFT_PD3115 1.64e-48 164.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,4ABGB@80864|Comamonadaceae 28216|Betaproteobacteria I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k59_1647261_1 436308.Nmar_1398 9.69e-100 309.0 COG3593@1|root,arCOG03235@2157|Archaea,41SZV@651137|Thaumarchaeota 651137|Thaumarchaeota L AAA ATPase domain - - - - - - - - - - - - AAA_15 k59_816518_1 1341155.FSS13T_14390 1.42e-09 62.4 COG0526@1|root,COG0526@2|Bacteria,4NH2A@976|Bacteroidetes,1HXIW@117743|Flavobacteriia,2NTW5@237|Flavobacterium 976|Bacteroidetes CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA,Redoxin,Thioredoxin_8 k59_816518_3 1278073.MYSTI_02808 1.33e-30 117.0 COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria 1224|Proteobacteria S major pilin protein fima MA20_16755 - - - - - - - - - - - DUF1028 k59_444500_1 760568.Desku_3484 2.8e-52 180.0 COG1797@1|root,COG1797@2|Bacteria,1TNY2@1239|Firmicutes,247PU@186801|Clostridia,2612H@186807|Peptococcaceae 186801|Clostridia H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 k59_1122049_1 713586.KB900536_gene2638 8.07e-52 184.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1WWF6@135613|Chromatiales 135613|Chromatiales M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_755968_1 402626.Rpic_0674 9.03e-62 214.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,1K6EM@119060|Burkholderiaceae 28216|Betaproteobacteria NU Pilus assembly protein - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_1591830_1 981369.JQMJ01000003_gene7447 2.65e-61 209.0 COG0305@1|root,COG0305@2|Bacteria,2GKXQ@201174|Actinobacteria,2NEZI@228398|Streptacidiphilus 201174|Actinobacteria L DnaB-like helicase N terminal domain dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_1591830_2 391625.PPSIR1_35667 3.6e-37 131.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,42SCQ@68525|delta/epsilon subdivisions,2WPZQ@28221|Deltaproteobacteria,2YX0Q@29|Myxococcales 28221|Deltaproteobacteria J binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_131770_1 472759.Nhal_3081 1.5e-64 224.0 COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1X042@135613|Chromatiales 135613|Chromatiales Q Phosphate acyltransferases - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C,Acyltransferase,PP-binding k59_1647279_1 436308.Nmar_0808 2.17e-65 207.0 COG0469@1|root,arCOG04071@2157|Archaea,41SHB@651137|Thaumarchaeota 651137|Thaumarchaeota J Ribosomal protein L4 - - - ko:K02930 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_1647279_2 1229909.NSED_04475 1.75e-11 59.3 COG0089@1|root,arCOG04072@2157|Archaea,41SS4@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome rpl23 - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_1647280_2 1410618.JNKI01000001_gene1411 3.17e-19 87.4 COG2968@1|root,COG2968@2|Bacteria,1VB7C@1239|Firmicutes,4H56P@909932|Negativicutes 909932|Negativicutes S Psort location Periplasmic, score - - - ko:K09807 - - - - ko00000 - - - SIMPL k59_1286622_1 366602.Caul_3858 7.21e-11 64.7 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria,2KFKV@204458|Caulobacterales 204458|Caulobacterales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_1382231_1 1354722.JQLS01000004_gene4233 4.63e-88 275.0 COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,2U39P@28211|Alphaproteobacteria 28211|Alphaproteobacteria I TIGRFAM methylmalonyl-CoA mutase, large subunit - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_1494102_1 1449357.JQLK01000001_gene902 3.15e-10 58.9 COG0125@1|root,COG0125@2|Bacteria,1WK3U@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_1286632_1 420324.KI912061_gene6197 3.48e-61 214.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,1JR57@119045|Methylobacteriaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,Abhydrolase_1,Guanylate_cyc,TPR_4 k59_444533_1 519989.ECTPHS_10791 4.36e-40 147.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1WXJT@135613|Chromatiales 135613|Chromatiales F Belongs to the 5'-nucleotidase family - - - ko:K17224 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - 5_nucleotid_C k59_233559_1 243159.AFE_0520 1.81e-101 318.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,2NBTK@225057|Acidithiobacillales 225057|Acidithiobacillales O ATP-dependent Clp protease, ATP-binding subunit clpA clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1440405_1 582744.Msip34_0003 2.18e-101 317.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,2KKEJ@206350|Nitrosomonadales 206350|Nitrosomonadales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1286635_1 1123393.KB891331_gene2851 1.64e-31 125.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,1KSVV@119069|Hydrogenophilales 119069|Hydrogenophilales T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA k59_286690_1 580332.Slit_0530 2.08e-73 243.0 COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria 28216|Betaproteobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,Pkinase k59_338914_1 1121918.ARWE01000001_gene2929 1.06e-105 341.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,43SCA@69541|Desulfuromonadales 28221|Deltaproteobacteria L TRCF mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_131809_1 321327.CYA_0440 3.53e-22 98.6 COG4671@1|root,COG4671@2|Bacteria,1G142@1117|Cyanobacteria,1GYRP@1129|Synechococcus 1117|Cyanobacteria S Glycosyl Transferase - - - - - - - - - - - - - k59_1494123_1 330214.NIDE1440 3.64e-53 181.0 COG4948@1|root,COG4948@2|Bacteria 2|Bacteria M carboxylic acid catabolic process - - 5.1.1.20,5.5.1.1 ko:K01856,ko:K19802 ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220 M00568 R05300,R05390,R06989,R08116,R09229,R10938 RC00903,RC01038,RC01108,RC01321,RC01356,RC03309 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_705755_1 268746.Q58MK7_BPPRM 2.91e-69 225.0 4QAKZ@10239|Viruses,4QUSW@35237|dsDNA viruses no RNA stage,4QPYH@28883|Caudovirales,4QIYN@10662|Myoviridae 10662|Myoviridae S exonuclease activity - - - - - - - - - - - - - k59_705755_2 268746.Q58MK8_BPPRM 1.85e-38 130.0 4QBEN@10239|Viruses,4QW43@35237|dsDNA viruses no RNA stage,4QPWZ@28883|Caudovirales,4QI7M@10662|Myoviridae 10662|Myoviridae S Protein of unknown function (DUF3110) - - - - - - - - - - - - - k59_705755_3 268746.Q58MK9_BPPRM 4.52e-11 63.2 4QAIK@10239|Viruses,4QUPH@35237|dsDNA viruses no RNA stage,4QPEB@28883|Caudovirales,4QHXI@10662|Myoviridae 10662|Myoviridae S hydrolase activity - - - - - - - - - - - - - k59_1230984_1 1216966.BAUC01000013_gene316 8.25e-08 58.9 COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,1RR49@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid panE GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008677,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0036094,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_1286665_1 1121935.AQXX01000144_gene4417 8.66e-70 221.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,1RQN1@1236|Gammaproteobacteria,1XHGV@135619|Oceanospirillales 135619|Oceanospirillales S C4-dicarboxylate ABC transporter substrate-binding protein - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_964463_2 706587.Desti_0127 8.09e-08 60.1 COG0454@1|root,COG0456@2|Bacteria,1Q6NJ@1224|Proteobacteria,433FJ@68525|delta/epsilon subdivisions,2WX7D@28221|Deltaproteobacteria 28221|Deltaproteobacteria K acetyltransferase - - - - - - - - - - - - - k59_705760_2 243231.GSU0256 1.39e-19 86.7 COG2703@1|root,COG2703@2|Bacteria,1N8CP@1224|Proteobacteria,42NR3@68525|delta/epsilon subdivisions 1224|Proteobacteria P Hemerythrin HHE cation binding domain - - - ko:K07216 - - - - ko00000 - - - Hemerythrin k59_1440435_1 1123072.AUDH01000003_gene779 2.38e-71 230.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2U1QF@28211|Alphaproteobacteria,2JVYJ@204441|Rhodospirillales 204441|Rhodospirillales C Fumarate reductase flavoprotein C-term - - - - - - - - - - - - FAD_binding_2,Succ_DH_flav_C k59_1440435_2 713586.KB900536_gene705 6.78e-110 320.0 COG1838@1|root,COG1838@2|Bacteria,1MVNG@1224|Proteobacteria,1RMT4@1236|Gammaproteobacteria 1236|Gammaproteobacteria C )-tartrate dehydratase ttdB GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896 4.2.1.32 ko:K03780 ko00630,map00630 - R00339 RC01382 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_2920 Fumerase_C k59_1440435_3 1121861.KB899918_gene3217 2.73e-94 282.0 COG1951@1|root,COG1951@2|Bacteria,1MW8J@1224|Proteobacteria,2U0X2@28211|Alphaproteobacteria,2JWAC@204441|Rhodospirillales 204441|Rhodospirillales C Fumarate hydratase (Fumerase) - - - - - - - - - - - - Fumerase k59_500752_1 1229909.NSED_06925 4.59e-120 345.0 COG1095@1|root,arCOG00675@2157|Archaea,41SGF@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-directed RNA polymerase - - 2.7.7.6 ko:K03049 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - S1,SHS2_Rpb7-N k59_705763_2 648885.KB316282_gene2100 6.6e-71 236.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,1JSTD@119045|Methylobacteriaceae 28211|Alphaproteobacteria T Histidine kinase fixL - 2.7.13.3 ko:K14986 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,MEDS,PAS,PAS_3,PAS_9 k59_599490_1 290400.Jann_0791 5.15e-10 62.0 COG1525@1|root,COG1525@2|Bacteria,1PRMI@1224|Proteobacteria,2UA9S@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Staphylococcal nuclease homologue - - - - - - - - - - - - SNase k59_599490_3 998674.ATTE01000001_gene901 8.14e-42 142.0 COG2259@1|root,COG2259@2|Bacteria,1N06A@1224|Proteobacteria,1S92U@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane - - - ko:K15977 - - - - ko00000 - - - DoxX k59_1123004_1 717605.Theco_0499 4.2e-23 102.0 COG3677@1|root,COG3677@2|Bacteria,1V800@1239|Firmicutes,4IRED@91061|Bacilli,276R8@186822|Paenibacillaceae 91061|Bacilli L Transposase zinc-ribbon domain - - - - - - - - - - - - Zn_Tnp_IS1595 k59_1327642_1 1123240.ATVO01000006_gene1400 3.11e-30 119.0 COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,2TUI2@28211|Alphaproteobacteria 28211|Alphaproteobacteria EQ L-aminopeptidase D-esterase - - - - - - - - - - - - Peptidase_S58 k59_827255_1 1041930.Mtc_1504 5.87e-25 107.0 COG3808@1|root,arCOG04949@2157|Archaea,2XTDB@28890|Euryarchaeota,2N98C@224756|Methanomicrobia 224756|Methanomicrobia C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_348219_1 870187.Thini_2559 3.41e-08 54.7 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,45ZW2@72273|Thiotrichales 72273|Thiotrichales G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_348219_2 713586.KB900536_gene1317 2.52e-91 276.0 COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RQ57@1236|Gammaproteobacteria,1WZYG@135613|Chromatiales 135613|Chromatiales G Fructose-bisphosphate aldolase class-I - - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic k59_923164_1 1089553.Tph_c20790 2.85e-23 102.0 COG0558@1|root,COG1213@1|root,COG0558@2|Bacteria,COG1213@2|Bacteria,1V33I@1239|Firmicutes 1239|Firmicutes IM Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.7.74,2.7.8.34 ko:K07281,ko:K07291 ko00562,map00562 - R09669,R09670 RC00002,RC00078 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf,NTP_transf_3 k59_16022_2 1415780.JPOG01000001_gene998 5.45e-43 158.0 COG0477@1|root,COG2814@2|Bacteria,1RCII@1224|Proteobacteria 1224|Proteobacteria EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_184194_1 146922.JOFU01000025_gene4632 5e-43 150.0 COG1309@1|root,COG1309@2|Bacteria,2GK0V@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - TetR_N k59_348220_2 1177154.Y5S_02187 3.92e-20 90.9 COG1273@1|root,COG1273@2|Bacteria,1MWCU@1224|Proteobacteria,1RYQ0@1236|Gammaproteobacteria,1XK92@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF3426) - - - - - - - - - - - - DUF3426,zinc_ribbon_4,zinc_ribbon_5 k59_1079717_1 290397.Adeh_2791 1.69e-25 110.0 COG0493@1|root,COG0543@1|root,COG1633@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,COG1633@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WKB4@28221|Deltaproteobacteria,2YTUD@29|Myxococcales 28221|Deltaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_827271_1 1121918.ARWE01000001_gene1768 4.88e-70 233.0 COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,43U7R@69541|Desulfuromonadales 28221|Deltaproteobacteria H Methionine synthase B12-binding module cap domain protein metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_141007_1 330214.NIDE0407 2.04e-108 335.0 COG0155@1|root,COG0425@1|root,COG0155@2|Bacteria,COG0425@2|Bacteria,3J11D@40117|Nitrospirae 40117|Nitrospirae C Nitrite and sulphite reductase 4Fe-4S domain - - 1.7.1.15,1.8.7.1 ko:K00362,ko:K00392 ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120 M00176,M00530 R00787,R00859,R03600 RC00065,RC00176 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_713394_2 1088868.CIN_10870 4.84e-05 47.0 COG0346@1|root,COG0346@2|Bacteria,1RH8G@1224|Proteobacteria,2U9BR@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0346 Lactoylglutathione lyase and related lyases - - - - - - - - - - - - Glyoxalase k59_1177646_1 1131266.ARWQ01000008_gene320 7.93e-90 276.0 COG0044@1|root,arCOG00689@2157|Archaea,41S8A@651137|Thaumarchaeota 651137|Thaumarchaeota F Amidohydrolase family - - 3.5.2.2 ko:K01464 ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100 M00046 R02269,R03055,R08227 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Amidohydro_1 k59_241308_1 1110502.TMO_1556 5.06e-34 134.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,2JP8R@204441|Rhodospirillales 204441|Rhodospirillales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1024377_2 143224.JQMD01000002_gene1737 6.74e-49 184.0 COG3119@1|root,COG3408@1|root,COG3119@2|Bacteria,COG3408@2|Bacteria,4NHH7@976|Bacteroidetes,1HX4R@117743|Flavobacteriia 976|Bacteroidetes P arylsulfatase a - - - - - - - - - - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,DUF4976,Sulfatase k59_1504729_1 1235835.C814_01159 1.08e-23 105.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,3WGFC@541000|Ruminococcaceae 186801|Clostridia KL SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N,SNF2_assoc,SWIM k59_1504734_1 35128.Thapsdraft1267 1.89e-128 400.0 COG0085@1|root,KOG0214@2759|Eukaryota,2XEM3@2836|Bacillariophyta 2836|Bacillariophyta K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates - GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0030880,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:1902494,GO:1990234 - - - - - - - - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1240244_1 754476.Q7A_2224 5.42e-132 402.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,45ZRC@72273|Thiotrichales 72273|Thiotrichales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1598574_1 1121468.AUBR01000099_gene3089 2.76e-45 153.0 2CDFK@1|root,2Z8BH@2|Bacteria,1V43D@1239|Firmicutes,24KG0@186801|Clostridia 186801|Clostridia H DNA N-6-adenine-methyltransferase - - - - - - - - - - - - Dam k59_141029_1 797210.Halxa_2356 2.77e-05 53.5 COG3119@1|root,arCOG02785@2157|Archaea,2XWAF@28890|Euryarchaeota,23UMB@183963|Halobacteria 183963|Halobacteria P COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - Sulfatase k59_827307_1 485913.Krac_11077 1.36e-43 152.0 COG2008@1|root,COG2008@2|Bacteria,2G7UV@200795|Chloroflexi 200795|Chloroflexi E Beta-eliminating lyase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_1598577_1 945713.IALB_1844 1.74e-48 166.0 COG2025@1|root,COG2025@2|Bacteria 2|Bacteria C fatty acid beta-oxidation using acyl-CoA dehydrogenase etfA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_1658022_1 156889.Mmc1_0972 2.9e-39 150.0 COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria 2|Bacteria L PD-(D/E)XK nuclease superfamily addB - 3.1.11.5,3.6.4.12 ko:K01144,ko:K02259,ko:K16899 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko01000,ko03029,ko03400 3.D.4.4 - - PDDEXK_1 k59_1333880_2 436308.Nmar_0865 5.1e-88 272.0 COG0436@1|root,arCOG01130@2157|Archaea 2157|Archaea E PFAM Aminotransferase class I and II - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_827340_1 671143.DAMO_0752 1.93e-21 91.3 COG0638@1|root,COG0638@2|Bacteria,2NQRX@2323|unclassified Bacteria 2|Bacteria O Proteasome subunit - - 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome k59_827340_2 330214.NIDE3054 2.59e-56 186.0 COG0638@1|root,COG0638@2|Bacteria 2|Bacteria O Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine pafA GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 ko:K13571 - M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 - - - Pup_ligase k59_1024416_1 1469245.JFBG01000019_gene1173 4.95e-07 52.4 COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,1RP39@1236|Gammaproteobacteria 1236|Gammaproteobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_1024416_2 420324.KI911972_gene3020 2.88e-18 82.4 COG2518@1|root,COG2518@2|Bacteria,1R9HH@1224|Proteobacteria,2U4M1@28211|Alphaproteobacteria,1JZ76@119045|Methylobacteriaceae 28211|Alphaproteobacteria O Ribosomal RNA adenine dimethylase pcm3 - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_1131841_1 595537.Varpa_5685 5.29e-139 404.0 COG0604@1|root,COG0604@2|Bacteria,1MW2V@1224|Proteobacteria,2VMBC@28216|Betaproteobacteria,4AH4B@80864|Comamonadaceae 28216|Betaproteobacteria C Alcohol dehydrogenase groes - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_zinc_N k59_348302_2 1203554.HMPREF1476_02436 1.79e-25 97.4 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2VSVX@28216|Betaproteobacteria,4PR4K@995019|Sutterellaceae 28216|Betaproteobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_827347_1 1205680.CAKO01000029_gene5206 4.04e-50 171.0 COG0346@1|root,COG0346@2|Bacteria,1MW8Z@1224|Proteobacteria,2TS64@28211|Alphaproteobacteria 28211|Alphaproteobacteria E lactoylglutathione lyase activity MA20_40050 - - - - - - - - - - - Glyoxalase_3 k59_1131848_2 1182590.BN5_00189 1.14e-32 123.0 COG3436@1|root,COG3436@2|Bacteria,1MYAC@1224|Proteobacteria,1T2KH@1236|Gammaproteobacteria,1YM11@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L Transposase and inactivated derivatives - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_971991_2 748449.Halha_1645 1.05e-12 69.3 COG1757@1|root,COG1757@2|Bacteria,1TP8A@1239|Firmicutes,247V4@186801|Clostridia,3WA9C@53433|Halanaerobiales 186801|Clostridia C PFAM Na H antiporter - - - - - - - - - - - - Na_H_antiporter k59_141078_1 268746.Q58MM3_BPPRM 3.46e-143 419.0 4QBAK@10239|Viruses,4QY34@35237|dsDNA viruses no RNA stage,4QQBQ@28883|Caudovirales,4QIQI@10662|Myoviridae 10662|Myoviridae S Bacteriophage T4-like capsid assembly protein (Gp20) - GO:0005575,GO:0019012 - - - - - - - - - - - k59_1333904_1 870187.Thini_4374 2.84e-57 190.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,45ZWB@72273|Thiotrichales 72273|Thiotrichales G Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides nagZ - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_1539097_1 1502851.FG93_00182 8.16e-55 204.0 COG0642@1|root,COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1 k59_348320_1 1120956.JHZK01000001_gene3354 3.58e-59 191.0 COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,2TU33@28211|Alphaproteobacteria,1JPWV@119043|Rhodobiaceae 28211|Alphaproteobacteria H PBP superfamily domain tupA - - ko:K05772 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - PBP_like_2 k59_1024435_1 1123376.AUIU01000013_gene1830 9.79e-27 106.0 COG1451@1|root,COG1451@2|Bacteria,3J1DJ@40117|Nitrospirae 40117|Nitrospirae S Protein of unknown function DUF45 - - - ko:K07043 - - - - ko00000 - - - DUF45 k59_296171_1 1026882.MAMP_00068 6.02e-60 189.0 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL k59_184271_1 330214.NIDE4158 5.42e-104 325.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,3J0DP@40117|Nitrospirae 40117|Nitrospirae L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A k59_1024436_2 1249627.D779_3015 3.21e-24 97.1 COG1846@1|root,COG1846@2|Bacteria,1RF8X@1224|Proteobacteria,1S4RW@1236|Gammaproteobacteria,1WZMS@135613|Chromatiales 135613|Chromatiales K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 k59_399321_1 1123258.AQXZ01000012_gene2212 1.29e-19 92.4 COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4FVIP@85025|Nocardiaceae 201174|Actinobacteria C FAD binding domain - - - - - - - - - - - - BBE,FAD_binding_4 k59_1447945_1 1453501.JELR01000002_gene1510 1.1e-85 268.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,4646Q@72275|Alteromonadaceae 1236|Gammaproteobacteria F COG0138 AICAR transformylase IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) purH GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - iEcHS_1320.EcHS_A4240,iPC815.YPO3728 AICARFT_IMPCHas,MGS k59_1539106_2 68194.JNXR01000003_gene3056 9.68e-36 135.0 COG1960@1|root,COG1960@2|Bacteria,2GJHM@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase aidB - - ko:K09456 - - - - ko00000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_555563_4 444860.E3SJF8_9CAUD 2.48e-21 89.0 4QAUS@10239|Viruses,4QURX@35237|dsDNA viruses no RNA stage,4QQ2S@28883|Caudovirales 28883|Caudovirales S flavin adenine dinucleotide binding - - - - - - - - - - - - - k59_555564_1 330214.NIDE4029 9.35e-38 127.0 COG2975@1|root,COG2975@2|Bacteria,3J1CR@40117|Nitrospirae 40117|Nitrospirae S Iron-sulphur cluster assembly - - - - - - - - - - - - Fe-S_assembly k59_555564_2 330214.NIDE4028 1.71e-24 102.0 COG0443@1|root,COG0443@2|Bacteria,3J0YD@40117|Nitrospirae 40117|Nitrospirae O Hsp70 protein hscA - - ko:K04043,ko:K04044 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33,1.A.33.1 - - HSP70 k59_1334928_1 404589.Anae109_1866 5.99e-37 137.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,42QST@68525|delta/epsilon subdivisions,2WMN8@28221|Deltaproteobacteria,2YZ74@29|Myxococcales 28221|Deltaproteobacteria S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_185324_1 395493.BegalDRAFT_1319 9.9e-93 288.0 COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,1RQPC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S von willebrand factor, type A yfbK - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - DUF3520,VWA,vWF_A k59_349677_1 639030.JHVA01000001_gene944 2.13e-70 226.0 COG0015@1|root,COG0015@2|Bacteria,3Y2QW@57723|Acidobacteria,2JIAC@204432|Acidobacteriia 204432|Acidobacteriia F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily - - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_973247_2 1121440.AUMA01000003_gene2990 3.93e-30 113.0 COG1259@1|root,COG1259@2|Bacteria,1RFFV@1224|Proteobacteria,42SCI@68525|delta/epsilon subdivisions,2WPWT@28221|Deltaproteobacteria,2M8KC@213115|Desulfovibrionales 28221|Deltaproteobacteria S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase k59_1334936_1 1454004.AW11_02326 2.76e-29 114.0 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2VHTB@28216|Betaproteobacteria,1KQP3@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_1334937_2 436308.Nmar_0252 2.33e-32 118.0 COG1056@1|root,arCOG00972@2157|Archaea,41SHQ@651137|Thaumarchaeota 651137|Thaumarchaeota H Nicotinamide-nucleotide adenylyltransferase - - - - - - - - - - - - - k59_555581_1 857087.Metme_1515 2.09e-15 75.1 COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,1RPDG@1236|Gammaproteobacteria,1XE57@135618|Methylococcales 135618|Methylococcales G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_555581_2 1249627.D779_0831 7.26e-08 54.3 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1WWAD@135613|Chromatiales 135613|Chromatiales G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_455379_1 595460.RRSWK_04938 7.63e-26 106.0 COG0624@1|root,COG0624@2|Bacteria,2J1RT@203682|Planctomycetes 203682|Planctomycetes E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_1448960_1 338966.Ppro_2303 1.71e-71 239.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria,43TCH@69541|Desulfuromonadales 28221|Deltaproteobacteria J TIGRFAM phenylalanyl-tRNA synthetase, beta subunit pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_1390412_1 1408418.JNJH01000024_gene10 1.67e-15 78.2 COG3240@1|root,COG3240@2|Bacteria,1MWDI@1224|Proteobacteria,2U65S@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG3240 Phospholipase lecithinase hemolysin - - - - - - - - - - - - Autotransporter,Lipase_GDSL,Lipase_GDSL_2 k59_1081207_2 1038859.AXAU01000003_gene6200 2.63e-86 266.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,3JW7Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_555599_1 1158762.KB898050_gene812 1.46e-133 389.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1WW9F@135613|Chromatiales 135613|Chromatiales E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1178785_1 1210045.ALNP01000005_gene3641 9.42e-48 181.0 COG1033@1|root,COG2409@1|root,COG1033@2|Bacteria,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria 201174|Actinobacteria F Drug exporters of the RND superfamily - - - ko:K06994 - - - - ko00000 - - - MMPL k59_1659852_1 56780.SYN_01427 1.07e-55 190.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42PIH@68525|delta/epsilon subdivisions,2WJH2@28221|Deltaproteobacteria,2MRI5@213462|Syntrophobacterales 28221|Deltaproteobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_349716_1 1335757.SPICUR_08155 2.76e-08 54.3 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RMAX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_349716_2 395493.BegalDRAFT_2504 7.51e-115 341.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,461J8@72273|Thiotrichales 72273|Thiotrichales I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1025667_1 1168059.KB899087_gene3003 1.43e-15 72.8 COG2963@1|root,COG2963@2|Bacteria,1MZ5C@1224|Proteobacteria,2UCUC@28211|Alphaproteobacteria,3F1QD@335928|Xanthobacteraceae 28211|Alphaproteobacteria L PFAM transposase IS3 IS911 family protein - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_1025667_2 378806.STAUR_7364 1.31e-84 262.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,42M98@68525|delta/epsilon subdivisions,2WMKB@28221|Deltaproteobacteria,2YXV7@29|Myxococcales 28221|Deltaproteobacteria L HTH-like domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_249978_1 671143.DAMO_0752 2.46e-67 210.0 COG0638@1|root,COG0638@2|Bacteria,2NQRX@2323|unclassified Bacteria 2|Bacteria O Proteasome subunit - - 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome k59_103806_1 1198452.Jab_2c01520 5.42e-111 342.0 COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,4736W@75682|Oxalobacteraceae 28216|Betaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,HAMP k59_1185019_1 1232437.KL661966_gene3144 2.52e-40 140.0 2C477@1|root,32RDF@2|Bacteria,1RKW1@1224|Proteobacteria,42SWN@68525|delta/epsilon subdivisions,2WP88@28221|Deltaproteobacteria,2MNB4@213118|Desulfobacterales 28221|Deltaproteobacteria S DGC domain - - - - - - - - - - - - DGC k59_1396689_1 933262.AXAM01000036_gene2178 2.5e-10 65.9 COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,43B26@68525|delta/epsilon subdivisions,2X6G6@28221|Deltaproteobacteria,2MKC2@213118|Desulfobacterales 28221|Deltaproteobacteria S MmgE/PrpD family - - - - - - - - - - - - MmgE_PrpD k59_1140936_1 1121272.KB903249_gene1700 5.83e-06 53.9 COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2GJYH@201174|Actinobacteria,4DBUI@85008|Micromonosporales 201174|Actinobacteria M Peptidase inhibitor I9 - - - - - - - - - - - - Inhibitor_I9,P_proprotein,Peptidase_S8 k59_1670287_1 1223410.KN050846_gene2460 3.94e-24 106.0 COG2304@1|root,COG2911@1|root,COG2304@2|Bacteria,COG2911@2|Bacteria,4PKD0@976|Bacteroidetes,1HWKJ@117743|Flavobacteriia 976|Bacteroidetes U Large extracellular alpha-helical protein - - - - - - - - - - - - CHU_C,HYR,LRR_adjacent k59_771413_1 164757.Mjls_4433 6.9e-44 155.0 COG0596@1|root,COG0596@2|Bacteria 2|Bacteria S hydrolase activity, acting on ester bonds - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_876625_1 1123023.JIAI01000001_gene6646 3.86e-94 288.0 COG4638@1|root,COG4638@2|Bacteria,2HGJ1@201174|Actinobacteria,4ECUG@85010|Pseudonocardiales 201174|Actinobacteria P Ring hydroxylating alpha subunit (catalytic domain) - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_305251_1 1122604.JONR01000003_gene1505 4.2e-33 131.0 COG4642@1|root,COG4642@2|Bacteria,1P07C@1224|Proteobacteria,1T4GU@1236|Gammaproteobacteria,1XDAQ@135614|Xanthomonadales 135614|Xanthomonadales S Peptidase C13 family - - - - - - - - - - - - Peptidase_C13 k59_614843_1 2880.D8LKE0 1.58e-40 147.0 COG0492@1|root,KOG0404@2759|Eukaryota 2759|Eukaryota O thioredoxin-disulfide reductase activity - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Thioredoxin k59_103839_1 472759.Nhal_0798 6.86e-47 174.0 COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,1S4M3@1236|Gammaproteobacteria,1WWN6@135613|Chromatiales 135613|Chromatiales E Extracellular solute-binding protein, family 5 - - - - - - - - - - - - SBP_bac_5 k59_1185055_1 661478.OP10G_0685 7.51e-12 65.1 COG0329@1|root,COG0329@2|Bacteria 2|Bacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) - - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - - k59_1185055_2 1385517.N800_13455 1.77e-08 55.1 COG3360@1|root,COG3360@2|Bacteria,1N6UT@1224|Proteobacteria,1SCF7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Flavin and coenzyme A sequestration protein dodecin - - - ko:K09165 - - - - ko00000 - - - Dodecin k59_771433_1 1249627.D779_4075 3.18e-06 46.6 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria,1WYAT@135613|Chromatiales 135613|Chromatiales J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_562960_1 928724.SacglDRAFT_02763 5.53e-74 238.0 COG0657@1|root,COG0657@2|Bacteria,2GTEV@201174|Actinobacteria,4DZK5@85010|Pseudonocardiales 201174|Actinobacteria I Alpha beta hydrolase lipM - - - - - - - - - - - Abhydrolase_3 k59_978722_1 472759.Nhal_2900 1.81e-88 284.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales 135613|Chromatiales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_1248247_1 264198.Reut_C6399 6.97e-64 214.0 COG0665@1|root,COG0665@2|Bacteria,1Q38Q@1224|Proteobacteria,2W11K@28216|Betaproteobacteria,1KGZK@119060|Burkholderiaceae 28216|Betaproteobacteria E FAD binding domain - - - - - - - - - - - - DAO k59_932402_1 1123507.ATVQ01000001_gene2088 9.1e-06 48.9 COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,1W8JD@1268|Micrococcaceae 201174|Actinobacteria G Belongs to the HpcH HpaI aldolase family citE_2 - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_250065_1 670487.Ocepr_0388 7.44e-49 166.0 COG1171@1|root,COG1171@2|Bacteria,1WI3F@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1141029_1 1238182.C882_3667 1.22e-83 268.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,2TW04@28211|Alphaproteobacteria,2JQYW@204441|Rhodospirillales 204441|Rhodospirillales KT Domain present in phytochromes and cGMP-specific phosphodiesterases. nifA - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_978734_1 268746.Q58MG8_BPPRM 9.04e-111 330.0 4QAWG@10239|Viruses,4QV6X@35237|dsDNA viruses no RNA stage,4QPII@28883|Caudovirales,4QI76@10662|Myoviridae 10662|Myoviridae S DNA helicase activity - - - - - - - - - - - - - k59_103914_1 1051632.TPY_0619 6.96e-46 166.0 COG1530@1|root,COG1530@2|Bacteria,1TQS4@1239|Firmicutes,247QV@186801|Clostridia 186801|Clostridia J ribonuclease, Rne Rng family rng - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1,TRAM k59_932422_1 765913.ThidrDRAFT_0916 6.14e-74 242.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1WWXP@135613|Chromatiales 135613|Chromatiales J small GTP-binding protein - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_1088772_1 671143.DAMO_1147 1.61e-41 141.0 COG0315@1|root,COG0315@2|Bacteria,2NPNE@2323|unclassified Bacteria 2|Bacteria H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC GO:0002682,GO:0002683,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0031347,GO:0031348,GO:0034214,GO:0035821,GO:0040007,GO:0042802,GO:0043170,GO:0043207,GO:0043545,GO:0043933,GO:0044003,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0046483,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0061799,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0075136,GO:0080134,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC k59_1088772_2 671143.DAMO_1148 1.26e-55 187.0 COG0123@1|root,COG0123@2|Bacteria,2NP8V@2323|unclassified Bacteria 2|Bacteria BQ Histone deacetylase domain acuC - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl k59_357317_2 234267.Acid_4707 1.09e-11 65.1 COG0697@1|root,COG0697@2|Bacteria,3Y570@57723|Acidobacteria 57723|Acidobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_150384_1 479431.Namu_0877 9.89e-29 110.0 COG1028@1|root,COG1028@2|Bacteria,2HEWC@201174|Actinobacteria,4EV16@85013|Frankiales 201174|Actinobacteria IQ KR domain - - - ko:K07535 ko00362,ko01120,ko01220,map00362,map01120,map01220 M00540 R05582 RC00154 ko00000,ko00001,ko00002,ko01000 - - - adh_short_C2 k59_150384_2 1128421.JAGA01000003_gene3323 7.65e-26 107.0 COG1472@1|root,COG1472@2|Bacteria,2NNZB@2323|unclassified Bacteria 2|Bacteria G Glycoside hydrolase family 3 domain protein bxlA - 3.2.1.21 ko:K05349,ko:K17641 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_409636_1 572265.HDEF_1323 3.72e-41 142.0 COG2094@1|root,COG2094@2|Bacteria,1RE0A@1224|Proteobacteria,1S9CM@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the DNA glycosylase MPG family - GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 ko:K03652 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Pur_DNA_glyco k59_1034390_1 498761.HM1_2322 2.94e-41 154.0 COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia 186801|Clostridia J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_1606309_1 1122207.MUS1_15595 1.16e-06 53.1 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1XI2V@135619|Oceanospirillales 135619|Oceanospirillales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) mltD - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_1606309_2 317025.Tcr_0070 3.71e-08 55.1 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,45ZUR@72273|Thiotrichales 72273|Thiotrichales IQ Phosphate acyltransferases - - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_1398294_1 1535422.ND16A_2019 1.05e-05 53.5 COG4424@1|root,COG4424@2|Bacteria,1QVF4@1224|Proteobacteria,1S30Z@1236|Gammaproteobacteria,2Q7EC@267889|Colwelliaceae 1236|Gammaproteobacteria S Sulfotransferase domain - - - - - - - - - - - - SEC-C,Sulfotransfer_3 k59_409657_1 1429916.X566_07565 7.55e-06 51.6 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2TS39@28211|Alphaproteobacteria,3JS8W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria V HlyD membrane-fusion protein of T1SS - - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1342853_1 472759.Nhal_0327 3.29e-89 281.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1WWBU@135613|Chromatiales 135613|Chromatiales G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) - - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_1249582_1 1448389.BAVQ01000005_gene3146 1.36e-27 115.0 COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria 201174|Actinobacteria IQ synthetase fadD19 GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009605,GO:0009607,GO:0009987,GO:0015645,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019752,GO:0030312,GO:0032787,GO:0042546,GO:0042579,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051087,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071554,GO:0071704,GO:0071766,GO:0071840,GO:0071944,GO:0075136,GO:1901576 6.2.1.42 ko:K18688 - - - - ko00000,ko01000 - - - AMP-binding,AMP-binding_C k59_1249603_1 1245469.S58_70400 1.42e-68 231.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TQMV@28211|Alphaproteobacteria,3JSPM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G PQQ-like domain gcd GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 k59_980299_1 591159.ACEZ01000097_gene5812 2.36e-07 50.8 COG1141@1|root,COG1141@2|Bacteria,2IR4H@201174|Actinobacteria 201174|Actinobacteria C 4Fe-4S single cluster domain - - - ko:K05337 - - - - ko00000 - - - Fer4_13,Fer4_15 k59_1549333_1 2340.JV46_12030 4.65e-09 58.5 COG3471@1|root,COG3471@2|Bacteria,1MZA2@1224|Proteobacteria,1S793@1236|Gammaproteobacteria,1JAI2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF541) Z012_10940 - - - - - - - - - - - SIMPL k59_1142905_1 1493510.A0A0E3G5G3_9CAUD 3.84e-97 305.0 4QAXQ@10239|Viruses,4QRFY@28883|Caudovirales,4QI6A@10662|Myoviridae 10662|Myoviridae S Ribonucleotide reductase, barrel domain - - - - - - - - - - - - - k59_1342892_1 1453501.JELR01000002_gene1472 2.18e-44 164.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464X3@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1249612_1 553385.JEMF01000016_gene418 4.12e-26 102.0 COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria,1XIY0@135619|Oceanospirillales 135619|Oceanospirillales L Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH - - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX k59_1249612_2 1255043.TVNIR_3451 2.42e-64 203.0 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1WXJF@135613|Chromatiales 135613|Chromatiales E HAD-superfamily subfamily IB hydrolase, TIGR01490 - - - - - - - - - - - - HAD k59_1606342_1 765420.OSCT_2372 7.35e-05 51.2 COG2849@1|root,COG5492@1|root,COG2849@2|Bacteria,COG5492@2|Bacteria 2|Bacteria N domain, Protein - - 2.4.1.52 ko:K00712,ko:K21471 - - - - ko00000,ko01000,ko01002,ko01003,ko01011 - GT4 - Big_2,MORN_2,SLH k59_1398346_1 1121091.AUMP01000004_gene2351 4.96e-22 97.1 COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,4HC85@91061|Bacilli 91061|Bacilli M plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins prsA - 5.2.1.8 ko:K01802,ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3,SurA_N_3 k59_616683_1 710686.Mycsm_04797 1.1e-19 95.1 COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,233RN@1762|Mycobacteriaceae 201174|Actinobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_933944_1 330214.NIDE3222 1.79e-88 268.0 COG0123@1|root,COG0123@2|Bacteria,3J0P2@40117|Nitrospirae 40117|Nitrospirae BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl k59_933948_1 713587.THITH_14560 2.44e-24 98.6 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,1WWVC@135613|Chromatiales 135613|Chromatiales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_933948_2 314287.GB2207_10601 1.29e-16 81.6 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1J4WE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain degS GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564 - ko:K04691,ko:K04772 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Trypsin_2 k59_1549369_1 926550.CLDAP_07170 1.67e-11 70.9 COG3420@1|root,COG3420@2|Bacteria 2|Bacteria P alginic acid biosynthetic process nosD - - ko:K07218 - - - - ko00000 - - - NosD k59_1090445_1 1042375.AFPL01000038_gene1592 4.47e-46 156.0 COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,1RMWJ@1236|Gammaproteobacteria,468SR@72275|Alteromonadaceae 1236|Gammaproteobacteria G Belongs to the HpcH HpaI aldolase family rhmA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016151,GO:0016829,GO:0016830,GO:0016832,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0071704 4.1.2.52,4.1.2.53 ko:K02510,ko:K12660 ko00051,ko00350,ko01120,map00051,map00350,map01120 - R01645,R01647,R02261 RC00307,RC00435,RC00572,RC00574,RC03057 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_2049 HpcH_HpaI k59_1090445_2 675806.VII_002382 5.03e-20 86.3 COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,1RMZ4@1236|Gammaproteobacteria,1Y0ND@135623|Vibrionales 135623|Vibrionales Q hydratase - - - ko:K02509 ko00350,ko01120,map00350,map01120 - R04132,R06897 RC01615,RC02595 ko00000,ko00001,ko01000 - - - - k59_1342932_1 875328.JDM601_1154 8.39e-38 131.0 COG0251@1|root,COG0251@2|Bacteria,2IHYE@201174|Actinobacteria,239NC@1762|Mycobacteriaceae 201174|Actinobacteria J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_306834_1 1437448.AZRT01000143_gene2350 9.71e-56 181.0 COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2U1DA@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Putative transposase of IS4/5 family (DUF4096) - - - - - - - - - - - - DDE_Tnp_1,DUF4096 k59_878055_1 713586.KB900536_gene1841 9.25e-55 193.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_464301_1 1231241.Mc24_06653 5.08e-52 180.0 COG1641@1|root,COG1641@2|Bacteria 2|Bacteria H Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes larC - 4.99.1.12 ko:K06898,ko:K09121 - - - - ko00000,ko01000 - - - DUF111 k59_150502_1 322710.Avin_43480 9.98e-85 268.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360 - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1186725_1 436308.Nmar_1698 2.61e-170 487.0 COG0004@1|root,arCOG04397@2157|Archaea,41SY0@651137|Thaumarchaeota 651137|Thaumarchaeota P Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_772758_1 1168065.DOK_15159 1.3e-54 191.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1S096@1236|Gammaproteobacteria,1J7ZV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdopterin,Molydop_binding k59_464315_1 224911.27351247 6.83e-54 180.0 COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,2TTSG@28211|Alphaproteobacteria,3JRZP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Metallo-beta-lactamase superfamily - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - Lactamase_B k59_616731_1 1123371.ATXH01000026_gene137 4.79e-109 330.0 COG0527@1|root,COG0527@2|Bacteria,2GGWG@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Belongs to the aspartokinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_878067_1 1232437.KL662039_gene2066 5.29e-05 46.6 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,2MHWF@213118|Desulfobacterales 28221|Deltaproteobacteria U PFAM MotA TolQ ExbB proton channel aglX - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_1398420_1 582515.KR51_00031110 1.62e-20 99.0 COG0860@1|root,COG0860@2|Bacteria,1G008@1117|Cyanobacteria 1117|Cyanobacteria M N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3 k59_772771_1 631454.N177_0608 5.93e-07 51.6 COG0845@1|root,COG0845@2|Bacteria,1MVFN@1224|Proteobacteria,2TRSC@28211|Alphaproteobacteria,1JNK6@119043|Rhodobiaceae 28211|Alphaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - ko:K18990 - M00720 - - ko00000,ko00002,ko02000 2.A.6.2.30,8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_772771_2 395493.BegalDRAFT_2091 3.5e-52 184.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18989 - M00720 - - ko00000,ko00002,ko02000 2.A.6.2.30 - - ACR_tran k59_1606390_1 1493512.A0A0E3FB49_9CAUD 2.03e-39 152.0 4QH89@10239|Viruses,4QQRH@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_1034495_1 4432.XP_010255397.1 8.26e-19 92.4 COG0637@1|root,KOG2914@2759|Eukaryota,37NBR@33090|Viridiplantae,3G9N1@35493|Streptophyta 35493|Streptophyta S Haloacid dehalogenase-like hydrolase (HAD) superfamily protein - GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016310,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0018130,GO:0019538,GO:0034641,GO:0036211,GO:0042364,GO:0042578,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0043621,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HAD_2 k59_1186751_1 330214.NIDE4254 8.39e-138 400.0 COG0624@1|root,COG0624@2|Bacteria 2|Bacteria E succinyl-diaminopimelate desuccinylase activity - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_32564_1 330214.NIDE1094 1.62e-44 165.0 COG0577@1|root,COG0577@2|Bacteria,3J0Z3@40117|Nitrospirae 40117|Nitrospirae V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_32592_1 2002.JOEQ01000012_gene5790 4.16e-76 240.0 COG0183@1|root,COG0183@2|Bacteria,2GKFR@201174|Actinobacteria,4EHJE@85012|Streptosporangiales 201174|Actinobacteria I lipid-transfer protein ltp2 - - - - - - - - - - - Thiolase_N k59_32592_2 1240349.ANGC01000006_gene1378 1.74e-13 67.4 COG2030@1|root,COG2030@2|Bacteria,2IHT0@201174|Actinobacteria,4G26Q@85025|Nocardiaceae 201174|Actinobacteria I dehydratase - - - - - - - - - - - - MaoC_dehydratas k59_32612_2 1382306.JNIM01000001_gene129 2.94e-30 117.0 COG2386@1|root,COG2386@2|Bacteria,2G6TN@200795|Chloroflexi 200795|Chloroflexi O PFAM cytochrome c-type biogenesis protein CcmB ccmB - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB k59_32696_1 113395.AXAI01000004_gene4399 6.46e-28 120.0 COG4258@1|root,COG4258@2|Bacteria,1QW57@1224|Proteobacteria,2TSFU@28211|Alphaproteobacteria,3JU1T@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_32701_1 1384056.N787_12005 5.45e-88 278.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1X2Z8@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_32713_1 319225.Plut_0106 6.09e-17 75.9 COG2154@1|root,COG2154@2|Bacteria 2|Bacteria H pterin-4-alpha-carbinolamine dehydratase phhB GO:0003674,GO:0003824,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008124,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0034311,GO:0034312,GO:0034641,GO:0042558,GO:0042559,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a k59_32718_1 436308.Nmar_1231 8.99e-122 366.0 COG3808@1|root,arCOG04949@2157|Archaea,41SZG@651137|Thaumarchaeota 651137|Thaumarchaeota C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_32849_1 1121875.KB907553_gene17 5.1e-70 236.0 COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,1HXIG@117743|Flavobacteriia 976|Bacteroidetes G BNR Asp-box repeat - - - - - - - - - - - - Sortilin-Vps10 k59_32883_2 1255043.TVNIR_2961 1.45e-06 52.0 COG3258@1|root,COG3258@2|Bacteria,1MZJW@1224|Proteobacteria,1S2EF@1236|Gammaproteobacteria,1WY2H@135613|Chromatiales 135613|Chromatiales C Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365 k59_33011_2 330214.NIDE1009 7.69e-43 152.0 COG2385@1|root,COG2385@2|Bacteria,3J15K@40117|Nitrospirae 40117|Nitrospirae D Stage II sporulation protein - - - ko:K06381 - - - - ko00000 - - - SpoIID k59_33026_1 1343740.M271_13000 3.16e-09 60.1 COG3420@1|root,COG3420@2|Bacteria,2GNYS@201174|Actinobacteria 201174|Actinobacteria P Periplasmic copper-binding protein (NosD) - - - - - - - - - - - - Beta_helix k59_33134_1 1906.SFRA_20305 8.29e-34 130.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family gabD1 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009013,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_33136_1 754476.Q7A_878 1.97e-66 215.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,45ZPH@72273|Thiotrichales 72273|Thiotrichales H PFAM aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_105033_1 1279017.AQYJ01000026_gene315 7.09e-58 197.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,46499@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG0608 Single-stranded DNA-specific exonuclease recJ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_1306405_1 666509.RCA23_c18950 5.72e-40 142.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system potA - - ko:K02052 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - ABC_tran,TOBE_2 k59_784260_1 498761.HM1_3125 3.01e-08 51.6 2DSV3@1|root,33HII@2|Bacteria,1VQ64@1239|Firmicutes,24VWA@186801|Clostridia 186801|Clostridia S ORF located using Blastx - - - - - - - - - - - - - k59_650_1 1265313.HRUBRA_02356 1.24e-48 174.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1J5FP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain - - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_1097520_1 1278309.KB907099_gene2913 5.82e-30 124.0 COG2132@1|root,COG2132@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Parallel beta-helix repeats - - - - - - - - - - - - - k59_1254298_1 1255043.TVNIR_2196 1.24e-70 222.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1WXEN@135613|Chromatiales 135613|Chromatiales H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_1306416_1 550540.Fbal_0126 1.54e-35 130.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Stress-induced protein yicC GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575 - - - - - - - - - - DUF1732,YicC_N k59_1463208_1 592316.Pat9b_3862 6.74e-68 231.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,3VY59@53335|Pantoea 1236|Gammaproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_1358750_1 861299.J421_0446 8.44e-18 85.5 2F3M0@1|root,33WE8@2|Bacteria,1ZTTF@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - k59_314023_1 153948.NAL212_1483 1.2e-94 293.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2VI1K@28216|Betaproteobacteria,371PP@32003|Nitrosomonadales 28216|Betaproteobacteria FP Ppx GppA phosphatase ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_993107_2 626887.J057_19010 1.3e-27 109.0 COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,1S3RM@1236|Gammaproteobacteria,467G5@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - - - - - - - - - - - Glycos_transf_2 k59_53005_1 1232683.ADIMK_0271 6.23e-24 103.0 COG0412@1|root,COG0412@2|Bacteria,1MW88@1224|Proteobacteria,1RQD9@1236|Gammaproteobacteria,46DID@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Dienelactone hydrolase family - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH,SnoaL_2 k59_627612_1 138119.DSY4826 8.83e-45 165.0 COG0661@1|root,COG0661@2|Bacteria,1TPIV@1239|Firmicutes,24BTR@186801|Clostridia,264V1@186807|Peptococcaceae 186801|Clostridia S ABC1 family - - - - - - - - - - - - ABC1 k59_157179_2 933262.AXAM01000066_gene1685 1.66e-21 91.7 COG3117@1|root,COG3117@2|Bacteria,1QWNI@1224|Proteobacteria,42WSC@68525|delta/epsilon subdivisions,2X74E@28221|Deltaproteobacteria,2MPJV@213118|Desulfobacterales 28221|Deltaproteobacteria S Lipopolysaccharide-assembly, LptC-related - - - ko:K11719 - - - - ko00000,ko02000 1.B.42.1 - - LptC k59_1306424_2 247490.KSU1_C1671 2.03e-12 73.6 COG1538@1|root,COG1538@2|Bacteria,2IZPU@203682|Planctomycetes 203682|Planctomycetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_261814_1 1469245.JFBG01000013_gene1926 6.87e-09 55.5 COG2221@1|root,COG2221@2|Bacteria,1MVZQ@1224|Proteobacteria,1RQXZ@1236|Gammaproteobacteria,1WWM7@135613|Chromatiales 135613|Chromatiales C reductase, dissimilatory-type beta subunit dsrB - 1.8.99.5 ko:K11181 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_261814_2 1255043.TVNIR_0858 2.2e-75 226.0 COG1553@1|root,COG1553@2|Bacteria,1N021@1224|Proteobacteria,1S99J@1236|Gammaproteobacteria,1WY2D@135613|Chromatiales 135613|Chromatiales P TIGRFAM sulfur relay protein TusD DsrE dsrE GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0019417,GO:0044237,GO:0055114 - ko:K07235 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DrsE k59_1254340_2 1192034.CAP_7056 8.21e-61 192.0 COG0824@1|root,COG0824@2|Bacteria,1RGZN@1224|Proteobacteria,430GE@68525|delta/epsilon subdivisions,2WVY9@28221|Deltaproteobacteria,2YV8D@29|Myxococcales 28221|Deltaproteobacteria S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_157183_1 439235.Dalk_1183 9.62e-54 191.0 COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria,2MITA@213118|Desulfobacterales 28221|Deltaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom k59_1410913_1 391615.ABSJ01000045_gene2042 9.73e-30 112.0 COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,1J4TB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrD GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015672,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030001,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0051179,GO:0051234,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.6.5.8 ko:K00349 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_1410913_2 1201290.M902_2819 1.03e-24 100.0 COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,42RMS@68525|delta/epsilon subdivisions,2WNG3@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrC - 1.6.5.8 ko:K00348 - - - - ko00000,ko01000 - - - FMN_bind k59_1202206_1 330214.NIDE3136 2.49e-77 253.0 COG0845@1|root,COG1994@1|root,COG0845@2|Bacteria,COG1994@2|Bacteria 2|Bacteria S metallopeptidase activity - - - ko:K01993,ko:K13408,ko:K16922 ko04626,map04626 M00339 - - ko00000,ko00001,ko00002,ko01002,ko02000,ko02044 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_314039_1 68170.KL590510_gene7215 7.43e-94 279.0 COG3647@1|root,COG3647@2|Bacteria,2IATE@201174|Actinobacteria,4E3YF@85010|Pseudonocardiales 201174|Actinobacteria S Predicted membrane protein (DUF2238) - - - ko:K08984 - - - - ko00000 - - - DUF2238 k59_1202207_1 1395516.PMO01_01740 1.27e-09 63.9 COG3307@1|root,COG3307@2|Bacteria,1NGAP@1224|Proteobacteria,1SE8K@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Polymerase - - - - - - - - - - - - Wzy_C k59_1463226_1 1382359.JIAL01000001_gene1962 3.46e-32 119.0 COG0669@1|root,COG0669@2|Bacteria,3Y4B6@57723|Acidobacteria,2JJ6A@204432|Acidobacteriia 204432|Acidobacteriia H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_1149818_1 1442599.JAAN01000030_gene2146 1.2e-57 198.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1X4Q2@135614|Xanthomonadales 135614|Xanthomonadales S transporter oliA - - - - - - - - - - - OPT k59_53027_1 448385.sce6525 9.34e-17 86.3 COG1662@1|root,COG1662@2|Bacteria,1MV8R@1224|Proteobacteria 1224|Proteobacteria L PFAM IS1 transposase - - - - - - - - - - - - - k59_627638_1 1072685.IX83_01080 7.81e-07 53.1 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2VIKF@28216|Betaproteobacteria,3T1WT@506|Alcaligenaceae 28216|Betaproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_627638_2 857087.Metme_0162 2.4e-67 227.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XEFJ@135618|Methylococcales 135618|Methylococcales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_993124_1 316057.RPD_1532 1.08e-17 83.6 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,3JUZI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg MA20_01045 - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N,Transketolase_C k59_993124_2 748247.AZKH_2908 6.34e-45 153.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2VIQM@28216|Betaproteobacteria,2KY5Y@206389|Rhodocyclales 206389|Rhodocyclales C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_366381_1 316274.Haur_2432 1.47e-88 270.0 COG0667@1|root,COG0667@2|Bacteria,2G681@200795|Chloroflexi 200795|Chloroflexi C Aldo/keto reductase family - - - ko:K19265 - - - - ko00000,ko01000 - - - Aldo_ket_red k59_1097562_1 1121403.AUCV01000003_gene1688 1.18e-36 124.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WR92@28221|Deltaproteobacteria,2MKYU@213118|Desulfobacterales 28221|Deltaproteobacteria K PFAM Cold-shock - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_679903_1 292415.Tbd_2399 1.48e-30 114.0 COG0607@1|root,COG0607@2|Bacteria,1MZ83@1224|Proteobacteria,2VU3D@28216|Betaproteobacteria,1KRUK@119069|Hydrogenophilales 119069|Hydrogenophilales P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_679903_2 159087.Daro_0613 4.16e-11 62.0 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2VQ1Q@28216|Betaproteobacteria,2KW5X@206389|Rhodocyclales 206389|Rhodocyclales U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB - - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_314053_1 545264.KB898745_gene1256 5.28e-57 185.0 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,1WXEP@135613|Chromatiales 135613|Chromatiales E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_157195_1 1121013.P873_00795 2.6e-14 67.8 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_157195_2 945543.VIBR0546_00330 4.53e-21 92.4 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RMKD@1236|Gammaproteobacteria,1XSE7@135623|Vibrionales 135623|Vibrionales P ammonium transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_784340_1 1242864.D187_001705 7.32e-61 198.0 29YSD@1|root,30KNG@2|Bacteria,1PRVE@1224|Proteobacteria,4351K@68525|delta/epsilon subdivisions,2X519@28221|Deltaproteobacteria,2YZZ2@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - Zn_Tnp_IS91 k59_575300_1 713586.KB900536_gene1412 1.93e-54 182.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1WXKK@135613|Chromatiales 135613|Chromatiales P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_1097565_1 264730.PSPPH_4137 2.48e-65 213.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1Z6YQ@136849|Pseudomonas syringae group 1236|Gammaproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_679905_1 94624.Bpet1893 1.16e-34 132.0 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,2VH49@28216|Betaproteobacteria,3T2X3@506|Alcaligenaceae 28216|Betaproteobacteria G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB - - ko:K19804 - - - - ko00000 - - - TPR_16,TPR_7 k59_731936_1 323848.Nmul_A0924 2.47e-102 320.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,371QF@32003|Nitrosomonadales 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane - - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SecA_DEAD,SecA_PP_bind k59_1567695_1 330214.NIDE1343 2.5e-106 312.0 COG1137@1|root,COG1137@2|Bacteria,3J0GJ@40117|Nitrospirae 40117|Nitrospirae S ABC transporter - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_105099_1 398511.BpOF4_12365 1.08e-33 130.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,4H9WH@91061|Bacilli,1ZCD8@1386|Bacillus 91061|Bacilli P Rhodanese Homology Domain - - - - - - - - - - - - Lactamase_B,Rhodanese k59_1202238_1 1469607.KK073768_gene3917 1.74e-35 127.0 COG3415@1|root,COG3415@2|Bacteria,1G802@1117|Cyanobacteria 1117|Cyanobacteria L Homeodomain-like domain - - - - - - - - - - - - HTH_23,HTH_32 k59_1202238_2 485916.Dtox_0147 1.55e-08 56.2 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1UQRR@1239|Firmicutes,24BSD@186801|Clostridia,2645U@186807|Peptococcaceae 186801|Clostridia L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 k59_940928_1 290397.Adeh_1919 5.53e-69 219.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2WJ5K@28221|Deltaproteobacteria,2YXN1@29|Myxococcales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_105106_1 926566.Terro_1720 9.53e-70 226.0 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,3Y3GZ@57723|Acidobacteria,2JIAU@204432|Acidobacteriia 204432|Acidobacteriia M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase - - - - - - - - - - - - Bac_transf,CoA_binding_3 k59_731948_1 324057.Pjdr2_5636 1.02e-67 233.0 COG2352@1|root,COG2352@2|Bacteria,1TQB6@1239|Firmicutes,4HCAF@91061|Bacilli,26QIW@186822|Paenibacillaceae 91061|Bacilli C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_1515291_1 1117647.M5M_05010 3.14e-66 216.0 COG3203@1|root,COG3203@2|Bacteria,1R5I5@1224|Proteobacteria,1RM86@1236|Gammaproteobacteria,1J7SJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M phosphate-selective porin O and P - - - - - - - - - - - - Porin_4,Porin_O_P k59_1202251_1 246197.MXAN_7443 3.83e-66 215.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,2YWVA@29|Myxococcales 28221|Deltaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_627679_1 187272.Mlg_1601 6.5e-19 88.2 COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1X042@135613|Chromatiales 135613|Chromatiales Q Phosphate acyltransferases - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C,Acyltransferase,PP-binding k59_522971_1 710685.MycrhN_0099 2.46e-124 367.0 COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,238E1@1762|Mycobacteriaceae 201174|Actinobacteria C carnitine dehydratase - - - - - - - - - - - - CoA_transf_3 k59_1254397_2 330214.NIDE0423 5.31e-121 358.0 COG0128@1|root,COG0128@2|Bacteria,3J0BZ@40117|Nitrospirae 40117|Nitrospirae E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_53074_1 1173020.Cha6605_5097 1.12e-51 182.0 COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1G217@1117|Cyanobacteria 1117|Cyanobacteria CE Belongs to the aldehyde dehydrogenase family putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh k59_53082_1 1415778.JQMM01000001_gene174 1.18e-55 191.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria,1J4HE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Na+/Pi-cotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans k59_790795_1 1167006.UWK_01599 1.22e-25 107.0 COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,42P0U@68525|delta/epsilon subdivisions,2WJC6@28221|Deltaproteobacteria,2MIDV@213118|Desulfobacterales 28221|Deltaproteobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_1518857_1 671143.DAMO_0884 3.43e-50 175.0 COG2887@1|root,COG2887@2|Bacteria,2NQTZ@2323|unclassified Bacteria 2|Bacteria L PD-(D/E)XK nuclease superfamily - - 3.6.4.12 ko:K03657,ko:K07465 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1 k59_1625132_1 1219045.BV98_003252 4.29e-05 47.8 COG4774@1|root,COG4774@2|Bacteria,1QPVC@1224|Proteobacteria,2U4WC@28211|Alphaproteobacteria,2K32N@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1311630_1 118173.KB235914_gene3539 8.98e-27 101.0 COG2963@1|root,COG2963@2|Bacteria,1GA7D@1117|Cyanobacteria,1HGED@1150|Oscillatoriales 1117|Cyanobacteria L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_1311630_2 91604.ID47_07430 1.59e-17 80.9 COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2TRX0@28211|Alphaproteobacteria,47G6C@766|Rickettsiales 766|Rickettsiales L HTH-like domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_1261027_2 314230.DSM3645_01941 0.000218 44.7 COG0488@1|root,COG0488@2|Bacteria,2IX59@203682|Planctomycetes 203682|Planctomycetes S ABC transporter - - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_1572620_1 1229909.NSED_07055 5.15e-88 266.0 COG0111@1|root,arCOG01754@2157|Archaea,41S8U@651137|Thaumarchaeota 651137|Thaumarchaeota H D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_475906_1 215803.DB30_7457 6.89e-08 56.2 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YU4Y@29|Myxococcales 28221|Deltaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_475906_2 1144275.COCOR_04005 2.4e-19 89.7 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YU@28221|Deltaproteobacteria,2YY04@29|Myxococcales 28221|Deltaproteobacteria KT GAF domain - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,PAS_9,Sigma54_activat k59_1155063_1 1385935.N836_02205 6.7e-06 47.8 COG1087@1|root,COG1087@2|Bacteria,1G08G@1117|Cyanobacteria,1H70H@1150|Oscillatoriales 1117|Cyanobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_1155063_2 1118054.CAGW01000014_gene225 5.52e-29 111.0 COG0350@1|root,COG0350@2|Bacteria,1VA03@1239|Firmicutes,4HETA@91061|Bacilli,26XF4@186822|Paenibacillaceae 91061|Bacilli L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated adaB - 2.1.1.63 ko:K00567,ko:K10778,ko:K13531 - - - - ko00000,ko01000,ko03000,ko03400 - - - DNA_binding_1,Methyltransf_1N k59_371508_1 1229909.NSED_08810 4.18e-84 256.0 COG1422@1|root,arCOG02673@2157|Archaea,41SNR@651137|Thaumarchaeota 651137|Thaumarchaeota U membrane - - - - - - - - - - - - DUF106 k59_945717_1 498211.CJA_3399 1.07e-31 123.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1FFRG@10|Cellvibrio 1236|Gammaproteobacteria T Bacterial regulatory protein, Fis family prsR - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_737131_1 323261.Noc_2509 2e-126 377.0 COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,1RNFJ@1236|Gammaproteobacteria,1WWXB@135613|Chromatiales 135613|Chromatiales T PFAM PrkA AAA - - - ko:K07180 - - - - ko00000 - - - AAA_PrkA,PrkA k59_319790_1 395493.BegalDRAFT_0987 8.15e-236 673.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,45ZUC@72273|Thiotrichales 72273|Thiotrichales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_267168_1 420324.KI911971_gene2990 2.1e-21 95.5 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,1JY2I@119045|Methylobacteriaceae 28211|Alphaproteobacteria Q Phytoene dehydrogenase MA20_01895 - - - - - - - - - - - Amino_oxidase k59_1208957_2 700598.Niako_2267 0.000489 45.8 2DSNU@1|root,33GV1@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4136) - - - - - - - - - - - - DUF4136 k59_634266_1 469383.Cwoe_4091 1.17e-40 148.0 COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria,4CTCX@84995|Rubrobacteria 84995|Rubrobacteria C Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_1102973_1 1158756.AQXQ01000009_gene1057 7.04e-70 219.0 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,1S3MU@1236|Gammaproteobacteria,1X29U@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_1102973_2 400682.PAC_15706242 2.53e-24 96.7 COG2331@1|root,2SYQZ@2759|Eukaryota 2759|Eukaryota S Putative regulatory protein - - - - - - - - - - - - Zn-ribbon_8 k59_1102973_3 765911.Thivi_3139 4.71e-28 105.0 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,1SCTJ@1236|Gammaproteobacteria,1WYK5@135613|Chromatiales 135613|Chromatiales S PFAM Sulphur oxidation protein SoxZ - - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ k59_1102973_4 1123518.ARWI01000001_gene266 5.13e-06 47.4 COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,1S4ZT@1236|Gammaproteobacteria,461A3@72273|Thiotrichales 72273|Thiotrichales S Sulfur oxidation protein SoxY - - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY,TAT_signal k59_1572627_1 388051.AUFE01000057_gene4928 7.12e-25 108.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VHW3@28216|Betaproteobacteria,1K0M0@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family bepF - - ko:K18901 - M00698 - - ko00000,ko00002,ko01504,ko02000 2.A.6.2,8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1572627_2 335543.Sfum_1457 9.02e-31 120.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MR4N@213462|Syntrophobacterales 28221|Deltaproteobacteria V Protein export membrane protein bepE - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_214730_1 857087.Metme_4126 1.73e-92 279.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,1XDMX@135618|Methylococcales 135618|Methylococcales H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group cyoE - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_528049_1 1121374.KB891588_gene3420 4.54e-47 161.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_1469179_1 331869.BAL199_21289 2.26e-35 134.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2UE45@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Tpr repeat-containing protein - - - - - - - - - - - - 2OG-FeII_Oxy_5,TPR_16,TPR_19 k59_1469179_2 167555.NATL1_00431 8.32e-14 76.3 COG0457@1|root,COG4122@1|root,COG0457@2|Bacteria,COG4122@2|Bacteria 2|Bacteria E O-methyltransferase activity - - - - - - - - - - - - Methyltransf_24,TPR_8 k59_267173_1 1123073.KB899242_gene919 5.69e-13 69.7 COG3305@1|root,COG3305@2|Bacteria,1NA3D@1224|Proteobacteria,1T0NI@1236|Gammaproteobacteria,1XD0Z@135614|Xanthomonadales 135614|Xanthomonadales S Predicted membrane protein (DUF2127) - - - - - - - - - - - - DUF2127 k59_1416265_1 330214.NIDE2643 1.14e-48 168.0 COG0795@1|root,COG0795@2|Bacteria,3J0QQ@40117|Nitrospirae 40117|Nitrospirae S Predicted permease YjgP/YjgQ family - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1102982_1 321327.CYA_2536 6.39e-09 54.3 COG1371@1|root,COG1371@2|Bacteria,1G7JS@1117|Cyanobacteria 1117|Cyanobacteria S Archease protein family (MTH1598/TM1083) - - - - - - - - - - - - Archease k59_1102982_2 338969.Rfer_3852 2.51e-69 223.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,2VJ89@28216|Betaproteobacteria,4AFB1@80864|Comamonadaceae 28216|Betaproteobacteria S tRNA-splicing ligase RtcB rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_686356_2 1089552.KI911559_gene1441 5.93e-08 57.0 COG2214@1|root,COG2214@2|Bacteria,1PUS9@1224|Proteobacteria,2TT35@28211|Alphaproteobacteria,2JS9H@204441|Rhodospirillales 204441|Rhodospirillales O DnaJ molecular chaperone homology domain - - - - - - - - - - - - DnaJ k59_634292_1 1123368.AUIS01000004_gene157 5.48e-60 206.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,2NE5V@225057|Acidithiobacillales 1236|Gammaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035,ko:K13889 ko02010,ko02024,map02010,map02024 M00239,M00348 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.11 - - SBP_bac_5 k59_475936_1 981085.XP_010089666.1 8.97e-15 77.8 COG0304@1|root,KOG1394@2759|Eukaryota,37IDA@33090|Viridiplantae,3G7A1@35493|Streptophyta,4JJ41@91835|fabids 35493|Streptophyta IQ 3-oxoacyl- acyl-carrier-protein synthase II - GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006636,GO:0006950,GO:0007275,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009266,GO:0009409,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009628,GO:0009631,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0033559,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0050896,GO:0061458,GO:0071704,GO:0072330,GO:1901576 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_475936_2 439235.Dalk_1749 1.21e-19 82.4 COG0236@1|root,COG0236@2|Bacteria,1NII3@1224|Proteobacteria,433M2@68525|delta/epsilon subdivisions,2WXKX@28221|Deltaproteobacteria 28221|Deltaproteobacteria IQ Phosphopantetheine attachment site - - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_1311676_1 412965.COSY_0784 5.19e-66 214.0 COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,1SMKH@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_475937_1 1229780.BN381_430045 1.75e-46 167.0 COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria 201174|Actinobacteria IQ synthetase fadD19_2 - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_841727_1 330214.NIDE0563 4.33e-75 241.0 COG1032@1|root,COG1032@2|Bacteria,3J0WM@40117|Nitrospirae 40117|Nitrospirae C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_1416288_1 436308.Nmar_1061 5.39e-10 59.3 arCOG01995@1|root,arCOG01995@2157|Archaea,41T3M@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - SpoIIM k59_1416288_2 436308.Nmar_0002 1.17e-29 116.0 COG1311@1|root,arCOG04455@2157|Archaea,41T0D@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polB - 2.7.7.7 ko:K02323 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - DNA_pol_E_B k59_214766_1 236097.ADG881_699 4.86e-27 114.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,1RQXJ@1236|Gammaproteobacteria,1XIWP@135619|Oceanospirillales 135619|Oceanospirillales P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3708 k59_686391_1 1229909.NSED_06360 2.51e-69 212.0 COG0251@1|root,arCOG01630@2157|Archaea,41T4N@651137|Thaumarchaeota 651137|Thaumarchaeota J YjgF/chorismate_mutase-like, putative endoribonuclease - - - - - - - - - - - - YjgF_endoribonc k59_737180_1 1038858.AXBA01000022_gene3564 2.08e-20 92.4 COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,2VF7K@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG2199 FOG GGDEF domain - - - - - - - - - - - - GGDEF k59_580522_1 1082933.MEA186_07489 1.39e-25 111.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - TPR_11,TPR_16,TPR_8,Trans_reg_C k59_1518902_1 1177154.Y5S_01111 8.56e-06 45.4 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,1S8WZ@1236|Gammaproteobacteria,1XKHQ@135619|Oceanospirillales 135619|Oceanospirillales J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_1518902_2 344747.PM8797T_15421 2e-39 148.0 COG0334@1|root,COG0334@2|Bacteria,2IWWC@203682|Planctomycetes 203682|Planctomycetes C Belongs to the Glu Leu Phe Val dehydrogenases family - - - - - - - - - - - - ELFV_dehydrog,ELFV_dehydrog_N k59_1050798_1 2754.EH55_01285 3.48e-09 60.8 2AGTB@1|root,3171D@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF2833 k59_267213_1 161156.JQKW01000006_gene1247 2.17e-96 296.0 COG3635@1|root,COG3635@2|Bacteria,2GGY7@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria G 2,3-bisphosphoglycerate-independent phosphoglycerate mutase apgM - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase k59_1050801_1 322710.Avin_11780 1.43e-27 112.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria 1236|Gammaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_0027,iPC815.YPO0475 Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_1050801_2 207954.MED92_18263 2.87e-36 128.0 COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,1S60E@1236|Gammaproteobacteria,1XK4C@135619|Oceanospirillales 135619|Oceanospirillales MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_841743_1 396588.Tgr7_3316 2.84e-129 385.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1WXBH@135613|Chromatiales 135613|Chromatiales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_371561_1 236097.ADG881_1369 1.85e-31 121.0 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria,1XKC3@135619|Oceanospirillales 135619|Oceanospirillales D COG1192 ATPases involved in chromosome partitioning - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_371561_2 1437425.CSEC_2420 1.78e-49 162.0 COG3411@1|root,COG3411@2|Bacteria,2JH6P@204428|Chlamydiae 204428|Chlamydiae C Ferredoxin - - - - - - - - - - - - - k59_790894_1 713586.KB900536_gene448 1.19e-79 251.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1WVW6@135613|Chromatiales 135613|Chromatiales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_1155120_1 1205680.CAKO01000002_gene3015 7.82e-93 280.0 COG1028@1|root,COG1028@2|Bacteria,1R3U8@1224|Proteobacteria,2U1SI@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ KR domain - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1155120_2 243231.GSU0486 5.28e-58 199.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,42MKY@68525|delta/epsilon subdivisions,2WM9K@28221|Deltaproteobacteria,43S98@69541|Desulfuromonadales 28221|Deltaproteobacteria E PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit tdcB - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1469250_1 1123368.AUIS01000017_gene2611 1.09e-144 422.0 COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,1RPN7@1236|Gammaproteobacteria 1236|Gammaproteobacteria E peptidase, M20 - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_214796_1 1123368.AUIS01000010_gene2395 1.85e-46 167.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RZ20@1236|Gammaproteobacteria,2NE5G@225057|Acidithiobacillales 1236|Gammaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - EAL,GGDEF k59_1469258_1 1122611.KB903963_gene4760 1.47e-09 63.9 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - P_proprotein,Peptidase_S8,VCBS k59_1311716_1 305900.GV64_19805 3.09e-13 78.6 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1XH98@135619|Oceanospirillales 135619|Oceanospirillales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_998170_1 589865.DaAHT2_2063 1.17e-54 179.0 COG0524@1|root,COG0524@2|Bacteria,1QMIR@1224|Proteobacteria,42NDK@68525|delta/epsilon subdivisions,2WK15@28221|Deltaproteobacteria 28221|Deltaproteobacteria G PFAM PfkB domain protein - - 2.7.1.20 ko:K00856 ko00230,ko01100,map00230,map01100 - R00185 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_475984_1 713587.THITH_13295 5.01e-35 134.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WWGD@135613|Chromatiales 135613|Chromatiales T response regulator - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_475984_2 314275.MADE_1018180 7.49e-24 101.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RSDZ@1236|Gammaproteobacteria,4674K@72275|Alteromonadaceae 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1155137_2 635013.TherJR_0997 1.72e-88 293.0 COG0395@1|root,COG5001@1|root,COG5002@1|root,COG0395@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,26021@186807|Peptococcaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_8,PAS_9 k59_160800_1 1158756.AQXQ01000003_gene115 2.56e-10 65.5 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RMDA@1236|Gammaproteobacteria,1X0TW@135613|Chromatiales 135613|Chromatiales MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_946197_2 1279038.KB907340_gene1730 1.24e-169 478.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria,2JPJ9@204441|Rhodospirillales 204441|Rhodospirillales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_687051_1 713586.KB900536_gene585 8.72e-160 461.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1WWJ0@135613|Chromatiales 135613|Chromatiales F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_1364612_1 443144.GM21_2369 4.05e-60 212.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PGC@68525|delta/epsilon subdivisions,2WKHK@28221|Deltaproteobacteria,43UFI@69541|Desulfuromonadales 28221|Deltaproteobacteria T Domains Cache_1, HAMP, PAS, PAS - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,dCache_1 k59_1312199_1 1266914.ATUK01000014_gene2187 2.89e-46 159.0 COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,1WXHM@135613|Chromatiales 135613|Chromatiales IQ PFAM Short-chain dehydrogenase reductase SDR - - 1.5.1.33 ko:K03793 - - - - ko00000,ko01000 - - - adh_short_C2 k59_737676_1 243233.MCA0467 4.98e-11 63.9 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1XE9D@135618|Methylococcales 135618|Methylococcales S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_737676_2 765914.ThisiDRAFT_1245 3.55e-12 68.6 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,1RPH9@1236|Gammaproteobacteria,1WXJ3@135613|Chromatiales 135613|Chromatiales E PFAM Transglutaminase-like - - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_1209676_1 1046724.KB889827_gene2643 3.75e-62 203.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,46522@72275|Alteromonadaceae 1236|Gammaproteobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_1521679_1 66373.JOFQ01000003_gene5729 6.88e-38 140.0 COG0463@1|root,COG0463@2|Bacteria,2I3C0@201174|Actinobacteria 201174|Actinobacteria M PFAM Glycosyl transferase family 2 - - - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 k59_1315579_1 349521.HCH_01889 2.12e-45 154.0 COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,1RPAD@1236|Gammaproteobacteria,1XJEJ@135619|Oceanospirillales 135619|Oceanospirillales C Part of a membrane complex involved in electron transport rnfG - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_1315579_2 323261.Noc_1170 3.98e-13 67.8 COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,1RMEH@1236|Gammaproteobacteria,1WWBK@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_1576724_1 314285.KT71_01405 2.69e-52 171.0 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,1J4T6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H riboflavin synthase, alpha ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_1576724_2 2340.JV46_06540 3.92e-41 148.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1J4HI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008703,GO:0008835,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.1.1.193,3.5.4.26 ko:K01498,ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_00366,iECBD_1354.ECBD_3247,iECB_1328.ECB_00362,iECD_1391.ECD_00362,iECED1_1282.ECED1_0437,iECNA114_1301.ECNA114_0391,iECSF_1327.ECSF_0374,iEcolC_1368.EcolC_3219,iLF82_1304.LF82_1880,iNRG857_1313.NRG857_01945,iYL1228.KPN_00366,ic_1306.c0524 RibD_C,dCMP_cyt_deam_1 k59_1368309_2 983545.Glaag_1040 1.44e-13 72.0 COG1595@1|root,COG1595@2|Bacteria,1MVPD@1224|Proteobacteria,1S5DM@1236|Gammaproteobacteria,468JA@72275|Alteromonadaceae 1236|Gammaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_1107363_1 936136.ARRT01000006_gene1421 7.29e-34 136.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc,TPR_16,TPR_8 k59_1002093_1 330214.NIDE0983 3.46e-77 236.0 COG0118@1|root,COG0118@2|Bacteria,3J0K7@40117|Nitrospirae 40117|Nitrospirae E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_480856_1 713586.KB900536_gene2575 2.91e-61 198.0 COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,1RQ6Z@1236|Gammaproteobacteria,1WWM0@135613|Chromatiales 135613|Chromatiales P extracellular solute-binding protein - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 k59_949860_1 1047013.AQSP01000133_gene2111 1.6e-50 182.0 COG0178@1|root,COG0178@2|Bacteria,2NQR8@2323|unclassified Bacteria 2|Bacteria L ABC transporter uvrA2 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1315601_2 883078.HMPREF9695_00085 4.59e-26 105.0 COG0300@1|root,COG0300@2|Bacteria,1MWNZ@1224|Proteobacteria,2TTFS@28211|Alphaproteobacteria,3JSV1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S KR domain - - - ko:K07124 - - - - ko00000 - - - adh_short k59_741287_1 323261.Noc_2775 6.15e-92 283.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RSN1@1236|Gammaproteobacteria,1WVUQ@135613|Chromatiales 135613|Chromatiales I PFAM Fatty acid desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - DDE_Tnp_ISL3,FA_desaturase k59_428128_1 1356854.N007_16675 3.92e-10 64.3 COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,4HDG6@91061|Bacilli 91061|Bacilli L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_4,Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase k59_428128_2 478741.JAFS01000002_gene783 1.41e-21 87.4 COG4679@1|root,COG4679@2|Bacteria 2|Bacteria K PFAM Phage derived protein Gp49-like (DUF891) - - - - - - - - - - - - Gp49 k59_324284_1 2340.JV46_28050 3.35e-18 80.9 COG0790@1|root,COG0790@2|Bacteria,1PDUX@1224|Proteobacteria,1RW86@1236|Gammaproteobacteria,1JBN1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sel1-like repeats. - - - - - - - - - - - - Sel1 k59_65295_1 391937.NA2_21118 8e-21 90.9 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,43MYQ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L HTH-like domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_1107395_1 765913.ThidrDRAFT_1561 1.53e-19 90.9 COG1196@1|root,COG2885@1|root,COG1196@2|Bacteria,COG2885@2|Bacteria,1REH1@1224|Proteobacteria,1S139@1236|Gammaproteobacteria,1WXRM@135613|Chromatiales 135613|Chromatiales M Belongs to the ompA family - - - - - - - - - - - - OmpA k59_324293_2 113395.AXAI01000014_gene169 1.82e-13 77.4 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,3JWX8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E TOBE domain - - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 k59_1474622_1 1042377.AFPJ01000030_gene436 2.6e-52 184.0 COG1629@1|root,COG4771@2|Bacteria,1MUNK@1224|Proteobacteria,1RN9S@1236|Gammaproteobacteria,464ZY@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_584655_1 1121381.JNIV01000005_gene2609 4.16e-21 100.0 COG2267@1|root,COG2267@2|Bacteria,1WIH1@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4 k59_1055081_1 1049564.TevJSym_ap00750 1.62e-52 177.0 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,1J6GX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Thioredoxin ybbN GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0061077 - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_65316_1 1254432.SCE1572_14535 2.77e-101 305.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,42M1J@68525|delta/epsilon subdivisions,2WIQR@28221|Deltaproteobacteria,2YTUE@29|Myxococcales 28221|Deltaproteobacteria D Rod shape-determining protein mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_949887_2 1121013.P873_09410 1.85e-91 285.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1X2ZD@135614|Xanthomonadales 135614|Xanthomonadales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_219195_1 696281.Desru_3814 9.12e-72 246.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,2647S@186807|Peptococcaceae 186801|Clostridia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_4,PAS_9 k59_1214146_1 68260.JOAY01000007_gene49 9.26e-07 52.0 COG0229@1|root,COG0229@2|Bacteria,2IHV0@201174|Actinobacteria 201174|Actinobacteria O peptide-methionine (R)-S-oxide reductase msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_1214146_2 929558.SMGD1_1743 1.69e-156 457.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2YMCS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_584672_1 1267535.KB906767_gene5081 1.27e-08 61.6 COG1524@1|root,COG1524@2|Bacteria,3Y3I0@57723|Acidobacteria 57723|Acidobacteria S PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_428166_1 338969.Rfer_3895 4.98e-28 115.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria 28216|Betaproteobacteria G alpha-glucan phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_1107413_2 187272.Mlg_2693 8.23e-50 164.0 COG5622@1|root,COG5622@2|Bacteria,1NPM6@1224|Proteobacteria 1224|Proteobacteria N Protein required for attachment to host cells - - - - - - - - - - - - Host_attach k59_1214150_1 744980.TRICHSKD4_0194 3.78e-07 50.4 2DN6U@1|root,32VVA@2|Bacteria,1N6AG@1224|Proteobacteria,2TZ4M@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Cysteine rich repeat - - - - - - - - - - - - Cys_rich_FGFR k59_1266600_1 329726.AM1_1876 8.51e-77 258.0 COG0737@1|root,COG2374@1|root,COG2931@1|root,COG3391@1|root,COG4222@1|root,COG0737@2|Bacteria,COG2374@2|Bacteria,COG2931@2|Bacteria,COG3391@2|Bacteria,COG4222@2|Bacteria,1G0YK@1117|Cyanobacteria 1117|Cyanobacteria K phosphatase - - - - - - - - - - - - 5_nucleotid_C,Exo_endo_phos,HemolysinCabind,Phytase-like k59_428169_1 1396141.BATP01000047_gene3976 1.04e-39 138.0 COG3340@1|root,COG3340@2|Bacteria,46V1G@74201|Verrucomicrobia,2IVQ6@203494|Verrucomicrobiae 203494|Verrucomicrobiae E Peptidase family S51 - - - - - - - - - - - - Peptidase_S51 k59_271575_1 1384054.N790_11995 2.89e-58 194.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1X3E5@135614|Xanthomonadales 135614|Xanthomonadales O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_271575_2 1198232.CYCME_0911 1.77e-16 72.8 COG3242@1|root,COG3242@2|Bacteria 2|Bacteria S Uncharacterized protein conserved in bacteria (DUF2065) yjeT - - ko:K09937 - - - - ko00000 - - - DUF2065 k59_584677_1 1144275.COCOR_07791 2.04e-21 100.0 COG1463@1|root,COG1463@2|Bacteria,1MY8D@1224|Proteobacteria,42TCA@68525|delta/epsilon subdivisions,2WP6I@28221|Deltaproteobacteria,2YVND@29|Myxococcales 28221|Deltaproteobacteria Q ABC-type transport system involved in resistance to organic solvents periplasmic component - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_1055106_2 132113.XP_003492791.1 2.64e-34 133.0 COG0085@1|root,COG0222@1|root,KOG0214@2759|Eukaryota,KOG1715@2759|Eukaryota,39VWS@33154|Opisthokonta,3BM6Z@33208|Metazoa,3DDNE@33213|Bilateria 33208|Metazoa K DNA-directed 5'-3' RNA polymerase activity - - - - - - - - - - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5,RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1055106_3 1000565.METUNv1_02254 2.92e-14 70.1 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2VQ7A@28216|Betaproteobacteria,2KW86@206389|Rhodocyclales 206389|Rhodocyclales J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_1214154_1 391624.OIHEL45_12355 4.04e-44 151.0 COG4976@1|root,COG4976@2|Bacteria,1MXUV@1224|Proteobacteria,2TUPS@28211|Alphaproteobacteria 28211|Alphaproteobacteria S methyltransferase type - - - - - - - - - - - - Methyltransf_23,Methyltransf_25 k59_1214154_3 631362.Thi970DRAFT_04284 9.34e-47 157.0 COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,1RNXI@1236|Gammaproteobacteria,1WWCR@135613|Chromatiales 135613|Chromatiales K response regulator receiver - - - ko:K07684 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_1475610_3 28042.GU90_17710 0.000247 44.7 COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,4E2W5@85010|Pseudonocardiales 201174|Actinobacteria J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM GO:0008150,GO:0040007 - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_950653_2 565045.NOR51B_2163 6.49e-42 154.0 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,1RNBI@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_585468_1 935948.KE386495_gene1381 1.93e-25 109.0 COG0068@1|root,COG0068@2|Bacteria,1TQM7@1239|Firmicutes,2494A@186801|Clostridia,42EWS@68295|Thermoanaerobacterales 186801|Clostridia O Belongs to the carbamoyltransferase HypF family hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_1108156_1 1449357.JQLK01000001_gene2026 4.8e-52 172.0 COG1573@1|root,COG1573@2|Bacteria,1WJ72@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L TIGRFAM Phage SPO1 DNA polymerase-related protein - GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1159526_1 886293.Sinac_4491 5.5e-47 165.0 COG0309@1|root,COG0309@2|Bacteria,2IX50@203682|Planctomycetes 203682|Planctomycetes O AIR synthase related protein, C-terminal domain - - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_1159526_2 1123072.AUDH01000001_gene2791 6.74e-08 57.0 COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,2TTEG@28211|Alphaproteobacteria,2JVCU@204441|Rhodospirillales 204441|Rhodospirillales I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_1577528_1 1469245.JFBG01000010_gene600 9.61e-145 424.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_1002990_1 700508.D174_16460 7.48e-30 117.0 28M2T@1|root,2ZAH6@2|Bacteria,2H696@201174|Actinobacteria,237M6@1762|Mycobacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1002990_2 222534.KB893717_gene1965 5.81e-08 55.1 COG0500@1|root,COG0500@2|Bacteria,2I3GX@201174|Actinobacteria 201174|Actinobacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_31 k59_165594_1 265072.Mfla_0353 0.000264 43.9 COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,2VIFI@28216|Betaproteobacteria,2KNAM@206350|Nitrosomonadales 206350|Nitrosomonadales S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 k59_950674_1 344747.PM8797T_27849 2.38e-41 154.0 COG0695@1|root,COG0695@2|Bacteria,2J2HD@203682|Planctomycetes 203682|Planctomycetes O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins - - - - - - - - - - - - - k59_585484_1 1229780.BN381_100201 5.57e-25 102.0 COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,3UWIT@52018|unclassified Actinobacteria (class) 201174|Actinobacteria G Inositol monophosphatase family - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_66298_2 644801.Psest_0531 6.91e-138 403.0 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1Z0Z0@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria T phosphate starvation-inducible protein PhoH ybeZ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06217 - - - - ko00000 - - - PhoH k59_66298_3 999141.GME_06884 1.15e-12 67.8 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1XHQS@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_742070_1 595460.RRSWK_02125 3.01e-55 199.0 COG1357@1|root,COG1511@1|root,COG2931@1|root,COG3291@1|root,COG1357@2|Bacteria,COG1511@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,2IZ0P@203682|Planctomycetes 203682|Planctomycetes Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HemolysinCabind,Laminin_G_3 k59_1577546_1 1123073.KB899241_gene2686 6.42e-34 135.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1X5R3@135614|Xanthomonadales 135614|Xanthomonadales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1577546_2 1049564.TevJSym_ag01000 1.77e-13 70.1 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Response regulator receiver ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat k59_585493_2 1156937.MFUM_200030 9.95e-09 55.1 2DFNJ@1|root,2ZSFW@2|Bacteria,46WS2@74201|Verrucomicrobia,37HAT@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia S PurA ssDNA and RNA-binding protein - - - - - - - - - - - - PurA k59_325092_1 1131269.AQVV01000003_gene769 4.42e-07 57.4 COG0457@1|root,COG3794@1|root,COG0457@2|Bacteria,COG3794@2|Bacteria 2|Bacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - CarboxypepD_reg,TPR_16,fn3_3 k59_1003017_1 1336245.JAGO01000011_gene512 3.3e-23 103.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1XH6K@135619|Oceanospirillales 135619|Oceanospirillales J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_66320_1 1123519.PSJM300_04105 1.15e-69 231.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,1Z0RF@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - iECO103_1326.ECO103_0087,iECO111_1330.ECO111_0088,iECW_1372.ECW_m0084,iEKO11_1354.EKO11_3829,iWFL_1372.ECW_m0084,ic_1306.c0103 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1422072_1 485913.Krac_5202 8.28e-42 150.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_5,DDE_Tnp_1_4 k59_846830_1 187272.Mlg_2683 5.77e-45 178.0 COG3284@1|root,COG5001@1|root,COG5002@1|root,COG3284@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WXCR@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS_4,PAS_9,dCache_3 k59_66338_1 1123278.KB893562_gene3227 1.04e-10 66.6 COG2244@1|root,COG2244@2|Bacteria,4NFKD@976|Bacteroidetes,47MS1@768503|Cytophagia 976|Bacteroidetes S Membrane protein involved in the export of O-antigen and teichoic acid wzxC - - ko:K03328,ko:K16695 - - - - ko00000,ko02000 2.A.66.2,2.A.66.2.7 - - Polysacc_synt_3,Polysacc_synt_C k59_1055980_1 373994.Riv7116_3033 2.27e-59 205.0 COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria 1117|Cyanobacteria V ABC-type transport system involved in lipoprotein release permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1422097_1 926569.ANT_18670 3.11e-07 57.4 COG3225@1|root,COG3225@2|Bacteria 2|Bacteria - - gldG - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC_transp_aux k59_533177_1 436308.Nmar_0666 1.38e-117 340.0 COG0560@1|root,arCOG01158@2157|Archaea,41SHX@651137|Thaumarchaeota 651137|Thaumarchaeota E phosphoserine phosphatase - - 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - HAD k59_1577577_1 391625.PPSIR1_09380 6.1e-74 247.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,2YUJ6@29|Myxococcales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1267670_1 1417296.U879_04020 4.75e-72 225.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria 1224|Proteobacteria V non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_538460_1 97096.XP_007789190.1 2.88e-36 132.0 COG0163@1|root,2TFCT@2759|Eukaryota,3AI3U@33154|Opisthokonta,3PB8E@4751|Fungi,3QQZH@4890|Ascomycota,215X5@147550|Sordariomycetes 4751|Fungi H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN PAD1 - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_538460_2 572546.Arcpr_1251 3.36e-30 118.0 COG0382@1|root,arCOG00477@2157|Archaea,2XW9S@28890|Euryarchaeota,24617@183980|Archaeoglobi 183980|Archaeoglobi H 4-hydroxybenzoate polyprenyltransferase - - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_697379_1 269798.CHU_1078 7.27e-26 105.0 COG1560@1|root,COG1560@2|Bacteria,4NGQU@976|Bacteroidetes,47MHM@768503|Cytophagia 976|Bacteroidetes M Lipid A biosynthesis acyltransferase waaM - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_697379_2 1217718.ALOU01000112_gene4315 7.59e-08 53.9 COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria,2WBWX@28216|Betaproteobacteria,1K6U7@119060|Burkholderiaceae 28216|Betaproteobacteria I LssY C-terminus - - - - - - - - - - - - LssY_C k59_1375144_2 404589.Anae109_0092 2.52e-38 137.0 COG1215@1|root,COG1215@2|Bacteria,1RJNP@1224|Proteobacteria,42ST7@68525|delta/epsilon subdivisions,2X7I3@28221|Deltaproteobacteria,2Z24R@29|Myxococcales 28221|Deltaproteobacteria M Glycosyl transferase - - - - - - - - - - - - Glycos_transf_2 k59_226117_1 1049564.TevJSym_as00410 2.04e-19 84.0 2C1YJ@1|root,32ZXK@2|Bacteria,1N98H@1224|Proteobacteria,1SD8N@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2782) - - - - - - - - - - - - DUF2782 k59_226117_2 105559.Nwat_0588 8.82e-113 330.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1RSPA@1236|Gammaproteobacteria,1WX5Y@135613|Chromatiales 135613|Chromatiales S PFAM conserved - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_384823_1 395493.BegalDRAFT_1677 5.15e-157 463.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,45ZV1@72273|Thiotrichales 72273|Thiotrichales O ATP-dependent Clp protease ATP-binding subunit ClpA - - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1320933_1 373994.Riv7116_2881 6.08e-17 73.6 COG1598@1|root,COG1598@2|Bacteria,1G97T@1117|Cyanobacteria,1HU2I@1161|Nostocales 1117|Cyanobacteria S PFAM Uncharacterised protein family UPF0150 - - - - - - - - - - - - HicB_lk_antitox k59_853084_2 1144343.PMI41_01261 4.05e-63 204.0 COG1011@1|root,COG1011@2|Bacteria,1MU1H@1224|Proteobacteria,2TQVC@28211|Alphaproteobacteria,43K3P@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Haloacid dehalogenase-like hydrolase - - 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase k59_7908_1 717773.Thicy_0986 1.45e-52 181.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,45ZWD@72273|Thiotrichales 72273|Thiotrichales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_905529_1 1460640.JCM19046_3802 3.05e-15 76.3 COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,4HFNQ@91061|Bacilli,1ZAVP@1386|Bacillus 91061|Bacilli C glycerophosphoryl diester phosphodiesterase - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_905529_2 1122919.KB905640_gene401 1.98e-08 57.4 COG3291@1|root,COG3866@1|root,COG4677@1|root,COG4733@1|root,COG3291@2|Bacteria,COG3866@2|Bacteria,COG4677@2|Bacteria,COG4733@2|Bacteria,1TSCD@1239|Firmicutes,4HTSP@91061|Bacilli,26UST@186822|Paenibacillaceae 91061|Bacilli G Pectinesterase - - 3.1.1.11 ko:K01051 ko00040,ko01100,map00040,map01100 M00081 R02362 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Pec_lyase,Pectinesterase k59_435471_1 243233.MCA2414 3.46e-20 89.7 COG0438@1|root,COG0438@2|Bacteria,1REGP@1224|Proteobacteria,1S5DR@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4 k59_1483789_1 28229.ND2E_3370 8.88e-87 282.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q61E@267889|Colwelliaceae 1236|Gammaproteobacteria U Efflux pump membrane transporter - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_853093_1 247639.MGP2080_09988 2.23e-106 321.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,1T1GA@1236|Gammaproteobacteria,1J5D4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E O-acetylhomoserine sulfhydrylase metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_226137_1 342113.DM82_6287 1.06e-62 210.0 COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2VIXC@28216|Betaproteobacteria,1K5NA@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the peptidase S8 family mprA - - ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Peptidase_S8 k59_1430094_1 107636.JQNK01000009_gene3513 2.2e-129 382.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,370BU@31993|Methylocystaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_122600_1 1121374.KB891586_gene2692 5.92e-26 108.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RNWM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_122600_2 748658.KB907312_gene1156 4.04e-12 63.9 2CD0I@1|root,32RWS@2|Bacteria,1N0MC@1224|Proteobacteria,1SABW@1236|Gammaproteobacteria,1X19T@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4399) - - - - - - - - - - - - DUF4399 k59_806169_2 436308.Nmar_0969 2.65e-48 156.0 arCOG05276@1|root,arCOG05276@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - Pyr_excise k59_806169_3 1322246.BN4_10902 2.86e-11 62.8 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,42M4E@68525|delta/epsilon subdivisions,2WKFT@28221|Deltaproteobacteria,2M938@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_591720_1 1485545.JQLW01000009_gene119 3.93e-28 115.0 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria 1224|Proteobacteria H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_490263_1 883126.HMPREF9710_01337 2.71e-94 299.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,472RJ@75682|Oxalobacteraceae 28216|Betaproteobacteria C Malic enzyme, NAD binding domain maeB - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malate_DH,Malic_M,PTA_PTB,malic k59_1637482_2 795797.C497_15777 2.84e-42 150.0 COG1011@1|root,arCOG02291@2157|Archaea,2XTSX@28890|Euryarchaeota,23SXD@183963|Halobacteria 2157|Archaea S haloacid dehalogenase - - 3.8.1.2 ko:K01560,ko:K07025 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 k59_853117_1 1187851.A33M_4209 6.39e-29 122.0 COG1013@1|root,COG1013@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor - - - - - - - - - - - - Fer4,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1164593_2 466088.CL42_06090 6.7e-46 151.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,3NN4E@468|Moraxellaceae 1236|Gammaproteobacteria O Belongs to the MsrB Met sulfoxide reductase family msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_748281_1 436308.Nmar_0979 1.3e-69 219.0 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB k59_1276016_1 1185876.BN8_00730 6.37e-10 56.2 COG2151@1|root,COG2151@2|Bacteria,4NSA9@976|Bacteroidetes,47QBC@768503|Cytophagia 976|Bacteroidetes S FeS assembly SUF system protein yitW - - - - - - - - - - - FeS_assembly_P k59_1276016_2 1237149.C900_05659 6.43e-66 203.0 COG2166@1|root,COG2166@2|Bacteria,4NM9N@976|Bacteroidetes,47Q7A@768503|Cytophagia 976|Bacteroidetes S SufE protein probably involved in Fe-S center assembly sufE - - ko:K02426 - - - - ko00000 - - - SufE k59_1276017_1 1366046.HIMB11_02470 2.31e-43 159.0 COG1520@1|root,COG1520@2|Bacteria,1R4I1@1224|Proteobacteria,2U05B@28211|Alphaproteobacteria,3ZI1H@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - k59_806192_1 765911.Thivi_3315 5.73e-105 319.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1WVVC@135613|Chromatiales 135613|Chromatiales F TIGRFAM dihydroorotase, multifunctional complex type - - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_905587_1 765910.MARPU_01750 7.43e-76 233.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1WX3P@135613|Chromatiales 135613|Chromatiales E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG k59_1637499_2 1469245.JFBG01000027_gene1469 3.3e-103 306.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1WW7F@135613|Chromatiales 135613|Chromatiales EP PFAM Binding-protein-dependent transport - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_122640_1 1046724.KB889924_gene1399 7.52e-23 92.4 COG3703@1|root,COG3703@2|Bacteria,1PJ0F@1224|Proteobacteria,1RTSD@1236|Gammaproteobacteria,46C48@72275|Alteromonadaceae 1236|Gammaproteobacteria P Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides - - - - - - - - - - - - - k59_122640_2 1177928.TH2_19744 2.09e-32 125.0 COG0477@1|root,COG2814@2|Bacteria,1N2NP@1224|Proteobacteria,2TXTK@28211|Alphaproteobacteria,2JUI6@204441|Rhodospirillales 204441|Rhodospirillales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_698213_2 1269813.ATUL01000003_gene2478 1.53e-20 86.3 COG4577@1|root,COG4577@2|Bacteria,1QG1Y@1224|Proteobacteria,1RXZV@1236|Gammaproteobacteria,1WWCC@135613|Chromatiales 135613|Chromatiales CQ BMC - - - - - - - - - - - - BMC k59_806207_2 545264.KB898745_gene1177 2.1e-51 171.0 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1WX8U@135613|Chromatiales 135613|Chromatiales F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_171656_1 1380394.JADL01000001_gene2539 3.63e-115 349.0 COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria,1MU3V@1224|Proteobacteria,2TSGP@28211|Alphaproteobacteria,2JR05@204441|Rhodospirillales 204441|Rhodospirillales P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_226186_1 880073.Calab_1752 1.74e-92 283.0 COG1960@1|root,COG1960@2|Bacteria,2NQE6@2323|unclassified Bacteria 2|Bacteria I Acyl-CoA dehydrogenase, C-terminal domain gcdH GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1320974_2 298654.FraEuI1c_3320 3.3e-148 432.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1221585_1 765912.Thimo_2176 2.64e-37 139.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1WVWH@135613|Chromatiales 135613|Chromatiales G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_1221585_2 1249627.D779_1393 9.3e-43 148.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1WXC0@135613|Chromatiales 135613|Chromatiales G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_1276049_1 436308.Nmar_0034 5.15e-35 130.0 COG2512@1|root,arCOG00374@2157|Archaea,41SUX@651137|Thaumarchaeota 651137|Thaumarchaeota K membrane-associated protein domain - - - - - - - - - - - - - k59_1375221_1 1177928.TH2_14169 6.66e-86 264.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria,2JPP5@204441|Rhodospirillales 204441|Rhodospirillales Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_1375221_2 402881.Plav_2880 6.34e-38 139.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,1JNDU@119043|Rhodobiaceae 28211|Alphaproteobacteria Q Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_1276052_1 497964.CfE428DRAFT_1483 5.91e-75 237.0 COG0436@1|root,COG0436@2|Bacteria,46TMR@74201|Verrucomicrobia 74201|Verrucomicrobia E Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate - - 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_74482_1 1303518.CCALI_00166 1.24e-76 243.0 COG0247@1|root,COG0247@2|Bacteria 2|Bacteria C lactate metabolic process - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_17,Fer4_7,Fer4_8 k59_1009456_1 523841.HFX_1526 1.04e-23 105.0 COG4948@1|root,arCOG01168@2157|Archaea,2XU6X@28890|Euryarchaeota,23SAR@183963|Halobacteria 183963|Halobacteria H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) menC - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_1375224_1 1255043.TVNIR_0417 1.65e-83 251.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1WXF4@135613|Chromatiales 135613|Chromatiales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_1375224_2 472759.Nhal_3815 1.99e-95 292.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1WWDN@135613|Chromatiales 135613|Chromatiales S PFAM Peptidoglycan-binding lysin domain - - - - - - - - - - - - LysM k59_748317_1 1286106.MPL1_11683 8.49e-31 126.0 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,45ZVU@72273|Thiotrichales 72273|Thiotrichales M PFAM AsmA family - - - ko:K07289 - - - - ko00000 - - - AsmA k59_1526503_1 268746.Q58MZ2_BPPRM 9.85e-47 154.0 4QDXQ@10239|Viruses,4QV9C@35237|dsDNA viruses no RNA stage,4QQF2@28883|Caudovirales,4QIMB@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1526503_2 268746.Q58MZ3_BPPRM 2.75e-28 105.0 4QFVW@10239|Viruses,4QYZY@35237|dsDNA viruses no RNA stage,4QTSZ@28883|Caudovirales,4QIFQ@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_748318_1 1408423.JHYA01000006_gene511 1.23e-06 52.0 COG1538@1|root,COG1538@2|Bacteria,1VSFQ@1239|Firmicutes,4H7D5@909932|Negativicutes 909932|Negativicutes MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_748318_2 196490.AUEZ01000003_gene3858 1.33e-07 57.8 COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,2TTRG@28211|Alphaproteobacteria,3JTH8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M secretion protein - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_698242_1 330214.NIDE2086 1.22e-27 116.0 COG1074@1|root,COG1074@2|Bacteria,3J16M@40117|Nitrospirae 40117|Nitrospirae L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_1646860_1 156889.Mmc1_1581 3.12e-65 223.0 COG0243@1|root,COG1104@1|root,COG0243@2|Bacteria,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria 1224|Proteobacteria E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5,Molybdopterin,Molydop_binding k59_500229_1 1121413.JMKT01000010_gene963 8.29e-41 137.0 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,42TRE@68525|delta/epsilon subdivisions,2WQBH@28221|Deltaproteobacteria,2MBW5@213115|Desulfovibrionales 28221|Deltaproteobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_500229_2 397291.C804_03065 1.53e-17 79.3 COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,24833@186801|Clostridia,27IU4@186928|unclassified Lachnospiraceae 186801|Clostridia J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_1439907_1 1191523.MROS_0650 1.14e-72 234.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_444123_1 82996.sch_22565 1.56e-94 291.0 COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,1RQ8G@1236|Gammaproteobacteria 1236|Gammaproteobacteria E decarboxylase - - 4.1.1.86 ko:K13745 ko00260,ko01120,map00260,map01120 - R07650 RC00299 ko00000,ko00001,ko01000 - - - Pyridoxal_deC k59_1381971_1 1122919.KB905559_gene1363 2.69e-14 77.4 COG0371@1|root,COG0371@2|Bacteria,1TR6W@1239|Firmicutes,4HDXA@91061|Bacilli,26SMC@186822|Paenibacillaceae 91061|Bacilli C Dehydrogenase egsA - 1.1.1.261 ko:K00096 ko00564,map00564 - R05679,R05680 RC00029 ko00000,ko00001,ko01000 - - - Fe-ADH_2 k59_964114_1 1266908.AQPB01000054_gene1753 3.07e-13 67.4 COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,1S60E@1236|Gammaproteobacteria,1WY9G@135613|Chromatiales 135613|Chromatiales MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_964114_2 765911.Thivi_3223 1.67e-43 159.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1WXI8@135613|Chromatiales 135613|Chromatiales J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_1646883_2 864069.MicloDRAFT_00047220 1.81e-40 149.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2TQUJ@28211|Alphaproteobacteria,1JS6X@119045|Methylobacteriaceae 28211|Alphaproteobacteria G PFAM glycoside hydrolase family 13 domain protein treZ - 3.2.1.141 ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3459 k59_755646_1 1206725.BAFU01000238_gene5362 6.76e-85 265.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,4G4SY@85025|Nocardiaceae 201174|Actinobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 k59_1016899_1 713586.KB900536_gene1325 6.28e-59 210.0 COG0348@1|root,COG3901@1|root,COG0348@2|Bacteria,COG3901@2|Bacteria,1MY5M@1224|Proteobacteria,1RNSU@1236|Gammaproteobacteria 1236|Gammaproteobacteria CK Regulator of nitric oxide reductase transcription nosR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K19339 - - - - ko00000,ko03000 - - - FMN_bind,Fer4,Fer4_5 k59_1326628_2 867903.ThesuDRAFT_02283 2.84e-37 142.0 COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,3WCD6@538999|Clostridiales incertae sedis 186801|Clostridia L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_705454_1 330214.NIDE1213 5.63e-66 210.0 COG1398@1|root,COG1398@2|Bacteria 2|Bacteria I oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water desC - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_546278_1 330214.NIDE0260 6.68e-192 540.0 COG1219@1|root,COG1219@2|Bacteria,3J0AM@40117|Nitrospirae 40117|Nitrospirae O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_131436_1 426117.M446_5258 4.83e-28 113.0 COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,2TS12@28211|Alphaproteobacteria,1JR1J@119045|Methylobacteriaceae 28211|Alphaproteobacteria E PFAM Prephenate dehydrogenase tyrC GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43 ko:K00210,ko:K00220,ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025,M00040 R00732,R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_392107_1 706439.HMPREF9057_02868 4e-87 280.0 COG0370@1|root,COG0370@2|Bacteria,2GTV2@201174|Actinobacteria,4D44Z@85005|Actinomycetales 201174|Actinobacteria P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoA,FeoB_C,FeoB_N,Gate k59_338588_1 2340.JV46_03580 6.76e-73 238.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J8SM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Citrate transporter sac1 - - - - - - - - - - - CitMHS,TrkA_C k59_1326636_1 323261.Noc_1745 1.27e-67 215.0 COG0535@1|root,COG0535@2|Bacteria,1MXM1@1224|Proteobacteria,1RNQ1@1236|Gammaproteobacteria,1X06Z@135613|Chromatiales 135613|Chromatiales S Radical SAM domain - - - - - - - - - - - - DUF3463,Radical_SAM k59_1326636_2 472759.Nhal_1238 2.93e-12 67.4 COG1215@1|root,COG1215@2|Bacteria,1MW1E@1224|Proteobacteria,1RZY2@1236|Gammaproteobacteria,1X091@135613|Chromatiales 135613|Chromatiales M Glycosyl transferase family 21 - - - - - - - - - - - - Glyco_tranf_2_3 k59_659152_1 436114.SYO3AOP1_0958 3.17e-37 132.0 COG3271@1|root,COG3271@2|Bacteria,2G4YK@200783|Aquificae 200783|Aquificae S Papain-like cysteine protease AvrRpt2 - - - - - - - - - - - - Peptidase_C39,Peptidase_C39_2 k59_860707_1 439235.Dalk_2837 2.59e-76 243.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2WJ3F@28221|Deltaproteobacteria,2MI7I@213118|Desulfobacterales 28221|Deltaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_1646921_1 324057.Pjdr2_3739 1.23e-49 167.0 COG2135@1|root,COG2135@2|Bacteria,1TRRV@1239|Firmicutes,4HDUN@91061|Bacilli,26T4Z@186822|Paenibacillaceae 91061|Bacilli S Belongs to the SOS response-associated peptidase family - - - - - - - - - - - - SRAP k59_131446_1 665571.STHERM_c09050 3.06e-49 162.0 COG5405@1|root,COG5405@2|Bacteria,2J608@203691|Spirochaetes 203691|Spirochaetes O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_131446_2 1121413.JMKT01000011_gene2277 9.67e-71 228.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,42M48@68525|delta/epsilon subdivisions,2WISV@28221|Deltaproteobacteria,2M8IQ@213115|Desulfovibrionales 28221|Deltaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_177248_1 1286170.RORB6_22620 1.55e-141 409.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0000096,GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006556,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009069,GO:0009108,GO:0009116,GO:0009119,GO:0009987,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0019752,GO:0030554,GO:0030955,GO:0031420,GO:0032553,GO:0032555,GO:0032559,GO:0033353,GO:0034641,GO:0035639,GO:0036094,GO:0042278,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046872,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901576,GO:1901605,GO:1901657 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_4967,iYL1228.KPN_03375 S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_1016930_1 1167006.UWK_01789 1.25e-39 147.0 COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,42QFA@68525|delta/epsilon subdivisions,2WK13@28221|Deltaproteobacteria,2MJRY@213118|Desulfobacterales 28221|Deltaproteobacteria M Glycosyl transferase family 4 - - 2.7.8.33,2.7.8.35 ko:K02851 - - R08856 RC00002 ko00000,ko01000,ko01003,ko01005 - - iAF987.Gmet_1505 Glycos_transf_4 k59_84402_2 1121403.AUCV01000001_gene807 3.83e-84 266.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2MI7X@213118|Desulfobacterales 28221|Deltaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_1230607_2 1111729.ATYV01000010_gene206 2.89e-09 62.4 COG1577@1|root,COG1577@2|Bacteria,2IAQ7@201174|Actinobacteria,22MD6@1653|Corynebacteriaceae 201174|Actinobacteria I GHMP kinases C terminal mvk - 2.7.1.36 ko:K00869 ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146 M00095 R02245 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_599164_1 160488.PP_4805 6.82e-60 197.0 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1YWSQ@136845|Pseudomonas putida group 1236|Gammaproteobacteria M lytic murein transglycosylase B mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_338625_1 452637.Oter_0918 3.14e-57 190.0 COG1131@1|root,COG1131@2|Bacteria,46SF6@74201|Verrucomicrobia,3K7X0@414999|Opitutae 74201|Verrucomicrobia V PFAM ABC transporter related - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_338625_2 1384056.N787_01665 4.92e-16 78.2 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1X64I@135614|Xanthomonadales 135614|Xanthomonadales V ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane_3 k59_599168_1 1304885.AUEY01000041_gene3689 1.66e-89 278.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42N89@68525|delta/epsilon subdivisions,2WIUT@28221|Deltaproteobacteria,2MN57@213118|Desulfobacterales 28221|Deltaproteobacteria O Trypsin - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_705500_1 1121937.AUHJ01000026_gene24 5.63e-143 416.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,465EU@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1286259_1 330214.NIDE3190 4e-65 215.0 COG2234@1|root,COG2234@2|Bacteria 2|Bacteria DZ aminopeptidase activity - - - - - - - - - - - - PA,Peptidase_M28 k59_1591590_1 207954.MED92_15835 6.77e-78 243.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1XIQQ@135619|Oceanospirillales 135619|Oceanospirillales M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_1230635_1 1120977.JHUX01000003_gene1692 3.49e-64 216.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria,3NJ0S@468|Moraxellaceae 1236|Gammaproteobacteria P Sulfatase atsA - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_755719_1 1219045.BV98_003327 6.84e-10 60.5 COG0346@1|root,COG0346@2|Bacteria,1RFHY@1224|Proteobacteria,2U8QB@28211|Alphaproteobacteria,2K3SU@204457|Sphingomonadales 204457|Sphingomonadales E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase,Glyoxalase_4 k59_755719_2 487521.OCU_43080 5.4e-89 277.0 COG1063@1|root,COG1063@2|Bacteria,2IBQC@201174|Actinobacteria,23300@1762|Mycobacteriaceae 201174|Actinobacteria E Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_964199_1 1125973.JNLC01000010_gene1409 8.94e-69 225.0 COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria,3JZ96@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_964205_1 1267005.KB911257_gene849 2.22e-38 139.0 COG2227@1|root,COG2227@2|Bacteria,1N3GZ@1224|Proteobacteria,2UD7N@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_23 k59_1440055_1 1247726.MIM_c29580 1.73e-29 107.0 COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,2VVP4@28216|Betaproteobacteria,3T4QR@506|Alcaligenaceae 28216|Betaproteobacteria C Rubredoxin rubA - - - - - - - - - - - Rubredoxin k59_546352_1 472759.Nhal_0146 6.45e-126 375.0 COG0388@1|root,COG0454@1|root,COG0388@2|Bacteria,COG0456@2|Bacteria,1MX4I@1224|Proteobacteria,1RP30@1236|Gammaproteobacteria,1WW4Z@135613|Chromatiales 135613|Chromatiales K Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - - - - - - - - - - Acetyltransf_1,CN_hydrolase k59_392165_1 713586.KB900536_gene2967 7.01e-126 385.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales 135613|Chromatiales K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_705524_1 391735.Veis_1071 1.62e-35 139.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,4A9UD@80864|Comamonadaceae 28216|Betaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_705524_2 641147.HMPREF9021_01323 8.27e-10 62.8 COG2980@1|root,COG2980@2|Bacteria,1PV77@1224|Proteobacteria,2WB4Q@28216|Betaproteobacteria,2KRPN@206351|Neisseriales 206351|Neisseriales M Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane lptE - - ko:K03643 - - - - ko00000,ko02000 1.B.42.1 - - LptE k59_705524_3 713586.KB900536_gene1098 6.23e-91 280.0 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,1WWRB@135613|Chromatiales 135613|Chromatiales L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta k59_1493827_1 1229909.NSED_05495 1.32e-31 115.0 arCOG08805@1|root,arCOG08805@2157|Archaea,41T3X@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_599211_2 1116369.KB890024_gene4566 9.51e-10 57.4 2D1C5@1|root,32TAD@2|Bacteria,1N23F@1224|Proteobacteria,2U94F@28211|Alphaproteobacteria,43NQM@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Ceramidase - - - - - - - - - - - - Ceramidase k59_1647022_1 865861.AZSU01000003_gene2282 4.07e-74 239.0 COG0074@1|root,COG0074@2|Bacteria,1UJ4F@1239|Firmicutes,24AQG@186801|Clostridia,36HIH@31979|Clostridiaceae 186801|Clostridia C Protein of unknown function (DUF1116) - - - ko:K02381 - - - - ko00000 - - - CoA_binding,DUF1116,Ligase_CoA k59_1533053_1 768671.ThimaDRAFT_4548 8.74e-24 98.2 COG1073@1|root,COG1073@2|Bacteria,1R76C@1224|Proteobacteria,1RR34@1236|Gammaproteobacteria,1X0RN@135613|Chromatiales 135613|Chromatiales S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 k59_1533053_2 713586.KB900536_gene2392 6.58e-42 143.0 COG4520@1|root,COG4520@2|Bacteria,1N0YF@1224|Proteobacteria,1SAAR@1236|Gammaproteobacteria,1X1DX@135613|Chromatiales 135613|Chromatiales M 17 kDa outer membrane surface antigen - - - - - - - - - - - - 17kDa_Anti_2,Gly-zipper_Omp,Rick_17kDa_Anti k59_445555_1 330214.NIDE4388 3.01e-87 285.0 COG3002@1|root,COG3002@2|Bacteria,3J0VY@40117|Nitrospirae 40117|Nitrospirae S Uncharacterized protein conserved in bacteria (DUF2309) - - - ko:K09822 - - - - ko00000 - - - DUF2309 k59_1495118_1 1297742.A176_05565 8.37e-89 279.0 COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,42N09@68525|delta/epsilon subdivisions,2WIRX@28221|Deltaproteobacteria,2YUYT@29|Myxococcales 28221|Deltaproteobacteria E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_706463_1 1121918.ARWE01000001_gene228 5.32e-16 82.0 COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,439J4@68525|delta/epsilon subdivisions,2X4VN@28221|Deltaproteobacteria,43UVK@69541|Desulfuromonadales 28221|Deltaproteobacteria NU Type IV Pilus-assembly protein W - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_1287666_1 1229909.NSED_00055 5.97e-79 246.0 COG3276@1|root,arCOG01563@2157|Archaea,41S80@651137|Thaumarchaeota 651137|Thaumarchaeota J Initiation factor - - - ko:K03242 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - GTP_EFTU,eIF2_C k59_1287666_2 1229909.NSED_00060 1.25e-15 71.2 COG1412@1|root,arCOG04312@2157|Archaea,41SUY@651137|Thaumarchaeota 651137|Thaumarchaeota S Nucleotide binding protein, PINc - - - ko:K07158 - - - - ko00000 - - - Fcf1 k59_861793_1 1267533.KB906739_gene2529 1.01e-52 186.0 COG1657@1|root,COG1657@2|Bacteria,3Y37N@57723|Acidobacteria,2JIJP@204432|Acidobacteriia 204432|Acidobacteriia I Squalene-hopene cyclase C-terminal domain - - 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 - R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 - - - SQHop_cyclase_C,SQHop_cyclase_N k59_1441447_1 388051.AUFE01000034_gene3662 2.04e-38 138.0 COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2VJS3@28216|Betaproteobacteria,1KGJZ@119060|Burkholderiaceae 28216|Betaproteobacteria H Aldolase/RraA - - 4.1.3.17 ko:K10218 ko00362,ko00660,ko01120,map00362,map00660,map01120 - R00008,R00350 RC00067,RC00502,RC01205 ko00000,ko00001,ko01000 - - - RraA-like k59_1327538_1 1262449.CP6013_2968 4.12e-07 50.8 COG0730@1|root,COG0730@2|Bacteria,1VAFU@1239|Firmicutes,24MTI@186801|Clostridia,36KJP@31979|Clostridiaceae 186801|Clostridia S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_1327538_2 945713.IALB_1491 1.49e-21 95.1 COG0324@1|root,COG0324@2|Bacteria 2|Bacteria J tRNA dimethylallyltransferase activity miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_85879_1 35128.Thaps22645 1.45e-38 141.0 2EF9S@1|root,2T4ED@2759|Eukaryota,2XEWT@2836|Bacillariophyta 2836|Bacillariophyta - - - - - - - - - - - - - - - k59_11900_1 428125.CLOLEP_02125 5.35e-06 54.3 COG2801@1|root,COG2801@2|Bacteria,1TQQY@1239|Firmicutes,2487W@186801|Clostridia,3WGV7@541000|Ruminococcaceae 186801|Clostridia L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_2 k59_1533086_1 1356852.N008_15435 3.75e-39 147.0 COG0369@1|root,COG0369@2|Bacteria,4NHR8@976|Bacteroidetes,47QP9@768503|Cytophagia 976|Bacteroidetes C Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component cysJ - 1.8.1.2 ko:K00380 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_1,Flavodoxin_1,NAD_binding_1 k59_1648414_1 290315.Clim_2507 4.88e-10 60.1 COG0769@1|root,COG0769@2|Bacteria,1FD5Y@1090|Chlorobi 1090|Chlorobi M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.10,6.3.2.13 ko:K01928,ko:K15792 ko00300,ko00550,map00300,map00550 - R02788,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1648414_2 85643.Tmz1t_3431 4.15e-69 226.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2VH2H@28216|Betaproteobacteria,2KVHS@206389|Rhodocyclales 206389|Rhodocyclales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1495171_1 330214.NIDE1009 3.79e-60 197.0 COG2385@1|root,COG2385@2|Bacteria,3J15K@40117|Nitrospirae 40117|Nitrospirae D Stage II sporulation protein - - - ko:K06381 - - - - ko00000 - - - SpoIID k59_453158_2 1120973.AQXL01000133_gene1747 2.19e-67 223.0 COG0247@1|root,COG0247@2|Bacteria,1TR46@1239|Firmicutes,4HAY9@91061|Bacilli,278U1@186823|Alicyclobacillaceae 91061|Bacilli C 4Fe-4S dicluster domain glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_8 k59_1239343_1 990285.RGCCGE502_34919 4.38e-82 254.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria,4B99W@82115|Rhizobiaceae 28211|Alphaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_826049_1 1229205.BUPH_06076 1.57e-08 54.3 COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2VRN8@28216|Betaproteobacteria,1K4S6@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM CBS domain containing protein - - - - - - - - - - - - CBS k59_668946_1 478741.JAFS01000001_gene2155 1.59e-94 305.0 COG0550@1|root,COG0550@2|Bacteria,46S97@74201|Verrucomicrobia,37G96@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia L Bacterial DNA topoisomeraes I ATP-binding domain topA - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim,Toprim_Crpt k59_510109_1 318996.AXAZ01000051_gene3938 3.02e-67 221.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc k59_1078586_1 1408419.JHYG01000008_gene2289 8.45e-32 122.0 COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,2TSFB@28211|Alphaproteobacteria,2JV5Y@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_1078586_2 1192868.CAIU01000008_gene1179 6.45e-39 132.0 COG1917@1|root,COG1917@2|Bacteria,1N7QJ@1224|Proteobacteria,2UFRZ@28211|Alphaproteobacteria,43KC6@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S PFAM Cupin 2 conserved barrel domain protein MA20_03790 - - ko:K21700 - - - - ko00000 - - - Cupin_2 k59_347039_1 314230.DSM3645_17966 1.1e-85 268.0 COG0129@1|root,COG0129@2|Bacteria,2IWXV@203682|Planctomycetes 203682|Planctomycetes H Belongs to the IlvD Edd family ilvD GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_1388463_1 671143.DAMO_0747 3.64e-75 234.0 COG0022@1|root,COG0022@2|Bacteria,2NNT2@2323|unclassified Bacteria 2|Bacteria C Transketolase, pyrimidine binding domain bfmBA - 1.2.4.4 ko:K00167,ko:K11381,ko:K21417 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_922101_1 399549.Msed_1358 1.53e-23 101.0 COG0179@1|root,arCOG00235@2157|Archaea,2XQQH@28889|Crenarchaeota 28889|Crenarchaeota Q PFAM fumarylacetoacetate (FAA) hydrolase - - - - - - - - - - - - FAA_hydrolase k59_1597891_2 1552758.NC00_18350 1.4e-14 71.6 COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,1S3ZE@1236|Gammaproteobacteria,1X3RK@135614|Xanthomonadales 135614|Xanthomonadales L ADP-ribose diphosphatase nudE - - ko:K08312 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_1176812_1 1002672.SAR11G3_00824 6.8e-86 268.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,4BPNE@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_922104_1 330214.NIDE3732 4.73e-25 98.2 COG0711@1|root,COG0711@2|Bacteria,3J1AE@40117|Nitrospirae 40117|Nitrospirae C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_922104_2 1382306.JNIM01000001_gene2610 1.48e-37 137.0 COG1606@1|root,COG1606@2|Bacteria,2G6AU@200795|Chloroflexi 200795|Chloroflexi L tRNA processing - - - ko:K06864 - - - - ko00000 - - - Asn_synthase,NAD_synthase k59_1388471_1 1229909.NSED_08330 3.74e-144 411.0 COG0714@1|root,arCOG00441@2157|Archaea,41SDZ@651137|Thaumarchaeota 651137|Thaumarchaeota S ATPase family associated with various cellular activities (AAA) - - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5 k59_240484_1 1246474.ANBE01000046_gene4586 9.63e-25 102.0 COG1272@1|root,COG1272@2|Bacteria,2GJGQ@201174|Actinobacteria,4EIGX@85012|Streptosporangiales 201174|Actinobacteria S Haemolysin-III related hlyIII - - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII k59_1078604_1 489825.LYNGBM3L_28410 4.24e-37 133.0 COG4122@1|root,COG4122@2|Bacteria,1G4B7@1117|Cyanobacteria,1HD9H@1150|Oscillatoriales 1117|Cyanobacteria S Methyltransferase domain - - - - - - - - - - - - Methyltransf_24 k59_1078604_2 999411.HMPREF1092_02656 9.11e-11 63.2 COG1215@1|root,COG1215@2|Bacteria,1V0TF@1239|Firmicutes,24N29@186801|Clostridia 186801|Clostridia M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_15325_2 105559.Nwat_0437 2.26e-112 334.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1WVY5@135613|Chromatiales 135613|Chromatiales H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_1388485_1 760142.Hipma_1682 3.48e-21 92.8 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria,2M6TU@213113|Desulfurellales 28221|Deltaproteobacteria E Cys/Met metabolism PLP-dependent enzyme bioF1 - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1388485_2 945713.IALB_1691 4.18e-16 78.6 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_295016_1 443144.GM21_0105 1.06e-85 271.0 COG2010@1|root,COG5557@1|root,COG2010@2|Bacteria,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42PIE@68525|delta/epsilon subdivisions,2WM3C@28221|Deltaproteobacteria,43SBI@69541|Desulfuromonadales 28221|Deltaproteobacteria C Polysulphide reductase, NrfD moz - - ko:K00185 - - - - ko00000 5.A.3 - - DUF3341,NrfD k59_398520_2 395493.BegalDRAFT_2703 1.45e-52 176.0 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,460VX@72273|Thiotrichales 72273|Thiotrichales S Carbon-nitrogen hydrolase - - - ko:K11206 - - - - ko00000,ko01000 - - - CN_hydrolase k59_553474_1 398527.Bphyt_5121 1.98e-63 209.0 COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2VHV4@28216|Betaproteobacteria,1K04S@119060|Burkholderiaceae 28216|Betaproteobacteria E peptidase dimerisation domain protein - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_1176836_1 237368.SCABRO_01637 1.61e-13 70.9 COG0058@1|root,COG0058@2|Bacteria,2IY0J@203682|Planctomycetes 203682|Planctomycetes G COG0058 Glucan phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_922133_1 379066.GAU_0001 3.05e-106 322.0 COG0593@1|root,COG0593@2|Bacteria,1ZSQ2@142182|Gemmatimonadetes 142182|Gemmatimonadetes L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_605564_1 204669.Acid345_1270 5.51e-87 275.0 COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia 204432|Acidobacteriia Q Flavin containing amine oxidoreductase - - - - - - - - - - - - NAD_binding_8 k59_1024456_1 525904.Tter_2149 3.28e-09 64.7 COG2132@1|root,COG4454@1|root,COG2132@2|Bacteria,COG4454@2|Bacteria,2NPCW@2323|unclassified Bacteria 2|Bacteria PQ Multicopper oxidase nirK GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1 ko:K00368,ko:K18683 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Copper-bind,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1,Cytochrom_C,Cytochrome_CBB3 k59_1389367_1 754476.Q7A_1387 7.47e-22 95.1 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,45ZUG@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_1079860_1 517417.Cpar_1493 8.13e-100 295.0 COG0588@1|root,COG0588@2|Bacteria,1FDHF@1090|Chlorobi 1090|Chlorobi F Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmA - 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_670262_1 1121935.AQXX01000073_gene303 1.02e-33 130.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1XHM6@135619|Oceanospirillales 135619|Oceanospirillales S Permease lptF - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_348368_1 1380394.JADL01000003_gene5081 5.11e-40 150.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,2JR1T@204441|Rhodospirillales 204441|Rhodospirillales T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - Guanylate_cyc,TPR_19 k59_1333942_1 929703.KE386491_gene3961 4.44e-24 98.6 COG4539@1|root,COG4539@2|Bacteria,4NQIX@976|Bacteroidetes,47Q6B@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function (DUF962) - - - - - - - - - - - - DUF962 k59_94897_1 5286.M7WT85 6.81e-06 53.1 KOG0254@1|root,KOG0254@2759|Eukaryota,38FTM@33154|Opisthokonta,3NUY9@4751|Fungi,3UZE7@5204|Basidiomycota,2YCMI@29000|Pucciniomycotina 4751|Fungi U Sugar (and other) transporter - - - - - - - - - - - - MFS_1 k59_94897_2 997346.HMPREF9374_2151 5.73e-10 60.5 COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,4HA2U@91061|Bacilli,27CKY@186824|Thermoactinomycetaceae 91061|Bacilli P Binding-protein-dependent transport system inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_923321_2 3218.PP1S30_253V6.1 5.94e-22 94.0 COG1225@1|root,KOG0855@2759|Eukaryota,37NM1@33090|Viridiplantae,3GD6X@35493|Streptophyta 35493|Streptophyta O Peroxiredoxin Q - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_1297233_1 991905.SL003B_2986 3.6e-150 438.0 COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2TRU8@28211|Alphaproteobacteria,4BPMM@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Bacterial protein of unknown function (DUF853) yjgR - - ko:K06915 - - - - ko00000 - - - DUF853 k59_670276_1 99598.Cal7507_0388 1.39e-24 108.0 COG2114@1|root,COG2203@1|root,COG5002@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,1G1PT@1117|Cyanobacteria,1HMW9@1161|Nostocales 1117|Cyanobacteria T Adenylate guanylate cyclase with GAF and PAS PAC sensors - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - GAF,Guanylate_cyc,PAS,PAS_8,PAS_9 k59_1177751_1 1304275.C41B8_05408 1.72e-112 334.0 2DVPY@1|root,33WQ8@2|Bacteria,1N9VQ@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1539139_2 1123377.AUIV01000007_gene1277 1.31e-09 63.5 2B3X8@1|root,31WM6@2|Bacteria,1RFUV@1224|Proteobacteria,1RNAH@1236|Gammaproteobacteria,1X5HH@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF3999) - - - - - - - - - - - - DUF3999 k59_1504893_1 395494.Galf_0315 5.37e-54 188.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,44V3U@713636|Nitrosomonadales 28216|Betaproteobacteria V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA - - ko:K02021,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran k59_1447992_1 313606.M23134_04333 3.12e-07 53.5 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1 k59_1240387_1 443144.GM21_0445 8.75e-28 117.0 COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,42XJ0@68525|delta/epsilon subdivisions,2WT3A@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - - - - - - - - - - TonB_C k59_670299_1 716928.AJQT01000034_gene852 1.77e-07 55.1 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2TSWX@28211|Alphaproteobacteria,4BAA8@82115|Rhizobiaceae 28211|Alphaproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_670299_2 1121918.ARWE01000001_gene152 1.74e-07 55.5 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,42P2T@68525|delta/epsilon subdivisions,2WJ9B@28221|Deltaproteobacteria,43S8A@69541|Desulfuromonadales 28221|Deltaproteobacteria JK 16S rRNA methyltransferase RsmB/F rsmB - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_606388_1 1159870.KB907784_gene428 7.15e-59 206.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,3T1BB@506|Alcaligenaceae 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA2 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_511514_1 519989.ECTPHS_01134 6.54e-83 268.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales 135613|Chromatiales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_1177767_1 1229780.BN381_290074 2.12e-83 256.0 COG0208@1|root,COG0208@2|Bacteria 2|Bacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - - - - - - - - - - - Ald_deCOase k59_1177767_2 1229780.BN381_290075 2.91e-57 187.0 COG0208@1|root,COG0208@2|Bacteria 2|Bacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - - - - - - - - - - - Ald_deCOase k59_1240395_1 448385.sce6663 9.02e-85 258.0 COG2267@1|root,COG2267@2|Bacteria,1MYEX@1224|Proteobacteria,43CP1@68525|delta/epsilon subdivisions,2X7WC@28221|Deltaproteobacteria,2Z2N6@29|Myxococcales 28221|Deltaproteobacteria I hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_1 k59_670317_1 543913.D521_1841 8.34e-99 298.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2VH1J@28216|Betaproteobacteria,1KQD9@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_348422_1 179408.Osc7112_5083 3.04e-45 162.0 COG3957@1|root,COG3957@2|Bacteria,1G0B2@1117|Cyanobacteria,1H7CT@1150|Oscillatoriales 1117|Cyanobacteria G D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase - - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_348422_2 1232410.KI421424_gene1795 4.33e-51 169.0 COG0637@1|root,COG0637@2|Bacteria 2|Bacteria S phosphonoacetaldehyde hydrolase activity pgmB GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008801,GO:0009058,GO:0009292,GO:0009294,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0019203,GO:0030312,GO:0033554,GO:0034637,GO:0040007,GO:0042221,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046351,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0071704,GO:0071944,GO:1901576 2.4.1.64,3.1.3.12,3.2.1.28,5.4.2.6 ko:K01087,ko:K01194,ko:K01838,ko:K05342 ko00500,ko01100,map00500,map01100 - R00010,R02727,R02728,R02778,R11310 RC00017,RC00049,RC00408 ko00000,ko00001,ko00537,ko01000 - GH37,GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Hydrolase,Trehalose_PPase k59_1389421_2 1131730.BAVI_24338 1.45e-26 108.0 COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,4HCE7@91061|Bacilli,1ZC3Z@1386|Bacillus 91061|Bacilli V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_1539177_1 998674.ATTE01000001_gene824 3.84e-63 207.0 COG0477@1|root,COG2814@2|Bacteria,1N2NP@1224|Proteobacteria,1RP1Y@1236|Gammaproteobacteria,4622I@72273|Thiotrichales 72273|Thiotrichales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_713562_1 522772.Dacet_2513 1.91e-36 141.0 COG0183@1|root,COG0183@2|Bacteria,2GF0X@200930|Deferribacteres 200930|Deferribacteres I Thiolase, C-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_868219_1 349521.HCH_03018 4.98e-49 175.0 COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,1RPGN@1236|Gammaproteobacteria,1XHHM@135619|Oceanospirillales 135619|Oceanospirillales MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1297306_1 1122603.ATVI01000011_gene2111 5.19e-61 208.0 COG1257@1|root,COG1577@1|root,COG1257@2|Bacteria,COG1577@2|Bacteria,1MXVE@1224|Proteobacteria,1RS9R@1236|Gammaproteobacteria,1X8RF@135614|Xanthomonadales 135614|Xanthomonadales I Hydroxymethylglutaryl-coenzyme A reductase - - 1.1.1.88 ko:K00054 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R02081 RC00004,RC00644 ko00000,ko00001,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N,HMG-CoA_red k59_1131991_1 1229909.NSED_07500 1.25e-30 107.0 arCOG10403@1|root,arCOG10403@2157|Archaea,41TB3@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1131991_2 436308.Nmar_1369 3.51e-27 99.4 arCOG08651@1|root,arCOG08651@2157|Archaea,41TB6@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1079950_1 290512.Paes_0581 7.52e-27 102.0 COG0758@1|root,COG0758@2|Bacteria,1FE5W@1090|Chlorobi 1090|Chlorobi LU Putative molybdenum carrier - - - - - - - - - - - - MoCo_carrier k59_1079950_2 1122621.ATZA01000024_gene2189 3.61e-34 129.0 COG0025@1|root,COG0025@2|Bacteria,4NF54@976|Bacteroidetes,1IPW7@117747|Sphingobacteriia 976|Bacteroidetes P PFAM sodium hydrogen exchanger nhaP - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger k59_399401_2 1232410.KI421413_gene655 4.23e-42 153.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,43UET@69541|Desulfuromonadales 28221|Deltaproteobacteria G Carbohydrate phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_923406_1 1121403.AUCV01000010_gene1363 1.03e-84 261.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MDC@68525|delta/epsilon subdivisions,2WJM7@28221|Deltaproteobacteria,2MHWR@213118|Desulfobacterales 28221|Deltaproteobacteria E Belongs to the DegT DnrJ EryC1 family - - 2.6.1.102,2.6.1.109 ko:K13010,ko:K19715 ko00520,map00520 - R10460,R11395 RC00006,RC00160,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k59_184363_2 56780.SYN_01697 1.26e-68 213.0 COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria 1224|Proteobacteria I Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length fabA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016863,GO:0019171,GO:0019752,GO:0032787,GO:0034017,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b0954,iB21_1397.B21_00965,iBWG_1329.BWG_0806,iE2348C_1286.E2348C_0940,iEC042_1314.EC042_1039,iECBD_1354.ECBD_2641,iECB_1328.ECB_00958,iECDH10B_1368.ECDH10B_1024,iECD_1391.ECD_00958,iECED1_1282.ECED1_0977,iECH74115_1262.ECH74115_1118,iECIAI1_1343.ECIAI1_0995,iECIAI39_1322.ECIAI39_2193,iECNA114_1301.ECNA114_1032,iECO103_1326.ECO103_1000,iECO111_1330.ECO111_1022,iECO26_1355.ECO26_1081,iECOK1_1307.ECOK1_1013,iECS88_1305.ECS88_0975,iECSF_1327.ECSF_0868,iECSP_1301.ECSP_1060,iECUMN_1333.ECUMN_1143,iECW_1372.ECW_m1064,iECs_1301.ECs1038,iEKO11_1354.EKO11_2876,iETEC_1333.ETEC_1024,iEcE24377_1341.EcE24377A_1068,iEcHS_1320.EcHS_A1063,iEcSMS35_1347.EcSMS35_2166,iEcolC_1368.EcolC_2642,iG2583_1286.G2583_1189,iJO1366.b0954,iJR904.b0954,iLF82_1304.LF82_0604,iSBO_1134.SBO_2277,iSDY_1059.SDY_0927,iSF_1195.SF0954,iSSON_1240.SSON_0958,iSbBS512_1146.SbBS512_E2362,iUMNK88_1353.UMNK88_1108,iWFL_1372.ECW_m1064,iY75_1357.Y75_RS04955,iZ_1308.Z1304,ic_1306.c1090 FabA k59_606421_1 222534.KB893670_gene3802 7.76e-71 231.0 COG4310@1|root,COG4310@2|Bacteria,2GK72@201174|Actinobacteria,4EUY6@85013|Frankiales 201174|Actinobacteria S Domain of unknown function (DUF2172) - - - - - - - - - - - - DUF2172,DUF4910,HTH_47,Peptidase_M28 k59_615368_1 1499967.BAYZ01000073_gene2041 2.01e-17 81.6 COG0552@1|root,COG0552@2|Bacteria,2NP66@2323|unclassified Bacteria 2|Bacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_615368_2 926692.AZYG01000034_gene2372 4.05e-43 152.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,3WAED@53433|Halanaerobiales 186801|Clostridia H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_193271_1 1459636.NTE_02338 2.91e-37 135.0 COG1681@1|root,arCOG01829@2157|Archaea 2157|Archaea N Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella flaB1 GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - ko:K07324,ko:K07325 - - - - ko00000,ko02035,ko02044 - - - Arch_flagellin k59_932850_1 1089550.ATTH01000001_gene473 1.32e-43 151.0 COG4314@1|root,COG4314@2|Bacteria,4NIPU@976|Bacteroidetes,1FJJY@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C lipoprotein involved in nitrous oxide reduction - - - ko:K19342 - - - - ko00000 - - - NosL k59_463087_1 113355.CM001775_gene393 1.21e-16 85.9 COG0438@1|root,COG0438@2|Bacteria,1G4XB@1117|Cyanobacteria 1117|Cyanobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - k59_771852_2 1499967.BAYZ01000076_gene830 3.52e-73 228.0 COG1651@1|root,COG1651@2|Bacteria 2|Bacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - - - - - - - - - - Thioredoxin_4 k59_1185489_1 1078020.KEK_00640 3.89e-28 108.0 2E7BU@1|root,331V4@2|Bacteria,2GQ2K@201174|Actinobacteria,23DX1@1762|Mycobacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1090853_1 1095769.CAHF01000011_gene2579 3.64e-18 87.8 COG2199@1|root,COG3706@2|Bacteria,1R59V@1224|Proteobacteria,2VN7N@28216|Betaproteobacteria,473WE@75682|Oxalobacteraceae 28216|Betaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - GGDEF,Response_reg k59_1143421_2 565045.NOR51B_2163 7.38e-74 240.0 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,1RNBI@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_195036_1 331869.BAL199_15643 5.94e-21 85.9 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2U5SV@28211|Alphaproteobacteria,4BSBP@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Endoribonuclease L-PSP MA20_29855 - - ko:K09021 ko00240,ko01100,map00240,map01100 - R09982 RC02768 ko00000,ko00001 - - - Ribonuc_L-PSP k59_1143448_1 713587.THITH_12355 5.21e-118 352.0 28K6U@1|root,2Z9V7@2|Bacteria,1MYVN@1224|Proteobacteria,1S0GU@1236|Gammaproteobacteria,1WW9K@135613|Chromatiales 135613|Chromatiales S TIGRFAM carboxysome shell carbonic anhydrase - - - - - - - - - - - - CsoSCA k59_1457409_1 1229909.NSED_01530 8.02e-104 310.0 COG0148@1|root,arCOG01169@2157|Archaea,41SE9@651137|Thaumarchaeota 651137|Thaumarchaeota G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_773056_1 83406.HDN1F_04230 3.94e-111 334.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4G2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains cbrB - - - - - - - - - - - Response_reg,Sigma54_activat k59_773056_2 329726.AM1_3565 2.16e-18 87.8 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1G0EM@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA k59_1187131_1 1207063.P24_02181 2.38e-29 115.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2TSK2@28211|Alphaproteobacteria,2JPCR@204441|Rhodospirillales 204441|Rhodospirillales S NMT1-like family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_980816_1 402881.Plav_0960 9.15e-38 145.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,1JN93@119043|Rhodobiaceae 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_617154_1 378806.STAUR_4045 4.27e-30 122.0 COG1165@1|root,COG1165@2|Bacteria,1MVMZ@1224|Proteobacteria,42PNC@68525|delta/epsilon subdivisions,2WKSZ@28221|Deltaproteobacteria,2YUJF@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) menD - 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N k59_980827_2 941639.BCO26_0106 1.85e-53 174.0 COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,4HAK4@91061|Bacilli,1ZB14@1386|Bacillus 91061|Bacilli J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_1549822_1 521674.Plim_1175 1.14e-13 70.9 COG0071@1|root,COG0071@2|Bacteria 2|Bacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_1143488_1 555079.Toce_0327 2.6e-45 162.0 COG1820@1|root,COG1820@2|Bacteria,1TPFK@1239|Firmicutes,2481N@186801|Clostridia,42FJJ@68295|Thermoanaerobacterales 186801|Clostridia G Belongs to the metallo-dependent hydrolases superfamily. NagA family nagA - 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 - R02059 RC00166,RC00300 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_1457427_1 1229909.NSED_02485 6.75e-102 307.0 COG0719@1|root,arCOG01715@2157|Archaea,41S7W@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly protein SufD - - - ko:K09014,ko:K09015 - - - - ko00000 - - - UPF0051 k59_980833_1 338966.Ppro_2547 2.04e-25 105.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,42S9I@68525|delta/epsilon subdivisions,2WNTW@28221|Deltaproteobacteria,43TCT@69541|Desulfuromonadales 28221|Deltaproteobacteria D Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_20375_1 298653.Franean1_7333 2.63e-25 108.0 COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria,4ERFS@85013|Frankiales 201174|Actinobacteria D PFAM Cobyrinic acid a,c-diamide synthase parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_564797_1 653733.Selin_0159 1.86e-65 224.0 COG0458@1|root,COG0458@2|Bacteria 2|Bacteria F carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS k59_1034836_1 445686.E3SL53_9CAUD 1.24e-91 275.0 4QCS3@10239|Viruses,4QY7T@35237|dsDNA viruses no RNA stage,4QU2E@28883|Caudovirales,4QKJF@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1034836_2 268746.Q58MN3_BPPRM 9.35e-18 82.8 4QDJF@10239|Viruses,4QVQ0@35237|dsDNA viruses no RNA stage,4QR89@28883|Caudovirales,4QICF@10662|Myoviridae 10662|Myoviridae S Virus neck protein - GO:0005575,GO:0019012 - - - - - - - - - - - k59_1090949_1 1123261.AXDW01000018_gene806 6.54e-26 112.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RN6S@1236|Gammaproteobacteria,1X3SK@135614|Xanthomonadales 135614|Xanthomonadales C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_878426_1 436308.Nmar_0295 5.92e-92 284.0 COG1245@1|root,arCOG00187@2157|Archaea,41S8K@651137|Thaumarchaeota 651137|Thaumarchaeota E RNase L inhibitor, RLI - - - ko:K06174 - - - - ko00000,ko03009 - - - ABC_tran,Fer4,RLI k59_1398873_2 247490.KSU1_C0518 7.04e-09 58.5 COG1801@1|root,COG1801@2|Bacteria,2IYWM@203682|Planctomycetes 203682|Planctomycetes S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 k59_564805_1 582744.Msip34_2332 4.8e-13 69.7 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,2KKRZ@206350|Nitrosomonadales 206350|Nitrosomonadales H PFAM MoeA domain protein domain I and II - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_564805_2 395493.BegalDRAFT_1915 1.5e-26 104.0 COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,1S72P@1236|Gammaproteobacteria 1236|Gammaproteobacteria H molybdopterin-guanine dinucleotide biosynthesis protein mobB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.7.7.77 ko:K03753,ko:K13818 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - iB21_1397.B21_03691,iBWG_1329.BWG_3527,iECBD_1354.ECBD_4174,iECDH1ME8569_1439.ECDH1ME8569_3728,iEcDH1_1363.EcDH1_4130,iJO1366.b3856,iSbBS512_1146.SbBS512_E4328,iY75_1357.Y75_RS17805 MobB k59_617219_1 1380391.JIAS01000011_gene5159 2.16e-115 343.0 COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2TRWC@28211|Alphaproteobacteria,2JQUP@204441|Rhodospirillales 204441|Rhodospirillales E IMP dehydrogenase / GMP reductase domain - - 2.1.1.21 ko:K22083 ko00680,ko01120,map00680,map01120 - R01586 RC00554 ko00000,ko00001,ko01000 - - - Glu_synthase k59_251931_1 436308.Nmar_0651 2.98e-32 130.0 COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota 651137|Thaumarchaeota D SMC proteins Flexible Hinge Domain - - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_564811_1 1406840.Q763_05775 1.02e-22 97.1 COG2249@1|root,COG2249@2|Bacteria,4NGF7@976|Bacteroidetes,1HZV2@117743|Flavobacteriia,2NUZ5@237|Flavobacterium 976|Bacteroidetes S NAD(P)H oxidoreductase yheR - - ko:K11748 - - - - ko00000,ko02000 2.A.37.1.2 - - Flavodoxin_2 k59_1250208_1 1283284.AZUK01000001_gene1853 2.15e-42 159.0 COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,1MXH9@1224|Proteobacteria,1RPQ6@1236|Gammaproteobacteria,1Y55X@135624|Aeromonadales 135624|Aeromonadales S Lysylphosphatidylglycerol synthase TM region - - 2.3.2.3 ko:K14205 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 - - ko00000,ko00001,ko00002,ko01000,ko01504 2.A.1.3.37 - - DUF2156,LPG_synthase_TM k59_1549878_2 1449048.JQKU01000018_gene4334 2.34e-31 122.0 COG2838@1|root,COG2838@2|Bacteria,2GJ1C@201174|Actinobacteria,233H0@1762|Mycobacteriaceae 201174|Actinobacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_1606689_1 436308.Nmar_1368 3.05e-74 229.0 COG0457@1|root,arCOG03038@2157|Archaea,41SMV@651137|Thaumarchaeota 651137|Thaumarchaeota S Transglutaminase-like superfamily - - - - - - - - - - - - TPR_9,Transglut_core2 k59_724045_1 1116232.AHBF01000113_gene4574 2.07e-33 129.0 COG0002@1|root,COG0002@2|Bacteria,2GKDU@201174|Actinobacteria 201174|Actinobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde - - - - - - - - - - - - Semialdhyde_dh,Semialdhyde_dhC k59_1343455_1 243233.MCA0596 5.31e-142 410.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1THGR@1236|Gammaproteobacteria,1XDV9@135618|Methylococcales 135618|Methylococcales E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1090997_1 1121940.AUDZ01000005_gene1530 3.81e-14 77.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1XIVR@135619|Oceanospirillales 135619|Oceanospirillales KL helicase dinG - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,ResIII k59_1187224_1 521719.ATXQ01000001_gene513 7.77e-73 239.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1YE7S@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L May be involved in recombinational repair of damaged DNA recN GO:0000724,GO:0000725,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_1187224_2 1158338.JNLJ01000001_gene682 8.39e-49 161.0 COG1246@1|root,COG1246@2|Bacteria,2G4ZU@200783|Aquificae 200783|Aquificae E Acetyltransferase (GNAT) domain - - 2.3.1.1 ko:K00619 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1 k59_151090_1 549.BW31_00387 2.04e-09 57.8 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,3VXSY@53335|Pantoea 1236|Gammaproteobacteria F DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_464785_2 1144275.COCOR_06201 7.29e-12 64.7 28S5K@1|root,2ZEH5@2|Bacteria,1NI42@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (FYDLN_acid) - - - - - - - - - - - - FYDLN_acid k59_464785_3 649638.Trad_0907 1.94e-47 169.0 COG4284@1|root,COG4284@2|Bacteria 2|Bacteria G Utp--glucose-1-phosphate uridylyltransferase CP_1013 - 2.7.7.23,2.7.7.83 ko:K00972,ko:K11442 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00361,M00362 R00416 RC00002 ko00000,ko00001,ko00002,ko01000 - - - UDPGP k59_20407_1 216432.CA2559_03260 1.7e-109 330.0 COG1233@1|root,COG1233@2|Bacteria,4NF31@976|Bacteroidetes,1HYWT@117743|Flavobacteriia 976|Bacteroidetes Q Flavin containing amine oxidoreductase pys - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_617264_1 1219084.AP014508_gene148 5.85e-37 134.0 COG2513@1|root,COG2513@2|Bacteria 2|Bacteria G methylisocitrate lyase activity prpB - 4.1.3.30,4.1.3.32 ko:K03417,ko:K20454 ko00640,ko00760,ko01120,map00640,map00760,map01120 - R00409,R01355 RC00286,RC00287,RC01810 ko00000,ko00001,ko01000 - - - PEP_mutase k59_1606701_1 1265490.JHVY01000018_gene268 2.19e-28 112.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Peptidase, M16 pqqL - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1606701_2 398579.Spea_3980 4.6e-34 133.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,2QAA0@267890|Shewanellaceae 1236|Gammaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019897,GO:0019898,GO:0031224,GO:0031226,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033036,GO:0033365,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_151094_1 551895.B5AX46_9CAUD 2.39e-19 92.8 4QB41@10239|Viruses,4QVVT@35237|dsDNA viruses no RNA stage,4QQ01@28883|Caudovirales,4QHYB@10662|Myoviridae 10662|Myoviridae S Uncharacterized protein conserved in bacteria (DUF2213) - - - - - - - - - - - - - k59_359267_1 391623.TERMP_00051 3.64e-65 202.0 COG0537@1|root,arCOG00419@2157|Archaea,2XWGT@28890|Euryarchaeota,242M1@183968|Thermococci 183968|Thermococci F Hit family - - 2.7.7.53 ko:K19710 ko00230,map00230 - R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 - - - HIT k59_980951_1 1292035.H476_0593 8.32e-08 57.8 COG3944@1|root,COG3944@2|Bacteria,1UZCR@1239|Firmicutes,24HS8@186801|Clostridia,25RZQ@186804|Peptostreptococcaceae 186801|Clostridia M Chain length determinant protein - - - - - - - - - - - - GNVR,Wzz k59_1549935_2 436308.Nmar_1265 1.01e-29 110.0 COG0494@1|root,arCOG01072@2157|Archaea,41STX@651137|Thaumarchaeota 651137|Thaumarchaeota L NUDIX domain - - - - - - - - - - - - NUDIX k59_1143634_1 876044.IMCC3088_707 4.11e-45 169.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1J4NF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_151128_1 323848.Nmul_A2659 4.23e-40 139.0 COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,2VPKX@28216|Betaproteobacteria,3728P@32003|Nitrosomonadales 28216|Betaproteobacteria C PFAM NapC NirT cytochrome c napC - - ko:K02569 - - - - ko00000 - - - Cytochrom_NNT k59_1549944_1 443143.GM18_0341 2.85e-93 294.0 COG2133@1|root,COG2133@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - - - - - - - - - - - k59_564867_1 1410668.JNKC01000003_gene443 1.75e-15 83.6 COG1408@1|root,COG1408@2|Bacteria,1TS43@1239|Firmicutes,248XA@186801|Clostridia,36WWR@31979|Clostridiaceae 186801|Clostridia S PFAM Metallophosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos k59_307345_1 1121459.AQXE01000001_gene2751 1.72e-69 221.0 28IR7@1|root,2Z8QR@2|Bacteria,1PBTP@1224|Proteobacteria,42Z7V@68525|delta/epsilon subdivisions,2WTZ3@28221|Deltaproteobacteria,2M8NA@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1549950_1 1122212.AULO01000014_gene1251 4.56e-115 365.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1XHCD@135619|Oceanospirillales 135619|Oceanospirillales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_53268_1 266265.Bxe_A2072 1.99e-23 96.3 COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,2VIWQ@28216|Betaproteobacteria,1K08A@119060|Burkholderiaceae 28216|Betaproteobacteria H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186,ko:K16875 ko00130,ko00365,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00365,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R10213,R11225 RC00391,RC00814,RC03086,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_53268_2 1265310.CCBD010000015_gene3680 1.2e-06 50.8 COG1804@1|root,COG1804@2|Bacteria,2GMIW@201174|Actinobacteria,238E1@1762|Mycobacteriaceae 201174|Actinobacteria C carnitine dehydratase - - - - - - - - - - - - CoA_transf_3 k59_1097792_1 1121904.ARBP01000053_gene480 4.65e-89 280.0 COG0833@1|root,COG0833@2|Bacteria,4PPC8@976|Bacteroidetes 976|Bacteroidetes E Amino acid permease - - - ko:K11733 - - - - ko00000,ko02000 2.A.3.1.2 - - AA_permease k59_1358990_1 1121937.AUHJ01000002_gene3612 4.01e-44 149.0 COG3467@1|root,COG3467@2|Bacteria,1N17U@1224|Proteobacteria,1SA1T@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Pfam:Pyridox_oxidase - - - - - - - - - - - - Putative_PNPOx k59_732167_1 653733.Selin_2501 1.96e-118 357.0 COG0415@1|root,COG0415@2|Bacteria 2|Bacteria L Belongs to the DNA photolyase family phrB GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0006139,GO:0006259,GO:0006281,GO:0006464,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0018298,GO:0019538,GO:0033554,GO:0034641,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901564 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_732167_3 391625.PPSIR1_40710 3.07e-85 265.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria,2Z21X@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the ferrous insertion into protoporphyrin IX hemH GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_209710_1 1196322.A370_03359 5.29e-09 60.5 COG2931@1|root,COG2931@2|Bacteria,1TSGB@1239|Firmicutes,247TS@186801|Clostridia,36F14@31979|Clostridiaceae 186801|Clostridia Q PFAM Collagen triple helix repeat - - - - - - - - - - - - Collagen k59_627882_1 314278.NB231_05851 5.64e-94 286.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1WWUV@135613|Chromatiales 135613|Chromatiales E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1202468_2 983545.Glaag_0506 2.14e-45 162.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,464P4@72275|Alteromonadaceae 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360 - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_575462_1 395493.BegalDRAFT_3285 1.61e-168 493.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,4601N@72273|Thiotrichales 72273|Thiotrichales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_1149965_1 1206733.BAGC01000008_gene5357 0.000167 50.4 COG0596@1|root,COG0596@2|Bacteria,2IR0S@201174|Actinobacteria,4G8KW@85025|Nocardiaceae 201174|Actinobacteria S Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1 k59_262050_1 314225.ELI_11060 1.78e-06 52.0 COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,2U874@28211|Alphaproteobacteria,2K179@204457|Sphingomonadales 204457|Sphingomonadales O COG0760 Parvulin-like peptidyl-prolyl isomerase - - - - - - - - - - - - Rotamase_2 k59_262050_2 1137799.GZ78_22325 6.4e-55 194.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,1XMWY@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_314280_1 1131553.JIBI01000015_gene640 6.74e-41 147.0 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,2VJXV@28216|Betaproteobacteria,371P8@32003|Nitrosomonadales 28216|Betaproteobacteria M Copper binding periplasmic protein CusF cusB - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - CusF_Ec,HlyD_D23 k59_314280_2 1049564.TevJSym_ae01230 7.18e-19 85.5 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1J7RP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_784583_1 862908.BMS_2717 2.31e-10 62.8 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,42PC9@68525|delta/epsilon subdivisions,2WKA4@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Na dependent nucleoside transporter - - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_784583_2 1382359.JIAL01000001_gene2421 5.38e-08 55.8 COG0352@1|root,COG0352@2|Bacteria,3Y4Y5@57723|Acidobacteria,2JJM3@204432|Acidobacteriia 204432|Acidobacteriia H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_314283_1 857087.Metme_0456 2.09e-77 256.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1XEJP@135618|Methylococcales 135618|Methylococcales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1463455_1 1229909.NSED_04950 1.07e-150 433.0 COG1503@1|root,arCOG01742@2157|Archaea,41SEK@651137|Thaumarchaeota 651137|Thaumarchaeota J Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA prf1 - - ko:K03265 ko03015,map03015 - - - ko00000,ko00001,ko03012,ko03019 - - - eRF1_1,eRF1_2,eRF1_3 k59_470825_1 555088.DealDRAFT_1634 3.72e-11 63.9 COG1208@1|root,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,24AGU@186801|Clostridia,42K9R@68298|Syntrophomonadaceae 186801|Clostridia M transferase hexapeptide repeat containing protein - - 2.7.7.13 ko:K00966 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_470825_2 161156.JQKW01000006_gene1175 4.55e-09 63.2 COG3178@1|root,COG3178@2|Bacteria,2GHXN@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria JM Ecdysteroid kinase - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH,NTP_transferase k59_314284_1 95619.PM1_0204990 2.13e-40 150.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iECOK1_1307.ECOK1_0652,iECS88_1305.ECS88_0684,iNRG857_1313.NRG857_02925,iPC815.YPO2610 Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_314284_2 1026882.MAMP_02897 1e-10 64.3 COG2980@1|root,COG2980@2|Bacteria,1NGPX@1224|Proteobacteria,1SGKQ@1236|Gammaproteobacteria,461AA@72273|Thiotrichales 72273|Thiotrichales M Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane lptE - - ko:K03643 - - - - ko00000,ko02000 1.B.42.1 - - LptE k59_784598_1 1122611.KB903941_gene2137 1.16e-49 167.0 COG1024@1|root,COG1024@2|Bacteria,2HEIS@201174|Actinobacteria,4EGEZ@85012|Streptosporangiales 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_157316_1 1304275.C41B8_16724 1.81e-19 86.3 COG4968@1|root,COG4968@2|Bacteria,1N31J@1224|Proteobacteria,1SS17@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Prokaryotic N-terminal methylation motif - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl k59_418750_1 649638.Trad_0059 4.69e-68 214.0 COG3153@1|root,COG3153@2|Bacteria,1WJBH@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 k59_732191_2 472759.Nhal_2285 4.75e-36 139.0 COG3746@1|root,COG3746@2|Bacteria,1RA39@1224|Proteobacteria,1S2UH@1236|Gammaproteobacteria,1WYPZ@135613|Chromatiales 135613|Chromatiales P PFAM Phosphate-selective porin O and P - - - ko:K07221 - - - - ko00000,ko02000 1.B.5.1 - - Porin_O_P k59_732192_1 479434.Sthe_1835 2.62e-10 58.9 COG1622@1|root,COG1622@2|Bacteria,2G8QU@200795|Chloroflexi,27YGH@189775|Thermomicrobia 200795|Chloroflexi C Cytochrome c oxidase - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2 k59_53316_1 240015.ACP_2341 1.06e-67 214.0 COG0040@1|root,COG0040@2|Bacteria,3Y31Q@57723|Acidobacteria,2JICU@204432|Acidobacteriia 204432|Acidobacteriia E ATP phosphoribosyltransferase hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_1306594_1 998674.ATTE01000001_gene4298 1.04e-66 207.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,1RNEV@1236|Gammaproteobacteria,460ID@72273|Thiotrichales 72273|Thiotrichales J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_1306594_2 580332.Slit_0783 3.1e-44 147.0 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2VSH0@28216|Betaproteobacteria,44W0K@713636|Nitrosomonadales 28216|Betaproteobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_1306594_3 2340.JV46_07220 1.53e-59 189.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,1J5Q4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_262076_1 1191523.MROS_0406 5.73e-27 106.0 COG0492@1|root,COG0492@2|Bacteria 2|Bacteria C ferredoxin-NADP+ reductase activity trxB GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 ko:K00384,ko:K03671 ko00450,ko04621,ko05418,map00450,map04621,map05418 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000,ko03110 - - iNJ661.Rv3913 Pyr_redox_2,Thioredoxin k59_262076_2 1131269.AQVV01000001_gene1406 1.37e-38 151.0 COG0404@1|root,COG0457@1|root,COG3071@1|root,COG0404@2|Bacteria,COG0457@2|Bacteria,COG3071@2|Bacteria 2|Bacteria H HemY protein ygfZ - 1.5.3.1,2.1.2.10,3.1.21.3 ko:K00305,ko:K00605,ko:K01153,ko:K02498,ko:K06980 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R00610,R01221,R02300,R04125 RC00022,RC00060,RC00069,RC00183,RC00557,RC02834 ko00000,ko00001,ko00002,ko01000,ko02048,ko03016 - - - DUF2905,GCV_T,GCV_T_C k59_53346_1 352165.HMPREF7215_2591 9.79e-32 125.0 COG5410@1|root,COG5410@2|Bacteria 2|Bacteria K chromosome segregation - - - - - - - - - - - - Terminase_6,Terminase_6C k59_366606_2 1449353.JQMQ01000005_gene5520 2.85e-64 210.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,2NEQU@228398|Streptacidiphilus 201174|Actinobacteria C CoA-transferase family III - - 2.8.3.15 ko:K07544 ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220 M00418 R05588 RC00014,RC00137 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_784632_1 443152.MDG893_07985 2.19e-35 130.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,464FH@72275|Alteromonadaceae 1236|Gammaproteobacteria J Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_784632_2 1469245.JFBG01000035_gene1999 7.92e-51 174.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1WW4R@135613|Chromatiales 135613|Chromatiales D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves - - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_1150000_1 195522.BD01_1400 1.58e-12 67.8 COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,243AQ@183968|Thermococci 183968|Thermococci C Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn,Intein_splicing,LAGLIDADG_3 k59_680182_1 631454.N177_1724 3.11e-50 167.0 COG2227@1|root,COG2227@2|Bacteria,1N3GZ@1224|Proteobacteria,2UD7N@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_23 k59_209770_1 1125863.JAFN01000001_gene1155 5.24e-51 183.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria 28221|Deltaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1359058_1 105559.Nwat_1289 1.69e-102 322.0 COG1452@1|root,COG1452@2|Bacteria,1QW3G@1224|Proteobacteria,1T2RD@1236|Gammaproteobacteria,1WWPC@135613|Chromatiales 135613|Chromatiales M involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - - - - - - - - - - - k59_262090_1 706587.Desti_4551 8.48e-06 53.9 COG2202@1|root,COG3829@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43D9U@68525|delta/epsilon subdivisions,2WIJG@28221|Deltaproteobacteria 2|Bacteria KT PFAM Bacterial regulatory protein, Fis family - - - ko:K10941 ko02020,ko02025,ko05111,map02020,map02025,map05111 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Sigma54_activat,SpoIIE k59_209775_2 706587.Desti_0087 3.07e-34 128.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,2MQFV@213462|Syntrophobacterales 28221|Deltaproteobacteria U PFAM MotA TolQ ExbB proton channel aglX - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_993293_1 395495.Lcho_1830 5.01e-59 193.0 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2VH10@28216|Betaproteobacteria,1KK20@119065|unclassified Burkholderiales 28216|Betaproteobacteria H GTP cyclohydrolase folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_813_1 685727.REQ_04810 1.34e-52 179.0 2BYTM@1|root,2Z7KC@2|Bacteria,2GJ6K@201174|Actinobacteria,4FU8Z@85025|Nocardiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_105296_2 566461.SSFG_07464 4.32e-125 370.0 COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria 201174|Actinobacteria C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_418790_1 314278.NB231_10858 7.18e-18 77.4 COG0636@1|root,COG0636@2|Bacteria,1R359@1224|Proteobacteria,1T63K@1236|Gammaproteobacteria,1X2WZ@135613|Chromatiales 135613|Chromatiales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_418790_2 472759.Nhal_3952 1.63e-112 332.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1WWUT@135613|Chromatiales 135613|Chromatiales C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_314331_1 1479235.KK366039_gene2319 2.52e-35 138.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1XHB6@135619|Oceanospirillales 135619|Oceanospirillales M transferase waaA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N k59_314331_2 879310.HMPREF9162_1078 8.23e-36 139.0 COG1519@1|root,COG1663@1|root,COG1519@2|Bacteria,COG1663@2|Bacteria,1TT7Z@1239|Firmicutes,4H238@909932|Negativicutes 909932|Negativicutes M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N,LpxK k59_732244_1 1038859.AXAU01000005_gene5229 1.97e-23 94.7 COG2050@1|root,COG2050@2|Bacteria,1RGVD@1224|Proteobacteria,2U9MH@28211|Alphaproteobacteria,3JY97@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_1255832_1 1449976.KALB_1640 1.07e-28 113.0 COG2141@1|root,COG2141@2|Bacteria,2GNQ1@201174|Actinobacteria,4E1GS@85010|Pseudonocardiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_315350_1 1057002.KB905370_gene3483 5.05e-77 252.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria,4B8CP@82115|Rhizobiaceae 28211|Alphaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_471606_1 1120948.KB903226_gene5485 0.000191 46.6 COG0500@1|root,COG0500@2|Bacteria,2HFN5@201174|Actinobacteria,4E7IZ@85010|Pseudonocardiales 201174|Actinobacteria Q Thiopurine S-methyltransferase (TPMT) - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 k59_210812_1 570967.JMLV01000008_gene1335 5.32e-97 292.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TSBB@28211|Alphaproteobacteria,2JR85@204441|Rhodospirillales 204441|Rhodospirillales CE Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.83,1.1.1.93,4.1.1.73 ko:K07246 ko00630,ko00650,map00630,map00650 - R00215,R01751,R02545,R06180 RC00084,RC00105,RC00594 ko00000,ko00001,ko01000 - - - Iso_dh k59_890012_1 1437824.BN940_16146 3.68e-44 157.0 COG0665@1|root,COG0665@2|Bacteria,1MXD1@1224|Proteobacteria,2VKJ5@28216|Betaproteobacteria,3T3CA@506|Alcaligenaceae 28216|Betaproteobacteria E FAD dependent oxidoreductase - - 1.4.99.6 ko:K19746 ko00472,ko01100,map00472,map01100 - R11018 RC00006 ko00000,ko00001,ko01000 - - - DAO k59_54555_1 1229909.NSED_09500 2.58e-16 79.0 COG0668@1|root,arCOG01568@2157|Archaea,41SYX@651137|Thaumarchaeota 651137|Thaumarchaeota M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_54555_2 1229909.NSED_09495 1.32e-25 103.0 COG1509@1|root,arCOG03246@2157|Archaea,41SY6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM lysine 2,3-aminomutase YodO family protein - - - - - - - - - - - - - k59_1411907_1 211165.AJLN01000143_gene1406 1.26e-89 276.0 COG1763@1|root,COG1763@2|Bacteria,1G6XG@1117|Cyanobacteria,1JK9W@1189|Stigonemataceae 1117|Cyanobacteria H Mo-molybdopterin cofactor biosynthetic process - - - - - - - - - - - - - k59_785807_2 1121385.AQXW01000004_gene1070 1.21e-12 68.2 COG0461@1|root,COG1611@1|root,COG0461@2|Bacteria,COG1611@2|Bacteria,2HK5Y@201174|Actinobacteria,1ZX3N@145357|Dermacoccaceae 201174|Actinobacteria F Belongs to the LOG family - - - - - - - - - - - - - k59_471617_1 864069.MicloDRAFT_00013770 4.13e-57 191.0 COG0477@1|root,COG2814@2|Bacteria,1MWFH@1224|Proteobacteria,2TR0R@28211|Alphaproteobacteria,1JX0W@119045|Methylobacteriaceae 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_106038_1 1229909.NSED_09675 2.55e-101 307.0 COG1252@1|root,arCOG01067@2157|Archaea 2157|Archaea C COG1252 NADH dehydrogenase, FAD-containing subunit ndh2 - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_106038_2 1459636.NTE_02476 1.75e-63 202.0 COG2086@1|root,arCOG00446@2157|Archaea,41SX2@651137|Thaumarchaeota 651137|Thaumarchaeota C Electron transfer flavoprotein domain - - - ko:K03521 - - - - ko00000 - - - ETF k59_785812_1 518766.Rmar_2551 9.68e-59 194.0 COG0714@1|root,COG0714@2|Bacteria,4NDVZ@976|Bacteroidetes,1FITR@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S ATPase family associated with various cellular activities (AAA) moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_785818_1 379066.GAU_1063 2.24e-06 56.2 COG0534@1|root,COG0534@2|Bacteria,1ZT8D@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MatE - - - - - - - - - - - - MatE k59_844624_1 83406.HDN1F_05290 1.03e-43 161.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1J5I7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0405 Gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_844624_2 234831.PSM_A0804 2.4e-63 199.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,2Q23Z@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO0053,iSDY_1059.SDY_4064 CTP_transf_like k59_844627_1 1127673.GLIP_0055 1.46e-111 328.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,464YS@72275|Alteromonadaceae 1236|Gammaproteobacteria H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0030145,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2436,iBWG_1329.BWG_2198,iECDH10B_1368.ECDH10B_2601,iECDH1ME8569_1439.ECDH1ME8569_2370,iETEC_1333.ETEC_2549,iEcDH1_1363.EcDH1_1225,iEcHS_1320.EcHS_A2573,iEcolC_1368.EcolC_1243,iJO1366.b2436,iJR904.b2436,iY75_1357.Y75_RS12760 Coprogen_oxidas k59_112594_1 1265313.HRUBRA_02651 2.46e-89 276.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,1RZHC@1236|Gammaproteobacteria 1236|Gammaproteobacteria C acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1520769_2 935261.JAGL01000022_gene192 1.27e-24 97.1 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,43J12@69277|Phyllobacteriaceae 28211|Alphaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_4287_1 298386.PBPRB0296 2.48e-18 79.0 COG2929@1|root,COG2929@2|Bacteria,1N6QP@1224|Proteobacteria,1SESI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - ko:K09803 - - - - ko00000 - - - BrnT_toxin k59_4287_2 1123228.AUIH01000111_gene3771 6.09e-24 92.4 COG3514@1|root,COG3514@2|Bacteria,1NAV1@1224|Proteobacteria,1SC0H@1236|Gammaproteobacteria,1XPJW@135619|Oceanospirillales 135619|Oceanospirillales S BrnA antitoxin of type II toxin-antitoxin system - - - - - - - - - - - - BrnA_antitoxin k59_374587_1 1177154.Y5S_00553 3.27e-67 216.0 COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,1SKHE@1236|Gammaproteobacteria 1236|Gammaproteobacteria V ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane_3 k59_948461_1 861299.J421_3552 2.23e-19 86.3 COG0810@1|root,COG0810@2|Bacteria,1ZTWX@142182|Gemmatimonadetes 142182|Gemmatimonadetes M TonB C terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_2 k59_1105993_1 1379270.AUXF01000001_gene2272 1.22e-34 139.0 COG1524@1|root,COG1524@2|Bacteria,1ZUMA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_794842_1 1042209.HK44_006870 5.09e-10 58.9 COG1024@1|root,COG1024@2|Bacteria,1PSRK@1224|Proteobacteria,1RZ2F@1236|Gammaproteobacteria 1236|Gammaproteobacteria I enoyl-CoA hydratase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_794842_2 1301098.PKB_4260 1.13e-81 253.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,1RPW2@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG1960 Acyl-CoA dehydrogenases - - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_897041_1 1174684.EBMC1_05754 5.2e-17 83.2 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TTRR@28211|Alphaproteobacteria,2K5DY@204457|Sphingomonadales 204457|Sphingomonadales Q Cytochrome P450 - - 1.14.13.151 ko:K05525 ko00902,ko01110,map00902,map01110 - R04366,R09922,R09923,R09924,R09925 RC01137,RC02561,RC02626 ko00000,ko00001,ko00199,ko01000 - - - p450 k59_897041_2 269799.Gmet_1239 4.15e-07 51.6 COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,42M13@68525|delta/epsilon subdivisions,2WQAC@28221|Deltaproteobacteria,43T6M@69541|Desulfuromonadales 28221|Deltaproteobacteria S Protein of unknown function (DUF815) - - - ko:K06923 - - - - ko00000 - - - DUF815 k59_1419178_1 338969.Rfer_4197 1.97e-20 90.1 COG0009@1|root,COG0009@2|Bacteria,1RFY0@1224|Proteobacteria 1224|Proteobacteria J Telomere recombination - - - - - - - - - - - - Sua5_yciO_yrdC k59_689722_2 330214.NIDE0485 3.19e-79 246.0 COG0137@1|root,COG0137@2|Bacteria,3J0BU@40117|Nitrospirae 40117|Nitrospirae E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_530991_1 436308.Nmar_1490 2.82e-122 356.0 COG0180@1|root,arCOG01887@2157|Archaea,41SDK@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family - - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_1053680_1 1191523.MROS_2026 8.38e-55 193.0 COG0574@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0784@2|Bacteria 2|Bacteria T Response regulator, receiver - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PPDK_N,Response_reg,SpoIIE k59_63522_2 397278.JOJN01000031_gene3082 6.32e-23 90.9 COG2801@1|root,COG2801@2|Bacteria,2GKW1@201174|Actinobacteria,4DQK4@85009|Propionibacteriales 201174|Actinobacteria L Integrase core domain - - - - - - - - - - - - HTH_21,rve,rve_3 k59_739923_1 1095769.CAHF01000006_gene1763 2.45e-86 266.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2VIJB@28216|Betaproteobacteria,4724J@75682|Oxalobacteraceae 28216|Betaproteobacteria C Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily - - 1.1.1.1,1.1.1.284 ko:K00001,ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1520788_1 436308.Nmar_1396 1.12e-75 234.0 COG1522@1|root,arCOG04153@2157|Archaea,41SP6@651137|Thaumarchaeota 651137|Thaumarchaeota K COG1522 Transcriptional regulators - - - - - - - - - - - - - k59_1106017_1 102232.GLO73106DRAFT_00007690 1.68e-30 124.0 COG0745@1|root,COG3852@1|root,COG5001@1|root,COG0745@2|Bacteria,COG3852@2|Bacteria,COG5001@2|Bacteria,1G0BS@1117|Cyanobacteria 1117|Cyanobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1212705_2 631362.Thi970DRAFT_04217 2.62e-50 167.0 COG2230@1|root,COG2230@2|Bacteria,1QVX6@1224|Proteobacteria,1T2MM@1236|Gammaproteobacteria,1X2UB@135613|Chromatiales 135613|Chromatiales M Protein of unknown function (DUF938) - - - - - - - - - - - - DUF938 k59_1106018_1 754476.Q7A_2923 2.14e-63 206.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,45ZWY@72273|Thiotrichales 72273|Thiotrichales Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_1520791_1 436308.Nmar_0493 1.97e-14 70.9 COG1587@1|root,arCOG02048@2157|Archaea,41SN2@651137|Thaumarchaeota 651137|Thaumarchaeota H Uroporphyrinogen-III synthase HemD - - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 k59_1520791_2 436308.Nmar_0495 4.77e-64 207.0 COG0719@1|root,arCOG01715@2157|Archaea,41S5W@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly protein SufB - - - ko:K09014 - - - - ko00000 - - - UPF0051 k59_1000638_1 269799.Gmet_1458 2.06e-22 105.0 COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,42TFA@68525|delta/epsilon subdivisions,2WQ54@28221|Deltaproteobacteria 28221|Deltaproteobacteria U TIGRFAM filamentous haemagglutinin family outer membrane protein - - - - - - - - - - - - DUF3739,Haemagg_act k59_1419220_1 395493.BegalDRAFT_0737 1.25e-138 406.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,46000@72273|Thiotrichales 72273|Thiotrichales P TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_531018_1 485915.Dret_1954 5.8e-74 231.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,42N17@68525|delta/epsilon subdivisions,2WJE8@28221|Deltaproteobacteria,2M85A@213115|Desulfovibrionales 28221|Deltaproteobacteria H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_583260_2 196490.AUEZ01000041_gene5977 1.64e-05 49.3 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TS6G@28211|Alphaproteobacteria,3JUD7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Dehydrogenase MA20_16310 - - - - - - - - - - - adh_short,adh_short_C2 k59_4304_1 105559.Nwat_2763 5.78e-78 244.0 COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,1RNKP@1236|Gammaproteobacteria 1236|Gammaproteobacteria O PFAM peptidase - - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_1367028_1 314264.ROS217_07380 5.9e-51 169.0 COG0765@1|root,COG0765@2|Bacteria,1MUVX@1224|Proteobacteria,2TRAT@28211|Alphaproteobacteria,46PTR@74030|Roseovarius 28211|Alphaproteobacteria P COG0765 ABC-type amino acid transport system, permease component gltJ - - ko:K10003 ko02010,ko02020,map02010,map02020 M00230 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.19,3.A.1.3.4 - - BPD_transp_1 k59_270164_1 509191.AEDB02000040_gene4573 1.99e-192 544.0 COG1896@1|root,COG1896@2|Bacteria,1U0JV@1239|Firmicutes,24CJX@186801|Clostridia 186801|Clostridia S HD domain - - - ko:K07023 - - - - ko00000 - - - HD_3 k59_1628309_1 378806.STAUR_0531 1.72e-153 459.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42Z54@68525|delta/epsilon subdivisions,2WUB9@28221|Deltaproteobacteria,2YYC4@29|Myxococcales 28221|Deltaproteobacteria J Anticodon-binding domain of tRNA valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_1264854_2 1229909.NSED_08765 1.15e-34 126.0 COG0640@1|root,arCOG03067@2157|Archaea 2157|Archaea K transcriptional regulators - - - - - - - - - - - - HTH_20 k59_897090_1 1192034.CAP_5040 7.4e-68 224.0 COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1MXA1@1224|Proteobacteria,42PXZ@68525|delta/epsilon subdivisions,2X667@28221|Deltaproteobacteria,2Z33M@29|Myxococcales 28221|Deltaproteobacteria P Substrate binding domain of ABC-type glycine betaine transport system - - - ko:K05845,ko:K05846 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1,OpuAC k59_948513_2 1122604.JONR01000019_gene1162 9.24e-08 57.8 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,1X5V0@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16 k59_690205_1 697282.Mettu_1776 4.42e-39 144.0 COG1216@1|root,COG1216@2|Bacteria,1QTEK@1224|Proteobacteria,1S5EC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Pfam Glycosyl transferase family 2 - - - ko:K12990 ko02024,ko02025,map02024,map02025 - - - ko00000,ko00001,ko01000,ko01003,ko01005 - GT2 - Glycos_transf_2 k59_845125_1 1177181.T9A_02964 2.46e-40 154.0 COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,1RZ5Y@1236|Gammaproteobacteria,1XJEQ@135619|Oceanospirillales 135619|Oceanospirillales S COG3552 Protein containing von Willebrand factor type A (vWA) domain - - - ko:K07161 - - - - ko00000 - - - VWA_CoxE k59_270606_1 330214.NIDE2515 5.44e-47 171.0 COG2982@1|root,COG2982@2|Bacteria 2|Bacteria M Protein involved in outer membrane biogenesis - - - ko:K07290 - - - - ko00000 9.B.121 - - AsmA,AsmA_2,DUF3971,DUF748 k59_638665_1 1487923.DP73_17175 4.4e-66 222.0 COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24BRX@186801|Clostridia,260H8@186807|Peptococcaceae 186801|Clostridia H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_113093_1 330214.NIDE0539 3.36e-74 245.0 COG1674@1|root,COG1674@2|Bacteria,3J0BQ@40117|Nitrospirae 40117|Nitrospirae D Ftsk_gamma ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1158067_1 1123368.AUIS01000003_gene1680 3.25e-82 251.0 COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,1RMTR@1236|Gammaproteobacteria,2NBYJ@225057|Acidithiobacillales 225057|Acidithiobacillales H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis - - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_740397_1 159087.Daro_0931 5.18e-51 174.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2VIV0@28216|Betaproteobacteria,2KV3J@206389|Rhodocyclales 206389|Rhodocyclales F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP ppnK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_1575850_1 649638.Trad_0892 1.23e-43 157.0 COG1524@1|root,COG1524@2|Bacteria,1WMAB@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_1473463_1 1283287.KB822578_gene2536 8.28e-07 52.0 COG4221@1|root,COG4221@2|Bacteria,2GN3I@201174|Actinobacteria,4DWG1@85009|Propionibacteriales 201174|Actinobacteria S KR domain - - - - - - - - - - - - adh_short k59_1473463_2 861208.AGROH133_07742 8.11e-22 89.0 COG3952@1|root,COG3952@2|Bacteria,1MZ60@1224|Proteobacteria,2UCCY@28211|Alphaproteobacteria,4BK0T@82115|Rhizobiaceae 28211|Alphaproteobacteria S Lipid A Biosynthesis N-terminal domain - - - - - - - - - - - - LAB_N k59_1473463_3 314345.SPV1_14239 2.25e-08 55.1 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria 1224|Proteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_795540_1 1392540.P256_02498 8.83e-06 46.2 COG0625@1|root,COG0625@2|Bacteria,1RA4M@1224|Proteobacteria,1RYD2@1236|Gammaproteobacteria,3NIJH@468|Moraxellaceae 1236|Gammaproteobacteria O Glutathione S-transferase, N-terminal domain yliJ - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_C_3,GST_N,GST_N_3 k59_795540_2 1380394.JADL01000001_gene3074 9.9e-35 124.0 COG3686@1|root,COG3686@2|Bacteria,1RAEH@1224|Proteobacteria,2U5JJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S MAPEG family MA20_30600 - - - - - - - - - - - MAPEG k59_375171_1 1120999.JONM01000005_gene3836 4.12e-24 107.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,2KQ5Z@206351|Neisseriales 206351|Neisseriales H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_531513_1 1196028.ALEF01000042_gene739 7.02e-09 58.9 COG0665@1|root,COG0665@2|Bacteria,1VTRW@1239|Firmicutes,4HBBK@91061|Bacilli,4C5NW@84406|Virgibacillus 91061|Bacilli E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_531513_2 391624.OIHEL45_17941 4.22e-11 65.1 COG1999@1|root,COG1999@2|Bacteria,1N6WC@1224|Proteobacteria,2U24Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria S protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_583748_2 911239.CF149_18826 1.62e-46 157.0 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria 1236|Gammaproteobacteria C cytochrome cc4 - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_531515_1 1236973.JCM9157_3763 5.88e-43 154.0 COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,4H9V5@91061|Bacilli,1ZAVH@1386|Bacillus 91061|Bacilli M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU GO:0000270,GO:0000271,GO:0003674,GO:0003824,GO:0003977,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0030203,GO:0033692,GO:0034637,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3,NTP_transferase k59_531515_2 992406.RIA_0543 3.9e-08 54.3 COG0449@1|root,COG0449@2|Bacteria,4NE8Q@976|Bacteroidetes,1HX0U@117743|Flavobacteriia 976|Bacteroidetes M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_845155_1 436308.Nmar_0253 3.95e-94 281.0 COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota 651137|Thaumarchaeota C oxidoreductase FAD NAD(P)-binding - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_427276_1 396588.Tgr7_1759 6.68e-110 335.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1WW4U@135613|Chromatiales 135613|Chromatiales L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1054198_1 335543.Sfum_3649 4.96e-133 397.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2WIZQ@28221|Deltaproteobacteria,2MQZI@213462|Syntrophobacterales 28221|Deltaproteobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_427282_1 984962.XP_009545196.1 1.81e-57 198.0 COG1048@1|root,KOG0453@2759|Eukaryota,38FZD@33154|Opisthokonta,3NUC6@4751|Fungi,3UXT3@5204|Basidiomycota,22655@155619|Agaricomycetes,3H1WM@355688|Agaricomycetes incertae sedis 4751|Fungi E Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis LYS4 GO:0003674,GO:0003824,GO:0004409,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006536,GO:0006553,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009066,GO:0009067,GO:0009085,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019725,GO:0019752,GO:0019878,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0098771,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.36 ko:K01705 ko00300,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map01100,map01120,map01130,map01210,map01230 M00030,M00433 R04371 RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_375186_1 1380394.JADL01000001_gene2034 7.78e-91 293.0 COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,2TRSY@28211|Alphaproteobacteria,2JPPS@204441|Rhodospirillales 204441|Rhodospirillales V ABC transporter transmembrane region - - - ko:K02021 - - - - ko00000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran,cNMP_binding k59_583763_1 247156.NFA_33520 1.49e-49 172.0 COG2141@1|root,COG2141@2|Bacteria,2IJQ4@201174|Actinobacteria,4G8WQ@85025|Nocardiaceae 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_583763_2 340177.Cag_0798 7.73e-20 89.7 COG0436@1|root,COG0436@2|Bacteria,1FD92@1090|Chlorobi 1090|Chlorobi H aminotransferase class I and II - - - ko:K10907 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_531527_1 690850.Desaf_2369 3.31e-50 174.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42MAI@68525|delta/epsilon subdivisions,2WJ8M@28221|Deltaproteobacteria,2M84R@213115|Desulfovibrionales 28221|Deltaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_64191_1 1254432.SCE1572_29360 1.26e-180 523.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WUHZ@28221|Deltaproteobacteria,2YX7U@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_531531_1 330214.NIDE1729 3.83e-55 180.0 COG0576@1|root,COG0576@2|Bacteria,3J0QP@40117|Nitrospirae 40117|Nitrospirae O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_113146_1 909663.KI867150_gene2500 1.26e-65 212.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,2MQSW@213462|Syntrophobacterales 28221|Deltaproteobacteria F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_690265_1 85643.Tmz1t_0807 1.36e-72 239.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,2KU6T@206389|Rhodocyclales 206389|Rhodocyclales I 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_747563_1 1453501.JELR01000001_gene2105 1.46e-85 266.0 COG1228@1|root,COG1228@2|Bacteria,1MXXR@1224|Proteobacteria,1RRK7@1236|Gammaproteobacteria,46458@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 k59_1374589_1 59538.XP_005981185.1 3.13e-46 166.0 2CMC3@1|root,2QPXZ@2759|Eukaryota,38CYT@33154|Opisthokonta 33154|Opisthokonta G feruloyl esterase activity faeB-1 GO:0000272,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010383,GO:0010393,GO:0010410,GO:0016052,GO:0016787,GO:0016788,GO:0016998,GO:0017144,GO:0030600,GO:0042737,GO:0042802,GO:0042803,GO:0043170,GO:0044036,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0045488,GO:0045490,GO:0045491,GO:0045493,GO:0046983,GO:0052689,GO:0071554,GO:0071704,GO:1901575 3.1.1.73 ko:K09252 - - - - ko00000,ko01000 - - - Tannase k59_697472_1 445686.E3SLA6_9CAUD 1.54e-88 268.0 4QASV@10239|Viruses,4QWD9@35237|dsDNA viruses no RNA stage,4QQ4N@28883|Caudovirales,4QIBN@10662|Myoviridae 10662|Myoviridae S recA bacterial DNA recombination protein - - - - - - - - - - - - - k59_121786_1 765910.MARPU_04560 3.15e-125 388.0 COG0834@1|root,COG1301@1|root,COG0834@2|Bacteria,COG1301@2|Bacteria,1P22C@1224|Proteobacteria,1RSGY@1236|Gammaproteobacteria,1WZZV@135613|Chromatiales 135613|Chromatiales U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SBP_bac_3,SDF k59_121786_2 240016.ABIZ01000001_gene965 2.41e-33 126.0 COG0760@1|root,COG0760@2|Bacteria,46VUP@74201|Verrucomicrobia,2IVK4@203494|Verrucomicrobiae 203494|Verrucomicrobiae O PPIC-type PPIASE domain - - - - - - - - - - - - Rotamase_2 k59_330668_1 998088.B565_2708 5.81e-42 141.0 COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,1S8TR@1236|Gammaproteobacteria,1Y4U9@135624|Aeromonadales 135624|Aeromonadales P Belongs to the ArsC family - - - - - - - - - - - - ArsC k59_330668_2 1269813.ATUL01000014_gene1460 4.46e-13 67.4 COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,1RPCS@1236|Gammaproteobacteria,1WVX8@135613|Chromatiales 135613|Chromatiales E Belongs to the transferase hexapeptide repeat family dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,THDPS_N_2 k59_1374598_1 1265503.KB905161_gene3198 4.86e-36 132.0 COG0454@1|root,COG0456@2|Bacteria,1R407@1224|Proteobacteria,1RPJ2@1236|Gammaproteobacteria,2Q5NJ@267889|Colwelliaceae 1236|Gammaproteobacteria K Putative thioesterase (yiiD_Cterm) yiiD GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,YiiD_C k59_434739_1 1279015.KB908462_gene1885 1.11e-46 167.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E glutamine synthetase - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_1220776_1 1123288.SOV_6c02510 2.36e-31 128.0 COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4H2AI@909932|Negativicutes 909932|Negativicutes EGP Major Facilitator - - - - - - - - - - - - MFS_1,Sugar_tr k59_1220776_3 1121878.AUGL01000009_gene3375 1.24e-05 48.1 COG1028@1|root,COG3173@1|root,COG1028@2|Bacteria,COG3173@2|Bacteria,1MWGC@1224|Proteobacteria,1RRE1@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) HA62_15005 - - - - - - - - - - - adh_short_C2 k59_1061810_1 1123073.KB899241_gene2265 6.67e-75 236.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,1X4F0@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_434745_1 1038859.AXAU01000028_gene21 3.82e-201 567.0 COG0683@1|root,COG0683@2|Bacteria,1MWNB@1224|Proteobacteria,2TTAH@28211|Alphaproteobacteria,3JZY2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Periplasmic binding protein domain - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_7657_1 243090.RB11084 1.17e-09 60.5 COG0457@1|root,COG0795@1|root,COG0457@2|Bacteria,COG0795@2|Bacteria,2IXP3@203682|Planctomycetes 203682|Planctomycetes C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554,TPR_16 k59_384008_1 399739.Pmen_3962 1.15e-14 83.6 COG0576@1|root,COG5283@1|root,COG0576@2|Bacteria,COG5283@2|Bacteria,1R018@1224|Proteobacteria 1224|Proteobacteria O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ - - - - - - - - - - - - - k59_648266_1 1192034.CAP_6174 3.94e-71 238.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2YX2C@29|Myxococcales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1429324_1 396588.Tgr7_2953 8.85e-60 200.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1WX0Q@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_1222242_2 1343740.M271_23605 1.58e-05 45.8 COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - 1.1.1.53 ko:K00038 ko00140,ko01100,map00140,map01100 - R04831,R04834,R04844,R04847 RC00139,RC01219,RC01220 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_1063058_1 244582.JQAK01000022_gene652 1.96e-16 78.6 2DNPH@1|root,32YF1@2|Bacteria,1NARM@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_279423_1 519989.ECTPHS_00230 1.46e-90 271.0 COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria 1236|Gammaproteobacteria F COG0209 Ribonucleotide reductase, alpha subunit nrdJb - - - - - - - - - - - - k59_1164999_1 305700.B447_19409 2.51e-57 192.0 COG0446@1|root,COG0446@2|Bacteria,1QXK6@1224|Proteobacteria 1224|Proteobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_1010000_1 1532557.JL37_22520 1.73e-41 151.0 COG2271@1|root,COG2271@2|Bacteria,1MUEK@1224|Proteobacteria,2VHF2@28216|Betaproteobacteria,3T3BG@506|Alcaligenaceae 28216|Betaproteobacteria G MFS transporter - - - - - - - - - - - - MFS_1 k59_1063062_1 400682.PAC_15709637 2.1e-75 248.0 COG0060@1|root,KOG0434@2759|Eukaryota,38CIS@33154|Opisthokonta,3BA51@33208|Metazoa 33208|Metazoa J isoleucyl-tRNA aminoacylation Aats-ile GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,RRM_1,tRNA-synt_1 k59_906140_1 1232410.KI421421_gene3631 2.66e-177 508.0 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,42MNS@68525|delta/epsilon subdivisions,2WSQX@28221|Deltaproteobacteria 28221|Deltaproteobacteria C ATP ADP translocase - - - ko:K03301 - - - - ko00000 2.A.12 - - MFS_1,TLC k59_436233_1 1297570.MESS4_750068 2.21e-117 348.0 COG2041@1|root,COG2041@2|Bacteria,1NR5V@1224|Proteobacteria,2UQ6F@28211|Alphaproteobacteria,43R8Z@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Oxidoreductase molybdopterin binding domain - - - - - - - - - - - - Mo-co_dimer,Oxidored_molyb k59_748856_1 290397.Adeh_0622 9.38e-83 261.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2YTYC@29|Myxococcales 28221|Deltaproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N,cNMP_binding k59_539773_1 1286171.EAL2_808p05570 1.59e-07 54.3 arCOG06631@1|root,32RY6@2|Bacteria,1V8RP@1239|Firmicutes,24MV5@186801|Clostridia,25XHE@186806|Eubacteriaceae 186801|Clostridia S EamA-like transporter family - - - - - - - - - - - - EamA k59_226704_1 330214.NIDE3309 5.86e-45 162.0 COG1413@1|root,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity - - - - - - - - - - - - HEAT,HEAT_2,HEAT_PBS k59_1276798_1 1121033.AUCF01000009_gene1086 1.3e-125 372.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria,2JPVB@204441|Rhodospirillales 204441|Rhodospirillales M Belongs to the UDP-glucose GDP-mannose dehydrogenase family rkpK - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1063083_1 316057.RPD_0744 1.04e-25 103.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,3JURJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_1063083_2 1280947.HY30_19125 8.79e-21 89.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,43ZYS@69657|Hyphomonadaceae 28211|Alphaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_957405_1 756067.MicvaDRAFT_4447 0.000389 48.1 COG0642@1|root,COG2205@2|Bacteria,1G4YD@1117|Cyanobacteria,1HAET@1150|Oscillatoriales 1117|Cyanobacteria T Signal Transduction Histidine Kinase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS k59_1222289_2 756272.Plabr_4411 4.5e-34 130.0 COG0331@1|root,COG0331@2|Bacteria,2IYY1@203682|Planctomycetes 203682|Planctomycetes I [acyl-carrier-protein] S-malonyltransferase activity - - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - - k59_172082_1 876044.IMCC3088_2834 1.43e-67 221.0 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA GO:0003674,GO:0003824,GO:0004357,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0010038,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042221,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046685,GO:0046689,GO:0046872,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0070887,GO:0071241,GO:0071243,GO:0071248,GO:0071288,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_2885 Glu_cys_ligase k59_123409_1 573064.Mefer_0899 9.79e-38 135.0 COG2085@1|root,arCOG00457@2157|Archaea,2XUD2@28890|Euryarchaeota,23QAN@183939|Methanococci 183939|Methanococci C PFAM NADP oxidoreductase coenzyme F420-dependent - GO:0000041,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006826,GO:0008150,GO:0008152,GO:0008823,GO:0015677,GO:0015682,GO:0016020,GO:0016021,GO:0016491,GO:0016722,GO:0016723,GO:0030001,GO:0031224,GO:0031226,GO:0033216,GO:0034220,GO:0034755,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0052851,GO:0055085,GO:0055114,GO:0071944,GO:0072512,GO:0097286,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098706,GO:0098711,GO:0098739,GO:0099587 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored k59_331919_1 1158345.JNLL01000001_gene1830 9.49e-10 62.4 COG0525@1|root,COG0525@2|Bacteria,2G3V5@200783|Aquificae 200783|Aquificae J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_539796_1 1303692.SFUL_4330 8.63e-23 100.0 COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_1484591_1 754476.Q7A_2083 6.1e-25 107.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,45ZSE@72273|Thiotrichales 72273|Thiotrichales C dihydrolipoamide dehydrogenase - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_385701_1 396588.Tgr7_1124 1.87e-131 381.0 28I2K@1|root,2Z86N@2|Bacteria,1R1GA@1224|Proteobacteria,1RRPU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1063107_1 319795.Dgeo_1304 5.6e-29 115.0 COG0166@1|root,COG0166@2|Bacteria,1WIGN@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_1063107_2 1440774.Y900_018125 7.1e-56 185.0 COG3804@1|root,COG3804@2|Bacteria,2GMU5@201174|Actinobacteria,2341J@1762|Mycobacteriaceae 201174|Actinobacteria S dihydrodipicolinate reductase - - 1.4.1.12,1.4.1.26 ko:K21672 ko00310,ko00330,ko00472,map00310,map00330,map00472 - R02825,R04200,R04201,R04687,R04688 RC00249,RC00790 ko00000,ko00001,ko01000 - - - DapB_N k59_1010058_1 330214.NIDE3821 1.99e-19 86.3 COG0836@1|root,COG0836@2|Bacteria 2|Bacteria M mannose-1-phosphate guanylyltransferase activity manC - 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_436297_1 637389.Acaty_c2394 7.46e-16 77.4 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,2NCKR@225057|Acidithiobacillales 225057|Acidithiobacillales C Proton-conducting membrane transporter - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_436297_2 396588.Tgr7_0999 4.04e-159 462.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1WW6G@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1063116_1 243274.THEMA_05400 1.02e-24 99.0 COG0781@1|root,COG0781@2|Bacteria,2GDBQ@200918|Thermotogae 200918|Thermotogae K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_1063116_2 1217710.F969_01645 5.67e-20 90.1 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,3NIQH@468|Moraxellaceae 1236|Gammaproteobacteria E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0421 Glycos_trans_3N,Glycos_transf_3 k59_1484612_1 448385.sce0567 2.36e-33 132.0 COG3973@1|root,COG3973@2|Bacteria,1P638@1224|Proteobacteria,42MXR@68525|delta/epsilon subdivisions,2WK1Z@28221|Deltaproteobacteria,2Z32G@29|Myxococcales 28221|Deltaproteobacteria L DNA helicase - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_19,UvrD_C_2 k59_1484614_1 395493.BegalDRAFT_3120 2.15e-59 207.0 COG2176@1|root,COG5000@1|root,COG2176@2|Bacteria,COG5000@2|Bacteria,1QUVW@1224|Proteobacteria,1RV0N@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase III - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - PAS_4,PAS_9,RNase_T k59_75256_1 1131553.JIBI01000002_gene1804 4.07e-55 187.0 COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2VJEQ@28216|Betaproteobacteria,372MX@32003|Nitrosomonadales 28216|Betaproteobacteria G BT1 family - - - - - - - - - - - - BT1 k59_957445_2 1266925.JHVX01000004_gene1267 2.39e-36 137.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2VHE8@28216|Betaproteobacteria,372I7@32003|Nitrosomonadales 28216|Betaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_385744_1 93220.LV28_00530 1.06e-83 274.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,1K43X@119060|Burkholderiaceae 28216|Betaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N,IF2_assoc k59_279499_2 296591.Bpro_4334 5.15e-38 138.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,4ABVU@80864|Comamonadaceae 28216|Betaproteobacteria L Integrase, catalytic region - - - - - - - - - - - - HTH_38,rve k59_807018_1 391625.PPSIR1_01557 1.75e-104 308.0 COG4312@1|root,COG4312@2|Bacteria,1NAXN@1224|Proteobacteria,432M0@68525|delta/epsilon subdivisions,2WYGD@28221|Deltaproteobacteria,2YW8Y@29|Myxococcales 28221|Deltaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF899 k59_1584608_1 1485545.JQLW01000011_gene1385 4.45e-21 102.0 COG2885@1|root,COG2885@2|Bacteria,1N97C@1224|Proteobacteria 1224|Proteobacteria M Belongs to the ompA family - - - - - - - - - - - - DUF4398,DUF937,OmpA k59_1010078_1 981085.XP_010105317.1 5.86e-28 110.0 COG0604@1|root,KOG1197@2759|Eukaryota,37J2B@33090|Viridiplantae,3G7P5@35493|Streptophyta,4JD8C@91835|fabids 35493|Streptophyta C quinone oxidoreductase - GO:0000902,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003960,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009653,GO:0009664,GO:0009826,GO:0009827,GO:0009828,GO:0009987,GO:0016020,GO:0016043,GO:0016049,GO:0016491,GO:0016651,GO:0016655,GO:0017091,GO:0030312,GO:0032502,GO:0032989,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042545,GO:0044424,GO:0044444,GO:0044464,GO:0045229,GO:0048589,GO:0048856,GO:0048869,GO:0050896,GO:0051716,GO:0055114,GO:0060560,GO:0070887,GO:0071554,GO:0071555,GO:0071669,GO:0071840,GO:0071944,GO:0097159,GO:1901363 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_1010078_2 316067.Geob_0240 6.07e-121 369.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria 28221|Deltaproteobacteria C malic protein domain protein maeB - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1637 Malic_M,PTA_PTB,malic k59_1276885_1 105559.Nwat_0309 5.19e-44 149.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1WX3P@135613|Chromatiales 135613|Chromatiales E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG k59_1063141_1 395493.BegalDRAFT_0212 9.6e-140 407.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,460AT@72273|Thiotrichales 72273|Thiotrichales C Belongs to the heme-copper respiratory oxidase family - - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_1115044_1 1469245.JFBG01000072_gene78 3.77e-106 332.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1222360_1 105559.Nwat_1612 3.46e-98 313.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1WXAA@135613|Chromatiales 135613|Chromatiales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_1584618_1 1123261.AXDW01000001_gene1339 6.25e-05 45.1 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1X6TJ@135614|Xanthomonadales 135614|Xanthomonadales I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) - - 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - - PgpA k59_1010084_2 626887.J057_02130 6.24e-97 301.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria,4648E@72275|Alteromonadaceae 1236|Gammaproteobacteria Q multicopper oxidases copA2 - - - - - - - - - - - CopB,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_123488_2 1410632.JHWW01000002_gene2340 1.66e-16 82.8 COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,24BJ8@186801|Clostridia,27IRK@186928|unclassified Lachnospiraceae 186801|Clostridia KLT Protein tyrosine kinase - - - - - - - - - - - - PASTA,Pkinase k59_649947_1 1123388.AQWU01000039_gene1601 4.63e-56 192.0 COG0297@1|root,COG0297@2|Bacteria,1WIW3@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_trans_1_4,Glyco_transf_5,Glycos_transf_1 k59_592407_1 999547.KI421500_gene3063 1.93e-64 217.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,28108@191028|Leisingera 28211|Alphaproteobacteria P haloacid dehalogenase-like hydrolase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_539860_1 926560.KE387027_gene862 4.75e-19 84.7 COG1899@1|root,COG1899@2|Bacteria,1WI9Q@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O Deoxyhypusine synthase - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS k59_539860_2 1233951.IO90_14910 2.05e-36 134.0 COG2957@1|root,COG2957@2|Bacteria,4NGF8@976|Bacteroidetes,1HYT2@117743|Flavobacteriia,3HHEQ@358033|Chryseobacterium 976|Bacteroidetes E Belongs to the agmatine deiminase family aguA - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph k59_87049_2 262316.MAP_0671 0.000273 46.2 COG0500@1|root,COG2226@2|Bacteria,2GK7A@201174|Actinobacteria,237ZQ@1762|Mycobacteriaceae 201174|Actinobacteria Q Methionine biosynthesis protein MetW - - - - - - - - - - - - Methyltransf_11,Methyltransf_31 k59_1442550_1 485915.Dret_2002 4.41e-69 221.0 COG3464@1|root,COG3464@2|Bacteria,1R4DH@1224|Proteobacteria,43AQ4@68525|delta/epsilon subdivisions,2X63W@28221|Deltaproteobacteria,2MGXP@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM transposase IS204 IS1001 IS1096 IS1165 family protein - - - - - - - - - - - - DDE_Tnp_ISL3,zf-ISL3 k59_757717_1 748247.AZKH_4447 1.58e-20 94.4 COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHMW@28216|Betaproteobacteria,2KUA5@206389|Rhodocyclales 206389|Rhodocyclales KLT serine threonine protein kinase - - - - - - - - - - - - Pkinase k59_601357_1 436308.Nmar_0282 6.89e-40 136.0 COG0839@1|root,arCOG04654@2157|Archaea,41SM8@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6 - - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_601357_2 1229909.NSED_01305 6.94e-81 241.0 COG1143@1|root,arCOG01543@2157|Archaea,41SGW@651137|Thaumarchaeota 651137|Thaumarchaeota C 4Fe-4S binding domain - - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4,Fer4_4 k59_87057_1 221288.JH992901_gene3895 1.18e-74 236.0 COG0715@1|root,COG0715@2|Bacteria,1GFIM@1117|Cyanobacteria 1117|Cyanobacteria P Protein of unknown function (DUF3500) - - - - - - - - - - - - DUF3500 k59_1383987_1 1123519.PSJM300_15980 2.77e-70 222.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_548429_4 444878.E3SQZ6_9CAUD 3.51e-43 142.0 4QH36@10239|Viruses,4QYHH@35237|dsDNA viruses no RNA stage,4QQFW@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_235484_1 589865.DaAHT2_2063 1.6e-62 204.0 COG0524@1|root,COG0524@2|Bacteria,1QMIR@1224|Proteobacteria,42NDK@68525|delta/epsilon subdivisions,2WK15@28221|Deltaproteobacteria 28221|Deltaproteobacteria G PFAM PfkB domain protein - - 2.7.1.20 ko:K00856 ko00230,ko01100,map00230,map01100 - R00185 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_966266_1 192952.MM_1452 1.59e-08 60.5 COG0589@1|root,arCOG00449@2157|Archaea,2Y8D8@28890|Euryarchaeota 28890|Euryarchaeota T Universal stress protein family - - - - - - - - - - - - Usp k59_966266_2 583355.Caka_1049 2.77e-12 68.2 COG0280@1|root,COG0280@2|Bacteria,46SP5@74201|Verrucomicrobia,3K793@414999|Opitutae 414999|Opitutae C Phosphate acetyl/butaryl transferase - - 2.3.1.8 ko:K00625 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - PTA_PTB k59_819287_1 1229172.JQFA01000002_gene4509 1.31e-17 85.5 COG0400@1|root,COG0400@2|Bacteria,1G525@1117|Cyanobacteria,1HAT5@1150|Oscillatoriales 1117|Cyanobacteria S phospholipase Carboxylesterase sll1284 - - ko:K06999 - - - - ko00000 - - - Abhydrolase_2 k59_179257_1 1144275.COCOR_03065 1.46e-42 147.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2WJMN@28221|Deltaproteobacteria,2YU2D@29|Myxococcales 28221|Deltaproteobacteria J TIGRFAM methionine aminopeptidase, type I map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_179257_2 1313293.BAN_0098600 4.46e-20 82.4 COG0361@1|root,COG0361@2|Bacteria,2J8JW@203691|Spirochaetes 203691|Spirochaetes J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_1072164_1 45157.CME136CT 1.44e-09 58.5 COG0451@1|root,KOG1429@2759|Eukaryota 2759|Eukaryota GM UDP-glucuronate decarboxylase activity UXS1 GO:0000139,GO:0000166,GO:0001501,GO:0001503,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006022,GO:0006023,GO:0006024,GO:0006029,GO:0006082,GO:0006139,GO:0006725,GO:0006790,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009888,GO:0009987,GO:0012505,GO:0015012,GO:0016020,GO:0016043,GO:0016829,GO:0016830,GO:0016831,GO:0016835,GO:0016836,GO:0018130,GO:0019305,GO:0019321,GO:0019438,GO:0019538,GO:0022607,GO:0030166,GO:0030198,GO:0030201,GO:0030203,GO:0030204,GO:0030206,GO:0031090,GO:0031410,GO:0031982,GO:0031984,GO:0032501,GO:0032502,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0042732,GO:0042802,GO:0042803,GO:0043062,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0046383,GO:0046483,GO:0046983,GO:0048037,GO:0048040,GO:0048513,GO:0048731,GO:0048856,GO:0050650,GO:0050654,GO:0050662,GO:0051216,GO:0051259,GO:0051262,GO:0051287,GO:0055086,GO:0061448,GO:0065003,GO:0070403,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0097708,GO:0098588,GO:0098791,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903510 4.1.1.35 ko:K08678 ko00520,ko01100,map00520,map01100 M00361 R01384 RC00508 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_394044_1 665571.STHERM_c17700 1.67e-25 106.0 COG0508@1|root,COG0508@2|Bacteria,2J5U3@203691|Spirochaetes 203691|Spirochaetes C dehydrogenase complex catalyzes the overall conversion of - - - - - - - - - - - - 2-oxoacid_dh k59_394044_2 1280698.AUJS01000032_gene1985 9.94e-20 87.8 COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,27VCX@189330|Dorea 186801|Clostridia O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1649967_1 323261.Noc_1074 7.26e-39 132.0 arCOG11477@1|root,32TJG@2|Bacteria,1MYXX@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF4242) - - - - - - - - - - - - DUF4242 k59_1124160_1 247634.GPB2148_3501 4.47e-17 87.4 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1Q33X@1224|Proteobacteria,1RNSN@1236|Gammaproteobacteria,1J69A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria GT Pyruvate phosphate dikinase, PEP/pyruvate binding domain - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016999,GO:0017000,GO:0017144,GO:0044237,GO:0044249 2.7.9.2 ko:K01007,ko:K21787 ko00333,ko00620,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00333,map00620,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00374,M00837,M00838 R00199,R11662,R11673 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_87082_1 983917.RGE_44010 3.19e-18 93.6 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,1KJSR@119065|unclassified Burkholderiales 28216|Betaproteobacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_862779_1 264198.Reut_B4231 1.73e-21 99.8 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,2VJUV@28216|Betaproteobacteria,1KGU8@119060|Burkholderiaceae 28216|Betaproteobacteria G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_1018982_1 1380394.JADL01000001_gene2710 2.86e-40 152.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria,2JPMY@204441|Rhodospirillales 204441|Rhodospirillales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_4,Toprim_N,zf-CHC2 k59_915489_1 1445613.JALM01000020_gene4789 1.08e-29 122.0 COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria,4DY4S@85010|Pseudonocardiales 201174|Actinobacteria EQ PFAM Hydantoinase oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_1018988_1 1485544.JQKP01000001_gene928 3.25e-113 350.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,44VDQ@713636|Nitrosomonadales 28216|Betaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_341020_1 1279017.AQYJ01000026_gene58 1.24e-31 127.0 COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,1R5G4@1224|Proteobacteria,1SEWA@1236|Gammaproteobacteria,469S7@72275|Alteromonadaceae 1236|Gammaproteobacteria M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11,SdrD_B k59_1593519_1 247490.KSU1_D0399 1.59e-23 96.7 COG2095@1|root,COG2095@2|Bacteria,2J0YY@203682|Planctomycetes 203682|Planctomycetes U MarC family integral membrane protein - - - - - - - - - - - - MarC k59_288768_1 425104.Ssed_0246 2.4e-27 108.0 COG4798@1|root,COG4798@2|Bacteria,1RHGZ@1224|Proteobacteria,1S2WK@1236|Gammaproteobacteria,2QBNE@267890|Shewanellaceae 1236|Gammaproteobacteria S Methyl-transferase - - - - - - - - - - - - Methyltransf_11,PCMT,Ubie_methyltran k59_1534166_1 1123060.JONP01000009_gene2105 3.39e-71 234.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,2JQVG@204441|Rhodospirillales 204441|Rhodospirillales O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_757774_1 196490.AUEZ01000119_gene6403 2.23e-14 77.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,3JURJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_966307_1 861299.J421_3780 2.72e-134 418.0 COG0178@1|root,COG0178@2|Bacteria,1ZT1W@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1496756_1 290397.Adeh_0405 3.52e-42 148.0 COG1475@1|root,COG1475@2|Bacteria,1Q2AH@1224|Proteobacteria,437X8@68525|delta/epsilon subdivisions,2X9QN@28221|Deltaproteobacteria,2YUMN@29|Myxococcales 28221|Deltaproteobacteria K ParB-like nuclease domain - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_1593528_2 1121877.JQKF01000022_gene2302 4.02e-41 152.0 COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4CMQB@84992|Acidimicrobiia 84992|Acidimicrobiia C Aconitase family (aconitate hydratase) - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1172349_1 1121920.AUAU01000011_gene174 7e-43 155.0 COG0008@1|root,COG0008@2|Bacteria,3Y7DS@57723|Acidobacteria 57723|Acidobacteria J tRNA synthetases class I (E and Q), anti-codon binding domain - - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_1172349_2 326424.FRAAL1590 1.14e-27 107.0 COG2764@1|root,COG2764@2|Bacteria,2GMZD@201174|Actinobacteria,4EVHP@85013|Frankiales 201174|Actinobacteria S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K04750 - - - - ko00000 - - - Glyoxalase k59_1172349_3 1101189.AQUO01000002_gene649 2.9e-11 67.0 COG0451@1|root,COG0673@1|root,COG0451@2|Bacteria,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,2TT7Y@28211|Alphaproteobacteria,2PWBU@265|Paracoccus 28211|Alphaproteobacteria GM NmrA-like family - - - - - - - - - - - - Epimerase,GFO_IDH_MocA,GFO_IDH_MocA_C k59_179293_1 1267533.KB906733_gene3308 6.17e-41 142.0 COG1607@1|root,COG1607@2|Bacteria,3Y53T@57723|Acidobacteria,2JMAX@204432|Acidobacteriia 204432|Acidobacteriia I PFAM thioesterase superfamily - - - - - - - - - - - - 4HBT k59_341053_1 1003200.AXXA_02502 8.47e-50 172.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2VHAR@28216|Betaproteobacteria,3T2JH@506|Alcaligenaceae 28216|Betaproteobacteria G Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides nagZ - 2.7.8.7,3.2.1.52 ko:K00997,ko:K01207 ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501 M00628 R00022,R01625,R05963,R07809,R07810,R10831 RC00002,RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_87162_2 330214.NIDE1351 1.27e-25 99.8 COG3168@1|root,COG3168@2|Bacteria,3J1AT@40117|Nitrospirae 40117|Nitrospirae NU Pilus assembly protein, PilP - - - ko:K02665 - - - - ko00000,ko02035,ko02044 - - - PilP k59_662266_1 1390370.O203_02850 1.29e-29 124.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1YJ29@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,MASE1,PAS_4,PAS_9 k59_288806_1 518766.Rmar_1009 1.27e-11 70.5 COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes 976|Bacteroidetes T universal stress protein - - - - - - - - - - - - Usp k59_601411_1 1163617.SCD_n02780 2.58e-131 385.0 COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,2VKQB@28216|Betaproteobacteria 28216|Betaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_1124250_1 204669.Acid345_0997 2.04e-83 266.0 COG0449@1|root,COG0449@2|Bacteria,3Y2NE@57723|Acidobacteria,2JI69@204432|Acidobacteriia 204432|Acidobacteriia M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_1019026_1 395019.Bmul_2674 1.89e-42 155.0 COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,2VJ44@28216|Betaproteobacteria,1K0NB@119060|Burkholderiaceae 28216|Betaproteobacteria Q PFAM Mammalian cell entry related domain protein pqiB - - ko:K06192 - - - - ko00000 - - - MlaD k59_12891_1 765911.Thivi_0416 1.2e-145 423.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,1WW9J@135613|Chromatiales 135613|Chromatiales F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_548503_1 861299.J421_0755 1.64e-54 190.0 COG0515@1|root,COG0515@2|Bacteria,1ZT5R@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1289314_1 1207063.P24_08229 5.18e-73 224.0 COG1765@1|root,COG1765@2|Bacteria,1R9XU@1224|Proteobacteria,2U6E4@28211|Alphaproteobacteria,2JS0C@204441|Rhodospirillales 204441|Rhodospirillales O OsmC-like protein - - - - - - - - - - - - OsmC k59_446735_1 579138.Zymop_1106 5.99e-10 61.6 COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,2UA4W@28211|Alphaproteobacteria,2K5CB@204457|Sphingomonadales 204457|Sphingomonadales T response regulator - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_341087_1 62928.azo2149 3.48e-99 307.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2VKAN@28216|Betaproteobacteria,2KVQH@206389|Rhodocyclales 206389|Rhodocyclales I Acetyl-coenzyme A synthetase N-terminus acsA - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_503383_1 177437.HRM2_10340 1.81e-16 80.1 COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,42R3P@68525|delta/epsilon subdivisions,2WMVW@28221|Deltaproteobacteria,2MJGY@213118|Desulfobacterales 28221|Deltaproteobacteria M Phospholipase A1 - - 3.1.1.32,3.1.1.4 ko:K01058 ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110 - R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko01000 - - - PLA1 k59_503383_2 468059.AUHA01000004_gene2061 5.04e-15 72.0 COG4276@1|root,COG4276@2|Bacteria,4NQJG@976|Bacteroidetes,1ISKP@117747|Sphingobacteriia 976|Bacteroidetes S SRPBCC domain-containing protein - - - - - - - - - - - - Polyketide_cyc k59_1124272_1 448385.sce0969 2.21e-24 105.0 COG1409@1|root,COG1409@2|Bacteria,1R0BM@1224|Proteobacteria,43CTY@68525|delta/epsilon subdivisions,2X81I@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - - - - - - - - - - - k59_707633_1 298654.FraEuI1c_5999 8.6e-18 88.6 COG2159@1|root,COG2159@2|Bacteria,2IEQP@201174|Actinobacteria 201174|Actinobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_133982_1 998674.ATTE01000001_gene734 1.14e-84 265.0 COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria,463WT@72273|Thiotrichales 72273|Thiotrichales CP Proton-conducting membrane transporter - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_1072292_1 1267535.KB906767_gene5278 9.53e-19 90.1 COG0508@1|root,COG0508@2|Bacteria,3Y3CV@57723|Acidobacteria,2JHPY@204432|Acidobacteriia 204432|Acidobacteriia C e3 binding domain - - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1442664_1 1198232.CYCME_0292 1.83e-100 309.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,460VE@72273|Thiotrichales 72273|Thiotrichales S Sodium:solute symporter family - - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_1172384_1 13690.CP98_00104 9.27e-39 146.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,2K9G5@204457|Sphingomonadales 204457|Sphingomonadales EQ Hydantoinase B/oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_1289338_1 690850.Desaf_0477 1.63e-65 216.0 COG2367@1|root,COG2367@2|Bacteria,1R4Y9@1224|Proteobacteria,42YC9@68525|delta/epsilon subdivisions,2WTSH@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Beta-lactamase - - - - - - - - - - - - - k59_1233178_1 1173022.Cri9333_4061 2e-33 133.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1G2UN@1117|Cyanobacteria,1H977@1150|Oscillatoriales 1117|Cyanobacteria G Alpha amylase, catalytic domain - - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - APH,Alpha-amylase,Malt_amylase_C k59_87212_1 316274.Haur_4974 1.46e-96 308.0 COG0542@1|root,COG0542@2|Bacteria,2G5QU@200795|Chloroflexi,3758N@32061|Chloroflexia 32061|Chloroflexia O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_757835_2 1278307.KB906999_gene33 1.24e-43 150.0 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Outer membrane lipoprotein-sorting protein VP1287 - - - - - - - - - - - LolA_like k59_819421_1 1121937.AUHJ01000012_gene2803 3.91e-155 447.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,4653Y@72275|Alteromonadaceae 1236|Gammaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_1289344_2 1380355.JNIJ01000034_gene4325 3.01e-47 165.0 COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2TU3A@28211|Alphaproteobacteria,3JW29@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MA20_06335 - 4.2.1.156,4.2.1.42,5.1.2.2 ko:K01781,ko:K20023 ko00053,ko00627,ko01120,map00053,map00627,map01120 - R03791,R04161,R05608 RC00543,RC00998 ko00000,ko00001,ko01000 - - - MR_MLE_C,MR_MLE_N k59_134011_1 95619.PM1_0200500 4.3e-55 185.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iJN746.PP_0436 S4,tRNA-synt_1b k59_341124_2 1056820.KB900631_gene2315 3.53e-125 400.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,2PND5@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria NU Neisseria PilC beta-propeller domain pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_87230_1 751994.AGIG01000017_gene55 1.18e-53 176.0 COG0457@1|root,COG0457@2|Bacteria,1QZ3D@1224|Proteobacteria 1224|Proteobacteria S Putative 2OG-Fe(II) oxygenase - - - - - - - - - - - - 2OG-FeII_Oxy_5 k59_235596_1 675635.Psed_6787 3.65e-16 83.6 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4DZF9@85010|Pseudonocardiales 201174|Actinobacteria C PFAM CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1328748_1 290315.Clim_0179 5.61e-98 297.0 COG0334@1|root,COG0334@2|Bacteria,1FE0H@1090|Chlorobi 1090|Chlorobi C Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_708652_2 378806.STAUR_5012 1.05e-55 195.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2YUJI@29|Myxococcales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1173289_1 1260251.SPISAL_02180 1.11e-37 133.0 COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1WWJB@135613|Chromatiales 135613|Chromatiales E PFAM Amino acid-binding ACT - - - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT_6 k59_143834_1 1249627.D779_1207 9.4e-41 148.0 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1WXBQ@135613|Chromatiales 135613|Chromatiales O PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_299255_1 469383.Cwoe_4214 5.43e-116 343.0 COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria 201174|Actinobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit - - 6.2.1.18 ko:K15232 ko00720,ko01100,ko01120,ko01200,map00720,map01100,map01120,map01200 M00173 R01322 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2 k59_1301269_1 1123073.KB899241_gene3409 1.77e-60 205.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria,1X3GK@135614|Xanthomonadales 135614|Xanthomonadales S COG0457 FOG TPR repeat - - - - - - - - - - - - Sulfotransfer_3,TPR_16,TPR_19,TPR_8 k59_186705_1 265072.Mfla_0022 9.14e-11 66.6 2A4J7@1|root,315VR@2|Bacteria,1NPWX@1224|Proteobacteria,2WGX3@28216|Betaproteobacteria,2KMVM@206350|Nitrosomonadales 206350|Nitrosomonadales S zinc-ribbon domain - - - - - - - - - - - - DUF3426,zinc_ribbon_5 k59_1450366_1 1121935.AQXX01000098_gene1656 7.57e-16 75.5 COG3807@1|root,COG3807@2|Bacteria,1RE8W@1224|Proteobacteria,1S4BU@1236|Gammaproteobacteria,1XPIQ@135619|Oceanospirillales 135619|Oceanospirillales S COG3103 SH3 domain protein - - - - - - - - - - - - OMP_b-brl,SH3_3,SH3_4 k59_1450366_2 1056820.KB900648_gene3029 1.75e-08 58.2 COG3637@1|root,COG3637@2|Bacteria,1MZ2M@1224|Proteobacteria,1S87J@1236|Gammaproteobacteria,2PQ8I@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_1541603_1 865861.AZSU01000001_gene25 1.82e-45 148.0 COG0185@1|root,COG0185@2|Bacteria,1V6CX@1239|Firmicutes,24JN3@186801|Clostridia,36JHK@31979|Clostridiaceae 186801|Clostridia J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_1027350_1 402881.Plav_1773 1.25e-54 183.0 COG4638@1|root,COG4638@2|Bacteria,1RBGZ@1224|Proteobacteria,2U82S@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_870999_1 879212.DespoDRAFT_02660 8.77e-39 144.0 COG3385@1|root,COG3385@2|Bacteria,1NNH0@1224|Proteobacteria 1224|Proteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - - k59_515449_1 357808.RoseRS_0020 6.09e-47 153.0 arCOG07672@1|root,32Z5Y@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4258) - - - - - - - - - - - - DUF4258 k59_515449_2 1173028.ANKO01000171_gene3849 6.75e-31 110.0 2EF9F@1|root,3392C@2|Bacteria,1GRBP@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_1180160_1 203122.Sde_3549 6.8e-30 116.0 COG3807@1|root,COG3807@2|Bacteria,1RE8W@1224|Proteobacteria,1S4BU@1236|Gammaproteobacteria,46D3W@72275|Alteromonadaceae 1236|Gammaproteobacteria S Bacterial SH3 domain - - - - - - - - - - - - OMP_b-brl,SH3_3,SH3_4 k59_1180160_2 1453501.JELR01000002_gene1336 6.78e-09 56.2 COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,46408@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG0823 Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - PD40 k59_401802_1 644966.Tmar_2218 2.96e-41 148.0 COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,2498Z@186801|Clostridia,3WCJR@538999|Clostridiales incertae sedis 186801|Clostridia E RadC-like JAB domain radC - - ko:K03630 - - - - ko00000 - - - RadC k59_1134902_1 997296.PB1_15509 9.54e-43 159.0 COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,4H9XC@91061|Bacilli,1ZB9E@1386|Bacillus 91061|Bacilli J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_143871_1 436308.Nmar_0285 1.33e-39 145.0 COG1009@1|root,arCOG01539@2157|Archaea,41SC4@651137|Thaumarchaeota 651137|Thaumarchaeota C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_143871_2 1229909.NSED_01320 9.88e-52 176.0 COG1009@1|root,arCOG01539@2157|Archaea,41TBF@651137|Thaumarchaeota 651137|Thaumarchaeota C Proton-conducting membrane transporter - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_401807_2 1500890.JQNL01000001_gene1675 1.36e-30 122.0 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RXZ5@1236|Gammaproteobacteria,1X4RH@135614|Xanthomonadales 135614|Xanthomonadales K Transcriptional regulator rbcR - - - - - - - - - - - HTH_1,LysR_substrate k59_1662191_1 930166.CD58_08625 1.9e-85 260.0 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria 1236|Gammaproteobacteria H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_2376 Methyltransf_23 k59_186746_4 742727.HMPREF9447_04887 9.57e-12 65.5 2ATH2@1|root,31J0S@2|Bacteria,4PK79@976|Bacteroidetes,2FYU9@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1662200_1 269796.Rru_A1205 4.64e-07 50.4 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2TQYF@28211|Alphaproteobacteria,2JPYJ@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family sdhB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_17,Fer4_8 k59_1662200_2 1089552.KI911559_gene640 1.03e-51 180.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2TQJA@28211|Alphaproteobacteria,2JP96@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_716455_1 240292.Ava_1427 9.67e-18 85.5 COG3280@1|root,COG3280@2|Bacteria,1G3IR@1117|Cyanobacteria,1HR0I@1161|Nostocales 1117|Cyanobacteria G Alpha amylase, catalytic domain treY - 5.4.99.15 ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R09995 - ko00000,ko00001,ko00002,ko01000 - GH13 - Alpha-amylase k59_557342_1 439235.Dalk_1526 8.68e-32 139.0 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,42NXT@68525|delta/epsilon subdivisions,2WIZ3@28221|Deltaproteobacteria,2MKIU@213118|Desulfobacterales 28221|Deltaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,Pkinase,TPR_12 k59_1662218_1 572477.Alvin_0438 1.04e-81 256.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1WW6E@135613|Chromatiales 135613|Chromatiales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_299319_1 530564.Psta_0742 2.64e-12 65.5 COG0377@1|root,COG0377@2|Bacteria,2IZ30@203682|Planctomycetes 203682|Planctomycetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_299319_2 929556.Solca_1350 8.22e-32 124.0 COG0838@1|root,COG0838@2|Bacteria,4NQET@976|Bacteroidetes,1ISH2@117747|Sphingobacteriia 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_1243133_1 1156919.QWC_01845 3.45e-53 184.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2VHJ8@28216|Betaproteobacteria,3T29H@506|Alcaligenaceae 28216|Betaproteobacteria J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_674381_1 1469245.JFBG01000010_gene599 6.22e-135 409.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,1X2PM@135613|Chromatiales 135613|Chromatiales C TIGRFAM formate dehydrogenase, alpha subunit - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1508964_1 443143.GM18_3440 3.2e-16 80.9 COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,42NJT@68525|delta/epsilon subdivisions,2WM7E@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM NAD-dependent epimerase dehydratase hpnA - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase k59_1508964_2 67352.JODS01000034_gene7641 6.1e-27 105.0 COG0379@1|root,COG0379@2|Bacteria,2GKCM@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate - - - - - - - - - - - - - k59_1301375_1 1229909.NSED_04605 6.08e-50 160.0 arCOG08697@1|root,arCOG08697@2157|Archaea,41SUN@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_831539_1 296591.Bpro_0293 7.08e-30 114.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VJ9Y@28216|Betaproteobacteria,4AC5K@80864|Comamonadaceae 28216|Betaproteobacteria K LuxR family transcriptional regulator - - - - - - - - - - - - GerE,Response_reg k59_831539_2 909663.KI867150_gene366 1.74e-19 89.0 COG4585@1|root,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,42RUN@68525|delta/epsilon subdivisions,2WNJZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria T ATP-binding region ATPase domain protein - - - - - - - - - - - - CHASE4,HATPase_c,HisKA_3,PAS_3,PAS_4,PAS_9 k59_1336436_3 1410613.JNKF01000011_gene950 3.11e-28 107.0 COG3023@1|root,COG3023@2|Bacteria 2|Bacteria V N-Acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - Amidase_2,LysM,PG_binding_1 k59_1243146_1 330214.NIDE3786 7.15e-71 237.0 COG0474@1|root,COG0474@2|Bacteria,3J0WH@40117|Nitrospirae 40117|Nitrospirae P Cation transporter/ATPase, N-terminus - - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_1508975_1 1158165.KB898872_gene788 2.17e-68 222.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1WW94@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_515525_2 383372.Rcas_0040 1.81e-09 55.5 COG1324@1|root,COG1324@2|Bacteria,2GAUD@200795|Chloroflexi,377VA@32061|Chloroflexia 32061|Chloroflexia P PFAM CutA1 divalent ion tolerance protein - - - ko:K03926 - - - - ko00000 - - - CutA1 k59_871059_1 497964.CfE428DRAFT_3091 2.27e-54 177.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - - ko:K06219 - - - - ko00000 - - - Methyltransf_11,Methyltransf_23,Methyltransf_25 k59_871059_2 391612.CY0110_20760 2.93e-11 64.3 COG0438@1|root,COG0438@2|Bacteria,1G2T9@1117|Cyanobacteria 1117|Cyanobacteria M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_557374_1 1191523.MROS_0711 5.12e-110 330.0 COG0493@1|root,COG0493@2|Bacteria 2|Bacteria C 'glutamate synthase gltD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iJN678.gltD,iNJ661.Rv3858c,iSB619.SA_RS02450 Fer4_20,Pyr_redox_2 k59_351482_1 439235.Dalk_1700 1.82e-56 194.0 COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,43BR1@68525|delta/epsilon subdivisions,2WIIS@28221|Deltaproteobacteria,2MIQ9@213118|Desulfobacterales 28221|Deltaproteobacteria P Catalyzes the synthesis of activated sulfate cysC - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,ATP-sulfurylase,PUA_2 k59_717545_1 449673.BACSTE_01305 9.2e-39 136.0 COG0110@1|root,COG0110@2|Bacteria,4NENC@976|Bacteroidetes,2FP5Y@200643|Bacteroidia,4AQ60@815|Bacteroidaceae 976|Bacteroidetes S Bacterial transferase hexapeptide repeat protein fdtC - 2.3.1.201 ko:K13018 ko00520,map00520 - R10100 RC00004,RC00166 ko00000,ko00001,ko01000,ko01005 - - - Hexapep,Hexapep_2 k59_717545_2 1157490.EL26_10820 9.36e-09 56.2 COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,4HAD8@91061|Bacilli,2785S@186823|Alicyclobacillaceae 91061|Bacilli M Cell wall formation murB GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_558448_1 278963.ATWD01000001_gene3111 1.87e-11 64.3 COG0360@1|root,COG0360@2|Bacteria,3Y50N@57723|Acidobacteria,2JJHP@204432|Acidobacteriia 204432|Acidobacteriia J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_558448_2 1304885.AUEY01000010_gene1648 2.51e-14 68.9 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,42VJQ@68525|delta/epsilon subdivisions,2WR7Z@28221|Deltaproteobacteria,2MKM0@213118|Desulfobacterales 28221|Deltaproteobacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_245514_1 236097.ADG881_1727 1.3e-78 244.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1XIHC@135619|Oceanospirillales 135619|Oceanospirillales O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_99124_1 138119.DSY3657 6.94e-05 48.9 COG0845@1|root,COG0845@2|Bacteria,1UUEP@1239|Firmicutes,24CTR@186801|Clostridia,262XV@186807|Peptococcaceae 186801|Clostridia M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_99124_2 1047013.AQSP01000078_gene2055 1.62e-07 53.9 COG1538@1|root,COG1538@2|Bacteria,2NP5D@2323|unclassified Bacteria 2|Bacteria MU Outer membrane efflux protein tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_402940_1 33898.JRHJ01000082_gene1692 3.79e-27 110.0 COG0726@1|root,COG0726@2|Bacteria,2H6C7@201174|Actinobacteria 201174|Actinobacteria G polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_1136031_1 519989.ECTPHS_00170 5.36e-80 252.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1WW6N@135613|Chromatiales 135613|Chromatiales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_1451280_1 396588.Tgr7_0365 1.05e-64 198.0 COG2920@1|root,COG2920@2|Bacteria 2|Bacteria P part of a sulfur-relay system - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_717564_1 292415.Tbd_0991 2.93e-24 99.0 COG0596@1|root,COG0596@2|Bacteria,1RJQK@1224|Proteobacteria,2W4YC@28216|Betaproteobacteria 28216|Betaproteobacteria S Alpha beta hydrolase - - - - - - - - - - - - - k59_717564_2 1385517.N800_04310 1.46e-42 147.0 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,1X3YK@135614|Xanthomonadales 135614|Xanthomonadales P nucleotidase cysQ - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_99139_1 1283284.AZUK01000001_gene1737 1.03e-73 229.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1Y4P3@135624|Aeromonadales 135624|Aeromonadales M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - - - - - - - - - - - - LGT k59_1337342_1 570967.JMLV01000002_gene1603 5.92e-34 124.0 COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2TRIB@28211|Alphaproteobacteria,2JTKV@204441|Rhodospirillales 204441|Rhodospirillales Q Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - - - - - - - - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 k59_1337342_2 1287116.X734_21145 6.85e-56 183.0 COG1600@1|root,COG1600@2|Bacteria,1R9XX@1224|Proteobacteria,2UA5Q@28211|Alphaproteobacteria,43H2J@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C COG1145 Ferredoxin - - - - - - - - - - - - - k59_144745_1 1121918.ARWE01000001_gene647 2.04e-42 158.0 COG0297@1|root,COG0366@1|root,COG0297@2|Bacteria,COG0366@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,43U7I@69541|Desulfuromonadales 28221|Deltaproteobacteria G Starch synthase catalytic domain glgA-2 GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Alpha-amylase,Glyco_transf_5,Glycos_transf_1 k59_155380_1 652103.Rpdx1_3732 4.52e-83 254.0 COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,2TZ7M@28211|Alphaproteobacteria,3JY2X@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - LZ_Tnp_IS481,rve,rve_3 k59_469060_1 107635.AZUO01000004_gene3872 8.69e-43 160.0 COG0673@1|root,COG1063@1|root,COG0673@2|Bacteria,COG1063@2|Bacteria,1PE6Y@1224|Proteobacteria,2V8CT@28211|Alphaproteobacteria,36Z51@31993|Methylocystaceae 28211|Alphaproteobacteria E Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - ADH_zinc_N,GFO_IDH_MocA k59_568497_2 357808.RoseRS_2666 3.73e-49 172.0 COG1131@1|root,COG1131@2|Bacteria,2GAPH@200795|Chloroflexi,375EU@32061|Chloroflexia 32061|Chloroflexia V PFAM ABC transporter related - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1403335_1 1173026.Glo7428_4026 3.08e-29 111.0 COG0529@1|root,COG0529@2|Bacteria,1G5DN@1117|Cyanobacteria 1117|Cyanobacteria P Catalyzes the synthesis of activated sulfate - - 2.7.1.25 ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase k59_1348015_1 1444309.JAQG01000019_gene567 2.4e-40 145.0 COG0688@1|root,COG0688@2|Bacteria,1TR34@1239|Firmicutes,4HB6I@91061|Bacilli,26QJB@186822|Paenibacillaceae 91061|Bacilli I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_1038463_1 742159.HMPREF0004_4024 8.41e-11 66.6 COG1028@1|root,COG1028@2|Bacteria,1N907@1224|Proteobacteria,2VMTP@28216|Betaproteobacteria,3T7BA@506|Alcaligenaceae 28216|Betaproteobacteria C KR domain - - - - - - - - - - - - adh_short_C2 k59_1191843_1 384765.SIAM614_24167 9.02e-16 76.6 COG4665@1|root,COG4665@2|Bacteria,1R4T4@1224|Proteobacteria,2U2FK@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - - - - - - - - - - DctQ k59_1191843_2 991905.SL003B_0825 3.22e-53 186.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,4BPV8@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - - - - - - - - - - DctM k59_469092_1 227377.CBU_1074 5.05e-52 171.0 COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,1RNPQ@1236|Gammaproteobacteria,1JCVQ@118969|Legionellales 118969|Legionellales F Phosphoribosyl transferase domain ppt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_469092_2 640081.Dsui_2698 1.99e-10 60.1 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2VJQQ@28216|Betaproteobacteria,2KV4J@206389|Rhodocyclales 206389|Rhodocyclales F Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage - - 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_1038471_1 1469245.JFBG01000102_gene1328 2.99e-95 286.0 COG2141@1|root,COG2141@2|Bacteria,1MXQU@1224|Proteobacteria 1224|Proteobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_363421_1 1121861.KB899930_gene227 1.36e-12 66.6 COG2010@1|root,COG2010@2|Bacteria,1RGXM@1224|Proteobacteria,2U95Y@28211|Alphaproteobacteria,2JTR2@204441|Rhodospirillales 204441|Rhodospirillales C COG2010 Cytochrome c, mono- and diheme variants - - - - - - - - - - - - Cytochrome_CBB3 k59_311687_1 338963.Pcar_1826 6.82e-37 134.0 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,42TYM@68525|delta/epsilon subdivisions,2WQ12@28221|Deltaproteobacteria,43SNZ@69541|Desulfuromonadales 28221|Deltaproteobacteria S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_363428_1 330214.NIDE3392 1.28e-63 216.0 COG1449@1|root,COG1449@2|Bacteria,3J0AQ@40117|Nitrospirae 40117|Nitrospirae G Glycosyl hydrolase family 57 - - - - - - - - - - - - Glyco_hydro_57 k59_255563_1 1303518.CCALI_02898 2.34e-134 414.0 COG0209@1|root,COG0209@2|Bacteria 2|Bacteria F ribonucleoside-diphosphate reductase activity nrdJ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC k59_621998_1 1123073.KB899242_gene907 5.53e-70 238.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1X3MQ@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_1191881_1 94122.Shewana3_0976 1.54e-10 59.7 2C39R@1|root,32UYY@2|Bacteria,1NMIM@1224|Proteobacteria,1SFZP@1236|Gammaproteobacteria,2QC0N@267890|Shewanellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1191881_2 392500.Swoo_4061 1.33e-16 76.6 2C39R@1|root,32UYY@2|Bacteria,1NMIM@1224|Proteobacteria,1SFZP@1236|Gammaproteobacteria,2QC0N@267890|Shewanellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_469136_1 1163617.SCD_n02473 8.35e-51 170.0 COG2981@1|root,COG2981@2|Bacteria,1Q181@1224|Proteobacteria,2VN29@28216|Betaproteobacteria 28216|Betaproteobacteria E Etoposide-induced protein 2.4 (EI24) - - - - - - - - - - - - EI24 k59_363453_1 713586.KB900536_gene2943 4.71e-45 151.0 COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,1RRXT@1236|Gammaproteobacteria,1X2ET@135613|Chromatiales 135613|Chromatiales F Deoxynucleoside kinase - - - - - - - - - - - - dNK k59_363453_2 1415778.JQMM01000001_gene159 3.33e-16 75.5 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,1S63J@1236|Gammaproteobacteria,1J6J2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase folK GO:0000287,GO:0003674,GO:0003824,GO:0003848,GO:0005488,GO:0016740,GO:0016772,GO:0016778,GO:0043167,GO:0043169,GO:0046872 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iECDH1ME8569_1439.ECDH1ME8569_0136,iEcDH1_1363.EcDH1_3460,iJN746.PP_4698,iSBO_1134.SBO_0131 HPPK k59_1038503_2 55529.EKX50212 3.72e-18 87.4 28H8X@1|root,2T1B8@2759|Eukaryota 2759|Eukaryota - - - - - - - - - - - - - - - k59_1348099_1 43989.cce_4098 2.03e-06 52.4 COG2159@1|root,COG2159@2|Bacteria,1G3DV@1117|Cyanobacteria,3KGJS@43988|Cyanothece 1117|Cyanobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1348099_2 1134912.AJTV01000061_gene3984 3.12e-36 143.0 COG4872@1|root,COG4872@2|Bacteria,1N3FM@1224|Proteobacteria 1224|Proteobacteria S Predicted membrane protein (DUF2157) - - - - - - - - - - - - DUF2157 k59_1191906_2 999413.HMPREF1094_01452 6.43e-06 50.1 COG1051@1|root,COG1051@2|Bacteria,1UIGB@1239|Firmicutes,3VQYC@526524|Erysipelotrichia 526524|Erysipelotrichia F NUDIX domain - - - - - - - - - - - - NUDIX k59_1462071_1 1121033.AUCF01000008_gene5710 1.38e-99 296.0 COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2TR0I@28211|Alphaproteobacteria,2JQCA@204441|Rhodospirillales 204441|Rhodospirillales G Polysaccharide deacetylase - - 3.5.1.41 ko:K01452 ko00520,ko01100,map00520,map01100 - R02333 RC00166,RC00300 ko00000,ko00001,ko01000 - - - Polysacc_deac_1 k59_155477_1 42256.RradSPS_0131 6.33e-125 372.0 COG1819@1|root,COG1819@2|Bacteria,2GJN7@201174|Actinobacteria,4CQX3@84995|Rubrobacteria 84995|Rubrobacteria CG UDP-glucoronosyl and UDP-glucosyl transferase - - - - - - - - - - - - UDPGT k59_311739_1 292563.Cyast_0460 4.29e-22 96.7 COG2230@1|root,COG2230@2|Bacteria,1G3JT@1117|Cyanobacteria 1117|Cyanobacteria M cyclopropane-fatty-acyl-phospholipid synthase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_1191928_1 247634.GPB2148_831 7.99e-16 80.1 COG2358@1|root,COG2358@2|Bacteria 2|Bacteria G TRAP transporter, solute receptor (TAXI family - - - - - - - - - - - - NMT1_3 k59_414900_1 467200.ACFA01000629_gene6257 6.22e-07 55.5 COG1309@1|root,COG1309@2|Bacteria,2HG87@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - TetR_N k59_363480_1 268746.Q58MP3_BPPRM 5.83e-36 141.0 4QBUC@10239|Viruses,4QQGQ@28883|Caudovirales,4QHY3@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_1348124_1 1122238.AULR01000001_gene1934 6.53e-26 108.0 COG0248@1|root,COG0248@2|Bacteria,2GMME@201174|Actinobacteria,4FKY7@85023|Microbacteriaceae 201174|Actinobacteria FP Ppx/GppA phosphatase family ppx1 GO:0003674,GO:0003824,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0044237 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_1148801_1 78898.MVEG_02603T0 1.64e-108 330.0 COG0129@1|root,KOG2448@2759|Eukaryota,38F28@33154|Opisthokonta,3NUBR@4751|Fungi,1GS3V@112252|Fungi incertae sedis 4751|Fungi E Dehydratase family ILV3 GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006549,GO:0006551,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_622060_2 765914.ThisiDRAFT_1060 2.49e-48 166.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1WW0V@135613|Chromatiales 135613|Chromatiales M lipoprotein releasing system, transmembrane protein, LolC E family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_985702_1 1123073.KB899241_gene2322 2.59e-27 115.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1X4ZI@135614|Xanthomonadales 135614|Xanthomonadales U AAA domain - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_365293_1 588581.Cpap_0796 1.15e-11 67.8 COG1251@1|root,COG1251@2|Bacteria,1TQYX@1239|Firmicutes,24AD5@186801|Clostridia,3WHY7@541000|Ruminococcaceae 186801|Clostridia C pyridine nucleotide-disulfide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_1611575_1 436308.Nmar_1604 2.63e-54 179.0 COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota 651137|Thaumarchaeota K Phosphate uptake regulator - - - - - - - - - - - - MazE_antitoxin,PhoU k59_1611575_2 436308.Nmar_1603 9.24e-40 135.0 COG1370@1|root,arCOG00991@2157|Archaea,41SP1@651137|Thaumarchaeota 651137|Thaumarchaeota O Patch-forming domain C2 of tRNA-guanine transglycosylase - - - ko:K07398 - - - - ko00000 - - - PUA,TGT_C2 k59_1405626_2 1279009.ADICEAN_03128 4.54e-33 124.0 COG2003@1|root,COG2003@2|Bacteria,4NFBF@976|Bacteroidetes,47KTY@768503|Cytophagia 976|Bacteroidetes E Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC k59_1556598_1 582515.KR51_00029290 8.79e-30 122.0 COG1716@1|root,COG2114@1|root,COG2203@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,COG2203@2|Bacteria,1G1FY@1117|Cyanobacteria 1117|Cyanobacteria T PFAM Adenylate and Guanylate cyclase catalytic domain cyaD - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - FHA,GAF,GAF_2,Guanylate_cyc k59_417049_1 935948.KE386495_gene2120 4.12e-45 166.0 COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,42EUK@68295|Thermoanaerobacterales 186801|Clostridia J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_987832_1 686340.Metal_1013 4.69e-150 437.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1XDJW@135618|Methylococcales 135618|Methylococcales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_987832_2 472759.Nhal_3870 5.86e-43 154.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1WWTF@135613|Chromatiales 135613|Chromatiales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane - - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_987839_1 1095769.CAHF01000025_gene629 9.64e-57 199.0 COG0657@1|root,COG2072@1|root,COG0657@2|Bacteria,COG2072@2|Bacteria,1RD8A@1224|Proteobacteria,2W97B@28216|Betaproteobacteria,474VT@75682|Oxalobacteraceae 28216|Betaproteobacteria I Steryl acetyl hydrolase - - - - - - - - - - - - Abhydrolase_3 k59_729090_1 177437.HRM2_48520 2.53e-37 138.0 COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,42NC1@68525|delta/epsilon subdivisions,2WMKG@28221|Deltaproteobacteria,2MPK8@213118|Desulfobacterales 28221|Deltaproteobacteria M Biotin-lipoyl like - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_417078_1 1121033.AUCF01000012_gene981 1.95e-38 144.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2UQQD@28211|Alphaproteobacteria,2JPWN@204441|Rhodospirillales 204441|Rhodospirillales S exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1039958_1 349521.HCH_02748 3.62e-52 177.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XH7Y@135619|Oceanospirillales 135619|Oceanospirillales T Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1039958_2 1049564.TevJSym_av00270 6.01e-34 131.0 COG4191@1|root,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,1RQ5N@1236|Gammaproteobacteria,1J539@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. prsK - - - - - - - - - - - GAF_2,HATPase_c k59_624229_2 765911.Thivi_3576 1.09e-87 288.0 COG0419@1|root,COG3264@1|root,COG0419@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1WXKG@135613|Chromatiales 135613|Chromatiales DM mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel,MscS_TM,MscS_porin k59_365356_1 1265756.AWZW01000008_gene711 7.31e-13 68.6 COG4177@1|root,COG4177@2|Bacteria,1MU52@1224|Proteobacteria,2TSUI@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_365356_2 469371.Tbis_1472 6.28e-28 109.0 COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4DY41@85010|Pseudonocardiales 201174|Actinobacteria E Branched-chain amino acid transport livG - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_365366_1 388051.AUFE01000014_gene6070 8.78e-37 132.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2VIQF@28216|Betaproteobacteria,1JZYF@119060|Burkholderiaceae 28216|Betaproteobacteria M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_365366_2 1356854.N007_09215 1.24e-09 58.2 COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,4HAKI@91061|Bacilli,277WY@186823|Alicyclobacillaceae 91061|Bacilli G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_23024_1 1348114.OM33_02810 1.01e-21 99.8 COG0834@1|root,COG1301@1|root,COG0834@2|Bacteria,COG1301@2|Bacteria,1P22C@1224|Proteobacteria,1RSGY@1236|Gammaproteobacteria,2Q21V@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3,SDF k59_624260_1 870187.Thini_0149 5.14e-31 114.0 COG2932@1|root,COG2932@2|Bacteria,1NBZE@1224|Proteobacteria,1S6MQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Peptidase S24-like - - - - - - - - - - - - Peptidase_S24 k59_624260_2 760117.JN27_06320 2.96e-26 109.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,472XR@75682|Oxalobacteraceae 28216|Betaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_2,Thioredoxin_7 k59_202223_1 1254432.SCE1572_01825 6.36e-65 222.0 COG3857@1|root,COG3857@2|Bacteria,1QXU1@1224|Proteobacteria,43C6K@68525|delta/epsilon subdivisions,2X7GU@28221|Deltaproteobacteria,2Z1DQ@29|Myxococcales 28221|Deltaproteobacteria L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1 k59_421442_1 243233.MCA1545 9e-37 139.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1XE0B@135618|Methylococcales 135618|Methylococcales H Vitamin B12 dependent methionine synthase, activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_421442_2 880070.Cycma_4722 5.8e-49 168.0 COG0372@1|root,COG0372@2|Bacteria,4NFXK@976|Bacteroidetes,47JIN@768503|Cytophagia 976|Bacteroidetes C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_159120_1 756272.Plabr_0942 3.29e-33 133.0 COG0841@1|root,COG0841@2|Bacteria,2IY0K@203682|Planctomycetes 203682|Planctomycetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1048255_2 529507.PMI2048 7.37e-72 221.0 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,3Z144@583|Proteus 1236|Gammaproteobacteria V Ami_2 ampD GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043170,GO:0044424,GO:0044464,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.5.1.28 ko:K01447,ko:K03806 - - R04112 RC00064,RC00141 ko00000,ko01000,ko01011 - - iAF1260.b0110,iB21_1397.B21_00108,iBWG_1329.BWG_0103,iEC55989_1330.EC55989_0103,iECBD_1354.ECBD_3509,iECB_1328.ECB_00109,iECDH10B_1368.ECDH10B_0090,iECDH1ME8569_1439.ECDH1ME8569_0104,iECD_1391.ECD_00109,iECIAI1_1343.ECIAI1_0107,iECO103_1326.ECO103_0110,iECO111_1330.ECO111_0111,iECO26_1355.ECO26_0112,iECSE_1348.ECSE_0110,iECW_1372.ECW_m0107,iEKO11_1354.EKO11_3806,iETEC_1333.ETEC_0106,iEcDH1_1363.EcDH1_3492,iEcE24377_1341.EcE24377A_0112,iEcHS_1320.EcHS_A0114,iEcolC_1368.EcolC_3549,iJO1366.b0110,iSFV_1184.SFV_0101,iSF_1195.SF0107,iSFxv_1172.SFxv_0113,iS_1188.S0109,iUMNK88_1353.UMNK88_108,iWFL_1372.ECW_m0107,iY75_1357.Y75_RS00560 Amidase_2 k59_369274_2 877424.ATWC01000016_gene123 8.36e-05 51.6 COG1668@1|root,COG1668@2|Bacteria,1VH3D@1239|Firmicutes,24M9N@186801|Clostridia,27KK8@186928|unclassified Lachnospiraceae 186801|Clostridia CP ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane_2,ABC2_membrane_3 k59_212449_1 1267005.KB911257_gene796 1.09e-10 61.6 28V8Y@1|root,2ZHBX@2|Bacteria,1RD5G@1224|Proteobacteria,2U0PF@28211|Alphaproteobacteria,3N7JZ@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria C Methylamine dehydrogenase, L chain mauA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.4.9.1 ko:K15228 ko00680,ko01120,map00680,map01120 - R00606 RC00189 ko00000,ko00001,ko01000 - - - Me-amine-dh_L k59_212449_2 1458357.BG58_08120 7.68e-20 90.9 COG3391@1|root,COG3391@2|Bacteria,1R8X0@1224|Proteobacteria,2VNTY@28216|Betaproteobacteria,1K4IG@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM methylamine dehydrogenase heavy subunit aauB GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.4.9.1,1.4.9.2 ko:K13372,ko:K15229 ko00350,ko00360,ko00680,ko00950,ko01100,ko01110,ko01120,map00350,map00360,map00680,map00950,map01100,map01110,map01120 - R00606,R02382,R02612,R04300 RC00062,RC00189 ko00000,ko00001,ko01000 - - - Me-amine-dh_H k59_943456_2 546273.VEIDISOL_01877 4.01e-49 168.0 COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,4H2Z8@909932|Negativicutes 909932|Negativicutes J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_1152507_1 278957.ABEA03000201_gene4325 3.93e-73 242.0 COG0444@1|root,COG4608@1|root,COG0444@2|Bacteria,COG4608@2|Bacteria,46U8E@74201|Verrucomicrobia,3KA26@414999|Opitutae 414999|Opitutae P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_1257949_1 1122201.AUAZ01000009_gene2878 2.23e-92 300.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D9@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_995609_1 330214.NIDE1308 9.68e-73 238.0 COG0480@1|root,COG0480@2|Bacteria,3J0EK@40117|Nitrospirae 40117|Nitrospirae J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_839359_1 269799.Gmet_2580 8.56e-73 245.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,43TF0@69541|Desulfuromonadales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_107632_1 666684.AfiDRAFT_1589 3.01e-79 258.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2TR5H@28211|Alphaproteobacteria,3JQXK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_631232_1 243231.GSU2502 4.98e-66 226.0 COG0421@1|root,COG0421@2|Bacteria,1QX98@1224|Proteobacteria,43C2D@68525|delta/epsilon subdivisions,2X7CZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_683399_1 1122135.KB893137_gene1194 1.02e-143 410.0 COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,2TS8M@28211|Alphaproteobacteria 28211|Alphaproteobacteria G ABC-type sugar transport system, permease component - - - ko:K05815 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.3 - - BPD_transp_1 k59_683399_2 977880.RALTA_A1916 2.82e-19 85.5 COG3568@1|root,COG3568@2|Bacteria,1R99W@1224|Proteobacteria,2VPVB@28216|Betaproteobacteria,1KG3B@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM Endonuclease exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_421470_1 344747.PM8797T_10544 1.36e-44 158.0 COG3635@1|root,COG3635@2|Bacteria,2IY5S@203682|Planctomycetes 203682|Planctomycetes G phosphoglycerate mutase - - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase k59_56599_1 1510531.JQJJ01000008_gene4253 2.83e-23 102.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,3JWX2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E ATPases associated with a variety of cellular activities - - - ko:K02052 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - ABC_tran,TOBE_2 k59_265445_3 977880.RALTA_B0003 1.77e-29 106.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria 28216|Betaproteobacteria K Cold shock protein - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_57422_2 1286632.P278_02750 1.11e-07 56.2 COG2885@1|root,COG2885@2|Bacteria,4NS8S@976|Bacteroidetes,1IK32@117743|Flavobacteriia 976|Bacteroidetes M Protein of unknown function (DUF1573) - - - - - - - - - - - - DUF1573 k59_57422_3 926560.KE387025_gene3987 3.85e-14 74.3 COG0785@1|root,COG0785@2|Bacteria,1WIZH@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O PFAM cytochrome c biogenesis protein, transmembrane region - - - - - - - - - - - - DsbD k59_1570969_1 997296.PB1_02820 1.01e-30 116.0 COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,4HIWA@91061|Bacilli,1ZH33@1386|Bacillus 91061|Bacilli M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) yjbJ - - - - - - - - - - - SLT k59_1570969_2 551789.ATVJ01000003_gene233 9.52e-28 116.0 COG2071@1|root,COG3919@1|root,COG2071@2|Bacteria,COG3919@2|Bacteria,1QX4G@1224|Proteobacteria,2TXU4@28211|Alphaproteobacteria,43XEB@69657|Hyphomonadaceae 28211|Alphaproteobacteria S ATP-grasp domain - - - - - - - - - - - - ATP-grasp_3,Peptidase_C26 k59_1414402_1 35128.Thapsdraft1360 6.49e-156 448.0 COG0719@1|root,2QRGW@2759|Eukaryota,2XEEX@2836|Bacillariophyta 2836|Bacillariophyta O Uncharacterized protein family (UPF0051) - - - - - - - - - - - - UPF0051 k59_788708_1 360094.PXO_01383 1.48e-21 94.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1X4JJ@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_788708_2 118797.XP_007462743.1 2.68e-54 186.0 COG0441@1|root,KOG1637@2759|Eukaryota,38C5Y@33154|Opisthokonta,3B9Y5@33208|Metazoa,3CVGA@33213|Bilateria,4843X@7711|Chordata,48YPS@7742|Vertebrata,3J9Q1@40674|Mammalia 33208|Metazoa J threonyl-tRNA synthetase - - - - - - - - - - - - IF3_C,IF3_N,tRNA-synt_2b,tRNA_SAD k59_788708_3 413404.Rmag_0646 5.45e-26 97.1 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,1J7AC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_1153282_1 631362.Thi970DRAFT_04466 1.22e-91 282.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1WW6N@135613|Chromatiales 135613|Chromatiales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_2368_1 1237149.C900_01082 3.5e-40 144.0 COG2876@1|root,COG2876@2|Bacteria,4NDU4@976|Bacteroidetes,47K32@768503|Cytophagia 976|Bacteroidetes E chorismate mutase pheB - 5.4.99.5 ko:K04516 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R01715 RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_2,DAHP_synth_1 k59_57442_1 436308.Nmar_1745 1.66e-78 241.0 COG0524@1|root,arCOG00014@2157|Archaea,41SX4@651137|Thaumarchaeota 651137|Thaumarchaeota G pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB k59_57442_2 1229909.NSED_09295 4.11e-32 114.0 arCOG08766@1|root,arCOG08766@2157|Archaea,41T41@651137|Thaumarchaeota 651137|Thaumarchaeota G dUTPase - - - - - - - - - - - - dUTPase_2 k59_788717_1 935567.JAES01000003_gene173 3.45e-113 340.0 COG0017@1|root,COG0017@2|Bacteria,1MWFV@1224|Proteobacteria,1RMU4@1236|Gammaproteobacteria,1X3ZM@135614|Xanthomonadales 135614|Xanthomonadales J asparaginyl-tRNA synthetase asnS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_1414415_1 768704.Desmer_0394 2.54e-05 52.0 COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia,2606F@186807|Peptococcaceae 186801|Clostridia L ATP-dependent helicase nuclease subunit A - - 3.6.4.12 ko:K16898 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_369940_1 1122169.AREN01000046_gene2147 1.75e-49 166.0 COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria,1JC4K@118969|Legionellales 118969|Legionellales C Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate tdh - 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_57443_1 1415780.JPOG01000001_gene223 6.56e-49 159.0 COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,1S4GX@1236|Gammaproteobacteria,1X7VH@135614|Xanthomonadales 135614|Xanthomonadales U Biopolymer transport protein ExbD/TolR - - - - - - - - - - - - ExbD k59_57443_2 998088.B565_3256 3e-37 131.0 COG0811@1|root,COG0811@2|Bacteria,1MX60@1224|Proteobacteria,1RRX1@1236|Gammaproteobacteria 1236|Gammaproteobacteria U COG0811 Biopolymer transport proteins - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_422153_1 1469245.JFBG01000032_gene1384 5.74e-74 234.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,1WX3F@135613|Chromatiales 135613|Chromatiales E Belongs to the peptidase M20A family. ArgE subfamily - - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_735497_1 1114959.SZMC14600_08268 1.42e-16 91.3 COG3209@1|root,COG3250@1|root,COG3534@1|root,COG3209@2|Bacteria,COG3250@2|Bacteria,COG3534@2|Bacteria,2I35N@201174|Actinobacteria,4EDQ6@85010|Pseudonocardiales 201174|Actinobacteria GKLMT LamG-like jellyroll fold domain - - - - - - - - - - - - Laminin_G_3 k59_996290_1 472759.Nhal_0796 5.89e-150 436.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1WWIC@135613|Chromatiales 135613|Chromatiales U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SDF k59_422155_1 926550.CLDAP_09030 3.3e-71 230.0 COG0263@1|root,COG0263@2|Bacteria,2G67X@200795|Chloroflexi 200795|Chloroflexi F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_684236_2 439235.Dalk_4426 8.49e-46 152.0 arCOG05626@1|root,32V4D@2|Bacteria,1NXWW@1224|Proteobacteria,430Y7@68525|delta/epsilon subdivisions,2WVX7@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_684236_3 411489.CLOL250_01278 2.72e-09 67.4 COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,36E6C@31979|Clostridiaceae 186801|Clostridia M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_369947_1 666681.M301_0145 4.86e-87 274.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KKZR@206350|Nitrosomonadales 206350|Nitrosomonadales NU General secretory system II protein E domain protein - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_1467096_1 1415780.JPOG01000001_gene2579 2.74e-37 144.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1X4DT@135614|Xanthomonadales 135614|Xanthomonadales G Na melibiose symporter and related transporters ynaJ - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_788731_2 1122194.AUHU01000002_gene2893 2.01e-26 103.0 2C4GG@1|root,331DQ@2|Bacteria,1N7QC@1224|Proteobacteria,1SCI3@1236|Gammaproteobacteria,468SZ@72275|Alteromonadaceae 1236|Gammaproteobacteria S Polyribonucleotide nucleotidyltransferase - - - - - - - - - - - - - k59_57453_2 754477.Q7C_2578 1.22e-13 70.1 COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Pfam MotA TolQ ExbB proton channel family - - - - - - - - - - - - MotA_ExbB k59_1362438_1 519989.ECTPHS_00225 2.1e-32 126.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1WW7J@135613|Chromatiales 135613|Chromatiales F Ribonucleotide reductase, barrel domain - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1309911_1 1229909.NSED_00615 2.47e-129 384.0 COG1001@1|root,arCOG00693@2157|Archaea,41SZH@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1 k59_892444_1 1296990.H845_2726 1.43e-05 46.6 COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2TTC7@28211|Alphaproteobacteria,2JP95@204441|Rhodospirillales 204441|Rhodospirillales M Belongs to the NAD(P)-dependent epimerase dehydratase family galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_108312_2 2002.JOEQ01000035_gene6723 3.06e-56 199.0 COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4EFSB@85012|Streptosporangiales 201174|Actinobacteria S MMPL family - - - ko:K06994 - - - - ko00000 - - - MMPL k59_1101347_1 338969.Rfer_3686 5.43e-10 57.8 COG3212@1|root,COG3212@2|Bacteria,1P88W@1224|Proteobacteria,2W6CA@28216|Betaproteobacteria,4AIXX@80864|Comamonadaceae 28216|Betaproteobacteria S Peptidase propeptide and YPEB domain - - - - - - - - - - - - PepSY k59_840071_1 1122603.ATVI01000007_gene1680 2.76e-41 149.0 COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1X2YI@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_840071_2 351348.Maqu_1728 5.26e-52 177.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,464HQ@72275|Alteromonadaceae 1236|Gammaproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 CBS,IMPDH,NMO k59_1309917_1 929556.Solca_3019 3.7e-11 59.7 COG0255@1|root,COG0255@2|Bacteria,4P9VV@976|Bacteroidetes,1IU24@117747|Sphingobacteriia 976|Bacteroidetes J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_1309917_2 1124780.ANNU01000035_gene234 5.32e-40 133.0 COG0186@1|root,COG0186@2|Bacteria,4NSB2@976|Bacteroidetes,47R6N@768503|Cytophagia 976|Bacteroidetes J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_996315_1 998674.ATTE01000001_gene3902 3.75e-109 334.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,462C5@72273|Thiotrichales 72273|Thiotrichales I PFAM AMP-binding enzyme - - - - - - - - - - - - AMP-binding k59_1362449_1 521003.COLINT_03786 8.78e-05 44.3 COG1040@1|root,COG1040@2|Bacteria,2HUUT@201174|Actinobacteria,4CVQ0@84998|Coriobacteriia 84998|Coriobacteriia S competence protein - - - - - - - - - - - - Pribosyltran k59_1362449_2 1379270.AUXF01000006_gene212 3.06e-39 140.0 COG0057@1|root,COG0057@2|Bacteria,1ZSTF@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain - - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_1414453_1 1254432.SCE1572_34815 2.96e-07 53.1 COG0421@1|root,COG4262@1|root,COG0421@2|Bacteria,COG4262@2|Bacteria,1QX9D@1224|Proteobacteria,42Q62@68525|delta/epsilon subdivisions,2WMHX@28221|Deltaproteobacteria,2YUT9@29|Myxococcales 28221|Deltaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_944155_1 1419583.V466_22555 5.34e-08 57.0 2DNWG@1|root,32ZIW@2|Bacteria,1RFKX@1224|Proteobacteria,1SDUB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Bacterial protein of unknown function (Gcw_chp) - - - - - - - - - - - - Gcw_chp k59_578830_3 234267.Acid_6121 2.24e-34 122.0 COG3436@1|root,COG3436@2|Bacteria,3Y875@57723|Acidobacteria 57723|Acidobacteria L IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_422180_1 557598.LHK_00546 3.34e-74 230.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2VIQF@28216|Betaproteobacteria,2KQJP@206351|Neisseriales 206351|Neisseriales M Belongs to the KdsA family kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_422180_2 196367.JNFG01000202_gene2498 3.57e-10 60.1 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,1K150@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_474115_1 1286093.C266_19315 6.35e-57 195.0 COG3946@1|root,COG3946@2|Bacteria,1R7R5@1224|Proteobacteria,2VNFU@28216|Betaproteobacteria,1K2AC@119060|Burkholderiaceae 28216|Betaproteobacteria U PFAM virulence factor family protein - - - - - - - - - - - - VirJ k59_429085_1 1089552.KI911559_gene2393 3.91e-57 181.0 COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2TSAM@28211|Alphaproteobacteria,2JQN7@204441|Rhodospirillales 204441|Rhodospirillales O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_429085_2 1499967.BAYZ01000016_gene6567 5.26e-87 268.0 COG1181@1|root,COG1181@2|Bacteria,2NPB2@2323|unclassified Bacteria 2|Bacteria M Belongs to the D-alanine--D-alanine ligase family ddl GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iAF1260.b0381,iB21_1397.B21_00332,iBWG_1329.BWG_0265,iE2348C_1286.E2348C_0317,iEC042_1314.EC042_0413,iEC55989_1330.EC55989_0386,iECBD_1354.ECBD_3283,iECB_1328.ECB_00328,iECDH10B_1368.ECDH10B_0338,iECDH1ME8569_1439.ECDH1ME8569_0367,iECD_1391.ECD_00328,iECH74115_1262.ECH74115_0453,iECIAI1_1343.ECIAI1_0377,iECIAI39_1322.ECIAI39_0301,iECO103_1326.ECO103_0356,iECO111_1330.ECO111_0411,iECO26_1355.ECO26_0414,iECSE_1348.ECSE_0401,iECSP_1301.ECSP_0441,iECs_1301.ECs0431,iETEC_1333.ETEC_0434,iEcDH1_1363.EcDH1_3227,iEcE24377_1341.EcE24377A_0406,iEcHS_1320.EcHS_A0447,iEcSMS35_1347.EcSMS35_0410,iEcolC_1368.EcolC_3251,iJO1366.b0381,iJR904.b0381,iSF_1195.SF0232,iSFxv_1172.SFxv_0245,iS_1188.S0254,iUMNK88_1353.UMNK88_429,iY75_1357.Y75_RS01965,iZ_1308.Z0477 Dala_Dala_lig_C,Dala_Dala_lig_N k59_482047_1 316058.RPB_2246 3.88e-08 60.8 COG2931@1|root,COG3210@1|root,COG3291@1|root,COG5625@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG5625@2|Bacteria,1MU7T@1224|Proteobacteria,2U1YP@28211|Alphaproteobacteria,3JRUE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - He_PIG,HemolysinCabind,VWA_2 k59_533235_1 1242864.D187_001504 1.13e-23 105.0 COG0840@1|root,COG4166@1|root,COG0840@2|Bacteria,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,43BXR@68525|delta/epsilon subdivisions,2X7IP@28221|Deltaproteobacteria 28221|Deltaproteobacteria ENT Bacterial extracellular solute-binding proteins, family 5 Middle - - - - - - - - - - - - MCPsignal,SBP_bac_5 k59_482048_1 395495.Lcho_3892 6.46e-110 343.0 COG3391@1|root,COG3391@2|Bacteria,1R7E0@1224|Proteobacteria,2W09X@28216|Betaproteobacteria,1KMW8@119065|unclassified Burkholderiales 28216|Betaproteobacteria S TIGRFAM 40-residue YVTN family beta-propeller repeat - - - - - - - - - - - - Cytochrom_D1 k59_1003120_1 795666.MW7_0119 4.09e-123 359.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria,1JZSS@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_220067_1 1229780.BN381_400017 1.34e-95 290.0 COG1960@1|root,COG1960@2|Bacteria,2GIXS@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1003125_1 1205680.CAKO01000037_gene1210 1.3e-37 137.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JR7C@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the aldehyde dehydrogenase family betB - - - - - - - - - - - Aldedh k59_1003125_2 305900.GV64_07955 5.21e-05 47.4 COG0730@1|root,COG0730@2|Bacteria 2|Bacteria S response to heat MA20_43555 - - ko:K07090 - - - - ko00000 - - - TauE k59_742188_2 411684.HPDFL43_02909 7.19e-31 120.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,43I48@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA,TctB k59_798068_1 216594.MMAR_0018 2.6e-07 57.4 COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria,235TI@1762|Mycobacteriaceae 201174|Actinobacteria M penicillin-binding protein pbpA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K05364 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01011 - - - Transpeptidase k59_66468_1 160492.XF_0049 9.59e-126 371.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1X43Q@135614|Xanthomonadales 135614|Xanthomonadales I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_66469_1 604331.AUHY01000046_gene1826 8.32e-35 136.0 COG1132@1|root,COG1132@2|Bacteria,1WIMR@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus V ABC-type multidrug transport system ATPase and permease - - - ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_1003126_1 1007105.PT7_3601 1.54e-72 243.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VIEX@28216|Betaproteobacteria,3T6YY@506|Alcaligenaceae 28216|Betaproteobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_66473_1 765913.ThidrDRAFT_3254 1.07e-90 288.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,1WWMA@135613|Chromatiales 135613|Chromatiales P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_585628_1 1454004.AW11_02113 2.48e-33 129.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2VM5U@28216|Betaproteobacteria 28216|Betaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_114941_1 1131266.ARWQ01000012_gene1612 3.29e-43 149.0 COG1013@1|root,arCOG01599@2157|Archaea,41SAB@651137|Thaumarchaeota 651137|Thaumarchaeota C Pyruvate ferredoxin oxidoreductase beta subunit C terminal - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_114941_2 1449063.JMLS01000018_gene5967 5.68e-30 124.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1TSSC@1239|Firmicutes,4HA8C@91061|Bacilli,26SWP@186822|Paenibacillaceae 91061|Bacilli C ferredoxin oxidoreductase korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1577664_1 436308.Nmar_1604 1.03e-63 206.0 COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota 651137|Thaumarchaeota K Phosphate uptake regulator - - - - - - - - - - - - MazE_antitoxin,PhoU k59_533258_1 748224.HMPREF9436_02146 4.84e-35 133.0 COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,3WGXA@541000|Ruminococcaceae 186801|Clostridia H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K01598,ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_66476_1 1216976.AX27061_2173 7.01e-16 80.1 COG1733@1|root,COG1733@2|Bacteria,1RIZT@1224|Proteobacteria,2VT1N@28216|Betaproteobacteria,3T4XN@506|Alcaligenaceae 28216|Betaproteobacteria K transcriptional - - - - - - - - - - - - HxlR k59_66476_2 232721.Ajs_3774 6.61e-06 52.4 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHT0@28216|Betaproteobacteria,4AB39@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_5082_1 1229909.NSED_09490 3.21e-145 421.0 COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM glutamine synthetase, type I - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_1369226_1 1380390.JIAT01000009_gene1091 4.59e-109 324.0 COG0179@1|root,COG0179@2|Bacteria,2GKED@201174|Actinobacteria 201174|Actinobacteria Q PFAM fumarylacetoacetate (FAA) hydrolase - - - - - - - - - - - - DUF2437,FAA_hydrolase k59_846947_1 1046625.AFQY01000007_gene112 1.42e-05 42.7 2A75J@1|root,30W1E@2|Bacteria,1QPMF@1224|Proteobacteria,1TNC0@1236|Gammaproteobacteria,3NQBH@468|Moraxellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_742207_1 502025.Hoch_4120 2.45e-36 135.0 COG1075@1|root,COG1075@2|Bacteria,1Q6AV@1224|Proteobacteria,432RP@68525|delta/epsilon subdivisions 1224|Proteobacteria S PGAP1-like protein - - 3.1.1.3 ko:K01046 ko00561,ko01100,map00561,map01100 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000 - - - PGAP1 k59_114947_1 1211115.ALIQ01000198_gene463 1.59e-34 129.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,3NAJC@45404|Beijerinckiaceae 28211|Alphaproteobacteria CE Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_114947_2 216142.LT40_15505 3.84e-05 44.7 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria 1224|Proteobacteria CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate yeaU - 1.1.1.83,1.1.1.85,1.1.1.93,4.1.1.73 ko:K00052,ko:K07246 ko00290,ko00630,ko00650,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00630,map00650,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00215,R00994,R01751,R02545,R04426,R06180,R10052 RC00084,RC00105,RC00417,RC00594,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_482091_1 880072.Desac_0027 1.38e-27 117.0 COG0739@1|root,COG0739@2|Bacteria,1NESH@1224|Proteobacteria,42MGB@68525|delta/epsilon subdivisions,2WJ7F@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Peptidase M23 - - - - - - - - - - - - Peptidase_M23 k59_1215171_1 1304885.AUEY01000023_gene2677 1.35e-71 232.0 COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,42MU3@68525|delta/epsilon subdivisions,2WKTF@28221|Deltaproteobacteria,2MNAQ@213118|Desulfobacterales 28221|Deltaproteobacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH k59_1215172_1 1211819.CALK01000053_gene1055 1.36e-05 46.6 COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,3VPDK@526524|Erysipelotrichia 526524|Erysipelotrichia E Psort location Cytoplasmic, score 8.87 aroF - - - - - - - - - - - DAHP_synth_1 k59_1215172_2 926561.KB900621_gene2787 4.33e-50 164.0 COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,249JC@186801|Clostridia,3WAJR@53433|Halanaerobiales 186801|Clostridia F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS04225 Formyl_trans_N k59_1422240_1 472759.Nhal_2489 7.51e-119 359.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1X0IP@135613|Chromatiales 135613|Chromatiales G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position - - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_114951_1 1123236.KB899387_gene1928 3.93e-68 227.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,464Q0@72275|Alteromonadaceae 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - iECNA114_1301.ECNA114_3794,iECOK1_1307.ECOK1_4092,iECP_1309.ECP_3748,iECS88_1305.ECS88_4065,iECSF_1327.ECSF_3486,iLF82_1304.LF82_2165,iNRG857_1313.NRG857_18145,iUMN146_1321.UM146_18405,iUTI89_1310.UTI89_C4195,ic_1306.c4475 ACT_4,HD_4,RelA_SpoT,TGS k59_846952_1 1313172.YM304_32890 4.28e-70 226.0 COG1218@1|root,COG1218@2|Bacteria 2|Bacteria P 3'(2'),5'-bisphosphate nucleotidase activity cysQ - 3.1.3.25,3.1.3.7 ko:K01082,ko:K01092 ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070 M00131 R00188,R00508,R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000,ko03016 - - - Inositol_P k59_1422245_1 68199.JNZO01000015_gene3483 3.44e-26 103.0 COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1422245_2 396588.Tgr7_2114 4.19e-29 119.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales 135613|Chromatiales Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_692048_1 592316.Pat9b_0004 3.22e-64 216.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,3VXUK@53335|Pantoea 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1316422_1 266117.Rxyl_0919 6.32e-57 193.0 COG1144@1|root,COG1144@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor porD GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575 1.2.7.1,1.2.7.10 ko:K00171,ko:K00172,ko:K19072 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_10,Fer4_21,POR k59_1316422_2 266117.Rxyl_0920 1.89e-177 508.0 COG0674@1|root,COG0674@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor porA GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575 1.2.7.1,1.2.7.10 ko:K00169,ko:K19070 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N k59_1316422_3 266117.Rxyl_0921 1.89e-62 203.0 COG1013@1|root,COG1013@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor - GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575 1.2.7.1,1.2.7.10 ko:K00170,ko:K19071 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_1267813_1 1380394.JADL01000016_gene411 3.63e-31 121.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2JQPR@204441|Rhodospirillales 204441|Rhodospirillales EQ Hydantoinase/oxoprolinase N-terminal region - - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_1267813_2 1283300.ATXB01000002_gene3045 6.38e-80 245.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1S2WI@1236|Gammaproteobacteria,1XEYK@135618|Methylococcales 135618|Methylococcales O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_1215190_1 1485544.JQKP01000020_gene55 8.39e-31 116.0 COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2VJUN@28216|Betaproteobacteria,44V8V@713636|Nitrosomonadales 28216|Betaproteobacteria M Nucleotidyl transferase rmlA - 2.7.7.99 ko:K00992 ko00520,ko01100,map00520,map01100 - R11025 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_1215190_2 585.DR95_3445 1.13e-36 133.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,3Z0ZV@583|Proteus 1236|Gammaproteobacteria H Catalyzes the ferrous insertion into protoporphyrin IX hemH GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009314,GO:0009416,GO:0009628,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1540,iECS88_1305.ECS88_0472,iEcE24377_1341.EcE24377A_0515 Ferrochelatase k59_692054_2 396588.Tgr7_2778 2e-42 154.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales 135613|Chromatiales C FAD linked - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_1316427_1 1239962.C943_00730 7.19e-25 103.0 COG4147@1|root,COG4147@2|Bacteria,4NHPT@976|Bacteroidetes,47JSK@768503|Cytophagia 976|Bacteroidetes S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_1475860_1 1232410.KI421425_gene1552 5.03e-74 249.0 COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales 28221|Deltaproteobacteria M OmpA family - - - - - - - - - - - - OmpA k59_114966_2 391625.PPSIR1_24364 3.96e-29 115.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2WIYY@28221|Deltaproteobacteria,2YWP3@29|Myxococcales 28221|Deltaproteobacteria S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1475868_1 1521187.JPIM01000097_gene2709 9.98e-36 141.0 COG3119@1|root,COG3379@1|root,COG3119@2|Bacteria,COG3379@2|Bacteria,2G90N@200795|Chloroflexi,376SX@32061|Chloroflexia 32061|Chloroflexia P Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_846972_1 1229909.NSED_05835 1.95e-58 198.0 arCOG08716@1|root,arCOG10358@1|root,arCOG08716@2157|Archaea,arCOG10358@2157|Archaea,41SYI@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_641104_1 533240.CRC_00111 2.3e-68 221.0 COG0065@1|root,COG0065@2|Bacteria,1G1J0@1117|Cyanobacteria,1HIRX@1161|Nostocales 1117|Cyanobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_641104_2 118161.KB235922_gene2273 6.82e-66 208.0 COG0066@1|root,COG0066@2|Bacteria,1G2Y2@1117|Cyanobacteria,3VHX9@52604|Pleurocapsales 1117|Cyanobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_1056120_1 754477.Q7C_2503 1.83e-31 122.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,460N2@72273|Thiotrichales 72273|Thiotrichales S Permease YjgP YjgQ lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_114978_1 1198452.Jab_1c08190 1.33e-59 199.0 COG2199@1|root,COG3159@1|root,COG3159@2|Bacteria,COG3706@2|Bacteria,1R8F2@1224|Proteobacteria,2VJGD@28216|Betaproteobacteria,472P5@75682|Oxalobacteraceae 28216|Betaproteobacteria T Protein of unknown function, DUF484 - - - - - - - - - - - - DUF484,GGDEF k59_1056121_1 909663.KI867150_gene333 9.69e-34 132.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MQB9@213462|Syntrophobacterales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane - - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SecA_DEAD,SecA_PP_bind k59_220138_1 215803.DB30_0494 3.35e-20 94.7 COG1361@1|root,COG1572@1|root,COG1361@2|Bacteria,COG1572@2|Bacteria,1QX45@1224|Proteobacteria,42YA1@68525|delta/epsilon subdivisions,2WTP9@28221|Deltaproteobacteria,2YWVC@29|Myxococcales 28221|Deltaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - HYR,Kelch_4,VCBS k59_950880_1 330214.NIDE0563 2.43e-97 298.0 COG1032@1|root,COG1032@2|Bacteria,3J0WM@40117|Nitrospirae 40117|Nitrospirae C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_641113_1 566466.NOR53_1180 7.89e-54 183.0 COG0624@1|root,COG0624@2|Bacteria,1R96A@1224|Proteobacteria,1RSD6@1236|Gammaproteobacteria,1J8ZH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_1630795_1 1280.SAXN108_1721 5.68e-109 327.0 COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,4H9YE@91061|Bacilli,4GWXT@90964|Staphylococcaceae 91061|Bacilli C Belongs to the citrate synthase family citZ - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_1630795_2 314285.KT71_02682 1.11e-46 164.0 COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,1T3IW@1236|Gammaproteobacteria,1J8JS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1 k59_1159699_1 1382359.JIAL01000001_gene1992 7.94e-86 270.0 COG0166@1|root,COG0166@2|Bacteria,3Y3HG@57723|Acidobacteria,2JIQE@204432|Acidobacteriia 204432|Acidobacteriia G Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_1522319_1 349741.Amuc_1938 7.06e-28 108.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,46URE@74201|Verrucomicrobia,2ITXE@203494|Verrucomicrobiae 203494|Verrucomicrobiae L Helix-hairpin-helix class 2 (Pol1 family) motifs - - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1522319_2 1280947.HY30_08290 4.42e-116 360.0 COG2871@1|root,COG3182@1|root,COG2871@2|Bacteria,COG3182@2|Bacteria,1R69Z@1224|Proteobacteria,2U520@28211|Alphaproteobacteria,440YM@69657|Hyphomonadaceae 28211|Alphaproteobacteria C Peptidase propeptide and YPEB domain - - - - - - - - - - - - FAD_binding_6,Fer2,NAD_binding_1,PepSY,PepSY_TM k59_641116_1 626887.J057_23620 1.75e-60 209.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,465GZ@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD k59_272555_1 1304888.ATWF01000001_gene1132 1.69e-56 192.0 COG1190@1|root,COG1190@2|Bacteria,2GEUY@200930|Deferribacteres 200930|Deferribacteres J tRNA synthetases class II (D, K and N) lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_1108377_1 883126.HMPREF9710_04347 6.07e-43 148.0 COG0204@1|root,COG0204@2|Bacteria,1RJMS@1224|Proteobacteria,2VPJM@28216|Betaproteobacteria,474K7@75682|Oxalobacteraceae 28216|Betaproteobacteria I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase k59_1056132_1 713587.THITH_02400 2.92e-45 162.0 COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,1RRIA@1236|Gammaproteobacteria,1X0CC@135613|Chromatiales 135613|Chromatiales E 7 transmembrane helices usually fused to an inactive transglutaminase - - - - - - - - - - - - 7TM_transglut,Transglut_i_TM k59_1630800_1 395963.Bind_3399 4.1e-07 50.8 COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,2U70U@28211|Alphaproteobacteria,3NBJJ@45404|Beijerinckiaceae 28211|Alphaproteobacteria P ArsC family arsC - 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC k59_742262_1 396588.Tgr7_1857 3.56e-19 87.8 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WXY0@135613|Chromatiales 135613|Chromatiales P Sulfate transporter antisigma-factor antagonist STAS - - - - - - - - - - - - STAS,Sulfate_transp k59_1108381_1 234267.Acid_4491 1.54e-66 228.0 COG0653@1|root,COG0653@2|Bacteria,3Y34P@57723|Acidobacteria 57723|Acidobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_641126_1 224324.aq_1412 7.05e-33 127.0 COG1574@1|root,COG1574@2|Bacteria 2|Bacteria G metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_585697_1 1229909.NSED_06960 2.23e-05 49.7 arCOG08716@1|root,arCOG08716@2157|Archaea 1229909.NSED_06960|- - - - - - - - - - - - - - - - k59_899465_1 1265502.KB905934_gene3292 3.78e-100 320.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,4AC69@80864|Comamonadaceae 28216|Betaproteobacteria EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_325280_1 1229909.NSED_08150 1.15e-97 289.0 COG0311@1|root,arCOG00034@2157|Archaea,41SIZ@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS pdxT - 4.3.3.6 ko:K08681 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SNO k59_846997_1 94624.Bpet4321 4.05e-23 98.2 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2VJN2@28216|Betaproteobacteria,3T1QF@506|Alcaligenaceae 28216|Betaproteobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_115004_1 1121921.KB898712_gene2124 7.09e-31 125.0 COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,2PN4G@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria U COG0823 Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - PD40 k59_534005_1 644282.Deba_2993 5.19e-63 216.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1321144_1 270374.MELB17_05067 2.4e-82 264.0 COG4176@1|root,COG4176@2|Bacteria,1MUM4@1224|Proteobacteria,1SK88@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02001 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1 k59_490567_1 1249627.D779_1804 1.75e-154 444.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1WW0I@135613|Chromatiales 135613|Chromatiales E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_490567_2 1123517.JOMR01000001_gene906 2.97e-13 65.9 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria,460JM@72273|Thiotrichales 72273|Thiotrichales K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_171824_1 933262.AXAM01000015_gene82 4.18e-84 271.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2WJ2W@28221|Deltaproteobacteria,2MHMB@213118|Desulfobacterales 28221|Deltaproteobacteria O ATP-dependent Clp protease ATP-binding subunit ClpA clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_539463_1 404589.Anae109_4145 1.09e-53 178.0 COG0204@1|root,COG0204@2|Bacteria,1R9IG@1224|Proteobacteria,42T29@68525|delta/epsilon subdivisions,2WPJ8@28221|Deltaproteobacteria,2YUTC@29|Myxococcales 28221|Deltaproteobacteria I Acyltransferase - - - - - - - - - - - - Acyltransferase k59_435817_1 1267005.KB911265_gene3608 4.78e-99 306.0 COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2TUPJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_1375424_1 1469607.KK073768_gene3672 9.42e-62 210.0 COG1834@1|root,COG1915@1|root,COG1834@2|Bacteria,COG1915@2|Bacteria,1G2AU@1117|Cyanobacteria,1HK7P@1161|Nostocales 1117|Cyanobacteria E PFAM LOR SDH bifunctional enzyme conserved region - - - - - - - - - - - - Amidinotransf,Saccharop_dh_N k59_122952_2 909663.KI867150_gene1145 3.54e-87 283.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WISW@28221|Deltaproteobacteria,2MQA5@213462|Syntrophobacterales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_279139_1 391612.CY0110_07414 5.45e-98 333.0 COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,3KHM6@43988|Cyanothece 1117|Cyanobacteria Q PFAM AMP-dependent synthetase and ligase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,TauD,Thioesterase k59_1276361_1 1510531.JQJJ01000012_gene1462 1.32e-55 189.0 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2TR9C@28211|Alphaproteobacteria,3JRDN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E amino acid ABC - - - ko:K09971 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_279140_1 584708.Apau_0927 1.28e-45 166.0 COG0209@1|root,COG0209@2|Bacteria,3TAE6@508458|Synergistetes 508458|Synergistetes F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_279140_2 1247649.D560_0129 1.69e-23 98.6 COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,2VQP5@28216|Betaproteobacteria 28216|Betaproteobacteria I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydratas k59_1062761_2 714083.JH370377_gene1644 2.7e-19 83.6 COG0691@1|root,COG0691@2|Bacteria,2GJX1@201174|Actinobacteria,4FNEQ@85023|Microbacteriaceae 201174|Actinobacteria O Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene smpB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03664 - - - - ko00000 - - - SmpB k59_385251_2 1121878.AUGL01000001_gene484 2.94e-06 49.3 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,1RNKH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria yibQ - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_74776_1 1229909.NSED_04350 9.21e-40 146.0 COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota 651137|Thaumarchaeota T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,dCache_1 k59_853403_1 215803.DB30_8139 3.8e-71 226.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,2YTXP@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_853403_2 1288494.EBAPG3_11630 1.16e-113 340.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2VH57@28216|Betaproteobacteria,371NP@32003|Nitrosomonadales 28216|Betaproteobacteria F May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_1526677_1 266264.Rmet_2874 8.34e-42 149.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2VH6N@28216|Betaproteobacteria,1K1GJ@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_1526677_2 357809.Cphy_2432 7.09e-24 106.0 COG2866@1|root,COG2866@2|Bacteria,1V09S@1239|Firmicutes 1239|Firmicutes E Protein of unknown function (DUF2817) - - - - - - - - - - - - DUF2817 k59_649443_1 1415779.JOMH01000001_gene1499 3.77e-31 120.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,1X3A4@135614|Xanthomonadales 135614|Xanthomonadales M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_649443_2 349124.Hhal_1007 3.59e-55 178.0 COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,1WYH2@135613|Chromatiales 135613|Chromatiales M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins - - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD k59_649443_3 1120953.AUBH01000001_gene1283 1.8e-41 155.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,464KX@72275|Alteromonadaceae 1236|Gammaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604 PBP_dimer,Transpeptidase k59_385268_1 344747.PM8797T_11621 7.53e-142 411.0 COG0076@1|root,COG0076@2|Bacteria,2J2HP@203682|Planctomycetes 203682|Planctomycetes H Belongs to the group II decarboxylase family - - 4.1.1.15 ko:K01580 ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940 M00027 R00261,R00489,R01682,R02466 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Pyridoxal_deC k59_1484189_1 1232410.KI421422_gene2035 2.79e-45 161.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,42MA0@68525|delta/epsilon subdivisions,2WJAT@28221|Deltaproteobacteria,43RXU@69541|Desulfuromonadales 28221|Deltaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_853411_1 435908.IDSA_08305 2.05e-61 212.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2QEXG@267893|Idiomarinaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrF - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_853411_2 631362.Thi970DRAFT_02773 3.4e-10 60.8 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1WWA8@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_905872_1 436308.Nmar_0045 2.52e-54 172.0 arCOG10514@1|root,arCOG10514@2157|Archaea,41STR@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_905872_2 1229909.NSED_09850 2.85e-23 91.3 arCOG08817@1|root,arCOG08817@2157|Archaea,41SV5@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1484197_1 998674.ATTE01000001_gene2939 1.17e-41 151.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,1RZYP@1236|Gammaproteobacteria,461UJ@72273|Thiotrichales 72273|Thiotrichales P Domain of unknown function DUF21 - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_171855_2 1219035.NT2_07_01960 1.42e-29 127.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U3JH@28211|Alphaproteobacteria,2K1GK@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1276407_1 222534.KB893672_gene2974 5.19e-13 73.6 28MCN@1|root,2ZAQR@2|Bacteria,2GXXM@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_539504_1 519989.ECTPHS_02516 1.58e-43 159.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1WWAT@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_1484198_1 667632.KB890219_gene685 2.27e-10 67.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,1JZZ1@119060|Burkholderiaceae 28216|Betaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_385292_1 1201293.AKXQ01000003_gene2490 3.67e-50 180.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18989 - M00720 - - ko00000,ko00002,ko02000 2.A.6.2.30 - - ACR_tran k59_1221917_2 314278.NB231_02178 4.44e-10 61.2 COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,1SA9N@1236|Gammaproteobacteria,1WYMN@135613|Chromatiales 135613|Chromatiales I PFAM thioesterase superfamily - - - ko:K10806 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT k59_226446_2 56780.SYN_01492 1.01e-55 190.0 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,42PA6@68525|delta/epsilon subdivisions,2WIIY@28221|Deltaproteobacteria,2MQ7T@213462|Syntrophobacterales 28221|Deltaproteobacteria U Type II and III secretion system protein - - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - BON,Secretin,T2SS-T3SS_pil_N k59_806586_1 985053.VMUT_1064 4.82e-09 65.5 COG3119@1|root,arCOG02787@2157|Archaea,2XS3H@28889|Crenarchaeota 28889|Crenarchaeota P Sulfatase - - - - - - - - - - - - Sulfatase k59_1062809_1 269796.Rru_A2736 1.08e-45 169.0 COG0500@1|root,COG4641@1|root,COG2226@2|Bacteria,COG4641@2|Bacteria,1PEWV@1224|Proteobacteria,2VCW4@28211|Alphaproteobacteria,2JY0N@204441|Rhodospirillales 204441|Rhodospirillales Q Methyltransferase domain - - - - - - - - - - - - - k59_1430521_1 502025.Hoch_2201 1.33e-55 176.0 COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2YV2V@29|Myxococcales 28221|Deltaproteobacteria C Rubrerythrin rbr GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - - - - - - - - - - Rubrerythrin k59_1430521_2 395493.BegalDRAFT_2790 5.85e-16 79.3 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,4620M@72273|Thiotrichales 72273|Thiotrichales C Cysteine-rich domain - - - - - - - - - - - - CCG k59_853445_1 1280698.AUJS01000121_gene1703 5.33e-10 63.5 COG4467@1|root,COG4467@2|Bacteria,1UK82@1239|Firmicutes,25FQ4@186801|Clostridia 186801|Clostridia S Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66 k59_1276437_1 2002.JOEQ01000036_gene671 2.26e-66 207.0 28NTV@1|root,2ZBSB@2|Bacteria,2GS03@201174|Actinobacteria,4EMSC@85012|Streptosporangiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1221932_1 1207063.P24_04190 1.54e-74 242.0 COG0700@1|root,COG2715@1|root,COG0700@2|Bacteria,COG2715@2|Bacteria,1MVZ0@1224|Proteobacteria,2TUZJ@28211|Alphaproteobacteria,2JQYS@204441|Rhodospirillales 204441|Rhodospirillales S membrane protein, required for spore maturation in B.subtilis - - - - - - - - - - - - Gate k59_1009741_1 215803.DB30_0746 4.47e-42 151.0 COG3804@1|root,COG3804@2|Bacteria,1N3H7@1224|Proteobacteria,433QN@68525|delta/epsilon subdivisions,2WYE0@28221|Deltaproteobacteria,2YYGE@29|Myxococcales 28221|Deltaproteobacteria C Dihydrodipicolinate reductase, N-terminus - - 1.4.1.12,1.4.1.26 ko:K21672 ko00310,ko00330,ko00472,map00310,map00330,map00472 - R02825,R04200,R04201,R04687,R04688 RC00249,RC00790 ko00000,ko00001,ko01000 - - - DapB_N k59_698517_1 269799.Gmet_2301 1.11e-06 57.4 COG3005@1|root,COG3005@2|Bacteria,1NJY9@1224|Proteobacteria,42XJ4@68525|delta/epsilon subdivisions,2WSQ4@28221|Deltaproteobacteria,43TRS@69541|Desulfuromonadales 28221|Deltaproteobacteria C heme-binding sites - - - - - - - - - - - - Cytochrome_C7 k59_331642_1 1469245.JFBG01000027_gene1482 3.56e-75 243.0 COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,1RMC2@1236|Gammaproteobacteria,1WVZ5@135613|Chromatiales 135613|Chromatiales F Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation aceK - 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK k59_332482_2 1121106.JQKB01000002_gene3381 1.14e-58 187.0 COG0625@1|root,COG0625@2|Bacteria,1Q05U@1224|Proteobacteria,2TTDK@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Glutathione S-transferase - - - - - - - - - - - - GST_C,GST_C_2,GST_N,GST_N_3 k59_1223012_1 1121904.ARBP01000007_gene3005 1.21e-06 55.8 COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3391@1|root,COG3420@1|root,COG4733@1|root,COG4886@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,COG3420@2|Bacteria,COG4733@2|Bacteria,COG4886@2|Bacteria,4PHVF@976|Bacteroidetes,47SD5@768503|Cytophagia 976|Bacteroidetes P Leucine rich repeat - - - - - - - - - - - - LRR_8,Laminin_G_3,VCBS k59_957933_2 1121406.JAEX01000002_gene1118 1.53e-159 468.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria,2M8VR@213115|Desulfovibrionales 28221|Deltaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_540330_1 1041159.AZUW01000015_gene336 6.08e-53 189.0 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,4B81Q@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_8317_1 105559.Nwat_1090 3.08e-114 361.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales 135613|Chromatiales E Vitamin B12 dependent methionine synthase activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_854305_1 880073.Calab_2776 6.14e-19 93.6 COG0358@1|root,COG0358@2|Bacteria,2NNNJ@2323|unclassified Bacteria 2|Bacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_540338_1 472759.Nhal_3928 2.05e-68 217.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1WXFU@135613|Chromatiales 135613|Chromatiales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_592908_1 1121035.AUCH01000004_gene429 9.63e-212 637.0 COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria 1224|Proteobacteria I CoA-substrate-specific enzyme activase - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_1431657_1 926569.ANT_31290 6.58e-21 102.0 COG0739@1|root,COG3103@1|root,COG0739@2|Bacteria,COG4991@2|Bacteria 2|Bacteria T sh3 domain protein - - 3.2.1.96 ko:K01227,ko:K03642 ko00511,map00511 - - - ko00000,ko00001,ko01000 - - - Glucosaminidase,NLPC_P60,Peptidase_M23,SH3_3,SLH k59_807736_1 1469245.JFBG01000020_gene1082 1.4e-111 332.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_807736_2 1123392.AQWL01000001_gene1553 3.98e-25 95.9 COG5007@1|root,COG5007@2|Bacteria,1MZCZ@1224|Proteobacteria,2VU0K@28216|Betaproteobacteria,1KTA1@119069|Hydrogenophilales 119069|Hydrogenophilales K BolA-like protein - - - - - - - - - - - - BolA k59_807736_3 59196.RICGR_0027 1.36e-10 59.7 COG3113@1|root,COG3113@2|Bacteria,1NGIE@1224|Proteobacteria,1SGH6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S NTP binding protein (Contains STAS domain) yrbB - - ko:K07122 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - STAS_2 k59_75982_1 160492.XF_1078 5.02e-27 115.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1X47B@135614|Xanthomonadales 135614|Xanthomonadales S DNA internalization-related competence protein ComEC Rec2 comA - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_1638275_1 95619.PM1_0226545 2.32e-24 108.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_1376308_1 706587.Desti_4441 4.43e-51 170.0 COG0730@1|root,COG0730@2|Bacteria,1NJ47@1224|Proteobacteria,42P2D@68525|delta/epsilon subdivisions,2WMG7@28221|Deltaproteobacteria 28221|Deltaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_1010621_1 1205680.CAKO01000002_gene3047 3.7e-55 183.0 COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,2TTSG@28211|Alphaproteobacteria,2JWR8@204441|Rhodospirillales 204441|Rhodospirillales S beta-lactamase - - - - - - - - - - - - - k59_1277617_1 1242864.D187_006591 3.86e-31 115.0 COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,42SQQ@68525|delta/epsilon subdivisions,2WPIW@28221|Deltaproteobacteria,2YVEU@29|Myxococcales 28221|Deltaproteobacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl k59_1010633_1 378806.STAUR_8346 6.69e-06 48.5 COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X4XD@28221|Deltaproteobacteria,2YZSN@29|Myxococcales 28221|Deltaproteobacteria KT Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF_2,HTH_8,Sigma54_activat k59_807775_1 156889.Mmc1_3436 4.81e-64 211.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2TRPX@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_540381_1 909613.UO65_3687 3.17e-49 173.0 COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4DXRB@85010|Pseudonocardiales 201174|Actinobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - HHH_5,IMS,IMS_C,IMS_HHH k59_860412_1 292.DM42_948 8.47e-11 65.9 COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1QTZD@1224|Proteobacteria,2VPU0@28216|Betaproteobacteria,1K7DE@119060|Burkholderiaceae 28216|Betaproteobacteria M Glycosyltransferase like family 2 - - - ko:K07011 - - - - ko00000 - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2 k59_1531843_1 314285.KT71_02682 2.21e-76 242.0 COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,1T3IW@1236|Gammaproteobacteria,1J8JS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1 k59_84014_1 876269.ARWA01000001_gene209 4.17e-94 288.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria 28211|Alphaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_1285822_1 1123368.AUIS01000003_gene1635 1.51e-45 149.0 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,2ND1V@225057|Acidithiobacillales 225057|Acidithiobacillales C Belongs to the glutaredoxin family. Monothiol subfamily - - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin k59_1439610_1 436308.Nmar_1254 4.15e-29 107.0 COG1632@1|root,arCOG04209@2157|Archaea,41SND@651137|Thaumarchaeota 651137|Thaumarchaeota J Ribosomal protein L15E - - - ko:K02877 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L15e k59_1439610_2 1229909.NSED_07025 5.63e-30 112.0 arCOG08768@1|root,arCOG08768@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_598875_1 1211114.ALIP01000156_gene2990 7.74e-38 147.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1X341@135614|Xanthomonadales 135614|Xanthomonadales Q ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_1016677_1 28115.HR11_09720 1.36e-40 140.0 COG0245@1|root,COG0245@2|Bacteria,4NP0N@976|Bacteroidetes,2FNVA@200643|Bacteroidia,22XNK@171551|Porphyromonadaceae 976|Bacteroidetes I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 4.6.1.12 ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - YgbB k59_1016677_2 1121448.DGI_3398 2.57e-13 69.3 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria,2M7T1@213115|Desulfovibrionales 28221|Deltaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_1285834_1 756272.Plabr_0133 1.79e-11 70.1 COG0457@1|root,COG0500@1|root,COG0859@1|root,COG1215@1|root,COG0457@2|Bacteria,COG0500@2|Bacteria,COG0859@2|Bacteria,COG1215@2|Bacteria,2IYBQ@203682|Planctomycetes 203682|Planctomycetes M Tetratricopeptide repeat - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 k59_1439629_2 1125863.JAFN01000001_gene3251 3.86e-60 190.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,42U6P@68525|delta/epsilon subdivisions,2WQ00@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM HNH endonuclease - - - - - - - - - - - - HNH_5 k59_443870_1 1089549.AZUQ01000001_gene1363 3.65e-64 214.0 COG3004@1|root,COG3004@2|Bacteria,2GKIK@201174|Actinobacteria,4EZ99@85014|Glycomycetales 201174|Actinobacteria P Na+/H+ antiporter 1 nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_1016678_1 1469245.JFBG01000080_gene276 3.36e-190 544.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1WWHU@135613|Chromatiales 135613|Chromatiales C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_912869_1 765911.Thivi_2324 5.14e-44 160.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1WWDS@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_84040_1 323261.Noc_0111 0.0 1089.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales 135613|Chromatiales C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1170058_2 323261.Noc_0612 1.6e-10 60.8 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1WWPS@135613|Chromatiales 135613|Chromatiales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_658826_1 1449068.JMLQ01000008_gene4055 1.31e-08 56.6 COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,4FVR1@85025|Nocardiaceae 201174|Actinobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv3708c Semialdhyde_dh,Semialdhyde_dhC k59_658826_2 519989.ECTPHS_11105 1.14e-32 122.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1WVY0@135613|Chromatiales 135613|Chromatiales CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_233049_1 87626.PTD2_13054 5.01e-23 98.2 COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,2Q0VY@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs truD GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_233049_2 545264.KB898751_gene2625 9.52e-20 84.7 COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0019954,GO:0022402,GO:0022414,GO:0030428,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044464,GO:0051301 - ko:K05589 - - - - ko00000,ko03036 - - - DivIC k59_860466_2 2340.JV46_25320 1.36e-05 50.4 COG4795@1|root,COG4795@2|Bacteria,1QIXC@1224|Proteobacteria,1TGTT@1236|Gammaproteobacteria,1JBCK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U General secretion pathway protein - - - - - - - - - - - - - k59_443897_1 1123054.KB907727_gene3066 2.32e-103 309.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,1WW91@135613|Chromatiales 135613|Chromatiales D TIGRFAM Cell shape determining protein MreB Mrl - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_233853_2 1144932.ATTF01000010_gene532 2.56e-15 75.9 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,4BPJT@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_816990_1 1203076.CAKF01000012_gene1121 3.03e-21 96.7 COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,4HA6A@91061|Bacilli,3F3YC@33958|Lactobacillaceae 91061|Bacilli U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_706008_1 95619.PM1_0228840 4.96e-39 141.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria 1236|Gammaproteobacteria C protein containing LysM domain lysM - - - - - - - - - - - LysM k59_501115_1 1469245.JFBG01000063_gene2336 1.76e-55 192.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1WXN6@135613|Chromatiales 135613|Chromatiales J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_85211_1 926556.Echvi_0555 1.52e-05 46.2 COG3264@1|root,COG3264@2|Bacteria,4NEAM@976|Bacteroidetes,47KYP@768503|Cytophagia 976|Bacteroidetes M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_85211_2 857087.Metme_2191 2.01e-48 159.0 COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,1S9D9@1236|Gammaproteobacteria,1XFA7@135618|Methylococcales 135618|Methylococcales FG HIT domain - - - - - - - - - - - - HIT k59_861318_1 1125700.HMPREF9195_01267 4.41e-31 118.0 COG0601@1|root,COG0601@2|Bacteria,2J601@203691|Spirochaetes 203691|Spirochaetes P ABC transporter, permease protein oppB - - ko:K02033,ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 k59_861318_2 1123261.AXDW01000034_gene2115 1.78e-25 106.0 COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria,1X48I@135614|Xanthomonadales 135614|Xanthomonadales E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 k59_1287049_1 323848.Nmul_A2449 9.57e-33 129.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria,371PH@32003|Nitrosomonadales 28216|Betaproteobacteria M Soluble lytic murein transglycosylase L domain slt - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_444940_1 652103.Rpdx1_2982 9.34e-80 257.0 COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria,1QT50@1224|Proteobacteria,2TTND@28211|Alphaproteobacteria,3JW9V@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L TOPRIM - - 3.6.4.12 ko:K17680 - - - - ko00000,ko01000,ko03029 - - - AAA_25,DnaB_C,Toprim_2,Toprim_4 k59_444940_2 268748.I3RYR4_BPPRP 2.14e-13 69.7 4QNER@10744|Podoviridae 10744|Podoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - - - - - - - - - - - k59_11698_2 436308.Nmar_1051 1.33e-37 134.0 arCOG10557@1|root,arCOG10557@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_659968_1 550540.Fbal_3593 0.00014 43.9 COG1145@1|root,COG1145@2|Bacteria,1MWHY@1224|Proteobacteria,1RZ4B@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - - - - - - - - - - Fer4,Fer4_10,Fer4_7 k59_659968_2 1123401.JHYQ01000007_gene544 8.54e-60 193.0 COG3381@1|root,COG3381@2|Bacteria,1MWWM@1224|Proteobacteria,1S449@1236|Gammaproteobacteria,462Q6@72273|Thiotrichales 72273|Thiotrichales S Nitrate reductase delta subunit - - - - - - - - - - - - Nitrate_red_del k59_1231376_1 314287.GB2207_07537 1.35e-151 449.0 COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,1J4JG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG1884 Methylmalonyl-CoA mutase, N-terminal domain subunit scpA GO:0003674,GO:0003824,GO:0004494,GO:0005488,GO:0008144,GO:0016853,GO:0016866,GO:0019842,GO:0031419,GO:0036094,GO:0046906,GO:0048037,GO:0097159,GO:1901363 5.4.99.2 ko:K01847,ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_3653,iECO26_1355.ECO26_4004 B12-binding,MM_CoA_mutase k59_339235_1 395493.BegalDRAFT_1528 1.55e-95 293.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,4605B@72273|Thiotrichales 72273|Thiotrichales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_11700_1 997830.HMPREF1124_1099 1.36e-34 134.0 COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,4HA60@91061|Bacilli,43FE9@68892|Streptococcus infantis 91061|Bacilli H Involved in the biosynthesis of porphyrin-containing compound hemN GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_1494523_1 313624.NSP_19220 1.79e-77 253.0 COG2132@1|root,COG2132@2|Bacteria,1G2BC@1117|Cyanobacteria,1HNMW@1161|Nostocales 1117|Cyanobacteria Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_546892_1 1120950.KB892762_gene5508 2.93e-32 119.0 COG4274@1|root,COG4274@2|Bacteria,2HWQ8@201174|Actinobacteria,4DW30@85009|Propionibacteriales 201174|Actinobacteria S GYD domain - - - - - - - - - - - - GYD k59_339243_1 1499967.BAYZ01000069_gene1895 5.59e-25 95.5 COG2442@1|root,COG2442@2|Bacteria 2|Bacteria K InterPro IPR007367 - - - - - - - - - - - - DUF433,MerR_1 k59_599818_1 1429046.RR21198_4077 2.5e-10 61.2 COG0745@1|root,COG0745@2|Bacteria,2GKJK@201174|Actinobacteria,4G6U4@85025|Nocardiaceae 201174|Actinobacteria T Transcriptional regulatory protein, C terminal tcsR4 - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_444976_1 81824.XP_001748915.1 1.39e-79 250.0 COG1960@1|root,KOG0140@2759|Eukaryota,38BNR@33154|Opisthokonta 33154|Opisthokonta I medium-chain-acyl-CoA dehydrogenase activity ACADM GO:0000062,GO:0000166,GO:0000271,GO:0001889,GO:0003674,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006082,GO:0006091,GO:0006109,GO:0006111,GO:0006112,GO:0006575,GO:0006577,GO:0006578,GO:0006629,GO:0006631,GO:0006635,GO:0006807,GO:0006950,GO:0007275,GO:0007507,GO:0007584,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009062,GO:0009250,GO:0009266,GO:0009409,GO:0009437,GO:0009605,GO:0009628,GO:0009719,GO:0009725,GO:0009791,GO:0009888,GO:0009889,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010675,GO:0010906,GO:0014070,GO:0014706,GO:0015980,GO:0016020,GO:0016042,GO:0016043,GO:0016051,GO:0016054,GO:0016491,GO:0016604,GO:0016607,GO:0016627,GO:0016853,GO:0017076,GO:0019216,GO:0019222,GO:0019254,GO:0019395,GO:0019752,GO:0022607,GO:0030154,GO:0030258,GO:0030424,GO:0030554,GO:0031090,GO:0031323,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033692,GO:0033993,GO:0034440,GO:0034637,GO:0034641,GO:0034645,GO:0035051,GO:0036094,GO:0042221,GO:0042398,GO:0042493,GO:0042594,GO:0042692,GO:0042802,GO:0042995,GO:0043005,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043436,GO:0043933,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0045329,GO:0046395,GO:0046688,GO:0048037,GO:0048513,GO:0048545,GO:0048731,GO:0048732,GO:0048738,GO:0048856,GO:0048869,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051146,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0051791,GO:0051793,GO:0055007,GO:0055114,GO:0060537,GO:0061008,GO:0061061,GO:0062012,GO:0065003,GO:0065007,GO:0070013,GO:0070991,GO:0071704,GO:0071840,GO:0072329,GO:0072359,GO:0080090,GO:0097159,GO:0097164,GO:0097367,GO:0097458,GO:0120025,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901567,GO:1901575,GO:1901576,GO:1901681 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_444976_2 925409.KI911562_gene44 2.94e-16 77.8 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,4NFUJ@976|Bacteroidetes,1IP28@117747|Sphingobacteriia 976|Bacteroidetes C malic enzyme maeB - 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_1592198_2 1123024.AUII01000006_gene4636 2.74e-56 197.0 COG3696@1|root,COG3696@2|Bacteria,2I53X@201174|Actinobacteria,4EE9U@85010|Pseudonocardiales 201174|Actinobacteria P AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_1494536_1 1380390.JIAT01000010_gene3964 1.27e-06 51.2 COG2267@1|root,COG2267@2|Bacteria,2I0NW@201174|Actinobacteria,4CQPG@84995|Rubrobacteria 84995|Rubrobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1 k59_1494536_2 314278.NB231_06041 4.07e-92 282.0 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales 135613|Chromatiales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_1440853_1 1123366.TH3_05004 8.36e-67 226.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2TS9R@28211|Alphaproteobacteria,2JPK5@204441|Rhodospirillales 204441|Rhodospirillales C Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA glcB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_339251_1 945713.IALB_2722 1.02e-17 75.1 2EGPU@1|root,33AFZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_339251_2 861299.J421_6044 8.41e-186 538.0 COG2192@1|root,COG2192@2|Bacteria,1ZUTI@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Carbamoyltransferase C-terminus - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_1017590_2 1158292.JPOE01000005_gene640 5.76e-31 112.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2VQ63@28216|Betaproteobacteria,1KJDX@119065|unclassified Burkholderiales 28216|Betaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_599838_1 234267.Acid_2112 7.27e-95 291.0 COG4993@1|root,COG4993@2|Bacteria,3Y73P@57723|Acidobacteria 57723|Acidobacteria G PQQ-like domain - - 1.1.2.8 ko:K00114 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - PQQ_2 k59_756337_1 635013.TherJR_0997 1.03e-27 115.0 COG0395@1|root,COG5001@1|root,COG5002@1|root,COG0395@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,26021@186807|Peptococcaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_8,PAS_9 k59_287054_1 717773.Thicy_0462 5.65e-43 142.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,46133@72273|Thiotrichales 72273|Thiotrichales J Sigma 54 modulation protein yhbH - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_287054_2 1232683.ADIMK_2787 6.63e-49 169.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,4642B@72275|Alteromonadaceae 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_1122449_1 985665.HPL003_20315 2.64e-11 65.1 COG0656@1|root,COG0656@2|Bacteria,1TSG5@1239|Firmicutes,4HAMT@91061|Bacilli,26QWW@186822|Paenibacillaceae 91061|Bacilli S aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_913836_1 1415780.JPOG01000001_gene2508 2.09e-37 144.0 2DBUU@1|root,2ZB7U@2|Bacteria,1R8WF@1224|Proteobacteria,1SMN0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1287125_1 644548.SCNU_14931 5.33e-58 187.0 28NTV@1|root,2ZBSB@2|Bacteria,2GS03@201174|Actinobacteria,4GB5B@85026|Gordoniaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1287125_2 247156.NFA_25810 3.44e-09 56.6 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4FW9P@85025|Nocardiaceae 201174|Actinobacteria Q Cytochrome P450 cyp123A3 GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616,GO:1902652 - - - - - - - - - - p450 k59_1287137_1 517433.PanABDRAFT_2416 2.05e-28 118.0 COG0554@1|root,COG0554@2|Bacteria,1MXIZ@1224|Proteobacteria,1RNTK@1236|Gammaproteobacteria,3VY9U@53335|Pantoea 1236|Gammaproteobacteria G Glycerol kinase glpK_1 - 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_869438_2 1234409.C683_1173 1.27e-50 173.0 COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4HA6Z@91061|Bacilli,4AZ5U@81852|Enterococcaceae 91061|Bacilli E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_1133324_1 292415.Tbd_1570 1.4e-05 52.4 COG0664@1|root,COG1295@1|root,COG0664@2|Bacteria,COG1295@2|Bacteria,1PWBZ@1224|Proteobacteria,2VY5Z@28216|Betaproteobacteria 28216|Betaproteobacteria T Virulence factor BrkB - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB,cNMP_binding k59_1659984_1 477184.KYC_25977 4.41e-96 302.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VJD5@28216|Betaproteobacteria,3T6F9@506|Alcaligenaceae 28216|Betaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA2 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_869442_1 105559.Nwat_2194 1.48e-20 89.7 2952G@1|root,2ZSF9@2|Bacteria,1NFKJ@1224|Proteobacteria,1SDRS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_96333_1 215803.DB30_4316 8.81e-28 112.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,42M3Y@68525|delta/epsilon subdivisions,2WJH5@28221|Deltaproteobacteria,2YTZQ@29|Myxococcales 28221|Deltaproteobacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_96333_2 96561.Dole_0475 4.13e-27 106.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2WMS3@28221|Deltaproteobacteria,2MI7H@213118|Desulfobacterales 28221|Deltaproteobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_1599876_1 903818.KI912268_gene1552 3.8e-13 74.7 COG1463@1|root,COG1463@2|Bacteria 2|Bacteria Q ABC-type transport system involved in resistance to organic solvents, periplasmic component - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_714874_1 83406.HDN1F_23180 6.28e-48 166.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1J95I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_185450_1 926569.ANT_02730 8.9e-10 58.2 COG0695@1|root,COG0695@2|Bacteria,2G706@200795|Chloroflexi 200795|Chloroflexi O Glutaredoxin - - - - - - - - - - - - Glutaredoxin k59_185450_2 1123366.TH3_07025 5.15e-21 89.7 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2TR5J@28211|Alphaproteobacteria,2JQTM@204441|Rhodospirillales 204441|Rhodospirillales L exodeoxyribonuclease III xth - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_1599883_2 1249480.B649_03920 1.07e-12 67.8 COG0656@1|root,COG0656@2|Bacteria,1PGB3@1224|Proteobacteria,42PPT@68525|delta/epsilon subdivisions,2YN3U@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_1390524_1 156889.Mmc1_2551 1.23e-38 140.0 COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,2U24Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Integrase - - - - - - - - - - - - HTH_32,rve,rve_3 k59_1241652_1 247633.GP2143_14781 1.17e-62 213.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1J4FT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1133340_2 1121121.KB894296_gene756 6.65e-65 213.0 COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,4HAD8@91061|Bacilli,26T5F@186822|Paenibacillaceae 91061|Bacilli M cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - iYO844.BSU15230 FAD_binding_4,MurB_C k59_1241654_1 1229909.NSED_09250 3.8e-46 154.0 arCOG08776@1|root,arCOG08776@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_96356_2 246196.MSMEI_0291 4.22e-44 146.0 2EUA2@1|root,33MSG@2|Bacteria,2IMWS@201174|Actinobacteria,23AAI@1762|Mycobacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_829292_1 1589733.A0A0C5AAX2_9CAUD 3.15e-45 168.0 4QEE7@10239|Viruses,4QPT7@28883|Caudovirales,4QI2X@10662|Myoviridae 10662|Myoviridae S Pfam:DUF4815 - - - - - - - - - - - - - k59_349843_1 634956.Geoth_0303 2.56e-22 94.7 COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,4HA3Y@91061|Bacilli,1WHF3@129337|Geobacillus 91061|Bacilli M Male sterility protein - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_555731_1 2340.JV46_25130 1.94e-53 179.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1J5VQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S esterase of the alpha-beta hydrolase superfamily rssA GO:0003674,GO:0003824,GO:0016787 - ko:K07001 - - - - ko00000 - - - Patatin k59_96363_1 1379698.RBG1_1C00001G0776 2.58e-29 118.0 COG2864@1|root,COG2864@2|Bacteria,2NNNM@2323|unclassified Bacteria 2|Bacteria C Cytochrome b subunit of formate dehydrogenase-like protein - - - - - - - - - - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB k59_869487_1 1124982.MSI_21690 4.45e-08 60.1 COG3864@1|root,COG3864@2|Bacteria,2J6M4@203691|Spirochaetes 203691|Spirochaetes S VWA-like domain (DUF2201) - - - - - - - - - - - - DUF2201,DUF2201_N k59_1025789_1 1163617.SCD_n02698 7.54e-53 182.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,2VMTN@28216|Betaproteobacteria 28216|Betaproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_1178902_1 96561.Dole_0728 2.98e-26 107.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria,2MHM9@213118|Desulfobacterales 28221|Deltaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_1178902_2 1307759.JOMJ01000003_gene429 1.14e-35 127.0 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,42SRC@68525|delta/epsilon subdivisions,2WQQ4@28221|Deltaproteobacteria,2MBG4@213115|Desulfovibrionales 28221|Deltaproteobacteria J binds to the 23S rRNA rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_1178902_3 1382356.JQMP01000003_gene2278 3.83e-12 61.6 COG1841@1|root,COG1841@2|Bacteria,2G7E7@200795|Chloroflexi,27YRK@189775|Thermomicrobia 189775|Thermomicrobia J Ribosomal protein L30p/L7e rpmD - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_16572_1 933262.AXAM01000016_gene149 8.35e-101 314.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales 28221|Deltaproteobacteria M TIGRFAM penicillin-binding protein, 1A family mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_513361_1 637389.Acaty_c0586 9.6e-21 93.6 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,2NBUP@225057|Acidithiobacillales 225057|Acidithiobacillales O Tetratricopeptide repeat - - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_1241693_1 644282.Deba_2836 6.57e-41 155.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_714932_1 740709.A10D4_13081 1.5e-09 62.4 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,2QFEQ@267893|Idiomarinaceae 1236|Gammaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_714932_2 1229520.ADIAL_0138 6.93e-09 56.2 COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,4HAMU@91061|Bacilli,27FWH@186828|Carnobacteriaceae 91061|Bacilli E Pyridoxal-phosphate dependent enzyme cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1390571_1 436308.Nmar_1727 5.35e-142 417.0 COG1782@1|root,arCOG00543@2157|Archaea,41T05@651137|Thaumarchaeota 651137|Thaumarchaeota S RNA-metabolising metallo-beta-lactamase - - - ko:K07041 - - - - ko00000 - - - Beta-Casp,KH_7,Lactamase_B_6,RMMBL k59_96402_1 1163617.SCD_n02389 3.27e-34 137.0 COG3063@1|root,COG3063@2|Bacteria 2|Bacteria NU photosynthesis - - 2.1.1.80 ko:K00575,ko:K02453,ko:K02656,ko:K20543 ko02020,ko02030,ko03070,ko05111,map02020,map02030,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko01000,ko02000,ko02035,ko02044 1.B.55.3,3.A.15 - - ANAPC5,Secretin,TPR_16,TPR_19,TPR_8 k59_1449119_1 1230476.C207_00264 6.71e-100 298.0 COG0111@1|root,COG0111@2|Bacteria,1MW0R@1224|Proteobacteria,2TWC9@28211|Alphaproteobacteria,3JVP3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_555780_1 448385.sce5468 3.56e-126 380.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WKYA@28221|Deltaproteobacteria,2YU1C@29|Myxococcales 28221|Deltaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455,ko:K11745,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.1,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N k59_1081398_1 449447.MAE_61530 7.64e-48 169.0 COG1861@1|root,COG1861@2|Bacteria,1G3T7@1117|Cyanobacteria 1117|Cyanobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_455577_1 1009370.ALO_07283 4.92e-28 110.0 COG1234@1|root,COG1234@2|Bacteria 2|Bacteria L tRNA 3'-trailer cleavage MA20_22080 - - - - - - - - - - - Lactamase_B_2 k59_455577_2 1038859.AXAU01000002_gene757 5.29e-17 82.4 COG0112@1|root,COG0112@2|Bacteria,1R3T8@1224|Proteobacteria,2U2N3@28211|Alphaproteobacteria,3JT5C@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism - - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_297761_1 296591.Bpro_5532 1.39e-16 80.5 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2VI1H@28216|Betaproteobacteria,4ABHU@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM transposase, IS4 family protein - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_1133410_1 1033738.CAEP01000007_gene2985 1.57e-07 56.6 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,4HBQ6@91061|Bacilli,26CUN@186818|Planococcaceae 91061|Bacilli J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_1081405_1 765914.ThisiDRAFT_2315 8.16e-101 325.0 COG0187@1|root,COG1372@1|root,COG0187@2|Bacteria,COG1372@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1178938_1 436308.Nmar_1064 1.96e-117 343.0 COG0444@1|root,arCOG00181@2157|Archaea,41S9V@651137|Thaumarchaeota 651137|Thaumarchaeota E Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_96427_1 1125863.JAFN01000001_gene2900 4.24e-23 101.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_607571_1 472759.Nhal_0828 3.05e-55 187.0 COG0515@1|root,COG0515@2|Bacteria,1QXK0@1224|Proteobacteria,1T3DE@1236|Gammaproteobacteria 1236|Gammaproteobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K11912 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - Pkinase,TIR_2 k59_242864_1 439235.Dalk_3613 1.76e-45 159.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2MMPC@213118|Desulfobacterales 28221|Deltaproteobacteria NU PFAM Type II IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_829405_1 1196324.A374_04054 2.1e-16 76.6 COG0425@1|root,COG0607@1|root,COG0425@2|Bacteria,COG0607@2|Bacteria,1V1GU@1239|Firmicutes,4HFR8@91061|Bacilli 91061|Bacilli OP Belongs to the sulfur carrier protein TusA family yrkF - - - - - - - - - - - Rhodanese,TusA k59_1081425_1 316055.RPE_1726 3.42e-43 149.0 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2TUND@28211|Alphaproteobacteria,3JRSJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T helix_turn_helix, Lux Regulon fixJ - - ko:K14987 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_185537_1 666685.R2APBS1_2588 4.32e-62 208.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1X3CI@135614|Xanthomonadales 135614|Xanthomonadales G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_1599976_2 279383.Q5DN23_9CAUD 1.94e-36 145.0 4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - - - - - - - - - - - - - k59_1335159_1 1229780.BN381_430045 8.59e-54 187.0 COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria 201174|Actinobacteria IQ synthetase fadD19_2 - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_672294_1 395961.Cyan7425_3964 1.84e-09 63.5 COG3670@1|root,COG3670@2|Bacteria,1G0AF@1117|Cyanobacteria,3KFZ8@43988|Cyanothece 1117|Cyanobacteria C PFAM Carotenoid oxygenase - - - - - - - - - - - - RPE65 k59_607605_2 1287276.X752_03930 9.59e-06 50.1 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,2U3PW@28211|Alphaproteobacteria,43N36@69277|Phyllobacteriaceae 28211|Alphaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1449176_1 519989.ECTPHS_07067 1.24e-17 82.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, chain G - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1449176_2 1500893.JQNB01000001_gene3172 3.91e-56 187.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1X2ZD@135614|Xanthomonadales 135614|Xanthomonadales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_555850_1 383372.Rcas_4158 1.54e-16 84.0 COG2304@1|root,COG2304@2|Bacteria 2|Bacteria IU oxidoreductase activity - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_400632_1 247633.GP2143_08589 4.07e-70 221.0 COG3219@1|root,COG3219@2|Bacteria,1R8C9@1224|Proteobacteria,1S23S@1236|Gammaproteobacteria,1J6PK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09929 - - - - ko00000 - - - DUF2063 k59_1178993_1 706587.Desti_4883 7.02e-39 144.0 COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,42YIF@68525|delta/epsilon subdivisions,2WU4S@28221|Deltaproteobacteria,2MQET@213462|Syntrophobacterales 28221|Deltaproteobacteria EGP PFAM Major Facilitator Superfamily - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_185568_1 391615.ABSJ01000045_gene2018 1.19e-66 212.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,1J5QI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_16959_1 1122604.JONR01000001_gene1704 6.37e-25 107.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1RMHR@1236|Gammaproteobacteria,1X5VF@135614|Xanthomonadales 135614|Xanthomonadales Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_466626_1 1207076.ALAT01000183_gene3046 4.55e-23 102.0 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria,1Z1U9@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N k59_1189117_1 436308.Nmar_0189 4.88e-24 105.0 COG0642@1|root,arCOG02358@2157|Archaea 2157|Archaea T Histidine kinase - - 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_1608069_2 1380600.AUYN01000006_gene551 1.43e-13 72.4 COG1040@1|root,COG1040@2|Bacteria,4NNI1@976|Bacteroidetes,1I22C@117743|Flavobacteriia 976|Bacteroidetes S amidophosphoribosyl-transferase comF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - Pribosyltran k59_1400773_1 1123257.AUFV01000023_gene40 2.77e-53 191.0 2DBGS@1|root,2Z95N@2|Bacteria,1QSNI@1224|Proteobacteria,1RR96@1236|Gammaproteobacteria,1X9M2@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_1252373_1 234267.Acid_0017 2.19e-32 124.0 COG1475@1|root,COG1475@2|Bacteria,3Y40Y@57723|Acidobacteria 57723|Acidobacteria K Belongs to the ParB family - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_1145864_1 1265313.HRUBRA_00383 4.69e-34 133.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1J530@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria FP Belongs to the GppA Ppx family gppA GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006082,GO:0006139,GO:0006725,GO:0006793,GO:0006797,GO:0006798,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008894,GO:0009056,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034641,GO:0042594,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:1901360,GO:1901575 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c42590,iECED1_1282.ECED1_4463,iECIAI39_1322.ECIAI39_2643 HD,Ppx-GppA k59_1459351_1 335541.Swol_0569 8.28e-78 244.0 COG0142@1|root,COG0142@2|Bacteria,1TPQY@1239|Firmicutes,248DE@186801|Clostridia,42JTQ@68298|Syntrophomonadaceae 186801|Clostridia H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_309185_1 395493.BegalDRAFT_0459 1e-62 202.0 COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,1RPS3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - - - - - - - - - - Lactamase_B_2 k59_1551769_1 1304875.JAFZ01000001_gene1959 1.41e-08 58.9 COG1484@1|root,COG1484@2|Bacteria,3TBI2@508458|Synergistetes 508458|Synergistetes L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21,IstB_IS21_ATP k59_982953_2 1123368.AUIS01000006_gene628 4.45e-13 67.8 2ADFF@1|root,3135I@2|Bacteria,1QCUP@1224|Proteobacteria,1T8MW@1236|Gammaproteobacteria,2ND4T@225057|Acidithiobacillales 225057|Acidithiobacillales - - - - - - - - - - - - - - - k59_982956_1 1047013.AQSP01000104_gene1415 4.49e-24 107.0 COG1538@1|root,COG1538@2|Bacteria,2NP5D@2323|unclassified Bacteria 2|Bacteria MU Outer membrane efflux protein tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_412271_1 765914.ThisiDRAFT_2558 1.94e-19 87.4 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1WVZJ@135613|Chromatiales 135613|Chromatiales U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_412271_2 1216007.AOPM01000057_gene1850 9.64e-28 109.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,2PZWZ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Belongs to the ompA family pal GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032153,GO:0044425,GO:0044462,GO:0044464,GO:0051301,GO:0071944,GO:0098552 - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_1551798_1 330214.NIDE1631 4.96e-29 112.0 COG0752@1|root,COG0752@2|Bacteria,3J0F5@40117|Nitrospirae 40117|Nitrospirae J Glycyl-tRNA synthetase alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_1551798_2 1158318.ATXC01000001_gene1208 1.51e-12 69.7 COG0751@1|root,COG0751@2|Bacteria,2G3K3@200783|Aquificae 200783|Aquificae J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_1459404_2 1210884.HG799465_gene11478 9.36e-30 121.0 COG3591@1|root,COG3591@2|Bacteria,2J1Y0@203682|Planctomycetes 203682|Planctomycetes E Peptidase S46 - - - - - - - - - - - - Peptidase_S46 k59_982981_1 118163.Ple7327_2973 7.8e-21 92.4 COG0304@1|root,COG0304@2|Bacteria,1G1J5@1117|Cyanobacteria,3VIR6@52604|Pleurocapsales 1117|Cyanobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_982981_2 861299.J421_4184 3.11e-35 125.0 COG2867@1|root,COG2867@2|Bacteria,1ZTVW@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc k59_1551806_1 571166.KI421509_gene965 2.45e-111 330.0 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria 28211|Alphaproteobacteria L NADP-dependent oxidoreductase MA20_40260 - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N k59_309231_1 138119.DSY1697 3.6e-10 57.8 COG1983@1|root,COG1983@2|Bacteria,1VKBQ@1239|Firmicutes,24QU9@186801|Clostridia,262YN@186807|Peptococcaceae 186801|Clostridia KT Stress-responsive transcriptional regulator - - - ko:K03973 - - - - ko00000,ko02048,ko03000 - - - PspC k59_1036489_1 382464.ABSI01000010_gene3667 5.77e-16 74.3 COG1845@1|root,COG1845@2|Bacteria,46SRD@74201|Verrucomicrobia,2IU4E@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Cytochrome c oxidase subunit III - - - - - - - - - - - - COX3 k59_1036489_2 756272.Plabr_2265 7.25e-36 137.0 COG0843@1|root,COG0843@2|Bacteria,2IXCQ@203682|Planctomycetes 203682|Planctomycetes C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_1145933_1 768671.ThimaDRAFT_0301 2.46e-44 164.0 COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,1S0TR@1236|Gammaproteobacteria,1WZ58@135613|Chromatiales 135613|Chromatiales P Cytochrome c554 and c-prime - - - - - - - - - - - - - k59_1189212_1 330214.NIDE0836 3.1e-93 294.0 COG1048@1|root,COG1048@2|Bacteria,3J0E6@40117|Nitrospirae 40117|Nitrospirae C Aconitase C-terminal domain - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_619363_1 765911.Thivi_1669 6.68e-83 255.0 COG1897@1|root,COG1897@2|Bacteria,1MV64@1224|Proteobacteria,1RM7T@1236|Gammaproteobacteria,1WWUS@135613|Chromatiales 135613|Chromatiales E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metAS - 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - HTS k59_466730_1 1265505.ATUG01000001_gene4066 5.63e-20 94.7 COG0421@1|root,COG0421@2|Bacteria,1R09C@1224|Proteobacteria,42YKN@68525|delta/epsilon subdivisions,2X800@28221|Deltaproteobacteria,2MJY9@213118|Desulfobacterales 28221|Deltaproteobacteria E Tetratricopeptide repeat - - - - - - - - - - - - - k59_1459433_1 571166.KI421509_gene4409 3.12e-125 374.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_153266_1 1122185.N792_06590 1.06e-18 83.6 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria,1X302@135614|Xanthomonadales 135614|Xanthomonadales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_153267_1 1242864.D187_008933 2.61e-46 167.0 COG3391@1|root,COG3391@2|Bacteria,1R7E0@1224|Proteobacteria,42Z2U@68525|delta/epsilon subdivisions,2WTYD@28221|Deltaproteobacteria,2YX64@29|Myxococcales 28221|Deltaproteobacteria S Cytochrome D1 heme domain - - - - - - - - - - - - Cytochrom_D1 k59_619381_2 259536.Psyc_0056 1.7e-09 60.8 COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria,3NN70@468|Moraxellaceae 1236|Gammaproteobacteria L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yqgF GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_253572_1 1026882.MAMP_01479 2.3e-97 302.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,45ZQH@72273|Thiotrichales 72273|Thiotrichales E peptidase - - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_881338_1 1125863.JAFN01000001_gene685 9.76e-28 112.0 COG0463@1|root,COG0463@2|Bacteria,1MW2G@1224|Proteobacteria,43BKJ@68525|delta/epsilon subdivisions,2WIZJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_468266_1 1122134.KB893651_gene2268 1.27e-111 322.0 COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,1RMCD@1236|Gammaproteobacteria,1XI80@135619|Oceanospirillales 135619|Oceanospirillales F Belongs to the dCTP deaminase family dcd - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase k59_1553422_2 1111479.AXAR01000016_gene3112 6.03e-19 80.5 COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,4HKE9@91061|Bacilli,278I7@186823|Alicyclobacillaceae 91061|Bacilli J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_1347007_1 1205908.AKXW01000086_gene2125 6.2e-05 47.0 2DM7I@1|root,32UGD@2|Bacteria,1N3NM@1224|Proteobacteria,1SAIU@1236|Gammaproteobacteria,1XV0E@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - k59_1553441_1 234267.Acid_7572 9.24e-44 162.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 k59_1190818_1 436308.Nmar_0255 2.45e-51 162.0 COG1581@1|root,arCOG01753@2157|Archaea,41SQ4@651137|Thaumarchaeota 651137|Thaumarchaeota K Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes - - - ko:K03622 - - - - ko00000 - - - Alba k59_1190818_2 436308.Nmar_0256 3.99e-70 218.0 COG2513@1|root,arCOG00581@2157|Archaea,41SEN@651137|Thaumarchaeota 651137|Thaumarchaeota G Phosphoenolpyruvate phosphomutase - - - - - - - - - - - - PEP_mutase k59_937925_1 1268237.G114_09012 4.37e-100 317.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1Y3WK@135624|Aeromonadales 135624|Aeromonadales J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_1460999_1 323259.Mhun_0542 1.05e-06 53.5 COG0589@1|root,arCOG02053@2157|Archaea 2157|Archaea T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp k59_1037792_1 314278.NB231_01219 1.45e-118 346.0 COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,1RMS7@1236|Gammaproteobacteria,1WWCG@135613|Chromatiales 135613|Chromatiales C PFAM Phosphoribulokinase uridine kinase - - 2.7.1.19 ko:K00855 ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200 M00165,M00166 R01523 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PRK k59_621087_1 1323663.AROI01000020_gene649 1.47e-54 174.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,1S5BM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S phospholipid-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_1147779_1 2340.JV46_18170 3.3e-13 73.9 COG1416@1|root,COG1416@2|Bacteria,1N96Y@1224|Proteobacteria,1SZYQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria K AntiSigma factor - - - - - - - - - - - - - k59_726902_1 1279019.ARQK01000034_gene1117 1.43e-59 194.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,1WXPV@135613|Chromatiales 135613|Chromatiales H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group cyoE - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_1037795_1 330214.NIDE4112 2.09e-114 342.0 COG3635@1|root,COG3635@2|Bacteria,3J0YA@40117|Nitrospirae 40117|Nitrospirae G Metalloenzyme superfamily - - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase k59_413960_1 1283300.ATXB01000001_gene1402 2.4e-76 244.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1XEVV@135618|Methylococcales 135618|Methylococcales EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1402419_1 1121405.dsmv_1569 1.17e-35 134.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2MHTP@213118|Desulfobacterales 28221|Deltaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1276 CTP_synth_N,GATase k59_984757_1 667014.Thein_0070 1.23e-66 211.0 COG0152@1|root,COG0152@2|Bacteria,2GH07@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria F SAICAR synthetase purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_984757_2 243233.MCA1710 7.57e-05 45.8 2917K@1|root,2ZNUR@2|Bacteria,1QJM0@1224|Proteobacteria,1THMN@1236|Gammaproteobacteria,1XEVJ@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - k59_621115_1 1121937.AUHJ01000001_gene372 9.67e-23 99.4 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_621115_2 1205680.CAKO01000002_gene2127 1.11e-12 67.8 COG2141@1|root,COG2141@2|Bacteria,1MUTJ@1224|Proteobacteria,2TTZI@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_1461039_1 583355.Caka_0865 4.51e-100 307.0 COG1032@1|root,COG1032@2|Bacteria,46V7P@74201|Verrucomicrobia,3K74V@414999|Opitutae 414999|Opitutae C Domain of unknown function (DUF4070) - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_1147824_1 314285.KT71_13854 3.99e-70 232.0 COG0433@1|root,COG0433@2|Bacteria,1QUPX@1224|Proteobacteria,1T20D@1236|Gammaproteobacteria,1JC04@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S TraM recognition site of TraD and TraG - - - - - - - - - - - - T4SS-DNA_transf,TraG-D_C,TrwB_AAD_bind k59_1037831_1 1182590.BN5_01863 3.98e-40 149.0 COG2172@1|root,COG2208@1|root,COG3437@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,COG3437@2|Bacteria,1N4K5@1224|Proteobacteria,1RNYP@1236|Gammaproteobacteria,1YCSI@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Sigma factor PP2C-like phosphatases rsbU - - ko:K20977 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko02022 - - - HATPase_c_2,Response_reg,SpoIIE k59_468357_1 1131269.AQVV01000082_gene26 2.83e-06 57.0 COG0457@1|root,COG4262@1|root,COG0457@2|Bacteria,COG4262@2|Bacteria 2|Bacteria H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - MFS_1,Spermine_synth k59_21942_1 756272.Plabr_2749 6.02e-16 80.9 COG1520@1|root,COG1520@2|Bacteria,2IXSV@203682|Planctomycetes 203682|Planctomycetes S PQQ-like domain - - - - - - - - - - - - PQQ_2 k59_1609460_1 436308.Nmar_1030 1.09e-70 216.0 COG1611@1|root,arCOG02431@2157|Archaea,41SMW@651137|Thaumarchaeota 651137|Thaumarchaeota S Rossmann fold nucleotide-binding protein - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_1609460_2 192952.MM_3077 2.14e-14 72.4 COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,2N9XS@224756|Methanomicrobia 224756|Methanomicrobia T Universal stress protein family - - - - - - - - - - - - Usp ## 23772 queries scanned ## Total time (seconds): 261.2428984642029 ## Rate: 91.00 q/s